The effects of dietary calcium and chlordecone on cholinesterase, triglycerides, low density lipoproteins, and cholesterol in serum of rat.
Male, Sprague-Dawley rats were treated with 0, 1, 10, 50, 100 ppm chlordecone (Cd) mixed in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. A significant decrease in body weight gain was observed in 100 ppm of Cd-treated rats. Cholinesterase (ChE) activity was significantly decreased in serum of Ca-D rats. Chlordecone did not alter serum ChE activity in both Ca-S and Ca-D rats. However, Cd decreases serum triglycerides, low density lipoproteins (LDL) and cholesterol in both Ca-S and Ca-D rats. Rats fed with Ca-S or Ca-D diet exhibited differential sensitivity to Cd-toxicity. Decreased levels of serum triglycerides, LDL and cholesterol suggest that Cd might interfere in lipid metabolism.
Chetty
K N
KN
Department of Biological Sciences, Grambling State University, Louisiana 71245.
Walker
J
J
Brown
K
K
Ivie
G W
GW
D000818:Animals; D002136:Calcium, Dietary / Q000494:pharmacology*; D007631:Chlordecone / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D002802:Cholinesterases / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D002136:Calcium, Dietary; D008055:Lipids; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol; D002802:Cholinesterases; D007631:Chlordecone