title: Cocaine exposure induces changes in the ganglioside content of rat liver.
abstract: During cocaine exposure, the liver undergoes significant morphological and biochemical changes. We report here changes in the ganglioside pattern of rat liver after repeated administration (over 5 hours, one injection per hour) of a moderate dose of cocaine (10 mg/kg body weight). Cocaine exposure results in an accumulation of more complex gangliosides (GM1, GD1a, GD1b, GT1b and GQ1b) and a reduction of precursors (GM3, GM2, GD3 and GD2). Our results suggest that ganglioside biosynthesis could be affected by an alteration of vesicular transport from cis- to trans-Golgi cisternae produced either by cocaine itself or by some product of cocaine metabolism.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Salamanca, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cabello
authors.forename: M J
authors.initials: MJ
authors.lastname: Ruano
authors.forename: J A
authors.initials: JA
authors.lastname: Cabezas
authors.forename: P
authors.initials: P
authors.lastname: Hueso
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D005732:Gangliosides / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011498:Protein Precursors / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D009626:Terminology as Topic
chemical_list: D005732:Gangliosides; D011498:Protein Precursors; D003042:Cocaine