title: FK-506--a novel immunosuppressant.
authors.affiliation: Department of Basic Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065.
authors.forename: W H
authors.initials: WH
authors.lastname: Parsons
authors.forename: N H
authors.initials: NH
authors.lastname: Sigal
authors.forename: M J
authors.initials: MJ
authors.lastname: Wyvratt
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D016572:Cyclosporine / Q000494:pharmacology; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008968:Molecular Conformation; D010749:Phosphoprotein Phosphatases / Q000494:pharmacology; D011090:Polyenes / Q000494:pharmacology; D020123:Sirolimus; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D016559:Tacrolimus / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D022021:Tacrolimus Binding Proteins
chemical_list: D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D011090:Polyenes; D016572:Cyclosporine; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D022021:Tacrolimus Binding Proteins; D020123:Sirolimus; D016559:Tacrolimus