title: Recurrence of primary biliary cirrhosis after liver transplantation following FK506-based immunosuppression.
abstract: We report two cases of recurrence of primary biliary cirrhosis (PBC) in the transplanted liver whilst maintained on a FK506-based immunosuppressive regime, the first to be described. One patient experienced symptoms in association with the development of cholestasis. In both there was a persistence of serological markers of PBC and liver histology revealed florid bile duct destruction and a granulomatous reaction.
authors.affiliation: Institute of Liver Studies, King's College Hospital and School of Medicine and Dentistry, London, United Kingdom.
authors.forename: P Y
authors.initials: PY
authors.lastname: Wong
authors.forename: B
authors.initials: B
authors.lastname: Portmann
authors.forename: J G
authors.initials: JG
authors.lastname: O'Grady
authors.forename: J J
authors.initials: JJ
authors.lastname: Devlin
authors.forename: J E
authors.initials: JE
authors.lastname: Hegarty
authors.forename: K C
authors.initials: KC
authors.lastname: Tan
authors.forename: R
authors.initials: R
authors.lastname: Williams
mesh_terms: D000328:Adult; D002779:Cholestasis / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000209:etiology* / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D016559:Tacrolimus