title: Rapid gas chromatographic assay of diazinon: application to the study of diazinon kinetics in rats.
abstract: A rapid method was developed for the determination of diazinon in plasma using gas chromatography with electron-capture detection (GC-ECD). Following a single extraction with hexane from 100 microliters of plasma, diazinon was quantitated on a 3% OV-17 column. The detection limit was 10 ng/ml and linearity was obtained in the range of 25 ng/ml-2500 ng/ml. The applicability of the assay to single-dose kinetics in rats is illustrated.
authors.affiliation: Poisons Centre, INSERM U80, Alexis Carrel Faculty of Medicine, Lyon, France.
authors.forename: H X
authors.initials: HX
authors.lastname: Wu
authors.forename: C
authors.initials: C
authors.lastname: Evreux-Gros
authors.forename: J
authors.initials: J
authors.lastname: Descotes
mesh_terms: D000818:Animals; D002849:Chromatography, Gas / Q000379:methods*; D003976:Diazinon / Q000097:blood* / Q000493:pharmacokinetics; D004583:Electrons; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results
chemical_list: D003976:Diazinon