title: Potential adjuvants for synthetic vaccines. I. Modulators of macrophage activation.
abstract: The synthesis and biological activities of several glycopeptidolipids derived from muramyl dipeptide (MDP) are described. In combination with gamma interferon (INF-gamma) MDP derivatives 3c and 3d carrying glycyrrhetinic acid as rigid beta-aglycone synergise the action of the lymphokine in the release of H2O2 by activated human macrophages, while MDP derivatives 3a and 6a carrying the more flexible diphytanyl glycerol beta-aglycone inhibit it.
authors.affiliation: F. Hoffmann-La Roche AG, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Solange
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000138:chemical synthesis / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects; D014614:Vaccines, Synthetic / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D014614:Vaccines, Synthetic; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D007371:Interferon-gamma