Repeated treatment with fluoxetine decreases the number of spontaneously active cells per track in frontal cortex.
Repeated (10 mg/kg i.p. x 14 days, once daily), but not acute (10 and 40 mg/kg i.p., 30 min), treatment with fluoxetine decreased the number of active neurons in the frontal cortex 30 min (-55%) or 24 h (-62%) after the last drug injection. This result supports the view that repeated, but not acute, treatment with fluoxetine decreases the function of the frontal cortex.
Ceci
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Department of Pharmacology, Boehringer Ingelheim Italia, Milan.
Fodritto
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Borsini
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004594:Electrophysiology; D005473:Fluoxetine / Q000494:pharmacology*; D005625:Frontal Lobe / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D005473:Fluoxetine