The syntaxin family of vesicular transport receptors.
Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. A family of syntaxin-related proteins from rat has been identified that shares 23%-84% amino acid identity. Each of the six syntaxins terminate with a carboxy-terminal hydrophobic domain that anchors the protein on the cytoplasmic surface of cellular membranes. The syntaxins display a broad tissue distribution and, when expressed in COS cells, are targeted to different subcellular compartments. Microinjection studies suggest that the nervous system-specific syntaxin 1A is important for calcium-regulated secretion from neuro-endocrine PC12 cells. These results indicate that the syntaxins are a family of receptors for intracellular transport vesicles and that each target membrane may be identified by a specific member of the syntaxin family.
Bennett
M K
MK
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University Medical Center, California 94305.
García-Arrarás
J E
JE
Elferink
L A
LA
Peterson
K
K
Fleming
A M
AM
Hazuka
C D
CD
Scheller
R H
RH
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000378:metabolism*; D015152:Blotting, Northern; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D004247:DNA / Q000235:genetics / Q000378:metabolism; D015723:Gene Library; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D016716:PC12 Cells; D011061:Poly A / Q000032:analysis / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000032:analysis / Q000378:metabolism; D012333:RNA, Messenger; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013572:Synaptic Vesicles / Q000378:metabolism*; D050827:Syntaxin 1; D014158:Transcription, Genetic; D014162:Transfection
D000954:Antigens, Surface; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C494213:Stx1a protein, rat; D050827:Syntaxin 1; D011061:Poly A; D012313:RNA; D004247:DNA