title: Bio-active compounds from Psychotria camponutans.
abstract: A new benzoquinone (1-hydroxybenzoisochromanquinone) and benz [g]isoquinoline-5, 10-dione have been isolated from the woody parts of Psychotria camponutans, as a result of bioactivity-guided fractionation. The compounds were characterized by UV, IR, EI-mass, 1H-, and 13C-NMR, and HETCOR NMR spectroscopy. Both compounds, together with acetylbenzoisochromanquinone, showed in vitro strong activity against brine shrimp, KB cells, and chloroquine-resistant P. falciparum.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, University of London, U.K.
authors.forename: P N
authors.initials: PN
authors.lastname: Solis
authors.forename: C
authors.initials: C
authors.lastname: Lang'at
authors.forename: M P
authors.initials: MP
authors.lastname: Gupta
authors.forename: G C
authors.initials: GC
authors.lastname: Kirby
authors.forename: D C
authors.initials: DC
authors.lastname: Warhusrst
authors.forename: J D
authors.initials: JD
authors.lastname: Phillipson
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet
chemical_list: D010936:Plant Extracts