title: Transient regression in lymphocyte count in B-cell chronic lymphocytic leukemia after viral infection.
abstract: Transient regression in the lymphocyte count of a patient with B-cell chronic lymphocytic leukemia (B-CLL) after viral infection is reported. A similar event occurred under natural interferon-alpha (IFN-alpha) treatment. It was confirmed that the event was not caused by a direct cytotoxic effect of IFN-alpha by analyzing the DNA fragmentation to estimate apoptotic and necrotic cell death before and after the administration of IFN-alpha. The study also suggested that the event was not caused by a cytostatic effect of IFN-alpha.
authors.affiliation: Division of Clinical Hematology and Immunology, Kumamoto City Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shirono
authors.forename: M
authors.initials: M
authors.lastname: Ikebe
authors.forename: T
authors.initials: T
authors.lastname: Inada
authors.forename: H
authors.initials: H
authors.lastname: Tsuda
mesh_terms: D000328:Adult; D017209:Apoptosis; D001402:B-Lymphocytes; D004247:DNA / Q000097:blood; D006560:Herpes Labialis / Q000097:blood*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000628:therapy / Q000821:virology; D018655:Lymphocyte Count; D008297:Male; D009336:Necrosis / Q000097:blood; D012074:Remission Induction
chemical_list: D016898:Interferon-alpha; D004247:DNA