title: [A case of acute lupus pneumonitis].
abstract: Forty-five-year-old woman with systemic lupus erythematosus who had treated with sulindac had exacerbation of her rash and arthralgia. On her admission for treatment, chest X-ray showed bilateral pathy infiltrates in lower lung fields. We performed a transbronchial lung biopsy. Immunohistopathologic studies showed granular deposits of IgM and C 3 in the subendothelial area of pulmonary arteriolae. She was treated with prednisolone (1.0 mg/kg/day) and deoxyspergualin. Chest X-ray showed improvement and her serum IgG, anti-DNA antibodies and complement diminished quickly. We suggest that these immunopathologic observations may be important in the pathogenesis of the lung injury in systemic lupus erythematosus.
authors.affiliation: Department of internal medicine, Kitami Red Cross Hospital, Hokkaido.
authors.forename: T
authors.initials: T
authors.lastname: Saeki
authors.forename: K
authors.initials: K
authors.lastname: Taneichi
authors.forename: H
authors.initials: H
authors.lastname: Shibaki
mesh_terms: D000208:Acute Disease; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D011014:Pneumonia / Q000209:etiology*
chemical_list: D003176:Complement C3; D007075:Immunoglobulin M