Mathematical modelling of the enteric nervous network. 4. Analysis of adrenergic transmission.
Based on the model of the adrenergic neurone proposed earlier, the dynamics of nerve-pulse transmission after treatment with inhibitors of neuronal uptake and catechol-O-methyltransferase, alpha 1-adrenoceptor antagonists, changes in the concentration of Ca2+ ions in the external medium, the action of tetrodotoxin (TTX) and repetitive stimulation, are analysed. The results of numerical simulation show that: the addition of drugs that inhibit neuronal uptake and catechol-O-methyltransferase cause the augmentation of noradrenaline action on post-synaptic structures and an increase in the amplitude of the generated inhibitory post-synaptic potential (IPSP); treatment with adrenergic antagonists reduces the amplitude of IPSP; decrease in the concentration of extracellular Ca2+ ions and application of TTX abolish the post-synaptic response. All these effects are shown to be dose-dependent. The repetitive stimulation of the neurone reproduces the effects of accumulation and potentiation. Possible applications of the results obtained are discussed.
Miftakhov
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Gastrointestinal Science Research Unit, Royal London Hospital Medical College, University of London, UK.
Wingate
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DL
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D065098:Catechol O-Methyltransferase Inhibitors; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D017615:Enteric Nervous System / Q000502:physiology*; D008959:Models, Neurological; D009415:Nerve Net / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D065098:Catechol O-Methyltransferase Inhibitors; D011941:Receptors, Adrenergic; D013779:Tetrodotoxin; D002118:Calcium; D009638:Norepinephrine