title: [Implantable insulin pump: the first step towards an artificial pancreas].
abstract: Recent improvements in miniaturization of implantable pumps and the ability of their control by teletransmission allow implantation of autonomous pumps which administer insulin into the peritoneal cavity. Fifty-six patients with diabetes mellitus underwent implantation of 66 pumps with a mean function life of 21.8 months per patient. No patient has died to date. Tolerance of implanted components was good. Morbidity was limited to local events, in this series 4 cutaneous erosions, two of them leading to final pump explantation. Mean global blood-sugar, pre- and post-prandial blood-sugar, and glycosylated hemoglobin assays were all lower versus pre-implantation assays. A statistically significant difference was demonstrated regarding mean global blood-sugar. The frequency of severe hypoglycemia incidents (2 in our series) and biochemical hypoglycemia (blood-sugar < 65 mg/100 ml) was decreased, representing a major benefit of the technique. The patients well-being and quality of life were notably improved. Implantable insulin-pump may be offered as alternative treatment to conventional insulin-therapy, especially in cases of diabetes which are difficult to control and particularly in cases with frequent hypoglycemic malaise.
authors.affiliation: Service de Chirurgie Digestive et Endocrinienne, Clinique Chirurgicale A, Hôpital Civil, Les Hôpitaux Universitaires, Strasbourg.
authors.forename: M
authors.initials: M
authors.lastname: Vix
authors.forename: D
authors.initials: D
authors.lastname: Mutter
authors.forename: N
authors.initials: N
authors.lastname: Jeandidier
authors.forename: S
authors.initials: S
authors.lastname: Boivin
authors.forename: M
authors.initials: M
authors.lastname: Pinget
authors.forename: J
authors.initials: J
authors.lastname: Marescaux
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000628:therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D015918:Infusion Pumps, Implantable; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin
vernacular_title: La pompe à insuline implantable: le premier pas vers un pancréas artificiel.