Effect of flunixin meglumine on the thresholds to mechanical stimulation in healthy and lame sheep.
The antinociceptive effect of flunixin meglumine was assessed in healthy and lame sheep by using a noxious mechanical stimulus. Sheep suffering from the chronically painful condition, footrot, have previously been shown to have lower thresholds to noxious mechanical stimuli than healthy animals. In the present study, 22 sheep suffering from footrot did not have a lower mean mechanical threshold than 25 matched healthy animals, but it was significantly greater than that recorded from eight experimental sheep (5.0 [2.5], 4.9 [2.1] and 3.0 [1.0] Newtons, respectively). Doses of 1.0 or 2.0 mg kg-1 of flunixin meglumine had no effect on the thresholds to noxious mechanical stimulation in either experimental sheep tested over six hours, or in lame sheep tested over a period of 30 minutes. The repeated administration of flunixin to sheep suffering from footrot over a period of three days reduced their thresholds to noxious mechanical stimulation.
Welsh
E M
EM
Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden.
Nolan
A M
AM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003002:Clonixin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005535:Foot Rot / Q000503:physiopathology*; D007794:Lameness, Animal / Q000503:physiopathology; D008297:Male; D017288:Pain Threshold / Q000187:drug effects*; D010812:Physical Stimulation; D012756:Sheep / Q000502:physiology*; D012757:Sheep Diseases / Q000503:physiopathology*; D013223:Statistics as Topic
D000894:Anti-Inflammatory Agents, Non-Steroidal; C014558:flunixin meglumine; D003002:Clonixin