Autoantibodies in scleroderma and tightskin mice.
There is much evidence to suggest that scleroderma in human patients is caused by a fundamental defect in the immune system. In tightskin mice, the scleroderma syndrome is associated with autoimmunity, particularly autoantibodies interacting with scleroderma target antigens.
Bona
C
C
Mount Sinai Medical Center, New York.
Rothfield
N
N
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D012595:Scleroderma, Systemic / Q000276:immunology*; D013577:Syndrome
D001323:Autoantibodies; D001324:Autoantigens