[Effect of anapriline on the pharmacodynamic effects of strophanthin in experiments on isolated myocardial preparations and under conditions of simulation of cardiac insufficiency].
The action of the beta-adrenoblocker anaprilline on the pharmacodynamic effects of strophanthin was examined in in vivo experiments during simulated rat heart failure and on isolated frog atrial specimens. Anaprilline was demonstrated to substantially reduce the toxicity of the cardiac glycoside during decompensated circulation, without producing noticeable effects on cardiac inotropic function. The experiments on isolated myocardial specimens revealed a slight decrease in the cardiostimulant action of the cardiac glycoside and a reduction in its development rate.
Lemkina
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D000818:Animals; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013328:Strophanthins / Q000494:pharmacology*
D013328:Strophanthins; D011433:Propranolol