Hodgkin's disease associated with central pontine myelinolysis.
We describe a 12-year-old black male who presented with cervical lymphadenopathy, hepatosplenomegaly of 3 months duration, and ataxia and incoordination of recent onset. Hodgkin's disease, stage IVB, was diagnosed. An MRI of the head demonstrated a nonenhancing, well-defined pontine lesion. The pontine lesion and the associated neurologic symptoms were consistent with central pontine myelinolysis. Treatment of Hodgkin's disease resulted in complete remission and complete disappearance of the pontine abnormality.
Chintagumpala
M M
MM
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Mahoney
D H
DH
McClain
K
K
Dreyer
Z E
ZE
Fishman
M A
MA
Carrol
C L
CL
Steuber
C P
CP
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D002648:Child; D003606:Dacarbazine / Q000008:administration & dosage; D003711:Demyelinating Diseases / Q000209:etiology*; D004317:Doxorubicin / Q000008:administration & dosage; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D011149:Pons / Q000000981:diagnostic imaging / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D014747:Vinblastine; D014750:Vincristine / Q000008:administration & dosage
D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D011241:Prednisone