[Changes in cervix cytology in women with liver transplants treated with immunosuppressive therapy].
During the time 1989 to 1992 we collected PAP smears of 58 women before and several times after a liver transplantation. Five of the patients (= 8.6%) showed a suspicious PAP smear, although pre-transplantation they had a normal cervical cytology. Histological one woman even had a higher grade dysplasia. 30 women received FK 506 after the liver transplantation, 28 patients Cyclosporin A as long-term medication. Likewise kidney and liver transplanted women have a higher risk to be affected by a cervical neoplasia. A acceleration of malignant growth seems to be likely. The influence on the cervical cells of both immunosuppressive drugs Cyclosporin A (Sandimmun) and FK 506 seem to be similar. It should be recommended to perform a close-meshed cervical cytology control when following -up the female liver transplant recipients.
David
M
M
Geburtshilflich-gynäkologische Abteilung, Universitätsklinikum Rudolf Virchow, Freien Universität Berlin.
Sohl
S
S
Krause
H
H
Farkic
M
M
Neuhaus
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000187:drug effects / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016031:Liver Transplantation / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D065006:Papanicolaou Test; D011183:Postoperative Complications / Q000139:chemically induced / Q000473:pathology; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000473:pathology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000473:pathology; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use; D002578:Uterine Cervical Dysplasia / Q000139:chemically induced* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014626:Vaginal Smears
D016572:Cyclosporine; D016559:Tacrolimus