title: Low-dose intrathecal clonidine releases tachykinins in rat spinal cord.
abstract: In decerebrate, spinalized, unanesthetized rats, 37 pmol (10 ng) intrathecally injected clonidine facilitated the flexor reflex. This effect was blocked by the specific tachykinin antagonists CP-96,345, which acts at the NK1 receptor, and Men 10207, which acts at the NK2 receptor. Thus, low-dose intrathecal clonidine releases the tachykinins substance P and neurokinin A in the spinal cord.
authors.affiliation: Karolinska Institute, Department of Clinical Physiology, Huddinge, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Luo
authors.forename: Z
authors.initials: Z
authors.lastname: Wiesenfeld-Hallin
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D003655:Decerebrate State; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007278:Injections, Spinal; D015288:Neurokinin A / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism; D013373:Substance P / Q000378:metabolism*
chemical_list: D001713:Biphenyl Compounds; D006993:Hypnotics and Sedatives; D010446:Peptide Fragments; C063615:neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-; D013373:Substance P; D015288:Neurokinin A; D003000:Clonidine; C066892:CP 96345