Multipoint interval mapping of quantitative trait loci, using sib pairs.
The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.
Fulker
D W
DW
Institute for Behavioral Genetics, University of Colorado, Boulder 80309-0447, USA.
Cherny
S S
SS
Cardon
L R
LR
D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D005819:Genetic Markers; D006801:Humans; D008957:Models, Genetic; D009679:Nuclear Family; D013223:Statistics as Topic / Q000379:methods; D013997:Time Factors
D005819:Genetic Markers