title: In vivo and in vitro expression of canine distemper viral proteins in dogs and non-domestic carnivores.
abstract: The occurrence of the nucleo-, phospho-, matrix, fusion, and hemagglutinin proteins of the canine distemper virus (CDV) was investigated immunocytochemically in the brains of 3 dogs, 6 stone martens, 1 polecat, and 1 weasel. In addition, viral protein expression was studied in primary brain cell cultures of the 3 dogs after co-cultivation with Vero cells. Immunohistochemically, only minor differences, restricted to the H-4 epitope, were noted between the various species and CDV isolates. The data presented indicate that the mustelid virus is antigenically not distinct from the canine morbillivirus.
authors.affiliation: Institut für Veterinär-Pathologie, Justus-Univesität Giessen, Federal Republic of Germany.
authors.forename: S
authors.initials: S
authors.lastname: Alldinger
authors.forename: W
authors.initials: W
authors.lastname: Baumgärtner
authors.forename: P
authors.initials: P
authors.lastname: van Moll
authors.forename: C
authors.initials: C
authors.lastname: Orvell
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000382:microbiology*; D001921:Brain / Q000382:microbiology*; D002335:Carnivora / Q000382:microbiology*; D002525:Cerebellar Cortex / Q000382:microbiology; D004217:Distemper Virus, Canine / Q000254:growth & development / Q000302:isolation & purification*; D004285:Dogs; D000939:Epitopes; D007150:Immunohistochemistry; D009457:Neuroglia / Q000382:microbiology; D011689:Purkinje Cells / Q000382:microbiology; D014709:Vero Cells; D014764:Viral Proteins / Q000302:isolation & purification*; D014779:Virus Replication
chemical_list: D000939:Epitopes; D014764:Viral Proteins