title: Human papillomavirus infection is transient in young women: a population-based cohort study.
abstract: The prevalence of human papillomavirus (HPV) infection in cervical cell scrapes from a cohort of 276 young women was determined by a general two-step polymerase chain reaction. HPV infection fluctuated among young women during a 2-year interval. The total prevalence of HPV infection decreased from 21% to 8.3%. The most prevalent HPV types at enrollment were HPV-16 (3.3%) and HPV-6 (2.9%). At follow-up, the most common type was HPV-16 (2.9%), while no HPV-6 was detected. In 2 women only, the same HPV type persisted. Regression of HPV infection was found in 80% of the women. A new HPV type-specific infection was detected in 7.2% of the women and was independently associated with a new sex partner or an abnormal smear since enrollment.
authors.affiliation: Department of Virology, Umeå University, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Evander
authors.forename: K
authors.initials: K
authors.lastname: Edlund
authors.forename: A
authors.initials: A
authors.lastname: Gustafsson
authors.forename: M
authors.initials: M
authors.lastname: Jonsson
authors.forename: R
authors.initials: R
authors.lastname: Karlsson
authors.forename: E
authors.initials: E
authors.lastname: Rylander
authors.forename: G
authors.initials: G
authors.lastname: Wadell
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000821:virology; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D013548:Sweden / Q000453:epidemiology; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000821:virology; D002577:Uterine Cervical Diseases / Q000453:epidemiology* / Q000821:virology
chemical_list: D004279:DNA, Viral