The AMPA receptor antagonist NBQX does not alter the motor response induced by selective dopamine agonists in MPTP-treated monkeys.
We studied the motor response induced by the administration of the AMPA receptor antagonist, NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline(1H,4H)dione sodium salt), in two parkinsonian monkeys and its interaction with the selective D-2 dopamine receptor agonist, (+)-PHNO [(+)-4-propyl-9-hydroxynaphthoxazine], and the partial dopamine D-1 receptor agonist, CY 208-243 [(-)-4,6,6a,7,8,12b-hexahydro-7-methyl-indolo[4,3a-b]phen anthyxidine]. NBQX treatment did not reverse the parkinsonism or change the responses previously induced by dopamine agonists. These results do not support an antiparkinsonian effect of the AMPA receptor antagonist, NBQX. In addition they indicate that there is no functional interaction between AMPA and dopamine receptors in monkeys with a substantia nigra lesion.
Luquin
M R
MR
Department of Neurology, Clínica Universitaria de Navarra, Medical School, Pamplona, Spain.
Obeso
J A
JA
Laguna
J
J
Guillén
J
J
Martínez-Lage
J M
JM
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D007211:Indoles / Q000494:pharmacology; D008252:Macaca fascicularis; D009043:Motor Activity / Q000187:drug effects*; D010078:Oxazines / Q000494:pharmacology; D010300:Parkinson Disease / Q000188:drug therapy*; D010617:Phenanthridines / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology*; D018091:Receptors, AMPA; D017470:Receptors, Glutamate / Q000187:drug effects; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D015259:Dopamine Agents; D018691:Excitatory Amino Acid Antagonists; D007211:Indoles; D010078:Oxazines; D010617:Phenanthridines; D011810:Quinoxalines; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; C054531:CY 208-243; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; C042631:naxagolide; D007051:Ibotenic Acid; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine