[Changes in the membrane potential of rat peritoneal macrophages under the extracellular action of ATP].
In rat peritoneal macrophages the patch-clamp technique in whole-cell configuration was used to study modifications of membrane potential as a result of extracellular application of micromolar ATP concentration. The registered changes in membrane potential appeared to be of different form and polarization depending on the presence of Ca2+ in extracellular solution and on the concentration of calcium buffer inside the cell. A mechanism of membrane potential changes and their possible connection with the generation of a Ca2+ signal in the cell are discussed.
Zubov
A N
AN
Pisareva
L N
LN
Semenova
S B
SB
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000502:physiology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004533:Egtazic Acid / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar
D004533:Egtazic Acid; D000255:Adenosine Triphosphate; D002118:Calcium