title: Evidence of marked digoxin-like immunoreactivity in the human adrenal cortex: results of an immunohistochemical study.
abstract: Several lines of evidence suggest the existence, in mammalian body fluids and tissue extracts, of an as yet unidentified endogenous digitalis-like factor with potential cross-immunoreactivity with digitalis. Using anti-digoxin antibodies, we found preliminary immunohistochemical evidence of digoxin-like immunoreactivity in several human tissues. Strong reactivity was found in the adrenal cortex, which may thus represent a site of production of this endogenous factor.
authors.affiliation: CNR Institute of Clinical Physiology, Pisa, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Ghione
authors.forename: S
authors.initials: S
authors.lastname: Balzan
authors.forename: S
authors.initials: S
authors.lastname: Braus
authors.forename: U
authors.initials: U
authors.lastname: Montali
authors.forename: J
authors.initials: J
authors.lastname: Bruno
mesh_terms: D000302:Adrenal Cortex / Q000737:chemistry*; D000906:Antibodies / Q000276:immunology; D001798:Blood Proteins / Q000032:analysis* / Q000276:immunology; D002298:Cardenolides; D003429:Cross Reactions; D004077:Digoxin; D004801:Eosine Yellowish-(YS) / Q000737:chemistry; D006416:Hematoxylin / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D012503:Saponins
chemical_list: D000906:Antibodies; D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin