Specific changes in the M1 protein during adaptation of influenza virus to mouse.
The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M1 protein which correlated with virulence for mouse: Ala41-->Val and Thr139-->Ala.
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Biomolecular Research Institute, Parkville, Victoria, Australia.
D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000821:virology*; D005814:Genes, Viral; D009980:Influenza A virus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D016865:Reassortant Viruses / Q000235:genetics; D014763:Viral Matrix Proteins / Q000737:chemistry / Q000235:genetics*; D014774:Virulence
D014763:Viral Matrix Proteins