Oral squamous cell carcinoma arising in phenytoin-induced hyperplasia.
A case is described of a squamous cell carcinoma arising in an area of phenytoin-induced gingival hyperplasia. Recent literature concerning the effects of phenytoin on the gingival tissues cites a possible mechanism of phenytoin-induced carcinogenesis.
McLoughlin
P
P
Department of Oral & Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead, West Sussex.
Newman
L
L
Brown
A
A
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology / Q000556:secondary; D017809:Fatal Outcome; D005885:Gingival Hyperplasia / Q000139:chemically induced / Q000150:complications*; D005887:Gingival Neoplasms / Q000209:etiology / Q000473:pathology; D006801:Humans; D007573:Jaw Neoplasms / Q000209:etiology / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009062:Mouth Neoplasms / Q000209:etiology* / Q000473:pathology / Q000556:secondary; D010157:Palatal Neoplasms / Q000209:etiology / Q000556:secondary; D010672:Phenytoin / Q000009:adverse effects*
D010672:Phenytoin