title: Nail fold capillaroscopy and echocardiography in mild-to-moderate hypertension treated with cilazapril plus hydrochlorothiazide: first results.
abstract: Essential hypertension is characterized by parallel and potentially reversible vascular and cardiac adaptations. In our study, capillaroscopy, echocardiography, and 24-h ambulatory blood pressure profiles were performed in 17 patients (aged 33-63 years; mean, 52 years) with mild-to-moderate hypertension. We measured morphological and hemodynamic parameters of capillary microcirculation as well as morphological echocardiographic parameters at baseline and after 6 weeks' treatment with 5 mg of cilazapril plus 12.5 mg of hydrochlorothiazide. Digital capillary blood flow measurements were assessed by nail fold video capillaroscopy. After 6 weeks of treatment with cilazapril plus hydrochlorothiazide, mean diastolic 24-h ambulatory blood pressure decreased from 98 +/- 6 to 85 +/- 7 mm Hg. Capillary blood cell velocity was 0.6 +/- 0.4 mm/s at baseline and increased to 0.6 +/- 0.4 mm/s. There were no significant changes in morphological capillaroscopic and echocardiographic parameters. In conclusion, we observed a trend toward higher capillary blood cell velocity as early as after 6 weeks of treatment with cilazapril plus hydrochlorothiazide in mild-to-moderate hypertension.
authors.affiliation: Medical Outpatient Clinic, University Hospital, Basel, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Weinbacher
authors.forename: B
authors.initials: B
authors.lastname: Martina
authors.forename: P
authors.initials: P
authors.lastname: Gasser
authors.forename: M
authors.initials: M
authors.lastname: Köhler
authors.forename: T
authors.initials: T
authors.lastname: Bart
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D002196:Capillaries / Q000187:drug effects / Q000502:physiology; D002200:Capillary Resistance; D017315:Cilazapril / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004452:Echocardiography; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008853:Microscopy / Q000379:methods; D008875:Middle Aged; D009262:Nails / Q000098:blood supply; D014741:Video Recording
chemical_list: D006852:Hydrochlorothiazide; D017315:Cilazapril