Mer-A2026A and B, novel piericidins with vasodilating effect. I. Producing organism, fermentation, isolation and biological properties.
A strain of Streptomyces was found to produce new piericidins. The compounds were purified and separated into two substances named Mer-A2026A and B. These new piericidins exhibited vasodilating and depressor activities.
Kominato
K
K
Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
Watanabe
Y
Y
Hirano
S
S
Kioka
T
T
Terasawa
T
T
Yoshioka
T
T
Okamura
K
K
Tone
H
H
D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005285:Fermentation; D008297:Male; D011725:Pyridines / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D014665:Vasodilator Agents / Q000302:isolation & purification* / Q000494:pharmacology
D000959:Antihypertensive Agents; C092865:Mer A2026A; C092866:Mer A2026B; D011725:Pyridines; D014665:Vasodilator Agents