Type D SRV-2 virus-specific CD8+ and CD4- CD8- T cells that regulate virus-induced T cell proliferation in Celebes macaques.
These studies defined SRV-2 envelope peptides 96-102, 127-152, and 233-249 as T cell epitopes that induce significant T cell proliferation. Peripheral blood lymphocytes of Celebes macaques (Macaca nigra) exposed to SRV-2 and currently virus- antibody+, cultured with SRV-2 virus show strongly suppressed T cell responses and have two immunoregulatory T cell populations.
Malley
A
A
Oregon Regional Primate Research Center, Beaverton 97006.
Pangares
N
N
Mayo
S K
SK
Zeleny-Pooley
M
M
Torres
J V
JV
Benjamin
E
E
Axthelm
M K
MK
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D015704:CD4 Antigens; D016827:CD8 Antigens; D000939:Epitopes; D007108:Immune Tolerance; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008251:Macaca / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D015301:Retroviruses, Simian / Q000276:immunology* / Q000302:isolation & purification; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000382:microbiology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology
D000914:Antibodies, Viral; D015704:CD4 Antigens; D016827:CD8 Antigens; D000939:Epitopes; D010446:Peptide Fragments; D014759:Viral Envelope Proteins