Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system.
We have identified, by affinity chromatography, a binding protein for the snake venom toxin taipoxin. The sequence of this 47 kDa protein is unique, is characteristic of a secreted protein, and has homology to the acute phase proteins serum amyloid P protein and C-reactive protein of the pentraxin family. We have named this protein neuronal pentraxin (NP), as Northern analysis and in situ hybridization demonstrate high message levels in neurons of cerebellum, hippocampus, and cerebral cortex. Because NP may be released synaptically and has homology to immune proteins potentially involved in uptake of lipidic, toxic, or other antigenic material, we suggest that NP may be involved in a general uptake of synaptic macromolecules.
Schlimgen
A K
AK
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Helms
J A
JA
Vogel
H
H
Perin
M S
MS
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D002097:C-Reactive Protein / Q000032:analysis / Q000096:biosynthesis* / Q000737:chemistry*; D002531:Cerebellum / Q000378:metabolism; D002846:Chromatography, Affinity; D003001:Cloning, Molecular; D004546:Elapid Venoms / Q000378:metabolism / Q000633:toxicity; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis* / Q000737:chemistry; D009457:Neuroglia / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009928:Organ Specificity; D010446:Peptide Fragments / Q000737:chemistry / Q000302:isolation & purification; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D000683:Serum Amyloid P-Component / Q000737:chemistry*; D000099153:Pentraxins
D002097:C-Reactive Protein; D004546:Elapid Venoms; D009419:Nerve Tissue Proteins; D009466:Neuromuscular Blocking Agents; D010446:Peptide Fragments; D012333:RNA, Messenger; D011994:Recombinant Proteins; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C015523:taipoxin