Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist.
The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neuromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.
Ladenheim
E E
EE
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Taylor
J E
JE
Coy
D H
DH
Moran
T H
TH
D000818:Animals; D001483:Base Sequence; D001839:Bombesin / Q000378:metabolism; D004435:Eating / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D015287:Neurokinin B / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010446:Peptide Fragments / Q000378:metabolism; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
C092829:BIM 23127; D010446:Peptide Fragments; D010456:Peptides, Cyclic; C040794:neuromedin C; D015287:Neurokinin B; C038393:neuromedin B; D005947:Glucose; D001839:Bombesin