title: Influence of silicone oil on iris microangiopathy in diabetic vitrectomized eyes.
abstract: OBJECTIVE
  This study evaluates the influence of intraocular silicone oil on iris diabetic microangiopathy in diabetic vitrectomized eyes.
  
  
  METHODS
  The authors examined 20 eyes of 20 patients with diabetes undergoing primary vitrectomy for fractional diabetic retinal detachment, endophotocoagulation, and 1000 centistokes silicone oil tamponade. The vascular status of the iris in these eyes was examined by iris fluorescein angiography once before silicone oil injection and again when it was removed (mean follow-up, 8.3 months).
  
  
  RESULTS
  Iris diabetic microangiopathy, including breakdown of the blood-iris barrier and iris neovascularization, improved or remained stable in 40% of eyes. It worsened in 60% of eyes, including all aphakic eyes. Neovascular glaucoma developed in one of them. A significant correlation was found between worsening of iris diabetic microangiopathy and both aphakia (P = 0.01) and severe immediate postvitrectomy inflammation (P = 0.02). Eyes with recurrent retinal detachment (n = 4) showed worsening of iris diabetic microangiopathy, but this was not significantly correlated.
  
  
  CONCLUSIONS
  Aphakic vitrectomized eyes have a higher risk of iris diabetic microangiopathy developing, even after silicone oil tamponade. Immediate postoperative intraocular inflammation also is a risk factor for worsening of iris diabetic microangiopathy in phakic eyes. Recurrence of retinal detachment was not significantly correlated with worsening of iris status.
authors.affiliation: Department of Ophthalmology and Visual Sciences H.S. Raffaele, University of Milano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Azzolini
authors.forename: R
authors.initials: R
authors.lastname: Brancato
authors.forename: F I
authors.initials: FI
authors.lastname: Camesasca
authors.forename: M
authors.initials: M
authors.lastname: Codenotti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D048909:Diabetes Complications; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000517:prevention & control*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007498:Iris / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery*; D012827:Silicone Oils; D014821:Vitrectomy
chemical_list: D012827:Silicone Oils