Self limited dermal invasion of keratinocytes in maculopapular eruptions after systemic chemotherapy.
Benign, multifocal, and transient (spontaneously disappearing within one month) stromal invasions of atypical basal keratinocytes were found in light and electron microscopic examination of maculopapular eruptions which developed after receiving an 8 day cycle of doxorubicin, 5-fluorouracil (5-FU), and cyclophosphamide (Cy) in a 63-year-old woman. She had had a modified radical mastectomy to remove a carcinoma of her right breast.
Hann
S K
SK
Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
Rhoe
B S
BS
Kang
W H
WH
Park
Y K
YK
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001485:Basement Membrane / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006818:Hyalin; D015603:Keratinocytes / Q000473:pathology*; D007633:Keratins; D008875:Middle Aged; D012867:Skin / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000473:pathology
C001500:keratohyalin; D007633:Keratins; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil