Post-coital contraceptive efficacy of the seeds of Nigella sativa in rats.
Hexane extract of the seeds of Nigella sativa L. prevented pregnancy in Sprague-Dawley rats treated orally at 2 g/kg daily dose on days 1-10 post-coitum. Significant antifertility activity was also observed in its column fractions and subfractions. At contraceptive dose, the active hexane extract exhibited only mild uterotrophic activity comparable almost to 0.002 mg/kg dose of 17 varies; is directly proportional to-Ethinylestradiol, but was devoid of any estrogenicity in the immature rat bioassay.
Keshri
G
G
Division of Endocrinology and Medicinal Chemistry, Central Drug Research Institute, Lucknow.
Singh
M M
MM
Lakshmi
V
V
Kamboj
V P
VP
D000818:Animals; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006586:Hexanes / Q000737:chemistry; D010052:Ovariectomy; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D014626:Vaginal Smears
D003281:Contraceptives, Postcoital; D006586:Hexanes; D010936:Plant Extracts; C026385:n-hexane; D004997:Ethinyl Estradiol