title: Olfactory neuroblastoma: clinical and pathological aspects.
abstract: Twenty cases of olfactory neuroblastoma were available for clinical and histopathological evaluation. The usefulness of immunohistochemistry in the diagnosis of this tumour was investigated and was best achieved using a panel of monoclonal and polyclonal antibodies, notably neuron-specific enolase, PGP 9.5, S-100 protein, synaptophysin and chromogranin A. This study confirmed that immunohistochemistry is a useful adjunct in cases where conventional histology is equivocal.
authors.affiliation: Institute of Laryngology and Otology, London, United Kingdom.
authors.forename: V J
authors.initials: VJ
authors.lastname: Lund
authors.forename: C
authors.initials: C
authors.lastname: Milroy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D053379:Chromogranin A; D002864:Chromogranins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology* / Q000648:ultrastructure; D009669:Nose Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase; D009418:S100 Proteins; D013194:Staining and Labeling; D016708:Synaptophysin; D013869:Thiolester Hydrolases; D016896:Treatment Outcome; D043222:Ubiquitin Thiolesterase
chemical_list: D000911:Antibodies, Monoclonal; D053379:Chromogranin A; D002864:Chromogranins; D009418:S100 Proteins; D016708:Synaptophysin; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D010751:Phosphopyruvate Hydratase