New metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. VI. Structure determination of non-halogenated metabolites structurally related to mycorrhizin A.
The structure determination of four new biologically active non-halogenated metabolites isolated from submerged cultures of the ascomycete Lachnum papyraceum is described. The compounds are structurally related to the antibiotic mycorrhizin A: (l'Z)-Dechloromycorrhizin A (12), a stereoisomer of dechloromycorrhizin A (5) previously isolated from the same fungus, as well as papyracon A (13), papyracon B (14) and papyracon C (15) containing an exocyclic double bond. The amounts of the latter three increased significantly when CaBr2 was added to the culture medium. The structures were determined by spectroscopic methods.
Stadler
M
M
University of Kaiserslautern, Department of Biotechnology, Germany.
Anke
H
H
Shan
R
R
Sterner
O
O
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000969:Antinematodal Agents / Q000737:chemistry* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology; D006219:Halogens / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D003374:Coumarins; D006219:Halogens; C092870:mycorrhizin A