title: A nitro analogue of staurosporine and other minor metabolites produced by a Streptomyces longisporoflavus strain.
abstract: From the staurosporine-producing strain Streptomyces longisporoflavus R-19 various minor metabolites were isolated: They include a new compound with a nitro function in C-4' and other metabolites related to staurosporine. The new structures were elucidated by spectroscopic methods, mainly 1H NMR and 13C NMR and by comparison with TAN-1030A. The new compounds inhibited protein kinase C with IC50 values in the nanomolar range.
authors.affiliation: Pharmaceutical Research Department, CIBA-GEIGY Ltd, Basle, Switzerland.
authors.forename: Y
authors.initials: Y
authors.lastname: Cai
authors.forename: A
authors.initials: A
authors.lastname: Fredenhagen
authors.forename: P
authors.initials: P
authors.lastname: Hug
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry / Q000302:isolation & purification; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D016339:Spectrometry, Mass, Fast Atom Bombardment; D019311:Staurosporine; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D017672:Nitrogen Compounds; D011493:Protein Kinase C; D019311:Staurosporine