Tissue factor pathway inhibitor: a potent inhibitor of in-vitro coagulation and in-vivo thrombus formation.
Tissue factor pathway inhibitor is established as an important coagulation inhibitor. The knowledge of the relationship between the structure and function of the tissue factor pathway inhibitor molecule has been widely expanded, especially with regard to its interaction with heparin. Perhaps the most important and promising new studies have investigated the possibility, of using tissue factor pathway inhibitor as a potent drug in the treatment of experimental septic shock and arterial and venous thrombosis.
Lindahl
A K
AK
Department of Surgery, Aker University Hospital, Oslo, Norway.
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004357:Drug Synergism; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006493:Heparin / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008074:Lipoproteins / Q000494:pharmacology*; D011485:Protein Binding; D013927:Thrombosis / Q000517:prevention & control*; D014407:Tumor Cells, Cultured
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D006493:Heparin