Focal white-matter lesions in brain of patients with inflammatory bowel disease.
Inflammatory bowel diseases are often associated with extra-intestinal manifestations, such as arthritis and iritis/uveitis. Using magnetic-resonance imaging we found hyperintense focal white-matter lesions in the brain in 20 of 48 (42%) patients with Crohn's disease, in 11 of 24 (46%) patients with ulcerative colitis, but in only 8 of 50 (16%) healthy age-matched controls (relative risk [95% CI] vs controls 2.6 [1.3-5.3] and 2.9 [1.3-6.2], respectively). These findings may represent another extra-intestinal manifestation of inflammatory bowel disease.
Geissler
A
A
Department of Internal Medicine I, University of Regensburg, Germany.
Andus
T
T
Roth
M
M
Kullmann
F
F
Caesar
I
I
Held
P
P
Gross
V
V
Feuerbach
S
S
Schölmerich
J
J
D000328:Adult; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male