Near-haploid karyotype in a squamous cell lung carcinoma.
Cytogenetic analysis of a squamous cell lung carcinoma revealed a near-haploid karyotype with 27 chromosomes, in both primary cultures and an established cell line. The only chromosomes with two homologs present were chromosomes X, 5, 7, and 22. The two X chromosomes were early and late replicating, respectively. No structural rearrangements could be detected. In vitro, the clone evolved by duplication towards hyperdiploidy with 54 chromosomes.
Drouin
V
V
Laboratoire de Biologie de la Fertilité et de Cytogénétique, Hôtel-Dieu, Hôpital Laennec, Paris, France.
Viguié
F
F
Debesse
B
B
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002871:Chromosome Banding; D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics*; D008875:Middle Aged; D014407:Tumor Cells, Cultured