DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans.
In the present study, we tested 19 Caucasian and 28 Black American narcoleptics for the presence of the human leucocyte antigen (HLA) DQB1*0602 and DQA1*0102 (DQ1) genes using a specific polymerase chain reaction (PCR)-oligotyping technique. A similar technique was also used to identify DRB1*1501 and DRB1*1503 (DR2). Results indicate that all but one Caucasian patient (previously identified) were DRB1*1501 (DR2) and DQB1*0602/DQA1*102 (DQ1) positive. In Black Americans, however, DRB1*1501 (DR2) was a poor marker for narcolepsy. Only 75% of patients were DR2 positive, most of them being DRB1*1503, but not DRB1*1501 positive. DQB1*0602 was found in all but one Black narcoleptic patient. The clinical and polygraphic results for this patient were typical, thus confirming the existence of a rare, but genuine form of DQB1*0602 negative narcolepsy. These results demonstrate that DQB1*0602/DQA1*0102 is the best marker for narcolepsy across all ethnic groups.
Mignot
E
E
Stanford University, School of Medicine, Sleep Disorders Center, Palo Alto, California.
Lin
X
X
Arrigoni
J
J
Macaubas
C
C
Olive
F
F
Hallmayer
J
J
Underhill
P
P
Guilleminault
C
C
Dement
W C
WC
Grumet
F C
FC
D044383:Black People / Q000235:genetics*; D002375:Catalepsy / Q000235:genetics; D005190:Family; D006683:HLA-DQ Antigens / Q000097:blood / Q000235:genetics*; D006684:HLA-DR Antigens / Q000097:blood / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D009290:Narcolepsy / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012895:Sleep, REM; D014481:United States; D044465:White People / Q000235:genetics*; D001741:Black or African American
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens