title: Endothelialization of anastomoses in the aorta and inferior vena cava of the rat.
abstract: Denuding endothelial damage at anastomoses may lead to thrombotic complications and failure of microvascular reconstructions. Confluent endothelial healing at anastomoses may reduce thrombotic and other complications. The progress of endothelial coverage of anastomotic structures in the aorta and inferior vena cava (IVC) of the rat was evaluated at 3, 5, 8, 11, and 14 days after completion of the anastomoses, by means of scanning electron microscopy. Arterial anastomotic patency was 100%; venous patency was 84%. It was found that endothelial healing progressed towards thin confluent coverage first, thereafter thickening. Coverage was first achieved at the needle defect, then the anastomotic junction, and lastly the suture. The same stage of endothelial coverage of anastomotic structures was reached 5 to 8 days sooner at the IVC anastomosis than in the aorta.
authors.affiliation: Department of Surgery, University of Lund, Sweden.
authors.forename: B J
authors.initials: BJ
authors.lastname: Sigurbjörnsson
authors.forename: E
authors.initials: E
authors.lastname: Hallberg
authors.forename: A
authors.initials: A
authors.lastname: Andrén-Sandberg
authors.forename: E
authors.initials: E
authors.lastname: Ribbe
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001011:Aorta / Q000502:physiology / Q000601:surgery* / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000502:physiology* / Q000648:ultrastructure; D006439:Hemodynamics; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017207:Rats, Sprague-Dawley; D014654:Vascular Patency; D014682:Vena Cava, Inferior / Q000502:physiology / Q000601:surgery* / Q000648:ultrastructure; D014945:Wound Healing