title: Treatment of progressive outer retinal necrosis with sorivudine.
abstract: OBJECTIVE
  We examined a patient with progressive outer retinal necrosis, which is presumably caused by the varicella-zoster virus in patients with the acquired immunodeficiency syndrome.
  
  
  CONCLUSIONS
  The patient was successfully treated with a combination of intravitreal ganciclovir and oral sorivudine. Treatment for progressive outer retinal necrosis has been disappointing; both acyclovir and ganciclovir have had only limited success. Sorivudine, a new antiviral medication with activity against varicella-zoster virus, may represent an effective alternative treatment for retinal necrosis.
authors.affiliation: Visual Services Department, Massachusetts Eye and Ear Infirmary, Boston 02114, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Pinnolis
authors.forename: D
authors.initials: D
authors.lastname: Foxworthy
authors.forename: B
authors.initials: B
authors.lastname: Kemp
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001086:Arabinofuranosyluracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015774:Ganciclovir / Q000008:administration & dosage / Q000627:therapeutic use; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015882:Retinal Necrosis Syndrome, Acute / Q000188:drug therapy* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D001086:Arabinofuranosyluracil; C031368:sorivudine; D015774:Ganciclovir