[A case of metastatic splenic tumor treated with intra-arterial immunochemotherapy to induce endogenous LAK cell].
The patient was an 82-year-old female with a 32-month clinical course after right hemicolectomy for ascending colon cancer. Serum carcino embryonic antigen (S-CEA) increased about 38 ng/ml, and metastatic spleen tumor was recognized by abdominal CT and MRI. To induce endogenous LAK, intra-arterial immunochemotherapy with cyclophosphamide (CPM) and OK-432 was performed. Three days after CPM administration, peripheral white blood cells decreased. Recovery from this CPM side effect was achieved with granulocyte colony-stimulating factor (G-CSF). LAK activity of peripheral blood lymphocytes increased from 3% to 17%. Then intra-arterial immunochemotherapy was continued for 7 months, after which the tumor size increased but the S-CEA level remained under 40 ng/ml.
Ogawara
T
T
First Dept. of Surgery, Yamanashi Medical College.
Sekikawa
T
T
Kouno
K
K
Matsumoto
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D007167:Immunotherapy; D007261:Infusions, Intra-Arterial; D015979:Killer Cells, Lymphokine-Activated / Q000502:physiology*; D010844:Picibanil / Q000008:administration & dosage*; D013160:Splenic Neoplasms / Q000276:immunology / Q000556:secondary / Q000628:therapy*
D002272:Carcinoembryonic Antigen; D016179:Granulocyte Colony-Stimulating Factor; D010844:Picibanil; D003520:Cyclophosphamide