title: Effect of an inelastic aortic synthetic vascular graft on exercise hemodynamics.
abstract: This study compared aortic input impedance characteristics between patients with aortic interposition Dacron grafts placed for traumatic aortic injury and normal age-matched control subjects. All subjects were examined at rest and after treadmill exercise. Magnetic resonance imaging was conducted to rule out anatomic (stenosis) effects. Exercise increased characteristic impedance (ie, reduced aortic distensibility) by 29% and decreased total systemic arterial compliance by 21% in the patient group, whereas the normal control group showed insignificant change in these variables after exercise. Peripheral pressure wave reflection was reduced substantially with exercise (27%) in the control group, with much less reduction observed in the patient group. These abnormal vascular hemodynamics were associated with significantly high cardiac energetic costs in the patient group. A plausible explanation for the observed differences lies in the exaggerated vascular impedance mismatch between compliant aorta and inelastic graft, when cardiac output increases dramatically.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Loyola University Medical Center, Maywood, Illinois 60153.
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: T J
authors.initials: TJ
authors.lastname: Hinkamp
authors.forename: W R
authors.initials: WR
authors.lastname: Jacobs
authors.forename: R C
authors.initials: RC
authors.lastname: Lichtenberg
authors.forename: H
authors.initials: H
authors.lastname: Posniak
authors.forename: R
authors.initials: R
authors.lastname: Pifarré
mesh_terms: D000328:Adult; D001013:Aorta, Thoracic / Q000502:physiology* / Q000601:surgery; D001807:Blood Vessel Prosthesis; D003187:Compliance; D005080:Exercise Test; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D010992:Plethysmography, Impedance; D011673:Pulsatile Flow / Q000502:physiology*; D012039:Regional Blood Flow; D016277:Ventricular Function, Left / Q000502:physiology