title: Obesity associated insulin resistance occurs in hypopituitary subjects.
abstract: The study aimed to assess the role of pituitary hormones in the relationship between insulin resistance and obesity. Twelve male subjects with hypopituitarism secondary to surgery for a non-functioning pituitary adenoma were recruited. Subjects were receiving replacement hormones. Fasting plasma samples were taken for insulin, C-peptide, glucose, and lipids. Body mass index and blood pressure were measured. In hypopituitary subjects on replacement therapy, a positive association between body mass index and fasting plasma insulin levels (r = 0.76, p < 0.004) was similar to that found in normal subjects. In conclusion pituitary function does not have a direct role in determining the relationship between fasting plasma insulin, an index of insulin resistance, and obesity.
authors.affiliation: Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK.
authors.forename: R C
authors.initials: RC
authors.lastname: Page
authors.forename: J
authors.initials: J
authors.lastname: Levy
authors.forename: R C
authors.initials: RC
authors.lastname: Turner
mesh_terms: D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology / Q000503:physiopathology*; D007018:Hypopituitarism / Q000150:complications / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D010907:Pituitary Hormones / Q000502:physiology*; D012044:Regression Analysis
chemical_list: D010907:Pituitary Hormones