Synthesis of 9E- and 9Z-locked retinoic acid analogs as ligands for RAR and RXR.
New retinoic acid (RA) analogs 9E-locked-RA 3 and 9Z-locked-RA 4 were synthesized from dithiane 6 and beta-cyclocitral 13, respectively. Both analogs behaved as agonistic ligands for a mixture of retinoic acid receptor (RAR) and retinoid X receptor (RXR).
Katsuta
Y
Y
Kobe Pharmaceutical University, Japan.
Aoyama
Y
Y
Osone
H
H
Wada
A
A
Uchiyama
S
S
Kitamoto
T
T
Masushige
S
S
Kato
S
S
Ito
M
M
D015500:Chloramphenicol O-Acetyltransferase / Q000096:biosynthesis; D002851:Chromatography, High Pressure Liquid; D018168:Receptors, Retinoic Acid / Q000819:agonists*; D047488:Retinoid X Receptors; D014157:Transcription Factors / Q000819:agonists*; D014158:Transcription, Genetic / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology*
D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D014157:Transcription Factors; D014212:Tretinoin; D015500:Chloramphenicol O-Acetyltransferase