title: Ascorbic acid is cytotoxic for pediatric tumor cells cultured in vitro.
abstract: 2 mM Ascorbic acid has a potent cytotoxic effect on neuroblastoma, osteosarcoma, retinoblastoma, and rhabdomyosarcoma cells cultured in vitro. At a lower concentration (0.2 mM), ascorbic acid remains highly cytotoxic for neuroblastoma, osteosarcoma and retinoblastoma cells, but it has a stimulatory effect on the growth of rhabdomyosarcoma cells.
authors.affiliation: Sektion Onkologie/Immunologie, Universitäts Kinderklinik, Ruprecht-Karls-Universität, Heidelberg, Germany.
authors.forename: M A
authors.initials: MA
authors.lastname: Medina
authors.forename: R
authors.initials: R
authors.lastname: García de Veas
authors.forename: L
authors.initials: L
authors.lastname: Schweigerer
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D003603:Cytotoxins; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D001205:Ascorbic Acid