title: Interaction of selenium with copper, silver, and gold salts. Electron microprobe study.
abstract: The interaction of selenium with elements of group 1b of the periodic system, i.e. copper, silver, and gold was studied. Electron probe microanalysis was used to detect elements in intracellular organelles. Administration of copper, silver, or gold salts (the latter being used in chrysotherapy) showed that these elements were concentrated in the lysosomes of the liver or kidney in the presence of sulfur. Silver salts were also precipitated in glomerular basement membranes. The action of selenium enhances this intralysosomal process of concentration and precipitation. Sulfur and selenium are detected in the lysosome and this makes identification of the precipitate difficult. The action of selenium, which consists in removing toxic elements from the systemic circulation and concentrating them in the lysosomes, is in most cases beneficial for the organism. This mechanism, which has already been studied for arsenic, is extended in this study to other elements.
authors.affiliation: INSERM, SC27, CNRS Centre of Microanalysis Applied to Biology, Laboratory of Biophysics, Faculty of Medicine, Creteil, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Berry
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Galle
mesh_terms: D000818:Animals; D003300:Copper / Q000032:analysis*; D004577:Electron Probe Microanalysis; D006046:Gold / Q000032:analysis*; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D008247:Lysosomes / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000378:metabolism*; D012834:Silver / Q000032:analysis*
chemical_list: D012834:Silver; D006046:Gold; D003300:Copper; D012643:Selenium