title: Cortical blindness and seizures possibly related to cisplatin, vinblastine, and bleomycin treatment of ovarian dysgerminoma.
abstract: Ovarian dysgerminoma is the most common ovarian malignancy in young women. Conservative treatment is indicated in the reproductive-age woman who wishes to preserve childbearing capacity. This case report describes a patient with ovarian dysgerminoma who underwent chemotherapy with a cisplatin-vinblastine-bleomycin regimen that resulted in serious toxic complications--including cortical blindness and seizures--that were transient in nature. Although current chemotherapy regimens have dramatically improved the overall survival of women with germ-cell tumors, there are toxic complications such as those demonstrated in this report, and toxicity must be balanced against presumed benefit.
authors.affiliation: David Grand USAF Medical Center, Travis AFB, Calif.
authors.forename: D C
authors.initials: DC
authors.lastname: Young
authors.forename: A
authors.initials: A
authors.lastname: Mitchell
authors.forename: J
authors.initials: J
authors.lastname: Kessler
authors.forename: J E
authors.initials: JE
authors.lastname: Christman
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects; D001766:Blindness / Q000139:chemically induced*; D002945:Cisplatin / Q000009:adverse effects; D004407:Dysgerminoma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced*; D014747:Vinblastine / Q000009:adverse effects
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin