Hormonal profiles in women with breast cancer.
The literature findings on endogenous hormonal profiles in women with breast cancer are reviewed in detail. It is concluded that four sets of findings are valid: (1) diminished adrenal androgen production, probably genetic, in women with premenopausal breast cancer; (2) ovarian dysfunction (luteal inadequacy plus increased testosterone production) in breast cancer at all ages; (3) increased 16 alpha-hydroxylation of estradiol in breast cancer at all ages; and (4) evidence that prolactin is a permissive risk factor for breast cancer, and that the pregnancy-induced decrease in prolactin levels may account for the protective effect of early pregnancy against breast cancer.
Zumoff
B
B
Department of Medicine, Beth Israel Medical Center, New York, USA.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000728:Androgens / Q000502:physiology; D000818:Animals; D000858:Anovulation; D001943:Breast Neoplasms / Q000150:complications / Q000503:physiopathology*; D002648:Child; D004958:Estradiol / Q000502:physiology; D004964:Estriol / Q000502:physiology; D004970:Estrone / Q000502:physiology; D005260:Female; D006728:Hormones / Q000502:physiology*; D006801:Humans; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000378:metabolism; D008550:Melatonin / Q000502:physiology; D008875:Middle Aged; D011374:Progesterone / Q000502:physiology; D011388:Prolactin / Q000502:physiology; D039181:Steroid 16-alpha-Hydroxylase; D013959:Thyroid Diseases / Q000150:complications
D000728:Androgens; D006728:Hormones; D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D039181:Steroid 16-alpha-Hydroxylase; D004964:Estriol; D008550:Melatonin