Autoimmunity in the eye and its regulation.
Recent studies have provided new information concerning the development of autoimmune-mediated intraocular inflammation (uveitis) and the mechanisms that suppress this sight-robbing process. Newly collected data have led to several interesting advances: the discovery of additional uveitogenic antigens and novel uveitogenic reactions; dissection of the early steps of the pathogenic process; identification of the subsets of lymphocytes that selectively accumulate in the inflamed eye; analysis of the development of tolerance against sequestered antigens in the eye; elucidation of the cellular and molecular events of the anterior chamber-associated immune deviation, the major immunoregulatory mechanism in the eye; the capacity of this mechanism to inhibit and even treat uveitis; and examination of the mechanisms whereby oral tolerance inhibits ocular inflammation.
Gery
I
I
National Eye Institute, NIH, Bethesda.
Streilein
J W
JW
D000595:Amino Acid Sequence; D000818:Animals; D000867:Anterior Chamber / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D005123:Eye / Q000276:immunology*; D005136:Eye Proteins / Q000737:chemistry / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D014605:Uveitis / Q000276:immunology* / Q000517:prevention & control
D001324:Autoantigens; D005136:Eye Proteins; D011948:Receptors, Antigen, T-Cell