Neuropharmacological studies on identified central neurones of the snail, Helix aspersa.
Central neurones of the snail, Helix aspersa, possess both synaptic and somatic receptors to a wide range of classical transmitters and neuroactive peptides. The range of receptors and the type of response is reasonably constant for a specific neurone. This review will provide data concerning the pharmacology of acetylcholine, serotonin, dopamine, noradrenaline, octopamine, glutamate, GABA and purine receptors on identified neurones. Many of these neurones also respond to neuroactive peptides including molluscan peptides, e g, AMPMLRLamide, LSSFVRIamide, SGQSWRQGRPFamide, FMRFamide; coelenterate peptides, e g, pQGRFamide; echinoderm peptides, e g, GFNSALMFamide; and nematode peptides, e g, KNEFIRFamide, KHEYLRFamide, SDPNFLRFamide. Using this data, the pharmacological profiles of identified neurones will be summarised.
Walker
R J
RJ
Department of Physiology and Pharmacology, University of Southampton.
Chen
M L
ML
Pedder
S
S
Holden-Dye
L
L
White
A R
AR
Sharma
R
R
D000818:Animals; D004347:Drug Interactions; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009479:Neuropeptides / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology
D007473:Ion Channels; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter