[Modification of cortical and trabecular mineral density of the femur, induced by ipriflavone therapy, Clinical results after 12 months].
In order to evaluate the effects of ipriflavone therapy, a clinical and metabolic study was carried out in a group of female patients with low bone mass. In particular, mineral density of the proximal femur was measured, this being a fundamental factor for the resistance of this district. At the end of the 12-months treatment cycle, reduced plasma concentration of Bone Gla Protein and urinary hydroxyproline/creatinine ratio (indicating reduced bone resorption), and a significant increase of bone density of the femoral neck and of the trabecular substructure of Ward's triangle were found. On the whole, treatment was well tolerated.
Fiore
C E
CE
Clinica Medica L. Condorelli, Università degli Studi di Catania.
Gibilaro
M
M
Motta
M
M
Foti
R
R
Dieli
M
M
D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D001862:Bone Resorption / Q000517:prevention & control; D005260:Female; D005264:Femoral Fractures / Q000209:etiology* / Q000517:prevention & control; D005265:Femoral Neck Fractures / Q000209:etiology / Q000517:prevention & control; D005269:Femur / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D012307:Risk Factors
D007529:Isoflavones; C018986:ipriflavone