title: Delayed appearance of anti-myelin-associated glycoprotein antibodies in a patient with chronic demyelinating polyneuropathy.
abstract: A patient who had a polyneuropathy compatible with a chronic inflammatory demyelinating polyneuropathy and was initially negative for anti-myelin-associated glycoprotein (MAG) antibodies developed a double monoclonal gammopathy, IgM kappa and IgM lambda, two years after the diagnosis. The IgM kappa, but not the IgM lambda, exhibited strong anti-MAG antibody activity. The late appearance of the anti-MAG immunoreactivity suggests that in patients with an initial diagnosis of chronic inflammatory demyelinating polyneuropathy, the search for anti-MAG antibodies should be repeated during the course of the neuropathy.
authors.affiliation: Service of Neurology, Hospital Clínic i Provincial de Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Valldeoriola
authors.forename: F
authors.initials: F
authors.lastname: Graus
authors.forename: A J
authors.initials: AJ
authors.lastname: Steck
authors.forename: E
authors.initials: E
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: de la Fuente
authors.forename: T
authors.initials: T
authors.lastname: Gallart
authors.forename: T
authors.initials: T
authors.lastname: Ribalta
authors.forename: J A
authors.initials: JA
authors.lastname: Bombí
authors.forename: E
authors.initials: E
authors.lastname: Tolosa
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D003711:Demyelinating Diseases / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005385:Fingers / Q000294:innervation; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D010265:Paraproteinemias / Q000097:blood / Q000150:complications / Q000276:immunology*; D010292:Paresthesia / Q000097:blood / Q000276:immunology* / Q000503:physiopathology
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein