Carcinoembryonic antigen isotypes in tissue sections and loose cyst fluid cells of ovarian neoplasms.
The aim of this study was to establish whether different subsets of ovarian neoplasms express a restricted isotype of carcinoembryonic antigen (CEA) which can be detected in solid tumors and detached cells. Sixty-one cases of mucinous, serous, endometrioid, and Krukenberg tumors were studied by immunohistochemistry using two monoclonal antibodies (MAbs), commercial anti-CEA and D14 with a higher specificity for colorectal adenocarcinomas. The results with both antibodies showed a considerable degree of heterogeneity between cases of nonserous tumors, with a more restrictive pattern observed with the D14 MAb. The proportion of immunostained cells was comparable in tumors and fluids.
Harłozińska
A
A
Department of Tumor Immunology, Silesian Piast's Medical Academy, Wrocław, Poland.
Bar
J K
JK
Jothy
S
S
Sedlaczek
P
P
Slesak
B
B
Richter
R
R
D000230:Adenocarcinoma / Q000276:immunology; D002288:Adenocarcinoma, Mucinous / Q000276:immunology; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001202:Ascitic Fluid / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D003536:Cystadenocarcinoma / Q000276:immunology; D003537:Cystadenoma / Q000276:immunology; D004715:Endometriosis / Q000276:immunology; D000939:Epitopes; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007725:Krukenberg Tumor / Q000276:immunology; D010051:Ovarian Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D000939:Epitopes