Inversion 14q in acute lymphoblastic leukemia of B-lineage.
Many types of leukemia are associated with specific chromosomal rearrangements. Inversion 14(q11q32) has been reported to be specifically associated with post-thymic T-cell malignancies, including T-chronic lymphocytic leukemia. T-prolymphocytic leukemia, and adult T-cell leukemia/lymphoma. We have previously reported its occurrence in T-cell acute lymphoblastic leukemia. Recently, we encountered a case of acute lymphoblastic leukemia with inv(14)(q11q32), which surprisingly showed a B-cell immunophenotype (CD10+CD19+HLA-DR+Ig mu-).
Wong
K F
KF
Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Kwong
Y L
YL
Wong
T K
TK
D000328:Adult; D001402:B-Lymphocytes / Q000145:classification; D007446:Chromosome Inversion; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*