title: Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function.
abstract: This study assessed whether the end-systolic pressure-volume relationship obtained without any interventions during pulsatile left ventricular bypass adequately represents native heart function. In 11 anesthetized Holstein calves, left ventricular pressure was measured with a micromanometer while left ventricular volume was simultaneously calculated from orthogonal left ventricular diameters measured with ultrasonic dimension transducers. End-systolic pressure and volume data were subjected to linear regression analysis to achieve an end-systolic pressure-volume relationship. Data from both caval occlusions and aortic occlusion were used for the control end-systolic pressure-volume relationship (median r = 0.941, slope = 7.4 +/- 0.8 mm Hg per milliliter per 100 gm left ventricular weight; mean +/- standard error of the mean). During left atrial-aortic bypass with a Pierce-Donachy pneumatic assist pump in the asynchronous mode, the end-systolic pressure-volume relationships were obtained without interventions to change ventricular loading conditions. During maximal ventricular unloading during full to empty pumping, termed 100%, the resulting narrow range of pressure and volume data did not yield highly linear end-systolic pressure-volume relationships (median r = 0.669, slope = 4.9 +/- 0.9 mm Hg per milliliter per 100 gm left ventricular weight). However, at reduced rates off pumping, the end-systolic pressure-volume relationships were considerably linear (80%, median r = 0.819; 60%, median r = 0.868; 40%, median r = 0.899). Slopes did not significantly differ from control values (80%, 6.9 +/- 1.1; 60%, 8.2 +/- 1.1; 40%, 7.8 +/- 1.1). The end-systolic pressure-volume relationship obtained without exogenous load changes during asynchronous, pulsatile left ventricular bypass represents native left ventricular systolic function.
authors.affiliation: Department of Surgery, College of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033, USA.
authors.forename: O
authors.initials: O
authors.lastname: Kawaguchi
authors.forename: J S
authors.initials: JS
authors.lastname: Sapirstein
authors.forename: W B
authors.initials: WB
authors.lastname: Daily
authors.forename: W E
authors.initials: WE
authors.lastname: Pae
authors.forename: W S
authors.initials: WS
authors.lastname: Pierce
mesh_terms: D000818:Animals; D002417:Cattle; D018611:Heart Bypass, Left; D006439:Hemodynamics; D009200:Myocardial Contraction; D013599:Systole; D016277:Ventricular Function, Left; D017725:Ventricular Pressure