title: Antigenic sites on type 2 poliovirus.
abstract: Monoclonal escape variants isolated from the Sabin strain of type 2 poliovirus were examined. Mutations were identified in regions known to be antigenic in other serotypes, although the extent to which they were linked by common antibodies varied. One complex site involved regions of VP2 and VP3 which were not linked in early studies, but have recently been shown by others to be linked in type 1.
authors.affiliation: National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom.
authors.forename: V
authors.initials: V
authors.lastname: Patel
authors.forename: M
authors.initials: M
authors.lastname: Ferguson
authors.forename: P D
authors.initials: PD
authors.lastname: Minor
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D002213:Capsid / Q000235:genetics / Q000276:immunology*; D036022:Capsid Proteins; D000939:Epitopes; D009154:Mutation; D011055:Poliovirus Vaccine, Oral / Q000235:genetics / Q000276:immunology*; D013329:Structure-Activity Relationship
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D000939:Epitopes; D011055:Poliovirus Vaccine, Oral; C442541:VP2 protein, Poliovirus; C442542:VP3 protein, Poliovirus