title: [Neurologic complications in hypereosinophilia syndrome--a case report].
abstract: The idiopathic hypereosinophilic syndrome (HES) is a rare disease characterised by prolonged eosinophilia of undetectable cause and by the presence of varying internal symptoms and frequent neurological signs. We report on a 43-year old man with HES who developed cerebral infarction and organic psychosyndrome. Chemotherapy resulted in lower eosinophil counts and marked improvement of central nervous system dysfunction. We comment on possible pathophysiologic mechanisms of central nervous system involvement in HES.
authors.affiliation: Neurologisch-Psychiatrische Klinik, Städtischen Klinikums Braunschweig.
authors.forename: V
authors.initials: V
authors.lastname: Otto
mesh_terms: D000328:Adult; D001037:Aphasia / Q000175:diagnosis / Q000188:drug therapy; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000187:drug effects; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000188:drug therapy; D009460:Neurologic Examination / Q000187:drug effects
chemical_list: D003520:Cyclophosphamide; D008775:Methylprednisolone