[IGFBP3 in the assessment of growth hormone defects].
Evaluation of growth hormone dependent IGFBP3, stable in time and with no circadian variations is a useful parameter for diagnosing growth hormone deficit. The IGFBP3 was evaluated using sera, collected and kept at -20 degrees C, from subjects classified according to auxologic characters and response sup. or inf. to 8 ng/ml GH after two stimulation tests and median nocturnal GH sup. or inf. to 3 ng/ml. Two groups were studied: 1) Small stature GHD (growth hormone deficiency): 14 cases; 2) Constitutional small stature (RCC,BSF): 12 cases. A third group composed of 8 normal height, weight and disease-free children formed the control group. The IGFBP3 values were below the 5th percentile in 86% of GHD cases, between the 5th and 95th percentile in 66.6% of constitutionally short stature children and in all normal controls was about the 50th percentile. The IGFBP3 also shows a statistically significant correlation between median nocturnal GH, both in deficient and constitutionally short stature groups (p < 0.01).
Sposito
M
M
Istituto di Pediatria, Università di Perugia, Italia.
Truffarelli
F
F
Sabalich
I
I
De Giorgi
G
G
Cova
L
L
Britta
R
R
Rufini
S
S
D000293:Adolescent; D002352:Carrier Proteins / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D008297:Male; D012016:Reference Values; D012044:Regression Analysis; D013002:Somatomedins / Q000032:analysis*
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D013006:Growth Hormone