[An electron radioautographic study of the vessels in the granulation tissue of long-term nonhealing wounds].
The wounds without healing for a long time (from 1 month to 2 years) were studied histologically and electron-radioautographically. The reduction of the vessel number in such wounds occurs, first, due to degenerative changes in the cells of their walls, and second, due to loss of connection between the cells. Some of these cells retain functional activity (incorporation of 3H-uridine) and capacity for proliferation (incorporation of 3H-thymidine). The latter is particularly characteristic for pericytes, this proving their role as a source of fibroblasts in the stage of organization and formation of the scar.
Smol'iannikova
V A
VA
Svetukhin
A M
AM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001345:Autoradiography; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D006097:Granulation Tissue / Q000098:blood supply* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D051381:Rats; D014945:Wound Healing; D014947:Wounds and Injuries / Q000473:pathology*