[AIDS in Denmark. 2. Survival after the diagnosis of AIDS. Danish Study Group for HIV infection].
The survival pattern was studied for 687 Danish AIDS patients (93% of notified cases in the study period) who were diagnosed with AIDS during the period from 1980 to 1990. The median survival was 17 months. Factors significantly associated with a shortened survival were transfusion-acquired HIV infection, age > 40 years, year of diagnosis before 1987, and the presence of either disseminated infection with Mycobacterium avium-complex, Cytomegalovirus chorioretinitis or malignant lymphoma at time of the AIDS diagnosis. There was also a significant association between survival and CD4 cell count at time of AIDS diagnosis. Patients who had CD4 cell counts above 200 x 10(6)/l had twice as long a survival as patients who had CD4 cell counts less than 50 x 10(6)/l. The prognosis of Danish AIDS patients remains poor. The most important determinant of survival time appears to be the degree of immune deficiency at time of diagnosis.
Lundgren
J D
JD
Infektionsmedicinsk afdeling, Hvidovre Hospital, København.
Pedersen
C
C
Bentsen
K D
KD
Gerstoft
J
J
Seefeldt-Nielsen
T
T
Nielsen
T L
TL
Jensen
G F
GF
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000276:immunology / Q000401:mortality*; D000328:Adult; D000367:Age Factors; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003718:Denmark / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000401:mortality; D006801:Humans; D008297:Male; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors