title: Sodium lactate increases sympathovagal ratios in normal control subjects: spectral analysis of heart rate, blood pressure, and respiration.
abstract: We used spectral analysis of heart rate (HR), blood pressure (BP), and respiration to examine the effects of lactate on cholinergic and adrenergic influences on HR and BP variability, a technique found to be very useful in cardiovascular research. We specifically used high frequency (0.2-0.5 Hz) and midfrequency (0.07-0.15 Hz) powers to study cholinergic and adrenergic activity in nine normal control subjects before and after lactate and placebo infusions. Our results demonstrate a marked decrease in cholinergic activity and a significant increase in sympathovagal ratios of HR modulation after lactate infusions. This altered sympathovagal balance may contribute to the panicogenic effects of lactate in panic disorder patients.
authors.affiliation: Wright University School of Medicine, Dayton, OH, USA.
authors.forename: V K
authors.initials: VK
authors.lastname: Yeragani
authors.forename: K
authors.initials: K
authors.lastname: Srinivasan
authors.forename: R
authors.initials: R
authors.lastname: Pohl
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: R
authors.initials: R
authors.lastname: Balon
authors.forename: R
authors.initials: R
authors.lastname: Berchou
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004562:Electrocardiography / Q000706:statistics & numerical data; D005260:Female; D005583:Fourier Analysis; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D008297:Male; D008991:Monitoring, Physiologic; D011187:Posture; D012119:Respiration / Q000187:drug effects*; D012815:Signal Processing, Computer-Assisted; D013564:Sympathetic Nervous System / Q000187:drug effects
chemical_list: D007773:Lactates; D019344:Lactic Acid