Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats.
The cellular source of interleukin-6 (IL-6) in brain has not been identified. Using a sensitive, non-radioactive in situ hybridization technique, the cellular localization of IL-6 mRNA in different areas of the rat brain was analysed. Intense staining for IL-6 mRNA was found in Purkinje cells and hippocampal neurons. Our data support an essential role of IL-6 for cerebellar and hippocampal neuron differentiation and function.
Gadient
R A
RA
Department of Physiology, University of Basel, Switzerland.
Otten
U
U
D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D015870:Gene Expression; D006624:Hippocampus / Q000502:physiology*; D017403:In Situ Hybridization; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D009474:Neurons / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats
D015850:Interleukin-6; D012333:RNA, Messenger