title: Transcriptional activation. Tuning-up transcription.
abstract: Eukaryotic transcription is a complex process, and recent results identify multiple steps that need to be stimulated to activate transcription, one of which is a change in conformation of the general transcription factor TFIIB.
authors.affiliation: Howard Hughes Medical Institute, Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.
authors.forename: M
authors.initials: M
authors.lastname: Sheldon
authors.forename: D
authors.initials: D
authors.lastname: Reinberg
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism; D035181:TATA-Box Binding Protein; D035581:Transcription Factor TFIIB; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D035181:TATA-Box Binding Protein; D035581:Transcription Factor TFIIB; D014157:Transcription Factors; D012319:RNA Polymerase II