title: Intracavitary radiation in the treatment of advanced esophageal carcinoma: a comparison of high dose rate vs. low dose rate brachytherapy.
abstract: Twenty-two patients were irradiated using two different dose schedules of intracavitary irradiation for palliation of locally advanced or metastatic carcinoma of the esophagus. Irradiation was given solely with either manually afterloaded low/intermediate dose Cesium-137 (LDR) or high dose rate Iridium-192 (HDR) delivered via remote afterloader. This study was designed to test the effectiveness of HDR intracavitary brachytherapy in the relief of dysphagia and the maintenance of esophageal patency and to compare with our previous experiences with LDR intracavitary brachytherapy. Accelerated treatments were especially suited for patients with poor physical condition or short life expectancy unlikely to complete a full course of external beam irradiation without treatment interruption. Two thousand cGY in three fractions of LDR was compared with 1,250 cGY in one fraction HDR with essentially equal results.
authors.affiliation: Department of Surgery, Southern California Permanente Medical Group, Los Angeles.
authors.forename: J C
authors.initials: JC
authors.lastname: Harvey
authors.forename: E H
authors.initials: EH
authors.lastname: Fleischman
authors.forename: J E
authors.initials: JE
authors.lastname: Bellotti
authors.forename: A R
authors.initials: AR
authors.lastname: Kagan
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D002277:Carcinoma / Q000150:complications / Q000401:mortality / Q000532:radiotherapy*; D002588:Cesium Radioisotopes / Q000627:therapeutic use; D003680:Deglutition Disorders / Q000209:etiology / Q000532:radiotherapy; D004938:Esophageal Neoplasms / Q000150:complications / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D010166:Palliative Care; D011879:Radiotherapy Dosage
chemical_list: D002588:Cesium Radioisotopes; D007496:Iridium Radioisotopes