title: Crohn's disease associated with growth hormone secretory dysfunction.
abstract: A 10-year-old boy presented in 1989 with repeated episodes of vomiting, abdominal distension and severe growth retardation. Endocrinologic examination indicated growth hormone (GH) secretory dysfunction. Administration of recombinant human GH (rhGH) led to growth, but the patient discontinued treatment. He was readmitted to our hospital in 1993, at the age of 16. His stature was very short. Laboratory findings suggested malnutrition. Radiologic examination revealed regional stenosis and a cobblestone appearance of the intestine. The histologic diagnosis was compatible with Crohn's disease. Administration of prednisolone alleviated gastrointestinal symptoms with the improvement of GH secretory function.
authors.affiliation: Third Department of Internal Medicine, Okayama University Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Ogura
authors.forename: J
authors.initials: J
authors.lastname: Kageyama
authors.forename: Y
authors.initials: Y
authors.lastname: Itano
authors.forename: T
authors.initials: T
authors.lastname: Yamauchi
authors.forename: T
authors.initials: T
authors.lastname: Oishi
authors.forename: T
authors.initials: T
authors.lastname: Aita
authors.forename: N
authors.initials: N
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Ogasa
authors.forename: K
authors.initials: K
authors.lastname: Ota
authors.forename: Z
authors.initials: Z
authors.lastname: Ota
mesh_terms: D002648:Child; D003424:Crohn Disease / Q000150:complications*; D004393:Dwarfism, Pituitary / Q000150:complications*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D008297:Male
chemical_list: D013006:Growth Hormone