title: Angiotensin modulation of vascular tone and adrenergic neurotransmission in cat femoral arteries.
abstract: 1. AI and AII induced contractions in cat femoral arteries, which were inhibited by saralasin. 2. The response to AI was reduced by captopril and endothelium removal and by chymostatin in endothelium-denuded segments. 3. AII contractions were increased by indomethacin, L-NAME and endothelium removal. 4. AII and AI facilitated the adrenergic neurotransmission. This facilitation was inhibited by saralasin and/or captopril. 5. These data suggest: (1) AI is converted into AII in the endothelial and adventitial layer; (2) the contractions caused by AI and AII are mediated by AII receptors and are modulated by endothelial release of NO and PGI2; and (3) the existence of presynaptic AII receptors mediating the facilitation of neurotransmission caused by AI and AII.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Encabo
authors.forename: M
authors.initials: M
authors.lastname: Ferrer
authors.forename: J
authors.initials: J
authors.lastname: Marín
authors.forename: G
authors.initials: G
authors.lastname: Balfagón
mesh_terms: D000704:Analysis of Variance; D000803:Angiotensin I / Q000378:metabolism*; D000804:Angiotensin II / Q000096:biosynthesis / Q000502:physiology*; D000818:Animals; D002415:Cats; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D005263:Femoral Artery / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*
chemical_list: D000804:Angiotensin II; D000803:Angiotensin I; D009638:Norepinephrine