title: Recurrent congenital arthrogryposis leading to a diagnosis of myasthenia gravis in an initially asymptomatic mother.
abstract: We report a sibship in which the syndrome of congenital arthrogryposis occurred in two male and two female neonates, three of whom died. The mother was asymptomatic at the time of the first pregnancy and the subsequent development of muscle weakness was later confirmed to be due to myasthenia gravis. The literature on this association is briefly reviewed and the extremely high risk of recurrence of this complication in subsequent pregnancies is addressed.
authors.affiliation: University Department of Clinical Neurology, Radcliffe Infirmary, Oxford, U.K.
authors.forename: P R
authors.initials: PR
authors.lastname: Barnes
authors.forename: D J
authors.initials: DJ
authors.lastname: Kanabar
authors.forename: L
authors.initials: L
authors.lastname: Brueton
authors.forename: J
authors.initials: J
authors.lastname: Newsom-Davis
authors.forename: S M
authors.initials: SM
authors.lastname: Huson
authors.forename: N P
authors.initials: NP
authors.lastname: Mann
authors.forename: D
authors.initials: D
authors.lastname: Hilton-Jones
mesh_terms: D000328:Adult; D001176:Arthrogryposis / Q000235:genetics* / Q000473:pathology; D004550:Elbow / Q000473:pathology; D005190:Family; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007717:Knee / Q000473:pathology; D008297:Male; D009157:Myasthenia Gravis / Q000175:diagnosis*; D009469:Neuromuscular Junction / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D012008:Recurrence; D017678:Sex Distribution