title: [Effect of calcium ions on the differentiation of actinomycetes].
abstract: The influence of Ca2+ on the formation of the aerial mycelium in 23 actinomycete strains was studied. It was shown that in concentrations up to 5 mM exogenous Ca2+ induced the formation of the aerial mycelium in 11 out of the 23 actinomycete strains tested. The Ca2+ channel blockers (verapamil and nifedipine), calmodulin inhibitor (chlorpromazine) and Ca2+ chelator (EGTA) inhibited the aerial mycelium formation in 3 streptomycete strains out of the 23 actinomycetes. Chlorpromazine and nifedipine proved to be the most active inhibitors when used in concentrations of 0.2 to 2.5 mumol/disk. The Ca2+ concentrations of 5 mM were found to stimulate the formation of the submerged spores in S. hygroscopicus 155. The activity of ATP synthase was stimulated in the aerial and submerged spores after the Ca2+ uptake.
authors.forename: I V
authors.initials: IV
authors.lastname: Ivanova
authors.forename: K R
authors.initials: KR
authors.lastname: Khristova
authors.forename: S T
authors.initials: ST
authors.lastname: Danova
authors.forename: P A
authors.initials: PA
authors.lastname: Moncheva
mesh_terms: D000192:Actinomycetales / Q000187:drug effects* / Q000502:physiology; D002118:Calcium / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D013171:Spores, Bacterial; D013302:Streptomyces / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
chemical_list: D004533:Egtazic Acid; D014700:Verapamil; D009543:Nifedipine; D002118:Calcium; D002746:Chlorpromazine
vernacular_title: Vliianie ionov kal'tsiia na differentsiatsiiu aktinomitsetov.