Production of endothelin-1 induced by blood transfusion in premature infants.
We demonstrated a relationship between blood transfusion and plasma ET-1 levels in 10 premature infants with anemia. Changes in plasma ET-1 and lipoperoxide levels, blood pressure and available oxygen before and after the blood transfusion were determined. Plasma ET-1 levels were significantly elevated after blood transfusion (before: 8.0 +/- 2.8; after: 15.7 +/- 5.4 pg/ml, p < 0.01). A positive correlation was observed between plasma ET-1 levels and lipoperoxide levels (r = 0.887, p < 0.01). There was a significant correlation between plasma ET-1 levels and transfused blood volumes (r = 0.758, p < 0.01). No positive correlation was observed between plasma ET-1 levels and available oxygen. These results suggest that blood transfusion may be a stimulator of ET-1 overproduction and that it may lead to tissue injury through an endothelin-induced oxygen radical formation system.
Sasai-Takedatsu
M
M
Department of Pediatrics, Kansai Medical University, Osaka, Japan.
Kojima
T
T
Hirata
Y
Y
Kobayashi
Y
Y
D000328:Adult; D001803:Blood Transfusion; D016232:Endothelins / Q000096:biosynthesis*; D005260:Female; D006400:Hematocrit; D006439:Hemodynamics; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D010100:Oxygen / Q000097:blood
D016232:Endothelins; D006454:Hemoglobins; D008054:Lipid Peroxides; D010100:Oxygen