title: [Helix-coil transition in the simplest model of large native RNA. I. Consideration of only native helices].
abstract: A simple model of secondary structure of large native RNAs is proposed. The recurrence approach is described allowing to investigate helix-coil transition for this model by computer simulations. "Broken like" behavior of molecules of geometrical size has been observed upon changing the stability of helices at smooth changing of the helix fraction. Such behavior may be explained by the fact that helices formed by interactions between remote parts of the chain melt cooperatively by the mechanism of the second order phase transition. At the same time, helices formed by interactions between proximate segments in the chain melt practically independent of each other.
authors.forename: A M
authors.initials: AM
authors.lastname: Gutin
authors.forename: O V
authors.initials: OV
authors.lastname: Galzitskaia
mesh_terms: D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D012313:RNA