Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.
The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 microM) and free radical release in whole blood (47 microM), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.
Kulanthaivel
P
P
Sphinx Pharmaceuticals Corporation, Durham, North Carolina 27717.
Janzen
W P
WP
Ballas
L M
LM
Jiang
J B
JB
Hu
C Q
CQ
Darges
J W
JW
Seldin
J C
JC
Cofield
D J
DJ
Adams
L M
LM
D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013267:Stilbenes / Q000302:isolation & purification / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D013267:Stilbenes; D011493:Protein Kinase C