Involvement of an axonal reflex in IgE-mediated inflammation in mouse skin.
A neurogenic component of IgE-mediated inflammation was demonstrated in mice by footpad denervation. Footpad swelling was reduced 26% following sciatic nerve transection, but unaffected by rhizotomy or spinal nerve transection. These data provide in vivo evidence that an axonal reflex is involved in IgE-mediated inflammation and completed distal to the cell bodies of the sensory neurons located in the lumbar spinal ganglia. Furthermore, depletion of neuropeptides with capsaicin also reduced IgE-mediated swelling by 26%, indicating that unmyelinated axons are involved in the neurogenic component of IgE-mediated inflammation.
Miller
G W
GW
Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.
Liuzzi
F J
FJ
Ratzlaff
R E
RE
D000818:Animals; D001369:Axons / Q000502:physiology*; D003714:Denervation; D005260:Female; D007073:Immunoglobulin E / Q000502:physiology*; D007249:Inflammation / Q000209:etiology*; D051379:Mice; D009412:Nerve Fibers / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D012018:Reflex; D012584:Sciatic Nerve / Q000502:physiology
D009479:Neuropeptides; D007073:Immunoglobulin E