[Biokinetics of tumor-affinity yttrium preparations--Part 1].
Differences of yttrium biokinetics after application to male tumor-bearing mice of 87Y-citrate were studied in comparison to a 87Y-NTA-EDTMP-Ca mixture after variation of both the manner of application (intraperitoneal vs. intratumoral) and the tumor type (mamma carcinoma vs. melanoma). The application of 87Y as NTA-EDTMP-Ca preparation led--in comparison to the citrate form applied so far--to a similar radionuclide tumor accumulation and distinctly lower extratumoral radioactivities in liver, spleen and skeleton with clearly more favorable tumor/background ratios. Melanomas showed a significantly higher radioactivity accumulation (factor 2-3) after injection of 87Y-NTA-EDTMP-Ca than mamma carcinomas. Intratumoral application led to high initial radioactivities in the tumors. Radioactivity concentrations which are comparable with those after intraperitoneal application were achieved within 4 h after intratumoral application. The application of the EDTMP-containing mixture promises in comparison to the traditional citrate form higher radiation doses in the tumor related to the whole-body radiation exposure. The consequences for a possible tumor therapy will be further investigated.
Schomäker
K
K
Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln.
Hientzsch
B
B
Franke
W G
WG
Scheidhauer
K
K
Scharl
A
A
Jantsch
K
K
Shukla
S K
SK
Limouris
G
G
Schicha
H
H
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002951:Citrates / Q000493:pharmacokinetics; D007700:Kinetics; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D014018:Tissue Distribution; D015021:Yttrium Radioisotopes / Q000493:pharmacokinetics*
D002951:Citrates; D009942:Organometallic Compounds; D015021:Yttrium Radioisotopes; C045937:yttrium citrate; D002118:Calcium
Untersuchungen zur Biokinetik tumoraffiner Yttrium-Zubereitungen--1. Teil.