Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve.
OBJECTIVE
To characterize the constituents of corpora amylacea in the human retina and optic nerve.


METHODS
Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein.


RESULTS
Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein.


CONCLUSIONS
Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin.
Loeffler
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KU
Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
Edward
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DP
Tso
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MO
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016564:Amyloid beta-Protein Precursor; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology*; D008869:Microtubule-Associated Proteins; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology; D009900:Optic Nerve / Q000378:metabolism / Q000473:pathology*; D012160:Retina / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling
D016564:Amyloid beta-Protein Precursor; D008869:Microtubule-Associated Proteins