title: Efficacy of new organic ammonium salts on Pseudomonas aeruginosa Salmonella typhimurium.
abstract: The inhibitory activities of four new homologous series of organic ammonium salts (OAS) were tested on bacterial strains isolated from patients. Two types of compounds are used: "hard" (group A) and three groups (B, C, D) of biodegradable "soft" OAS with metabolically labile CO or NH groups in their molecules. The strain Pseudomonas aeruginosa was isolated from the sputum of a patient with carcinoma. The strain Salmonella typhimurium was isolated from a patient with clinical diagnosis of diarrhea. In all homologous series, the antibacterial activity was increasing continuously with the length of alkyl chain up to dodecyl or tetradecyl, then the "cut off" effect was observed. The most active compounds from both "hard" and "soft" types had superior activity to commercial disinfectants. The strain of Pseudomonas aeruginosa was more sensitive to these compounds than that of Salmonella typhimurium.
authors.affiliation: Institute of Preventive and Clinical Medicine, J.A. Comenius University, Bratislava, Slovakia.
authors.forename: V
authors.initials: V
authors.lastname: Majtán
authors.forename: L
authors.initials: L
authors.lastname: Majtánová
authors.forename: D
authors.initials: D
authors.lastname: Mlynarcík
mesh_terms: D006801:Humans; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012478:Salmonella Food Poisoning / Q000382:microbiology; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000644:Quaternary Ammonium Compounds