[Immunohistochemical study of a new squamous cell carcinoma-associated antibody (YM-antibody) prepared from cultured laryngeal carcinoma cells].
A new antibody associated with squamous cell carcinoma, YM-Antibody, containing components of pI 5.95-6.10 fractions, was produced from cell cultures of squamous cell carcinoma of the larynx. To elucidate the immunological characteristics of YM-Antibody, it and 6 other commercially available antibodies were investigated immunohistochemically by applying them to squamous cell carcinomas and non-malignant tissues obtained from various regions of the head and neck. The results showed high positivity of YM-Antibody (85.0%) on squamous cell carcinoma and extremely low false-positivity (10.5%) on non-malignant tissue. These findings suggest that the diagnostic efficacy of this YM-Antibody is 76.2%, while that of the other antibodies was less than 50%. The YM-Antibody will be useful as a diagnostic tool for squamous cell carcinoma of the head and neck.
Takahashi
H
H
Department of Otolaryngology, Tokai University School of Medicine, Isehara.
D000912:Antibodies, Neoplasm / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000276:immunology*; D015843:Serpins
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D015843:Serpins; C051072:squamous cell carcinoma-related antigen