title: Intra-arterial digital subtraction angiography with isotonic dimeric (iodixanol) and monomeric (iohexol) nonionic contrast media: radiographic, clinical and neurophysiological evaluation.
abstract: Monomeric (iohexol 300 mg I/ml) and dimeric (iodixanol 270 mg I/ml) nonionic contrast media were compared in a double-blind, randomised, parallel group trial. Safety and efficacy of the media in intra-arterial cerebral digital subtraction angiography were evaluated by assessing adverse events, discomfort, EEG, heart rate and quality of radiodiagnostic information. Seventy-six patients underwent selective injection of the carotid and/or vertebral arteries. Both contrast media were well tolerated. No serious adverse events occurred. No effects on heart rate and EEG were evident. The arteriograms were of high quality and overall diagnostic information was optimal in 94% of the examinations. No clinically important differences between the two contrast media were found.
authors.affiliation: Department of Radiology, Leyenburg Hospital, Den Haag, The Netherlands.
authors.forename: R E
authors.initials: RE
authors.lastname: Hekster
authors.forename: H H
authors.initials: HH
authors.lastname: Morré
authors.forename: P
authors.initials: P
authors.lastname: Cleyndert
authors.forename: J
authors.initials: J
authors.lastname: Zapletal
authors.forename: L F
authors.initials: LF
authors.lastname: Sinnige
authors.forename: B
authors.initials: B
authors.lastname: Bolstad
authors.forename: Y
authors.initials: Y
authors.lastname: Keetlapper
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000009:adverse effects; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D014283:Triiodobenzoic Acids / Q000009:adverse effects; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C044834:iodixanol