Effects of SDZ ENA 713, novel acetyl cholinesterase inhibitor, on learning of rats with basal forebrain lesions.
1. The effects of SDZ ENA 713, a novel acetyl cholinesterase inhibitor, on rat learning was studied using a step-down avoidance paradigm. 2. Injection of ibotenic acid into the caudolateral part of the basal forebrain (BF) innervating cholinergic neurons to the cerebral cortex, resulted in an increase in the number of trials required to obtain 300-second-latency, and also a decrease in the latency period after attaining 300-second-latency. 3. It is shown that the BF-lesioned rats are impaired in both acquisition and retention of learning. 4. Intraperitoneal injection of 0.10-0.05 mg/kg/day SDZ ENA 713 to the BF-lesioned rats showed amelioration of the learning impairment, with a decreased number of trials required to obtain 300-second-latency as well as an increase in the latency time after repeated training. 5. These results indicate that SDZ ENA 713 improves acquisition and retention impairment in BF-lesioned rats, and that this drug may be useful for demented patients with cholinergic dysfunction, such as Alzheimer's disease.
Niigawa
H
H
Department of Neuropsychiatry, Osaka University Medical School, Japan.
Tanimukai
S
S
Takeda
M
M
Hariguchi
S
S
Nishimura
T
T
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002219:Carbamates / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000032:analysis*; D004558:Electric Stimulation; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008124:Locomotion; D048448:Phenylcarbamates; D016548:Prosencephalon / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D000068836:Rivastigmine
D002219:Carbamates; D002800:Cholinesterase Inhibitors; D048448:Phenylcarbamates; D000068836:Rivastigmine