[Preliminary study on pharmacologic action of Ligustrum japonicum].
The results of treatment with the Ligustrum japonicum Thunb. Var. Pubescens Koidz (LJ) in rabbits' model of hyperlipemia and atherosclerosis was observed. The results showed: (1) By the end of first to third month, the levels of serum TL and TC in groups B,C were lower than that of group A and there was significant difference between them (P < 0.05), the level of serum TG in groups B,C was lower than that of group A too, but there was no significant difference between them (P > 0.05). (2) By the end of first and second month, the level of serum LPO in groups B,C was lower than that of group A and there were significant difference between them (P < 0.05, 0.01), while there was no significant difference between group B and group C (P > 0.05). (3) The rabbits were sacrificed by the end of third month, arteriosclerotic area of aorta in groups B,C were less than that of group A, and that of group B was even less than group C, there was significant difference between group A and B (P < 0.01). (4) By the end of third month, the level of HCT in groups B,C was lower than that of group A and there was significant difference between them (P < 0.05), but there was no significant difference between group B and group C (P > 0.05). These results showed that LJ could lower the levels of serum TL, TC, LPO, HCT and anti-arteriosclerosis as well, it could prevent cerebro- and cardio-vascular disease as the clofibrate.(ABSTRACT TRUNCATED AT 250 WORDS)
Wang
S S
SS
Institute of Cerebro-Vascular Diseases, Qiannan, Guizhou.
Chen
J H
JH
Liu
X J
XJ
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006949:Hyperlipidemias / Q000473:pathology / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000633:toxicity; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D051379:Mice; D011817:Rabbits
D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; D008054:Lipid Peroxides; D002784:Cholesterol