Late injury of cancer therapy on the female reproductive tract.
The purpose of this article is to review the late effects of cancer therapy on the female reproductive tract. The anatomic sites detailed are the vulva, vagina, cervix, uterus, fallopian tubes, and ovaries. The available pathophysiology is discussed. Clinical syndromes are presented. Tolerance doses of irradiation for late effects are rarely presented in the literature and are reviewed where available. Management strategies for surgical, radiotherapeutic, and chemotherapeutic late effects are discussed. Endpoints for evaluation of therapeutic late effects have been formulated utilizing the symptoms, objective, management, and analytic (SOMA) format. Late effects on the female reproductive tract from cancer therapy should be recognized and managed appropriately. A grading system for these effects is presented. Endpoints for late effects and tolls for the evaluation need to be further developed.
Grigsby
P W
PW
Washington University School of Medicine, St. Louis, MO, USA.
Russell
A
A
Bruner
D
D
Eifel
P
P
Koh
W J
WJ
Spanos
W
W
Stetz
J
J
Stitt
J A
JA
Sullivan
J
J
D004305:Dose-Response Relationship, Drug; D005260:Female; D005836:Genitalia, Female / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D006801:Humans; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D011832:Radiation Injuries / Q000150:complications* / Q000473:pathology / Q000628:therapy; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects; D012735:Sexual Dysfunction, Physiological / Q000209:etiology; D014599:Uterus / Q000187:drug effects / Q000528:radiation effects; D014621:Vagina / Q000187:drug effects / Q000528:radiation effects; D014844:Vulva / Q000187:drug effects / Q000528:radiation effects