title: The ciliary transportability of sputum is slow on the mucus-depleted bovine trachea.
abstract: Mucus retention in the lungs is a feature of several chest diseases. It is unclear to what extent suboptimal mucus transportability is responsible for the poor clearance of lung secretions. We described a new model, the mucus-depleted bovine trachea, for measurement of the ciliary transportability of respiratory mucus. Mucus depletion was demonstrated microscopically and functionally, and it was accomplished by simple physical means without impairing ciliary action. Control mucus from the tracheas of humans and animals was transported rapidly on this system. However, sputum from 54 patients with bronchiectasis was transported slowly, at a mean of 15% of the rate of control mucus. There was no correlation between sputum transportability and either purulence or the presence of Pseudomonas aeruginosa. This work suggests that there is a serious defect in the ciliary transportability of sputum that is unrelated to the presence of infection. The model should allow in vitro assessment of agents designed to aid mucociliary clearance.
authors.affiliation: Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, London, United Kingdom.
authors.forename: P J
authors.initials: PJ
authors.lastname: Wills
authors.forename: M J
authors.initials: MJ
authors.lastname: Garcia Suarez
authors.forename: A
authors.initials: A
authors.lastname: Rutman
authors.forename: R
authors.initials: R
authors.lastname: Wilson
authors.forename: P J
authors.initials: PJ
authors.lastname: Cole
mesh_terms: D000818:Animals; D001987:Bronchiectasis / Q000503:physiopathology*; D002417:Cattle; D006801:Humans; D009079:Mucociliary Clearance; D013183:Sputum / Q000502:physiology*; D013997:Time Factors; D014132:Trachea / Q000502:physiology*