Effect of copper sulfate on experimental atherosclerosis.
Serum copper concentration increases significantly (p < 0.01) in rats with experimental atherosclerosis compared to a control group. The serum zinc, the zinc, and copper concentration in abdominal aorta and in liver decreases significantly (p < 0.05) compared to the control group. Administration of copper sulfate for 100 d in these animals induces a significant increase of serum copper (p < 0.01), decrease of serum cholesterol (p < 0.05) and increase of liver copper concentration as compared with the group fed only a high cholesterol diet. In the aorta of these animals the copper concentration increases and edema and lipid infiltration are considerably less than in the group of animals fed only a high lipid diet.
Vlad
M
M
Institute of Public Health and Medical Research, Cluj-Napoca, Romania.
Bordas
E
E
Tomus
R
R
Sava
D
D
Farkas
E
E
Uza
G
G
D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000494:pharmacology; D003300:Copper / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019327:Copper Sulfate; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000097:blood / Q000378:metabolism
D002791:Cholesterol, Dietary; D003300:Copper; D002784:Cholesterol; D015032:Zinc; D019327:Copper Sulfate