Effects of radioiodine therapy in hyperthyroidism (thyroid function, thyroid volume, Graves' ophtalmopathy, thyrotoxic heart disease).
The study group consisted of 135 hyperthyroid patients--128 with Graves' disease and 7 with toxic multinodular goiter. A single dose of radioiodine was given in 110 cases (81.48%), two doses in 22 patients (16.3%) and three doses in 3 patients (2.22%); mean total dose was 6.8 mCi (range = 3-24 mCi). The main goal of radio iodine therapy is to achieve euthyroidism; after radioiodine treatment, 61 patients (45.2%) were euthyroid, 60 patients (44.4%) with permanent hypothyroidism and 14 (10.36%) with PERSISTING HYPERTHYROIDISM--the mean duration of follow-up being 4.2 years. After radioiodine therapy, goiter became absent in 30 patients (28%); in those patients, goiter was moderately enlarged or large before therapy. Around 63% (12 cases) of the patients with thyrotoxic atrial fibrillation reverted to sinus rhythm. During the last four years (1990-1994) the patients with Graves' ophthalmopathy from the study group were treated with Prednisone after radioiodine therapy; this corticotherapy contributes to the lower percentage (1.5%) of worsening Graves' ophthalmopathy after radioiodine therapy.
Ursu
H I
HI
C. I. Parhon Institute of Endocrinology, Bucharest, Romania.
Dumitriu
L
L
Grigorie
D
D
Simescu
M
M
Vaida
E
E
Belgun
M
M
Popovici
D
D
D000328:Adult; D000368:Aged; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D006044:Goiter, Nodular / Q000532:radiotherapy; D006111:Graves Disease / Q000150:complications* / Q000532:radiotherapy; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D006980:Hyperthyroidism / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D007037:Hypothyroidism / Q000209:etiology; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000473:pathology / Q000503:physiopathology*; D013964:Thyroid Neoplasms / Q000209:etiology
D007457:Iodine Radioisotopes