[Mechanism of action of the antineoplastic antibiotic asterin on cellular factors of immunogenesis regulation].
Asterin is a novel antitumor antibiotic isolated from a medicinal plant of the aster family in the Department of Antibiotics of the Institute of Microbiology and Virology of the National Academy of Sciences of the Ukraine. The mechanisms of its influence on the host antitumor resistance were studied. Asterin was shown to promote the modulation of the specific and nonspecific link of the antitumor resistance. It activated to a definite extent the effector productive phase with the dominating influence on the proliferative phase. The antibiotic immunocorrective action was achieved via the recovery of the suppression mechanism controlling the proliferation and differentiation of all the cell populations. The molecular mechanisms of the asterin action on the lymphocyte transformation characterized by an increase in the metabolism and synthesis of the membrane phospholipids are likely associated with the control of their free radical processes.
Smirnov
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Mishenkova
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D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D010456:Peptides, Cyclic; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal
D000903:Antibiotics, Antineoplastic; D010456:Peptides, Cyclic; D010936:Plant Extracts; C066411:asterin