[Quantitative study of P53 gene protein expression in the benign disease and cancer of breast].
P53 gene protein expression in breast benign disease and cancer was studied quantitatively using flow cytometry and cellular immunofluorescence staining technique. The results showed that P53 positive expression rate and content were lower in the benign disease of breast than that of the breast cancer. The content of P53 protein expression was also associated with the DNA ploidy in breast cancer. The content of P53 protein expression was higher in tumors with aneuploid cells than those with the diploid ones. The five year survival rate were also lower in P53 protein expression positive cases than the P53 negative one's.
Qi
F Y
FY
Hebei Medical College, Shijiazhuang.
Zuo
L F
LF
Zhen
Y J
YJ
D000236:Adenoma / Q000378:metabolism; D000782:Aneuploidy; D001943:Breast Neoplasms / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005348:Fibrocystic Breast Disease / Q000378:metabolism*; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53