title: Effects of intravenous digoxin on pulmonary venous and transmitral flows in patients with chronic heart failure of different degrees.
abstract: Acute effects of digoxin on diastole were evaluated noninvasively by combining data simultaneously obtained by Doppler echocardiograms (echo-Doppler) of transmitral and pulmonary venous flow curves in 38 patients with dilated and failing hearts, who had been stable for at least 7 days before the study. According to the resting ejection fraction (EF), patients were subdivided into Group 1 (EF < 30%: n = 20, mean EF values 23 +/- 8%) and Group 2 (EF > or = 30%: n = 18, mean EF values 40 +/- 3%). Significant differences were observed at rest between the two groups in both transmitral (shorter deceleration time and isovolumic relaxation time and increased peak E and E/A ratio in Group 1 vs. Group 2) and transpulmonary (reduced systolic forward component and systolic fraction of the flow curves in Group 1 compared with Group 2 and control subjects) parameters. Digoxin (1 mg subdivided into two doses, each infused over a 15-min period with 2 h between the doses) significantly modified the diastolic profile in Group 1 patients in the absence of statistically relevant changes in EF: a significant decrease of transmitral peak E (from 76 +/- 17 to 60 +/- 15 cm/s, p < 0.05) and E/A ratio (from 2.5 +/- 1 to 1.6 +/- 0.6; p < 0.05) and a significant lengthening of deceleration time (from 115 +/- 20 to 160 +/- 18 ms; p < 0.05) were detected.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: I Clinica Medica, Università degli Studi Federico II, Napoli, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giunta
authors.forename: S
authors.initials: S
authors.lastname: Maione
authors.forename: M R
authors.initials: MR
authors.lastname: Arnese
authors.forename: A
authors.initials: A
authors.lastname: Giacummo
authors.forename: G A
authors.initials: GA
authors.lastname: Liucci
authors.forename: M
authors.initials: M
authors.lastname: Palma
authors.forename: P
authors.initials: P
authors.lastname: de Campora
authors.forename: S
authors.initials: S
authors.lastname: Cangianiello
authors.forename: M
authors.initials: M
authors.lastname: Condorelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D002908:Chronic Disease; D003971:Diastole / Q000187:drug effects*; D004077:Digoxin / Q000008:administration & dosage / Q000627:therapeutic use*; D015150:Echocardiography, Doppler; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects; D011667:Pulmonary Veins / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D004077:Digoxin