title: Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXVIII: Oligoamines with fluorescent properties. Part C: Fluorescent oligoamines with enhanced hydrophilic properties.
abstract: Fifteen fluorescent oligoamines with one or two fluorescent groups and two or three basic N-functions were prepared and tested for antiplatelet activity (Born-test). Five compounds involving three different fluorophores, i.e. 2-fluorenyl, 1-pyrenyl, and 9-phenanthryl, show an IC50 of 7-11 mumol/L. They are suitable to serve as probes in the field of oligoamine-biopolymere interactions.
authors.affiliation: Institut für Pharmazie, Freien Universität Berlin, Dahlem.
authors.forename: K
authors.initials: K
authors.lastname: Rehse
authors.forename: T
authors.initials: T
authors.lastname: Seidel
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000588:Amines; D005456:Fluorescent Dyes; D010975:Platelet Aggregation Inhibitors