Bitetrahydroanthracenes from flowers of Cassia torosa Cav.
A new bitetrahydroanthracene derivative, torosaol-III, was isolated from the flowers of Cassia torosa Cav. along with physcion, 5,7'-physcionanthrone-physcion, 5,7'-biphyscion, torosanin-9,10-quinone, 5,7-dihydroxy-chromone, naringenin, and chrysoeriol. The structure of torosaol-III was established as 3,3'-4,4'-tetrahydro-3,3'8,8'9,9'-hexahydroxy-6,6'-dimethoxy-3,3'- dimethyl-1(2H),1'(2H)-5,7'-bianthracenone on the basis of spectral and chemical evidence. Dimeric tetrahydroanthracenes exhibited cytotoxic activity against KB cells in the tissue culture.
Kitanaka
S
S
College of Pharmacy, Nihon University, Chiba, Japan.
Takido
M
M
D000873:Anthracenes / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002366:Cassia / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal
D000873:Anthracenes; D000970:Antineoplastic Agents