A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia.
We have used a homology based approach to identify G protein-coupled receptors preferentially expressed in retinal and taste cells. Rat and bovine sequences encoding a novel G protein-coupled receptor have been isolated. Analysis indicates that while the protein sequence is most similar to the receptors for somatostatin and opiates, it is unlikely to be a subtype of these receptors. Northern and RNase protection analysis indicates that the gene is preferentially expressed in neural and sensory tissues.
Tal
M
M
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Ammar
D A
DA
Karpuj
M
M
Krizhanovsky
V
V
Naim
M
M
Thompson
D A
DA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D019204:GTP-Binding Proteins / Q000502:physiology; D015870:Gene Expression; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018013:Receptors, Neuropeptide / Q000235:genetics*; D012160:Retina; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D013649:Taste / Q000502:physiology*; D013650:Taste Buds / Q000737:chemistry; D014059:Tongue / Q000737:chemistry*
D012333:RNA, Messenger; D018013:Receptors, Neuropeptide; D019204:GTP-Binding Proteins