A new thymopoietin precursor gene from human thymus.
Thymopoietin-related peptide (TPRP) gene was identified and cloned from a human thymus cDNA library. The cloned cDNA encoded a mature TPRP including the active site of thymopoietin (TP) (residues 32-36). TPRP and bovine TP were very similar in amino acid sequence, each being a 49 amino acid linear polypeptide. TPRP differed in only one residue from bovine putative TP and in only five residues from bovine TP I; whereas TPRP differed much more, at 12 amino acid residues, from human TP from thymus. This suggests that TPRP is a novel peptide and a genuine counterpart of the bovine TP.
Hara
H
H
Clinical Research Center, Utano National Hospital, Kyoto, Japan.
Hayashi
K
K
Ohta
K
K
Itoh
N
N
Ohta
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D009157:Myasthenia Gravis / Q000378:metabolism; D011498:Protein Precursors / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013946:Thymopoietins / Q000235:genetics*; D013950:Thymus Gland / Q000378:metabolism*
D018076:DNA, Complementary; D011498:Protein Precursors; D013946:Thymopoietins; C092927:thymopoietin-related peptide precursor