[The treatment of thermal skin burns by using cultured fibroblasts].
Transplants of monolayer culture of human allofibroblasts is characterized morphologically, the experience of their use in the treatment of 184 patients with burns is summarized. Fibroblasts of the transplant are shown to be able to proliferate and to synthetize an extracellular matrix. Their use allowed reducing significantly the time of marginal burn epithelialization, and the epithelialization of donor wounds with long healing and that of deep burns when fibroblast culture transplantation is combined with 1:6 autotransplantation. Rapid recovery of the skin is provided by a transplanted fibroblast stimulation of the proliferation of the granulation tissue pericytes, its fibroblasts and autoepidermocytes.
Glushchenko
E V
EV
Alekseev
A A
AA
Tumanov
V P
VP
Serov
G G
GG
D002056:Burns / Q000473:pathology / Q000601:surgery*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000637:transplantation; D006085:Graft Survival; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D012867:Skin / Q000166:cytology; D016038:Skin Transplantation / Q000379:methods* / Q000473:pathology; D013997:Time Factors; D014184:Transplantation, Homologous; D014945:Wound Healing