title: Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro.
abstract: Bovine papillomavirus E1 protein was found to be as efficient as the simian virus 40 large T antigen in initiating DNA synthesis in a cell-free system derived from COS1 cells. Multiple rounds of DNA synthesis occur, initiated at the bovine papillomavirus type 1 origin. Therefore, E1 functions in vitro as a lytic virus initiator.
authors.affiliation: Centre de Biochimie, Unité 273 de l'Institut National de la Santé et de la Recherche Médicale, Nice, France.
authors.forename: C
authors.initials: C
authors.lastname: Bonne-Andrea
authors.forename: S
authors.initials: S
authors.lastname: Santucci
authors.forename: P
authors.initials: P
authors.lastname: Clertant
mesh_terms: D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000378:metabolism; D052688:Bovine papillomavirus 1 / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D002417:Cattle; D002460:Cell Line; D004261:DNA Replication / Q000235:genetics; D004279:DNA, Viral / Q000096:biosynthesis*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D066298:In Vitro Techniques; D018741:Replication Origin; D013539:Simian virus 40 / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D000952:Antigens, Polyomavirus Transforming; D004279:DNA, Viral; D004268:DNA-Binding Proteins; C069814:E1 protein, Bovine papillomavirus; D014764:Viral Proteins