Human peripheral myelin protein-22 carries the L2/HNK-1 carbohydrate adhesion epitope.
Molecular genetic studies have established that mutations in the gene encoding the 22-kDa peripheral myelin protein (PMP-22) are responsible for hereditary peripheral neuropathies in the trembler mouse and in a subset of humans with Charcot-Marie-Tooth disease, type 1a. The function of the PMP-22 protein remains unknown. Several studies on myelin proteins in the PNS have indicated that the L2/HNK-1 epitope, which is believed to be both a ligand for cellular adhesion and a target for autoimmune monoclonal IgM neuritis, may be found on heretofore unidentified proteins with a molecular mass of 19-28 kDa. In this report, we provide immunological evidence that at least one of these proteins is PMP-22.
Snipes
G J
GJ
Department of Neurobiology, Stanford University School of Medicine, CA 94305.
Suter
U
U
Shooter
E M
EM
D000595:Amino Acid Sequence; D000906:Antibodies; D015703:Antigens, CD / Q000737:chemistry* / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000737:chemistry* / Q000276:immunology; D015153:Blotting, Western; D018959:CD57 Antigens; D002420:Cauda Equina / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000032:analysis*; D006801:Humans; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009185:Myelin Proteins / Q000737:chemistry* / Q000276:immunology / Q000302:isolation & purification; D009186:Myelin Sheath / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D010525:Peripheral Nerves / Q000737:chemistry*
D000906:Antibodies; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018959:CD57 Antigens; D000939:Epitopes; D009185:Myelin Proteins; C073687:PMP22 protein, human; D010455:Peptides; C489545:Pmp22 protein, mouse