Investigation of long-term hypocoagulability in rats after intratracheal administration of unfractionated heparin.
The comparative study of intratracheal and intravenous administration of heparin on blood coagulation and mast cell population was carried out in experiments in rats. Unlike the intravenous injection of heparin which induces fast short-time inactivation of all clotting factors, single intratracheal injection of heparin inactivated the intrinsic pathway of thrombin generation. Long-term hypocoagulability after intratracheal administration of heparin was related to the accumulation of heparin in mast cell.
Efimov
V S
VS
Russia State Medical University, Moscow.
Rumyantseva
A G
AG
Golovlyova
O A
OA
Rozkin MYa
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D004333:Drug Administration Routes; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008407:Mast Cells; D051381:Rats; D013194:Staining and Labeling; D014132:Trachea
D001779:Blood Coagulation Factors; D006493:Heparin