title: The vascular E-selectin binds to the leukocyte integrins CD11/CD18.
abstract: Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Lex carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.
authors.affiliation: Department of Biochemistry, University of Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Kotovuori
authors.forename: E
authors.initials: E
authors.lastname: Tontti
authors.forename: R
authors.initials: R
authors.lastname: Pigott
authors.forename: M
authors.initials: M
authors.lastname: Shepherd
authors.forename: M
authors.initials: M
authors.lastname: Kiso
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
authors.forename: R
authors.initials: R
authors.lastname: Renkonen
authors.forename: P
authors.initials: P
authors.lastname: Nortamo
authors.forename: D C
authors.initials: DC
authors.lastname: Altieri
authors.forename: C G
authors.initials: CG
authors.lastname: Gahmberg
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D018845:CD11 Antigens; D018821:CD18 Antigens; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D019040:E-Selectin; D000939:Epitopes / Q000378:metabolism; D016023:Integrins / Q000378:metabolism*; D007962:Leukocytes / Q000737:chemistry* / Q000276:immunology; D007983:Lewis Blood Group Antigens / Q000276:immunology; D011994:Recombinant Proteins / Q000378:metabolism; D014162:Transfection
chemical_list: D015703:Antigens, CD; D018845:CD11 Antigens; D018821:CD18 Antigens; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D000939:Epitopes; D016023:Integrins; D007983:Lewis Blood Group Antigens; D011994:Recombinant Proteins