Alleviation of cytotoxic therapy-induced normal tissue damage.
Cytotoxic chemotherapy and radiation therapy damage normal body tissues, resulting in stomatitis, conjunctivitis, esophagitis, proctitis, and dermatitis. Pursuant to this, the North Central Cancer Treatment Group has developed a series of clinical trials designed to study antidotes for these pathologic processes. These trials have demonstrated clinically helpful therapies (eg, oral cryotherapy for decreasing mucositis induced by 5-fluorouracil) and also have demonstrated lack of benefit for other proposed treatments. Results from several ongoing clinical trials should become available in the near future.
Loprinzi
C L
CL
Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Foote
R L
RL
Michalak
J
J
D002710:Chlorhexidine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D017679:Cryotherapy; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology; D004941:Esophagitis / Q000188:drug therapy* / Q000209:etiology; D005128:Eye Diseases / Q000139:chemically induced / Q000628:therapy*; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D011832:Radiation Injuries / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D013280:Stomatitis / Q000139:chemically induced / Q000628:therapy*; D013392:Sucralfate / Q000627:therapeutic use
D013392:Sucralfate; D002710:Chlorhexidine; D005472:Fluorouracil