Relationship of interleukin-1 beta and beta 2-microglobulin with neuropeptides in cerebrospinal fluid of patients with dementia of the Alzheimer type.
We studied interleukin-1 beta (IL-1 beta), beta 2-microglobulin (beta 2-m), beta-endorphin, substance P, neuropeptide Y and somatostatin concentrations in the cerebrospinal fluid of 13 patients with dementia of the Alzheimer type (DAT), 13 patients with multi-infarct dementia (MID) and 15 age-matched control subjects. Substance P was significantly lower in DAT than in controls (P < 0.05), as well as somatostatin in DAT as compared to both controls (P < 0.01) and MID (P < 0.05), whereas beta 2-m was higher in DAT than in controls (P < 0.01). Neuropeptide Y, beta-endorphin and IL-1 beta showed similar concentrations in the three groups studied. A significantly positive correlation was observed between IL-1 beta and substance P (r = 0.79, P < 0.01) and somatostatin (r = 0.75, P < 0.05) in DAT, which was not observed in MID. In addition, beta 2-m showed a negative correlation with IL-1 beta (r = -0.73, P < 0.05) in DAT, and age correlated negatively with IL-1 beta in controls and MID, but positively in DAT. Therefore, these results support the idea that an altered relationship may exist in Alzheimer's disease between the nervous and immune system.
Martinez
M
M
Servicio de Bioquímica Hospital La Paz del Insalud, Madrid, Spain.
Frank
A
A
Hernanz
A
A
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000134:cerebrospinal fluid*; D008297:Male; D009478:Neuropeptide Y / Q000134:cerebrospinal fluid; D013004:Somatostatin / Q000134:cerebrospinal fluid; D013373:Substance P / Q000134:cerebrospinal fluid; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*; D001615:beta-Endorphin / Q000134:cerebrospinal fluid
D007375:Interleukin-1; D009478:Neuropeptide Y; D001613:beta 2-Microglobulin; D013373:Substance P; D013004:Somatostatin; D001615:beta-Endorphin