[The antistressor action of dibunol in surgical stress in lung cancer patients].
Dibunol (butylhydroxytoluene) in 1-g capsules was given to lung cancer patients, 4 g for two days and 4 g for one day before surgery. The level of stress was evaluated by the blood levels of cortisole, by the daily urinary concentrations of 17-keto- and 17-ketogenic steroids, and by the blood levels medium-weight molecular peptides and toxic indices 1, 3, 5-7 days of postsurgery. The antistress action of the agent appeared as twofold decreased blood cortisol and urinary 17-KS and 17-KGS 1 day after surgery, returning to the baseline on day 3 (while there was no normalization even on day 7 if dibunol was not given), and as significantly declined intoxication indices.
Baraboĭ
V A
VA
Bororov
L V
LV
Gunina
L M
LM
Maevskaia
L P
LP
D015068:17-Ketosteroids / Q000652:urine; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage*; D002214:Capsules; D004341:Drug Evaluation; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008175:Lung Neoplasms / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D008970:Molecular Weight; D010455:Peptides / Q000097:blood; D011013:Pneumonectomy; D011184:Postoperative Period; D011300:Preoperative Care / Q000379:methods*; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D013997:Time Factors
D015068:17-Ketosteroids; D002214:Capsules; D010455:Peptides; D002084:Butylated Hydroxytoluene; D006854:Hydrocortisone