title: Long-term effects of amygdaloid kindling on striatal dopaminergic terminals.
abstract: The present study assessed the effects of kindling on striatal DA terminals. Kindled and control rats were tested for DA transporter density using [3H]GBR-12935 binding to striatal membranes and for amphetamine and KCl-induced [3H]DA release from striatal slices. Kindling decreased the maximal number of [3H]GBR-12935 binding sites in the dorsal striatum of rats sacrificed either 2 h or 4 weeks after the last seizure but had no effect on stimulated fractional [3H]DA release. These findings suggest a minor damage to DA terminals in the dorsal striatum. At the same postseizure time points, kindling augmented the hyperlocomotion associated with novel environment. Explanation of this effect requires in vivo measures of striatal DA functioning.
authors.affiliation: Department of Psychology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Gordon
authors.forename: M
authors.initials: M
authors.lastname: Mintz
authors.forename: E
authors.initials: E
authors.lastname: Rosenne
authors.forename: M
authors.initials: M
authors.lastname: Rehavi
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D050483:Dopamine Plasma Membrane Transport Proteins; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009411:Nerve Endings / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D004298:Dopamine