title: Dystrophic calcinosis of the penis.
abstract: A 22-year-old man had had a dome-shaped tumor on his penis for one year. Neither his particular past history nor family history was available. The excised specimen contained numerous von Kossa-positive deposits. Four types of histologic pattern were identified: 1) a cystic structure filled with amorphous material lined by a few layers of epithelial cells, 2) a cyst containing calcified deposits in the keratinous material, 3) a large calcified nodule lined by attenuated epithelial cyst walls, 4) numerous calcium collections without an epithelial wall. The cystic structure showed the histologic features of syringoma or sweat duct milia. The luminal cells of the cyst showed positive immunoreactivity for both keratin and carcinoembryonic antigen. These findings suggested that the keratinous contents of syringoma had gradually calcified, the cyst wall had been attenuated, and, finally, numerous calcium collections without an epithelial wall were formed. Our case further supported the hypothesis that penile calcinosis as well as scrotal calcinosis might derive from syringoma.
authors.affiliation: Department of Dermatology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Katoh
authors.forename: K
authors.initials: K
authors.lastname: Okabayashi
authors.forename: S
authors.initials: S
authors.lastname: Wakabayashi
authors.forename: S
authors.initials: S
authors.lastname: Kishimoto
authors.forename: H
authors.initials: H
authors.lastname: Yasuno
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003238:Connective Tissue / Q000473:pathology; D003560:Cysts / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D010409:Penile Diseases / Q000473:pathology*; D013545:Sweat Glands / Q000473:pathology
chemical_list: D002272:Carcinoembryonic Antigen; D007633:Keratins