title: A metabolite of substance P, SP7-11 is involved in the pathogenesis of inflammatory joint disease.
abstract: The possibility that neuropeptides, in particular members of the tachykinin family are involved in inflammatory joint disease is widely disputed. Both clinical and experimental observations indicate that the tachykinin substance P (SP) may be involved in the pathogenesis of arthritis. We have studied the effects of tachykinins and the metabolites of SP on chondrocyte function. We have shown that the C-terminal pentapeptide sequence; H-Phe-Phe-Gly-Leu-Met-NH2 is biologically active in bovine chondrocyte cultures. The production of SP7-11 is limited by hydrolysis of the intact peptide by neutral endopeptidase (E.C. 3.4.24.11). The regulation of this enzyme would modulate the activity of substance P on articular cartilage chondrocytes.
authors.affiliation: Department of Medicine, Royal Adelaide Hospital, South Australia.
authors.forename: D A
authors.initials: DA
authors.lastname: Halliday
authors.forename: J D
authors.initials: JD
authors.lastname: McNeil
authors.forename: R
authors.initials: R
authors.lastname: Scicchitano
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002356:Cartilage / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007592:Joint Diseases / Q000503:physiopathology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology / Q000502:physiology*; D013373:Substance P / Q000494:pharmacology / Q000502:physiology*; D015320:Tachykinins / Q000502:physiology*
chemical_list: D010446:Peptide Fragments; D015320:Tachykinins; D013373:Substance P; C061335:substance P (7-11)