Ascorbic acid is cytotoxic for pediatric tumor cells cultured in vitro.
2 mM Ascorbic acid has a potent cytotoxic effect on neuroblastoma, osteosarcoma, retinoblastoma, and rhabdomyosarcoma cells cultured in vitro. At a lower concentration (0.2 mM), ascorbic acid remains highly cytotoxic for neuroblastoma, osteosarcoma and retinoblastoma cells, but it has a stimulatory effect on the growth of rhabdomyosarcoma cells.
Medina
M A
MA
Sektion Onkologie/Immunologie, Universitäts Kinderklinik, Ruprecht-Karls-Universität, Heidelberg, Germany.
García de Veas
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R
Schweigerer
L
L
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D003603:Cytotoxins; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003603:Cytotoxins; D001205:Ascorbic Acid