[Hyperthyroidism caused by inadequate TSH secretion].
At 5 years of age inappropriate thyrotropin secretion was diagnosed in a girl now 11 years old. She had clinical signs of hyperthyroidism, and circulating thyroid hormones were elevated, but the TSH-level was within normal range. There was no evidence of a pituitary tumor. Therapy with bromocriptine, dexamethasone, and D-thyroxine had no measurable effect. The treatment with methimazole led to normal levels of circulating thyroid hormones, however, the TSH-level increased and the thyroid gland became diffusely enlarged. By the administration of 3,5,3'-triiodothyroacetic acid (TRIAC) (at present 20 micrograms/kg body weight) the TSH-level was lowered and a long-term remission of hyperthyroidism was achieved.
Zass
R
R
Universitäts-Kinderklinik Düsseldorf.
Steindor
U
U
Wendel
U
U
D013956:Antithyroid Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000188:drug therapy; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone; D014284:Triiodothyronine / Q000008:administration & dosage / Q000031:analogs & derivatives
D013956:Antithyroid Agents; D013963:Thyroid Hormones; D014284:Triiodothyronine; C010642:3,3',5-triiodothyroacetic acid; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin