Haemoglobin F and A2 in Nigerian children with sickle cell anaemia.
The concentration of haemoglobins F and A2 in 132 Hb SS children aged 6 months to 16 years and 50 age- and sex-matched controls has been determined. The mean HbF concentration in Hb SS patients and controls were 9.5 per cent (range 1.7-24.5 per cent) and 1.5 per cent (range 0.5-14.4 per cent) respectively while HbA2 concentrations were 2.7 per cent (range 1.6-3.7 per cent) and 2.4 per cent (range 1.3-3.9 per cent) respectively. For 18 Hb SS patients seen in the stable state and during vaso-occlusive crisis, there was no significant difference in HbF concentration between the two states.
Fatunde
O J
OJ
Department of Child Health, University of Benin Teaching Hospital, Nigeria.
Scott-Emuakpor
A B
AB
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005319:Fetal Hemoglobin / Q000502:physiology*; D006443:Hemoglobin A2 / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D009549:Nigeria
D006443:Hemoglobin A2; D005319:Fetal Hemoglobin