title: [Chemotherapeutic effectiveness of pefloxacin in experimental infections].
abstract: High efficacy of pefloxacin was shown in its study on albino mice with experimental infections such as sepsis, pneumonia and peritonitis. In the effective doses administered orally the drug rapidly arrested the clinical signs of the diseases and provided the sanation of the organs and tissues. The broad antibacterial spectrum of pefloxacin substantiated its efficacy in the treatment of purulent septic processes due to gram-negative and gram-positive pathogens, as well as in the treatment of mixed infections. It is a drug with prolonged action which was confirmed with its prophylactic use. Pefloxacin was efficient in the treatment of infections of various severity.
authors.forename: A N
authors.initials: AN
authors.lastname: Lobuseva
authors.forename: S M
authors.initials: SM
authors.lastname: Iudin
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D051379:Mice; D015366:Pefloxacin / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy*; D011014:Pneumonia / Q000188:drug therapy*; D018805:Sepsis / Q000188:drug therapy*
chemical_list: D015366:Pefloxacin
vernacular_title: Khimioterapevticheskaia éffektivnost' pefloksatsina pri éksperimental'nykh infektsiiakh.