Early postnatal antidepressant treatment and juvenile stereotyped behaviour in rats.
The effect of antidepressants on stereotyped behaviour in rats during development was examined. Rats were injected s.c. once a day from the 6th to the 22th day after birth with 0.9% sodium chloride, with desipramine 5 mg/kg body weight, with nomifensine 10 mg/kg, or with zimelidine 25 mg/kg. Stereotyped behaviour was assessed when the rats were 1 month and 2 months of age. Desipramine intensified and prolonged apomorphine 0.5 mg/kg induced stereotyped behaviour at 1 month but not at 2 months of age. Nomifensine and zimelidine did not affect stereotyped behaviour at either 1 month or 2 months of age. Thus, 2-week treatment with desipramine during early development was shown to increase stereotyped behaviour at a juvenile age.
Hilakivi
I
I
Department of Biomedicine, University of Helsinki, Finland.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009627:Nomifensine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*; D015031:Zimeldine / Q000494:pharmacology
D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D009627:Nomifensine; D015031:Zimeldine; D001058:Apomorphine; D003891:Desipramine