Behavioral states in the fetal baboon.
This study was designed to characterize behavioral states in the fetal baboon. Automated methods were developed and validated to recognize behavioral states based on relationships among three physiologic variables (EEG patterns, eye movements, heart period variability). Data included twelve 16-h records from 3 chronically instrumented fetal baboons at 0.8-0.9 of term. Randomly generated control records were used to differentiate occurrences of state from chance association of the variables. For 41.2 +/- 4.6% (mean +/- S.E.) of the time, the physiologic variables were synchronous and formed cycles of state with a mean duration of 34.4 min. Components of these cycles had mean +/- S.E. durations of 7.2 +/- 0.3 min for state 1FB (the analogue of quiet sleep in the human infant and state 1F in the human fetus), 20.7 +/- 1.2 min for the state 2FB (the analogue of active sleep in the human infant and state 2F in the human fetus), and 3.6 +/- 0.2 min for state transitions. For 24.6 +/- 2.4% of the time, the state variables exhibited coincidental, state-like agreements, that were not part of state cycles. Finally, for 34.3 +/- 2.7% of the time, there was no systematic agreement among the three variables. These data provide convincing evidence that organized behavioral states are present in the fetal baboon as early as 0.8 of term gestation.
Grieve
P G
PG
Department of Pediatrics,Columbia College of Physicians and Surgeons, New York, NY 10032, USA.
Myers
M M
MM
Stark
R I
RI
D000465:Algorithms; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D016000:Cluster Analysis; D003201:Computers; D004562:Electrocardiography; D004569:Electroencephalography; D004585:Electrooculography; D005133:Eye Movements / Q000502:physiology; D005260:Female; D005323:Fetal Monitoring; D005333:Fetus / Q000502:physiology*; D006321:Heart / Q000502:physiology; D010215:Papio / Q000196:embryology* / Q000502:physiology*; D011247:Pregnancy; D012890:Sleep / Q000502:physiology; D013997:Time Factors