Genetic and neurobiological basis of alcohol-seeking behavior.
Through selective breeding, rat lines exhibiting high and low alcohol drinking preference have been developed as useful animal models for studying the neurobiological basis of alcohol-seeking behavior. The identified differences between lines in neurotransmitter functioning allows the evaluation of receptor agonist/antagonist compounds that might be efficacious in the treatment of alcohol craving and dependence.
Li
T K
TK
Indiana University School of Medicine, Indianapolis.
Lumeng
L
L
McBride
W J
WJ
Murphy
J M
JM
D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000503:physiopathology; D005260:Female; D008297:Male; D008957:Models, Genetic; D018377:Neurotransmitter Agents / Q000235:genetics* / Q000502:physiology; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000235:genetics* / Q000502:physiology; D012641:Selection, Genetic
D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter