Complete testicular feminization with normal gonadotropin and high androgen secretion: a case report.
A patient with a complete form of testicular feminization with normal gonadotropin and high testosterone levels is described here. These findings are in contrast to previous reports that have shown high circulating luteinizing hormone (LH) levels in adults affected by this syndrome. Testicular histology revealed tubular atrophy and hyperplastic Leydig cells which are in accordance with the high testosterone levels and the difficulty in visualization of the testes. Because of the increased risk of gonadal malignancy, a laparoscopic gonadectomy was performed.
Doldi
N
N
Department of Obstetrics and Gynecology, University of Milan, San Raffaele Scientific Institute, Italy.
Busacca
M
M
Bombelli
F
F
Sironi
L
L
Ferrari
A
A
D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D000728:Androgens / Q000097:blood*; D004967:Estrogens / Q000097:blood; D005260:Female; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D007985:Leydig Cells / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood
D000728:Androgens; D004967:Estrogens; D006062:Gonadotropins; D013739:Testosterone; D007986:Luteinizing Hormone