title: Clonal chromosome abnormalities in human breast carcinomas. I. Twenty-eight cases with primary disease.
abstract: Cytogenetic analysis was performed on a selected series of short-term cultures of primary breast carcinomas from 28 patients. All patients had histopathologically confirmed malignancies, with the majority (25/28 cases) demonstrating infiltrating ductal carcinoma. All 28 cases evidenced clonal chromosome abnormalities, with 10/28 displaying only numeric aberrations, whereas 18/28 displayed clonal structural alterations. In near-diploid tumors the most common numeric changes were -17 and -19. However, trisomy 7 was the only numeric change in two near-diploid tumors. Structural chromosome alterations were primarily isochromosomes, apparent terminal deletions, and unbalanced non-reciprocal translocations. Chromosomes I (10/18-56%) and 6 (8/18-44%) were most frequently altered in this series. Breakpoints of clonal structural abnormalities were shown to cluster to several chromosome segments, including 1p22-q11, 3p11, 6p11-13, 7p11-q11, 8p11-q11, and 19q13. Analysis of the gain or loss of specific chromosome segments revealed that the most consistent tendency was over-representation of 1q, 3q, and 6p.
authors.affiliation: Arizona Cancer Center, University of Arizona, Tucson.
authors.forename: F
authors.initials: F
authors.lastname: Thompson
authors.forename: J
authors.initials: J
authors.lastname: Emerson
authors.forename: W
authors.initials: W
authors.lastname: Dalton
authors.forename: J M
authors.initials: JM
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: McGee
authors.forename: H
authors.initials: H
authors.lastname: Villar
authors.forename: S
authors.initials: S
authors.lastname: Knox
authors.forename: K
authors.initials: K
authors.lastname: Massey
authors.forename: R
authors.initials: R
authors.lastname: Weinstein
authors.forename: A
authors.initials: A
authors.lastname: Bhattacharyya
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics*; D018275:Carcinoma, Lobular / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged