title: Spatial differences of the duration of ventricular late fields in the signal-averaged magnetocardiogram in patients with ventricular late potentials.
abstract: Magnetocardiography (MCG) allows one to noninvasively localize cardiac electrical activity in three dimensions. It was the purpose of this study to obtain information about the spatial variations of signal-averaged ventricular late magnetic fields recorded by a biomagnetic multichannel system. Biomagnetic signals of 170-600 heart cycles obtained by the 37-channel system KRENIKON (Siemens Medical Engineering Group) were simultaneously averaged in all channels. The absolute values of the filtered signals (digital, bidirectional, four-pole butterworth, bandpass filter [3-dB range, 40-250 Hz]) were calculated in each channel. The noise level was determined within the TP segment. The onset of the terminal low amplitude signals (TLAS) was defined when the signals became lower than 1/23 of Rmax of the QRS complex for the channel with the largest filtered QRS complex after filtering. The TLAS ended when the signal was lower than twice the standard deviation (2 sigma) above the mean noise level. Ventricular late fields were defined as present when the TLAS had a duration of more than 39 msec. In this study, five patients with ventricular late potentials (four with sustained ventricular tachycardia) and three healthy individuals were examined. Ventricular late fields were detected in the patient group in 2-15 MCG channels with a mean length of 49.6 msec (43-60 msec). The spatial distribution of the ventricular late fields was consistently found to exhibit maximum duration in a certain area. In the normal subjects no ventricular late fields were detected. Thus, MCG is able to detect ventricular late fields and their spatial variations. In addition to the information obtained by signal averaging from the surface ECG, averaging of biomagnetic signals with a multichannel device can reveal spatial inhomogeneity of delayed myocardial excitation.
authors.affiliation: Department of Cardiology, Angiology, and Pneumology, University of Ulm, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Weismüller
authors.forename: P
authors.initials: P
authors.lastname: Richter
authors.forename: K
authors.initials: K
authors.lastname: Abraham-Fuchs
authors.forename: W
authors.initials: W
authors.lastname: Härer
authors.forename: S
authors.initials: S
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Höher
authors.forename: M
authors.initials: M
authors.lastname: Kochs
authors.forename: J
authors.initials: J
authors.lastname: Edrich
authors.forename: V
authors.initials: V
authors.lastname: Hombach
mesh_terms: D004562:Electrocardiography / Q000379:methods*; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008280:Magnetics; D009203:Myocardial Infarction / Q000150:complications; D012815:Signal Processing, Computer-Assisted; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000209:etiology