title: [Local forms of amyloidosis as a manifestation of age-related pathology: a new look at the problem].
abstract: Endocrine (isolated atrium amyloidosis and insular amyloidosis of the pancreas) and non-endocrine (aorta, eye, prostate and/or seminal vesicles, cerebral amyloidosis) forms should be distinguished among senile local amyloidosis. Senile polyorgan amyloidosis is also possible: combination of endocrine forms with aorta amyloidosis or that of insular amyloidosis with cerebral and eye amyloidosis. These data reject Schwartz tetrad as an obligatory manifestation of an old age. Peptide hormones, serum and specialized proteins are precursors of amyloid fibrillary protein; each of them is able to beta-cross-conformation and formation of the fibrillar amyloid protein. This implies that conformational protein disturbances in increasing senile tissue bradytrophia and extinction of the diffuse endocrine system function are a basis of amyloidogenesis in senile local amyloidosis. Clinical manifestations of senile amyloidosis are very variable, but local senile amyloidosis is not recognized clinically. Its diagnosis will probably become possible with clinical use of molecular biology achievements and, first of all, those of molecular genetics.
authors.forename: V V
authors.initials: VV
authors.lastname: Serov
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000378:metabolism / Q000473:pathology*; D001018:Aortic Diseases / Q000378:metabolism / Q000473:pathology; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology; D009202:Cardiomyopathies / Q000378:metabolism / Q000473:pathology; D004700:Endocrine System Diseases / Q000378:metabolism / Q000473:pathology*; D005128:Eye Diseases / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000378:metabolism / Q000473:pathology
chemical_list: D000682:Amyloid