SEB induced anergy: modulation of immune response to T cell determinants of myoglobin and myelin basic protein.
Superantigens have the ability to stimulate a subset of T cells based upon their expressed TCR beta-chain. It has been demonstrated that the administration of staphylococcal enterotoxin B (SEB) in mice leads to unresponsiveness in V beta 8+ T cells in vivo which are the same T cells that could be stimulated in vitro by this enterotoxin. We present here data on the effect of SEB administration in DBA/2 and (PL/J x SJL)F1 mice on their T cell response to two different T cell determinants, the responses against which are dominated by the use of V beta 8+ T cells. Treatment of mice with SEB not only diminished their primary T cell proliferative response to these determinants, but also was able to effectively reduce the memory T cell response. SEB treatment, however, showed only a modest effect in preventing Ac 1-11-induced experimental autoimmune encephalomyelitis in H-2u mice.
Gaur
A
A
Department of Medicine, Stanford University School of Medicine, CA 94305.
Fathman
C G
CG
Steinman
L
L
Brocke
S
S
D000595:Amino Acid Sequence; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D004768:Enterotoxins / Q000494:pharmacology*; D000939:Epitopes / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007156:Immunologic Memory / Q000187:drug effects; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000276:immunology*; D009211:Myoglobin / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D004768:Enterotoxins; D000939:Epitopes; D004676:Myelin Basic Protein; D009211:Myoglobin; D010446:Peptide Fragments; C031818:enterotoxin B, staphylococcal