title: Alterations in the ontogeny of rat pup ultrasonic vocalization produced by prenatal exposure to nitrogen dioxide.
abstract: Wistar female rats were exposed to low concentrations of nitrogen dioxide, NO2 (1.5 and 3 ppm) from day 0 to day 20 of pregnancy. The results show that prenatal exposure to this oxidant gas produced significant changes in the duration pattern of ultrasonic vocalizations emitted by male pups removed from their nest. In particular, a significant decrease in the length of ultrasonic calls was found in both 10- and 15-day-old rats exposed to NO2 (3 ppm) during gestation. These alterations were found at dose levels which did not significantly affect reproduction parameters, body weight gain and motor activity development. These findings suggest that gestational exposure to NO2, at concentrations below those associated with overt signs of toxicity, induces in rat offspring subtle behavioral changes characterized by altered ontogeny of ultrasonic emission.
authors.affiliation: Institute of Pharmacology, University of Bari, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Di Giovanni
authors.forename: R
authors.initials: R
authors.lastname: Cagiano
authors.forename: M R
authors.initials: MR
authors.lastname: Carratù
authors.forename: M A
authors.initials: MA
authors.lastname: De Salvia
authors.forename: A
authors.initials: A
authors.lastname: Giustino
authors.forename: V
authors.initials: V
authors.lastname: Cuomo
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D014465:Ultrasonics; D014828:Vocalization, Animal / Q000187:drug effects*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D009585:Nitrogen Dioxide