Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).
We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection. The patient suffered no side effects, and use of G-CSF represents an important addition to the management of a life-threatening drug reaction.
Collins
D A
DA
Department of Rheumatology, St George's Hospital, London.
Tobias
J H
JH
Hill
R P
RP
Bourke
B E
BE
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*
D006052:Gold Sodium Thiomalate; D016179:Granulocyte Colony-Stimulating Factor