Influence of NMDA receptor ligands on thyrotropin-releasing hormone-induced scratching in rabbits.
The influence of intracaudate administration of N-methyl-D-aspartic acid (NMDA) and of the competitive NMDA receptor antagonist, DL-2-amino-5-phosphonovaleric acid (AP-5) was studied on thyrotropin-releasing hormone (TRH)-induced scratching in rabbits. NMDA (28 nmol) significantly increased the latency of TRH-induced scratching but did not modify the duration of this behaviour. Conversely, AP-5 (0.5 mumol) significantly potentiated scratching duration. Since TRH-induced scratching has been reported to be a dopamine-dependent behaviour, these results suggest that NMDA receptor ligands modulate dopaminergic neurotransmission.
Popoli
P
P
Pharmacology Department, Istituto Superiore di Sanità, Rome, Italy.
Caporali
M G
MG
Scotti de Carolis
A
A
D015763:2-Amino-5-phosphonovalerate / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001667:Binding, Competitive; D002421:Caudate Nucleus / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008024:Ligands; D008297:Male; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000633:toxicity*
D008024:Ligands; D016194:Receptors, N-Methyl-D-Aspartate; D013973:Thyrotropin-Releasing Hormone; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D004298:Dopamine