title: Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains.
abstract: Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.
authors.affiliation: School of Biological Sciences, University of Surrey, Guildford, UK.
authors.forename: M M
authors.initials: MM
authors.lastname: Willcocks
authors.forename: J B
authors.initials: JB
authors.lastname: Kurtz
authors.forename: T W
authors.initials: TW
authors.lastname: Lee
authors.forename: M J
authors.initials: MJ
authors.lastname: Carter
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002213:Capsid / Q000737:chemistry* / Q000235:genetics; D005814:Genes, Viral; D006801:Humans; D001257:Mamastrovirus / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012703:Serotyping; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D015678:Viral Structural Proteins