[The hemodynamic and renal effects of synthetic atriopeptides in waking rats under conditions of volumetric loading].
Changes in mean blood pressure (MBP), heart rate (HR), diuresis, natriuresis and kaliuresis, which had been evoked by intravenous bolus administration of the synthetic atrial natriuretic peptides (ANP) ANP (99-126), ANP (103-126), ANP (103-125), and ANP (103-123) in doses of 10 and 60 micrograms/kg each, were studied during 2% body weight volume expansion by intraarterial injections of 0.9% NaCl in awake rats. All the ANP analogues were indicated to decrease MBP and induce differential changes in HR. All the ANP analogues, except ANP (103-123), increased diuresis and natriuresis in the first 30 min of the experiment.
Murashev
A N
AN
Smetanina
M D
MD
Davydova
S A
SA
Bespalova
Zh D
ZhD
Medvedev
O S
OS
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001810:Blood Volume / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage; D018709:Statistics, Nonparametric; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D010446:Peptide Fragments; D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor