A diterpene from Mikania obtusata active on Trypanosoma cruzi.
The diterpene ent-kaur-16-en-19-oic acid (1) was identified as the trypanocidal component of the ethanolic extract from Mikania obtusata D. C. (Asteraceae). This compound presents an IC50 of 0.5 mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis).
Alves
T M
TM
Chaves
P P
PP
Santos
L M
LM
Nagem
T J
TJ
Murta
S M
SM
Ceravolo
I P
IP
Romanha
A J
AJ
Zani
C L
CL
D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D051379:Mice; D010944:Plants / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D004224:Diterpenes; D014344:Trypanocidal Agents