Glibenclamide, a blocker of ATP-sensitive potassium channels, reverses endotoxin-induced hypotension in pig.
In anaesthetized, mechanically ventilated, indomethacin-treated pigs, we infused E. coli endotoxin (LPS, 20 micrograms kg-1 h-1, i.v.). After 150 min of endotoxaemia, 10 mg kg-1 glibenclamide (an ATP-sensitive K+ channel antagonist) was administered i.v. over 5 min. Vascular variables were recorded before (control), after 150 min of endotoxaemia and 5, 15 and 30 min after glibenclamide infusion. Glibenclamide transiently (within 5 min) increased systemic arterial pressure, reduced by LPS administration, without an effect on cardiac output. Our data indicate that ATP-sensitive K+ channels may play a partial role in the vascular changes due to endotoxaemia.
Vanelli
G
G
Institute of Veterinary Physiology and Biochemistry, University of Milan, Italy.
Hussain
S N
SN
Aguggini
G
G
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000502:physiology; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology
D004731:Endotoxins; D008070:Lipopolysaccharides; D026902:Potassium Channel Blockers; D015221:Potassium Channels; C044101:endotoxin, Escherichia coli; D000255:Adenosine Triphosphate; D005905:Glyburide