title: Characterization of an antigenic site on glycoprotein 13 (gC) of equid herpesvirus type-1.
abstract: Six monoclonal antibodies directed against EHV-1 glycoprotein 13 were characterized. Five antibodies neutralized EHV-1 and were directed against a single antigenic site which comprised type-specific and type cross-reactive epitopes. Inhibition of monoclonal antibody binding to this site by post-infection equine sera suggests that it is a target of host antibody during natural infection with either EHV-1 or EHV-4.
authors.affiliation: Department of Infectious Diseases, Animals Health Trust, Newmarket, Suffolk, England.
authors.forename: R
authors.initials: R
authors.lastname: Sinclair
authors.forename: B J
authors.initials: BJ
authors.lastname: Moult
authors.forename: J A
authors.initials: JA
authors.lastname: Mumford
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D006224:Cricetinae; D003429:Cross Reactions; D000939:Epitopes; D006023:Glycoproteins / Q000276:immunology*; D004861:Herpesvirus 1, Equid / Q000276:immunology*; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D006023:Glycoproteins; D014759:Viral Envelope Proteins