Atrial natriuretic peptide and bradykinin interaction on norepinephrine uptake in rat adrenal medulla.
Interactions between atrial natriuretic peptide (ANP) and bradykinin (BDK) on norepinephrine (NE) uptake were demonstrated in the adrenal medulla of the rat. One hundred nM ANP and 10 nM BDK increased total NE uptake. Subthreshold concentration of ANP (1nM) or BDK (1nM) reverted the effects of thre shold concentrations of both peptides (10 nM BDK and 100 nM ANP respectively). Effective concentrations of ANP and BDK acting simultaneously did not induce additive effects on total NE uptake. Threshold concentrations of both peptides increased neuronal NE uptake only. These results suggest interactions between ANP and BDK at the neuronal uptake level. They confirm that ANP and BDK take part in the regulation of the sympathetic activity in the adrenal medulla of the rat.
Vatta
M S
MS
Cátedra de Fisiopatología & Programa de Sistemas Vasopresores (PROSIVAD) CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Bianciotti
L G
LG
Fernandez
B E
BE
D000313:Adrenal Medulla / Q000294:innervation / Q000378:metabolism*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001920:Bradykinin / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D009320:Atrial Natriuretic Factor; D001920:Bradykinin; D009638:Norepinephrine