Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.
Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central unresolved issue in acquired immunodeficiency syndrome (AIDS) pathogenesis is the mechanism underlying this T cell depletion. HIV-1 Tat protein was shown to induce cell death by apoptosis in a T cell line and in cultured peripheral blood mononuclear cells from uninfected donors. This Tat-induced apoptosis was inhibitable by growth factors and was associated with enhanced activation of cyclin-dependent kinases.
Li
C J
CJ
Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, MA, USA.
Friedman
D J
DJ
Wang
C
C
Metelev
V
V
Pardee
A B
AB
D017209:Apoptosis; D001483:Base Sequence; D042846:CDC2-CDC28 Kinases; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004789:Enzyme Activation; D015696:Gene Products, tat / Q000494:pharmacology / Q000502:physiology*; D015756:Genes, tat; D015497:HIV-1; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology* / Q000201:enzymology; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology* / Q000201:enzymology; D014162:Transfection; D014407:Tumor Cells, Cultured; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D011994:Recombinant Proteins; D054322:tat Gene Products, Human Immunodeficiency Virus; D017346:Protein Serine-Threonine Kinases; D042846:CDC2-CDC28 Kinases; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases