Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and Gerhardt syndrome associated with Shy-Drager syndrome.
This is the first report on a case of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with Gerhardt syndrome (paralysis of bilateral vocal cords). A 67-year-old Japanese man suffering from progressive autonomic failure was diagnosed as having Shy-Drager syndrome (SDS) with hyponatremia due to SIADH and severe sleep apnea caused by a bilateral recurrent nerve palsy. Water load test showed alteration in diuresis which was corrected by phenytoin. Arginine vasopressin secretion was not suppressed by plasma osmolality below 280 mOsm/kgH2O. Impairment of the afferent pathways of baroreceptors, or impairment of the osmoreceptors could be speculated as the etiological factor of the SIADH observed in this case.
Sone
H
H
Department of Endocrinology and Metabolism, University of Tsukuba.
Okuda
Y
Y
Bannai
C
C
Suzuki
S
S
Yamaoka
T
T
Asakura
Y
Y
Kawakami
Y
Y
Odawara
M
M
Matsushima
T
T
Kawai
K
K
D000368:Aged; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications* / Q000209:etiology; D008297:Male; D012791:Shy-Drager Syndrome / Q000150:complications*; D014826:Vocal Cord Paralysis / Q000150:complications*