Genetic susceptibility in familial multiple sclerosis not linked to the myelin basic protein gene.
The myelin basic protein (MBP) gene is a candidate locus for disease susceptibility in familial multiple sclerosis. Amplification of a polymorphic tetranucleotide repeat region immediately 5' to MBP exon 1 demonstrated the presence of eight different alleles among members of 14 multiplex multiple sclerosis families (36 affected individuals). Linkage analysis was performed with autosomal dominant and autosomal recessive models, normal individuals with abnormal magnetic resonance scans being scored as either unknown or affected. Cumulative LOD scores were negative for both models of inheritance. The results do not demonstrate linkage between the MBP gene region and multiple sclerosis.
Rose
J
J
Neurovirology Research Laboratory, VAMC, Salt Lake City, UT 84148.
Gerken
S
S
Lynch
S
S
Pisani
P
P
Varvil
T
T
Otterud
B
B
Leppert
M
M
D000483:Alleles; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA; D004198:Disease Susceptibility; D005787:Gene Frequency; D005799:Genes, Dominant / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008126:Lod Score; D008279:Magnetic Resonance Imaging; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D004676:Myelin Basic Protein / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D015995:Prevalence; D012307:Risk Factors
D004676:Myelin Basic Protein; D004247:DNA