title: Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas.
abstract: Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progesterone, actinomycin D, and cycloheximide has served to determine the mechanism of action in relationship with that of glucocorticoids. Betulinic acid was the most affected and therefore a mode of action similar to these drugs may be postulated for it.
authors.affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Recio
authors.forename: R M
authors.initials: RM
authors.lastname: Giner
authors.forename: S
authors.initials: S
authors.lastname: Máñez
authors.forename: J
authors.initials: J
authors.lastname: Gueho
authors.forename: H R
authors.initials: HR
authors.lastname: Julien
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
authors.forename: J L
authors.initials: JL
authors.lastname: Ríos
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D005260:Female; D051379:Mice; D053978:Pentacyclic Triterpenes; D010946:Plants, Medicinal / Q000737:chemistry*; D013256:Steroids; D014315:Triterpenes / Q000494:pharmacology*; D000094062:Betulinic Acid; D000097245:Ursolic Acid
chemical_list: D000893:Anti-Inflammatory Agents; D053978:Pentacyclic Triterpenes; D013256:Steroids; D014315:Triterpenes; D000094062:Betulinic Acid; D000097245:Ursolic Acid; C002503:betulin