Histological and mucin secretion patterns in solitary rectal ulcer syndrome.
OBJECTIVE
Histological and mucin secretion patterns were studied in 32 cases of solitary rectal ulcer syndrome.


METHODS
Biopsy sections stained with hematoxylin and eosin, Masson's trichrome and alcian blue with PAS at pH 1.0 and pH 2.5 were examined.


RESULTS
Fibrosis and smooth muscle extension in lamina propria and hypertrophy of muscularis mucosa were the most frequent histological findings. Sialomucin was present in all cases, in contrast to sulphomucin which is normally present.


CONCLUSIONS
Mucin staining pattern appears to be a helpful diagnostic marker of solitary rectal ulcer syndrome and may be helpful in differentiating it from other non-malignant conditions.
Khan
E M
EM
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.
Pandey
R
R
D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D009077:Mucins / Q000032:analysis / Q000378:metabolism*; D012002:Rectal Diseases / Q000473:pathology*; D052116:Sialomucins; D013194:Staining and Labeling; D014456:Ulcer / Q000473:pathology
D009077:Mucins; D052116:Sialomucins