Regulation of transcription by the retinoblastoma protein.
The product of the retinoblastoma gene (RB1) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RB1 may exert its growth-suppressing activity by regulating the transcription of a variety of growth-related genes, including FOS, MYC, and TGFBI. A series of biochemical and molecular analyses suggest that RB1 indirectly affects gene expression via cell-cycle-regulated interactions with transcription factors, such as E2F and SPI. Determination of the mechanisms regulating such protein-protein interactions and the identification of additional targets of RB1 function will provide vital insights into the role of this tumor-suppressor gene in mammalian cell proliferation.
Horowitz
J M
JM
Section of Cell Growth, Regulation and Oncogenesis, Duke University Medical Center, Durham, NC 27710.
D017500:Adenovirus E1A Proteins / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence; D004268:DNA-Binding Proteins; D005134:Eye Neoplasms / Q000235:genetics; D005656:Fungal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D016161:Genes, Retinoblastoma; D016762:Genes, fos; D016259:Genes, myc; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D020652:Peptide Elongation Factor 2; D010445:Peptide Elongation Factors / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000502:physiology; D012175:Retinoblastoma / Q000235:genetics; D016160:Retinoblastoma Protein / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D016329:Sp1 Transcription Factor / Q000378:metabolism; D014157:Transcription Factors; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000235:genetics
D017500:Adenovirus E1A Proteins; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; C052130:GAL4 protein, S cerevisiae; D020652:Peptide Elongation Factor 2; D010445:Peptide Elongation Factors; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D029701:Saccharomyces cerevisiae Proteins; D016329:Sp1 Transcription Factor; D014157:Transcription Factors; D016212:Transforming Growth Factor beta