[Comparative thrombotic risk of two contrast agents in coronary angiography].
The thrombogenic risk of contrast agents in coronary angiography is still a topical issue, particularly in comparisons between ionic and nonionic contrast agents. As a complement to a preliminary study, the repercussions on sensitive markers of haemostasis were investigated in vivo in 38 patients undergoing a standard cardiac catheterisation. After randomization, an ionic low osmolality contrast agent (Ioxaglate 320) was used in 19 patients and a nonionic low osmolality contrast agent (Iopromide 370) was used in another 19 patients, according to an identical protocol. The following parameters were assayed in arterial blood samples obtained before and after the examination in each patient: platelet markers: beta-thromboglobulin (beta TG) and platelet factor IV (PF4); prethrombotic markers: thrombin-antithrombin 3 complex (TAT) and prothrombin fragments 1 and 2 (F1 + 2) as well as partial exploration of fibrinolysis: tissue plasminogen activator inhibitors (PAI). Comparison of the results demonstrated platelet activation and the presence of prethrombotic markers in both groups. No significant difference was detected between the two groups of patients. Consequently, there does not appear to be any difference in activation of coagulation between modern, low osmolality, ionic or nonionic contrast agents. This may suggest an equivalent thrombogenic risk.
Wolff
F
F
CMCO, Strasbourg-Schiltigheim.
Zupan
M
M
Klero de Rosbo
P
P
Wiesel
M L
ML
Grunebaum
L
L
Cazenave
J P
JP
Brechenmacher
C
C
D001780:Blood Coagulation Tests; D003287:Contrast Media; D017023:Coronary Angiography / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007485:Ioxaglic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012307:Risk Factors; D013923:Thromboembolism / Q000139:chemically induced*; D010959:Tissue Plasminogen Activator
D003287:Contrast Media; D010959:Tissue Plasminogen Activator; D007485:Ioxaglic Acid