title: Study of tyrosine hydroxylase and neuropeptidergic innervation of the human obstructed pelveoureteral junction in four different patients.
abstract: Tyrosine hydroxylase and neuropeptidergic innervations of the obstructed pelveoureteral junctions of four different patients were investigated by immunohistochemical methods. A dense innervation of tyrosine hydroxylase- and neuropeptide Y-nerves was found especially in the pelveoureteral junction, which was congenitally obstructed, compared to others found later (13- and 23-year old females). Also quite numerous vasoactive intestinal polypeptide-nerves were seen as well as some calcitonin gene-related peptide-, galanin- and substance P-nerves in the muscular layer of ureter. The innervation pattern of the obstructed pelveoureteral junction of the horseshoe kidney was found to be normal.
authors.affiliation: Section of Urology, Tampere University Hospital, Tampere University, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Tainio
authors.forename: K
authors.initials: K
authors.lastname: Järvilehto
authors.forename: T
authors.initials: T
authors.lastname: Kylmälä
mesh_terms: D000293:Adolescent; D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis; D005260:Female; D019004:Galanin; D006801:Humans; D007223:Infant; D007682:Kidney Pelvis / Q000737:chemistry* / Q000201:enzymology / Q000294:innervation; D008297:Male; D009478:Neuropeptide Y / Q000032:analysis; D009479:Neuropeptides / Q000032:analysis*; D010455:Peptides / Q000032:analysis; D013373:Substance P / Q000032:analysis; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*; D014513:Ureter / Q000737:chemistry* / Q000201:enzymology / Q000294:innervation; D014517:Ureteral Obstruction / Q000151:congenital / Q000378:metabolism* / Q000473:pathology
chemical_list: D009478:Neuropeptide Y; D009479:Neuropeptides; D010455:Peptides; D013373:Substance P; D019004:Galanin; D014446:Tyrosine 3-Monooxygenase; D015740:Calcitonin Gene-Related Peptide