title: Efficacy of ivermectin against Setaria microfilariae in calves and cerebrospinal setariosis in sheep and goats.
abstract: Ten calves harboring microfilariae (Mf) were injected with ivermectin at a single dose of 200 micrograms/kg body weight. Thereafter, the number of calves harboring Mf was gradually reduced to 7, 2 and 0 by 1, 4 and 12 weeks, respectively and remained negative for microfilariae by 16 weeks after injection. Furthermore, none of 221 goats and sheep injected twice with ivermectin at a dose of 200 micrograms/kg body weight developed setariosis while 17 out of 303 non-injected animals suffered from that disease. Therefore, ivermectin was much effective for the eradication of Mf in calves and the prevention of setariosis in sheep and goats.
authors.affiliation: School of Agriculture, Ibaraki University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shirasaka
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: G
authors.initials: G
authors.lastname: Endou
authors.forename: Y
authors.initials: Y
authors.lastname: Adachi
authors.forename: N
authors.initials: N
authors.lastname: Taira
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D015511:Goat Diseases / Q000517:prevention & control*; D006041:Goats; D007559:Ivermectin / Q000627:therapeutic use*; D008842:Microfilariae / Q000187:drug effects; D012719:Setariasis / Q000188:drug therapy* / Q000517:prevention & control; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*
chemical_list: D007559:Ivermectin