title: Synergistic effect of oral UFT in combination with cisplatin on DNA synthesis in rat hepatocarcinomas.
abstract: We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and, moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.
authors.affiliation: Medical Research Institute, Tokyo Medical and Dental University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Taga
authors.forename: T
authors.initials: T
authors.lastname: Uchikoshi
authors.forename: H
authors.initials: H
authors.lastname: Kudo
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Sugiura
authors.forename: K
authors.initials: K
authors.lastname: Kuwa
authors.forename: Y
authors.initials: Y
authors.lastname: Endo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects*; D004357:Drug Synergism; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008749:Methyldimethylaminoazobenzene; D051381:Rats; D013937:Thymidine Kinase / Q000096:biosynthesis*; D013940:Thymidylate Synthase / Q000096:biosynthesis*; D014498:Uracil / Q000008:administration & dosage / Q000494:pharmacology*; D000509:alpha-Fetoproteins / Q000096:biosynthesis
chemical_list: D004273:DNA, Neoplasm; D000509:alpha-Fetoproteins; D008749:Methyldimethylaminoazobenzene; D014498:Uracil; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D002945:Cisplatin