Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria.
Interactions of FK 506 with renal cortical mitochondria have been investigated by measuring respiration, ATP net uptake and Ca2+/Pi-induced swelling. Both FK 506 and cyclosporin A (CsA) inhibit the succinate-supported state 3 and uncoupled respiration and are without effect on the glutamate/malate-supported state 3 and uncoupled respiration. FK 506, like CsA, inhibits net uptake of ATP, but, in contrast to CsA, is without effect on Ca2+/Pi-induced swelling.
Henke
W
W
Research Division, Medical Faculty (Charité), Humboldt-University Berlin, Germany.
Jung
K
K
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D016572:Cyclosporine / Q000633:toxicity*; D007672:Kidney Cortex / Q000187:drug effects*; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000473:pathology; D010101:Oxygen Consumption / Q000187:drug effects; D010710:Phosphates / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016559:Tacrolimus / Q000633:toxicity*
D010710:Phosphates; D016572:Cyclosporine; D000255:Adenosine Triphosphate; D002118:Calcium; D016559:Tacrolimus