title: Deletion of chromosome 11 and of 14q sequences in neuroblastoma.
abstract: Restriction fragment length polymorphism (RFLP) analysis carried out on 45 primary neuroblastomas showed deletion of chromosome 11 sequences in 12 of 37 (32%) informative cases. Both 11p and 11q probes were informative in seven tumors; loss of all of chromosome 11, of only 11p sequences, and of only 11q sequences was observed in 4, 1, and 2 tumors, respectively. A cytogenetic abnormality involving translocation of chromosome arm 11q to chromosome arm 1p was observed in a primary tumor. Deletion of 14q was observed in 6 of 27 (22%) informative cases. Deletion of chromosome 11 but not 14q may correlate with regional and metastatic disease. These results suggest a possible role for sequences localized to chromosome 11 and to 14q in the development and/or progression of neuroblastoma.
authors.affiliation: Division of Hematology-Oncology, Childrens Hospital Los Angeles, CA 90027.
authors.forename: E S
authors.initials: ES
authors.lastname: Srivatsan
authors.forename: K L
authors.initials: KL
authors.lastname: Ying
authors.forename: R C
authors.initials: RC
authors.lastname: Seeger
mesh_terms: D000367:Age Factors; D000483:Alleles; D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D016259:Genes, myc; D006801:Humans; D007621:Karyotyping; D009447:Neuroblastoma / Q000235:genetics* / Q000473:pathology; D012150:Polymorphism, Restriction Fragment Length