A nitro analogue of staurosporine and other minor metabolites produced by a Streptomyces longisporoflavus strain.
From the staurosporine-producing strain Streptomyces longisporoflavus R-19 various minor metabolites were isolated: They include a new compound with a nitro function in C-4' and other metabolites related to staurosporine. The new structures were elucidated by spectroscopic methods, mainly 1H NMR and 13C NMR and by comparison with TAN-1030A. The new compounds inhibited protein kinase C with IC50 values in the nanomolar range.
Cai
Y
Y
Pharmaceutical Research Department, CIBA-GEIGY Ltd, Basle, Switzerland.
Fredenhagen
A
A
Hug
P
P
Peter
H H
HH
D000470:Alkaloids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry / Q000302:isolation & purification; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D016339:Spectrometry, Mass, Fast Atom Bombardment; D019311:Staurosporine; D013302:Streptomyces / Q000378:metabolism*
D000470:Alkaloids; D017672:Nitrogen Compounds; D011493:Protein Kinase C; D019311:Staurosporine