The insulin-like growth factor-I/binding protein axis: physiology, pathophysiology and therapeutic manipulation.
Insulin-like growth factor-I (IGF-I) is a single-chain polypeptide which has multiple metabolic actions and effects on the differentiation and proliferation of a wide variety of cell types. IGF-I has endocrine, paracrine and autocrine actions and is bound in the circulation to a complex system of binding proteins which alter its bioavailability and activity. Thus its physiology is complex and is altered in a number of pathological states. This review will discuss these states and the actual and proposed therapeutic applications of recombinant human IGF-I (rhIGF-I).
Langford
K S
KS
Academic Department of Medicine, King's College School of Medicine and Dentistry, London, UK.
Miell
J P
JP
D000328:Adult; D002352:Carrier Proteins / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D002648:Child; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000628:therapy; D004392:Dwarfism / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D011247:Pregnancy
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I