title: Effects of physical activity on creatine phosphokinase and the isoenzyme creatine kinase-MB.
abstract: Creatine phosphokinase (CPK) and creatine kinase-MB (CK-MB) have been used extensively as diagnostic markers for myocardial infarction and skeletal muscle injury. Many factors affect the variability of serum CPK and serum CK-MB activity, especially physical activity. We discuss the influence of physical activity on muscle and serum CPK and CK-MB. The effect of acute and chronic exercise on CPK and CK-MB activity emphasizes the need to use measurements of serum CPK and CK-MB with caution when evaluating and diagnosing acute myocardial infarctions and skeletal muscle injury.
authors.affiliation: Department of Kinesiology, University of Northern Colorado, Greeley.
authors.forename: C M
authors.initials: CM
authors.lastname: Schneider
authors.forename: C A
authors.initials: CA
authors.lastname: Dennehy
authors.forename: S J
authors.initials: SJ
authors.lastname: Rodearmel
authors.forename: J R
authors.initials: JR
authors.lastname: Hayward
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology*; D012727:Sex Characteristics
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase