[The endotoxin receptor CD14].
The knowledge about molecular mechanisms of endotoxin (LPS) recognition by cellular receptor CD14 and its consequences as well as the relationship between soluble and membrane-bound receptor is reviewed. The binding of endotoxins to membrane-bound CD14 is mediated by special so-called LPS-binding serum proteins. The mechanism of signal transduction is not yet known. After activation by LPS, monocytes produce free oxygen radicals, IL-1, IL-6, TNF alpha and other mediators. CD14 is present in normal serum as soluble receptor which can neutralize endotoxins in respect to their monocyte activating capacity.
Schütt
C
C
Institut für Immunologie und Transfusionsmedizin, Universität Greifswald.
Schumann
R
R
D015703:Antigens, CD / Q000502:physiology*; D015214:Antigens, Differentiation, Myelomonocytic / Q000502:physiology*; D001424:Bacterial Infections / Q000503:physiopathology; D004731:Endotoxins / Q000378:metabolism*; D005796:Genes; D006090:Gram-Negative Bacteria / Q000472:pathogenicity; D006801:Humans; D018950:Lipopolysaccharide Receptors; D009000:Monocytes / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*; D012772:Shock, Septic / Q000503:physiopathology; D015398:Signal Transduction
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D004731:Endotoxins; D018950:Lipopolysaccharide Receptors; D011956:Receptors, Cell Surface