title: The role of the central nervous system in sudden cardiac death: heartbeat dynamics in conscious pigs during coronary occlusion, psychologic stress and intracerebral propranolol.
abstract: Electrocardiograms were recorded in conscious pigs during psychological stress (touching), left anterior descending coronary artery occlusion, intracerebral levopropranolol (0.05 mg/kg), and their respective controls. The R-R intervals were evaluated with both a deterministic measure (point correlation dimension) and a stochastic one (mean). Only the deterministic measure was sensitive to between-subject responses (P < .01), whereas both measures were sensitive to within-subject changes. The results are explained by a deterministic model of heartbeat generation.
authors.affiliation: Totts Gap Medical Research Laboratories, Bangor, PA 18013.
authors.forename: J E
authors.initials: JE
authors.lastname: Skinner
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000502:physiology*; D007276:Injections, Intraventricular; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013552:Swine
chemical_list: D011433:Propranolol