[The significance of cardiolipin antibodies in systemic lupus erythematosus].
The aim of the study was to investigate the frequency and clinical significance of anticardiolipin antibodies (aCL) in systemic lupus erythematosus (SLE). 32 of 100 patients with SLE had positive anticardiolipin antibodies. Increased aCL were associated with thrombosis, thrombocytopenia, miscarriage, vasculitic skin changes and neurological symptoms. The incidence of thrombosis, thrombocytopenia, and neurological symptoms was significantly increased in the aCL-positive group as compared to the aCL-negative group. These findings confirm the results of former investigations and underline the role of aCL in systemic lupus erythematosus.
Gansauge
S
S
Medizinische Klinik und Poliklinik V, Universität Heidelberg.
Breitbart
A
A
Brado
B
B
von Baum
H
H
Rinaldi
N
N
Werle
E
E
Schwarz-Eywill
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D002308:Cardiolipins