title: Dinucleotide polymorphism at the DXS1178 locus is tightly linked to PGK1 at Xq13.
abstract: A polymorphic CA repeat (locus name DXS1178) was isolated from a 1-megabase YAC (OTCC) containing the OTC gene, located at Xp21.1. However, amplification in human-rodent hybrid cells and segregation analysis in three CEPH families mapped the DXS1178 locus at Xq13. The mapping ambiguity is apparently caused by the chimeric nature of the OTCC YAC clone.
authors.affiliation: Department of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA.
authors.forename: R
authors.initials: R
authors.lastname: Fujita
authors.forename: C
authors.initials: C
authors.lastname: Skolnick
authors.forename: A J
authors.initials: AJ
authors.lastname: Pakstis
authors.forename: T L
authors.initials: TL
authors.lastname: Yang-Feng
authors.forename: A
authors.initials: A
authors.lastname: Swaroop
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D017931:DNA Primers / Q000737:chemistry; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009954:Ornithine Carbamoyltransferase / Q000235:genetics; D010735:Phosphoglycerate Kinase / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012174:Retinitis Pigmentosa / Q000235:genetics; D014960:X Chromosome
chemical_list: D017931:DNA Primers; D009954:Ornithine Carbamoyltransferase; D010735:Phosphoglycerate Kinase