A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL gene.
Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed-lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene.
Jani Sait
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Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263.
Raimondi
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Look
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Gill
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Thirman
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Diaz
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Shows
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D015139:Blotting, Southern; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D008297:Male; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D015183:Restriction Mapping; D014178:Translocation, Genetic