title: Serial IMP-SPECT and EEG studies in an infant with hemimegalencephaly.
abstract: An 8-month-old girl of hypomelanosis of Ito associated with hemimegalencephaly had frequent seizures beginning 44 h after birth. The seizures were secondarily generalized or unilateral initially, followed by infantile spasms at about 1.5 months of age. Frequent partial seizures appeared at 4 months of age. [123I]N-Isopropyl-p-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) was performed serially during an interictal period at 1, 3 and 7 months of age. At 1 and 3 months, IMP-SPECT showed a marked increase of IMP uptake in the pathological left hemisphere and electroencephalography (EEG) revealed left-sided dominant hypsarrhythmia. At 7 months of age, a reversal was seen, there being decreased uptake on SPECT in the pathological hemisphere and abundant high amplitude background activity mingled with epileptic discharges on EEG in the non-pathological hemisphere. These serial changes of IMP uptake on SPECT seemed to reflect either changes in epileptic activity or maturational changes in cerebral perfusion in hemimegalencephaly.
authors.affiliation: Division of Pediatric Neurology, Osaka Medical Center, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tagawa
authors.forename: K
authors.initials: K
authors.lastname: Otani
authors.forename: Y
authors.initials: Y
authors.lastname: Futagi
authors.forename: A
authors.initials: A
authors.lastname: Wakayama
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
mesh_terms: D000367:Age Factors; D000662:Amphetamines; D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D020367:Iofetamine; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine