Effect of mebendazole on free amino acid composition of cyst wall and cyst fluid of Echinococcus granulosus harbored in mice.
Eighteen and 23 FAA components were detected in the cyst wall and cyst fluid of E granulosus, respectively, by using automatic amino acid analyzer. The concentrations of most of the determined FAA were higher in the cyst fluid than those in the cyst wall, especially the taurine was 5-fold higher. Mebendazole treatment resulted in an increase in the concentration of alanine, valine, lysine, and taurine in both cyst wall and cyst fluid, the most notable being the alanine in the cyst wall. The results are interpreted as a coupling of glycolysis and amino acid metabolism, suggesting an involvement of FAA metabolism in the mechanism of Meb action.
Yao
M Y
MY
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine.
Xiao
S H
SH
Feng
J J
JJ
Xue
C L
CL
Shimada
M
M
D000409:Alanine / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D004443:Echinococcosis / Q000378:metabolism; D004446:Echinococcus / Q000378:metabolism*; D005260:Female; D008463:Mebendazole / Q000494:pharmacology*; D051379:Mice
D000596:Amino Acids; D008463:Mebendazole; D000409:Alanine