title: Effectiveness and safety of multidrug intracavernous therapy for vasculogenic impotence.
abstract: A four-drug vasoactive mixture (papaverine hydrochloride, prostaglandin E1, phentolamine mesylate, atropine sulfate) was used for intracavernous injection therapy in 94 patients with vasculogenic impotence as diagnosed by color Doppler sonography and dynamic infusion cavernosometry-cavernosography. At a mean follow-up of twenty months, 66 patients (70%) are using the injections with the initial dose and are satisfied; 14 patients (15%) are using the injections with a smaller dose than initially given; and 14 patients (15%) dropped intracavernous treatment. Only 4 patients (4%) were unable to achieve a sustained rigid erection during the mixture titration phase. Selected cases of vasculogenic impotence can be safely and effectively treated by the association of drugs which rely on different mechanisms of action, producing a pharmacologic synergism which enhances the overall therapeutic effect.
authors.affiliation: Institute of Human Anatomy, Scientific Institut H. San Raffaele, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Montorsi
authors.forename: G
authors.initials: G
authors.lastname: Guazzoni
authors.forename: F
authors.initials: F
authors.lastname: Bergamaschi
authors.forename: A
authors.initials: A
authors.lastname: Dodesini
authors.forename: P
authors.initials: P
authors.lastname: Rigatti
authors.forename: G
authors.initials: G
authors.lastname: Pizzini
authors.forename: A
authors.initials: A
authors.lastname: Miani
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage; D001285:Atropine / Q000008:administration & dosage; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010208:Papaverine / Q000008:administration & dosage; D010413:Penis / Q000098:blood supply*; D010646:Phentolamine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D001285:Atropine; D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine