title: Ascorbic acid stimulation of gonadotropin release from hamster anterior pituitary gland is not mediated through cyclic nucleotide system.
abstract: Ascorbic acid (AA) can transiently stimulate LH and FSH release from superfused male hamster anterior pituitary glands. The effective concentration is 1 mM or higher. Since 8-Br-cAMP or 8-Br-cGMP can not mimic the AA stimulation pattern, the action mechanism is not mediated through cyclic nucleotide system.
authors.affiliation: Department of Reproductive Medicine and Biology, University of Texas Medical School at Houston 77025.
authors.forename: W S
authors.initials: WS
authors.lastname: Wun
authors.forename: A S
authors.initials: AS
authors.lastname: Berkowitz
authors.forename: J P
authors.initials: JP
authors.lastname: Preslock
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D006224:Cricetinae; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*
chemical_list: D006062:Gonadotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D006152:Cyclic GMP; D001205:Ascorbic Acid