From white spots to stem cells: the role of the Kit receptor in mammalian development.
The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.
Fleischman
R A
RA
Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235-8852.
D000818:Animals; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006801:Humans; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D019009:Proto-Oncogene Proteins c-kit; D016184:Receptors, Colony-Stimulating Factor / Q000235:genetics / Q000502:physiology*; D019089:Stem Cell Factor; D013234:Stem Cells / Q000502:physiology
D016298:Hematopoietic Cell Growth Factors; D011518:Proto-Oncogene Proteins; D016184:Receptors, Colony-Stimulating Factor; D019089:Stem Cell Factor; D011505:Protein-Tyrosine Kinases; D019009:Proto-Oncogene Proteins c-kit