Effect of calcitriol replacement on serum calcitonin and parathyroid hormone levels in CAPD patients.
Calcitonin-secreting cells, 'C cells', have specific receptors for calcitriol, thus the calcitriol deficiency in uraemia may affect calcitonin secretion and/or production. The aim of the present study was to evaluate in CAPD patients the effect of calcitriol replacement (4 weeks of oral calcitriol, 0.5 micrograms/day) on both, basal calcitonin concentration and calcitonin response to calcium infusion (calcium gluconate, 3 mg/kg/h). Calcitriol replacement produced a normalization of serum calcitriol level without a significant change in serum calcium concentration. After calcitriol replacement, basal calcitonin increased from 78 +/- 15 to 101 +/- 13 pg/ml, P < 0.05. The increment in calcitonin induced by a calcium infusion was lower after (15 +/- 4 pg/ml) than before (29 +/- 4 pg/ml) calcitriol replacement. In addition, calcitriol administration induced a decrease in serum PTH level. Replacement of calcitriol in CAPD patients produced an increase in serum calcitonin concentration and a decrease in the calcitonin response to hypercalcaemia.
Quesada
J M
JM
Servicio de Nefrologia, Hospital Reina Sofia, Cordoba, Spain.
Rodriguez
M
M
Calderon de la Barca
J M
JM
Alvarez-Lara
A
A
Martín-Malo
A
A
Mateo
A
A
Martinez
M E
ME
Aljama
P
P
D000284:Administration, Oral; D000368:Aged; D002116:Calcitonin / Q000097:blood*; D002117:Calcitriol / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000008:administration & dosage / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood; D007262:Infusions, Intravenous; D007674:Kidney Diseases / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010531:Peritoneal Dialysis, Continuous Ambulatory
D010281:Parathyroid Hormone; D002116:Calcitonin; D002117:Calcitriol; D002118:Calcium