title: Intrinsic and extrinsic characteristics of human tumors relevant to radiosurgery: comparative cellular radiosensitivity and hypoxic percentages.
abstract: We have collected the in vitro x-ray radiation survival characteristics of 181 lines from 12 different classes of exponentially growing human tumor cells (sarcomas, lung cancers, colo-rectal cancers, medulloblastomas, melanoma, breast cancers, prostate cancers, renal cell cancers, grades III and IV brain tumors, ovarian, and head and neck cancers). This information was used to intercompare survival after single high doses of 20-40 Gy for each tumor line. Radiosensitivities could roughly be divided into two groups. The more radiosensitive group included: sarcoma, small-cell lung cancer, non-small cell lung cancer, colorectal cancer, medulloblastoma and melanoma. The more radioresistant group included breast, prostate, renal cell, primary brain tumors, ovarian tumors, and head and neck cancers. Using a model of a 3 cm diameter brain lesion containing about 1.4 x 10(9) oxic cells, the single doses calculated to reduce survival to 1 cell were: sarcoma and small cell lung cancers-22-23 Gy; melanoma-25 Gy; non-small cell lung and colorectal cancer-26 Gy; medullo-blastoma-28 Gy; breast, prostate, renal cell, primary brain tumors, ovarian tumors, and head and neck cancers-30-36 Gy. If, however, tumors contained on average 20 percent hypoxic cells, the dose needed for equivalent cell killing increased by about a factor of 2.6-2.8. Also, there was no correlation between the ranking of relative radiosensitivities of the various classes of tumor cells at high doses (as in radiosurgery) to the sensitivity at low doses (as in conventional fractionated radiotherapy).
  
  
  CONCLUSIONS
  available information on the intrinsic radiosensitivity of human tumor cells indicates that meaningful differences exist among different histological classes of neoplasm that are relevant to the single high doses used in radioneurosurgery, and which could constitute a basis for "tailoring" the administered dose to the particular neoplasm. However, if intracerebral lesions contain a large number of hypoxic cells (e.g., 20%), this may constitute a significant problem.
authors.affiliation: Department of Radiation Medicine, Brown University, Providence, RI, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Leith
authors.forename: S
authors.initials: S
authors.lastname: Cook
authors.forename: P
authors.initials: P
authors.lastname: Chougule
authors.forename: P
authors.initials: P
authors.lastname: Calabresi
authors.forename: L
authors.initials: L
authors.lastname: Wahlberg
authors.forename: C
authors.initials: C
authors.lastname: Lindquist
authors.forename: M
authors.initials: M
authors.lastname: Epstein
mesh_terms: D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D000860:Hypoxia; D066298:In Vitro Techniques; D009369:Neoplasms / Q000601:surgery*; D011829:Radiation Dosage; D011836:Radiation Tolerance; D016634:Radiosurgery; D015996:Survival Rate