title: Electrophilic 18F from a Siemens 11 MeV proton-only cyclotron.
abstract: Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [18O]O2. A method for the routine production of clinically useful quantities of [18F]F2 having a specific activity of 35 Ci/mmol has been developed and implemented using an 11 MeV proton cyclotron and [18O]O2. Based on the yield, purity, reproducibility, and specific activity of [18F]F2 this is the most efficient method reported thus far.
authors.affiliation: Department of Nuclear Medicine, Chedoke-McMaster Hospitals, Hamilton, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Chirakal
authors.forename: R M
authors.initials: RM
authors.lastname: Adams
authors.forename: G
authors.initials: G
authors.lastname: Firnau
authors.forename: G J
authors.initials: GJ
authors.lastname: Schrobilgen
authors.forename: G
authors.initials: G
authors.lastname: Coates
authors.forename: E S
authors.initials: ES
authors.lastname: Garnett
mesh_terms: D017357:Cyclotrons; D005462:Fluorine Radioisotopes
chemical_list: D005462:Fluorine Radioisotopes