title: A new strategy for the synthesis of polychlorinated biphenyl metabolites.
abstract: A general and high-yielding synthetic route is presented by which a variety of chlorinated dihydroxybiphenyl metabolites may be synthesized. These synthetic standards will permit the investigation of novel pathways of polychlorinated biphenyl activation. The biphenyldiols were synthesized via palladium-catalyzed cross-coupling of dimethoxyphenylboronic acids with aryl bromides in the presence of a base. The formed dimethoxybiphenyls were demethylated using boron tribromide to yield the chlorinated dihydroxybiphenyls. These compounds were characterized by IR, NMR, and GC/MS.
authors.affiliation: Graduate Center for Toxicology, University of Kentucky, Lexington 40506-0054, USA.
authors.forename: U
authors.initials: U
authors.lastname: Bauer
authors.forename: A R
authors.initials: AR
authors.lastname: Amaro
authors.forename: L W
authors.initials: LW
authors.lastname: Robertson
mesh_terms: D011078:Polychlorinated Biphenyls / Q000138:chemical synthesis / Q000378:metabolism*
chemical_list: D011078:Polychlorinated Biphenyls