TFIIIA: nine fingers--three hands?
Over ten years ago transcription factor IIIA (TFIIIA) was identified as the only protein that binds specifically to both RNA and DNA. Although many details of its biochemical and biological activities have since been discovered, the complicated, multifunctional nature of this protein is still not fully understood. This article reviews interesting and perhaps important developments in the TFIIIA story.
Pieler
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Max-Planck-Institut für Molekulare Genetik, Berlin, Germany.
Theunissen
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O
D000595:Amino Acid Sequence; D000818:Animals; D004247:DNA / Q000378:metabolism; D008969:Molecular Sequence Data; D012313:RNA / Q000378:metabolism; D012341:RNA, Ribosomal, 5S / Q000235:genetics; D035582:Transcription Factor TFIIIA; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D014982:Xenopus laevis; D016335:Zinc Fingers / Q000235:genetics
D012341:RNA, Ribosomal, 5S; D035582:Transcription Factor TFIIIA; D014157:Transcription Factors; D012313:RNA; D004247:DNA