title: The porphyrias and hepatocellular carcinoma.
abstract: Hepatocellular carcinoma probably represents the final step of the effects of the various precipitating agents for porphyria cutanea tarda, such as alcohol, drugs, hormones, and hepatitis C infection. Risk factors associated with its development include male gender, age over 50 years, liver fibrosis or cirrhosis, and a long history (over 10 years) of symptomatic porphyria cutanea tarda.
authors.affiliation: Department of Veternas Affairs Medical Center, New York, New York, USA.
authors.forename: H W
authors.initials: HW
authors.lastname: Lim
authors.forename: J M
authors.initials: JM
authors.lastname: Mascaro
mesh_terms: D000328:Adult; D000367:Age Factors; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017119:Porphyria Cutanea Tarda / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D012307:Risk Factors; D012737:Sex Factors; D014575:Uroporphyrinogen Decarboxylase / Q000172:deficiency
chemical_list: D014575:Uroporphyrinogen Decarboxylase