Role of antibodies against fibronectin-, collagen-binding proteins and alphatoxin in experimental Staphylococcus aureus peritonitis and septicaemia in neutropenic mice.
We have investigated the protective role of hyperimmune rabbit IgG against two surface structures of Staphylococcus aureus, i.e. fibronectin-, and collagen-binding proteins as well as alpha-toxin in experimental peritonitis and septicaemia in neutropenic mice pretreated with cyclophosphamide. This treatment markedly decreased clearance of bacteria from mouse organs. With combined immunotherapy given passively bacteria were eradicated more efficiently for all animals sampled, comparative to controls.
Rozalska
B
B
Department of Medical Microbiology, University of Lund, Sweden.
Wadström
T
T
D018829:Adhesins, Bacterial; D000818:Animals; D016470:Bacteremia / Q000517:prevention & control*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001426:Bacterial Proteins; D002352:Carrier Proteins; D007116:Immunization, Passive; D016023:Integrins / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009503:Neutropenia / Q000150:complications*; D010538:Peritonitis / Q000517:prevention & control*; D011817:Rabbits; D038981:Receptors, Collagen; D013203:Staphylococcal Infections / Q000517:prevention & control*
D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D016023:Integrins; D038981:Receptors, Collagen; C078635:fibronectin-binding proteins, bacterial