title: Isolation and biological activity of thielocins: novel phospholipase A2 inhibitors produced by Thielavia terricola RF-143.
abstract: Thielocins A2 alpha, A2 beta, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A2 inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1 alpha and A1 beta. The most potent inhibitory activity (IC50 = 0.0033 microM) against rat group II phospholipase A2 was shown by thielocin A1 beta. Against human group II phospholipase A2, thielocin B3 (IC50 = 0.076 microM) was the most potent.
authors.affiliation: Shinogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Matsutani
authors.forename: R
authors.initials: R
authors.lastname: Sakazaki
authors.forename: H
authors.initials: H
authors.lastname: Hinoo
authors.forename: N
authors.initials: N
authors.lastname: Uotani
authors.forename: T
authors.initials: T
authors.lastname: Tanimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
authors.forename: S
authors.initials: S
authors.lastname: Nakamoto
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D051381:Rats; D014966:Xanthenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D014966:Xanthenes; D010741:Phospholipases A; D054467:Phospholipases A2