title: Safety of urgent restorative proctocolectomy with ileal pouch-anal anastomosis for fulminant colitis.
abstract: OBJECTIVE
  Subtotal colectomy with ileostomy is the operation of choice for patients with fulminant colitis. Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) is preferred for patients who undergo elective surgery for ulcerative colitis. We retrospectively evaluated the safety of RPC with IPAA in patients with a moderate form of fulminant colitis.
  
  
  METHODS
  A chart review of 737 patients who underwent RPC with IPAA for ulcerative and indeterminate colitis from 1983 through 1992 was performed. Moderate fulminant colitis was defined as acute disease requiring hospitalization and parenteral steroid therapy, but without hypotension (systolic blood pressure, < 100 mmHg), tachycardia (> 120 beats/min), or megacolon.
  
  
  RESULTS
  Twelve patients with moderate fulminant colitis underwent urgent surgery (1.6 percent). They had been treated preoperatively for 5.1 +/- 2.3 days with intravenous high-dose steroids, total parenteral nutrition, and antibiotics. These patients had a shorter length of disease (P = 0.01), lower hemoglobin, hematocrit, and albumin (P = 0.001), and higher temperature (P = 0.002) and leukocyte count (P = 0.007) than patients undergoing elective surgery. No early septic complications occurred, although perianal abscess occurred in one patient and pouch-anal fistula in another patient, 13 and 14 months after surgery, respectively.
  
  
  CONCLUSIONS
  In carefully selected, hemodynamically stable patients with fulminant colitis and without megacolon, RPC with IPAA can be safely performed.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio, 44195, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Ziv
authors.forename: V W
authors.initials: VW
authors.lastname: Fazio
authors.forename: J M
authors.initials: JM
authors.lastname: Church
authors.forename: J W
authors.initials: JW
authors.lastname: Milsom
authors.forename: T K
authors.initials: TK
authors.lastname: Schroeder
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003092:Colitis / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D003131:Combined Modality Therapy; D017558:Elective Surgical Procedures; D004630:Emergencies; D005260:Female; D005500:Follow-Up Studies; D005769:Gastrointestinal Motility; D006439:Hemodynamics; D006801:Humans; D007081:Ileostomy; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000453:epidemiology; D011239:Prednisolone / Q000627:therapeutic use; D011300:Preoperative Care; D016737:Proctocolectomy, Restorative; D012008:Recurrence; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D000900:Anti-Bacterial Agents; D011239:Prednisolone