A comparative study of delayed neurotoxicity in hens following repeated administration of organophosphorus compounds.
Hens treated with Mipafox (10 mg/kg, sc), sarin (50 micrograms/kg, sc) or parathion (1 mg/kg, sc) daily for 10 days exhibited severe, moderate and no ataxia respectively on 14th day after the start of exposure. The neurotoxic esterase (NTE) activity was significantly inhibited in the brain, spinal cord and platelets of hens treated with mipafox or sarin whereas no change was noticed with parathion treatment. All three compounds significantly inhibited acetylcholinesterase (AChE) activity in the platelets. Spinal cord of hens treated with mipafox, sarin or parathion showed axonal degeneration heavy, moderate and none respectively. It is concluded that repeated administration of equitoxic doses of mipafox, sarin and parathion to hens are marked, moderate and non-delayed neurotoxic respectively.
Husain
K
K
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior.
Pant
S C
SC
Raza
S K
SK
Singh
R
R
Das Gupta
S
S
D000818:Animals; D001259:Ataxia / Q000139:chemically induced*; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors / Q000097:blood; D002490:Central Nervous System / Q000187:drug effects* / Q000201:enzymology; D002645:Chickens; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D005260:Female; D007531:Isoflurophate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D010278:Parathion / Q000008:administration & dosage / Q000633:toxicity*; D012524:Sarin / Q000008:administration & dosage / Q000633:toxicity*; D013116:Spinal Cord / Q000187:drug effects / Q000201:enzymology; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D007531:Isoflurophate; C005238:mipafox; D010278:Parathion; D012524:Sarin; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase