Hypereosinophilia associated with monosomy 7.
Cytogenetic analysis of bone marrow cells from a patient with anemia, marked leukocytosis with eosinophilia, and thrombocytopenia showed monosomy 7 in all metaphases examined. The patient has refractory anemia (RA) according to FAB classification. Because of the hypereosinophilia of the patient, PCR technique was performed and no bcr-abl mRNA, specific for chronic myelogenous leukemia, was detected. Monosomy 7 has not been previously described in cases with hypereosinophilia. We assume, according to previous reports, that multiple genetic lesions can be involved in the pathogenesis of hypereosinophilia in this patient.
Viniou
N
N
First Department of Internal Medicine, University of Athens, Laikon Hospital, Greece.
Yataganas
X
X
Abazis
D
D
Paterakis
G
G
Vavourakis
S
S
Stamatopoulos
K
K
Matzourani
M
M
Loukopoulos
D
D
Pangalos
C
C
D000368:Aged; D000753:Anemia, Refractory / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002897:Chromosomes, Human, Pair 7; D004802:Eosinophilia / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D009006:Monosomy