title: Manganese toxicity: free amino acids in the striatum and olfactory bulb of the mouse.
abstract: We studied the levels of twenty two free amino acids in the striatum and olfactory bulb of mice treated during nine weeks with daily intraperitoneal injections of manganese chloride at a concentration of 5.0 mg Mn+2/kg body weight. In the olfactory bulb the contents of alanine, alpha-amino-n-butyrate, arginine, asparagine, aspartate, citrulline, GABA, glutamate, glycine, isoleucine, leucine, methionine, phenylalanine, serine, threonine, tyrosine, and valine were diminished. No alterations were observed in the concentrations of free amino acids in the striatum of Mn-treated mice. The changes detected in the olfactory bulb merit a thorough evaluation in order to determine its importance on the pathophysiology of manganese poisoning.
authors.affiliation: Instituto de Investigaciones Clínicas, Facultad de Medicina, Universidad del Zulia, Maracaibo-Venezuela.
authors.forename: E
authors.initials: E
authors.lastname: Bonilla
authors.forename: A
authors.initials: A
authors.lastname: Arrieta
authors.forename: F
authors.initials: F
authors.lastname: Castro
authors.forename: J O
authors.initials: JO
authors.lastname: Dávila
authors.forename: I
authors.initials: I
authors.lastname: Quiroz
mesh_terms: D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D003342:Corpus Striatum / Q000737:chemistry*; D008297:Male; D020149:Manganese Poisoning; D051379:Mice; D009830:Olfactory Bulb / Q000737:chemistry*
chemical_list: D000596:Amino Acids