title: Treatment of experimental endocarditis due to multidrug resistant Enterococcus faecium with ciprofloxacin and novobiocin.
abstract: The effectiveness of ciprofloxacin and/or novobiocin therapy was assessed for experimental endocarditis caused by three strains of Enterococcus faecium resistant to ampicillin, vancomycin, and aminoglycosides. Rabbits with endocarditis caused by two of the strains had a significant decrease in bacterial counts in vegetations when treated with both antibiotics. Further studies using combination therapy with ciprofloxacin plus novobiocin for multidrug resistant strains of E. faecium are warranted.
authors.affiliation: Department of Medicine (111E), Brooklyn Veterans Administration Medical Center, New York 11209.
authors.forename: J M
authors.initials: JM
authors.lastname: Quale
authors.forename: D
authors.initials: D
authors.lastname: Landman
authors.forename: N
authors.initials: N
authors.lastname: Mobarakai
mesh_terms: D000818:Animals; D002939:Ciprofloxacin / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D016984:Enterococcus faecium / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D009675:Novobiocin / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D009675:Novobiocin; D002939:Ciprofloxacin