Skin anti-inflammatory activity of apigenin-7-glucoside in rats.
The effect of apigenin-7-glucoside on skin inflammation induced by different generators of reactive oxygen species and free radicals was studied. Skin inflammation in rats was induced by intradermal injection of glucose-oxidase (hydrogen peroxide), xanthine-oxidase/hypoxanthine (superoxide anion radical), and cumene hydroperoxide (peroxyl radical). Subsequent intradermal application of liposomal apigenin-7-glucoside inhibited in a dose dependent manner skin inflammation caused by xanthine-oxidase and cumene hydroperoxide. Glucose-oxidase induced dermatitis was not significantly inhibited. The results are in good agreement with the in-vitro superoxide anion radical and peroxyl radical scavenging properties of apigenin and indicate that its antioxidant properties contribute to the anti-inflammatory effect in this model system.
Fuchs
J
J
Abteilung II, Klinikum der Johann Wolfgang Goethe Universität, Frankfurt/Main, Fed. Rep. of Germany.
Milbradt
R
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology; D047310:Apigenin; D001555:Benzene Derivatives / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005419:Flavonoids / Q000494:pharmacology*; D005949:Glucose Oxidase / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D008081:Liposomes; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D014969:Xanthine Oxidase / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001555:Benzene Derivatives; D005419:Flavonoids; D008081:Liposomes; D011453:Prostaglandins; C057792:apigetrin; D047310:Apigenin; D005949:Glucose Oxidase; D014969:Xanthine Oxidase; C007164:cumene hydroperoxide