The effect of caffeine on prostaglandin output from the perfused mesenteric vascular bed of the rat.
Caffeine significantly (p < 0.05) increased the output of prostacyclin (PGI2) from the perfused rat mesenteric vascular bed. The outputs of PGE2 and PGF2 alpha were also increased by caffeine. This stimulatory response to caffeine did not show rapid desensitization. Ryanodine also increased PG output, suggesting that caffeine may be acting via the stimulation of a ryanodine receptor. The increased production of a vasodilator such as PGI2 from blood vessels following exposure to caffeine may explain why caffeine has a beneficial effect in angina.
Naderali
E K
EK
Department of Pharmacology, University of Edinburgh Medical School, UK.
Poyser
N L
NL
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000787:Angina Pectoris / Q000503:physiopathology; D000818:Animals; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D011464:Epoprostenol / Q000378:metabolism; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000378:metabolism; D008642:Mesenteric Veins / Q000187:drug effects* / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D010477:Perfusion; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D012433:Ryanodine / Q000494:pharmacology; D013268:Stimulation, Chemical
D011453:Prostaglandins; D012433:Ryanodine; D002110:Caffeine; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D011464:Epoprostenol; D015232:Dinoprostone