title: Synthesis and biological activity of five-coordinate platinum(II) complexes including organotin fragments.
abstract: The synthesis and characterization of two five-coordinate platinum(II) complexes of general formula [PtCl(SnMe(n)Cl3-n)(2,9-Me2-1,10-phenanthroline) (diethylfumarate)] (n = 1, 2) are described. The bimetallic species were tested on the neuroblastoma cell line SK-N-BE and a considerable inhibition of cellular proliferation was detected; the bimetallic species were also able to induce neuronal differentiation, as did retinoic acid, a well-known neuroblastoma differentiating agent.
authors.affiliation: Dipartimento di Chimica Organica e Biologica, Università di Napoli Federico II, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Carpinelli
authors.forename: S
authors.initials: S
authors.lastname: Bartolucci
authors.forename: F
authors.initials: F
authors.lastname: Ruffo
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D009447:Neuroblastoma; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D009944:Organoplatinum Compounds; D009947:Organotin Compounds