A study on children's condition thalassemia using neutron activation analysis and other techniques.
In this study, 50 thalassemia patients were tested using dual-energy X-ray absorptiometry (DEXA) and in vivo neutron activation analysis (IVNAA) to determine their bone mineral status. Both techniques were suitable for this purpose. Lower age was found to correspond to lower liver iron content and higher bone mineral content in the normal range. Patients undergoing treatment with transfusion had higher bone mineral content. Osteopenic patients had higher hepatic iron content than those with normal bone status. In the case of DEXA, bone mineral content (BMC) divided by height cubed was found to be a better indicator of bone mineral status than the BMD usually given. Liver density as determined by DEXA correlates well with hepatic iron.
Krishnan
S
S
Medical Physics Laboratory, Toronto Hospital, Ontario, Canada.
Sturtridge
W C
WC
Olivieri
N F
NF
Collins
A F
AF
Qureshi
R Y
RY
Krishnan
M
M
Belluzzo
N
N
Bogdanovich
E
E
Lui
S M
SM
D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D015519:Bone Density / Q000502:physiology*; D002132:Calcium Radioisotopes / Q000032:analysis; D006801:Humans; D007501:Iron / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D009501:Neutron Activation Analysis; D013789:Thalassemia / Q000503:physiopathology*; D065227:Transfusion Reaction
D002132:Calcium Radioisotopes; D007501:Iron