title: Influence of four diets containing approximately 11% protein (dry weight) on uric acid, sodium urate, and ammonium urate urine activity product ratios of healthy beagles.
abstract: Urine activity product ratios of uric acid (APRua), sodium urate (APRna), and ammonium urate (APRau), and urinary excretion of 10 metabolites were determined in 24-hour urine samples produced by 6 healthy Beagles during periods of consumption of 4 diets containing approximately 11% protein (dry weight) and various protein sources: a 72% moisture, casein-based diet; a 10% moisture, egg-based diet; a 72% moisture, chicken-based diet; and a 71% moisture, chicken-based, liver-flavored diet. Significantly (P < 0.05) higher APRua, APRna, and APRau were observed when dogs consumed the egg-based diet, compared with the other 3 diets; there were no differences in these ratios among the other 3 diets. Twenty-four-hour urinary excretions of chloride, potassium, phosphorus, and oxalic acid were significantly (P < 0.05) higher when dogs consumed the egg-based diet. Twenty-four-hour urinary excretions of sodium were significantly (P < 0.05) higher when dogs consumed the egg-based diet, compared with the casein-based diet and the chicken-based, liver-flavored diet, but were not significantly different between the egg-based diet and chicken-based diet. Twenty-four-hour urine volume was similar when dogs consumed the 4 diets. Twenty-four-hour endogenous creatinine clearance was significantly (P < 0.05) lower when dogs consumed the casein-based diet; there were no differences among the other 3 diets. Although consumption of all diets was associated with production of alkaline urine, the 24-hour urine pH was significantly (P < 0.05) higher when dogs consumed the egg-based diet.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
authors.forename: J W
authors.initials: JW
authors.lastname: Bartges
authors.forename: C A
authors.initials: CA
authors.lastname: Osborne
authors.forename: L J
authors.initials: LJ
authors.lastname: Felice
authors.forename: T A
authors.initials: TA
authors.lastname: Allen
authors.forename: C
authors.initials: C
authors.lastname: Brown
authors.forename: L A
authors.initials: LA
authors.lastname: Koehler
authors.forename: K A
authors.initials: KA
authors.lastname: Bird
authors.forename: L K
authors.initials: LK
authors.lastname: Unger
authors.forename: M
authors.initials: M
authors.lastname: Chen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage*; D004283:Dog Diseases / Q000517:prevention & control; D004285:Dogs / Q000097:blood / Q000652:urine*; D005260:Female; D014527:Uric Acid / Q000652:urine*; D014545:Urinary Calculi / Q000517:prevention & control / Q000662:veterinary
chemical_list: D004044:Dietary Proteins; D014527:Uric Acid