title: mtDNA variation of aboriginal Siberians reveals distinct genetic affinities with Native Americans.
abstract: The mtDNA variation of 411 individuals from 10 aboriginal Siberian populations was analyzed in an effort to delineate the relationships between Siberian and Native American populations. All mtDNAs were characterized by PCR amplification and restriction analysis, and a subset of them was characterized by control region sequencing. The resulting data were then compiled with previous mtDNA data from Native Americans and Asians and were used for phylogenetic analyses and sequence divergence estimations. Aboriginal Siberian populations exhibited mtDNAs from three (A, C, and D) of the four haplogroups observed in Native Americans. However, none of the Siberian populations showed mtDNAs from the fourth haplogroup, group B. The presence of group B deletion haplotypes in East Asian and Native American populations but their absence in Siberians raises the possibility that haplogroup B could represent a migratory event distinct from the one(s) which brought group A, C, and D mtDNAs to the Americas. Our findings support the hypothesis that the first humans to move from Siberia to the Americas carried with them a limited number of founding mtDNAs and that the initial migration occurred between 17,000-34,000 years before present.
authors.affiliation: Department of Genetics and Molecular Medicine, Emory University, Atlanta, GA 30322.
authors.forename: A
authors.initials: A
authors.lastname: Torroni
authors.forename: R I
authors.initials: RI
authors.lastname: Sukernik
authors.forename: T G
authors.initials: TG
authors.lastname: Schurr
authors.forename: Y B
authors.initials: YB
authors.lastname: Starikorskaya
authors.forename: M F
authors.initials: MF
authors.lastname: Cabell
authors.forename: M H
authors.initials: MH
authors.lastname: Crawford
authors.forename: A G
authors.initials: AG
authors.lastname: Comuzzie
authors.forename: D C
authors.initials: DC
authors.lastname: Wallace
mesh_terms: D000569:Americas; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D016172:DNA Fingerprinting; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007197:Indians, Central American / Q000235:genetics; D007198:Indians, North American / Q000235:genetics*; D007199:Indians, South American / Q000235:genetics; D004930:Inuit / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D012800:Siberia; D013997:Time Factors
chemical_list: D004272:DNA, Mitochondrial