The catabolism of apolipoprotein B from very low density lipoprotein and triglyceride-rich lipoprotein remnants in fasted septic rats.
The catabolism of apolipoprotein B (apo B) from very low density lipoproteins (VLDL) and triglyceride-rich lipoprotein (TRL) remnants in fasted control (C) and Escherichia coli-treated septic (S) rats was measured. In Experiment 1, [125I]VLDL was injected into rats from C and S groups. Blood was collected from 0 to 60 min postdose and apo B was isolated and counted for radioactivity. No significant difference in the half-life (t1/2) or fractional catabolic rate (FCR) of apo B was observed in the VLDL fraction. In Experiment 2, [125I]TRL remnants were injected into rats from C and S groups. Blood was collected from 0 to 90 min postdose and apo B isolated. The t1/2 was 2.5 times longer in the S compared with the C and the FCR was slower in the S rats. These experiments suggest that S rats do not clear triglyceride-rich lipoproteins as easily as normal-sized lipoproteins.
Phetteplace
H
H
Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Maniscalco
M
M
Lanza-Jacoby
S
S
D000821:Animal Feed; D000818:Animals; D001055:Apolipoproteins B / Q000378:metabolism*; D004927:Escherichia coli Infections / Q000378:metabolism*; D005215:Fasting; D007457:Iodine Radioisotopes; D008074:Lipoproteins / Q000737:chemistry; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D018805:Sepsis / Q000378:metabolism*; D013395:Sucrose / Q000494:pharmacology; D014280:Triglycerides / Q000032:analysis
D001055:Apolipoproteins B; D007457:Iodine Radioisotopes; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D013395:Sucrose