title: Scintigraphic evaluation of pancreatic transplants using technetium-99m-sestamibi.
abstract: The purpose of this study was to evaluate the feasibility of using 99mTc-sestamibi in the assessment of pancreatic transplant.
  
  
  METHODS
  Ten transplant recipients with a history of insulin-dependent diabetes mellitus were studied. Fourteen 99mTc-sestamibi studies were performed. Each patient was injected intravenously with 10 mCi of 99mTc-sestamibi. Two-second frames were obtained for 1 min, followed by serial dynamic and static images every 5 min for 30 min. Technetium-99m sestamibi studies, read by two nuclear medicine physicians, were correlated with clinicopathologic findings and compared to the ten 201Tl studies obtained in seven of these patients.
  
  
  RESULTS
  On 99mTc-sestamibi images, normally functioning grafts showed adequate perfusion on the angiogram and good uptake followed by clearance on static images. Time-activity curves showed an initial upslope followed by a downslope after the initial uptake peak. The quality of 99mTc-sestamibi images was superior to those of 201Tl in five, similar in four and marginally inferior in one paired study. Technetium-99m-sestamibi was used for both flow and static images, whereas a 99mTc radiotracer angiogram was needed to accompany the 201Tl study.
  
  
  CONCLUSIONS
  Our preliminary experience indicates that 99mTc-sestamibi helps evaluate pancreatic transplants and provides high count statistics, which result in better image quality and diagnostic detail. Extensive quantitative studies are being performed to further evaluate this agent's role in the clinical management of pancreatic transplant patients.
authors.affiliation: Department of Radiology, University of Cincinnati Hospital, Ohio, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Elgazzar
authors.forename: R
authors.initials: R
authors.lastname: Munda
authors.forename: M
authors.initials: M
authors.lastname: Fernandez-Ulloa
authors.forename: J
authors.initials: J
authors.lastname: Clark
authors.forename: J R
authors.initials: JR
authors.lastname: Ryan
authors.forename: J A
authors.initials: JA
authors.lastname: Hughes
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006084:Graft Rejection / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging*; D016035:Pancreas Transplantation / Q000009:adverse effects; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes
chemical_list: D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi