Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation.
Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.
Temin
H M
HM
McArdie Laboratory, University of Wisconsin, Madison 53706.
D014644:Genetic Variation; D009154:Mutation; D012367:RNA, Viral / Q000096:biosynthesis*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D011995:Recombination, Genetic; D012190:Retroviridae / Q000502:physiology*; D017384:Sequence Deletion; D013698:Templates, Genetic; D014779:Virus Replication
D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase