Expression of a mucociliary-specific epitope in human olfactory epithelium.
An olfactory ciliary-specific epitope was localized immunohistochemically in the mucociliary complex of human olfactory epithelium of 12 subjects ranging in age from 16 weeks of gestation to 85 years, including 3 with Alzheimer's disease. Immunoreactivity for olfactory marker protein (OMP) was used to identify olfactory epithelium; OMP immunoreactivity in olfactory receptor neurons in a 16-week old fetus is the earliest time point at which OMP expression has been detected in human gestation. The results suggest a close coupling between the expression of ciliary molecules associated with odorant transduction and the functional maturation of olfactory receptor neurons.
Getchell
T V
TV
Department of Physiology and Biophysics, Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington 40536.
Chen
Y
Y
Strotmann
J
J
Breer
H
H
Getchell
M L
ML
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015415:Biomarkers; D002923:Cilia / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008875:Middle Aged; D009831:Olfactory Mucosa / Q000166:cytology / Q000254:growth & development / Q000276:immunology*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology
D015415:Biomarkers; D000939:Epitopes