title: Hormonal profiles in women with breast cancer.
abstract: The literature findings on endogenous hormonal profiles in women with breast cancer are reviewed in detail. It is concluded that four sets of findings are valid: (1) diminished adrenal androgen production, probably genetic, in women with premenopausal breast cancer; (2) ovarian dysfunction (luteal inadequacy plus increased testosterone production) in breast cancer at all ages; (3) increased 16 alpha-hydroxylation of estradiol in breast cancer at all ages; and (4) evidence that prolactin is a permissive risk factor for breast cancer, and that the pregnancy-induced decrease in prolactin levels may account for the protective effect of early pregnancy against breast cancer.
authors.affiliation: Department of Medicine, Beth Israel Medical Center, New York, USA.
authors.forename: B
authors.initials: B
authors.lastname: Zumoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000728:Androgens / Q000502:physiology; D000818:Animals; D000858:Anovulation; D001943:Breast Neoplasms / Q000150:complications / Q000503:physiopathology*; D002648:Child; D004958:Estradiol / Q000502:physiology; D004964:Estriol / Q000502:physiology; D004970:Estrone / Q000502:physiology; D005260:Female; D006728:Hormones / Q000502:physiology*; D006801:Humans; D008183:Luteal Phase; D007986:Luteinizing Hormone / Q000378:metabolism; D008550:Melatonin / Q000502:physiology; D008875:Middle Aged; D011374:Progesterone / Q000502:physiology; D011388:Prolactin / Q000502:physiology; D039181:Steroid 16-alpha-Hydroxylase; D013959:Thyroid Diseases / Q000150:complications
chemical_list: D000728:Androgens; D006728:Hormones; D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D039181:Steroid 16-alpha-Hydroxylase; D004964:Estriol; D008550:Melatonin