Synthesis and biological activity of carboxyphenylquinolines and related compounds as new potent retinoids. Retinobenzoic acids. VII.
A series of new quinoline, quinolone, and quinazolinedione derivatives was synthesized and tested for retinoid activity in the human promyelocytic cell line HL-60 differentiation assay. All the quinoline compounds exhibited significant activity, depending on the substituent on the heterocycle. However, the quinolone and quinazolinedione derivatives were poor inducers of the differentiation of the HL-60 cells, the activity depending strongly on the polarity of the molecule.
Eyrolles
L
L
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Kawachi
E
E
Kagechika
H
H
Hashimoto
Y
Y
Shudo
K
K
D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D019817:Benzoic Acid; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D008934:Mitogens / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014212:Tretinoin / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D001565:Benzoates; D008934:Mitogens; D014212:Tretinoin; D019817:Benzoic Acid