Phylogenetic relationships among transposon-like elements in human and primate DNA.
A THE-1 sequence in intron 7 of the human dystrophin gene has been found to represent a new subfamily of THE-1 elements. The sequence is closely related to the MstII family of repetitive sequences and is more like single-copy sequences found in the galago genome than any other THE-1 sequence previously reported. This new THE-1 sequence has been compared with two other complete THE-1 sequences and three related long-terminal repeat elements that we have previously found in intron 7 of the dystrophin gene, and with members of the same family from elsewhere in the primate genome. Parsimony and deletion analysis show that the cluster of THE-1 sequences in intron 7 of the dystrophin gene has arisen from at least three individual insertion events, rather than from the insertion and duplication of a single progenitor sequence.
McNaughton
J C
JC
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
Marshall
C J
CJ
Broom
J E
JE
Hughes
G
G
Jones
W A
WA
Stockwell
P A
PA
Petersen
G B
GB
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D004251:DNA Transposable Elements / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011323:Primates / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion
D004251:DNA Transposable Elements; D004247:DNA