Antiandrogen. II. Oxygenated 2-oxapregnane steroids.
Oxygenated derivatives of 2-oxachlormadinone acetate (17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) at C11, C15, and C16 were prepared as potential antiandrogenic agents. Biological evaluation showed the 15 beta-hydroxyl compound to have a high potent antiandrogenic activity when tested in the castrated male rat.
Takegawa
S
S
Research Department of Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
Koizumi
N
N
Takahashi
H
H
Shibata
K
K
D000726:Androgen Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002715:Chlormadinone Acetate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000187:drug effects
D000726:Androgen Antagonists; D002715:Chlormadinone Acetate; C069297:osaterone acetate