[Cytokines and solid tumors].
Various cytokines can be used in the treatment of solid tumours. They are factors of proliferation and/or differentiation of haematopoiesis or immunopoiesis, and they stimulate the effector cells of anti-tumoral response. The various steps in the preclinical and clinical development of a cytokine in the field of oncology are detailed, taking IL-2 as an example. The results of the clinical trials reported (essentially with INF and IL-2) are presented and discussed.
Triebel
F
F
Service d'hémato-immunologie, INSERM U 333, Institut Gustave-Roussy, Villejuif.
Escudier
B
B
D016207:Cytokines / Q000145:classification / Q000627:therapeutic use*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*
D016207:Cytokines; D007376:Interleukin-2; D007372:Interferons