Clozapine-induced agranulocytosis and colony-stimulating cytokines.
A case of clozapine-induced agranulocytosis that was treated with a granulocyte colony-stimulating cytokine is presented. The hematological status normalized. Two colony-stimulating factors are marketed for activating bone marrow function. Their utility in clozapine a granulocytoses is not clear, but they offer a potential new therapeutic option.
Ryabik
B M
BM
Department of Psychiatry and Behavioral Sciences, University of Louisville, School of Medicine, Kentucky.
Nguyen
V T
VT
Mann
R M
RM
Smith
J D
JD
Lippmann
S B
SB
D000380:Agranulocytosis / Q000139:chemically induced* / Q000276:immunology / Q000628:therapy; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D011994:Recombinant Proteins / Q000008:administration & dosage; D012559:Schizophrenia / Q000188:drug therapy* / Q000276:immunology
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003024:Clozapine