title: Early afterdepolarizations in a patient with idiopathic monomorphic right ventricular tachycardia.
abstract: To identify the role of afterdepolarizations in the induction of idiopathic monomorphic right ventricular tachycardia (VT), monophasic action potentials (MAPs) were recorded in a patient with this type of VT. The VT had a left bundle branch block configuration and inferior axis, and originated in the right ventricular outflow tract (RVOT). MAPs were recorded with a contact electrode at the origin of the VT, as well as other ventricular sites. The VT was induced by the intravenous administration of isoproterenol and/or rapid ventricular pacing and was preceded by short-long-short sequences of RR intervals. Early afterdepolarizations (EADs) in MAPs were recorded at the origin of VT (RVOT), but not recorded at other ventricular sites. These data suggest that catecholamine sensitive triggered activity seems to be the mechanism of idiopathic monomorphic right VT and EADs can be recorded in association with the occurrence of this type of VT.
authors.affiliation: First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: J
authors.initials: J
authors.lastname: Mukai
authors.forename: K
authors.initials: K
authors.lastname: Nagata
authors.forename: S
authors.initials: S
authors.lastname: Karakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuchioka
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: G
authors.initials: G
authors.lastname: Kajiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuura
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D017180:Tachycardia, Ventricular / Q000503:physiopathology*