title: Total i.v. anaesthesia with propofol and the laryngeal mask for orthopaedic surgery.
abstract: One hundred ASA I orthopaedic surgical patients (four randomized groups) were anaesthetized using continuous propofol and intermittent fentanyl (TIVA), with controlled ventilation via a tracheal tube in groups 1 and 2, and a laryngeal mask airway (LMA) in groups 3 and 4. Neuromuscular blockers were used in groups 1 and 3 only. There were no significant differences between groups in total anaesthetic requirements, as assessed by cardiovascular variables and movement. Coughing interfered with surgery and made controlled ventilation difficult to manage. In contrast, movement not associated with coughing did not impair surgery or ventilation. Patients in group 2 (tracheal tube, no neuromuscular blocker) required more interventions for coughing than the other groups, while patients in group 4 (LMA, no neuromuscular blocker) needed more boluses for movement than groups 1 and 3. Groups 1 and 2 (tracheal tube) had significantly higher heart rates and mean arterial pressures than groups 3 and 4 for varying periods up to 5 min after insertion of the airway management device. There was no correlation between mean arterial pressure and plasma concentrations of catecholamines related to insertion of either the tracheal tube or LMA. The LMA was found to be a highly effective device for controlled ventilation in TIVA and easier to manage than the tracheal tube in the absence of neuromuscular blockers.
authors.affiliation: Department of Anaesthesia, Groote Schuur Hospital, Observatory, Cape Town, Republic of South Africa.
authors.forename: R A
authors.initials: RA
authors.lastname: Dyer
authors.forename: R L
authors.initials: RL
authors.lastname: Llewellyn
authors.forename: M F
authors.initials: MF
authors.lastname: James
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D001794:Blood Pressure; D004837:Epinephrine / Q000097:blood; D005260:Female; D005283:Fentanyl; D006339:Heart Rate; D006801:Humans; D017214:Laryngeal Masks; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D009985:Orthopedics; D015742:Propofol; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage
chemical_list: D014673:Vecuronium Bromide; D005283:Fentanyl; D009638:Norepinephrine; D015742:Propofol; D004837:Epinephrine