[Experimental studies on the effect of dexamethasone on development of anastomotic vascular wall hyperplasia].
In order to determine the effect of anti-inflammatory treatment with dexamethasone on the development of vascular anastomosis hyperplasia, experimental studies were performed in dogs. The animals received synthetic vascular graft implanted into the carotid artery and were given dexamethasone. Group I--control was given no dexamethasone, while group II received it in dose 0.2 mg/kg daily and group III in dose 0.4 mg/kg daily. The follow-up time ranged from four to eight weeks. Then the grafts were taken and subjected to morphological examination. The experiments carried out demonstrated that dexamethasone administered in dose 0.4 mg/kd daily inhibited the development of hyperplasia and delayed healing-in of the vascular grafts.
Stryga
W
W
I Katedry i Kliniki II Wydziału Lekarskiego AM, Warszawie.
D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D002339:Carotid Arteries / Q000473:pathology* / Q000601:surgery; D003907:Dexamethasone / Q000627:therapeutic use*; D004285:Dogs; D004730:Endothelium, Vascular / Q000473:pathology*; D006965:Hyperplasia / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
D003907:Dexamethasone