title: Concentration-controlled trials. What does the future hold?
authors.affiliation: St Bartholomew's Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Johnston
authors.forename: D W
authors.initials: DW
authors.lastname: Holt
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001682:Biological Availability; D017321:Clinical Trials, Phase I as Topic / Q000379:methods* / Q000592:standards / Q000639:trends; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000592:standards / Q000639:trends; D018570:Risk Assessment
chemical_list: D000970:Antineoplastic Agents; D004364:Pharmaceutical Preparations