title: Mutagenic activity of phosmet, the active component of the organophosphorus insecticide Decemtione EK 20 in Salmonella and Saccharomyces assays.
abstract: Phosmet, the active component of the organophosphorus insecticide Decemtione EK 20, was shown to be mutagenic in the standard Ames Salmonella/mammalian microsome assay in the absence and presence of metabolic activation. It appears to be a direct mutagen inducing base substitution mutations (TA100) as well as a weak frameshift mutagen (TA97). This compound was genotoxic in the Saccharomyces cerevisiae D7 strain. It significantly increased reverse mutation, mitotic crossing-over and slightly, but not significantly, increased gene conversion at the highest concentration used.
authors.affiliation: Department of Genetics, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
authors.forename: V
authors.initials: V
authors.lastname: Vlcková
authors.forename: E
authors.initials: E
authors.lastname: Miadoková
authors.forename: S
authors.initials: S
authors.lastname: Podstavková
authors.forename: D
authors.initials: D
authors.lastname: Vlcek
mesh_terms: D000818:Animals; D001711:Biotransformation; D016368:Frameshift Mutation; D007306:Insecticides / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity*; D010706:Phosmet / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D007306:Insecticides; D009153:Mutagens; D010706:Phosmet