[Anti-ulcerogenic properties of psychostimulants of the phenylalkylsydnone imine series].
In rats, administration of 96% ethanol to the stomach causes ulcerative damages to its mucosa just 8 minutes later, which are of significant dimensions, reaching their maximum size following 3 hours. The sydnonimine psychostimulant OF-743 in combination with ethanol substantially reduces mucosal damage. The use of ethanol after OF-743 injections results in less ulcerative damage. The findings suggest that the drug has not only protective (preventive) effects, but beneficial properties.
Samonina
G E
GE
Natsvlishvili
N A
NA
Ashmarin
I P
IP
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D051381:Rats; D013558:Sydnones / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D000928:Antidepressive Agents; D013558:Sydnones; C072808:OF 743