Biochemical formulations of embryonic gene control.
A search for control mechanisms involving embryonic genes is explored reviewing a variety of subject areas including, a) the methylation status of DNA and the globin gene, b) ethionine and steroid effects on expression of embryonic genes, c) alpha-fetoprotein gene activity induced by carcinogens and in hepatomas. Also taken into account are transcriptional and cytogenetic aspects. Theories of heterochromatin dynamics are developed in connection with certain contributions from chromatin experimental findings, especially regarding the status of methylation. The potential importance to control theory of the inverse correlation between ATP:L-methionine S-adenosyltransferase activity and alpha-fetoprotein synthesis is emphasized. Several generalizations were derived during the study. It appears that the depression mechanisms may act only on genes that have been active in embryonic stages and have become repressed during differentiation. Another idea concerned heterochromatin. Any heterochromatic segment of DNA may represent at its associated ends a certain amount of euchromatin that would be in a quasi-heterochromatic state. Such pseudoheterochromatin is hypothesized to be induced by the true heterochromatin (eigenheterochromatin).
Hancock
R L
RL
Canadian Institute of Theoretical Biology, Nova Scotia.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D004622:Embryo, Mammalian / Q000378:metabolism*; D004625:Embryo, Nonmammalian; D005786:Gene Expression Regulation / Q000187:drug effects; D005914:Globins / Q000235:genetics; D008745:Methylation; D008954:Models, Biological; D013256:Steroids / Q000494:pharmacology; D000509:alpha-Fetoproteins / Q000235:genetics
D002273:Carcinogens; D002843:Chromatin; D013256:Steroids; D000509:alpha-Fetoproteins; D005914:Globins; D004247:DNA