[Risk factor: diabetes mellitus].
The prevalence of diabetic microangiopathy (retinopathy, microalbuminuria, and neuropathy) and macroangiopathy (ischemic changes in EKG) in patients with diabetes mellitus was compared between patients newly found on occasion of mass-screening without any symptoms and signs in Funagata, Japan, and patients who visited the outpatient clinic of our university hospital. The mean fasting blood glucose level in the Funagata group was lower, and the mean duration of diabetes was shorter. The prevalence of every microangiopathic complication was significantly lower in the Funagata group than in the outpatient clinic group. However, the prevalence of ischemic changes in EKG was not different between the two groups. The conclusion that prevalence of diabetic microangiopathic complications was primarily related to the degree and duration of hyperglycemia seemed to be in accordance with the results of the Diabetes Control and Complications Trial (DCCT). The role of hyperglycemia for pathogenesis of macroangiopathy and atherosclerosis has been controversial. Not only hyperglycemia but also hypertension, dyslipoproteinemia, and other factors due to insulin resistance resulting from visceral fat syndrome, might be responsible for the occurrence of atherosclerosis.
Tominaga
M
M
3rd Department of Internal Medicine, Yamagata University School of Medicine.
D001161:Arteriosclerosis / Q000209:etiology*; D003925:Diabetic Angiopathies / Q000150:complications*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012307:Risk Factors