title: Determination of risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography with electrochemical detection.
abstract: A method for the determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma has been developed. The procedure involved a multi-step liquid-liquid extraction with an internal standard. The parent drug and its metabolite were separated on a cyano column used in the reversed-phase model. The coulometric detection allows quantification in the range 2-100 ng/ml. The precision, accuracy and specificity have been checked, and show that the method is reliable for clinical studies.
authors.affiliation: Janssen Research Foundation, Laboratoires Janssen, Val de Reuil, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Le Moing
authors.forename: S
authors.initials: S
authors.lastname: Edouard
authors.forename: J C
authors.initials: JC
authors.lastname: Levron
mesh_terms: D014150:Antipsychotic Agents / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007555:Isoxazoles / Q000097:blood*; D000068882:Paliperidone Palmitate; D010880:Piperidines / Q000097:blood*; D011743:Pyrimidines / Q000097:blood*; D012044:Regression Analysis; D018967:Risperidone
chemical_list: D014150:Antipsychotic Agents; D007555:Isoxazoles; D010880:Piperidines; D011743:Pyrimidines; D018967:Risperidone; D000068882:Paliperidone Palmitate