New oral dosage form for elderly patients: preparation and characterization of silk fibroin gel.
The pharmaceutical utility of silk fibroin as a possible material for an oral dosage form for elderly patients was investigated. Silk fibroin gel (SFG) was prepared from its aqueous solution. The gel formation was studied as a function of adjusted pH and concentration of silk fibroin (SF). On the basis of Fourier transform infrared spectroscopy of SFG, the transition from the random coil to the beta-structure was observed. The rate of gelation was sufficiently accelerated by the addition of glycerol to the SF aqueous solution. The glycerol content also affected the rate of gelation of the SF solution. Rheological properties of SFG were evaluated using a creep meter. The SF content and/or glycerol content affected the breaking stress of SFG. Moisture desorption from SFG was retarded with an increase in glycerol content. It was found that SFG was able to be prepared at room temperature (20 +/- 5 degrees C), and the SF content and glycerol content affected the formation and physicochemical properties of SFG.
Hanawa
T
T
Pharmaceutical Department, Tokyo Women's Medical College, Japan.
Watanabe
A
A
Tsuchiya
T
T
Ikoma
R
R
Hidaka
M
M
Sugihara
M
M
D000284:Administration, Oral; D000368:Aged; D001672:Biocompatible Materials / Q000592:standards*; D004304:Dosage Forms; D005349:Fibroins / Q000737:chemistry* / Q000592:standards / Q000627:therapeutic use; D005782:Gels / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019476:Insect Proteins; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D012212:Rheology; D047011:Silk; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013784:Textiles
D001672:Biocompatible Materials; D004304:Dosage Forms; D005782:Gels; D019476:Insect Proteins; D011506:Proteins; D047011:Silk; D005349:Fibroins; D005990:Glycerol