Insulin-like growth factor-I and binding protein-1 can modulate fetal brain cell growth during maternal starvation.
1. Stimulation of brain cell growth by fetal plasma is reduced when levels of IGF-I are low and IGFBP-1 are high. 2. Fetal brain cells respond to IGFs in cell culture, and effects of plasma are reduced by addition of IGFBP-1. 3. Increased levels of IGFBP-1 and reduced availability of IGF-I may contribute to reduced brain growth when maternal nutrition is impaired.
Shambaugh
G
G
Medical Research Service, VA Lakeside Medical Center, Chicago, Illinois.
Glick
R
R
Radosevich
J
J
Unterman
T
T
D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000196:embryology*; D002352:Carrier Proteins / Q000097:blood / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus; D005865:Gestational Age; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D013217:Starvation
D002352:Carrier Proteins; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I