title: Changes of calcemia and magnesemia during oral glucose tolerance test (OGTT) in relation to glucose tolerance.
abstract: We have examined 56 subjects with normal glucose tolerance (NGT), 33 with impaired glucose tolerance (IGT) and 15 diabetics type II (DM) by an oral glucose tolerance test with 75 g of glucose and in addition to glycemia and C-peptide we estimated also calcemia, magnesemia, ionized calcium level (plus corrected ionized calcium level) in all time intervals. The basal glycemia and C-peptide values were different in each examined group, while the magnesium values distinguished only the DM group from the others. The corrected Ca2+ in 60 min decreased significantly in DM, while after 120 min there were no differences in the values. Magnesemia in NGT decreased after 60 and 120 min, while by IGT and DM it rised in both such intervals. The difference between IGT and DM was highly significant. Our findings give evidence about the changes in the distribution of magnesium already at an early stage of decrease glucose tolerance. The importance of this finding for an early IGT diagnostics and its further classification still remains to be definitely evaluated.
authors.affiliation: Institute of Endocrinology, Prague, Czech Republic.
authors.forename: A
authors.initials: A
authors.lastname: Simecková
authors.forename: V
authors.initials: V
authors.lastname: Zamrazil
authors.forename: J
authors.initials: J
authors.lastname: Cerovská
authors.forename: P
authors.initials: P
authors.lastname: Stolba
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D002118:Calcium / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D008274:Magnesium; D005947:Glucose; D002118:Calcium