title: How specific is the first recognition step of homologous recombination?
abstract: The Escherichia coli RecA protein promotes homologous recognition in base triplets via non-Watson-Crick bonds that differ from those formed nonenzymically from DNA consisting of runs of purines or pyrimidines. Base substitutions reveal recognition to be permissive, consistent with a search for homology that achieves speed at the cost of precision.
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Rao
authors.forename: S K
authors.initials: SK
authors.lastname: Chiu
authors.forename: L R
authors.initials: LR
authors.lastname: Bazemore
authors.forename: G
authors.initials: G
authors.lastname: Reddy
authors.forename: C M
authors.initials: CM
authors.lastname: Radding
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D011938:Rec A Recombinases / Q000378:metabolism; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
chemical_list: C051802:triplex DNA; D004247:DNA; D011938:Rec A Recombinases