title: Structural and electronic conditions for anticonvulsant activity of bicyclic hydantoin derivatives.
abstract: A series of bicyclic derivatives based on 5,5-diphenylhydantoin (DPH) and/or 5-arylidene-hydantoin skeletons (BZH) are discussed as potential anticonvulsants. In preliminary pharmacological tests a few of these agents showed some anticonvulsant activities, like the parent DPH. The electronic parameters (molecular electrostatic potential, MEP, and dipole moment orientation) for the DPH molecule used as a model differed significantly from those calculated for the bicyclic molecules. These parameters were derived from semiempirical quantum chemistry calculations applying the PM3 method.
authors.affiliation: Institute of General and Ecological Chemistry, Technical University, Lodź, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Karolak-Wojciechowska
authors.forename: W
authors.initials: W
authors.lastname: Kwiatkowski
authors.forename: K
authors.initials: K
authors.lastname: Kiec-Kononowicz
mesh_terms: D000927:Anticonvulsants / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004597:Electroshock; D006827:Hydantoins / Q000737:chemistry*; D010433:Pentylenetetrazole; D010672:Phenytoin / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D006827:Hydantoins; D010672:Phenytoin; D010433:Pentylenetetrazole