Acid-base regulation in peritoneal dialysis.
To prevent increased protein degradation and renal bone disease, optimal correction of acidosis should therefore be a priority in the management of CAPD patients. Initial results suggest that bicarbonate solutions may be more biocompatible than lactate, and one would expect increasing use over the next decade. Manufacturers could help to improve acid-base regulation in CAPD by providing a range of solutions with varying lactate and bicarbonate concentration, so that correction of acidosis could be optimized individually.
Graham
K A
KA
Department of Medicine, University of Newcastle upon Tyne, England, United Kingdom.
Reaich
D
D
Goodship
T H
TH
D000136:Acid-Base Equilibrium / Q000502:physiology; D000137:Acid-Base Imbalance / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D001639:Bicarbonates / Q000627:therapeutic use; D001851:Bone Diseases, Metabolic / Q000209:etiology; D015314:Dialysis Solutions / Q000627:therapeutic use; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications*; D007773:Lactates / Q000627:therapeutic use; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D011488:Protein Deficiency / Q000209:etiology
D001639:Bicarbonates; D015314:Dialysis Solutions; D007773:Lactates