title: A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL gene.
abstract: Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed-lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene.
authors.affiliation: Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263.
authors.forename: S N
authors.initials: SN
authors.lastname: Jani Sait
authors.forename: S C
authors.initials: SC
authors.lastname: Raimondi
authors.forename: A T
authors.initials: AT
authors.lastname: Look
authors.forename: H
authors.initials: H
authors.lastname: Gill
authors.forename: M
authors.initials: M
authors.lastname: Thirman
authors.forename: M O
authors.initials: MO
authors.lastname: Diaz
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
mesh_terms: D015139:Blotting, Southern; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D008297:Male; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D015183:Restriction Mapping; D014178:Translocation, Genetic