title: [A basic study for estimating the level of exposure to a nasal inhalant containing a stimulant].
abstract: Criminal cases involving stimulant abuse have increased since 1970 but have now leveled off. Some of the offenders claimed to have used the Vicks Inhaler containing a stimulant (1-methamphetamine) which is used for the treatment of nasal obstruction. The aim of this experiment was to measure the amount of 1-methamphetamine contained in the Vicks Inhaler by stimulating the human respiratory system. The results are as follows: 1) The data from the stimulation experiment showed that the inhalation level of 1-methamphetamine was estimated to be 320.4ng. From this value, the level of 1-methamphetamine absorbed per one respiration was calculated to be 21ng. 2) The data from quantitative and qualitative analysis by gas-chromatography showed that menthol interfered with the methamphetamine. 3) A qualitative test for the stimulant in urine was negative when the subject inhaled the Vicks Inhaler only once. However, this test turned positive when the subject inhaled it more than 17 times.
authors.affiliation: Criminal Investigation Laboratory, Metropolitan Police Department, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ando
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Fukumoto
authors.forename: H
authors.initials: H
authors.lastname: Okonogi
authors.forename: M
authors.initials: M
authors.lastname: Kadokura
mesh_terms: D002849:Chromatography, Gas; D006801:Humans; D008694:Methamphetamine / Q000032:analysis*; D008954:Models, Biological; D014663:Nasal Decongestants / Q000032:analysis*; D012119:Respiration; D019966:Substance-Related Disorders / Q000209:etiology
chemical_list: D014663:Nasal Decongestants; D008694:Methamphetamine