title: Prenatal diagnosis and management of anterior abdominal wall defects in the west of Scotland.
abstract: An attempt was made to identify all the cases of abdominal wall defects occurring in the West of Scotland over a 7-year period to determine the current incidence, prenatal diagnosis, management, and prognosis for fetuses and neonates with abdominal wall defects. Cases were identified because they presented either for prenatal diagnosis, or to the Department of Pathology following termination or spontaneous pregnancy loss, or as neonates to the Neonatal Surgical Department. The incidence of abdominal wall defects was found to be 1 in 2500 births. Exomphalos was diagnosed before birth in 66 per cent of cases, and in 30 per cent of cases it was associated with another major abnormality. There was a 20 per cent intact survival in the cases diagnosed prenatally who had no fetal anomaly and who opted to continue with the pregnancy. Gastroschisis was diagnosed before delivery in 70 per cent of cases, and in the group who continued with the pregnancy there was an intact survival of 77 per cent. Body stalk anomalies were all diagnosed prenatally and terminated. Maternal serum alpha-fetoprotein was elevated in 89 per cent of the cases with exomphalos and in 100 per cent of the cases with gastroschisis and body stalk anomalies in which it was tested.
authors.affiliation: Department of Midwifery, Queen Mother's Hospital, Glasgow, U.K.
authors.forename: R J
authors.initials: RJ
authors.lastname: Morrow
authors.forename: M J
authors.initials: MJ
authors.lastname: Whittle
authors.forename: M B
authors.initials: MB
authors.lastname: McNay
authors.forename: P A
authors.initials: PA
authors.lastname: Raine
authors.forename: A A
authors.initials: AA
authors.lastname: Gibson
authors.forename: J
authors.initials: J
authors.lastname: Crossley
mesh_terms: D000009:Abdominal Muscles / Q000002:abnormalities* / Q000601:surgery; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D036861:Delivery, Obstetric; D005260:Female; D006554:Hernia, Umbilical / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D011247:Pregnancy / Q000097:blood; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D012606:Scotland / Q000453:epidemiology; D016216:Ultrasonography, Prenatal; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins