Salivary gland involvement in Wegener's granulomatosis. A case report and review of the literature.
Late involvement of the parotid gland in a patient with a limited form of Wegener's granulomatosis is presented. We report the full course of the disease and the difficulties encountered in determining the nature of the parotid enlargement. We discuss the contribution of computerized tomography and ultrasonography to elucidate parenchymal morphologic findings and radioisotope studies to determine the functional capacity of the gland. In cases of Wegener's granulomatosis with salivary symptoms, measurement of salivary gland functional capacity, in addition to the c-ANCA test, may help to monitor disease activity. Despite the rarity of the disease, in cases when granulomatous diseases are considered, it should be recognized that Wegener's granulomatosis may result in salivary gland involvement.
Lustmann
J
J
Department of Oral and Maxillofacial Surgery, Hebrew University-Hadassah, School of Dental Medicine, Jerusalem, Israel.
Segal
N
N
Markitziu
A
A
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D010305:Parotid Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D010306:Parotid Gland / Q000503:physiopathology; D011241:Prednisone / Q000627:therapeutic use; D017263:Technetium Tc 99m Mertiatide; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014463:Ultrasonography
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; D017263:Technetium Tc 99m Mertiatide; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003520:Cyclophosphamide; D011241:Prednisone