Effects of repeated cocaine injections on cochlear function.
The effects of repeated cocaine administration on cochlear function were evaluated by measuring amplitude-intensity and latency-intensity functions of the whole-nerve action potential of the auditory nerve. Whole-nerve action potential input/output functions obtained using tone-pips of 0.5, 1, 2, 4 and 8 kHz in a group of cocaine-treated subjects were compared with those obtained in saline-treated animals. All measurements were made 24 h after the last treatment. Amplitudes of whole-nerve action potentials were enhanced in the cocaine-treated animals compared to the control group. No statistically significant differences in latency-intensity functions were seen after cocaine treatment. The effect of chronic cocaine exposure also was examined on catecholamine innervation in the cochlea using immunohistochemical techniques. The density of adrenergic innervation was reduced in the cocaine-treated animals.
Shivapuja
B G
BG
Department of Otolaryngology, Henry Ford Hospital, Detroit, MI 48202, USA.
Gu
Z P
ZP
Liu
S Y
SY
Saunders
S S
SS
Schoener
E P
EP
D000161:Acoustic Stimulation; D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D002682:Chinchilla; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003051:Cochlea / Q000098:blood supply / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004299:Dopamine beta-Hydroxylase / Q000032:analysis; D004334:Drug Administration Schedule; D007150:Immunohistochemistry; D007649:Ketamine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D009925:Organ of Corti / Q000187:drug effects; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D007649:Ketamine; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D003042:Cocaine; D009638:Norepinephrine