Localization of the human HER4/erbB-4 gene to chromosome 2.
The HER4/erbB-4 gene has been isolated as the fourth member of the human EGFR subfamily of tyrosine kinases and has been reported to encode a receptor for NDF/heregulin. In the present study we determined the chromosomal location of the HER4/erbB-4 gene within the human genome. Using human cDNA probes in fluorescence in situ hybridization (FISH), we mapped the HER4/erbB-4 gene to human chromosome 2q33.3-34. This finding established that also the HER4/erbB-4 gene is located in close vicinity of homeobox and collagen gene loci, as is the case for the related EGFR, erbB-2/neu and erbB-3. Aberrations of this chromosomal region associated with T cell leukemias and lymphomas as well as alveolar rhabdomyosarcomas raise the possibility that HER4/erbB-4 might be activated in these tumour types.
Zimonjic
D B
DB
Laboratory of Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Alimandi
M
M
Miki
T
T
Popescu
N C
NC
Kraus
M H
MH
D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D018076:DNA, Complementary; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D066247:Receptor, ErbB-4
D018076:DNA, Complementary; C587689:ERBB4 protein, human; D066246:ErbB Receptors; D066247:Receptor, ErbB-4