Motor dysfunction during sleep in posttraumatic stress disorder.
A subjective disturbance of sleep, including the occurrence of repetitive, stereotypical anxiety dreams, is characteristic of posttraumatic stress disorder (PTSD). The phenomenology of the PTSD anxiety dream has seemed most consistent with an underlying rapid eye movement (REM) sleep dysfunction. However, motor behavior reportedly can accompany PTSD dreams, and normal REM sleep typically involves a nearly total paralysis of the body musculature. As a means of understanding this discrepancy, anterior tibialis muscle activity during sleep was studied in a group of Vietnam combat veterans with current PTSD and in an age-matched normal control group. The PTSD subjects had a higher percentage of REM sleep epochs with at least one prolonged twitch burst; they also were more likely to have periodic limb movements in sleep, during nonrapid eye movement sleep. Both these forms of muscle activation also have been observed in REM behavior disorder (RBD), a parasomnia characterized by the actual enactment of dream sequences during REM sleep. The identification of RBD-like signs in PTSD adds to the evidence for a fundamental disturbance of REM sleep phasic mechanisms in PTSD.
Ross
R J
RJ
Research Service, Philadelphia Veterans Affairs Medical Center, Pennsylvania 19104.
Ball
W A
WA
Dinges
D F
DF
Kribbs
N B
NB
Morrison
A R
AR
Silver
S M
SM
Mulvaney
F D
FD
D004585:Electrooculography; D006801:Humans; D018482:Muscle, Skeletal / Q000503:physiopathology; D017286:Polysomnography; D011596:Psychomotor Disorders / Q000209:etiology* / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000209:etiology; D012895:Sleep, REM; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology / Q000523:psychology*