Are neostriatal dopamine receptors co-localized?
The postsynaptic effects of dopamine in the neostriatum are mediated by five G-protein-coupled receptors. The extent to which these receptors are co-localized in neostriatal neurons has become controversial. This debate has far-reaching implications for treatment strategies in disorders of dopaminergic signaling, such as Parkinson's disease and schizophrenia. This review examines the molecular and cellular evidence for and against co-localization, including new information derived from single-cell mRNA amplification and patch-clamping of isolated neurons. It is concluded that this evidence is largely consistent with co-localization of functionally significant receptors of the D1 and D2 families in the majority of neostriatal efferent neurons. This conclusion has important implications for parallel processing models of the neostriatum.
Surmeier
D J
DJ
Dept of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163.
Reiner
A
A
Levine
M S
MS
Ariano
M A
MA
D000818:Animals; D006801:Humans; D017072:Neostriatum / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*
D011954:Receptors, Dopamine