Crude drugs from aquatic plants. V. On the constituents of alismatis rhizoma. (3). Stereostructures of water-soluble bioactive sesquiterpenes, sulfoorientalols a, b, c, and d, from Chinese alismatis rhizoma.
From the water-soluble portion of Chinese Alismatis Rhizoma, four bioactive sesquiterpenes, sulfoorientalols a, b, c, and d, were isolated and their structures having a sulfonic acid function were established on the basis of chemical and physicochemical evidence. In addition, two sulfoorientalol congeners were derived from alismol by sulfonation of the exo-methylene moiety. Sulfoorientalols and the synthetic congeners were found to inhibit the carbachol-induced contraction of isolated bladder smooth muscle of guinea pig.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Yamaguchi
S
S
Matsuda
H
H
Tanaka
N
N
Yamahara
J
J
Murakami
N
N
D000818:Animals; D002217:Carbachol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009130:Muscle, Smooth / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D013438:Sulfhydryl Compounds; D002217:Carbachol