Receptor sites for open channel blockers of Shaker voltage-gated potassium channels--molecular approaches.
The Shaker locus encodes a family of voltage-gated potassium (K) channels expressed in the central and peripheral nervous system as well as in muscle. Members of the Shaker K-family have variant amino- and carboxy-terminal sequences, which assemble into homo- and hetero-multimeric K-channels. The channels have distinct kinetics of activation and inactivation. Electrophysiological characterization of wild type and mutant K-channels allows to correlate particular domains and critical amino acid residues with receptor sites of open channel blockers such as tetraethylammonium, charybdotoxin and dendrotoxin.
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Zentrum für Molekulare Neurobiologie, Universität Hamburg.
D000595:Amino Acid Sequence; D000818:Animals; D018999:Charybdotoxin; D004330:Drosophila / Q000235:genetics; D004546:Elapid Venoms / Q000494:pharmacology; D015640:Ion Channel Gating / Q000187:drug effects* / Q000235:genetics; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009498:Neurotoxins / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects* / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000187:drug effects; D012604:Scorpion Venoms / Q000494:pharmacology; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D014981:Xenopus
D004546:Elapid Venoms; D009498:Neurotoxins; D015221:Potassium Channels; D011993:Recombinant Fusion Proteins; D012604:Scorpion Venoms; D013757:Tetraethylammonium Compounds; D018999:Charybdotoxin; D019789:Tetraethylammonium; C020273:dendrotoxin