[Effects of Paeonia-glycyrrhiza decoction on changes induced by cisplatin in rats].
In order to study the effects of Paeonia-Glycyrrhiza decoction (PGD) on the changes induced by cisplatin in rats, platinum-wire bipolar electrodes were inserted into the serosal membrane of the small intestine and migrating myoelectric complex (MMC) was used as index. After intravenous injection of cisplatin at doses of 4 mg/kg, the duration of the MMC cycles was significantly shorter than that of normal MMC cycles (P < 0.05) while the duration of phase III was remarkably prolonged comparing with that of normal phase III (P < 0.01) with latent period of 53.2 +/- 20.4 minutes. Taking PGD orally, cisplatin no longer induced the changes of MMC. The results suggest that PGD has marked adjusting effects on the changes of MMC induced by cisplatin. This might be one of the causes of PGD in relieving diarrhea induced by cisplatin in rats.
Xu
J D
JD
Dept. of Physiology, Chengde Medical College, Hebei.
Liu
Z H
ZH
Chen
S Z
SZ
D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006035:Glycyrrhiza; D007421:Intestine, Small / Q000503:physiopathology; D008297:Male; D009130:Muscle, Smooth / Q000503:physiopathology; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D002945:Cisplatin