title: Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.
authors.affiliation: Department of Chemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Doherty
authors.forename: W C
authors.initials: WC
authors.lastname: Patt
authors.forename: J J
authors.initials: JJ
authors.lastname: Edmunds
authors.forename: K A
authors.initials: KA
authors.lastname: Berryman
authors.forename: B R
authors.initials: BR
authors.lastname: Reisdorph
authors.forename: M S
authors.initials: MS
authors.lastname: Plummer
authors.forename: A
authors.initials: A
authors.lastname: Shahripour
authors.forename: C
authors.initials: C
authors.lastname: Lee
authors.forename: X M
authors.initials: XM
authors.lastname: Cheng
authors.forename: D M
authors.initials: DM
authors.lastname: Walker
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003001:Cloning, Molecular; D004149:Dioxoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D065128:Endothelin Receptor Antagonists; D006801:Humans; D008297:Male; D010455:Peptides / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D004149:Dioxoles; D065128:Endothelin Receptor Antagonists; C093322:PD 155080; C093321:PD 156707; D010455:Peptides; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin