[Study on efficacy of adult primary nephrotic syndrome with TCM-WM therapy and its hemorheologic effects].
The efficacy of TCM-WM therapy in treating adult primary nephrotic syndrome in comparing with using Western medicine alone and its influence on patient's hemorheology was investigated. The results showed that with the therapy of combined therapy the clinical remission rate and total effective rate were 65.4% and 88.5%, while that of Western medicine alone were 37.0% and 59.3% respectively. There was significant difference between the above-mentioned two groups (P < 0.01). Adverse effect scores with combined therapy were much lower than that of WM alone (P < 0.01). The recurrence rate of the illness with TCM-WM and WM therapy were 7.25% and 53.13% respectively (P < 0.01). Furthermore, the combined treatment of TCM-WM could remarkably improve the blood viscosity and reduce the content of fibrinogen. It was suggested that Syndrome Differentiation with the administration of steroid could not only ameliorate the adverse effects of steroid but promote the efficacy and reduce the recurrence of the disease. Besides, the addition of blood-activating and stasis-removing herbs could also improve the blood viscosity and the impaired fibrinolysis.
Liu
B H
BH
Dept. of TCM, Second Affiliated Hospital, Lanzhou Medical College.
Dai
E L
EL
Cao
T M
TM
D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D009404:Nephrotic Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage*
D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide; D005340:Fibrinogen; D011241:Prednisone