[Intergroup differences in anticlastogenesis].
The paper deals with the mechanisms of anticlastogenesis protection of chromosomes in cultured human cells, which depend on many external and internal factors and may vary in genetic risk groups and in individuals. It also analyzes the role of repair and metabolic disturbances in the observed inter- and intragroup differences in the efficiency of protective action in model test systems. Results of comparative analysis of the efficiency of various interferons in the cultured cells from patients with bronchial asthma are presented. The paper first provides evidence for attenuated protective effects in the cultured lymphocytes from patients with xeroderma pigmentosum or chronic recurrent urticaria as compared to those from healthy donors. Prospects of and optimal methodological approaches to the study of anticlastogenesis in human cells are discussed.
Arutiunian
R M
RM
Sarkisian
T F
TF
D016587:Antimutagenic Agents / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D002877:Chromosomes, Human / Q000187:drug effects*; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D016587:Antimutagenic Agents; D009153:Mutagens; D007372:Interferons