Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis.
Two forms of a member of the POU domain family of transcriptional regulators, highly related to Oct-2, are selectively expressed in terminally differentiating epidermis and hair follicles. One form, referred to as Skn-1i, contains an amino-terminal domain that inhibits DNA binding and can inhibit transactivation by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression. The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development.
Andersen
B
B
Eukaryotic Regulatory Biology Program, Howard Hughes Medical Institute, University of California School of Medicine, San Diego, La Jolla 92093.
Schonemann
M D
MD
Flynn
S E
SE
Pearse
R V
RV
Singh
H
H
Rosenfeld
M G
MG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D050976:Basic-Leucine Zipper Transcription Factors; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D004817:Epidermis / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects; D007633:Keratins / Q000235:genetics; D016350:Leucine Zippers; D046911:Macromolecular Substances; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D050813:Octamer Transcription Factor-2; D016133:Polymerase Chain Reaction; D012097:Repressor Proteins; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology
D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D050813:Octamer Transcription Factor-2; C489206:Pou2f2 protein, mouse; C489205:Pou2f2 protein, rat; D012097:Repressor Proteins; C489490:TEF protein, human; C489491:Tef protein, mouse; D014157:Transcription Factors; D007633:Keratins; D004247:DNA