Delayed appearance of anti-myelin-associated glycoprotein antibodies in a patient with chronic demyelinating polyneuropathy.
A patient who had a polyneuropathy compatible with a chronic inflammatory demyelinating polyneuropathy and was initially negative for anti-myelin-associated glycoprotein (MAG) antibodies developed a double monoclonal gammopathy, IgM kappa and IgM lambda, two years after the diagnosis. The IgM kappa, but not the IgM lambda, exhibited strong anti-MAG antibody activity. The late appearance of the anti-MAG immunoreactivity suggests that in patients with an initial diagnosis of chronic inflammatory demyelinating polyneuropathy, the search for anti-MAG antibodies should be repeated during the course of the neuropathy.
Valldeoriola
F
F
Service of Neurology, Hospital Clínic i Provincial de Barcelona, Spain.
Graus
F
F
Steck
A J
AJ
Muñoz
E
E
de la Fuente
M
M
Gallart
T
T
Ribalta
T
T
Bombí
J A
JA
Tolosa
E
E
D001323:Autoantibodies / Q000097:blood*; D003711:Demyelinating Diseases / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005385:Fingers / Q000294:innervation; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D010265:Paraproteinemias / Q000097:blood / Q000150:complications / Q000276:immunology*; D010292:Paresthesia / Q000097:blood / Q000276:immunology* / Q000503:physiopathology
D001323:Autoantibodies; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein