title: Dual T cell receptor beta chain expression on human T lymphocytes.
abstract: Allelic exclusion of lymphocyte antigen receptor chains has been hypothesized as a mechanism developed by the immune system to ensure efficient lymphocyte repertoire selection and tight control of lymphocyte specificity. It was effectively shown to be operative for both the immunoglobulin (Ig) and the T cell receptor (TCR) beta chain genes. Our present observations suggest that close to 1% of human T lymphocytes escape this allelic control, and express two surface TCR beta chains with distinct superantigenic reactivities. Since this high frequency of dual beta chain expressors did not result in any dramatic immune dysregulations, these results question the need for a mechanism ensuring clonal monospecificity through allelic exclusion.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U211, Institut de Biologie, Nantes, France.
authors.forename: F
authors.initials: F
authors.lastname: Davodeau
authors.forename: M A
authors.initials: MA
authors.lastname: Peyrat
authors.forename: F
authors.initials: F
authors.lastname: Romagné
authors.forename: A
authors.initials: A
authors.lastname: Necker
authors.forename: M M
authors.initials: MM
authors.lastname: Hallet
authors.forename: H
authors.initials: H
authors.lastname: Vié
authors.forename: M
authors.initials: M
authors.lastname: Bonneville
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology; D001483:Base Sequence; D002999:Clone Cells / Q000378:metabolism; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D006801:Humans; D018655:Lymphocyte Count; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis* / Q000235:genetics; D018089:Superantigens / Q000276:immunology; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens