Malignant germ cell tumours in two siblings.
Familial germ cell tumours are well recognised in kinship with gonadal dysgenesis, but their occurrence in siblings with normal chromosomes is rare. We report two sisters who presented within a 4 month period with malignant ovarian germ cell tumours; one a dysgerminoma and the other a mixed tumour with marked choriocarcinomatous elements. Both children had a normal female constitutional karyotype and normal phenotype.
Blake
K I
KI
Department of Paediatric Oncology, Children's Hospital, Sheffield, England.
Gerrard
M P
MP
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D002648:Child; D002822:Choriocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D004407:Dysgerminoma / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D009679:Nuclear Family; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery
D001761:Bleomycin; D005047:Etoposide; D016190:Carboplatin