[Local injection of peplomycin adsorbed on activated carbon particles combined with 60Co radiation against inoperable advanced esophageal cancer--two long-term survivors].
We have developed a new dosage form, PEP-CH, consisting of peplomycin adsorbed onto small activated carbon particles. Ten patients with inoperable advanced esophageal cancer were treated with endoscopic local injection of PEP-CH combined with radiation using 60Co. Two of 5 patients who completed the treatment have survived over one year (19 and 23 months) now.
Oyama
T
T
First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Sakakibara
T
T
Ozaki
K
K
Tsujimoto
H
H
Sasaki
S
S
Sakakura
C
C
Shimotsuma
M
M
Hagiwara
A
A
Kojima
O
O
Takahashi
T
T
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D002244:Carbon; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017663:Peplomycin; D011379:Prognosis
D000903:Antibiotics, Antineoplastic; D003037:Cobalt Radioisotopes; D003692:Delayed-Action Preparations; D001761:Bleomycin; D017663:Peplomycin; D002244:Carbon