Importance of interleukin-3 on histamine release from human basophils.
We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P < .0001).
Sugiyama
H
H
Allergic Disease Center, Creighton University School of Medicine, Omaha, Nebraska.
Eda
R
R
Hopp
R J
RJ
Bewtra
A K
AK
Townley
R G
RG
D000328:Adult; D001249:Asthma / Q000097:blood; D001491:Basophils / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000494:pharmacology; D007377:Interleukin-3 / Q000494:pharmacology*; D008297:Male
D007377:Interleukin-3; D007073:Immunoglobulin E