Numerical aberrations, including trisomy 22 as the sole anomaly, are recurrent in follicular thyroid adenomas.
Short-term cultures from 38 follicular thyroid adenomas revealed clonal numerical and/or structural chromosomal changes in 8 tumors, nonclonal changes in 1 tumor, and only normal karyotypes in 29 tumors. Three cases had trisomy 22 as the sole anomaly. Two cases had a combination of trisomies for chromosomes 5, 7, 9, 12, and 16.
Antonini
P
P
CNRS URA 1158, Laboratoire de Cytogénétique et Génétique Oncologiques, Institut Gustave-Roussy, Villejuif, France.
Lévy
N
N
Caillou
B
B
Vénuat
A M
AM
Schlumberger
M
M
Parmentier
C
C
Bernheim
A
A
D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology; D014314:Trisomy