title: Sinus histiocytosis (Rosai-Dorfman disease) clinically limited to the skin. An immunohistochemical and ultrastructural study.
abstract: A case study of sinus histiocytosis of Rosai-Dorfman (SH) clinically limited to the skin is presented with immunohistochemical study of the infiltrate, in both paraffin and cryostat sections. Factor XIIIa, a dendrocyte marker, was demonstrated in the cytoplasm of histiocytes. This feature had not been previously reported in this disease. In addition, the cells expressed S100 protein, CD4, CD1a, CD68, and CD11c. This immunophenotyping study suggests that SH could affect the antigen-presenting activity of Factor XIIIa cells, i.e., the skin dermal dendrocyte.
authors.affiliation: Department of Pathology, University of Nice, France.
authors.forename: C
authors.initials: C
authors.lastname: Perrin
authors.forename: J F
authors.initials: JF
authors.lastname: Michiels
authors.forename: J P
authors.initials: JP
authors.lastname: Lacour
authors.forename: A
authors.initials: A
authors.lastname: Chagnon
authors.forename: J G
authors.initials: JG
authors.lastname: Fuzibet
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D018845:CD11 Antigens; D015704:CD4 Antigens / Q000032:analysis; D006644:Histiocytes / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology; D011503:Transglutaminases / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; D015214:Antigens, Differentiation, Myelomonocytic; D018845:CD11 Antigens; D015704:CD4 Antigens; D011503:Transglutaminases; C067980:CD68 antigen, human; D000097382:CD68 Molecule