Cerebral microcirculatory disturbances of stroke prone spontaneously hypertensive rats with acute stroke and mechanism of treatment.
Cerebral microcirculatory behavior of stroke prone spontaneously hypertensive rats (SHRSP) suffering from acute stroke (WKY as control group) was studied with laser Doppler flowmetry in vivo. The pharmacological effects of Dextran 40, nimodipine and the combined use of both drugs (40:1 volume ratio) on cerebral microvessels were measured. The results of the experiment have shown that SHRSP had a serious cerebral microcirculatory disturbance when the acute stroke occurred. Both Dextran 40 and nimodipine could improve the cerebral microcirculatory disturbance, but the combined usage presented far more satisfactory effects. Hopefully it will decrease the mortality of patients with acute stroke.
Zhai
Q H
QH
Institute of Microcirculation, Chinese Academy of Medical Sciences, Beijing.
Duan
C G
CG
D000818:Animals; D000252:Calcium-Transporting ATPases; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology; D003911:Dextrans / Q000008:administration & dosage* / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D017078:Laser-Doppler Flowmetry; D009553:Nimodipine / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D003911:Dextrans; D009553:Nimodipine; D000252:Calcium-Transporting ATPases