Dysfunctional activation of subcortical nuclei in palatal myoclonus detected by high-resolution MRI.
Magnetic resonance images that were sensitized to changes in cerebral blood oxygenation state demonstrated dysfunctional activation of the dentate nuclei, the left inferior olivary nucleus and the left red nucleus in a 56-year-old patient with palatal myoclonus. These findings represent the first demonstration of movement-related activation of cerebellar, brainstem and midbrain nuclei in a single subject and at a spatial resolution comparable to that of anatomic MR images.
Boecker
H
H
Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.
Kleinschmidt
A
A
Weindl
A
A
Conrad
B
B
Hänicke
W
W
Frahm
J
J
D001933:Brain Stem / Q000033:anatomy & histology / Q000503:physiopathology; D002529:Cerebellar Nuclei / Q000033:anatomy & histology* / Q000503:physiopathology*; D002531:Cerebellum / Q000033:anatomy & histology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000033:anatomy & histology / Q000503:physiopathology; D008875:Middle Aged; D009207:Myoclonus / Q000175:diagnosis* / Q000503:physiopathology*; D010156:Palatal Muscles