[Muscle-specific changes in free latissimus dorsi transplantation in the rat model].
The aim of this study is to gain further knowledge concerning the regeneration of reinnervated, freely transplanted muscles. Therefore, we used a rat model, consisting of eight rats per group, in which the latissimus dorsi muscle was transplanted orthotopically, after a period of time of two and twelve weeks harvested, then evaluated histologically and enzyme-histochemically. As controls we used a group of non-operated muscles. At date of removal, the patency of the vascular anastomoses was checked clinically and histologically. Additionally, electrophysiological measurements and conventional and enzyme-histochemical histologies were performed. Two weeks after the free neurovascular flap transplantation, the muscle was not innervated yet, histologically a dissolved pattern of type 1 and type 2 muscle fibers was found. After twelve weeks of time, the muscles were reinnervated again, muscle contraction was positive after electrical stimulation and the typical pattern of fibers was reestablished.
Becker
M H
MH
Klinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinischen Hochschule Hannover am Krankenhaus Oststad.
Lassner
F
F
Dagtekin
F
F
Walter
G F
GF
Berger
A
A
D000818:Animals; D001415:Back; D006651:Histocytochemistry; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000098:blood supply / Q000201:enzymology / Q000294:innervation / Q000637:transplantation*; D051381:Rats; D011917:Rats, Inbred Lew; D012038:Regeneration; D013524:Surgical Flaps; D014654:Vascular Patency
Muskelspezifische Veränderungen bei der freien Latissimus dorsi-Transplantation im Rattenmodell.