title: Paeciloquinones A, B, C, D, E and F: new potent inhibitors of protein tyrosine kinase produced by Paecilomyces carneus. II. Characterization and structure determination.
abstract: Paeciloquinones A to F and versiconol have been isolated as inhibitors of protein tyrosine kinases from the culture broth of the fungus Paecilomyces carneus P-177. The structures of the new anthraquinones were determined by spectroscopic methods, mainly 1H NMR and 13C NMR. The substitution pattern was established by investigation of the respective methylated derivatives.
authors.affiliation: Pharmaceutical Research Department, Ciba-Geigy Ltd., Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Fredenhagen
authors.forename: P
authors.initials: P
authors.lastname: Hug
authors.forename: H
authors.initials: H
authors.lastname: Sauter
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010143:Paecilomyces / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
chemical_list: D000880:Anthraquinones; C072370:versiconol; D011505:Protein-Tyrosine Kinases