Nitric oxide synthesis and action in an invertebrate brain.
Nitric oxide (NO) is synthesized in mammalian neurons by Ca2+/calmodulin activated NO synthase and functions as a signalling molecule by activating soluble guanylyl cyclases in target cells. We demonstrate here that both NO synthase and NO-activated guanylyl cyclase are present in the brain of the locust Schistocerca gregaria. Our observations indicate, for the first time, that the NO-cyclic GMP signalling pathway exists in invertebrate nervous systems.
Elphick
M R
MR
Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton UK.
Green
I C
IC
O'Shea
M
M
D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006110:Grasshoppers / Q000378:metabolism*; D007700:Kinetics; D009474:Neurons / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase; D015398:Signal Transduction
D009569:Nitric Oxide; D000242:Cyclic AMP; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D006152:Cyclic GMP