The detection and assessment of the aneugenic potential of environmental chemicals: the European Community Aneuploidy Project.
Within the framework of its' Environment Research and Development Programme, the European Communities (EC) Directorate General (DG) XII has supported a research project aimed at developing and validating assay systems for the detection and evaluation of chemicals capable of inducing numerical chromosome changes such as aneuploidy and polyploidy. A range of test chemicals were selected, which include a core set comprising; colchicine, econazole nitrate, chloral hydrate, hydroquinone, diazepam, thiabendazole, cadmium chloride, thimerosol, pyrimethamine and vinblastine sulphate. These test chemicals were used to evaluate the ability of test systems ranging from tubulin polymerisation, fungal cultures, cultured mammalian cells and intact rodents to detect chemical aneugens and to assess the significance of such activity to exposed human populations.
Parry
J M
JM
School of Biological Sciences, University College of Swansea, UK.
Sors
A
A
D000782:Aneuploidy; D000818:Animals; D001230:Aspergillus / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity; D019256:Cadmium Chloride; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D002697:Chloral Hydrate / Q000633:toxicity; D002712:Chlorides / Q000633:toxicity; D003078:Colchicine / Q000633:toxicity; D003975:Diazepam / Q000633:toxicity; D004464:Econazole / Q000633:toxicity; D004785:Environmental Pollutants / Q000633:toxicity*; D005060:Europe; D005062:European Union; D006873:Hydroquinones / Q000633:toxicity; D008322:Mammals; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011739:Pyrimethamine / Q000633:toxicity; D012486:Salmonella typhimurium / Q000187:drug effects; D013827:Thiabendazole / Q000633:toxicity; D013849:Thimerosal / Q000633:toxicity; D014747:Vinblastine / Q000633:toxicity
D002712:Chlorides; D004785:Environmental Pollutants; D006873:Hydroquinones; D009153:Mutagens; D002104:Cadmium; D013849:Thimerosal; D002697:Chloral Hydrate; D014747:Vinblastine; D004464:Econazole; D019256:Cadmium Chloride; D013827:Thiabendazole; D003975:Diazepam; D003078:Colchicine; C031927:hydroquinone; D011739:Pyrimethamine