Helioferins; novel antifungal lipopeptides from Mycogone rosea: screening, isolation, structures and biological properties.
Helioferins A and B were detected as novel aminolipopeptides in cultures of Mycogone rosea DSM 8822 in the course of a screening for mediators of helianthate anion transfer from aqueous to toluene phases. Their structures as novel antibiotics and cytotoxic agents were elucidated by mass spectrometry and NMR spectroscopic methods. Antimicrobial activity was estimated against Candida albicans and Gram-positive bacteria including Mycobacterium spp.
Gräfe
U
U
Hans-Knöll-Institute of Natural Product Research, Jena Germnay.
Ihn
W
W
Ritzau
M
M
Schade
W
W
Stengel
C
C
Schlegel
B
B
Fleck
W F
WF
Künkel
W
W
Härtl
A
A
Gutsche
W
W
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010455:Peptides