title: Case report of a patient with multiple lesions of the stomach, including multiple cancers and an adenomatous polyp.
abstract: This paper describes an unusual case of an 80-year-old man followed up for multifocal gastric cancers. There were three separate polypoid carcinomas and one adenomatous polyp with no sign of malignancy. We measured the DNA content of the gastric cancer and adenomatous cells obtained from endoscopically biopsied specimens. The adenomatous polyp and one of the cancerous lesions showed DNA diploidy. The other two cancerous lesions showed DNA aneuploidy, with different DNA index (DI) values (1.12 and 1.64, respectively). It is considered that the three cancers arose from different stem lines. However, an operation was not performed because the patient refused gastrectomy, and therefore only conservative follow up has been continued. Presentation of this case is followed by a detailed discussion focusing on the possible development of carcinoma in gastric adenomatous polyps in view of the data from the literature.
authors.affiliation: Department of Gastroenterology, Keiju Hospital, Ishikawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Kanno
authors.forename: H
authors.initials: H
authors.lastname: Takamura
authors.forename: H
authors.initials: H
authors.lastname: Arakawa
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Uogishi
authors.forename: H
authors.initials: H
authors.lastname: Sodani
authors.forename: A
authors.initials: A
authors.lastname: Kawashima
mesh_terms: D018256:Adenomatous Polyps / Q000737:chemistry / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D004171:Diploidy; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000737:chemistry; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm