Biomagnetic neurosensors. 3. Noninvasive sensors using magnetic stimulation and biomagnetic detection.
A noninvasive biomagnetic sensor system that uses magnetic toroids for both neural stimulation and detection is described. It is shown that analytical signals obtained by direct magnetic detection (no signal averaging) compare favorably with electrical monitoring and that dose-response curves for local anesthetics correlate well between the two methods. Neural lifetimes are significantly extended when the noninvasive biomagnetic sensing system is used.
Babb
C W
CW
Hawaii Biosensor Laboratory, Department of Chemistry, University of Hawaii, Honolulu 96822.
Coon
D R
DR
Rechnitz
G A
GA
D000200:Action Potentials; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D003400:Astacoidea / Q000502:physiology; D015374:Biosensing Techniques; D004305:Dose-Response Relationship, Drug; D004566:Electrodes; D008280:Magnetics; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects
D000779:Anesthetics, Local; D015222:Sodium Channels