Development toxicity of fumonisin in Syrian hamsters.
The effects of fumonisin on development of Syrian hamster fetuses were studied using fumonisin B1 and B2 extracted from Fusarium moniliforme corn-culture and purified fumonisin B1. A significant increase in litters with fetal deaths occurred with the high doses of purified (18 mg FB1/kg) and culture-extracted (18 mg FB1 plus 4.5 mg FB2) fumonisin. It is concluded that prenatal exposure to fumonisin on days 8 and 9 of gestation is detrimental to fetal hamster survivability but does not induce clinical maternal intoxication at these doses. Equivalent doses of fumonisin B1, whether from culture-extract or pure solution produced similar results.
Floss
J L
JL
Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia.
Casteel
S W
SW
Johnson
G C
GC
Rottinghaus
G E
GE
Krause
G F
GF
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D001663:Bilirubin / Q000097:blood; D006224:Cricetinae; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D037341:Fumonisins; D005670:Fusarium / Q000472:pathogenicity; D008431:Maternal-Fetal Exchange; D008647:Mesocricetus; D009183:Mycotoxins / Q000302:isolation & purification / Q000633:toxicity*; D011247:Pregnancy
D037341:Fumonisins; D009183:Mycotoxins; C056934:fumonisin B2; C056933:fumonisin B1; D001663:Bilirubin