Analysis of HLA-DR matching in DNA-typed cadaver kidney transplants.
The effect of matching for HLA-DR antigens was analyzed retrospectively in 3455 cadaver kidney transplants that were typed by the DNA-RFLP method. HLA-DR matching improved the one-year graft survival rate significantly (P < 0.01). Importantly, in 718 first transplants in which the number of mismatches assigned by serological typing was different from that assigned by DNA typing, only the DNA results showed a significant impact of matching on graft outcome (P = 0.03). These results demonstrate that DNA typing is clinically relevant. We were unable to confirm that the HLA-DR6 specificity or the DR6-split DRB1*1302 are associated with poor graft survival.
Opelz
G
G
Transplant Laboratory, Universities of Heidelberg, Germany.
Mytilineos
J
J
Scherer
S
S
Dunckley
H
H
Trejaut
J
J
Chapman
J
J
Fischer
G
G
Fae
I
I
Middleton
D
D
Savage
D
D
D002102:Cadaver; D004247:DNA / Q000032:analysis; D000939:Epitopes; D006684:HLA-DR Antigens / Q000032:analysis* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D012150:Polymorphism, Restriction Fragment Length
D000939:Epitopes; D006684:HLA-DR Antigens; D004247:DNA