title: Changes in the activity of antioxidant enzymes (SOD, GPX, CAT) after experimental spinal cord injury.
abstract: We determined time dependent changes in the levels of the antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) at 1, 4 and 24 hours after standardized reversible spinal cord injury in rats. In each segment (rostral, lesion, caudal) enzyme activities at 1, 4 and 24 hours were not significantly different. Without time limitation we have found that SOD and GPx activities were not significantly different (p > 0.05), but CAT activity was significantly high (p = 0.008) in the lesion segment than the rostral and caudal segment. According to our results we suggest that one of the main reason for tissue damage during such a spinal cord trauma model may be neither H2O2 nor H2O2 derived radicals.
authors.affiliation: Istanbul University Cerrahpaşa Medical Faculty Department of Neurosurgery, Aksaray, Turkey.
authors.forename: M Y
authors.initials: MY
authors.lastname: Kaynar
authors.forename: M
authors.initials: M
authors.lastname: Hanci
authors.forename: C
authors.initials: C
authors.lastname: Kuday
authors.forename: A
authors.initials: A
authors.lastname: Belce
authors.forename: K
authors.initials: K
authors.lastname: Gumustas
authors.forename: E
authors.initials: E
authors.lastname: Kokoglu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase