title: Fibronectin and sialic acid levels in human meningiomas and gliomas.
abstract: In this study, fibronectin and sialic acid levels have been assayed in human meningiomas and gliomas. The mean fibronectin and sialic acid levels for human meningiomas were 22.01 +/- 9.70 micrograms/mg protein and 19.58 +/- 4.89 micrograms/mg protein, respectively, and for human gliomas were 27.30 +/- 13.70 micrograms/mg protein and 25.67 +/- 11.60 micrograms/mg protein, respectively, versus 9.23 +/- 5.40 micrograms/mg protein and 13.50 +/- 4.30 micrograms/mg protein for normal brain tissues. Fibronectin and sialic acid levels were significantly higher in human meningiomas (P < 0.01 and P < 0.05) and gliomas (P < 0.001 and P < 0.01) than control group. Also the mean fibronectin and sialic acid levels were found to be 18.27 +/- 7.08 micrograms/mg protein and 17.04 +/- 6.25 micrograms/mg protein in Grade I-II and 32.60 +/- 15.00 micrograms/mg protein and 29.50 +/- 11.60 micrograms/mg protein in Grade III-IV gliomas, respectively. Fibronectin and sialic acid levels were significantly higher in Grade III-IV gliomas than Grade I-II gliomas (P < 0.05).
authors.affiliation: Department of Biochemistry, Cerrahpaşa Medical Faculty, University of Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Sönmez
authors.forename: E
authors.initials: E
authors.lastname: Kökoğlu
authors.forename: S
authors.initials: S
authors.lastname: Süer
authors.forename: E
authors.initials: E
authors.lastname: Ozyurt
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000737:chemistry; D005353:Fibronectins / Q000032:analysis*; D005910:Glioma / Q000737:chemistry*; D006801:Humans; D008577:Meningeal Neoplasms / Q000737:chemistry; D008579:Meningioma / Q000737:chemistry*; D009363:Neoplasm Proteins / Q000032:analysis; D012794:Sialic Acids / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D005353:Fibronectins; D009363:Neoplasm Proteins; D012794:Sialic Acids