[Efficacy of ondansetron in radiation-induced nausea and vomiting: review of the literature].
Radiotherapy-induced emesis depends on the site of irradiation, the field size and the dose per fraction and is generally less intense than chemotherapy-induced emesis. Established anti-emetic drugs offer only limited symptom control (50%). Ondansetron, a 5HT3 receptors antagonist, had proven a complete or a major control efficacy (0-2 emetic episodes) of 68 to 95% in three pilot studies (fractionated, single-dose and total body irradiations). In controlled studies, ondansetron efficacy was significantly higher than placebo, metoclopramide and prochlorperazine. The treatment was well tolerated in the different studies.
Lévy
E
E
CHU Henri-Mondor, Créteil, France.
Paillarse
J M
JM
Votan
B
B
D006801:Humans; D009325:Nausea / Q000188:drug therapy* / Q000209:etiology; D017294:Ondansetron / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects*; D014839:Vomiting / Q000188:drug therapy* / Q000209:etiology
D017294:Ondansetron