Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.
Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.
Whitworth
C E
CE
Department of Pathology, University of Edinburgh, Scotland, United Kingdom.
Fleming
S
S
Cumming
A D
AD
Morton
J J
JJ
Burns
N J
NJ
Williams
B C
BC
Mullins
J J
JJ
D000818:Animals; D030801:Animals, Genetically Modified; D001794:Blood Pressure / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D006579:Heterozygote; D006801:Humans; D006974:Hypertension, Malignant / Q000209:etiology* / Q000235:genetics* / Q000473:pathology; D007668:Kidney / Q000473:pathology; D008297:Male; D010641:Phenotype; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D012982:Sodium, Dietary / Q000008:administration & dosage
D012982:Sodium, Dietary