[In vitro antifungal activities of lanoconazole against stock cultures and clinical isolates of Candida albicans].
In vitro antifungal activities of lanoconazole (LCZ) against 9 stock cultures and 10 clinical isolates of Candida albicans were determined using three different testing media, Sabouraud's glucose broth (SGB), Sabouraud's glucose agar (SGA) and casitone agar (CA). MIC values of LCZ against both the stock cultures and clinical isolates measured on CA distributed in a range of 0.63-5 micrograms/ml. The values were 8-64-fold lower than those obtained in SGB and on SGA. MIC ranges and the geometric mean MIC values of LCZ against stock cultures were virtually the same as those against clinical isolates, no matter which assay techniques were used. These results suggest that there is no difference in the LCZ susceptibility between stock cultures and clinical isolates of C. albicans, although anti-Candida activity of LCZ was determined to be greater on CA than that in SGB or on SGA.
Niwano
Y
Y
Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd.
Ohmi
T
T
Kanai
K
K
Hamaguchi
H
H
Uchida
K
K
Yamaguchi
H
H
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D007093:Imidazoles; C072774:latoconazole