Direct identification of lung cancer cells producing granulocyte colony stimulating factor with monoclonal anti-G-CSF antibodies.
This is a case report of an 82-year-old man with squamous cell lung cancer which produced G-CSF. The leukocyte cell count was elevated to 94,400/mm3. The serum G-CSF concentration was also elevated to 351 pg/ml. This is the first report to demonstrate, by application of immunohistochemical staining techniques directly to tumor tissue obtained at autopsy, squamous carcinoma cells which produce G-CSF. The tumor cells were stained with monoclonal anti-G-CSF antibodies.
Nagatomo
A
A
Department of Internal Medicine, Kawasaki Municipal Hospital, Japan.
Ooike
H
H
Harada
A
A
Sasaki
T
T
Hanada
T
T
Matuoka
Y
Y
Irimajiri
S
S
Kishimoto
H
H
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001249:Asthma / Q000175:diagnosis; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D003951:Diagnostic Errors; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D051379:Mice; D009363:Neoplasm Proteins / Q000032:analysis / Q000378:metabolism*; D011859:Radiography
D000911:Antibodies, Monoclonal; D009363:Neoplasm Proteins; D016179:Granulocyte Colony-Stimulating Factor