MRI evaluation of potential gastrointestinal contrast media.
Diluted ProHance [Gd(HP-DO3A), Squibb Diagnostics, Princeton, NJ], Sustacal (Meadjohnson, Evansville, IN), a nutritional drink, and a ProHance/Sustacal mixture have been investigated as potential oral contrast agents. At 2 T, T1-weighted (SE 500/20) images demonstrated hyperintense (positive) signal enhancement of rat GI tracts within 10 min after the ingestion of 2.0 mM Gd(HP-DO3A) or 2.0 mM ProHance/Sustacal. T2-weighted (SE 3000/80) images demonstrated hypointense (negative) signal intensity within 10 min after ingestion of 10 mM ProHance. Medical imaging applications of these oral contrast media are feasible.
Wan
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Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
Wedeking
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P
Tweedle
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D000818:Animals; D003287:Contrast Media; D004064:Digestive System / Q000033:anatomy & histology*; D005240:Feasibility Studies; D005526:Food, Formulated; D005682:Gadolinium; D006571:Heterocyclic Compounds; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds; D051381:Rats
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium