title: CD5 positive B lymphocytes in schizophrenia: no alteration in numbers or percentage as compared with control subjects.
abstract: Some patients with autoimmune disease have an elevation of the B lymphocyte population bearing the CD5 marker. In an attempt to replicate an earlier report of elevated CD5+ B cells in schizophrenic patients, lymphocytes were phenotyped in 116 patients with schizophrenia and 166 control subjects. The CD5+ B lymphocyte population was not elevated in medicated or never-medicated patients as compared with control subjects of similar age, race, gender, or social class. CD5+ B cells were also not elevated in patients who had circulating autoantibodies. The CD5+ B lymphocyte population was significantly elevated in African-American control subjects and patients in comparison with that in Caucasian control subjects and patients. Thus, although other immune alterations characterized a subset of patients with schizophrenia, an elevation of the CD5+ B lymphocyte population was not found in this study.
authors.affiliation: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA.
authors.forename: R
authors.initials: R
authors.lastname: Ganguli
authors.forename: B S
authors.initials: BS
authors.lastname: Rabin
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology / Q000523:psychology; D001402:B-Lymphocytes / Q000276:immunology*; D015415:Biomarkers; D018956:CD5 Antigens; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis / Q000276:immunology*; D012565:Schizophrenic Psychology
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D018956:CD5 Antigens