title: Fasting/refeeding has little lasting effect on long-chain fatty acids accumulating in the developing rat conceptus.
abstract: The objective of this study was to delineate the influence of maternal fasting-refeeding on accumulation of long-chain fatty acids by the developing conceptus in chow-fed pregnant rats. At term, the rat conceptus normally accumulates < 5% of total maternal whole body n - 6 polyunsaturates and < 15% of whole body n - 3 polyunsaturates. In contrast to the ad libitum-fed controls, the conceptus of fasted-refed rats was the main site of accumulation of n - 6 and n - 3 polyunsaturates since the maternal carcass (excluding liver) actually had a lower content of polyunsaturates at the end of the fasting-refeeding period than at the start. The rise in the content of triacylglycerols in the conceptus during fasting was specifically attributable to increased arachidonate, docosatetraenoate and docosahexaenoate; all changes in conceptus triacylglycerols were back to ad libitum control values by the end of the refeeding period (term). Conversely, although conceptus total phospholipids did not change significantly during fasting-refeeding, there was a net increase in the phospholipid content of both palmitate and oleate in conceptus after refeeding. We conclude that the developing rat conceptus is largely resistant to the marked changes in maternal fatty acid intake and retention that occur during fasting and refeeding.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada.
authors.forename: S C
authors.initials: SC
authors.lastname: Cunnane
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Chen
mesh_terms: D000818:Animals; D005215:Fasting; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D010743:Phospholipids / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats / Q000196:embryology*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D010743:Phospholipids; D014280:Triglycerides