title: A new thymopoietin precursor gene from human thymus.
abstract: Thymopoietin-related peptide (TPRP) gene was identified and cloned from a human thymus cDNA library. The cloned cDNA encoded a mature TPRP including the active site of thymopoietin (TP) (residues 32-36). TPRP and bovine TP were very similar in amino acid sequence, each being a 49 amino acid linear polypeptide. TPRP differed in only one residue from bovine putative TP and in only five residues from bovine TP I; whereas TPRP differed much more, at 12 amino acid residues, from human TP from thymus. This suggests that TPRP is a novel peptide and a genuine counterpart of the bovine TP.
authors.affiliation: Clinical Research Center, Utano National Hospital, Kyoto, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: N
authors.initials: N
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Ohta
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D009157:Myasthenia Gravis / Q000378:metabolism; D011498:Protein Precursors / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013946:Thymopoietins / Q000235:genetics*; D013950:Thymus Gland / Q000378:metabolism*
chemical_list: D018076:DNA, Complementary; D011498:Protein Precursors; D013946:Thymopoietins; C092927:thymopoietin-related peptide precursor