Structural evidence for a dichotomy in rodent carcinogenesis: involvement of genetic and cellular toxicity.
The structural determinants identified as associated with carcinogenicity in rodents were compared to the structural determinants associated with mutagenicity in Salmonella and toxicity to cultured cells. The analysis revealed that the determinants of carcinogenicity could be separated into two almost mutually exclusive groups: Those associated with mutagenicity (and electrophilicity) and those associated with cell toxicity. These findings provide evidence for two mechanisms of cancer induction: A genotoxic one and a non-genotoxic one associated with cell toxicity.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Klopman
G
G
D016475:3T3 Cells; D000818:Animals; D016466:CHO Cells; D002273:Carcinogens / Q000737:chemistry* / Q000633:toxicity; D002478:Cells, Cultured; D006224:Cricetinae; D051379:Mice; D009153:Mutagens / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D012475:Salmonella / Q000187:drug effects; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009153:Mutagens