title: Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment.
abstract: Light (LM), transmission (TEM), and scanning (SEM) electron microscopy were used to characterize morphological changes induced in the gallbladder epithelium of female Syrian hamsters in response to one-month estradiol alone (E) and estradiol with medroxyprogesterone (E + MP) treatments. TEM data were correlated with the SEM observations. Compared with control (C), E- and E + MP-treated hamsters showed significant decreases in body weight, while the liver and gallbladder, and uterus weights increased. Moreover, E treatment induced some subcellular changes (microvilli, nucleus, mitochondria, RER, glycogen, abundant apical granules). The E + MP treatment appeared to exacerbate these similar changes and, in addition, induced apical excrescences and cell shedding. Both E and E + MP gallbladders showed luminal micelles, cellular debris and crystalliths associated with mucus. Simultaneously, an increased acidification of the mucoid content of the apical granules was noticed.
authors.affiliation: Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
authors.forename: S
authors.initials: S
authors.lastname: Karkare
authors.forename: T R
authors.initials: TR
authors.lastname: Kelly
authors.forename: J
authors.initials: J
authors.lastname: Gilloteaux
mesh_terms: D000818:Animals; D001835:Body Weight; D006224:Cricetinae; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D004958:Estradiol / Q000633:toxicity*; D005260:Female; D005704:Gallbladder / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008055:Lipids / Q000097:blood; D008525:Medroxyprogesterone / Q000633:toxicity*; D008647:Mesocricetus; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009929:Organ Size
chemical_list: D008055:Lipids; D004958:Estradiol; D008525:Medroxyprogesterone