Differential SAR of quinuclidine SP antagonists between rat and human-type receptors.
Snider
R M
RM
Central Research Division, Pfizer Inc., Groton, CT.
Longo
K P
KP
Zorn
S H
SH
Morrone
J
J
Jackson
E R
ER
Nagahisa
A
A
Kanai
Y
Y
Suga
O
O
Nakagaki
M
M
Drozda
S E
SE
D000818:Animals; D006801:Humans; D015394:Molecular Structure; D064729:Neurokinin-1 Receptor Antagonists; D011812:Quinuclidines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013373:Substance P / Q000037:antagonists & inhibitors / Q000378:metabolism*
D064729:Neurokinin-1 Receptor Antagonists; D011812:Quinuclidines; D018040:Receptors, Neurokinin-1; D013373:Substance P