title: Multiple-dose pharmacokinetics of ceftibuten in healthy volunteers.
abstract: The pharmacokinetics of ceftibuten, a new cephalosporin antibiotic, and its conversion product, ceftibutentrans, were studied in healthy male volunteers following daily oral administration of a 400-mg capsule for 7 days. Mean concentrations of ceftibuten in plasma obtained on day 5 were similar to those obtained on day 7. Analysis of variance indicated that the concentrations in plasma on days 5 and 7 were at steady state. The mean accumulation factor was 1.14 for day 5 and 1.13 for day 7. The half-life (2.4 h) was independent of the duration of drug administration, and the mean maximum concentration of drug in plasma was 18 to 19 micrograms/ml. Urinary excretion was the major elimination route for ceftibuten, by which 57 to 59% of the drug was excreted unchanged over a 24-h period. The amounts of ceftibuten-trans in plasma and urine were low.
authors.affiliation: Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.
authors.forename: C
authors.initials: C
authors.lastname: Lin
authors.forename: E
authors.initials: E
authors.lastname: Radwanski
authors.forename: M
authors.initials: M
authors.lastname: Affrime
authors.forename: M N
authors.initials: MN
authors.lastname: Cayen
mesh_terms: D000328:Adult; D000077722:Ceftibuten; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male
chemical_list: D002511:Cephalosporins; D000077722:Ceftibuten