title: The role of Ig beta in precursor B cell transition and allelic exclusion.
abstract: Lymphocytes express multicomponent receptor complexes that mediate diverse antigen-dependent and antigen-independent responses. Despite the central role of antigen-independent events in B cell development, little is known about the mechanisms by which they are initiated. The association between the membrane immunoglobulin (Ig) M heavy chair (micron) and the Ig alpha-Ig beta heterodimer is now shown to be essential in inducing both the transition from progenitor to precursor B cells and subsequent allelic exclusion in transgenic mice. The cytoplasmic domain of Ig beta is sufficient to induce these early antigen-independent events by a mechanism that requires conserved tyrosine residues in this protein.
authors.affiliation: Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA.
authors.forename: F
authors.initials: F
authors.lastname: Papavasiliou
authors.forename: Z
authors.initials: Z
authors.lastname: Misulovin
authors.forename: H
authors.initials: H
authors.lastname: Suh
authors.forename: M C
authors.initials: MC
authors.lastname: Nussenzweig
mesh_terms: D000483:Alleles; D000818:Animals; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D051925:CD79 Antigens; D005803:Genes, Immunoglobulin; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D011995:Recombination, Genetic; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D051925:CD79 Antigens; C497881:CD79A protein, human; C497882:Cd79a protein, mouse; D007148:Immunoglobulin mu-Chains; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D011947:Receptors, Antigen, B-Cell; D014443:Tyrosine