Marine natural products. XXXIV. Trisindoline, a new antibiotic indole trimer, produced by a bacterium of Vibrio sp. separated from the marine sponge Hyrtios altum.
A new antibiotic indole trimer named trisindoline (1) was isolated, together with a known dioxopiperazine brevianamide F (2), from the culture of a bacterium of Vibrio sp., which was separated from the Okinawan marine sponge Hyrtios altum. The structure of trisindoline (1) has been determined on the bases of physicochemical evidence and chemical synthesis.
Kobayashi
M
M
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Aoki
S
S
Gato
K
K
Matsunami
K
K
Kurosu
M
M
Kitagawa
I
I
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000382:microbiology*; D014733:Vibrio / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D007211:Indoles; C092639:trisindoline