title: Immunoreactive substance P in human saliva. A possible marker of chronic pain.
abstract: In all patients and volunteers, the levels of immunoreactive SP measured in saliva were about 100 times higher than the levels measured in plasma. SP per mg protein was consistently lower in both plasma and saliva of chronic pain patients than in healthy volunteers. These findings suggest that a simple noninvasive objective method of determining SP in saliva may become useful in the evaluation and treatment of chronic pain.
authors.affiliation: Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2125.
authors.forename: W C
authors.initials: WC
authors.lastname: Parris
authors.forename: B V
authors.initials: BV
authors.lastname: Sastry
authors.forename: J R
authors.initials: JR
authors.lastname: Kambam
authors.forename: R J
authors.initials: RJ
authors.lastname: Naukam
authors.forename: B W
authors.initials: BW
authors.lastname: Johnson
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D002908:Chronic Disease; D006801:Humans; D017116:Low Back Pain / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D013373:Substance P / Q000032:analysis* / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D012471:Salivary Proteins and Peptides; D013373:Substance P