title: Dietary fat and blood pressure.
abstract: Both animal and human data suggest that polyunsaturated fatty acids of n-6 and n-3 series may play a role in blood pressure regulation. The majority of dietary intervention studies have shown that changing from a high fat, low linoleic acid diet to a low fat, high linoleic acid diet lowers blood pressure. However, controlled, double-bind studies do not support the independent effect of linoleic acid. Polyunsaturated n-3 fish fatty acids lower blood pressure but only in pharmacological doses that cannot generally be recommended. The mechanisms of blood pressure regulation by n-6 and n-3 fatty acids seem to be related to prostaglandin metabolism.
authors.affiliation: National Public Health Institute, Department of Nutrition, Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Pietinen
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D018849:Controlled Clinical Trials as Topic; D003430:Cross-Sectional Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D006973:Hypertension / Q000178:diet therapy; D011453:Prostaglandins / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D011453:Prostaglandins