6-Hydroxymanzamine A and 3,4-dihydromanzamine A, new alkaloids from the Okinawan marine sponge Amphimedon Sp.
Two new beta-carboline alkaloids, 6-hydroxymanzamine A [1] and 3,4-dihydromanzamine A [2], have been isolated from the Okinawan marine sponge Amphimedon sp. and their structures elucidated on the basis of nmr spectral data.
Kobayashi
J
J
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Tsuda
M
M
Kawasaki
N
N
Sasaki
T
T
Mikami
Y
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D002243:Carbolines / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D012505:Sarcina / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C093033:3,4-dihydromanzamine A; C093034:6-hydroxymanzamine A; D000970:Antineoplastic Agents; D001643:Bridged Bicyclo Compounds; D002243:Carbolines