title: Serum sialic acid and acute-phase proteins in hypertriglyceridaemic patients showing the Frederickson's type IIB phenotype.
abstract: 1. We have shown that serum total sialic acid is elevated in hypertriglyceridaemic patients showing the Frederickson's type IIB phenotype in comparison with normal subjects (2.30 +/- 0.34 versus 1.92 +/- 0.32 mmol/l, P < 0.02). Lipid-associated sialic acid was also elevated in the hypertriglyceridaemic group in comparison with the normal subjects (0.60 +/- 0.09 versus 0.35 +/- 0.04 mmol/l, P < 0.001). 2. We measured five serum acute-phase proteins in the hypertriglyceridaemic patients and the normal subjects, namely alpha 1-antichymotrypsin, alpha 1-acid glycoprotein, alpha 2-macroglobulin, C-reactive protein and haptoglobin. Serum alpha 2-macroglobulin was significantly elevated in the hypertriglyceridaemic patients compared with the normal subjects (2.1 +/- 1.0 versus 1.5 +/- 0.55 g/l, P < 0.05) as was serum C-reactive protein (5.9 +/- 3.5 versus 3.5 +/- 1.9 mg/l, P < 0.05). There were, however, no significant differences in the serum concentrations of alpha 1-antichymotrypsin, alpha 1-acid glycoprotein or haptoglobin between the two groups. 3. There was a significant correlation between serum total sialic acid and serum alpha 1-antichymotrypsin, alpha 1-acid glycoprotein and haptoglobin (Spearman correlation coefficients 0.74, 0.50 and 0.76, respectively) in the normal subjects, and there was a significant correlation between serum total sialic acid and serum alpha 1-antichymotrypsin and alpha 1-acid glycoprotein (Spearman correlation coefficients 0.72 and 0.84, respectively) in the hypertriglyceridaemic patients.
authors.affiliation: Department of Clinical Chemistry, Guy's Hospital, London, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Haq
authors.forename: P
authors.initials: P
authors.lastname: Tutt
authors.forename: M
authors.initials: M
authors.lastname: Haq
authors.forename: M
authors.initials: M
authors.lastname: Crook
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D015228:Hypertriglyceridemia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D009961:Orosomucoid / Q000032:analysis; D010641:Phenotype; D010865:Pilot Projects; D012794:Sialic Acids / Q000097:blood*; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D012794:Sialic Acids; D000514:alpha 1-Antichymotrypsin; D000511:alpha-Macroglobulins; D002097:C-Reactive Protein; D019158:N-Acetylneuraminic Acid