title: Self limited dermal invasion of keratinocytes in maculopapular eruptions after systemic chemotherapy.
abstract: Benign, multifocal, and transient (spontaneously disappearing within one month) stromal invasions of atypical basal keratinocytes were found in light and electron microscopic examination of maculopapular eruptions which developed after receiving an 8 day cycle of doxorubicin, 5-fluorouracil (5-FU), and cyclophosphamide (Cy) in a 63-year-old woman. She had had a modified radical mastectomy to remove a carcinoma of her right breast.
authors.affiliation: Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Hann
authors.forename: B S
authors.initials: BS
authors.lastname: Rhoe
authors.forename: W H
authors.initials: WH
authors.lastname: Kang
authors.forename: Y K
authors.initials: YK
authors.lastname: Park
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001485:Basement Membrane / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006818:Hyalin; D015603:Keratinocytes / Q000473:pathology*; D007633:Keratins; D008875:Middle Aged; D012867:Skin / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000473:pathology
chemical_list: C001500:keratohyalin; D007633:Keratins; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil