title: Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXVII. Inhibition of leucocyte adherence to endothelium by the oligoamine RE 1492C and the NO-donor RE 2047.
abstract: The oligoamine RE 1492C (N,N',N"-4-phenylbutyl-1,3,5-benzene-trimethanamine-N,N',N"- triethylcarbamate ) inhibited the electrically provoked leucocyte adhesion to the endothelium of rat mesenteric venoles. An oral dose of 60 mg/kg gave a significant inhibition of 65-78%. This is comparable to effects seen after i.v. administration of iloprost or PGE1, respectively. In the same dosage the NO-donor RE 2047 (3-methyl-N-nitroso-sydnone-5-imine) produced an inhibition of 21-27%.
authors.affiliation: Institut für Pharmazie, Freien Universität Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Rehse
authors.forename: T
authors.initials: T
authors.lastname: Ciborski
authors.forename: B
authors.initials: B
authors.lastname: Müller
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D004558:Electric Stimulation; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D013558:Sydnones / Q000494:pharmacology*
chemical_list: C092610:3-methylsydnone-5-nitrosimine; D010975:Platelet Aggregation Inhibitors; D011073:Polyamines; D013558:Sydnones; C067017:RE 1492