Effects of hemodialysis on prostate-specific antigen.
We undertook a prospective study to evaluate the effects of hemodialysis on serum prostate-specific antigen (PSA) in 26 male patients with end-stage renal disease as a clinical model for assessing the role of the kidney in PSA clearance. Patients ranging in age from fifty-one to eighty-three years (mean 64.8 years) underwent phlebotomy immediately before and after outpatient hemodialysis on a Monday/Wednesday/Friday or Tuesday/Thursday/Saturday schedule, with serum PSA values determined by the Abbott IMX Microparticle Enzyme Immunoassay. The mean +/- standard deviation for all post-dialysis PSA levels, 2.43 +/- 3.74, was significantly greater than that for pre-dialysis levels, 2.11 +/- 3.19 (p = 0.04). However, no statistically significant differences were found on comparing the combined pre- and post-dialysis PSA values over the course of the study (p = 0.2733) or when sequential pre-dialysis (p = 0.28) and post-dialysis (p = 0.92) levels were analyzed separately. We conclude that PSA is not eliminated by hemodialysis, and our results infer that it is not cleared by renal mechanisms.
Monath
J R
JR
Department of Urology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.
Burkart
J M
JM
Freedman
B I
BI
Pittaway
D E
DE
Russell
G B
GB
Assimos
D G
DG
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood*; D006435:Renal Dialysis; D013997:Time Factors
D017430:Prostate-Specific Antigen