title: Colorectal cancer in patients with ulcerative colitis. A prospective cohort study in Italy.
abstract: BACKGROUND
  The aim of this study was to assess the development of dysplasia or cancer in patients with ulcerative colitis and to determine the effectiveness of colonoscopy and biopsy follow-up in colon cancer surveillance.
  
  
  METHODS
  From 1980 to 1986, 65 patients who had ulcerative colitis for 7 years or more participated in a surveillance program of colonoscopy and biopsy. This cohort was followed until December 1992. Forty-nine patients (75.4%) had extensive colitis and 16 (24.6%) left-sided colitis. The mean disease duration was 17.2 years. Three hundred four colonoscopies were performed. During each endoscopy, random biopsies were performed.
  
  
  RESULTS
  Seven patients had definite dysplasia of the colorectal mucosa. Four of them had high grade lesions and underwent surgery. In all of these patients, colon cancer (3 Dukes' Stage A, 1 Dukes' Stage B) was found. No cancer was found in the other patients. Pedunculated adenomas were excised from 6 other patients during colonoscopy. When dysplasia was diagnosed, these patients were older than those who were dysplasia free, whereas the age at onset of colitis was significantly higher in the former (P < 0.01). Fifteen patients discontinued follow-up. Two of them developed colon cancer diagnosed at an advanced stage.
  
  
  CONCLUSIONS
  Dysplasia, especially of high grade, is a marker of colon cancer risk in patients with longstanding ulcerative colitis. Intensive colonoscopy and biopsy surveillance can lead to the diagnosis of colon cancer at a potentially curable stage. In this series, older age appeared to be an additional risk factor. A careful selection of patients with ulcerative colitis seems mandatory to minimize the cost and optimize the benefit of colon cancer surveillance programs.
authors.affiliation: Istituto di Clinica Medica e Gastroenterologia, University of Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Biasco
authors.forename: G
authors.initials: G
authors.lastname: Brandi
authors.forename: G M
authors.initials: GM
authors.lastname: Paganelli
authors.forename: F P
authors.initials: FP
authors.lastname: Rossini
authors.forename: R
authors.initials: R
authors.lastname: Santucci
authors.forename: G
authors.initials: G
authors.lastname: Di Febo
authors.forename: M
authors.initials: M
authors.lastname: Miglioli
authors.forename: M
authors.initials: M
authors.lastname: Risio
authors.forename: A M
authors.initials: AM
authors.lastname: Morselli Labate
authors.forename: L
authors.initials: L
authors.lastname: Barbara
mesh_terms: D000328:Adult; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000473:pathology* / Q000503:physiopathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged