Protective effect of sulfoethylglucan against hexavalent chromium.
The effect of pretreatment with sulfoethylglucan (SEG) on the frequency of micronuclei and the liver alkaline phosphatase activity induced by potassium bichromate (Cr(VI)) in mice was evaluated. Simultaneous application of SEG and Cr(VI) decreased the frequency of micronuclei in bone marrow cells (P < 0.01) and the level of liver alkaline phosphatase activity in comparison to the Cr(VI) group. Pretreatment with SEG 24 h prior to the first Cr(VI) application resulted in a more pronounced decrease in the Cr(VI)-induced frequency of micronuclei. The mechanisms of the protective effects of sulfoethylglucan could be explained either by the formation of Cr ion complexes with sulfoethyl groups of glucan or by the scavenging ability of SEG to trap hydroxyl radicals.
Chorvatovicová
D
D
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
Kováciková
Z
Z
Sandula
J
J
Navarová
J
J
D000469:Alkaline Phosphatase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells; D005260:Female; D005936:Glucans / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D051379:Mice; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011192:Potassium Dichromate / Q000037:antagonists & inhibitors* / Q000633:toxicity
D016587:Antimutagenic Agents; D005936:Glucans; D009153:Mutagens; D000469:Alkaline Phosphatase; D011192:Potassium Dichromate