Anti-fertility activity and hormonal profile of trans-anethole in rats.
Trans-anethole was studied for antifertility activity in rats at dose levels of 50 mg, 70 mg and 80 mg/kg po. Dose-dependent activity was observed, a 100% anti-implantation activity being achieved at 80 mg/kg, po. The compound showed a significant estrogenic activity and did not possess anti-estrogenic, progestational, anti-progestational, androgenic or anti-androgenic activities. In an earlier study, the compound was found to be safe, its LD50 being more than 3000 mg/kg, po in mice.
Dhar
S K
SK
Pharmacology Division, Regional Research Laboratory, Jammu Tawi.
D000028:Abortion, Induced; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000494:pharmacology* / Q000633:toxicity; D003276:Contraceptives, Oral / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D011247:Pregnancy; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D003276:Contraceptives, Oral; D004967:Estrogens; D013739:Testosterone; D004958:Estradiol; C006578:anethole