title: The effect of peep-ventilation on cardiac function in closed chest pigs.
abstract: OBJECTIVE
  Does ventilation with positive end-expiratory pressure (PEEP) depress myocardial contractility?
  
  
  METHODS
  Ten piglets were anaesthetized and prepared for the measurement of cardiac output (SV) and right (MRAPtm) and left (MLAPtm) mean transmural atrial pressure, the latter serving as indices of preload. 500 ml of autologous blood was re-transfused during intermittent positive pressure ventilation without PEEP (IPPV) and continuous positive pressure ventilation with 15 cm H2O PEEP (CPPV).
  
  
  RESULTS
  Right and left ventricular function curves were drawn by plotting MRAPtm and MLAPtm respectively versus the corresponding strokevolumes before and after re-transfusion. Similar inclinations were obtained during IPPV and CPPV on either side of the heart.
  
  
  CONCLUSIONS
  Although the ventricular function curves during IPPV and CPPV covered partially different preload levels, the results suggest that CPPV i.e. PEEP does not affect myocardial contractility.
authors.affiliation: Department of Anaesthesiology and Intensive Care, University Hospital, Uppsala, Sweden.
authors.forename: J E
authors.initials: JE
authors.lastname: Berglund
authors.forename: E
authors.initials: E
authors.lastname: Haldén
authors.forename: S
authors.initials: S
authors.lastname: Jakobson
mesh_terms: D000818:Animals; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D008297:Male; D009200:Myocardial Contraction; D011175:Positive-Pressure Respiration; D013552:Swine