title: Vitronectin and its receptors.
abstract: The extracellular matrix protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3. Cell interaction with vitronectin may induce spreading and migration and have an effect on cell growth and differentiation in specific processes, such as tumor growth and metastasis, wound healing, bone resorption and viral infection.
authors.affiliation: Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037.
authors.forename: B
authors.initials: B
authors.lastname: Felding-Habermann
authors.forename: D A
authors.initials: DA
authors.lastname: Cheresh
mesh_terms: D000818:Animals; D017209:Apoptosis; D001862:Bone Resorption; D002448:Cell Adhesion; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D016024:Receptors, Cytoadhesin / Q000502:physiology*; D019030:Receptors, Vitronectin; D015398:Signal Transduction; D019096:Vitronectin
chemical_list: D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D016023:Integrins; D016024:Receptors, Cytoadhesin; D019030:Receptors, Vitronectin; D019096:Vitronectin