In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog.
A novel method for visualization of brain acetylcholinesterase (AChE) in vivo has been developed. Following intravenous administration of a radiolabelled acetylcholine analog, N-methyl-3-piperidyl acetate, there was very good agreement between the distribution of radioactivity and AChE activity in the brain of rat and monkey. The method would be applicable for in vivo studies of human brain AChE activity in disorders of central cholinergic systems such as Alzheimer's disease.
Namba
H
H
Division of Neurological Surgery, Chiba Cancer Center Hospital, Japan.
Irie
T
T
Fukushi
K
K
Iyo
M
M
D000109:Acetylcholine / Q000031:analogs & derivatives / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000000981:diagnostic imaging / Q000201:enzymology*; D005625:Frontal Lobe / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D017072:Neostriatum / Q000378:metabolism; D010296:Parietal Lobe / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013377:Substantia Innominata / Q000201:enzymology; D014055:Tomography, Emission-Computed
D015415:Biomarkers; D000110:Acetylcholinesterase; D000109:Acetylcholine