[The effects of Salvia miltiorrhizae Bge and Ligustrazine on thromboxane A2 and prostacyclin in pregnancy induced hypertension].
The clinical efficiency and mechanism of traditional Chinese medicinal herb Salvia Miltiorrhizae Bge (SMB) and Ligustrazine (L) on pregnancy induced hypertension (PIH) were studied in 30 patients. Before and after the administration of SMB and L, the following parameters: mean arterial pressure (MAP), proteinuria, levels of Thromboxane A2 (TXA2) and Prostacyclin (PGI2) were observed. TXA2 and PGI2 were measured by their stable hydration products Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) by an established radioimmunoassay. The results of treatment were compared with the base line values and showed as follows: MAP and proteinuria decreased significantly (P < 0.05); no marked difference existed in TXB2; the level of 6-keto-PGF1 alpha increased significantly (P < 0.05); the rate of TXB2/6-keto-PGF1 alpha decreased significantly (P < 0.05). The results suggested that SMB and L can invigorate blood circulation by decreasing vasoconstriction.
Liu
S Y
SY
Affiliated Hospital of Binzhou Medical College.
Xu
Y Y
YY
Zhu
J Y
JY
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D010936:Plant Extracts; D011225:Pre-Eclampsia / Q000097:blood / Q000188:drug therapy*; D011247:Pregnancy; D011719:Pyrazines / Q000627:therapeutic use*; D027561:Salvia miltiorrhiza; D013928:Thromboxane A2 / Q000097:blood*
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D011719:Pyrazines; D013928:Thromboxane A2; D011464:Epoprostenol; C017953:tetramethylpyrazine