[Pharmacology of glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes].
Follicle-enclosed Xenopus oocytes have endogenous glibenclamide-sensitive K+ channels that can be activated by K+ channel openers. Since the follicle-enclosed Xenopus oocytes can be easily voltage-clamped, the K+ channels are used as a model of the ATP/glibenclamide-sensitive K+ channels. So far, the effects of calmodulin antagonists, antiarrhythmics, anesthetics, antidepressants, histamine H1-receptor antagonists, imidazolines and several hormones on the K+ channels of the oocytes have been reported. The pharmacological data on the K+ channels obtained from the oocyte-system may contribute to our understanding of the regulatory mechanism and physiological role of the ATP/glibenclamide-sensitive K+ channels.
Sakuta
H
H
Surgeon of the 9th Division, Aomori, Japan.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D002147:Calmodulin / Q000037:antagonists & inhibitors; D005905:Glyburide / Q000378:metabolism*; D009865:Oocytes / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism* / Q000502:physiology; D013449:Sulfonamides / Q000494:pharmacology; D014981:Xenopus
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D002147:Calmodulin; D015221:Potassium Channels; D013449:Sulfonamides; C017967:W 7; D000255:Adenosine Triphosphate; D005905:Glyburide