title: [Effects of endothelin-1 on the smooth muscle contractility of human urinary bladder, spermatic cord and prostatic adenoma].
abstract: Effects of endothelin-1 (ET-1) on the smooth muscle contractility of human detrusor, spermatic cord and hypertrophied prostatic adenoma were examined in muscle bath studies. ET-1 increased the contractile forces of all above smooth muscle strips in concentration dependent manner. The contractile force induced by 10(-6) M ET-1 was approximately 30% of that induced by 3 x 10(-5) M carbachol in detrusor muscle strips, approximately 40% of that induced by 10(-4) M norepinephrine in spermatic cord muscle strips and almost equal to that induced by 10(-5) M phenylephrine in prostatic adenoma muscle strips. The contractions induced by ET-1 in those muscle strips were not inhibited by any of tetrodoxine, atropine, phentolamine, propranolol and indomethacine. These results suggest that ET-1 may act as a constrictor on lower urinary tract and genital smooth muscles and especially on prostatic adenoma and that ET-1 may affect those smooth muscles directly not through autonomic receptors or prostaglandins.
authors.affiliation: Department of Urology, Tokyo Medical and Dental University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Kihara
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: T
authors.initials: T
authors.lastname: Kamai
authors.forename: H
authors.initials: H
authors.lastname: Oshima
authors.forename: N
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: S
authors.initials: S
authors.lastname: Kondo
mesh_terms: D000368:Aged; D016232:Endothelins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011467:Prostate / Q000503:physiopathology; D011470:Prostatic Hyperplasia / Q000503:physiopathology*; D013085:Spermatic Cord / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*
chemical_list: D016232:Endothelins