Virulence characteristics of Escherichia coli in nosocomial urinary tract infection.
We examined 148 strains of Escherichia coli isolated from the urine from patients with nosocomial urinary tract infection (UTI). The prevalence of P fimbriation was only 11.5%. Of the strains, 17.6% expressed non-P M(R) adhesins (defined as strains expressing mannose-resistant but not P-specific hemagglutination); 33.1% produced hemolysin, and 15.2% expressed type 1C fimbriae. O6 was the most common group of O antigens (12.2%), closely followed by O75 (9.5%); both of these groups are relatively uncommon (4.5% and 1%, respectively) in fecal strains isolated from healthy adults. Of the strains with O6 and O75 antigens, 78.8% and 79% produced hemolysin, but of all other strains causing UTI, only 21% produced hemolysin. Of the strains with O6 antigens, 61% expressed non-P M(R) adhesins, but only 12% of all other strains causing UTI expressed non-P M(R) adhesins. There were no significant differences in the prevalence of virulence properties between strains isolated from patients with or without an underlying medical illness or between strains causing different clinical categories of UTI. We conclude that the prevalence of bacterial virulence factors is low among patients with nosocomial UTI.
Ikäheimo
R
R
Department of Medicine, Kuopio University Hospital, Finland.
Siitonen
A
A
Kärkkäinen
U
U
Mäkelä
P H
PH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001422:Bacterial Adhesion; D001437:Bacteriuria / Q000382:microbiology; D003428:Cross Infection / Q000382:microbiology*; D004926:Escherichia coli / Q000145:classification / Q000276:immunology / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005260:Female; D010861:Fimbriae, Bacterial; D006460:Hemolysin Proteins / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019081:O Antigens; D011135:Polysaccharides, Bacterial / Q000032:analysis; D011446:Prospective Studies; D012703:Serotyping; D014552:Urinary Tract Infections / Q000382:microbiology*; D014774:Virulence
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D006460:Hemolysin Proteins; C030659:K antigens; D019081:O Antigens; D011135:Polysaccharides, Bacterial