title: Dietary fish oil affects food intake, growth and hematologic values of weanling rats.
abstract: The object of this study was to evaluate the effect of increasing amounts of dietary fish oil on growth and hematological variables of the weanling male Sprague-Dawley rat. Animals were fed diets containing either fish oil (FO) or sesame oil (SO) at 5, 10 or 15% (w/w) for 31 d. Growth retardation and reduced food intake was noted in groups fed FO. Hemoglobin (Hb) concentration diminished when the dietary FO was above 5% (w/w). FO is a poor source of (n-6) fatty acids. We postulate that a partial deficiency in (n-6) polyenic family, is a consequence of the increasing amounts of FO in the diets, that may affect growth and erytropoiesis. In this report we show evidence supporting the hypothesis that diets enriched with fish oil can alter normal growth and induced hematological changes in the male weanling rat.
authors.affiliation: Sección de Lipidología, Facultad de Medicina-Universidad Central de Venezuela.
authors.forename: Z
authors.initials: Z
authors.lastname: Domínguez
authors.forename: V
authors.initials: V
authors.lastname: Bosch
mesh_terms: D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D004920:Erythropoiesis / Q000187:drug effects; D005395:Fish Oils / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects*; D006454:Hemoglobins / Q000032:analysis*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014886:Weaning
chemical_list: D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D006454:Hemoglobins