title: Influence of chronic mercury poisoning upon the connective tissue in rats. I. Effect of mercuric chloride on glycosaminoglycan levels in tissues, serum and urine.
abstract: Rats were intoxicated with mercuric chloride (1mg/kg b.w.) daily, for 12 weeks. A decrease in total glycosaminoglycan content was shown in the skin, the lungs, the liver and the heart muscle. These changes were accompanied by a slight alteration of the glycosaminoglycan pattern, a decrease in hyaluronic acid in the skin, the lungs and the heart muscle and an enhancement of heparan sulphate level in the kidneys. In serum of mercury-intoxicated rats, an increase in total glycosaminoglycan levels was shown. This enhancement was caused by elevation of almost all fractions. Urine output of glycosaminoglycans was higher in mercury-treated animals as compared to the controls.
authors.affiliation: Department of Clinical Chemistry, Silesian University School of Medicine, Katowice, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Olczyk
authors.forename: E J
authors.initials: EJ
authors.lastname: Kucharz
authors.forename: A
authors.initials: A
authors.lastname: Głowacki
mesh_terms: D000818:Animals; D002908:Chronic Disease; D006025:Glycosaminoglycans / Q000032:analysis / Q000378:metabolism; D008297:Male; D008627:Mercuric Chloride / Q000097:blood / Q000633:toxicity* / Q000652:urine; D008630:Mercury Poisoning / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D006025:Glycosaminoglycans; D008627:Mercuric Chloride