Synthesis and hypnotic activity of some 2-thioxo-4,5-imidazolidinedione derivatives.
Several 1-Substituted benzylideneamino-2-thioxo-4,5-imidazolidinedione derivatives were synthesized 2a-i, characterized and evaluated for hypnotic activity. The tested compounds increased the sleeping time to a significant value (p < 0.001).
Ozkirimli
S
S
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Hamali
O
O
D000818:Animals; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice
D006993:Hypnotics and Sedatives; D007093:Imidazoles