title: Local danazol injection for treatment of unruptured tubal pregnancy (preliminary experience).
abstract: Fifteen women with unruptured tubal pregnancies diagnosed by laparoscopy and ultrasound were treated with danazol 400 mg, injected directly into the affected tube. Study inclusion criteria were (i) a rising or plateauing level of serum beta human chorionic gonadotropin (hCG), (ii) a tubal swelling less than 3 x 3 cm, (iii) an intact tubal serosa and (iv) no active bleeding. The women were monitored with serial measurements of beta-hCG. All women responded to a single danazol injection, no treatment failures were observed. After 3 months, hysterosalpinography revealed tubal pateny on the involved side in 14 patients and in 1 patient the tube was blocked. Within 1 year after danazol therapy patients were attempting to or had conceived. Of these, there were 3 intrauterine pregnancies and 2 recurrent contralateral pregnancies.
authors.affiliation: Department of Gynaecology and Obstetrics, Faculty of Medicine, Ain Shams University, Heliopolis, Cairo, Egypt.
authors.forename: A F
authors.initials: AF
authors.lastname: Ali
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003613:Danazol / Q000008:administration & dosage*; D005187:Fallopian Tubes; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D010535:Laparoscopy; D010446:Peptide Fragments / Q000097:blood; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D003613:Danazol