[The oxidative metabolic systems of the liver in exposure to maninil and obzidan].
The effects of maninile and obsidan and their combined action on metabolic processes were studied in a series of in vitro experiments. The metabolic processes serve as a prerequisite to energy supply and couple the anabolic and catabolic pathways of hepatic metabolism. The rate of aerobic and anaerobic oxidation of glucose was shown to decrease when maninile was in close contact with liver tissue. It is indicative of the indirect hypoglycemic action of maninile. There is evidence for the combined use of maninile and obsidan since it allows the balance of regulatory metabolites to be maintained. Also, metabolic changes became less if they were used in combination rather alone.
Gil'miiarova
F N
FN
Morugova
T V
TV
Kamilov
F Kh
FKh
Lazareva
D N
DN
Radomskaia
V M
VM
Vinogradova
L N
LN
Babichev
A V
AV
Kretova
I G
IG
D000818:Animals; D004347:Drug Interactions; D005905:Glyburide / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats
D011433:Propranolol; D005905:Glyburide