[Effect of malonate on various aspects of hepatic metabolism].
Malonate was tested for its effects on rat hepatic metabolism of [1,4-14C]-succinic acid and [1-14C]-glycerol. The administration of malonic acid did not limit [1,4-14C]-succinate metabolism and change the rate of radioactive labelling from [1-14C]-glycerol to the total lipid fraction, as well as the fraction of phospholipids and triacylglycerides. However, there was a reduction in the use of glycerol as a precursor of higher fatty acids and cholesterol. It is suggested that the detected effect of malonate is due to its action on oxidative decarboxylation of pyruvic acid.
Davydov
V V
VV
Krisanova
N V
NV
Skorik
G V
GV
D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008314:Malonates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008314:Malonates; C030290:malonic acid