Selective resistance of tachykinin-responsive cholinergic neurons in the quinolinic acid lesioned neostriatum.
We have studied changes on endogenous acetylcholine (ACh) release evoked by different agents from rat neostriatal slices after quinolinic acid (QA) injections. QA lesions induced a biphasic decrease on ACh release evoked by 1 microM glutamate and 50 mM KCl. ACh release evoked by selective tachykinin agonists was only significantly decreased by 250 nmol QA. These results suggest the presence of different functional cholinergic cell populations, with tachykinin-responsive cholinergic neurons selectively spared.
Arenas
E
E
Departament de Biologia Cellular i Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Facultat de Medicina, Spain.
Pérez-Navarro
E
E
Alberch
J
J
Marsal
J
J
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D066298:In Vitro Techniques; D008297:Male; D008845:Microinjections; D017072:Neostriatum / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D015288:Neurokinin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology*; D017378:Quinolinic Acid / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology
D005971:Glutamates; D010446:Peptide Fragments; C061060:neurokinin A (4-10), Nle(10)-; C062618:substance P, Sar(9)-Met(O2)(11)-; D013373:Substance P; D018698:Glutamic Acid; D011189:Potassium Chloride; D015288:Neurokinin A; D017378:Quinolinic Acid; D000109:Acetylcholine