Interaction of pargyline with tolbutamide in rabbits.
Acute treatment of rabbits with pargyline (50 mg/kg, ip, 30 min before tolbutamide) significantly increased the elimination half life and AUC0-->infinity of tolbutamide resulting in prolonged hypoglycaemia. Similar treatment also prolonged the half life of antipyrine which is used as model drug to indicate hepatic microsomal enzyme activity in vivo confirming that pargyline treatment delayed the elimination of tolbutamide in rabbits by inhibiting its hepatic metabolism.
Satyanarayana
S
S
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam.
Krishna
D M
DM
Krishnaiah
Y S
YS
Visweswaram
D
D
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics; D001786:Blood Glucose / Q000032:analysis; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D007003:Hypoglycemia / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010293:Pargyline / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D011817:Rabbits; D014044:Tolbutamide / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*
D001786:Blood Glucose; D014044:Tolbutamide; D010293:Pargyline; D000983:Antipyrine