title: Orbital infarction syndrome after surgery for intracranial aneurysms.
abstract: BACKGROUND
  Global orbital infarction results from ischemia of the intraocular and intraorbital structures due to hypoperfusion of the ophthalmic artery and its branches.
  
  
  METHODS
  The authors describe six patients in whom acute proptosis, ophthalmoplegia, and blindness developed immediately after surgery for intracranial aneurysms.
  
  
  RESULTS
  All patients underwent standard frontotemporal craniotomies to clip their aneurysms. In all patients, proptosis, ophthalmoplegia, and blindness developed in the immediate postoperative period; fundus abnormalities included retinal edema, retinal arteriolar narrowing and other vascular abnormalities, and pale optic disc swelling. Some patients had facial and corneal anesthesia. Ophthalmoplegia and facial anesthesia improved in most patients, but none regained any vision in the affected eye.
  
  
  CONCLUSIONS
  Orbital infarction syndrome is a rare complication of neurosurgical procedures. Increased orbital pressure probably reduced ophthalmic artery and collateral arterial perfusion, resulting in ischemia of the intraocular and intraorbital structures. There may be multiple factors that compound the risk for orbital infarction, and patients with subarachnoid hemorrhage, increased intracranial pressure, anomalous arterial or venous circulation, or impaired orbital venous outflow seem particularly vulnerable.
authors.affiliation: Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas 75235-9057, USA.
authors.forename: C F
authors.initials: CF
authors.lastname: Zimmerman
authors.forename: P D
authors.initials: PD
authors.lastname: Van Patten
authors.forename: K C
authors.initials: KC
authors.lastname: Golnik
authors.forename: T A
authors.initials: TA
authors.lastname: Kopitnik
authors.forename: R
authors.initials: R
authors.lastname: Anand
mesh_terms: D000328:Adult; D000368:Aged; D001766:Blindness / Q000209:etiology; D005094:Exophthalmos / Q000209:etiology; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007238:Infarction / Q000150:complications / Q000209:etiology*; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009886:Ophthalmoplegia / Q000000981:diagnostic imaging / Q000209:etiology; D009915:Orbit / Q000098:blood supply*; D011183:Postoperative Complications; D011859:Radiography; D013577:Syndrome