Pharmacokinetics of ofloxacin through three administration routes.
This paper reports the pharmacokinetic characteristics of ofloxacin (Ofl) through 3 administration routes in 42 patients with respiratory tract infections. The concentration-time data were fitted with a two-compartment model for infusion (inf) and im, and a one-compartment model for po. The pharmacokinetic parameters of Ofl through inf, im and po were: T1/2 beta or T1/2K 6.0 +/- 1.3, 5.0 +/- 1.0, and 5.0 +/- 0.7 h; Vc or Vd 58 +/- 16, 68 +/- 27 and 94 +/- 25 L; Cmax 3.9 +/- 1.0, 2.8 +/- 0.9, and 1.9 +/- 0.7 micrograms.ml-1; AUC 16 +/- 5, 15 +/- 4, and 15 +/- 4 h.micrograms.ml-1; Cl 13 +/- 4, 14 +/- 4, and 14 +/- 3 L.h-1, respectively.
Zhuo
H T
HT
Department of Clinical Pharmacology, Jinling Hospital, Nanjing, China.
Lu
J Z
JZ
Xia
X R
XR
Ling
S S
SS
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012141:Respiratory Tract Infections / Q000378:metabolism
D015242:Ofloxacin