Anti-idiotypic mimicry of a neutralizing epitope on the glycoprotein B complex of human cytomegalovirus.
Experiments were carried out to investigate the ability of rabbit anti-idiotype antibodies (Ab2), directed against an anti-human cytomegalovirus monoclonal antibody (Ab1), to induce neutralizing antibodies specific for the immunodominant glycoprotein B viral complex. Mice immunized with Ab2 produced anti-Ab2 (Ab3) that was both antigen and idiotype specific with regard to Ab1. We conclude that the Ab2 antibodies mimicked a neutralizing epitope and acted as a network antigen for inducing a specific anti-human cytomegalovirus antibody response in this experimental system.
Tackaberry
E S
ES
National Laboratory for Immunology, Laboratory Centre for Disease Control, Ottawa, Ontario, Canada.
Hamel
J
J
Larose
Y
Y
Brodeur
B R
BR
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology*; D000939:Epitopes; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D051379:Mice; D009500:Neutralization Tests; D011817:Rabbits; D014759:Viral Envelope Proteins / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000956:Antigens, Viral; D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus