title: Capillary pulse waveform in aortic stenosis.
abstract: The importance of the dynamic nature of perfusion pressure within the peripheral microcirculation is increasingly recognised. Capillary pressure is determined not only by arterial inflow pressure, but is also subject to a variety of local and systemic influences which have been shown to affect both mean pressure and the capillary pulse waveform. To what extent changes in central pulse waveform influence capillary pressure has yet to be determined. By using a dynamic technique of capillary pressure measurement in human subjects with aortic stenosis, we have been able to show that the characteristics of the pulse waveform typically associated with large vessels in this condition are also readily detectable at a capillary level despite local influences. However, changes in the rate of pulse wave transmission described in large arteries were not apparent at a microvascular level. Unlike mean capillary pressure and capillary pulse pressure, pulse waveform in the capillary mimics central haemodynamics.
authors.affiliation: Department of Vascular Medicine, Postgraduate Medical School, University of Exeter, UK.
authors.forename: I R
authors.initials: IR
authors.lastname: Mahy
authors.forename: A C
authors.initials: AC
authors.lastname: Shore
authors.forename: L D
authors.initials: LD
authors.lastname: Smith
authors.forename: J E
authors.initials: JE
authors.lastname: Tooke
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D002196:Capillaries / Q000502:physiology; D016022:Case-Control Studies; D004562:Electrocardiography; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000502:physiology*; D013599:Systole / Q000502:physiology