title: Primary hepatocellular carcinoma in women of mainland China. A clinicopathologic analysis of 104 patients.
abstract: The clinicopathologic characteristics of 104 hepatectomy samples from female patients with primary hepatocellular carcinoma (PHC) were compared with similar samples from 900 male patients with primary hepatocellular carcinoma; results of this comparison were studied. The male-to-female ratio was 8.7:1. The mean age of female patients with PHC was 46.2 years, which was approximately 3 years younger (49.1 years) than that of male patients with PHC. The frequency of associated liver cirrhosis (LC) was 49% in women with PHC and 68.2% in men with PHC (P < 0.01). The mean age of the female patients without LC was 43.2 years, more than 4 years younger (47.9 years) than that of the male patients. The mean ages of female and male patients with LC were 49.1 years and 49.8 years, 6 and 2 years older than that of their corresponding groups without LC, respectively. The positive rates of serum hepatitis B surface antigen (HBsAg) were 70.8% in the men and 59.7% in the women. The 5-year postoperative survival rates were 50% in the women and 25.7% in the men (P < 0.01). It is suggested that the development of PHC in women appears at a younger age than that of PHC in men in China and usually is associated with a lower frequency of LC and a more satisfactory postoperative prognosis.
authors.affiliation: Institute of Hepatobiliary Surgery, Changhai Hospital, China.
authors.forename: W M
authors.initials: WM
authors.lastname: Cong
authors.forename: M C
authors.initials: MC
authors.lastname: Wu
authors.forename: X H
authors.initials: XH
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: J Y
authors.initials: JY
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000367:Age Factors; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000503:physiopathology; D002681:China; D005260:Female; D006498:Hepatectomy; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D006514:Hepatitis B Surface Antigens; D000509:alpha-Fetoproteins