title: Hyaluronan and hyaluronectin in the extracellular matrix of human brain tumour stroma.
abstract: Hyaluronan (HA) and the hyaluronan-binding glycoprotein hyaluronectin (HN) were measured in 23 gliomas and 8 meningiomas and their location was revisited in 35 tumours. A clear-cut difference was found in the HN/HA ratio values of glioblastomas (below 0.5) and that of astrocytomas (above 0.5 P < 0.001). Besides their location in the intercellular part of gliomas, HA and HN displayed a perivascular location in 1/3 astrocytomas, 17/24 glioblastomas, and 3/7 meningiomas, suggesting they could be produced also by the vascular stroma of tumours and that they would characterise the neoangiogenesis. All cultivated glioma cells tested produced HA in vitro, whereas only 1/11 cell lines produced HN, at a low level. The results obtained suggest that glioma HA and HN are produced by both cancer cells and vascular stroma cells, which contribute to the edification of the extracellular matrix. In meningiomas only the stroma would be responsible for HA and HN production.
authors.affiliation: Laboratoire d'Oncologie Moléculaire, Centre Henri-Becquerel, Rouen, France.
authors.forename: B
authors.initials: B
authors.lastname: Delpech
authors.forename: C
authors.initials: C
authors.lastname: Maingonnat
authors.forename: N
authors.initials: N
authors.lastname: Girard
authors.forename: C
authors.initials: C
authors.lastname: Chauzy
authors.forename: R
authors.initials: R
authors.lastname: Maunoury
authors.forename: A
authors.initials: A
authors.lastname: Olivier
authors.forename: J
authors.initials: J
authors.lastname: Tayot
authors.forename: P
authors.initials: P
authors.lastname: Creissard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000737:chemistry*; D002352:Carrier Proteins / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D016326:Extracellular Matrix Proteins / Q000737:chemistry*; D005260:Female; D005333:Fetus; D005910:Glioma / Q000737:chemistry; D006801:Humans; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid / Q000032:analysis*; D008297:Male; D008579:Meningioma / Q000737:chemistry; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000032:analysis*
chemical_list: D002352:Carrier Proteins; D016326:Extracellular Matrix Proteins; D018960:Hyaluronan Receptors; D011956:Receptors, Cell Surface; D006820:Hyaluronic Acid