Carbodithioate MeOBDCG for decreasing intracellular cadmium deposits in rats of different ages.
The efficiency of chelating agents to remove aged intracellular deposits of cadmium in young and older rats was studied. The administration of the chelating agent sodium N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate monohydrate (MeOBDCG) 2 wk after a single intraperitoneal 115m Cd administration reduced the whole body, liver, and kidney retention in suckling rats to about 63, 42, and 71 percent and in older rats to 39, 17, and 76 percent of values obtained in respective controls. Chelation therapy was generally more effective in older than younger rats and the age-related effect was most pronounced in the liver. These results indicate that specific features of young organisms may significantly alter the effect of chelation treatment.
Arezina
R
R
Institute for Medical Research and Occupational Health, University of Zagreb, Croatia.
Kargacin
B
B
Kostial
K
K
Jones
M M
MM
Singh
P K
PK
D000375:Aging / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000378:metabolism; D015913:Chelation Therapy; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D051381:Rats; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013859:Thiocarbamates / Q000627:therapeutic use*
D013859:Thiocarbamates; D002104:Cadmium; C060427:N-(4-methoxybenzyl)glucamine dithiocarbamate; D013012:Sorbitol