Binding of non-homologous series of anticancer drugs to glutathione.
The interaction of 17 anticancer drugs with reduced glutathione was studied by charge-transfer reversed-phase thin-layer chromatography and the hydrophobicity, the specific hydrophobic surface area and the relative strength of interaction was calculated. Only 7 anticancer drugs showed significant interaction with glutathione, the relative strength of interaction depended significantly neither on the hydrophobicity nor on the specific hydrophobic surface area of the drugs. As the interacting drugs are basic compounds it is reasonable to suppose that their interaction with the acidic glutathione is based on Coulombic forces. The direct binding of these drugs to glutathione makes it probable that glutathione may influence the biological activity of the bound anticancer drugs.
Cserháti
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Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D002855:Chromatography, Thin Layer; D004347:Drug Interactions; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism*
D000970:Antineoplastic Agents; D005978:Glutathione