title: Validation of World Health Organization guidelines for pain relief in head and neck cancer. A prospective study.
abstract: In a prospective study of 167 patients with head and neck cancer, we assessed the causes and mechanisms of pain, as well as the efficacy and side effects of analgesic treatment, along World Health Organization (WHO) guidelines. The majority of patients had pain caused by cancer (83%) and/or treatment (28%), 4% had pain due to debility, and 7% had pain unrelated to cancer. Palliative antineoplastic treatment was performed in 32% of patients. Systemic analgesics were administered on 97% of a total of 8,106 treatment days, and coanalgesics or adjuvant drugs on 100%. The treatment proved to be very successful, as severe pain was experienced only during 5% of the observation period. In the absence of serious side effects, the most frequent symptoms observed were insomnia, dysphagia, anorexia, constipation, and nausea. The use of analgesic and adjuvant drugs along WHO guidelines to treat pain in head and neck cancer is highly effective and relatively safe.
authors.affiliation: Department of Anesthesiology and Operative Intensive Care, University of Cologne, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Grond
authors.forename: D
authors.initials: D
authors.lastname: Zech
authors.forename: J
authors.initials: J
authors.lastname: Lynch
authors.forename: C
authors.initials: C
authors.lastname: Diefenbach
authors.forename: S A
authors.initials: SA
authors.lastname: Schug
authors.forename: K A
authors.initials: KA
authors.lastname: Lehmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010166:Palliative Care; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D014944:World Health Organization
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid