[Lysosomal system in hormonal mechanisms. Review].
The role of lysosomes in the intracellular mechanism of action of several steroid an proteic hormones has been demonstrated. In presence of the specific hormone the target cell induce membranal changes and the lysosomes are moved toward the nucleus; after this the lysosomal enzymes are released in the perinuclear space. For the moment it is not possible to know the biochemical role of this enzymatic activities upon the nucleic acids function and des-repretion process of specific genes, but the inhibition of lysosomes movement utilizing hormone antagonist or dexamethasone inhibits some reproductive process like the implantation of the mammalian egg. We present herein a review related with the mode action of some hormones through the lysosomes in reproductive processes.
Duran Reyes
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Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Instituto Mexicano del Seguro Social.
González Macías
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Hicks
J J
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D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D010064:Embryo Implantation; D004967:Estrogens / Q000502:physiology; D005260:Female; D006062:Gonadotropins / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D066298:In Vitro Techniques; D008247:Lysosomes / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D010053:Ovary / Q000502:physiology; D010907:Pituitary Hormones / Q000502:physiology; D011247:Pregnancy; D011388:Prolactin / Q000502:physiology; D051381:Rats; D012098:Reproduction; D014178:Translocation, Genetic; D014599:Uterus / Q000502:physiology; D014667:Vasopressins / Q000502:physiology
D004967:Estrogens; D006062:Gonadotropins; D006728:Hormones; D010907:Pituitary Hormones; D014667:Vasopressins; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D000242:Cyclic AMP; D006867:Hydrolases