title: Prognosis of patients with nonmalignant chronic intestinal failure receiving long-term home parenteral nutrition.
abstract: OBJECTIVE
  Long-term survival of patients with intestinal failure requiring home parenteral nutrition (HPN) has been only partly shown. Therefore, we described the survival of these patients and explored prognosis factors.
  
  
  METHODS
  Two hundred seventeen noncancer non-acquired immunodeficiency syndrome adult patients presenting with chronic intestinal failure enrolled from January 1980 to December 1989 in approved HPN programs in Belgium and France; prognosis factors of survival were explored using multivariate analysis. Data were updated in March 1991; not one of the patients was lost to follow-up.
  
  
  RESULTS
  Seventy-three patients died during the survey, and the mortality rate related to HPN complications accounted for 11% of deaths. Probabilities of survival at 1, 3, and 5 years were 91%, 70%, and 62%, respectively. Three independent variables were associated with a decreased risk of death: age of patients younger than 40 years, start of HPN after 1987, and absence of chronic intestinal obstruction. In patients younger than 60 years of age included after 1983 with a very short bowel, who could represent suitable candidates for small bowel transplantation, the 2-year survival rate was 90%, a prognosis that compared favorably with recent reports of survival after small bowel transplantation.
  
  
  CONCLUSIONS
  HPN prognosis compares favorably with recent reports of survival after small bowel transplantation.
authors.affiliation: Hôpital Saint-Lazare, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Messing
authors.forename: M
authors.initials: M
authors.lastname: Lémann
authors.forename: P
authors.initials: P
authors.lastname: Landais
authors.forename: M C
authors.initials: MC
authors.lastname: Gouttebel
authors.forename: M
authors.initials: M
authors.lastname: Gérard-Boncompain
authors.forename: F
authors.initials: F
authors.lastname: Saudin
authors.forename: A
authors.initials: A
authors.lastname: Vangossum
authors.forename: P
authors.initials: P
authors.lastname: Beau
authors.forename: C
authors.initials: C
authors.lastname: Guédon
authors.forename: D
authors.initials: D
authors.lastname: Barnoud
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D007415:Intestinal Obstruction / Q000150:complications; D007421:Intestine, Small / Q000637:transplantation; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016331:Parenteral Nutrition, Home; D011379:Prognosis; D015996:Survival Rate