[Biochemical and ultrastructural changes in the periodontium during the chronic administration of pro-oxidant xenobiotics].
Effects of chronic administration of xenobiotics pro-oxidants on the state of periodontal tissues, level of free-radical oxidation of lipids, and antioxidant provision were studied. Diphenin and delagil were found to promote biochemical and morphological changes similar to the manifestations observed in periodontitis. A conclusion is made about an important role of nonenzymatic free-radical oxidation of lipids and biopolymers in the pathogenesis of periodontitis. The principal stages of contribution of autooxidation to the parodontogenesis are presented.
Bobyrev
V N
VN
Kovalev
E V
EV
Rozkolupa
N V
NV
Eremina
N F
NF
Voskresenskiĭ
O N
ON
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000494:pharmacology; D002738:Chloroquine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008854:Microscopy, Electron; D010519:Periodontium / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D010672:Phenytoin / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D010672:Phenytoin; C023676:chloroquine diphosphate; D002738:Chloroquine
Biokhimicheskie i ul'trastrukturnye izmeneniia v parodonte pri khronicheskom vvedenii ksenobiotikov-prooksidantov.