Familial leukemia: description of two kindreds and a review of the genetic aspects of the disease.
We describe two kindreds of Arab ancestry characterized by multiple cases of acute lymphoblastic leukemia. Consanguinity and intermarriages were prevalent in the two families. Age, mode of presentation, characteristics of the leukemic cells, response to treatment and prognosis were remarkably similar among the patients. A short review of the literature on familial leukemia is given.
Kende
G
G
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Toren
A
A
Mandel
M
M
Neumann
Y
Y
Kenet
G
G
Brok-Simoni
F
F
Ramot
B
B
Ben-Bassat
I
I
Rechavi
G
G
D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014427:Twins