[Different shifts in the plasma corticosterone content depending on the dose and administration route of melatonin].
The changes in plasma corticosterone levels were studied when the pineal hormone melatonin was administered in various doses and by routes in rat experiments. Its single administration in a median (1 mg/kg) and high (10 mg/kg) doses caused enhanced corticosteroid secretion. On the contrary, there were lover blood levels of corticosterone when melatonin was chronically used in a low dose of 0.1 mg/kg. The value of inhibitory pineal-adrenocortical relationships was studied for melatonin pharmacology.
Arushanian
E B
EB
El'bek'ian
K S
KS
D000818:Animals; D003345:Corticosterone / Q000097:blood* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D051381:Rats; D013050:Spectrometry, Fluorescence; D018709:Statistics, Nonparametric; D013997:Time Factors
D008550:Melatonin; D003345:Corticosterone