Involvement of nitric oxide in long-term potentiation in the dentate gyrus in vivo.
Effects of NO synthase inhibitors on long-term potentiation (LTP) were investigated in the dentate gyrus of anesthetized rats. Administration of NG-nitro-L-arginine methyl ester (L-NAME; 50 nmol i.c.v.) greatly blocked the generation of LTP without affecting basal responses. NG-nitro-L-arginine (50 nmol) or NG-methyl-L-arginine (50 nmol) also showed similar effects. The LTP-blocking effect of L-NAME was reversed by coadministration of L-arginine (500 nmol). These results suggest that NO participates in the generation of LTP at the dentate gyrus in vivo.
Mizutani
A
A
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Saito
H
H
Abe
K
K
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D051381:Rats; D011919:Rats, Inbred Strains; D019323:omega-N-Methylarginine
D019335:Nitroarginine; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D019331:NG-Nitroarginine Methyl Ester