[Transforming growth factor-beta. An interesting candidate for clinical use].
Transforming growth factor-beta (TGF-beta) is the prototype of a large family of growth regulatory factors affecting the growth and differentiation of many cell types. Their action is mediated by complex formation of type I and type II receptors, both of which are serine/threonine kinases. TGF-beta inhibitors inhibit the growth of most cell types are potent immunosuppressive agents. They also stimulate the formation of connective tissue, thus promoting wound healing. TGF-beta and TGF-beta antagonists may have potential clinical uses in the treatment of various disorders.
Heldin
C H
CH
Ludwiginstitutet för cancerforskning.
Miyazono
K
K
D005355:Fibrosis / Q000628:therapy; D006801:Humans; D007107:Immune System / Q000502:physiology; D007166:Immunosuppressive Agents / Q000276:immunology; D009369:Neoplasms / Q000628:therapy; D016212:Transforming Growth Factor beta / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D014945:Wound Healing
D007166:Immunosuppressive Agents; D016212:Transforming Growth Factor beta
Transforming growth factor-beta. Intressant kandidat för klinisk användning.