title: Granulocyte-colony stimulating factor therapy in drug-induced agranulocytosis.
abstract: Drug-induced agranulocytosis in the outpatient setting is a rare but potentially fatal adverse effect of many classes of medications. Five patients with this disorder presented to Yale-New Haven (Conn) Hospital during 1990 through 1992. Three patients treated with granulocyte-colony stimulating factor and two patients treated with routine care were studied for relevant clinical outcomes. Treatment with granulocyte-colony stimulating factor was associated with a shorter duration of neutropenia and a decreased length of hospital stay, consistent with recent case reports. Despite the high cost of the drug, treatment with granulocyte-colony stimulating factor was found to be cost-effective for patients with uncomplicated drug-induced agranulocytosis.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.
authors.forename: S
authors.initials: S
authors.lastname: Mani
authors.forename: M
authors.initials: M
authors.lastname: Barry
authors.forename: J
authors.initials: J
authors.lastname: Concato
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000380:Agranulocytosis / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor