Improvement of the diuretic effect of triamterene via solid dispersion technique with PEG 4000.
The present investigation was designed and undertaken in order to substantiate further contention concerning the universality of the utilization of PEG polymers as matrix carriers. This study could then be considered an attempt to enhance the dissolution rate of triamterene, with the subsequent enhancement in its absorption rate, via solid dispersion using PEG 4000. The approach of solid dispersions was found useful for optimizing the pharmacokinetic of triamterene in rats.
Arias
M J
MJ
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Spain.
Gines
J M
JM
Moyano
J R
JR
Perez-Barrales
M J
MJ
Vela
M T
MT
Rabasco
A M
AM
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004337:Drug Carriers; D005260:Female; D007408:Intestinal Absorption; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D014223:Triamterene / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D014961:X-Ray Diffraction
D004337:Drug Carriers; D011092:Polyethylene Glycols; D014223:Triamterene