title: The mutator mut7-1 of Saccharomyces cerevisiae.
abstract: The mut7-1 mutant of Saccharomyces cerevisiae is a cell-division-cycle mutant, exhibiting temperature-sensitive lethality and enhancement of mutator activity with increases in temperature. The base-sequence alterations in mutants arising in a mut7-1 background differed from the control by there being a higher transversion/transition ratio and by the much increased production of multi-base deletions. The deletions were, in every instance, associated with repeated oligonucleotide sequences (3-8 bases in length), where one of the two sequences was removed during the deletion process. The mutant mut7-1 failed to complement with cdc2, the temperature-sensitive mutant of the locus which encodes DNA polymerase III (delta).
authors.affiliation: Department of Genetics, University of Alberta, Edmonton, Canada.
authors.forename: R C
authors.initials: RC
authors.lastname: von Borstel
authors.forename: R W
authors.initials: RW
authors.lastname: Ord
authors.forename: S P
authors.initials: SP
authors.lastname: Stewart
authors.forename: R G
authors.initials: RG
authors.lastname: Ritzel
authors.forename: G S
authors.initials: GS
authors.lastname: Lee
authors.forename: U G
authors.initials: UG
authors.lastname: Hennig
authors.forename: E A
authors.initials: EA
authors.lastname: Savage
mesh_terms: D001483:Base Sequence; D002455:Cell Division; D005784:Gene Amplification; D005838:Genotype; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013696:Temperature