title: Induction of an adaptive response to dominant lethality and to chromosome damage of mouse germ cells by low dose radiation.
abstract: In the present paper, dominant lethal mutations, chromosome aberrations in spermatocytes and reciprocal translocations in stem spermatogonia were analyzed after whole body exposure of mice to X-radiation. Results both from chromosome aberrations in spermatocytes and for reciprocal translocations in spermatogonia showed that pre-exposure to low doses up to 200 mGy could induce a significant dose-dependent reduction in adapted mice compared to the non-adapted mice; the lower the adaptive dose, the greater the reduction. For dominant lethal mutations, it was found that spermatogonia (both stem cells and differentiated cells) and spermatocytes adapted to 50 mGy X-rays could show an adaptive response, but spermatids and spermatozoa could not.
authors.affiliation: Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Cai
authors.forename: J
authors.initials: J
authors.lastname: Jiang
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Yao
authors.forename: X
authors.initials: X
authors.lastname: Wang
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009154:Mutation; D011829:Radiation Dosage; D013087:Spermatids / Q000528:radiation effects; D013094:Spermatozoa / Q000528:radiation effects* / Q000648:ultrastructure; D014178:Translocation, Genetic; D014916:Whole-Body Irradiation; D014965:X-Rays