title: Glucose intolerance exaggerates left ventricular hypertrophy and dysfunction in essential hypertension.
abstract: The influence of glucose intolerance, the preclinical stage of diabetes mellitus, on the progression of left ventricular hypertrophy and left ventricular dysfunction in essential hypertension, was assessed with two-dimensional M-mode echocardiography in age- and sex-matched essential hypertensive patients with (n = 28) or without (n = 44) glucose intolerance, and normotensive control subjects (n = 29). Left ventricular mass index in hypertensive patients with glucose intolerance was significantly higher than that in hypertensive patients without glucose intolerance (mean +/- SD, 115.6 +/- 28.2 v 102.1 +/- 22.1 g/m2; P < .05). Left ventricular diastolic function as reflected by peak lengthening rate was reduced in glucose-intolerant hypertensive patients than in hypertensive patients without glucose intolerance (2.68 +/- 0.71 v 3.16 +/- 0.82/sec; P < .05). End-systolic wall stress/left ventricular end-systolic volume index, an index of left ventricular contractility, was reduced more in glucose-intolerant hypertensive patients than in hypertensive patients without glucose intolerance (2.75 +/- 0.55 v 3.13 +/- 0.55 10(3) dyn.m2/cm2.mL-1; P < .01). These findings suggest that glucose intolerance accelerates progression of left ventricular hypertrophy and deteriorates left ventricular diastolic function and contractility in essential hypertension.
authors.affiliation: Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hara-Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Kohara
authors.forename: T
authors.initials: T
authors.lastname: Sumimoto
authors.forename: M
authors.initials: M
authors.lastname: Lin
authors.forename: K
authors.initials: K
authors.lastname: Hiwada
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D004452:Echocardiography; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000473:pathology*; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000473:pathology*; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000473:pathology*
chemical_list: D001786:Blood Glucose; D007328:Insulin