title: Polymorphism of the pentanucleotide repeat d(AAAAT) within intron 1 of the human tumor suppressor gene p53 (17p13.1).
abstract: DyeDeoxy terminator cycle sequencing of allele-specific polymerase chain reaction products has shown that there is a highly polymorphic d(AAAAT) pentanucleotide repeat within the first intron of the human p53 gene. This provides a genetic marker for tumor suppressor p53 gene alterations.
authors.affiliation: Institut für Biochemie, Justus-Liebig-Universität, Giessen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Hahn
authors.forename: R
authors.initials: R
authors.lastname: Fislage
authors.forename: A
authors.initials: A
authors.lastname: Pingoud
mesh_terms: D000483:Alleles; D001483:Base Sequence; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D017931:DNA Primers / Q000737:chemistry; D005787:Gene Frequency; D016158:Genes, p53 / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D017931:DNA Primers; D005819:Genetic Markers