Cytotoxic constituents of Bursera permollis.
Four cytotoxic lignans were isolated from the stem bark of Bursera permollis (Burseraceae), namely, deoxypodophyllotoxin (1), beta-peltatin methyl ether (2), picro-beta-peltatin methyl ether (3), and dehydro-beta-peltatin methyl ether (4). Also isolated was the inactive lignan, nemerosin (5). Compounds 1 and 2 were potently cytotoxic when evaluated against a panel of human cancer cell lines.
Wickramaratne
D B
DB
Mar
W
W
Chai
H
H
Castillo
J J
JJ
Farnsworth
N R
NR
Soejarto
D D
DD
Cordell
G A
GA
Pezzuto
J M
JM
Kinghorn
A D
AD
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D010944:Plants / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic