title: Evaluation of regional cerebral blood flow in massive intracerebral calcifications.
abstract: Fahr's disease is histopathologically characterized by massive bilateral calcifications of the cerebral basal ganglia, the dentate nuclei of the cerebellum and both the cerebral and cerebellar cortices. We report a case of Fahr's disease in which a 99mTc-hexamethyl-propylenamine oxime (99mTc-HMPAO) brain SPECT study was used to evaluate regional cerebral blood flow to the calcified regions. There was markedly decreased perfusion to the basal ganglia bilaterally as well as decreased perfusion to the cerebral cortices that correlated well with the patient's clinical condition.
authors.affiliation: Department of Radiology, Medical College of Wisconsin, Milwaukee 53226, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Uygur
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: R S
authors.initials: RS
authors.lastname: Hellman
authors.forename: R S
authors.initials: RS
authors.lastname: Tikofsky
authors.forename: B D
authors.initials: BD
authors.lastname: Collier
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging*; D001921:Brain / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging*; D002529:Cerebellar Nuclei / Q000000981:diagnostic imaging; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime