title: Two phenotypically distinct B lymphocytes (IgMhighIgDlow and IgMlowIgDhigh) in chronic gastric ulcer in the rat.
abstract: We determined the kinetics and phenotypes of infiltrating B cells in gastric ulcer in the rat induced by gastric injection of acetic acid (day 0). Few B cells were found in the lesion in the early stages of ulceration. On day 40, two kinds of B cells with phenotypes of IgMhighIgDlowOX33 (CD45)+OX19 (CD5)- and IgMlowIgDhighOX33 (CD45)+OX19 (CD5)- were scattered in the granulation tissue of open ulcers, but not in the healed scar tissue. On day 180, those two kinds of B cells formed primary follicles in the granulation tissue of open ulcers, but were absent from the healed scar tissue. The IgMhighIgDlowOX33 (CD45)+OX19 (CD5)- B cell was considered to be identical to the marginal zone B cell of rat spleen. This phenotype of B cell might be associated with inflammatory process in chronic gastric ulcer.
authors.affiliation: Second Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ohmiya
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Ohbayashi
authors.forename: T
authors.initials: T
authors.lastname: Arisawa
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: J
authors.initials: J
authors.lastname: Asai
mesh_terms: D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002908:Chronic Disease; D005455:Fluorescent Antibody Technique; D007072:Immunoglobulin D / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D016130:Immunophenotyping; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D013276:Stomach Ulcer / Q000139:chemically induced / Q000276:immunology*
chemical_list: D000085:Acetates; D007072:Immunoglobulin D; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell; D019342:Acetic Acid