title: Synthesis of new immunosuppressive myriocin analogs, 2-epi-myriocin, 14-deoxomyriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins: their structure-activity relationships.
abstract: Eight new myriocin analogs, 2-epi-myriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, and a known myriocin derivative, 14-deoxomyriocin, were synthesized from 2-deoxy-D-glucose via common intermediates in previous myriocin and Z-myriocin syntheses. The immunosuppressive activities of new myriocin analogs and Z-myriocin on mouse allogeneic mixed lymphocyte reaction were examined, and, by comparing with those of myriocin and 14-deoxomyriocin, some structure-activity relationships have been found.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yokokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Okuno
authors.forename: N
authors.initials: N
authors.lastname: Yagi
authors.forename: N
authors.initials: N
authors.lastname: Murakami
mesh_terms: D000818:Animals; D003847:Deoxyglucose / Q000737:chemistry; D005229:Fatty Acids, Monounsaturated / Q000138:chemical synthesis / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D005229:Fatty Acids, Monounsaturated; D007166:Immunosuppressive Agents; D003847:Deoxyglucose; C001996:thermozymocidin