[A neurochemical analysis of the substance P-induced reordering of the feeding behavior evoked by electrical stimulation of the lateral hypothalamus].
The substance P when administered intracerebroventricularly (15 nmol) led to a transformation of feeding elicited by threshold electrical stimulation of the lateral hypothalamus into an escape reaction in rabbits. Obsidan, Inderal (0.25 and 0.5 mg) and droperidol (0.3 mg) injected intravenously were found to restore the functional properties of the hypothalamic feeding centre. No changes in the escape reaction were observed after kalipsol (ketaminum) administration. The data obtained suggest the important role of the catecholaminergic brain structures in the mechanisms of the transformation of the functional properties of the hypothalamic feeding centre under the influence of the substance P.
Zilov
V G
VG
Patyshakuliev
A P
AP
Rogacheva
S K
SK
Ivanova
L I
LI
D000818:Animals; D004329:Droperidol / Q000494:pharmacology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D007649:Ketamine; D011433:Propranolol; D004329:Droperidol