title: Primary structure and functional expression of a cyclic nucleotide-gated channel from rabbit aorta.
abstract: Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sino-atrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Technischen Universität München, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Biel
authors.forename: W
authors.initials: W
authors.lastname: Altenhofen
authors.forename: R
authors.initials: R
authors.lastname: Hullin
authors.forename: J
authors.initials: J
authors.lastname: Ludwig
authors.forename: M
authors.initials: M
authors.lastname: Freichel
authors.forename: V
authors.initials: V
authors.lastname: Flockerzi
authors.forename: N
authors.initials: N
authors.lastname: Dascal
authors.forename: U B
authors.initials: UB
authors.lastname: Kaupp
authors.forename: F
authors.initials: F
authors.lastname: Hofmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001011:Aorta / Q000737:chemistry*; D001483:Base Sequence; D002417:Cattle; D003062:Codon; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004594:Electrophysiology; D015870:Gene Expression; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects*; D007473:Ion Channels / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D011817:Rabbits; D017386:Sequence Homology, Amino Acid
chemical_list: D003062:Codon; D007473:Ion Channels; D004247:DNA; D000242:Cyclic AMP; D006152:Cyclic GMP