Role of calcium in biphasic immunomodulation by gamma-HCH (lindane) in mice.
gamma-HCH (Lindane) is reported to cause a biphasic immunomodulation-stimulation followed by suppression-after oral administration in mice. Role of calcium in this biphasic immunomodulation was assessed after 4, 12 and 24 wks of gamma-HCH administration. 45Ca-uptake was enhanced during the initial immunostimulation followed by decrease concomitant with immunosuppression. Lymphocyte proliferation was inhibited during both the phases of immune response by verapamil, a calcium channel blocker, and by trifluoperazine, a calmodulin inhibitor. These findings show an impairment of calcium homeostasis in lymphocytes culminating into the biphasic immunomodulatory effects of gamma-HCH.
Meera
P
P
Division of Physiology, Central Drug Research Institute, Lucknow, India.
Tripathi
O
O
Kamboj
K K
KK
Rao
P R
PR
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000187:drug effects; D002147:Calmodulin / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D014268:Trifluoperazine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D015220:Calcium Channels; D002147:Calmodulin; D007166:Immunosuppressive Agents; D014268:Trifluoperazine; D001556:Hexachlorocyclohexane; D014700:Verapamil; D002118:Calcium