title: Near-haploid karyotype in a squamous cell lung carcinoma.
abstract: Cytogenetic analysis of a squamous cell lung carcinoma revealed a near-haploid karyotype with 27 chromosomes, in both primary cultures and an established cell line. The only chromosomes with two homologs present were chromosomes X, 5, 7, and 22. The two X chromosomes were early and late replicating, respectively. No structural rearrangements could be detected. In vitro, the clone evolved by duplication towards hyperdiploidy with 54 chromosomes.
authors.affiliation: Laboratoire de Biologie de la Fertilité et de Cytogénétique, Hôtel-Dieu, Hôpital Laennec, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Drouin
authors.forename: F
authors.initials: F
authors.lastname: Viguié
authors.forename: B
authors.initials: B
authors.lastname: Debesse
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002871:Chromosome Banding; D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics*; D008875:Middle Aged; D014407:Tumor Cells, Cultured