title: [The interconnection between the activity of carboxypeptidase N and angiotensin-converting enzyme].
abstract: Inhibition of the angiotensin-converting enzyme by guanidino-ethylmercaptosuccinic acid, a highly specific inhibitor of carboxypeptidase H, and inhibition of carboxypeptidase H by captopril, a highly specific inhibitor of the angiotensin-converting enzyme, in vivo were studied. Guanidinoethylmercaptosuccinic acid and captopril had no effect either on the angiotensin-converting enzyme or the carboxypeptidase H activities in vitro. The putative mechanisms of the inhibitors effects of the enzyme activity are discussed.
authors.forename: A N
authors.initials: AN
authors.lastname: Vernigora
authors.forename: N N
authors.initials: NN
authors.lastname: Nikishin
authors.forename: M T
authors.initials: MT
authors.lastname: Gengin
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D013386:Succinates / Q000494:pharmacology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D013386:Succinates; C022014:guanidinoethylmercaptosuccinic acid; D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; D043423:Carboxypeptidase H