[Changes in the granuloma in the experimental treatment of tuberculosis with a prolonged form of isoniazid].
The main difficulties encountered in the treatment of the persistent forms of a chronic tuberculous process are associated with a difficult access to mycobacteria persisting in the vacuolar apparatus of macrophages that form granulomas as well as with a high level of toxic affections of the parenchymatous liver cells. The complex long-acting isoniazid preparation on the dextran basis and the scheme of its application prevented, to a considerable degree, the above complications under the experimental conditions and hence can be considered as promising for clinical use.
Shkurupiĭ
V A
VA
Chernova
T G
TG
Kurunov
Iu N
IuN
D000818:Animals; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D003911:Dextrans / Q000493:pharmacokinetics / Q000627:therapeutic use; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D007538:Isoniazid / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D014375:Tuberculoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014386:Tuberculosis, Hepatic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D003692:Delayed-Action Preparations; D003911:Dextrans; D004338:Drug Combinations; D007538:Isoniazid