Signal transduction mechanisms in mesenchymal cells.
Mesenchymal cells are continually stimulated by a wide spectrum of biological mediators. These mediators bind to receptors on the cell surface and initiate a cascade of signaling events. The initial signal transduction pathways known to be stimulated in mesenchymal cells included phospholipase C, phospholipase D, phospholipase A2, adenylate cyclase, receptor tyrosine kinases, and receptor serine/threonine kinases. These pathways are reviewed and specific applications for therapeutic intervention in wound healing and regenerative therapy in the periodontium are discussed.
McAllister
B S
BS
Department of Periodontology, Oregon Health Sciences University, Portland 97201-3097.
Walters
J D
JD
Olson
M S
MS
D000262:Adenylyl Cyclases / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D010519:Periodontium / Q000502:physiology; D010739:Phospholipase D / Q000502:physiology; D010741:Phospholipases A / Q000502:physiology; D054467:Phospholipases A2; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D010741:Phospholipases A; D054467:Phospholipases A2; D010738:Type C Phospholipases; D010739:Phospholipase D; D000262:Adenylyl Cyclases