title: Normal plasma levels of IGF binding protein in Perthes' disease. Follow-up of previous report.
abstract: Plasma levels of insulin-like growth factor binding protein-3 (IGFBP-3) were measured in 55 children with Perthes' disease and 55 age- and sex-matched controls. IGFBP-3 values did not differ between the 2 groups and corresponded well to normal values found by others. The IGF I/IGFBP-3 ratio was reduced during the first 2 years of Perthes' disease. Our findings indicate that low levels of circulating IGF I in Perthes' disease, as we have reported previously, are caused neither by altered concentrations of the principal IGF-binding protein, IGFBP-3, nor by an underlying growth hormone deficiency.
authors.affiliation: Department of Orthopedics, Köln University, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Neidel
authors.forename: E
authors.initials: E
authors.lastname: Schönau
authors.forename: D
authors.initials: D
authors.lastname: Zander
authors.forename: J
authors.initials: J
authors.lastname: Rütt
authors.forename: M H
authors.initials: MH
authors.lastname: Hackenbroch
mesh_terms: D000293:Adolescent; D002352:Carrier Proteins / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D007873:Legg-Calve-Perthes Disease / Q000097:blood*; D008297:Male; D013002:Somatomedins / Q000032:analysis*
chemical_list: D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins