Platelet aggregation and dense granule secretion in schizophrenia.
The functional state of platelets and their possible impairment in response to various stimuli were assessed in saline-diluted citrated blood samples of normal male control subjects (n = 27), and in schizophrenic patients with (n = 34) and without (n = 23) haloperidol treatment. In response to collagen, but not to arachidonic acid (AA) and adenosine diphosphate, platelet aggregation (as measured by changes in impedance) was significantly higher in both haloperidol-treated and drug-free schizophrenic patients than in normal control subjects. Comparison of the secretion traces, however, indicated that only AA-induced adenosine triphosphate (ATP) release was significantly lower in haloperidol-treated schizophrenic patients than in normal control subjects. In response to thrombin, collagen, and AA, the mean values of ATP release from drug-free patients were significantly higher than those from the same individuals when they were receiving haloperidol. Furthermore, there was a trend toward increased ATP release (in response to thrombin or collagen) in the nonrelapsed group of drug-free schizophrenic patients as compared with the relapsed group. The collagen-induced platelet aggregation or dense granule secretion in drug-free patients was correlated significantly and negatively with psychosis ratings. Such changes in platelet function of schizophrenic patients were not correlated significantly with daily haloperidol dose, plasma haloperidol levels, age of subjects, age of onset, or duration of illness.
Yao
J K
JK
Neurochemistry and Psychopharmacology Laboratory, Highland Drive Department of Veterans Affairs Medical Center (DVAMC), Pittsburgh, PA, USA.
van Kammen
D P
DP
Gurklis
J
J
Peters
J L
JL
D000255:Adenosine Triphosphate / Q000097:blood* / Q000378:metabolism; D000328:Adult; D017668:Age of Onset; D016718:Arachidonic Acid / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D012565:Schizophrenic Psychology; D013917:Thrombin / Q000494:pharmacology
D016718:Arachidonic Acid; D000255:Adenosine Triphosphate; D003094:Collagen; D013917:Thrombin; D006220:Haloperidol