Sudden onset of adverse effects due to low-dosage bleomycin indicates an idiosyncratic reaction.
We report a case of possible idiosyncratic reaction in a fifty-two-year-old man with centroblastic malignant lymphoma. Immediately after administration of 20 mg bleomycin intravenously for the first time, the patient developed stomatitis. When readministered a few weeks later the patient developed mucocutaneous manifestations such as stomatitis, symmetrical linear maculopapular exanthema on the neck, trunk, and both arms, and indurated nodules on the palms.
Haerslev
T
T
Department of Pathology, Gentofte University Hospital, Hellerup, Denmark.
Avnstorp
C
C
Joergensen
M
M
D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013280:Stomatitis / Q000139:chemically induced*
D001761:Bleomycin