[The transplacental transit and action of ceftazidime on the fetus in an experiment on animals at different times of the pregnancy].
The experiments were conducted on pregnant albino rats to study the transplacental transit of ceftazidime (Fortum) to the fetus on days 14 and 21 of pregnancy after a single intramuscular injection of 100 mg/kg. The antibiotic transition was 5.23, and 51.94% on days 14 and 21, respectively. The total toxic and embryotoxic effects of ceftazidime were studied in pregnant albino rats given intramuscular injections of 100 and 500 mg/kg/day on days 9-20 of pregnancy. Ceftazidime was found to have neither negative effects on the maternal body and nor embryotoxic and teratogenic properties.
Kasabulatov
N M
NM
Sheveleva
G A
GA
Voropaeva
S D
SD
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D002442:Ceftazidime / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D002442:Ceftazidime