An antagonist of glutamate metabotropic receptors, (RS)-alpha-methyl-4-carboxyphenylglycine, prevents the LTP-related increase in postsynaptic AMPA sensitivity in hippocampal slices.
(RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), a compound which selectively antagonizes metabotropic glutamate receptors (mGlu-R), presents the LTP of field excitatory postsynaptic potentials (fEPSP) as well as the tetanus-induced increase in AMPA-evoked responses (fPRs) in the CA1 region of hippocampal slices. This effects of MCPG provide evidence for the involvement of mGlu-Rs in mechanisms underlying the postsynaptic maintenance of LTP, which appears to be mediated, at least partially, by an increase in sensitivity and/or number of postsynaptic AMPA receptors.
Sergueeva
O A
OA
Department of Neurophysiology, Institute of Neurobiology, Magdeburg, Germany.
Fedorov
N B
NB
Reymann
K G
KG
D000818:Animals; D001565:Benzoates / Q000008:administration & dosage / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D007478:Iontophoresis; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000187:drug effects; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D001565:Benzoates; D018091:Receptors, AMPA; D018094:Receptors, Metabotropic Glutamate; C079694:alpha-methyl-4-carboxyphenylglycine; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D005998:Glycine