Expression of the mouse ren-2 gene in the small intestine is regulated by food intake.
The existence of a local renin/angiotensin system in the intestine of mammals is speculative despite the known importance of angiotensin II for water and electrolyte homeostasis. We demonstrate the presence of ren-2 transcripts in the small intestine of DBA/2 mice. The marked expression of the ren-2 gene is blunted tissue-specifically by starvation, corroborating a local renin/angiotensin system in this organ.
Zhao
Y
Y
German Institute for High Blood Pressure Research, University of Heidelberg.
Peters
J
J
Ganten
D
D
Bader
M
M
D000818:Animals; D015152:Blotting, Northern; D004435:Eating / Q000502:physiology*; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012313:RNA / Q000378:metabolism; D013217:Starvation / Q000378:metabolism
D012313:RNA