title: [Interstitial laser coagulation of benign prostatic hyperplasia].
abstract: We report on the new method of interstitial laser coagulation for the treatment of benign prostatic hyperplasia (BPH). The procedure is based on the interstitial application of Nd:YAG laser irradiation, delivered through a new light guide system. Such light applicators coagulate constant tissue volumes in a homogeneous manner, as proven by in vitro studies in different tissues, including surgically removed prostate adenoma. The extent of the coagulation is determined by laser power and irradiation time. At 5 W, for example, and during a 10-min period, this zone reached a diameter of up to 20 mm. Temperatures generated in the process were over 100 degrees C, as measured by time/space resolution. These results were confirmed by in vivo studies in canine prostates. In the course of 7 weeks, the coagulated areas formed scars with degeneration and fibrosis, accompanied by marked shrinking. Neighbouring organs were not affected. The method was successfully transferred to clinical practice. The application of the light guides to the lateral lobes was performed percutaneously from the perineum under transrectal ultrasound guidance. The median lobe was punctured transurethrally under direct vision. Twenty-seven patients with an average age of 67.7 years were treated between July 1991 and March 1992. At the time of evaluation 15 patients had a follow-up of more than 2 months. They experienced a mean increase of peak flow rate from 6.6 to 15.2 ml/s and a mean decrease of residual volume from 206 to 38 ml. This was accompanied by a marked lessening of symptoms. The average prostate weight decreased from 63 to 44 g. Sexually active patients did not experience retrograde ejaculation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Klinik und Poliklinik für Urologie, Ludwig-Maximilians-Universität München.
authors.forename: R
authors.initials: R
authors.lastname: Muschter
authors.forename: S
authors.initials: S
authors.lastname: Hessel
authors.forename: A
authors.initials: A
authors.lastname: Hofstetter
authors.forename: E
authors.initials: E
authors.lastname: Keiditsch
authors.forename: K H
authors.initials: KH
authors.lastname: Rothenberger
authors.forename: P
authors.initials: P
authors.lastname: Schneede
authors.forename: F
authors.initials: F
authors.lastname: Frank
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D004285:Dogs; D006801:Humans; D017075:Laser Coagulation / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000473:pathology / Q000601:surgery*; D013552:Swine; D001748:Urinary Bladder Neck Obstruction / Q000473:pathology / Q000601:surgery; D014563:Urodynamics / Q000502:physiology