title: The effect of the perflubron emulsion Oxygent on the calibration characteristics of polarographic oxygen electrodes.
abstract: The perfluorocarbon emulsion Oxygent improves normal tissue oxygenation. A clinical trial is planned to evaluate this effect in tumors. Polarographic oxygen electrodes were calibrated in solutions of saline +/- perflubron to assess whether Oxygent influenced probe behavior. Calibrations were linear under both conditions. There were no major differences in estimated oxygen tensions.
authors.affiliation: Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, NC 27710, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Brizel
authors.forename: R
authors.initials: R
authors.lastname: Dodge
authors.forename: M W
authors.initials: MW
authors.lastname: Dewhirst
mesh_terms: D002138:Calibration; D004655:Emulsions; D005466:Fluorocarbons / Q000494:pharmacology*; D006801:Humans; D006842:Hydrocarbons, Brominated; D066298:In Vitro Techniques; D010100:Oxygen / Q000032:analysis; D011048:Polarography / Q000295:instrumentation*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
chemical_list: D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D011838:Radiation-Sensitizing Agents; C003072:perflubron; D010100:Oxygen