title: [Bilateral ankle ulcers associated with hydroxyurea therapy for chronic myelogenous leukemia].
abstract: Bilateral ankle skin ulcers developed in a 61-year-old man in the chronic phase of chronic myelogenous leukemia receiving hydroxyurea therapy. The circulating immune complex (anti-C3d antibody) was high in this case, but vasculitis was not observed in the pathological findings of biopsied skin materials. This association has been reported in patients who had chronic myelogenous leukemia or other myeloproliferative disorders and were treated with hydroxyurea. It is likely that skin ulcers are caused by hydroxyurea.
authors.affiliation: Second department of Internal Medicine, Jikei University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Masuoka
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Kaito
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Sekita
authors.forename: A
authors.initials: A
authors.lastname: Saeki
authors.forename: K
authors.initials: K
authors.lastname: Nishiwaki
authors.forename: T
authors.initials: T
authors.lastname: Shimada
authors.forename: S
authors.initials: S
authors.lastname: Ochiai
authors.forename: H
authors.initials: H
authors.lastname: Ootsubo
mesh_terms: D016523:Foot Ulcer / Q000139:chemically induced*; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D006918:Hydroxyurea