title: C-type natriuretic peptide inhibits intimal thickening after vascular injury.
abstract: Recently we have found that C-type natriuretic peptide (CNP) inhibits proliferation of cultured rat vascular smooth muscle cells through an elevation of cGMP. We have now tested whether administration of CNP inhibits the development of intimal lesions induced by air-drying injury in rat common carotid arteries in vivo. CNP treatment (1 microgram/kg per min, iv infusion) for either 14 or 5 days resulted in 70% or 60% reduction, respectively, of intimal cross-section area 14 days after injury as compared with control rats. We also found that CNP potently stimulated cGMP production in injured carotid arteries with intimal thickening, but not in intact ones. These results indicate that GC-B, CNP specific receptor/guanylyl cyclase, is expressed at the sites of vascular injury, and that CNP might be efficacious in the prevention of restenosis caused by intimal thickening following coronary angioplasty.
authors.affiliation: Department of Experimental Pharmacology, Suntory Institute for Biomedical Research, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Furuya
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: N
authors.initials: N
authors.lastname: Honbou
authors.forename: K
authors.initials: K
authors.lastname: Kawashima
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Kangawa
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002339:Carotid Arteries; D006152:Cyclic GMP / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000293:injuries*; D006162:Guanylate Cyclase / Q000378:metabolism; D008297:Male; D020098:Natriuretic Peptide, C-Type; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins
chemical_list: D011506:Proteins; D011994:Recombinant Proteins; D020098:Natriuretic Peptide, C-Type; D006162:Guanylate Cyclase; D006152:Cyclic GMP