Cognitive assessment of infants with West syndrome: how useful is it for diagnosis and prognosis?
Thirty-one infants with West syndrome were followed up. Their cognitive competence was assessed before the onset of the disease, and during and after the acute stage. Two kinds of cognitive impairment were identified: the first was transitory, linked to the acute stage and mainly consisting of arousal disturbances; the second was the well known long-term sequela. It is not possible to exclude the aetiological role of a persistent, severe epileptic change: however, this study emphasizes the prognostic value of previous mental impairment. In serial cognitive assessment during the acute stage, the progression of the developmental quotient was the best indicator of a good mental outcome, and vice versa.
Guzzetta
F
F
Istituto di Neuropsichiatria Infantile, Policlinico Universitario, Messina, Italy.
Crisafulli
A
A
Isaya Crinó
M
M
D001921:Brain / Q000503:physiopathology; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology*; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D011581:Psychological Tests; D011597:Psychomotor Performance; D012919:Social Behavior; D013036:Spasms, Infantile / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology