Non-antigen signals for B-cell growth and differentiation to antibody secretion.
Recently, significant progress had been made in understanding the T-B lymphocyte interactions that control humoral immunity. This review highlights experiments that demonstrate a central role for interactions between T-cell-B-cell-activating molecule (CD40 ligand) expressed on T cells and CD40 on B cells in B-cell activation and immunoglobulin isotype switching, both in vitro and in vivo.
Lederman
S
S
Columbia University, College of Physicians and Surgeons, New York.
Yellin
M J
MJ
Covey
L R
LR
Cleary
A M
AM
Callard
R
R
Chess
L
L
D000818:Animals; D000917:Antibody Formation; D015703:Antigens, CD / Q000502:physiology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000502:physiology*; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D019013:CD40 Antigens; D023201:CD40 Ligand; D002448:Cell Adhesion; D002454:Cell Differentiation; D006224:Cricetinae; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology*; D008211:Lymphocyte Cooperation; D008222:Lymphokines / Q000502:physiology; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D019013:CD40 Antigens; D008222:Lymphokines; D008562:Membrane Glycoproteins; D023201:CD40 Ligand