title: Experimental assessment of newly devised transcatheter stent-graft for aortic dissection.
abstract: Despite recent advances, surgical results for Stanford type B dissection are not yet satisfactory because the procedure is so highly invasive. The aim of this study was to devise a new intraaortic (IA) graft that would offer less invasive treatment for type B dissection. To close the entry of type B dissections using transcatheter placement, we devised an IA graft (inner diameter, 15-20 mm; length, 40 to 60 mm) in which a self-expandable stent was covered with a thin, open-cell-structured polyurethane jacket. In acute animal experiments in which type B aortic dissections were prepared in 4 mongrel dogs, IA grafts were implanted to close the entry using a transfemoral catheter sheath, and closure of all the entries was confirmed by aortography. In chronic experiments, five IA grafts for normal descending aortas and one IA graft for an experimentally dissected aorta were implanted to observe histologic biocompatibility for up to 8 months. Histopathologic examination conducted at the projected sacrifice periods revealed that endothelialization of the luminal surface of the IA graft had begun as early as 1 month after implantation and was completed within 4 months. The prototype device that we developed may be promising as an effective, minimally invasive therapeutic intervention for closure of the entry site of type B dissection.
authors.affiliation: Division of Cardiovascular Surgery, Osaka Prefectural Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Kuratani
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: K
authors.initials: K
authors.lastname: Ohnishi
mesh_terms: D000784:Aortic Dissection / Q000628:therapy*; D000818:Animals; D001011:Aorta / Q000502:physiology; D001014:Aortic Aneurysm / Q000628:therapy*; D001807:Blood Vessel Prosthesis / Q000295:instrumentation*; D004285:Dogs; D008855:Microscopy, Electron, Scanning; D011474:Prosthesis Design; D012038:Regeneration; D015607:Stents