title: A technique for studying the function of an isolated, perfused and ventilated lung in a rat model.
abstract: We describe a technique which allows perfusion of an isolated, ventilated rat lung with an extracorporeal veno-venous circuit from a support animal. This model provides stable and reliable function of the isolated lung for up to 3 h, thus overcoming some of the disadvantages of previous models. It may prove a potentially useful model for assessing ischaemic lung injury.
authors.affiliation: Department of Cardiothoracic Surgery, Wythenshawe Hospital, Manchester, UK.
authors.forename: D N
authors.initials: DN
authors.lastname: Hopkinson
authors.forename: N J
authors.initials: NJ
authors.lastname: Odom
authors.forename: R M
authors.initials: RM
authors.lastname: Eloakley
authors.forename: J
authors.initials: J
authors.lastname: Au
authors.forename: T L
authors.initials: TL
authors.lastname: Hooper
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D008168:Lung / Q000098:blood supply / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury; D012121:Respiration, Artificial; D014021:Tissue Preservation