title: Comparative study of SCE induction and cytostatic effects by homo-azasteroidal esters of N,N-bis(2-chloroethyl)aminobenzoic acid in human lymphocytes.
abstract: The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biological basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to induce sister-chromatid exchanges (SCEs) and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumor activity of these compounds was observed.
authors.affiliation: Department of General Biology and Genetics, Medical School, Aristotle University, Thessaloniki, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Mourelatos
authors.forename: E
authors.initials: E
authors.lastname: Mylonaki
authors.forename: A
authors.initials: A
authors.lastname: Papageorgiou
authors.forename: L
authors.initials: L
authors.lastname: Boutis
authors.forename: A
authors.initials: A
authors.lastname: Paradelis
authors.forename: A
authors.initials: A
authors.lastname: Anastasiou
authors.forename: P
authors.initials: P
authors.lastname: Catsoulacos
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D001378:Azasteroids / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D009153:Mutagens / Q000737:chemistry / Q000494:pharmacology*; D009588:Nitrogen Mustard Compounds / Q000737:chemistry / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D001378:Azasteroids; D009153:Mutagens; D009588:Nitrogen Mustard Compounds