title: [The hypolipidemic effect of and tolerance for Lescol in treating hypercholesterolemia in hypertension patients (an analysis of the data from a multicenter study)].
abstract: Hypertensive patients with hyperlipidemia are at high risk to develop coronary heart disease (CHD). Chemotherapeutic correction of hyperlipidemia seems most reliable modality to prevent CHD. Hypolipidemic effect and tolerance of leskol (fluvastatin) in dietotherapy-resistant hypercholesterolemia were studied in 74 patients with essential hypertension treated with hypotensive drugs. The patients were included in a multicenter trial. A 12-week course reduced total cholesterol level under 6.2 mmol/l in 59% of the patients, under 5.2 mmol/l in 29% of them. LDLP cholesterol lowered to 3.5% in 34% of the patients. Mean apo B diminished by 23%. There was a 27% decrease in the proportion of atherogenic fraction apo B to antiatherogenic fraction of transport proteins apo A-I. Leskol is well tolerated and effective against hypercholesterolemia, it is safe in relation to side effects and blood biochemistry.
authors.forename: D M
authors.initials: DM
authors.lastname: Aronov
authors.forename: N M
authors.initials: NM
authors.lastname: Akhmedzhanov
authors.forename: O A
authors.initials: OA
authors.lastname: Vartanova
authors.forename: T M
authors.initials: TM
authors.lastname: Volchkova
authors.forename: N A
authors.initials: NA
authors.lastname: Gratsianskiĭ
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Ivleva
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Kobalava
authors.forename: O E
authors.initials: OE
authors.lastname: Mel'kina
authors.forename: V S
authors.initials: VS
authors.lastname: Moiseev
authors.forename: A M
authors.initials: AM
authors.lastname: Olfer'ev
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D004361:Drug Tolerance; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D000077340:Fluvastatin; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007211:Indoles / Q000009:adverse effects / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009031:Moscow; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D005229:Fatty Acids, Monounsaturated; D007211:Indoles; D008055:Lipids; D000077340:Fluvastatin