title: Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridization.
abstract: Fluorescence in situ hybridization (FISH) was performed on bone marrow or peripheral blood cells thought to contain a del(11)(q23q25) from four patients who had acute leukemia or myelodysplasia. Cells from all patients were shown to contain translocations that involved chromosome 6 in three of them. Our data suggest that a large proportion of presumptive del(11)(q23) or del(11)(q23q25) chromosomes may represent previously unidentified translocations that can be detected by FISH.
authors.affiliation: Department of Medicine, University of Chicago, Illinois 60637.
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: R
authors.initials: R
authors.lastname: Espinosa
authors.forename: M J
authors.initials: MJ
authors.lastname: Thirman
authors.forename: A A
authors.initials: AA
authors.lastname: Fernald
authors.forename: K
authors.initials: K
authors.lastname: Shannon
authors.forename: M O
authors.initials: MO
authors.lastname: Diaz
authors.forename: M M
authors.initials: MM
authors.lastname: Le Beau
authors.forename: J D
authors.initials: JD
authors.lastname: Rowley
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics; D014178:Translocation, Genetic