title: Human macrophage colony-stimulating factor levels in cerebrospinal fluid.
abstract: Macrophage colony-stimulating factor (M-CSF) levels in the cerebrospinal fluid of 14 patients with meningitis and of 14 patients suffering from a disease other than meningitis were measured using an enzyme-linked immunosorbent assay. All four bacterial meningitis patients had M-CSF levels in the cerebrospinal fluid which exceeded 1540 U/ml, and the mean value was 3333 +/- 1481 U/ml. The mean M-CSF level in the cerebrospinal fluid of the ten aseptic meningitis patients was 393 +/- 175 U/ml, which was higher than that of patients who suffered from a disease other than meningitis (179 +/- 90 U/ml) (P < 0.01). There was no clear correlation between the M-CSF levels and the numbers of white blood cells, granulocytes, or monocytes in the cerebrospinal fluid. These elevated M-CSF levels were thought to be of a local origin, since most patients with high M-CSF levels in the cerebrospinal fluid had relatively low M-CSF levels in the serum.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimoda
authors.forename: S
authors.initials: S
authors.lastname: Okamura
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: N
authors.initials: N
authors.lastname: Harada
authors.forename: A
authors.initials: A
authors.lastname: Kubota
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: H
authors.initials: H
authors.lastname: Akeda
authors.forename: K
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D016179:Granulocyte Colony-Stimulating Factor / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood / Q000134:cerebrospinal fluid*; D008582:Meningitis, Aseptic / Q000097:blood / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid*; D008583:Meningitis, Haemophilus / Q000097:blood / Q000134:cerebrospinal fluid; D008586:Meningitis, Pneumococcal / Q000097:blood / Q000134:cerebrospinal fluid; D013997:Time Factors
chemical_list: D015415:Biomarkers; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor