title: Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate.
authors.affiliation: Upjohn Laboratories, Kalamazoo, Michigan 49001.
authors.forename: D L
authors.initials: DL
authors.lastname: Romero
authors.forename: R A
authors.initials: RA
authors.lastname: Morge
authors.forename: M J
authors.initials: MJ
authors.lastname: Genin
authors.forename: C
authors.initials: C
authors.lastname: Biles
authors.forename: M
authors.initials: M
authors.lastname: Busso
authors.forename: L
authors.initials: L
authors.lastname: Resnick
authors.forename: I W
authors.initials: IW
authors.lastname: Althaus
authors.forename: F
authors.initials: F
authors.lastname: Reusser
authors.forename: R C
authors.initials: RC
authors.lastname: Thomas
authors.forename: W G
authors.initials: WG
authors.lastname: Tarpley
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D020008:Delavirdine; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D010879:Piperazines; D018894:Reverse Transcriptase Inhibitors; D020008:Delavirdine