[The search for new antiallergy compounds among a number of coumarin derivatives and the study of their mechanisms of action].
The antiallergic effects of new novel synthetic coumarine-3-carboxylic acid derivatives were studied in a rat model of passive cutaneous anaphylaxis. The most potent agent was found and tested for mechanisms of its specific pharmacological action. Its capacity of suppressing immediate hypersensitivity in various animal species was demonstrated to be due to its concomitant action on the pathochemical and pathophysiological stages of the allergic process.
Saraf
A S
AS
Simonian
A V
AV
Oganesian
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ET
D000707:Anaphylaxis / Q000188:drug therapy / Q000276:immunology; D000818:Animals; D001986:Bronchial Spasm / Q000188:drug therapy / Q000276:immunology; D003374:Coumarins / Q000737:chemistry / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D006969:Hypersensitivity, Immediate / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
D003374:Coumarins