The pharmacokinetics of once daily gentamicin in neutropenic adults with haematological malignancy.
Seven febrile neutropenic adults with normal renal function were treated with intravenous gentamicin 4.5 mg/kg once a day in combination with azlocillin. Gentamicin serum concentrations 1, 2, 4, 8, and 24 h after a 30 min infusion were 10.9 +/- 0.6, 7.1 +/- 0.4, 4.2 +/- 0.2, 1.8 +/- 0.1 and 0.16 +/- 0.003 mg/L respectively. The pharmacokinetics were best described by a triphasic plot including a distribution phase (about 1/2 h) and two elimination phases, an early and late.
MacGowan
A P
AP
Department of Medical Microbiology, Southmead Health Services NHS Trust, Westbury-on-Trym, Bristol, UK.
Bedford
K A
KA
Blundell
E
E
Brown
N M
NM
Habib
F
F
Hows
J
J
Kirkpatrick
B
B
Korner
R J
RJ
Slade
R R
RR
White
L O
LO
D000293:Adolescent; D000328:Adult; D000368:Aged; D001390:Azlocillin / Q000008:administration & dosage; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy* / Q000378:metabolism
D005839:Gentamicins; D001390:Azlocillin