Impact of alcohol consumption and cigarette smoking on stroke among the elderly in Taiwan.
OBJECTIVE
We investigated the influence of alcohol consumption and cigarette smoking on all types of stroke and cerebral infarction, in particular among a representative sample of elderly residents in Taiwan.


METHODS
This study was a component of a nationwide survey of health and living status of residents aged 65 years or older in Taiwan in which subjects received detailed physical, neurological, and laboratory examinations. Inquiries were made about medical history, and information on the amount and duration of drinking and smoking was obtained. Diagnoses of stroke were made according to the results of brain computed tomography at the onset of disease or were based on criteria established by the World Health Organization.


RESULTS
Of the 2600 subjects, there were 155 elderly persons with stroke (prevalence, 6%). Excessive drinking of more than 367.6 g/wk of alcohol was associated with a high prevalence of cerebral infarction. Consumption of < or = 367.5 g/wk of alcohol did not have an influence on stroke prevalence. The relationship between duration of alcohol drinking and stroke was equivocal. More than 30 pack-years of cigarette smoking was a significant risk factor for all types of stroke and cerebral infarction in particular. Using multiple logistic regression to control for possible confounders, it was found that smoking was an independent risk factors for all stroke and was of borderline significance for cerebral infarction. Although excessive drinking was a significant risk factor for cerebral infarction in univariate analysis, this effect was lost after adjustment for other confounders.


CONCLUSIONS
Cigarette smoking was a more important risk factor for stroke and cerebral infarction than excessive drinking of alcohol.
Lee
T K
TK
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Republic of China.
Huang
Z S
ZS
Ng
S K
SK
Chan
K W
KW
Wang
Y S
YS
Liu
H W
HW
Lee
J J
JJ
D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000209:etiology*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013624:Taiwan / Q000453:epidemiology