The voltage-gated non-selective cation channel from human red cells is sensitive to acetylcholine.
Using patch-clamp technique it is demonstrated, that the voltage-gated non-selective cation channel present in the human red cell is coupled to an acetylcholine receptor of nicotinic type. The concentration dependence of carbachol, the potency of selected agonists and an estimate of the numbers of channels/red cell are reported.
Bennekou
P
P
August Krogh Institute, University of Copenhagen, Denmark.
D000109:Acetylcholine / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism
D007473:Ion Channels; D011978:Receptors, Nicotinic; D002217:Carbachol; D000109:Acetylcholine