Bleomycin increases amikacin and streptomycin resistance in Escherichia coli harboring transposon Tn5.
The antitumor antibiotic bleomycin acts as a transcriptional inducer of the neo-ble-str operon of the transposon Tn5, increasing the resistance level to streptomycin and amikacin in Tn5-containing Escherichia coli. The mechanism may involve a recA-independent induction mediated by DNA damage.
Blazquez
J
J
Servicio de Microbiología, Hospital Ramón y Cajal, Madrid, Spain.
Martinez
J L
JL
Baquero
F
F
D000583:Amikacin / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology*; D004249:DNA Damage; D004251:DNA Transposable Elements; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D009876:Operon / Q000187:drug effects; D010957:Plasmids; D013307:Streptomycin / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D004251:DNA Transposable Elements; D001761:Bleomycin; D000583:Amikacin; D013307:Streptomycin