title: In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae.
abstract: In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.
authors.affiliation: Department of Biological Sciences, Florida Institute of Technology, Melbourne 32901-6988.
authors.forename: A M
authors.initials: AM
authors.lastname: Dhople
authors.forename: M A
authors.initials: MA
authors.lastname: Ibanez
authors.forename: A A
authors.initials: AA
authors.lastname: Dhople
mesh_terms: D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000254:growth & development
chemical_list: D015082:2,2'-Dipyridyl