title: Primary sensory afferents in the thymus of the guinea pig demonstrated with anterogradely transported horseradish peroxidase conjugates.
abstract: After injections of wheat germ agglutinin- or B-subunit of cholera toxin-horseradish peroxidase (HRP) conjugates into the C2-C4 dorsal root ganglia of the guinea pig and anterograde axonal transport of the conjugates, labeled nerve fibers were found in the thymus mainly on the ipsilateral side. The distribution of the HRP-labeled fibers was similar to that of nerves immunoreactive to substance P and calcitonin gene-related peptide, which were partly colocalized. The results show that the thymus is innervated by primary sensory afferents which have their cell bodies in dorsal root ganglia.
authors.affiliation: Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
authors.forename: L G
authors.initials: LG
authors.lastname: Elfvin
authors.forename: H
authors.initials: H
authors.lastname: Aldskogius
authors.forename: J
authors.initials: J
authors.lastname: Johansson
mesh_terms: D000344:Afferent Pathways / Q000033:anatomy & histology*; D000818:Animals; D001370:Axonal Transport; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis; D002772:Cholera Toxin; D007839:Functional Laterality; D005727:Ganglia, Spinal / Q000033:anatomy & histology*; D006168:Guinea Pigs / Q000033:anatomy & histology; D006735:Horseradish Peroxidase; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000166:cytology; D009412:Nerve Fibers / Q000648:ultrastructure; D009475:Neurons, Afferent / Q000166:cytology*; D013373:Substance P / Q000032:analysis; D013950:Thymus Gland / Q000294:innervation*; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
chemical_list: D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; C052635:cholera toxin, B subunit-horseradish peroxidase; D013373:Substance P; D002772:Cholera Toxin; D006735:Horseradish Peroxidase; D015740:Calcitonin Gene-Related Peptide