Assignment of human beta-galactosidase-A gene to 3p21.33 by fluorescence in situ hybridization.
GM1 gangliosidosis and Morquio syndrome type B (MPS IVB) are inherited lyosomal storage disorders associated with deficiency of beta-galactosidase-A (beta GALA) activity. A recombinant plasmid containing a biotinylated cDNA (2.4-kb insert) encoding human beta GALA was used to localize the enzyme locus by fluorescence in situ hybridization (FISH). The human beta GALA gene was assigned to 3p21.33 by FISH.
Takano
T
T
Department of Hygiene, Teikyo University School of Medicine, Tokyo, Japan.
Yamanouchi
Y
Y
D006690:Bisbenzimidazole; D002871:Chromosome Banding; D002893:Chromosomes, Human, Pair 3 / Q000201:enzymology*; D004247:DNA / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D010957:Plasmids / Q000235:genetics; D001616:beta-Galactosidase / Q000235:genetics* / Q000378:metabolism
D004247:DNA; D001616:beta-Galactosidase; D006690:Bisbenzimidazole