title: Safety of rapid-rate transcranial magnetic stimulation in normal volunteers.
abstract: In 9 normal volunteers, we studied the safety of rapid-rate transcranial magnetic stimulation (rTMS) applied to different scalp positions at various frequencies and intensities. Pure tone threshold audiometry showed temporary threshold shifts in 3 subjects. In the subject stimulated at the highest intensity, rTMS induced a focal, secondarily generalized seizure despite the absence of definite risk factors for seizures. Rapid-rate TMS did not result in any important changes in the neurological examination findings, cognitive performance, electroencephalogram, electrocardiogram, and hormone levels (prolactin, adrenocorticotropic hormone, thyroid-stimulating hormone, luteinizing hormone, and follicle-stimulating hormone). In 10 additional subjects, the electromyographic activity in several contralateral muscles showed that trains of rTMS applied to the motor cortex induced a spread of cortical excitability. The spread of excitability depended on the intensity and frequency of the stimuli and probably constituted an early epileptogenic effect of rTMS. Guidelines for preventing the undesirable side effects of rTMS are offered.
authors.affiliation: Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
authors.forename: A
authors.initials: A
authors.lastname: Pascual-Leone
authors.forename: C M
authors.initials: CM
authors.lastname: Houser
authors.forename: K
authors.initials: K
authors.lastname: Reese
authors.forename: L I
authors.initials: LI
authors.lastname: Shotland
authors.forename: J
authors.initials: J
authors.lastname: Grafman
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: J
authors.initials: J
authors.lastname: Valls-Solé
authors.forename: J P
authors.initials: JP
authors.lastname: Brasil-Neto
authors.forename: E M
authors.initials: EM
authors.lastname: Wassermann
authors.forename: L G
authors.initials: LG
authors.lastname: Cohen
mesh_terms: D000328:Adult; D001299:Audiometry; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009132:Muscles / Q000502:physiology; D009479:Neuropeptides / Q000097:blood; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012449:Safety; D050781:Transcranial Magnetic Stimulation / Q000009:adverse effects*
chemical_list: D006065:Gonadotropins, Pituitary; D009479:Neuropeptides