[Effect of MESNA on intracellular accumulation of doxorubicin and its interaction with DNA].
The effect of MESNA, an uroprotector (sodium 2-mercaptoethane sulfonate) on intracellular accumulation of doxorubicin and its interaction with DNA was studied in the cultures of the cells of human ovary carcinoma (CaOV) and normal epithelial kidney cells of green monkeys (VERO). The study was performed with methods developed by the authors. The results showed that MESNA had no effect on the qualitative and quantitative characteristics of the indicated processes in both the types of the doxorubicin sensitive cells. It was concluded that with the combined use of doxorubicin and phosphamide or cyclophosphane the use of MESNA for lowering the urotoxic action of oxazophosphorines had no effect on the biological efficacy of doxorubicin. The necessity of studying the possible modifying effect of MESNA in the cultures of doxorubicin resistant cells and in vivo is indicated.
Bogush
T A
TA
Smirnova
G B
GB
Chmutin
E F
EF
Shubina
I Zh
IZh
Ivanova
T P
TP
D000818:Animals; D002522:Chlorocebus aethiops; D004247:DNA / Q000378:metabolism*; D003630:Daunorubicin / Q000378:metabolism*; D006801:Humans; D015080:Mesna / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D004247:DNA; D015080:Mesna; D003630:Daunorubicin