Age-related alterations of the blood-brain-barrier (bbb) permeability to protein molecules of different size.
Transfer processes of differently sized protein molecules across the blood-brain-barrier (bbb) were studied in "normal" , respectively, diseased elderly humans. Lumbar CSF/serum ratio of albumin contents increased significantly with age in a control group, but it was diminished in patients suffering from inflammatory or non-inflammatory diseases. Ratio of alpha 2-macroglobulin contents increased with age, especially in the diseased elderly. Concentration ratios of lysozyme, orosomucoid, lactoferrin, IgG, IgA and IgM decreased with age in a control group and especially decreased in a patient group. The data are discussed with respect to two different transfer processes which appeared to be altered in age and/or disease processes.
Kleine
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TO
Funktionsbereich Neurochemie im Med. Zentrum für Nervenheilkunde, Universität Marburg a.d. Lahn, Germany.
Hackler
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R
Zöfel
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P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000134:cerebrospinal fluid*; D001798:Blood Proteins / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000502:physiology; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D007781:Lactoferrin / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000134:cerebrospinal fluid; D009961:Orosomucoid / Q000134:cerebrospinal fluid; D012016:Reference Values; D012709:Serum Albumin / Q000134:cerebrospinal fluid; D013129:Spinal Puncture; D000511:alpha-Macroglobulins / Q000134:cerebrospinal fluid
D001798:Blood Proteins; D007136:Immunoglobulins; D009961:Orosomucoid; D012709:Serum Albumin; D000511:alpha-Macroglobulins; D009113:Muramidase; D007781:Lactoferrin