[The effect of certain factors on binding of tert-butyloxycarbonylamino acids to Merrifield polymer during interphase catalysis and assessment of racemization of the bound amino acid].
In order to reduce the influence of hydrogen bonds on the acylamino acid salts attachment to the chloromethylated resin, it is proposed to use compounds that can compete for the hydrogen bonds formation. The best solvent proved to be hexamethylphosphoric triamide. Use of interphase catalysts, e.g., tributyl-p-nitrobenzyl ammonium, also gives good results. The racemization degree of the amino acids attached to solid support by means of the interphase catalysis does not exceed that of amino acids loaded on the polymer according to Gisin's method.
Kulikov
S V
SV
Kolobov
A A
AA
Kampe-Nemm
E A
EA
Kazakov
G P
GP
Shpen'
V M
VM
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D006492:Hempa; D006860:Hydrogen Bonding; D008969:Molecular Sequence Data; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D011108:Polymers; D006492:Hempa