Aspirin and anticonvulsant interaction.
Aspirin (360 mg/kg, po) per se had anticonvulsant activity in MES model. No effect was observed at lower doses and in other models. Aspirin 216 mg/kg, po (a subanticonvulsant dose) protected animals, receiving subanticonvulsant doses of phenytoin, phenobarbitone and carbamazepine against MES.
Wali
R S
RS
Department of Pharmacology, Jawaharlal Nehru Medical College, Belgaum.
Patil
P A
PA
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004357:Drug Synergism; D004597:Electroshock / Q000009:adverse effects; D005260:Female; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology / Q000627:therapeutic use*; D010672:Phenytoin / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012640:Seizures / Q000188:drug therapy* / Q000517:prevention & control
D002220:Carbamazepine; D010672:Phenytoin; D001241:Aspirin; D010634:Phenobarbital