title: Failure of intravenous low dose midazolam to influence memory recall in drug paralysed post-operative patients sedated with papaveretum.
abstract: Sedation of ventilated patients in the Intensive Care Unit generates a tension between adequate sedation to maintain comfort and ease of ventilation and over sedation with undesirable prolongation of ventilation and delays in discharge. Studies in animals suggest very low dose midazolam, but not higher doses, potentiate the sedative effects of opiates. We undertook a trial of opiate sedation versus opiate sedation plus low dose midazolam (1 mg/hour) to determine whether a similar effect could be demonstrated in man. Although ventilator time and the duration of admission to Intensive Care was not prolonged by the addition of midazolam, we were unable to demonstrate any statistically significant benefit with regard to memory recall.
authors.forename: A
authors.initials: A
authors.lastname: Henderson
authors.forename: J
authors.initials: J
authors.lastname: Dipplesman
authors.forename: J
authors.initials: J
authors.lastname: Miller
mesh_terms: D016292:Procedural Sedation / Q000379:methods*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D009892:Opium / Q000627:therapeutic use*; D011182:Postoperative Care; D012121:Respiration, Artificial; D017211:Treatment Failure
chemical_list: D009892:Opium; D008874:Midazolam