title: Increased incidence of oviduct pathology in the guinea pig after repeat vaginal inoculation with the chlamydial agent of guinea pig inclusion conjunctivitis.
abstract: OBJECTIVE
  Although it has been hypothesized that repeated infections with Chlamydia trachomatis result in an increased potential for the development of infertility, it is not know whether repeated chlamydial infection by the vaginal route will result in an increased incidence of upper tract pathology or enhanced pathology.
  
  
  OBJECTIVE
  To determine whether guinea pigs given two infections with the chlamydial agent of guinea pig inclusion conjunctivitis would experience an increased incidence of pathologic changes compared with animals having only a single infection.
  
  
  METHODS
  Guinea pigs previously infected with guinea pig inclusion conjunctivitis were challenged with a fresh intravaginal inoculum 73-77 days after the primary infection. Oviducts were examined either nine or 30 to 37 days after the challenge infection for pathologic changes and compared with control unchallenged animals 75 to 85 days after a primary infection.
  
  
  RESULTS
  A significant increase in the number of animals with oviducts demonstrating marked tubal dilatation was observed in the challenged animals 30 to 37 days after the challenge infection. There was no association of increased antibody titer and chlamydial Hsp60 with the presence of tubal dilatation.
  
  
  CONCLUSIONS
  These data strongly indicate that repeated infection via the natural vaginal route does increase the risk of tubal damage.
authors.affiliation: Department of Microbiolgy and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205.
authors.forename: R G
authors.initials: RG
authors.lastname: Rank
authors.forename: M M
authors.initials: MM
authors.lastname: Sanders
authors.forename: D L
authors.initials: DL
authors.lastname: Patton
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000097:blood; D018834:Chaperonin 60 / Q000097:blood; D002690:Chlamydia Infections / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000276:immunology; D003235:Conjunctivitis, Inclusion / Q000382:microbiology*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D015994:Incidence; D012008:Recurrence; D012488:Salpingitis / Q000097:blood / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D014621:Vagina / Q000382:microbiology*
chemical_list: D001426:Bacterial Proteins; D018834:Chaperonin 60