Determination of amiodarone in tablets and plasma by high-performance liquid chromatography.
A method is described for measuring amiodarone in human plasma and tablets using a LiChrosorb RP-18 column, a mobile phase methanol-acetonitrile-phosphate buffer pH 2.6 (80:15:5, v/v) and UV detection at 254 nm. Another antiarrhythmic drug - aprindine was used as an internal standard (i.s.).
Gumieniczek
A
A
Department of Medicinal Chemistry, School of Medicine, Lublin, Poland.
Misztal
G
G
Przyborowski
L
L
D000638:Amiodarone / Q000032:analysis* / Q000097:blood; D001073:Aprindine / Q000032:analysis / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012015:Reference Standards; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D013607:Tablets; D001073:Aprindine; D000638:Amiodarone