title: 85Sr contaminant as a reliable tracer of 89Sr for monitoring urinary radioactivity in patients treated with 89Sr for bone metastases.
abstract: Measurement of radioactivity levels in the urine of patients undergoing strontium-89 therapy can be used to evaluate the efficacy of therapy or for patient's management (radiation protection rules and waste disposal). The complex beta counting procedures require extensive sample manipulation during preparation of the liquid scintillation cocktail. The high activity levels that may be found permit one to measure 89Sr activity sample by counting the low yield gamma emission (909 keV) of the radionuclide. However, the contamination of 85Sr due to the reaction for producing 89Sr, if measured with sufficient precision, could be used to evaluate 89Sr activity in urine samples. In other words, the contaminant 85Sr can be used as a tracer of 89Sr. This method was tested in four patients and the accuracy was found to be sufficient to obtain the individual time-activity curves of the urinary excretion.
authors.affiliation: Medical Physics Department, Spedali Civili di Brescia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: De Agostini
authors.forename: L
authors.initials: L
authors.lastname: Mascaro
authors.forename: C
authors.initials: C
authors.lastname: Pizzocaro
authors.forename: M B
authors.initials: MB
authors.lastname: Panarotto
authors.forename: M
authors.initials: M
authors.lastname: Bestagno
mesh_terms: D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008991:Monitoring, Physiologic; D009382:Neoplasms, Unknown Primary / Q000532:radiotherapy*; D010166:Palliative Care / Q000379:methods*; D013326:Strontium Radioisotopes / Q000627:therapeutic use* / Q000652:urine
chemical_list: D013326:Strontium Radioisotopes