title: Distal ileum resection totally suppresses the late pancreatic postprandial hypersecretion in conscious dogs.
abstract: Exocrine pancreatic secretion and serum levels of secretin, vasoactive intestinal peptide (VIP) and gastrin within postprandial 12 hours have been studied in dogs that have undergone a partial ileum resection (last 25 cm) 4 weeks before. In these conditions the following effects were observed: 1) the flow of pancreatic juice secreted after the food intake (1-4h period) was strictly similar to the flow described in intact dogs which did not suffer that surgical manipulation but it came back to its basal value more rapidly; 2) there were no effects regarding the postprandial hormonal pattern; 3) the late pancreatic hypersecretion period that is usually observed in intact dogs within the postprandial 8-12 h period, completely disappeared. These results allow to conclude that the mechanisms inducing the late hypersecretion process that usually takes place within the postprandial 8-12 h in dogs are generated in the distal ileum.
authors.affiliation: Departamento de Fisiologia, Universidad de Granada, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Huertas
authors.forename: E
authors.initials: E
authors.lastname: Martinez-Victoria
authors.forename: M C
authors.initials: MC
authors.lastname: Ballesta
authors.forename: F J
authors.initials: FJ
authors.lastname: Mataix
authors.forename: M
authors.initials: M
authors.lastname: Mañas
mesh_terms: D000818:Animals; D004285:Dogs; D004386:Duodenum; D004435:Eating / Q000502:physiology*; D005755:Gastrins / Q000097:blood; D005766:Gastrointestinal Contents; D006863:Hydrogen-Ion Concentration; D007081:Ileostomy / Q000009:adverse effects*; D010179:Pancreas / Q000378:metabolism*; D012633:Secretin / Q000097:blood; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000097:blood
chemical_list: D005755:Gastrins; D012633:Secretin; D014660:Vasoactive Intestinal Peptide