[The spectrum of the anticonvulsant action of morfolid ].
The albino experiments have shown that morpholide has an anticonvulsant effect in electroshock-, corazole-, thiosemicarbazide-, bicuculline-, strychnine-, arecoline-, nicotine-, tremorine-induced convulsions and tremors. The agent has a wider range of pharmacological effects than phenobarbital. There is a higher anticonvulsant effect of morpholide combined with phenobarbital, hexamidine and diazepam. It is suggested that GABA-ergic mechanisms contribute to the anticonvulsant action of morpholide.
Rudometova
E V
EV
Popova
N A
NA
Kolla
V E
VE
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009025:Morpholines / Q000627:therapeutic use* / Q000633:toxicity; D010634:Phenobarbital / Q000627:therapeutic use / Q000633:toxicity; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D014202:Tremor / Q000139:chemically induced / Q000188:drug therapy
D000927:Anticonvulsants; D009025:Morpholines; D010634:Phenobarbital