title: [Modern representations of multiple forms of cyclic nucleotide phosphodiesterases in mammalian tissues].
abstract: The literary data from the past 10-15 years concerning cyclic nucleotide phosphodiesterase from animal tissues have been reviewed. The major properties of multiple forms of the enzyme differing in the mode of regulation, substrate specificity, physico-chemical parameters and primary structure are compared. The possible physiological role of the main phosphodiesterase forms and ways of their pharmacological regulation are discussed.
authors.forename: M V
authors.initials: MV
authors.lastname: Medvedeva
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004789:Enzyme Activation; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D006152:Cyclic GMP
vernacular_title: Sovremennye predstavleniia o mnogoobrazii form fosfodiésterazy tsiklicheskikh nukleotidov v tkaniakh mlekopitaiushchikh.