title: CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila.
abstract: Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed.
authors.affiliation: Cold Spring Harbor Laboratory, New York 11724, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Yin
authors.forename: M
authors.initials: M
authors.lastname: Del Vecchio
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: T
authors.initials: T
authors.lastname: Tully
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001362:Avoidance Learning; D017362:Cyclic AMP Response Element-Binding Protein / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D015870:Gene Expression; D017344:Genes, Insect; D006358:Hot Temperature; D008568:Memory / Q000502:physiology*; D008957:Models, Genetic; D009154:Mutation / Q000502:physiology; D010766:Phosphorylation; D015534:Trans-Activators / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D015534:Trans-Activators