title: Selective neurokinin NK1 and NK2 receptor agonists infused in the substantia nigra of the rat increase vacuous chewing.
abstract: Bilateral intranigral infusion of selective neurokinin NK1 and NK2 receptor agonists were made in freely moving rats followed by measurements of vacuous chewing frequencies for 30 min post-infusion. The NK1 receptor agonist, [Pro9] substance P, induced an immediate dose-related elevation of non-object directed vacuous chewing movements. There was a linear dose-response relation in the 0.5-5 nmol dose range. In experiments with the NK2 receptor agonist, [Lys5,MeLeu9,Nle10]neurokinin A-(4-10), the highest dose, 4.8 nmol, caused a less intensive but longer lasting increase of the vacuous chewing movement frequency. These findings may imply a role for neurokinins in the regulation of oral movements.
authors.affiliation: Department of Psychiatry at Ulleråker, Uppsala University, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Liminga
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008409:Mastication / Q000187:drug effects*; D015288:Neurokinin A / Q000031:analogs & derivatives / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D013378:Substantia Nigra / Q000187:drug effects*
chemical_list: D010446:Peptide Fragments; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter; C080627:neurokinin A (4-10), Lys(5)-Tyr(I2)(7)-MeLeu(9)-Nle(10)-; C067285:substance P, Pro(9)-; D013373:Substance P; D015288:Neurokinin A; C056408:neurokinin A(4-10)