title: Copper metabolism in analbuminaemic rats fed a high-copper diet.
abstract: Copper metabolism in male Nagase analbuminaemic (NA) rats was compared with that in male Sprague Dawley (SD) rats fed purified diets containing either 5 or 100 mg Cu/kg diet. Dietary copper loading increased hepatic and kidney copper concentrations in both strains to the same extent, but baseline values were higher in the NA rats. There was no strain difference in true and apparent copper absorption nor in faecal endogenous and urinary copper excretion. NA rats had higher levels of radioactivity in kidneys at 2 hr after intraperitoneal administration of 64Cu. As based on the distribution of added 64Cu, about 70% of plasma copper appeared to be in the non-protein compartment in the NA rats, whereas in SD rats, it was only about 1%. It is concluded that the NA rats are able to maintain a relatively normal metabolism of copper, even after dietary copper challenge. In the NA rats, zinc concentrations in kidneys, liver and urinary zinc excretion were elevated when compared with SD rats. The high-copper diet did not affect tissue zinc concentrations and apparent zinc absorption in both strains of rats.
authors.affiliation: Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Yu
authors.forename: G J
authors.initials: GJ
authors.lastname: Van den Berg
authors.forename: A C
authors.initials: AC
authors.lastname: Beynen
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D003300:Copper / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000737:chemistry; D005527:Food, Fortified; D007274:Injections, Intraperitoneal; D007408:Intestinal Absorption / Q000502:physiology; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000172:deficiency*; D013045:Species Specificity; D014018:Tissue Distribution; D015032:Zinc / Q000652:urine
chemical_list: D012709:Serum Albumin; D003300:Copper; D015032:Zinc