Cutaneous mastocytosis complicating pregnancy.
BACKGROUND
Telangiectasia macularis eruptiva perstans, a rare form of cutaneous mastocytosis associated with elevated histamine excretion, has not previously been reported to complicate pregnancy.


METHODS
A woman presented in the late second trimester with an anaphylactoid reaction, rash, uterine contractions, and vaginal bleeding. Skin biopsy revealed perivascular mast-cell infiltration. Her urinary histamine excretion was markedly elevated. She was treated successfully with tocolytics and antihistamines.


CONCLUSIONS
Elevated histamine excretion in biopsy-proven cutaneous mastocytosis may be associated with preterm labor.
Donahue
J G
JG
Department of Obstetrics and Gynecology, Indiana University Medical Center, Indianapolis, USA.
Lupton
J B
JB
Golichowski
A M
AM
D000328:Adult; D001034:Apgar Score; D001706:Biopsy; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008278:Magnesium Sulfate / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000473:pathology; D011262:Pregnancy Trimester, Second; D012867:Skin / Q000473:pathology; D014582:Urticaria Pigmentosa / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
D008278:Magnesium Sulfate