Human macrophage colony-stimulating factor levels in cerebrospinal fluid.
Macrophage colony-stimulating factor (M-CSF) levels in the cerebrospinal fluid of 14 patients with meningitis and of 14 patients suffering from a disease other than meningitis were measured using an enzyme-linked immunosorbent assay. All four bacterial meningitis patients had M-CSF levels in the cerebrospinal fluid which exceeded 1540 U/ml, and the mean value was 3333 +/- 1481 U/ml. The mean M-CSF level in the cerebrospinal fluid of the ten aseptic meningitis patients was 393 +/- 175 U/ml, which was higher than that of patients who suffered from a disease other than meningitis (179 +/- 90 U/ml) (P < 0.01). There was no clear correlation between the M-CSF levels and the numbers of white blood cells, granulocytes, or monocytes in the cerebrospinal fluid. These elevated M-CSF levels were thought to be of a local origin, since most patients with high M-CSF levels in the cerebrospinal fluid had relatively low M-CSF levels in the serum.
Shimoda
K
K
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Okamura
S
S
Mizuno
Y
Y
Harada
N
N
Kubota
A
A
Yamada
M
M
Hara
T
T
Aoki
T
T
Akeda
H
H
Ueda
K
K
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D016179:Granulocyte Colony-Stimulating Factor / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood / Q000134:cerebrospinal fluid*; D008582:Meningitis, Aseptic / Q000097:blood / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid*; D008583:Meningitis, Haemophilus / Q000097:blood / Q000134:cerebrospinal fluid; D008586:Meningitis, Pneumococcal / Q000097:blood / Q000134:cerebrospinal fluid; D013997:Time Factors
D015415:Biomarkers; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor