Reduced and oxidized forms of glutathione and alpha-tocopherol in the cerebrospinal fluid of parkinsonian patients: comparison between before and after L-dopa treatment.
In the cerebrospinal fluid of untreated patients with Parkinson's disease (PD) the concentrations of reduced glutathione (GSH) and alpha-tocopherol (alpha-TOH) were unaltered but the concentration of oxidized glutathione (glutathione disulfide, GSSG) (P < 0.001), the GSSG/GSH ratio (P < 0.06), alpha-tocopherol quinone (alpha-TQ) (P < 0.001), and the alpha-TQ/alpha-TOH ratio (P < 0.01) were reduced significantly. In L-dopa-treated patients, the concentrations of GSH, GSSG, and the alpha-TQ concentration and the alpha-TQ/alpha-TOH ratio (P < 0.05) increased compared with untreated PD patients. These results suggest that oxidation of GSH and alpha-TOH is decreased in untreated PD patients, but is activated to a control level or more after L-dopa treatment.
Tohgi
H
H
Department of Neurology, Iwate Medical University, Morioka, Japan.
Abe
T
T
Saheki
M
M
Hamato
F
F
Sasaki
K
K
Takahashi
S
S
D000368:Aged; D005978:Glutathione / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid* / Q000378:metabolism; D019803:Glutathione Disulfide; D006801:Humans; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D014810:Vitamin E / Q000134:cerebrospinal fluid* / Q000378:metabolism
D014810:Vitamin E; D007980:Levodopa; D005978:Glutathione; D019803:Glutathione Disulfide