Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
Moussaoui
S
S
Rhone-Poulenc Rorer, Centre de Recherches de Vitry-Alfortville, Vitry-sur-Seine, France.
Carruette
A
A
Garret
C
C
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D004558:Electric Stimulation; D005557:Formaldehyde; D007211:Indoles / Q000494:pharmacology*; D007249:Inflammation / Q000503:physiopathology*; D054833:Isoindoles; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000187:drug effects / Q000502:physiology*; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013373:Substance P / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology
D000700:Analgesics; D000927:Anticonvulsants; D007211:Indoles; D054833:Isoindoles; D011758:Pyrroles; D013876:Thiophenes; C054718:PD 117302; C071693:7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one; D005557:Formaldehyde; D013373:Substance P; D009020:Morphine