[Oncology of the hypertrophic prostate and study of the histogenesis of carcinoma. Histological analysis of 286 prostates obtained using the suprapubic route and examined using macro-sections including the entire visceral surface using the step-section technique].
Oncology of the hypertrophic prostate and histogenesis of the cancer. Histological examine of 286 hypertrophic prostates collected by suprapubic way, on histologic macrosections including the whole visceral area, with the "step section technique". N. 286 hypertrophic prostates collected through suprapubic way have been examined on histologic macrosections including the whole visceral area, with the step section technique. There have been used object holders slides measuring cm. 12 x 9 and cover objects measuring cm. 5 x 7. Colourings: hematoxylin-eosin , Goldner. Localisation of the tumours has been determined in the prostate area. The cases with the presence of tumours-microcarcinoma (MCP), with maximum axis up to 1 millimeter; small carcinoma (PCP), maximum axis from mm. 1.1 to mm. 5, and the classic carcinoma (CPcl) have been 232 (81%). CPcl appeared in 33 cases (11.53%). Histogenesis of the MCP has been ascertained (from terminal secretory micro-ducts of the prostate). Of PCP (from groups of MCP n. 56 in picture 7), and of CPcl (from PCP in progressive growth) or from grouping of MCP (in picture 14, 101 MCP of the 235 present in the area of mm2 40). CPcl has shows invading growth in ten cases; in 23 cases it consisted in infiltrating growth but limited, the border towards the prostatic tissue appears circumscribed by pseudocapsule, the cells show nucleoli of varying sizes. In seven cases it turned out to be adenocarcinoma with limited growth as said before, partly with pseudocapsules, and the cells appear seriously atypical, hypertrophic, hyperstained nuclei, thickening of the nuclear membrane, prominent nucleoli, in the absence of any invading tendency. Specific oncogenic agents are thought to transform the prostate cells into definite morphologic malignancy, while another oncogenic agent causes the invading proliferation.
Linoli
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Unità Operativa di Anatomia e Istologia Patologica e di Citogenetica, USL 23, Arezzo.
D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D002278:Carcinoma in Situ / Q000150:complications / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D015994:Incidence; D008297:Male; D008867:Microtomy / Q000379:methods; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D013194:Staining and Labeling