Liposomal amphotericin B for postoperative Aspergillus fumigatus endocarditis.
A 10-month-old infant girl presented with Aspergillus fumigatus endocarditis localized to a Gore-Tex patch used as part of the repair for double-outlet right ventricle. A new liposomal preparation of amphotericin B combined with surgical vegectomy resulted in a successful outcome with no evidence of disease recurrence at 15 months' follow-up. Echocardiography provided an optimal modality for ongoing evaluation of therapeutic outcome.
Hosking
M C
MC
Division of Cardiology, Childrens Hospital of Eastern Ontario, Ottawa, Canada.
MacDonald
N E
NE
Cornel
G
G
D000666:Amphotericin B / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D003131:Combined Modality Therapy; D003646:Debridement; D004310:Double Outlet Right Ventricle / Q000601:surgery*; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D008081:Liposomes; D011183:Postoperative Complications / Q000188:drug therapy* / Q000601:surgery
D008081:Liposomes; D000666:Amphotericin B