[Changes in urethral pressure after intravenous injection of moxisylyte hydrochloride in urethral instability in women. Preliminary results].
OBJECTIVE
To study the action of an alpha blocker, Moxisylyte hydrochloride, during an intravenous test on the course of urethral pressure in women with urethral instability associated with urethral hypertonia.


METHODS
The population consisted of 20 women with a mean age of 38 years, presenting with a clinical disorder of micturition (urinary incontinence: 15 cases, urgency: 17 cases, frequency, 17 cases) present for an average of 4 years and associated with resting urethral pressure variations ranging from 22 to 88 cm H2O (mean: 44.8 cm H2O) and static urethral pressures ranging 72 to 150 cm H2O (mean: 102.5 cm H2O). An urodynamic assessment was performed before and after intravenous injection of Moxisylyte hydrochloride at the dose of 0.5 mg/kg.


RESULTS
Moxisylyte hydrochloride induced a significant reduction of urethral pressure variations, ranging from 8 to 42 cm H2O (mean: 21.9 cm H2O) and static urethral pressures, ranging from 47 to 102 cm H2O (mean: 68.8 cm H2O). Treatment was well tolerated in every case.


CONCLUSIONS
These preliminary results need to be completed by a randomized placebo-controlled study to confirm a statistically significant effect of Moxisylyte hydrochloride on urethral pressure stability in women presenting with urethral instability.
Combes
T
T
Institution Nationale des Invalides, Paris.
Beguin
A M
AM
Coulomb
Y
Y
Barouti
H
H
Costa
P
P
D000328:Adult; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D013948:Moxisylyte / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D011141:Polyuria / Q000188:drug therapy; D011312:Pressure; D016032:Randomized Controlled Trials as Topic; D014521:Urethra / Q000187:drug effects* / Q000503:physiopathology*; D014522:Urethral Diseases / Q000188:drug therapy*; D014549:Urinary Incontinence / Q000188:drug therapy; D014555:Urination Disorders / Q000188:drug therapy*; D014563:Urodynamics / Q000187:drug effects
D010919:Placebos; D013948:Moxisylyte
Evolution des pressions urétrales après injection intraveineuse de chlorhydrate de Moxisylyte dans l'instabilité urétrale de la femme. Résultats préliminaires.