title: [Basic theory of nervous system disorders: generative, determinant and systemic mechanisms].
abstract: The paper deals with the virtually unknown and little studied aspect of the pathogenesis of nervous disorders, which consists in emergence of new pathological integrations in the central nervous system (CNS). The formation and activity of these integrations are realized by endogenous mechanisms intrinsic to the damaged nervous system. The pathological integration of hyperactive neurons as their aggregate is a generator of pathologically enhanced excitation (GPEE). GPEE is capable of producing intense and uncontrolled impulse flow and developing in certain conditions self-sustained and even increased activity. The CNS region where GPEE is formed, becomes hyperactive, alters the other, linked with it, CNS structures and induces the formation of systemic pathologic integration in the form of a new pathodynamic organization, i.e. pathologic system (PS). This system-forming CNS region plays a role of a key, determinant part of PS. The main biological feature, which makes PS different from physiological systems, it is inadaptive or direct pathogenic significance for the organism. The neuropathologic syndrome is a clinical manifestation of PS activity. Each neuropathologic syndrome has an appropriate PS, and its specificity and content depend on which CNS structures constitute PS. Due to plasticity processes, the positive links between the PS part become consolidated with time and as a result the PS resistance to endogenous sanogenetic mechanisms and curative therapeutic treatment increases. In creating GPEE in a certain, pathogenetically important CNS region, one can reproduce the corresponding neuropathologic syndrome in modelling experiments. The basic principle in the treatment of nervous disorders consists in elimination of their pathologic systems.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: G N
authors.initials: GN
authors.lastname: Kryzhanovskiĭ
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008954:Models, Biological; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D013238:Stereotaxic Techniques
chemical_list: D000927:Anticonvulsants