Granulocyte colony stimulating factor (G-CSF) for mustard-induced bone marrow suppression.
The authors describe the development of a clinical protocol to treat mustard gas-induced myelosuppression with granulocyte colony stimulating factor (G-CSF), a hematopoietic growth factor. Limited clinical evidence suggests a significant role for mustard gas-induced myelosuppression in the overall morbidity of mustard gas victims. Initial data from primates revealed that G-CSF could ameliorate neutropenia following nitrogen mustard exposure. Exploiting the extensive oncologic experience with G-CSF, which demonstrated its safety and absence of serious side effects the authors developed a clinical protocol for use of this drug in potential mustard gas victims in the Persian Gulf conflict.
Meisenberg
B R
BR
Department of Internal Medicine (Hematology/Oncology Division), Naval Hospital, San Diego, CA 92134-5000.
Melaragno
A J
AJ
Monroy
R L
RL
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002985:Clinical Protocols; D004195:Disease Models, Animal; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007493:Iraq; D008253:Macaca mulatta; D008297:Male; D008466:Mechlorethamine / Q000506:poisoning*; D008887:Military Medicine; D009503:Neutropenia / Q000139:chemically induced / Q000517:prevention & control; D010198:Pancytopenia / Q000139:chemically induced; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D014481:United States; D014857:Warfare
D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor; D008466:Mechlorethamine