[Indications for irradiated blood components: dose and side effects].
Transfusion-associated graft versus host disease (ta-GvHD) is a rare but almost lethal complication of blood transfusion in immunocompromised patients. To prevent ta-GvHD, irradiated blood products should be given to patients at risk: patients after bone marrow transplantation, newborns and children in the 1st year, patients with severe combined immunodeficiency, and patients receiving blood from first-degree relatives. Blood products should be irradiated at least with 30 Gy just before transfusion. With this regime in practice for 4 years, no complications and side effects were seen.
Eiermann
T H
TH
Abteilung Transfusionsmedizin der Universität Ulm, BRD.
D001769:Blood / Q000528:radiation effects*; D016913:Blood Component Transfusion; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008212:Lymphocyte Depletion; D008214:Lymphocytes / Q000528:radiation effects; D011829:Radiation Dosage; D016511:Severe Combined Immunodeficiency / Q000097:blood