Localization of the human interferon-induced, ds-RNA activated p68 kinase gene (PRKR) to chromosome 2p21-p22.
The interferon-induced dsRNA-activated protein kinase (PRKR) belongs to a subclass of serine/threonine kinases, involved in the regulation of protein synthesis by phosphorylation of the alpha subunit of initiation factor eIF2. Somatic cell hybrids segregating human chromosomes were used to assign this kinase to human chromosome 2. Fluorescence in situ hybridization confirmed this assignment and further localized the gene (PRKR) to the boundary region of bands p21 and 22.
Squire
J
J
Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
Meurs
E F
EF
Chong
K L
KL
McMillan
N A
NA
Hovanessian
A G
AG
Williams
B R
BR
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D004789:Enzyme Activation; D004790:Enzyme Induction; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007372:Interferons / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000378:metabolism; D019892:eIF-2 Kinase
D012330:RNA, Double-Stranded; D007372:Interferons; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase