title: Antibody responses against Escherichia coli heat-labile toxin and colonization factor antigens I and II in Argentinian children.
abstract: Serum antibody responses against Escherichia coli heat-labile enterotoxin (LT) and colonization factor antigens (CFAs) I and II were studied in 84 children < 5 years old living in two communities. These villages differed in the quality of their drinking water. Children from both communities developed significantly increased antibody titers against LT and CFA/II but not against CFA/I during 3 months of follow-up. The magnitude of the anti-LT response was significantly higher in children from Zaiman than in those from Las Dolores. Antibody titers rose to maximum levels during the second year of age and reached relatively constant levels in children aged 2-5 years, probably due to repeated exposure to enterotoxigenic E. coli strains. Antibody levels of 30 children were followed for 2 years; increases in anti-LT and anti-CFA titers varied in the different age groups.
authors.affiliation: Instituto Nacional de Microbiologia Carlos G. Malbran, Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Rivas
authors.forename: N
authors.initials: N
authors.lastname: Binsztein
authors.forename: G
authors.initials: G
authors.lastname: Basanta
authors.forename: M
authors.initials: M
authors.lastname: Vergara
authors.forename: M
authors.initials: M
authors.lastname: Quiroga
authors.forename: R
authors.initials: R
authors.lastname: Cinto
authors.forename: A M
authors.initials: AM
authors.lastname: Svennerholm
mesh_terms: D000367:Age Factors; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D001118:Argentina; D001426:Bacterial Proteins / Q000276:immunology*; D001427:Bacterial Toxins / Q000276:immunology*; D002675:Child, Preschool; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology; D004768:Enterotoxins / Q000276:immunology*; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology; D029968:Escherichia coli Proteins; D005243:Feces / Q000382:microbiology; D036781:Fimbriae Proteins; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011446:Prospective Studies; D014871:Water Microbiology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C022924:colonization factor antigens; D036781:Fimbriae Proteins; C027538:heat-labile enterotoxin, E coli