[Effect of essential phospholipids on the structural and metabolic changes in the rat liver in experimental alcoholic intoxication].
The paper deals with studies into the mechanism of hepatoprotective action of essential phospholipids (EP) in chronic alcohol intoxication. EPs reduce the count of hepatocytes with hypotopic and fatty dystrophic signs, normalize hepatic triglycerides. The EP antioxidative effect found is associated with vitamin E admixture in the preparation. EPs reduce the level of cAMP and the activity of adenylate cyclase. The activity of cAMP-dependent protein kinase becomes normal only with high doses of EP (300 mg/kg). It is suggested that the hepatoprotective effect of EP may be manifested through normalization of the cAMP-dependent transduction of a signal, resulting in stabilization of hepatic metabolic processes.
Buko
V U
VU
Nemkevich
V V
VV
Mal'tsev
A N
AN
Nikitin
V S
VS
Malyshko
I A
IA
Ignatenko
K V
KV
Gundermann K-I
Shumakher
R
R
D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D008108:Liver Diseases, Alcoholic / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010743:Phospholipids / Q000627:therapeutic use*; D051381:Rats
D010743:Phospholipids