[Studies on the in vitro antifungal activity of lanoconazole, a new topical antimycotic, against Trichophyton spp].
In vitro studies with a new imidazole antifungal agent lanoconazole (LCZ) were carried out to confirm its fungicidal property of the anti-dermatophytic activity and unlikeliness of dermatophytes to acquire secondary resistance to this drug. Minimal cidal concentration (MCC) values of LCZ against 6 strains each of Trichophyton mentagrophytes and T. rubrum determined by the cellophane membrane method were in a range of 0.063 to 0.5 micrograms/ml, and much lower than those of bifonazole (16-32 micrograms/ml). The LCZ-sensitivity of both of the two testing strains of T. mentagrophytes did not decrease to less than one-fourth of the initial level during 15 subcultures on LCZ-containing agar. These results suggest that LCZ potently inhibits dermatophytes in a fungicidal manner and that secondary resistance to LCZ is not easily developed in the dermatophytes tested.
Niwano
Y
Y
Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd.
Kanai
K
K
Hamaguchi
H
H
Uchida
K
K
Yamaguchi
H
H
D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D014249:Trichophyton / Q000187:drug effects*
D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D007093:Imidazoles; C072774:latoconazole