title: A morbillivirus that caused fatal disease in horses and humans.
abstract: A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a "double-fringed" appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs.
authors.affiliation: CSIRO Australian Animal Health Laboratory, East Geelong, Victoria.
authors.forename: K
authors.initials: K
authors.lastname: Murray
authors.forename: P
authors.initials: P
authors.lastname: Selleck
authors.forename: P
authors.initials: P
authors.lastname: Hooper
authors.forename: A
authors.initials: A
authors.lastname: Hyatt
authors.forename: A
authors.initials: A
authors.lastname: Gould
authors.forename: L
authors.initials: L
authors.lastname: Gleeson
authors.forename: H
authors.initials: H
authors.lastname: Westbury
authors.forename: L
authors.initials: L
authors.lastname: Hiley
authors.forename: L
authors.initials: L
authors.lastname: Selvey
authors.forename: B
authors.initials: B
authors.lastname: Rodwell
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002522:Chlorocebus aethiops; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000453:epidemiology / Q000401:mortality / Q000821:virology*; D006736:Horses; D006801:Humans; D007668:Kidney / Q000821:virology; D008168:Lung / Q000821:virology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D018103:Morbillivirus / Q000235:genetics / Q000302:isolation & purification*; D018185:Morbillivirus Infections / Q000453:epidemiology / Q000401:mortality / Q000662:veterinary* / Q000821:virology*; D011247:Pregnancy; D011793:Queensland / Q000453:epidemiology; D012141:Respiratory Tract Infections / Q000662:veterinary / Q000821:virology; D013154:Spleen / Q000821:virology; D014709:Vero Cells; D014776:Virus Cultivation