Comparative study of SCE induction and cytostatic effects by homo-azasteroidal esters of N,N-bis(2-chloroethyl)aminobenzoic acid in human lymphocytes.
The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biological basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to induce sister-chromatid exchanges (SCEs) and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumor activity of these compounds was observed.
Mourelatos
D
D
Department of General Biology and Genetics, Medical School, Aristotle University, Thessaloniki, Greece.
Mylonaki
E
E
Papageorgiou
A
A
Boutis
L
L
Paradelis
A
A
Anastasiou
A
A
Catsoulacos
P
P
D000970:Antineoplastic Agents / Q000494:pharmacology; D001378:Azasteroids / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D009153:Mutagens / Q000737:chemistry / Q000494:pharmacology*; D009588:Nitrogen Mustard Compounds / Q000737:chemistry / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000970:Antineoplastic Agents; D001378:Azasteroids; D009153:Mutagens; D009588:Nitrogen Mustard Compounds