[Study on the peptides of serum and gastric juice in patients with gastric cancer].
This investigation, conducted on 35 patients with advanced-stage gastric cancer, included 28 men and 7 women with a mean age of 50.1 years; also studied were 33 normal subjects as controls: 26 men and 7 women with a mean age of 45.8 years. Samples of blood and gastric juice were collected at fasting and in gastroscopy respectively. Substance P (SP), beta-endorphin (beta-EP), vasoactive intestinal peptide (VIP), motilin (MTL), gastrin (GT), and leu-enkephalin (LEK) of the sera and gastric juices were measured by radioimmunoassay kits. In the patients, SP and beta-EP of serum and gastric juice, and VIP, MTL and LEK of gastric juice, were higher than in the normal subjects (p < 0.01); gastrin of serum and gastric juice were decreased (p < 0.01). Serum and gastric juice SP, beta-EP levels correlated negatively with the gastrin (r = 0.462-0.519, p < 0.05). These data support the assumption that study of the peptides of serum and gastric juice can show a clinically significant change in gastric cancer patients.
Xu
C T
CT
Department of Gastroenterology, Air Force Hospital, Lanzhou.
Pan
B R
BR
Wang
Y M
YM
D000328:Adult; D000368:Aged; D004723:Endorphins / Q000032:analysis; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000032:analysis; D009479:Neuropeptides / Q000032:analysis*; D013274:Stomach Neoplasms / Q000378:metabolism*; D013373:Substance P / Q000032:analysis; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
D004723:Endorphins; D009479:Neuropeptides; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D009037:Motilin