KH domains within the FMR1 sequence suggest that fragile X syndrome stems from a defect in RNA metabolism.
Gibson
T J
TJ
European Molecular Biology Laboratory, Heidelberg, Germany.
Rice
P M
PM
Thompson
J D
JD
Heringa
J
J
D000595:Amino Acid Sequence; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D017354:Point Mutation; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism
D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D012313:RNA; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human