Failure of thyroid allografts to function in the testes of cynomolgous monkeys.
Allografts of thyroid were placed into one testis of 8 cynomolgous monkeys. None of these had accumulated significant amounts of radioactive iodide 28 days later, whereas autografts of thyroid placed in the other testis of 6 of these monkeys did so in 5 cases out of the 6. Autografts of thyroid placed subcutaneously in these 6 monkeys also accumulated iodide in the same 5 animals, but subcutaneous allografts failed in all 6 monkeys in which these were done. These results suggest that there is no immune privilege for grafts in the primate testis, which in this regard resembles more the testis of the ram, rather than that of rodents.
Setchell
B P
BP
Pediatric Endocrinology Unit, Karolinska Hospital, Stockholm, Sweden.
Granholm
T
T
Ritzén
E M
EM
D000818:Animals; D006085:Graft Survival; D008252:Macaca fascicularis; D008297:Male; D013737:Testis; D013961:Thyroid Gland / Q000637:transplantation*; D016042:Transplantation, Heterotopic / Q000276:immunology*; D014184:Transplantation, Homologous