title: Melatonin signal transduction in the goldfish, Carassius auratus.
abstract: Generation and reception of melatonin signals in the goldfish, Carassius auratus, are reviewed. The photoreceptive pineal gland of the goldfish generates circulating melatonin rhythms according to a given photoperiod under light-dark cycles and in a circadian manner under continuous dark conditions. Melatonin is also produced in the retina in a similar fashion. Melatonin produced in the pineal gland and retina is considered to act as internal zeitgeber in the brain and retina, respectively, controlling various physiological events via specific melatonin binding sites that are coupled with G protein. The goldfish exhibit clear diurnal locomotor activity rhythms under light-dark cycles and free-running rhythms under constant conditions. However, the relationship between melatonin and locomotor activity rhythms in the goldfish remains unclear. Further studies should be required to demonstrate the roles of melatonin in the circadian system in this species.
authors.affiliation: Department of Anatomy, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iigo
authors.forename: H
authors.initials: H
authors.lastname: Kezuka
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Tabata
authors.forename: K
authors.initials: K
authors.lastname: Aida
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D006054:Goldfish / Q000502:physiology*; D008550:Melatonin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D008550:Melatonin