[The host-opportunistic protozoon system. The manifestation of Leishmania infantum infection in naturally resistant adult white rats subjected to drug immunosuppression].
The attempt to overcome the natural resistance of white rats Wistar to Leishmania infantum infection was made by the mean of the immunodepressant Tricort-40, the corticosteroid of prolonged activity. In the series of experiments with the mercy scheme of immunosuppression the inoculation of the amastigotes L. infantum taken out of the donors, the golden hamsters Mesocricetus auratus, caused the progressive infection with intensive affection on target organs (the spleen, liver, bone marrow). The stem of L. infantum been passed through the immunosuppressed rats has preserved its pathogenicity to the golden hamsters.
Lavdovskaia
M V
MV
Kovalenko
F P
FP
Lysenko
A Ia
AIa
Chernov
Iu V
IuV
D000818:Animals; D006224:Cricetinae; D003692:Delayed-Action Preparations; D006790:Host-Parasite Interactions / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D018314:Leishmania infantum / Q000472:pathogenicity / Q000648:ultrastructure; D007898:Leishmaniasis, Visceral / Q000276:immunology / Q000469:parasitology*; D008647:Mesocricetus; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D003692:Delayed-Action Preparations; D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide