Urinary bladder carcinoma producing granulocyte colony stimulating factor (G-CSF): a case report with immunohistochemistry.
A rare case of urinary bladder carcinoma with granulocyte colony stimulating factor (G-CSF) production was reported. In an 83-year-old female, marked neutrophilia in the peripheral blood decreased from 132,500/mm3 to 3,300/mm3 after tumour resection. The tumour was a transitional cell carcinoma. The serum G-CSF level reduced from 238 pg/ml pre-operatively to normal (60 pg/ml) after the operation. Immunohistochemical investigation of the resected tumour with monoclonal antibody specific for G-CSF revealed positive staining in the carcinoma cells, confirming G-CSF secretion.
Ito
T
T
Division of Internal Medicine, Nippon Kokan Hospital, Kanagawa, Japan.
Shimamura
K
K
Shoji
K
K
Akatsuka
A
A
Kiryu
Y
Y
Tamaoki
N
N
Osamura
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology
D016179:Granulocyte Colony-Stimulating Factor