Comparison of iopamidol and ioversol in vitro and in animal studies.
In the present series of studies we investigated differences in vitro and in animal experiments between iopamidol (Iopamiron, CAS 60166-93-0) and ioversol (CAS 87771-40-2). The studies included the in vitro investigations partition coefficient, lysozyme inhibition, coagulation time and erythrocyte morphology as well as the in vivo paradigms acute toxicity, neural toxicity, general behavior/locomotor activity and angiography. Iopamidol was superior to ioversol in most of the tests. In spite of its higher hydrophilicity, ioversol did not show improved tolerance in comparison to iopamidol.
Krause
W
W
Research Laboratories of Schering Aktiengesellschaft, Berlin, Germany.
Miyazawa
T
T
Uchimoto
R
R
Murayama
C
C
Fritz-Zieroth
B
B
Press
W R
WR
Frenzel
T
T
D000792:Angiography; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D066298:In Vitro Techniques; D007479:Iopamidol / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009113:Muramidase / Q000037:antagonists & inhibitors; D009422:Nervous System Diseases / Q000139:chemically induced; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014283:Triiodobenzoic Acids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D014914:Whole Blood Coagulation Time
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D009113:Muramidase; D007479:Iopamidol; C054871:ioversol