Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.
Doherty
A M
AM
Department of Chemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.
Patt
W C
WC
Edmunds
J J
JJ
Berryman
K A
KA
Reisdorph
B R
BR
Plummer
M S
MS
Shahripour
A
A
Lee
C
C
Cheng
X M
XM
Walker
D M
DM
D000284:Administration, Oral; D000818:Animals; D003001:Cloning, Molecular; D004149:Dioxoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D065128:Endothelin Receptor Antagonists; D006801:Humans; D008297:Male; D010455:Peptides / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin / Q000235:genetics; D013329:Structure-Activity Relationship
D004149:Dioxoles; D065128:Endothelin Receptor Antagonists; C093322:PD 155080; C093321:PD 156707; D010455:Peptides; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin