Localization of the murine homolog of the anaplastic lymphoma kinase (AlK) gene on mouse chromosome 17.
The murine homolog of the human anaplastic lymphoma kinase gene, which encodes a membrane-spanning receptor tyrosine kinase in the insulin receptor kinase subfamily, was assigned to mouse Chromosome 17 by interspecific backcross analysis. This assignment further confirms the homology between a portion of the distal Chromosome 17 and the short arm of human chromosome 2 and extends this region in the mouse by an additional 3 cM.
Mathew
P
P
Department of Experimental Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101-0318, USA.
Morris
S W
SW
Kane
J R
JR
Shurtleff
S A
SA
Pasquini
M
M
Jenkins
N A
NA
Gilbert
D J
DJ
Copeland
N G
NG
D000077548:Anaplastic Lymphoma Kinase; D000818:Animals; D002874:Chromosome Mapping / Q000662:veterinary; D005260:Female; D008297:Male; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D009115:Muridae; D012150:Polymorphism, Restriction Fragment Length; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases
C000626173:ALK protein, human; C000626174:Alk protein, mouse; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases