[Recombinant antibodies in serologic diagnosis].
In this paper we discuss the value of a new methodology for the production of monoclonal antibodies by recombinant techniques. This approach is especially useful for human monoclonal antibodies due to instability of human antibody-producing cell lines. As an example, we present a recombinant human antibody to the hepatitis C virus (HCV) core protein.
Wölpl
A
A
DRK-Blutspendezentrale Ulm, Abteilung Transfusionsmedizin, Universität Ulm, BRD.
Cardoso
M
M
Siemoneit
K
K
Koerner
K
K
Kubanek
B
B
D000911:Antibodies, Monoclonal / Q000276:immunology; D001782:Blood Donors; D003001:Cloning, Molecular; D006526:Hepatitis C / Q000175:diagnosis*; D006801:Humans; D016133:Polymerase Chain Reaction; D012698:Serologic Tests / Q000379:methods*; D014758:Viral Core Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus