Limited regulatory effect of T cell receptor-derived peptides.
T cell receptor (TCR)-derived peptides have been used to induce regulatory T cells which recognize T cells of specific elements and downregulate the autoimmune response. Consistent with these observations, priming of peptides corresponding to V beta 8 complementarity-determining region 2 (CDR2) was found to specifically suppress the proliferation of V beta 8+ T cells in the draining lymph nodes. Similarly, the generation of V beta 8-dominant T cell responses was prevented locally by vaccination with V beta 8 CDR2 peptides. There was a good correlation between the downregulation of V beta 8+ T cells and the inhibition of the corresponding T cell responses in different lymphoid tissues. No systemic inhibition could be detected even after an interval which would allow the redistribution of the "regulatory T cells." T cells specific for V beta 8 CDR2 peptides was generated following peptide immunization. However, the appearance of these TCR peptide-specific T cells was independent of the downregulation of V beta 8+ T cells. The transient and localized inhibitory effects of TCR-derived peptides indicate that these peptides have very limited use in regulating specific T cell response.
Hsueh
Y P
YP
Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan, ROC.
Yang
Y F
YF
Liang
H E
HE
Han
S H
SH
Lai
M Z
MZ
D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D015536:Down-Regulation; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis*; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013601:T-Lymphocytes / Q000276:immunology*
D010455:Peptides; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; C075784:T cell receptor Vbeta8