Hypermethylation at a chromosome 17 "hot spot" is a common event in ovarian cancer.
Alterations of normal DNA methylation patterns have been reported in various types of human tumors. These alterations are represented by genome wide hypomethylation and by region specific hypermethylation. One commonly hypermethylated region is 17p13.3 (D17S5), the putative site of a tumor suppressor gene. In this study we report that hypermethylation at this locus occurs frequently (33%) in ovarian tumors. We reported previously that loss of chromosome 17 is a common event in serous epithelial ovarian tumors. A correlation of the methylation event and chromosome 17 loss suggests that hypermethylation at D17S5 precedes chromosome 17 loss.
Pieretti
M
M
Department of Pathology, Markey Cancer Center, University of Kentucky Medical Center, Lexington 40536-0093, USA.
Powell
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DE
Gallion
H H
HH
Conway
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Case
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EA
Turker
M S
MS
D002116:Calcitonin / Q000378:metabolism; D002886:Chromosomes, Human, Pair 17 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008745:Methylation; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology
D002116:Calcitonin