title: Salivary immunoglobulins in recipients of bone marrow grafts. II. Transient secretion of donor-derived salivary IgA following transplantation of T cell-depleted bone marrow.
abstract: Patients undergoing bone marrow transplantation (BMT) have decreased levels of salivary Ig over long periods of time. However, shortly after transplantation, a transient rise of Ig concentration in their saliva gland is detected. In order to trace the origin of this Ig, seven BM donors were immunized with tetanus toxoid (TT) 4-7 days prior to BMT harvesting. Four patients received BM from non-immunized donors. All but one of the patients had no detectable anti-TT IgA in their parotid saliva prior to BMT. Recipients of T cell-depleted BM from pre-immunized donors transiently displayed high titers of salivary anti-TT IgA 7-28 days after transplantation. No significant anti-TT IgA titers were detected in saliva of patients grafted with non-immunized BM. We conclude that antibody-producing cells activated in the donor are passively transferred with the BM to the recipient. IgA committed cells home to the mucosa-associated lymphoid tissues (MALT) and continue to secrete antibodies until senescence.
authors.affiliation: Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah School of Dental Medicine and Medicine, Jerusalem, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Chaushu
authors.forename: G
authors.initials: G
authors.lastname: Chaushu
authors.forename: A
authors.initials: A
authors.lastname: Garfunkel
authors.forename: S
authors.initials: S
authors.lastname: Slavin
authors.forename: R
authors.initials: R
authors.lastname: Or
authors.forename: E
authors.initials: E
authors.lastname: Yefenof
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D008212:Lymphocyte Depletion; D012463:Saliva / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D013997:Time Factors; D014019:Tissue Donors
chemical_list: D007071:Immunoglobulin A, Secretory; D013745:Tetanus Toxoid