title: Haemodynamic and plasma catecholamine responses during total intravenous anaesthesia for laryngomicroscopy. Thiopentone compared with propofol.
abstract: We compared the haemodynamic responses to endolaryngeal procedures during anaesthesia with propofol or thiopentone. Two minutes after administration of glycopyrronium 4 micrograms.kg-1 and alfentanil 17.5 micrograms.kg-1 anaesthesia was induced with either propofol 2.0 mg.kg-1 (n = 8) or thiopentone 5.0 mg.kg-1.min-1, respectively. Muscle relaxation was induced and maintained with suxamethonium. Intratracheal jet-ventilation (rate: 20 breath.min-1) was with 100% oxygen. Blood samples for later determination of plasma catecholamines were drawn and haemodynamic responses were recorded at tracheal intubation, after insertion of the operating laryngoscope, during the endolaryngeal procedure and after extubation. With both anaesthetic agents the only statistically significant haemodynamic response to intubation was a rise of heart rate. With propofol, plasma adrenaline concentrations decreased significantly after induction and remained below baseline values throughout the procedure. After insertion of the operating laryngoscope the haemodynamic response was more pronounced with thiopentone than with propofol. Propofol blocks the catecholamine and haemodynamic responses to endolaryngeal procedures more effectively than thiopentone.
authors.affiliation: Department of Anaesthesia, South Carelian Central Hospital, Lappeenranta, Finland.
authors.forename: S T
authors.initials: ST
authors.lastname: Mustola
authors.forename: G A
authors.initials: GA
authors.lastname: Baer
authors.forename: T
authors.initials: T
authors.lastname: Metsä-Ketelä
authors.forename: P
authors.initials: P
authors.lastname: Laippala
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D015742:Propofol / Q000494:pharmacology; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors
chemical_list: D018686:Anesthetics, Intravenous; D013874:Thiopental; D009638:Norepinephrine; D015742:Propofol; D004837:Epinephrine