Spectral analysis of systolic blood pressure and heart rate after heart transplantation in children.
1. The aim of the study was to examine the short-term variability in blood pressure and heart rate in 19 children who had received heart transplants and in eight normal control children. 2. Blood pressure was determined by a finger arterial pressure device. We examined the power spectra for heart rate and systolic blood pressure in the supine and tilted positions. In addition, we studied the acute changes in blood pressure and heart rate during active standing. 3. In the transplanted children we could distinguish two groups (groups A and B) in whom heart rate variability differed, although in both it was greatly reduced compared with controls (group C). In group A there were no significant fluctuations in the mid-frequency range for heart rate. The gain of the relationship between systolic blood pressure and heart rate was very low and there were virtually no heart rate changes associated with passive tilting. 4. By contrast, in group B transplant patients the heart rate variability, as assessed by standard deviation, was about half that of normal controls. The power spectra attenuation was greater in the high-frequency than in the mid-frequency bands. On passive tilting the latter became enhanced, but not the high-frequency variability. On active standing the tachycardic response was about half that of controls. The findings suggest some reinnervation involving cardiac sympathetic fibres to a greater degree than the fast-responding vagal fibres. 5. In both groups A and B the drop in systolic blood pressure observed early in active standing was about 4-6 times as great as in controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Constant
I
I
Centre de Pharmacologie Clinique, CNRS URA 1482, Hôpital Necker-Enfants Malades, Paris, France.
Girard
A
A
Le Bidois
J
J
Villain
E
E
Laude
D
D
Elghozi
J L
JL
D001794:Blood Pressure / Q000502:physiology*; D002648:Child; D006321:Heart / Q000294:innervation; D006339:Heart Rate / Q000502:physiology*; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology; D011184:Postoperative Period; D011187:Posture / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted; D016683:Supine Position / Q000502:physiology; D013599:Systole / Q000502:physiology