title: Predictive factors for the rate of engraftment of neuroblastoma patients autotransplanted with purged marrow.
abstract: Predictive values for patient engraftment in neuroblastoma have not been defined. By analyzing the parameters available to us at the time of harvest and post-harvest, we found that the MNC/kg after purging demonstrated significant correlation with patient engraftment as measured by the patient's time to reach a WBC count of 1,000/microL and an ANC count of 500/microL. Platelet and red cell independence was difficult to measure as some of these patients remain platelet- and red cell-dependent for extended periods of time. Platelet refractoriness, alloimmunization, infection and many other factors can delay platelet and red cell recovery following transplantation. A larger number of patients is needed to assess a correlation between the parameters analyzed and platelet and red cell recovery, as well as to validate our observation with myeloid recovery.
authors.affiliation: Department of Pathology, Medical University of South Carolina, Charleston.
authors.forename: R E
authors.initials: RE
authors.lastname: Ross
authors.forename: E K
authors.initials: EK
authors.lastname: Jeter
authors.forename: Y
authors.initials: Y
authors.lastname: Gazitt
authors.forename: J
authors.initials: J
authors.lastname: Laver
mesh_terms: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D016465:Bone Marrow Purging / Q000379:methods; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003114:Colony-Forming Units Assay; D006801:Humans; D018189:Immunomagnetic Separation; D007958:Leukocyte Count; D009447:Neuroblastoma / Q000097:blood / Q000628:therapy*; D014182:Transplantation, Autologous
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm