Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer.
Restriction enzyme digests of genomic DNA show multiple alleles of common, intermediate, and rare frequencies at the minisatellite locus of Ha-ras. It has been suggested that a higher frequency of rare alleles is associated with the presence of colorectal and other types of cancer. This study investigated the distribution of Ha-ras alleles in 40 members of hereditary non-polyposis colorectal carcinoma (HNPCC) families and in 34 cancer free subjects (spouses). There was no difference in rare allele frequency between the cancer group and cancer free group (chi2 = 0.25, not significant).
Jeevaratnam
P
P
Department of Molecular Medicine and Pathology, School of Medicine, University of Auckland, New Zealand.
Browett
P J
PJ
Van de Water
N S
NS
Jass
J R
JR
D000483:Alleles; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D005787:Gene Frequency; D011905:Genes, ras; D006801:Humans; D017403:In Situ Hybridization; D012307:Risk Factors