Evidence that substance-P receptors do not exist in mouse parotid and submandibular acinar cells.
Substance P (SP) had no effect on cytosolic Ca2+ concentration ([Ca2+]i) and inositol phosphate formation in mouse parotid and submandibular acinar cells, but induced a rapid increase in [Ca2+]i and production of inositol phosphates in rat acinar cells. In addition, SP did not stimulate amylase release from mouse parotid acini, but SP-induced amylase release was seen in rats. These results indicate that the mouse lacks SP receptors on parotid and submandibular acinar cells.
Tojyo
Y
Y
Department of Dental Pharmacology, School of Dentistry, Higashi Nippon Gakuen University, Hokkaido, Japan.
Tanimura
A
A
Matsumoto
Y
Y
D000681:Amylases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002217:Carbachol / Q000494:pharmacology; D007295:Inositol Phosphates / Q000096:biosynthesis; D008297:Male; D051379:Mice / Q000378:metabolism*; D010306:Parotid Gland / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D013363:Submandibular Gland / Q000737:chemistry* / Q000378:metabolism; D013373:Substance P / Q000502:physiology*
D007295:Inositol Phosphates; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D013373:Substance P; D002217:Carbachol; D000681:Amylases; D002118:Calcium