Synthesis and pharmacological screening of novel 10-substituted diazepino-[2,1-f]-purines.
Two series of N10 substituted derivatives of 1,3-dimethyl-2,4,9-trioxo-1,3,6,7,8,10-hexahydro-1,3-diazepino+ ++-[2,1-f]- purine and 1,3-dimethyl-2,4-dioxo-1,3,6,7,8,9-hexahydro-10H-1,3-dizepino- [2,1-f]-purine were synthesized and tested for CNS activity. The most active in central nervous system tests were compounds [II] and [XIV].
Pawłowski
M
M
Department of Pharmaceutical Chemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Drabczyńska
A
A
Gorczyca
M
M
Malec
D
D
Modzelewski
J
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D015195:Drug Design; D004347:Drug Interactions; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011687:Purines / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
C092800:8-aminotheophylline-7-butyric acid; D002491:Central Nervous System Agents; D011687:Purines; D013806:Theophylline