title: Quality of life of patients with severe chronic neutropenia receiving long-term treatment with granulocyte colony-stimulating factor.
abstract: OBJECTIVE
  To evaluate the impact of long-term granulocyte colony-stimulating factor (GCSF) treatment on quality of life of patients with congenital, cyclic, or idiopathic neutropenia. STUDY DESIGN, INTERVENTION, AND OUTCOME MEASURES: Twenty-one patients receiving daily subcutaneous GCSF responded to retrospective questions about disease-related symptoms and physical, psychological, and social functioning before and with GCSF therapy.
  
  
  RESULTS
  Statistically significant improvement occurred in energy, emotional reactions, social isolation, functional ability, life satisfaction, decreased hospital admissions, and school attendance.
  
  
  CONCLUSIONS
  GCSF greatly improves quality of life in patients with severe chronic neutropenia.
authors.affiliation: University of Washington, Seattle.
authors.forename: E A
authors.initials: EA
authors.lastname: Jones
authors.forename: A A
authors.initials: AA
authors.lastname: Bolyard
authors.forename: D C
authors.initials: DC
authors.lastname: Dale
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000628:therapy*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor