Experimental autoimmune nigral damage in guinea pigs.
An animal model of experimental autoimmune nigral damage (EAND) has been developed in guinea pigs by immunization with hybrid dopaminergic cells (MES 23.5). In such animals, loss of 40% of the substantia nigra (SN) neurons and damage to an additional 10% of SN neurons was associated with a 37-43% decrease of tyrosine hydroxylase (TH) activity and a 36% decrease of dopamine (DA) content in the nigral-striatum. Eight of the thirteen animals developed significant hypokinesia. The EAND model suggests that degeneration of dopaminergic neurons in SN can be caused by immune-mediated processes, which may help our understanding of the pathogenesis in Parkinson's disease.
Le
W D
WD
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Engelhardt
J
J
Xie
W J
WJ
Schneider
L
L
Smith
R G
RG
Appel
S H
SH
D000818:Animals; D015551:Autoimmunity; D002460:Cell Line; D004298:Dopamine / Q000032:analysis; D005625:Frontal Lobe / Q000737:chemistry; D006168:Guinea Pigs; D006624:Hippocampus / Q000737:chemistry; D007114:Immunization; D008297:Male; D008636:Mesencephalon / Q000276:immunology*; D009069:Movement Disorders / Q000209:etiology; D013378:Substantia Nigra / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine