title: ETB receptor involvement in stimulatory and neurotoxic action of endothelin on dopamine neurones.
abstract: We examined the role of endothelin (ET) receptor subtypes in mediating the transient and sustained release of dopamine (DA) evoked by ETs and ET-1-induced dopaminergic dysfunction in rat striatal slices. Both phases of the release of DA evoked by ET-1 and ET-3 were inhibited by RES-701-1 (ETB antagonist) but not BQ-123 (ETA antagonist). The high K(+)-evoked DA release from slices remained impaired following a brief exposure to ET-1, under conditions of hypoxia/hypoglycaemia. RES-701-1 but not BQ-123 led to a recovery from ET-1-induced striatal dysfunction. Therefore, ETB receptors are involved in the stimulatory and neurotoxic actions of ETs on the striatal dopaminergic system.
authors.affiliation: Department of Pharmacology 2, Nagasaki University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kohzuma
authors.forename: Y
authors.initials: Y
authors.lastname: Kataoka
authors.forename: S
authors.initials: S
authors.lastname: Koizumi
authors.forename: H
authors.initials: H
authors.lastname: Shibaguchi
authors.forename: M N
authors.initials: MN
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Niwa
authors.forename: K
authors.initials: K
authors.lastname: Taniyama
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000187:drug effects; D004298:Dopamine / Q000502:physiology*; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D009498:Neurotoxins / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017466:Receptors, Endothelin / Q000145:classification / Q000502:physiology*
chemical_list: D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D009498:Neurotoxins; D010456:Peptides, Cyclic; D017466:Receptors, Endothelin; C087120:RES 701-1; C072247:cyclo(Trp-Asp-Pro-Val-Leu); D004298:Dopamine