title: Tunnel capillaries in hypertrophied myocardium of rats with aorto-caval fistula.
abstract: Male inbred rats (Wag) with aorto-caval fistula were used as a model of volume-overloaded heart hypertrophy. Hearts were taken after 1, 2, and 6 months postoperatively for immunohistochemical, histological and ultrastructural investigations. Immunohistochemical staining with some anti-extracellular matrix antibodies and ultrastructural findings allowed us to recognize intracardiocytic tunnels which were intracellular invaginations of plasmalemma surrounded by basement membrane. Inside the tunnels endothelial cells forming well-developed capillaries were entrapped. Tunnel capillary formation is discussed as an adaptive response to increased cardiac work due to volume overload.
authors.affiliation: Department of Pathological Anatomy, Medical Academy of Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Ratajska
authors.forename: E
authors.initials: E
authors.lastname: Fiejka
authors.forename: M
authors.initials: M
authors.lastname: Maksymowicz
authors.forename: Z
authors.initials: Z
authors.lastname: Gawlik
mesh_terms: D000818:Animals; D001011:Aorta / Q000601:surgery; D001164:Arteriovenous Fistula; D001485:Basement Membrane / Q000648:ultrastructure; D002196:Capillaries / Q000473:pathology* / Q000648:ultrastructure; D002306:Cardiac Volume; D006332:Cardiomegaly / Q000473:pathology*; D002462:Cell Membrane / Q000648:ultrastructure; D003331:Coronary Vessels / Q000648:ultrastructure*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005353:Fibronectins / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007797:Laminin / Q000032:analysis; D008297:Male; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D009389:Neovascularization, Pathologic; D051381:Rats; D011919:Rats, Inbred Strains; D014684:Venae Cavae / Q000601:surgery
chemical_list: D005353:Fibronectins; D007797:Laminin