title: MIF, a previously unrecognized pituitary hormone and macrophage cytokine, is a pivotal mediator in endotoxic shock.
abstract: Recent studies have led to the re-discovery of the protein originally described as macrophage-migration inhibitory factor (MIF) to be both a pituitary hormone and a pro-inflammatory, macrophage cytokine. MIF is a pivotal mediator in endotoxic shock and may serve as a pituitary "stress" hormone that regulates systemic inflammatory responses.
authors.affiliation: Picower Institute for Medical Research, New York.
authors.forename: R
authors.initials: R
authors.lastname: Bucala
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D010907:Pituitary Hormones / Q000502:physiology*; D012772:Shock, Septic / Q000503:physiopathology*
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D010907:Pituitary Hormones