title: Neurosurgical treatment of cranial base lesions: a review of historical advancement and current trends.
abstract: Cranial base lesions present a great challenge even to the most skilled neurosurgeon due to the difficulty of gaining access to the cranial base, the complex anatomical relations, hips of neurovascular structures involved in the pathology of the cranial base and bone destruction caused by tumors leaving intracranial space open to the respiratory and digestive tracts. With continuous advancements in microsurgical techniques and neuroradiological imaging, the removal of cranial base lesions has became a reality. Mortality rates of 50% or greater are today reduced to 10%, and previously very high morbidity rates today are acceptably low. The greatest acknowledgement in the advancement of cranial base lesions management must be given to the teamwork of neurosurgeons, radiologists, head and neck surgeons, otorhinolaryngologists and neuroophthalmologists.
authors.affiliation: Department of Neurosurgery, Sestre Milosrdnice University Hospital, Zagreb.
authors.forename: V
authors.initials: V
authors.lastname: Lupret
authors.forename: D
authors.initials: D
authors.lastname: Smiljanić
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis / Q000601:surgery; D006801:Humans