5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells.
Effects of 5-hydroxyindole (5-OHi) on 5-HT3 receptor-operated ion current were investigated in voltage-clamped N1E-115 neuroblastoma cells. In the presence of 1 mM 5-OHi, the amplitudes of inward currents induced by the agonists 5-hydroxytryptamine (5-HT), 2-methyl-5-HT and dopamine were enhanced and desensitization of the responses was markedly slowed down. The results indicate that 5-OHi selectively modifies the desensitization of the 5-HT3 receptor-mediated ion current.
Kooyman
A R
AR
Research Institute of Toxicology, Utrecht University, The Netherlands.
van Hooft
J A
JA
Vijverberg
H P
HP
D000818:Animals; D007211:Indoles / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009447:Neuroblastoma; D011985:Receptors, Serotonin / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D007211:Indoles; D007473:Ion Channels; D011985:Receptors, Serotonin; C026785:5-hydroxyindole