Effects of glucosinolate breakdown products on the hepatic biotransformation system in male rats.
The effects of 5-vinyloxazolidine-2-thione (VOT), 1-cyano-3-butene (CYB) and various isothiocyanates on parameters of hepatic phase I and phase II biotransformation were investigated in male rats after oral treatment for 3 consecutive days. The compounds with the exception of CYB caused increases in liver weight and glutathione S-transferase activity. Cytochrome P-450 level and monooxygenase activities were decreased by the isothiocyanates and CYB. Administration of VOT resulted in contrasting response of monooxygenases: reduced aminopyrine N-demethylation and enhanced aniline hydroxylation. Possible mechanisms were discussed.
Ozierenski
B
B
Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, Bundesrepublik Deutschland.
Plass
R
R
Lewerenz
H J
HJ
D000475:Alkenes / Q000494:pharmacology; D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005961:Glucosinolates / Q000378:metabolism* / Q000494:pharmacology; D005982:Glutathione Transferase / Q000378:metabolism; D017879:Isothiocyanates; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010080:Oxazoles / Q000494:pharmacology; D023303:Oxazolidinones; D051381:Rats; D017208:Rats, Wistar; D013861:Thiocyanates / Q000494:pharmacology
D000475:Alkenes; D013956:Antithyroid Agents; D005961:Glucosinolates; D017879:Isothiocyanates; D009570:Nitriles; D010080:Oxazoles; D023303:Oxazolidinones; D013861:Thiocyanates; C037152:isothiocyanic acid; C080516:1-cyano-3-butene; C004333:goitrin; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase