title: Expression of the hepatocyte growth factor receptor in the regenerating rat liver.
abstract: The c-met oncogene product is a cell-surface receptor, which ligand is believed to be the hepatocyte growth factor. We studied the expression of c-met oncogene in the regenerating rat liver after either partial hepatectomy or CCl4-induced liver injury. Northern blot analysis showed that after partial hepatectomy the transcripts of c-met decreased at 8 h, reached the minimum at 36 h, and returned to the steady level on the seventh day. In contrast with the hepatectomized liver, the transcripts of c-met increased after CCl4 treatment. These observations suggest that c-met transcription may be regulated differently depending on regeneration signals.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: N
authors.initials: N
authors.lastname: Enomoto
authors.forename: N
authors.initials: N
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Kurosaki
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: F
authors.initials: F
authors.lastname: Marumo
authors.forename: C
authors.initials: C
authors.lastname: Sato
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002251:Carbon Tetrachloride / Q000008:administration & dosage; D006498:Hepatectomy; D008115:Liver Regeneration / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D019859:Proto-Oncogene Proteins c-met; D012313:RNA / Q000302:isolation & purification; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D011518:Proto-Oncogene Proteins; D012313:RNA; D002251:Carbon Tetrachloride; D019859:Proto-Oncogene Proteins c-met