Interaction of technical hexachlorocyclohexane and oxydemeton methyl 25 EC to female rats after dermal application.
Technical hexachlorocyclohexane (HCH, 100 mg/kg/day) and oxydemeton methyl 25 EC (125 mg/kg/day) to female rats for 7, 15 and 30 days individually and in combination through skin application caused pathomorphological changes in vital organs and significant enzymatic changes in liver and serum. However changes produced by the two compounds in combination were not suggestive of potentiation effect at the tested dose level in female rats.
Raizada
R B
RB
Industrial Toxicology Research Centre, Lucknow, India.
Srivastava
M K
MK
Singh
R P
RP
Kaushal
R A
RA
Gupta
K P
KP
Dikshith
T S
TS
D000279:Administration, Cutaneous; D000818:Animals; D001921:Brain / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity; D008099:Liver / Q000187:drug effects; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012867:Skin / Q000187:drug effects
D007306:Insecticides; D009946:Organothiophosphorus Compounds; D001556:Hexachlorocyclohexane; C026086:methyl demeton