Role of 5-hydroxytryptamine in toxaemia of pregnancy.
5-HT concentration in blood of 24 randomly selected pregnant women presenting with signs and symptoms of toxaemia of pregnancy were estimated and compared with 30 normal pregnant women. As such 5-HT level increases with the progress of pregnancy and in toxaemia group in comparison to normal pregnancy. A change in the degree of oedema from moderate to severe could bring a statistically significant change in blood pressure and serum 5-HT level. Increased 5-HT plays a role in toxaemia as well as in normal pregnancy and some of the toxic effects observed in toxaemia of pregnancy are due to the effects of 5-HT.
Bhattacharyya
T K
TK
Department of Pharmacology, School of Tropical Medicine, Calcutta.
Debnath
P K
PK
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D004487:Edema / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology* / Q000378:metabolism; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012701:Serotonin / Q000097:blood / Q000502:physiology*
D012701:Serotonin