title: Time course of haemodynamic changes after maximal exercise.
abstract: The haemodynamic changes during 4 h following maximal upright bicycle exercise were evaluated in six normals in a randomized controlled crossover design. Total peripheral resistance was reduced to 2 h (-6.7 mmHg min l-1, P < 0.05); exercising and non-exercising vascular beds were vasodilated for 2 h (-24.1 and -23.8 mmHg min ml-1 100 ml-1 tissue, respectively, P < 0.05), associated with reductions in systolic (-5.8 mmHg, P < 0.05) and diastolic pressure (-8.3 mmHg, P < 0.05). Rise in cardiac index for 1 h (+0.51 min-1 m-2, P < 0.05) was accounted for by an elevated heart rate (+14.4 beats min-1, P < 0.01) as stroke volume was unchanged. Body temperature was elevated until 40 min (+0.20 degrees C, P < 0.05). The return of all haemodynamic variables to control by 3 h suggests a 3 h limit for a hypotensive effect of exercise. Rise in body temperature is not the only factor responsible for the hypotension.
authors.affiliation: Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.
authors.forename: J E
authors.initials: JE
authors.lastname: Isea
authors.forename: M
authors.initials: M
authors.lastname: Piepoli
authors.forename: S
authors.initials: S
authors.lastname: Adamopoulos
authors.forename: G
authors.initials: G
authors.lastname: Pannarale
authors.forename: P
authors.initials: P
authors.lastname: Sleight
authors.forename: A J
authors.initials: AJ
authors.lastname: Coats
mesh_terms: D000328:Adult; D001831:Body Temperature; D018592:Cross-Over Studies; D015444:Exercise; D006439:Hemodynamics; D006801:Humans; D008297:Male