Methyl angolensate: the antiulcer agent of the stem bark of Entandrophragma angolense.
Methyl angolensate (1), the major compound isolated from the methanol extract of the stem bark of Entandrophragma angolense produced a dose-related inhibition of gastric ulceration, 40 mg/kg body weight (B.W.) being more effective than 40 mg/kg B.W. of propranolol. The highest dose used (80 mg/kg B.W.) completely inhibited gastric ulceration and significantly reduced gastric acidity (P < 0.05). Furthermore, 1 (40 mg/kg B.W.) significantly reduced gastric acid secretion induced by histamine (1.0 mg/kg B.W.) and carbachol (1.0 mg/kg B.W.). These results suggest that 1 produces its antiulcer activity by inhibition of gastric acid secretion.
Njar
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Adesanwo
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Raji
Y
Y
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014315:Triterpenes / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D014315:Triterpenes; C092741:methyl angolensate