[The pharmacokinetic modification of mutagenesis].
The mutagenic activity of some antitumor agents and the antituberculous agent isoniazid was studied by using some methods for estimating mutations on the Drosophila, mammals, and human cells. It was shown that mutagenic effects could be modified by adding various auxiliaries to the formulations of the drugs. The mechanisms of modifications were examined by pharmacokinetic techniques.
Revazova
Iu A
IuA
Bratslavskiĭ
V A
VA
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D001388:Aziridines / Q000493:pharmacokinetics / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D004331:Drosophila melanogaster; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016296:Mutagenesis / Q000187:drug effects*; D011205:Povidone; D011687:Purines / Q000493:pharmacokinetics / Q000494:pharmacology; D012996:Solutions; D013852:Thiotepa / Q000493:pharmacokinetics / Q000494:pharmacology
D000970:Antineoplastic Agents; D001388:Aziridines; D011687:Purines; D012996:Solutions; C007779:fotrin; C015893:pumitepa; D013852:Thiotepa; D011205:Povidone