Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development.
The fra-2 gene is related to the proto-oncogene c-fos and encodes a member of the AP-1 transcription factor gene family. We have studied the expression of fra-2 during mouse embryonic development and compared it to the pattern of expression of other fos and jun family members. By in situ hybridization and immunohistochemical analysis we have shown fra-2 expression during late organogenesis. fra-2 transcripts are detected in several differentiating epithelia, developing cartilage and central nervous system. The pattern of fra-2 expression is distinct from that observed for other fos related genes, suggesting that fra-2 has a unique role in cellular differentiation during fetal development.
Carrasco
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Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
Bravo
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D000311:Adrenal Glands / Q000196:embryology / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D001842:Bone and Bones / Q000196:embryology / Q000378:metabolism; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics*; D005314:Embryonic and Fetal Development / Q000235:genetics; D051921:Fos-Related Antigen-2; D018507:Gene Expression Regulation, Developmental; D016758:Genes, jun; D007150:Immunohistochemistry; D007668:Kidney / Q000196:embryology / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics*
D017931:DNA Primers; D004268:DNA-Binding Proteins; D051921:Fos-Related Antigen-2; C497873:Fosl2 protein, mouse; D016760:Proto-Oncogene Proteins c-fos; D014157:Transcription Factors