[The suppression of the cerebrovascular constrictor effects of malondialdehyde by GABA-ergic substances].
GABA and its cyclic derivatives, gamma-butyrolactone and pyrrolidone-2, have been ascertained to abolish and prevent the cerebral vasoconstrictor effects of malonic dialdehyde. In this respect, gamma-butyrolactone excels pyrrolidone-2 and GABA, the effects of GABA being most slight. It may be suggested that the neuroactive amino acids exhibit antioxidative effects.
Mirzoian
S A
SA
Akopian
V P
VP
Manukian
A A
AA
D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D008315:Malondialdehyde / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000975:Antioxidants; D011760:Pyrrolidinones; D008315:Malondialdehyde; D005680:gamma-Aminobutyric Acid; C028537:2-pyrrolidone; D015107:4-Butyrolactone