title: Tissue ablation in benign prostatic hyperplasia with high-intensity focused ultrasound.
abstract: The safety and effectiveness of tissue ablation by coagulative necrosis with high-intensity focused ultrasound (HIFU) applied through a rectal probe to 36 patients with symptomatic benign prostatic hyperplasia (BPH) was investigated in a phase II clinical trial. Overall, HIFU treatment was well tolerated, the mean hospital stay being 1.1 days. Negative side effects were transient urinary retention in 32/36 patients, hematuria in 2 patients and hematospermia resolving after 3-4 weeks (n = 15). After 3 months the maximum flow rate/s (Qmax) increased from 9.0 +/- 3.9 to 14.4 +/- 7.0 ml/s, the median flow rate/s (QM90) from 4.9 +/- 2.4 to 7.6 +/- 4.17 ml/s; the postvoid residual volume decreased from 128 +/- 88 to 57 +/- 35 ml and the AUA symptom score from 25.5 +/- 5 to 13.2 +/- 4.4. In conclusion, it was shown that tissue ablation in patients with symptomatic BPH using HIFU is safe and dramatically reduces both obstructive and irritative symptoms and leads to a significant increase in uroflow and a decrease in postvoid residual volume.
authors.affiliation: Department of Urology, University of Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Madersbacher
authors.forename: C
authors.initials: C
authors.lastname: Kratzik
authors.forename: N
authors.initials: N
authors.lastname: Szabo
authors.forename: M
authors.initials: M
authors.lastname: Susani
authors.forename: L
authors.initials: L
authors.lastname: Vingers
authors.forename: M
authors.initials: M
authors.lastname: Marberger
mesh_terms: D005240:Feasibility Studies; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D009336:Necrosis; D011470:Prostatic Hyperplasia / Q000473:pathology / Q000628:therapy*; D014464:Ultrasonic Therapy / Q000009:adverse effects / Q000379:methods