Detection of the cellular membrane proteins on human T cell leukemia virus type I.
The presence of cellular membrane proteins on human T cell leukemia virus type I (HTLV-I) was examined. ICAM-1 and MHC-IIDR, which were highly expressed on MT-2 cells but not on MOLT-4#8 cells, became detectable on HTLV-I-binding MOLT-4#8 cells. Furthermore, a batch of other cellular molecules including LFA-1, ICAM-1, LFA-3, MHC-I, MHC-IIDR, and CD4 became detectable on HTLV-I-binding BW5147 cells, a mouse T-lymphoma cell line, which were able to adsorb HTLV-I. The detectable levels of these molecules were correlated with those expressed on MT-2 cells. The detectable levels of the cellular proteins of human decreased by pretreatment of HTLV-I with sera from HTLV-I seropositive individuals but not from seronegatives. These results indicate that HTLV-I envelope carries cellular membrane proteins derived from the host cell.
Akari
H
H
Department of Veterinary Microbiology, Faculty of Agriculture, Miyazaki University, Japan.
Goto
Y
Y
Shinjo
T
T
D000327:Adsorption; D000818:Animals; D002460:Cell Line; D006684:HLA-DR Antigens / Q000032:analysis / Q000276:immunology; D006649:Histocompatibility Antigens / Q000032:analysis; D015368:Human T-lymphotropic virus 1 / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000276:immunology; D008565:Membrane Proteins / Q000032:analysis*; D014407:Tumor Cells, Cultured
D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens; D008565:Membrane Proteins; D018799:Intercellular Adhesion Molecule-1