Effects of ganglioside administration on experimental autoimmune neuritis induced by peripheral nerve myelin or P2-specific T cell lines.
We studied the effects of ganglioside administration in two animal models of inflammatory demyelinating polyneuropathy. We administered a mixture of bovine brain gangliosides intraperitoneally to Lewis rats with myelin-induced or T cell line-mediated experimental autoimmune neuritis (EAN). Under the experimental conditions we had chosen, we only detected marginal but not statistically significant effects on disease course and severity, as evidenced by motor function, electrophysiological findings, and morphological signs of inflammation and demyelination. There was no significant induction of antibody production against gangliosides, and we did not detect signs of increased cellular reactivity towards gangliosides. We conclude that the administration of gangliosides modulates EAN at best marginally, and does not induce a cellular or humoral immune reaction.
Zielasek
J
J
Department of Neurology, University of Würzburg, Germany.
Jung
S
S
Schmidt
B
B
Ritter
G
G
Hartung
H P
HP
Toyka
K
K
D000818:Animals; D000917:Antibody Formation; D002417:Cattle; D002460:Cell Line; D005260:Female; D005732:Gangliosides / Q000276:immunology / Q000494:pharmacology*; D006001:Glycoconjugates / Q000276:immunology; D016219:Immunotherapy, Adoptive; D008213:Lymphocyte Activation / Q000187:drug effects; D004676:Myelin Basic Protein / Q000276:immunology*; D018996:Myelin P2 Protein; D009186:Myelin Sheath / Q000276:immunology*; D009444:Neuritis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology*; D010525:Peripheral Nerves / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*
D005732:Gangliosides; D006001:Glycoconjugates; D004676:Myelin Basic Protein; D018996:Myelin P2 Protein