title: Complete sequence of a hair-like intermediate filament type II keratin gene.
abstract: The Intermediate Filament (IF) superfamily comprises several multigene families, of which the two keratin families are the largest. The keratin IF genes are expressed in epithelial tissues in differentiation-specific patterns and recently we reported the sequence and expression of a hair IF type II keratin gene (KRT2.9). Two related genes were present in the cosmid containing KRT2.9 and we have now sequenced one of them and found that it encodes a hair-like IF type II protein (KRT2.13). However, KRT2.13 is not expressed in the hair follicle. Interestingly there is significant sequence homology between introns 1, 5 and 6 of KRT2.13 and KRT2.9 to suggest gene conversion of these regions or possibly conservation of functional sequences.
authors.affiliation: Department of Biochemistry, University of Adelaide, South Australia.
authors.forename: B C
authors.initials: BC
authors.lastname: Powell
authors.forename: L A
authors.initials: LA
authors.lastname: Crocker
authors.forename: G E
authors.initials: GE
authors.lastname: Rogers
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D006197:Hair; D007633:Keratins / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: C084341:K2.13 protein, Ovis aries; D007633:Keratins