The Mycobacterium bovis BCG 64-kDa surface protein is antigenically shared with different mouse tumor cells and has anti-tumor activity in immunized mice.
The Mycobacterium bovis BCG 64-kDa surface protein, which was found to share antigenic determinants with line 10 hepatoma cells and showed anti-line 10 tumor activity in immunized guinea pigs, has also been found to share common antigenic determinants with Meth A, CT-26 and RL female 1 mouse tumor cells. The 64-kDa protein also demonstrated anti-tumor activity in immunized mice and 37% of the animals challenged with Meth A tumor cells and 50% of those challenged with CT-26 tumor cells completely rejected further tumor growth in the immunized mice. All these data clearly suggest that BCG 64 kDa protein is probably identical with the tumor specific antigen.
Ahsan
C R
CR
Department of Bacteriology, Hirosaki University School of Medicine, Japan.
Sasaki
J
J
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D007114:Immunization; D015151:Immunoblotting; D008113:Liver Neoplasms / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000276:immunology*; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000276:immunology
D000951:Antigens, Neoplasm; D001426:Bacterial Proteins; D000939:Epitopes