Gene clusters encoding the cytotoxic necrotizing factor type 1, Prs-fimbriae and alpha-hemolysin form the pathogenicity island II of the uropathogenic Escherichia coli strain J96.
The uropathogenic Escherichia coli strain J96 (04:K6) is able to produce four adherence factors [P-fimbriae (pap and prs), F1C-fimbriae (foc) and Type 1-fimbriae (fim)], two alpha-hemolysins (hlyI and II) and the cytotoxic necrotizing factor type 1 (cnf1). Using phenotypic test systems and genotypic analysis, it has been shown that the mutant strain J96-M1 has lost the hlyII, prs and cnf1 genes. The three virulence associated determinants are linked on one particular region on the chromosome, which is termed 'pathogenicity island II' (Pai II).
Blum
G
G
Institut für Molekulare Infektionsbiologie, Würzburg, Germany.
Falbo
V
V
Caprioli
A
A
Hacker
J
J
D018829:Adhesins, Bacterial / Q000235:genetics*; D001427:Bacterial Toxins / Q000235:genetics*; D002874:Chromosome Mapping; D003603:Cytotoxins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins / Q000235:genetics*; D005810:Multigene Family; D009154:Mutation
D018829:Adhesins, Bacterial; D001427:Bacterial Toxins; D003603:Cytotoxins; D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; C060296:cytotoxic necrotizing factor type 1