Effects of a low sodium diet with a high potassium content on plasma endothelin-1, atrial natriuretic peptide and arginine vasopressin in normal dogs.
Eight clinically healthy male beagle dogs received a low sodium diet for 5 weeks. Before and after this period the dogs received a control diet for 3 weeks. Both diets provided the dogs with approximately 6.8 mmol K+/kg/day. Neither introducing nor withdrawing the low sodium diet changed the plasma concentrations of endothelin-1 (ET-1), atrial natriuretic peptide (ANP) and arginine vasopressin (AVP). Pooled data from the control periods were not different from the low sodium period for either ET-1 (2.31 pg/ml and 2.09 pg/ml, P = 0.21), ANP (42.51 pg/ml and 38.99 pg/ml, P = 0.44) or AVP (4.14 pg/ml and 4.16 pg/ml, P = 0.91). It was concluded that ET-1, ANP and AVP in normal dogs are unaffected by a 6-fold change in sodium intake in the presence of a high potassium intake.
Pedersen
H D
HD
Clinical Department, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Koch
J
J
Bie
P
P
Jensen
A L
AL
Flagstad
A
A
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004039:Diet, Sodium-Restricted / Q000662:veterinary*; D004285:Dogs / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000097:blood*; D008297:Male; D017419:Potassium, Dietary / Q000008:administration & dosage / Q000494:pharmacology*
D016232:Endothelins; D017419:Potassium, Dietary; D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor