title: Hepatic metastases from soft-tissue sarcoma.
abstract: OBJECTIVE
  Hepatic metastases from soft-tissue sarcoma are evaluated to define treatment and its limitations.
  
  
  METHODS
  From 981 adult patients with diagnoses of soft-tissue sarcoma, 65 patients with hepatic metastases were studied.
  
  
  RESULTS
  An intra-abdominal primary site was present in 61 of 65 patients, with 85% high-grade leiomyosarcoma. Hepatic resection was performed in 14 patients (22%). All patients have had recurrences after hepatic resection-11 of 14 in the liver--with a median survival of 30 months. Chemotherapy resulted in partial response in three patients and no complete responses. Survival is not influenced by grade, type, primary site, disease-free interval, chemotherapy, or hepatic resection.
  
  
  CONCLUSIONS
  The uncommon response to conventional chemotherapy does not support its use in the treatment of hepatic metastases from soft-tissue sarcoma. Extent of disease limits the application and success of hepatic resection for soft-tissue sarcoma, and anything less than complete resection is not indicated.
authors.affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Jaques
authors.forename: D G
authors.initials: DG
authors.lastname: Coit
authors.forename: E S
authors.initials: ES
authors.lastname: Casper
authors.forename: M F
authors.initials: MF
authors.lastname: Brennan
mesh_terms: D000328:Adult; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology / Q000556:secondary* / Q000628:therapy; D012509:Sarcoma / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate