Indomethacin reduces substance P levels in human ocular aqueous humor.
Substance P immunoreactivity was measured by radioimmunoassay in aqueous humor samples of patients treated 13 h earlier with gentamicin, indomethacin or timolol. The indomethacin-treated group showed significantly decreased levels of substance P. The indomethacin effect is due to inhibition of the synthesis of arachidonic acid metabolites or involves non-specific mechanisms. It is suggested that suppression of substance P release may contribute to therapeutic effects of indomethacin in the human eye in conditions such as surgical miosis.
Kieselbach
G
G
Department of Ophthalmology, University of Innsbruck, Austria.
Troger
J
J
Kaehler
C
C
Saria
A
A
D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013373:Substance P / Q000378:metabolism*; D013999:Timolol / Q000494:pharmacology
D005839:Gentamicins; D013373:Substance P; D013999:Timolol; D007213:Indomethacin