Glycosylation of acute phase proteins and interleukins following hip arthroplasty. Inflammation parameters studied in 10 patients.
We analyzed changes in glycosylation and serum concentrations of alpha 1-acid glycoprotein (AGP), antichymotrypsin (AC), interleukin-6 (IL-6), soluble interleukin-2 receptor (sIL-2R) and C-reactive protein (CRP) following hip arthroplasty. Glycosylation of AGP and AC showed an increased reactivity to concanavalin A between postoperative Day 2 and Day 5 and Day 10, respectively. Serum levels of AGP and AC increased at the earliest on Day 5. The AC levels returned to baseline by Day 10. AGP, however, exhibited increased values beyond Day 14. CRP levels were elevated at Day 2 and remained increased beyond Day 14. sIL2R showed increased values at Days 5, 10 and 14. IL-6 was the first parameter to increase, and it returned to baseline in less than 5 days.
Fassbender
K
K
Hochrheininstitut of Rheumatism Research, Bad Säckingen, Germany.
Gerber
B
B
Karrer
U
U
Sobieska
M
M
Aeschlimann
A
A
Müller
W
W
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000209:etiology / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006031:Glycosylation; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D000514:alpha 1-Antichymotrypsin / Q000097:blood
D000209:Acute-Phase Proteins; D015850:Interleukin-6; D015375:Receptors, Interleukin-2; D000514:alpha 1-Antichymotrypsin