Effect of noise stress and ethanol intake on hearts of spontaneously hypertensive rats.
The pathogenesis and progression of hypertensive heart disease are unclear; however, both involve a genetic predisposition and environmental influences. To test the role of exogenous factors, we examined the hearts of spontaneously hypertensive rats (SHR) exposed to noise stress and ethanol intake. Twenty-two SHR and nine normotensive Wistar rats (NWR) were continuously exposed to a 65 db, 4 and 250 Hz tone for 52 weeks. Twelve of these SHR aged 20-22 weeks were concomitantly given 20% ethanol in their drinking water up to week 52. Eight SHR and 12 NWR served as controls. We examined hemodynamic parameters, the cardiac configuration, the cardiac microvasculature, interstitial tissue, and ischemic myocardial lesions. We found that noise stress significantly increased the microvessel wall area, the number of microvessels with an outer diameter > 19 microns, the degree of cardiac fibrosis, and the extent of ischemic myocardial lesions in SHR, but not in NWR. These effects were all ameliorated and the diastolic blood pressure was lowered by the ingestion of ethanol. Cardiac weights and dimensions, heart rate and dp/dtmax were not influenced by either noise or ethanol intake. These results suggest that hypertensive heart disease in SHR can be aggravated by noise stress. Ethanol ameliorates these changes by mechanisms which remain to be explored.
Herrmann
H J
HJ
Max Delbrück Center for Molecular Medicine, Rudolph Virchow University Hospital, Free University of Berlin.
Rohde
H G
HG
Schulze
W
W
Eichhorn
C
C
Luft
F C
FC
D000818:Animals; D003331:Coronary Vessels / Q000473:pathology*; D000431:Ethanol / Q000008:administration & dosage*; D006439:Hemodynamics; D006973:Hypertension / Q000473:pathology*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D009622:Noise; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D013997:Time Factors
D000431:Ethanol