[Comparative assessment of digoxin and captopril in the treatment of chronic congestive circulatory failure, NYHA grade II].
In 42 patients aged 33 to 79 years (mean age 55 years) with NYHA grade II chronic congestive circulatory failure, a comparative assessment was carried out of the effectiveness of treatment with captopril (29 patients, daily dose 18.75-150 mg, mean 82.5 mg) adn digoxin (13 patients, daily dose 0.125-0.5 mg, mean 0.275 mg). The patients were administered the drugs, depending on the improvement obtained, for 3-5 weeks. In the assessment of the effectiveness of the treatment, the following was taken into account: medical examination, laboratory investigations, chest X-ray, exercise tests and haemodynamic parameters measured during 2D and M echocardiographic examination. In the group of patients treated with digoxin the following was observed: a significant, in comparison to the patients receiving captopril, reduction of the heart rate by 11 beats per minute, decrease of the heart volume index by 50 ml/m2 and increase of the stroke volume by 14 ml. Higher effectiveness of captopril was observed as increase of the maximal workload during exercise test by 21 W and prolongation of its duration by three minutes. It seems that captopril may find use also in the treatment of early stages of circulatory failure.
Lehmann
Z
Z
II Kliniki Kardiologii Instytutu Kardiologii Ak. Med. im. K. Marcinkowskiego, Poznaniu.
Wierzchowiecki
M
M
Michalski
M
M
Stasiński
T
T
Ozegowski
S
S
D000328:Adult; D000368:Aged; D002216:Captopril / Q000627:therapeutic use*; D002908:Chronic Disease; D004077:Digoxin / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D004077:Digoxin; D002216:Captopril
Ocena porównawcza digoksyny i kaptoprylu w leczeniu przewlekłej zastoinowej niewydolności krazenia II stopnia wg NYHA.