title: Follow-up study of anti-hepatitis C virus antibodies in blood donors implicated in post-transfusion non-A, non-B hepatitis.
abstract: We retrospectively examined the antibodies to p22, a hepatitis C virus (HCV) nucleocapsid protein, and to c100-3, a HCV nonstructural protein, in donors whose blood was transfused to patients who later developed post-transfusion non-A, non-B hepatitis. Of 13 such blood donors, three seroconverted and three seroreverted with the anti-c100-3 test. In contrast, 12 of the 13 blood donors showed the same results at transfusion and follow-up, and one donor showed seroconversion with the anti-p22 assay. The follow-up study shows that the anti-p22 antibody test provides consistent results and is far more suitable for screening blood than the anti-c100-3 test.
authors.affiliation: Japanese Red Cross Tokyo Metropolitan Blood Center.
authors.forename: T
authors.initials: T
authors.lastname: Mazda
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: M
authors.initials: M
authors.lastname: Bannai
authors.forename: T
authors.initials: T
authors.lastname: Miyamura
authors.forename: J
authors.initials: J
authors.lastname: Chiba
authors.forename: H
authors.initials: H
authors.lastname: Ohba
authors.forename: Y
authors.initials: Y
authors.lastname: Kaminuma
authors.forename: T
authors.initials: T
authors.lastname: Katayama
mesh_terms: D000956:Antigens, Viral; D001782:Blood Donors; D001803:Blood Transfusion / Q000592:standards*; D004797:Enzyme-Linked Immunosorbent Assay; D005188:False Negative Reactions; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006526:Hepatitis C / Q000097:blood / Q000175:diagnosis / Q000517:prevention & control / Q000635:transmission*; D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; D006801:Humans; D008403:Mass Screening; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D012189:Retrospective Studies; D065227:Transfusion Reaction; D014758:Viral Core Proteins / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; C064544:C100 protein, hepatitis C virus; D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; D011933:Reagent Kits, Diagnostic; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins; C499352:core protein p22, Hepatitis C virus; C069130:nucleocapsid protein, Hepatitis C virus