Time course of effects of tetraethoxysilane (TEOS) on the kidney and blood silicon concentration in mice.
To clarify the time course of toxicological effects of tetraethoxysaline [Si(OC2H5)4, TEOS] on the kidney and the relationship between blood silicon levels (Si-B) and the effects, 250 mg/kg or 500 mg/kg TEOS was intraperitoneally administered to ten 5-week-old male ICR mice (SPF grade) in each group, and morphological and functional changes of the kidney were assessed at 12 h, 24 h, 3 days and 2 weeks after administration of TEOS. Injury to tubular epithelial cells was observed in mice killed 12 and 24 h after administration, and its severity increased with increasing dosage. The mean values of blood urea nitrogen exhibited dose-related increase in mice sacrificed 24 h after the administration. The concentrations of Si-B increased in order of the administered doses of TEOS, and then decreased steadily. The results of Si-B were consistent with the concept that renal toxicity of TEOS is mediated by siliceous compounds. The kidney was recovering from injury 3 days after administration, and had developed tubulointerstitial nephritis, which could be regarded as repaired lesion of acute injury, by 2 weeks after administration.
Nakashima
H
H
Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan.
D000818:Animals; D001806:Blood Urea Nitrogen; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008854:Microscopy, Electron; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000401:mortality / Q000473:pathology; D012821:Silanes / Q000008:administration & dosage / Q000633:toxicity*; D012825:Silicon / Q000097:blood* / Q000378:metabolism; D013047:Specific Pathogen-Free Organisms
D012821:Silanes; C040733:tetraethoxysilane; D012825:Silicon