title: Helical growth of hyphae of Candida albicans.
abstract: When grown on a range of surfaces in conditions favouring hyphal growth, hyphae of Candida albicans grew in a right-handed helical fashion. This phenomenon was observed with eight strains and with two nutrient media. It is suggested that this is a result of rotation of the hyphal apex as it extends, which on some surfaces results in a helical hyphal wall, but which in a liquid results in a straight hypha. The consequence is that on a surface, a helically growing hypha will be exposed to a more diverse environment than a straight hypha. This phenomenon may have significance in the colonization of tissue by C. albicans.
authors.affiliation: Department of Molecular and Cell Biology, Marischal College, University of Aberdeen, UK.
authors.forename: J
authors.initials: J
authors.lastname: Sherwood-Higham
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhu
authors.forename: C A
authors.initials: CA
authors.lastname: Devine
authors.forename: G W
authors.initials: GW
authors.lastname: Gooday
authors.forename: N A
authors.initials: NA
authors.lastname: Gow
authors.forename: D W
authors.initials: DW
authors.lastname: Gregory
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D002455:Cell Division / Q000187:drug effects; D054714:Echinocandins; D005656:Fungal Proteins; D010455:Peptides; D010456:Peptides, Cyclic / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D010455:Peptides; D010456:Peptides, Cyclic; C042101:cilofungin; C007572:echinocandin B