Physical methods for the detection of carcinogen-DNA adducts in humans.
This report has attempted to summarize the principles, advantages, limitations and the source of data derived in the use of physical detection techniques for DNA-adduct measurement in human biomonitoring. Each method, although inherently chemically-specific, has advantages and limitations depending on the adduct type under study. These methods have a niche that is at least consistent with corroborative technology, and are being applied to dosimetry problems in the field.
Weston
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Molecular Epidemiology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
D002273:Carcinogens / Q000032:analysis* / Q000378:metabolism; D002849:Chromatography, Gas / Q000379:methods; D003217:Conductometry; D004247:DNA / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D004249:DNA Damage; D004252:DNA Mutational Analysis / Q000379:methods*; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D013050:Spectrometry, Fluorescence / Q000379:methods; D013054:Spectrophotometry, Atomic
D002273:Carcinogens; D004247:DNA