[Effects of endothelin-1 on the smooth muscle contractility of human urinary bladder, spermatic cord and prostatic adenoma].
Effects of endothelin-1 (ET-1) on the smooth muscle contractility of human detrusor, spermatic cord and hypertrophied prostatic adenoma were examined in muscle bath studies. ET-1 increased the contractile forces of all above smooth muscle strips in concentration dependent manner. The contractile force induced by 10(-6) M ET-1 was approximately 30% of that induced by 3 x 10(-5) M carbachol in detrusor muscle strips, approximately 40% of that induced by 10(-4) M norepinephrine in spermatic cord muscle strips and almost equal to that induced by 10(-5) M phenylephrine in prostatic adenoma muscle strips. The contractions induced by ET-1 in those muscle strips were not inhibited by any of tetrodoxine, atropine, phentolamine, propranolol and indomethacine. These results suggest that ET-1 may act as a constrictor on lower urinary tract and genital smooth muscles and especially on prostatic adenoma and that ET-1 may affect those smooth muscles directly not through autonomic receptors or prostaglandins.
Morita
T
T
Department of Urology, Tokyo Medical and Dental University School of Medicine.
Ando
M
M
Kihara
K
K
Matsumura
T
T
Kamai
T
T
Oshima
H
H
Tsuchiya
N
N
Kondo
S
S
D000368:Aged; D016232:Endothelins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011467:Prostate / Q000503:physiopathology; D011470:Prostatic Hyperplasia / Q000503:physiopathology*; D013085:Spermatic Cord / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*
D016232:Endothelins