title: Chronotoxicity of glufosinate ammonium in mice.
abstract: The effect of a circadian-stage dependent dosing schedule on the toxicity of glufosinate was studied in mice. Male ICR mice were housed in a standardized 12:12 light:dark cycle for 3 w. Each animal was given 1500 or 3000 mg glufosinate/kg po. A highly significant circadian rhythm occurred in the resulting mortality, with the highest mortality from doses given during the light phase and the lowest from doses administered during the dark phase. The circadian-stage dependent dosing schedule had a marked influence on the pattern of acute glufosinate toxicity in mice.
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshiyama
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: R
authors.initials: R
authors.lastname: Kondo
authors.forename: F
authors.initials: F
authors.lastname: Tomonaga
authors.forename: T
authors.initials: T
authors.lastname: Ohwada
mesh_terms: D000613:Aminobutyrates / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D000613:Aminobutyrates; D006540:Herbicides; C003121:phosphinothricin