Nitric oxide is a major mediator in reactive hyperaemia evoked by a brief coronary occlusion in the guinea pig heart.
In the isolated perfused guinea pig heart coronary occlusion lasting 1-5 s is followed by reactive hyperaemia which is inhibited by 91-100% after pretreatment with a NO synthase inhibitor, NG-nitro-L-arginine (100 microM). Neither indomethacin (5 microM) nor 8-phenyltheophylline (10 microM) influences these responses. Therefore, the brief cardiac reactive hyperaemia seems to be predominantly if not entirely mediated by nitric oxide (NO).
Chłopicki
S
S
Department of Pharmacology, N. Copernicus University School of Medicine, Kraków, Poland.
Gryglewski
R J
RJ
D000109:Acetylcholine / Q000494:pharmacology; D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003331:Coronary Vessels / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D006940:Hyperemia / Q000503:physiopathology*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000187:drug effects; D017725:Ventricular Pressure / Q000187:drug effects
D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine; D013806:Theophylline; C028322:8-phenyltheophylline; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D000109:Acetylcholine; D007213:Indomethacin