Flupirtine protects against ischaemic retinal dysfunction in rats.
The present study investigated whether flupirtine attenuates the depression and enhances the recovery of the b-wave of the electroretinogram (ERG) in response to retinal ischaemia. The ERG was recorded from pentobarbital-anaesthetized rats before, during and after transient (24 min) occlusion of both common carotid arteries. Flupirtine administered 20 min before ischaemia reduced the depression of the b-wave during occlusion and accelerated recovery during reperfusion. When given at the onset of ischaemia flupirtine led to attenuation of the reduction of the b-wave during occlusion and to enhancement of the recovery during reperfusion. The present results suggest that flupirtine provides protection against ischaemic retinal dysfunction.
Block
F
F
Department of Neurology, University of Essen, Germany.
Pergande
G
G
Schwarz
M
M
D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D004596:Electroretinography; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D015424:Reperfusion; D012171:Retinal Vessels
D000631:Aminopyridines; C034161:flupirtine