title: An evaluation of chemotherapy in patients with cancer of the cervix and lymph node metastases.
abstract: During the past twelve years, out of the 288 cervical cancer patients who had lymph node involvement, the recurrence rate in the lymph node, was 26.6% if one or two nodes were involved and 50.8% if three or more nodes were involved (P < 0.0001). The recurrence rate of patients who received eight intravenous treatments (at monthly intervals) of multi-agent chemotherapy was lower than those who did not receive treatment. Of patients with one or two positive lymph nodes, 114 received treatment while 50 did not; their respective recurrence rates were 19.3% and 42.0%, a statistically significant difference (P < 0.025). Of patients with three or more positive lymph nodes, 97 received treatment and 27 did not, their respective recurrence rates, were 46% and 66% (P = 0.30) and the difference is not statistically significant. It would seem that multi-agent chemotherapy may reduce the recurrence rate in patients with cancer of the cervix and positive lymph nodes.
authors.affiliation: Department of Obstetrics & Gynecology, National Yang-Ming Medical College, Veterans General Hospital, Taiwan, Republic of China.
authors.forename: H T
authors.initials: HT
authors.lastname: Ng
authors.forename: C C
authors.initials: CC
authors.lastname: Yuan
authors.forename: Y Y
authors.initials: YY
authors.lastname: Kan
authors.forename: E S
authors.initials: ES
authors.lastname: Ho
authors.forename: M S
authors.initials: MS
authors.lastname: Yen
authors.forename: K C
authors.initials: KC
authors.lastname: Chao
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery