[Hyperlipidemia as a factor of myocardial damage (experimental study)].
To elucidate the assumed direct negative effect of huperlipidemia (HL) on the myocardium, histological and electron microscopic studies of the myocardia of rabbits with alimentary hypercholesterolemia which were on an atherogenic diet for 30 days and underwent transesophageal pacing tests were conducted. An experimental group comprised 7 rabbits with HL, a control one included 4 animals. In HL rabbits, the cardiac pacing test caused irreversible myocardial histomorphological changes. In normolipidemic rabbits this caused only myocardial functional overload and histological changes were moderate and reversible. The findings suggest that HL contributes to myocardial hypoxic damage due to impaired microcirculation and tissue diffusion of oxygen with higher myocardial oxygen demand.
Lipovetskiĭ
B M
BM
Konstantinov
V O
VO
Zel'tser
G L
GL
Amineva
Kh K
KhK
D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology* / Q000473:pathology; D006937:Hypercholesterolemia / Q000150:complications* / Q000473:pathology; D011817:Rabbits