title: Repeated treatment with fluoxetine decreases the number of spontaneously active cells per track in frontal cortex.
abstract: Repeated (10 mg/kg i.p. x 14 days, once daily), but not acute (10 and 40 mg/kg i.p., 30 min), treatment with fluoxetine decreased the number of active neurons in the frontal cortex 30 min (-55%) or 24 h (-62%) after the last drug injection. This result supports the view that repeated, but not acute, treatment with fluoxetine decreases the function of the frontal cortex.
authors.affiliation: Department of Pharmacology, Boehringer Ingelheim Italia, Milan.
authors.forename: A
authors.initials: A
authors.lastname: Ceci
authors.forename: F
authors.initials: F
authors.lastname: Fodritto
authors.forename: F
authors.initials: F
authors.lastname: Borsini
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004594:Electrophysiology; D005473:Fluoxetine / Q000494:pharmacology*; D005625:Frontal Lobe / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005473:Fluoxetine