[The effect of 764-3 on alveolar macrophage morphologic changes induced by BLM-A6].
The morphologic changes of alveolar macrophages (AM) were observed by electron microscopy, computer controlled image analysis and stereoscopy. The results showed that 764-3 had no effect on normal AM morphology and structure, but inhibited the BLM-A6 induced increase of volume, specific surface, and lysosome volume density of AM. At the same time, the spreading ability of AM on the slide was markedly reduced by 764-3, indicating that 764-3 can partially prevent the AM activation caused by BLM-A6 in vitro.
Chi
S
S
Institute of Basic Medical Sciences, Beijing.
Yan
Y
Y
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001761:Bleomycin / Q000037:antagonists & inhibitors* / Q000031:analogs & derivatives; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007091:Image Processing, Computer-Assisted; D016676:Macrophages, Alveolar / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C079053:IH 764-3; C052656:bleomycin A6; D001761:Bleomycin