title: [The pharmacokinetic modification of mutagenesis].
abstract: The mutagenic activity of some antitumor agents and the antituberculous agent isoniazid was studied by using some methods for estimating mutations on the Drosophila, mammals, and human cells. It was shown that mutagenic effects could be modified by adding various auxiliaries to the formulations of the drugs. The mechanisms of modifications were examined by pharmacokinetic techniques.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Revazova
authors.forename: V A
authors.initials: VA
authors.lastname: Bratslavskiĭ
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D001388:Aziridines / Q000493:pharmacokinetics / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D004331:Drosophila melanogaster; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016296:Mutagenesis / Q000187:drug effects*; D011205:Povidone; D011687:Purines / Q000493:pharmacokinetics / Q000494:pharmacology; D012996:Solutions; D013852:Thiotepa / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001388:Aziridines; D011687:Purines; D012996:Solutions; C007779:fotrin; C015893:pumitepa; D013852:Thiotepa; D011205:Povidone