title: Effect of secretion on vagal stimulation-evoked exocrine pancreatic secretion in the rat.
abstract: The effect of secretin on nerve-mediated pancreatic juice secretion in the anaesthetized rat has been studied. Vagotomy caused a significant reduction in the rate of pancreatic juice flow, total protein output and amylase secretion being compared to control values prior to vagotomy. Both secretin (intravenous infusion 10(-10) mol/kg body weight/h) and electrical stimulation of the vagus nerves (4 V, 2 ms, 20 Hz) caused marked increases in flow, total protein output and amylase output. Pretreatment of rats with atropine (0.1 mg/kg body weight) abolished the electrical stimulation-evoked secretion. However, simultaneous intravenous infusion of secretin and electrical stimulation did not yield either a clear additive response or a potentiation of secretory responses.
authors.affiliation: Departamento de Fisiología, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Wisdom
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: P J
authors.initials: PJ
authors.lastname: Camello
authors.forename: J A
authors.initials: JA
authors.lastname: Pariente
authors.forename: G M
authors.initials: GM
authors.lastname: Salido
mesh_terms: D000681:Amylases / Q000378:metabolism; D000758:Anesthesia; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D008297:Male; D010179:Pancreas / Q000378:metabolism / Q000502:physiology*; D010189:Pancreatic Juice / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar / Q000502:physiology; D012633:Secretin / Q000502:physiology*; D012636:Secretory Rate / Q000502:physiology; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D012633:Secretin; D000681:Amylases