title: [Prospective assessment of combined treatment with high doses of intravenous methylprednisolone and long term administration of Isoprinosine in multiple sclerosis patients].
abstract: The authors present a prospective assessment of combined treatment with high doses of methylprednisolone intravenously and long term administration (12-18 months) of Isoprinosine. The study included 57 patients with clinically certain diagnosis of multiple sclerosis who were examined 1-5 years after treatment completion. Patients with similar degree of motor function disability served for control. Clinical improvement assessed by the motor disability scale of Kurtzke was obtained in over half the patients with various forms of the disease. The results were best in cases of multiple sclerosis of remittent course and those treated at the beginning of the disease.
authors.affiliation: Klinicznego Oddziału Neurologicznego 10 Wojskowego Szpitala Klinicznego z Poliklinika, Bydgoszczy.
authors.forename: Z
authors.initials: Z
authors.lastname: Maciejek
authors.forename: A
authors.initials: A
authors.lastname: Niezgodzińska-Maciejek
mesh_terms: D000328:Adult; D004306:Dose-Response Relationship, Immunologic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid / Q000276:immunology; D007275:Injections, Intravenous; D007542:Inosine Pranobex / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D011446:Prospective Studies
chemical_list: D007074:Immunoglobulin G; D007542:Inosine Pranobex; D008775:Methylprednisolone