title: [Optic disc and choroidal circulation detected by dye-filling rate in indocyanine green angiography].
abstract: Dye-filling rate of optic disc and choroid in normal human subjects was investigated using indocyanine green infra-red videoangiography and computerized image analysis. Only relative changes in the circulation of disc and choroid could be studied and the ratio (D/M) of dye-filling rate in normal subjects (age ranged 23-62) in disc (D) to choroid (M) was reliable. Intraocular pressure (IOP) was elevated to two levels with a pneumatic suction-cup. When D/M at normal IOP was 1, mean D/M was 1. 29 when mean IOP was 26.8 mmHg, and 1.48 when mean IOP was 38.4 mmHg. The results suggest that IOP elevation produced less change in the disc circulation than in the choroid. The ratio of dye-filling rate of the disc at 38.4 mmHg to normal IOP was significantly correlated (P < 0.05) with perfusion pressure at normal IOP, showing that the autoregulatory mechanisms in the disc blood flow may possibly reach the limit especially in subjects whose perfusion pressure is low.
authors.affiliation: Department of Ophthalmology, Izumiotsu City Hospital, Osaka-fu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kitanishi
authors.forename: S
authors.initials: S
authors.lastname: Harino
authors.forename: I
authors.initials: I
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000792:Angiography / Q000379:methods; D002829:Choroid / Q000098:blood supply*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007208:Indocyanine Green / Q000493:pharmacokinetics; D007259:Infrared Rays; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000098:blood supply*; D012039:Regional Blood Flow
chemical_list: D007208:Indocyanine Green