title: Chronic neutrophilic leukemia--a case report.
abstract: We describe a 77-year-old patient with chronic neutrophilic leukemia (CNL). Diagnosis of CNL was made by marked increase of mature neutrophils without increased immature granulocytes, splenomegaly and elevated serum vitamin B12 level and by ruling out any infection or occult malignancy. The chromosome analysis showed one abnormal karyotype out of 14 metaphases. The neutrophilic function with nitroblue tetrazolium test revealed impaired phagocytic function in this patient. The neutrophil count became normal gradually after hydroxyurea treatment. However, it still maintained a high percentage of mature neutrophils. Background literature and the prognosis of CNL are discussed.
authors.affiliation: Division of Hemato-oncology, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: C S
authors.initials: CS
authors.lastname: Chang
authors.forename: S F
authors.initials: SF
authors.lastname: Lin
authors.forename: S M
authors.initials: SM
authors.lastname: Hwang
authors.forename: T C
authors.initials: TC
authors.lastname: Liu
authors.forename: T P
authors.initials: TP
authors.lastname: Chen
authors.forename: W
authors.initials: W
authors.lastname: Chiang
mesh_terms: D000368:Aged; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D015467:Leukemia, Neutrophilic, Chronic / Q000097:blood* / Q000188:drug therapy; D008297:Male; D009504:Neutrophils / Q000502:physiology
chemical_list: D006918:Hydroxyurea