Interferon system in patients with rheumatoid arthritis and sclerodermia systematica.
In the blood of patients with rheumatoid arthritis and/or sclerodermia systematica usually acid-labile interferon-alpha (IFN-alpha) was found. Blood leukocytes cannot be considered the source of its production as they spontaneously produce IFN-gamma identified with specific antiserum. Blood leukocytes of tested patients generated in vitro a reduced amount of staphylococcus enterotoxin A-induced IFN-gamma and virus-induced acid-labile IFN-alpha. This findings support the assumption of impaired functioning of T- and B-blood cells in autoimmune diseases. The production of Newcastle diseases virus-induced IFN-alpha and influenza virus-induced acid-stable IFN-alpha by patients' leukocytes has not been altered. Acid-labile IFN-alpha obtained from the blood of tested patients, IFN-gamma spontaneously generated by leukocytes in vitro and acid-labile IFN-alpha produced by leukocytes in vitro following induction with influenza virus show similar sensitivity to pH 2.0 and time patterns of the antiviral state development in human diploid fibroblast culture.
Scheglovitova
O N
ON
N. F. Gamaleya Research Institute of Epidemiology and Microbiology of the AMS, Moscow, Russia.
Balabanova
R M
RM
Kulieva
A M
AM
Seilanov
L S
LS
Anikina
N V
NV
Orlova
T G
TG
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D002478:Cells, Cultured; D006801:Humans; D007372:Interferons / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology; D008875:Middle Aged; D009522:Newcastle disease virus / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology*
D008070:Lipopolysaccharides; D007372:Interferons