[Hepatocyte receptors for proteinase inhibitor complexes with plasmin].
Hepatocyte receptors have been found for such complexes as alpha 2-macroglobulin-plasmin, pregnancy-associated plasma protein A-plasmin, and pregnancy-associated alpha 2-glycoprotein-plasmin, molecular masses of these receptors being estimated. The proteinaceous component of hepatocyte membranes contains heavy chains of plasmin and a 50 kDa fragment of plasmin molecule. These chains and the fragment are able to bind the native alpha 2-antiplasmin. Using immunoblotting no hepatocyte receptors for native macroglobulins, and alpha 2-antiplasmin-plasmin, alpha 1-proteinase inhibitor were detected.
Zorin
N A
NA
Zhabin
S G
SG
Gorin
V S
VS
D002458:Cell Fractionation / Q000379:methods; D002846:Chromatography, Affinity; D002852:Chromatography, Ion Exchange; D005333:Fetus; D005341:Fibrinolysin / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D008970:Molecular Weight; D011257:Pregnancy Proteins / Q000032:analysis / Q000378:metabolism*; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis / Q000378:metabolism*; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000032:analysis / Q000378:metabolism*; D018000:Receptors, Peptide; D000979:alpha-2-Antiplasmin / Q000032:analysis / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000032:analysis / Q000378:metabolism*
D008565:Membrane Proteins; D011257:Pregnancy Proteins; D011956:Receptors, Cell Surface; D018000:Receptors, Peptide; D000979:alpha-2-Antiplasmin; D000511:alpha-Macroglobulins; C065181:plasmin receptor; C024668:plasmin-alpha(2)-macroglobulin complex; D005341:Fibrinolysin; D011266:Pregnancy-Associated Plasma Protein-A