Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats.
Recombinant rat gamma-interferon was found to inhibit collagen accumulation induced by the intratracheal administration of bleomycin in rat lungs. gamma-Interferon also elicited a reduction in histamine content in the lungs of the bleomycin-treated rats; however, this agent did not cause any obvious changes in inflammatory cell infiltration into the lung. These results suggest that gamma-interferon inhibits the development of pulmonary fibrosis by suppressing collagen synthesis and could thus be used as a therapeutic agent for preventing this condition.
Okada
T
T
Department of Physiology, Aichi Medical University, Japan.
Sugie
I
I
Aisaka
K
K
D000818:Animals; D001761:Bleomycin; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000187:drug effects; D006632:Histamine / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects; D008297:Male; D009929:Organ Size; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins / Q000494:pharmacology
D011994:Recombinant Proteins; D001761:Bleomycin; D006632:Histamine; D007371:Interferon-gamma; D003094:Collagen