[Pseudopancreatitis in entero-invasive salmonellosis].
The incidence of pancreatitis in bacterial enterocolitis is disputed. Two cases of young patients with S. enteritidis-induced enterocolitis and markedly elevated amylase and lipase blood levels are described. In both patients there were neither clinical nor ultrasonographic signs of pancreatitis. Furthermore, both had increased intestinal permeability for oral 51Cr-EDTA, a condition discussed as "leaky gut" in other publications. In one patient enzyme levels and 51Cr-EDTA resorption became rapidly normal, while in the other the values remained elevated after a 7-month interval with stool culture negative. Enhanced intestinal absorption of 51Cr-EDTA (mw 391) suggests--but does not definitely prove--an inflammatory response of the mucosa leading to increased intestinal permeability, which in turn may allow resorption of amylase (mw 62,000), lipase (43,000) or other macromolecules. Performance of a 51Cr-EDTA resorption test may be helpful in cases of clinical uncertainty.
Gnädinger
M P
MP
Medizinische Klinik A, Kantonsspital St. Gallen.
Eigenmann
F
F
Bekier
A
A
Galeazzi
R L
RL
D000328:Adult; D000681:Amylases / Q000097:blood*; D002860:Chromium Radioisotopes; D003937:Diagnosis, Differential; D004492:Edetic Acid; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008049:Lipase / Q000097:blood*; D008297:Male; D010195:Pancreatitis / Q000097:blood*; D012478:Salmonella Food Poisoning / Q000097:blood* / Q000382:microbiology / Q000503:physiopathology; D012477:Salmonella enteritidis / Q000302:isolation & purification
D002860:Chromium Radioisotopes; D004492:Edetic Acid; D008049:Lipase; D000681:Amylases