title: Synthesis of 9E- and 9Z-locked retinoic acid analogs as ligands for RAR and RXR.
abstract: New retinoic acid (RA) analogs 9E-locked-RA 3 and 9Z-locked-RA 4 were synthesized from dithiane 6 and beta-cyclocitral 13, respectively. Both analogs behaved as agonistic ligands for a mixture of retinoic acid receptor (RAR) and retinoid X receptor (RXR).
authors.affiliation: Kobe Pharmaceutical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Katsuta
authors.forename: Y
authors.initials: Y
authors.lastname: Aoyama
authors.forename: H
authors.initials: H
authors.lastname: Osone
authors.forename: A
authors.initials: A
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Uchiyama
authors.forename: T
authors.initials: T
authors.lastname: Kitamoto
authors.forename: S
authors.initials: S
authors.lastname: Masushige
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Ito
mesh_terms: D015500:Chloramphenicol O-Acetyltransferase / Q000096:biosynthesis; D002851:Chromatography, High Pressure Liquid; D018168:Receptors, Retinoic Acid / Q000819:agonists*; D047488:Retinoid X Receptors; D014157:Transcription Factors / Q000819:agonists*; D014158:Transcription, Genetic / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D014157:Transcription Factors; D014212:Tretinoin; D015500:Chloramphenicol O-Acetyltransferase