Requirement for Lim1 in head-organizer function.
Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer.
Shawlot
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Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Behringer
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D000818:Animals; D001483:Base Sequence; D015415:Biomarkers; D001921:Brain / Q000166:cytology / Q000196:embryology; D017931:DNA Primers; D004627:Embryonic Induction / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology*; D017353:Gene Deletion; D015870:Gene Expression; D018390:Gene Targeting; D005801:Genes, Homeobox; D006257:Head / Q000196:embryology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D060850:LIM-Homeodomain Proteins; D008648:Mesoderm; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010641:Phenotype; D013234:Stem Cells; D014157:Transcription Factors
D015415:Biomarkers; D017931:DNA Primers; D018398:Homeodomain Proteins; D060850:LIM-Homeodomain Proteins; C499523:Lhx1 protein, mouse; D014157:Transcription Factors