title: Impact of aprotinin on blood transfusion requirements in liver transplantation.
abstract: A retrospective study was carried out to ascertain the blood bank provision required to support a liver transplant programme and to assess the effect of intraoperative aprotinin on blood product requirements in liver transplant recipients with cirrhosis. Sixty patients with end-stage liver disease underwent 62 consecutive orthotopic liver transplants between October 1988 and January 1991. The total and intraoperative requirements of red cells, platelets and fresh frozen plasma (FFP) were analysed for three groups of liver transplant recipients, those without cirrhosis (n = 15), those with cirrhosis (n = 25) and those with cirrhosis who received intraoperative aprotinin (n = 20). Fifteen without cirrhosis had mean total requirements of 15 units of red cells, 18 units of platelets and 16 units of FFP. Twenty patients with cirrhosis who received intraoperative aprotinin had broadly similar requirements. However, blood product requirements for 25 patients with cirrhosis were significantly greater (46 units of red cells, 41 units of platelets, 43 units of FFP, excluding the seven patients with primary biliary cirrhosis). We conclude that a liver transplant programme can be supported by a teaching hospital blood bank. The use of intraoperative aprotinin significantly reduces blood product requirements.
authors.affiliation: Department of Haematology, Royal Free Hospital and School of Medicine, London, U.K.
authors.forename: O
authors.initials: O
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Hazlehurst
authors.forename: B
authors.initials: B
authors.lastname: Brozovic
authors.forename: K
authors.initials: K
authors.lastname: Rolles
authors.forename: A
authors.initials: A
authors.lastname: Burroughs
authors.forename: S
authors.initials: S
authors.lastname: Mallett
authors.forename: K
authors.initials: K
authors.lastname: Dawson
authors.forename: A
authors.initials: A
authors.lastname: Mehta
mesh_terms: D000328:Adult; D007611:Aprotinin / Q000494:pharmacology*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology; D016913:Blood Component Transfusion / Q000706:statistics & numerical data; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002648:Child; D004341:Drug Evaluation; D017707:Erythrocyte Transfusion; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007430:Intraoperative Care; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000601:surgery*; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010949:Plasma; D017713:Platelet Transfusion; D012189:Retrospective Studies
chemical_list: D007611:Aprotinin