HLA molecule expression in cutaneous squamous cell carcinomas: an immunopathological study and clinical-immunohistopathological correlations.
A correlation between the lack of MHC class I gene expression on murine tumor cells and their ability to grow and metastasize has recently been established. This paper studies HLA-ABC and HLA-DR antigen expression in tumor cells and mononuclear infiltrate of 26 cutaneous squamous cell carcinomas (SCC). Our results showed a heterogeneous expression of HLA class I molecules in these tumors. No significant correlation between the degree of HLA class I molecule expression and anatomical-clinical parameters was found. Class II antigen expression was correlated to the histopathological type and to the degree of cell differentiation. Most mononuclear cells infiltrating the tumor were T-lymphocytes. No correlation with anatomical-clinical parameters was found.
García-Plata
D
D
Department of Dermatology, University of Córdoba, Spain.
Mozos
E
E
Carrasco
L
L
Solana
R
R
D015703:Antigens, CD / Q000096:biosynthesis; D018949:Antigens, CD1; D014408:Biomarkers, Tumor; D017252:CD3 Complex / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006680:HLA Antigens / Q000096:biosynthesis*; D015234:HLA-A Antigens / Q000096:biosynthesis; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D008213:Lymphocyte Activation / Q000276:immunology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D015703:Antigens, CD; D018949:Antigens, CD1; D014408:Biomarkers, Tumor; D017252:CD3 Complex; D006680:HLA Antigens; D015234:HLA-A Antigens; D006684:HLA-DR Antigens