title: [Prophylactic antibiotic therapy with amoxicillin-clavulanic acid in oropharyngeal surgery].
abstract: The present paper shows the results of a randomized, prospective trial carried out on 170 patients undergoing elective surgery for oropharyngeal cancer. These patients were distributed in two groups that received a prophylactic therapy with amoxicillin and clavulanic acid, for 24 hours and 5 days, respectively. Comparing results of short-term and long-term prophylaxis. Among patients undergoing only total or partial laryngectomies, no differences between both groups were found. Among patients who already had a tracheostomy, the rate of local infection was higher in the short-time group. Duration of prophylaxis in high-risk surgery, such as that requiring flap reconstruction, needs further investigation.
authors.affiliation: Servicio de ORL. Hospital Gregorio, Marañón, Madrid.
authors.forename: M
authors.initials: M
authors.lastname: Navarro
authors.forename: E
authors.initials: E
authors.lastname: Scola
authors.forename: B
authors.initials: B
authors.lastname: Scola
authors.forename: P
authors.initials: P
authors.lastname: Ortiz
authors.forename: T
authors.initials: T
authors.lastname: Martínez
authors.forename: M F
authors.initials: MF
authors.lastname: Vega
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D006801:Humans; D007825:Laryngectomy; D009959:Oropharyngeal Neoplasms / Q000601:surgery*; D011292:Premedication; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors; D014140:Tracheotomy; D065093:beta-Lactamase Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D000658:Amoxicillin
vernacular_title: Antibioterapia profiláctica con amoxicilina-clavulánico en cirugía orofaringolaríngea.