Primary central nervous system T-cell lymphoma with a predominant CD8 immunophenotype.
BACKGROUND
Primary T-cell lymphomas of the central nervous system are uncommon neoplasms.


METHODS
A case of a primary central nervous system T-cell lymphoma in a 66-year-old female who died 8 months after surgery is described. The biopsy specimen was evaluated by routine histology, immunohistochemistry, flow cytometry, and Southern blotting/DNA hybridization.


RESULTS
The neoplasm was composed of pleomorphic medium and large cells. Virtually all of the neoplastic cells reacted with antibodies to CD3, CD5, and CD8. Multiple rearranged bands were detected with the T-cell receptor beta-chain gene probe.


CONCLUSIONS
To the authors' knowledge, this is the first description of a primary central nervous system T-cell lymphoma composed of a predominant population of CD8-expressing T cells, and the first case confirmed by Southern blotting/DNA hybridization.
Novak
J A
JA
Department of Pathology and Laboratory Medicine, Mt. Sinai Medical Center, Cleveland, OH 44106, USA.
Katzin
W E
WE
D000368:Aged; D016827:CD8 Antigens / Q000032:analysis*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D016130:Immunophenotyping; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000235:genetics / Q000276:immunology* / Q000628:therapy
D016827:CD8 Antigens; D004273:DNA, Neoplasm