title: Angiotensin-(1-7) and nitric oxide synthase in the hypothalamo-neurohypophysial system.
abstract: The organization of angiotensin (Ang)-(1-7) immunoreactivity with respect to neurons containing the nitric oxide synthase, nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), in the hypothalamo-neurohypophysial (HNS) system was examined. The majority of neurons in this system were single labeled with Ang-(1-7) or NADPH-d and were found localized in two separate populations of neurons within the HNS. A small number of double-labeled neurons were observed in the supraoptic (SO) and paraventricular (PV) nuclei. Double-labeled accessory neurosecretory neurons were also found distributed between the SO and PV. Although a well-defined function for nitric oxide in the magnocellular hypothalamic system has not been determined, the codistribution and limited coexistence of Ang-(1-7), a heptapeptide involved in antidiuresis, and NADPH-d in the HNS suggests a potential role for these substances in mechanisms modulating fluid homeostasis.
authors.affiliation: Research Institute, Cleveland Clinic Foundation, OH 44195.
authors.forename: J
authors.initials: J
authors.lastname: Calka
authors.forename: C H
authors.initials: CH
authors.lastname: Block
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000803:Angiotensin I; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology*; D007150:Immunohistochemistry; D008297:Male; D009249:NADP / Q000502:physiology; D019001:Nitric Oxide Synthase; D010286:Paraventricular Hypothalamic Nucleus / Q000033:anatomy & histology / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013495:Supraoptic Nucleus / Q000033:anatomy & histology / Q000502:physiology
chemical_list: D010446:Peptide Fragments; D000804:Angiotensin II; D009249:NADP; D000803:Angiotensin I; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; C118790:angiotensin I (1-7)