Interlaboratory surveys of the determination of tumour markers scatter and repeatability of the results.
Data collected between 1983 and 1991 in interlaboratory surveys of the determination of tumour markers are used to show the magnitude of the scatter of results from different laboratories for the analysis of a single quantity in a given matrix. These data also show that the varying specificity of different reagent combinations appears to make a considerable contribution to this scatter, and that the used reagent combinations were not of uniform quality over a relatively extended period. The results for the following tumour markers were studied: alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), human chorionic gonadotropin (hCG), human chorionic gonadotropin+beta-subunit (hCG+beta-hCG), tissue polypeptide antigen (TPA), carbohydrate antigen 19-9 (CA 19-9), cancer antigen 15-3 (CA 15-3), cancer antigen 125 (CA 125), prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA).
Kruse
R
R
Institut für Klinische Biochemie der Universität Bonn.
Geilenkeuser
W J
WJ
Röhle
G
G
D000135:Acid Phosphatase / Q000097:blood; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D006801:Humans; D007753:Laboratories / Q000592:standards*; D010455:Peptides / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D011933:Reagent Kits, Diagnostic / Q000592:standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019396:Tissue Polypeptide Antigen; D000509:alpha-Fetoproteins / Q000032:analysis
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D010455:Peptides; D011933:Reagent Kits, Diagnostic; D019396:Tissue Polypeptide Antigen; D000509:alpha-Fetoproteins; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen