The new monodendritic neuronal type within the adult human cerebellar granule cell layer shows calretinin-immunoreactivity.
The distribution of calretinin immunoreactive structures within the granule cell layer of the adult human cerebellar cortex was studied using the avidin-biotin peroxidase method. Immunoreactivity is found in numerous fibers and glomerular formations, in Golgi- and Lugaro cells as well as in a recently described novel neuronal type, the monodendritic cell. The soma of the monodendritic neuron contains a faintly stained nucleus and issues a single short dendrite terminating in a tuft. Most probably, the tuft contributes to the formation of a glomerulum. Soma and tuft are of about the same size (diameter 10-18 microns). The number of monodendritic neurons is higher in the vermal than in the hemispheric part of the lobulus (lobulus VII) and is higher in lobulus X than in lobulus VII of the vermis.
Braak
E
E
Zentrum der Morphologie, J.W. Goethe Universität, Frankfurt am Main, FRG.
Braak
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001360:Avidin; D001710:Biotin; D064032:Calbindin 2; D002467:Cell Nucleus / Q000648:ultrastructure; D002525:Cerebellar Cortex / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D002529:Cerebellar Nuclei / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D002531:Cerebellum / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D003712:Dendrites / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D064030:S100 Calcium Binding Protein G / Q000276:immunology / Q000378:metabolism*; D013194:Staining and Labeling
C576764:CALB2 protein, human; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G; D001360:Avidin; D001710:Biotin