title: Effects of chlordecone and malnutrition on immune response in rats.
abstract: Effect of Chlordecone (Cd) and malnutrition on total body and spleen weights, and plaque forming cells (PFC) were studied. Rats were fed on normal, calcium (Ca-D), protein (P-D) or Ca+P-deficient diets containing 0, 10 or 100 ppm of Cd for 2 or 4 weeks. High (95-100%) mortality was observed in malnourished rats treated with 100 ppm of Cd for 4 weeks. A slight decrease in body weight and an increase in spleen weight was observed in normal but not malnourished rats treated with 10 ppm of Cd for 4 weeks. PFC were significantly increased in both malnourished and Cd-treated rats. Similar increase in PFC was observed in rats fed on Ca-D but not P-D diet containing 10 or 100 ppm of Cd. Whereas, rats fed on Ca+P-D diet containing 100 ppm of Cd exhibited a significant decrease in PFC.
authors.affiliation: Department of Biological Sciences, Grambling State University, Louisiana 71245.
authors.forename: K N
authors.initials: KN
authors.lastname: Chetty
authors.forename: K
authors.initials: K
authors.lastname: Brown
authors.forename: J
authors.initials: J
authors.lastname: Walker
authors.forename: L
authors.initials: L
authors.lastname: Woods
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000172:deficiency; D007631:Chlordecone / Q000633:toxicity*; D006462:Hemolytic Plaque Technique; D008297:Male; D009748:Nutrition Disorders / Q000276:immunology / Q000503:physiopathology*; D009929:Organ Size / Q000187:drug effects; D011488:Protein Deficiency / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000033:anatomy & histology / Q000187:drug effects / Q000276:immunology
chemical_list: D007631:Chlordecone; D002118:Calcium