title: Longitudinal study of cerebral blood flow following early or delayed surgery for ruptured intracranial aneurysms.
abstract: Out of a series of 43 cases operated on for ruptured intracranial aneurysms over a 12-month-period, 32 patients were followed up to 12 months postoperatively with repeated evaluations of cerebral blood flow, using the Xenon133 inhalation technique. No statistically significant differences in cerebral perfusion were detected between the subgroups of good-grade patients, who were submitted respectively to early, or delayed surgery. Depression of flow in the affected hemisphere of poor-grade patients was principally related to the preoperative occurrence of an intracerebral haematoma. The overall results were not consistent with the hypothesis that early surgical intervention results in long-lasting effects on the cerebral circulation.
authors.affiliation: Department of Neurosurgery, University of Genoa Medical School, Italy.
authors.forename: G L
authors.initials: GL
authors.lastname: Viale
authors.forename: E V
authors.initials: EV
authors.lastname: Sehrbundt
authors.forename: M
authors.initials: M
authors.lastname: Cossu
authors.forename: C
authors.initials: C
authors.lastname: Viola
authors.forename: G
authors.initials: G
authors.lastname: Rodriguez
authors.forename: A
authors.initials: A
authors.lastname: Pau
authors.forename: C
authors.initials: C
authors.lastname: Bernucci
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000503:physiopathology / Q000601:surgery*; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology / Q000601:surgery*; D002546:Ischemic Attack, Transient / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes