title: [Prenatal diagnosis and treatment of fetal hypothyroid goiter].
abstract: We report on a case of fetal goitrous hypothyroidism confirmed by the study of fetal thyroid function. Two injections of intra amniotic levo-thyroxine were performed at 35 and 36 WA. The serial ultra sonographic examination showed the disappearance of the fetal goiter. A healthy baby were delivered by cesarean section at 37 WA. At birth, the thyroid gland was slightly enlarged and the neonatal thyroid hormones were within the normal range. This case suggests that cordocentesis is a reliable method of assessing the status of the fetal thyroid, and that even as early as 35 WA a prenatal treatment of fetal goitrous hypothyroidism is possible by amniocentesis.
authors.affiliation: Service de Gynécologie-Obstétrique B, Hôpital Pellegrin, Bordeaux.
authors.forename: A L
authors.initials: AL
authors.lastname: Alfonso-Fischbach
authors.forename: C
authors.initials: C
authors.lastname: Guegan
authors.forename: R
authors.initials: R
authors.lastname: Saura
authors.forename: B
authors.initials: B
authors.lastname: Maugey-Laulom
authors.forename: B
authors.initials: B
authors.lastname: Sandler
authors.forename: J
authors.initials: J
authors.lastname: Horovitz
mesh_terms: D000328:Adult; D000650:Amnion; D005260:Female; D006042:Goiter / Q000175:diagnosis / Q000188:drug therapy / Q000196:embryology; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000188:drug therapy / Q000196:embryology; D007267:Injections; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000627:therapeutic use; D016216:Ultrasonography, Prenatal
chemical_list: D013974:Thyroxine