Frequency of chromosomal aberrations after exposure to gamma-radiation of human chorionic villi.
We investigated the chromosomal damage induced by in vitro exposure to gamma-rays of uncultured first trimester chorionic villi. Frequency and types of chromosomal aberrations at increasing doses of radiation have been evaluated on cytotrophoblast spontaneous metaphases obtained after a short term incubation. Our results indicate a direct correlation between radiation dose and aberration frequency.
Salvi
R
R
Centro Trasfusionale, Istituti Clinici di Perfezionamento, Milan, Italy.
De Andreis
C
C
Pariani
S
S
Orsini
S
S
Piantanida
M
M
Rossella
F
F
Simoni
G
G
D002824:Chorionic Villi / Q000528:radiation effects*; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D008677:Metaphase