Inhibition of hepatitis B virus in tissue culture by alpha interferon.
Alpha-n1 interferon (Wellferon), alpha-2a interferon (Roferon), and alpha-2b interferon (Intron-A) inhibited accumulation of intracellular replicative forms of hepatitis B virus (HBV) in chronic producer cells by inhibiting accumulation of RNase-resistant HBV RNA. In contrast, the nucleoside analog FTC (cis-5-fluoro-1- [2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine) inhibited the accumulation of HBV DNA.
Davis
M G
MG
Division of Virology, Burroughs Wellcome Co., Research Triangle Park, North Carolina.
Jansen
R W
RW
D002460:Cell Line; D004279:DNA, Viral / Q000037:antagonists & inhibitors; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics; D016898:Interferon-alpha / Q000494:pharmacology*; D012367:RNA, Viral / Q000378:metabolism
D004279:DNA, Viral; D016898:Interferon-alpha; D012367:RNA, Viral