title: Galanin-induced growth hormone secretion in conscious rats: evidence for a possible involvement of somatostatin.
abstract: Intracerebroventricular administration of galanin (GAL) potently evoked growth hormone (GH) secretion in conscious male rats. Pretreatments with neostigmine and cysteamine blunted the GAL-induced GH secretion. Pretreatment of animals with a specific anti-somatostatin serum significantly inhibited the GAL-induced GH secretion. On the contrary, GH-releasing hormone-induced GH secretion was significantly enhanced with cysteamine and anti-somatostatin serum. These results suggest that somatostatin is involved in GAL-induced GH secretion in rats.
authors.affiliation: Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanoh
authors.forename: A
authors.initials: A
authors.lastname: Shimatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: C
authors.initials: C
authors.lastname: Ihara
authors.forename: N
authors.initials: N
authors.lastname: Yanaihara
authors.forename: H
authors.initials: H
authors.lastname: Imura
mesh_terms: D000818:Animals; D003543:Cysteamine / Q000494:pharmacology; D019004:Galanin; D013006:Growth Hormone / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D010455:Peptides / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000502:physiology*
chemical_list: D010455:Peptides; D009388:Neostigmine; D013004:Somatostatin; D003543:Cysteamine; D019004:Galanin; D013006:Growth Hormone