title: Molecular mechanics of nucleic acid sequence amplification.
abstract: Protocols for in vitro amplification of nucleic acids are proliferating and there are now several methods that will contribute both to genetic research and to the diagnosis of a wide range of diseases. Here, I present the working principles of some of these molecular machines for amplifying DNA or RNA and discuss the lines along which new methods of amplifying nucleic acids may be developed.
authors.affiliation: Department of Medical Genetics, Uppsala Biomedical Center, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Landegren
mesh_terms: D004247:DNA / Q000032:analysis / Q000096:biosynthesis*; D004261:DNA Replication; D021141:Nucleic Acid Amplification Techniques; D012313:RNA / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D012313:RNA; D004247:DNA