title: Tissue-type plasminogen activator (tPA) is the main plasminogen activator associated with isolated rat nerve growth cones.
abstract: Different studies in tissue culture have shown the involvement of plasminogen activators (PAs) in nerve growth-cone migration. We have studied PA activity associated with isolated rat brain growth cones. Fibrin-agarose zymographies show that tissue-type PA (tPA) is the main PA associated with these structures. After fractionation of growth cones, a slightly higher tPA activity was found associated with the particulate fraction. The present findings support the requirement of this protease for neurite growth.
authors.affiliation: Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: García-Rocha
authors.forename: J
authors.initials: J
authors.lastname: Avila
authors.forename: R
authors.initials: R
authors.lastname: Armas-Portela
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000502:physiology*; D001921:Brain / Q000166:cytology; D002465:Cell Movement; D002478:Cells, Cultured; D009419:Nerve Tissue Proteins / Q000502:physiology*; D016501:Neurites / Q000502:physiology; D051381:Rats; D010959:Tissue Plasminogen Activator / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins; D010959:Tissue Plasminogen Activator