title: HLA-linked hemochromatosis and other forms of iron overload.
abstract: Inherited forms of iron overload are common. HLA-linked hemochromatosis and possibly African iron overload are associated with a significant risk of developing hepatocellular carcinoma. Early diagnosis and treatment, before substantial iron overloading occurs, reduces morbidity and mortality. HLA-linked hemochromatosis is easily diagnosed, and routine screening in European-derived populations may be appropriate.
authors.affiliation: Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa.
authors.forename: P D
authors.initials: PD
authors.lastname: Bloom
authors.forename: V R
authors.initials: VR
authors.lastname: Gordeuk
authors.forename: A P
authors.initials: AP
authors.lastname: MacPhail
mesh_terms: D000349:Africa; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D005060:Europe; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006432:Hemochromatosis / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D011230:Precancerous Conditions / Q000473:pathology*
chemical_list: D006680:HLA Antigens; D007501:Iron