title: The ups and downs of EAE.
abstract: Experimental allergic encephalomyelitis (EAE) is considered the animal disease model for multiple sclerosis (MS) in humans. However, EAE is an acute disease whereas MS is a chronic disease. The on-off nature in both diseases of autoimmune reactivity suggests a regulatory response by the host, a response which can effect the autoreactive T cell by modulating-up or modulating-down. This review discusses various aspects of this regulation, seen after administration of autoantigen, of antibody directed at the T cell receptor (TcR), and of fragments of the TcR itself.
authors.affiliation: Wistar Institute, Philadelphia, Pennsylvania.
authors.forename: E
authors.initials: E
authors.lastname: Heber-Katz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015536:Down-Regulation / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D015854:Up-Regulation / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D004676:Myelin Basic Protein; D016693:Receptors, Antigen, T-Cell, alpha-beta