title: Combined cardioplegia delivery offers no advantage over antegrade cardioplegia administration in coronary surgical patients with a preserved left ventricular function.
abstract: The effects of antegrade and of combined antegrade and retrograde cardioplegia were compared in 101 patients undergoing elective coronary artery surgery. The patients were randomly allocated to two groups: antegrade cardioplegia was administered in 53 patients and combined cardioplegia in 43 patients. The patients of the two groups were similar in age, sex and left ventricular ejection fraction. Aortic clamping time and the number of coronary bypasses were equal in the groups. The ventricular septal temperature was measured continuously during cardioplegia administration, after each distal anastomosis accomplished, and continuously after aortic declamping. Serum CK-MB activities were serially measured for up to 3 days postoperatively. Electrocardiograms (ECG) were taken preoperatively, as well as on the first, second and eighth postoperative days. The left ventricular function was evaluated with a volume load test preoperatively and on the first postoperative morning. The two groups were similar with respect to myocardial cooling, response to volume loading, the number of patients with perioperative myocardial infarctions, cardiac arrhythmias or atrioventricular conduction blocks and clinical outcome. However, the CK-MB activities were lower in the antegrade group suggesting better myocardial protection in an unselected group of patients undergoing coronary artery bypass grafting.
authors.affiliation: Department of Surgery, University of Turku, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Savunen
authors.forename: K
authors.initials: K
authors.lastname: Kuttila
authors.forename: A
authors.initials: A
authors.lastname: Rajalin
authors.forename: M
authors.initials: M
authors.lastname: Inberg
authors.forename: J
authors.initials: J
authors.lastname: Niinikoski
authors.forename: J
authors.initials: J
authors.lastname: Jalonen
authors.forename: J
authors.initials: J
authors.lastname: Perttilä
authors.forename: M
authors.initials: M
authors.lastname: Valtonen
authors.forename: E
authors.initials: E
authors.lastname: Engblom
authors.forename: O
authors.initials: O
authors.lastname: Peltola
mesh_terms: D000704:Analysis of Variance; D001026:Coronary Artery Bypass / Q000379:methods*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D017202:Myocardial Ischemia / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control; D013696:Temperature; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase