A glucan with immunological activities from the tuber of Alisma orientale.
A glucan, called alisman SI, was isolated from the tuber of Alisma orientale Juzepcz. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was 1.1 x 10(4). It is composed solely of D-glucose. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it has a high-branched glucan type structure mainly composed of alpha-1,4-linked D-glucopyranosyl residues with partially alpha-1,6-linked units and both 3,4- and 4,6-branching points. The polysaccharide exhibited significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as a pronounced anti-complementary activity.
Shimizu
N
N
Kyoritsu College of Pharmacy, Tokyo, Japan.
Ohtsu
S
S
Tomoda
M
M
Gonda
R
R
Ohara
N
N
D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000032:analysis; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003169:Complement Inactivator Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004590:Electrophoresis, Paper; D005936:Glucans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008969:Molecular Sequence Data; D012157:Mononuclear Phagocyte System / Q000187:drug effects / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D000516:alpha-Amylases / Q000378:metabolism
D002241:Carbohydrates; D003169:Complement Inactivator Proteins; D005936:Glucans; D010936:Plant Extracts; D000516:alpha-Amylases