Myeloid depression follows infection of susceptible newborn mice with the parvovirus minute virus of mice (strain i).
The in vivo myelosuppressive capacity of strain i of the parovirus minute virus of mice (MVMi) was investigated in newborn BALB/c mice inoculated with a lethal intranasal dose. MVMi infection reached maximum levels of DNA synthesis and infectious titers in lymphohemopoietic organs at 4 to 6 days postinoculation and was restricted by an early neutralizing humoral immune response. After viral control (by 10 days postinoculation), a significant decrease in femoral and splenic cellularity, as well as in granulocyte-macrophage colony-forming unit and erythroid burst-forming unit hemopoietic progenitors, was observed in most inoculated animals. This delayed myeloid depression, although it may be not a major cause of the lethality of the infection, implies indirect pathogenic mechanisms induced by MVMi infection in a susceptible host.
Segovia
J C
JC
Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Bueren
J A
JA
Almendral
J M
JM
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000096:biosynthesis; D001855:Bone Marrow Diseases / Q000209:etiology* / Q000276:immunology / Q000821:virology; D006410:Hematopoiesis; D006413:Hematopoietic System / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008915:Minute Virus of Mice / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D010322:Parvoviridae Infections / Q000209:etiology* / Q000276:immunology / Q000821:virology; D013997:Time Factors; D014779:Virus Replication
D000914:Antibodies, Viral