Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice.
Glial fibrillary acidic protein (GFAP) increases during proestrus in astrocytes of the hypothalamic arcuate nucleus (ARC). These changes are associated with altered astrocyte-neuron contacts and synaptic remodelling, during preparation for the preovulatory gonadotrophin surge. This study of young C57BL/6J mice showed transient elevations of GFAP mRNA on proestrus in the ARC by in situ hybridization. Basal GFAP mRNA was regained within 18 h. We hypothesize that changes in astrocytic GFAP on proestrus result from elevations of GFAP mRNA that are, in turn, driven by ovarian secretions of estradiol.
Kohama
S G
SG
Oregon Regional Primate Research Center, Beaverton, 97006, USA.
Goss
J R
JR
McNeill
T H
TH
Finch
C E
CE
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D011359:Proestrus / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*
D005904:Glial Fibrillary Acidic Protein; D012333:RNA, Messenger