[Non-A, non-B/C hepatitis].
A recombinant immunoscreening approach was used to clone and identified the genome of the non-A, non-B hepatitis virus. This agent is a positive-stranded RNA virus that appears to be distantly related to the flaviviridae family. A recombinant viral antigen (C100-3) was used to develop a "capture" assay for circulating antibody. Data obtained using this assay indicate that this agent, termed the Hepatitis C virus (HCV), is the major cause of post-transfusion, community-acquired and cryptogenic, NANB. HCV is associated with the development of hepatocellular carcinoma and possibly, other liver diseases. In this article the characteristic of Hepatitis C virus were discussed.
Durupinar
B
B
Ondokuzmayis Universitesi, Tip Fakültesi Mikrobiyoloji Anabilim Dali.
D006528:Carcinoma, Hepatocellular / Q000209:etiology; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification*; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000150:complications / Q000209:etiology / Q000382:microbiology*; D018937:Hepatitis C Antibodies; D006521:Hepatitis, Chronic / Q000382:microbiology; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology; D012307:Risk Factors; D065227:Transfusion Reaction
D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies