title: Undiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project.
abstract: The Isle of Ely Diabetes Project is a prospective population-based study of the aetiology and pathogenesis of Type 2 diabetes mellitus. Between 1990 and 1992, 1156 subjects aged between 40 and 65 years underwent a standard 75 g oral glucose tolerance test (OGTT). A total of 1122 individuals who were not known to have diabetes completed the test and were classified according to WHO criteria; 51 subjects (4.5%) had previously undiagnosed diabetes and 188 (16.7%) had impaired glucose tolerance. The subjects with newly diagnosed glucose intolerance were significantly older, more obese, and shorter than those with normal glucose tolerance. Blood pressure, cholesterol, triglyceride, and LDL-cholesterol concentrations were elevated and HDL-cholesterol levels were lower among those with abnormal rather than normal glucose tolerance. In multiple regression analyses stratified by gender and including age, body mass index, and the waist-hip ratio as covariates, there were significant differences between those with normal and abnormal glucose intolerance in blood pressure, triglyceride, and HDL-cholesterol, but not total or LDL-cholesterol. In both male and female subjects, height had a significant independent negative association with the plasma glucose at 120 min after administration of oral glucose (standardized beta coefficient = -0.12, p < 0.01).
authors.affiliation: Department of Community Medicine, University of Cambridge, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Williams
authors.forename: N J
authors.initials: NJ
authors.lastname: Wareham
authors.forename: D C
authors.initials: DC
authors.lastname: Brown
authors.forename: C D
authors.initials: CD
authors.lastname: Byrne
authors.forename: P M
authors.initials: PM
authors.lastname: Clark
authors.forename: B D
authors.initials: BD
authors.lastname: Cox
authors.forename: L J
authors.initials: LJ
authors.lastname: Cox
authors.forename: N E
authors.initials: NE
authors.lastname: Day
authors.forename: C N
authors.initials: CN
authors.lastname: Hales
authors.forename: C R
authors.initials: CR
authors.lastname: Palmer
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D004739:England; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol