Detection of cardiovascular calcified deposits via tetracarboxylate ion dye (BTC) probing and laser-induced fluorescence spectroscopy.
In order to develop a reliable, laser-induced, fluorescence-guided, angioplasty system, fluorescence spectra were recorded during exposure of normal and atherosclerotic cadaveric aortic tissue to argon ion laser irradiation. A characteristic increase in the fluorescence signal in the 520-560 nm spectral region for atheromatous tissue was observed after treatment of the samples with a tetracarboxylate ion dye (BTC). This allowed the development of a simple algorithm (based on the intensity difference) and a subsequent index of discrimination between normal and atheromatous tissue. Our results suggest that monitoring of this index through the catheter could enhance selective ablation.
Papazoglou
T G
TG
Foundation for Research and Technology Hellas, Institute of Electronic Structure and Laser, Heraklion, Crete, Greece.
Iatridou
H
H
Foukaraki
E
E
Katerinopoulos
H E
HE
D000465:Algorithms; D001012:Aorta, Abdominal / Q000473:pathology*; D001161:Arteriosclerosis / Q000473:pathology*; D001344:Autopsy; D002102:Cadaver; D002114:Calcinosis / Q000473:pathology*; D002264:Carboxylic Acids; D005456:Fluorescent Dyes; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D012016:Reference Values; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods
D002264:Carboxylic Acids; D005456:Fluorescent Dyes