Characterization of an antigenic site on glycoprotein 13 (gC) of equid herpesvirus type-1.
Six monoclonal antibodies directed against EHV-1 glycoprotein 13 were characterized. Five antibodies neutralized EHV-1 and were directed against a single antigenic site which comprised type-specific and type cross-reactive epitopes. Inhibition of monoclonal antibody binding to this site by post-infection equine sera suggests that it is a target of host antibody during natural infection with either EHV-1 or EHV-4.
Sinclair
R
R
Department of Infectious Diseases, Animals Health Trust, Newmarket, Suffolk, England.
Moult
B J
BJ
Mumford
J A
JA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D006224:Cricetinae; D003429:Cross Reactions; D000939:Epitopes; D006023:Glycoproteins / Q000276:immunology*; D004861:Herpesvirus 1, Equid / Q000276:immunology*; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D014759:Viral Envelope Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D006023:Glycoproteins; D014759:Viral Envelope Proteins