Localization of the human CD59 gene by fluorescence in situ hybridization and pulsed-field gel electrophoresis.
We have localized the human CD59 gene encoding a membrane protein that inhibits cell lysis by the membrane-attack complex of the homologous complement system. Using chromosomal in situ suppression hybridization and pulsed-field gel electrophoresis, we mapped this gene to chromosome 11p13, distal to the breakpoint of acute T-cell leukemia and proximal to the locus of the Wilms' tumor gene on a 30-kb SacII fragment.
Heckl-Ostreicher
B
B
Institute of Immunology and Serology, Medical Faculty of Mannheim, FRG.
Ragg
S
S
Drechsler
M
M
Scherthan
H
H
Royer-Pokora
B
B
D015703:Antigens, CD / Q000235:genetics*; D018957:CD59 Antigens; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins / Q000235:genetics*; D015183:Restriction Mapping
D015703:Antigens, CD; D018957:CD59 Antigens; D008562:Membrane Glycoproteins