Differential localization of mRNAs encoding dopamine D1 or D2 receptors in cholinergic neurons in the core and shell of the rat nucleus accumbens.
By combining immunocytochemistry for ChAT and in situ hybridization for dopamine D1 or D2 receptor mRNA in the striatum, it was found that (1) the percentage of ChAT/D2 mRNA co-localization is higher in the caudate-putamen than in the shell and core of the nucleus accumbens, (2) in the shell the degree of ChAT/D2 mRNA co-localization is higher rostrally than caudally, and 3) no significant regional differences exist in the degree of co-localization of ChAT and D1 mRNA.
Jongen-Rêlo
A L
AL
Graduate School of Neurosciences Amsterdam, Vrije Universiteit, Faculty of Medicine, Department of Anatomy and Embryology, The Netherlands.
Docter
G J
GJ
Jonker
A J
AJ
Voorn
P
P
D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D009714:Nucleus Accumbens / Q000737:chemistry* / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000096:biosynthesis / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis / Q000378:metabolism*
D012333:RNA, Messenger; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2