Sister-chromatid exchange: second report of the Gene-Tox Program.
This paper reviews the ability of a number of chemicals to induce sister-chromatid exchanges (SCEs). The SCE data for animal cells in vivo and in vitro, and human cells in vitro are presented in 6 tables according to their relative effectiveness. A seventh table summarizes what is known about the effects of specific chemicals on SCEs for humans exposed in vivo. The data support the concept that SCEs provide a useful indication of exposure, although the mechanism and biological significance of SCE formation still remain to be elucidated.
Tucker
J D
JD
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94551.
Auletta
A
A
Cimino
M C
MC
Dearfield
K L
KL
Jacobson-Kram
D
D
Tice
R R
RR
Carrano
A V
AV
D002478:Cells, Cultured; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D012854:Sister Chromatid Exchange
D009153:Mutagens