Dark interaction of haematoporphyrin and proflavine with Salmonella dublin cells.
The influence of haematoporphyrin and proflavine on the virulence, survivability, respiratory activity and cell wall ultrastructure of Salmonella dublin cells was studied. There was a decrease in all biological properties investigated, especially when haematoporphyrin was used for dark incubation in comparison with proflavine. The possible clinical use of negatively charged photosensitizers is discussed.
Veljanov
D
D
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.
Kussovski
V
V
Radoucheva
T
T
Najdenski
H
H
Ilieva
L
L
Cherepova
N
N
Voivodov
K
K
Genov
N
N
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D003624:Darkness; D006415:Hematoporphyrins / Q000494:pharmacology*; D008027:Light; D051379:Mice; D011370:Proflavine / Q000494:pharmacology*; D012475:Salmonella / Q000472:pathogenicity / Q000502:physiology* / Q000648:ultrastructure; D014774:Virulence / Q000187:drug effects
D006415:Hematoporphyrins; D011370:Proflavine; C039137:O,O'-diacetylhematoporphyrin