Empty bladder and dehydrated pelvic patch water uptake in Bufo marinus: inhibition by captopril.
Dehydration (10.3 +/- 2.2%, N = 7) caused a significant increase in pelvic patch water uptake (Jv) from 875 +/- 86 (N = 21) to 2130 +/- 150 (N = 21) cm3.cm-2 x 10(-7), while the pectoral Jv increased from 258 +/- 31 (N = 21) to 545 +/- 75 (N = 21 cm3.cm-2 x 10(-7). Captopril inhibited the pelvic patch Jv in empty bladder toads decreasing the Jv from 978 +/- 45 (N = 27) to 607 +/- 38 (N = 27) cm3.cm-2 x 10(-7). In dehydrated toads (15 +/- 2%, N = 14), captopril reduced the pelvic patch Jv from 1807 +/- 213 (N = 21) to 957 +/- 91 (N = 21) cm3.cm-2 x 10(-7). Captopril injection decreased the blood pressure in dehydrated toads from 25.6 +/- 1.9 (N = 21) to 16.9 +/- 1.5 (N = 21) mmHg with no change in heart rate.
McDevitt
V
V
Department of Biology and Biophysics Center, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA.
Kenedy
A
A
Parsons
R H
RH
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002024:Bufo marinus / Q000502:physiology*; D002216:Captopril / Q000494:pharmacology*; D003681:Dehydration / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects*; D014867:Water / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000502:physiology
D014867:Water; D002216:Captopril