[Evaluation of the efficacy of intra-articular administration of somatostatin in rheumatoid arthritis].
The above study was undertaken in order to evaluate the efficacy of intra-articular somatostatin in rheumatoid arthritis. Twelve patients were enrolled and all of them concluded the experiment of three consecutive intra-articular somatostatin injections of 750 mcg at two-weekly intervals. All patients reported a statistically significant reduction in painful symptomatology, particularly of pain during active movement, pain at climbing stairs, and morning stiffness. In one patient, telethermography revealed complete subsidence of articular inflammation. There were neither local nor systemic side effects.
Fioravanti
A
A
Istituto di Reumatologia, Università degli Studi di Siena.
Franci
A
A
Gelli
R
R
Minari
C
C
Montemerani
M
M
Moscato
P
P
Marcolongo
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D013004:Somatostatin / Q000008:administration & dosage* / Q000494:pharmacology; D013373:Substance P / Q000037:antagonists & inhibitors; D013817:Thermography
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013373:Substance P; D013004:Somatostatin