[Comparative study of cefixime versus amoxicillin-clavulanic acid combination in the oral treatment of urinary tract infections in children].
BACKGROUND
Acute febrile infections suggestive of pyelonephritis require treatment by broad-spectrum antibiotics capable of reaching significant tissue levels. This study compares efficacy and safety of cefixime with amoxycillin + clavulanic acid in urinary tract infections.


METHODS
Fifty seven children aged 5 months to 14 years treated for urinary tract infection in ten pediatric centres for a period of 10 months had been randomly included in the study. Thirty (22 girls and eight boys) were given cefixime and 27 (24 girls and three boys) amoxycillin-clavulanate. Efficacy was evaluated in only 36 patients whose bacteria were susceptible to both antibiotics (26 pyelonephritis and ten cystitis).


RESULTS
Sixteen patients out of the 19 given cefixime recovered vs. 14 out of the 17 given amoxycillin-clavulanate with no significant difference between both groups. Bacteria were more often susceptible to cefixime (100% of cases) than to amoxycillin-clavulanate (69%) (p < or = 0.0001). Safety was good and comparable in both groups.


CONCLUSIONS
Cefixime given per os seems effective and safe in treating urinary tract infections. These results have to be confirmed by further studies.
François
P
P
Département de pédiatrie, CHU de Grenoble, France.
Croizé
J
J
Bost
C
C
Wollschlager
K
K
D000284:Administration, Oral; D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002969:Clavulanic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004338:Drug Combinations; D000658:Amoxicillin; D020682:Cefixime; D002439:Cefotaxime
Etude comparant le céfixime à l'association amoxicilline-acide clavulanique dans le traitement par voie orale des infections urinaires de l'enfant.