Hepatotoxicity caused by the combined action of isoniazid and rifampicin.
A 35 year old black Somalian woman with miliary tuberculosis developed hepatotoxicity after a few days of treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol. After withdrawal of all drugs the liver profile returned to normal and remained so after challenge with isoniazid. Hepatotoxicity recurred when rifampicin was added, but it was well tolerated when reintroduced without isoniazid.
Askgaard
D S
DS
Medical Department P, Bispebjerg Hospital, Copenhagen, Denmark.
Wilcke
T
T
Døssing
M
M
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D012293:Rifampin / Q000009:adverse effects*; D014391:Tuberculosis, Miliary / Q000188:drug therapy
D007538:Isoniazid; D012293:Rifampin