title: Clinical case report: opiate antagonist and event-related desynchronization in 2 autistic boys.
abstract: Event-related desynchronization and visual orientational behavior were examined in 2 autistic boys to determine if blockade of endogenous opioid activity facilitates cognitive processing at a cortical level. Before naltrexone, the boys showed no selective alpha blocking during exposure to either mother's pictures or white light. Unlike normals, they exhibited strong alpha band enhancement at temporocentral recording sites. Two hours after administering 0.5 mg/kg naltrexone, mother-as well as light-related alpha blocking appeared at occipital, occipitotemporal, and prefrontal sites. These effects were gone 24 h after dosing in one child, but persisted in the other. A parallel increase in visual pursuit in a social context was observed. These results affirm that autistic gaze aversion can be caused by excessive opioid activity interfering with corticothalamocortical processing of visual stimuli.
authors.affiliation: Department of Physiological Psychology, University of Salzburg, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Lensing
authors.forename: H
authors.initials: H
authors.lastname: Schimke
authors.forename: W
authors.initials: W
authors.lastname: Klimesch
authors.forename: V
authors.initials: V
authors.lastname: Pap
authors.forename: G
authors.initials: G
authors.lastname: Szemes
authors.forename: D
authors.initials: D
authors.lastname: Klingler
authors.forename: J
authors.initials: J
authors.lastname: Panksepp
mesh_terms: D000513:Alpha Rhythm / Q000187:drug effects; D001321:Autistic Disorder / Q000175:diagnosis / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D002648:Child; D003344:Cortical Synchronization; D006801:Humans; D008027:Light; D008297:Male; D009271:Naltrexone / Q000494:pharmacology*; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D018847:Opioid Peptides / Q000037:antagonists & inhibitors / Q000502:physiology*; D011698:Pursuit, Smooth / Q000187:drug effects; D013788:Thalamus / Q000187:drug effects / Q000502:physiology; D014796:Visual Perception
chemical_list: D018847:Opioid Peptides; D009271:Naltrexone