Effects of physical activity on creatine phosphokinase and the isoenzyme creatine kinase-MB.
Creatine phosphokinase (CPK) and creatine kinase-MB (CK-MB) have been used extensively as diagnostic markers for myocardial infarction and skeletal muscle injury. Many factors affect the variability of serum CPK and serum CK-MB activity, especially physical activity. We discuss the influence of physical activity on muscle and serum CPK and CK-MB. The effect of acute and chronic exercise on CPK and CK-MB activity emphasizes the need to use measurements of serum CPK and CK-MB with caution when evaluating and diagnosing acute myocardial infarctions and skeletal muscle injury.
Schneider
C M
CM
Department of Kinesiology, University of Northern Colorado, Greeley.
Dennehy
C A
CA
Rodearmel
S J
SJ
Hayward
J R
JR
D000328:Adult; D000375:Aging / Q000502:physiology; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology*; D012727:Sex Characteristics
D007527:Isoenzymes; D003402:Creatine Kinase