Decreased delta-sleep and plasma delta-sleep-inducing peptide in patients with Cushing syndrome.
To evaluate the sleep disturbances of patients with Cushing syndrome and to examine the relationship between the sleep disturbances and plasma levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI), we performed three polysomnographic/endocrinological studies in patients with Cushing syndrome. In study 1, polysomnography was studied in 12 patients and 12 matched normal volunteers. In addition, DSIP-LI was measured every 30 min for 24 h in 9 patients with Cushing syndrome and 12 normal volunteers. The percentage of time spent in delta sleep (stages 3 and 4) was significantly reduced in patients with Cushing syndrome (5.8 +/- 1.4%; mean +/- SEM) compared to normal volunteers (14.0 +/- 2.5%) (p < 0.01). REM sleep indices, however, were not significantly different between the two groups. There was a significant negative correlation between amount of delta sleep and 08.00 h DSIP-LI (r = -0.43, p < 0.05), which is against the notion of a causal relationship between DSIP-LI and delta sleep. The circadian rhythm of plasma DSIP-LI was found to be similar in Cushing patients and normal volunteers. In study 2, we measured plasma levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) at 08.00 h in 65 patients with Cushing syndrome and 49 normal volunteers. The 08.00 h DSIP-LI concentrations of 797 +/- 57 pmol/l (mean +/- SEM) in the patients with Cushing syndrome were significantly reduced compared to the level of 1,062 +/- 99 pmol/l found in the normal volunteers (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Friedman
T C
TC
Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, MD 20892.
García-Borreguero
D
D
Hardwick
D
D
Akuete
C N
CN
Doppman
J L
JL
Dorn
L D
LD
Barker
C N
CN
Yanovski
J A
JA
Chrousos
G P
GP
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D016022:Case-Control Studies; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology; D003480:Cushing Syndrome / Q000097:blood / Q000503:physiopathology*; D003701:Delta Sleep-Inducing Peptide / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017591:Petrosal Sinus Sampling; D010902:Pituitary Gland / Q000378:metabolism; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000209:etiology; D012895:Sleep, REM / Q000502:physiology
D003701:Delta Sleep-Inducing Peptide; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone