title: Influence of prostaglandins on glucose transport in isolated rat uterus.
abstract: Glucose transport by uterine strips from ovariectomized estrogenized rats was explored. Sugar transport was significantly different from saccharose values (non-specific diffusion) only after 60 min of incubation. The addition of cytochalasin B demonstrated that we are measuring a specific mechanism for glucose transport. Insulin-enhanced sugar transport only at 0.5 or 0.25 U/ml prostaglandin E1 (PGE1), PGE2 and PGF2 alpha (10(-7) M) significantly improved glucose transport, but indomethacin (10(-6) M) failed in modifying this parameter in either control nor insulin-treated tissues. We did not observe an additive or synergistic action between PGE2 (10(-7) M) and insulin (used at maximal or submaximal concentration).
authors.affiliation: Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
authors.forename: E T
authors.initials: ET
authors.lastname: Gonzalez
authors.forename: A S
authors.initials: AS
authors.lastname: Jawerbaum
authors.forename: V
authors.initials: V
authors.lastname: Novaro
authors.forename: A L
authors.initials: AL
authors.lastname: Gimeno
authors.forename: M A
authors.initials: MA
authors.lastname: Gimeno
mesh_terms: D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001693:Biological Transport, Active / Q000187:drug effects; D003571:Cytochalasin B / Q000494:pharmacology; D004058:Diffusion; D015232:Dinoprostone / Q000494:pharmacology*; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D010052:Ovariectomy; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013395:Sucrose / Q000378:metabolism; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
chemical_list: D007328:Insulin; D011460:Prostaglandins F; D003571:Cytochalasin B; D004958:Estradiol; D013395:Sucrose; D000527:Alprostadil; D005947:Glucose; D015232:Dinoprostone; C100006:prostaglandin F1; D007213:Indomethacin