Prostaglandin G/H synthase-1 messenger RNA relative abundance in human amnion, choriodecidua and placenta before, during and after spontaneous-onset labour at term.
The aim of this study was to determine the relative abundance of prostaglandin G/H synthase-1 (PGHS-1) mRNA in human amnion, choriodecidua and placenta obtained before (n = 5), during (n = 5) and after spontaneous-onset labour and delivery at term (n = 5). PGHS-1 mRNA relative abundance was not affected by labour status (p > 0.1) nor differently expressed between gestational tissues (p > 0.05). These data are consistent with the hypothesis that PGHS-1 is a constitutively expressed isozyme and that an increase in the relative abundance of mRNA encoding this enzyme is not necessary for the labour-associated increase in prostaglandin formation.
Freed
K A
KA
Department of Perinatal Medicine, Royal Women's Hospital, Carlton, Vic., Australia.
Aitken
M A
MA
Brennecke
S P
SP
Rice
G E
GE
D000650:Amnion / Q000737:chemistry*; D002823:Chorion / Q000737:chemistry*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D011462:Prostaglandins G / Q000032:analysis*; D012333:RNA, Messenger / Q000032:analysis*
D011462:Prostaglandins G; D012333:RNA, Messenger