[Effects of PGE1 on pulmonary arterial and venous flow in elderly patients--evaluation by transesophageal Doppler echocardiography].
Effects of PGE1 on pulmonary arterial and venous flow were evaluated noninvasively with transesophageal Doppler echocardiography in 13 elderly patients (70-79 years old), and the results were compared with those in control group of 13 patients (20-48 years old). In control group, infusion of PGE1 at a rate of 20 ng.kg-1.min-1 decreased pulmonary arterial pressure significantly, but not in elderly patients even at a rate of 50 ng.kg-1.min-1. In elderly patients, effects of PGE1 were more remarkable for afterload reduction than preload, so that cardiac output was maintained without change in stroke volume and heart rate, but with increase of heart rate in control patients. From our results, it is concluded that PGE1 may have less effect on pulmonary hemodynamics in elderly patients.
Kawahito
S
S
Department of Anesthesiology, Tokushima University School of Medicine.
Kitahata
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000527:Alprostadil / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D017548:Echocardiography, Transesophageal; D006801:Humans; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects*
D000527:Alprostadil