Antiproliferative activity of liposomal epirubicin on experimental human gliomas in vitro and in vivo after intratumoral/interstitial application.
Liposomal epirubicin was prepared using the controlled detergent dialysis method. The entrapment rate was 65.5 +/- 6.4%. The mean particle size was 210 +/- 38 nm. In vitro, a concentration-dependent antiproliferative activity of free epirubicin was observed. Liposome-entrapped epirubicin was superior to the free drug; the ID50 of the liposomal preparation was about 1.6-fold lower as compared to the free drug. Intratumoral/interstitial (i.t./i.s.) application of liposomal epirubicin was likewise superior to i.t./i.s. application of the free drug.
Todorov
D K
DK
Laboratory of Oncopharmacology, National Oncological Center, Sofia, Bulgaria.
Ninjo
S S
SS
Zeller
W J
WJ
D000818:Animals; D015251:Epirubicin / Q000008:administration & dosage*; D005260:Female; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D008081:Liposomes; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D008081:Liposomes; D015251:Epirubicin