title: Angioscotomata and morphological features of related vessels in automated perimetry.
abstract: OBJECTIVE
  To determine principles which regulate the occurrence of angioscotomata in automated static perimetry, variations in light sensitivity were correlated with the location and diameter of neighbouring retinal vessels.
  
  
  METHODS
  Ten normal eyes were tested with the Octopus 2000R, using a 0.431 degree light stimulus. Sensitivity was quantified in points located around the blind spot, according to a regular, 0.5 degree constant, grid pattern. From 336 to 443 locations were tested in each eye. The resulting printouts were superimposed on corresponding fundus photographs. At each tested point, the following five additional variables were evaluated: the diameters of the closest and the second closest vessel (in 0.1 degree units); the distances of the apparent location of the tested point to the closest and the second closest vessel (in 0.25 degree units); and the distance between the two closest vessels (in 0.25 degree units). Altogether, 3869 locations were tested and 23,214 values were quantified.
  
  
  RESULTS
  The following two conditions were found to be related to a reduction in sensitivity: (1) proximity (< 0.25 degree) to a large vessel (> or = 0.5 degree in diameter); (2) proximity (< 0.25 degree) to one of two adjacent (< 0.5 degree distant), moderately large vessels (0.3 degree to 0.4 degree in diameter). In condition 1, sensitivity was 51.3% and specificity was 92.2%; in condition 2, sensitivity was 16.2% and specificity was 98.3%; and with a combination of conditions 1 and 2, sensitivity was 67.6% and specificity was 90.5%. Increase by 0.1 degree of an adjacent vessel which was 0.4 degree in diameter markedly affected light sensitivity.
  
  
  CONCLUSIONS
  Modifications in vessel diameter are observed in a number of circumstances, including adaptive vascular response to changes in ambient conditions and obstructive disorders of retinal vessels. These findings indicate that changes in vessel diameter over time can result in fluctuation of sensitivity. It is concluded that, in contrast with what is commonly stated, when ocular media are unaltered and the subject's collaboration is adequate, temporal variations in measured thresholds do not necessarily reflect functional changes in nervous tissues in the visual pathways.
authors.affiliation: Department of Ophthalmology, Geneva University Hospital, Switzerland.
authors.forename: A B
authors.initials: AB
authors.lastname: Safran
authors.forename: A
authors.initials: A
authors.lastname: Halfon
authors.forename: E
authors.initials: E
authors.lastname: Safran
authors.forename: C
authors.initials: C
authors.lastname: Mermoud
mesh_terms: D000328:Adult; D006801:Humans; D008027:Light; D011237:Predictive Value of Tests; D012171:Retinal Vessels / Q000473:pathology*; D012607:Scotoma / Q000473:pathology* / Q000503:physiopathology; D014785:Vision, Ocular; D058609:Visual Field Tests