Resistance of Pseudomonas pseudomallei growing as a biofilm on silastic discs to ceftazidime and co-trimoxazole.
We have examined the resistance of Pseudomonas pseudomallei biofilm cells to ceftazidime and cotrimoxazole. A large number of these biofilm cells remained viable at 12 and at 24 h, except in the biofilm treated with 200 times the MIC of ceftazidime. The inherent resistance of P. pseudomallei biofilms to conventional antibiotics may explain the lack of success in the treatment of the chronic manifestations of this bacterial infection.
Vorachit
M
M
Ramathibodi Hospital, Bangkok, Thailand.
Lam
K
K
Jayanetra
P
P
Costerton
J W
JW
D016957:Burkholderia pseudomallei / Q000187:drug effects* / Q000254:growth & development; D002442:Ceftazidime / Q000494:pharmacology*; D004058:Diffusion; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D012826:Silicone Elastomers; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
D012826:Silicone Elastomers; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002442:Ceftazidime