title: [Effectiveness of treatment of experimental glanders after aerogenic infection].
abstract: The in vitro studies revealed a number of promising drugs including gentamicin, doxycycline and minocycline for the treatment of malleus. The malleus causative agent was found to be highly susceptible to sulfamonomethoxine and biseptol as well as to imipenem and ofloxacin. Cephalosporins were less active but in the therapeutic concentrations they inhibited the growth of Pseudomonas mallei. In the treatment of golden hamsters infected subcutaneously by P. mallei ofloxacin proved to be the most active drug, then followed biseptol, doxycycline and minocycline. None of the tested drugs cured the animals infected aerogenically by 160 LD50 of P. malleus. When the infective dose was lower (16 LD50) only doxycycline provided a 70-percent protection of the animals.
authors.forename: V I
authors.initials: VI
authors.lastname: Iliukhin
authors.forename: V V
authors.initials: VV
authors.lastname: Alekseev
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Antonov
authors.forename: S T
authors.initials: ST
authors.lastname: Savchenko
authors.forename: N A
authors.initials: NA
authors.lastname: Lozovaia
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use; D006224:Cricetinae; D004318:Doxycycline / Q000627:therapeutic use; D005839:Gentamicins / Q000627:therapeutic use; D005896:Glanders / Q000188:drug therapy*; D015378:Imipenem / Q000627:therapeutic use; D008647:Mesocricetus; D008911:Minocycline / Q000627:therapeutic use; D015242:Ofloxacin / Q000627:therapeutic use; D013422:Sulfamonomethoxine / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D015378:Imipenem; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015242:Ofloxacin; D008911:Minocycline; D004318:Doxycycline; D013422:Sulfamonomethoxine