title: Alleviation of cytotoxic therapy-induced normal tissue damage.
abstract: Cytotoxic chemotherapy and radiation therapy damage normal body tissues, resulting in stomatitis, conjunctivitis, esophagitis, proctitis, and dermatitis. Pursuant to this, the North Central Cancer Treatment Group has developed a series of clinical trials designed to study antidotes for these pathologic processes. These trials have demonstrated clinically helpful therapies (eg, oral cryotherapy for decreasing mucositis induced by 5-fluorouracil) and also have demonstrated lack of benefit for other proposed treatments. Results from several ongoing clinical trials should become available in the near future.
authors.affiliation: Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Loprinzi
authors.forename: R L
authors.initials: RL
authors.lastname: Foote
authors.forename: J
authors.initials: J
authors.lastname: Michalak
mesh_terms: D002710:Chlorhexidine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D017679:Cryotherapy; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology; D004941:Esophagitis / Q000188:drug therapy* / Q000209:etiology; D005128:Eye Diseases / Q000139:chemically induced / Q000628:therapy*; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D011832:Radiation Injuries / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D013280:Stomatitis / Q000139:chemically induced / Q000628:therapy*; D013392:Sucralfate / Q000627:therapeutic use
chemical_list: D013392:Sucralfate; D002710:Chlorhexidine; D005472:Fluorouracil