The effects of Tripterygium wilfordii extract on adjuvant arthritis in rats.
The effects of the extract of Tripterygium wilfordii. (TWE) on experimental adjuvant arthritis (AA) in the rat was studied. Lewis rats induced with AA were administered with TWE at 50 mg/kg/day for 10 weeks. The paw volume, its ratio to the body weight (paw ratio) and the radiologic changes in the feet of the rats with AA taking TWE were compared with those in the rats taking indomethacin (0.5 mg/kg/day) and no additional drugs. The rats taking TWE showed a smaller paw volume, a lower paw ratio and milder radiologic changes than the rats taking no drugs, however, the beneficial effects were weaker than those of indomethacin. We concluded that the beneficial effects of TWE on rats with AA was suggested. However, these results still need to be further confirmed by additional experiments.
Ren
L
L
Department of Clinical Immunology, Medical Institute of Bioregulation, Kyushu University, Oita, Japan.
Yasuda
M
M
Nonaka
S
S
Shiokawa
S
S
Wada
T
T
Nobunaga
M
M
D000818:Animals; D001169:Arthritis, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D011859:Radiography; D051381:Rats; D011917:Rats, Inbred Lew; D029757:Tripterygium
D004365:Drugs, Chinese Herbal