title: Effect of dietary nucleotides on the fatty acid composition of rat liver microsomes.
abstract: The present study was designed to evaluate the influence of dietary nucleotides on the lipid composition of liver microsomes in weanling rats. Rats at weaning were fed, one group with a semipurified nucleotide-free diet and three groups with the same diet supplemented with three different levels of each of the nucleotides AMP, GMP, IMP, UMP and CMP, during 4 weeks. Long chain polyunsaturated fatty acids of the n-6 and n-3 series were increased in phospholipids of liver microsomes for rats fed the nucleotide supplemented diets; however, the cholesterol/phospholipid phosphorus ratio was maintained fairly constant. The results obtained suggest that dietary nucleotides modify the polyunsaturated fatty acid metabolism through a lower rat liver delta-9 desaturase activity and through increased activities of delta-5 and delta-4 desaturases.
authors.affiliation: Department of Research of Uniasa, University of Granada, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Núñez
authors.forename: M V
authors.initials: MV
authors.lastname: Ayudarte
authors.forename: A
authors.initials: A
authors.lastname: Gil
authors.forename: M D
authors.initials: MD
authors.lastname: Suárez
mesh_terms: D000818:Animals; D004032:Diet; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009711:Nucleotides / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014886:Weaning
chemical_list: D005227:Fatty Acids; D009711:Nucleotides; D044943:Fatty Acid Desaturases