Characterization of a unique retroviral recombinant containing 7S L sequences.
Using a recently described system to generate recombinants between avian leukosis viruses (ALV) and cellular neo mRNA (A.M. Hajjar and M.L. Linial, J. Virol. 67:3845-3853, 1993), we isolated a recombinant containing 7S L sequences. Analysis of this recombinant revealed that it most likely arose during reverse transcription of three copackaged RNAs: 7S L RNA, neo RNA, and ALV genomic RNA. Reverse transcription appears to have initiated on the 7S L RNA. A model for the generation of this recombinant is described.
Hajjar
A M
AM
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Linial
M L
ML
D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D001483:Base Sequence; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011784:Quail; D012313:RNA / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D014158:Transcription, Genetic
D012367:RNA, Viral; C039919:RNA, recombinant; D012313:RNA