[The efficacy of universal vaccination against the hepatitis B virus. Simulation with a mathematical model].
We present a mathematical model of the hepatitis B virus (HBV) infection in a community. The main object is to analyze the effects of two different strategies of mass vaccination: newborns or adolescents. It appears that adolescents mass vaccination produces in the short-term a bigger effect than in the newborns. Mathematically, the model is a system of non linear first order differential equations, in which each function is a related class of individuals (susceptible, infectious, carrier, immune and death by HBV) in the evolution of the HBV. The solution of system is obtained in a numerical way. It should be pointed out that the model explains neatly the herd immunity effect of the vaccine and can be used in the simulation of possible changes in the HBV infection such that generalized use of discarded needles by the drug addicted population, changes in the sexual habits, etc.
Torrea Hernández
J L
JL
Departamento de Matemáticas, Facultad de Ciencias, Universidad Autónoma, Madrid.
Gaurz Bellido
R
R
D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000276:immunology / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D004341:Drug Evaluation; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D013030:Spain
D017325:Hepatitis B Vaccines