Chromosomal abnormalities in choriocarcinomas of the female.
We have studied six cases of choriocarcinomas in the female by conventional cytogenetic analysis and by in situ hybridization using a 12p painting probe, and found evidence for chromosome 12 abnormalities in two of them. Abnormalities of chromosome 12 are a common occurrence in genitourinary tumors of the female, but their significance is not known. We discuss the present findings in relation to those in malignant ovarian germ cell tumors (MOGCTs).
Rodriguez
E
E
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Melamed
J
J
Reuter
V
V
Chaganti
R S
RS
D002822:Choriocarcinoma / Q000235:genetics*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D011247:Pregnancy; D014314:Trisomy; D014594:Uterine Neoplasms / Q000235:genetics*