title: Development of an improved target for [18F]F2 production.
abstract: An A1 body target with improved yields of electrophilic [18F]F2 on the Siemens/CTI 11 MeV proton cyclotron at Wisconsin has been developed. The saturation yield is 3.10 +/- 0.40 GBq/microA for beam currents up to 45 microA. The target has routinely produced 20-40 GBq of [18F]F2 for clinical and experimental use over 1600 microA-h operation, with a maximum yield to date of 45.5 GBq (1.2 Ci). Target design, performance and reliability are discussed.
authors.affiliation: Department of Medical Physics, 1530 Medical Sciences Center, Madison, WI 53706-1532.
authors.forename: A D
authors.initials: AD
authors.lastname: Roberts
authors.forename: T R
authors.initials: TR
authors.lastname: Oakes
authors.forename: R J
authors.initials: RJ
authors.lastname: Nickles
mesh_terms: D000535:Aluminum; D017357:Cyclotrons / Q000295:instrumentation*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes / Q000302:isolation & purification*; D008722:Methods; D009532:Nickel
chemical_list: D005462:Fluorine Radioisotopes; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D009532:Nickel; D000535:Aluminum