Heterogeneity of brain gene expression in Alzheimer's disease.
We have examined the expression of several genes whose transcripts have increased levels in Alzheimer's disease and have found heterogeneity in these levels in different patients with this condition. The level of expression of these genes was compared to different clinical and pathological aspects of the disease. A case with markedly elevated alpha 1-antichymotrypsin mRNA levels demonstrated prominent neuronal accumulation of this protein. Many of the neurons which demonstrated alpha 1-antichymotrypsin staining did not have neurofibrillary tangles, and vice versa. This suggests that alpha 1-antichymotrypsin staining might identify a different facet of the pathology of Alzheimer's disease than does neurofibrillary tangle staining and may provide new information in the study of this condition.
Duguid
J R
JR
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
Trzepacz
C
C
Kemper
T
T
Tourtellote
W W
WW
Volicer
L
L
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D015415:Biomarkers; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012337:RNA, Ribosomal, 18S / Q000096:biosynthesis; D012016:Reference Values
D015415:Biomarkers; D012337:RNA, Ribosomal, 18S; D012313:RNA