title: Prospects for new hormonal male contraceptives.
abstract: Overpopulation is a paramount global crisis, as it underlies virtually all major worldwide problems, including poverty, malnutrition, and warfare. It is imperative that proliferation be curbed by expediting reductions in fertility. This article discusses the demand for and acceptability of male contraceptives and the process of spermatogenesis. Endocrine control of spermatogenesis, and potential sites for disruption of male fertility, including steroid combinations and GnRH agonists and antagonists are reviewed also. Risks and benefits of these approaches are considered.
authors.affiliation: University of Washington, Seattle.
authors.forename: D E
authors.initials: DE
authors.lastname: Cummings
authors.forename: W J
authors.initials: WJ
authors.lastname: Bremner
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000592:standards; D000728:Androgens / Q000494:pharmacology / Q000502:physiology / Q000592:standards*; D003272:Contraceptive Agents, Male / Q000009:adverse effects / Q000494:pharmacology / Q000592:standards*; D005640:Follicle Stimulating Hormone / Q000276:immunology; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006801:Humans; D008297:Male; D013091:Spermatogenesis / Q000187:drug effects / Q000502:physiology
chemical_list: D000726:Androgen Antagonists; D000728:Androgens; D003272:Contraceptive Agents, Male; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone