In vivo and in vitro expression of canine distemper viral proteins in dogs and non-domestic carnivores.
The occurrence of the nucleo-, phospho-, matrix, fusion, and hemagglutinin proteins of the canine distemper virus (CDV) was investigated immunocytochemically in the brains of 3 dogs, 6 stone martens, 1 polecat, and 1 weasel. In addition, viral protein expression was studied in primary brain cell cultures of the 3 dogs after co-cultivation with Vero cells. Immunohistochemically, only minor differences, restricted to the H-4 epitope, were noted between the various species and CDV isolates. The data presented indicate that the mustelid virus is antigenically not distinct from the canine morbillivirus.
Alldinger
S
S
Institut für Veterinär-Pathologie, Justus-Univesität Giessen, Federal Republic of Germany.
Baumgärtner
W
W
van Moll
P
P
Orvell
C
C
D000818:Animals; D000835:Animals, Wild / Q000382:microbiology*; D001921:Brain / Q000382:microbiology*; D002335:Carnivora / Q000382:microbiology*; D002525:Cerebellar Cortex / Q000382:microbiology; D004217:Distemper Virus, Canine / Q000254:growth & development / Q000302:isolation & purification*; D004285:Dogs; D000939:Epitopes; D007150:Immunohistochemistry; D009457:Neuroglia / Q000382:microbiology; D011689:Purkinje Cells / Q000382:microbiology; D014709:Vero Cells; D014764:Viral Proteins / Q000302:isolation & purification*; D014779:Virus Replication
D000939:Epitopes; D014764:Viral Proteins