Atrial natriuretic factor antagonises angiotensin II--induced vasopressin release in rat subfornical organ.
The coexistence of Atrial Natriuretic Factor (ANF) and Angiotensin II (Ang II) receptors in the subfornical organ suggested that ANF may influence the action of Ang II at this level. To test this hypothesis the effect of ANF pre injected into subfornical organ (SFO) on Ang II-induced vasopressin release was investigated in rats. ANF blunted vasopressin release elicited by circulating Ang II. This study indicates SFO as one of the main sites at which ANF-Ang II interactions occur.
Steardo
L
L
Institute of Pharmacology, Medical School, University of Bari.
Steardo
M D
MD
Testa
N
N
Attanasio
A
A
Persichella
M
M
Cuomo
V
V
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018000:Receptors, Peptide / Q000187:drug effects; D013356:Subfornical Organ / Q000187:drug effects*; D014667:Vasopressins / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D018000:Receptors, Peptide; C472610:atrial natriuretic peptide, rat; D014667:Vasopressins; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor