[Maternal and cord blood thyroid hormones in Graves' disease and fetal states].
Serum concentrations of thyroid hormones (T3, T4, fT3 and fT4), TSH and TRAb in 14 mothers with Graves' disease at 1-4 weeks before delivery were comparably studied with cord blood hormone levels and various fetal states. Twelve mothers were on anti-thyroid drugs and 2 were drug-free, with 8 being euthyroid and 6 being hyperthyroid. Serum concentrations of T3, T4 and fT3 in cord blood were all the same regardless of maternal thyroidal function. Though cord blood TRAb levels correlated with maternal levels, cord fT4 levels were low in those who given antithyroid drugs. TSH levels in cord blood were low in Cesarean section delivery and babies with low birth weight. Birth weight and gestational weeks were both inversely correlated with maternal T4, fT4, fT3 and TRAb concentrations. Thus, maternal hormone levels at late stage of pregnancy in Graves' disease could be useful indices for perinatal risk.
Koike
S
S
Radioassay Center, Tokyo Women's Medical College.
Aoyama
A
A
Yamaguchi
N
N
Natori
Y
Y
Suzuki
T
T
Itou
M
M
Kusakabe
K
K
Demura
R
R
D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D001724:Birth Weight; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006111:Graves Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications; D012306:Risk; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood
D013956:Antithyroid Agents; D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D013963:Thyroid Hormones; D013972:Thyrotropin