Role of genetic factors in drug-related autoimmunity.
Although there is evidence to suggest that genetic factors play a major role in the pathogenesis of many of the rheumatic diseases, far less is known of their role in the induction and expression of human autoimmunity resulting from long-term exposure to drugs, chemicals and environmental agents. Pharmacogenetic factors represent an important source of interindividual variation in response to drugs; most research to date has focused on genetic polymorphism of drug metabolism via N-acetylation, S-methylation or cytochrome P-450-catalyzed oxidation. In drug-related autoimmunity, there is limited evidence that the host's genetic background plays a major role beyond the expression of autoantibodies. More recent prospective studies have concentrated on the association of MHC-genes in the expression of autoimmunity and the susceptibility of patients to develop drug-related clinical syndromes.
Adams
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LE
Department of Medicine, Hoxworth Blood Center, University of Cincinnati Medical Center, Ohio 45267-0563.
Mongey
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AB
D000107:Acetylation; D000818:Animals; D001327:Autoimmune Diseases / Q000139:chemically induced*; D015551:Autoimmunity / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens