title: Plasma von Willebrand factor antigen concentration in dogs with hypothyroidism.
abstract: Plasma von Willebrand factor antigen concentration was measured in 10 dogs with hypothyroidism, before and after administration of a replacement dose of levothyroxine for 67 +/- 12 days. Results were reported as a percentage of normal activity, with plasma pooled from clinically normal dogs given a value of 100%. Plasma von Willebrand factor antigen concentration was within reference limits in dogs with hypothyroidism (126 +/- 41%) and was significantly (P < 0.01) decreased (94 +/- 39%) after treatment with levothyroxine. Contrary to findings in some other studies, a deficiency of plasma von Willebrand factor did not appear to result from hypothyroidism.
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
authors.forename: D L
authors.initials: DL
authors.lastname: Panciera
authors.forename: G S
authors.initials: GS
authors.lastname: Johnson
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D004285:Dogs; D007037:Hypothyroidism / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use*; D014842:von Willebrand Diseases / Q000209:etiology / Q000662:veterinary; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D014841:von Willebrand Factor; D013974:Thyroxine