title: Early determination of neurological outcome after prehospital cardiopulmonary resuscitation.
abstract: OBJECTIVE
  Although there are various methods of determining neurological prognosis after cardiopulmonary resuscitation, the final outcome of patients often remains unclear for quite a long time.
  
  
  METHODS
  We investigated 30 consecutively admitted patients who had been successfully resuscitated by the team of the local mobile intensive care unit after cardiac arrest. Determinations of the period of anoxia and of the cardiopulmonary resuscitation time, clinical investigation, echocardiography, electroencephalography, evoked potentials, magnetic resonance imaging, and magnetic resonance spectroscopy were performed.
  
  
  RESULTS
  Demonstration of brain lactate in proton magnetic resonance spectroscopy (P < .01) and absent N20 waves in short-latency somatosensory evoked potentials (P < .01) proved to be significant in terms of a poor prognosis. Correlations between both duration of anoxia and cardiopulmonary resuscitation time and neurological outcome could be shown as well (both P < .05).
  
  
  CONCLUSIONS
  Proton magnetic resonance spectroscopy and short-latency evoked potentials are of great benefit in the prognostic evaluation after cardiopulmonary resuscitation.
authors.affiliation: Department of Neurology, University Hospital Innsbruck, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Berek
authors.forename: P
authors.initials: P
authors.lastname: Lechleitner
authors.forename: G
authors.initials: G
authors.lastname: Luef
authors.forename: S
authors.initials: S
authors.lastname: Felber
authors.forename: L
authors.initials: L
authors.lastname: Saltuari
authors.forename: A
authors.initials: A
authors.lastname: Schinnerl
authors.forename: C
authors.initials: C
authors.lastname: Traweger
authors.forename: F
authors.initials: F
authors.lastname: Dienstl
authors.forename: F
authors.initials: F
authors.lastname: Aichner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D016887:Cardiopulmonary Resuscitation; D004594:Electrophysiology; D005260:Female; D006323:Heart Arrest / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007773:Lactates / Q000032:analysis; D019344:Lactic Acid; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011379:Prognosis
chemical_list: D007773:Lactates; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate