title: Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease.
abstract: Genetic factors related to the development of alcoholic liver and pancreatic diseases (ALD and APD) and of alcohol-induced asthma were analyzed. The development of ALD is genetically controlled and is directly associated with the polymorphisms of the genes of acetaldehyde (Ac-CHO) and ethanol-metabolizing enzymes, aldehyde dehydrogenase-2 (ALDH2) and cytochrome P4502E1. The development of ALD and APD may also be genetically linked with the induction of gamma-glutamyl transferase (GTT) by alcohol. Alcohol-induced asthma is related to the genotypes of ALDH2 and is caused by rapid elevation of blood Ac-CHO. ALDH1 plays a very important role in the oxidation of Ac-CHO in blood.
authors.affiliation: Division of Gastroenterology, Kanazawi Medical University, Ishikawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takada
authors.forename: M
authors.initials: M
authors.lastname: Tsutsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000079:Acetaldehyde / Q000097:blood; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D001249:Asthma / Q000201:enzymology / Q000235:genetics; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004790:Enzyme Induction / Q000235:genetics; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008108:Liver Diseases, Alcoholic / Q000201:enzymology / Q000235:genetics*; D008173:Lung Diseases, Obstructive / Q000201:enzymology / Q000235:genetics*; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000235:genetics
chemical_list: D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D000444:Aldehyde Dehydrogenase; D010089:Oxidoreductases, N-Demethylating; D005723:gamma-Glutamyltransferase; D000079:Acetaldehyde