title: Deep cerebral venous thrombosis and hereditary tissue plasminogen activator (t-PA) deficiency.
abstract: We describe a patient with defective tissue plasminogen activator (t-PA) release who developed internal cerebral vein thrombosis. She recovered completely and, as shown by MRI, favourable outcome was probably related to vascular recanalisation. Other members of the pedigree had a similar fibrinolytic deficiency without clinical manifestations. The use of oral contraceptives may have contributed to the patient's hypercoagulable state.
authors.affiliation: Divisione di Neurologia, Ospedale Maggiore.
authors.forename: F
authors.initials: F
authors.lastname: Tezzon
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: V
authors.initials: V
authors.lastname: Sbarbaro
authors.forename: A
authors.initials: A
authors.lastname: Beltramello
authors.forename: P L
authors.initials: PL
authors.lastname: Arigliano
authors.forename: M
authors.initials: M
authors.lastname: Negri
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D003328:Coronary Thrombosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010375:Pedigree; D013924:Thrombophlebitis / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D010959:Tissue Plasminogen Activator / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D003278:Contraceptives, Oral, Hormonal; D010959:Tissue Plasminogen Activator