Substance P and inflammatory pain: potential of substance P antagonists as analgesics.
Substance P has been implicated in peripheral inflammatory responses and recent evidence from animal models indicates that substance P (NK-1 receptor) antagonists are effective in blocking peripheral inflammatory responses as well as nociception (pain) associated with inflammation. Evidence implicating substance P in nociception is reviewed in this survey, along with evidence on the effects of NK-1 receptor antagonists and with some comments on the usefulness of such antagonists as analgesics.
Henry
J L
JL
Department of Physiology, McGill University, Montreal, Quebec, Canada.
D000818:Animals; D004594:Electrophysiology; D006801:Humans; D007249:Inflammation / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology; D013373:Substance P / Q000037:antagonists & inhibitors* / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D013373:Substance P