title: Production and structure of diabodies.
abstract: The first crystal structure of a diabody, a bivalent antibody fragment, confirms previous predicted structures and techniques for generating bispecific bivalent antibody fragments of considerable therapeutic potential.
authors.affiliation: Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville 20850.
authors.forename: R J
authors.initials: RJ
authors.lastname: Poljak
mesh_terms: D000595:Amino Acid Sequence; D001666:Binding Sites, Antibody; D006825:Hybridomas; D007128:Immunoglobulin Fragments / Q000096:biosynthesis* / Q000737:chemistry / Q000276:immunology; D007135:Immunoglobulin Variable Region; D008969:Molecular Sequence Data; D011487:Protein Conformation
chemical_list: D007128:Immunoglobulin Fragments; D007135:Immunoglobulin Variable Region