title: [Therapeutic efficacy of lanoconazole ointment in guinea pig model of tinea corporis, a comparative study with ointment and cream preparations].
abstract: The therapeutic efficacy of ointment and cream preparations of lanoconazole in a guinea pig model of tinea corporis was compared on the basis of degrees of improvement in local symptoms and negative culture rates. When infected animals were treated once daily with 0.25%, 0.5% and 1% lanoconazole ointments, significant improvement of the symptoms and mycological curative effects were observed as compared to those of non-treated control and vehicle-treated control groups of animals. Particularly, in animals treated with 0.5 or 1% lanoconazole ointment, no fungus was recovered from any infected loci. Comparing these results with those obtained with comparable concentrations of lanoconazole cream, no significant difference was found. These studies, therefore, suggested that ointment and cream preparations of lanoconazole on topical application would show basically equivalent therapeutic efficacy in the tinea corporis model.
authors.affiliation: Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd.
authors.forename: Y
authors.initials: Y
authors.lastname: Niwano
authors.forename: T
authors.initials: T
authors.lastname: Tabuchi
authors.forename: K
authors.initials: K
authors.lastname: Kanai
authors.forename: H
authors.initials: H
authors.lastname: Hamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006571:Heterocyclic Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D007093:Imidazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D009824:Ointments; D014005:Tinea / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D007093:Imidazoles; D009824:Ointments; C072774:latoconazole