Decreased cortical octopamine level in basal forebrain lesioned rats: a microdialysis study.
Ibotenic acid-induced lesion of the basal forebrain resulted after 13 days in a 90% reduction of octopamine (OA) in the frontoparietal cortex of adult rats, whereas dihydroxyphenylacetic (DOPAC), homovanillic (HVA) and 5-hydroxyindoleacetic (5-HIAA) acids were not modified as measured by microdialysis and high-performance liquid chromatography (HPLC) with electrochemical detection. At this time, cortical choline acetyltransferase (ChAT) activity was decreased by 34%. The results are discussed with respect to possible octopamine involvement in reduced age-associated performance in neurodegenerative processes.
Bendahan
G
G
Unit of Biochemistry, School of Medicine, University of Barcelona, Spain.
Boatell
M L
ML
Mahy
N
N
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis; D005625:Frontal Lobe / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007051:Ibotenic Acid / Q000633:toxicity; D008297:Male; D008832:Microchemistry; D009655:Octopamine / Q000378:metabolism*; D010296:Parietal Lobe / Q000378:metabolism*; D016548:Prosencephalon / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D015102:3,4-Dihydroxyphenylacetic Acid; D009655:Octopamine; D007051:Ibotenic Acid; D006897:Hydroxyindoleacetic Acid; D002795:Choline O-Acetyltransferase; D006719:Homovanillic Acid