title: [Effect of 764-3 on ConA receptors on rat alveolar macrophages].
abstract: The changes of concanavalin A (ConA) receptors on alveolar macrophage (AM) surfaces were observed by means of ConA-horseradish peroxidase gold labelling techniques. The results were as follows: 1) The average gold particle number on normal AM surfaces was 1.985 +/- 0.097/microns, distributed uniformly; 2) On AM activated by BLMA6, in vitro, this number had increased to 3.909 +/- 0.314/microns, P < 0.001 compared with the normal group; 3) On AM preincubated with 764-3, the average gold particle number was 1.577 +/- 0.090/microns, significantly lower than that in the BLMA6 group. All results suggest that 764-3 might partially inhibit the expression of ConA-R on AM activated by BL-MA6.
authors.affiliation: Institute of Basic Medical Sciences, Beijing.
authors.forename: S
authors.initials: S
authors.lastname: Chi
authors.forename: Y
authors.initials: Y
authors.lastname: Yan
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000494:pharmacology / Q000031:analogs & derivatives; D002462:Cell Membrane / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011952:Receptors, Concanavalin A / Q000187:drug effects* / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; C079053:IH 764-3; D011952:Receptors, Concanavalin A; C052656:bleomycin A6; D001761:Bleomycin