title: Cytokine and growth factor regulation of macrophage scavenger receptor expression and function.
abstract: Regulation of macrophage scavenger receptor (MSR) activity may be an important determinant of the extent of atherogenesis and the efficacy of host defense. The effect of M-CSF on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M-CSF markedly and selectively increased MSR synthesis in murine macrophages (M phi); post-translationally the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally M-CSF enhanced modified lipoprotein uptake and increased divalent cation-independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation. In addition, the Th1 cytokine (gamma-interferon) and Th2 cytokine (interleukin-4) had differential effects on MSR glycosylation in vitro suggesting a further possible regulatory role by these lymphokines on macrophage MSR function.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: W J
authors.initials: WJ
authors.lastname: de Villiers
authors.forename: I P
authors.initials: IP
authors.lastname: Fraser
authors.forename: S
authors.initials: S
authors.lastname: Gordon
mesh_terms: D001161:Arteriosclerosis / Q000276:immunology; D016207:Cytokines / Q000502:physiology*; D015536:Down-Regulation / Q000502:physiology; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology*; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000502:physiology*; D051116:Receptors, Scavenger; D015854:Up-Regulation / Q000502:physiology
chemical_list: D016207:Cytokines; D008077:Lipoproteins, LDL; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D016173:Macrophage Colony-Stimulating Factor