Anti-gammaglobulin factors in human sera revealed by enzymatic splitting of anti-Rh antibodies. Vox Sang 1963;8:133-52.
Human sera were found that contained antibody activity which caused agglutination of red cells or particles sensitized with immunoglobulin G that had first been degraded by pepsin proteolysis. The agglutinating activity was specific for a determinant that was not present on the untreated, native immunoglobulin. It was found most frequently in sera from rheumatoid arthritis patients and its titre showed some correlation with disease activity.
Osterland
C K
CK
Harboe
M
M
Kunkel
H G
HG
D000939:Epitopes; D049673:History, 20th Century; D006801:Humans; D012204:Rh-Hr Blood-Group System; D012217:Rheumatoid Factor
D000939:Epitopes; D012204:Rh-Hr Blood-Group System; D012217:Rheumatoid Factor