Hemodynamic effects of intravenous famotidine in patients undergoing cardiac surgery.
OBJECTIVE
To determine the hemodynamic effects of famotidine in patients undergoing cardiac surgery.


METHODS
A prospective, randomized, double-blinded, placebo-controlled study.


METHODS
A large university teaching hospital.


METHODS
Twenty-one patients undergoing elective cardiac surgery with cardiopulmonary bypass.


METHODS
The patients received a rapid intravenous bolus injection of famotidine 20 mg or saline placebo after anesthesia induction. A second dose was given 12 hours after surgery in the intensive care unit.


RESULTS
Serial hemodynamic measurements (heart rate, arterial blood pressure, cardiac index, pulmonary arterial pressure, central venous pressure, systemic vascular resistance) were obtained after each famotidine or placebo dose and analyzed by ANOVA: The values were not altered (p > 0.05) after intraoperative or postoperative famotidine or placebo administration.


CONCLUSIONS
Rapid intravenous bolus administration of famotidine does not alter patient hemodynamics after anesthesia induction or in the intensive care unit after cardiac surgery.
Wagner
B K
BK
College of Pharmacy, Rutgers University, Piscataway, NJ 08855-0789, USA.
DiFazio
L T
LT
Amory
D W
DW
Scott
G E
GE
Spotnitz
A J
AJ
D000368:Aged; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D004311:Double-Blind Method; D015738:Famotidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006785:Hospitals, University; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D014690:Venous Pressure / Q000187:drug effects
D015738:Famotidine