Deep cerebral venous thrombosis and hereditary tissue plasminogen activator (t-PA) deficiency.
We describe a patient with defective tissue plasminogen activator (t-PA) release who developed internal cerebral vein thrombosis. She recovered completely and, as shown by MRI, favourable outcome was probably related to vascular recanalisation. Other members of the pedigree had a similar fibrinolytic deficiency without clinical manifestations. The use of oral contraceptives may have contributed to the patient's hypercoagulable state.
Tezzon
F
F
Divisione di Neurologia, Ospedale Maggiore.
Ferrari
G
G
Sbarbaro
V
V
Beltramello
A
A
Arigliano
P L
PL
Negri
M
M
D000328:Adult; D001777:Blood Coagulation; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D003328:Coronary Thrombosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010375:Pedigree; D013924:Thrombophlebitis / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D010959:Tissue Plasminogen Activator / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D003278:Contraceptives, Oral, Hormonal; D010959:Tissue Plasminogen Activator