Evidence for two neurochemical divisions in the human nucleus accumbens.
The neurochemical anatomy of the human nucleus accumbens was studied by comparing the distributional patterns of [3H]DAMGE (mu opioid receptor), [3H]bremazocine (kappa opioid receptor), [3H]SCH-23390 (D1-like dopamine receptor), [3H]7-OH-DPAT (D3 dopamine receptor) binding, preproenkephalin mRNA and acetylcholinesterase activity in sections of post mortem human striatum. Our results demonstrate the presence of at least two neurochemically distinct divisions within the human nucleus accumbens, which may be homologous to the 'shell' and 'core' divisions of the nucleus as found in the rat.
Voorn
P
P
Vrije Universiteit, Department of Anatomy and Embryology, Amsterdam, Netherlands.
Brady
L S
LS
Schotte
A
A
Berendse
H W
HW
Richfield
E K
EK
D000110:Acetylcholinesterase / Q000378:metabolism; D000700:Analgesics / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology; D001575:Benzomorphans / Q000494:pharmacology; D003720:Densitometry; D018491:Dopamine Agonists / Q000494:pharmacology; D004745:Enkephalins / Q000096:biosynthesis; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D011498:Protein Precursors / Q000096:biosynthesis; D017473:Receptors, Opioid, kappa / Q000187:drug effects; D017450:Receptors, Opioid, mu / Q000187:drug effects; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D000700:Analgesics; D001552:Benzazepines; D001575:Benzomorphans; D018491:Dopamine Agonists; D004745:Enkephalins; D011498:Protein Precursors; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D013764:Tetrahydronaphthalenes; C033660:preproenkephalin; D000110:Acetylcholinesterase; C027248:bremazocine; C031349:7-hydroxy-2-N,N-dipropylaminotetralin