Antimutagenicity of cyclohexanol towards 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone and N-nitrosodiethylamine in Salmonella typhimurium strain TA100.
The ability of cyclohexanol to inhibit the mutagenicity of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and of N-nitrosodiethylamine (NDEA) was tested on Salmonella typhimurium strain TA100. Cyclohexanol produced a dose-dependent decrease in the number of revertants induced by a single dose of NNK (24 mumoles) or NDEA (59 mumoles). Nevertheless, this inhibitory effect was not observed with other premutagenic agents such as benzo[a]pyrene and 2-aminoanthracene nor with direct mutagens such as ethyl methanesulfonate and methyl methanesulfonate. These results suggest that cyclohexanol interferes with the 'bioactivation' of the tested nitrosamines in a similar way that other alcohols such as ethanol or isopropanol interfere with N-nitro-sodimethylamine and NDEA metabolism.
Espinosa-Aguirre
J J
JJ
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, D.F.
Vilchis
C
C
Ostrosky-Wegman
P
P
Benitez
L
L
Lares
I
I
Rubio
J
J
D016587:Antimutagenic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D003511:Cyclohexanols / Q000493:pharmacokinetics / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D008110:Liver Extracts / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D013489:Suppression, Genetic
D016587:Antimutagenic Agents; D003511:Cyclohexanols; D065607:Cytochrome P-450 Enzyme Inhibitors; D008110:Liver Extracts; D009153:Mutagens; D009602:Nitrosamines; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D003577:Cytochrome P-450 Enzyme System; C008655:N'-nitrosonornicotine