title: Effects of chronic angiotensin I-converting enzyme inhibition on the relations between ventricular action potential changes and myocardial hypertrophy in aging rats.
abstract: We studied the effect of aging on cardiac hypertrophy and action potential duration (APD) in normotensive male WAG/Rij rats and evaluated the role of the renin-angiotensin system (RAS) in these effects. Cardiac hypertrophy occurs in 30-month-old rats, as indicated by an increase in heart weight, and APD gradually increases with aging in the epicardial region of the right and the left ventricle. Short-term treatment (1 month) with the angiotensin-converting enzyme inhibitor (ACEI) perindopril prevented age-related increase in heart weight/body weight ratio independent of its antihypertensive effects, but did not prevent changes in APD in 30-month-old rats. Our results show a dissociation of changes in cardiac mass from changes in APD during aging. The effect of ACEI on hypertrophy may be due in part to a direct angiotensin effect on cellular growth. Changes in APD are not related to hypertrophy but rather to the process of aging.
authors.affiliation: Laboratoire de Neurophysiologie, CNRS URA 611, Angers, France.
authors.forename: P
authors.initials: P
authors.lastname: Kreher
authors.forename: M T
authors.initials: MT
authors.lastname: Ristori
authors.forename: B
authors.initials: B
authors.lastname: Corman
authors.forename: J
authors.initials: J
authors.lastname: Verdetti
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000375:Aging / Q000473:pathology / Q000502:physiology; D000704:Analysis of Variance; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006332:Cardiomegaly / Q000503:physiopathology / Q000517:prevention & control*; D002455:Cell Division / Q000187:drug effects; D004195:Disease Models, Animal; D004594:Electrophysiology; D005856:Germ-Free Life; D006352:Heart Ventricles / Q000166:cytology / Q000187:drug effects*; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009929:Organ Size / Q000187:drug effects; D020913:Perindopril; D011897:Random Allocation; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D020913:Perindopril