title: The intrinsic and vagal extrinsic innervation of the rat stomach contains nitric oxide synthase.
abstract: Nitric oxide synthase (NOS) associated with the intrinsic and vagal extrinsic innervation of the rat gastric corpus was studied in both control and neonatally capsaicin-treated animals. Nerve cell bodies and fibres of both the myenteric and sub-mucosal plexi of the gastric corpus was found to contain NOS, but were distinct from those containing VIP. NOS-positive fibres were seen innervating the circular smooth muscle layer. Stain accumulated both proximal and distal to a vagal ligature. Staining of the nucleus of the solitary tract (NTS) was associated with specific sub-nuclei. Neonatal capsaicin treatment did not alter the staining in the NTS, vagus nerve or stomach. The data presented here support the idea that NO is a non-adrenergic non-cholinergic transmitter associated with gastric function.
authors.affiliation: Physiological Laboratory, University of Liverpool, UK.
authors.forename: E R
authors.initials: ER
authors.lastname: Forster
authors.forename: E
authors.initials: E
authors.lastname: Southam
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001933:Brain Stem / Q000033:anatomy & histology / Q000201:enzymology; D002211:Capsaicin / Q000494:pharmacology; D005260:Female; D006651:Histocytochemistry; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000201:enzymology; D009046:Motor Neurons / Q000187:drug effects; D009252:NADPH Dehydrogenase / Q000032:analysis; D009475:Neurons, Afferent / Q000187:drug effects; D019001:Nitric Oxide Synthase; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000201:enzymology / Q000294:innervation*; D014628:Vagotomy; D014630:Vagus Nerve / Q000201:enzymology*; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
chemical_list: D014660:Vasoactive Intestinal Peptide; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D009252:NADPH Dehydrogenase; D002211:Capsaicin