Preoperative chemotherapy for mesoblastic nephroma.
A neonate with extensive stage III mesoblastic nephroma was confirmed at operation to have a tumor that was too infiltrative and too advanced for primary excision. The abdomen was closed after multiple biopsies. Vincristine (1.1 mg/m2) was given intravenously once a week for a total of eight doses. Repeat CT scan confirmed shrinkage of the tumor and a nephrectomy could be performed safely and the tumor removed at the second laparotomy. CT scan repeated 1 year later showed no recurrence. This case illustrates the effective use of a single drug pre-excision chemotherapy which allowed a nephrectomy for extensive stage III mesoblastic nephroma to be carried out safely.
Chan
K L
KL
Department of Surgery, University of Hong Kong, Queen Mary Hospital.
Chan
K W
KW
Lee
C W
CW
Saing
H
H
D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000151:congenital / Q000188:drug therapy* / Q000601:surgery; D009392:Nephrectomy; D018201:Nephroma, Mesoblastic / Q000151:congenital / Q000188:drug therapy* / Q000601:surgery