title: Relationship between plasma levels of type II phospholipase A2, PAF acetylhydrolase, endothelin-1, and thrombomodulin in patients with infected burns.
abstract: The relations between type II phospholipase A2 (PLA2) and PAF acetylhydrolase (PAFAH) levels and those of endothelin-1 (ET-1) and thrombomodulin (TM) were examined in samples containing the maximum amount of TNF-alpha detected over the clinical course for each patient with burn wound infection. The study included 23 patients with a total burn surface area of > 20%. Plasma levels of tumor necrosis factor-alpha (TNF-alpha), type II PLA2, PAFAH, TM, and ET-1 were 174.1 +/- 239.5 pg/ml, 229.5 +/- 190.8 ng/ml, 22.68 +/- 7.07 nmol/min per ml, 6.62 +/- 2.78 ng/ml, and 7.45 +/- 2.99 pg/ml, respectively. There were significant correlations between plasma levels of type II PLA2 and TM (r = 0.767, p < 0.0001), between PAFAH and TM (r = 0.542, p = 0.0076), between type II PLA2 and ET-1 (r = 0.688, p = 0.0003), and between PAFAH and ET-1 (r = 0.516, p = 0.0117). These results suggest that the increases in plasma type II PLA2 and PAFAH are related to vascular endothelial disorders in patients with infected burns.
authors.affiliation: Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takakuwa
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: H
authors.initials: H
authors.lastname: Nakae
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Inada
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Uchida
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000097:blood*; D002056:Burns / Q000097:blood* / Q000382:microbiology; D016232:Endothelins / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011863:Radioimmunoassay; D018180:Thrombomodulin / Q000032:analysis*
chemical_list: D016232:Endothelins; D018180:Thrombomodulin; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase