Right-sided endocarditis caused by Staphylococcus aureus in drug abusers.
A prospective, open, and randomized study of right-sided endocarditis caused by Staphylococcus aureus in drug abuse patients is reported. The following parenteral treatments were compared. Group A patients were treated with 2 g of cloxacillin every 4 h and 1.5 mg of gentamicin per kg of body weight every 8 h for 2 weeks. Group B patients were treated with teicoplanin at 10 mg/kg/12 h on the 1st to 3rd days, 6 mg/kg/12 h on the 4th to 7th days, and 7 mg/kg/24 h on the 8th days. Drug abusers with bacteremia caused by S. aureus and suggestive signs of endocarditis were included. Clinical failures were observed in one patient in group A and in four of six patients in group B. Three patients in group B developed breakthrough bacteremia with teicoplanin-susceptible strains on days +6, +14, and +19. Serum teicoplanin levels and serum bactericidal titers showed a decrease in the 2nd week, when dosages received were 7 mg/kg/day. In conclusion, in treatment of right-sided endocarditis caused by S. aureus in drug abusers with teicoplanin, the use of dosages of 7 mg/kg/day is not recommended even if patients have received dosages of 12 mg/kg/day during the 1st week.
Fortún
J
J
Infectious Disease Unit, Hospital Ramón y Cajal, Madrid, Spain.
Pérez-Molina
J A
JA
Añón
M T
MT
Martínez-Beltrán
J
J
Loza
E
E
Guerrero
A
A
D003023:Cloxacillin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*; D015819:Substance Abuse, Intravenous / Q000150:complications*; D017334:Teicoplanin / Q000009:adverse effects / Q000627:therapeutic use*
D005839:Gentamicins; D017334:Teicoplanin; D003023:Cloxacillin