Study on pharmacological effect of bile salts, sodium scymnol sulfate, from Rhizoprionodon acutus. I. Effect of scymnol, chimaerol and sodium scymnol sulfate on cerebral anoxia.
The effects of scymnol, chimaerol and sodium scymnol sulfate, prepared from the bile of Rhizoprionodon acutus, on cerebral anoxia were investigated in experimental models of hypoxia, ischemia and histotoxic anoxia in mice. Scymnol, at a dose of 100 mg/kg, showed a significant protective action against cerebral anoxia in all of the models studied and significantly increased the partial oxygen pressure of the arterial blood. The anti-anoxic activity of scymnol was found to be slightly greater than that of idevenone. A similar protective effect of sodium scymnol sulfate was seen at doses higher than 100 mg/kg. The survival time on hypoxia was significantly prolonged in the animals pretreated with chimaerol.
Ishida
H
H
School of Pharmaceutical Science, University of Shizuoka, Japan.
Kinoshita
S
S
Yamamoto
N
N
Nukaya
H
H
Tsuji
K
K
Kosuge
T
T
D000818:Animals; D001274:Atmospheric Pressure; D001646:Bile / Q000737:chemistry; D001647:Bile Acids and Salts / Q000494:pharmacology*; D001784:Blood Gas Analysis; D002777:Cholestanols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002534:Hypoxia, Brain / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008419:Materia Medica; D051379:Mice; D008815:Mice, Inbred Strains; D011190:Potassium Cyanide; D012754:Sharks / Q000378:metabolism
D001647:Bile Acids and Salts; D002777:Cholestanols; D008419:Materia Medica; C092641:chimaerol; C059448:scymnol sulfate ester; C074469:scymnol; D011190:Potassium Cyanide