A novel bioactive delta lactone FD-211. Taxonomy, isolation and characterization.
During our screening program for natural product drugs effective against multidrug-resistant mammalian cells, we have discovered a new delta lactone FD-211 from the fermantation broth of Myceliophthora lutea TF-0409. FD-211 had a broad spectrum activity against cultured tumor cell lines, including adriamycin-resistant HL-60 cells.
Nozawa
O
O
Department of Applied Biology, Research Center of Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Okazaki
T
T
Sakai
N
N
Komurasaki
T
T
Hanada
K
K
Morimoto
S
S
Chen
Z X
ZX
He
B M
BM
Mizoue
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008855:Microscopy, Electron, Scanning; D003904:Mitosporic Fungi / Q000378:metabolism / Q000648:ultrastructure; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; C092867:FD 211; D007783:Lactones