title: Expression of TRPM-2 during involution and regeneration of the rat liver.
abstract: Increased message levels of testosterone-repressed prostate message-2 (TRPM-2) have been associated with programmed cell death in many tissues. To study its involvement in the apoptotic elimination of hepatocytes during liver involution and regeneration, levels of TRPM-2 message were evaluated in situ and by the ribonuclease protection assay. Although significant increases in apoptotic bodies were observed in rats 96 h following treatment with lead nitrate and ethylene dibromide, an increase in TRPM-2 message was not detected. Therefore, the expression of TRPM-2 mRNA may be a poor indicator of the extent to which apoptosis occurs during liver involution.
authors.affiliation: Toxicology Research Laboratories, Lilly Research Laboratories (a Division of Eli Lilly and Company), Greenfield, Indiana 46140.
authors.forename: L M
authors.initials: LM
authors.lastname: Helvering
authors.forename: K K
authors.initials: KK
authors.lastname: Richardson
authors.forename: D M
authors.initials: DM
authors.lastname: Horn
authors.forename: K A
authors.initials: KA
authors.lastname: Wightman
authors.forename: R L
authors.initials: RL
authors.lastname: Hall
authors.forename: W C
authors.initials: WC
authors.lastname: Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Engelhardt
authors.forename: F C
authors.initials: FC
authors.lastname: Richardson
mesh_terms: D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D051152:Clusterin; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D017403:In Situ Hybridization; D008115:Liver Regeneration; D008297:Male; D018832:Molecular Chaperones; D012313:RNA / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D013194:Staining and Labeling
chemical_list: D051152:Clusterin; D006023:Glycoproteins; D018832:Molecular Chaperones; D012313:RNA