Multiple sclerosis: remyelination in acute lesions.
Central nervous system (CNS) remyelination has been found by light and electron microscopy and immunocytochemistry within fresh lesions from four cases of acute and chronic progressive multiple sclerosis (MS). The remyelination was sparse and existed in an edematous parenchyma containing oligodendrocytes, macrophages, hypertrophic astrocytes and inflammatory components, but no fibrillary astrogliosis. It is suggested that this type of CNS remyelination in MS is a transient event. Possible underlying factors are discussed.
Raine
C S
CS
Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, New York 10461.
Wu
E
E
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis; D018959:CD57 Antigens; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009186:Myelin Sheath / Q000737:chemistry / Q000473:pathology*; D009836:Oligodendroglia / Q000737:chemistry / Q000473:pathology
D000943:Antigens, Differentiation; D018959:CD57 Antigens