Comparative study of methods for determining lanthanide elements in biological materials by using NAA, HPLC postcolumn reaction, and ICP-MS.
Mice were injected intravenously with one of the following elements: Y, La, Ce, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, or Yb, at a dose of 25 mg/kg body wt. After 20 h, the various organs were taken out, and the element concentrations were determined by NAA, HPLC postcolumn reaction, or ICP-MS. The results by these three methods were within the acceptable range. About 85% of the amount administered of each element was found in liver, lung, and spleen.
Chiba
M
M
Juntendo University School of Medicine, Tokyo, Japan.
Shinohara
A
A
Saiki
M
M
Inaba
Y
Y
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003124:Colorimetry; D007202:Indicators and Reagents; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D013058:Mass Spectrometry; D008674:Metals, Rare Earth / Q000032:analysis*; D051379:Mice; D009501:Neutron Activation Analysis; D013154:Spleen / Q000737:chemistry
D007202:Indicators and Reagents; D008674:Metals, Rare Earth