title: A diterpene from Mikania obtusata active on Trypanosoma cruzi.
abstract: The diterpene ent-kaur-16-en-19-oic acid (1) was identified as the trypanocidal component of the ethanolic extract from Mikania obtusata D. C. (Asteraceae). This compound presents an IC50 of 0.5 mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis).
authors.forename: T M
authors.initials: TM
authors.lastname: Alves
authors.forename: P P
authors.initials: PP
authors.lastname: Chaves
authors.forename: L M
authors.initials: LM
authors.lastname: Santos
authors.forename: T J
authors.initials: TJ
authors.lastname: Nagem
authors.forename: S M
authors.initials: SM
authors.lastname: Murta
authors.forename: I P
authors.initials: IP
authors.lastname: Ceravolo
authors.forename: A J
authors.initials: AJ
authors.lastname: Romanha
authors.forename: C L
authors.initials: CL
authors.lastname: Zani
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D051379:Mice; D010944:Plants / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D004224:Diterpenes; D014344:Trypanocidal Agents