Effect of beraprost sodium on changes in action potentials during hypoxia as compared with propranolol, diltiazem and glibenclamide in guinea-pig ventricular muscle.
The inhibitory effect of beraprost on the transmembrane action potentials was compared with other cardioprotective drugs during hypoxia in guinea-pig isolated right ventricular muscle. Glibenclamide, like beraprost, inhibited the decrease of the action potential duration, but propanolol and diltiazem did not affect this decrease during hypoxia. In beraprost-treated preparations, the decrease of the myocardial K+ content during hypoxia was inhibited. Furthermore, beraprost prevented the action potential shortening during metabolic inhibition by 2,4-dinitrophenol. It is suggested that beraprost may inhibit the hypoxia- and 2,4-dinitrophenol-induced shortening of the action potential duration by preserving the muscular ATP level. Accordingly, beraprost may have beneficial effects both during hypoxia and metabolic inhibition.
Ueno
Y
Y
Toray Industries, Inc., Basic Research Laboratories, Kanagawa, Japan.
Shigenobu
K
K
Nishio
S
S
D019297:2,4-Dinitrophenol; D000200:Action Potentials / Q000187:drug effects; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004110:Diltiazem / Q000494:pharmacology; D004140:Dinitrophenols / Q000037:antagonists & inhibitors; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000187:drug effects*; D000860:Hypoxia / Q000188:drug therapy; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D016276:Ventricular Function
D004140:Dinitrophenols; C048081:beraprost; D000255:Adenosine Triphosphate; D011433:Propranolol; D011464:Epoprostenol; D004110:Diltiazem; D019297:2,4-Dinitrophenol; D011188:Potassium; D005905:Glyburide