Cholinergic dependency of stimulatory effects of neurotensin on exocrine pancreas in rats.
The biological activities of neurotensin, a 13-residue peptide, on the exocrine pancreas were examined in vitro using dispersed pancreatic acini and in vivo using conscious rats. Neurotensin had weak amylase stimulatory activity in vitro, but its injection at 0.6 or 2 nmol/kg/h stimulated pancreatic exocrine secretion in vivo. CR-1409, a cholecystokinin (CCK) receptor antagonist, partially inhibited neurotensin-stimulated pancreatic secretion, although neurotensin did not stimulate plasma CCK release. Atropine completely inhibited the pancreatic response to neurotensin. These results suggest that neurotensin has either a direct biological action on the exocrine pancreas or an action mediated by cholinergic nerve transmission, and that neurotensin does not have a major physiological role in inducing pancreatic secretion.
Shinozaki
H
H
Inatsuki Hospital, Fukuoka, Japan.
Miyasaka
K
K
Funakoshi
A
A
D000681:Amylases / Q000378:metabolism; D000818:Animals; D002766:Cholecystokinin / Q000097:blood; D002799:Cholinergic Fibers / Q000187:drug effects* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009496:Neurotensin / Q000097:blood / Q000494:pharmacology* / Q000502:physiology*; D010179:Pancreas / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical
D009496:Neurotensin; D002766:Cholecystokinin; D000681:Amylases