title: Primary common bile duct anastomosis in the rat using microsurgical techniques.
abstract: In a rat model, we attempted to describe the natural healing course of the common bile duct (CBD) after primary microsurgical repair. Fifty-three rats were divided into experimental groups with CBD microsurgical anastomoses and control groups with CBD mobilization and ligation. Examination of three experimental groups at 1 week, 1 month, and 3 months showed evolving inflammation and stricture changes with eventual patent, healed ducts in 92% of animals at the end of 3 months following transection and repair. There were no histologic abnormalities in the livers. There were fibrotic ducts and hepatic stasis and cirrhosis changes in the control group with CBD ligation. This study demonstrates that microsurgical techniques can achieve successful primary biliary repair in the rat.
authors.affiliation: Division of Microsurgical Replantation-Transplantation, Davies Medical Center, San Francisco, California, USA.
authors.forename: C
authors.initials: C
authors.lastname: Chansmorn
authors.forename: W C
authors.initials: WC
authors.lastname: Lineaweaver
authors.forename: H
authors.initials: H
authors.lastname: Tonken
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Campagna-Pinto
authors.forename: L
authors.initials: L
authors.lastname: Newlin
authors.forename: K
authors.initials: K
authors.lastname: Yim
authors.forename: H J
authors.initials: HJ
authors.lastname: Buncke
mesh_terms: D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000379:methods*; D000818:Animals; D002761:Cholangitis / Q000209:etiology; D002779:Cholestasis / Q000209:etiology; D003135:Common Bile Duct / Q000473:pathology / Q000601:surgery*; D003137:Common Bile Duct Diseases / Q000209:etiology; D003251:Constriction, Pathologic / Q000209:etiology; D004108:Dilatation, Pathologic / Q000209:etiology; D004195:Disease Models, Animal; D005355:Fibrosis; D008026:Ligation / Q000009:adverse effects; D008106:Liver Cirrhosis, Experimental / Q000209:etiology; D008297:Male; D008866:Microsurgery / Q000009:adverse effects / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D015996:Survival Rate; D013997:Time Factors; D014945:Wound Healing