Curcuminoids as potent inhibitors of lipid peroxidation.
Earlier studies showed that curcumin is a potent inhibitor iron-catalysed lipid peroxidation. Demethoxycurcumin, bisdemethoxycurcumin and acetylcurcumin were tested for their ability to inhibit iron-stimulated lipid peroxidation in rat brain homogenate and rat liver microsomes. Comparison of the results with curcumin showed that all compounds are equally active, and more potent than alpha-tocopherol. These results showed that the methoxy and phenolic groups contribute little to the activity. Spectral studies showed that all compounds could interact with iron. Thus, the inhibition of iron-catalysed lipid peroxidation by curcuminoids may involve chelation of iron.
Sreejayan
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Rao
M N
MN
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002855:Chromatography, Thin Layer; D003474:Curcumin / Q000031:analogs & derivatives / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology; D007502:Iron Chelating Agents / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014810:Vitamin E / Q000494:pharmacology
D007502:Iron Chelating Agents; D014810:Vitamin E; D007501:Iron; D003474:Curcumin; D001205:Ascorbic Acid