title: Effect of head-down tilt on cardiovascular control in healthy subjects: a spectral analytic approach.
abstract: 1. The purpose of this investigation was to determine non-invasively the changes in autonomic cardiovascular control observed in normal subjects submitted to acute cardiopulmonary blood volume expansion by 100 degrees head-down tilt. The effect of head-down tilt on finger blood pressure and heart rate fluctuations was studied by means of power spectral analysis in 12 healthy men. 2. Amplitude spectra of heart rate and blood pressure rhythmicity were estimated at the low-frequency (60-140 mHz, 10-s rhythm) and high-frequency (area under the curve at mean respiration rate +/- 50 mHz) component. Transfer gain and phase were calculated between systolic blood pressure and heart rate. Forearm vascular resistance was estimated to validate the head-down procedure. 3. Forearm vascular resistance decreased significantly from 19.82 (16.34-26.46) mmHg ml-1 min 100 ml to 18.05 (13.69-22.88) mmHg ml-1 min 100 ml (P < 0.01) during head-down tilt (values are medians and 25 and 75 percentiles). The overall variability (total area under the curve of the spectrum from 20 to 500 mHz) of blood pressure and heart rate time series was consistently reduced with head-down tilt. 4. The spectral pattern of systolic blood pressure showed a diminution of the absolute and relative low-frequency component during head-down tilt: absolute log-transformed values, 2.86 (2.80-2.94) mmHg/Hz1/2 versus 2.77 (2.72-2.82) mmHg/Hz1/2 (P < 0.05); relative values, 35% (32-37%) versus 32% (29-32%) (P < 0.05). In heart rate spectra only the absolute low-frequency component decreased.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pharmacology, Faculty of Medicine Necker, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Weise
authors.forename: G M
authors.initials: GM
authors.lastname: London
authors.forename: A P
authors.initials: AP
authors.lastname: Guerin
authors.forename: B M
authors.initials: BM
authors.lastname: Pannier
authors.forename: J L
authors.initials: JL
authors.lastname: Elghozi
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005542:Forearm / Q000098:blood supply; D018475:Head-Down Tilt / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011311:Pressoreceptors / Q000502:physiology*; D012039:Regional Blood Flow; D012815:Signal Processing, Computer-Assisted; D016683:Supine Position / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology