title: Captopril attenuates pacing-induced acute heart failure by increasing total vascular capacitance.
abstract: To study the effects of captopril pretreatment on vascular capacitance in acute heart failure, anesthetized splenectomized dogs were subjected to rapid right ventricular pacing (RRVP) at 250 beats/min for 60 min combined with an intravenous (i.v.) 20-ml/kg volume load of dextran 70 over 10 min. Captopril pretreatment [50 mg every 8 h for 3 days plus 0.5 mg/kg intravenously (i.v.) at induction of anesthesia] attenuated development of acute heart failure associated with RRVP, maintaining normal cardiac output (CO) and pulmonary capillary wedge pressures (PCWP). Total vascular capacitance after a volume load plus RRVP was higher in captopril-pretreated animals (129.8 +/- 3.2 vs. 100.4 +/- 4.8 ml/kg) owing to an increase in unstressed volume (118.6 +/- 3.1 vs. 88.4 +/- 5.6 ml/kg). Arterial capacity and pulmonary (central) vascular capacitance were also increased.
authors.affiliation: Clinical Pharmacology Service, Toronto Hospital, Ontario, Canada.
authors.forename: R I
authors.initials: RI
authors.lastname: Ogilvie
authors.forename: D
authors.initials: D
authors.lastname: Zborowska-Sluis
mesh_terms: D000208:Acute Disease; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D003187:Compliance; D004195:Disease Models, Animal; D004285:Dogs; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D010138:Pacemaker, Artificial; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D002216:Captopril