Skin-selective lymphocyte homing mechanisms in the pathogenesis of leukemic cutaneous T-cell lymphoma.
The concept of skin-associated lymphoid tissue embraces those cells and functions that are integrated in the cutaneous host defense. Recently, it has been possible to identify those circulating T-cells that are skin associated. These cells display the cell-surface phenotype of memory T cells (CD45RO+) and express the cutaneous lymphocyte antigen, a tissue-selective homing receptor involved in directing T-cell traffic to inflamed skin. To investigate the participation of this skin-associated T-cell subset in the pathogenesis of cutaneous T-cell lymphoma, we studied 16 patients with erythrodermic cutaneous T-cell lymphoma for the presence of these surface proteins on circulating cells. Results were compared with eight patients in remission and eight with minimal patch-plaque cutaneous T-cell lymphoma. The mean expression of both CD45RO and cutaneous lymphocyte antigen were significantly greater in the erythrodermic patients than in the other two patient groups. Expression of these markers was shown to be on the cells of the malignant clone by two-color flow cytometry. These results demonstrate that the malignant cells of cutaneous T-cell lymphoma express the markers of skin homing lymphocytes and that their levels are increased in the erythrodermic cutaneous T-cell lymphoma patients. Moreover, the findings suggest a critical role for the skin-selective homing receptor cutaneous lymphocyte antigen in the pathogenesis of cutaneous T-cell lymphoma.
Heald
P W
PW
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
Yan
S L
SL
Edelson
R L
RL
Tigelaar
R
R
Picker
L J
LJ
D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis / Q000494:pharmacology; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000494:pharmacology; D019040:E-Selectin; D000939:Epitopes; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000209:etiology* / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000276:immunology / Q000502:physiology; D016410:Lymphoma, T-Cell, Cutaneous / Q000209:etiology / Q000276:immunology / Q000648:ultrastructure; D008562:Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D016201:Receptors, Lymphocyte Homing / Q000502:physiology*; D012878:Skin Neoplasms / Q000209:etiology* / Q000648:ultrastructure*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; C063419:CTAGE1 protein, human; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D000939:Epitopes; D008562:Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell; D016201:Receptors, Lymphocyte Homing; D017493:Leukocyte Common Antigens