The analgesia induced by intrathecal injection of ruthenium red.
Intrathecally (i.t.) administered ruthenium red (40, 80, 160 ng) dose-dependently inhibited formalin-induced nociceptive response. Ruthenium red caused a significant inhibition of pain-related behavioral responses induced by i.t. capsaicin but not by i.t. substance P. These results suggest that ruthenium red produces analgesia by inhibiting the release of neuropeptides in the spinal cord.
Ohkubo
Tsuyako
T
Department of Pharmacology, Fukuoka Dental College, 700 Ta, Sawara-ku, Fukuoka 814-01 Japan.
Shibata
Manabu
M
Takahashi
Hiroshi
H
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002211:Capsaicin; D005557:Formaldehyde; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement / Q000187:drug effects; D012430:Ruthenium Red / Q000008:administration & dosage / Q000494:pharmacology*; D013373:Substance P
D000700:Analgesics; D012430:Ruthenium Red; D005557:Formaldehyde; D013373:Substance P; D002211:Capsaicin