Recurrence of primary biliary cirrhosis after liver transplantation following FK506-based immunosuppression.
We report two cases of recurrence of primary biliary cirrhosis (PBC) in the transplanted liver whilst maintained on a FK506-based immunosuppressive regime, the first to be described. One patient experienced symptoms in association with the development of cholestasis. In both there was a persistence of serological markers of PBC and liver histology revealed florid bile duct destruction and a granulomatous reaction.
Wong
P Y
PY
Institute of Liver Studies, King's College Hospital and School of Medicine and Dentistry, London, United Kingdom.
Portmann
B
B
O'Grady
J G
JG
Devlin
J J
JJ
Hegarty
J E
JE
Tan
K C
KC
Williams
R
R
D000328:Adult; D002779:Cholestasis / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000209:etiology* / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016559:Tacrolimus / Q000627:therapeutic use*
D016559:Tacrolimus