title: Prognostic factors in mucoepidermoid carcinomas of major salivary glands: a clinicopathologic and flow cytometric study.
abstract: Mucoepidermoid carcinomas (MEC) of the major salivary glands from 48 patients who received their treatment at a single institution were studied for prognostic indicators. Uni- and multivariate statistical analyses were performed on several clinicopathologic factors and also on flow cytometric (FCM) DNA content data of the carcinomas. Clinical prognostic factors associated with decreased survival included age > 60 years (P = 0.01), male gender (P = 0.002), symptoms at diagnosis (P = 0.03), stage of disease (P < or = 0.0001), type of surgery (P = 0.0006), and recurrence (P = 0.0001). Histopathological prognostic factors associated with decreased survival included MEC tumour grade (P = 0.0001), tumour size > 3.0 cm (P = 0.02), lymph node involvement (P = 0.0004) and positive surgical margins (P = 0.007). DNA FCM factors associated with decreased survival included aneuploid tumours (P = 0.08) and proliferative activity (S+G2M > 5%, P = 0.07). Multivariate analysis indicated that histological grade, proliferative activity, symptoms at diagnosis, clinical stage of disease and type of surgery were significant (P < or = 0.05) prognostic/survival factors in the biological assessment of this neoplasm.
authors.affiliation: Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hicks
authors.forename: A K
authors.initials: AK
authors.lastname: el-Naggar
authors.forename: R M
authors.initials: RM
authors.lastname: Byers
authors.forename: C M
authors.initials: CM
authors.lastname: Flaitz
authors.forename: M A
authors.initials: MA
authors.lastname: Luna
authors.forename: J G
authors.initials: JG
authors.lastname: Batsakis
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000782:Aneuploidy; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics / Q000473:pathology*; D002648:Child; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000473:pathology*; D012737:Sex Factors
chemical_list: D004273:DNA, Neoplasm