title: Methemoglobin reductase deficiency in a cat.
abstract: During ovariohysterectomy of a 6-month-old domestic shorthair cat, extravasated blood appeared brown. Methemoglobinemia was considered likely on the basis of discoloration of oxygenated blood. The absence of clinical signs of toxicosis, inability to identify a source of oxidant that could cause methemoglobinemia, and persistence of cyanotic-appearing tongue and mucous membranes in this cat made a drug-induced cause unlikely, and was suggestive of a congenital disorder. Subsequent analysis revealed 49.6% methemoglobin (normal, 0 to 1.1%), resulting from erythrocyte methemoglobin reductase deficiency (21% of normal activity).
authors.affiliation: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
authors.forename: J W
authors.initials: JW
authors.lastname: Harvey
authors.forename: M
authors.initials: M
authors.lastname: Dahl
authors.forename: M E
authors.initials: ME
authors.lastname: High
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000151:congenital / Q000201:enzymology; D002415:Cats; D042966:Cytochrome-B(5) Reductase / Q000097:blood / Q000172:deficiency*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D008708:Methemoglobinemia / Q000151:congenital / Q000201:enzymology / Q000662:veterinary*
chemical_list: D042966:Cytochrome-B(5) Reductase