Effects of cis-dichlorodiammineplatinum on the molecular layer interneurons of the immature rat cerebellum: a putative role for calcium.
The administration of cis-dichlorodiammineplatinum to rats at 10 days of postnatal life (PD 10) alters the immunoreactivity for parvalbumin of the interneurons of the cerebellar molecular layer at late post-treatment intervals. This can result in, but may be also a consequence of the elevation in the cytosolic calcium concentration. Changes in the intracellular calcium homeostasis may induce damage of the cytoskeletal apparatus and impair growth of the cell processes leading to alteration of the ultrastructure of the cell.
Necchi
D
D
Dipartimento di Biologia Animale, Universita' di Pavia, C.N.R., Italy.
Scherini
E
E
Luchini
G
G
Bernocchi
G
G
D000367:Age Factors; D000818:Animals; D002118:Calcium / Q000502:physiology*; D016923:Cell Death; D002531:Cerebellum / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000473:pathology; D006056:Golgi Apparatus / Q000473:pathology; D008854:Microscopy, Electron; D010320:Parvalbumins / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar
D010320:Parvalbumins; D002945:Cisplatin; D002118:Calcium