title: Role of local pancreatic blood flow in development of hemorrhagic pancreatitis induced by stress in rats.
abstract: Our previous data showed that the pancreatitis induced in rats by cerulein develops into hemorrhagic pancreatitis following water-immersion stress. The present study examined the effects of water-immersion stress and high doses of cerulein (intraperitoneal injection) on pancreatic blood flow. Five hours of water-immersion stress reduced the local pancreatic blood flow to approximately 30% of the initial value (253.75 +/- 12.58 ml/min/100 g) without causing any histological alterations. Blood flow was decreased as early as 1 h after the immersion and reached the lowest value (30% of initial value) 3 h after the immersion. The administration of 40 micrograms/kg body wt cerulein as two intraperitoneal injections reduced the pancreatic blood flow by 40% 5 h after the first cerulein injection. The injections of cerulein combined with water-immersion stress did not reduce the pancreatic blood flow more than did water-immersion stress alone. The systemic blood pressure was unaffected during 5 h of water immersion after the cerulein injections. These findings suggest that in rats the stress-induced decrease of local pancreatic blood flow may not produce pancreatitis, but may aggravate an existing acute pancreatitis.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Sumii
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Nawata
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D002196:Capillaries / Q000473:pathology; D004298:Dopamine / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000473:pathology; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009929:Organ Size / Q000502:physiology; D010179:Pancreas / Q000098:blood supply* / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology*; D013927:Thrombosis / Q000209:etiology / Q000473:pathology; D014667:Vasopressins / Q000494:pharmacology
chemical_list: D014667:Vasopressins; D000681:Amylases; D004298:Dopamine