Molecules involved in T-cell costimulation.
Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a 'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.
Jenkins
M K
MK
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455.
Johnson
J G
JG
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D015703:Antigens, CD / Q000502:physiology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D000954:Antigens, Surface; D018122:B7-1 Antigen; D018106:CD28 Antigens; D002118:Calcium / Q000502:physiology; D002455:Cell Division; D006801:Humans; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000096:biosynthesis*; D008024:Ligands; D008213:Lymphocyte Activation / Q000502:physiology*; D046911:Macromolecular Substances; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D018122:B7-1 Antigen; D018106:CD28 Antigens; D007376:Interleukin-2; D008024:Ligands; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell; D002118:Calcium