[Quantitative and qualitative criteria for assessing the efficacy of antimutagens in an experiment].
The antimutagenic effect of para-aminobenzoic acid, tocopherol, adenosine and caffeine has been studied in experiments with microorganisms, Crepis capillaris seed cells, human lymphocytes, murine bone marrow cells in vivo. The activity, of antimutagens, their nature and action range, effective concentrations have been assessed. The type and severity of removable damages have been identified. Quantitative criteria for evaluating the effects of antimutagens have been defined.
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D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D002110:Caffeine / Q000494:pharmacology; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D019684:Magnoliopsida / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D051379:Mice; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D012639:Seeds / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D016587:Antimutagenic Agents; D001565:Benzoates; D004338:Drug Combinations; D014810:Vitamin E; D002110:Caffeine; C025741:caffeine, sodium benzoate drug combination; D024502:alpha-Tocopherol; D000241:Adenosine; D024505:Tocopherols; D010129:4-Aminobenzoic Acid