title: Hypothalamic dysfunction in a child: a distinct syndrome? Report of a case and review of the literature.
abstract: We report the case of a 9-year-old girl with multiple problems due to hypothalamic dysfunction of obscure origin: apnoeic spells, behavioural problems, developmental delay, hypodipsia with bouts of hypernatraemia, episodes of spontaneous hypothermia, obesity, petit-mal seizures, non-progressive precocious puberty, absence of respiratory response to CO2 and probably insensitivity of hyposensitivity to pain. She also had hyperprolactinaemia and decreased human growth hormone secretion. Hypothyroidism of central origin and hyposecretion of cortisol were also present. Multiple brain CT-scans failed to reveal any tumour or other anatomical abnormality. Her clinical course was improved initially by treatment with clomipramine, but she died suddenly, and the autopsy failed to disclose any anatomical lesion. We compare this case with three similar previously reported cases.
authors.affiliation: Department of Paediatrics, Hôpital Sainte-Justine, Université de Montréal, Québec, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Proulx
authors.forename: M L
authors.initials: ML
authors.lastname: Weber
authors.forename: R
authors.initials: R
authors.lastname: Collu
authors.forename: M
authors.initials: M
authors.lastname: Lelièvre
authors.forename: A
authors.initials: A
authors.lastname: Larbrisseau
authors.forename: M
authors.initials: M
authors.lastname: Delisle
mesh_terms: D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology; D002658:Developmental Disabilities / Q000209:etiology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D013577:Syndrome
chemical_list: D013006:Growth Hormone