[Stretch-activated channels in renal tubule].
The mechanosensitive (MS) ion channels have been identified in various tissue, including muscle, neuron, egg, kidney cells. The MS channels can be classified into 4 subtypes, i. e. stretch-activated (SA), curvature-sensitive, stretch-inactivated, and shear-stress activated. Channel activity of SA channels was increased in proportion to tension of the patch-membrane, but not to negative pressure of the patch-pipette. Potassium- and cation-selective (SA) channels were found in renal tubules, which were activated by cell-swelling and membrane-stretch. SA potassium channel may be responsible for a K exit pathway from cell. Ca-permeable (SA) cation channel may allow Ca into the cell. They can play an important role for the cell volume regulation.
Kawahara
K
K
Dept. of Physiol., Chiba Univ. School of Med.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002450:Cell Communication; D048429:Cell Size; D006801:Humans; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D007684:Kidney Tubules / Q000166:cytology*; D011188:Potassium / Q000378:metabolism; D013314:Stress, Mechanical
D007473:Ion Channels; D011188:Potassium; D002118:Calcium