New NO-donors with antithrombotic and vasodilating activities, XI: 2-Nitrosiminobenzimidazoles.
Thirteen 1,3-disubstituted title compounds were synthesized and tested for their antiplatelet activity (Born test, collagen). Three derivatives inhibited the platelet aggregation halfmaximally in concentrations < 20 mumol/L.
Rehse
K
K
Institut für Pharmazie, Freien Universität Berlin, Dahlem.
Birkhofer
G
G
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009603:Nitroso Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D001562:Benzimidazoles; D005343:Fibrinolytic Agents; D009603:Nitroso Compounds; D014665:Vasodilator Agents