title: Focal dystonia and speech impairment responding to anticholinergic therapy.
abstract: Focal dystonia of the right hand and speech impairment as a result of a circumscribed left-sided anterior thalamic lesion is reported in a 9-year-old girl with borderline normal psychomotor development. Both focal dystonia and speech impairment improved during anticholinergic treatment and worsened after drug withdrawal.
authors.affiliation: Institute of Neurology, Academic Hospital Nijmegen, The Netherlands.
authors.forename: O J
authors.initials: OJ
authors.lastname: Vogels
authors.forename: B
authors.initials: B
authors.lastname: Maassen
authors.forename: J J
authors.initials: JJ
authors.lastname: Rotteveel
authors.forename: J L
authors.initials: JL
authors.lastname: Merx
mesh_terms: D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D004421:Dystonia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D007807:Language Tests; D009460:Neurologic Examination / Q000187:drug effects; D013064:Speech Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D013068:Speech Production Measurement; D013786:Thalamic Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D014282:Trihexyphenidyl / Q000008:administration & dosage*
chemical_list: D014282:Trihexyphenidyl