Effect of beraprost sodium (BPS) on the postischemic neuropathological changes and stroke index after left carotid artery occlusion in gerbils.
We investigated the effect of beraprost sodium (BPS), a new prostacyclin analog, on behavioral and neuropathological changes induced by a 10-min occlusion of the left carotid artery in gerbils. Gerbils were treated orally with BPS (1-100 micrograms/kg) 30 min before occlusion. Pathological evaluation of neural damage in the CA1 region of the hippocampus was performed 7 d after the ischemic insults. In the symptomatic group, in which the stroke index score was > 10, symptomatic behaviors, such as head cocked, splayed out hind limb, circling, and various similar behaviors, were observed. Pathologically, almost all CA1 neurons were destroyed 7 d after ischemia in the symptomatic group. BPS improved the stroke index during ischemia and neuropathological changes 7 d later, with statistical significant improvement occurring at a dose of 100 micrograms/kg.
Ueno
S
S
Basic Research Laboratories, Toray Industries Inc., Kanagawa, Japan.
Miyauchi
Y
Y
Matsuda
S
S
Endoh
T
T
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002339:Carotid Arteries / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000473:pathology* / Q000523:psychology; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology* / Q000523:psychology; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors; C048081:beraprost; D011464:Epoprostenol