High dose Nutrizym 22 in cystic fibrosis.
New high dose pancreatic enzyme preparations could be potentially helpful to cystic fibrosis (CF) patients. The purpose of this study was to compare the efficacy of the new high dose pancreatic enzyme preparation, Nutrizym 22 with the standard preparation Nutrizym GR. Twenty-five CF children (aged 7-16 years) entered the study and 22 completed it; 3 did not, due to non-compliance. All were taking Nutrizym GR for at least 2 weeks before entering the study. A randomised double blind, crossover method using standard Nutrizym GR or double strength Nutrizym 22 capsules was carried out over two consecutive 14-day periods. Crossover analyses of variance showed no statistically significant differences in actual weight gain, appetite, abdominal pain, stool consistency or faecal fat during the prestudy and study periods. It is concluded that half the capsule numbers of the high strength preparation are just as effective as the standard capsule dosage.
Shah
A
A
Cystic Fibrosis Unit, Hospital for Sick Children, London, United Kingdom.
Dinwiddie
R
R
Madge
S
S
Prescott
P
P
Hudson
G
G
D000293:Adolescent; D000681:Amylases / Q000008:administration & dosage* / Q000627:therapeutic use; D000704:Analysis of Variance; D001963:Bromelains / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D003550:Cystic Fibrosis / Q000188:drug therapy*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008049:Lipase / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D010179:Pancreas / Q000201:enzymology; D014357:Trypsin / Q000008:administration & dosage* / Q000627:therapeutic use
D004338:Drug Combinations; C002762:Nutrizym; D001963:Bromelains; D008049:Lipase; D000681:Amylases; D014357:Trypsin