Rare case with metastatic involvement of hypothalamo-pituitary and pineal body presenting as hypopituitarism and diabetes insipidus.
An unusual case with metastatic spread of a small oat cell lung carcinoma to the hypothalamo-pituitary region and pineal body presenting as pituitary insufficiency is reported. Computed tomographic scan revealed an isodense mass in the hypothalamo-pituitary region and pineal body that was strongly enhanced by contrast medium. Magnetic resonance imaging demonstrated a downward displacement of the posterior lobe of the pituitary by the hypothalamo-pituitary mass. Dynamic assessment of hypothalamo-pituitary function showed hypopituitarism and diabetes insipidus; partial recovery was observed with the improvement in the carcinoma by chemotherapy. The brain was subsequently irradiated. The patient survived 10 months.
Suganuma
H
H
Department of Internal Medicine, Hamamatsu University School of Medicine.
Yoshimi
T
T
Kita
T
T
Okano
H
H
Suzuki
Y
Y
Oki
Y
Y
Chida
K
K
Sato
A
A
D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000556:secondary*; D003919:Diabetes Insipidus / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology*; D007029:Hypothalamic Neoplasms / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D010870:Pineal Gland; D010911:Pituitary Neoplasms / Q000556:secondary*