Are histamine H1 receptors involved in ischaemia/reperfusion injury in rat heart?
During ischaemia, there was no apparent change in malondialdehyde (MDA) content in rat myocardium. However, reoxygenation resulted in a significant increase in MDA content. The changes evoked by ischaemia and reoxygenation were significantly attenuated by addition of fenistil (histamine H1 receptor antagonist). Enzymatic antioxidant systems were not significantly modified in the different periods of ischaemia and after 30 min of reoxygenation. It is suggested, that maintenance of an adequate endogenous antioxidant reserve during ischaemia may be important in recovery upon reoxygenation.
Dzierzkowska
J
J
Department of Pathophysiology, Medical Academy, Warsaw, Poland.
Witanowska
A
A
Wojtecka-Lukasik
E
E
Droń
T
T
Moutiris
J A
JA
Gujski
M
M
Poppe
P
P
Prejbisz
H H
HH
Gajewska
J
J
Gajewski
M
M
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D006329:Heart Conduction System / Q000187:drug effects; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D015428:Myocardial Reperfusion Injury / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D011969:Receptors, Histamine H1 / Q000502:physiology*
D000975:Antioxidants; D011969:Receptors, Histamine H1; D008315:Malondialdehyde