[The role of the microsomal mono-oxygenase system in modifying the effect of mutagens].
The paper summarizes the results of several studies to modify the effects of the indirect-acting mutagen cyclophosphamide and the direct-acting fotrin in the presence of varying activity of the microsomal monooxygenase system. It also first shows how the effects of the mutagens are modified by inducing or inhibiting monooxygenase activity. A regression modification index is proposed to measure the level and direction of modification of mutagenic effects in experiments on mammals.
Zhurkov
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VS
Sycheva
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D000818:Animals; D001388:Aziridines / Q000493:pharmacokinetics / Q000494:pharmacology; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000493:pharmacokinetics / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009153:Mutagens / Q000493:pharmacokinetics / Q000494:pharmacology*; D010105:Oxygenases / Q000187:drug effects / Q000378:metabolism*; D010634:Phenobarbital / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D001388:Aziridines; D009153:Mutagens; C007779:fotrin; D003520:Cyclophosphamide; D010105:Oxygenases; D010634:Phenobarbital