Urinary alpha 1-microglobulin as an index of proximal tubular function in early infancy.
Urinary alpha 1-microglobulin (U-A1M) was measured in healthy term infants on days 1, 4, 7, 14, 28, 90 and 180 of life. U-A1M was high until day 14 and declined thereafter. It was significantly correlated with urinary beta 2-microglobulin (U-B2M) throughout the study, but not with serum A1M on days 1 or 7. Similar to U-B2M, U-A1M in the clinically stable term infants with intrauterine growth retardation (n = 4-7) was not elevated on days 1-7. In the sick infants who needed immediate resuscitation at birth (n = 4-8), U-A1M was well as U-B2M was high on days 1-7 and then decreased to normal levels, suggesting that U-A1M can be used as a sensitive marker of acute proximal tubular damage and its recovery. These observations indicate that U-A1M is a useful index of proximal tubular function in early infancy.
Tsukahara
H
H
Department of Paediatrics, Fukui Medical School, Japan.
Hiraoka
M
M
Kuriyama
M
M
Saito
M
M
Morikawa
K
K
Kuroda
M
M
Tominaga
T
T
Sudo
M
M
D000510:Alpha-Globulins / Q000652:urine*; D015415:Biomarkers; D005317:Fetal Growth Retardation / Q000652:urine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000652:urine; D007674:Kidney Diseases / Q000503:physiopathology; D007677:Kidney Function Tests; D007687:Kidney Tubules, Proximal / Q000503:physiopathology*; D011480:Protease Inhibitors / Q000652:urine*; D012016:Reference Values; D001613:beta 2-Microglobulin / Q000652:urine
D000510:Alpha-Globulins; D015415:Biomarkers; D011480:Protease Inhibitors; C016001:alpha-1-microglobulin; D001613:beta 2-Microglobulin