A report of two cases of recurrent Paget's disease of the vulva in a split-thickness graft and its possible pathogenesis-labeled "retrodissemination".
Two cases of recurrent noninvasive Paget's disease of the vulva in a split-thickness graft without an underlying adenocarcinoma are presented. This is the third report of recurrence of extramammary Paget's disease in a split-thickness graft, and the second of such an occurrence without an underlying dermal adnexa adenocarcinoma. A hypothesis for the possible pathogenetic mechanism of this unusual biological behavior is suggested.
DiSaia
P J
PJ
Department of Obstetrics and Gynecology, University of California, Irvine Medical Center, Orange 92668, USA.
Dorion
G E
GE
Cappuccini
F
F
Carpenter
P M
PM
D000230:Adenocarcinoma / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D010145:Paget Disease, Extramammary / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D016038:Skin Transplantation / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery