title: Signaling for death of lymphoid cells.
abstract: The induction of programmed cell death in lymphocytes is a common response to a wide variety of physiological and pharmacological stimuli. While there is still much to be learned about the transmembrane signals that lead to programmed cell death, progress has been made in identifying new cell surface molecules (e.g. APO-1/Fas) that may regulate the physiological induction of lymphocyte death, molecules whose expression inhibits apoptosis (e.g. Bcl-2), and the antagonism of activation-induced cell death in T-cell hybridomas and thymocytes by members of the steroid receptor superfamily.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda.
authors.forename: L B
authors.initials: LB
authors.lastname: King
authors.forename: J D
authors.initials: JD
authors.lastname: Ashwell
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology*; D015551:Autoimmunity; D002118:Calcium / Q000502:physiology; D053804:Granzymes; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology; D008214:Lymphocytes / Q000166:cytology*; D051379:Mice; D008954:Models, Biological; D011493:Protein Kinase C / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis / Q000235:genetics; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D014212:Tretinoin / Q000494:pharmacology; D019014:fas Receptor
chemical_list: D000954:Antigens, Surface; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; D011965:Receptors, Glucocorticoid; D014157:Transcription Factors; D019014:fas Receptor; D014212:Tretinoin; D011493:Protein Kinase C; D053804:Granzymes; D012697:Serine Endopeptidases; C509212:GZMA protein, human; D002118:Calcium