How specific is the first recognition step of homologous recombination?
The Escherichia coli RecA protein promotes homologous recognition in base triplets via non-Watson-Crick bonds that differ from those formed nonenzymically from DNA consisting of runs of purines or pyrimidines. Base substitutions reveal recognition to be permissive, consistent with a search for homology that achieves speed at the cost of precision.
Rao
B J
BJ
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Chiu
S K
SK
Bazemore
L R
LR
Reddy
G
G
Radding
C M
CM
D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D011938:Rec A Recombinases / Q000378:metabolism; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
C051802:triplex DNA; D004247:DNA; D011938:Rec A Recombinases