Confirmed assignment of a novel human tyrosine kinase gene (JAK1A) to 1p32.3-->p31.3 by nonisotopic in situ hybridization.
JAK1A is a recently isolated class 3 (nonreceptor) tyrosine kinase that has catalytic domain sequence homology with other kinases and is known to be ubiquitously expressed in all human tissues thus far examined. The gene for this enzyme had previously been localized to chromosome 1 using somatic cell hybrids and linkage analyses. In the present study, fluorescence in situ hybridization was utilized to confirm its localization and regionally assign the gene to chromosome region 1p32.3-->p31.3.
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Biological Carcinogenesis and Development Program, Program Resources Inc./DynCorp., NCI-Frederick Cancer Research and Development Center, MD 21702-1201, USA.
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Howard
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D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D017403:In Situ Hybridization; D053613:Janus Kinase 1; D011505:Protein-Tyrosine Kinases / Q000235:genetics*
D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; D053613:Janus Kinase 1