Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteins.
Mortalin has been shown to exhibit differential distributions in cells with mortal and immortal phenotypes. In the present study, we report mot-2 cDNA cloning from RS-4 cells--an immortal clone from CD1-ICR mouse embryonic fibroblasts--and the chromosomal assignments of mortalin related genes to mouse chromosomes 18 and X by fluorescence in situ hybridization. Similar analysis assigned the gene to chromosome 5q31.1 in human.
Kaul
S C
SC
National Institute of Bioscience and Human Technology, AIST, Ibaraki, Japan.
Wadhwa
R
R
Matsuda
Y
Y
Hensler
P J
PJ
Pereira-Smith
O M
OM
Komatsu
Y
Y
Mitsui
Y
Y
D000818:Animals; D016466:CHO Cells; D002352:Carrier Proteins; D002460:Cell Line; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D006224:Cricetinae; D004622:Embryo, Mammalian; D005347:Fibroblasts; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006360:Heat-Shock Proteins / Q000235:genetics*; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics*; D024101:Mitochondrial Proteins; D005810:Multigene Family; D014960:X Chromosome
D002352:Carrier Proteins; D018840:HSP70 Heat-Shock Proteins; C492001:HSPA9 protein, human; D006360:Heat-Shock Proteins; C083794:Hspa9 protein, mouse; D024101:Mitochondrial Proteins; C080352:mortalin