title: Interpretive criteria and quality control parameters for testing bacterial susceptibility to the fluoroquinolone PD131628.
abstract: For testing bacterial susceptibility to PD131628, a 5-micrograms disk and the following tentative interpretive criteria may be used: > or = 19 mm for susceptible (MIC, < or = 1.0 micrograms/ml), 16 to 18 mm for intermediate (MIC, 2.0 micrograms/ml), and < or = 15 mm for resistant (MIC, > or = 4.0 micrograms/ml). For standard quality control strains, the following limits are proposed: for Escherichia coli ATCC 25922, zones of 31 to 41 mm or a MIC of 0.002 to 0.016 micrograms/ml; for Pseudomonas aeruginosa ATCC 27853, zones of 26 to 34 mm or a MIC of 0.12 to 0.5 micrograms/ml; for Staphylococcus aureus ATCC 25923, zones of 27 to 33 mm; for Staphylococcus aureus ATCC 29213, a MIC of 0.03 to 0.12 micrograms/ml; and for Enterococcus faecalis ATCC 29212, a MIC of 0.12 to 0.5 micrograms/ml.
authors.affiliation: Clinical Microbiology Institute, Tualatin, Oregon 97062.
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
authors.forename: P C
authors.initials: PC
authors.lastname: Fuchs
authors.forename: S D
authors.initials: SD
authors.lastname: Allen
authors.forename: F C
authors.initials: FC
authors.lastname: Tenover
authors.forename: J H
authors.initials: JH
authors.lastname: Jorgensen
authors.forename: L B
authors.initials: LB
authors.lastname: Reller
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D004058:Diffusion; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests / Q000592:standards*; D009287:Naphthyridines / Q000494:pharmacology*; D011355:Prodrugs / Q000494:pharmacology; D011786:Quality Control; D013045:Species Specificity
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C092809:PD 131112; D011355:Prodrugs; C068217:PD 131628