title: Functional and mobility impairments associated with Paget's disease of bone.
abstract: OBJECTIVE
  To determine if patients with Paget's disease of bone involving the tibia, femur, and/or acetabular portion of the ilium had more impairments in function and mobility than age- and sex-matched control subjects.
  
  
  METHODS
  A case control study with Paget's disease patients selected from a center for bone disease at a tertiary medical center; control subjects were volunteers from the Duke University Aging Center subject registry. Demographic characteristics, physical examination and serum alkaline phosphatase levels were obtained. Radiographs of the pelvis and lower extremities were evaluated by a radiologist. All participants completed a Functional Status Questionnaire (FSQ). Mobility measures included mobility skills protocol, 10-foot walk time, 360-degree turn left (number of steps), and 6-minute walk distance.
  
  
  RESULTS
  The 12 Paget's disease patients were no different in age (70.7 +/- 6.2 years) than the 12 control subjects (69.5 +/- 6.2 years). Serum alkaline phosphatase levels were elevated in Paget's patients (539 +/- 530 IU/L), and normal in control subjects (85 +/- 17 IU/L). In addition to Paget's disease, radiographs showed joint space loss in joints proximate to the diseased bone. On the FSQ scales Paget's disease patients had significantly lower scores in basic activities of daily living (P < .05), instrumental activities of daily living (P < .001), and social activity than control subjects (P < .05). There was no difference between the groups on scales measuring mental health and quality of social interaction. On mobility measurements, Paget's disease patients showed significant impairments when compared with control subjects: mobility skills protocol score (22.5 +/- 2.5 vs 25.6 +/- 0.7, P < .001); 10-foot walk (3.96 +/- 1.3 vs 2.55 +/- 0.5 seconds, P < .001); 360 degree turn left (8.0 +/- 1.0 vs 5.9 +/- 0.6 steps, P < .001); and 6-minute walk (342.0 +/- 108.5 vs 519.4 +/- 100 meters, P < .001).
  
  
  CONCLUSIONS
  When compared with control subjects, patients who have Paget's disease of bone involving the tibia, femur, or acetabular portion of the ilium have clinically and statistically significant functional and mobility impairments compared to age- and gender-matched controls.
authors.affiliation: Department of Medicine, Duke University, Durham, North Carolina, USA.
authors.forename: K W
authors.initials: KW
authors.lastname: Lyles
authors.forename: J E
authors.initials: JE
authors.lastname: Lammers
authors.forename: K M
authors.initials: KM
authors.lastname: Shipp
authors.forename: L
authors.initials: L
authors.lastname: Sherman
authors.forename: C F
authors.initials: CF
authors.lastname: Pieper
authors.forename: S
authors.initials: S
authors.lastname: Martinez
authors.forename: D T
authors.initials: DT
authors.lastname: Gold
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000201:enzymology / Q000503:physiopathology*; D012647:Self-Assessment
chemical_list: D000469:Alkaline Phosphatase