Recombinant human granulocyte colony-stimulating factor therapy for cyclic neutropenia associated with common variable immunodeficiency.
A 14 year old boy with common variable immunodeficiency (CVID) had regularly recurring episodes of severe infections independently of the serum gamma-globulin level. Serial blood counts revealed that this patient also had cyclic neutropenia. Recently, recombinant human granulocyte colony-stimulating factor (rhG-CSF) was reported to be an effective treatment for this disease. We tried rhG-CSF therapy for this patient and a prompt increase in the neutrophil count was noted. However, the cyclic alterations and duration of the nadir of the neutrophil count were not altered, which suggested that rhG-CSF has a variable efficacy in at least some patients with cyclic neutropenia.
Tsuda
M
M
Department of Pediatrics, Nihon University, School of Medicine, Tokyo, Japan.
Urakami
T
T
Watanabe
S
S
Shimizu
H
H
Inana
I
I
Kikkawa
Y
Y
Kitagawa
T
T
D000293:Adolescent; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000150:complications*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007239:Infections / Q000209:etiology*; D007279:Injections, Subcutaneous; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000209:etiology / Q000628:therapy*; D009504:Neutrophils; D010507:Periodicity; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence
D016756:Immunoglobulins, Intravenous; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor