Synthesis and pharmacological study of some derivatives of pyrazolo[4,3-c]pyrido[3,2-c]-1,2-thiazine-5,5-dioxide, a novel heterocyclic ring system.
Starting from pyridothiazines 1 and N-methyl(phenyl)hydrazines isomeric derivatives 2 and 3 of the pyrazolo[4,3-c]pyrido[3,2-e]-1,2-thiazine, a new heterocyclic ring system, have been obtained. The structure of the synthesized compounds was confirmed by spectroscopic and elemental analyses. The results of the preliminary pharmacological study of CNS effects caused by compounds 2 are reported.
Malinka
W
W
Department of Drug Chemistry, Wroclaw University of Medicine, Poland.
Sieklucka-Dziuba
M
M
Rajtar-Cynke
G
G
Gasior
M
M
Kleinrok
Z
Z
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000700:Analgesics; D013843:Thiazines