Glucose oxidation and monoamine oxidase activity from the fibroblasts of schizophrenic patients and controls.
Fibroblasts have emerged as one of the best systems in which to study several genetically inherited diseases. Their use avoids the contaminating effects of medication and other environmental factors. Moreover, fibroblast cells cultured in vitro can express several biochemical parameters which are characteristic of neuronal cells. We have studied fibroblast MAO-A and glucose oxidation and platelet MAO-B from schizophrenic patients and control subjects. Fibroblasts from schizophrenics showed an increased glucose oxidation in two different experiments conducted (122% and 126% compared to controls). No changes were found in the levels of fibroblast MAO-A or platelet MAO-B activity. Possibly these alterations in glucose oxidation may be associated with a generalized membrane abnormality which has been reported in schizophrenia.
Ramchand
C N
CN
Institute of Biological Psychiatry, University of Wales, Bangor, U.K.
Gliddon
A E
AE
Clark
A E
AE
Hemmings
G P
GP
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*
D008995:Monoamine Oxidase; D005947:Glucose