Effect of orally administered heat-killed Enterococcus faecalis FK-23 preparation on leukopenia in mice treated with cyclophosphamide.
Cyclophosphamide (CY) treated mice were orally administered heat-killed Enterococcus faecalis FK-23 preparation (FK-23) to define the effect of FK-23 on leukopenia associated with chemotherapy. FK-23 had no inhibiting effect on CY induced leukopenia, whereas it augmented leukocyte reconstitution in CY-treated mice. The percentage of neutrophils increased in the mice orally given FK-23. Furthermore, an increase in a myeloid/erythroid ratio and neutrophilic lineages was found in bone marrow of FK-23 treated mice. These findings suggest that FK-23 may have a potent effect on the augmentation of leukocyte reconstituting capacity in patients receiving chemotherapy.
Hasegawa
T
T
Veterinary Teaching Hospital, Faculty of Agriculture, Miyazaki University, Japan.
Ogura
Y
Y
Inomata
T
T
Murakumo
Y
Y
Yamamoto
T
T
Abe
S
S
Yamaguchi
H
H
D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003520:Cyclophosphamide; D013293:Enterococcus faecalis / Q000276:immunology*; D005260:Female; D007970:Leukopenia / Q000139:chemically induced / Q000628:therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D015164:Vaccines, Inactivated / Q000627:therapeutic use
D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated; D003520:Cyclophosphamide