Pulmonary clearance of tracers with different lipid and water solubility in experimental surfactant dysfunction.
We measured the pulmonary clearance of inhaled 99mTc-diethylenetriamine penta-acetic acid (DTPA), 99mTc-sestamibi and 99mTc-dimethyliminodiacetic acid (HIDA) in normal rabbits, and rabbits with surfactant dysfunction induced by the detergent dioctyl sodium sulfosuccinate. The tracers differ widely in lipid/water partition coefficients, but have similar molecular radius and weight. Five animals in each group received the detergent in aerosol, and the other five a vehicle aerosol, before the administration of the tracer. Pulmonary clearance of the tracers was measured with a gamma camera. The half-life of 99mTc-DTPA was 94 +/- 16 min in normal lungs, and 10 +/- 1 min after detergent administration (p < 0.001). The half-life for 99mTc-sestamibi was 45 +/- 4 min and 39 +/- 4 min, respectively, (p < 0.05). There was no significant difference between the half-life of 99mTc-HIDA in normal lungs and in lungs with surfactant dysfunction. The half-life was 20 +/- 3 min and 17 +/- 2 min, respectively. The results indicate that the clearance rate limiting factors for the alveolocapillary transfer of water and lipid soluble substances are not the same. Surfactant dysfunction affects the transfer of water soluble substances (99mTc-DTPA) but not of substances with high lipid solubility (99mTc-HIDA).
Nilsson
K
K
Dept of Clinical Physiology, University of Lund, Sweden.
Wollmer
P
P
D000336:Aerosols; D000818:Animals; D015824:Blood-Air Barrier / Q000502:physiology*; D003902:Detergents / Q000494:pharmacology; D004143:Dioctyl Sulfosuccinic Acid / Q000494:pharmacology; D006207:Half-Life; D007098:Imino Acids; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology; D015609:Organotechnetium Compounds; D011663:Pulmonary Surfactants / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D011877:Radionuclide Imaging; D019780:Technetium Tc 99m Lidofenin; D016284:Technetium Tc 99m Pentetate; D017256:Technetium Tc 99m Sestamibi
D000336:Aerosols; D003902:Detergents; D007098:Imino Acids; D015609:Organotechnetium Compounds; D011663:Pulmonary Surfactants; D004143:Dioctyl Sulfosuccinic Acid; D019780:Technetium Tc 99m Lidofenin; D017256:Technetium Tc 99m Sestamibi; D016284:Technetium Tc 99m Pentetate