[Cancer of the prostate. 2. Physiology and cellular development].
Prostatic cancer is the second most frequent cancer in men in industrialised countries. The histological analysis of its initial development demonstrates the existence of precancerous lesions, PIN. The initial presence of several different cell populations accounts for the development of contingents of hormone-sensitive and hormone-resistant cells. The presence of numerous neuroendocrine cells appears to be a factor of poor prognosis. Hormones are intimately involved in the development of prostatic cancer and are an integral part of its treatment. Progress in molecular biology has furthered out knowledge of this disease. In particular, growth factors such as EGF and FGF are particularly involved and are starting to have a clinical application. The oncogene and anti-oncogene system is currently being explored (particularly p53 abd BCL 2). They are the basis for carcinogenesis and analysis of these factors will allow a better approach to the mechanisms of tumour induction and development.
Mottet
N
N
Service d'Urologie Andrologie, CHU de Nîmes.
Costa
P
P
Le Pellec
L
L
Louis
J F
JF
Navratil
H
H
D000728:Androgens / Q000502:physiology; D004815:Epidermal Growth Factor / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D006801:Humans; D008297:Male; D009490:Neurosecretory Systems / Q000473:pathology; D009857:Oncogenes / Q000235:genetics; D011230:Precancerous Conditions / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*
D000728:Androgens; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor
Cancer de prostate. 2. Physiologie et développement cellulaire.