Inhibitory effects of formaldehyde on the reproductive system of male rats.
Formaldehyde, when administered to rats at a dose of 10 mg/kg body weight/day for a period of 30 days, resulted in a significant fall in sperm motility, viability and count. In addition, the DNA content was significantly lower in testis and prostate while the tissue protein content of prostate and epididymis had decreased in the treated rats. In vitro exposure to formaldehyde also inhibited the sperm motility and viability.
Majumder
P K
PK
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
Kumar
V L
VL
D000818:Animals; D004247:DNA / Q000032:analysis / Q000187:drug effects; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D005557:Formaldehyde / Q000008:administration & dosage / Q000633:toxicity*; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects
D005557:Formaldehyde; D004247:DNA