title: First-trimester free beta (hCG) screening for Down syndrome.
abstract: Maternal serum free beta (hCG) levels are elevated (median 2.20 MOM) in the first trimester of pregnancy in 38 Down syndrome cases as compared with appropriate controls. This observation may form the basis for its use as a marker in screening for Down syndrome in the first trimester. Altered levels of the free beta analyte are observed in pregnancy conditions or complications other than Down syndrome.
authors.affiliation: NTD Laboratories Inc., Carle Place, NY 11514.
authors.forename: J N
authors.initials: JN
authors.lastname: Macri
authors.forename: K
authors.initials: K
authors.lastname: Spencer
authors.forename: D
authors.initials: D
authors.lastname: Aitken
authors.forename: K
authors.initials: K
authors.lastname: Garver
authors.forename: P D
authors.initials: PD
authors.lastname: Buchanan
authors.forename: F
authors.initials: F
authors.lastname: Muller
authors.forename: A
authors.initials: A
authors.lastname: Boue
mesh_terms: D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004311:Double-Blind Method; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments