title: Enhanced susceptibility of audiogenic seizures in Fyn-kinase deficient mice.
abstract: Mice with a mutation in fyn genes were examined for their susceptibility to acoustically primed audiogenic seizures. Homozygous mutant (fynz/fynz) mice were significantly more likely to have seizures and to show the stronger seizure syndrome (clonus). These results indicate that the susceptibility of acoustically primed audiogenic seizures is enhanced in the Fyn kinase deficient mice.
authors.affiliation: Department of Psychology, Faculty of Letters, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyakawa
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: K
authors.initials: K
authors.lastname: Tateishi
authors.forename: H
authors.initials: H
authors.lastname: Niki
mesh_terms: D000818:Animals; D004830:Epilepsy, Tonic-Clonic; D005796:Genes; D051379:Mice; D008957:Models, Genetic; D009154:Mutation; D010770:Phosphotransferases / Q000378:metabolism*; D012640:Seizures / Q000235:genetics*; D001616:beta-Galactosidase / Q000235:genetics
chemical_list: D010770:Phosphotransferases; D001616:beta-Galactosidase