N-(indol-3-ylglyoxylyl)amino acid ester derivatives. Synthesis and interaction properties at the benzodiazepine receptor.
Several N-(indol-3-ylglyoxylyl)alanine and glycine ester derivatives were prepared to evaluate the influence of the ester group size both on affinity and on activity at the benzodiazepine receptor. Moreover, indol-3-ylglyoxylic acid esters, closely related to 3-alkoxy-beta-carbolines, were synthesized and tested in vitro on the benzodiazepine receptor.
Primofiore
G
G
Istituto Policattedra di Discipline Biologiche dell'Università di Pisa, Italy.
Da Settimo
F
F
Marini
A M
AM
La Motta
C
C
Martini
C
C
Senatore
G
G
Lucacchini
A
A
D000818:Animals; D002417:Cattle; D005445:Flunitrazepam / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis* / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism*; D013329:Structure-Activity Relationship
D007211:Indoles; D011963:Receptors, GABA-A; D005445:Flunitrazepam