Microtubule-associated proteins tau and amyloid P component in Alzheimer's disease.
The localization of the intracerebral microtubule-associated proteins tau (MAP-tau) has been compared to that of amyloid P component (AP), an extracerebral protein, by single- and double-antigen immunohistochemistry in neurofibrillary tangles of Alzheimer's brains. The results show that, individually, MAP-tau and AP may be observed in all stages of neurofibrillary tangle (NFT) formation. However, NFT labeled by MAP-tau and those labeled by AP largely do not overlap in their distribution. Furthermore, within the few NFT double-labeled by MAP-tau and AP, there was an inverse relationship between the immunoreactivity to MAP-tau and to AP. It is suggested that MAP-tau and AP are incorporated at different times into NFT and that this difference in the timing of NFT expression of these 2 proteins may be useful in the study of progressive NFT formation.
Duong
T
T
Indiana University School of Medicine, Terre Haute Center for Medical Education, Terre Haute 47809.
Doucette
T
T
Zidenberg
N A
NA
Jacobs
R W
RW
Scheibel
A B
AB
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000378:metabolism; D000683:Serum Amyloid P-Component / Q000276:immunology / Q000378:metabolism*; D013373:Substance P / Q000276:immunology / Q000378:metabolism; D016875:tau Proteins / Q000276:immunology / Q000378:metabolism*
D000683:Serum Amyloid P-Component; D016875:tau Proteins; D013373:Substance P