title: Mechanical and histological evaluation of hydroxyapatite-coated, titanium-coated and grit-blasted surfaces under weight-bearing conditions.
abstract: Cylindric titanium rods with different surfaces were axially implanted into the femora of sheep. The three surfaces were grit-blasted titanium, plasma-sprayed titanium and plasma-sprayed hydroxyapatite (HA). After 2 months, a 2-cm segment of the femoral shaft was completely resected to load the implant, and the animals were allowed full weight-bearing for 9 months. Biomechanical and histological evaluation of the implants was undertaken 2 months after implantation and 9 months after the segmental resection. The mechanical testings of well-fixed implants were performed 9 months after segmental resection. Loosening of 45% of the titanium-coated implants was observed in the first 3 weeks, but thereafter, no further loosening occurred. The HA-coated implants remained entirely fixed for 3 weeks, but thereafter, a progressively increasing incidence of loosening up to 55% after 9 months of loading was detected as subsidence on X-radiographs. The maximum push-out strength of the titanium-coated implants was 4.9 MPa compared with 2.3 MPa for HA-coated ones. No significant mechanical interlock between the grit-blasted surface and bone was observed. The HA coating was found to be delaminated in all unstable implants, whereas the titanium coating remained completely intact. Morphometric analyses of well-fixed rods showed complete bony ingrowth onto the HA surface, whereas the contact area between the bone and the two titanium surfaces was less than 40%. Concerning clinical significance bony ingrowth with long-term mechanical interlock between the implant surface and the bone cannot be achieved by grit-blasting or HA-coating.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Chirurgische Universitätsklinik Bergmannsheil, Ruhr Universität, Bochum, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Dávid
authors.forename: J
authors.initials: J
authors.lastname: Eitenmüller
authors.forename: G
authors.initials: G
authors.lastname: Muhr
authors.forename: A
authors.initials: A
authors.lastname: Pommer
authors.forename: H F
authors.initials: HF
authors.lastname: Bär
authors.forename: P A
authors.initials: PA
authors.lastname: Ostermann
authors.forename: T A
authors.initials: TA
authors.lastname: Schildhauer
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000502:physiology; D017886:Durapatite; D019736:Prostheses and Implants; D012756:Sheep; D013499:Surface Properties; D014025:Titanium; D016474:Weight-Bearing
chemical_list: D017886:Durapatite; D014025:Titanium