title: The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro.
abstract: Five spermicides including nonoxynol-9 were assessed under in-vitro conditions, for their inhibitory activity against two viruses capable of spread by sexual intercourse, herpes simplex virus type-2 (HSV-2) and the human immunodeficiency virus type-1. A further eight commercially-available spermicidal preparations containing varying concentrations of either nonoxynol-9 or nonoxynol-11 were also assessed for activity against HSV-2. All spermicides and spermicidal preparations tested showed inhibitory activity against both viruses over periods of time ranging from 30 sec to 5 min. This activity was dependent on the concentration of spermicide to which the viruses were exposed.
authors.affiliation: Department of Experimental and Clinical Microbiology, University of Sheffield Medical School, UK.
authors.forename: R
authors.initials: R
authors.lastname: Jennings
authors.forename: A
authors.initials: A
authors.lastname: Clegg
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D004143:Dioctyl Sulfosuccinic Acid / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D017137:Nonoxynol / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology; D013089:Spermatocidal Agents / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D001548:Benzalkonium Compounds; D013089:Spermatocidal Agents; D004143:Dioctyl Sulfosuccinic Acid; D017137:Nonoxynol; D011092:Polyethylene Glycols; C029270:menfegol