Animal models of early osteoarthritis: their use for the evaluation of potential chondroprotective agents.
Medial meniscectomy was undertaken in adult merino sheep and after 16 weeks exercise each group was administered five weekly intra-articular injections of saline, pentosan polysulphate (PPS), hyaluronic acid (HA) or a combination of PPS + HA. Gait analysis and x-rays were undertaken before and after drug treatment. At sacrifice (26 weeks), joints were examined for gross pathological and histochemical changes. Only the PPS-treated group showed an improvement in gait, with low radiological and histology scores. The HA-treated group showed similar but less significant changes to these parameters.
Ghosh
P
P
Raymond Purves Research Laboratories, University of Sydney, Royal North Shore Hospital of Sydney, St. Leonards, New South Wales, Australia.
Armstrong
S
S
Read
R
R
Numata
Y
Y
Smith
S
S
McNair
P
P
Marshall
R
R
D000818:Animals; D001175:Arthrography; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000473:pathology; D004195:Disease Models, Animal; D005684:Gait / Q000502:physiology; D006651:Histocytochemistry; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007270:Injections, Intra-Articular; D007596:Joints / Q000473:pathology; D008297:Male; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000627:therapeutic use*; D005082:Physical Exertion; D012756:Sheep; D013583:Synovial Membrane / Q000502:physiology
D010426:Pentosan Sulfuric Polyester; D006820:Hyaluronic Acid