title: Effects of kidney transplantation on the renin-angiotensin systems of the recipients.
abstract: To investigate the effects of renal transplantation on the plasma and local kidney renin-angiotensin systems of the recipients the left kidneys of 13 adult male Wistar-Kyoto rats (WKY) and 13 stroke-prone spontaneously hypertensive rats (SHRSP) were transplanted to bilaterally nephrectomized (WKYxSHRSP)-F1 hybrids. Nine unilaterally nephrectomized WKY and nine SHRSP served as controls. Four weeks after surgery recipients of an SHRSP kidney but not recipients of a WKY kidney had significant post-transplantation hypertension. Plasma renin activity (PRA) was higher in SHRSP than in WKY. Transplanted rats had lower PRAs than nontransplanted controls. Plasma ACE activity was lowest in SHRSP, intermediate in transplanted F1 hybrids and highest in WKY. Plasma Ang I and Ang II concentrations closely paralleled each other. They were not significantly different between WKY and SHRSP and lower in transplanted than in nontransplanted rats. ACE and renin mRNA were lower in transplanted than in nontransplanted kidneys. Glomerular angiotensin II receptor density was higher in transplanted than in nontransplanted kidneys with no significant differences between strains. We conclude that renal transplantation has profound long-term effects on the recipients' plasma and local kidney renin-angiotensin systems. These do not appear to be involved in the pathogenesis of post-transplantation hypertension in recipients of an SHRSP kidney, but may reflect a role for the intrarenal renin-angiotensin system in long-term renal adaptation and repair processes after transplantation.
authors.affiliation: Department of Pharmacology University of Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Rettig
authors.forename: M
authors.initials: M
authors.lastname: Büch
authors.forename: R
authors.initials: R
authors.lastname: Gerstberger
authors.forename: P
authors.initials: P
authors.lastname: Schnatterbeck
authors.forename: M
authors.initials: M
authors.lastname: Paul
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000235:genetics; D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D004195:Disease Models, Animal; D006824:Hybridization, Genetic; D006973:Hypertension / Q000209:etiology; D007668:Kidney / Q000378:metabolism; D016030:Kidney Transplantation / Q000009:adverse effects / Q000502:physiology*; D008297:Male; D009392:Nephrectomy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012083:Renin / Q000097:blood / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics / Q000502:physiology*
chemical_list: D012333:RNA, Messenger; D000808:Angiotensinogen; D000804:Angiotensin II; D000803:Angiotensin I; D000110:Acetylcholinesterase; D012083:Renin