Cytotoxic T lymphocyte epitopes shared between HIV-1, HIV-2, and SIV.
A peptide epitope from the gag protein of SIV and from HIV-1 is described which is presented by a cynomolgus macaque MHC molecule and with HLA B14. Comparisons were drawn between recognition of this peptide and that of a second peptide defined in SIV and HIV-2 which has been reported to be presented by the rhesus macaque molecule MaMuA01 and HLA B53 respectively.
Gotch
F
F
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, U.K.
Nixon
D
D
Gallimore
A
A
McAdam
S
S
McMichael
A
A
D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D000956:Antigens, Viral / Q000235:genetics; D000939:Epitopes / Q000235:genetics; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D015498:HIV-2 / Q000235:genetics / Q000276:immunology*; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D006649:Histocompatibility Antigens; D006801:Humans; D066298:In Vitro Techniques; D008252:Macaca fascicularis; D008297:Male; D008969:Molecular Sequence Data; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination
D000956:Antigens, Viral; D000939:Epitopes; D015683:Gene Products, gag; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D006649:Histocompatibility Antigens