title: Modulation of cochlear responses in the guinea pig by low-frequency, phase-shifted maskers following noise trauma.
abstract: Low-frequency acoustic biasing using an intensive phase-shifted, low-frequency masker was studied according to its ability to determine disorders of cochlear micromechanics following noise trauma in the guinea pig as animal model. Statistical analyses proved that this technique allowed electrophysiological differentiation of controls versus groups with different degrees of experimentally induced threshold shifts. To substantiate group differences an intensity of at least 70 dB SPL was required for the 52 Hz masker and the difference in relation to the test-tone intensity had to be +/- 10 or +/- 20 dB SPL. The noise-traumatized cochlea could be identified by means of a threshold shift for the 5 microV pseudothreshold, a low modulation span of the compound action potential amplitude (< 25-50 microV frequency dependent), and reduced positive summating potential amplitude with negative non-modulating values within the different measurement phases for 1 and 2 kHz stimulation.
authors.affiliation: Department of Otolaryngology, University of Würzburg, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Hoehmann
authors.forename: S
authors.initials: S
authors.lastname: Müller
authors.forename: J L
authors.initials: JL
authors.lastname: Dornhoffer
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000502:physiology*; D003051:Cochlea / Q000503:physiopathology*; D015834:Cochlear Diseases / Q000209:etiology* / Q000503:physiopathology*; D003055:Cochlear Microphonic Potentials / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009622:Noise / Q000009:adverse effects*; D009925:Organ of Corti / Q000503:physiopathology; D011930:Reaction Time; D012405:Round Window, Ear / Q000503:physiopathology