Behavioral effects of the reversible dopamine antagonist flupenthixol are not potentiated by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in the preweanling rat.
In the preweanling rat, the irreversible dopamine (DA) receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) does not diminish behaviors induced by the nonselective DA agonist R(-)-propylnorapomorphine (NPA). To determine whether EEDQ was simply inactivating an insufficient percentage of DA receptor antagonist) and/or EEDQ. When given alone, flupenthixol (0.04, 0.1, and 0.4 mg/kg, intraperitoneally [IP]) produced a dose-dependent decrease in the behavioral effects induced by 1.0 mg/kg NPA. Unexpectedly, EEDQ (7.5 mg/kg, IP) did not potentiate flupenthixol's actions. This suggests that EEDQ's inability to block the NPA-induced behaviors of preweanling rats was not the result of an insufficient percentage of DA receptors being inactivated.
McDougall
S A
SA
Department of Psychology, California State University, San Bernardino 92407.
Bolanos
C A
CA
D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005475:Flupenthixol / Q000494:pharmacology*; D006120:Grooming / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013239:Stereotyped Behavior / Q000187:drug effects
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D011804:Quinolines; C009074:N-n-propylnorapomorphine; C000470:EEDQ; D005475:Flupenthixol; D001058:Apomorphine