[Radioprotective effects of hypoxyradiotherapy on saliva secretion].
In radiotherapy, use of an enormous radical dose may be necessary. However, it is sometimes limited by the poor tolerance of the surrounding normal tissues. Transient systemic hypoxia induced by breathing 10.5% oxygen gas during radiotherapy may protect the normal tissues. In treating non-Hodgkin's lymphoma (NHL) involving the Waldeyer's ring, radioprotective effects of hypoxia on radiation responses of the pharyngeal mucosa and saliva secretion were observed, giving a radioprotective factor (RPF) of 1.43 in saliva quantity and 1.31 in ptyalin secretion. Other responses were milder and occurred later.
Liu
X F
XF
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
D000681:Amylases / Q000378:metabolism; D015687:Cell Hypoxia; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology / Q000532:radiotherapy*; D009092:Mucous Membrane / Q000528:radiation effects; D010614:Pharynx / Q000528:radiation effects; D011882:Radiotherapy, High-Energy; D012463:Saliva / Q000378:metabolism*; D012469:Salivary Glands / Q000378:metabolism / Q000528:radiation effects
D000681:Amylases