[Effect of long-term administration of undevit and its combination with cordiamine on hydroxylation, glucuronidation and glutathione conjugation systems and lipid peroxidation in rat liver].
Increase of N-demethylase and antioxidant activities and decrease of amount of hydroperoxides were observed in liver of rats after intragastric administration of Undevit (1/8 dragee/rats/day, 5 times a week during 2 months). Combination of Undevit with Cordiamin (5 mg/rat/day) resulted in augmentation of cytochromes P-450 and b5 content and activities of their reductases, velocity of amidopyrine and ethylmorphine N-demethylation and oxidation of HADPH. Activities of UDP-glucuronyltransferase, glutathionetransferase and hydrophobity of microsomal membranes were also increased. Antioxidant activity was increased and amount of hydroperoxides in liver microsomes and homogenates and in plasma was decreased in greater degree after administration of combination two compounds than after administration of Undevit alone.
Bushma
M I
MI
Legonkova
L F
LF
Abakumov
G Z
GZ
Zavodnik
L B
LB
D000284:Administration, Oral; D000633:Aminopyrine N-Demethylase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism; D015786:Cytochromes b5 / Q000187:drug effects / Q000378:metabolism; D004359:Drug Therapy, Combination; D005037:Ethylmorphine-N-Demethylase / Q000187:drug effects / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000187:drug effects / Q000378:metabolism; D005982:Glutathione Transferase / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D009252:NADPH Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D009552:Nikethamide / Q000494:pharmacology*; D009930:Organic Chemicals; D051381:Rats; D013997:Time Factors; D014815:Vitamins / Q000494:pharmacology*
D009930:Organic Chemicals; D014815:Vitamins; D009552:Nikethamide; C043234:undevit; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; D005037:Ethylmorphine-N-Demethylase; D009252:NADPH Dehydrogenase; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase
Vliianie dlitelńogo vvedeniia undevita i ego kombinatsii s kordiaminomna gidroksiliruiushchuiu, gliukuro-, glutationkoníugiruiushchuiu sistemy i perekisnoe okislenie lipidov pecheni intaktnykh krys.