title: Tumour volume reduction following gamma knife radiosurgery: the relationship between X-ray and histological findings.
abstract: The case histories of two young ladies with Cushing's disease are described. Both patients were treated first with Gamma Knife radiosurgery and subsequently by microsurgery. The radiosurgery caused a marked reduction in tumour volume but only a partial relief of the endocrinopathy. Comparison of the histological findings with the radiological findings following radiosurgery indicates that confluent necrosis is not a prerequisite for a reduction in tumour volume. It seems more likely that the reduction in tumour volume is related to changes in cellular dynamics.
authors.affiliation: Department of Neurosurgery, Haukeland Hospital, University of Bergen, Norway.
authors.forename: J C
authors.initials: JC
authors.lastname: Ganz
authors.forename: S
authors.initials: S
authors.lastname: Aanderud
authors.forename: S J
authors.initials: SJ
authors.lastname: Mork
authors.forename: A I
authors.initials: AI
authors.lastname: Smievoll
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery* / Q000648:ultrastructure*; D000293:Adolescent; D000328:Adult; D003238:Connective Tissue / Q000528:radiation effects; D003480:Cushing Syndrome / Q000473:pathology / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D010902:Pituitary Gland / Q000473:pathology / Q000601:surgery* / Q000648:ultrastructure*; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery* / Q000648:ultrastructure*; D011829:Radiation Dosage; D011836:Radiation Tolerance; D016634:Radiosurgery