title: Three-dimensional display of surface cortical perfusion by SPECT: application in assessing Alzheimer's disease.
abstract: To better understand cortical perfusion, we developed a method for a three-dimensional display technique with 99mTc-hexamethylpropyleneamine oxime (HMPAO) SPECT.
  
  
  METHODS
  Twelve patients with higher cortical dysfunction due to Alzheimer's disease and 18 age-matched controls were examined. Data acquisition was performed after intravenous injection of 740 MBq of 99mTc-HMPAO. After reconstructing the transaxial images, the three-dimensional images were obtained by modified volume rendering, where the surfaces were displayed in the corresponding colors as the maximum cortical value within a depth of 2 cm.
  
  
  RESULTS
  In the control studies, almost all surface cortices were over 60% of the maximum cerebellar value. In Alzheimer's disease patients, areas of perfusion below 60% were detected in the temporo-parietal lesions and frontal lobe lesions in 6 of 12. These findings correlated with the neurological dysfunction.
  
  
  CONCLUSIONS
  This method provides realistic three-dimensional information about surface cortical perfusion, which was found to be useful in clinical investigations of higher cortical dysfunction due to degenerative or cerebrovascular diseases.
authors.affiliation: Department of Nuclear Medicine, Osaka University Medical School, Suita, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hashikawa
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Moriwaki
authors.forename: N
authors.initials: N
authors.lastname: Oku
authors.forename: Y
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Seike
authors.forename: T
authors.initials: T
authors.lastname: Uehara
authors.forename: H
authors.initials: H
authors.lastname: Tanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Ohie
authors.forename: T
authors.initials: T
authors.lastname: Kamada
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime