[Effectiveness of chemotherapy and radiotherapy in 60 cases of Hodgkin's lymphoma].
60 cases of Hodgkin's lymphoma were treated with combined chemotherapy and radiotherapy. 35 cases (58.3%) achieved complete remission (CR) and 25 cases (41.7%) partial remission (PR). Five and ten-year survival rates were 55.2% and 47.7% for the entire group. The five and ten-year survival rates were better for patients with stage I (100% and 100%), stage II (69.1% and 62.1%), and stage III (71.5% and 59.6%) than for patients with stage IV (16.2% and 16.2%), better for CR patients (89.4% and 81.3%) than for PR patients (10.1% and 5%) and better for patients with lymphocyte predominating type (75% and 50%) and nodular sclerosis type (74.5% and 65.2%) than for patients with mixed cellularity type (37.7% and 37.7%) and lymphocyte depleted type (0% and 0%). The results show that the stage and histologic type of the disease, the CR rate and the age of the patients had significant effect on the survival of Hodgkin's lymphoma. In order to improve the prognosis, it is important to make diagnosis early and to achieve CR.
Yong
W B
WB
Beijing Institute for Cancer Research.
Wang
H
H
Zhu
X M
XM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002648:Child; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D008875:Middle Aged; D009367:Neoplasm Staging; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011379:Prognosis; D011867:Radioisotope Teletherapy; D011882:Radiotherapy, High-Energy; D015996:Survival Rate; D014747:Vinblastine; D014750:Vincristine / Q000008:administration & dosage
D003037:Cobalt Radioisotopes; D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D011241:Prednisone