Cytokine modulation of HIV expression.
Cytokines, the peptide hormones which control the homeostasis of the immune system and also play a fundamental role in inflammatory and immune mediated reactions, have been involved at multiple levels in the pathogenesis of the acquired immune deficiency syndrome (AIDS). Infection with the human immunodeficiency virus (HIV) has been shown to induce production of several cytokines both in vitro and in vivo. Conversely, several cytokines modulate the levels of HIV expression in infected cells of both T lymphocytic and mononuclear phagocytic lineage. Activated mononuclear cells, particularly B cells which are in a state of chronic activation in HIV infected individuals, release HIV-inductive cytokines and thus play a potentially important role in the pathogenesis of HIV infection.
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Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Fauci
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D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D001402:B-Lymphocytes / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000382:microbiology; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology*; D015967:Gene Expression Regulation, Viral / Q000187:drug effects*; D005809:Genes, Regulator; D015757:Genes, rev; D015756:Genes, tat; D006678:HIV / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D007372:Interferons / Q000494:pharmacology / Q000502:physiology; D007378:Interleukins / Q000494:pharmacology / Q000502:physiology; D008954:Models, Biological; D009000:Monocytes / Q000187:drug effects / Q000382:microbiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects*
D016207:Cytokines; D007378:Interleukins; D014157:Transcription Factors; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons