Effect of chronic ethanol administration on the absorptive functions of the rat small intestine.
Ethanol feeding to rats for 40 days significantly (p < 0.01) depressed sodium-stimulated glucose and glycine uptakes at pH 5.5 and 7.2 without affecting sodium-independent solute transport in the rat intestine. Leucine uptake was essentially unaltered under these conditions. Absorption of bovine serum albumin and gamma-globulin as detected by enzyme-linked immunosorbent blocking assay (ELISA) was markedly augmented (p < 0.001) in ethanol-fed rats compared to the controls. These observations suggest that chronic ethanol intake differentially affects the uptake of organic solutes and macromolecules in the rat intestine.
Kaur
J
J
Department of Biochemistry, Panjab University, Chandigarh, India.
Jaswal
V M
VM
Nagpaul
J P
JP
Mahmood
A
A
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology; D014886:Weaning; D005719:gamma-Globulins / Q000378:metabolism
D005719:gamma-Globulins; D012710:Serum Albumin, Bovine; D000431:Ethanol; D012964:Sodium; D007930:Leucine; D005947:Glucose; D005998:Glycine