The "trap" hypothesis of venous ulceration.
The pathogenesis of venous ulceration is unknown. We propose that macromolecules leaking into the dermis as a result of venous hypertension bind to or "trap" growth factors and matrix material, which then become unavailable for tissue repair and for the maintenance of tissue integrity.
Falanga
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University of Miami School of Medicine, Department of Dermatology and Cutaneous Surgery, Florida 33101.
Eaglstein
W H
WH
D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D014647:Varicose Ulcer / Q000209:etiology*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D006133:Growth Substances; D046911:Macromolecular Substances; D000511:alpha-Macroglobulins; D005337:Fibrin; D005340:Fibrinogen