title: Laser nephelometric evaluation of albumin, IgG and alpha 2-macroglobulin: applications to the study of alterations of the blood-brain barrier.
abstract: Cerebrospinal fluid and serum levels of albumin, immunoglobulin G and alpha 2-macroglobulin were determined by laser nephelometer in various pathological conditions: Guillain-Barré syndrome amyotrophic lateral sclerosis, lumbar disc herniation. These proteins are different due to their molecular weight, spacial conformation, CSF and serum concentrations and their CSF/serum quotient reflects the status of the blood-brain barrier. In the subjects group comparisons, albumin quotient and IgG quotient show a significant differentiations. The linear regression of albumin quotient compared to alpha 2-macroglobulin quotient behaves differently in the individual groups. The protein CSF/serum quotients are helpful in distinguishing the causes of alterations in the blood-brain barrier.
authors.affiliation: Institute of Clinical Neurology, University of Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Meucci
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: Bettini
authors.forename: D
authors.initials: D
authors.lastname: Montanaro
authors.forename: L
authors.initials: L
authors.lastname: Gironelli
authors.forename: L
authors.initials: L
authors.lastname: Voci
authors.forename: F
authors.initials: F
authors.lastname: Bianchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis / Q000134:cerebrospinal fluid*; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier / Q000502:physiology*; D001923:Brain Chemistry; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000134:cerebrospinal fluid*; D007405:Intervertebral Disc Displacement / Q000134:cerebrospinal fluid; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid; D012044:Regression Analysis; D000511:alpha-Macroglobulins / Q000032:analysis / Q000134:cerebrospinal fluid*
chemical_list: D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G; D000511:alpha-Macroglobulins