title: Iron lung treatment of acute on chronic respiratory failure: 16 yrs of experience.
abstract: Noninvasive ventilatory supports are gaining a prominent position among ventilatory techniques aimed to improve ventilation in patients with acute-on-chronic respiratory failure (ACRF). It has not yet been established whether these techniques can be considered as a preventive measure to avoid the need for endotracheal intubation, or are really another means to provide full ventilatory support. At our respiratory intensive care unit (RICU), the ventilatory treatment of ACRF has, for many years, been based on a conservative method, which relies on the use of a body ventilator (iron lung) providing intermittent negative pressure ventilation (INPV). From 1975 to 1991, we treated ACRF in 2,116 patients with chronic obstructive pulmonary disease (COPD) and 604 patients with restrictive thoracopulmonary disease (RTD). Two thousand and eleven patients (95%) underwent INPV. The mortality rate during hospitalization was 9.9% for the patients as a whole (10% and 8.9% for COPD and RTD patients, respectively). The mean length of stay in the RICU was 10.5 +/- 9.5 days. Furthermore, we report the results of our previous studies which investigated how the iron lung works, and how it affected the short- and long-term prognosis of COPD patients in ACRF. Finally, in 180 patients, we report the effects of INPV provided by iron lung on the treatment of ACRF with hypoxic hypercapnic coma (HHC). INPV resulted in a significant improvement of arterial blood gas values and pH, associated with a progressive recovery of the level of consciousness. Only 13 patients needed intubation and 41 (23%) died during hospitalization.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Unità di Terapia Intensiva Polmonare, USL 10/D, Villa D'Ognissanti, Firenze, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Corrado
authors.forename: M
authors.initials: M
authors.lastname: Gorini
authors.forename: E
authors.initials: E
authors.lastname: De Paola
authors.forename: G
authors.initials: G
authors.lastname: Bruscoli
authors.forename: D
authors.initials: D
authors.lastname: Tozzi
authors.forename: A
authors.initials: A
authors.lastname: Augustynen
authors.forename: S
authors.initials: S
authors.lastname: Nutini
authors.forename: R
authors.initials: R
authors.lastname: Ginanni
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology / Q000628:therapy*; D011379:Prognosis; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy*; D012189:Retrospective Studies