Comparison of propofol with isoflurane for maintenance of anesthesia in patients with chronic obstructive pulmonary disease: use of pulmonary mechanics, peak flow rates, and blood gases.
Patients with chronic obstructive pulmonary disease (COPD) are usually anesthetized with an inhalation agent. After Institutional Review Board approval, informed consent was obtained from 60 patients with moderate to severe COPD according to a preoperative severity scoring system, which took into account history and objective findings. By using objective criteria, such patients were randomly assigned to receive propofol (group I) or isoflurane (group II) as primary maintenance agents. Preoperative and postoperative arterial blood gases, peak expiratory flow rates (PEFR), and chest X-rays were compared. Total dynamic compliance (CDYN) and V1 (% volume exhaled in first second) were measured using Pitot tube sidestream spirometry. A 1,000-mL super-syringe was used to measure total static compliance (CST). Measurements were recorded postintubation, midanesthesia, and pre-extubation. All patients received fentanyl, lidocaine, and propofol, 1.5 to 2.0 mg/kg, for induction. Succinylcholine, 1-1.5 mg/kg, was administered to facilitate intubation. Maintenance was with N2O-O2, vecuronium, and either propofol (n = 30) or isoflurane (n = 30). Both groups showed decreases in postoperative PaO2, SaO2, and PEFR (p < 0.05), but there were no differences between groups (p > 0.05). There were no significant chest X-ray differences. There were no differences between groups with respect to intraoperative pulmonary mechanics (p > 0.05). The only difference between groups was an increase in postoperative PaCO2 in group I and a decrease in group II (p < 0.05). Use of Pitot tube sidestream spirometry is a practical and noninvasive technique for monitoring pulmonary mechanics during anesthesia.(ABSTRACT TRUNCATED AT 250 WORDS)
DeSouza
G
G
Department of Anesthesiology, University of Miami School of Medicine, Fl., USA.
deLisser
E A
EA
Turry
P
P
Gold
M I
MI
D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008170:Lung Compliance / Q000187:drug effects; D008173:Lung Diseases, Obstructive / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010100:Oxygen / Q000097:blood; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology*; D012123:Pulmonary Ventilation / Q000187:drug effects*; D011859:Radiography; D015656:Respiratory Mechanics / Q000187:drug effects*; D013147:Spirometry
D002245:Carbon Dioxide; D007530:Isoflurane; D010100:Oxygen; D015742:Propofol