Magnetic resonance imaging in kainic acid-induced limbic seizure status in cats.
Magnetic resonance imaging before, during, and after kainic acid (KA)-induced limbic seizure status in cats demonstrated the bilateral hippocampi as slightly high-intensity areas on the T2-weighted images during the limbic seizure status, and isointensity areas 1-2 weeks after KA injection when the limbic seizure status subsided. However, the hippocampi again became high-intense 1-3 months after KA injection. Histological study suggested that the high-intensity area during the limbic seizure status resulted from regional edema, and in the chronic period from marked gliosis and/or atrophic change as a consequence of tissue damage in the hippocampus.
Tanaka
S
S
Department of Neurosurgery, Asahikawa Medical College, Hokkaido.
Tanaka
T
T
Kondo
S
S
Hori
T
T
Fukuda
H
H
Yonemasu
Y
Y
Tanaka
M
M
Shindo
K
K
D000679:Amygdala / Q000187:drug effects / Q000473:pathology; D000818:Animals; D002415:Cats; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000139:chemically induced / Q000473:pathology; D017029:Epilepsy, Complex Partial / Q000139:chemically induced* / Q000473:pathology; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007608:Kainic Acid / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D013702:Temporal Lobe / Q000187:drug effects / Q000473:pathology
D007608:Kainic Acid