[Steroid hormones and the etiopathogenesis of liver lesions of a fibrotic nature].
It has been hypothesized that the hormonal status is involved in the distinct susceptibility between men and women towards the development of hepatobiliary disease because the liver is target organ for steroid hormones. In the development of the fibrogenic phenomenon present in the hepatic cirrhosis of diverse etiology, Ito cells, myofibroblasts as well as some cytokines like transforming growth factor-beta, interleukin-6 and tumor necrosis factor-alpha are involved. It is known that in the organism exist regulatory loops among cytokines, glucocorticoids and sex steroids; in the liver this interaction could affect the fibrogenic phenomenon through Ito cells differentiation. The knowledge of the precise role of glucocorticoids and sex steroids on the fibrogenic mechanisms should allow to support rationally the viability of hormone manipulation for the treatment of hepatic diseases of fibrotic nature.
Reyes Romero
M A
MA
Departamento de Bioquímica, Facultad de Medicina, Universidad Juárez del Estado de Durango, México.
Burciaga Nava
J A
JA
D016207:Cytokines / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008103:Liver Cirrhosis / Q000209:etiology* / Q000378:metabolism; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D011374:Progesterone / Q000494:pharmacology
D016207:Cytokines; D006728:Hormones; D011374:Progesterone