title: Phenoxyethanol is effective topical therapy of gram-negative cellulitis in neutropenic patients.
abstract: In neutropenic patients cellulitis caused by Gram-negative organisms may prove difficult to control and cause considerable tissue damage. Phenoxyethanol has activity against a range of bacteria, including Pseudomonas aeruginosa, and is absorbed by intact skin. Three severely neutropenic patients are described in whom cellulitis failed to respond to appropriate intravenous antibiotics. However the topical application of phenoxyethanol solution gave prompt local control. This cheap and nontoxic agent may give dramatic improvement in this difficult clinical situation.
authors.affiliation: Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, UK.
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
authors.forename: R
authors.initials: R
authors.lastname: Powles
authors.forename: K
authors.initials: K
authors.lastname: Rege
authors.forename: J
authors.initials: J
authors.lastname: Treleaven
authors.forename: D
authors.initials: D
authors.lastname: Catovsky
authors.forename: J
authors.initials: J
authors.lastname: Mehta
authors.forename: B
authors.initials: B
authors.lastname: Jameson
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002481:Cellulitis / Q000188:drug therapy*; D002675:Child, Preschool; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications*; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D010626:Phenylethyl Alcohol