Involvement of nitric oxide in basal and interleukin-1 beta-induced CRH and ACTH release in vitro.
NG-Nitro-L-arginine, an inhibitor of nitric oxide synthase, does not influence CRH basal release but is able to modify ACTH basal secretion and to block interleukin-1 beta-induced CRH and ACTH release from rat hypothalamic and anterior pituitary cell cultures in vitro. The data suggest a different involvement of NO at hypothalamic and pituitary level.
Brunetti
L
L
Department of Pharmacology, G. D'Annunzio University, Chieti, Italy.
Preziosi
P
P
Ragazzoni
E
E
Vacca
M
M
D000324:Adrenocorticotropic Hormone / Q000187:drug effects* / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors; D000704:Analysis of Variance; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D002478:Cells, Cultured; D003346:Corticotropin-Releasing Hormone / Q000187:drug effects* / Q000378:metabolism; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D008297:Male; D009569:Nitric Oxide / Q000494:pharmacology*; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D007375:Interleukin-1; D019335:Nitroarginine; D009569:Nitric Oxide; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases