title: Clozapine-induced agranulocytosis and colony-stimulating cytokines.
abstract: A case of clozapine-induced agranulocytosis that was treated with a granulocyte colony-stimulating cytokine is presented. The hematological status normalized. Two colony-stimulating factors are marketed for activating bone marrow function. Their utility in clozapine a granulocytoses is not clear, but they offer a potential new therapeutic option.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Louisville, School of Medicine, Kentucky.
authors.forename: B M
authors.initials: BM
authors.lastname: Ryabik
authors.forename: V T
authors.initials: VT
authors.lastname: Nguyen
authors.forename: R M
authors.initials: RM
authors.lastname: Mann
authors.forename: J D
authors.initials: JD
authors.lastname: Smith
authors.forename: S B
authors.initials: SB
authors.lastname: Lippmann
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced* / Q000276:immunology / Q000628:therapy; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D011994:Recombinant Proteins / Q000008:administration & dosage; D012559:Schizophrenia / Q000188:drug therapy* / Q000276:immunology
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003024:Clozapine