title: Palliative treatment of extrahepatic bile ducts tumors.
abstract: Extrahepatic bile duct (EHBD) tumors often become symptomatic in an advanced stage when curative resection is seldom possible. In a group of 111 patients, 7 (6.3%) received no treatment, 32 (28.8%) underwent non-operative biliary drainage (NOD), and 72 (64.8%) underwent surgical exploration. Radical resection was possible in only 25 cases (34.7%); 14 patients (19.4%) underwent a biliary digestive bypass (BDB), 15 (20.8%) received a transtumoral biliary prosthesis (TBP), and 18 (25.0%) an external biliary drainage (EBD). Average survival rates were: 6.5 months after BDB, 4.0 months after TBP, and 2.8 months after EBD. In a second group of 2,066 patients with primary and secondary malignant obstruction of the upper EHBD, treated with the insertion of a Carey-Coons transhepatic transtumoral biliary prosthesis, the average survival was 4.3 months. The early morbidity rate was 0.6%. Obstruction of the prosthesis occurred in 91 patients (4.4%), and the late morbidity rate was 3.6%. Although EHBD tumor treatment results are generally poor, surgical exploration should be performed in all patients with acceptable surgical risk, and without evidence of disseminated disease. When resection of the tumor is not feasible, we favor the use of a BDB or of a biliary prosthesis over that of an external drainage. In poor risk cases or cases with evidence of disseminated disease, we prefer the placement of an internal prosthesis (PTBD or endoscopic.
authors.affiliation: Division of General Surgery, Fatebenefratelli Hospital, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cucchiara
authors.forename: G
authors.initials: G
authors.lastname: Gandini
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
authors.forename: F
authors.initials: F
authors.lastname: Bracci
authors.forename: A
authors.initials: A
authors.lastname: Daffinà
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D001650:Bile Duct Neoplasms / Q000150:complications / Q000601:surgery*; D001652:Bile Ducts / Q000601:surgery; D002404:Catheterization / Q000009:adverse effects / Q000295:instrumentation; D001651:Cholestasis, Extrahepatic / Q000209:etiology / Q000601:surgery*; D004322:Drainage; D004868:Equipment Failure; D005260:Female; D006801:Humans; D007583:Jejunum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D019736:Prostheses and Implants / Q000009:adverse effects; D011475:Prosthesis Failure; D015996:Survival Rate