The kinase insert domain receptor gene (KDR) has been relocated to chromosome 4q11-->q12.
Through in situ hybridization of a genomic DNA probe to metaphase chromosomes, we have localized the KDR gene to 4q11-->q12. This is the same locus as that for two other receptor tyrosine kinases, PDGFRA and KIT. This location for KDR differs from that which we previously reported using a cDNA probe. Using cDNA probes for both KDR and KIT identifies a locus at 4q31-->q32 which may uncover another cluster of receptor tyrosine kinase genes.
Sait
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Department of Human Genetics, Roswell Park Cancer Institute, Buffalo NY.
Dougher-Vermazen
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Shows
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Terman
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BI
D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D008856:Microscopy, Fluorescence; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D017978:Receptors, Growth Factor / Q000235:genetics*; D040262:Receptors, Vascular Endothelial Growth Factor
D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor