title: Prenatal diagnosis of fetal disseminated intravascular coagulation associated with umbilical cord arteriovenous malformation.
abstract: BACKGROUND
  Congenital disseminated intravascular coagulation (DIC) has been reported in a variety of clinical settings, but to our knowledge, it has never been documented before birth. We describe prenatal identification of an umbilical cord vascular tumor and echogenic foci in the fetal liver leading to the diagnosis of fetal DIC by funipuncture.
  
  
  METHODS
  A large vascular tumor of the umbilical cord was identified using prenatal sonography. At 31 weeks' gestation, echogenic areas, which were thought to represent infarcts or thrombi, were seen in the liver. When funipuncture revealed florid fetal DIC, delivery was accomplished by cesarean to prevent intracranial bleeding. Pathologic examination of the umbilical cord tumor showed it to be a large arteriovenous malformation.
  
  
  CONCLUSIONS
  Arteriovenous malformations may cause fetal coagulopathy. This case illustrates that funipuncture may be used to diagnose this condition and that timely cesarean delivery may contribute to a favorable outcome.
authors.affiliation: Division of Maternal Fetal Medicine, University of Florida College of Medicine, Gainesville, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Richards
authors.forename: E
authors.initials: E
authors.lastname: Lutfi
authors.forename: D
authors.initials: D
authors.lastname: Mullins
authors.forename: D L
authors.initials: DL
authors.lastname: Sandler
authors.forename: B D
authors.initials: BD
authors.lastname: Raynor
mesh_terms: D000328:Adult; D001165:Arteriovenous Malformations / Q000150:complications / Q000000981:diagnostic imaging*; D004211:Disseminated Intravascular Coagulation / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014470:Umbilical Cord / Q000002:abnormalities / Q000000981:diagnostic imaging; D014471:Umbilical Veins / Q000002:abnormalities* / Q000000981:diagnostic imaging