title: Mycobacterium tuberculosis transmission rates in a sanatorium: implications for new preventive guidelines.
abstract: BACKGROUND
  In 1990, the Centers for Disease Control and Prevention recommended substituting dust-mist particulate respirators for simple isolation masks in acid-fast bacillus isolation rooms, reasoning that air leaks around the simple masks could result in a higher rate of purified protein derivative skin-test conversion. In 1993, a Centers for Disease Control and Prevention draft guideline proposed that high-efficiency particulate air filter respirators be used instead of dust-mist particulate respirators. Epidemiologic data were not available to assess the importance of these changes or their cost-effectiveness.
  
  
  METHODS
  The University of Virginia was affiliated with a tuberculosis hospital from 1979 until 1987. We surveyed physicians who had served as residents in internal medicine during this period regarding purified protein derivative skin-test history. duration of work at the tuberculosis sanatorium, and any history of unprotected exposures to patients with active pulmonary or laryngeal tuberculosis. Patients with active tuberculosis at the sanatorium were isolated in negative-pressure rooms with UV lights. Physicians wore simple isolation masks in these rooms.
  
  
  RESULTS
  Responses were received from 83 former resident physicians. Fifty-two physicians had worked on the tuberculosis wards for a total of 420 weeks, with no subsequent skin-test conversions (95% CI 0 to 1 conversion/8 physician-years).
  
  
  CONCLUSIONS
  These data document a low risk of occupational transmission of Mycobacterium tuberculosis to physicians who wear simple isolation masks in negative-pressure ventilation rooms with UV lights. This low rate predicts that the additional protective efficacy and cost-effectiveness of the more expensive high-efficiency particulate air filter respirators and the respiratory protection program will be low.
authors.affiliation: University of Virginia Health Sciences Center, Charlottesville.
authors.forename: J A
authors.initials: JA
authors.lastname: Jernigan
authors.forename: K A
authors.initials: KA
authors.lastname: Adal
authors.forename: A M
authors.initials: AM
authors.lastname: Anglim
authors.forename: K E
authors.initials: KE
authors.lastname: Byers
authors.forename: B M
authors.initials: BM
authors.lastname: Farr
mesh_terms: D006782:Hospitals, Special; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000517:prevention & control; D007396:Internship and Residency; D010356:Patient Isolation; D017410:Practice Guidelines as Topic; D011795:Surveys and Questionnaires; D014374:Tuberculin Test; D014376:Tuberculosis / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*; D014387:Tuberculosis, Laryngeal / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D012122:Ventilators, Mechanical; D014768:Virginia / Q000453:epidemiology