Immunopathogenic mechanisms in experimental allergic encephalomyelitis.
Experimental allergic encephalomyelitis, a cell-mediated autoimmune disease, continues to provide interesting data on the mechanisms subserving organ-specific autoimmunity. The elements of the trimolecular complex have been further defined and the conserved molecular basis of the interaction between the T-cell receptor and the major histocompatibility complex class II-peptide antigen complex is better understood. This model also provides new insights into the cellular interactions within the brain during the course of the autoimmune inflammatory response.
Kálmán
B
B
National Institute for Neurology and Psychiatry, Budapest, Hungary.
Lublin
F D
FD
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D001921:Brain / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000628:therapy; D000949:Histocompatibility Antigens Class II / Q000502:physiology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy; D004676:Myelin Basic Protein / Q000276:immunology; D009457:Neuroglia / Q000276:immunology; D010455:Peptides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D004676:Myelin Basic Protein; D010455:Peptides; D011948:Receptors, Antigen, T-Cell