Serum interleukin-1 beta is increased in cluster headache.
We measured serum interleukin-1 beta (IL-1 beta) in 24 episodic cluster headache (CH) patients and 45 normal controls using a specific ELISA method. There was an increase in IL-1 beta in all CH patients compared to controls. IL-1 beta was further increased during the ictal phase of CH compared to patients between attacks and normal individuals. Between attacks, IL-1 beta was also significantly increased compared to controls. We suggest that these results represent an activation of the immune system in CH.
Martelletti
P
P
Headache Centre, University La Sapienza, Rome, Italy.
Granata
M
M
Giacovazzo
M
M
D000328:Adult; D003027:Cluster Headache / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013373:Substance P / Q000378:metabolism
D007375:Interleukin-1; D013373:Substance P