title: Review of the role of two antilibidinal drugs in the treatment of sex offenders with mental retardation.
abstract: A minority of individuals with mental retardation engage in offensive sexual behavior (e.g., child molestation, genital exposure, rape). Many of these individuals may benefit from the adjunctive administration of antilibidinal drugs. The two most widely used are the antiandrogens, medroxyprogesterone acetate (MPA) and cyproterone acetate (CPA). In the present paper the efficacy, cautions, side effects, and mode(s) of action of these substances were reviewed and medico-legal issues surrounding their use discussed. Controlled studies of antilibidinal agents with adequate numbers of patients using clearly defined (e.g., cognitive abilities) and valid and reliable outcome measures are needed.
authors.affiliation: St. Thomas Psychiatric Hospital, Ontario, Canada.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cooper
mesh_terms: D017373:Cyproterone Acetate / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007258:Informed Consent / Q000331:legislation & jurisprudence; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects / Q000627:therapeutic use*; D012742:Sex Offenses / Q000331:legislation & jurisprudence / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D017373:Cyproterone Acetate; D017258:Medroxyprogesterone Acetate