[Fetal arrhythmias--new immunologic studies and results].
The etiology of fetal arrhythmias is still unknown. We therefore did a research for immunologic causes: antimyolemmal antibodies (AMLA) in mothers and umbilical cord serum resulting from secondary immunopathogenesis caused by myocarditis of the mother. Is there a correlation between immunological and clinical findings giving a possible explanation for fetal arrhythmias? In 21 cases mothers and umbilical cord serum was investigated for AMLA; 16 with fetal atrial premature beats, 4 with fetal tachycardia and 1 with fetal bradyarrhythmia. From 16 mothers with fetal atrial premature beats had 12 AMLA, from these were in 4 cases in the umbilical cord serum AMLA. In 4 cases of fetal tachycardia we found in 1 case AMLA in mothers and umbilical cord serum. In the other 3 cases accessory pathways have been the cause for tachycardia. From 19 healthy persons were found in 3 cases AMLA in mothers serum, umbilical cord serum was negative.
Wedeking-Schöhl
H
H
Frauenklinik der Medizinischen Hochschule Hannover.
Maisch
B
B
Schönian
U H
UH
D000914:Antibodies, Viral / Q000032:analysis; D001145:Arrhythmias, Cardiac / Q000151:congenital* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001919:Bradycardia / Q000151:congenital / Q000276:immunology; D005117:Cardiac Complexes, Premature / Q000151:congenital / Q000276:immunology; D004452:Echocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009205:Myocarditis / Q000276:immunology; D009206:Myocardium / Q000276:immunology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000276:immunology; D013610:Tachycardia / Q000151:congenital / Q000276:immunology; D013617:Tachycardia, Supraventricular / Q000151:congenital / Q000276:immunology; D016216:Ultrasonography, Prenatal
D000914:Antibodies, Viral; D001323:Autoantibodies