In vivo evaluation of reuterin and its combinations with suramin, melarsoprol, DL-alpha-difluoromethylornithine and bleomycin in mice infected with Trypanosoma brucei brucei.
1. Trypanosoma brucei brucei-infected mouse models treated with a new antibiotic, reuterin, showed reduction of the levels of parasitemia and prolonged survival of the mice. 2. Cures of the parasitemia were observed in groups of mice treated with combinations of reuterin and suramin or melarsoprol. 3. Reuterin administered in combination with bleomycin or DL-alpha-difluoromethylornithine showed temporary remission of the parasitemia in groups of mice.
Yunmbam
M K
MK
Department of Zoology, North Carolina State University, Raleigh 27695-7617.
Roberts
J F
JF
D000447:Aldehydes; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D004359:Drug Therapy, Combination; D000518:Eflornithine / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D005985:Glyceraldehyde / Q000031:analogs & derivatives; D007928:Lethal Dose 50; D008549:Melarsoprol / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D011407:Propane; D013498:Suramin / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000469:parasitology
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D001761:Bleomycin; C047158:3-hydroxypropionaldehyde; D005985:Glyceraldehyde; D013498:Suramin; D011407:Propane; D008549:Melarsoprol; D000518:Eflornithine