title: Schistosoma mansoni: analysis of monoclonal antibodies reactive with gut-associated antigens.
abstract: The analysis of a series of monoclonal antibodies (mAbs) developed in our laboratory against gut-associated antigens of Schistosoma mansoni is described. It was found that mAbs that recognized epitopes of antigens in the gut and on the eggshell were mainly of the IgM isotype; these epitopes are likely to be carbohydrate in composition. Of a number of mAbs that were reactive with antigens important to the human humoral immune response, 75% appeared to be reactive with the circulating cathodic antigen.
authors.affiliation: Laboratory for Parasitology, University of Leiden, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: van Dam
authors.forename: D
authors.initials: D
authors.lastname: Kornelis
authors.forename: R J
authors.initials: RJ
authors.lastname: Van Zeyl
authors.forename: J P
authors.initials: JP
authors.lastname: Rotmans
authors.forename: A M
authors.initials: AM
authors.lastname: Deelder
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D000947:Antigens, Helminth / Q000276:immunology* / Q000302:isolation & purification; D006224:Cricetinae; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007422:Intestines / Q000276:immunology*; D008297:Male; D008647:Mesocricetus / Q000469:parasitology; D010063:Ovum / Q000276:immunology*; D012550:Schistosoma mansoni / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth; D000939:Epitopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M