Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B.
Staphylococcus aureus enterotoxin B (SEB) was added to explants of fetal human intestine in organ culture or administered into the lumen of fetal small intestine prior to culture. Both routes produced a massive increase in lamina propria T cells expressing V beta 3, and to a lesser extent, those expressing V beta 5 and V beta 12. SEB-activated lamina propria T cells produced interleukin-2 and interferon-gamma and T cell activation was accompanied by tissue damage, which was inhibited by FK506.
Lionetti
P
P
Department of Paediatric Gastroenterology, Medical College of St. Bartholomews Hospital, London.
Spencer
J
J
Breese
E J
EJ
Murch
S H
SH
Taylor
J
J
MacDonald
T T
TT
D000942:Antigens, Bacterial / Q000276:immunology*; D004768:Enterotoxins / Q000276:immunology*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D007421:Intestine, Small / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D009924:Organ Culture Techniques; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D016559:Tacrolimus / Q000494:pharmacology
D000942:Antigens, Bacterial; D004768:Enterotoxins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016559:Tacrolimus