Testosterone regulates galanin gene expression in the bed nucleus of the stria terminalis.
The regulation of galanin (GAL) gene expression in the bed nucleus of the stria terminalis (BNST) by testosterone (T) was investigated using in situ hybridization histochemistry. Castration of adult male rats significantly reduced both the number of cells which expressed GAL mRNA and the average number of grains per cell. These effects were reversed by testosterone treatment. Testosterone stimulates GAL gene expression in the same neurons that have previously been shown to exhibit steroid regulation of vasopressin gene expression.
Miller
M A
MA
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195.
Kolb
P E
PE
Raskind
M A
MA
D000818:Animals; D019004:Galanin; D005786:Gene Expression Regulation / Q000187:drug effects; D017403:In Situ Hybridization; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009479:Neuropeptides / Q000096:biosynthesis*; D009919:Orchiectomy; D010452:Peptide Biosynthesis; D010455:Peptides / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012826:Silicone Elastomers; D013739:Testosterone / Q000494:pharmacology*; D013787:Thalamic Nuclei / Q000187:drug effects / Q000378:metabolism*
D009479:Neuropeptides; D010455:Peptides; D012826:Silicone Elastomers; D013739:Testosterone; D019004:Galanin