[Chloride channels in cardiac muscle].
This section describes properties, signal transduction pathways for activation and the physiological roles of cardiac Cl- channels. Recent application of patch clamp technics have revealed that a wide variety of Cl- channels are present in cardiac cells, which are regulated by different cellular stimuli, such as alpha 1- or beta-adrenoceptor stimulation, ATP, adenosine and cell swelling. When these channels are activated, Cl- is transported ECl-dependently in both inward and outward directions, affecting the action potential durations and/or resting potentials. Analysis of cardiac Cl- channel mechanisms yields new aspects for understanding pathophysiological bases of heart diseases or arrests such as arrhythmia.
Otani
H
H
Department of Pharmacology, Kansai Medical University.
Inagaki
C
C
D002712:Chlorides / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D002712:Chlorides; D007473:Ion Channels