Positive-ion fast-atom bombardment tandem mass spectrometry of peptide nucleic acids.
The base sequence of synthetic peptide nucleic acids (PNAs), novel antisense agents, was analyzed by positive-ion fast-atom bombardment tandem mass spectrometry (FAB-MS/MS). Upon high-energy collisional activation decomposition, PNA oligomers provided apparent MS/MS product ions resulting from specific cleavage along the PNA backbone.
Takao
T
T
Institute for Protein Research, Osaka University, Japan.
Fukuda
H
H
Coull
J
J
Shimonishi
Y
Y
D001483:Base Sequence; D008969:Molecular Sequence Data; D009696:Nucleic Acids / Q000032:analysis* / Q000138:chemical synthesis; D010455:Peptides / Q000032:analysis* / Q000138:chemical synthesis; D016339:Spectrometry, Mass, Fast Atom Bombardment
D009696:Nucleic Acids; D010455:Peptides