[Somatomedin-C in infantile nutritional assessment with comparison with prealbumin, insulin and growth hormone].
Somatomedin-C (Sm-C) is also called insulin like growth factor I (IGF-I). It has insulin-like biological effects and serves as an anabolism-related mediator of growth hormone. Most Sm-C is synthesized in liver cells. There are decreased blood levels of Sm-C, prealbumin and insulin, but increased blood levels of growth hormone in the adult with malnutrition. We simultaneously measured the blood levels of the above four peptides in infants aged one month to one year. They were divided into four groups: normal, first class malnutrition, second class malnutrition and third class malnutrition. They were classified according to the Value of Nutrition Index. The utility of Sm-C measurement was compared to that of the measurements of prealbumin, insulin and growth hormone in the nutritional assessment. The results revealed that the blood level of Sm-C decreased more in the cases of severe malnutrition (Normal group: male 361.2 +/- 158.9 mU/ml (n = 18), female 499.3 +/- 227.8 mU/ml; (n = 19); First class malnutrition group: 256.9 +/- 81.1 mUU/ml (n = 17); Second class malnutrition group: 169.5 +/- 43.5 mU/ml (n = 15); And third class malnutrition group: 76.2 +/- 26.5 mU/ml (n = 18)). The blood level of prealbumin decreased more in the cases of severe malnutrition (Normal group: 17.8 +/- 2.1 mg/dl (n = 37); First class malnutrition: 11.8 +/- 3.5 mg/dl (n = 17); Second class malnutrition: 11.8 +/- 3.5 mg/dl (n = 15); And third class malnutrition: 9.7 +/- 2.4 mg/dl (n = 18)).(ABSTRACT TRUNCATED AT 250 WORDS)
Dai
Z K
ZK
Department of Pediatrics, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China.
Huang
M Y
MY
Huang
T Y
TY
D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007328:Insulin / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D015596:Nutrition Assessment; D011228:Prealbumin / Q000032:analysis*; D012737:Sex Factors
D007328:Insulin; D011228:Prealbumin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone