title: Circadian variation in plasma 5-hydroxyindoleacetic acid level during and after alcohol withdrawal: phase advances in alcoholic patients compared with normal subjects.
abstract: Alcohol withdrawal symptoms in 19 male alcoholics were objectively evaluated and classified and circadian variation in their plasma 5-hydroxyindoleacetic acid (5-HIAA) concentrations was determined at 3 different intervals after cessation of drinking. Circadian variations in plasma 5-HIAA level exhibited phase advances in alcoholic patients compared with normal controls and were different depending on the severity of alcohol withdrawal symptoms. Plasma 5-HIAA in patients with delirium tremens showed significantly higher levels during the abstention period, possibly suggesting peculiarity in their serotonergic metabolism.
authors.affiliation: Department of Psychiatry, Hamamatsu University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sano
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: R
authors.initials: R
authors.lastname: Yazaki
authors.forename: K
authors.initials: K
authors.lastname: Tamefusa
authors.forename: K
authors.initials: K
authors.lastname: Ohara
authors.forename: T
authors.initials: T
authors.lastname: Yokoyama
authors.forename: K
authors.initials: K
authors.lastname: Miyasato
authors.forename: K
authors.initials: K
authors.lastname: Ohara
mesh_terms: D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000097:blood*; D000437:Alcoholism / Q000097:blood / Q000534:rehabilitation*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D006897:Hydroxyindoleacetic Acid