CD40 ligand is functionally expressed on human eosinophils.
CD40 ligand (CD40L), a surface molecule which can be expressed by T cells, mast cells and basophils, has been shown to be involved in the control of B cell proliferation, immunoglobulin class switching as well as in the activation of monocytes and T cells. We demonstrate that CD40L can also be expressed constitutively by eosinophils from an hypereosinophilic patient or, upon activation, by the eosinophilic cell line EOL-3 and normal blood eosinophils. Eosinophils were able to induce, in conjunction with IL-4, CD40L-dependent B cell proliferation in vitro. These results suggest that CD40L could play a role in the inflammatory processes during which eosinophil infiltration and activation are observed.
Gauchat
J F
JF
Glaxo Institute for Molecular Biology, Plan les Ouates/Geneva, Switzerland.
Henchoz
S
S
Fattah
D
D
Mazzei
G
G
Aubry
J P
JP
Jomotte
T
T
Dash
L
L
Page
K
K
Solari
R
R
Aldebert
D
D
D001402:B-Lymphocytes / Q000276:immunology; D015152:Blotting, Northern; D023201:CD40 Ligand; D002460:Cell Line; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis
D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D023201:CD40 Ligand