Recurrent Cushing's disease associated with nephrotic syndrome.
A case of recurrent Cushing's disease with nephrotic syndrome due to membranoproliferative glomerulonephritis (MPGN) is presented. Functional pituitary adenoma recurred 6 years after transsphenoidal pituitary adenomectomy. Due to infiltration into the surrounding tissues, transcranial surgery was performed. However, this failed to induce a remission and thus gamma knife therapy was applied. Histopathological evaluation revealed that the glomerular lesions had progressed to a rather advanced stage of MPGN. Although this association could be coincidental, the recurrence of pituitary macroadenoma might be induced by the cessation of steroid treatment for the nephrotic syndrome.
Tatsumi
T
T
Division of Gastroenterology, Osaka Minami National Hospital.
Morishima
T
T
Watarai
T
T
Kubota
M
M
Kodama
M
M
Matsuhisa
M
M
Imano
E
E
Izumi
M
M
Takama
T
T
Shin
S
S
D000328:Adult; D003480:Cushing Syndrome / Q000150:complications* / Q000473:pathology / Q000628:therapy; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000648:ultrastructure; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D012008:Recurrence