title: A retrospective comparative study evaluating the results of mild hyperthermic versus controlled normothermic perfusion for recurrent melanoma of the extremities.
abstract: The aim of this study was to investigate the role of mild hyperthermia (39-40 degrees C) in isolated cytostatic perfusion for patients with recurrent melanoma of the extremities. A total of 218 patients treated with mild hyperthermic perfusion was compared to 166 patients perfused under controlled normothermic conditions (37-38 degrees C). Only patients whose lesions had been excised before or at the moment of perfusion were eligible for this study. A variety of prognostic factors was controlled for in a Cox proportional hazards analysis. The application of mild hyperthermia did not influence limb recurrence-free interval nor survival (corrected P values 0.46 and 0.18, respectively). In this retrospective comparative study, no benefit for mild hyperthermia in regional isolated perfusion could be identified.
authors.affiliation: Department of Surgery, The Netherlands Cancer Institute, Amsterdam.
authors.forename: J M
authors.initials: JM
authors.lastname: Klaase
authors.forename: B B
authors.initials: BB
authors.lastname: Kroon
authors.forename: A M
authors.initials: AM
authors.lastname: Eggermont
authors.forename: A N
authors.initials: AN
authors.lastname: van Geel
authors.forename: H
authors.initials: H
authors.lastname: Schraffordt Koops
authors.forename: J
authors.initials: J
authors.lastname: Oldhoff
authors.forename: D
authors.initials: D
authors.lastname: Liénard
authors.forename: F J
authors.initials: FJ
authors.lastname: Lejeune
authors.forename: R
authors.initials: R
authors.lastname: Berkel
authors.forename: H R
authors.initials: HR
authors.lastname: Franklin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D008558:Melphalan