The canary androgen receptor mRNA is localized in the song control nuclei of the brain and is rapidly regulated by testosterone.
Singing in canaries is an androgen-inducible behavior, under the control of an identified motor pathway, which includes several discrete "song nuclei" in the telencephalon. To determine whether the mRNA for the canary androgen receptor (cAR) is expressed in these song control nuclei, we synthesized probes from the recently cloned cAR cDNA and used in situ hybridization to examine spring male canary brain sections. Concentrations of cAR mRNA are detectable in several of the song control nuclei of the forebrain, including high vocal center (HVC), lateral magnocellular nucleus of the anterior neostriatum and robust nucleus of the archistriatum. In addition, we also show that testosterone treatment rapidly induces a significant reduction of cAR mRNA levels in nucleus HVC of females. Since the effects of androgen on singing behavior occur much more slowly, the behavioral effects are probably a secondary or independent result of androgen's primary and immediate action on target gene transcription.
Nastiuk
K L
KL
Laboratory of Animal Behavior, Rockefeller University, New York, New York 10021, USA.
Clayton
D F
DF
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000502:physiology; D002171:Canaries / Q000235:genetics / Q000502:physiology*; D005260:Female; D008297:Male; D009474:Neurons / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology*; D014827:Vocal Cords / Q000502:physiology; D014828:Vocalization, Animal / Q000187:drug effects
D012333:RNA, Messenger; D011944:Receptors, Androgen; D013739:Testosterone