[The localization of alpha-fetoprotein and the gap-junction protein Cx32 in the regenerating mouse liver].
The data on distribution of alpha-fetoprotein (AFP) and gap junction protein Cx32 in mouse liver regenerating after carbon tetrachloride poisoning are presented. On the second day, when a significant number of AFP-positive cells appear in the liver, Cx32-specific staining was lost from major part of the "intact" parenchyma. On the third day numerous AFP-positive cells could be localized only in the narrow perinecrotic area. By that time, Cx32-specific staining appeared again in major part of liver parenchyma except perinecrotic areas where AFP-containing cells were located. The number of Cx32-negative cells always exceeded that of AFP-positive cells. The latter, however, were always located in Cx32-negative areas. Thus, correlation between appearance of AFP in adult hepatocytes in vivo and disturbance of gap junctions was observed which was described earlier in cultured adult hepatocytes.
Staroverov
D B
DB
Gleĭberman
A S
AS
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D017630:Connexins; D005260:Female; D007150:Immunohistochemistry; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects / Q000502:physiology*; D008565:Membrane Proteins / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D000509:alpha-Fetoproteins / Q000187:drug effects / Q000378:metabolism*
D017630:Connexins; D008565:Membrane Proteins; D000509:alpha-Fetoproteins