title: Oxygen radicals, cytokines, adhesion molecules, and lung injury.
abstract: Inflammatory injury in the lung or dermis occurring after systemic activation of complement or after local deposition of immune complexes is related to local activation of tissue macrophages and/or recruitment of blood neutrophils. While requirements for cytokines (IL-1, TNF alpha, MCP-1) vary with the model of injury, requirements for adhesion molecules (beta 2 integrins, selectins, ICAM-1) differ. In most cases the immediate events related to tissue injury can be linked to toxic products from oxygen and L-arginine. Whether there is a single toxic product or a variety of toxic products remains to be determined. These data emphasize similarities and differences in the mechanisms of inflammatory injury, as a function of the inciting inflammatory agent and the organ system involved.
authors.affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor 48109-0602.
authors.forename: P A
authors.initials: PA
authors.lastname: Ward
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D003167:Complement Activation; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008171:Lung Diseases / Q000209:etiology*; D017382:Reactive Oxygen Species; D012867:Skin / Q000098:blood supply; D014652:Vascular Diseases / Q000209:etiology
chemical_list: D000936:Antigen-Antibody Complex; D015815:Cell Adhesion Molecules; D016207:Cytokines; D007074:Immunoglobulin G; D017382:Reactive Oxygen Species