IgA cold agglutinins recognize Pr and Sa antigens expressed on glycophorins.
Three cases of IgA kappa cold agglutinins (CAs) were studied. One had anti-Pr1 specificity, one had anti-Pra, and one had anti-Sa. The CAs recognize O-glycans of glycophorins. The findings supplement previous data on anti-Pr1 specificities of four IgA kappa CAs. Because all IgA kappa CAs described recognize O-glycans of glycophorins, a close association between the CA IgA isotype and specificities for O-glycans becomes apparent. It is unlikely, however, that the striking association reflects interrelations between IgA CA structure and specificity, because anti-Sa specificity and all anti-Pr subspecificities were originally defined with IgM CAs.
Roelcke
D
D
Institute for Immunology, Blood Bank, University of Heidelberg, Germany.
Hack
H
H
Kreft
H
H
MacDonald
B
B
Pereira
A
A
Habibi
B
B
D000328:Adult; D000368:Aged; D000373:Agglutinins / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D002240:Carbohydrate Sequence; D003080:Cold Temperature; D003450:Cryoglobulins; D000939:Epitopes; D004912:Erythrocytes / Q000737:chemistry; D006021:Glycophorins / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007147:Immunoglobulin Light Chains; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data
D000373:Agglutinins; D000888:Antibodies, Anti-Idiotypic; D003450:Cryoglobulins; D000939:Epitopes; D006021:Glycophorins; D007070:Immunoglobulin A; D007147:Immunoglobulin Light Chains; C049937:anti-IgA; C029443:cold agglutinins