title: Left ventricular failure complicating severe pediatric burn injuries.
abstract: OBJECTIVE
  Despite improvements in the overall survival rates for critically burned children, failed resuscitation may account for 54% of deaths following burn injuries. Clinical and experimental studies have implicated failure of the right side of the heart in adults, biventricular failure in elderly patients, and inadequate resuscitation as causes of refractory burn shock. This retrospective study of resuscitation at a tertiary pediatric burn center showed that myocardial depression is a complicating factor in the treatment of the pediatric burn victim.
  
  
  METHODS
  From 1989 to 1992, 28 critically burned children (> or = 60% total burn surface area) were resuscitated primarily at our center (admission within 24 hours of injury). Twenty-seven children had central lines, nine of whom underwent pulmonary artery catheterization for intensive hemodynamic monitoring because standard resuscitative therapy had failed. The average amount of fluid received at 8 and 24 hours after injury was within 10% of the calculated volume based on the Parkland formula.
  
  
  RESULTS
  Indexes of a failing rescue attempt included respiratory distress (PaO2/FlO2 < or = 200), central venous pressure of greater than 10 mm Hg, and urine output of less than 1 mL/kg/h. Filling pressures were found to be normal or elevated in all children, indicating adequate volume replacement. Evaluation of cardiac function was performed using a thermodilution technique and showed that 100% of the study group had depressed left ventricular function, with an average left ventricular stroke work index (LVSWI) of 19.9 g.m/m2 (normal, 44 to 68 g.m/m2), whereas only 38% had concomitant right ventricular failure. This left-sided dysfunction persisted throughout the acute resuscitation period but was improved after appropriate modification of fluid resuscitation and initiation of vasopressors (average final LVSWI, 38.0 g.m/m2). There were no complications from placement of the Swan-Ganz catheters in this group.
  
  
  CONCLUSIONS
  Cardiogenic failure is a major determinant of a failing pediatric burn resuscitation, and, contrary to the adult burn patient, the myocardial depression is predominantly left-sided. Information from pulmonary artery catheters can help direct therapy by providing indications for vasopressors and modifying fluid resuscitation.
authors.affiliation: Pediatric Surgical Services, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Reynolds
authors.forename: D P
authors.initials: DP
authors.lastname: Ryan
authors.forename: R L
authors.initials: RL
authors.lastname: Sheridan
authors.forename: D P
authors.initials: DP
authors.lastname: Doody
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002056:Burns / Q000150:complications*; D002407:Catheterization, Swan-Ganz; D002648:Child; D002675:Child, Preschool; D004280:Dobutamine / Q000627:therapeutic use; D005440:Fluid Therapy / Q000009:adverse effects; D006323:Heart Arrest / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D007223:Infant; D012131:Respiratory Insufficiency / Q000150:complications / Q000628:therapy; D012151:Resuscitation / Q000379:methods*; D012189:Retrospective Studies; D012770:Shock, Cardiogenic / Q000517:prevention & control; D012774:Shock, Traumatic / Q000150:complications / Q000628:therapy*; D018487:Ventricular Dysfunction, Left / Q000150:complications*
chemical_list: D004280:Dobutamine