Zymosan-induced arthritis in rats. II. Effects of anti-inflammatory drugs.
As zymosan-induced arthritis in rats combines dual activation of early prostaglandin-dependent processes (edema, fever, pain) and IL-1 related effects on cartilage metabolism, we compared the respective influences of indomethacin (IMT) and dexamethasone (DEX) on its course. Different parameters were assessed: knee swelling, febrile response, loss of activity, cartilage metabolism and histology. DEX improved all these parameters, while IMT exerted only light beneficial effects on fever and knee swelling without obvious beneficial influence on cartilage metabolism and histological lesions. These results suggest that anti-inflammatory activities of DEX and IMT are due to interferences with different pathways during zymosan-induced arthritis in rats.
Gegout
P
P
Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, Université Henri Poincaré Nancy I, Vandoeuvre les Nancy.
Gillet
P
P
Terlain
B
B
Netter
P
P
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy*; D002358:Cartilage, Articular / Q000737:chemistry; D003907:Dexamethasone / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D007213:Indomethacin / Q000494:pharmacology*; D007719:Knee Joint / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010329:Patella / Q000378:metabolism; D011509:Proteoglycans / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D015054:Zymosan
D011509:Proteoglycans; D003907:Dexamethasone; D015054:Zymosan; D007213:Indomethacin