Selective increase in expression of isoform PP1 gamma 1 of type-1 protein phosphatase in chondrosarcoma cells.
The expression of the two catalytic subunits of protein phosphatase (PP) type 1 PP1 gamma 1 and PP1 delta was examined in 4 cases of osteochondroma and 4 cases of enchondroma as a benign cartilaginous tumor, and 4 cases of chondrosarcoma as a malignant cartilaginous tumor using immunohistochemical analysis. The percentage of tumor cells stained positively with antiserum against PP1 catalytic subunit isoform PP1 gamma 1 were significantly higher in chondrosarcoma than in osteochondroma and enchondroma. Furthermore, chondrosarcoma showed markedly high S-phase fraction in the cell cycle of tumor cells, as compared to osteochondroma and enchondroma. These results suggest that PP1 gamma 1 is involved in the accelerated growth of malignant cells in chondrosarcoma.
Sogawa
K
K
Department of Pathology, Kagawa Medical School, Japan.
Yamada
T
T
Funamoto
Y
Y
Kohno
K
K
Nishikawa
H
H
Kishida
F
F
Hamazaki
F
F
Yamashita
N
N
Matsumoto
K
K
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000201:enzymology* / Q000473:pathology; D002453:Cell Cycle; D002455:Cell Division; D002812:Chondroma / Q000201:enzymology* / Q000473:pathology; D002813:Chondrosarcoma / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D015831:Osteochondroma / Q000201:enzymology* / Q000473:pathology; D010749:Phosphoprotein Phosphatases / Q000096:biosynthesis*
D007527:Isoenzymes; D010749:Phosphoprotein Phosphatases