title: Early components of transcallosal responses in acute ischaemia of the corpus callosum.
abstract: In 8 baboons maintained under propofol anaesthesia, transcallosal evoked responses were recorded from the primary motor cortex following electrical stimulation of the contralateral homotopic cortical surface. The corpus callosum was made ischaemic by transorbital occlusion of the common anterior cerebral artery; blood flow (measured by the hydrogen clearance method) in the stimulating and recording regions was not significantly affected by this procedure. The transcallosal responses from the normally perfused brain contained early positive (P1) and negative (N1) components. As stepwise ischaemia was produced in the corpus callosum, the amplitude of P1 initially increased up to 150% of control and the peak latency of P1 was significantly prolonged. At flows below 8 ml/100 g/min the amplitude rapidly decreased. Wave form changes and flow threshold of N1 were similar to those of P1. These results suggest that measurement of early transcallosal responses could be useful clinically as monitors of the ischaemic level in anterior cerebral artery territory.
authors.affiliation: Gough-Cooper Department of Neurological Surgery, Institute of Neurology, London, UK.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: N M
authors.initials: NM
authors.lastname: Branston
authors.forename: L
authors.initials: L
authors.lastname: Symon
mesh_terms: D000208:Acute Disease; D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003337:Corpus Callosum / Q000098:blood supply / Q000503:physiopathology*; D004558:Electric Stimulation; D004569:Electroencephalography; D010215:Papio; D011930:Reaction Time / Q000502:physiology