title: A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.
abstract: We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a subpopulation of olfactory sensory neurons. The extracellular, putative ligand-binding domain of the olfactory cyclase is similar in primary structure to two guanylyl cyclases expressed in the retina but diverges considerably from other known guanylyl cyclases. The expression of GC-D RNA is restricted to a small, randomly dispersed population of neurons that is within a single topographic zone in the olfactory neuroepithelium and resembles the pattern of the more diverse seven-transmembrane-domain odorant receptors. These observations suggest that GC-D may function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.
authors.affiliation: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235-9050, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Fülle
authors.forename: R
authors.initials: R
authors.lastname: Vassar
authors.forename: D C
authors.initials: DC
authors.lastname: Foster
authors.forename: R B
authors.initials: RB
authors.lastname: Yang
authors.forename: R
authors.initials: R
authors.lastname: Axel
authors.forename: D L
authors.initials: DL
authors.lastname: Garbers
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D006162:Guanylate Cyclase / Q000096:biosynthesis / Q000235:genetics*; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D018034:Olfactory Receptor Neurons / Q000201:enzymology*; D051381:Rats; D011956:Receptors, Cell Surface; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D018000:Receptors, Peptide / Q000096:biosynthesis / Q000235:genetics*; D011994:Recombinant Proteins / Q000096:biosynthesis; D017422:Sequence Analysis, DNA; D014018:Tissue Distribution
chemical_list: D011956:Receptors, Cell Surface; D018000:Receptors, Peptide; D011994:Recombinant Proteins; D006162:Guanylate Cyclase; C484777:Gucy2d protein, rat; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled