Immunohistochemical study of hemangioblastoma with special reference to its cytogenesis.
The cytogenesis of so-called hemangioblastoma arising in the central nervous system was investigated using the immunoreactivity to various proteins in cerebellar hemangioblastomas, extracerebellar hemangioblastomas, cerebral hemangiopericytomas, and hemangioendotheliomas, as well as a variety of meningiomas. The antisera used included vimentin, glial fibrillary acidic protein, epithelial membrane antigen, factor VIII-related antigen, and cytokeratin. Lipid-laden cells often encountered in partially degenerated meningiomas revealed almost identical reactivity patterns as the lipid-laden cells, i.e., so-called stroma cells, of hemangioblastomas. The results indicate that the so-called hemangioblastoma of the central nervous system is derived from arachnoid cells in meningotheliomatous meningiomas by way of cellular degeneration.
Mizuno
J
J
Department of Neurological Surgery, Aichi Medical University, Japan.
Iwata
K
K
Takei
Y
Y
D000328:Adult; D000368:Aged; D001921:Brain / Q000166:cytology* / Q000276:immunology* / Q000473:pathology; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D005260:Female; D018325:Hemangioblastoma / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007106:Immune Sera / Q000145:classification; D007150:Immunohistochemistry; D008297:Male; D008579:Meningioma / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D017154:Stromal Cells / Q000166:cytology
D007106:Immune Sera