title: [Value of buflomedil in vascular radiology of hepatoma].
abstract: This double-blind cross-over study was carried out in 16 patients (16 arteriographies). In order to evaluate the intra-arterial infusion of buflomédil during arteriographies with lipiodol for the positive and staging diagnosis of hepatocarcinoma and in arteriolar chemoembolisation during a second period for the treatment of the known hepatocarcinoma. The intra-arterial effect of buflomédil was studied by measuring the up-stream reflux of the catheter during the infusion, the number of lesions and the suppression of arterial spasms. The buflomédil infusion decreased the upstream reflux, the number of spasms in the hepatic artery observed during the reiterated chemoembolisations. On the other hand, the visualisation of the limits and number of nodular lesions was impaired and under-estimated by excessive impregnation of the tissue by the contrast medium. In one case buflomédil permitted to visualize an arterio-portal fistula unrecognized under placebo. The clinical tolerance was good with no side-effects. The systolic and diastolic blood pressure did not change versus placebo. The buflomédil infusion during chemoembolisation makes the technique potentially safer by decreasing the up-stream reflux and spasms of hepatic arteries.
authors.affiliation: Service de Radiologie, Centre Hospitalier St Joseph, St Luc, Lyon.
authors.forename: J C
authors.initials: JC
authors.lastname: Emery
authors.forename: G
authors.initials: G
authors.lastname: Genin
authors.forename: S
authors.initials: S
authors.lastname: Bonvoisin
authors.forename: M
authors.initials: M
authors.lastname: Croisille
mesh_terms: D000368:Aged; D000792:Angiography / Q000379:methods*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000628:therapy; D004621:Embolization, Therapeutic / Q000379:methods; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011759:Pyrrolidines / Q000008:administration & dosage / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D011759:Pyrrolidines; D014665:Vasodilator Agents; C010651:buflomedil