title: Tandem time-of-flight mass spectrometer.
abstract: A compact, laser desorption tandem time-of-flight mass spectrometer is described. The instrument incorporates two dual-stage reflectron analyzers and a collision region for producing product ions by collision-induced dissociation. Selection of ions of a particular mass is accomplished by deflection of ions from stable trajectory angles entering the second reflectron, while the use of a pulsed valve for introduction of the collision gas obviates the need for differential pumping of the collision region. Initial results are presented, as well as a discussion for optimizing the performance of tandem time-of-flight instruments.
authors.affiliation: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
authors.forename: T J
authors.initials: TJ
authors.lastname: Cornish
authors.forename: R J
authors.initials: RJ
authors.lastname: Cotter
mesh_terms: D003373:Coumaric Acids / Q000032:analysis; D006096:Gramicidin / Q000032:analysis; D013058:Mass Spectrometry / Q000295:instrumentation*; D012235:Rhodamines / Q000032:analysis
chemical_list: D003373:Coumaric Acids; D012235:Rhodamines; D006096:Gramicidin; C007175:alpha-cyano-4-hydroxycinnamate