title: N-(indol-3-ylglyoxylyl)amino acid ester derivatives. Synthesis and interaction properties at the benzodiazepine receptor.
abstract: Several N-(indol-3-ylglyoxylyl)alanine and glycine ester derivatives were prepared to evaluate the influence of the ester group size both on affinity and on activity at the benzodiazepine receptor. Moreover, indol-3-ylglyoxylic acid esters, closely related to 3-alkoxy-beta-carbolines, were synthesized and tested in vitro on the benzodiazepine receptor.
authors.affiliation: Istituto Policattedra di Discipline Biologiche dell'Università di Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Primofiore
authors.forename: F
authors.initials: F
authors.lastname: Da Settimo
authors.forename: A M
authors.initials: AM
authors.lastname: Marini
authors.forename: C
authors.initials: C
authors.lastname: La Motta
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: G
authors.initials: G
authors.lastname: Senatore
authors.forename: A
authors.initials: A
authors.lastname: Lucacchini
mesh_terms: D000818:Animals; D002417:Cattle; D005445:Flunitrazepam / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis* / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D011963:Receptors, GABA-A; D005445:Flunitrazepam