title: The protein import receptor of mitochondria.
abstract: Protein import into the mitochondria of Saccharomyces cerevisiae depends on two receptor subcomplexes composed of integral outer-membrane proteins. One subcomplex is the MAS37-MAS70 heterodimer, which preferentially recognizes the mature regions of precursor proteins associated with ATP-dependent cytosolic chaperones. The other subcomplex contains the acidic proteins MAS20 and MAS22, which recognize the positively charged targeting sequences of a wide variety of mitochondrial precursors. We propose that the two subcomplexes can act together as a single, multifunctional receptor that binds simultaneously to different regions of a precursor molecule.
authors.affiliation: Biozentrum, University of Basel, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Lithgow
authors.forename: B S
authors.initials: BS
authors.lastname: Glick
authors.forename: G
authors.initials: G
authors.lastname: Schatz
mesh_terms: D001692:Biological Transport; D018833:Chaperonins / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004734:Energy Metabolism; D008928:Mitochondria / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D011506:Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D018833:Chaperonins