A three step protocol for the treatment of idiopathic subfertility.
650 couples with idiopathic subfertility (mean duration: 5.7 year, range 2-21 years) were treated during 2870 cycles by three assisted conception methods (each involving mild ovarian stimulation): I timed intercourse (TI), II intrauterine insemination (IUI). III in vitro fertilization/embryo transfer (IVF/ET). Treatment started with TI in most cases and then changed to IUI after three to six cycles. Couples who failed to conceive were treated after another 3-9 cycles by IVF/ET. An overall cumulative pregnancy rate of 80.2% was reached after 18 treatment months. The pregnancy rates per treatment cycle were: TI 5.3%, IUI 6.9%, IVF/ET 15.8% (per oocyte retrieval).
Berg
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I. Frauenklinik der Universität München, Germany.
Seifert-Klauss
V
V
Lauritzen
C
C
Teschner
A
A
Brucker
C
C
D002985:Clinical Protocols; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000628:therapy*; D007317:Insemination, Artificial, Homologous; D011247:Pregnancy; D012099:Reproductive Techniques; D016896:Treatment Outcome