title: Tuberculosis of the knee in children.
abstract: We reviewed 33 children with tuberculosis of the knee treated during the period from 1979 to 1991. All were treated with triple chemotherapy, using rifampicin, isoniazid and pyrazinamide for nine months. No patient had a synovectomy; surgery was limited to open biopsy or salvage procedures such as posterior release and arthrodesis for late stages of the disease. The radiological appearance of the knee at presentation predicted the outcome. The 30 patients with stage-1 (normal) or stage-2 (osteomyelitic) disease had excellent or good results; the three with narrowed joint spaces in stage 3 or stage 4 (arthritic) had fair or poor results. Early active mobilisation, as against long-term immobilisation, seemed to have no effect on the outcome of stage-1 or stage-2 disease.
authors.affiliation: Maitland Cottage Hospital, Cape Town, Republic of South Africa.
authors.forename: A S
authors.initials: AS
authors.lastname: Lee
authors.forename: J A
authors.initials: JA
authors.lastname: Campbell
authors.forename: E B
authors.initials: EB
authors.lastname: Hoffman
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007719:Knee Joint / Q000000981:diagnostic imaging; D008297:Male; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies; D016896:Treatment Outcome; D014394:Tuberculosis, Osteoarticular / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000995:Antitubercular Agents