[Serum anti-hepatitis C virus and hepatitis C virus RNA in patients with hepatocellular carcinoma].
Serum anti-HCV and HCV RNA (RT-PCR), possible association to the markers of hepatitis B virus (HBV-M) including HBsAg were evaluated in 48 patients with hepatocellular carcinoma (HCC). The results indicated that 13 were anti-HCV positive in HCC group and 5 in other cancers (control group, P < 0.05). Serum HCV RNA was detected in 11 patients with HCC (23%). The positive rate of HCV RNA and/or anti-HCV (HCV-M) was 38% in all HCC cases, 80% (12/15) in HBV-M (-) HCC, 58% (14/24) in HBsAg(-), 18% (6/33) in HBV-M(+), and 15% (4/24) in HBsAg(+). HBV-M and/or HCV-M was found positive in 45 patients with HCC (93.8%). Our study shows that both HBV and HCV infections are related to the development of HCC. HCV-M was found positive mostly in HBV-M negative HCC patients and serum HCV RNA replication existed in some of HCC cases.
Jiang
M D
MD
Department of Gastroenterology, General Hospital of Chengdu Command.
D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000382:microbiology*; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006508:Hepatitis Antibodies / Q000097:blood; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification; D018937:Hepatitis C Antibodies; D006801:Humans; D008113:Liver Neoplasms / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis*
D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D012367:RNA, Viral