Interpretive criteria and quality control parameters for testing bacterial susceptibility to the fluoroquinolone PD131628.
For testing bacterial susceptibility to PD131628, a 5-micrograms disk and the following tentative interpretive criteria may be used: > or = 19 mm for susceptible (MIC, < or = 1.0 micrograms/ml), 16 to 18 mm for intermediate (MIC, 2.0 micrograms/ml), and < or = 15 mm for resistant (MIC, > or = 4.0 micrograms/ml). For standard quality control strains, the following limits are proposed: for Escherichia coli ATCC 25922, zones of 31 to 41 mm or a MIC of 0.002 to 0.016 micrograms/ml; for Pseudomonas aeruginosa ATCC 27853, zones of 26 to 34 mm or a MIC of 0.12 to 0.5 micrograms/ml; for Staphylococcus aureus ATCC 25923, zones of 27 to 33 mm; for Staphylococcus aureus ATCC 29213, a MIC of 0.03 to 0.12 micrograms/ml; and for Enterococcus faecalis ATCC 29212, a MIC of 0.12 to 0.5 micrograms/ml.
Barry
A L
AL
Clinical Microbiology Institute, Tualatin, Oregon 97062.
Fuchs
P C
PC
Allen
S D
SD
Tenover
F C
FC
Jorgensen
J H
JH
Reller
L B
LB
D000890:Anti-Infective Agents / Q000494:pharmacology*; D004058:Diffusion; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests / Q000592:standards*; D009287:Naphthyridines / Q000494:pharmacology*; D011355:Prodrugs / Q000494:pharmacology; D011786:Quality Control; D013045:Species Specificity
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C092809:PD 131112; D011355:Prodrugs; C068217:PD 131628