[Antiproliferative and antimetastatic effects of UFT on MKL-4 human breast cancer cells transplanted into nude mice].
Prospective studies have suggested that postoperative adjuvant chemotherapy for breast cancer resulted in a lower recurrence rate and a better survival rate. However, there have been little experimental data on the chemotherapeutic agents for the suppression of progression of micrometastasis from breast cancer focus. We recently established a spontaneous metastasis model of MKL-4 human breast cancer cells transplanted into nude mice. In the present paper, both antiproliferative and antimetastatic effects of UFT were studied with this metastasis model. Oral administration of UFT (20 mg/kg daily) given 4 weeks inhibited significantly the growth of MKL-4 tumors in mice. Histological examination revealed a massive necrosis in the treated tumors. UFT also seemed to decrease the frequency of lymph node and distant metastases. In particular, no metastasis was observed in tumor-bearing mice in which the volume of tumors after the UFT-treatment was smaller than that before the treatment. It is premature to conclude that UFT has an antimetastatic effect because the volumes of the tumors of the control group and the treatment groups differed, but at least UFT may have an antimetastatic effect.
Kurebayashi
J
J
Dept. of Endocrine Surgery, Kawasaki Medical School.
Sonoo
H
H
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D008207:Lymphatic Metastasis; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D005641:Tegafur / Q000008:administration & dosage / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014498:Uracil / Q000008:administration & dosage / Q000494:pharmacology
D005641:Tegafur; D014498:Uracil