title: Urinary bladder carcinoma producing granulocyte colony stimulating factor (G-CSF): a case report with immunohistochemistry.
abstract: A rare case of urinary bladder carcinoma with granulocyte colony stimulating factor (G-CSF) production was reported. In an 83-year-old female, marked neutrophilia in the peripheral blood decreased from 132,500/mm3 to 3,300/mm3 after tumour resection. The tumour was a transitional cell carcinoma. The serum G-CSF level reduced from 238 pg/ml pre-operatively to normal (60 pg/ml) after the operation. Immunohistochemical investigation of the resected tumour with monoclonal antibody specific for G-CSF revealed positive staining in the carcinoma cells, confirming G-CSF secretion.
authors.affiliation: Division of Internal Medicine, Nippon Kokan Hospital, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Shimamura
authors.forename: K
authors.initials: K
authors.lastname: Shoji
authors.forename: A
authors.initials: A
authors.lastname: Akatsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Kiryu
authors.forename: N
authors.initials: N
authors.lastname: Tamaoki
authors.forename: Y
authors.initials: Y
authors.lastname: Osamura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D016179:Granulocyte Colony-Stimulating Factor