title: The fragrance mix and its constituents: a 14-year material.
abstract: Results from 14 years of patch testing with the fragrance mix and its constituents are reviewed. From 1979-1992, 8215 consecutive patients were patch tested with the fragrance mix and 449 (5.5%) had a positive reaction. An increase in the frequency of reactions to fragrance mix was seen from the first 5-year period to the last. Only 54.4% of the patients tested in the last 5-year period with the individual constituents of the mix had at least 1 positive reaction. The results of testing with the constituents are the basis for a discussion of methodological problems. A significant decrease in the frequency of reaction to cinnamic aldehyde was registered, at the same time as the test concentration was reduced from 2% to 1% pet. However, no significant variations in the frequency of reactions to oak moss were seen, notwithstanding a similar reduction in test concentration.
authors.affiliation: Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
authors.forename: J D
authors.initials: JD
authors.lastname: Johansen
authors.forename: T
authors.initials: T
authors.lastname: Menné
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D010476:Perfume / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D012737:Sex Factors; D012867:Skin / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
chemical_list: D010476:Perfume