Amiprilose hydrochloride inhibits porcine aortic smooth muscle cell proliferation in vitro.
The effect of amiprilose hydrochloride, a synthetic monosaccharide, on smooth muscle cell proliferation was studied in vitro. Using porcine aortic smooth muscle cell cultures, amiprilose significantly inhibited cell proliferation in a dose-dependent fashion at concentrations of 0.5-1.0 mg/ml. This antiproliferative effect was reversible upon removing amiprilose by cell washing and adding fresh media. Pretreating cells with amiprilose before serum stimulation did not affect subsequent growth. Inhibition of proliferation occurred when amiprilose was added up to 48 hours after serum stimulation. As such, amiprilose deserves further investigation as a potential therapeutic agent in preventing restenosis after angioplasty.
Siegel
C O
CO
Methodist Hospital, Houston, TX.
Churchill
D A
DA
Vu
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L
Guyton
J R
JR
Minor
S T
ST
Raizner
A E
AE
D000818:Animals; D001011:Aorta; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006131:Growth Inhibitors / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D012266:Ribose / Q000031:analogs & derivatives; D013552:Swine
D006131:Growth Inhibitors; D012266:Ribose; D005944:Glucosamine; C018424:amiprilose