Expression of the endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells in experimental gingivitis in humans.
In inflammatory conditions, mediators such as interleukin-1 (IL-1) are released by resident tissue cells as well as by infiltrating inflammatory cells. IL-1 activates endothelial cells causing them to express an adhesion molecule called endothelial leukocyte adhesion molecule-1 (ELAM-1). IL-1 is produced by macrophages, but can also be produced by activated keratinocytes. Here we present data from a study of experimentally induced gingivitis, showing the expression of ELAM-1 on endothelial cells even in tissue with little or only minor signs of clinical or histological inflammation. These results indicate that ELAM-1 is found on endothelial cells of the gingiva early in the course of experimental gingivitis, before overt clinical or histological evidence of inflammation is apparent.
Nylander
K
K
Department of Oral Pathology, University of Umeå, Sweden.
Danielsen
B
B
Fejerskov
O
O
Dabelsteen
E
E
D002448:Cell Adhesion / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism / Q000473:pathology; D019040:E-Selectin; D004727:Endothelium / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D005881:Gingiva / Q000378:metabolism / Q000473:pathology; D005891:Gingivitis / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000235:genetics* / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D007375:Interleukin-1; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic