title: Effect of local diets with added sucrose on glycemic profiles of healthy and diabetic Brazilian subjects.
abstract: OBJECTIVE
  We set out to determine the daily glycemic profile of healthy and non-insulin-dependent diabetes mellitus (NIDDM) persons and to test the hypothesis that small amounts of sucrose added to NIDDM meals would not change their responses.
  
  
  METHODS
  Thirteen NIDDM and six healthy volunteers participated in the study. They initially consumed a diet similar to their home diet and later a diabetic hospital dietary regimen, with and without 30 g/day sugar replacing equivalent food energy. The hospital diet included their usual foods: bread, milk, rice, beans, meat, vegetables and fruits at breakfast, lunch and dinner. To follow their glycemic profile we drew several blood samples during a 22-hour period.
  
  
  RESULTS
  The day-long plasma glucose profile of the NIDDM and healthy subjects showed similar patterns, increasing after the meals and returning later to baseline levels. The extra amount of sucrose consumed did not change the daily glycemic profile or the calculated glycemic area under the 22-hour glycemic curves. These results call attention to the importance of the 22-hour glycemic profile compared to other shorter glycemic indexes.
  
  
  CONCLUSIONS
  The 22-hour profile has obvious advantage for planning day-long diabetic diets, taking in consideration local daily foods and usual eating habits. Maintenance of a small and traditional amount of food, e.g., sucrose, without harmful effects to the subjects, is another advantage of this proposition. It improves patient compliance as well as social daily life.
authors.affiliation: Department of Medicine, Ribeiräo Preto School of Medicine-São Paulo University, Brazil.
authors.forename: J S
authors.initials: JS
authors.lastname: Marchini
authors.forename: J R
authors.initials: JR
authors.lastname: Fáccio
authors.forename: M M
authors.initials: MM
authors.lastname: Rodrigues
authors.forename: M R
authors.initials: MR
authors.lastname: Unamuno
authors.forename: M C
authors.initials: MC
authors.lastname: Foss
authors.forename: J E
authors.initials: JE
authors.lastname: Dutra-de-Oliveira
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D001938:Brazil / Q000453:epidemiology; D002940:Circadian Rhythm / Q000502:physiology; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000453:epidemiology / Q000378:metabolism; D004032:Diet / Q000592:standards*; D003927:Diet, Diabetic / Q000592:standards; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005260:Female; D005638:Fruit; D006801:Humans; D008297:Male; D008875:Middle Aged; D012275:Oryza; D010349:Patient Compliance; D013395:Sucrose / Q000494:pharmacology*; D014675:Vegetables
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D013395:Sucrose