Beta 1-adrenergic mechanism is involved in stress-induced increase in arousal.
It has been shown that 1 h restraint shortens pentobarbital (PbNa)-induced sleeping time and that brain corticotropin-releasing hormone (CRH) is involved in the mechanism by which restraint shortens. PbNa-induced sleeping time. The present study was designed to further examine the mechanism of the antagonistic effect of 1 h restraint on PbNa in rats. Intracerebroventricular (i.c.v.) administration of propranolol and metoprolol, but not butoxamine reversed the shortening of PbNa-induced sleeping time by 1 h restraint. The i.c.v. administration of phentolamine blocked the shortening of PbNa-induced sleeping time by restraint, while the same dose of phentolamine prolonged the sleeping time in unrestrained rats. Atropine did not affect the PbNa-induced sleeping time in restrained rats. These results suggest that in addition to CRH, the brain beta 1-adrenergic system is involved in the restraint stress-induced increase in arousal.
Shibasaki
T
T
Department of Medicine, Tokyo Women's Medical College, Japan.
Yamada
K
K
Yamauchi
N
N
Imaki
T
T
Hotta
M
M
Demura
H
H
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001285:Atropine / Q000494:pharmacology; D002078:Butoxamine / Q000494:pharmacology; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018342:Receptors, Adrenergic, beta-1 / Q000187:drug effects / Q000502:physiology*; D012149:Restraint, Physical; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology / Q000503:physiopathology*; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*
D018342:Receptors, Adrenergic, beta-1; D002078:Butoxamine; D001285:Atropine; D003346:Corticotropin-Releasing Hormone; D011433:Propranolol; D008790:Metoprolol; D010424:Pentobarbital; D010646:Phentolamine