title: Heteromorphism of human chromosome 18 detected by fluorescent in situ hybridization.
abstract: The individual variations of pericentromeric heterochromatin in human chromosome 18 were analysed using the C-banding techniques and nonradioactive fluorescence in situ hybridization (FISH) with chromosome 18 alpha-satellite DNA probe. FISH analysis shows heteromorphisms almost undetectable by C-banding and which regularly segregate in a family.
authors.affiliation: Institute of Medical Genetics USL 31, Ferrara, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bonfatti
authors.forename: C
authors.initials: C
authors.lastname: Giunta
authors.forename: A
authors.initials: A
authors.lastname: Sensi
authors.forename: R
authors.initials: R
authors.lastname: Gruppioni
authors.forename: M
authors.initials: M
authors.lastname: Rubini
authors.forename: F
authors.initials: F
authors.lastname: Fontana
mesh_terms: D002871:Chromosome Banding; D002887:Chromosomes, Human, Pair 18 / Q000648:ultrastructure*; D015342:DNA Probes; D004276:DNA, Satellite / Q000648:ultrastructure; D005260:Female; D006570:Heterochromatin / Q000648:ultrastructure*; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008677:Metaphase; D013050:Spectrometry, Fluorescence
chemical_list: D015342:DNA Probes; D004276:DNA, Satellite; D006570:Heterochromatin