title: Topographic analysis of the effects of isoflurane anesthesia on SEP.
abstract: Isoflurane anesthesia induces a striking increase in the P22 potential recorded over the precentral scalp whereas the amplitude of the N20 is reduced. It is not known whether the increased "P22" enhanced by isoflurane arises from the same generator as the small precentral P22 potential recorded in the normal awake subject. Multi-channel recordings of SEP before and during isoflurane anesthesia were performed in 13 normal subjects. Isopotential topographic maps showed that isoflurane did not change the distribution of the precentral "P22" despite its clear amplitude increase. Our data confirm that isoflurane enhances the precentral P22 and that the enhanced "P22" arises from the same generator as the P22 recorded before isoflurane anesthesia.
authors.affiliation: Service de Neurologie, Cliniques Universitaires de Bruxelles, Hôpital Erasme, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Vandesteene
authors.forename: N
authors.initials: N
authors.lastname: Mavroudakis
authors.forename: M
authors.initials: M
authors.lastname: Defevrimont
authors.forename: E
authors.initials: E
authors.lastname: Brunko
authors.forename: D
authors.initials: D
authors.lastname: Zegers de Beyl
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008475:Median Nerve / Q000187:drug effects / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time; D012535:Scalp; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology
chemical_list: D007530:Isoflurane