Perfusional and metabolic effects of nisoldipine as shown by positron emission tomography after acute myocardial infarction.
After myocardial infarction, regional dysfunction can occur in viable myocardial regions because of the presence of baseline hypoperfusion. Recent evidence suggests that these areas may maintain a residual perfusion reserve. The aim of the present study was to evaluate whether oral nisoldipine can increase regional myocardial blood flow (MBF) in dyssynergic but viable myocardium after myocardial infarction. Patients with isolated left anterior descending coronary stenosis were studied 1 month after the first myocardial infarction. Patients underwent [18F]fluorodeoxyglucose imaging, and MBF was measured, using positron emission tomography and [13N]ammonia, at baseline and following dobutamine administration (10 micrograms/kg/min over 5 minutes). MBF measurements were repeated 24 hours after nisoldipine (10 mg twice daily). Preliminary results suggest that necrotic areas showed the largest reduction in baseline MBF. Dyssynergic-viable regions showed a reduced resting MBF but maintained a residual perfusion reserve in response to inotropic stimulation. Thus, nisoldipine selectively improved basal perfusion in dyssynergic-viable myocardium.
Brunelli
C
C
Department of Cardiology, University of Genova, Italy.
Parodi
O
O
Sambuceti
G
G
Corsiglia
L
L
Rosa
G M
GM
Giorgetti
A
A
Bezante
G P
GP
Nista
N
N
Caponnetto
S
S
D000328:Adult; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D004280:Dobutamine; D004452:Echocardiography / Q000379:methods; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D015737:Nisoldipine / Q000494:pharmacology / Q000627:therapeutic use*; D014055:Tomography, Emission-Computed; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy / Q000209:etiology
D004280:Dobutamine; D015737:Nisoldipine