A second case of trisomy 8 in Philadelphia chromosome (Ph)-negative cells during the course of Ph-positive chronic myelocytic leukemia.
A Ph-positive CML patient who had received a peripheral blood stem cell autograft in chronic phase demonstrated a transient regression of the Ph-positive clone with the concurrent appearance of another clone with trisomy 8. This latter clone disappeared when the patient received alpha-interferon.
Bilhou-Nabera
C
C
Marit
G
G
Devianne
I
I
Viard
F
F
Salzes
S
S
Montastruc
M
M
Renoux
M
M
Broustet
A
A
Reiffers
J
J
Bernard
P
P
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D016465:Bone Marrow Purging / Q000009:adverse effects; D002898:Chromosomes, Human, Pair 8; D002999:Clone Cells / Q000648:ultrastructure; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology*; D010677:Philadelphia Chromosome; D014314:Trisomy