title: Chondroid syringoma with hyaline cell change.
abstract: Four cases of chondroid syringoma containing large numbers of hyaline or plasmacytoid cells are described. Three cases occurred in the hand and one in the foot. Hyaline cells are commonly seen in mixed tumours and myoepitheliomas of salivary glands and rarely in chondroid syringomas. The hyaline-cell change in three of the cases initially caused diagnostic difficulties and the possibility of sarcoma was raised in two cases. In addition to the characteristic hyaline cells, the presence of tubulo-glandulo-ductal structures, benign squamous epithelium and myxochondroid stroma aided diagnosis. Immunohistochemically, the hyaline cells exhibited positivity for vimentin, cytokeratin, S-100 protein, carcino-embryonic antigen, focal glial fibrillary acidic protein (3 cases), neuron-specific enolase (3 cases) and focal alpha-smooth muscle actin (2 cases). Occasional cells were Ber EP4 positive (2 cases). In some cells, a striking peripheral ring-like positivity for cytokeratin and S-100 protein was noted. Ultrastructurally, desmosomes, varying numbers of tonofibrils and non-bundling intermediate filaments were seen. Scanty fine filaments with vague focal densities were detected in some cells. Our studies suggest that the hyaline cells represent modified epithelial as well as myoepithelial cells. One of our cases also exhibited collagenous spherulosis.
authors.affiliation: Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Banerjee
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: B P
authors.initials: BP
authors.lastname: Eyden
authors.forename: S
authors.initials: S
authors.lastname: Howell
authors.forename: S
authors.initials: S
authors.lastname: Wells
authors.forename: A R
authors.initials: AR
authors.lastname: Mainwaring
mesh_terms: D000199:Actins / Q000032:analysis / Q000378:metabolism; D006607:Adenoma, Sweat Gland / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000378:metabolism; D002356:Cartilage / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D002357:Cartilage Diseases / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000737:chemistry / Q000648:ultrastructure; D007633:Keratins / Q000032:analysis / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000378:metabolism; D009418:S100 Proteins / Q000032:analysis / Q000378:metabolism; D014746:Vimentin / Q000032:analysis / Q000378:metabolism
chemical_list: D000199:Actins; D002272:Carcinoembryonic Antigen; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins; D010751:Phosphopyruvate Hydratase