title: Simple rapid hydrolysis of acetyl protecting groups in the FDG synthesis using cation exchange resins.
abstract: A new solid phase method for hydrolysis of acetyl groups from the intermediate 2-[18F]fluoro-2-deoxyglucose tetraacetate ([18F]FDG-Ac4) was developed. Fast cleavage occurs with Dowex 50 sulfonic acid resin (H+ form) at approximately 100 degrees C in the absence of bulk water. [18F]FDG-Ac4 reaction mixtures were efficiently converted to neutral aqueous solutions of pure FDG in 10-15 min. The method avoids problems associated with liquid acids and can be easily integrated into existing [18F]FDG procedures.
authors.affiliation: Indiana University School of Medicine, Department of Radiology, Indianapolis 46202, USA.
authors.forename: G K
authors.initials: GK
authors.lastname: Mulholland
mesh_terms: D002411:Cation Exchange Resins; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006868:Hydrolysis
chemical_list: D002411:Cation Exchange Resins; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose