title: Significance of high levels of serum IgA and IgA-class circulating immune complexes (IgA-CIC) in patients with non-insulin-dependent diabetes mellitus.
abstract: Significance of serum IgA and IgA-class circulating immune complexes (IgA-CIC) elevation in patients with non-insulin-dependent diabetes mellitus (NIDDM) was described. Seventeen patients with NIDDM and 17 patients with diffuse mesangial proliferative glomerulonephritis without deposition of IgA (DPGN) as controls were examined. The levels of serum IgA in patients with NIDDM were significantly higher than those in patients with DPGN (p < or = 0.01). The levels of IgA-CIC in patients with NIDDM were also significantly higher than those in patients with DPGN (p < or = 0.01). Production of IgA derived from B cells and the proportion of IgA bearing B cells in patients with NIDDM were not significantly higher than those in patients with DPGN. Furthermore, the levels of IgA in pharyngeal washings from diabetic patients were not significantly higher than those for DPGN patients. Duration of diabetes, the level of HbA1c, and the presence of hypertension, microalbuminuria, or retinopathy showed no significant correlations with the levels of serum IgA or IgA-CIC in patients with NIDDM. It was postulated that the elevations of serum IgA and IgA-CIC were based on subclinical infection of the mucosa and/or deterioration of IgA clearance in patients with NIDDM.
authors.affiliation: Division of Metabolism and Nephrology, School of Medicine, Tokai University, Isehara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: M
authors.initials: M
authors.lastname: Yagame
authors.forename: D
authors.initials: D
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Jinde
authors.forename: R
authors.initials: R
authors.lastname: Naka
authors.forename: N
authors.initials: N
authors.lastname: Yano
authors.forename: Y
authors.initials: Y
authors.lastname: Nomoto
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000097:blood*; D001402:B-Lymphocytes / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000276:immunology*; D005921:Glomerulonephritis / Q000097:blood / Q000276:immunology; D006801:Humans; D007154:Immune System Diseases / Q000097:blood / Q000276:immunology; D007070:Immunoglobulin A / Q000097:blood*; D008213:Lymphocyte Activation; D008875:Middle Aged; D010614:Pharynx / Q000276:immunology; D011043:Pokeweed Mitogens; D011237:Predictive Value of Tests
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D011043:Pokeweed Mitogens