title: Hitchhiking and associative overdominance at a microsatellite locus.
abstract: The possible effects of a selected locus on a closely linked microsatellite locus are discussed and analyzed in terms of coalescent theory and models of the mutation process. Background selection caused by recurrent deleterious mutations will reduce the variance of allele size at a microsatellite locus. The occasional substitution of advantageous alleles (genetic hitchhiking) will also reduce the variance, but a high mutation rate at a microsatellite locus can restore the variance relatively rapidly. Overdominance at the selected locus will increase the variance at the microsatellite locus and create partitioning of the variation in allele size among gametes carrying one or the other of the overdominant alleles. These results suggest that neutral microsatellite loci can provide indicators of selective processes at closely linked loci.
authors.affiliation: Department of Integrative Biology, University of California at Berkeley, 94720, USA.
authors.forename: M
authors.initials: M
authors.lastname: Slatkin
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D004276:DNA, Satellite / Q000235:genetics*; D005799:Genes, Dominant / Q000235:genetics; D008040:Genetic Linkage; D014644:Genetic Variation / Q000235:genetics; D008957:Models, Genetic; D009154:Mutation
chemical_list: D004276:DNA, Satellite