Circadian variation in plasma 5-hydroxyindoleacetic acid level during and after alcohol withdrawal: phase advances in alcoholic patients compared with normal subjects.
Alcohol withdrawal symptoms in 19 male alcoholics were objectively evaluated and classified and circadian variation in their plasma 5-hydroxyindoleacetic acid (5-HIAA) concentrations was determined at 3 different intervals after cessation of drinking. Circadian variations in plasma 5-HIAA level exhibited phase advances in alcoholic patients compared with normal controls and were different depending on the severity of alcohol withdrawal symptoms. Plasma 5-HIAA in patients with delirium tremens showed significantly higher levels during the abstention period, possibly suggesting peculiarity in their serotonergic metabolism.
Sano
H
H
Department of Psychiatry, Hamamatsu University School of Medicine, Japan.
Suzuki
Y
Y
Yazaki
R
R
Tamefusa
K
K
Ohara
K
K
Yokoyama
T
T
Miyasato
K
K
Ohara
K
K
D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000097:blood*; D000437:Alcoholism / Q000097:blood / Q000534:rehabilitation*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D006897:Hydroxyindoleacetic Acid