[Behavior of plasma proteins and nitrogen balance in patients with acute myocardial infarct with and without intravenous amino acid administration].
OBJECTIVE
The goal of this study was to examine the behaviour of nitrogen balance and plasma proteins with or without intravenous supply of amino acids in patients with acute myocardial infarction.


METHODS
30 consecutive patients who suffered from acute myocardial infarction and who were admitted to our medical intensive care unit were examined in an open, non-randomised study.


METHODS
The first 10 patients (group I) received 10% Intrafusin 10 ml/kg BW/24 h as a continuous intravenous infusion over a period of 96 h. Patients No. 11-20 (group II) received Aminosteril 10% 10 ml/kg BW/24 h also over a 96-hour period. Patients No. 21-30 (group III) were given intravenous infusions of Jonosteril 10 ml/kg BW/24 h for 96 h.


RESULTS
The nitrogen balance demonstrated a statistically significant decrease in all groups (group I, 9.1 to 6.1 g/day; group II, 9.8 to 4.8 g/day; group III, 1.3 to -1.1 g/day); however, in groups I and II the nitrogen balance remained positive. The concentrations of total protein, transferrin, retinol-binding protein and pre-albumin decreased significantly. This decrease, however, was significantly less in patients given amino acid infusions.


CONCLUSIONS
Infusion of amino acids in acute myocardial infarction results in a positive nitrogen balance and reduces the decrease in plasma protein concentrations. Further studies are required to judge the positive nutritive effect of amino acid infusions on the outcome of myocardial infarction.
Bodmann
K F
KF
Medizinische Klinik I, Städtisches Krankenhaus Hildesheim, Lehrkrankenhaus der Medizinischen Hochschule Hannover, Hildesheim.
Schuster
H P
HP
Jürgens
P
P
Tröster
S
S
D000209:Acute-Phase Proteins / Q000378:metabolism; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003422:Critical Care; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000628:therapy*; D009584:Nitrogen / Q000097:blood*; D010289:Parenteral Nutrition, Total
D000209:Acute-Phase Proteins; D000596:Amino Acids; D001786:Blood Glucose; D001798:Blood Proteins; D003404:Creatinine; D007501:Iron; D009584:Nitrogen