Effect of prostaglandin F2 alpha on transmural potential difference and short-circuit current in isolated frog (Rana catesbeiana) skin.
1. Addition of prostaglandin F2 alpha to the inside bathing solution elicited sustained decreases in transmural potential difference and short-circuit current. 2. Addition of indomethacin to the inside bathing solution partially inhibited transmural potential difference and short-circuit current. 3. Addition of indomethacin to the inside bathing solution further decreased the prostaglandin F2 alpha effect on transmural potential difference and short-circuit current. 4. The prostaglandin F2 alpha-induced effects on short-circuit current were carried by a net active sodium transfer from the outside to the inside bathing solution.
Gerencser
G A
GA
Department of Physiology, JHMHC, College of Medicine, University of Florida, Gainesville 32610.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D015237:Dinoprost / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects; D005260:Female; D007473:Ion Channels / Q000187:drug effects*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011892:Rana catesbeiana; D012867:Skin / Q000187:drug effects*
D007473:Ion Channels; D015237:Dinoprost