Fluconazole penetration into the human prostate.
Fluconazole concentrations in the serum and prostate of human volunteers undergoing transurethral resection for benign prostatic hypertrophy were measured. There was a high correlation (r = 0.783) between serum (mean = 6.6 micrograms/ml) and tissue (mean = 1.9 micrograms/g) fluconazole concentrations, and these data were used to construct a model for local tissue concentrations.
Finley
R W
RW
Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA.
Cleary
J D
JD
Goolsby
J
J
Chapman
S W
SW
D003453:Cryptococcosis / Q000188:drug therapy; D015725:Fluconazole / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism*
D015725:Fluconazole