Studies on activation of H3 histamine receptor: a mechanistic model.
The recognition and the activation mechanism of the H3 histamine receptor was studied based on quantum-chemical calculations. A mechanistic model proposed both for recognition and activation stage clarifies different properties of histamine and alpha-methylhistamine at the H3 receptor. Interaction with a hypothetical receptor sites leads to the opening of the intramolecular hydrogen bonding in histamine, whereas the alpha-methylhistamine remains in closed conformation.
Karpińska
G
G
Drug Institute, Warsaw, Poland.
Mazurek
A P
AP
D006632:Histamine / Q000737:chemistry / Q000378:metabolism*; D008761:Methylhistamines / Q000737:chemistry / Q000378:metabolism*; D008956:Models, Chemical; D008968:Molecular Conformation; D011789:Quantum Theory; D018100:Receptors, Histamine H3 / Q000737:chemistry / Q000502:physiology*; D013816:Thermodynamics
D008761:Methylhistamines; D018100:Receptors, Histamine H3; C069357:alpha-methylhistamine; D006632:Histamine