title: Amikacin levels in bronchial secretions of 10 pneumonia patients with respiratory support treated once daily versus twice daily.
abstract: In this study, concentrations of amikacin in blood and bronchial secretions of 10 patients with mechanical ventilation for acute respiratory failure due to pneumonia were measured. One-half of the patients received amikacin twice daily, and the others received once-daily administration. Concentrations in bronchial secretions of the patients treated twice daily ranged from 3 to 4 mg/liter, i.e., they were similar to those in previously published reports. Peak concentrations in bronchial secretions occurred between 3 and 4 h after the onset of infusion, and they reached 4.8 +/- 2.6 mg/liter on day 1 and 4.0 +/- 2.7 mg/liter on day 3. For the patients treated with amikacin once daily, concentrations in bronchial secretions were more than twofold higher, above 8 mg/liter for 12 h. Peak concentrations in bronchial secretions occurred between 3 and 4 h after the onset of infusion and reached 13.6 +/- 9.3 mg/liter on day 1 and 10.4 +/- 3.5 mg/liter on day 3. These concentrations are higher than the MICs for less sensitive bacterial strains, such as Acinetobacter spp. and Pseudomonas aeruginosa.
authors.affiliation: Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France.
authors.forename: C
authors.initials: C
authors.lastname: Santré
authors.forename: H
authors.initials: H
authors.lastname: Georges
authors.forename: J M
authors.initials: JM
authors.lastname: Jacquier
authors.forename: O
authors.initials: O
authors.lastname: Leroy
authors.forename: C
authors.initials: C
authors.lastname: Beuscart
authors.forename: D
authors.initials: D
authors.lastname: Buguin
authors.forename: G
authors.initials: G
authors.lastname: Beaucaire
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000583:Amikacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000378:metabolism; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000378:metabolism / Q000628:therapy
chemical_list: D000583:Amikacin