Search for a therapy against soman-intoxication.
This mini-review mainly describes a part of the pharmacological research carried out in our laboratory during the past decades, aimed at finding a therapy against intoxication by cholinesterase-inhibiting organophosphates, in particular against the nerve agent soman. In particular soman, because this is one of the nerve agents that consistently appears to be very resistant to treatment. Various experimental approaches are described. Yet, even after all these years of research an adequate (pre)treatment against poisoning by soman is still not available.
Wolthuis
O L
OL
Medical Biological Laboratory TNO Lange Kleiweg 139, Rijswijk, The Netherlands.
van Helden
H P
HP
Melchers
B P
BP
Busker
R W
RW
de Groot
D M
DM
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D006801:Humans; D012999:Soman / Q000037:antagonists & inhibitors* / Q000633:toxicity*
D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D012999:Soman