Plasma adenosine concentrations are elevated in Dahl salt-sensitive rats.
We measured plasma levels of adenosine in Dahl salt-sensitive rats (DS) and Dahl salt-resistant rats (DR) to examine the potential role of adenosine in cardiovascular regulation in this type of hypertension. Plasma adenosine concentrations were significantly higher in DS than in DR. The NaCl content in the diet did not affect plasma adenosine concentration in either DS or DR. Significant positive correlation was found between adenosine concentrations and systolic blood pressure when the data for DS and DR were analyzed together. These results suggest that adenosine may play an important role in the pathophysiology of hypertension in DS.
Yamada
K
K
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Goto
A
A
Ishii
M
M
Yoshioka
M
M
Sugimoto
T
T
D000241:Adenosine / Q000097:blood*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D051381:Rats; D011919:Rats, Inbred Strains / Q000097:blood*; D012982:Sodium, Dietary / Q000494:pharmacology*; D013599:Systole
D012982:Sodium, Dietary; D000241:Adenosine