title: Accelerated hypertension and nephroangiosclerosis associated with antiphospholipid syndrome. Report of two cases and review of the literature.
abstract: We describe two patients with the primary antiphospholipid syndrome who presented with severe hypertension. Renal biopsy specimen provided histologic evidence of intra-renal vascular disease with intravascular microthrombosis and nephrosclerosis, without feature of proliferative glomerulopathy. Accelerated hypertension and nephroangiosclerosis might indeed be one of the complications associated with anticardiolipin antibodies. The mechanism responsible might be the interaction of anticardiolipin antibodies, platelets and endothelial cell leading to microthrombi formation and increased local mitogenic activity that attract and stimulate neighbouring smooth muscle cell and fibroblast proliferation.
authors.affiliation: Department of Internal Medicine, CHU Sainte-Marguerite, Marseille, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Durand
authors.forename: P
authors.initials: P
authors.lastname: Lefevre
authors.forename: G
authors.initials: G
authors.lastname: Kaplanski
authors.forename: P
authors.initials: P
authors.lastname: Casanova
authors.forename: J
authors.initials: J
authors.lastname: Soubeyrand
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000378:metabolism; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D006978:Hypertension, Renovascular / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D009400:Nephrosclerosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006435:Renal Dialysis
chemical_list: D016682:Lupus Coagulation Inhibitor