Effect of dissolution profile and (-)-alpha-bisabolol on the gastrotoxicity of acetylsalicylic acid.
The effect of particle size and (-)-alpha-bisabolol on the gastric toxicity produced by acetylsalicylic acid (AAS) was studied in rats. AAS crystals of size 0.5-0.4, 0.2-0.05 mm and AAS pellets were administered orally (dose 200 mg/kg) to rats. The effect of particle size on gastric toxicity was not significant (P < 0.05). Small AAS crystals (0.2-0.05 mm) were granulated with ethanol to produce pellets (0.5-0.4 mm). The resultant pellets were less ulcerogenic than AAS crystals (P < 0.05). The pelletization process improves the wetting process of AAS crystals and for this reason produces a faster dissolution profile of AAS. When (-)-alpha-bisabolol, a natural essential oil obtained from camomile oil, was administered orally (dose 0.8-80 mg/kg) with AAS (dose 200 mg/kg), a significant (P < 0.05) protective effect was found. Some possible mechanisms of protection are suggested for (-)-alpha-bisabolol.
Torrado
S
S
Department of Pharmaceutical Technology, Faculty of Pharmacy, Complutense University and Hospital La Paz, Madrid, Spain.
Torrado
S
S
Agis
A
A
Jimenez
M E
ME
Cadórniga
R
R
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity*; D002626:Chemistry, Pharmaceutical; D005753:Gastric Mucosa / Q000473:pathology; D008297:Male; D000081222:Monocyclic Sesquiterpenes; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000494:pharmacology*; D012995:Solubility; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology
D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C004497:bisabolol; D001241:Aspirin