title: Multideterminant role of calcium in hippocampal synaptic plasticity.
abstract: Hippocampal CA1 cells possess several varieties of long-lasting synaptic plasticity: two different forms of long-term potentiation (LTP) and at least one form of long-term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca2+ influx, all can be blocked by Ca2+ chelators, and all activate Ca(2+)-dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage-dependent differences in cytosolic Ca2+ concentration acting upon Ca2+ substrates of differing Ca2+ affinities and compartmentalization of the Ca2+ and its substrates.
authors.affiliation: Neurobiology Department, Northeastern Ohio College of Medicine, Rootstown 44272-0095.
authors.forename: T J
authors.initials: TJ
authors.lastname: Teyler
authors.forename: I
authors.initials: I
authors.lastname: Cavus
authors.forename: C
authors.initials: C
authors.lastname: Coussens
authors.forename: P
authors.initials: P
authors.lastname: DiScenna
authors.forename: L
authors.initials: L
authors.lastname: Grover
authors.forename: Y P
authors.initials: YP
authors.lastname: Lee
authors.forename: Z
authors.initials: Z
authors.lastname: Little
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
chemical_list: D002118:Calcium