[The participation of the brain dopamine receptors in the functional alteration of the hypothalamo-hypophyseal-adrenal cortex system in rat progeny that received alcohol with the maternal milk].
The rat experiments have shown that cerucal-induced blockade of dopamine receptors in the brain normalizes hypothalamo-hypophyseo-adrenocortical parameters in the early postnatal period in newborn rats alcoholized during lactation, as well as reduces the functional activity of the links in this system in the formation of sexual maturity and early puberty. It is suggested that dopamine might play a significant role in the mechanism of action of alcohol through its receptors on the rat offsprings' hypothalamo_hypophyseo-adrenocortical system.
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D015062:11-Hydroxycorticosteroids / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000818:Animals; D000833:Animals, Suckling; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000032:analysis; D000431:Ethanol / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000502:physiology; D007031:Hypothalamus / Q000737:chemistry; D007774:Lactation / Q000187:drug effects* / Q000502:physiology; D008787:Metoclopramide / Q000494:pharmacology; D010902:Pituitary Gland / Q000737:chemistry; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology
D015062:11-Hydroxycorticosteroids; D011954:Receptors, Dopamine; D000431:Ethanol; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D008787:Metoclopramide