title: Characterization and acute phase modulation of canine apolipoprotein H (beta 2-glycoprotein I).
abstract: Apolipoprotein H (ApoH) is a 50 kDa glycoprotein capable of binding to negatively charged phospholipids and is a probable inhibitor of the blood coagulation pathway, platelet aggregation, and platelet prothrombinase activity, as well as being involved in autoimmune disease. We have cloned and sequenced a full length ApoH cDNA clone from a beagle dog liver library. Its derived amino acid sequence shows high cross-species similarity to ApoH from other mammals. Canine ApoH mRNA expression is down regulated during an experimentally induced inflammatory response establishing that it is a negative acute phase reactant.
authors.affiliation: Department of Genetics, Trinity Biotechnology Institute, Trinity College, Dublin, Ireland.
authors.forename: G C
authors.initials: GC
authors.lastname: Sellar
authors.forename: J
authors.initials: J
authors.lastname: Keane
authors.forename: H
authors.initials: H
authors.lastname: Mehdi
authors.forename: M E
authors.initials: ME
authors.lastname: Peeples
authors.forename: N
authors.initials: N
authors.lastname: Browne
authors.forename: A S
authors.initials: AS
authors.lastname: Whitehead
mesh_terms: D000209:Acute-Phase Proteins / Q000235:genetics / Q000378:metabolism*; D000210:Acute-Phase Reaction; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004285:Dogs; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D053482:beta 2-Glycoprotein I
chemical_list: D000209:Acute-Phase Proteins; D006023:Glycoproteins; D012333:RNA, Messenger; D053482:beta 2-Glycoprotein I; D004247:DNA