title: [Local injection of peplomycin adsorbed on activated carbon particles combined with 60Co radiation against inoperable advanced esophageal cancer--two long-term survivors].
abstract: We have developed a new dosage form, PEP-CH, consisting of peplomycin adsorbed onto small activated carbon particles. Ten patients with inoperable advanced esophageal cancer were treated with endoscopic local injection of PEP-CH combined with radiation using 60Co. Two of 5 patients who completed the treatment have survived over one year (19 and 23 months) now.
authors.affiliation: First Dept. of Surgery, Kyoto Prefectural University of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Oyama
authors.forename: T
authors.initials: T
authors.lastname: Sakakibara
authors.forename: K
authors.initials: K
authors.lastname: Ozaki
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: S
authors.initials: S
authors.lastname: Sasaki
authors.forename: C
authors.initials: C
authors.lastname: Sakakura
authors.forename: M
authors.initials: M
authors.lastname: Shimotsuma
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: O
authors.initials: O
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D002244:Carbon; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017663:Peplomycin; D011379:Prognosis
chemical_list: D000903:Antibiotics, Antineoplastic; D003037:Cobalt Radioisotopes; D003692:Delayed-Action Preparations; D001761:Bleomycin; D017663:Peplomycin; D002244:Carbon