The effects of KBT-3022, a new anti-platelet agent, on hemorheological properties in guinea pigs.
Using guinea pigs, a study was conducted on the effects of KBT-3022, a new anti-platelet agent, on hemorheological properties in various tests including blood filterability, blood viscosity, shear stress-induced red blood cell (RBC) deformability and contents of ATP and 2,3-diphosphoglycerate (2,3-DPG). Oral administration of KBT-3022 at 1 and 10 mg/kg significantly increased blood filterability, and significantly reduced blood viscosity at 10 mg/kg without changing the hematocrit, plasma fibrinogen concentration or plasma viscosity. KBT-3022 (10 mg/kg, p.o.) improved RBC deformability in response to shear stress, which was evoked by passing the blood through a thin tube. This dose of KBT-3022 also increased the contents of ATP and 2,3-DPG in RBC. These findings indicate that KBT-3022 may reduce blood viscosity as a sequel to improvement of RBC deformability through direct action on RBC. The increase in the intracellular levels of ATP and 2,3-DPG was considered to be involved in this improvement of hemorheological properties. These hemorheological effects of KBT-3022 appear to be promising for the treatment of patients with ischemic vascular disease.
Yamamoto
N
N
New Drug Research Laboratories, Kanebo Ltd., Osaka, Japan.
Yokota
K
K
Yamashita
A
A
Oda
M
M
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001809:Blood Viscosity / Q000187:drug effects; D004163:Diphosphoglyceric Acids / Q000097:blood; D004353:Drug Evaluation, Preclinical; D004907:Erythrocyte Deformability / Q000187:drug effects; D005340:Fibrinogen / Q000032:analysis; D006168:Guinea Pigs; D006400:Hematocrit; D018056:Hemorheology / Q000187:drug effects*; D010431:Pentoxifylline / Q000494:pharmacology; D010949:Plasma / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D013988:Ticlopidine / Q000494:pharmacology
D004163:Diphosphoglyceric Acids; D010975:Platelet Aggregation Inhibitors; D011758:Pyrroles; D013844:Thiazoles; C064847:KB 3022; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate; D005340:Fibrinogen; D013988:Ticlopidine; D001241:Aspirin; D010431:Pentoxifylline