Delayed hypersensitivity to one low-molecular-weight heparin with tolerance of other low-molecular-weight heparins.
We report a patient who developed infiltrated plaques at the sites of subcutaneous injection of a low-molecular-weight heparin. Skin tests and a lymphocyte transformation test revealed hypersensitivity to sandoparin and heparin sodium. The low-molecular-weight heparins nadroparin and dalteparin were subsequently tolerated without adverse effects. Possible risk factors for sensitization are discussed.
Bircher
A J
AJ
Department of Dermatology, University Hospital, Basle, Switzerland.
Itin
P H
PH
Tsakiris
D A
DA
Surber
C
C
D004342:Drug Hypersensitivity; D004361:Drug Tolerance; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D008213:Lymphocyte Activation; D008875:Middle Aged; D012882:Skin Tests; D014647:Varicose Ulcer / Q000188:drug therapy
D006495:Heparin, Low-Molecular-Weight