L-selectin-IgG chimera--in vitro and in vivo.
In order to perform their role as mediators of inflammation neutrophils must be able to extravasate from the blood into the surrounding tissue. The initial step in this process is the rolling of neutrophils along the endothelium and is mediated by adhesion molecules known as selectins. This review will discuss the in vitro and in vivo characterization of an L-selectin-IgG chimera. The aim of the studies being to understand the role that the selectins might play in inflammatory responses and hopefully control those that are chronic or lifethreatening.
Watson
S R
SR
Dept. of Immunology, Genentech Inc., South San Francisco, CA 94080.
D000818:Animals; D015815:Cell Adhesion Molecules / Q000737:chemistry* / Q000502:physiology; D003001:Cloning, Molecular; D007074:Immunoglobulin G / Q000737:chemistry* / Q000502:physiology; D066298:In Vitro Techniques; D007249:Inflammation / Q000276:immunology*; D019041:L-Selectin; D007962:Leukocytes / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000737:chemistry
D015815:Cell Adhesion Molecules; D007074:Immunoglobulin G; D011993:Recombinant Fusion Proteins; D019041:L-Selectin