title: Topical treatment of ichthyoses and Darier's disease with 13-cis-retinoic acid. A clinical and immunohistochemical study.
abstract: In a bilaterally paired double-blind comparison study, a cream containing 0.1% 13-cis-retinoic acid (13-cis-RA) and cream base only were applied over 4 weeks in seven patients with non-erythrodermic lamellar ichthyosis (NELI), two patients with Darier's disease and one patient with autosomal dominant ichthyosis vulgaris (ADIV). In two patients with NELI and two patients with Darier's disease a half-side effect was observed in favour of the side treated with 13-cis-RA. In three patients an induction of cytokeratin-4, and in one of these patients expression of cytokeratin-13, were observed after therapy. Topical 13-cis-RA appears to be a promising approach in the treatment of disorders of keratinization. The selective modulation of the cytokeratin pattern may provide an immunohistochemical tool to investigate the mode of action of retinoids.
authors.affiliation: Department of Dermatology, University Hospital Nijmegen, The Netherlands.
authors.forename: P M
authors.initials: PM
authors.lastname: Steijlen
authors.forename: D O
authors.initials: DO
authors.lastname: Reifenschweiler
authors.forename: F C
authors.initials: FC
authors.lastname: Ramaekers
authors.forename: G N
authors.initials: GN
authors.lastname: van Muijen
authors.forename: R
authors.initials: R
authors.lastname: Happle
authors.forename: M
authors.initials: M
authors.lastname: Link
authors.forename: D J
authors.initials: DJ
authors.lastname: Ruiter
authors.forename: P C
authors.initials: PC
authors.lastname: van de Kerkhof
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D007644:Darier Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D017490:Ichthyosis, Lamellar / Q000188:drug therapy*; D007124:Immunoenzyme Techniques; D015474:Isotretinoin / Q000008:administration & dosage*; D007633:Keratins / Q000032:analysis; D008297:Male
chemical_list: D000911:Antibodies, Monoclonal; D007633:Keratins; D015474:Isotretinoin