Elevation of circulating NO: its effects on hemodynamics and vascular smooth muscle cell proliferation in rats.
Object of our study was to characterize the effects of elevated circulating NO on hemodynamics and vascular smooth muscle cell proliferation in rats. Administration of molsidomine (10, 25, 50 mg/kg, bid p.o.) was followed by pharmacodynamic effects: elevation of plasma nitrite/nitrate levels and reduction of blood pressure (25 and 50 mg/kg, bid p.o.). Under these conditions no antiproliferative activity occurred in a model of "air dried" carotid artery injury. From these results we conclude that NO does not act as an antiproliferative agent under conditions where smooth muscle cell injury predominates.
Hecker
G
G
BAYER AG, Institute of Cardiovascular and Arteriosclerosis Research, Wuppertal, FRG.
Denzer
D
D
Wohlfeil
S
S
D000818:Animals; D002339:Carotid Arteries / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000032:analysis / Q000187:drug effects; D005470:Fluorometry; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008981:Molsidomine / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood; D051381:Rats; D017208:Rats, Wistar
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D004247:DNA; D008981:Molsidomine