Methods for detection of an intestinal secretory immunoglobulin A response to Candida spp. and their preliminary application in human immunodeficiency virus-infected patients with chronic diarrhea.
Six of 11 human immunodeficiency virus (HIV)-infected patients with chronic diarrhea, shedding only Candida spp. in their stools, elicited a Candida-specific secretory immunoglobulin A response. Similar responses were identified in only 1 of 10 HIV-positive patients with chronic diarrhea but without Candida spp. and in none of 10 HIV-negative subjects without diarrhea. Candida spp. may play a role in the etiology of chronic diarrhea associated with HIV infection.
Scerpella
E G
EG
Center for Infectious Diseases, University of Texas Medical School, Houston.
Gould
S S
SS
Mathewson
J J
JJ
DuPont
H L
HL
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology* / Q000382:microbiology; D000946:Antigens, Fungal; D015153:Blotting, Western; D002177:Candidiasis / Q000276:immunology* / Q000821:virology; D002908:Chronic Disease; D003967:Diarrhea / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D015658:HIV Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis* / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism*; D012967:Sodium Dodecyl Sulfate
D000946:Antigens, Fungal; D007071:Immunoglobulin A, Secretory; D012967:Sodium Dodecyl Sulfate