[A case of pulmonary infiltrates associated with a neutrophil-specific antibody transfusion reactions].
A normovolemic pulmonary edema associated with blood transfusion developed in a 38-year-old woman during gynecological operation. Bilateral pulmonary infiltrates and profound leucopenia (700.microliters-1) were observed. An antibody reactive with the recipient's neutrophils was found in a donor and an antibody reacting with the lymphocytes of the recipient was identified in another donor. Both donors were multiparous women. Respiratory failure was improved with mechanical ventilation but chest X-ray showed pulmonary infiltrates for the next 3 days. The white blood cell count rose to 2900.microliters-1 in the next day, and it took 2 weeks to be normalized. Transient pulmonary infiltrates can be caused by antileukocyte antibodies passively transfused by multiparous donors.
Kan
K
K
Department of Anesthesiology, Fukushima Medical College.
Tase
C
C
Ohto
H
H
Isosu
T
T
Niitsu
K
K
D000328:Adult; D000773:Anesthesia, Obstetrical; D000918:Antibody Specificity; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies; D007970:Leukopenia / Q000209:etiology*; D009504:Neutrophils / Q000276:immunology*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000601:surgery; D011654:Pulmonary Edema / Q000209:etiology*; D065227:Transfusion Reaction
D006680:HLA Antigens; D007518:Isoantibodies