[The effect of phenol derivatives on the antimutagenic activity of dextran].
The effects of dextran + hydrazine or amino derivative of dibunol and of dextran + cystafos derivatives with different degree of modification of their molecules on the mutagenic activity of gamma irradiation were studied using the micronucleus test in polychromatophilic erythrocytes of the mouse bone marrow. The effects of these compounds on differentiation of the erythroid series has also been studied. The mutagenic activity of gamma irradiation was most markedly inhibited by the copolymer dextran and the amino derivative dibunol. The optimal structure of copolymers was 1 heterocyclic link per 3 non-oxidized links of dextran, while the increasing number of active links in the dextran molecule insignificantly enhanced its antimutagenic effect. The studied compounds effectively protected erythropoiesis.
Bakhitova
L M
LM
Drobchenko
S N
SN
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D003539:Cystaphos / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology*; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D004920:Erythropoiesis / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects / Q000528:radiation effects; D010636:Phenols / Q000494:pharmacology*
D016587:Antimutagenic Agents; D003911:Dextrans; D010636:Phenols; D002084:Butylated Hydroxytoluene; D003539:Cystaphos