[The role of hemorheologic disturbance in experimental acute pancreatitis].
The role of hemorheologic disturbance in experimental acute pancreatitis was studied in Wistar male rats. It was found that pancreatic duct obstruction with secretin stimulation could induce acute interstitial pancreatitis (AIP), but when high molecular dextran intravenous injection being added, acute necrotizing pancreatitis (ANP) was induced. The authors suggest that the high molecular dextran can increase blood viscosity, aggregation of erythrocytes and decrease erythrocyte deformability, which results in pancreatic microcirculatory disturbances and promotes progressive pancreatic necrosis. Hemorheologic disturbance is one of the key factors in the pathogenesis of ANP.
Yan
L
L
Lei
Z
Z
Cui
X
X
Chen
H
H
Yang
Y
Y
Li
L
L
Tan
J
J
Chen
L
L
Wu
H
H
Li
K
K
D000208:Acute Disease; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D003911:Dextrans / Q000009:adverse effects; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects; D008297:Male; D008833:Microcirculation; D009336:Necrosis; D010195:Pancreatitis / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
D003911:Dextrans