[Effect of fentanyl on the contractile capacity of the aerobically perfused isolated rat heart].
Addition of fentanyl (1.84.10(-7) M) to a circulating solution was shown to unchange the baseline functional potentialities of the myocardium. However, at min 60 of the experiments, these hearts were different from the control ones in the values of aortic blood flow, cardiac output and left ventricular dP/dt. Their functional stability was accounted for by the preserved myocardial capacity to relax and hence to heterometrically autoregulate.
Chernikov
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D000332:Aerobiosis; D000818:Animals; D005283:Fentanyl / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar
D005283:Fentanyl