title: [Changes of cognitive and emotional processes during immunostimulatory treatment in subacute sclerosing panencephalitis].
abstract: In 35 cases of SSPE sensibilized neuropsychological testing was done before and after 6 months of immunostimulatory and virostatic treatment. Three groups of patients were studied. All groups received isoprinosine, one group was given additionally TFX-thymus extract Polfa, and another group received additionally Propionibacterium granulosum KP-45. A tendency for improvement of verbal function and emotional status was observed only in the group receiving isoprinosine with propionibacterium. In both remaining groups, receiving only isoprinosine or isoprinosine with TFX worsening was noted, particularly in the isoprinosine-only group. This was particularly evident in the visuospatial orientation. Prolongation of survival time in SSPE owing to specific treatment increases the need for psychoreactive and therapeutic influences for stimulation of cognitive processes.
authors.affiliation: Kliniki Diagnostyki i Terapii Chorób Układu Nerwowego, Instytutu Psychiatrii i Neurologii, Warszawie.
authors.forename: T
authors.initials: T
authors.lastname: Jakubowska
authors.forename: E
authors.initials: E
authors.lastname: Luczywek
authors.forename: W
authors.initials: W
authors.lastname: Sobczyk
authors.forename: E
authors.initials: E
authors.lastname: Piłkowska
mesh_terms: D000293:Adolescent; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007542:Inosine Pranobex / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology*; D009483:Neuropsychological Tests; D011424:Propionibacterium; D013028:Space Perception / Q000187:drug effects; D013344:Subacute Sclerosing Panencephalitis / Q000188:drug therapy / Q000523:psychology*; D013949:Thymus Extracts / Q000627:therapeutic use; D014705:Verbal Behavior; D014796:Visual Perception / Q000187:drug effects
chemical_list: D013949:Thymus Extracts; D007542:Inosine Pranobex