Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.
Sanfilippo
P J
PJ
Drug Discovery Division, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA.
Jetter
M C
MC
Cordova
R
R
Noe
R A
RA
Chourmouzis
E
E
Lau
C Y
CY
Wang
E
E
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000737:chemistry*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000737:chemistry*; D051379:Mice; D011720:Pyrazoles / Q000494:pharmacology*; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D016169:Lymphocyte Function-Associated Antigen-1; D011720:Pyrazoles; C092963:RWJ 50271; D013844:Thiazoles; D018799:Intercellular Adhesion Molecule-1