title: Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection.
abstract: Patients who have undergone gastric resection are at higher risk of developing gastric carcinoma than normal subjects, and bile reflux is believed to play a role in carcinogenesis. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging, particularly where there is chronic epithelial injury associated with bile reflux. Helicobacter pylori is considered a major risk factor for gastric cancer in the intact stomach. It has been shown previously that antral cell proliferation is increased in H pylori gastritis and falls to normal levels after eradication of the organism. Little is known of corpus cell proliferation in H pylori gastritis or after gastric resection. Using in vitro bromodeoxyuridine labelling of endoscopic biopsy specimens we have found that corpus cell proliferation is increased in H pylori gastritis. Cell proliferation was greater in corpus biopsy specimens of resected stomachs than in H pylori gastritis. Subgroup analysis of patients who had undergone gastric resection indicated that those positive for H pylori had higher levels of cell proliferation than those negative for the organism. These findings provide further evidence that H pylori and bile have a role in gastric carcinogenesis and suggest that their presence has a synergistic effect on gastric epithelial cell proliferation.
authors.affiliation: Centre for Digestive Diseases, General Infirmary at Leeds.
authors.forename: D A
authors.initials: DA
authors.lastname: Lynch
authors.forename: N P
authors.initials: NP
authors.lastname: Mapstone
authors.forename: A M
authors.initials: AM
authors.lastname: Clarke
authors.forename: P
authors.initials: P
authors.lastname: Jackson
authors.forename: M F
authors.initials: MF
authors.lastname: Dixon
authors.forename: P
authors.initials: P
authors.lastname: Quirke
authors.forename: A T
authors.initials: AT
authors.lastname: Axon
mesh_terms: D000328:Adult; D001655:Bile Reflux / Q000473:pathology; D001973:Bromodeoxyuridine; D002452:Cell Count; D002455:Cell Division; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011184:Postoperative Period; D013270:Stomach / Q000473:pathology* / Q000601:surgery
chemical_list: D001973:Bromodeoxyuridine