Malignant lymphoma originating from the earliest T-lineage precursor cell.
The earliest T-lineage precursor cells with a CD3-CD4+CD8- phenotype and germline-state T-cell receptor (TCR) genes have recently been identified in the murine thymus. We report a case of malignant lymphoma that was considered to originate from the human counterpart of this newly defined murine T-cell population. The surface phenotype of the lymphoma cells was CD2+CD3-CD4+CD8-CD25-CD34-CD44+HLA-DR+. TCR-beta, -gamma, -delta chain genes and immunoglobulin heavy and light chain genes were all in a germline state. These characteristics were markedly similar to those of the murine earliest T-lineage precursor cells. The present case thus strongly suggests the presence of the human counterpart of this novel murine T-cell population.
Hashimoto
Y
Y
First Department of Internal Medicine, Ehime University School of Medicine, Japan.
Yasukawa
M
M
Takada
K
K
Hato
T
T
Fujita
S
S
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34; D017252:CD3 Complex / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor / Q000235:genetics; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000032:analysis / Q000235:genetics; D008223:Lymphoma / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D008297:Male; D010641:Phenotype; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis / Q000235:genetics; D015375:Receptors, Interleukin-2 / Q000032:analysis; D016201:Receptors, Lymphocyte Homing / Q000032:analysis; D013234:Stem Cells / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology / Q000473:pathology*
D015703:Antigens, CD; D018952:Antigens, CD34; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D015375:Receptors, Interleukin-2; D016201:Receptors, Lymphocyte Homing