Effect of delayed specimen processing on cytomegalovirus antigenemia test results.
Blood samples held at either 4 degrees C or room temperature for 1 day had similar mean decreases in number of cytomegalovirus antigenemia-positive cells (52 to 55%) and similar false-negative test results (13 to 14%). After 2 days, samples held at 4 degrees C showed no further decline, whereas samples held at room temperature had a mean 81% decrease in positive cells, a 32% false-negative rate, and a more marked deterioration in cell morphology.
Landry
M L
ML
Clinical Virology Laboratory, Yale New Haven Hospital, Connecticut 06510.
Ferguson
D
D
Cohen
S
S
Huber
K
K
Wetherill
P
P
D000956:Antigens, Viral / Q000097:blood*; D016026:Bone Marrow Transplantation; D003080:Cold Temperature; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D005188:False Negative Reactions; D005455:Fluorescent Antibody Technique; D015658:HIV Infections / Q000150:complications; D006358:Hot Temperature; D006801:Humans; D007962:Leukocytes / Q000821:virology; D010750:Phosphoproteins / Q000097:blood; D013048:Specimen Handling; D013997:Time Factors; D014763:Viral Matrix Proteins / Q000097:blood
D000956:Antigens, Viral; D010750:Phosphoproteins; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa