Blood pressure reduction during treatment: day and night or daytime only?
PROGNOSTIC EFFECTS OF DAY-NIGHT BLOOD PRESSURE DIFFERENCE: In the vast majority of patients with hypertension, blood pressure during sleep is approximately 10-15% lower than during waking hours, but these levels are still higher than those in normotensive subjects. In some patients, the difference in blood pressure between daytime and night-time is smaller than in others, and these patients have been shown to have more severe cardiovascular complications.


CONCLUSIONS
Maintaining uniform blood pressure control over 24 h seems to be a desirable goal, which can be achieved with long-acting antihypertensive drugs administered once daily.
Pessina
A C
AC
Clinica Medica I, University of Padua, Italy.
Palatini
P
P
D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*; D013997:Time Factors
D000959:Antihypertensive Agents