Heparin-binding fibroblast growth factors and prostate cancer.
Studies of model rat prostate tissue and derived cells indicate the insulin-like (IGF), epidermal growth factor (EGF), transforming growth factor beta (TGF-beta) and heparin-binding fibroblast growth factor (HBGF) families and their receptors may play important roles in regulation of normal prostate cell growth. Tumor cells at different levels in the progression from slow-growing, hormone-dependence to fast-growing, hormone-independence exhibit distinct alterations in expression of specific growth factors and their receptor phenotype. Distinct IGF-I and HBGF mRNAs are constitutively expressed in the mesenchymal cells of slow-tumors, but alteration in HBGF receptor phenotype occurs in the epithelial cells. Fast-tumors exhibit even higher constitutive expression of multiple HBGFs. Splice variants in cDNA for the HBGF receptor in fast-tumors suggest constitutive expression of an intracellular receptor, that together with intracellular HBGFs, may constitute an intracellular autocrine system that is independent of exogenous hormones and growth factors.
McKeehan
W L
WL
W. Alton Jones Cell Science Center, Inc., Lake Placid, N.Y. 12946.
Hou
J
J
Adams
P
P
Wang
F
F
Yan
G C
GC
Kan
M
M
D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003238:Connective Tissue / Q000378:metabolism / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D016220:Fibroblast Growth Factor 1 / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006133:Growth Substances / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology; D008297:Male; D008969:Molecular Sequence Data; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D012326:RNA Splicing; D051381:Rats; D011956:Receptors, Cell Surface / Q000096:biosynthesis / Q000187:drug effects; D017468:Receptors, Fibroblast Growth Factor / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D006133:Growth Substances; D006728:Hormones; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D016220:Fibroblast Growth Factor 1