Pharmacodynamic interactions of omeprazole with CNS active drugs in rats.
A pharmacodynamic interactional study with omeprazole was undertaken in rats. Omeprazole (7 mg/kg, orally once daily for 14 days) significantly prolonged pentobarbitone (30 mg/kg, ip) induced hypnosis while it had no effect on haloperidol (1 mg/kg, ip) induced catalepsy or morphine (5 mg/kg, ip) induced analgesia models in rats. The study highlighted the fact that dynamic interaction with omeprazole was selective.
Chandrashekhar
S M
SM
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh.
Chakrabarti
A
A
Garg
S K
SK
D000284:Administration, Oral; D000698:Analgesia; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D006990:Hypnosis; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009853:Omeprazole / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats
D009020:Morphine; D010424:Pentobarbital; D006220:Haloperidol; D009853:Omeprazole