Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies.
Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies reporting measurement of circulating ICAM-1. Soluble ICAM-1 and VCAM-1 levels were significantly higher in all the patient groups compared with the controls whereas soluble E-selectin was significantly higher in the ovarian, breast and GI cancer groups and lower in the myeloma group. The significance of these results together with the possible sources and stimuli for release of these adhesion molecules are discussed.
Banks
R E
RE
Yorkshire Cancer Research Campaign Institute for Cancer Studies, Department of Clinical Medicine, University of Leeds, St. James's University Hospital, UK.
Gearing
A J
AJ
Hemingway
I K
IK
Norfolk
D R
DR
Perren
T J
TJ
Selby
P J
PJ
D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D019040:E-Selectin; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000097:blood; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007680:Kidney Neoplasms / Q000097:blood; D008223:Lymphoma / Q000097:blood; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood; D009369:Neoplasms / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood; D012016:Reference Values; D001749:Urinary Bladder Neoplasms / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1