title: Chronic myelomonocytic leukemia associated with primary amyloidosis.
abstract: A case of chronic myelomonocytic leukemia (CMML) associated with primary amyloidosis (AL) is presented. Hepatosplenomegaly, macroglossia, and xanthelasma were the major physical findings. Laboratory tests showed macrocytic anemia, thrombocytopenia, monocytosis and a bi-clonal gammopathy. Early monocytes and monoblasts were noted in the bone marrow aspiration biopsy. Cytogenetic evaluation showed a clonal deletion of chromosome 21 long arm (21q-). Amyloid was present in the liver, tongue and xanthelasma. In addition, the patient was noted to have osteosclerosis of the lower extremities. Treatment with prednisone and colchicine resulted in a subjective response. The unusual association of CMML, and primary amyloidosis is discussed.
authors.affiliation: Hematology Unit, Golda Medical Center, Petah-Tikva, Israel.
authors.forename: A M
authors.initials: AM
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Mittelman
authors.forename: R
authors.initials: R
authors.lastname: Gal
authors.forename: M
authors.initials: M
authors.lastname: Halperin
authors.forename: M
authors.initials: M
authors.lastname: Djaldetti
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications* / Q000235:genetics; D002872:Chromosome Deletion; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications* / Q000235:genetics