title: Effect of methionine supplementation to a low-soybean protein diet on liver lipid metabolism.
abstract: Female Wistar rats were fed a low-soybean protein (8%) diet supplemented with different concentrations of DL-methionine (0-1.2%) during the lactation period. Diet supplementation with methionine caused a significant increase in rat body weight. The addition of 0.3% DL-methionine to the diet did not cause an increase in liver triacylglycerol concentration in 21-day-old rats, but an increase did occur after the addition of 0.6% DL-methionine to the diet. Supplementation of the diet with DL-methionine did not change liver phospholipid or protein concentrations, nor plasma triacylglycerol levels. Liver lipid synthesis from [1-14C]acetate in 21-day-old rats whose dams had been fed an 8% soybean protein diet supplemented with 1.2% DL-methionine was significantly higher than in the group receiving no DL-methionine supplementation. Hepatic production of CO2 and of water-soluble acid products from [1-14C]palmitate did not differ between groups. Inositol addition to a low-soybean protein diet supplemented with DL-methionine did not change triacylglycerol nor phospholipid levels in the liver.
authors.affiliation: Department of Physiological Sciences, FFFCMPA, Porto Alegre, R.S., Brazil.
authors.forename: A M
authors.initials: AM
authors.lastname: de Azevedo
authors.forename: I R
authors.initials: IR
authors.lastname: Azzolin
authors.forename: M L
authors.initials: ML
authors.lastname: Perry
mesh_terms: D000085:Acetates / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D005527:Food, Fortified; D007774:Lactation / Q000502:physiology; D050356:Lipid Metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008715:Methionine / Q000494:pharmacology*; D010168:Palmitates / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis / Q000097:blood; D014674:Plant Proteins, Dietary / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins; D013025:Glycine max; D014280:Triglycerides / Q000032:analysis / Q000097:blood
chemical_list: D000085:Acetates; D002250:Carbon Radioisotopes; D004044:Dietary Proteins; D010168:Palmitates; D010743:Phospholipids; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D014280:Triglycerides; D008715:Methionine