title: Localization of the human CD59 gene by fluorescence in situ hybridization and pulsed-field gel electrophoresis.
abstract: We have localized the human CD59 gene encoding a membrane protein that inhibits cell lysis by the membrane-attack complex of the homologous complement system. Using chromosomal in situ suppression hybridization and pulsed-field gel electrophoresis, we mapped this gene to chromosome 11p13, distal to the breakpoint of acute T-cell leukemia and proximal to the locus of the Wilms' tumor gene on a 30-kb SacII fragment.
authors.affiliation: Institute of Immunology and Serology, Medical Faculty of Mannheim, FRG.
authors.forename: B
authors.initials: B
authors.lastname: Heckl-Ostreicher
authors.forename: S
authors.initials: S
authors.lastname: Ragg
authors.forename: M
authors.initials: M
authors.lastname: Drechsler
authors.forename: H
authors.initials: H
authors.lastname: Scherthan
authors.forename: B
authors.initials: B
authors.lastname: Royer-Pokora
mesh_terms: D015703:Antigens, CD / Q000235:genetics*; D018957:CD59 Antigens; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins / Q000235:genetics*; D015183:Restriction Mapping
chemical_list: D015703:Antigens, CD; D018957:CD59 Antigens; D008562:Membrane Glycoproteins