title: Inversion 14q in acute lymphoblastic leukemia of B-lineage.
abstract: Many types of leukemia are associated with specific chromosomal rearrangements. Inversion 14(q11q32) has been reported to be specifically associated with post-thymic T-cell malignancies, including T-chronic lymphocytic leukemia. T-prolymphocytic leukemia, and adult T-cell leukemia/lymphoma. We have previously reported its occurrence in T-cell acute lymphoblastic leukemia. Recently, we encountered a case of acute lymphoblastic leukemia with inv(14)(q11q32), which surprisingly showed a B-cell immunophenotype (CD10+CD19+HLA-DR+Ig mu-).
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: K F
authors.initials: KF
authors.lastname: Wong
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwong
authors.forename: T K
authors.initials: TK
authors.lastname: Wong
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000145:classification; D007446:Chromosome Inversion; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*