Prevalence of spondyloarthropathies and HLA-B27 in the native population of Chukotka, Russia.
OBJECTIVE
We sought to determine the prevalence and nature of spondyloarthropathies (SPA) and the prevalence of HLA-B27 in the native selected circumpolar population of Chukotka, Russia.


METHODS
We conducted a cross sectional study that included medical examinations and interviews of 355 of 498 (71.3%) native residents of 2 Eastern Chukotka settlements, Enmelen and Nunligran.


RESULTS
Among them were 268 Chukchas, 7 Eskimos, and 80 subjects of mixed race. There were 9 subjects (2.5%) with SPA, 3 of 7 Chukchas had ankylosing spondylitis (AS) (1.1%), 2 reactive arthritis (ReA), 2 with undifferentiated SPA. Among the mixed race persons one Chukcha-Eskimo had AS, one Eskimo-Russian had psoriatic arthritis (PsA). We found a high percentage of HLA-B27 antigen in the population, 34% in Chukcha natives and 25% in mixed race.


CONCLUSIONS
Our data complement other studies of circumpolar populations and reinforce the reported high prevalences of SPA and HLA-B27 among those populations.
Alexeeva
L
L
Department of Epidemiology and Genetics Rheumatic Diseases, Institute of Rheumatology RAMS, Moscow, Russia.
Krylov
M
M
Vturin
V
V
Mylov
N
N
Erdesz
S
S
Benevolenskaya
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000208:ethnology* / Q000276:immunology; D016918:Arthritis, Reactive / Q000208:ethnology / Q000276:immunology; D002648:Child; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D000091402:Prohibitins; D012426:Russia / Q000453:epidemiology; D013122:Spinal Diseases / Q000208:ethnology* / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000208:ethnology* / Q000276:immunology
D015796:HLA-B27 Antigen; C000717331:PHB2 protein, human; D000091402:Prohibitins