title: Crude drugs from aquatic plants. V. On the constituents of alismatis rhizoma. (3). Stereostructures of water-soluble bioactive sesquiterpenes, sulfoorientalols a, b, c, and d, from Chinese alismatis rhizoma.
abstract: From the water-soluble portion of Chinese Alismatis Rhizoma, four bioactive sesquiterpenes, sulfoorientalols a, b, c, and d, were isolated and their structures having a sulfonic acid function were established on the basis of chemical and physicochemical evidence. In addition, two sulfoorientalol congeners were derived from alismol by sulfonation of the exo-methylene moiety. Sulfoorientalols and the synthetic congeners were found to inhibit the carbachol-induced contraction of isolated bladder smooth muscle of guinea pig.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Yamahara
authors.forename: N
authors.initials: N
authors.lastname: Murakami
mesh_terms: D000818:Animals; D002217:Carbachol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009130:Muscle, Smooth / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D013438:Sulfhydryl Compounds; D002217:Carbachol