title: The use of bioelectrical impedance analysis to predict total body water in patients with cancer cachexia.
abstract: The applicability of bioelectrical impedance analysis (BIA) to predict total body water (TBW) was assessed in 16 underweight [< 95% of ideal body weight (IBW)] and 25 normal-weight (> 95% of IBW) cancer patients. Although height2/resistance (ht2/R) proved to be a strong single predictor of TBW measured by deuterium dilution in both groups (normal-weight patients: r2 = 0.85, SEE 2.16 L; underweight patients: r2 = 0.86, SEE 2.24 L), TBW would be significantly overestimated in the underweight group if the prediction formula developed in the normal-weight group was used [bias 1.67 L (5%), 95% CI 0.20-3.15 L]. A systematic overestimation of TBW in the underweight patients was also found when TBW was predicted in our two patient groups by several previously published BIA formulas developed in normal-weight individuals. We conclude therefore, that although a similar relationship is found between ht2/R and TBW in normal-weight and underweight cancer patients, single-frequency BIA overestimates TBW in underweight patients when prediction formulas are used that have been developed in normal-weight subjects.
authors.affiliation: Department of Pulmonology, University of Limburg, Maastricht, Netherlands.
authors.forename: J P
authors.initials: JP
authors.lastname: Simons
authors.forename: A M
authors.initials: AM
authors.lastname: Schols
authors.forename: K R
authors.initials: KR
authors.lastname: Westerterp
authors.forename: G P
authors.initials: GP
authors.lastname: ten Velde
authors.forename: E F
authors.initials: EF
authors.lastname: Wouters
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D000368:Aged; D000818:Animals; D001823:Body Composition; D001834:Body Water; D001835:Body Weight; D002100:Cachexia / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D003903:Deuterium; D017097:Electric Impedance; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D012044:Regression Analysis; D015431:Weight Loss
chemical_list: D003903:Deuterium