[Comparison of 7 anti-hepatitis C virus enzyme immunoassays of the 2nd generation in blood donation services].
Seven enzyme-linked immunosorbent assays for the detection of antibodies to hepatitis C virus were compared: three assays with synthetic peptides in the coating showed overproportional higher rates of initial reactive and also the highest rate of so-called false-positive results in comparison with the RIBA assay. One assay with synthetic peptides had also the most false-negative results in comparison with RIBA-reactive results. The best results are found in assays with recombinant proteins, in which proteins derived from the NS-4 region are present.
Gabriel
C
C
Blutspendedienst vom Roten Kreuz für Oberösterreich, Blutzentrale Linz, Osterreich.
Blauhut
B
B
D000956:Antigens, Viral / Q000097:blood*; D006526:Hepatitis C / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D018936:Hepatitis C Antigens; D006801:Humans; D007124:Immunoenzyme Techniques; D008403:Mass Screening; D011237:Predictive Value of Tests
D000956:Antigens, Viral; D018936:Hepatitis C Antigens