Thermoradiotherapy combined with a proteolysis inhibitor (contrical) in the treatment of head and neck cancer.
For the prophylaxis of head and neck cancer recurrence and metastases we used radiation therapy, microwave hyperthermia and adjuvant therapy (inhibitor of proteolysis contrical and alpha-interferon). One hundred forty patients with primary cancer were treated. After 1 year of observation time and absence of tumor the patients were examined once every 3 months. The use of contrical and interferon combined with radiation therapy and microwave hyperthermia increased the 3-year survival rate by 37%, the number of patients without recurrence by 39% and decreased the appearance of regional metastases to 8.4%. Adjuvant therapy is discussed.
Mikhalkin
I A
IA
Division of Oncology, Kiev Research Institute of Otolaryngology, Ukraine.
Iashvili
Z G
ZG
Bykov
V L
VL
D007611:Aprotinin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000517:prevention & control*; D011879:Radiotherapy Dosage
D007611:Aprotinin