title: [Comparative in vitro activity ampicillin, cefoperazone, their combinations with sulbactam, as well as that of other antibiotics against aerobic gram-negative microorganisms].
abstract: The activity of 12 antibiotics against 849 strains of gram-negative aerobes isolated in special and general hospitals of Moscow and Smolensk in 1992-1993 was assayed with the method of serial microdilutions. By the criteria of the activity (percentage of the susceptible strains by the NSSLS criteria) against the isolates the antibiotics were arranged as follows: ciprofloxacin (89.8 per cent) > imipenem (89.6 per cent) > cefoperazone + sulbactam (86.1 per cent) > amikacin (83.8 per cent) > ceftazidime (81.8 per cent) > ceftriaxone (71.1 per cent) > cefoperazone (70.9 per cent) > cefotaxime (70.9 per cent) > gentamicin (60.8 per cent) > ampicillin + sulbactam (44.7 per cent) > cefazolin (37.5 per cent) > ampicillin (23.0 per cent). The frequency of the antibiotic susceptible isolates in the special hospitals was lower at the average by 20 per cent than that in the general hospitals with respect to all the antibiotics assayed.
authors.forename: S V
authors.initials: SV
authors.lastname: Sidorenko
authors.forename: S P
authors.initials: SP
authors.lastname: Rezvan
authors.forename: O N
authors.initials: ON
authors.lastname: Speranskaia
authors.forename: L A
authors.initials: LA
authors.lastname: Krotova
authors.forename: A S
authors.initials: AS
authors.lastname: Tikhonova
authors.forename: L S
authors.initials: LS
authors.lastname: Strachunskiĭ
authors.forename: S M
authors.initials: SM
authors.lastname: Navashin
authors.forename: S E
authors.initials: SE
authors.lastname: Kuleshov
authors.forename: S V
authors.initials: SV
authors.lastname: Budanov
authors.forename: L E
authors.initials: LE
authors.lastname: Ansolis
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002438:Cefoperazone / Q000494:pharmacology*; D004338:Drug Combinations; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D000667:Ampicillin; D002438:Cefoperazone
vernacular_title: Sravnitel'naia aktivnost' in vitro ampitsillina, tsefoperazona, ikh kombinatsiĭ s sul'baktamom, a takzhe drugikh antibiotikov v otnoshenii aérobnykh gramotritsatel'nykh mikroorganizmov.