Serum concentrations of G-CSF during high-dose chemotherapy with autologous stem cell rescue.
In 20 patients treated for refractory germ cell tumors, endogenous G-CSF levels were monitored before and after high-dose chemotherapy with autologous stem cell rescue (ASCR). An inverse relationship was found between endogenous G-CSF levels and peripheral blood leucocyte counts. G-CSF levels were not detectable prior to ASCR, but increased to a maximum of 3400 pg/ml (range 120-15000 pg/ml) thereafter. There was no relationship between peak G-CSF levels and time to engraftment. A decrease in G-CSF levels preceded engraftment and was paralleled by a rise of nadir leucocyte counts.
Miksits
K
K
Institut für Medizinische Mikrobiologie, Freien Universität Berlin, Germany.
Beyer
J
J
Siegert
W
W
D000328:Adult; D001772:Blood Cell Count; D003131:Combined Modality Therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood* / Q000188:drug therapy; D012189:Retrospective Studies
D016179:Granulocyte Colony-Stimulating Factor