title: Cocaine-exposed children: follow-up through 30 months.
abstract: This prospective, blinded study evaluates the effect of in utero cocaine exposure on outcome of nonasphyxiated, term and near-term children born to women of low socioeconomic status. Two hundred nineteen children (101 cocaine-exposed and 118 control) with extensive natal evaluations are evaluated at 6-month intervals. We report here growth, performance on the Bayley Scales of Infant Development (BSID) through 30 months of age, and tone and reflexes at 6 and 12 months. To date, subjects have had 816 follow-up visits, with subject retention greater than or equal to 73%. Cocaine-exposed children showed statistically lower mean weights and smaller mean head circumferences than control children over the 30-month follow-up period (p < or = .011). The percentage of children with abnormal tone and reflexes, however, was similar in the two groups at 6 and 12 months (p > or = .34). Mean BSID Mental Development Index (MDI) and Psychomotor Development Index scores did not differ between the two groups (p > or = .16), although both groups' scores decreased over time (p < .001). Of concern, both cocaine-exposed and control groups had lower mean MDI scores than those published for a group of children of higher socioeconomic status. We conclude that, in our cohort of children, low socioeconomic or minority status may have had a substantial influence on BSID scores whereas in utero drug exposure did not.
authors.affiliation: Division of Neonatology, Albert Einstein Medical Center, Philadelphia, PA 19141, USA.
authors.forename: H
authors.initials: H
authors.lastname: Hurt
authors.forename: N L
authors.initials: NL
authors.lastname: Brodsky
authors.forename: L
authors.initials: L
authors.lastname: Betancourt
authors.forename: L E
authors.initials: LE
authors.lastname: Braitman
authors.forename: E
authors.initials: E
authors.lastname: Malmud
authors.forename: J
authors.initials: J
authors.lastname: Giannetta
mesh_terms: D000328:Adult; D000886:Anthropometry; D001034:Apgar Score; D001835:Body Weight; D002657:Child Development; D002675:Child, Preschool; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007360:Intelligence; D009129:Muscle Tonus; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012018:Reflex; D019966:Substance-Related Disorders
chemical_list: D003042:Cocaine