title: Iridium-192 high dose rate brachytherapy combined with external beam irradiation in non-resectable oesophageal cancer.
abstract: Forty-eight patients with non-resectable cancer of the oesophagus and oesophagogastric junction (group A: Stage I/II: n = 32; group B: Stage III/IV: n = 16) underwent intralumenal iridium-192 high dose-rate afterloading brachytherapy (5-7 Gy/session, total dose 5-21 Gy, mean 12.4 Gy) and external beam irradiation (Karnofsky > or = 80%: 50-60 Gy/2 Gy per day; Karnofsky 60%-79%: 30 Gy/3 per day). Prolonged satisfactory palliation (intake of at least semi-solid food) was demonstrated in 96% of patients. The mean survival for group A was 19.1 months and that for group B 6.9 months, with a 12-month survival rate of 66% for group A and 0% for group B (P < 0.001). Local tumour response and complication rate were significantly dose related with a predicted response rate of 70.5% and a complication rate of 50% at extrapolated response dose (ERD) 129.3 GY3 (Gy at alpha/beta = 3).
authors.affiliation: Department of Radiotherapy, University of Graz, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Pakisch
authors.forename: P
authors.initials: P
authors.lastname: Kohek
authors.forename: E
authors.initials: E
authors.lastname: Poier
authors.forename: G
authors.initials: G
authors.lastname: Stücklschweiger
authors.forename: J
authors.initials: J
authors.lastname: Poschauko
authors.forename: J
authors.initials: J
authors.lastname: Raith
authors.forename: F
authors.initials: F
authors.lastname: Quehenberger
authors.forename: R
authors.initials: R
authors.lastname: Mayer
authors.forename: A
authors.initials: A
authors.lastname: Hackl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects; D004938:Esophageal Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011879:Radiotherapy Dosage; D015996:Survival Rate
chemical_list: D007496:Iridium Radioisotopes