PA-I and PA-II lectin interactions with the ABO(H) and P blood group glycosphingolipid antigens may contribute to the broad spectrum adherence of Pseudomonas aeruginosa to human tissues in secondary infections.
Pseudomonas aeruginosa may cause serious infections in most human tissues/organs. Its adherence to them is mediated by a battery of adhesins including the PA-I and PA-II lectins, which are produced in this bacterium in high quantities. PA-I binds to the D-galactose of the erythrocyte glycosphingolipids exhibiting highest affinities for B and Pk (followed by P1) antigens, while PA-II preferentially binds to the L-fucose of H, A and B antigens. Intact P. aeruginosa cells also exhibit a clear Pk and P1 over p preference. Such affinities for the most common human ABH and P system antigens may underlie the widespread tissue infectivity and pathogenicity of this bacterium.
Gilboa-Garber
N
N
Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Sudakevitz
D
D
Sheffi
M
M
Sela
R
R
Levene
C
C
D000017:ABO Blood-Group System / Q000378:metabolism*; D018829:Adhesins, Bacterial; D000328:Adult; D000941:Antigens / Q000378:metabolism; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000378:metabolism*; D002240:Carbohydrate Sequence; D006028:Glycosphingolipids / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D037102:Lectins; D008969:Molecular Sequence Data; D010127:P Blood-Group System / Q000378:metabolism*; D011552:Pseudomonas Infections / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000378:metabolism*
D000017:ABO Blood-Group System; D018829:Adhesins, Bacterial; D000941:Antigens; D001426:Bacterial Proteins; D006028:Glycosphingolipids; D037102:Lectins; D010127:P Blood-Group System; C038692:adhesin, Pseudomonas