title: Effects of various absorption promoters on pulmonary absorption of drugs with different molecular weights.
abstract: The effects of various absorption promoters on the pulmonary absorption of drugs with different molecular weights were examined in rats. Phenol red and fluorescein isothiocyanate-labeled dextrans (FDs) with various molecular weights were used as model drugs and the absorption promoters used in this study were sodium glycocholate, sodium salicylate, ethylenediaminetetraacetic acid disodium salt (Na2-EDTA) and sodium caprate, all at a concentration of 1%. Of these absorption promoters, sodium glycocholate and sodium caprate appeared to be more effective for enhancing the pulmonary absorption of these drugs than sodium salicylate and Na2-EDTA. Furthermore, it was indicated that there is the optimal molecular weight to which each absorption promoter gives the largest enhancing effect on the pulmonary absorption of drugs.
authors.affiliation: Department of Basic Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: A
authors.initials: A
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Hashida
authors.forename: H
authors.initials: H
authors.lastname: Sezaki
mesh_terms: D000042:Absorption / Q000187:drug effects; D000818:Animals; D003911:Dextrans / Q000493:pharmacokinetics; D005079:Excipients / Q000494:pharmacology*; D016650:Fluorescein-5-isothiocyanate / Q000493:pharmacokinetics / Q000031:analogs & derivatives; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D010637:Phenolsulfonphthalein / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet; D013268:Stimulation, Chemical
chemical_list: D003911:Dextrans; D005079:Excipients; C015219:fluorescein isothiocyanate dextran; D016650:Fluorescein-5-isothiocyanate; D010637:Phenolsulfonphthalein