Ginsenoside Rg1 modulates ingestive behavior and thermal response induced by interleukin-1 beta in rats.
Effects of ginsenoside Rg1 (Rg1), a major component of panax ginseng, on changes in ingestive behavior and rectal temperature induced by interleukin-1 beta (IL-1 beta) were investigated in rats. Intraperitoneal (ip) injection of IL-1 beta suppressed food and water intake and elevated rectal temperature. The suppressive effect of IL-1 beta on water intake was converted to an increase when 4.0 mM Rg1 was continuously infused into the third cerebroventricle (ICV) at a rate of 0.966 microliters/h. The elevation of rectal temperature induced by IL-1 beta was attenuated by ICV infusion of Rg1. The feeding suppression caused by IL-1 beta was unaffected by ICV infusion of Rg1. These results suggest that sustained ICV infusion of Rg1 may modulate the effects of IL-1 beta on ingestive behaviors, i.e., increase in water intake and sustained decrease in food intake, resulting in a lowering of body temperature.
Kang
M
M
Department of Internal Medicine I, School of Medicine, Oita Medical University, Japan.
Yoshimatsu
H
H
Oohara
A
A
Kurokawa
M
M
Ogawa
R
R
Sakata
T
T
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D036145:Ginsenosides; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D007375:Interleukin-1; D012503:Saponins; C035054:ginsenoside Rg1