title: [Isoprinosine therapy in chronic hepatitis C (multicenter placebo-controlled double-blind prospective study)].
abstract: A placebo controlled clinical trial. Thirty two patients with chronic C hepatitis have been enrolled in a double blinded study to assess the therapeutic effect on an orally given antiviral-immunomodulatory drug, Isoprinosine. Seventeen patients were given Isoprinosine (3 g/day) and fifteen were on placebo. The treatment has been lasted for four months, when patients examined monthly. Clinical signs, liver function tests and side effects were evaluated. At the end of the trial, side effects and elevated serum alanine aminotransferase (ALT/GPT) levels occurred with higher frequency in Isoprinosine-treated patients. The results show that this antiviral drug has no beneficial effect in chronic C hepatitis.
authors.affiliation: Pésci Orvostudományi Egyetem I. Belgyógyászati Klinika, Pécs.
authors.forename: A
authors.initials: A
authors.lastname: Pár
authors.forename: T
authors.initials: T
authors.lastname: Beró
authors.forename: G
authors.initials: G
authors.lastname: Brasch
authors.forename: A
authors.initials: A
authors.lastname: Gógl
authors.forename: G
authors.initials: G
authors.lastname: Kamarás
authors.forename: E
authors.initials: E
authors.lastname: Méhesfalvi
authors.forename: Z
authors.initials: Z
authors.lastname: Ozsvár
authors.forename: M
authors.initials: M
authors.lastname: Paál
authors.forename: I
authors.initials: I
authors.lastname: Szipöcs
authors.forename: L
authors.initials: L
authors.lastname: Telegdy
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006526:Hepatitis C / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D007542:Inosine Pranobex / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies
chemical_list: D010919:Placebos; D000410:Alanine Transaminase; D007542:Inosine Pranobex