[Evaluation of various experimental dyslipoproteinemia models in the study of hypolipidemic agents].
Models of experimental dyslipoproteinemias have been developed by using non-inbred rats (males and females) and guinea-pigs. Administration of cholesterol (C) with fats and supplementation of 4-hydroxy-6-methyl-2-thiouracil to male rats and that of C in the mixture of fats to guinea-pigs have been demonstrated to lead to the development of atherogenic dyslipoproteinemias. Genfibrozil, cholestyramine and vasosan II, a new pectin-enriched formulation, promoted normalization of the impaired serum lipoprotein spectrum caused by exogenous C administration. Bilateral ovariectomy in female rats induced atherogenic dyslipoproteinemia. The use of the estrogen derivative methyl ether of 6-oxa-D-homo-8-isoestrone normalized lipid and lipoprotein metabolic disturbances.
Ryzhenkov
V E
VE
Chistiakova
A M
AM
Frolova
Iu V
IuV
Lozovskiĭ
V T
VT
Kameneva
I Iu
IIu
Vasil'eva
L E
LE
D000818:Animals; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005260:Female; D006168:Guinea Pigs; D006951:Hyperlipoproteinemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D051381:Rats
D000960:Hypolipidemic Agents