In vitro study of cytotoxic activity of vinblastine in a free form and associated with nanoparticles.
The cytotoxic activities of unloaded polybutylcyanoacrylate nanoparticles (PBCN), free vinblastine, vinblastine-loaded nanoparticles (by incorporation and adsorption processes) and a mixture of vinblastine-free and unloaded PBCN were compared in vitro on human erythroleukemic K-562 cells. Enhanced cytotoxicity was observed when vinblastine was either adsorbed on PBCN or mixed with them rather than free. When vinblastine was incorporated into polymer matrix of nanoparticles, a lag period and postponed cytotoxic effect on K-562 cells were observed.
Simeonova
M
M
Scientific Research Centre for Speciality Polymers, Sofia, Bulgaria.
Antcheva
M
M
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004659:Enbucrilate; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy; D008863:Microspheres; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000008:administration & dosage / Q000494:pharmacology*
D000970:Antineoplastic Agents; D014747:Vinblastine; D004659:Enbucrilate