title: Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones as potential platelet aggregation inhibitors.
abstract: Twenty new compounds having 2-methyl-6-benzylidenethiazolo[3,2-b]- 1,2,4-triazole-5(6H)-one (2a-d) and 2-methyl-6-(alpha-aminobenzyl)thiazolo-[3,2-b]-1,2,4- triazole-5-ol (5-20) structures were synthesized. Their structures were confirmed by elemental and spectroscopic analysis and their platelet aggregation inhibitory activities were investigated.
authors.affiliation: Hacettepe University, Faculty of Pharmacy, Dept. of Pharmaceutical Chemistry, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Tozkoparan
authors.forename: H
authors.initials: H
authors.lastname: Akgün
authors.forename: M
authors.initials: M
authors.lastname: Ertan
authors.forename: K
authors.initials: K
authors.lastname: Rübsemann
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D013844:Thiazoles; D014230:Triazoles