Effect of antiepileptic drugs on erythrocyte osmotic fragility and lipid peroxidation.
Epileptic children receiving antiepileptics were studied to investigate the effect of carbamazepine and phenobarbital therapy on erythrocyte osmotic fragility and lipid peroxidation. Significant differences between the two groups were observed in erythrocyte osmotic fragility. In addition, there was a significant increase in erythrocyte malondialdehyde release in the epileptic group compared to controls. It is suggested that the use of antioxidants in addition to antiepileptic drugs may be beneficial.
Yalçin
A D
AD
Department of Neurology, Sişli Etfal Hospital, Istanbul, Turkey.
Onaran
I
I
Yalçin
A S
AS
D000293:Adolescent; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D004828:Epilepsies, Partial / Q000188:drug therapy*; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D009996:Osmotic Fragility / Q000187:drug effects*
D000927:Anticonvulsants