Triiodothyronine increases desipramine with changing the concentrations of monoamines, in the brain of rat given imipramine.
After treatment with triiodothyronine (T3) for 5 days, rats received a single i.p. injection of imipramine. The concentrations of imipramine and desipramine decreased and increased, respectively, in the brains of T3-treated rats, and the elimination half-time of desipramine was increased. In rats that had received imipramine for 7 days, cotreatment with T3 also resulted in reduced imipramine and elevated desipramine concentrations in the brain. Coadministration of T3 with imipramine appeared to accelerate the desipramine-induced changes in norepinephrine and 3-methoxy-4-hydroxyphenylglycol concentrations in brain. Since T3 treatment elevated the 5-hydroxyindole acetic acid concentration in the brain, the concentration in rats receiving both drugs was equivalent to that of vehicle-treated rats.
Suzuki
S
S
Department of Neuropsychiatry, Aichi Medical College, Japan.
Yoshida
T
T
Sugita
S
S
Kobayashi
A
A
Nakazawa
K
K
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001711:Biotransformation; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003891:Desipramine / Q000378:metabolism*; D006207:Half-Life; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D014284:Triiodothyronine / Q000494:pharmacology*
D015306:Biogenic Monoamines; D014284:Triiodothyronine; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D007099:Imipramine; D003891:Desipramine; D009638:Norepinephrine