Adhesion molecules in cell interactions.
During a successful immune response, several families of adhesion molecules participate in a cascade of binding events that lead to the binding of leukocytes, both to each other and to cell types such as the endothelium and epithelium. A central theme emerging from recent studies is that the function of an adhesion receptor cannot be inferred from its expression alone; rather, adhesion receptors are 'selected' to perform distinct effector functions based on their cell-background and factors present in the local microenvironment. Thus, adhesion receptors expressed on different cell-types may find themselves in different states of 'activation-readiness' and may be further selected by prevailing conditions in the microenvironment to bind tissue-specific ligands and mediate leukocyte effector functions such as homing or transendothelial migration.
Hogg
N
N
Imperial Cancer Research Fund, London, UK.
Landis
R C
RC
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000502:physiology; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000145:classification / Q000276:immunology / Q000502:physiology*; D019040:E-Selectin; D006801:Humans; D016023:Integrins / Q000502:physiology; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin; D037102:Lectins / Q000502:physiology; D008024:Ligands; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D005810:Multigene Family; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011971:Receptors, Immunologic / Q000502:physiology; D016201:Receptors, Lymphocyte Homing / Q000502:physiology; D015398:Signal Transduction
D000906:Antibodies; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015820:Cadherins; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D016023:Integrins; D037102:Lectins; D008024:Ligands; D016169:Lymphocyte Function-Associated Antigen-1; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D011971:Receptors, Immunologic; D016201:Receptors, Lymphocyte Homing; C070709:integrin alphaEbeta7; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin; D011505:Protein-Tyrosine Kinases