title: A comparison of the accumulation of novobiocin into bacteria with its antibacterial properties.
abstract: The accumulation of novobiocin in bacteria has been compared with the MIC, inhibition of DNA biosynthesis and inhibition of the activity of isolated DNA gyrase for a range of species. There was a good correlation between MIC and the inhibition of DNA biosynthesis and DNA gyrase. Novobiocin accumulation did not correlate with any other parameter.
authors.affiliation: Infection Research Department, Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK.
authors.forename: K
authors.initials: K
authors.lastname: Barrett-Bee
authors.forename: P
authors.initials: P
authors.lastname: Pinder
authors.forename: J
authors.initials: J
authors.lastname: Stawpert
mesh_terms: D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D004264:DNA Topoisomerases, Type I / Q000187:drug effects; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009675:Novobiocin / Q000494:pharmacology*; D010539:Permeability
chemical_list: D004269:DNA, Bacterial; D009675:Novobiocin; D004264:DNA Topoisomerases, Type I