title: Sister-chromatid exchange: second report of the Gene-Tox Program.
abstract: This paper reviews the ability of a number of chemicals to induce sister-chromatid exchanges (SCEs). The SCE data for animal cells in vivo and in vitro, and human cells in vitro are presented in 6 tables according to their relative effectiveness. A seventh table summarizes what is known about the effects of specific chemicals on SCEs for humans exposed in vivo. The data support the concept that SCEs provide a useful indication of exposure, although the mechanism and biological significance of SCE formation still remain to be elucidated.
authors.affiliation: Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94551.
authors.forename: J D
authors.initials: JD
authors.lastname: Tucker
authors.forename: A
authors.initials: A
authors.lastname: Auletta
authors.forename: M C
authors.initials: MC
authors.lastname: Cimino
authors.forename: K L
authors.initials: KL
authors.lastname: Dearfield
authors.forename: D
authors.initials: D
authors.lastname: Jacobson-Kram
authors.forename: R R
authors.initials: RR
authors.lastname: Tice
authors.forename: A V
authors.initials: AV
authors.lastname: Carrano
mesh_terms: D002478:Cells, Cultured; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D012854:Sister Chromatid Exchange
chemical_list: D009153:Mutagens