title: Acute and long-term ventricular stimulation thresholds with a new, iridium oxide-coated electrode.
abstract: Efforts have been made to design electrodes that significantly reduce not only the acute and chronic stimulation thresholds, but also attenuate the early peaking phenomenon and polarization. At two voltage levels (2.7 V and 5.4 V, respectively), we evaluated the right ventricular stimulation thresholds obtained with a new, iridium oxide-coated electrode in ten patients who received a VVI pacemaker. Measurements were made at implant and at multiple intervals for 1 year. Pulse width stimulation thresholds at implant were as follow: 0.04 +/- 0.008 msec at 2.7 V, 0.03 +/- 0.004 msec at 5.4 V; values at 2 weeks were 0.14 +/- 0.06 msec at 2.7 V, 0.07 +/- 0.025 msec at 5.4 V; values at 3 months were 0.09 +/- 0.03 msec at 2.7 V, 0.05 +/- 0.01 msec at 5.4 V; values at 1 year were 0.08 +/- 0.02 msec at 2.7 V, 0.04 +/- 0.01 msec at 5.4 V. The maximal increase of 0.11 +/- 0.05 msec occurred at 2.7 V, 2 weeks after implant. Our results indicate that this new electrode provides low acute and long-term stimulation thresholds, as well as an attenuated early peaking phenomenon, being able to stimulate safely at 2.7 V even early after implant.
authors.affiliation: Division of Cardiology, CHUV, Lausanne, Switzerland.
authors.forename: A G
authors.initials: AG
authors.lastname: Del Bufalo
authors.forename: J
authors.initials: J
authors.lastname: Schlaepfer
authors.forename: M
authors.initials: M
authors.lastname: Fromer
authors.forename: L
authors.initials: L
authors.lastname: Kappenberger
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000379:methods; D004567:Electrodes, Implanted; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000628:therapy; D006801:Humans; D007495:Iridium; D008297:Male; D010138:Pacemaker, Artificial; D012804:Sick Sinus Syndrome / Q000628:therapy; D013997:Time Factors
chemical_list: C044458:iridium oxide; D007495:Iridium