Synthesis of phthalimido-desmuramylpeptide analogues as potential immunomodulating agents.
The preparation of immunologically active phthalimido desmuramylpeptide analogues 2e-h, 4c-d, and 7b is described. The N-acetylmuramic acid in the muramyl dipeptide has been replaced by a phthaloylated acyclic moiety such as N-phthaloylated amino acids 1a-c, 2-(2-phthalimidoethoxy)acetic acid 3, or by the carbocyclic rac. trans-2-(2'-phthalimidocyclohexyloxy)acetic acid 6.
Urleb
U
U
Department of Pharmacy, University of Ljubljana, Slovenia.
Krbavcic
A
A
Sollner
M
M
Kikelj
D
D
Pecar
S
S
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D010455:Peptides; D010797:Phthalimides; D003520:Cyclophosphamide