In vivo angiogenesis by platelet-derived wound-healing formula in injured spinal cord.
In vivo angiogenesis was investigated using platelet-derived wound-healing formula (PDWHF) in the injured cat spinal cord. Twenty-two gauge teflon sheaths, which had been coated with PDWHF-Hydron or only with Hydron, were inserted into the spinal cords of cats and the injured cats were maintained for 3 weeks. Selection of PDWHF-Hydron or Hydron was double blinded. The PDWHF-Hydron group showed notable neovascularization as well as dilation around the injury site, and this was statistically significant when compared to the control group. PDWHF seems to play a role in the healing processes of spinal cord injury and may have important interactions with other growth factors and in particular neurogenic growth factor.
Hiraizumi
Y
Y
Department of Orthopaedic Surgery, University of Minnesota, Minneapolis 55455.
Transfeldt
E E
EE
Kawahara
N
N
Sung
J H
JH
Knighton
D
D
Fiegel
V D
VD
D000818:Animals; D001792:Blood Platelets; D002415:Cats; D045424:Complex Mixtures; D004311:Double-Blind Method; D006133:Growth Substances / Q000627:therapeutic use*; D009389:Neovascularization, Pathologic / Q000139:chemically induced*; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000503:physiopathology; D014945:Wound Healing
C078881:CT-102 activated platelet supernatant; D045424:Complex Mixtures; D006133:Growth Substances