SPECT imaging of gliomas with Thallium-201 and Technetium-99m-HMPAO.
Sequential Thallium-201 and Technetium-99m-HMPAO SPECT images were obtained from 7 patients with high-grade gliomas and 5 patients with low-grade gliomas. The histo-pathological tumor-type was verified from either biopsy specimens or resected tissue from surgery. There was an intense uptake of Thallium-201 in all high-grade gliomas. Compared to the contralateral hemisphere the mean uptake was 4.6 times higher. Low-grade gliomas showed only a marginally increased Thallium-201 uptake (1.4 times). No overlap existed between the two groups. There was no correlation between Technetium-99m-HMPAO uptake and tumor type. Thallium-201 appears to be a promising radiopharmaceutical for differentiating high- and low-grade gliomas, whereas Technetium-99m-HMPAO is not.
Sjöholm
H
H
Department of Clinical Neurophysiology, University Hospital, Lund, Sweden.
Elmqvist
D
D
Rehncrona
S
S
Rosén
I
I
Salford
L G
LG
D000328:Adult; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D013667:Technetium; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon
D013667:Technetium; D013793:Thallium