Post-exercise albuminuria does not predict microalbuminuria in type 1 diabetic patients.
To investigate whether post-exercise urinary albumin excretion in Type 1 diabetic children and adolescents may prospectively predict the development of microalbuminuria, we have assessed post-exercise urinary albumin excretion before and after 6.2 +/- 1.7 years of follow-up in 66 diabetic children and adolescents. Post-exercise urinary albumin excretion rose significantly above the pre-exercise values in diabetic patients by 2.7 (-3.8 to 84.2) micrograms min-1 (p < 0.001) and in a group of 9 healthy individuals by 3.9 (-0.7 to 13.7) micrograms min-1 (p < 0.02) without significant differences between groups. Post-exercise albuminuria was greater in postpubertal than prepubertal 9.8 vs 4.3 micrograms min-1 (p < 0.03) and pubertal 9.8 vs 6.0 micrograms min-1 (p < 0.02) patients; post-exercise changes in urinary albumin excretion were also positively related to glycated haemoglobin (r = 0.293; p < 0.05). Eight out of 66 patients developed microalbuminuria at follow-up. Urinary albumin excretion at follow-up was comparable between patients with normal and abnormal post-exercise urinary albumin excretion; moreover post-exercise urinary albumin excretion was within the normal range in 5 out of 8 patients with microalbuminuria at follow-up. In conclusion post-exercise albuminuria does not seem to be a useful predictor of the onset of microalbuminuria in Type 1 diabetic children and adolescents.
Bognetti
E
E
Paediatric Department, Scientific Institute H San Raffaele, University of Milano, Italy.
Meschi
F
F
Pattarini
A
A
Zoja
A
A
Chiumello
G
G
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D011237:Predictive Value of Tests