title: A variant t(14;17) in acute promyelocytic leukemia. Positive response to retinoic acid treatment.
abstract: We present a case of acute promyelocytic leukemia (APL) carrying an atypical translocation involving chromosomes 14 and 17. This translocation could be considered a variant of the APL-specific t(15;17). Positive response to retinoic acid treatment suggests molecular rearrangement of retinoic acid receptor alpha.
authors.affiliation: Department of Genetics, University of Navarra, Pamplona, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Cigudosa
authors.forename: M J
authors.initials: MJ
authors.lastname: Calasanz
authors.forename: M D
authors.initials: MD
authors.lastname: Odero
authors.forename: J
authors.initials: J
authors.lastname: Marín
authors.forename: E
authors.initials: E
authors.lastname: Bengoechea
authors.forename: A
authors.initials: A
authors.lastname: Gullón
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D003131:Combined Modality Therapy; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy; D008297:Male; D012074:Remission Induction; D014178:Translocation, Genetic; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin