[The participation of prostaglandin F2 in the peroxidation damages and antiperoxidation protection of the parotid gland in acute nonepidemic parotitis].
Effects of prostaglandin F2 on the major components of the antioxidative system (levels of malonic dialdehyde and lipid peroxides, activities and content of glutathione enzymes and nonenzymes (glutathione peroxidase, glutathione reductase, and NADPH (NADH), oxidized and reduced glutathione) were studied in experiments with 60 dogs in which acute nonepidemic parotitis was modeled. A varying capacity of the cells of the parotid gland to resist the detrimental effects of the disease and specific features of prostaglandin F2 effect on this capacity were revealed: injection of prostaglandin F2 stimulated both lipid peroxidation and the activity of the antioxidative system and led to cellular injury in the presence of a relatively high level of cellular metabolism, preserving cellular viability on condition of inhibited rate of metabolic reactions, this being the principal factor for the parotid gland, among other factors determining the cytoprotective effect.
Dolgov
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Filipenko
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PS
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants; D015237:Dinoprost / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D015227:Lipid Peroxidation / Q000187:drug effects*; D010195:Pancreatitis / Q000188:drug therapy / Q000378:metabolism; D010306:Parotid Gland / Q000187:drug effects* / Q000378:metabolism; D010309:Parotitis / Q000188:drug therapy* / Q000378:metabolism
D000975:Antioxidants; D015237:Dinoprost
Uchastie prostaglandina F2 v perekisnykh povrezhdeniiakh i antiperekisnoĭ zashchite okoloushnoĭ sliunnoĭ zhelezy pri ostrom neépidemicheskom parotite.