[Combined effects of anti-Pseudomonas antibiotics with G-CSF on systemic infections by Pseudomonas aeruginosa in a leukocytopenic mouse model].
A model with cyclophosphamide-induced leukocytopenic mice was employed to investigate combined effects of each of several antibiotics (sulbactam/cefoperazone (SBT/CPZ), ceftazidime, piperacillin and imipenem/cilastatin (IPM/CS)) with G-CSF on systemic infections caused by Pseudomonas aeruginosa. The ED50's of all the antibiotics except that of SBT/CPZ in these leukocytopenic mice were approximately two-fold higher than those in normal mice. No differences were observed between 2 groups of mice, one administered with G-CSF and the other without G-CSF, hence no additive or synergistic effects were observed between G-CSF and there antibiotics. With SBT/CPZ, however, the G-CSF-administered group showed higher ED50 than the group without G-CSF, and the ED50 of the former group was similar to that of normal mice, thus a synergistic effect was observed between SBT/CPZ and G-CSF.
Kaneko
A
A
Department of Dentistry and Oral Surgery, Ashikaga Red Cross Hospital.
Tomita
F
F
Kobayashi
I
I
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D007970:Leukopenia / Q000150:complications*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D000900:Anti-Bacterial Agents; D016179:Granulocyte Colony-Stimulating Factor