Sialyltransferase: a novel acute-phase reactant.
1. Proteins that are released into the circulation in elevated amounts in injured mammals are referred to as acute-phase reactants. Most are liver synthesized glycoproteins of the secretable type. However, Gal-beta(1-->4)-GlcNAc-alpha(2-->6)-sialyltransferase (EC 2.4.99.1) is a novel acute-phase reactant since it is a Golgi membrane-bound enzyme rather than a secretable glycoprotein. 2. The role of glucocorticoids and cytokines in the control of synthesis and expression of acute-phase glycoproteins, including sialyltransferase, is discussed. 3. The acute-phase behaviour of Gal-beta(1-->4)-GlcNAc-alpha(2-->6)-sialyltransferase is dependent on the release of the enzyme from the Golgi in the acute-phase state. The mechanism of release of a catalytically active form of the enzyme is described.
Jamieson
J C
JC
Department of Chemistry, University of Manitoba, Winnipeg, Canada.
McCaffrey
G
G
Harder
P G
PG
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D015870:Gene Expression; D006056:Golgi Apparatus / Q000201:enzymology; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure; D012799:Sialyltransferases / Q000378:metabolism*; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
D000209:Acute-Phase Proteins; D012799:Sialyltransferases; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase