title: Cytotoxic constituents of Bursera permollis.
abstract: Four cytotoxic lignans were isolated from the stem bark of Bursera permollis (Burseraceae), namely, deoxypodophyllotoxin (1), beta-peltatin methyl ether (2), picro-beta-peltatin methyl ether (3), and dehydro-beta-peltatin methyl ether (4). Also isolated was the inactive lignan, nemerosin (5). Compounds 1 and 2 were potently cytotoxic when evaluated against a panel of human cancer cell lines.
authors.forename: D B
authors.initials: DB
authors.lastname: Wickramaratne
authors.forename: W
authors.initials: W
authors.lastname: Mar
authors.forename: H
authors.initials: H
authors.lastname: Chai
authors.forename: J J
authors.initials: JJ
authors.lastname: Castillo
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: D D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D010944:Plants / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic