In vivo genotoxic effects of smoking and occupational lead exposure in printing press workers.
The objective of the present study was to evaluate the genotoxicity of a combination exposure to lead and smoking in workers from the printing industry and also to examine the possible interaction between the two agents. Individuals were classified into 4 different groups: control group, lead-exposed group, smokers and the double-exposure group. Chromosomal analysis was carried out according to conventional methods. Our preliminary study shows that lead-exposed individuals had a significantly increased frequency of sister chromatid exchanges. Further, double exposure to smoking and lead inhibits mitosis.
Rajah
T
T
Department of Genetics, Osmania University, Hyderabad, India.
Ahuja
Y R
YR
D000328:Adult; D006801:Humans; D007854:Lead / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016296:Mutagenesis; D016273:Occupational Exposure / Q000009:adverse effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D012907:Smoking / Q000235:genetics*
D007854:Lead