Vasopressin deficiency and blood glucose interactions on passive avoidance behavior.
The performance of a passive avoidance task (measured for two trials based upon number of complete step-downs and latency to respond) and blood glucose levels were examined in five groups of animals. The groups included vasopressin-deficient (DI) and vasopressin-containing (LE) rats under ad lib (AL) and food-restricted (FR) conditions, as well as DI-FR animals provided with access to an 8% sucrose solution (SUC). In the AL condition, no significant differences were found between DI and LE animals in either step-down occurrences or blood glucose levels. However, the DI animals were significantly slower in latency to respond in trial 1. With FR, the LE animals resembled the LE-AL animals in both passive avoidance behavior and blood glucose levels. The DI-FR animals that were not provided with SUC showed an impairment in passive avoidance behavior and low blood glucose levels, whereas DI-FR animals provided with SUC showed an amelioration of passive avoidance deficiencies and had blood glucose levels comparable to AL animals and LE-FR animals. On trial 2, a significant negative correlation was found between number of step-down occurrences and blood glucose levels, and a significant positive correlation was found between latency to respond and blood glucose levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Murphy
H M
HM
Department of Psychology, John Carroll University, Cleveland, OH 44118.
Babey
E M
EM
Wideman
C H
CH
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D004327:Drinking Behavior; D005247:Feeding Behavior; D005508:Food Deprivation; D008297:Male; D051381:Rats; D011930:Reaction Time; D012016:Reference Values; D013395:Sucrose; D014667:Vasopressins / Q000172:deficiency*
D001786:Blood Glucose; D014667:Vasopressins; D013395:Sucrose