[Myocardial function after fluid resuscitation with addition of 1-6-FDP in severely burned rabbits].
An experimental study is designed for the evaluation of the effect of fluid resuscitation with addition of 1-6FDP on myocardiac function in severely burned rabbits. 60 rabbits were divided into four groups. Group A (n = 15) served as control without treatment. The animals in group B (n = 15) were treated with 1-6-FDP immediately after burning. The animals in group C (n = 15) were treated with balanced saline solution (BSS). The animals in group D(n = 15) were treated with BSS plus 1-6-FDP. All rabbits sustained 25% TBSA full thickness burn. LVSP, LV +/- dp/dt max and PV were measured before burn, immediately after burn, and 1, 3, 5, 7 h, after burn, except that PV was not measured immediately after burn. The results showed that depression in myocardial contractility and relaxation were noted immediately after severe burn. Fluid resuscitation alone did not significantly improve myocardial function (P > 0.05 compared with control). The administration of 1-6-FDP showed a beneficial effect in improving myocardial contractility and relaxation within 3 hours postburn. With fluid resuscitation plus 1-6-FDP, myocardial contractility and relaxation were improved statistically significantly as compared with the control group (P < 0.01).
Huang
J
J
Department of Burns Surgery, Affiliated Hospital of Yangzhou Medical College.
Cheng
Y
Y
Ye
H
H
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D005260:Female; D005440:Fluid Therapy; D006597:Fructose-Bisphosphatase / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D011897:Random Allocation; D016277:Ventricular Function, Left / Q000187:drug effects*
D006597:Fructose-Bisphosphatase