title: Positive-ion fast-atom bombardment tandem mass spectrometry of peptide nucleic acids.
abstract: The base sequence of synthetic peptide nucleic acids (PNAs), novel antisense agents, was analyzed by positive-ion fast-atom bombardment tandem mass spectrometry (FAB-MS/MS). Upon high-energy collisional activation decomposition, PNA oligomers provided apparent MS/MS product ions resulting from specific cleavage along the PNA backbone.
authors.affiliation: Institute for Protein Research, Osaka University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takao
authors.forename: H
authors.initials: H
authors.lastname: Fukuda
authors.forename: J
authors.initials: J
authors.lastname: Coull
authors.forename: Y
authors.initials: Y
authors.lastname: Shimonishi
mesh_terms: D001483:Base Sequence; D008969:Molecular Sequence Data; D009696:Nucleic Acids / Q000032:analysis* / Q000138:chemical synthesis; D010455:Peptides / Q000032:analysis* / Q000138:chemical synthesis; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D009696:Nucleic Acids; D010455:Peptides