[Cathepsin D activity in gastric cancer].
The levels of activity of cathepsin D were compared in neoplastic and normal gastric mucosa in 42 patients, aged 39-78, at different stages of the disease. A relationship was established between cathepsin D activity and main clinico-morphological characteristics of stomach tumor: cathepsin D activity was found to increase with decreasing differentiation and increasing depth of invasion and metastatic spreading of tumor tissue. Possible involvement of proteolytic enzymes and, in particular, an aspartyl proteinase--cathepsin D--in the mechanisms of invasion and metastatic spreading of neoplasms is discussed.
Kantsaliev
A L
AL
Kozyreva
E A
EA
Kushlinskiĭ
N E
NE
Rottenberg
V I
VI
Klimenkov
A A
AA
Vasil'ev
A V
AV
D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000201:enzymology / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D002402:Cathepsin D / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology / Q000473:pathology; D006652:Histological Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D013053:Spectrophotometry; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery
D002402:Cathepsin D