title: Revisiting the role of mutagenesis in the induction of lung cancers in rats by diesel emissions.
abstract: Recent studies have reported the induction of lung tumors in rats chronically exposed to levels of diesel-engine emissions which interfered with lung clearance. The present analysis suggests that the mutagenic substances (e.g. dinitropyrenes, polycyclic aromatic hydrocarbons) present in diesel particulates are not major contributors to rat-lung carcinogenesis. The cancers presumably result from lung "overloading" and the ensuing inflammatory response. In the absence of additional data, this putative mechanism of diesel-caused cancer cannot be extrapolated to other species at risk from exposure to diesel emissions.
authors.affiliation: Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261.
authors.forename: H S
authors.initials: HS
authors.lastname: Rosenkranz
mesh_terms: D000818:Animals; D005742:Gasoline / Q000633:toxicity*; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics; D016296:Mutagenesis; D051381:Rats; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D005742:Gasoline; D001335:Vehicle Emissions