High efficacy of short-term quinine-antibiotic combinations for treating adult malaria patients in an area in which malaria is hyperendemic.
In a randomized trial, a three-dose quinine monotherapy was compared with short-term combination regimens of quinine-clindamycin and quinine-doxycycline for treating adult Gabonese patients with Plasmodium falciparum malaria. In quinine-treated patients, only 38% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.
Metzger
W
W
International Research Laboratory, Albert-Schweitzer-Hospital, Lambaréné, Gabon.
Mordmüller
B
B
Graninger
W
W
Bienzle
U
U
Kremsner
P G
PG
D000293:Adolescent; D000328:Adult; D000368:Aged; D002981:Clindamycin / Q000008:administration & dosage*; D004318:Doxycycline / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005681:Gabon; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011803:Quinine / Q000008:administration & dosage*
D002981:Clindamycin; D011803:Quinine; D004318:Doxycycline