title: [The suppression of the cerebrovascular constrictor effects of malondialdehyde by GABA-ergic substances].
abstract: GABA and its cyclic derivatives, gamma-butyrolactone and pyrrolidone-2, have been ascertained to abolish and prevent the cerebral vasoconstrictor effects of malonic dialdehyde. In this respect, gamma-butyrolactone excels pyrrolidone-2 and GABA, the effects of GABA being most slight. It may be suggested that the neuroactive amino acids exhibit antioxidative effects.
authors.forename: S A
authors.initials: SA
authors.lastname: Mirzoian
authors.forename: V P
authors.initials: VP
authors.lastname: Akopian
authors.forename: A A
authors.initials: AA
authors.lastname: Manukian
mesh_terms: D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D008315:Malondialdehyde / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D011760:Pyrrolidinones; D008315:Malondialdehyde; D005680:gamma-Aminobutyric Acid; C028537:2-pyrrolidone; D015107:4-Butyrolactone