Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24.
The sequence of the exon 1/intron 1 boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8;14) (q24;q32) and the other with t(8;22) (q24;q11). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding site in intron 1, which is a frequent target for mutational inactivation in endemic Burkitt's lymphoma (eBL). The translocations at 8q24, and multiple mutations in the exon 1/intron 1 boundary region, are reminiscent of similar findings in eBL. The same underlying oncogenic event that occurs in most eBLs is thus found in some DLCLs.
Bradley
J F
JF
Molecular Genetics Laboratory, Children's Mercy Hospital, Kansas City, MO 64108.
Rothberg
P G
PG
Ladanyi
M
M
Chaganti
R S
RS
D001483:Base Sequence; D002898:Chromosomes, Human, Pair 8; D016259:Genes, myc; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D014178:Translocation, Genetic
D009838:Oligodeoxyribonucleotides