title: IgG interference in second generation enzymeimmunoassays for anti-hepatitis C virus antibodies.
abstract: The interference of endogenous IgG in the identification of anti-HCV antibodies was studied in three second-generation enzymeimmunoassays. The addition of increasing concentrations of this immunoglobulin led to the appearance of false positives. The results obtained confirm the hypothesis that a non-specific binding of the IgG with the support material used was responsible for this interference.
authors.affiliation: Laboratorio Central, Hospital San Millàn, Logroño, España.
authors.forename: L
authors.initials: L
authors.lastname: Borque
authors.forename: C
authors.initials: C
authors.lastname: Maside
authors.forename: A
authors.initials: A
authors.lastname: Rus
authors.forename: A
authors.initials: A
authors.lastname: Elena
authors.forename: J
authors.initials: J
authors.lastname: del Cura
authors.forename: M J
authors.initials: MJ
authors.lastname: Gastañares
mesh_terms: D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D018937:Hepatitis C Antibodies; D006801:Humans; D007124:Immunoenzyme Techniques / Q000706:statistics & numerical data; D007074:Immunoglobulin G / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G