Acute non-lymphocytic leukemia with expression of surface antigen CD7--morphological, cytochemical, immunological and ultrastructural features in eight patients.
Of late, there has been an increase in the number of acute leukemias coexpressing markers believed to be restricted to a single lineage. Eight patients with ANLL whose blast coexpressed the T cell associated CD7 antibody were identified among 462 consecutive ANLL cases. Seven had FAB defined AML according to morphocytochemical criteria, whereas one patient was classified as MO on the basis of ultrastructural studies. The incidence of CD7 positivity was particularly significant in the less differentiated sub-types MO and M1 compared to other FAB sub-groups. Detailed long term studies will be required to realize their biological and clinical significance.
Chopra
H K
HK
Dept. of Medical Oncology, Tata Memorial Hospital, Parel, Bombay.
Nair
C N
CN
Barbhaya
S A
SA
Dhond
S R
SR
Badrinath
Y
Y
Kumar
A
A
Zachariah
L V
LV
Advani
S H
SH
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte / Q000097:blood*; D000954:Antigens, Surface / Q000097:blood*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D015703:Antigens, CD; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface