Lectin staining of the endothelial cell membrane is more sensitive to ultraviolet radiation than the epidermal cell staining in guinea-pig skin.
Ultraviolet radiation (UVR)-induced alterations in lectin stainings of both endothelial and epidermal cells were histochemically analysed in guinea-pig skin using Bandeiraea simplicifolia agglutinin-I and Ricinus communis agglutinin-I. The endothelial cell staining with both lectins was more sensitive to a single exposure to middle-wave UVR (UVB) and topical psoralen plus long-wave UVR (UVA) (PUVA) than the epidermal cell staining. More remarkable changes were seen following PUVA radiation than UVB radiation. No significant alterations were induced by UVA radiation alone or psoralen alone. The results suggest that the endothelial cell is a susceptible target for UVB and PUVA radiation.
Sayeed
Q K
QK
Department of Dermatology, Kyoto University Faculty of Medicine, Japan.
Danno
K
K
Horiguchi
Y
Y
Imamura
S
S
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000528:radiation effects; D004727:Endothelium / Q000378:metabolism / Q000528:radiation effects; D004817:Epidermis / Q000378:metabolism* / Q000528:radiation effects*; D005363:Ficusin / Q000494:pharmacology; D006168:Guinea Pigs; D006651:Histocytochemistry; D037102:Lectins; D011701:PUVA Therapy; D012867:Skin / Q000378:metabolism* / Q000528:radiation effects*; D013194:Staining and Labeling; D014466:Ultraviolet Rays
D037102:Lectins; D005363:Ficusin