Derivatives of 2-mercaptobenzenesulphonamide. XVII. Synthesis and some pharmacological properties of 1-[4-R-5-cyano-2-dialkylaminoalkylthio)benzenesulphonyl]-2-imidiazolidi none hydrochlorides.
Syntheses of 1-[4-R-5-cyano-2-(dialkylaminoalkylthio)-benzenesulphonyl]- 2-imidiazolidinones [IIIa-h,IVa-m] and their hydrochlorides [Va-h, VIa-m] are described herein. The results of preliminary pharmacological examinations, such as acute toxicity and influence on the circulatory system are presented. Some structure-activity relationship are also discussed.
Pomarnacka
E
E
Department of Drug Technology, School of Medicine, Gdańsk, Poland.
Brzozowski
Z
Z
Gajewski
F
F
Filczewski
M
M
Oledzka
K
K
Kosmala
M
M
Sliwoska
M
M
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004594:Electrophysiology; D006339:Heart Rate / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000378:metabolism*
D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; D013449:Sulfonamides