[S-nitrosothiols and dinitrosothiol iron complexes as a source of nitric oxide in animals].
It was established by EPR method, that S-nitrosocysteine or S-nitrosohomocysteine rapid destructured with releasing nitric oxide (NO) in blood, forming with hemoglobin paramagnetic hemoglobin nitrosyl complexes (Hb-NO). In the presence of exogenous iron in blood dinitrosyl non-heme iron complexes (DNIC) with thiol-containing ligands, i.e. 2,03 complexes arose in blood. These complexes occurred in large quantity if it was introduced to animals low molecular DNIC with cysteine or homocysteine in relation iron/thiol in complexes and solution 1:20 or 1:2. 2,03 complexes in organisms was stable. So, the system of DNIC S-nitrosothiols prevailed the S-nitrosothiols conversation into DNIC.
Khrapova
N V
NV
Malenkova
I V
IV
Vanin
A F
AF
D000818:Animals; D001711:Biotransformation; D003545:Cysteine / Q000031:analogs & derivatives* / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D009569:Nitric Oxide / Q000096:biosynthesis*; D009603:Nitroso Compounds / Q000378:metabolism*; D026403:S-Nitrosothiols
D009603:Nitroso Compounds; D026403:S-Nitrosothiols; D006710:Homocysteine; C079202:S-nitrosohomocysteine; D009569:Nitric Oxide; C021315:S-nitrosocysteine; D007501:Iron; D003545:Cysteine