Skin scoring in systemic sclerosis: a modification--relations to subtypes and the aminoterminal propeptide of type III procollagen (PIIINP).
Forty-one patients with systemic sclerosis were investigated with a new and simple skin score method measuring the degree of thickening and pliability in seven regions together with area involvement in each region. The highest values were, as expected, found in diffuse cutaneous systemic sclerosis (type III SS) and the lowest in limited cutaneous systemic sclerosis (type I SS) with no lesions extending above wrists and ancles. A positive correlation was found to the aminoterminal propeptide of type III procollagen, a serological marker for synthesis of type III collagen. The skin score is considered simpler than previous methods and is recommended for more general use.
Zachariae
H
H
Department of Dermatology, Marselisborg Hospital, University of Aarhus, Denmark.
Bjerring
P
P
Halkier-Sørensen
L
L
Heickendorff
L
L
Søndergaard
K
K
D001132:Arm; D015415:Biomarkers / Q000097:blood; D005385:Fingers; D005528:Foot; D006225:Hand; D006257:Head; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D018583:Pliability; D011347:Procollagen / Q000097:blood*; D012594:Scleroderma, Localized / Q000097:blood / Q000145:classification / Q000473:pathology; D012595:Scleroderma, Systemic / Q000097:blood* / Q000145:classification / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D013909:Thorax
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide