Cell division, chromosomal aberration, and micronuclei formation in human peripheral blood lymphocytes. Effect of stannic chloride on donor's age.
Age related cytotoxicity of stannic chloride was evaluated in human lymphocytes considering mitotic index (MI), damaged cell (DC), chromosome aberration (CA), and micronuclei formation (MNC) as endpoints. Significant elevation of DCs, CAs, MNCs, and reduction of MI were observed in all classified age groups compared to each control set. The mean frequencies of abnormalities show a statistically significant increase with subject's age. Linearity of the effect of age was common for both untreated and treated lymphocytes of both sexes.
Ganguly
B B
BB
Biochemistry Unit, Indian Statistical Institute, Calcutta.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002455:Cell Division / Q000187:drug effects; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D008940:Mitotic Index / Q000187:drug effects; D017971:Tin Compounds / Q000633:toxicity*
D017971:Tin Compounds; C041694:stannic chloride