title: Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.
abstract: The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 microM) and free radical release in whole blood (47 microM), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.
authors.affiliation: Sphinx Pharmaceuticals Corporation, Durham, North Carolina 27717.
authors.forename: P
authors.initials: P
authors.lastname: Kulanthaivel
authors.forename: W P
authors.initials: WP
authors.lastname: Janzen
authors.forename: L M
authors.initials: LM
authors.lastname: Ballas
authors.forename: J B
authors.initials: JB
authors.lastname: Jiang
authors.forename: C Q
authors.initials: CQ
authors.lastname: Hu
authors.forename: J W
authors.initials: JW
authors.lastname: Darges
authors.forename: J C
authors.initials: JC
authors.lastname: Seldin
authors.forename: D J
authors.initials: DJ
authors.lastname: Cofield
authors.forename: L M
authors.initials: LM
authors.lastname: Adams
mesh_terms: D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013267:Stilbenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D013267:Stilbenes; D011493:Protein Kinase C