Alteration of glucose tolerance in mice fed low levels of aflatoxins and with depressed glyoxalase-I activity.
Glyoxalase-I activity plays an important role in glucose metabolism and has been reported to be depressed in mice fed low levels of aflatoxin B1. In the present study examination of glyoxalase-I activity, glucose tolerance and pancreatic beta cell sensitivity was made in mice fed 0.045 ng aflatoxin B1 + 0.450 ng aflatoxin G1/g feed prenatally and for 6 mo after birth. After glucose challenge the ratios between 0-h and 2-h serum glucose levels were significantly higher than controls, indicating an increase in tolerance of glucose in the aflatoxin-fed mice with lower glyoxalase-I activity. Pancreatic beta cell sensitivity to stimulation by tolbutamide was similar in both groups. However, liver malonic dialdehyde was significantly higher in the aflatoxin-fed mice, suggesting that the altered tolerance for glucose in the aflatoxin-fed mice might be a consequence of aflatoxin mediated peroxidative actions in the liver.
Ankrah
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Noguchi Memorial Institute for Medical Research, University of Ghana, Legon.
D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D007515:Islets of Langerhans / Q000187:drug effects; D007791:Lactoylglutathione Lyase / Q000172:deficiency / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D017392:Thiobarbituric Acid Reactive Substances; D014044:Tolbutamide / Q000494:pharmacology
D000348:Aflatoxins; D001786:Blood Glucose; D017392:Thiobarbituric Acid Reactive Substances; D014044:Tolbutamide; D007791:Lactoylglutathione Lyase