An immunohistochemical study of cathepsin E in Alzheimer-type dementia brains.
We studied the immunohistochemical localization of cathepsin E (cath E) in the brains of patients with Alzheimer disease (AD) and control brains. In the normal brain cathepsin E immunoreactivity was detectable in a small number (below 5%) of neocortical and hippocampal neurons. In AD brains cathepsin E antigen was revealed in most large cortical and hippocampal pyramids and in neurons of the Nuc. basalis of Meynert. Cathepsin E was also present in cerebral microvessels, microglia, and in senile plaques. The enzyme might play roles in the process of neurodegeneration taking place in AD.
Bernstein
H G
HG
Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, FRG.
Wiederanders
B
B
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology*; D020059:Cathepsin E; D002403:Cathepsins / Q000032:analysis*; D002540:Cerebral Cortex / Q000201:enzymology*; D006624:Hippocampus / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013377:Substantia Innominata / Q000201:enzymology*
D002403:Cathepsins; D020059:Cathepsin E