Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency.
Recombinant human insulin-like growth factor I (IGF-I), 40 micrograms/kg/body weight, was administered subcutaneously at 08.00 hours to six adult patients with growth hormone deficiency (GHD). The mean maximal IGF-I concentrations were found 2-6 hours after injection. Concentrations then gradually declined, though mean values were still above basal 24 hours after the injection. Only one patient maintained IGF-I levels above the lower normal range throughout 24 hours. There was a significant decrease in mean IGF-II concentrations when measured 4 and 24 hours after injection of IGF-I. The diurnal variations of insulin and IGF binding protein-1 were preserved. There were no side-effects, and blood glucose remained normal. These results show that in patients with low IGF-I levels resulting from GHD, it is necessary to administer IGF-I at intervals of less than 24 hours to obtain IGF-I levels that are within the normal range.
Thorén
M
M
Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.
Wivall-Helleryd
I L
IL
Hall
K
K
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002352:Carrier Proteins / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007279:Injections, Subcutaneous; D007328:Insulin / Q000097:blood; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D007335:Insulin-Like Growth Factor II / Q000032:analysis; D008297:Male; D011994:Recombinant Proteins
D001786:Blood Glucose; D002352:Carrier Proteins; D007328:Insulin; D018970:Insulin-Like Growth Factor Binding Protein 1; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D013006:Growth Hormone