Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody.
A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined immunodeficient (SCID) mice. This antibody also reduced the mass of established tumours xenografted into SCID mice, whereas gastric cancer not expressing c-ErbB-2 exhibited no regression in response to 4D5 treatment. In addition, administration of 4D5 prevented colonisation of cancer cells and prolonged the survival of host SCID mice inoculated i.v. with c-ErbB-2-overexpressing tumour cells. This is the first reported study to show that treatment with a single antibody specific to c-ErbB-2 prolongs the survival of host SCID mice bearing xenotransplanted tumours.
Ohnishi
Y
Y
Central Institute for Experimental Animals, Kawasaki, Japan.
Nakamura
H
H
Yoshimura
M
M
Tokuda
Y
Y
Iwasawa
M
M
Ueyama
Y
Y
Tamaoki
N
N
Shimamura
K
K
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016513:Mice, SCID; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000276:immunology*; D009368:Neoplasm Transplantation; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis / Q000276:immunology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000628:therapy*; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases