title: Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601 to 1300 grams at birth. The Members of the National Institute of Child Health and Human Development Neonatal Research Network.
abstract: OBJECTIVE
  To determine whether the introduction of surfactant therapy was associated with decreased mortality for high-risk preterm neonates weighing 601 to 1300 g at birth.
  
  
  METHODS
  Before-after observational study.
  
  
  METHODS
  Eight tertiary care neonatal intensive care units participating in the National Institute of Child Health and Human Development Neonatal Research Network.
  
  
  METHODS
  The outcomes for neonates with birth weight 601 to 1300 g admitted in the 2 years before surfactants became available (n = 2780) were compared with those of neonates admitted in the year beginning 2 months after surfactants became available (n = 1413).
  
  
  METHODS
  The primary outcome measure was in-hospital mortality; secondary outcome measures included durations of assisted ventilation, length of hospitalization, and neonatal morbidity.
  
  
  RESULTS
  Forty percent of neonates in the postsurfactant group received surfactant (range 28% to 69% at the centers). Mortality decreased from 27.8% before to 19.9% after surfactant therapy was introduced (Mantel-Haenszel chi 2 = 31.4, P = .001). The adjusted odds ratio for mortality after surfactants became available was 0.73 (95% confidence interval 0.55 to 0.95). The duration of assisted ventilation and length of hospitalization increased after surfactants were introduced (P = .0001 for both outcomes).
  
  
  CONCLUSIONS
  Mortality for neonates weighing 601 to 1300 g decreased after surfactant therapy was introduced, suggesting that the efficacy of surfactants demonstrated in randomized controlled trials will translate into effectiveness in routine clinical care.
authors.affiliation: Dept of Pediatrics, University of Vermont College of Medicine, Burlington 05405.
authors.forename: J D
authors.initials: JD
authors.lastname: Horbar
authors.forename: E C
authors.initials: EC
authors.lastname: Wright
authors.forename: L
authors.initials: L
authors.lastname: Onstad
mesh_terms: D005260:Female; D006801:Humans; D007226:Infant Mortality / Q000639:trends*; D007231:Infant, Newborn; D007234:Infant, Premature; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D017063:Outcome Assessment, Health Care; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy / Q000401:mortality; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D011663:Pulmonary Surfactants