title: Antigenic and functional differences in adhesion of Plasmodium falciparum-infected erythrocytes to human and bovine CD36.
abstract: Cytoadherence by Plasmodium falciparum-infected erythrocytes (PRBC) to microvascular endothelium is, in part, mediated by the specific interaction between a parasite-derived erythrocyte surface ligand and a specific binding site on human CD36. We describe the selection for increased adhesion of PRBC to bovine CD36 and demonstrate that the molecular interaction between PRBC and bovine CD36 is independent of and distinct from the OKM5/8 monoclonal antibody epitopes which block PRBC-human CD36 binding.
authors.affiliation: Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20307.
authors.forename: C F
authors.initials: CF
authors.lastname: Ockenhouse
authors.forename: N N
authors.initials: NN
authors.lastname: Tandon
authors.forename: G A
authors.initials: GA
authors.lastname: Jamieson
authors.forename: D E
authors.initials: DE
authors.lastname: Greenwalt
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism*; D018955:CD36 Antigens; D002417:Cattle; D002448:Cell Adhesion; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D010963:Plasmodium falciparum / Q000276:immunology / Q000472:pathogenicity*; D010980:Platelet Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018955:CD36 Antigens; D010980:Platelet Membrane Glycoproteins