Myelin-oligodendroglia complex in rats subjected to experimental cardiac arrest.
In an experimental model of clinical death induced in rats using the method of Korpachev et al. (1982) the myelinoligodendroglia complex was evaluated using the morphometric method of investigation. The results documented acute oedema of oligodendroglia nuclei in the early period, and degenerative changes later on. The studies of myelinated fibers seem to testify some differences in sensitivity according to the axon and myelin diameter on the influence of ischemia. The later changes of myelinated nervous fibers in the postresuscitation syndrome seem to be the secondary effect of autoimmune dependent neuronal destruction, whereas the alterations of oligodendroglia only partially contribute to the myelin lesion.
Wender
M
M
University of Medical Sciences, Department of Neurology, Poznań, Poland.
Szczech
J
J
D000818:Animals; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology*; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000473:pathology*; D008297:Male; D009186:Myelin Sheath / Q000473:pathology*; D009836:Oligodendroglia / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar