[The anti-arrhythmic activity of quinuclidine derivatives].
Experiments on conscious rabbits have shown that the quinuclidine bicarphene displays a sufficiently profound antiarrhythmic activity. The agent, 1.0 mg/kg, prevents and abolishes arrhythmias induced by calcium chloride, strophanthin, and epinephrine and fails to affect the cardiac arrhythmias caused by aconitine and barium chloride. Higher bicarphene doses (1.5-2.0 mg/kg) results in severe bradycardia in intact rabbits, slower atrioventricular conduction. It is suggested that the antiarrhythmic activity of bicarphene is associated with its effects on cardiomyocytic membranous Ca2+ transport.
Svistov
A S
AS
Skorobogatov
V I
VI
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011812:Quinuclidines / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D011812:Quinuclidines; C018139:bicarphene