Galanin-induced growth hormone secretion in conscious rats: evidence for a possible involvement of somatostatin.
Intracerebroventricular administration of galanin (GAL) potently evoked growth hormone (GH) secretion in conscious male rats. Pretreatments with neostigmine and cysteamine blunted the GAL-induced GH secretion. Pretreatment of animals with a specific anti-somatostatin serum significantly inhibited the GAL-induced GH secretion. On the contrary, GH-releasing hormone-induced GH secretion was significantly enhanced with cysteamine and anti-somatostatin serum. These results suggest that somatostatin is involved in GAL-induced GH secretion in rats.
Tanoh
T
T
Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.
Shimatsu
A
A
Ishikawa
Y
Y
Ihara
C
C
Yanaihara
N
N
Imura
H
H
D000818:Animals; D003543:Cysteamine / Q000494:pharmacology; D019004:Galanin; D013006:Growth Hormone / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D010455:Peptides / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000502:physiology*
D010455:Peptides; D009388:Neostigmine; D013004:Somatostatin; D003543:Cysteamine; D019004:Galanin; D013006:Growth Hormone