title: Combined application of MH and TEM for conditioning treatment simultaneously triggers two protective functions against induction of chromatid aberrations in Vicia faba root tip meristem cells.
abstract: Conditioning pre-exposure of Vicia faba root tip meristem cells to triethylenemelamine (TEM) does not trigger an adaptive response to maleic hydrazide (MH) and vice versa. Since TEM conditioning treatment can induce protective effects (as evident from the yield of metaphases with chromatid aberrations) against TEM challenging treatment and MH conditioning can trigger an adaptive response to MH challenging treatment, two different protective functions are apparently triggered in dependence on the agent used for conditioning pre-exposure. When a mixture of TEM and MH is being used for conditioning treatment, adaptive responses to both TEM and MH can simultaneously be induced and significantly reduce the yield of metaphases with chromatid aberrations observed after challenge treatment with TEM or MH.
authors.affiliation: Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Rieger
authors.forename: A
authors.initials: A
authors.lastname: Michaelis
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D002869:Chromosome Aberrations; D007887:Fabaceae / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D008300:Maleic Hydrazide / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D010946:Plants, Medicinal; D014265:Triethylenemelamine / Q000633:toxicity*
chemical_list: D009153:Mutagens; D014265:Triethylenemelamine; D008300:Maleic Hydrazide