title: Selective digestive decontamination in multiple trauma patients: cost and efficacy.
abstract: A double-blind randomized placebo-controlled study was carried out to evaluate the efficacy and the cost of selective digestive decontamination (SDD) to prevent nosocomial pneumonia in multiple-trauma patients. Nosocomial infections, particularly pneumonia, were more frequent in the placebo group. The most common infectious agent was Staphylococcus: Staphylococcus aureus in the placebo group and Staphylococcus epidermidis in the SDD group. Methicillin-resistant Staphylococcus epidermidis was detected more often in the SDD group. No methicillin-resistant Staphylococcus aureus was observed in this study. Fewer patients in the SDD group required antibiotherapy. SDD resulted in a saving of about 41% in drug expenditure.
authors.affiliation: Hôpital Nord, Chemin des Bourelly, Marseille, France.
authors.forename: A
authors.initials: A
authors.lastname: Langlois-Karaga
authors.forename: M
authors.initials: M
authors.lastname: Bues-Charbit
authors.forename: A
authors.initials: A
authors.lastname: Davignon
authors.forename: J
authors.initials: J
authors.lastname: Albanese
authors.forename: O
authors.initials: O
authors.lastname: Durbec
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: N
authors.initials: N
authors.lastname: Morati
authors.forename: G
authors.initials: G
authors.lastname: Balansard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003365:Costs and Cost Analysis; D003428:Cross Infection / Q000517:prevention & control*; D004064:Digestive System / Q000382:microbiology*; D004311:Double-Blind Method; D006801:Humans; D007902:Length of Stay; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000517:prevention & control*; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents