Chromosomal aberrations in peripheral blood lymphocytes of breast cancer patients prior to any therapy.
In a study comprised of 53 breast cancer patients, chosen for determining the cytogenetic damage to peripheral blood lymphocytes (PBL) due to cancer therapy, eleven patients revealed chromosomal abnormalities in 3.18% of cells prior to any such therapy. Age matched controls showed 0.18% abnormal cells. Statistical analysis of the abnormal cells in patients prior to therapy and normal controls revealed significant values at 1% level (p < 0.01). The factors causing "chromosome instability" causing chromosome breakage or whether any clastogenic metabolites produced by the tumor itself is triggering neoplastic transformation are discussed.
Udayakumar
A M
AM
Department of Pathology, Kidwai Memorial Institute of Oncology, Karnataka, India.
Bhargava
M K
MK
D001943:Breast Neoplasms / Q000097:blood / Q000235:genetics*; D002869:Chromosome Aberrations / Q000097:blood*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D012016:Reference Values