Inhibition of protein synthesis by cycloheximide does not prevent adaptive responses triggered by heavy metal salts in Vicia faba.
Copper sulfate, lead nitrate, and cadmium nitrate conditioning treatments of Vicia faba root tip meristem cells result in adaptive responses to triethylenemelamine (TEM)- and maleic hydrazide (MH)-induced genotoxic effects, i.e., they significantly reduce the yield of metaphases with chromatid aberrations. Contrary to adaptive responses triggered by low clastogen concentrations or heat shock, protective effects induced by heavy metals cannot be prevented by inhibition of protein synthesis and last for a much longer time span (up to at least 48 h). These and other data support the conclusion that the cells can react to the impact of external factors by various inducible functions which eventually protect their DNA from damage.
Michaelis
A
A
Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.
Rieger
R
R
D000222:Adaptation, Physiological / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity; D019187:Cadmium Compounds; D002869:Chromosome Aberrations; D003300:Copper / Q000633:toxicity; D019327:Copper Sulfate; D003513:Cycloheximide / Q000494:pharmacology*; D007887:Fabaceae / Q000187:drug effects* / Q000502:physiology; D007854:Lead / Q000633:toxicity; D008300:Maleic Hydrazide / Q000633:toxicity; D008670:Metals / Q000633:toxicity*; D008677:Metaphase; D009153:Mutagens / Q000633:toxicity; D009566:Nitrates / Q000633:toxicity; D010946:Plants, Medicinal; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D014265:Triethylenemelamine / Q000633:toxicity
D019187:Cadmium Compounds; D008670:Metals; D009153:Mutagens; D009566:Nitrates; D011500:Protein Synthesis Inhibitors; D002104:Cadmium; D007854:Lead; C017461:lead nitrate; D003300:Copper; D003513:Cycloheximide; D014265:Triethylenemelamine; D019327:Copper Sulfate; D008300:Maleic Hydrazide; C035196:cadmium nitrate