title: The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats.
abstract: The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation behavior was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.
authors.affiliation: Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Mintz
authors.forename: I
authors.initials: I
authors.lastname: Gordon
authors.forename: N
authors.initials: N
authors.lastname: Roz
authors.forename: M
authors.initials: M
authors.lastname: Rehavi
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001692:Biological Transport; D002352:Carrier Proteins / Q000187:drug effects* / Q000502:physiology; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D050483:Dopamine Plasma Membrane Transport Proteins; D004334:Drug Administration Schedule; D005260:Female; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects*; D009419:Nerve Tissue Proteins; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D003913:Dextroamphetamine