title: Simulation study on effects of channel noise on differential conduction at an axon branch.
abstract: Effects of membrane channel noise (random opening and closing of ion channels) are studied on spike conduction at a branching point on an axon. Computer simulation is done on the basis of a stochastic version of the Hodgkin-Huxley cable model, into which the channel noise is incorporated. It is shown that the channel noise makes conduction of spikes into daughter branches random; spikes randomly succeed or fail in conduction into daughter branches. The conduction is then randomly differential even though the forms and properties of daughter branches are the same. The randomness is considerable when the radius of an axon is small (approximately 1 microns).
authors.affiliation: Information and Computer Science Laboratory, Faculty of Education, Kagawa University, Takamatsu, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Horikawa
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D003198:Computer Simulation; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000502:physiology*; D008433:Mathematics; D008959:Models, Neurological; D009431:Neural Conduction
chemical_list: D007473:Ion Channels