Rapid gas chromatographic assay of diazinon: application to the study of diazinon kinetics in rats.
A rapid method was developed for the determination of diazinon in plasma using gas chromatography with electron-capture detection (GC-ECD). Following a single extraction with hexane from 100 microliters of plasma, diazinon was quantitated on a 3% OV-17 column. The detection limit was 10 ng/ml and linearity was obtained in the range of 25 ng/ml-2500 ng/ml. The applicability of the assay to single-dose kinetics in rats is illustrated.
Wu
H X
HX
Poisons Centre, INSERM U80, Alexis Carrel Faculty of Medicine, Lyon, France.
Evreux-Gros
C
C
Descotes
J
J
D000818:Animals; D002849:Chromatography, Gas / Q000379:methods*; D003976:Diazinon / Q000097:blood* / Q000493:pharmacokinetics; D004583:Electrons; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results
D003976:Diazinon