[The modifications of mutagenesis and anticarcinogenesis].
The problems of anticarcinogenesis are discussed in the context of mechanistic approaches and the well-known mechanisms of multistage carcinogenesis. Various events at extra- and intracellular levels are involved in mutagenesis and carcinogenesis. The most promising candidates for suppression of chemical carcinogenesis are some nitrosation modifiers, dietary sorbents, metabolic activation modulators, reactive metabolite trappers, repair inducers, gene expression inhibitors, etc. Short-term tests for mutagenicity are more preferable for screening potential anticarcinogenic agents. The bioassays for anticarcinogenesis should be assessed for sensitivity, specificity and predictability and the genetic profiles of the antimutagenic activity of the modifiers analysed.
Khudoleĭ
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D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000494:pharmacology; D015197:Carcinogenicity Tests; D004247:DNA / Q000187:drug effects; D004347:Drug Interactions; D006801:Humans; D016296:Mutagenesis / Q000187:drug effects* / Q000235:genetics; D009152:Mutagenicity Tests; D009154:Mutation; D009369:Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000517:prevention & control; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000235:genetics / Q000517:prevention & control
D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D004247:DNA