Mapping of the gene for interferon-inducible dsRNA-dependent protein kinase to chromosome region 2p21-22: a site of rearrangements in myeloproliferative disorders.
Recent evidence suggests that the human interferon-inducible double-stranded RNA-dependent protein kinase may function as a tumor suppressor. Here we describe the mapping of the gene for this kinase to chromosome region 2p21-22 by fluorescence in situ hybridization. A combined analysis of cytogenetic data from a series of 341 patients with hematologic disorders that exhibited cytogenetic abnormalities and from published reports indicates that abnormalities involving 2p21-22 occur nonrandomly and are observed among patients with acute myelogenous leukemia, raising the possibility of a role for this protein kinase in leukemogenesis.
Hanash
S M
SM
Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor.
Beretta
L
L
Barcroft
C L
CL
Sheldon
S
S
Glover
T W
TW
Ungar
D
D
Sonenberg
N
N
D001853:Bone Marrow / Q000201:enzymology / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D004790:Enzyme Induction; D005260:Female; D006402:Hematologic Diseases / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007372:Interferons / Q000494:pharmacology*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D008297:Male; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis / Q000235:genetics*; D019892:eIF-2 Kinase
D007372:Interferons; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase