title: Progress in the immunogenetics of rheumatoid arthritis.
abstract: Although much remains to be learned about environmental factors and putative pathogens, significant strides have been made on the genetic front. Genes appear to have a greater role in determining disease severity than disease risk. In particular, patients who are heterozygous for two HLA-DR4 subtypes are prone to severe erosive disease, making them candidates for early, aggressive therapy.
authors.affiliation: Institute of Molecular Medicine, University of Oxford, England.
authors.forename: P
authors.initials: P
authors.lastname: Wordsworth
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology*; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology*; D004198:Disease Susceptibility; D004782:Environmental Health; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics / Q000276:immunology; D015804:HLA-DR4 Antigen / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D008297:Male
chemical_list: D015804:HLA-DR4 Antigen