Nicotine enhances dopamine clearance in rat nucleus accumbens.
1. Adult male rats were urethane-anesthetized and prepared for acute in-vivo voltammetric recording in the nucleus accumbens. 2. Small amounts of 200 uM dopamine were pressure ejected near the tip of the recording electrode at 5-min intervals, while the peak concentration and time course of dopamine clearance were measured voltammetrically. 3. After stable peak amplitudes were established, nicotine (0.4 mg/kg) was injected systemically. 4. Dopamine peak amplitudes decreased following nicotine injection, presumably due to enhanced dopamine reuptake.
Ksir
C
C
Department of Psychology, University of Wyoming, Laramie, USA.
Mellor
G
G
Hart
C
C
Gerhardt
G A
GA
D000818:Animals; D004298:Dopamine / Q000378:metabolism* / Q000493:pharmacokinetics; D004347:Drug Interactions; D008297:Male; D009538:Nicotine / Q000378:metabolism / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D009538:Nicotine; D004298:Dopamine