title: The role of unconventional alloantigens in interstitial and vascular rejection after renal transplantation.
abstract: Lymphocytes have been used as the classic target cells to measure donor specific alloreactivity before and after renal transplantation. This was based on the concept that during rejection after kidney transplantation graft cells were recognized only because of sharing of alloantigens with lymphoid cells. There is, however, sufficient evidence to suggest that tissue specific recognition of proximal tubular cells and graft endothelial cells can occur by allospecific T cells and IgG antibodies, respectively. The antigens involved have not yet been well characterized, but seem to be of relevance in the pathogenesis of both interstitial and vascular rejection. Identification of the antigens involved may lead to more appropriate matching strategies.
authors.affiliation: Department of Nephrology, State University Hospital Leiden, The Netherlands.
authors.forename: F J
authors.initials: FJ
authors.lastname: van der Woude
authors.forename: E
authors.initials: E
authors.lastname: Schrama
authors.forename: L A
authors.initials: LA
authors.lastname: van Es
authors.forename: F J
authors.initials: FJ
authors.lastname: Claas
authors.forename: M R
authors.initials: MR
authors.lastname: Daha
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000276:immunology; D006084:Graft Rejection; D006801:Humans; D007519:Isoantigens / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology*; D007687:Kidney Tubules, Proximal / Q000276:immunology
chemical_list: D007519:Isoantigens