Pure FSH (Metrodin) for ovarian stimulation in the IVF-ET programme.
OBJECTIVE
a comparative analysis of the clinical effectiveness of pure FSH (Metrodin) and conventional gonadotropin (Pergonal) for ovarian stimulation was performed.


METHODS
each group consisted of 30 selected patients with tubal infertility, practically identical by average age, duration of infertility, age at menarche, weight and height and husband's semen analysis. The average number of vials of drug used for stimulation, number of oocytes retrieved and embryos transferred was the same for both groups of patients. The failure of oocyte retrieval and fertilization was higher in the Pergonal (16.8%) than in the Metrodin group (6.8%).


RESULTS
in both groups there were 8 pregnancies--4 in the Pergonal and 4 in Metrodin group. All pregnancies in the pure FSH group resulted in the delivery of a healthy baby, while in the Pergonal group there were two deliveries and two spontaneous abortions.


CONCLUSIONS
evaluating the data we can conclude that pure FSH stimulation provides respectively lower failure and spontaneous abortion rates than Pergonal stimulation, leading to a higher take home baby rate.
Meden-Vrtovec
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University Department of Obstetrics and Gynecology, Ljubljana, Slovenia.
D000293:Adolescent; D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D008596:Menotropins / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects*; D012099:Reproductive Techniques; D016896:Treatment Outcome
D008596:Menotropins; D005640:Follicle Stimulating Hormone