Mouse and human micronucleus models for assessing genotoxicity of whole foods in intervention studies.
There is an emerging need to apply classical genotoxicity assays to assess, in vivo, the carcinogenic or anti-carcinogenic potential of traditional and novel foods. The micronucleus techniques in peripheral blood erythrocytes and lymphocytes are two of the methods that have been used for assessing chromosome-damaging effects following and during dietary interventions with whole foods. The advantage of this approach stems from the practicality of the methods and the possibility of using these techniques in both human and rodent models. The potential application of these methods is illustrated by comparison of recent examples in the literature and from ongoing research.
Fenech
M
M
C.S.I.R.O. Division of Human Nutrition, Adelaide, Australia.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005502:Food / Q000633:toxicity*; D006801:Humans; D051379:Mice; D015162:Micronucleus Tests
D002273:Carcinogens