Dilapan tent-gemeprost regimen vs. combinations of extra-amniotic Rivanol-Laminaria/Lamicel and oxytocin for second trimester abortion.
OBJECTIVE
To compare a new regimen for second trimester abortion using Dilapan and vaginal gemeprost suppositories with extra-amniotic Rivanol instillation and oxytocin i.v. immediately or 16 h after instillation.


METHODS
A prospective study was performed in 153 women to analyze the induction-abortion interval, the use of analgesics and the complication rate. Wilcoxon's rank sum test was used for statistical evaluation.


RESULTS
The mean induction-abortion interval was significantly shorter in the Dilapan-gemeprost-treated women than in the immediate or 16-h Rivanol-oxytocin-treated women, 12.5 vs. 23.3 and 26.8 h, respectively. The 24-h cumulative abortion rate was 91% in the former group vs. 49% and 61%, respectively. The use of analgesics was less frequent among the Dilapan-gemeprost-treated women, whereas the complication rate did not differ.


CONCLUSIONS
The Dilapan-gemeprost treatment was advantageous with respect to a shorter induction-abortion interval and ease of handling. However a minority of women do not respond to this treatment and it is therefore necessary to employ alternative methods to complete the abortion in these cases.
Bokström
H
H
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Bryman
I
I
Norström
A
A
Platz-Christensen
J J
JJ
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D000028:Abortion, Induced / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000031:analogs & derivatives; D001672:Biocompatible Materials; D004975:Ethacridine; D005260:Female; D006801:Humans; D007795:Laminaria; D008278:Magnesium Sulfate; D010121:Oxytocin; D011108:Polymers; D011142:Polyvinyl Alcohol; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D011459:Prostaglandins E, Synthetic; D013997:Time Factors
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D001672:Biocompatible Materials; C034860:Lamicel; D011108:Polymers; D011459:Prostaglandins E, Synthetic; C077755:dilapan; C021182:gemeprost; D010121:Oxytocin; D008278:Magnesium Sulfate; D011142:Polyvinyl Alcohol; D000527:Alprostadil; D004975:Ethacridine