Lower serum high-density lipoprotein-cholesterol concentration in patients undergoing maintenance hemodialysis with acetate than with bicarbonate.
The authors studied the effect of dialysate buffer composition on the serum lipid values in male patients undergoing maintenance hemodialysis. Twenty patients on acetate and 21 patients on bicarbonate hemodialysis were investigated. The serum concentrations of high-density lipoprotein (HDL)-, HDL2- and HDL3-cholesterol were significantly lower in patients on acetate than in those on bicarbonate dialysis. The results of this study suggest possible adverse effects of acetate hemodialysis on serum HDL-cholesterol compared with bicarbonate hemodialysis. Other possibly contributory factors such as age and time on dialysis could be excluded. However, a possible role of differences in drug therapy between acetate- and bicarbonate-treated dialysis patients could not be entirely excluded.
Jung
K
K
Department of Urology, University Hospital Charité, Humboldt University Berlin, Germany.
Scheifler
A
A
Schulze
B D
BD
Scholz
M
M
D000085:Acetates / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D001639:Bicarbonates / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood
D000085:Acetates; D001639:Bicarbonates; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol