Olfactory neuroblastoma: clinical and pathological aspects.
Twenty cases of olfactory neuroblastoma were available for clinical and histopathological evaluation. The usefulness of immunohistochemistry in the diagnosis of this tumour was investigated and was best achieved using a panel of monoclonal and polyclonal antibodies, notably neuron-specific enolase, PGP 9.5, S-100 protein, synaptophysin and chromogranin A. This study confirmed that immunohistochemistry is a useful adjunct in cases where conventional histology is equivocal.
Lund
V J
VJ
Institute of Laryngology and Otology, London, United Kingdom.
Milroy
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D053379:Chromogranin A; D002864:Chromogranins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology* / Q000648:ultrastructure; D009669:Nose Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase; D009418:S100 Proteins; D013194:Staining and Labeling; D016708:Synaptophysin; D013869:Thiolester Hydrolases; D016896:Treatment Outcome; D043222:Ubiquitin Thiolesterase
D000911:Antibodies, Monoclonal; D053379:Chromogranin A; D002864:Chromogranins; D009418:S100 Proteins; D016708:Synaptophysin; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D010751:Phosphopyruvate Hydratase