Potentiation of bleomycin antitumor effectiveness by electrotherapy.
Electrotherapy was investigated for its ability to increase the responsiveness of murine tumors to bleomycin treatment. Mice bearing fibrosarcoma were treated with 250 micrograms bleomycin and then with 0.6 mA direct current (DC) for 60 min. Antitumor effects of single treatments were moderate with bleomycin, but significant with electrotherapy. Combined treatment with bleomycin followed by electrotherapy was more effective than either treatment alone. Tumor growth delay of the animals after combined treatment was greater than the summation of tumor growth delays after single treatments. The results of our study indicate that bleomycin and electrotherapy treatments interact, with electrotherapy potentiating the effectiveness of bleomycin treatment.
Sersa
G
G
Department of Tumor Biology and Biotherapy, Institute of Oncology, Ljubljana, Slovenia.
Novaković
S
S
Miklavcic
D
D
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004599:Electric Stimulation Therapy; D005260:Female; D051379:Mice; D008805:Mice, Inbred A; D012513:Sarcoma, Experimental / Q000628:therapy*
D001761:Bleomycin