[Do halogenated anesthetics protect from ischemic and reperfusion myocardial injuries?].
Ischaemia and reperfusion of the myocardium are associated with cellular injuries leading to a decrease of contractile function and the occurrence of arrhythmias. As reperfusion of an ischaemic heart results in an intracellular overload of calcium, a calcium blocking agent pretreatment has been shown to exert a protective effect. By altering myocardial calcium fluxes, volatile anesthetics might also protect the myocardium from ischaemic damage and reperfusion injuries. A beneficial effect of volatile anesthetics on the ischaemic myocardium has been shown in numerous studies. These agents decrease the severity of ischaemia as well as the incidence of reperfusion arrhythmias and improve recovery of myocardial mechanics during reperfusion. They also preserve myocardial energetics and protect from oxygen-derived free radicals injury. However, some studies do not support these protective effects. The wide discrepancy between the various protocols might explain the discrepancy of the results. Enflurane and halothane seem to be more efficient than isoflurane. This cannot only be explained by different cardiovascular effects, but also by a specific effect on myocardial cells. Halothane and enflurane mainly decrease intracellular calcium availability by a direct effect on sarcoplasmic reticulum, while isoflurane only decreases the transsarcolemnal calcium entry. Enflurane and halothane have more beneficial effects than isoflurane on free radicals induced myocardial injuries. In conclusion, despite a wide diversity between the different studies, halothane and enflurane have better protective properties against ischaemia and reperfusion myocardial injuries than isoflurane.
Louvier
N
N
Département d'Anesthésie-Réanimation, Hôpital du Bocage, Dijon.
Lançon
J P
JP
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D002415:Cats; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology*; D005609:Free Radicals; D006221:Halothane / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007530:Isoflurane / Q000494:pharmacology*; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D012107:Research Design; D013552:Swine
D015220:Calcium Channels; D005609:Free Radicals; D004737:Enflurane; D007530:Isoflurane; D006221:Halothane
Les anesthésiques halogénés protègent-ils contre les lésions myocardiques d'ischémie et de reperfusion?