title: Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist.
abstract: The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neuromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: E E
authors.initials: EE
authors.lastname: Ladenheim
authors.forename: J E
authors.initials: JE
authors.lastname: Taylor
authors.forename: D H
authors.initials: DH
authors.lastname: Coy
authors.forename: T H
authors.initials: TH
authors.lastname: Moran
mesh_terms: D000818:Animals; D001483:Base Sequence; D001839:Bombesin / Q000378:metabolism; D004435:Eating / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D015287:Neurokinin B / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010446:Peptide Fragments / Q000378:metabolism; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C092829:BIM 23127; D010446:Peptide Fragments; D010456:Peptides, Cyclic; C040794:neuromedin C; D015287:Neurokinin B; C038393:neuromedin B; D005947:Glucose; D001839:Bombesin