[Treatment of bladder cancer by Nd:YAG laser local irradiation and whole-bladder photodynamic therapy with hematoporphyrin derivative].
Twenty cases with 51 tumor foci of urinary bladder were treated by Nd:YAG laser local irradiation plus whole-bladder photodynamic therapy (PDT) with hematoporphyrin derivative (HPD). All cases were confirmed by histopathological diagnosis. Of the 20 patients, 19 were cured after one treatment (95%) and the other patient cured after 2 treatments within 40 days. On follow-up for 3-23 months, tumor recurrence occurred in 2 cases (10%) about 3-6 months after treatment. The results suggest that the PDT effect in destroying bladder tumors might be enhanced by Nd:YAG laser while the lesions escaped Nd:YAG laser irradiation could be handled by whole-bladder PDT.
Li
C L
CL
Department of Urological Oncology and Laser Medicine, Chinese Academy of Medical Sciences, Peking Union of Medical College, Beijing.
Xu
B Z
BZ
Shong
X Y
XY
D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D017324:Hematoporphyrin Derivative / Q000627:therapeutic use*; D006414:Hematoporphyrin Photoradiation; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*
D017324:Hematoporphyrin Derivative