Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties.
Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 microM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.
Sud'ina
G F
GF
A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russian Federation.
Mirzoeva
O K
OK
Pushkareva
M A
MA
Korshunova
G A
GA
Sumbatyan
N V
NV
Varfolomeev
S D
SD
D000975:Antioxidants / Q000494:pharmacology*; D002109:Caffeic Acids / Q000494:pharmacology*; D001467:Hordeum / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
D000975:Antioxidants; D002109:Caffeic Acids; D008041:Linoleic Acids; D016859:Lipoxygenase Inhibitors; D017382:Reactive Oxygen Species; D014970:Xanthines; D019820:Xanthine; D019787:Linoleic Acid; D014969:Xanthine Oxidase; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; C040048:caffeic acid