Salvage of renal allograft function and lower extremity venous patency with thrombolytic therapy: case report and review of the literature.
Five months after a cadaveric renal transplants a 69-year-old man was admitted with caval, iliac, and renal allograft vein thrombosis that occurred in the setting of a previously placed caval filter. The patient's urine output and renal function deteriorated rapidly. Thrombolytic therapy with urokinase was begun, and lysis of the thrombus occurred in 72 hours. The patient's renal function returned to baseline, and the transplant was salvaged. Moreover lower extremity venous patency and valvular function were maintained. We report the case and review the literature on thrombolytic therapy for renal allograft vein and lower extremity deep venous thrombosis.
Killewich
L A
LA
Department of Surgery, University of Maryland, Baltimore 21201, USA.
Pais
S O
SO
Sandager
G
G
Flinn
W R
WR
Bartlett
S T
ST
D000368:Aged; D005268:Femoral Vein / Q000473:pathology; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000188:drug therapy; D006085:Graft Survival; D006801:Humans; D007084:Iliac Vein / Q000473:pathology; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D012082:Renal Veins / Q000473:pathology*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D014184:Transplantation, Homologous; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*; D014654:Vascular Patency; D016306:Vena Cava Filters; D014682:Vena Cava, Inferior / Q000473:pathology
D014568:Urokinase-Type Plasminogen Activator