title: Clinical significance of creatine kinase isoenzymes for fetal asphyxia in women at labor.
abstract: Creatine kinase-brain isoenzyme activity (CK-BB) was measured longitudinally in the serum of 31 pregnant women in the first stage of labor (early and advanced), at delivery, and 1, 6 and 24 h after delivery, in the umbilical cord and in the serum of their neonates on the first day of life. There was no increase in serum CK-BB values of mothers that delivered normally (n = 15) or had an elective cesarean section (n = 5). Pregnant women with signs of fetal distress had an increase in CK-BB levels in the first stage of labor (mean +/- SD 4.5 +/- 4.9 U/l, p < 0.03) and 6 h after delivery (12 +/- 4 U/l, p < 0.0001). Neonates with intrauterine stress also had an increase in their CK-BB to 144 +/- 116 U/l at 6 h of life, in comparison with babies born without signs of stress. It appears that CK-BB during labor and in the first hours of life may be indicative of intrauterine stress.
authors.affiliation: Child Health Department, University of Ioannina Medical School, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Andronikou
authors.forename: E
authors.initials: E
authors.lastname: Bairaktari
authors.forename: A D
authors.initials: AD
authors.lastname: Vasiliadou
authors.forename: T
authors.initials: T
authors.lastname: Stefos
authors.forename: D
authors.initials: D
authors.lastname: Lolis
authors.forename: O
authors.initials: O
authors.lastname: Tsolas
authors.forename: P D
authors.initials: PD
authors.lastname: Lapatsanis
mesh_terms: D001238:Asphyxia Neonatorum / Q000201:enzymology*; D002585:Cesarean Section; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D005316:Fetal Distress / Q000201:enzymology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes; D007743:Labor, Obstetric / Q000097:blood; D011247:Pregnancy; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase