title: Annular granulomatous lesions in exogenous ochronosis are manifestation of sarcoidosis.
abstract: Annular lesions with histological changes that include a sarcoidal granulomatous reaction have been observed within hydroquinone-induced ochronotic changes in some patients. The clinical and histological similarity of these lesions to actinic granuloma has been reported previously. We describe six patients with annular granulomatous lesions located within the ochronotic areas. Three of them had evidence of systemic sarcoidosis. A comparison of the histological features of the annular lesions of this group with those of the three patients with only cutaneous sarcoidal changes showed only insignificant quantitative differences. We conclude that annular granulomatous lesions in patients with exogenous ochronosis is a form of sarcoidosis.
authors.affiliation: Department of Dermatology, University of Pretoria, Republic of South Africa.
authors.forename: W K
authors.initials: WK
authors.lastname: Jacyk
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen; D003937:Diagnosis, Differential; D004547:Elastic Tissue / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D005148:Facial Dermatoses / Q000139:chemically induced / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000473:pathology; D016460:Granuloma Annulare / Q000473:pathology*; D006801:Humans; D006873:Hydroquinones / Q000009:adverse effects; D017496:Hypopigmentation / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008875:Middle Aged; D009336:Necrosis; D009794:Ochronosis / Q000139:chemically induced / Q000473:pathology*; D012507:Sarcoidosis / Q000175:diagnosis* / Q000473:pathology
chemical_list: D006873:Hydroquinones; D003094:Collagen; C031927:hydroquinone