Incident cases of primary liver cancer (PLC): proposal for the use of a standardised method in case-definition.
We defined some standardised criteria for classifying incident cases of liver cancer into either Primary Liver Cancer (PLC) or Unspecified Liver Cancer (ULC), on the basis of the diagnostic procedures performed. A pilot hospital-based study (98 cases) was carried out in Verona, northern Italy, in order to assess the feasibility of the method. The same protocol was subsequently applied in a population-based study (349 cases) in Bresica, northern Italy. The percentage of cases with histological verification was 38.7 and 41.8%, respectively, with a wide variation among different hospitals. The percentage of cases we attributed to the PLC category was 78.6% in the hospital-based study and 78.8% in the population-based study. No differences in the proportion of cases attributed to PLC were found according to patients' age, sex or hospital of admission. Repeatability of the method was assessed through a cross-panel review of 198 cases, with a 91.9% interobserver agreement. Implications of this method are discussed and some suggestions for cancer registration and future research are proposed.
Rodella
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Istituto Anatomia Patologica, Università di Verona, Italy.
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Fiore Donati
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Nardi
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D000368:Aged; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D010865:Pilot Projects