Nuclear lipid metabolism in NEST: Nuclear Envelope Signal Transduction.
There is increasing evidence that nuclear lipid metabolism in NEST is an important new component in signal transducing networks and as a result, this metabolism is beginning to attract more attention. While agonist-induced nuclear lipid metabolism adds further complexity to the ever increasing array of signal transduction components, it also provides further avenues by which nuclear activities may be regulated. Identification of the coupling mechanisms, regulation, and physiological roles of nuclear lipid metabolism represents a new and exciting area of research which will have a broad impact in our understanding of signal transduction pathways.
Raben
D M
DM
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Jarpe
M B
MB
Leach
K L
KL
D016475:3T3 Cells; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002460:Cell Line; D004075:Diglycerides / Q000378:metabolism; D004789:Enzyme Activation; D006868:Hydrolysis; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009685:Nuclear Envelope / Q000502:physiology*; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010743:Phospholipids / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D004075:Diglycerides; D008563:Membrane Lipids; D010743:Phospholipids; D016718:Arachidonic Acid; D011493:Protein Kinase C; D010727:Phosphoric Diester Hydrolases; D043265:Phosphatidylinositol Diacylglycerol-Lyase