title: Randomized controlled study of chemoprophylaxis in transurethral prostatectomy.
abstract: We studied 599 evaluable patients with benign prostatic hypertrophy at 7 urological units. Before transurethral prostatectomy the patients were randomized into 3 groups: group 1--197 patients given single-dose ceftriaxone (2 gm.), group 2--203 patients given 160/800 mg. trimethoprimsulfamethoxazole and group 3--199 controls given no antimicrobial prophylaxis. Patients with a preoperative indwelling catheter, positive urine culture, signs of active infection or preoperative antibiotic treatment were excluded. Postoperative infectious complications were demonstrated in 15 of 197 (7.6%), 25 of 203 (12.3%) and 43 of 199 (21.6%) patients in the study groups, respectively. The difference in infectious complications between groups 1 and 3 was statistically highly significant (p < 0.01) and between groups 2 and 3 it was significant (p < 0.05). Single-dose antibiotic prophylaxis proved to be useful in the prevention of serious infectious complications after transurethral prostatectomy.
authors.affiliation: North Karelian Central Hospital, Joensuu, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Viitanen
authors.forename: M
authors.initials: M
authors.lastname: Talja
authors.forename: E
authors.initials: E
authors.lastname: Jussila
authors.forename: M
authors.initials: M
authors.lastname: Nurmi
authors.forename: J
authors.initials: J
authors.lastname: Permi
authors.forename: V M
authors.initials: VM
authors.lastname: Puolakka
authors.forename: E
authors.initials: E
authors.lastname: Rintala
authors.forename: H
authors.initials: H
authors.lastname: Salmela
authors.forename: J
authors.initials: J
authors.lastname: Tiitinen
authors.forename: K
authors.initials: K
authors.lastname: Tuhkanen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000517:prevention & control*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000601:surgery*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002443:Ceftriaxone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination