Isolation and structure determination of a new marine neurotoxin from the New Zealand shellfish, Austrovenus stutchburyi.
A new marine neurotoxin was isolated from a water extract of the New Zealand shellfish, Austrovenus stutchburyi, by chromatography on columns of Sephadex G-15 and LH-20, followed by reverse-phase HPLC. It was identified as (4-methoxycarbonylbutyl)trimethyl-ammonium chloride, and this was confirmed by synthesis.
Ishida
H
H
School of Pharmaceutical Science, University of Shizuoka, Japan.
Nozawa
A
A
Nukaya
H
H
Tsuji
K
K
Kaspar
H
H
Berkett
N
N
Kosuge
T
T
D000818:Animals; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D009498:Neurotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D009520:New Zealand; D012758:Shellfish; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D008387:Marine Toxins; D009498:Neurotoxins