[Markers of chronic hepatitis B in children after completion of therapy with isoprinosine].
Fourteen children with chronic active hepatitis B treated with isoprinosine were followed-up for 3-8 years. In no child HBs antigen was eliminated. No seroconversion was noted in children in whom HBe antigen was eliminated. Anti-HBe antibodies were found in 11 children, including 6 children in whom they were present all the time following therapy, and 2 children in whom these antibodies reappeared after an initial elimination. These results suggest that the inhibition of hepatitis B virus replication produced by isoprinosine may be transient. Therefore, longer lasting immunomodulating therapy should be considered.
Kowalik-Mikołajewska
B
B
Kliniki Chorób Zakaźnych i Pasozytniczych Wieku Dzieciecego Instytutu Chorób Zakaźnych i Pasozytniczych AM, Warszawie.
Barszcz
T
T
Ladyzyńska
E
E
Wojnarowski
M
M
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy* / Q000276:immunology; D006511:Hepatitis B Antigens / Q000032:analysis; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007223:Infant; D007542:Inosine Pranobex / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D015415:Biomarkers; D006511:Hepatitis B Antigens; D007542:Inosine Pranobex