Characterization and acute phase modulation of canine apolipoprotein H (beta 2-glycoprotein I).
Apolipoprotein H (ApoH) is a 50 kDa glycoprotein capable of binding to negatively charged phospholipids and is a probable inhibitor of the blood coagulation pathway, platelet aggregation, and platelet prothrombinase activity, as well as being involved in autoimmune disease. We have cloned and sequenced a full length ApoH cDNA clone from a beagle dog liver library. Its derived amino acid sequence shows high cross-species similarity to ApoH from other mammals. Canine ApoH mRNA expression is down regulated during an experimentally induced inflammatory response establishing that it is a negative acute phase reactant.
Sellar
G C
GC
Department of Genetics, Trinity Biotechnology Institute, Trinity College, Dublin, Ireland.
Keane
J
J
Mehdi
H
H
Peeples
M E
ME
Browne
N
N
Whitehead
A S
AS
D000209:Acute-Phase Proteins / Q000235:genetics / Q000378:metabolism*; D000210:Acute-Phase Reaction; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004285:Dogs; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D053482:beta 2-Glycoprotein I
D000209:Acute-Phase Proteins; D006023:Glycoproteins; D012333:RNA, Messenger; D053482:beta 2-Glycoprotein I; D004247:DNA