Trace element distribution in rat brain following lead and lithium supplementation--a study using an EDXRF spectrometer.
Distribution of K, Fe, Cu, Zn, Br and Rb in whole brain samples following combined Pb and Li administration to female Porton rats has been investigated by using the Energy Dispersive x-Ray Fluorescence (EDXRF) technique. Brain K, Cu and Rb levels are diminished, whereas Fe and Br levels are enhanced significantly following short-term (1 month) and long-term (4 months) combined treatment with Li (1.1 g/kg diet) and two doses of Pb (50 and 100 mg/kg body weight). The Zn levels are lowered following combined treatment with Li and both the doses of Pb given for short-term only.
Singh
B
B
Department of Biophysics, Panjab University, Chandigarh, India.
Dhawan
D
D
Chand
B
B
Mangal
P C
PC
Trehan
P N
PN
D000818:Animals; D005260:Female; D007854:Lead / Q000494:pharmacology*; D016651:Lithium Carbonate / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D014131:Trace Elements / Q000032:analysis / Q000378:metabolism*
D009942:Organometallic Compounds; D014131:Trace Elements; D016651:Lithium Carbonate; D007854:Lead; C008261:lead acetate