title: Changes in metabolism of cerebral glucose after stereotactic leukotomy for refractory obsessive-compulsive disorder: a case report.
abstract: Brain glucose metabolism was investigated with PET and [18F]fluorodeoxyglucose, before and after a bifrontal stereotactic leukotomy in a 37 year old woman with refractory obsessive-compulsive disorder. A bilateral decrease in glucose metabolism was found in the orbital frontal cortex after psychosurgery. Glucose metabolism was decreased to a lesser degree in Brodmann's area 25, in the thalamus, and in the caudate nucleus. Clinical improvement in obsessive-compulsive disorder after stereotactic tractotomy seems to be associated with metabolic changes in the brain, in particular, in the orbital part of the frontal lobe.
authors.affiliation: Erasme Hospital, Free University of Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Biver
authors.forename: S
authors.initials: S
authors.lastname: Goldman
authors.forename: A
authors.initials: A
authors.lastname: François
authors.forename: C
authors.initials: C
authors.lastname: De La Porte
authors.forename: A
authors.initials: A
authors.lastname: Luxen
authors.forename: B
authors.initials: B
authors.lastname: Gribomont
authors.forename: F
authors.initials: F
authors.lastname: Lotstra
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005625:Frontal Lobe / Q000601:surgery; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery*; D011612:Psychosurgery; D013238:Stereotaxic Techniques; D014055:Tomography, Emission-Computed
chemical_list: D005947:Glucose