Primary structure and functional expression of a cyclic nucleotide-gated channel from rabbit aorta.
Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sino-atrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.
Biel
M
M
Institut für Pharmakologie und Toxikologie, Technischen Universität München, Germany.
Altenhofen
W
W
Hullin
R
R
Ludwig
J
J
Freichel
M
M
Flockerzi
V
V
Dascal
N
N
Kaupp
U B
UB
Hofmann
F
F
D000595:Amino Acid Sequence; D000818:Animals; D001011:Aorta / Q000737:chemistry*; D001483:Base Sequence; D002417:Cattle; D003062:Codon; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004594:Electrophysiology; D015870:Gene Expression; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects*; D007473:Ion Channels / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D011817:Rabbits; D017386:Sequence Homology, Amino Acid
D003062:Codon; D007473:Ion Channels; D004247:DNA; D000242:Cyclic AMP; D006152:Cyclic GMP