Local effects of different perfluorochemical agents.
OBJECTIVE
To clarify whether the prolonged presence of perfluorochemicals (PFC) in the vitreous cavity causes oxidative tissue damage and inflammatory response of the retina and, if so, what the process is.


METHODS
After three different perfluorochemicals [perfluorodecalin (C10F18), perfluorooctane (C8F18) and Fluosol-DA (corresponding to a 20% emulsion of 70% PFD and 30% perfluorotripropylamine, C9F21N)] had been in the vitreous cavity of rabbits for 2 weeks, lipid peroxide concentration and myeloperoxidase activity in the retina were determined.


RESULTS
Whereas only Fluosol-DA showed significant oxidative damage, the inflammatory activity was significantly increased in all groups.


CONCLUSIONS
The increased myeloperoxidase activity and the observed oxidative damage of the retina seem to be the effect of both perfluorochemical-loaded macrophages and inflammatory-induced lipid peroxidation.
Augustin
A J
AJ
Universitäts-Augenklinik, Bonn, Germany.
Spitznas
M
M
Koch
F H
FH
Böker
T
T
Lutz
J
J
D000818:Animals; D005260:Female; D005466:Fluorocarbons / Q000633:toxicity*; D008054:Lipid Peroxides / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D012173:Retinitis / Q000139:chemically induced; D014822:Vitreous Body
D005466:Fluorocarbons; D008054:Lipid Peroxides; C008805:perfluorodecalin; C073608:perfluorooctane; C050455:fluosol; D009195:Peroxidase