Topical treatment of ichthyoses and Darier's disease with 13-cis-retinoic acid. A clinical and immunohistochemical study.
In a bilaterally paired double-blind comparison study, a cream containing 0.1% 13-cis-retinoic acid (13-cis-RA) and cream base only were applied over 4 weeks in seven patients with non-erythrodermic lamellar ichthyosis (NELI), two patients with Darier's disease and one patient with autosomal dominant ichthyosis vulgaris (ADIV). In two patients with NELI and two patients with Darier's disease a half-side effect was observed in favour of the side treated with 13-cis-RA. In three patients an induction of cytokeratin-4, and in one of these patients expression of cytokeratin-13, were observed after therapy. Topical 13-cis-RA appears to be a promising approach in the treatment of disorders of keratinization. The selective modulation of the cytokeratin pattern may provide an immunohistochemical tool to investigate the mode of action of retinoids.
Steijlen
P M
PM
Department of Dermatology, University Hospital Nijmegen, The Netherlands.
Reifenschweiler
D O
DO
Ramaekers
F C
FC
van Muijen
G N
GN
Happle
R
R
Link
M
M
Ruiter
D J
DJ
van de Kerkhof
P C
PC
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D007644:Darier Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D017490:Ichthyosis, Lamellar / Q000188:drug therapy*; D007124:Immunoenzyme Techniques; D015474:Isotretinoin / Q000008:administration & dosage*; D007633:Keratins / Q000032:analysis; D008297:Male
D000911:Antibodies, Monoclonal; D007633:Keratins; D015474:Isotretinoin