title: Benign hyperplastic nodules that originate in the peripheral zone of the prostate gland.
abstract: OBJECTIVE
  To describe a benign nodular lesion in the peripheral zone (PZ) of the prostate gland.
  
  
  METHODS
  In 1,087 patients, the features of 722 focal lesions in the PZ or central zone of the prostate on transrectal ultrasound (TRUS) scans were retrospectively compared with histologic findings in biopsy samples.
  
  
  RESULTS
  In 18 patients (5.5% of the 328 patients with benign lesions), benign hyperplasia was found in a focal, nodular lesion obviously located within the PZ. On TRUS scans, the nodules were well circumscribed, ovoid or round, and slightly hypoechoic (n = 11) or isoechoic (n = 7). The isoechoic lesions were surrounded by an anechoic halo. One nodule was an incidental sonographic finding; the 17 others were felt as firm (n = 11) or soft (n = 6) at digital rectal examination. The ratio of serum prostate-specific antigen (PSA) level to prostatic volume was low (< 0.1), except in one patient (0.24).
  
  
  CONCLUSIONS
  Some sonographic features and the normal PSA values might suggest a benign nodule in the PZ, but TRUS-guided biopsies and histologic correlation are necessary to confirm the diagnosis.
authors.affiliation: Department of Radiology, University Hospital, Catholic University of Leuven, Belgium.
authors.forename: R H
authors.initials: RH
authors.lastname: Oyen
authors.forename: W M
authors.initials: WM
authors.lastname: Van de Voorde
authors.forename: H P
authors.initials: HP
authors.lastname: Van Poppel
authors.forename: P P
authors.initials: PP
authors.lastname: Brys
authors.forename: F E
authors.initials: FE
authors.lastname: Ameye
authors.forename: Y M
authors.initials: YM
authors.lastname: Franssens
authors.forename: A L
authors.initials: AL
authors.lastname: Baert
authors.forename: L V
authors.initials: LV
authors.lastname: Baert
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D010808:Physical Examination; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen