[Level of sodium and potassium in Streptomyces chrysomallus subsp. macrotetrolidi cells--producers of macrotetralide antibiotics].
The ionophoretic macrotetrolide antibiotics selective to monovalent cations K+ and mainly to NH4+ were determined during the lag period of culture growth. At this stage the cells contain the maximal amounts of Na+ and K+. Macrotetrolides, whose selectivity to Na+ and K+ varies, can regulate the intracellular content of these cations by participating in the cation transport. The authors propose that the cells possess furosemide sensitivity and K+/Na+ ATPase transport systems.
Sverdlova
A N
AN
Agbenoko
K
K
Mazenko
I V
IV
Iaglova
L G
LG
Egorov
N S
NS
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media; D017136:Ion Transport; D018942:Macrolides; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013302:Streptomyces / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D018942:Macrolides; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
Soderzhanie natriia i kaliia v kletokakh Streptomyces shrysomallus subsp. macrotetrolidi--produtsenta makrotetralidnykh antibiotikov.