Occlusive and reperfused myocardial infarction: detection by using MR imaging with gadolinium polylysine enhancement.
OBJECTIVE
To assess the capability of gadolinium polylysine-enhanced cardiac magnetic resonance (MR) imaging in depicting normal and ischemic myocardium during occlusion and reperfusion of the left anterior descending artery.


METHODS
Contrast-enhanced MR images were obtained in 18 cats during 90 minutes each of occlusion and reperfusion. The change in signal intensity (SI) was compared among normal myocardium and central and peripheral ischemic zones. Results were compared with those of 2,3,5-triphenyltetrazolium chloride staining.


RESULTS
During occlusion, the ischemic zone lacked enhancement while normal myocardium had gradual enhancement. During reperfusion, the ischemic zone had strong enhancement. In cats with large infarction, the central and peripheral ischemic zones had intermediate and high SI, respectively; in cats with focal or no infarction, the entire ischemic zone had high SI.


CONCLUSIONS
Occlusive and reperfused myocardial infarction can be detected at gadolinium polylysine-enhanced MR imaging by means of differential SI changes in normal myocardium and central and peripheral ischemic zones.
Lim
T H
TH
Department of Radiology, Asan Medical Center, SongPa-Ku, Seoul, Korea.
Lee
D H
DH
Kim
Y H
YH
Park
S W
SW
Park
P H
PH
Seo
D M
DM
Kim
S T
ST
Lee
T K
TK
Mun
C W
CW
D000818:Animals; D002415:Cats; D003287:Contrast Media; D005682:Gadolinium; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009203:Myocardial Infarction / Q000175:diagnosis*; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology*; D009942:Organometallic Compounds; D011107:Polylysine / Q000031:analogs & derivatives*; D013194:Staining and Labeling; D013778:Tetrazolium Salts
D003287:Contrast Media; D009942:Organometallic Compounds; D013778:Tetrazolium Salts; D011107:Polylysine; C009591:triphenyltetrazolium; C064954:gadopentetate dimeglumine polylysine; D005682:Gadolinium