title: Localization of the human HER4/erbB-4 gene to chromosome 2.
abstract: The HER4/erbB-4 gene has been isolated as the fourth member of the human EGFR subfamily of tyrosine kinases and has been reported to encode a receptor for NDF/heregulin. In the present study we determined the chromosomal location of the HER4/erbB-4 gene within the human genome. Using human cDNA probes in fluorescence in situ hybridization (FISH), we mapped the HER4/erbB-4 gene to human chromosome 2q33.3-34. This finding established that also the HER4/erbB-4 gene is located in close vicinity of homeobox and collagen gene loci, as is the case for the related EGFR, erbB-2/neu and erbB-3. Aberrations of this chromosomal region associated with T cell leukemias and lymphomas as well as alveolar rhabdomyosarcomas raise the possibility that HER4/erbB-4 might be activated in these tumour types.
authors.affiliation: Laboratory of Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: D B
authors.initials: DB
authors.lastname: Zimonjic
authors.forename: M
authors.initials: M
authors.lastname: Alimandi
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: N C
authors.initials: NC
authors.lastname: Popescu
authors.forename: M H
authors.initials: MH
authors.lastname: Kraus
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D018076:DNA, Complementary; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D066247:Receptor, ErbB-4
chemical_list: D018076:DNA, Complementary; C587689:ERBB4 protein, human; D066246:ErbB Receptors; D066247:Receptor, ErbB-4