An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro.
Ten known or suspected aneugens were analyzed in a variety of in vitro mammalian cell cultures using different endpoints which included: micronuclei, kinetochore-positive micronuclei in binucleated cells, changes in the number of chromosomes or aberrations of mitosis and division. Human lymphocytes, human diploid fibroblasts and Chinese hamster transformed cells were used as target cells. The relative merits of different in vitro test systems employed are briefly discussed here.
Natarajan
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MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands.
D000782:Aneuploidy; D000818:Animals; D002104:Cadmium / Q000633:toxicity; D019256:Cadmium Chloride; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D002697:Chloral Hydrate / Q000633:toxicity; D002712:Chlorides / Q000633:toxicity; D002869:Chromosome Aberrations; D003078:Colchicine / Q000633:toxicity; D006224:Cricetinae; D003412:Cricetulus; D003975:Diazepam / Q000633:toxicity; D004464:Econazole / Q000633:toxicity; D005347:Fibroblasts; D006801:Humans; D006873:Hydroquinones / Q000633:toxicity; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D015162:Micronucleus Tests / Q000379:methods; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity*; D011739:Pyrimethamine / Q000633:toxicity; D013827:Thiabendazole / Q000633:toxicity; D013849:Thimerosal / Q000633:toxicity; D014747:Vinblastine / Q000633:toxicity
D002712:Chlorides; D006873:Hydroquinones; D009153:Mutagens; D002104:Cadmium; D013849:Thimerosal; D002697:Chloral Hydrate; D014747:Vinblastine; D004464:Econazole; D019256:Cadmium Chloride; D013827:Thiabendazole; D003975:Diazepam; D003078:Colchicine; C031927:hydroquinone; D011739:Pyrimethamine