title: Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis.
abstract: We report here our results on IgM anti-sulfated glucuronyl paragloboside (SGPG) antibodies in sera from patients with amyotrophic lateral sclerosis (ALS). Studies by enzyme linked immunosorbent assay on 72 ALS sera showed IgM polyclonal reactivity towards SGPG in 25 cases. The titer was high in 16 cases. Thin-layer chromatography immuno-overlay showed that reactivity with SGPG was associated to reactivity towards GM1 in five cases and to GM1 and GD1b in one case. Anti-SGPG reactivity was not found in controls and in multifocal motor neuropathy with conduction blocks, in contrast to anti-GM1 antibodies. The presence of anti-SGPG antibodies in ALS patients sera raise again the question of autoimmunity in this pathology.
authors.affiliation: INSERM U 134, Salpetriere Hospital, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Ben Younes-Chennoufi
authors.forename: A
authors.initials: A
authors.lastname: Rozier
authors.forename: M
authors.initials: M
authors.lastname: Dib
authors.forename: P
authors.initials: P
authors.lastname: Bouche
authors.forename: L
authors.initials: L
authors.lastname: Lacomblez
authors.forename: N
authors.initials: N
authors.lastname: Mombo
authors.forename: G
authors.initials: G
authors.lastname: Ben Simon
authors.forename: R K
authors.initials: RK
authors.lastname: Yu
authors.forename: N
authors.initials: N
authors.lastname: Baumann
authors.forename: V
authors.initials: V
authors.lastname: Meininger
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005915:Globosides / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D005915:Globosides; D007075:Immunoglobulin M; C051917:sulfate-3-glucuronyl paragloboside