The role of the hypothalamic paraventricular nucleus upon the activity of thyroid and adrenal glands and their relation with body defense function.
Lesion of the PVH or its isolation--either alone or together with the medial hypothalamus, at fronto-lateral or complete level, induces a significant decrease in plasma thyroxine and a negligible modification of triiodothyronine. Variations recorded with various groups, having the medial hypothalamus deconnected, suggest that the main thyroliberin secreting (TRH) region is located at the level of PVH. Immunization of animals restores the thyroid function in the animals with damaged PVH, under the action of thyrotropin (TSH) of lymphocyte origin. Although the main CRH source occurs at the level of PVH, the results obtained after lesions or isolations of the hypophysotropic region demonstrate the extended distribution of CRH within various nervous areas, and its possible involvement in maintaining the adrenal gland function.
Hefco
V P
VP
Department of Physiology, Al. I. Cuza University, Iasi, Romania.
Olariu
A
A
Petraşcu
A
A
Robu
A
A
D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004912:Erythrocytes / Q000276:immunology; D007033:Hypothalamus, Middle / Q000502:physiology / Q000601:surgery; D007109:Immunity; D007114:Immunization; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology* / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep / Q000097:blood; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine; D003345:Corticosterone