The deafness locus (dn) maps to mouse chromosome 19.
The deafness mouse has profound sensorineural hearing loss with degeneration of hair cells soon after birth. The mode of inheritance is recessive, and there are no associated phenotypic anomalies. Thus, this mouse provides a model for recessive, non-syndromic, prelingual deafness. We have mapped the gene causing deafness in the mouse to Chromosome (Chr) 19 by analysis of 230 intersubspecific backcross progeny. No recombinants were found with the microsatellite marker D19Mit14. The loci for two guanine nucleotide-binding proteins are tightly linked to this marker, and they are being investigated as possible candidate genes. The identification of the defective gene in the mouse will help to explain the mechanism that causes hair cell degeneration and is likely to identify a homologous gene for deafness in humans.
Keats
B J
BJ
Department of Biometry and Genetic, Kresge Hearing Research Laboratory, Louisiana State University Medical Center, New Orleans 70112.
Nouri
N
N
Huang
J M
JM
Money
M
M
Webster
D B
DB
Berlin
C I
CI
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003638:Deafness / Q000235:genetics*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics; D005808:Genes, Recessive; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D009115:Muridae / Q000235:genetics; D012021:Reflex, Abnormal; D013045:Species Specificity
D019204:GTP-Binding Proteins