[Influence of the overall time of radiotherapy on local control for T2 cancer of the tongue].
Forty patients with T2 cancer of the tongue treated with external irradiation plus radium implants at Aichi Cancer Center were reviewed retrospectively to analyze the influence of overall treatment time on local control. One hundred percent (11/11) local control was achieved in patients irradiated within 35 days, in contrast to only 52% (13/25) local control in those irradiated over 35 days. This result indicates that prolonged overall time is associated with loss of local control. This prolongation is mainly due to the prolonged interval between external and interstitial irradiation. The interval was likely to be longer because of enhanced acute radiation mucositis, especially in patients administrated bleomycin during external irradiation. External irradiation should be followed by interstitial irradiation as soon as possible to keep overall time shorter.
Murao
T
T
Department of Radiation Oncology, Aichi Cancer Center Hospital.
Morita
K
K
D001761:Bleomycin / Q000008:administration & dosage; D001918:Brachytherapy; D017024:Chemotherapy, Adjuvant; D006801:Humans; D011879:Radiotherapy Dosage; D013997:Time Factors; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*
D001761:Bleomycin