Cyclosporin A, FK506 and rapamycin: more than just immunosuppression.
The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
Kunz
J
J
Department of Biochemistry, University of Basel, Switzerland.
Hall
M N
MN
D000591:Amino Acid Isomerases / Q000378:metabolism; D000595:Amino Acid Sequence; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D016384:Consensus Sequence; D016572:Cyclosporine / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008969:Molecular Sequence Data; D019696:Peptidylprolyl Isomerase; D019869:Phosphatidylinositol 3-Kinases; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism; D011090:Polyenes / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D020123:Sirolimus; D016559:Tacrolimus / Q000494:pharmacology*
D000591:Amino Acid Isomerases; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D016572:Cyclosporine; D007166:Immunosuppressive Agents; D019696:Peptidylprolyl Isomerase; D019869:Phosphatidylinositol 3-Kinases; D010749:Phosphoprotein Phosphatases; D017853:Phosphotransferases (Alcohol Group Acceptor); D011090:Polyenes; D020123:Sirolimus; D016559:Tacrolimus