title: [Binding of amaranthin in human retina].
abstract: The binding of amaranthin, specific for Gal beta 1,3 GalNAc and sialic acid Gal beta 1,3 GalNAc sequences, to the human retina was investigated with avidin biotinylated peroxidase. Amaranthin bound to the cone and rod photoreceptors, inner plexiform layer, ganglion cells, and nerve fibers. Since peanut agglutinin, specific for Gal beta 1,3 GalNAc, selectively binds to cones, we conclude that O-glycoside-linked glycoconjugates are present on the surfaces of both cones and rods: Gal beta 1,3 GalNAc and sialic acid Gal beta 1,3 GalNAc are terminal sugars of the glycoconjugates around cones and rods, respectively.
authors.affiliation: Department of Ophthalmology, Kagoshima University Faculty of Medicine.
authors.forename: F
authors.initials: F
authors.lastname: Uehara
authors.forename: M
authors.initials: M
authors.lastname: Sameshima
authors.forename: K
authors.initials: K
authors.lastname: Unoki
authors.forename: A
authors.initials: A
authors.lastname: Okubo
authors.forename: T
authors.initials: T
authors.lastname: Yanagita
authors.forename: M
authors.initials: M
authors.lastname: Sugata
authors.forename: N
authors.initials: N
authors.lastname: Iwakiri
authors.forename: N
authors.initials: N
authors.lastname: Ohba
mesh_terms: D006001:Glycoconjugates / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D010786:Photoreceptor Cells / Q000378:metabolism; D037121:Plant Lectins; D012160:Retina / Q000378:metabolism*; D054788:Ribosome Inactivating Proteins; D054789:Ribosome Inactivating Proteins, Type 1
chemical_list: D006001:Glycoconjugates; D037102:Lectins; D037121:Plant Lectins; D054789:Ribosome Inactivating Proteins, Type 1; C061152:amaranthin protein, Amaranthus; D054788:Ribosome Inactivating Proteins