The induction and suppression of c-fos expression in the rat brain by cholecystokinin and its antagonist L364,718.
Immunohistochemical techniques were used to map c-fos expression in the rat brain after the i.p. administration of CCK-8 (8 micrograms/kg). C-fos expression was observed in the rostral and the caudal parts of the nuclei of the solitary tract (NTS), and the paraventricular nuclei (PVN) in the hypothalamus. The c-fos expression in these areas was suppressed by the administration of L364,718 (120 micrograms/kg). Since L364,718 is known to be a powerful selective antagonist to the peripheral CCK-A receptors, these data suggest that the effects produced by exogenous CCK are due to peripheral receptors that project to the NTS.
Chen
D Y
DY
Department of Psychology, University of California, San Diego, La Jolla 92093.
Deutsch
J A
JA
Gonzalez
M F
MF
Gu
Y
Y
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D020109:Devazepide; D007150:Immunohistochemistry / Q000379:methods; D008526:Medulla Oblongata / Q000378:metabolism / Q000648:ultrastructure; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism / Q000648:ultrastructure; D016760:Proto-Oncogene Proteins c-fos / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D013194:Staining and Labeling
D001570:Benzodiazepinones; D016760:Proto-Oncogene Proteins c-fos; D020109:Devazepide; D012844:Sincalide