Ischemia/reperfusion injury is aggravated by an iron supplemented diet and is partly prevented by simultaneous antioxidant supplementation.
In humans high levels of storage iron as well as low iron binding capacity are considered risks for ischemic heart disease development. The aim of this study was to determine whether a diet containing iron to a concentration of the recommended upper limit alters the degree of myocardial ischemic/reperfusion injury on rats and whether simultaneous antioxidant supplementation had any effect. Results indicate that the iron supplemented diet increased the degree of oxidative injury while simultaneous antioxidant supplementation prevented much of this increase. The mechanism for this was probably an elevated hydroxyl radical production due to the enlarged transit iron pool.
van Jaarsveld
H
H
Department of Chemical Pathology, University of the Orange Free State, Bloemfontein, Republic of South Africa.
Kuyl
J M
JM
Wiid
N M
NM
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D005260:Female; D005527:Food, Fortified; D007501:Iron / Q000009:adverse effects*; D008054:Lipid Peroxides / Q000032:analysis; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008929:Mitochondria, Heart / Q000502:physiology; D017202:Myocardial Ischemia / Q000209:etiology* / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000209:etiology* / Q000517:prevention & control*; D009206:Myocardium / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013438:Sulfhydryl Compounds / Q000032:analysis; D014810:Vitamin E / Q000032:analysis
D000975:Antioxidants; D008054:Lipid Peroxides; D013438:Sulfhydryl Compounds; D014810:Vitamin E; D007501:Iron