title: [Evaluation of various experimental dyslipoproteinemia models in the study of hypolipidemic agents].
abstract: Models of experimental dyslipoproteinemias have been developed by using non-inbred rats (males and females) and guinea-pigs. Administration of cholesterol (C) with fats and supplementation of 4-hydroxy-6-methyl-2-thiouracil to male rats and that of C in the mixture of fats to guinea-pigs have been demonstrated to lead to the development of atherogenic dyslipoproteinemias. Genfibrozil, cholestyramine and vasosan II, a new pectin-enriched formulation, promoted normalization of the impaired serum lipoprotein spectrum caused by exogenous C administration. Bilateral ovariectomy in female rats induced atherogenic dyslipoproteinemia. The use of the estrogen derivative methyl ether of 6-oxa-D-homo-8-isoestrone normalized lipid and lipoprotein metabolic disturbances.
authors.forename: V E
authors.initials: VE
authors.lastname: Ryzhenkov
authors.forename: A M
authors.initials: AM
authors.lastname: Chistiakova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Frolova
authors.forename: V T
authors.initials: VT
authors.lastname: Lozovskiĭ
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Kameneva
authors.forename: L E
authors.initials: LE
authors.lastname: Vasil'eva
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005260:Female; D006168:Guinea Pigs; D006951:Hyperlipoproteinemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D051381:Rats
chemical_list: D000960:Hypolipidemic Agents