title: E-cadherin mediates adherens junction organization through protein kinase C.
abstract: Cultured human keratinocytes maintained in 30 microM Ca2+ do not form adherens junctions; however, when the extracellular Ca2+ concentration is raised to 1 mM, adherens junctions form very rapidly. The formation of a junction involves the coordinate organization of intracellular and extracellular components. Cadherins have been shown to mediate this coordinate organization. In this report we show that E-cadherin organizes the various junctional components by signalling through protein kinase C.
authors.affiliation: Department of Biology, University of Toledo, OH 43606.
authors.forename: J E
authors.initials: JE
authors.lastname: Lewis
authors.forename: P J
authors.initials: PJ
authors.lastname: Jensen
authors.forename: K R
authors.initials: KR
authors.lastname: Johnson
authors.forename: M J
authors.initials: MJ
authors.lastname: Wheelock
mesh_terms: D015820:Cadherins / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004789:Enzyme Activation; D005455:Fluorescent Antibody Technique; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism*; D015603:Keratinocytes / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D011493:Protein Kinase C / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D015820:Cadherins; D011493:Protein Kinase C; D002118:Calcium