title: Racial differences in maternal serum human chorionic gonadotropin and unconjugated oestriol levels.
abstract: We assayed maternal serum samples from 134 black and 268 white women from 16 to 18 weeks of gestation for intact human chorionic gonadotropin (hCG), and unconjugated oestriol (uE3). Serum from women with high (> or = 2.5 MOMs) or low (risk for Down syndrome > or = 1/365) maternal serum alpha-fetoprotein (MSAFP) levels were excluded. After correcting for maternal weight, we found that median hCG levels were 16 per cent higher in black women but uE3 levels were not significantly different. These results confirm three other studies for hCG and one study for uE3. Corrections are recommended for both maternal serum hCG and AFP before calculating the risk for Down syndrome in black women.
authors.affiliation: Department of Psychiatry, University of California, Los Angeles 90024.
authors.forename: P
authors.initials: P
authors.lastname: Kulch
authors.forename: S
authors.initials: S
authors.lastname: Keener
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: B F
authors.initials: BF
authors.lastname: Crandall
mesh_terms: D044383:Black People; D001835:Body Weight; D006063:Chorionic Gonadotropin / Q000097:blood*; D004314:Down Syndrome / Q000175:diagnosis; D004958:Estradiol / Q000097:blood*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D012307:Risk Factors; D044465:White People; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D004958:Estradiol