title: Host-range control of a retroviral disease: Friend erythroleukemia.
abstract: Since its discovery in 1957, Friend viral erythroleukemia has been the major model for understanding host genetic barriers to retroviral diseases and has facilitated the discovery of many polymorphic leukemia-control genes of mice. Some of these genes limit helper-virus replication, target-cell (erythroblast) pools or immune responses. At least one host gene appears to block the viral oncoprotein.
authors.affiliation: Divn of Hematology and Medical Oncology, Oregon Health Sciences University, Portland 97201-3098, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Hoatlin
authors.forename: D
authors.initials: D
authors.lastname: Kabat
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005622:Friend murine leukemia virus / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D007942:Leukemia, Experimental / Q000821:virology; D051379:Mice; D008969:Molecular Sequence Data; D012192:Retroviridae Infections / Q000821:virology; D013155:Spleen Focus-Forming Viruses / Q000235:genetics / Q000472:pathogenicity*; D014759:Viral Envelope Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D014759:Viral Envelope Proteins; C078780:glycoprotein gp55, Friend spleen focus-forming virus