title: Recombinant human granulocyte colony-stimulating factor: an overview.
abstract: Recombinant granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor used for the reduction or prevention of cyclic neutropenia in cancer patients. Neutropenia is a major factor contributing to infection, morbidity, and mortality. Neutropenia also reduces the dosage of cytotoxic agents and often interrupts the course of treatment. The recent development of cloning G-CSF has been a major advancement in treating cyclic neutropenia. This article focuses on the mechanism of action, pharmacokinetics, and the clinical applications of G-CSF.
authors.forename: G
authors.initials: G
authors.lastname: Koloc
authors.forename: K
authors.initials: K
authors.lastname: Scharnweber
mesh_terms: D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use; D006410:Hematopoiesis; D006801:Humans; D009732:Nursing Care / Q000379:methods; D012051:Reimbursement Mechanisms
chemical_list: D016179:Granulocyte Colony-Stimulating Factor