Chronic myelomonocytic leukemia associated with primary amyloidosis.
A case of chronic myelomonocytic leukemia (CMML) associated with primary amyloidosis (AL) is presented. Hepatosplenomegaly, macroglossia, and xanthelasma were the major physical findings. Laboratory tests showed macrocytic anemia, thrombocytopenia, monocytosis and a bi-clonal gammopathy. Early monocytes and monoblasts were noted in the bone marrow aspiration biopsy. Cytogenetic evaluation showed a clonal deletion of chromosome 21 long arm (21q-). Amyloid was present in the liver, tongue and xanthelasma. In addition, the patient was noted to have osteosclerosis of the lower extremities. Treatment with prednisone and colchicine resulted in a subjective response. The unusual association of CMML, and primary amyloidosis is discussed.
Cohen
A M
AM
Hematology Unit, Golda Medical Center, Petah-Tikva, Israel.
Mittelman
M
M
Gal
R
R
Halperin
M
M
Djaldetti
M
M
D000328:Adult; D000686:Amyloidosis / Q000150:complications* / Q000235:genetics; D002872:Chromosome Deletion; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications* / Q000235:genetics