Does transurethral thermotherapy induce a long-term alpha blockade? An immunohistochemical study.
10 patients underwent transurethral thermotherapy and after few days were submitted to open prostatectomy. The surgical specimens were compared to those of 2 other patients used as controls. Pathological specimens were evaluated using histological and immunohistochemical stains. Microscopic examination showed a well-preserved urethra and microabscesses, epithelial necrosis and vasculitis in the prostatic tissue at a depth of 0.5-2 cm from the urethral lumen. Immunohistochemical stains showed the damage and disappearance of nervous fibers.
Perachino
M
M
Department of Urology, S. Corona Hospital, Pietra Ligure, Italy.
Bozzo
W
W
Puppo
P
P
Vitali
A
A
Ardoino
S
S
Ferro
M A
MA
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D006979:Hyperthermia, Induced; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000628:therapy*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism; D014521:Urethra / Q000294:innervation / Q000473:pathology
D011943:Receptors, Adrenergic, beta