Characteristic induction of hepatic metallothionein in mice by tumor transplantation.
Based on the previous finding that hepatic metallothionein (MT) level was tumor-growth dependently elevated in tumor-transplanted mice, the mode of induction of hepatic MT in tumor-bearing mice was comparatively studied with inflammation-induced and stress-subjected mice. The prefeeding with zinc (Zn)-deficient diet for 1 wk suppressed both the growth of tumor and the increase of hepatic MT and Zn in tumor-bearing mice. The postfeeding with Zn-deficient diet also suppressed hepatic MT induction in the course of tumor growth. On the other hand, in the other two experimental model mice, the prefeeding with Zn-deficient diet did not suppress the increase of hepatic MT and Zn. Further, the dexamethasone treatment stimulated hepatic MT induction in tumor-bearing mice, but rather reduced that in inflammation-induced mice. These results suggest that hepatic MT was induced uniquely in tumor-bearing mice and that Zn may play a key role for the induction of hepatic MT by tumor transplantation.
Takeda
A
A
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Tamano
H
H
Sato
T
T
Goto
K
K
Okada
S
S
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000473:pathology; D003907:Dexamethasone / Q000494:pharmacology; D004032:Diet; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis*; D051379:Mice; D009368:Neoplasm Transplantation; D012149:Restraint, Physical; D012510:Sarcoma 180 / Q000378:metabolism* / Q000473:pathology; D013312:Stress, Physiological / Q000378:metabolism; D014425:Turpentine / Q000494:pharmacology; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology
D003907:Dexamethasone; D008668:Metallothionein; D015032:Zinc; D014425:Turpentine