title: Antarelix (EP 24332) a novel water soluble LHRH antagonist.
abstract: A novel water soluble LHRH antagonist (EP 24332-Antarelix) is described. Its activity in vitro and in vivo in several animal models is given. Antarelix (Ac-D-Nal, D-Cpa, D-Pal, Ser, Tyr, D-Hci, Leu, Lys-(iPr), Pro, D-Ala-NH2) in view of its potency, modest histamine-liberating activity and high water solubility has been selected for further development.
authors.affiliation: Europeptides, Argenteuil, France.
authors.forename: R
authors.initials: R
authors.lastname: Deghenghi
authors.forename: F
authors.initials: F
authors.lastname: Boutignon
authors.forename: P
authors.initials: P
authors.lastname: Wüthrich
authors.forename: V
authors.initials: V
authors.lastname: Lenaerts
mesh_terms: D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility
chemical_list: D009842:Oligopeptides; D007987:Gonadotropin-Releasing Hormone; C084350:antarelix