Chromosome 12-containing markers, including two dicentrics, in three i(12p)-negative testicular germ cell tumors.
A chromosome 12-derived marker was seen in each of 3 testicular germ cell tumors that lacked the i(12p). An interesting feature of 2 of the markers was that the major part, including the centromere, of an acrocentric (a #13 and #14, respectively) was translocated onto 12p, resulting in a dicentric. In the third tumor, 13q (translocated onto 12q) was again probably involved in the rearrangement. The findings support the view that the amplification of genes on 12p represents a significant step in the development of germ cell tumors.
Atkin
N B
NB
Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, UK.
Fox
M F
MF
Baker
M C
MC
Jackson
Z
Z
D000328:Adult; D002881:Chromosomes, Human, Pair 12 / Q000648:ultrastructure; D002882:Chromosomes, Human, Pair 13 / Q000648:ultrastructure; D002883:Chromosomes, Human, Pair 14 / Q000648:ultrastructure; D004407:Dysgerminoma / Q000235:genetics* / Q000473:pathology; D005784:Gene Amplification; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D013724:Teratoma / Q000235:genetics* / Q000473:pathology; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
D005819:Genetic Markers