The mutator mut7-1 of Saccharomyces cerevisiae.
The mut7-1 mutant of Saccharomyces cerevisiae is a cell-division-cycle mutant, exhibiting temperature-sensitive lethality and enhancement of mutator activity with increases in temperature. The base-sequence alterations in mutants arising in a mut7-1 background differed from the control by there being a higher transversion/transition ratio and by the much increased production of multi-base deletions. The deletions were, in every instance, associated with repeated oligonucleotide sequences (3-8 bases in length), where one of the two sequences was removed during the deletion process. The mutant mut7-1 failed to complement with cdc2, the temperature-sensitive mutant of the locus which encodes DNA polymerase III (delta).
von Borstel
R C
RC
Department of Genetics, University of Alberta, Edmonton, Canada.
Ord
R W
RW
Stewart
S P
SP
Ritzel
R G
RG
Lee
G S
GS
Hennig
U G
UG
Savage
E A
EA
D001483:Base Sequence; D002455:Cell Division; D005784:Gene Amplification; D005838:Genotype; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013696:Temperature