Expression of the hepatocyte growth factor receptor in the regenerating rat liver.
The c-met oncogene product is a cell-surface receptor, which ligand is believed to be the hepatocyte growth factor. We studied the expression of c-met oncogene in the regenerating rat liver after either partial hepatectomy or CCl4-induced liver injury. Northern blot analysis showed that after partial hepatectomy the transcripts of c-met decreased at 8 h, reached the minimum at 36 h, and returned to the steady level on the seventh day. In contrast with the hepatectomized liver, the transcripts of c-met increased after CCl4 treatment. These observations suggest that c-met transcription may be regulated differently depending on regeneration signals.
Hoshino
Y
Y
Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Enomoto
N
N
Sakamoto
N
N
Kurosaki
M
M
Ikeda
T
T
Marumo
F
F
Sato
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002251:Carbon Tetrachloride / Q000008:administration & dosage; D006498:Hepatectomy; D008115:Liver Regeneration / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D019859:Proto-Oncogene Proteins c-met; D012313:RNA / Q000302:isolation & purification; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D011518:Proto-Oncogene Proteins; D012313:RNA; D002251:Carbon Tetrachloride; D019859:Proto-Oncogene Proteins c-met