title: t(11;18)(q21;q21) may delineate a spectrum of diffuse small B-cell lymphoma with extranodal involvement.
abstract: We describe a patient with stage IV non-Hodgkin's lymphoma (NHL) and a t(11;18)(q21;q21) translocation. He presented with a gastric small B-cell lymphocytic lymphoma, expressing IgAL immunoglobulins without expression of CD10, CD5, and CD23 antigens. The lymphoma was the final development of a 6-year history of a monoclonal IgAL increase complicated by severe renal failure due to membranoproliferative glomerulonephritis. The clinical, histological, immunologic, and cytogenetic features of this patient are very similar to those observed in the five other patients with t(11;18) reported to date. This translocation therefore seems to delineate a new subtype of diffuse small B-cell lymphoma with involvement of mucosal sites. Involvement of the BCL2 oncogene on 18q21 could not be detected using molecular techniques with 5' as well as 3' BCL2 probes, indicating that other, so far unknown, genes relevant to lymphoid differentiation could be located in 18q21 and 11q21.
authors.affiliation: Department of Genetics, University Hospital of Grenoble, France.
authors.forename: D
authors.initials: D
authors.lastname: Leroux
authors.forename: P
authors.initials: P
authors.lastname: Seité
authors.forename: J
authors.initials: J
authors.lastname: Hillion
authors.forename: F
authors.initials: F
authors.lastname: Le Marc'hadour
authors.forename: B
authors.initials: B
authors.lastname: Pégourié-Bandelier
authors.forename: M C
authors.initials: MC
authors.lastname: Jacob
authors.forename: C J
authors.initials: CJ
authors.lastname: Larsen
authors.forename: J J
authors.initials: JJ
authors.lastname: Sotto
mesh_terms: D015703:Antigens, CD / Q000097:blood; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002887:Chromosomes, Human, Pair 18; D005819:Genetic Markers; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015183:Restriction Mapping; D014178:Translocation, Genetic
chemical_list: D015703:Antigens, CD; D005819:Genetic Markers; D007070:Immunoglobulin A