[Clinico-pharmacological research in studying the chronosensitivity to clofelin of hypertension patients].
In a group of 25 patients with Stage II hypertensive disease, circulatory changes occurring with clofelin, 0.075 mg, were studied in various periods of a day (07.30 a. m. and 0.30, 6.30, and 8.30 p. m.) during acute clinical and pharmacological testing. The findings are indicative of the rhythm of clofelin chronosensitivity, showing its hemodynamic antihypertensive effect provision to be the most beneficial for the body at 6.30 p. m. and to be less at 0.30 p. m.
Zaslavskaia
R M
RM
Akhmetov
K Zh
KZh
Teĭblium
M M
MM
D000704:Analysis of Variance; D001775:Blood Circulation / Q000187:drug effects; D002909:Chronobiology Phenomena / Q000187:drug effects* / Q000502:physiology; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010993:Plethysmography, Whole Body; D013997:Time Factors
D003000:Clonidine