Induction of an adaptive response to dominant lethality and to chromosome damage of mouse germ cells by low dose radiation.
In the present paper, dominant lethal mutations, chromosome aberrations in spermatocytes and reciprocal translocations in stem spermatogonia were analyzed after whole body exposure of mice to X-radiation. Results both from chromosome aberrations in spermatocytes and for reciprocal translocations in spermatogonia showed that pre-exposure to low doses up to 200 mGy could induce a significant dose-dependent reduction in adapted mice compared to the non-adapted mice; the lower the adaptive dose, the greater the reduction. For dominant lethal mutations, it was found that spermatogonia (both stem cells and differentiated cells) and spermatocytes adapted to 50 mGy X-rays could show an adaptive response, but spermatids and spermatozoa could not.
Cai
L
L
Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, People's Republic of China.
Jiang
J
J
Wang
B
B
Yao
H
H
Wang
X
X
D000222:Adaptation, Physiological; D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009154:Mutation; D011829:Radiation Dosage; D013087:Spermatids / Q000528:radiation effects; D013094:Spermatozoa / Q000528:radiation effects* / Q000648:ultrastructure; D014178:Translocation, Genetic; D014916:Whole-Body Irradiation; D014965:X-Rays