Ozone, NO, and NO2: oxidant air pollutants and more.
This article reviews the acute and chronic toxicity of the three oxidant air pollutants ozone, nitric oxide (NO), and nitrogen dioxide (NO2). The toxicity of binary mixtures of NO2 with other inhaled agents is also discussed. Newer studies are emphasized, especially those published in the last 5 years or still in press. Very recent data from our laboratory that suggest a new cellular mechanism of importance in lung injury in animals exposed to mixtures of ozone and NO2 that may have general relevance with regard to the effects of oxidant air pollutants on the lung are also presented.
Last
J A
JA
Department of Internal Medicine (Pulmonary Division), California Regional Primate Research Center, University of California, Davis 95616-8542.
Sun
W M
WM
Witschi
H
H
D000393:Air Pollutants; D000818:Animals; D004357:Drug Synergism; D006801:Humans; D008168:Lung / Q000187:drug effects; D009569:Nitric Oxide / Q000494:pharmacology; D009585:Nitrogen Dioxide / Q000494:pharmacology; D016877:Oxidants; D010126:Ozone / Q000494:pharmacology
D000393:Air Pollutants; D016877:Oxidants; D009569:Nitric Oxide; D010126:Ozone; D009585:Nitrogen Dioxide