[Experimental study on the processed drug of castor seeds in the therapy of pulmonary carcinoma].
In this study, castor seeds were processed by one of the traditional Chinese methods, LD50 was measured and tumor inhition tests in nude mice bearing human pulmonary carcinoma were conducted. The results showed that the processing method was able to lower the toxicity of castor seeds and maintain their antitumor effect, thus providing an experimental basis for oral administration of castor seeds in the therapy of pulmonary carcinoma.
Chen
B X
BX
Affiliated Ganquan Hospital, Shanghai Railway Medical College.
Ding
Y S
YS
Chen
L G
LG
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use* / Q000633:toxicity; D002367:Ricinus communis; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D006358:Hot Temperature; D007928:Lethal Dose 50; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D010947:Plants, Toxic; D013678:Technology, Pharmaceutical; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal