title: Gene structure and expression in colorectal cancer.
abstract: Colorectal cancer provides a unique model for the study of molecular changes that are associated with tumorigenesis. The cancer evolves as an apparent ordered sequence from a benign to a malignant lesion in histopathological recognizable stages. Since it is relatively easy to isolate tissue representing each of these stages, studies of molecular events associated with tumor progression are feasible. Such studies have shown that multiple changes in gene structure, expression and activity occur during tumorigenesis.
authors.affiliation: Department of Biological Sciences, University of Pittsburgh, PA 15260.
authors.forename: J M
authors.initials: JM
authors.lastname: Pipas
authors.forename: K
authors.initials: K
authors.lastname: Pogue-Geile
authors.forename: G G
authors.initials: GG
authors.lastname: Finley
authors.forename: C A
authors.initials: CA
authors.lastname: Cartwright
authors.forename: A I
authors.initials: AI
authors.lastname: Meiesler
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000236:Adenoma / Q000235:genetics / Q000473:pathology; D002277:Carcinoma / Q000235:genetics / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc; D016391:Genes, src; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis / Q000235:genetics; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012269:Ribosomal Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D009363:Neoplasm Proteins; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; D012269:Ribosomal Proteins; D011505:Protein-Tyrosine Kinases; D016392:Proto-Oncogene Proteins pp60(c-src)