title: Expression of the CD15 antigen in hepatocellular carcinoma.
abstract: Expression of the CD15 antigen, which is one of the adhesion molecules, was studied immunohistochemically to investigate the mechanism of intrahepatic metastasis in 56 hepatocellular carcinomas (HCC). Twenty-nine percent (16 of 56) of the HCC expressed CD15. No noncancerous hepatocytes expressed CD15. CD15-positive HCC had histologic intrahepatic metastasis more often than did CD15-negative HCC; the difference was statistically significant (P < 0.02). The survival rate of patients with CD15-negative HCC was better than that of patients with CD15-positive HCC, although the difference was not statistically significant. The authors speculate that there is a relationship between the expression of CD15 and intrahepatic metastasis in HCC.
authors.affiliation: Department of Surgery II, Nagoya University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Torii
authors.forename: A
authors.initials: A
authors.lastname: Nakayama
authors.forename: A
authors.initials: A
authors.lastname: Harada
authors.forename: A
authors.initials: A
authors.lastname: Nakao
authors.forename: T
authors.initials: T
authors.lastname: Nonami
authors.forename: J
authors.initials: J
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Takagi
mesh_terms: D015703:Antigens, CD / Q000032:analysis / Q000235:genetics*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000556:secondary / Q000601:surgery; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D015870:Gene Expression; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D016256:Lewis X Antigen; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D015996:Survival Rate
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D016256:Lewis X Antigen