Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection.
Patients who have undergone gastric resection are at higher risk of developing gastric carcinoma than normal subjects, and bile reflux is believed to play a role in carcinogenesis. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging, particularly where there is chronic epithelial injury associated with bile reflux. Helicobacter pylori is considered a major risk factor for gastric cancer in the intact stomach. It has been shown previously that antral cell proliferation is increased in H pylori gastritis and falls to normal levels after eradication of the organism. Little is known of corpus cell proliferation in H pylori gastritis or after gastric resection. Using in vitro bromodeoxyuridine labelling of endoscopic biopsy specimens we have found that corpus cell proliferation is increased in H pylori gastritis. Cell proliferation was greater in corpus biopsy specimens of resected stomachs than in H pylori gastritis. Subgroup analysis of patients who had undergone gastric resection indicated that those positive for H pylori had higher levels of cell proliferation than those negative for the organism. These findings provide further evidence that H pylori and bile have a role in gastric carcinogenesis and suggest that their presence has a synergistic effect on gastric epithelial cell proliferation.
Lynch
D A
DA
Centre for Digestive Diseases, General Infirmary at Leeds.
Mapstone
N P
NP
Clarke
A M
AM
Jackson
P
P
Dixon
M F
MF
Quirke
P
P
Axon
A T
AT
D000328:Adult; D001655:Bile Reflux / Q000473:pathology; D001973:Bromodeoxyuridine; D002452:Cell Count; D002455:Cell Division; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011184:Postoperative Period; D013270:Stomach / Q000473:pathology* / Q000601:surgery
D001973:Bromodeoxyuridine