Single topical application of human recombinant basic fibroblast growth factor (rbFGF) promotes neovascularization in rat cerebral cortex.
Basic fibroblast growth factor (bFGF) is a morphogenic, chemotactic, mitogenic, and angiogenic peptide found within the central nervous system (CNS) with potent neurotrophic effects. A potential role in ischemia-induced vascular growth has been suggested for bFGF. In this study, we show that single, topical administration of human recombinant basic fibroblast growth factor (rbFGF) in the rat cerebral cortex promotes capillary overgrowth and might mimic the angiogenic response observed after brain ischemia. The implication of this finding for the therapeutic use of basic FGF in angiogenic therapy is discussed.
Cuevas
P
P
Servicio de Histología, Hospital Ramón y Cajal, Madrid, Spain.
Giménez-Gallego
G
G
Carceller
F
F
Cuevas
B
B
Crespo
A
A
D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar
D016222:Fibroblast Growth Factor 2