Autoantibodies in Parry-Romberg syndrome: a serologic study of 14 patients.
OBJECTIVE
To determine autoantibody profiles of patients with Parry-Romberg syndrome (PRS).


METHODS
Antinuclear antibodies (ANA) in 14 patients with PRS were studied by indirect immunofluorescence (IIF), immunodiffusion and immunoblotting. Antinative DNA antibodies and rheumatoid factor (RF) were also analyzed.


RESULTS
ANA were positive in 8 patients (57%). The patterns of staining included nucleolar, nuclear speckled and homogeneous. Anticentromere antibodies were observed in 2 and antihistone antibodies in 3 sera. Rheumatoid factor was found in 5 (36%) sera. Antinative DNA or antibodies that precipitated rabbit thymus extract were not found in any patients.


CONCLUSIONS
The serologic abnormalities observed in this study suggests that autoimmunity could play a pathogenic role in PRS.
Garcia-de la Torre
I
I
Department of Immunology and Rheumatology, Hospital General de Occidente de la Secretaria de Salud, Zapopan, Mexico.
Castello-Sendra
J
J
Esgleyes-Ribot
T
T
Martinez-Bonilla
G
G
Guerrerosantos
J
J
Fritzler
M J
MJ
D000293:Adolescent; D000328:Adult; D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood*; D000953:Antigens, Protozoan; D002503:Centromere / Q000276:immunology; D002648:Child; D003421:Crithidia; D005260:Female; D006657:Histones / Q000276:immunology; D006801:Humans; D015151:Immunoblotting; D015994:Incidence; D008297:Male; D012217:Rheumatoid Factor / Q000097:blood; D012594:Scleroderma, Localized / Q000097:blood / Q000276:immunology*
D000974:Antibodies, Antinuclear; D000953:Antigens, Protozoan; D006657:Histones; D012217:Rheumatoid Factor