[Immunological treatment of spontaneous repeated abortions. The value of transfusing the partner's leukocytes in the third week of gestation].
Twenty-two nulli- all primipara who had had previous repeated spontaneous abortions and who did not have anti-HLA antibodies for the partner, received immunological treatment consisting of a single transfusion of the partner's lymphocytes in the third week of pregnancy, and giving natural progesterone supplements after the kinetic of Beta-HCG in the plasma had been assessed. The number of pregnancies which went to terme (94% success) was significantly better than those obtained in our first protocol which was to give one to three transfusions of the partner's lymphocytes before the pregnancy started (58% success rare after 24 treatments). Apart from obtaining much better results the second protocol made it possible to avoid giving a significant number of useless transfusions (22% of pre-conceptual transfusions were not followed by a pregnancy at all).
Sagot
P
P
Département de Gynécologie-Obstétrique et Biologie de la Reproduction, CHRU, Nantes.
Bignon
J D
JD
Cesbron
A
A
Laurent
F X
FX
Adjou
C
C
Muller
J Y
JY
D000026:Abortion, Habitual / Q000097:blood / Q000276:immunology* / Q000628:therapy*; D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D017708:Leukocyte Transfusion / Q000379:methods*; D010446:Peptide Fragments / Q000097:blood; D016742:Preconception Care / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000008:administration & dosage / Q000627:therapeutic use; D012747:Sexual Partners
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006680:HLA Antigens; D010446:Peptide Fragments; D011374:Progesterone