title: Increased CSF C4d in demyelinating neuropathy indicates the radicular involvement.
abstract: Plasma and cerebrospinal fluid (CSF) levels of C4d and the circulating immune complex (CIC) to C1q were measured in 12 patients with chronic inflammatory demyelinating polyneuropathy and Guillain-Barré syndrome. CSF C4d values more than 2 SD from the mean of 8 cervical spongylosis cases were demonstrated in the patients with proximal demyelination. The CSF C4d probably originated from both intrathecal synthesis and the systemic circulation. CSF levels of C4d may serve as a sensitive indicator for the radicular involvement in demyelinating polyneuropathy.
authors.affiliation: Department of Neurology, School of Medicine, Chiba University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Koguchi
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Kuwabara
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Hirayama
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins; D002574:Cervical Vertebrae / Q000503:physiopathology*; D003181:Complement C4 / Q000134:cerebrospinal fluid*; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid* / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007107:Immune System; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid*; D012709:Serum Albumin; D013053:Spectrophotometry; D013128:Spinal Osteophytosis / Q000134:cerebrospinal fluid* / Q000503:physiopathology*
chemical_list: D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D003181:Complement C4; D012709:Serum Albumin