New glycosidases inhibitors, panosialins D and wD produced by Streptomyces sp. OH-5186.
New panosialin analog, panosialins D and wD have been isolated from the culture broth of Streptomyces sp. OH-5186. Their structures were elucidated as 5-(13-methylpentadecyl)-1,3-benzenediol bis(sodium sulfate) and 5-(13-methylpentadecyl)-1,3-benzenediol 1-(sodium sulfate), respectively. They showed strong inhibitory activity against alpha-mannosidase, alpha-glucosidase, and beta-glucosidase. Panosialins wA-wD mixture also showed weak mitogenic activity but suppressed the mitogen induced activity.
Yamada
H
H
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Shiomi
K
K
Xu
Q
Q
Nagai
T
T
Shibata
M
M
Oya
I
I
Takahashi
Y
Y
Omura
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D008934:Mitogens / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000187:drug effects; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D008934:Mitogens; D012118:Resorcinols; C093245:panosialin D; C093246:panosialin wD; D006026:Glycoside Hydrolases