title: Pathogenicity of influenza A/Seal/Mass/1/80 virus mutants for mammalian species.
abstract: Increases in infectiousness, neurotropism and virulence were found in a laboratory variant of influenza A/Seal/Massachussets/1/80 (H7N7) virus having a highly cleavable hemagglutinin. Sequential passage from host to host further increased pathogenicity of the H7N7 virus in mice, ferrets and rats.
authors.affiliation: Institut für Virologie, Justus-Liebig-Universität, Giessen, Federal Republic of Germany.
authors.forename: H
authors.initials: H
authors.lastname: Scheiblauer
authors.forename: A P
authors.initials: AP
authors.lastname: Kendal
authors.forename: R
authors.initials: R
authors.lastname: Rott
mesh_terms: D000818:Animals; D001921:Brain / Q000821:virology*; D005260:Female; D005289:Ferrets; D006389:Hemagglutinins, Viral / Q000235:genetics / Q000378:metabolism; D009980:Influenza A virus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D008168:Lung / Q000821:virology; D051379:Mice; D009154:Mutation; D009976:Orthomyxoviridae Infections / Q000821:virology*; D051381:Rats; D011917:Rats, Inbred Lew; D046048:Seals, Earless / Q000821:virology; D012692:Serial Passage; D014774:Virulence; D014779:Virus Replication
chemical_list: D006389:Hemagglutinins, Viral