title: Synthesis and inhibitory activities on platelet aggregation of some flavonoid analogues.
abstract: A series of 26 benzodioxan and benzodioxol derivatives of flavone have been prepared. The activity of the compounds on washed human platelet aggregation induced by adenosine diphosphate (ADP, 5 mumol/l), collagen (10 micrograms/ml) and calcimycin (20 mumol/l) was evaluated. The alkoxycarbonyl side chain derivatives inhibited all three types of aggregation inducers. Among the tested compounds Ia is the most potent inhibitor of collagen-induced aggregation but possesses a weak activity against the other two used inducers. The esters IIIb and in particular, IIIc are active against all the three used inducers. These results suggest that ethoxycarbonyl group is a potent substituent to provide the antiplatelet action in this series of flavonoids.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Göker
authors.forename: M
authors.initials: M
authors.lastname: Tunçbilek
authors.forename: G
authors.initials: G
authors.lastname: Leoncini
authors.forename: E
authors.initials: E
authors.lastname: Buzzi
authors.forename: M
authors.initials: M
authors.lastname: Mazzei
authors.forename: Y
authors.initials: Y
authors.lastname: Rolland
authors.forename: R
authors.initials: R
authors.lastname: Ertan
mesh_terms: D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors