Hydrochlorothiazide-induced pulmonary edema with severe acute myocardial dysfunction.
A 73-year-old woman presented with acute pulmonary edema and hypotension less than 1 h after taking hydrochlorothiazide 50 mg, a reaction which has been reported as a rare but classic adverse drug response. Though prior cases have supported a noncardiogenic pulmonary edema syndrome, hemodynamic monitoring in this patient demonstrated a refractory low cardiac output state for more than 24 h. In the absence of other etiologies, this represents a new finding.
Frierson
J H
JH
Department of Medicine, Salem Hospital, Oregon, USA.
Marvel
S L
SL
Thomas
G M
GM
D000208:Acute Disease; D000368:Aged; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D007022:Hypotension / Q000139:chemically induced; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000503:physiopathology; D018754:Ventricular Dysfunction / Q000139:chemically induced* / Q000503:physiopathology
D006852:Hydrochlorothiazide