title: Effects of a short period of vitamin E-deficient diet in the turnover of different neurotransmitters in substantia nigra and striatum of the rat.
abstract: Measurement of turnover of dopamine, noradrenaline and serotonin and their metabolites was assessed in striatum and substantia nigra of adult female rats that were fed control or vitamin E-deficient diets over 15 days. The levels and turnover of dopamine increased and the levels of serotonin decreased in both structures whereas serotonin turnover decreased only in striatum. No change was found in the turnover rate of noradrenaline between control and experimental animals. However, the most striking result was the increase of dopamine turnover found in substantia nigra. This dopamine increase was accompanied by an increase in 3-methoxytyramine turnover which seems to indicate an increase in dopamine release after vitamin E deficiency. The present study indicates that the nigrostriatal dopamine neurons are susceptible to the deficiency of vitamin E. Moreover, these data suggest that substantia nigra may be more susceptible to damage from vitamin E deficiency than striatum.
authors.affiliation: Departamento de Bioquimica, Bromatologia y Toxicologia, Facultad de Farmacia, Universidad de Sevilla, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Castaño
authors.forename: A J
authors.initials: AJ
authors.lastname: Herrera
authors.forename: J
authors.initials: J
authors.lastname: Cano
authors.forename: A
authors.initials: A
authors.lastname: Machado
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000502:physiology; D003342:Corpus Striatum / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism; D004032:Diet; D004298:Dopamine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D004435:Eating; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000378:metabolism*
chemical_list: D018377:Neurotransmitter Agents; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline; C001746:3-methoxytyramine; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid