title: Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.
abstract: Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.
authors.affiliation: McArdie Laboratory, University of Wisconsin, Madison 53706.
authors.forename: H M
authors.initials: HM
authors.lastname: Temin
mesh_terms: D014644:Genetic Variation; D009154:Mutation; D012367:RNA, Viral / Q000096:biosynthesis*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D011995:Recombination, Genetic; D012190:Retroviridae / Q000502:physiology*; D017384:Sequence Deletion; D013698:Templates, Genetic; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase