Rearrangement of band q13 on both chromosomes 12 in a periosteal chondroma.
Cytogenetic analysis of a recurrent periosteal chondroma revealed nonreciprocal translocations of both chromosomal segments 12q13-->qter, from one chromosome 12 to 7q32 and from the homologous chromosome 12 to 16q22. The remaining parts of the two chromosomes 12 formed a dicentric chromosome. This is the second reported chondroma with a 12q13-15 rearrangement, and changes of this chromosome region consequently seem to be nonrandom occurrences in chondromas.
Mandahl
N
N
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Willén
H
H
Rydholm
A
A
Heim
S
S
Mitelman
F
F
D000328:Adult; D002812:Chondroma / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000648:ultrastructure*; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D002897:Chromosomes, Human, Pair 7 / Q000648:ultrastructure; D005266:Femoral Neoplasms / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D014178:Translocation, Genetic