Inhibitory effects of acetaminophen, 7,8-benzoflavone and methimazole towards N-nitrosodimethylamine mutagenesis in Arabidopsis thaliana.
The metabolic inhibitors acetaminophen, 7,8-benzoflavone, and methimazole significantly reduced the mutagenicity of the promutagen N-nitrosodimethylamine in the higher plant Arabidopsis thaliana. In contrast, these metabolic inhibitors had no effect on the mutagenicity of the direct-acting mutagen N-methyl-N'-nitro-N-nitrosoguanidine.
Gichner
T
T
Institute of Experimental Botany, Prague, Czech Republic.
Velemínský
J
J
Wagner
E D
ED
Plewa
M J
MJ
D000082:Acetaminophen / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics*; D001571:Benzoflavones / Q000494:pharmacology*; D004128:Dimethylnitrosamine / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008713:Methimazole / Q000494:pharmacology*; D016296:Mutagenesis / Q000187:drug effects*; D009153:Mutagens / Q000633:toxicity; D012639:Seeds / Q000187:drug effects / Q000235:genetics; D013053:Spectrophotometry
D016587:Antimutagenic Agents; D001571:Benzoflavones; D009153:Mutagens; D000082:Acetaminophen; D008713:Methimazole; C011512:alpha-naphthoflavone; D004128:Dimethylnitrosamine