Clinical manifestations and risk factors of Pseudomonas aeruginosa infection in patients with AIDS.
Fifty-eight patients with human immunodeficiency virus infection were analyzed for clinical manifestations and potential risk factors for Pseudomonas aeruginosa infection by use of case-control methodology. Most had AIDS. Of 73 episodes of P. aeruginosa infection, 45 (62%) were bacteremias primarily associated with central venous catheters (16), pneumonia (12), soft tissue (4), or urinary tract infections (4). Twenty-eight episodes (38%) were nonbacteremic, with pneumonia (13), soft tissue infections (6), and sinusitis (4) accounting for the majority of infections. Fifty episodes (68%) were community-acquired. The recurrence rate was 23%. The overall mortality attributable to P. aeruginosa infection was 22%. Central venous and urinary catheter use and steroid therapy were significantly more frequent in cases than controls (P < .05). Thus, P. aeruginosa infection in patients with advanced human immunodeficiency virus disease is often community-acquired and associated with substantial mortality and, in some cases, specific risk factors.
Dropulic
L K
LK
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196.
Leslie
J M
JM
Eldred
L J
LJ
Zenilman
J
J
Sears
C L
CL
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology; D016022:Case-Control Studies; D002405:Catheterization, Central Venous; D017714:Community-Acquired Infections; D005260:Female; D015658:HIV Infections / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000209:etiology; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D013256:Steroids / Q000627:therapeutic use; D014546:Urinary Catheterization
D000900:Anti-Bacterial Agents; D013256:Steroids