title: Controlled ovarian hyperstimulation with or without intrauterine insemination for the treatment of unexplained infertility.
abstract: OBJECTIVE
  To evaluate whether there are any benefits from intrauterine insemination (IUI) as opposed to timed intercourse (TI) in stimulated ovarian cycles in couples with longstanding, unexplained infertility.
  
  
  METHODS
  Forty-six couples with diagnoses of unexplained infertility were evaluated in a crossover study after a total of 141 cycles. Sixty-seven cycles were with IUI after controlled ovarian hyperstimulation (COH) while 74 cycles were after COH and TI.
  
  
  RESULTS
  The pregnancy rate after COH/TI was 16.7% and after COH/IUI 45.2%. Cycle fecundity however was 8.9% after COH/TI and 25.7% after COH/IUI, which is a statistically significant difference (P < 0.05).
  
  
  CONCLUSIONS
  A trial of human menopausal gonadotropin and IUI is justified in couples with prolonged infertility of unknown cause.
authors.affiliation: 2nd Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
authors.forename: O
authors.initials: O
authors.lastname: Gregoriou
authors.forename: N
authors.initials: N
authors.lastname: Vitoratos
authors.forename: C
authors.initials: C
authors.lastname: Papadias
authors.forename: S
authors.initials: S
authors.lastname: Konidaris
authors.forename: A
authors.initials: A
authors.lastname: Gargaropoulos
authors.forename: C
authors.initials: C
authors.lastname: Louridas
mesh_terms: D000328:Adult; D003075:Coitus; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007246:Infertility / Q000628:therapy*; D007317:Insemination, Artificial, Homologous; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D008596:Menotropins