title: Incidence of paratuberculosis after vaccination against M. paratuberculosis in two infected dairy herds.
abstract: Vaccination against paratuberculosis of all newborn animals has been performed since April 1984 in two dairy herds with a high incidence of clinical cases of paratuberculosis, using a vaccine containing heat-inactivated M. paratuberculosis in a water/mineral oil emulsion. Animals slaughtered between April 1984 and January 1991 were included in the study. Histology, bacterioscopy and culture on Smith and modified Löwenstein-Jensen media were performed using jejunum, ileum and draining lymph nodes. The animals present on the farm in April 1984 constituted a retrospective non-vaccinated group, giving an indication of the initial infection rate. After vaccination, the percentage of animals culled for clinical paratuberculosis decreased significantly (7.8 to 1.8%; P < 0.005), as did the percentage of animals with positive histology (11.8% to 5%). The incidence of infected animals, defined by positive results in histology and or bacterioscopy and/or culture, however, increased from 21.8% to 25.9%.
authors.affiliation: Department of Large Animal Medicine and Nutrition, State University Utrecht, The Netherlands.
authors.forename: G H
authors.initials: GH
authors.lastname: Wentink
authors.forename: J H
authors.initials: JH
authors.lastname: Bongers
authors.forename: A A
authors.initials: AA
authors.lastname: Zeeuwen
authors.forename: F H
authors.initials: FH
authors.lastname: Jaartsveld
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D015994:Incidence; D016927:Mycobacterium avium subsp. paratuberculosis / Q000276:immunology*; D009426:Netherlands / Q000453:epidemiology; D010283:Paratuberculosis / Q000453:epidemiology / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary*; D015164:Vaccines, Inactivated
chemical_list: D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated