title: Involvement of capsaicin-sensitive afferent nerves in the intestinal motor alterations induced by intestinal anaphylaxis in rats.
abstract: Alteration of intestinal myoelectrical activity is a characteristic feature of food protein-induced intestinal anaphylaxis in the conscious rat. The motility changes induced by antigen challenge were appraised in egg-albumin-sensitized rats, chronically implanted with NiCr electrodes in the duodenojejunal wall. Intraduodenal infusion of egg albumin given to fasted sensitized rats triggered a disruption of the cyclic pattern of small intestinal motility lasting 79.1 +/- 23.3 min. The duration of the challenge effect on intestinal myoelectrical activity was significantly reduced by systemic capsaicin pretreatment (125 mg/kg) but to a lesser extent by perivagal capsaicin. Substance P (SP) antagonists (SP 4-11 and CP 96.345) and atropine were also able to shorten the duration of the antigen-challenge-induced alteration of intestinal motility. It is concluded that SP and capsaicin-sensitive afferent nerve endings play an important role in the intestinal anaphylaxis-induced disturbances of intestinal motility.
authors.affiliation: Department of Pharmacology, INRA, Toulouse, France.
authors.forename: M J
authors.initials: MJ
authors.lastname: Fargeas
authors.forename: J
authors.initials: J
authors.lastname: Fioramonti
authors.forename: L
authors.initials: L
authors.lastname: Bueno
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology*; D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology*; D004576:Electromyography; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D007421:Intestine, Small / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D009130:Muscle, Smooth / Q000187:drug effects; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D013373:Substance P / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D001713:Biphenyl Compounds; C081680:substance P (4-11), Pro(4)-Trp(2,9,10)-; D013373:Substance P; D001285:Atropine; D010047:Ovalbumin; D002211:Capsaicin; C066892:CP 96345