Isotypic analysis of Plasmodium falciparum-specific antibodies and their relation to protection in Madagascar.
We previously reported that antibodies to the central repeat (DDEHVEEPTVA) of Pf155/RESA, a major Plasmodium falciparum antigen, were negatively related to antimalarial protection. We measured levels of isotype antibodies to this epitope and to P. falciparum in 76 Madagascan subjects. Immunoglobulin G (IgG) and isotype antibodies specific for P. falciparum had similar levels in individuals who were considered protected and those who were not (as determined during a longitudinal follow-up). The levels of IgG1 antibodies to (DDEHVEEPTVA)3 were higher in nonprotected subjects. The levels of total IgG and of other isotype antibodies had a similar tendency to be higher in nonprotected than in protected individuals.
Dubois
B
B
Unité 13, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Deloron
P
P
Astagneau
P
P
Chougnet
C
C
Lepers
J P
JP
D000595:Amino Acid Sequence; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D000918:Antibody Specificity; D000939:Epitopes; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000276:immunology; D008270:Madagascar; D016778:Malaria, Falciparum / Q000276:immunology*; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*
D000913:Antibodies, Protozoan; D000939:Epitopes; D007132:Immunoglobulin Isotypes; D010455:Peptides