title: Use of urine albumin measurement as a replacement for total protein.
abstract: We have investigated the replacement of urine total protein estimations for the assessment of glomerular permeability, by the measurement of urine albumin excretion using a latex particle enhanced immunoturbidimetric assay. An initial screen was performed using Albustix to assess the sample pre-dilution necessary for immunoanalysis. A total of 167 24-hour urine samples were analysed and urine albumin concentration correlated well with that of urine total protein (r = 0.93) over the range 0-16,800 mg/l. This protocol provides a more cost effective and analytically valid assessment of glomerular permeability.
authors.affiliation: Department of Clinical Biochemistry, London Hospital Medical College, England, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Newman
authors.forename: H
authors.initials: H
authors.lastname: Thakkar
authors.forename: E A
authors.initials: EA
authors.lastname: Medcalf
authors.forename: M R
authors.initials: MR
authors.lastname: Gray
authors.forename: C P
authors.initials: CP
authors.lastname: Price
mesh_terms: D000419:Albuminuria / Q000175:diagnosis / Q000652:urine*; D006801:Humans; D009391:Nephelometry and Turbidimetry; D011507:Proteinuria / Q000175:diagnosis / Q000652:urine*; D011934:Reagent Strips
chemical_list: D011934:Reagent Strips