Pathologist variation in reporting cervical borderline epithelial abnormalities and cervical intraepithelial neoplasia.
OBJECTIVE
To evaluate the interobserver variation in the diagnosis of cervical intraepithelial lesions, including the new category "borderline abnormalities of uncertain significance" (BAUS) which has not been tested before.


METHODS
Biopsy specimens of 122 patients were reviewed by five histopathologists and the diagnoses subjected to kappa statistical analysis.


RESULTS
There was poor interobserver agreement in all categories, particularly between BAUS and normal tissue.


CONCLUSIONS
The current guidelines for the histological diagnosis of cervical intraepithelial neoplasia and BAUS are poorly reproducible.
Creagh
T
T
Department of Histopathology and Cytopathology, St Mary's Hospital, London.
Bridger
J E
JE
Kupek
E
E
Fish
D E
DE
Martin-Bates
E
E
Wilkins
M J
MJ
D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D015588:Observer Variation; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology; D014412:Tumor Virus Infections / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000145:classification / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000145:classification / Q000473:pathology*