[Antimutagenesis as a genetic process].
The concept that antimutagenesis is a normal genetic process whose function is to ensure integrity and stability of hereditary structures has been formulated and substantiated. The phenomenon of antimutagenesis is realized by the antimutagenic cell system, forming the first level of DNA protection from the mutagenic influences of endogenous and exogenous agents. Repair systems constitute the second protective level. The common mechanism of the protective action of exogenous antimutagens is that they act through the antimutagenic system components and/or the repair systems. The resistance of organisms to external factors and damaged to their cell systems is determined by a set of components and the intensity of antimutagenic and repair functioning.
Goncharova
R I
RI
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects / Q000235:genetics; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D016296:Mutagenesis / Q000187:drug effects* / Q000235:genetics*; D009153:Mutagens / Q000494:pharmacology
D016587:Antimutagenic Agents; D009153:Mutagens; D004247:DNA