title: Sequential occurrence of IgA nephropathy and Henoch-Schönlein purpura: support for common pathogenesis.
abstract: We report a patient who developed Henoch-Schönlein purpura (HSP) 13 years after he presented with IgA nephropathy (IgAN). In both HSP and IgAN renal biopsy most commonly reveals focal proliferative glomerulonephritis on light microscopy and immunofluorescence displays mesangial IgA deposits. In addition, patients with HSP or IgAN have elevated serum IgA levels, circulating IgA immune complexes, IgA-bearing lymphocytes, immunoglobulin-producing cells, and binding of IgG to glomerular components of similar molecular weight. The occurrence of both diseases in the same patient or the same families and the presence of immune abnormalities compatible with HSP or IgAN in relatives of patients with these diseases suggest a common pathogenesis.
authors.affiliation: Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: D M
authors.initials: DM
authors.lastname: Silverstein
authors.forename: I
authors.initials: I
authors.lastname: Greifer
authors.forename: V
authors.initials: V
authors.lastname: Folkert
authors.forename: B
authors.initials: B
authors.lastname: Bennett
authors.forename: H E
authors.initials: HE
authors.lastname: Corey
authors.forename: A
authors.initials: A
authors.lastname: Spitzer
mesh_terms: D000328:Adult; D005922:Glomerulonephritis, IGA / Q000276:immunology* / Q000473:pathology; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology* / Q000473:pathology; D007070:Immunoglobulin A / Q000097:blood; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008856:Microscopy, Fluorescence; D012189:Retrospective Studies
chemical_list: D007070:Immunoglobulin A