title: [Fixation of tubules with radioactive technetium dimercaptosuccinate in parenchymal diseases of the kidney].
abstract: In order to evaluate tubular function 99mTc-DMS dynamic kidney scintigraphy and 99mTc-DMS uptake determinations were performed in 55 patients with endemic nephropathy, diabetic nephropathy and glomerulo nephritis. From 64-656th segment of computerized radiorenograms 99mTc-DMS uptake and curve slope were assessed and compared with the corresponding parameters of 20 healthy subjects. Both parameters were decreased in patients of all three groups. Tubular uptake of 99mTc-DMS measured during 60 sec. 4 hours after 99mTc-DMS administration, was decreased in endemic nephropathy and diabetic nephropathy, but without a significant difference in glomerulonephritic patients. The study of the relationship between 4 hour 99mTc-DMS tubular fixation and glomerular filtration rate, estimated by 99mTc-DTPA clearance, showed a positive correlation only in patients with diabetic nephropathy. Patients with renal failure from all three groups had more seriously impaired tubular handling of 99mTc-DMS, that correlated with reduction of the glomerular filtration rate. The present data showed more severe impairment of tubular function in patients with endemic nephropathy and diabetic nephropathy than in glomerulonephritic patients. The method was suitable for estimation of the tubular function.
authors.affiliation: Institute of Nephrology and Haemodialysis, University Clinical Centre, Nish.
authors.forename: M
authors.initials: M
authors.lastname: Rajić
authors.forename: M
authors.initials: M
authors.lastname: Bogićević
authors.forename: V
authors.initials: V
authors.lastname: Stefanović
mesh_terms: D001449:Balkan Nephropathy / Q000000981:diagnostic imaging / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007684:Kidney Tubules / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer
vernacular_title: Fiksacija u tubulima dimerkaptosukcinata oblezenog radioaktivnim tehnecijumom u parenhimskim oboljenjima bubrega.