Role of endogenous cyclo(His-Pro) in cold-induced hypothermia in the desert rat (Mastomys natalensis).
Central administration of exogenous cyclo(His-Pro) (CHP) is known to produce hypothermia in rodents. In the present study, we examined the role of endogenous CHP in cold-induced hypothermia in the desert rat, Mastomys natalensis. The results of these studies show that a rise in hypothalamic CHP content accompanied a decrease in rectal temperature during cold exposure. Immunoneutralization of endogenous CHP resulted in a significant decline in cold-induced hypothermia. In addition, central administration of cyclo(Ala-Gly), a structural analogue of CHP, also led to a decrease in cold-induced hypothermia. The results of these studies show that changes in endogenous CHP levels may affect body temperature regulation.
Shukla
R
R
Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
Rahmani
N H
NH
Mizuma
H
H
Srimal
R C
RC
Prasad
C
C
D000704:Analysis of Variance; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D003080:Cold Temperature; D003889:Desert Climate; D054659:Diketopiperazines; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D007036:Hypothermia, Induced; D007276:Injections, Intraventricular; D008297:Male; D009115:Muridae / Q000502:physiology*; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000032:analysis / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D010879:Piperazines / Q000008:administration & dosage / Q000032:analysis / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity
D000906:Antibodies; D054659:Diketopiperazines; D010456:Peptides, Cyclic; D010879:Piperazines; C010939:2,5-dioxopiperazine; C092789:cyclo(alanyl-glycyl); C015924:histidyl-proline diketopiperazine