No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study.
A possible association between body iron stores, measured as serum ferritin, and carotid arterial intima-media thickening was investigated in the Atherosclerosis Risk in Communities Study during 1990-1992 using a matched case-control design. For a 143-micrograms/liter greater serum ferritin concentration (the interquartile range), the odds ratio for cases with carotid intima-media thickening versus controls was 1.12 (95% confidence interval 0.97-1.30). However, there was no association (odds ratio = 1.00) after adjusting for major cardiovascular risk factors. This analysis of carotid arterial intima-media thickening, a measure of early atherosclerosis, in relation to serum ferritin does not support the hypothesis that increased body iron stores increase the risk of atherosclerotic cardiovascular disease.
Moore
M
M
Mayo Graduate School of Medicine, Rochester, MN, USA.
Folsom
A R
AR
Barnes
R W
RW
Eckfeldt
J H
JH
D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D002340:Carotid Artery Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology
D005293:Ferritins; D007501:Iron