[Case observations on the significance of early pregnancy factor as a tumor marker].
At three patients who have been operated on because of completely different tumours (trophoblast tumour, endodermalsinus tumour of the right ovary and rhabdomyosarcoma as well as adrenal cortex carcinoma) pre-operatively the Early Pregnancy Factor (EPF) could in each case be shown in the serum with the help of the rosette inhibition test. In two cases the EPF already intra-operatively disappeared from the serum. In the third case it could be found until the second day after operation. Since that patient suffered from two histogenetically non-related malignant tumours it was not possible to trace whether the adrenal cortex carcinoma or the rhabdomyosarcoma have been the reason for the EPF-synthesis. The already intra-operative disappearance and the also during further post-operative controls unsuccessful proof of EPF in serum can indicate an opportunity for the early assessment of efficiency of the surgical treatment of tumours which develop EPF or which induce the EPF-synthesis.
Bojahr
B
B
Klinik, Ernst-Moritz-Arndt-Universität Greifswald.
Straube
W
W
Reddemann
H
H
D000008:Abdominal Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D014408:Biomarkers, Tumor / Q000097:blood*; D018835:Chaperonin 10; D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D007044:Hysterectomy; D007166:Immunosuppressive Agents / Q000097:blood*; D007223:Infant; D008649:Mesonephroma / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D010052:Ovariectomy; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins; D012208:Rhabdomyosarcoma / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D013491:Suppressor Factors, Immunologic; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery
D014408:Biomarkers, Tumor; D018835:Chaperonin 10; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D007166:Immunosuppressive Agents; D010446:Peptide Fragments; D010455:Peptides; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; C025124:early pregnancy factor