Variable tissue reactions and endocrine responses to a jugular catheter.
Although the use of soft catheter materials allows for safe long-term venous access in humans and animals, a significant percentage of individuals react adversely. We have studied a group of 52 male rats over 30 days (d) for the category and degree of tissue responses to silicone-based catheters implanted in the jugular vein. Included in this evaluation was blood withdrawal at multiple intervals for assay of plasma hormones corticosterone (CORT) and prolactin (PRL) as they were correlated with the immune phenomena associated with early (5-7d) obstruction of the catheter tip. The intravascular portion of all catheters were covered with a transparent sheath which was composed of endothelial cells, smooth muscle cells, fibroblasts and numerous collagen fibers. Early blockage of catheters was the result of large white masses (wm) enclosing the tip which were continuous with the sheath. The wm consisted of: a) an inner zone nearest the catheter in some regions predominantly composed of numerous platelets and in others granulocytes and platelets; b) a middle zone containing numerous neutrophils; c) an outer zone containing a few inflammatory cells and many spaces filled with red blood cells. Rats that developed a wm blockage 7-10d after catheter placement had higher plasma CORT levels (3-5d post implant) when compared to those of animals with catheters remaining open 3-4 weeks. When viewed together, these observations describe a subset of a larger population of rats that have a local intravascular inflammatory reaction to silicone-based catheters. This preparation may be a useful model for investigating reported differences in human reactivity to silicone-based prostheses.
Phelps
C P
CP
Department of Anatomy, College of Medicine, University of South Florida, Tampa 33612.
Chen
L T
LT
Oliver
J
J
Poole
L L
LL
Menzies
R A
RA
D000818:Animals; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D003345:Corticosterone / Q000097:blood*; D007249:Inflammation; D007601:Jugular Veins / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D011388:Prolactin / Q000097:blood*; D051381:Rats; D013927:Thrombosis
D011388:Prolactin; D003345:Corticosterone