Effects of cilazapril on cardiac structure and function in hypertension.
Peripheral vascular resistance, arterial blood pressure, and left ventricular hypertrophy (LVH) are closely related. In systemic hypertension, hemodynamic changes in systolic and diastolic function accompany LVH. Both of these cardiac functions are detected with echocardiography and were measured during this study in 23 essential hypertension patients treated with 2.5-5 mg of cilazapril daily for 6 months. Reduction in left ventricular mass was accompanied by an improvement in early diastolic filling pattern. This change in cardiac performance with cilazapril vasodilator monotherapy was characterized by a significant improvement in isovolumic relaxation time and normalized left ventricular early/atrial filling ratio.
Moisejev
V S
VS
Department of Internal Medicine and Clinical Pharmacology, Russian Peoples' Friendship University, Moscow.
Ivleva
A Y
AY
Gurochkin
A B
AB
Kobalava
Z D
ZD
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D017315:Cilazapril / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D015150:Echocardiography, Doppler / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D017315:Cilazapril