title: GM-CSF and G-CSF in Felty's syndrome.
abstract: The risk of infection is increased in patients with Felty's syndrome, neutropenia being one of the main reasons for the susceptibility to infection. We report the case of a 56-year-old patient with Felty's syndrome in whom successive therapy with GM-CSF, splenectomy, and G-CSF was tried because of recurrent severe infections. Therapy with GM-CSF and G-CSF resulted in improvement of neutropenia and in successful treatment of cutaneous and pulmonary infections.
authors.affiliation: Medizinische Poliklinik, Universität München.
authors.forename: D R
authors.initials: DR
authors.lastname: Wagner
authors.forename: C
authors.initials: C
authors.lastname: Combe
authors.forename: U
authors.initials: U
authors.lastname: Gresser
mesh_terms: D003131:Combined Modality Therapy; D005258:Felty Syndrome / Q000150:complications / Q000601:surgery / Q000628:therapy*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007239:Infections / Q000209:etiology; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D013156:Splenectomy
chemical_list: D007155:Immunologic Factors; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor