title: Cell biology of antigen presentation.
abstract: MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference.
authors.affiliation: The Netherlands Cancer Institute, Amsterdam.
authors.forename: J J
authors.initials: JJ
authors.lastname: Neefjes
authors.forename: F
authors.initials: F
authors.lastname: Momburg
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D000941:Antigens / Q000276:immunology* / Q000378:metabolism; D001692:Biological Transport; D004705:Endocytosis; D010450:Endopeptidases / Q000378:metabolism; D000939:Epitopes / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010446:Peptide Fragments / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding; D001613:beta 2-Microglobulin / Q000378:metabolism
chemical_list: D000941:Antigens; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D010446:Peptide Fragments; D001613:beta 2-Microglobulin; D010450:Endopeptidases