Antinociceptive properties and inhibition of neurogenic inflammation with potent SP antagonists belonging to perhydroisoindolones.
Garret
C
C
Rhone-Poulenc Rorer, Centre de Recherches de Vitry-Alfortville, Vitry-sur-Seine, France.
Carruette
A
A
Fardin
V
V
Moussaoui
S
S
Montier
F
F
Peyronel
J F
JF
Laduron
P M
PM
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology*; D054833:Isoindoles; D018041:Receptors, Neurokinin-2 / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013373:Substance P / Q000037:antagonists & inhibitors*; D015320:Tachykinins / Q000494:pharmacology*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D054833:Isoindoles; D018041:Receptors, Neurokinin-2; D015320:Tachykinins; C071693:7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one; D013373:Substance P