title: Aggressive surgical therapy for Klatskin tumors.
abstract: Thirty-one patients underwent limited hepatic resection with Roux-en-Y biliary-enteric anastomosis and placement of biliary stents for cholangiocarcinoma of the hepatic duct bifurcation (Klatskin tumor). Resection included wide tumor excision and bile duct resection at the liver hilum without major hepatic resection and was undertaken in all patients unless precluded by intraoperative evidence of vascular invasion. All patients were operated on by a single surgeon during the 10 years between 1981 and 1991. Similar procedures were performed for both curative (n = 17) and palliative (n = 14) treatment of this disease entity. In this series, the overall mean postoperative survival of these patients was 17 months. The mean postoperative survival of patients undergoing surgery with curative intent was 21 months in contrast to 12 months for those undergoing planned palliation. One patient in this series has been alive for more than 6 years with no evidence of disease. Five patients experienced major postoperative complications (16%), and there were two perioperative deaths (6%). This retrospective review supports an aggressive surgical approach in patients with Klatskin tumor.
authors.affiliation: Department of Surgery, Swedish Medical Center/Seattle, Washington 98104.
authors.forename: T
authors.initials: T
authors.lastname: Childs
authors.forename: M
authors.initials: M
authors.lastname: Hart
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000601:surgery; D000231:Adenocarcinoma, Papillary / Q000401:mortality / Q000601:surgery; D002759:Adenoma, Bile Duct / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000401:mortality / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006500:Hepatic Duct, Common; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011183:Postoperative Complications; D012189:Retrospective Studies; D015996:Survival Rate