Protective effect of lactoferrin on caerulein-induced acute pancreatitis in rats.
In rats we studied the effects of lactoferrin on experimental acute pancreatitis caused by a single subcutaneous injection of 100 micrograms/kg body weight of caerulein. Lactoferrin isolated from human milk was given intraperitoneally to rats immediately after the injection of caerulein. The injection of 100 mg/kg body weight of lactoferrin significantly reduced the elevation of the serum amylase level and pancreatic wet weight; histological alterations of the pancreas were markedly suppressed. These results suggested that lactoferrin had a protective effect on the biochemical and histological alterations in this model.
Koike
D
D
Second Department of Internal Medicine, Asahikawa Medical College, Japan.
Makino
I
I
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D002108:Ceruletide; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007501:Iron / Q000097:blood; D007781:Lactoferrin / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008895:Milk, Human / Q000737:chemistry; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
D002108:Ceruletide; D007501:Iron; D000681:Amylases; D007781:Lactoferrin