Transcriptional regulation. Converting an activator into a repressor.
Dorsoventral patterning in Drosophila requires the Dorsal morphogen to act as both an activator and a repressor of transcription: an HMG1-like protein may serve to switch Dorsal from one to the other.
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Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605.
D000818:Animals; D004247:DNA / Q000378:metabolism; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D006609:High Mobility Group Proteins / Q000502:physiology; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D012097:Repressor Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*; D014157:Transcription Factors; D014158:Transcription, Genetic / Q000502:physiology*
D029721:Drosophila Proteins; D006609:High Mobility Group Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C062236:dl protein, Drosophila; D004247:DNA