[Studies on the basophil histamine releasability in allergic rhinitis].
Observing the basophil releasability of 17 patients with allergic rhinitis and 14 nonatopic subjects stimulated with house dust mite and concanavalin A (ConA), we found that the histamine release was much higher in patients with allergic rhinitis than in normal controls and that no positive correlation was found between the histamine release rate and the serum total IgE. This result suggests that the enhanced basophil releasability might be an important factor in allergic disorders, and might contribute to a means for the differentiation between allergic and non-allergic disorders.
Shen
J X
JX
Union Hospital, Tongji Medical University, Wuhan.
D000328:Adult; D000818:Animals; D001491:Basophils / Q000378:metabolism*; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008925:Mites; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000473:pathology
D003208:Concanavalin A; D007073:Immunoglobulin E