[The effect of recombinant interleukin-1 beta on the chemotactic activity of neutrophilic leukocytes].
The role of interleukin-1 in the activation of neutrophils, the main effects of inflammatory reaction, is still unclear. This study has demonstrated that the recombinant preparation interleukin-1 beta (IL-1 beta) which the authors have obtained fails to produce a direct action on the locomotor functions of neutrophils. At the same time, injection of IL-1 beta in mice leads to neutrophilic migration to the injection site and their efflux into peripheral blood. These findings confirm the assumption that interleukin-1 produces a mediator effect on neutrophilic chemotaxis.
Konusova
V G
VG
Simbirtsev
A S
AS
Ketlinskiĭ
S A
SA
D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors
D007375:Interleukin-1; D011994:Recombinant Proteins; D009240:N-Formylmethionine Leucyl-Phenylalanine