title: Enhanced predictability of myocardial infarction in Japanese by combined genotype analysis.
abstract: To explore the genes responsible for myocardial infarction and restenosis after percutaneous transluminal coronary angioplasty, we performed association studies of the polymorphisms of the angiotensinogen and angiotensin-converting enzyme (ACE) genes. In the first study, normotensive myocardial infarction patients (n = 103) and control subjects (n = 103), who were matched for established risk factors with the myocardial infarction patients, were randomly selected. The angiotensinogen-TT genotype (T indicates threonine instead of methionine at position 235) was more frequent in the myocardial infarction group than in the control group (P < .05). The ACE-DD genotype (D indicates a deletion polymorphism in intron 16) was also more frequent in the myocardial infarction group (P < .0001). The odds ratio estimated by the combined analysis of the angiotensinogen-TT and ACE-DD genotypes (11.2) was markedly increased compared with that estimated separately from the angiotensinogen-TT (1.75) or ACE-DD (4.43) genotype. In the second study, we investigated 91 consecutive patients with acute myocardial infarction who underwent successful direct angioplasty. Combined analysis showed that the angiotensinogen-TT genotype did not enhance the predictability of myocardial infarction from the ACE-DD genotype. In conclusion, the angiotensinogen-TT genotype is a predictor for myocardial infarction, as well as the ACE-DD genotype, and the combined analysis of the angiotensinogen-TT and ACE-DD genotypes further enhanced the predictability of myocardial infarction in Japanese, suggesting its future clinical usefulness.
authors.affiliation: Department of Geriatric Medicine, Osaka (Japan) University Medical School.
authors.forename: A
authors.initials: A
authors.lastname: Kamitani
authors.forename: H
authors.initials: H
authors.lastname: Rakugi
authors.forename: J
authors.initials: J
authors.lastname: Higaki
authors.forename: M
authors.initials: M
authors.lastname: Ohishi
authors.forename: S J
authors.initials: SJ
authors.lastname: Shi
authors.forename: S
authors.initials: S
authors.lastname: Takami
authors.forename: Y
authors.initials: Y
authors.lastname: Nakata
authors.forename: Y
authors.initials: Y
authors.lastname: Higashino
authors.forename: K
authors.initials: K
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Mikami
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001483:Base Sequence; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A