title: [Light and electron microscopic histochemical studies of alkaline phosphatase (ALP) isoenzymes in gastric cancer].
abstract: By using light and electron microscopic histochemical techniques, the activities and distributions of ALP isoenzymes in gastric cancers and benign gastric diseases were examined. The results showed: Nagao, Regan and Kasahara isoenzymes, which were not expressed in normal gastric mucosae and non-malignant lesions, may be considered as the tumor markers of gastric cancer. The epithelium of intestinal metaplasia exhibited intestinal-type ALP only, which was one of the markers of well-differentiated intestinal metaplasia. In the view-point of the gene expression of ALP isoenzymes, two mutation hypothesis and recessive-gene mutation hypothesis may be proper for gastric cancer.
authors.affiliation: Department of Pathology, Anhui Medical University, Hefei.
authors.forename: Y H
authors.initials: YH
authors.lastname: Su
authors.forename: G L
authors.initials: GL
authors.lastname: Yang
authors.forename: Y M
authors.initials: YM
authors.lastname: Dong
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D058851:GPI-Linked Proteins; D005753:Gastric Mucosa / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D011230:Precancerous Conditions / Q000201:enzymology* / Q000235:genetics; D013274:Stomach Neoplasms / Q000201:enzymology*
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D007527:Isoenzymes; C055791:germ-cell AP isoenzyme; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental