Antigenicity and immunogenicity of antigenized antibodies. Studies on B and T cells.
This laboratory has been testing the possibility of using the complementarity-determining region (CDR) loops of the antibody molecule to express oligopeptide epitopes in an immunologically-accessible and conformationally-suitable way. The new process consists in grafting peptides epitopes derived from antigens other than immunoglobulins into antibody CDR loops. This process, "antibody antigenization," utilizes the immunoglobulin fold as a scaffold to immobilize and present oligopeptide epitopes to the immune system as the integral part of the immunoglobulin molecule. Here we describe some of the initial results with antigenized antibodies (AgAbs).
Billetta
R
R
Department of Medicine and Cancer Center, University of California, San Diego 92093-0961.
Zanetti
M
M
D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology*; D000939:Epitopes / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D011487:Protein Conformation; D013601:T-Lymphocytes / Q000276:immunology*
D000906:Antibodies; D000939:Epitopes