title: No effect of dietary fish oil on renal hemodynamics, tubular function, and renal functional reserve in long-term renal transplant recipients.
abstract: Dietary supplementation with fish oil rich in n-3 polyunsaturated fatty acids has been suggested to protect the kidney against cyclosporin A (CsA) toxicity. This study investigated the effects of a 10-wk dietary supplementation with fish oil on renal function and renal functional reserve in healthy volunteers (N = 9) and two groups of stable long-term kidney-transplanted patients treated with maintenance low-dose CsA (3.0 +/- 0.6 mg/kg; N = 9) or without CsA (N = 9). After an overnight fast, the subjects were water loaded, and clearance studies were performed, postponing morning medication. GFR and effective RPF were measured as the renal clearances of (99mTc)DTPA and (131I)hippuran, respectively. Renal tubular function was evaluated by use of the renal clearance of lithium and the urinary excretion of beta 2-microglobulin. Fish oil did not change baseline values of effective RPF, GFR, lithium clearance, and urinary excretion of beta 2-microglobulin in any of the groups. The infusion of amino acids induced a comparable increase in GFR, lithium clearance, and the urinary excretion rate of beta 2-microglobulin in all three groups with no additional effect of fish oil. Thus, long-term renal transplant recipients treated with a low maintenance dose of CsA had a well-preserved renal functional reserve, and dietary supplementation with fish oil in these patients did not improve renal function.
authors.affiliation: Department of Clinical Physiology, Herlev Hospital, University of Copenhagen, Denmark.
authors.forename: J M
authors.initials: JM
authors.lastname: Hansen
authors.forename: H
authors.initials: H
authors.lastname: Løkkegaard
authors.forename: C E
authors.initials: CE
authors.lastname: Høy
authors.forename: N
authors.initials: N
authors.lastname: Fogh-Andersen
authors.forename: N V
authors.initials: NV
authors.lastname: Olsen
authors.forename: S
authors.initials: S
authors.lastname: Strandgaard
mesh_terms: D000328:Adult; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012079:Renal Circulation / Q000187:drug effects*; D013997:Time Factors
chemical_list: D004042:Dietary Fats, Unsaturated; D005395:Fish Oils