Acute promyelocytic leukemia with CD59 deficiency.
CD59 is a phosphatidyl inositol-anchored protein (which is lost in paroxysmal nocturnal hemoglobinuria (PNH) cells) with the capacity to block the formation of membrane attack complex, and protects host cells from autologous complement-mediated cytolysis. We found a patient with acute promyelocytic leukemia (APL) accompanied by disseminated intravascular coagulation (DIC), the cells of which were CD59-negative. Although the CD59 deficiency in the malignant cells was not related to PNH, we offered the possibility that DIC was induced by APL lysis secondary to the deficiency of CD59.
Seya
T
T
Department of Immunology, Center for Adult Diseases Osaka, Japan.
Tejima
H
H
Fukuda
H
H
Hara
T
T
Matsumoto
M
M
Hatanaka
M
M
Sugita
Y
Y
Masaoka
T
T
D000368:Aged; D015703:Antigens, CD / Q000502:physiology*; D018957:CD59 Antigens; D015938:Complement Membrane Attack Complex / Q000037:antagonists & inhibitors; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000172:deficiency* / Q000502:physiology
D015703:Antigens, CD; D018957:CD59 Antigens; D015938:Complement Membrane Attack Complex; D008562:Membrane Glycoproteins