title: [Anti-ulcerogenic properties of psychostimulants of the phenylalkylsydnone imine series].
abstract: In rats, administration of 96% ethanol to the stomach causes ulcerative damages to its mucosa just 8 minutes later, which are of significant dimensions, reaching their maximum size following 3 hours. The sydnonimine psychostimulant OF-743 in combination with ethanol substantially reduces mucosal damage. The use of ethanol after OF-743 injections results in less ulcerative damage. The findings suggest that the drug has not only protective (preventive) effects, but beneficial properties.
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: N A
authors.initials: NA
authors.lastname: Natsvlishvili
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D051381:Rats; D013558:Sydnones / Q000494:pharmacology*
chemical_list: D000897:Anti-Ulcer Agents; D000928:Antidepressive Agents; D013558:Sydnones; C072808:OF 743