MRI abnormalities in major psychiatric disorders: an exploratory comparative study.
MRI scan reports from 536 psychiatric inpatients in 10 DSM-III-R diagnostic categories and 51 normal control subjects were reviewed for incidence and severity of four types of abnormality: deep white matter hyperintensities, periventricular hyperintensities, ventricular enlargement, and cortical atrophy. Multivariate analysis revealed significant effects for both diagnosis and age and a significant interaction. After age covariance, the most discriminant type of abnormality was ventricular enlargement, with normal control subjects having significantly less enlargement than 6 of 10 patient groups, including the personality disorder and the depressed nonpsychotic groups. The data also suggested important diagnosis by age by type-of-abnormality interactions deserving of further study.
Woods
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BT
Department of Neurology, McLean Hospital, Belmont MA, USA.
Brennan
S
S
Yurgelun-Todd
D
D
Young
T
T
Panzarino
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D001523:Mental Disorders / Q000473:pathology*; D008875:Middle Aged