title: Induction of normal human eosinophil migration in vitro by substance P.
abstract: To investigate the role of tachykinins in allergic inflammation, the effect of substance P (SP) on normal human eosinophil migration was examined in Boyden chamber type assays. SP stimulated eosinophil migration in vitro with an EC50 of about 1-10 pM and maximal effects were seen at 100 pM. A carboxy-terminal fragment of SP possessed appreciable activity whereas an amino-terminal fragment was inactive. Data represented in this paper and previous studies suggest that eosinophils are attracted by SP and activated to enhanced mediator release and cytotoxic activity.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Innsbruck, Austria.
authors.forename: F J
authors.initials: FJ
authors.lastname: Wiedermann
authors.forename: C M
authors.initials: CM
authors.lastname: Kähler
authors.forename: N
authors.initials: N
authors.lastname: Reinisch
authors.forename: C J
authors.initials: CJ
authors.lastname: Wiedermann
mesh_terms: D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004804:Eosinophils / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D013373:Substance P / Q000494:pharmacology*
chemical_list: D013373:Substance P