title: Microscopic haematuria as a relative contraindication for tranexamic acid.
abstract: Tranexamic acid has been advocated for patients with severe bleeding tendency due to thrombocytopenia not responding to platelet transfusions. Macroscopic haematuria is a well-known contraindication for its use in such patients. We present three clinical cases with microscopic haematuria, in whom tranexamic acid caused problems of clot formation in the urinary tract, indicating that microscopic haematuria should also be considered as a contraindication for tranexamic acid.
authors.affiliation: Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Schultz
authors.forename: H
authors.initials: H
authors.lastname: van der Lelie
mesh_terms: D000328:Adult; D000075202:Contraindications; D005260:Female; D006417:Hematuria / Q000209:etiology*; D006474:Hemorrhagic Disorders / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000188:drug therapy; D013927:Thrombosis / Q000209:etiology; D014148:Tranexamic Acid / Q000009:adverse effects; D014517:Ureteral Obstruction / Q000209:etiology*; D014524:Urethral Obstruction / Q000209:etiology*
chemical_list: D014148:Tranexamic Acid