[Contractile activity and sensitivity of smooth muscle cells of the small intestine to agonists in acute ileus].
The impact of acute ileus on the contractility and sensitivity of small intestinal smooth muscle cells to acetylcholine and histamine, as well as possible recovery of smooth muscle cells after removal of 3-hour acute ileus were studied. The contractility of small intestinal smooth muscle cells and their sensitivity to the agonists decreased in proportion to the duration of acute ileus only in the strangulated portion of the bowel. Removal of 3-hour acute ileus resulted in a stepwise recovery of the contractility and sensitivity of small intestinal smooth muscle cells to the agonists in the adducting, strangulated, and abducting portions. It is suggested that in acute ileus, the structure of smooth muscle receptors undergo modification due to tissue homeostatic changes or to the direct action of cell destruction products on receptors.
Zaripov
N Z
NZ
Krasil'nikov
D M
DM
Chelyshev
Iu A
IuA
Akhmedzianov
R Kh
RKh
Sibaev
A K
AK
D000109:Acetylcholine / Q000494:pharmacology*; D000208:Acute Disease; D000818:Animals; D002415:Cats; D006632:Histamine / Q000494:pharmacology*; D007415:Intestinal Obstruction / Q000473:pathology / Q000503:physiopathology*; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
D006632:Histamine; D000109:Acetylcholine