IgG-kappa-type plasmacytoma secreting salivary-type amylase in adult T-cell leukemia.
A IgG-kappa-type plasmacytoma secreting salivary-type amylase ectopically is reported in a patient with smouldering adult T-cell leukemia(ATL). The patient had plasmacytomas in the distal region of the right femur, the proximal region of left tibia, and the left paranasal sinus. Both his serum and urine contained high levels of amylase. The presence of IgG-kappa and S-type amylase in the plasmacytoma cells was confirmed immunocytochemically. In addition, he was also positive for the antibody against the human T-cell leukemia virus type I (HTLV-I), and had abnormal lymphocytes with convoluted nuclei (ATL cells) in the peripheral blood. The monoclonal integration of HTLV-I proviral DNA was demonstrated in the leukemic cells of the peripheral blood, but not in the plasmacytoma cells. Our case suggested that not only can HTLV-I infection play a role in the development of ATL, but may also induce a B-cell malignancy in an indirect manner, and even an ectopic amylase producing plasmacytoma.
Shimamoto
Y
Y
Department of Internal Medicine, Saga Medical School, Japan.
Tominaga
H
H
Sano
M
M
Takeya
M
M
Yamaguchi
M
M
D000681:Amylases / Q000032:analysis / Q000096:biosynthesis*; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D015458:Leukemia, T-Cell / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000150:complications* / Q000201:enzymology* / Q000276:immunology / Q000382:microbiology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007145:Immunoglobulin kappa-Chains; D000681:Amylases