title: Comparative in-vitro activity of piperacillin-tazobactam against recent clinical isolates, a Dutch national multicentre study.
abstract: In this Dutch national survey piperacillin-tazobactam had a MIC90 of < or = 8 mg/L for Enterobacteriaceae (Enterobacter cloacae excluded) and Pseudomonas aeruginosa, 64 mg/L for E. cloacae, and 4 mg/L for Acinetobacter spp. The corresponding MIC90 values for piperacillin alone were < or = 256 mg/L, 256 mg/L, 16 mg/L and 32 mg/L. Only 15 of 93 piperacillin-tazobactam resistant E. cloacae strains were sensitive for ceftazidime, whereas 41 of 93 ceftazidime-resistant E. cloacae were sensitive to piperacillin-tazobactam.
authors.affiliation: University of Limburg, The Netherlands.
authors.forename: E E
authors.initials: EE
authors.lastname: Stobberingh
authors.forename: D M
authors.initials: DM
authors.lastname: Maclaren
authors.forename: P I
authors.initials: PI
authors.lastname: Schmitz
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D000077725:Piperacillin, Tazobactam Drug Combination
chemical_list: D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin