title: A comparison of human exposures to fiberglass with those used in a recent rat chronic inhalation study.
abstract: In a recent rat inhalation study, 2 years of exposure to high concentrations of fiberglass (FG) resulted in no treatment-related fibrosis or thoracic tumors. To determine the relevancy of this study for human risk assessment, it is important to compare the rat experimental exposure levels with those of humans. Data on human exposures were taken from several studies and included FG manufacturing, installation and removal, and ambient air. FG levels in the rat aerosol were 200,000-fold higher than indoor air, > 2000-fold higher than during FG insulation manufacturing, and > 1000-fold higher than FG batt installation. The rat aerosol was 30-fold more concentrated than the highest human exposure (blowing installation of unbound FG). Rat FG lung burden also vastly exceeded that of FG workers, which was not significantly elevated above nonworker levels. The amount of fibers/mg dry lung for the rat after lifetime exposure was > 4000-fold greater than for the FG worker, average exposure 11 years. Aerosol and lung fiber dimensions in the rat study were comparable to those of human exposures. From these comparisons, it can be concluded that the exposure level in the rat inhalation study was sufficiently, if not excessively, high in comparison to human exposures. Increasing the experimental exposure in the rat studies would not serve to mirror human environmental or occupational exposures.
authors.affiliation: Mountain Technical Center, A Division of Schuller International, Littleton, Colorado 80127, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Hesterberg
authors.forename: G A
authors.initials: GA
authors.lastname: Hart
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000393:Air Pollutants / Q000032:analysis; D000395:Air Pollutants, Occupational / Q000032:analysis; D000818:Animals; D001822:Body Burden; D005898:Glass; D006801:Humans; D008168:Lung / Q000473:pathology; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D051381:Rats; D018570:Risk Assessment
chemical_list: D000336:Aerosols; D000393:Air Pollutants; D000395:Air Pollutants, Occupational; C009753:fiberglass