Triazolo[4,5-f]quinolines. Part VI. Synthesis and evaluation of 9-aminoalkyl(aryl)-2-methyl-2H-[4,5-f]quinolines as anticancer agents. Preliminary results of in vitro screening.
9-Aminoalkyl(aryl)-2-methyl-2H-triazolo[4,5-f] quinolines were prepared in order to evaluate their in vitro antitumor activity. Some members of this series exhibited both cell selectivity and tumor growth inhibition activity at concentrations between 10(-8) and 10(-4)M. In particular, compounds Ia,c,m,o,p and q showed percent growth near zero at midpoint between 10(-5) and 10(-4)M in most cell lines.
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Istituto di Chimica Farmaceutica e Tossicologica, Università di Sassari.
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D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D011804:Quinolines; D014230:Triazoles