title: Pleomorphic xanthoastrocytoma with a gangliomatous component: an immunohistochemical and ultrastructural study.
abstract: We report a case of a 24-year-old woman with left temporal pleomorphic xanthoastrocytoma (PXA) with atypical neuronal cells. Many neoplastic cells, otherwise typical of PXA, expressed glial fibrillary acidic protein, while neuronal cells with marked atypia were immunopositive for synaptophysin and neurofilament protein. This report supports a notion that PXA, like other astrocytic tumors, may have its gangliogliomatous counterpart.
authors.affiliation: Department of Pathology, Medical University of Lódź, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Kordek
authors.forename: W
authors.initials: W
authors.lastname: Biernat
authors.forename: W
authors.initials: W
authors.lastname: Sapieja
authors.forename: J
authors.initials: J
authors.lastname: Alwasiak
authors.forename: P P
authors.initials: PP
authors.lastname: Liberski
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000378:metabolism* / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D018303:Ganglioglioma / Q000378:metabolism* / Q000648:ultrastructure; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016900:Neurofilament Proteins / Q000378:metabolism; D009457:Neuroglia / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D016708:Synaptophysin