title: Systemic mastocytosis associated with chronic myelomonocytic leukemia: clinical features and response to interferon alfa therapy.
abstract: Systemic mastocytosis is a rare disease that shows marked heterogeneity in clinical manifestations and prognosis. It may be associated with hematologic disorders. We describe a patient with systemic mastocytosis associated with chronic myelomonocytic leukemia accompanied by ascites, pleural effusion, and development of skin lesions along a surgical scar. The disease responded well to interferon alfa therapy. This is the second report of successful treatment of mastocytosis with interferon alfa and the first associated with a hematologic malignancy.
authors.affiliation: Department of Dermatology, Centre Hospitalier Victor Dupouy, Argenteuil, France.
authors.forename: A
authors.initials: A
authors.lastname: Petit
authors.forename: M
authors.initials: M
authors.lastname: Pulik
authors.forename: A
authors.initials: A
authors.lastname: Gaulier
authors.forename: F
authors.initials: F
authors.lastname: Lionnet
authors.forename: A
authors.initials: A
authors.lastname: Mahe
authors.forename: M
authors.initials: M
authors.lastname: Sigal
mesh_terms: D001201:Ascites / Q000150:complications; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000150:complications; D016898:Interferon-alpha / Q000627:therapeutic use*; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications*; D008415:Mastocytosis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000150:complications
chemical_list: D016898:Interferon-alpha