title: Synthesis and preliminary pharmacological assessment of derivatives of isoxazolo[4,3-d]pyrimidine. II.
abstract: Some new derivatives of 5-alkylaminomethyl-3-benzoyl-7-oxo-6,7-dihydroisoxazolo[4,3- d]pyrimidine [II-VI] and 7-amine substituted 3-benzoyl-5-phenylisoxazolo[4,3-d]pyrimidine [VIII-X] were synthesized. Preliminary results of pharmacological screening of compounds synthesized as [II-V,IX,X] have been presented.
authors.affiliation: Department of Technology of Drugs, School of Medicine, Wrocław, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Poreba
authors.forename: E
authors.initials: E
authors.lastname: Wagner
authors.forename: I
authors.initials: I
authors.lastname: Jakowicz
authors.forename: D
authors.initials: D
authors.lastname: Balicka
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015195:Drug Design; D004597:Electroshock; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000737:chemistry / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D011619:Psychotropic Drugs; D011743:Pyrimidines; D010433:Pentylenetetrazole