title: MR imaging with hyperpolarized 3He gas.
abstract: Magnetic resonance images of the lungs of a guinea pig have been produced using hyperpolarized helium as the source of the MR signal. The resulting images are not yet sufficiently optimized to reveal fine structural detail within the lung, but the spectacular signal from this normally signal-deficient organ system offers great promise for eventual in vivo imaging experiments. Fast 2D and 3D GRASS sequences with very small flip angles were employed to conserve the norenewable longitudinal magnetization. We discuss various unique features associated with performing MRI with hyperpolarized gases, such as the selection of the noble gas species, polarization technique, and constraints on the MR pulse sequence.
authors.affiliation: Department of Physics, Princeton University, NJ 08544-0708, USA.
authors.forename: H
authors.initials: H
authors.lastname: Middleton
authors.forename: R D
authors.initials: RD
authors.lastname: Black
authors.forename: B
authors.initials: B
authors.lastname: Saam
authors.forename: G D
authors.initials: GD
authors.lastname: Cates
authors.forename: G P
authors.initials: GP
authors.lastname: Cofer
authors.forename: R
authors.initials: R
authors.lastname: Guenther
authors.forename: W
authors.initials: W
authors.lastname: Happer
authors.forename: L W
authors.initials: LW
authors.lastname: Hedlund
authors.forename: G A
authors.initials: GA
authors.lastname: Johnson
authors.forename: K
authors.initials: K
authors.lastname: Juvan
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006371:Helium / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects; D007089:Image Enhancement / Q000379:methods; D007834:Lasers; D008168:Lung / Q000033:anatomy & histology* / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D012413:Rubidium / Q000737:chemistry / Q000528:radiation effects; D013997:Time Factors
chemical_list: D006371:Helium; D012413:Rubidium