title: Histamine release during paediatric cardiopulmonary bypass.
abstract: Histamine release is part of the general inflammatory response and occurs during surgery and cardiopulmonary bypass (CPB) in adults. Few data are available for children. Histamine release was studied in 23 children undergoing CPB with standard anaesthetic and CPB techniques. Blood sampling was performed in relation to specific anaesthetic and surgical events, e.g., start of CPB, removal of aortic clamps, reventilation of the lungs. Plasma histamine was determined by a single isotope radioenzymatic technique. There was no consistent histamine release in the study population although there was an increase in plasma histamine concentration in some subjects after initiation of CPB (P < 0.05) and on removal of the aortic cross-clamp (P < 0.05). No correlation was demonstrated between histamine concentration and systolic arterial pressure, temperature, duration of CPB or cross-clamp time. Histamine concentration was positively correlated with heart rate.
authors.affiliation: Department of Anaesthesia, St. Thomas' Hospital, London, U.K.
authors.forename: D E
authors.initials: DE
authors.lastname: Withington
authors.forename: W K
authors.initials: WK
authors.lastname: Man
authors.forename: M J
authors.initials: MJ
authors.lastname: Elliott
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General; D000777:Anesthetics / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D003521:Cyclopropanes / Q000494:pharmacology; D006324:Heart Arrest, Induced; D006330:Heart Defects, Congenital / Q000601:surgery*; D006339:Heart Rate / Q000502:physiology; D006493:Heparin / Q000627:therapeutic use; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007223:Infant; D011479:Protamines / Q000627:therapeutic use; D012121:Respiration, Artificial; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000777:Anesthetics; D003521:Cyclopropanes; D011479:Protamines; D006632:Histamine; D006493:Heparin; C030797:cyclopropane; D013874:Thiopental