Heterogeneity of CD7+ 4- 8- 1- leukemia: usefulness of cytoplasmic antigen detection for subclassification.
We identified CD3 and myeloperoxidase (MPO) antigens in the cytoplasm of leukemic cells from 15 patients with CD7+ 4- 8- 1- leukemia. Seven patients, five of whom had a mediastinal mass, had only cytoplasmic CD3 (cCD3) antigen; these seven were regarded as possibly being of T-lineage type. Six patients, one of whom had a mediastinal mass, showed both cCD3 and MPO; they were considered to have mixed lineage type. Two patients had neither cCD3 nor cytoplasmic myeloid antigens; they were therefore considered to have stem cell type. These two latter types were considered as the subgroups: mixed lineage or stem cell type. Patients with T-lineage type were good responders to L-17M therapy; four out of five who received L-17M therapy achieved complete remission. There were significant differences between the two subgroups in relapse-free survival, patients with T-lineage type exhibiting better prognosis than other types (p < 0.05).
Masuda
M
M
Department of Hematology, Tokyo Women's Medical College, Japan.
Arai
Y
Y
Osawa
M
M
Kaneko
T
T
Aoyama
M
M
Motoji
T
T
Oshimi
K
K
Mizoguchi
H
H
D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D017252:CD3 Complex / Q000032:analysis; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007938:Leukemia / Q000145:classification* / Q000276:immunology / Q000401:mortality; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000201:enzymology / Q000276:immunology / Q000401:mortality; D008297:Male; D009195:Peroxidase / Q000032:analysis; D011379:Prognosis; D015996:Survival Rate
D015703:Antigens, CD; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D009195:Peroxidase