title: Circularly permuted DNA, RNA and proteins--a review.
abstract: Circular permutation represents a form of macromolecular isomerization when the normal termini are covalently linked and new termini introduced by breaking the backbone elsewhere. Here, we describe implications of circular permutation on the folding and function of biologically relevant macromolecules. A method permitting the analysis of the folding of all circularly permuted isomers of RNA is presented that has been successfully applied for a tRNA and the binding site of the coliphage R17 coat protein.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309.
authors.forename: T
authors.initials: T
authors.lastname: Pan
authors.forename: O C
authors.initials: OC
authors.lastname: Uhlenbeck
mesh_terms: D000818:Animals; D001483:Base Sequence; D004270:DNA, Circular / Q000737:chemistry*; D008969:Molecular Sequence Data; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D012360:RNA, Transfer, Phe / Q000737:chemistry; D012441:Saccharomyces cerevisiae
chemical_list: D004270:DNA, Circular; D011506:Proteins; D012360:RNA, Transfer, Phe; D012313:RNA