title: Clonal chromosome aberrations in cell cultures of synovial tissue from patients with rheumatoid arthritis.
abstract: Cytogenetic analysis of primary cell cultures and/or passages 1-3 of synovial tissue from seven patients with rheumatoid arthritis was performed. As the only recurrent chromosome aberration, trisomy 7 was found in six of seven cultures. In four cultures, trisomy 7 occurred as a clonal change in up to 20% of the analyzed cells, with an increase of the proportion of cells with +7 with the duration of the in vitro culture. Apart from this recurrent change, a variety of partly clonal, partly nonclonal numerical and structural chromosome aberrations were observed in all cases. These findings support the view that clonal chromosome aberrations may play a role in the pathogenesis of invasive growth of the synovial tissue in rheumatoid arthritis although the localized synovial hyperproliferation is not a true neoplastic process.
authors.affiliation: Institute of Human Genetics, Saarland University, Homburg/Saar, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ermis
authors.forename: T
authors.initials: T
authors.lastname: Hopf
authors.forename: R
authors.initials: R
authors.lastname: Hanselmann
authors.forename: K
authors.initials: K
authors.lastname: Remberger
authors.forename: C
authors.initials: C
authors.lastname: Welter
authors.forename: S
authors.initials: S
authors.lastname: Dooley
authors.forename: K D
authors.initials: KD
authors.lastname: Zang
authors.forename: W
authors.initials: W
authors.lastname: Henn
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000473:pathology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D002999:Clone Cells / Q000648:ultrastructure*; D006801:Humans; D013583:Synovial Membrane / Q000473:pathology*; D014314:Trisomy