Two distinct types of AMPA responses in cultured rat hippocampal neurons.
We previously found two distinct types of responses to kainate in cultured rat hippocampal neurons. The type I response is characterized by very little increase in Ca2+ permeability with an outward rectification in the current-voltage (I-V) relation of the kainate response. In contrast, the type II kainate response is characterized by prominent Ca2+ permeability and an inward rectification. These two types of responses were mimicked by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA). Furthermore, AMPA cross-desensitized both types of kainate responses. These results indicate that two functionally different types of AMPA/kainate receptors are expressed in hippocampal neurons.
Ozawa
S
S
Department of Physiology, School of Medicine, Gunma University, Japan.
Iino
M
M
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D007051:Ibotenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D015640:Ion Channel Gating / Q000187:drug effects*; D007608:Kainic Acid / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011760:Pyrrolidinones / Q000494:pharmacology; D051381:Rats; D018091:Receptors, AMPA; D017470:Receptors, Glutamate / Q000187:drug effects* / Q000502:physiology; D018092:Kainic Acid Receptors; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D002118:Calcium; D015220:Calcium Channels; D007051:Ibotenic Acid; D007608:Kainic Acid; D011760:Pyrrolidinones; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D018092:Kainic Acid Receptors; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; C036466:aniracetam