[Inhibition of human immunodeficiency virus replication by azidothymidine (Azitidín Lachema) in cultured cells].
The inhibitory effect of the Czecho-Slovakia azidothymidine (AZT) preparation Azitidin (Lachema) on HIV 1 infection was studied in vitro. Its efficacy was compared with that of the approved AZT preparation Retrovir (Burroughs-Wellcome Co.). HIV 1 infected MT4 cells were cultivated in media containing different concentrations of Azitidin or Retrovir. Complete inhibition of virus production (reverse transcriptase activity) and of the cytopathic effect of HIV 1 was seen at the concentration of 0.1 microM of either preparation. Complete inhibition of viral antigen induction was recorded at the concentration of 1 microM. In the light of the obtained results we can conclude that Azitidin inhibits HIV 1 replication in vitro and its efficacy is fully comparable to that of Retrovir. (Tab. 4, Fig. 2, Ref. 17.)
Schmidtmayerová
H
H
Virologický ústav SAV, Bratislava, Slovakia.
Mayer
V
V
D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006678:HIV / Q000187:drug effects / Q000502:physiology*; D015488:HIV Antigens / Q000032:analysis / Q000187:drug effects; D006801:Humans; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology*
D015488:HIV Antigens; D015215:Zidovudine; D012194:RNA-Directed DNA Polymerase