Evidence of clonality in a child with haemophagocytic lymphohistiocytosis.
DNA from the bone marrow of a child with haemophagocytic lymphohistiocytosis was examined by polymerase chain reaction for evidence of rearrangement of the T-cell receptor delta chain gene. Evidence of clonal rearrangement was detected, supporting a role for abnormalities of T-cell function in the pathogenesis of this disorder.
Owen
G
G
Department of Paediatric Haematology and Oncology, Llandough Hospital, Penarth, South Glamorgan.
Webb
D K
DK
D002999:Clone Cells / Q000502:physiology; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D015616:Histiocytosis, Non-Langerhans-Cell / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction