Hereditary cerebellar vermis defect in the Lewis rat.
We report a new rat model of hereditary cerebellar vermis defect. Mutant rats exhibited hind-leg paralysis from about 14 days old. Gross pathology showed the cerebellar vermis defect, fused cerebellar hemispheres and cyst formation. Ectopic dysplastic cerebellar tissues existed in the cerebello-pontine junctional zones. Mild disarrangement of lamination was also observed in the fused cerebellar hemispheres. The present mutant may serve as a valid model for studying the cerebellar vermis defect under the genetic control.
Kuwamura
M
M
Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Japan.
Yoshida
T
T
Yamate
J
J
Kotani
T
T
Sakuma
S
S
D000818:Animals; D002531:Cerebellum / Q000002:abnormalities* / Q000473:pathology; D003616:Dandy-Walker Syndrome / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D010375:Pedigree; D051381:Rats; D011917:Rats, Inbred Lew