Developmental changes in hepatic IGF-2 and IGFBP-2 mRNA levels in intrauterine growth-retarded and control swine.
1. Significantly elevated levels of hepatic IGFBP-2 mRNA were detected in IUGR piglets at 90 days fetally and at birth (P < 0.05). 2. Developmentally, hepatic IGF-2 (P < 0.05) and IGFBP-2 (P < 0.01) mRNA levels were higher fetally and at birth than at 21 and 49 days of age. 3. This study provides new information concerning hepatic expression of IGF-2 and IGFBP-2 in developing swine.
Kampman
K A
KA
Department of Animal Science, Ohio State University, Columbus 43210.
Ramsay
T G
TG
White
M E
ME
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D018971:Insulin-Like Growth Factor Binding Protein 2; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics*; D013002:Somatomedins / Q000378:metabolism*; D013552:Swine
D001786:Blood Glucose; D002352:Carrier Proteins; D018971:Insulin-Like Growth Factor Binding Protein 2; D012333:RNA, Messenger; D013002:Somatomedins; D007335:Insulin-Like Growth Factor II; D004247:DNA