Rhinitis as a mechanism of respiratory defense.
The incidence of rhinitis is on the increase, especially in towns and cities with high levels of pollution from motor traffic and industry. There is a growing body of evidence which links this increased incidence of rhinitis to chronic nasal irritation from industrial pollution. Studies on the mechanisms of nasal inflammation and the nasal immune response are now providing insights into the etiology of rhinitis. This knowledge will help in the development of therapies aimed at alleviating the symptoms of rhinitis and controlling the development of rhinitis in susceptible individuals. This review discusses some of the factors that may explain the increased incidence of rhinitis and examines basic mechanisms involved in the nasal response to infection and allergy.
Eccles
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Common Cold and Nasal Research Centre, School of Molecular and Biomedical Sciences, University of Wales College of Cardiff, UK.
D000397:Air Pollution / Q000009:adverse effects; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D006801:Humans; D009666:Nose / Q000276:immunology / Q000503:physiopathology; D009668:Nose Diseases / Q000503:physiopathology / Q000821:virology; D012130:Respiratory Hypersensitivity / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D012220:Rhinitis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D012912:Sneezing / Q000502:physiology