N-methyl-N-nitrosourea evidences cell cycle associated transient sequences in hepatic replicating DNA.
Experiments of molecular hybridization were carried out with the aim of singling out DNA sequences which might be important in the hepatocarcinogenic action of N-methyl-N-nitrosourea. Results were obtained suggesting the synthesis of transitory DNA sequences during compensatory cell proliferation.
Kanduc
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Department of Biochemistry and Molecular Biology, Faculty of Science, University of Bari, Italy.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D004247:DNA / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects*; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D008745:Methylation; D008770:Methylnitrosourea / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008770:Methylnitrosourea; D004247:DNA