title: Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-selectin) during acute Plasmodium falciparum malaria.
abstract: Acute P. falciparum malaria is associated with a loss of antigen-responsiveness of peripheral T cells, depletion of T cells characterized by high surface expression of the adhesion molecule LFA-1, and increased plasma levels of the T-cell activation marker soluble IL-2 receptor (sIL-2R). In the present study we show that clinical episodes of P. falciparum malaria produced an increase in plasma levels of soluble ICAM-1 (sICAM-1) and ELAM-1 (sELAM-1). The increase was transient and subsided slowly (sICAM-1) or rapidly (sELAM-1) following drug cure. The increases in plasma sICAM-1 and sELAM-1 were significantly correlated, and were furthermore associated with a concomitant increase in plasma levels of sIL-2R. Finally, plasma levels of sICAM-1, but not sELAM-1, were inversely correlated to the fraction of peripheral T cells having high surface expression of LFA-1, the receptor for T-cell adhesion to ICAM-1. Taken together, these observations suggest that acute P. falciparum malaria is characterized by a state of endothelial inflammation associated with the adherence of activated T cells.
authors.affiliation: Department of Infectious Diseases, University Hospital, Copenhagen, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Hviid
authors.forename: T G
authors.initials: TG
authors.lastname: Theander
authors.forename: I M
authors.initials: IM
authors.lastname: Elhassan
authors.forename: J B
authors.initials: JB
authors.lastname: Jensen
mesh_terms: D000208:Acute Disease; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000097:blood*; D019040:E-Selectin; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D008213:Lymphocyte Activation; D016778:Malaria, Falciparum / Q000097:blood*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012995:Solubility; D013601:T-Lymphocytes
chemical_list: D015815:Cell Adhesion Molecules; D019040:E-Selectin; D015375:Receptors, Interleukin-2; D018799:Intercellular Adhesion Molecule-1