Effect of L-type calcium channel modulators on stimulant-induced hyperactivity.
The present study investigated the effect of L-type calcium channel modulators on stimulant-induced locomotor activity. The L-channel activator, (+/-)BayK8644, produced a marked, long-lasting enhancement of cocaine-induced activity, while having no effect on amphetamine hyperactivity. Nicardipine reduced cocaine hyperactivity but had no effect on the amphetamine response.
Moore
N A
NA
Lilly Research Centre, Eli Lilly & Co., Windlesham, Surrey, U.K.
Rees
G
G
Sanger
G
G
Awere
S
S
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003042:Cocaine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004347:Drug Interactions; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009529:Nicardipine / Q000494:pharmacology; D051381:Rats
D002120:Calcium Channel Agonists; D002121:Calcium Channel Blockers; D000697:Central Nervous System Stimulants; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000661:Amphetamine; D009529:Nicardipine; D003042:Cocaine