Induction of mitotic- and meiotic-chromosome anomalies in mice and onion by distillery effluents.
A 2% dilution of distillery effluent not only inhibited mitosis but also induced a 10-fold increase in the frequency of chromosome abnormalities in onion root-tip cells. Polyploidy and disturbances in cytokinesis were also observed. A 1% dilution of the effluent, when administered orally at 0.5 ml per day per mouse, induced a 12-fold increase in chromosome abnormalities among bone marrow cells. The latter included both gross and individual types of damage. In the primary spermatocytes, the effluent induced a 14-fold increase in abnormalities among which X-Y univalents, polyploidy and translocation were most common.
Chaurasia
O P
OP
Department of Zoology, T. M. Bhagalpur University, India.
D000490:Allium; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D008297:Male; D008540:Meiosis / Q000187:drug effects* / Q000235:genetics; D051379:Mice; D008938:Mitosis / Q000187:drug effects* / Q000235:genetics; D013090:Spermatocytes / Q000166:cytology / Q000187:drug effects; D014877:Water Pollution, Chemical / Q000009:adverse effects*