[Apoptosis or programmed cell death: regulatory and pathophysiological mechanisms].
Apoptosis is an active death process genetically encoded to eliminate abnormal or unwanted cells. The phenomenon is induced by a cascade of molecular events leading to nucleolysis by endonucleases and involves a number of membrane receptors and cytoplasmic proteins. These structures (including Fas, müllerian inhibiting substance, p53 and the c-myc oncogene) contribute, by interactive regulatory mechanisms, to the promotion or inhibition of apoptosis, on the basis of both external stimulus and cell activation state. Since apoptosis is a selective process to suppress defective cells, deregulation of genes encoding for such apoptosis-related proteins could be relevant in the growth of several tumors. Remarkably, overexpression of the bcl-2 gene in a few experimental lymphomas has been associated with neoplastic proliferation because of its inhibitory effect on apoptosis. Conversely, early activation of Fas, an apoptosis-inducing gene on HIV-infected CD4+ lymphocytes, is thought to aggravate T cell lymphopenia in HIV infection by increasing the level of normal apoptosis. Genetic deregulation of apoptosis has also been postulated in the pathogenesis of several diseases. Indeed, while preliminary studies suggest that apoptosis plays a role in autoimmune disorders including systemic lupus erythematosus, the pathogenesis of a few degenerative neuropathies, such as Alzheimer's disease, could depend on a similar altered mechanism in apoptosis of neuronal cells. However, no studies are presently available to suggest that exploitation of molecular events of apoptosis would imply therapeutic progress.
Silvestris
F
F
Ribatti
D
D
Nico
B
B
Silvestris
N
N
Romito
A
A
Dammacco
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000473:pathology; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology; D017209:Apoptosis / Q000235:genetics* / Q000502:physiology*; D001327:Autoimmune Diseases / Q000235:genetics / Q000473:pathology; D003907:Dexamethasone / Q000494:pharmacology; D004720:Endonucleases / Q000378:metabolism; D004789:Enzyme Activation; D016259:Genes, myc; D016355:Genes, pX; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology
D003907:Dexamethasone; D004720:Endonucleases
Apoptosi, o morte cellulare programmata: meccanismi regolatori e fisiopatologia.