Type I insulin-like growth factor receptors in human colorectal cancer.
Type I insulin-like growth factor (IGF) receptors have been recently characterised in human colorectal cancers. The aim of this study was to determine whether type I IGF receptor concentration may be related to prognostic variables in colorectal cancers. Saturation experiments with [125I]IGF-I were performed on membrane preparations of 46 frozen specimens (20 tumours, 26 controls) and analysed according to the Scatchard method. In all the studied cases, we found a single class of high affinity binding sites in both normal and malignant colorectal tissues (median 0.17 and 0.15 nmol/l, respectively). Using paired analysis, we found no significant difference in terms of type I IGF receptor concentration between malignant and normal colorectal tissues. There was also no relationship between type I IGF receptors and any of the tumour characteristics studied. This study does not support a critical role of the type I IGF receptors in the clinical management of colorectal cancers.
Adenis
A
A
Département d'Oncologie Medicale, Centre Oscar Lambret, Lille, France.
Peyrat
J P
JP
Hecquet
B
B
Delobelle
A
A
Depadt
G
G
Quandalle
P
P
Bonneterre
J
J
Demaille
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017526:Receptor, IGF Type 1 / Q000032:analysis*; D012004:Rectal Neoplasms / Q000737:chemistry*
D017526:Receptor, IGF Type 1