title: Relation between myocardial uptake of thallium-201 chloride and fluorine-18 fluorodeoxyglucose imaged with single-photon emission tomography in normal individuals.
abstract: Recently, we have demonstrated the feasibility of imaging myocardial uptake of fluorine-18 fluorodeoxyglucose (FDG) with single-photon emission tomography (SPET) using a specially designed collimator. Thallium-201 was used to determine distribution of perfusion for comparison with FDG uptake. However, regional 201Tl and FDG activities may be different, based on differences in tracer attenuation and the use of different collimators. To study the relation between tracer activities imaged with SPET, nine healthy individuals underwent resting 201Tl SPET and FDG SPET during a hyperinsulinaemic euglycaemic clamp. The SPET data were analysed semiquantitatively, using circumferential profiles. Mean profiles of midventricular short-axis slices showed no significant difference between 201Tl and FDG activity. Regional fluctuations were similar for FDG and 201Tl; the highest tracer activities were observed in the lateral wall and the lowest activities in the septum. Finally, pooled data (n = 1620 segmental activities) in nine individuals showed a linear correlation (P < 0.0001) between 201Tl and FDG activity: FDG = 0.76 201Tl + 0.23 (r = 0.70). These data demonstrate the absence of major differences between regional 201Tl and FDG activity in normal myocardium, suggesting that no separate 201Tl and FDG SPET reference values are needed for comparison with patient studies.
authors.affiliation: Department of Cardiology, Free University Hospital Amsterdam, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Bax
authors.forename: F C
authors.initials: FC
authors.lastname: Visser
authors.forename: A
authors.initials: A
authors.lastname: van Lingen
authors.forename: A B
authors.initials: AB
authors.lastname: Groeneveld
authors.forename: J M
authors.initials: JM
authors.lastname: Huitink
authors.forename: G J
authors.initials: GJ
authors.lastname: Teule
authors.forename: C A
authors.initials: CA
authors.lastname: Visser
mesh_terms: D000328:Adult; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D015309:Glucose Clamp Technique; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism; D012016:Reference Values; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005462:Fluorine Radioisotopes; D013794:Thallium Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose