title: Metastatic extramedullary plasmacytoma of the colon and rectum in a dog.
abstract: Stage-3 extramedullary plasmacytoma of the large intestine was diagnosed in an 8-year-old Labrador Retriever. Three primary tumors were located in the colon and rectum, with metastasis to local lymph nodes and the spleen. The disease was associated with a monoclonal serum protein spike identified as IgG. Treatment consisted of surgical excision followed by chemotherapy, using melphalan and prednisone. The dog remained free from clinical signs of disease and adverse effects of the chemotherapy at 9 months. Findings in this dog indicated that extramedullary plasmacytoma may be an aggressive disease, associated with spread to distant sites and monoclonal gammopathy.
authors.affiliation: Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061.
authors.forename: P B
authors.initials: PB
authors.lastname: Trevor
authors.forename: G K
authors.initials: GK
authors.lastname: Saunders
authors.forename: D R
authors.initials: DR
authors.lastname: Waldron
authors.forename: M S
authors.initials: MS
authors.lastname: Leib
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000662:veterinary; D001797:Blood Protein Electrophoresis / Q000662:veterinary; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D008207:Lymphatic Metastasis; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D010954:Plasmacytoma / Q000473:pathology / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D013160:Splenic Neoplasms / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D005719:gamma-Globulins / Q000032:analysis / Q000652:urine
chemical_list: D005719:gamma-Globulins; D008558:Melphalan; D011241:Prednisone