title: Hepatocyte paraffin 1: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors.
abstract: Hepatocyte paraffin 1 is a monoclonal antibody that has been developed specifically to react with hepatocytes in routine formalin-fixed and paraffin-embedded surgical pathology tissues. It results in a distinct, granular cytoplasmic staining of hepatocytes but fails to react with bile ducts and nonparenchymal liver cells. The antibody decorates a majority of hepatocellular carcinomas, including fibrolamellar variants. It fails to react with a wide variety of other adult malignancies, with the exception of focal staining in a few gastrointestinal malignancies, including a subpopulation of gastric carcinomas.
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine, PA 15261.
authors.forename: A E
authors.initials: AE
authors.lastname: Wennerberg
authors.forename: M A
authors.initials: MA
authors.lastname: Nalesnik
authors.forename: W B
authors.initials: WB
authors.lastname: Coleman
mesh_terms: D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008099:Liver / Q000276:immunology* / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012189:Retrospective Studies; D013194:Staining and Labeling
chemical_list: D000911:Antibodies, Monoclonal