Human breast cancer: prognostic significance of DNA ploidy compared with c-erbB2 expression, Cathepsin D and silver-binding nucleolar organizer regions (AgNORs).
We evaluated breast cancer specimens from 150 patients after a follow-up more than 10 years, by means of DNA flow cytometry, immunohistochemistry (cerbB2 and Cathepsin D) and argyrophilic (AgNORs) methods. In univariate analysis all indexes studied provide prognostic information about the disease free survival, whereas in the multivariate Cox model the DNA Index is the most important prognostic factor. We conclude that the data obtained from DNA flow cytometry, associated with other parameters, can be of greatest importance for the decision an the level of aggressiveness of adjuvant therapy for the decision an the level of aggressiveness of adjuvant therapy for a individual patients.
Borgiani
L
L
Servizio di Anatomia Patologica, E.O. Ospedali Galliera.
Cogorno
P
P
Buccaran
G
G
Gallo
L
L
Rovida
S
S
Canepa
M
M
D000782:Aneuploidy; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D002402:Cathepsin D / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis*; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000032:analysis*; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D016016:Proportional Hazards Models; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D016196:S Phase; D016622:Silver Staining
D014408:Biomarkers, Tumor; D002402:Cathepsin D; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases