Ascorbic acid stimulation of gonadotropin release from hamster anterior pituitary gland is not mediated through cyclic nucleotide system.
Ascorbic acid (AA) can transiently stimulate LH and FSH release from superfused male hamster anterior pituitary glands. The effective concentration is 1 mM or higher. Since 8-Br-cAMP or 8-Br-cGMP can not mimic the AA stimulation pattern, the action mechanism is not mediated through cyclic nucleotide system.
Wun
W S
WS
Department of Reproductive Medicine and Biology, University of Texas Medical School at Houston 77025.
Berkowitz
A S
AS
Preslock
J P
JP
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D006224:Cricetinae; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*
D006062:Gonadotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D006152:Cyclic GMP; D001205:Ascorbic Acid