title: The use of leukocyte-reduced blood components.
abstract: Many of the risks and discomforts associated with blood transfusion may be avoided by removing the contaminating leukocytes from cellular blood components. Leukocyte reduction prevents many febrile reactions that occasionally occur following red cell transfusion and prevents some febrile reactions following platelet transfusion. Prophylactic use of leukocyte-reduced components may prevent primary HLA alloimmunization, which is a principle cause of the refractoriness to platelet transfusion seen in many multiply transfused, thrombocytopenic patients. Leukocyte-reduced components are equally effective in the prevention of CMV as seronegative blood.
authors.affiliation: Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Miller
authors.forename: P D
authors.initials: PD
authors.lastname: Mintz
mesh_terms: D001424:Bacterial Infections / Q000517:prevention & control / Q000635:transmission; D016913:Blood Component Transfusion / Q000009:adverse effects; D002986:Clinical Trials as Topic; D005334:Fever / Q000209:etiology / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007114:Immunization; D007165:Immunosuppression Therapy; D007962:Leukocytes / Q000276:immunology; D015337:Multicenter Studies as Topic; D017713:Platelet Transfusion / Q000009:adverse effects; D015427:Reperfusion Injury / Q000517:prevention & control; D013921:Thrombocytopenia / Q000517:prevention & control; D014777:Virus Diseases / Q000517:prevention & control / Q000635:transmission