Effects of monoaminergic agonists on alcohol-induced increases in mouse aggression.
Two sets of studies were conducted on alcohol-induced increases in aggression. In the first, the effects of alcohol on target biting and resident-intruder attack were assessed in mice fed a standard diet or one supplemented with 0.5% L-tryptophan. Mice attacked an inanimate target at a high rate following tail shock, an intermediate rate during the intershock interval and a low rate during a tone that preceded the shock. Alcohol increased target biting following shock and during the intershock interval, an effect partially blocked by tryptophan. Resident mice attacked intruders 27.2 +/- 5.3 times per 10-minute session with an average latency of 155 +/- 42 seconds. Alcohol increased the number of attacks and lowered the latency to the first attack. Again, tryptophan partially blocked these effects. Finally, in a second set of mice, the same tryptophan diet was found to potentiate the aggression-reducing effects of fluoxetine and fenfluramine without disrupting motor performance. In the second study, the effects of alcohol administered alone or in combination with tyramine were assessed in the resident-intruder paradigm. Again, it was observed that low doses of alcohol increased the resident attack of intruders. Although this effect was heightened by the co-administration of tyramine, the effect failed to reach statistical significance. These observations are discussed in reference to alcohol-induced increases in offensive and defensive aggression and the possible modulation of this effect by brain monoamines.
Wagner
G C
GC
Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903.
Fisher
H
H
Pole
N
N
Borve
T
T
Johnson
S K
SK
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D005277:Fenfluramine / Q000378:metabolism; D005473:Fluoxetine / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000032:analysis / Q000378:metabolism; D008297:Male; D051379:Mice; D014364:Tryptophan / Q000378:metabolism*
D005473:Fluoxetine; D005277:Fenfluramine; D000431:Ethanol; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan