Mutagenic activity of phosmet, the active component of the organophosphorus insecticide Decemtione EK 20 in Salmonella and Saccharomyces assays.
Phosmet, the active component of the organophosphorus insecticide Decemtione EK 20, was shown to be mutagenic in the standard Ames Salmonella/mammalian microsome assay in the absence and presence of metabolic activation. It appears to be a direct mutagen inducing base substitution mutations (TA100) as well as a weak frameshift mutagen (TA97). This compound was genotoxic in the Saccharomyces cerevisiae D7 strain. It significantly increased reverse mutation, mitotic crossing-over and slightly, but not significantly, increased gene conversion at the highest concentration used.
Vlcková
V
V
Department of Genetics, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
Miadoková
E
E
Podstavková
S
S
Vlcek
D
D
D000818:Animals; D001711:Biotransformation; D016368:Frameshift Mutation; D007306:Insecticides / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity*; D010706:Phosmet / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
D007306:Insecticides; D009153:Mutagens; D010706:Phosmet