title: Cortical reactivity in REM sleep with tonic mentalis EMG activity induced by clomipramine: an evaluation by slow vertex response.
abstract: Slow vertex response (SVR) to sound stimuli was used as an index to assess whether cortical reactivity in REM sleep with tonic mentalis EMG activity (stage 1-REM) corresponds to that in REM sleep or rather to that in stage 1 of NREM sleep. In 11 young adult subjects 3 night polygraphic records were made after administration of 25 or 50 mg of clomipramine or non-active placebo. Stage 1-REM was observed in the drug night in 8 of the 11 subjects. N1-P2 and P2-N2 amplitudes of SVR were markedly smaller in stage 1-REM than in stage 1, but were virtually of the same height in stage 1-REM and in stage REM. This indicates that cortical reactivity in stage 1-REM closely resembles the counterpart in stage REM. This finding corresponds well with the frequent emergence of vivid dreams in stage 1-REM, indicating that stage 1-REM observed in the present subjects probably represents REM sleep without muscle atonia.
authors.affiliation: Department of Neuropsychiatry, Akita University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Niiyama
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Hishikawa
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D002997:Clomipramine / Q000494:pharmacology*; D004576:Electromyography; D006801:Humans; D008297:Male; D009132:Muscles / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects*
chemical_list: D002997:Clomipramine