title: Splenic lymphoma with villous lymphocytes with CD5+, CD11c+ B-cell phenotype.
abstract: A 64-year-old male suffered from splenomegaly without lymphadenopathy. His WBC count on admission was 6.1 x 10(9)/l with 55% abnormal lymphocytes. No monoclonal gammopathy was detected. Abnormal cells shown in films usually had relatively abundant cytoplasm with serrated edges. Under phase-contrast microscopy, the cells displayed short, needle-like processes. The immunophenotype of peripheral blood mononuclear cells were CD19+, CD20+, CD11c+, FMC7+, CD5+, CD10-, CD25- and SIg+. The spleen histology showed a distinctive pattern of white pulp infiltration by abnormal lymphocytes with features of plasma cell differentiation. These findings were compatible with the features of splenic lymphoma with villous lymphocytes.
authors.affiliation: Department of Internal Medicine, Saiseikai Maebashi Hospital, Gunma, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miyawaki
authors.forename: T
authors.initials: T
authors.lastname: Machii
authors.forename: H
authors.initials: H
authors.lastname: Hirabayashi
authors.forename: T
authors.initials: T
authors.lastname: Sakura
authors.forename: H
authors.initials: H
authors.lastname: Shiozaki
authors.forename: K
authors.initials: K
authors.lastname: Yashiro
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: J
authors.initials: J
authors.lastname: Tsuchiya
authors.forename: K
authors.initials: K
authors.lastname: Kashiwabara
authors.forename: T
authors.initials: T
authors.lastname: Kitani
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D001402:B-Lymphocytes / Q000737:chemistry / Q000473:pathology*; D018845:CD11 Antigens; D018956:CD5 Antigens; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000175:diagnosis; D016393:Lymphoma, B-Cell / Q000145:classification / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000473:pathology*; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000145:classification / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013163:Splenomegaly / Q000209:etiology
chemical_list: D015703:Antigens, CD; D018845:CD11 Antigens; D018956:CD5 Antigens