Influence of salt loading on the cardiac and renal preproendothelin-1 mRNA expression in stroke-prone spontaneously hypertensive rats.
Endothelin-1 is a potent vasoactive peptide which may play a role in the regulation of vascular resistance through its autocrine/paracrine effects. We have investigated the influence of salt loading on the renal and cardiac production of endothelin-1 in stroke prone spontaneously hypertensive rats, a classical model of hypertension. The results show that the dietary salt intake did not change systolic blood pressure nor the renal expression of the preproendothelin-1 mRNA but increased cardiac expression of the endothelin-1 gene transcript and a concomitant ventricular hypertrophy.
Feron
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O
Laboratoire de Pharmacologie, Université Catholique de Louvain, UCL 5410, Brussels, Belgium.
Salomone
S
S
Godfraind
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T
D000818:Animals; D015152:Blotting, Northern; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000378:metabolism*; D019332:Endothelin-1; D016232:Endothelins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006321:Heart / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*
D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors; D012333:RNA, Messenger; D012965:Sodium Chloride