title: Ultraviolet irradiation induces acute changes in melanocytic nevi.
abstract: Ultraviolet (UV) light represents one of the factors that might play a role in the initiation and promotion of malignant transformation of human melanocytes. To determine the short-term effects of UV irradiation on melanocytic nevi in vivo, we investigated one half of symmetric melanocytic nevi after a single UV exposure with double the patient's minimal erythema dose. This half was compared with the nonirradiated, shielded half of the same nevus. The different parts were examined histologically for differences and immunohistochemically for the presence of HMB-45 antigen and proliferating cell nuclear antigen. The features were assessed quantitatively by image analysis. One week after the single UV irradiation, we observed a significant increase of suprabasally located melanocytes and a markedly enhanced expression of HMB-45, whereas proliferative activity of the cells was unchanged. In nevi that were excised 2 or 3 weeks after irradiation, no significant differences were observed between the irradiated and the nonirradiated part. The results indicate that a single UV irradiation may induce transient melanocytic activation with morphologic and histologic changes. Although these data do not formally assess resemblance to melanoma, these changes may be similar to those of melanoma in situ.
authors.affiliation: Department of Dermatology, Medical University of Lübeck, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Tronnier
authors.forename: J
authors.initials: J
authors.lastname: Smolle
authors.forename: H H
authors.initials: HH
authors.lastname: Wolff
mesh_terms: D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm; D002455:Cell Division / Q000528:radiation effects; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000473:pathology; D008297:Male; D008544:Melanocytes / Q000187:drug effects / Q000473:pathology; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009508:Nevus, Pigmented / Q000473:pathology*; D014466:Ultraviolet Rays
chemical_list: D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins