title: Vacuum phenomena in insufficiency fractures of the sacrum.
abstract: OBJECTIVE
  Insufficiency fractures of the sacrum are found in women who have undergone radiation therapy to the lower abdomen as well as those suffering from osteoporosis of postmenopausal, steroid-induced, or primary biliary cirrhosis-related origin. Increased uptake in bone scintigraphy and osteolytic changes in these fractures can be misinterpreted as bone metastases, leading to unnecessary biopsies and other procedures in the ensuing search for non-existent primary tumor.
  
  
  METHODS
  In eight female patients averaging 69.4 years of age, insufficiency fracture of the sacrum was diagnosed by computed tomography (CT) and bone scintigraphy. Three underwent a total of five MRI examinations. Malignancy was excluded by histology in two patients and follow-up of at least 6 months in the remainder. Retrospective analysis of CT scans of 13 patients with metastases in the sacrum revealed no vacuum phenomena.
  
  
  RESULTS
  In seven of eight patients with insufficiency fracture of the sacrum, vacuum phenomena were shown on CT examination. The gas was localized centrally within the ventral part of the fracture in three patients; gas was located in ten adjacent sacro-iliac joints of six patients.
  
  
  CONCLUSIONS
  The vacuum phenomenon may be an incidental finding in osteoarthritis of the sacro-iliac joint, but it has not been previously recognized in IFS. The presence of intra-articular vacuum phenomena in the sacro-iliac joints in combination with a sacral fracture and vacuum phenomena located within the sacral fracture supports a diagnosis of insufficiency fracture or may indeed be the clue by which this diagnosis is established.
authors.affiliation: Institute of Diagnostic Radiology, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Stäbler
authors.forename: R
authors.initials: R
authors.lastname: Beck
authors.forename: R
authors.initials: R
authors.lastname: Bartl
authors.forename: D
authors.initials: D
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D003937:Diagnosis, Differential; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D005682:Gadolinium; D019786:Gadolinium DTPA; D005740:Gases; D006801:Humans; D008279:Magnetic Resonance Imaging; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011856:Radiographic Image Enhancement; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging / Q000473:pathology; D012447:Sacrum / Q000000981:diagnostic imaging / Q000293:injuries* / Q000528:radiation effects; D016103:Spinal Fractures / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014618:Vacuum
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D005740:Gases; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA