title: Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen.
abstract: A hepatitis B core antigen (HBcAg) gene bearing the 39-amino-acid-long domain A of hepatitis B surface antigen (HBsAg) within the HBcAg immunodominant loop has been constructed and expressed in Escherichia coli. Chimeric capsids demonstrated HBs but not HBc antigenicity and elicited in mice B-cell and T-cell responses against native HBcAg and HBsAg.
authors.affiliation: Institute of Molecular Biology, Latvian Academy of Sciences, Riga.
authors.forename: G
authors.initials: G
authors.lastname: Borisova
authors.forename: B
authors.initials: B
authors.lastname: Arya
authors.forename: A
authors.initials: A
authors.lastname: Dislers
authors.forename: O
authors.initials: O
authors.lastname: Borschukova
authors.forename: V
authors.initials: V
authors.lastname: Tsibinogin
authors.forename: D
authors.initials: D
authors.lastname: Skrastina
authors.forename: M A
authors.initials: MA
authors.lastname: Eldarov
authors.forename: P
authors.initials: P
authors.lastname: Pumpens
authors.forename: K G
authors.initials: KG
authors.lastname: Skryabin
authors.forename: E
authors.initials: E
authors.lastname: Grens
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D002213:Capsid / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D004926:Escherichia coli / Q000235:genetics; D006510:Hepatitis B Antibodies / Q000276:immunology; D006512:Hepatitis B Core Antigens / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D016056:Immunodominant Epitopes / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D011817:Rabbits; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D000939:Epitopes; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D016056:Immunodominant Epitopes; D011994:Recombinant Proteins