Effects of a non-xanthine adenosine antagonist, CGS 15943, and a phosphodiesterase inhibitor, Ro 20-1724, in a light/dark test in mice.
We investigated the effects of a non-xanthine adenosine receptor antagonist, CGS 15943, and a non-xanthine phosphodiesterase inhibitor, Ro 20-1724, in a light/dark test in mice. CGS 15943 at a dose of 50 mg/kg had no significant effects on any parameter, although at 10 mg/kg it significantly antagonized decreases in locomotion and rearing behavior induced by treatment with A1 and A2 selective agonists, N6-cyclopentyladenosine and CGS 21680 respectively. On the other hand, Ro 20-1724 decreased locomotion and rearing behavior in the light and dark zones, number of shuttle crosses between both zones, and the time spent in the light zone dose-dependently at doses ranging from 1-10 mg/kg. In conclusion, the phosphodiesterase inhibitor decreased all parameters in the light/dark test, while the adenosine antagonist showed no effect.
Imaizumi
M
M
Biology Laboratory, Yamasa Corporation, Choshi, Japan.
Miyazaki
S
S
Onodera
K
K
D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / Q000494:pharmacology*; D000241:Adenosine / Q000037:antagonists & inhibitors*; D000818:Animals; D001007:Anxiety / Q000523:psychology; D003624:Darkness; D008027:Light; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D011799:Quinazolines; D014230:Triazoles; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; D000241:Adenosine; C052410:9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine