Paeciloquinones A, B, C, D, E and F: new potent inhibitors of protein tyrosine kinase produced by Paecilomyces carneus. II. Characterization and structure determination.
Paeciloquinones A to F and versiconol have been isolated as inhibitors of protein tyrosine kinases from the culture broth of the fungus Paecilomyces carneus P-177. The structures of the new anthraquinones were determined by spectroscopic methods, mainly 1H NMR and 13C NMR. The substitution pattern was established by investigation of the respective methylated derivatives.
Fredenhagen
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A
Pharmaceutical Research Department, Ciba-Geigy Ltd., Basel, Switzerland.
Hug
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Sauter
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Peter
H H
HH
D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010143:Paecilomyces / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
D000880:Anthraquinones; C072370:versiconol; D011505:Protein-Tyrosine Kinases