title: Thermoradiotherapy combined with a proteolysis inhibitor (contrical) in the treatment of head and neck cancer.
abstract: For the prophylaxis of head and neck cancer recurrence and metastases we used radiation therapy, microwave hyperthermia and adjuvant therapy (inhibitor of proteolysis contrical and alpha-interferon). One hundred forty patients with primary cancer were treated. After 1 year of observation time and absence of tumor the patients were examined once every 3 months. The use of contrical and interferon combined with radiation therapy and microwave hyperthermia increased the 3-year survival rate by 37%, the number of patients without recurrence by 39% and decreased the appearance of regional metastases to 8.4%. Adjuvant therapy is discussed.
authors.affiliation: Division of Oncology, Kiev Research Institute of Otolaryngology, Ukraine.
authors.forename: I A
authors.initials: IA
authors.lastname: Mikhalkin
authors.forename: Z G
authors.initials: ZG
authors.lastname: Iashvili
authors.forename: V L
authors.initials: VL
authors.lastname: Bykov
mesh_terms: D007611:Aprotinin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000517:prevention & control*; D011879:Radiotherapy Dosage
chemical_list: D007611:Aprotinin