Effect of intratracheally administered lindane on aldrin and benzo(a)pyrene contents in lungs of rats.
Pretreatment with lindane resulted in inhibition of benzo(a)pyrene hydroxylase activity in the lungs of rats. The enzyme activity tended to return to normal 5 days after the administration of lindane. Studies with benzo(a)pyrene and aldrin indicated reduced elimination of these compounds from the lungs of lindane-treated animals, suggesting that lindane may alter the clearance of certain substances or compounds from lungs. The delayed clearance of these compounds from lungs may be an indirect effect of lindane related to inhibition of certain metabolizing enzymes.
Khan
M A
MA
Industrial Toxicology Research Centre, Lucknow, India.
Matin
M A
MA
Beg
M U
MU
D000452:Aldrin / Q000378:metabolism*; D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism*; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001564:Benzo(a)pyrene; D001556:Hexachlorocyclohexane; D001579:Benzopyrene Hydroxylase; D000452:Aldrin