In vitro susceptibility to 9 antifungal agents of 14 strains of Zygomycetes isolated from clinical specimens.
Fourteen clinical isolates of Zygomycetes were tested for their in vitro susceptibility to nine antifungal agents. Susceptibility assessment was performed using a microtiter broth dilution method. Synthetic broth with YNB and glucose was used for 5-fluorocytosine and BHI broth for all the other antimycotics. Amphotericin B exhibited the strongest activity against all isolates tested. MIC values of other two polyenes--nystatin and pimaricin--ranged within the susceptibility limits, with a little pronounced higher activity of pimaricin. The isolates of the genus Absidia and Syncephalastrum were well sensitive to all antimycotics with the exception of 5-fluorocytosine and naftifine. A very weak or zero growth inhibitory effect against all members of the genera Mucor and Rhizopus was found in azoles, 5-fluorocytosine and naftifine.
Otcenásek
M
M
Institute of Experimental Biopharmaceutics, Joint Research Center of PRO.MED.CS Praha, Czech Republic.
Buchta
V
V
D000499:Allylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000187:drug effects; D009090:Mucorales / Q000187:drug effects*; D012233:Rhizopus / Q000187:drug effects
D000935:Antifungal Agents; D001393:Azoles; D000499:Allylamine; C029178:naftifine; D005437:Flucytosine