Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas.
We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and, moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.
Sakamoto
S
S
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Taga
H
H
Uchikoshi
T
T
Kudo
H
H
Suzuki
S
S
Sugiura
Y
Y
Kuwa
K
K
Endo
Y
Y
D000284:Administration, Oral; D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects*; D004357:Drug Synergism; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008749:Methyldimethylaminoazobenzene; D051381:Rats; D013937:Thymidine Kinase / Q000096:biosynthesis*; D013940:Thymidylate Synthase / Q000096:biosynthesis*; D014498:Uracil / Q000008:administration & dosage / Q000494:pharmacology*; D000509:alpha-Fetoproteins / Q000096:biosynthesis
D004273:DNA, Neoplasm; D000509:alpha-Fetoproteins; D008749:Methyldimethylaminoazobenzene; D014498:Uracil; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D002945:Cisplatin