The formation of peroxynitrite in vivo from nitric oxide and superoxide.
Peroxynitrite is predicted to be formed in vivo from the reaction of nitric oxide and superoxide. Nitric oxide at concentrations as low as 3 nM is expected to compete efficiently for superoxide near the surface of endothelial cells, based on competition kinetics.
Squadrito
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GL
Biodynamics Institute, Louisiana State University, Baton Rouge 70803, USA.
Pryor
W A
WA
D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D007700:Kinetics; D009566:Nitrates / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
D009566:Nitrates; D013481:Superoxides; C039642:peroxynitric acid; D009569:Nitric Oxide