Idiotype-dependent repertoire generation in the network system.
The diversification of the receptors of B and T lymphocytes is determined by stepwise gene rearrangement of the V genes and the D-J segment. However, this repertoire is not yet selected within the host environment and thus is referred to as the potential repertoire. The repertoire of the peripheral mature B and T-lymphocytes is distorted and selected from the potential repertoire by various auto- and foreign antigens in the host environment and is referred to as the available repertoire. It is well documented that the peripheral T-lymphocyte repertoire is first selected in the thymus to delete or inactivate self-reactive clones. Moreover, extensive studies done during the last decade suggest that the B- and T-lymphocyte repertoires are significantly influenced by the host immunoglobulin idiotype repertoire. In this review, the role of immunoglobulin idiotypes in the selection of the B- and T-lymphocyte repertoires is discussed.
Yamamoto
H
H
Department of Immunology, National Center of Neurology and Psychiatry, Tokyo, Japan.
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens; D005803:Genes, Immunoglobulin; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000502:physiology*; D007136:Immunoglobulins / Q000502:physiology; D007519:Isoantigens / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D018956:CD5 Antigens; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins; D007519:Isoantigens