title: Aspirin and anticonvulsant interaction.
abstract: Aspirin (360 mg/kg, po) per se had anticonvulsant activity in MES model. No effect was observed at lower doses and in other models. Aspirin 216 mg/kg, po (a subanticonvulsant dose) protected animals, receiving subanticonvulsant doses of phenytoin, phenobarbitone and carbamazepine against MES.
authors.affiliation: Department of Pharmacology, Jawaharlal Nehru Medical College, Belgaum.
authors.forename: R S
authors.initials: RS
authors.lastname: Wali
authors.forename: P A
authors.initials: PA
authors.lastname: Patil
mesh_terms: D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004357:Drug Synergism; D004597:Electroshock / Q000009:adverse effects; D005260:Female; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology / Q000627:therapeutic use*; D010672:Phenytoin / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012640:Seizures / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D002220:Carbamazepine; D010672:Phenytoin; D001241:Aspirin; D010634:Phenobarbital