title: "Goal-directed" transfusion management leads to distinct reduction of fluid requirement in liver transplantation.
abstract: Complications in patients undergoing OLT, such as hemorrhagic events, are caused not only by surgical problems but also by the profound functional disturbances arising from hepatic insufficiency, which are at least partially cured by the procedure itself. Preoperative clotting data give insight only into the dysfunction of the explanted organ. Hence, we tried to perform a standardized, "goal-directed" anesthesiologic management in the perioperative phase in OLT, following strict indications for blood replacement according to diuresis, hemoglobin level, and hemodynamic parameters. We performed 200 OLTs in 185 patients, according to usual methods. The mean intraoperative fluid requirement was 884 ml of balanced salt solution, 8.1 units of RBC, and 9.4 units of FFP. During the first 24 hours postoperatively, an average of 2.4 units of RBC and 5.6 units of FFP had to be transfused. Currently, 170 of the 185 patients (91.9%) are alive and well. Our data demonstrate that a distinct reduction of transfusion rates in OLT is possible, neglecting clotting data and improving clotting function by avoiding hemodilution.
authors.affiliation: Clinic for Anesthesiology & Intensive Care Medicine, University Clinic Rudolf Virchow, Free University of Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Gerlach
authors.forename: R
authors.initials: R
authors.lastname: Rossaint
authors.forename: W O
authors.initials: WO
authors.lastname: Bechstein
authors.forename: G
authors.initials: G
authors.lastname: Blumhardt
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
authors.forename: K
authors.initials: K
authors.lastname: Falke
mesh_terms: D007611:Aprotinin / Q000008:administration & dosage / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000503:physiopathology; D001780:Blood Coagulation Tests; D016913:Blood Component Transfusion / Q000706:statistics & numerical data*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion / Q000706:statistics & numerical data / Q000639:trends; D017707:Erythrocyte Transfusion; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous; D008107:Liver Diseases / Q000097:blood / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D010949:Plasma; D015996:Survival Rate
chemical_list: D007611:Aprotinin