[Consensus soft tissue tumors. Dutch Workgroup Soft-Tissue Tumors].
Soft-tissue sarcomas constitute a rare group of malignant tumours with histopathological features of connective, muscular, fatty or peripheral nervous tissue. The prognosis at manifestation depends on only two factors: the spread, both local and remote, and the biological behaviour of the tumour. The latter factor cannot be influenced but the former can: by inexpert manipulation. Consequently, tumours suspected of being soft-tissue sarcomas require multidisciplinary management from the beginning, with the team members familiar with each other's diagnostic and therapeutic skills. Imaging diagnostic methods should precede invasive methods for collection of material for pathological examination. The number of mitotic figures observed at microscopical examination of the tissue is an important prognostic feature. Surgical resection is the treatment of first choice. Radiotherapy is indicated in grade 3 tumours, after recurrence surgery, and when radical resection would involve too much mutilation. Chemotherapy is only given in the context of clinical trials. Surgical treatment of lung metastases may be indicated in selected patients. Regional isolated perfusion with tumour necrosis factor may be an alternative for limb amputation.
Van Geel
A N
AN
Dr. Daniel den Hoed Kliniek, afd. Chirurgische Oncologie, Rotterdam.
Van Unnik
J A
JA
Keus
R B
RB
D001706:Biopsy; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D006801:Humans; D010348:Patient Care Team; D011379:Prognosis; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy
Consensus weke-delentumoren. Nederlandse Werkgroep Weke-delentumoren.