Selective delivery of pepleomycin to esophageal lymph nodes by activated carbon particles.
Selective delivery of a high dose of pepleomycin (PEP) to regional nodes of the esophagus was studied using PEP adsorbed on activated carbon particles (PEP-C) and PEP lipiodol emulsion (PEP-L). PEP-C trans-endoscopically injected into the canine esophageal wall was preferentially retained there for over 7 days and was gradually delivered at a much higher and selective level to 83% of regional nodes, both proximal and distal, for over 7 days, with a much lower level of PEP in the whole body, in comparison with PEP-L and PEP solution.
Hirao
E
E
Department of Surgery I, Oita Medical University, Japan.
Saito
T
T
Kobayashi
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001761:Bleomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002244:Carbon; D004285:Dogs; D004337:Drug Carriers; D004655:Emulsions; D004947:Esophagus / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism*; D008297:Male; D017663:Peplomycin; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D004655:Emulsions; D001761:Bleomycin; D017663:Peplomycin; D002244:Carbon