title: The pharmacokinetics of once daily gentamicin in neutropenic adults with haematological malignancy.
abstract: Seven febrile neutropenic adults with normal renal function were treated with intravenous gentamicin 4.5 mg/kg once a day in combination with azlocillin. Gentamicin serum concentrations 1, 2, 4, 8, and 24 h after a 30 min infusion were 10.9 +/- 0.6, 7.1 +/- 0.4, 4.2 +/- 0.2, 1.8 +/- 0.1 and 0.16 +/- 0.003 mg/L respectively. The pharmacokinetics were best described by a triphasic plot including a distribution phase (about 1/2 h) and two elimination phases, an early and late.
authors.affiliation: Department of Medical Microbiology, Southmead Health Services NHS Trust, Westbury-on-Trym, Bristol, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: MacGowan
authors.forename: K A
authors.initials: KA
authors.lastname: Bedford
authors.forename: E
authors.initials: E
authors.lastname: Blundell
authors.forename: N M
authors.initials: NM
authors.lastname: Brown
authors.forename: F
authors.initials: F
authors.lastname: Habib
authors.forename: J
authors.initials: J
authors.lastname: Hows
authors.forename: B
authors.initials: B
authors.lastname: Kirkpatrick
authors.forename: R J
authors.initials: RJ
authors.lastname: Korner
authors.forename: R R
authors.initials: RR
authors.lastname: Slade
authors.forename: L O
authors.initials: LO
authors.lastname: White
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001390:Azlocillin / Q000008:administration & dosage; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D005839:Gentamicins; D001390:Azlocillin