Effect of low-dose cyclosporin on plasma lipoproteins and markers of cholestasis in patients with psoriasis.
The benefits of using cyclosporin in organ transplantation to prevent graft rejection outweigh its potential disadvantages, but with the use of low-dose cyclosporin in relatively healthy individuals, such as those with psoriasis, the risk:benefit ratio is altered. The effects of low-dose cyclosporin (< 5 mg/kg body weight) on liver function and serum lipids and lipoproteins were examined in 40 normolipidaemic, normotensive psoriasis patients with normal renal function. After 3 months of treatment, serum cholesterol and bilirubin concentrations and alkaline phosphatase activity increased significantly (p = 0.001), and glomerular filtration rate (GFR) declined from 107 to 96 ml/min/1.73 m2 (p = 0.05). All these values returned to pretreatment levels 3 months after cessation of cyclosporin. In 15 patients in whom lipoproteins were isolated by ultracentrifugation, there was an increase in plasma low-density lipoprotein (LDL) cholesterol (p = 0.05), but very-low-density lipoprotein cholesterol, high-density lipoprotein (HDL) and HDL2 and HDL3 cholesterol concentrations did not change. The increases in serum bilirubin, alkaline phosphatase activity and LDL cholesterol, seen in individuals with normal baseline liver and renal function, which reverted to baseline following cessation of cyclosporin, suggest that cyclosporin-induced hypercholesterolaemia may be due to either decreased biliary excretion of cholesterol or impaired catabolism of LDL.
Edwards
B D
BD
University Department of Medicine, Manchester Royal Infirmary.
Bhatnagar
D
D
Mackness
M I
MI
Gokal
R
R
Ballardie
F W
FW
Chalmers
R J
RJ
Durrington
P N
PN
D015415:Biomarkers / Q000097:blood; D002779:Cholestasis / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008111:Liver Function Tests; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy
D015415:Biomarkers; D008078:Cholesterol, LDL; D008074:Lipoproteins; D016572:Cyclosporine