Experimental study on antiatherosclerotic treatment by PGE2 combined with vitamin E and estradiol.
The effects of single dose of PGE2 combined with vitamin E and with estradiol on experimental atherosclerosis were studied by means of morphological, ultrastructural, autoradiographic and several functional techniques. The results showed that two combined treatment groups had more coordinative inhibition on aortic and coronary atherosclerotic lesions, as well as on platelet aggregation, smooth muscle cell proliferation and lipid peroxidation than that of single dose of PGE2. It was revealed that the coordinative mechanism might be closely related to the synergistic inhibitory function of above-mentioned drugs on endothelial permeability, platelet aggregation, smooth muscle cell proliferation and lipid peroxidation.
Qiu
J
J
Department of Pathology, Tianjin Medical University.
Gao
Y
Y
Fan
Y
Y
Wang
X
X
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000473:pathology; D015232:Dinoprostone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004730:Endothelium, Vascular / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011817:Rabbits; D014810:Vitamin E / Q000008:administration & dosage*
D010975:Platelet Aggregation Inhibitors; D014810:Vitamin E; D004958:Estradiol; D015232:Dinoprostone