[Autoimmune thrombocytopenia in pregnant women: diagnosis, treatment and prevention of complications in children].
9 pregnancies (in 6 women) complicated by autoimmune thrombocytopenia were studied. Corticosteroids and/or azathioprine and/or intravenous immunoglobulins (IgG i.v.) were administered to 5 women during pregnancy. 1 complete remission (CR) was achieved after 3 mo. of treatment by corticosteroids and azathioprine. In peripartum period the treatment was administered in 7 cases (corticosteroids, IgG i.v., platelet transfusion). There were no haemorrhagic complications during peripartum period (8 vaginal delivery, 1 cesarean section). In 3 of 5 examined cases IgG antiplatelet antibody was detected. Study group was to small to define the correlation between level of antiplatelet antibodies and neonatal thrombocytopenia. 10 infants were born. 4 infants (including siblings) were found to have normal platelet counts immediately after delivery. They mothers were treated by IgG i.v. in 2 cases and 1 women in CR at the time of delivery. 4 infants were thrombocytopenic but required no treatment. Duration time of thrombocytopenia was 1 to 4 weeks. In these cases mothers were treated only by corticosteroids or had no therapy.
Kopec
I
I
Kliniki Hematologicznej Instytutu Hematologii i Transfuzjologii, Warszawa.
Słomkowski
M
M
Puzyna
W
W
Maslanka
K
K
Maj
S
S
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D001379:Azathioprine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007231:Infant, Newborn; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000628:therapy*; D011256:Pregnancy Outcome; D012074:Remission Induction; D013921:Thrombocytopenia / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous; D001379:Azathioprine
Autoimmunologiczna małopłytkowosc u kobiet w ciazy: rozpoznawanie, leczenie, zapobieganie powikłaniom u dzieci.