Interleukin-1-mediated acute lung injury and tolerance to oxidative injury.
Interleukin-1 (IL-1) is a highly potent molecule that has a myriad of effects in biologic systems. This brief review describes some of our findings on the effects of IL-1 in biologic systems. On the one hand, IL-1 treatment caused a neutrophil-dependent acute edematous lung injury that resembled changes in the lungs of patients with the acute respiratory distress syndrome (ARDS). On the other hand, IL-1 pretreatment conferred a tolerance to lung oxidative lung injury and ischemia-reperfusion insults--again conditions manifest in sick patients. The potential mechanisms responsible for these seemingly paradoxical influences of IL-1 are described and related to possible strategies for the treatment of patients with ARDS, ischemia-reperfusion disorders, and other oxidant-mediated conditions.
Repine
J E
JE
Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver.
D000208:Acute Disease; D000818:Animals; D004361:Drug Tolerance; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology / Q000502:physiology*; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000503:physiopathology; D015425:Myocardial Reperfusion; D017382:Reactive Oxygen Species / Q000494:pharmacology
D007375:Interleukin-1; D017382:Reactive Oxygen Species