Mivacurium-induced prolonged neuromuscular block.
We report a case of prolonged neuromuscular block after administration of mivacurium 0.2 mg kg-1 to a 16-yr-old patient where the duration of block was 2.5 h. The interesting points in this case were that the patient had homozygous atypical plasma cholinesterase deficiency (both parents had a normal phenotype) following liver transplantation. Investigations showed low plasma cholinesterase activity (343 iu litre-1; normal 600-1400) and dibucaine number was 25 (normal 76-83). Despite possessing atypical enzyme normally associated with markedly prolonged duration of suxamethonium, on two occasions the patient received suxamethonium and responded normally. This had not previously been reported. The patient demonstrated prolonged block with mivacurium as a result of atypical enzyme (despite normal metabolism of suxamethonium).
Sockalingam
I
I
Department of Anaesthesia, King's College Hospital, Denmark Hill, London.
Green
D W
DW
D000293:Adolescent; D000762:Anesthesia Recovery Period; D002802:Cholinesterases / Q000172:deficiency; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism*; D016031:Liver Transplantation; D000077590:Mivacurium; D009407:Nerve Block; D009469:Neuromuscular Junction / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000378:metabolism*; D011183:Postoperative Complications; D013390:Succinylcholine / Q000378:metabolism; D013997:Time Factors
D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002802:Cholinesterases; D013390:Succinylcholine