[Anti-inflammatory effect of triptolide].
Triptolide (Tri) was isolated from Tripterygium wilfordii Hook f. Tri 0.1-0.2 mg.kg-1 sc or 0.15-0.3 mg.kg-1 ig inhibited markedly the increased vascular permeability induced by ip 0.7% HAc in mice. Tri 0.05-0.1 mg.kg-1 ip or 0.15-0.3 mg.kg-1 ig inhibited hind paws swelling induced by sc 0.15 ml carrageenan and also inhibited the same swelling induced by sc 2.5% formaldehyde 0.1 ml in rats. Tri 0.05-0.1 mg.kg-1 ip inhibited markedly proliferation of granuloma induced by sc implantation of cotton-pellets in rats, but 0.2 mg.kg-1 ip can not inhibit the same swelling induced by sc 0.15 ml carrageenan in adrenalectomized rats. Tri 0.2 mg.kg-1 ip decreased markedly weight of thymus. Tri 0.2 mg.kg-1 ip, but 0.1 mg.kg-1 ip did not reduced the content of ascorbic acid of adrenal gland in rats. Tri 0.2 mg.kg-1 ip did not decrease the pro-staglandin E content in inflammatory tissues. These results indicate that high dose of Tri can stimulate the pituitary-adrenal axis.
Zheng
Y L
YL
Department of Pharmacology, Fujian Institute of Medical Sciences, Fuzhou, China.
Lin
J F
JF
Lin
C C
CC
Xu
Y
Y
D000311:Adrenal Glands / Q000378:metabolism; D000315:Adrenalectomy; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D002199:Capillary Permeability; D002351:Carrageenan; D004224:Diterpenes / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004852:Epoxy Compounds; D015745:Granuloma, Foreign-Body / Q000188:drug therapy; D008297:Male; D051379:Mice; D010616:Phenanthrenes; D011458:Prostaglandins E / Q000378:metabolism; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; D011458:Prostaglandins E; C001899:triptolide; D002351:Carrageenan; D001205:Ascorbic Acid