The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats.
The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation behavior was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.
Mintz
M
M
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Gordon
I
I
Roz
N
N
Rehavi
M
M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001692:Biological Transport; D002352:Carrier Proteins / Q000187:drug effects* / Q000502:physiology; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D050483:Dopamine Plasma Membrane Transport Proteins; D004334:Drug Administration Schedule; D005260:Female; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects*; D009419:Nerve Tissue Proteins; D051381:Rats; D017208:Rats, Wistar
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D003913:Dextroamphetamine