Low-dose intrathecal clonidine releases tachykinins in rat spinal cord.
In decerebrate, spinalized, unanesthetized rats, 37 pmol (10 ng) intrathecally injected clonidine facilitated the flexor reflex. This effect was blocked by the specific tachykinin antagonists CP-96,345, which acts at the NK1 receptor, and Men 10207, which acts at the NK2 receptor. Thus, low-dose intrathecal clonidine releases the tachykinins substance P and neurokinin A in the spinal cord.
Luo
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Karolinska Institute, Department of Clinical Physiology, Huddinge, Sweden.
Wiesenfeld-Hallin
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Z
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D003655:Decerebrate State; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007278:Injections, Spinal; D015288:Neurokinin A / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism; D013373:Substance P / Q000378:metabolism*
D001713:Biphenyl Compounds; D006993:Hypnotics and Sedatives; D010446:Peptide Fragments; C063615:neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-; D013373:Substance P; D015288:Neurokinin A; D003000:Clonidine; C066892:CP 96345