Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate.
Romero
D L
DL
Upjohn Laboratories, Kalamazoo, Michigan 49001.
Morge
R A
RA
Genin
M J
MJ
Biles
C
C
Busso
M
M
Resnick
L
L
Althaus
I W
IW
Reusser
F
F
Thomas
R C
RC
Tarpley
W G
WG
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D020008:Delavirdine; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D007211:Indoles; D010879:Piperazines; D018894:Reverse Transcriptase Inhibitors; D020008:Delavirdine