title: Malignant germ cell tumours in two siblings.
abstract: Familial germ cell tumours are well recognised in kinship with gonadal dysgenesis, but their occurrence in siblings with normal chromosomes is rare. We report two sisters who presented within a 4 month period with malignant ovarian germ cell tumours; one a dysgerminoma and the other a mixed tumour with marked choriocarcinomatous elements. Both children had a normal female constitutional karyotype and normal phenotype.
authors.affiliation: Department of Paediatric Oncology, Children's Hospital, Sheffield, England.
authors.forename: K I
authors.initials: KI
authors.lastname: Blake
authors.forename: M P
authors.initials: MP
authors.lastname: Gerrard
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D002648:Child; D002822:Choriocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D004407:Dysgerminoma / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D009679:Nuclear Family; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery
chemical_list: D001761:Bleomycin; D005047:Etoposide; D016190:Carboplatin