[New approaches to the study of central nervous system regulation mechanisms].
The paper discusses whether microdialysis can be used for follow-ups of the biochemical bases of human and animal brain functions. This technique provided evidence for varying norepinephrine levels in various brain regions when the appetite-regulating centers are artificially stimulated, as well as for nicotine-induced changes of serotonin. The paper also demonstrates this technique in monkeys while studying stress in particular. Evidence is also given for the possibility of using the technique to follow-up the biochemical processes occurring in the human brain in case of studying the levels of dopamine, serotonin, and purines in parkinsonian patients. The formation of the new direction in neurobiology--functional biochemistry of the brain--is stated in the paper.
Chazov
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D000818:Animals; D001069:Appetite Regulation; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D005500:Follow-Up Studies; D000882:Haplorhini; D006801:Humans; D017551:Microdialysis; D009538:Nicotine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism*; D011687:Purines / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D000697:Central Nervous System Stimulants; D011687:Purines; D012701:Serotonin; D009538:Nicotine; D004298:Dopamine; C030985:purine; D009638:Norepinephrine