The vascular E-selectin binds to the leukocyte integrins CD11/CD18.
Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Lex carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.
Kotovuori
P
P
Department of Biochemistry, University of Helsinki, Finland.
Tontti
E
E
Pigott
R
R
Shepherd
M
M
Kiso
M
M
Hasegawa
A
A
Renkonen
R
R
Nortamo
P
P
Altieri
D C
DC
Gahmberg
C G
CG
D015703:Antigens, CD / Q000378:metabolism*; D018845:CD11 Antigens; D018821:CD18 Antigens; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D019040:E-Selectin; D000939:Epitopes / Q000378:metabolism; D016023:Integrins / Q000378:metabolism*; D007962:Leukocytes / Q000737:chemistry* / Q000276:immunology; D007983:Lewis Blood Group Antigens / Q000276:immunology; D011994:Recombinant Proteins / Q000378:metabolism; D014162:Transfection
D015703:Antigens, CD; D018845:CD11 Antigens; D018821:CD18 Antigens; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D000939:Epitopes; D016023:Integrins; D007983:Lewis Blood Group Antigens; D011994:Recombinant Proteins