Genetic factors determine the blood pressure response to insulin resistance and hyperinsulinemia: a call to refocus the insulin hypothesis of hypertension.
We have briefly reviewed the controversy regarding the role of insulin resistance and hyperinsulinemia in the pathogenesis of hypertension in an attempt to emphasize the evidence in support of this concept. In so doing, we have highlighted the concept that genetic factors may determine sensitivity or resistance to the hypertensive effects of insulin resistance and hyperinsulinemia. We hope that this idea will help to reconcile seemingly conflicting evidence on this hypothesis and will focus future research.
Mark
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AL
Cardiovascular Center, University of Iowa, Iowa City.
Anderson
E A
EA
D000818:Animals; D001794:Blood Pressure; D006801:Humans; D006946:Hyperinsulinism / Q000235:genetics / Q000503:physiopathology*; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology*; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000502:physiology / Q000503:physiopathology; D009765:Obesity / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology; D012307:Risk Factors
D007328:Insulin