title: AMPA and NMDA binding sites in the hypothalamic lateral tuberal nucleus: implications for Huntington's disease.
abstract: The excitatory amino acid (EAA) hypothesis of neuronal loss in Huntington's disease predicts that structures that show neuronal loss and gliosis will contain receptor-bearing neurons. In accordance with this hypothesis, the hypothalamic lateral tuberal nucleus, severely affected in Huntington's disease, showed a high density of NMDA and AMPA binding sites in four normal subjects.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Kremer
authors.forename: S J
authors.initials: SJ
authors.lastname: Tallaksen-Greene
authors.forename: R L
authors.initials: RL
authors.lastname: Albin
mesh_terms: D000368:Aged; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism*; D007026:Hypothalamic Area, Lateral / Q000378:metabolism*; D007051:Ibotenic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D007608:Kainic Acid / Q000378:metabolism; D008875:Middle Aged; D016202:N-Methylaspartate / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
chemical_list: D005971:Glutamates; D016194:Receptors, N-Methyl-D-Aspartate; D007051:Ibotenic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007608:Kainic Acid