Heteromorphism of human chromosome 18 detected by fluorescent in situ hybridization.
The individual variations of pericentromeric heterochromatin in human chromosome 18 were analysed using the C-banding techniques and nonradioactive fluorescence in situ hybridization (FISH) with chromosome 18 alpha-satellite DNA probe. FISH analysis shows heteromorphisms almost undetectable by C-banding and which regularly segregate in a family.
Bonfatti
A
A
Institute of Medical Genetics USL 31, Ferrara, Italy.
Giunta
C
C
Sensi
A
A
Gruppioni
R
R
Rubini
M
M
Fontana
F
F
D002871:Chromosome Banding; D002887:Chromosomes, Human, Pair 18 / Q000648:ultrastructure*; D015342:DNA Probes; D004276:DNA, Satellite / Q000648:ultrastructure; D005260:Female; D006570:Heterochromatin / Q000648:ultrastructure*; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008677:Metaphase; D013050:Spectrometry, Fluorescence
D015342:DNA Probes; D004276:DNA, Satellite; D006570:Heterochromatin