Non-synaptic diffusion neurotransmission: a novel concept for future migraine research.
The concept of non-synaptic diffusion neurotransmission (NDN) is reviewed. Evidence is presented that monoamine neurotransmission is largely by NDN. The role of NDN in pain and sleep is described and its relevance to migraine research is discussed.
Bach-y-Rita
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Department of Rehabilitation Medicine, University of Wisconsin Medical School, Madison.
D000818:Animals; D001679:Biogenic Amines / Q000502:physiology; D004058:Diffusion; D006801:Humans; D008881:Migraine Disorders / Q000503:physiopathology*; D010146:Pain / Q000503:physiopathology; D012106:Research; D012890:Sleep / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
D001679:Biogenic Amines