Effects of TC7 associated to 32% dextran 70, heparin and carboxymethylcellulose in adhesion prevention in the rat.
Experimental studies on adhesion formation 90 days after laparotomy in the rat were done. Uterine horn adhesions after standardised procedures and trauma in a control group of 10 rats were compared with those obtained in six other 10-rat groups in whom heparin, carboxymethylcellulose (CMC), 32% dextran 70 and the fabric TC7 either alone or in various combinations were used at the time of laparotomy. Dextran 70 and CMC used on their own appeared to reduce adhesion formation but the improvement did not achieve statistical significance when compared with the control group. TC7 used alone had no anti-adhesion effect; when used with CMC or dextran 70, TC7 did not enhance the anti-adhesion benefit conferred by either substance used on its own.
Ortega-Moreno
J
J
Department of Animal Pathology, University of Zaragoza, Spain.
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology*; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects / Q000601:surgery*; D006493:Heparin / Q000494:pharmacology*; D008866:Microsurgery; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control; D014599:Uterus / Q000187:drug effects / Q000601:surgery
D002483:Cellulose, Oxidized; D003911:Dextrans; C060002:INTERCEED; D006493:Heparin; D002266:Carboxymethylcellulose Sodium