title: [Extravasation of paclitaxel (Taxol)].
abstract: Paclitaxel is a new antimitotic derived from yew-tree, used for the treatment of ovarian and breast cancers. The local toxicity of paclitaxel is still poorly known. We report one of the first observations of accidental subcutaneous extravastion of paclitaxel. Local epidermic necrosis was observed and evolution was good with local treatment only. Treatments of such extravasation are discussed.
authors.affiliation: Service de Médecine Interne-Oncologie, Hôpital Saint-Antoine, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Raymond
authors.forename: S
authors.initials: S
authors.lastname: Cartier
authors.forename: C
authors.initials: C
authors.lastname: Canuel
authors.forename: C
authors.initials: C
authors.lastname: Louvet
authors.forename: B
authors.initials: B
authors.lastname: Demuynck
authors.forename: M
authors.initials: M
authors.lastname: Debray
authors.forename: C
authors.initials: C
authors.lastname: Varette
authors.forename: S
authors.initials: S
authors.lastname: Baux
authors.forename: M
authors.initials: M
authors.lastname: Mimoun
authors.forename: A
authors.initials: A
authors.lastname: de Gramont
mesh_terms: D000368:Aged; D003875:Drug Eruptions / Q000209:etiology*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications*; D005260:Female; D006801:Humans; D009336:Necrosis; D017239:Paclitaxel / Q000009:adverse effects*; D012867:Skin / Q000473:pathology
chemical_list: D017239:Paclitaxel