[Suppressive effects of iodinated contrast media on human platelet aggregation].
Suppressive effects of several iodinated contrast media on stimulus-induced aggregation of human platelets were demonstrated. All contrast media, including ionic (iothalamate and ioxaglate) and non-ionic ones (iohexol, ioversol and iopamidol), suppressed the collagen- and thrombin-induced aggregation in a concentration-dependent manner. The effects of the former were much stronger than those of the latter. With ioxaglate, a similar inhibitory effect was also observed on PAF- and U46619-stimulated aggregation. The suppressive effect of ioxaglate on collagen-stimulated aggregation almost disappeared upon dilution of the medium with the platelet-poor plasma, suggesting that the effect is reversible.
Tamura
A
A
Graduate School of Health Science, Chukyo Women's University, Aichi, Japan.
Ohata
C
C
Hirakakiuchi
Y
Y
Sato
T
T
D003094:Collagen / Q000037:antagonists & inhibitors; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D066298:In Vitro Techniques; D007472:Iohexol / Q000009:adverse effects*; D007483:Iothalamic Acid / Q000009:adverse effects*; D007485:Ioxaglic Acid / Q000009:adverse effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors
D003287:Contrast Media; D010975:Platelet Aggregation Inhibitors; D007483:Iothalamic Acid; D007472:Iohexol; D003094:Collagen; D013917:Thrombin; D007485:Ioxaglic Acid