title: [Cathepsin D activity in gastric cancer].
abstract: The levels of activity of cathepsin D were compared in neoplastic and normal gastric mucosa in 42 patients, aged 39-78, at different stages of the disease. A relationship was established between cathepsin D activity and main clinico-morphological characteristics of stomach tumor: cathepsin D activity was found to increase with decreasing differentiation and increasing depth of invasion and metastatic spreading of tumor tissue. Possible involvement of proteolytic enzymes and, in particular, an aspartyl proteinase--cathepsin D--in the mechanisms of invasion and metastatic spreading of neoplasms is discussed.
authors.forename: A L
authors.initials: AL
authors.lastname: Kantsaliev
authors.forename: E A
authors.initials: EA
authors.lastname: Kozyreva
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskiĭ
authors.forename: V I
authors.initials: VI
authors.lastname: Rottenberg
authors.forename: A A
authors.initials: AA
authors.lastname: Klimenkov
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000201:enzymology / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D002402:Cathepsin D / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology / Q000473:pathology; D006652:Histological Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D013053:Spectrophotometry; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery
chemical_list: D002402:Cathepsin D