The role of vitamin D in toxic metal absorption: a review.
Vitamin D increases intestinal calcium and phosphate absorption. Not so well known, however, is that vitamin D stimulates the co-absorption of other essential minerals like magnesium, iron, and zinc; toxic metals including lead, cadmium, aluminum, and cobalt; and radioactive isotopes such as strontium and cesium. Vitamin D may contribute to the pathologies induced by toxic metals by increasing their absorption and retention. Reciprocally, lead, cadmium, aluminum, and strontium interfere with normal vitamin D metabolism by blocking renal synthesis of 1,25-dihydroxyvitamin D. This is the first review of the role of the vitamin D endocrine system in metal toxicology.
Moon
J
J
National College of Naturopathic Medicine, Portland Oregon 97216.
D000535:Aluminum / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D001822:Body Burden; D002104:Cadmium / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D007854:Lead / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology; D013326:Strontium Radioisotopes / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology*
D013326:Strontium Radioisotopes; D002104:Cadmium; D014807:Vitamin D; D007854:Lead; D000535:Aluminum