The RIA for IGFBP-2 in man--a meagre catch?
In man IGFBP-2 is by concentration the second most important IGF binding protein in serum, the most abundant carrier protein in milk and CSF. In serum its levels are age dependent. There is no good evidence, to date, for a regulation of its production or degradation by insulin. IGF-I treatment increases serum IGFBP-2 concentration. IGFBP-2 is at least partially metabolized by the kidney, since it accumulates in serum of patients with renal failure and normalizes after renal transplantation. Individuals with neoplastic diseases very often present with elevated serum levels.
Schwander
J
J
Department of Research and Internal Medicine, Kantonspital, University of Basel, Switzerland.
Mary
J L
JL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D002352:Carrier Proteins / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007328:Insulin / Q000378:metabolism; D018971:Insulin-Like Growth Factor Binding Protein 2; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008895:Milk, Human / Q000737:chemistry; D009369:Neoplasms / Q000378:metabolism; D011863:Radioimmunoassay; D012016:Reference Values; D013002:Somatomedins
D002352:Carrier Proteins; D007328:Insulin; D018971:Insulin-Like Growth Factor Binding Protein 2; D013002:Somatomedins