Regulatory enzymes for the screening of streptomycin producing mutant strains of Streptomyces griseus.
Intermediary enzymes of streptomycin biosynthesis-arginine amidinotransferase and alkaline phosphatase were located at the early fermentation stages. Their relationship with streptomycin production by Streptomyces griseus strains GX-19 and MR-20 was determined and the use of this relationship was made for the screening of streptomycin producing mutant strains.
Maladkar
N K
NK
Biochemistry Division, Hindustan Antibiotics Ltd., Pimpri, Pune.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000579:Amidinotransferases / Q000378:metabolism; D013305:Streptomyces griseus / Q000201:enzymology* / Q000235:genetics; D013307:Streptomycin / Q000096:biosynthesis*
D000579:Amidinotransferases; C021485:arginine amidinotransferase; D000469:Alkaline Phosphatase; D013307:Streptomycin