title: Mapping of the gene for interferon-inducible dsRNA-dependent protein kinase to chromosome region 2p21-22: a site of rearrangements in myeloproliferative disorders.
abstract: Recent evidence suggests that the human interferon-inducible double-stranded RNA-dependent protein kinase may function as a tumor suppressor. Here we describe the mapping of the gene for this kinase to chromosome region 2p21-22 by fluorescence in situ hybridization. A combined analysis of cytogenetic data from a series of 341 patients with hematologic disorders that exhibited cytogenetic abnormalities and from published reports indicates that abnormalities involving 2p21-22 occur nonrandomly and are observed among patients with acute myelogenous leukemia, raising the possibility of a role for this protein kinase in leukemogenesis.
authors.affiliation: Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor.
authors.forename: S M
authors.initials: SM
authors.lastname: Hanash
authors.forename: L
authors.initials: L
authors.lastname: Beretta
authors.forename: C L
authors.initials: CL
authors.lastname: Barcroft
authors.forename: S
authors.initials: S
authors.lastname: Sheldon
authors.forename: T W
authors.initials: TW
authors.lastname: Glover
authors.forename: D
authors.initials: D
authors.lastname: Ungar
authors.forename: N
authors.initials: N
authors.lastname: Sonenberg
mesh_terms: D001853:Bone Marrow / Q000201:enzymology / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D004790:Enzyme Induction; D005260:Female; D006402:Hematologic Diseases / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007372:Interferons / Q000494:pharmacology*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D008297:Male; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis / Q000235:genetics*; D019892:eIF-2 Kinase
chemical_list: D007372:Interferons; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase