Enhancement of phorbol ester-induced production of tumor necrosis factor-alpha by 2,6-dimethylphenylphthalimide.
The effect of phenyl- and benzylphthalimide analogs on tumor necrosis factor (TNF)-alpha production by a human leukemia cell line, HL-60, stimulated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was investigated. Though non-substituted phenyl- and benzyl-phthalimide had no effect on TNF-alpha production after TPA-induction, introduction of methyl group(s) onto the phenyl group resulted in the appearance of potent enhancing activity on TNF-alpha production.
Shibata
Y
Y
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Sasaki
K
K
Nishimura
K
K
Hashimoto
Y
Y
Iwasaki
S
S
D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D010797:Phthalimides / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D014992:Xylenes / Q000494:pharmacology*
D010797:Phthalimides; D014409:Tumor Necrosis Factor-alpha; D014992:Xylenes; C092905:2,6-dimethylphenylphthalimide; D013755:Tetradecanoylphorbol Acetate