title: Effect of intrinsic CCK and CCK antagonist on pancreatic growth and pancreatic enzyme secretion in pancreaticobiliary diversion rats.
abstract: When pancreaticobiliary diversion (PBD) surgery was performed in rats, plasma CCK level increased, the pancreas grew mainly by proliferation, and pancreatic trypsinogen showed a remarkable increase, although amylase and lipase synthesis were somewhat decreased. The sensitivity of amylase release against CCK-8 in the pancreatic acini decreased when plasma CCK level was high. These changes in pancreatic growth and pancreatic enzyme secretion caused by PBD were completely inhibited by the CCK-receptor antagonist loxiglumide. From these results, intrinsic CCK was considered to play an important role in both pancreatic enzyme synthesis and proliferation.
authors.affiliation: Second Department of Internal Medicine, Shiga University of Medical Science, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Bamba
authors.forename: Y
authors.initials: Y
authors.lastname: Ishizuka
authors.forename: S
authors.initials: S
authors.lastname: Hosoda
mesh_terms: D000681:Amylases / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001662:Biliary Tract Surgical Procedures / Q000379:methods*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000097:blood / Q000494:pharmacology*; D006984:Hypertrophy / Q000139:chemically induced / Q000201:enzymology; D008049:Lipase / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D011377:Proglumide / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012633:Secretin / Q000097:blood / Q000187:drug effects; D013997:Time Factors; D014362:Trypsinogen / Q000187:drug effects / Q000378:metabolism
chemical_list: D012633:Secretin; C053737:loxiglumide; D014362:Trypsinogen; D002766:Cholecystokinin; D008049:Lipase; D000681:Amylases; D011377:Proglumide