[Prophylactic effect of systemic ceftazidime on bacterial translocation in scalded rats].
In this study, we evaluated the prophylactic effect of Ceftazidime on bacterial translocation (BT) of Pseudomonas aeruginosa in scalded rat by qualitative and quantitative bacterial cultures of blood, organs and mesenteric lymph nodes (MLN). Ceftazidi-me was administered systemically at 3 h, 6 h and 12 h post injury respectively. The dynamic changes in levels of Ceftazidime in blood and organ tissues were also determined. The results showed that effective levels of Ceftazidime in blood, liver and mucosa of the small intestine were rapidly reached and maintained for more than 4 h, but no drug was found in MLN. The prophylactic effect on BT was significant when systemic administration started at 3 h post injury (P < 0.001) and 6 h post injury (P < 0.05). Although the incidence of BT was unchanged (P > 0.05) when systemic administration started at 12 h, the number of organisms present in livers and kidneys, except MLN, was dramatically reduced (P < 0.01).
Zong
G
G
Department of Surgery, 81 Hospital of People's Liberation Army, Nanjing.
Xiao
G
G
Zhang
Y
Y
D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000382:microbiology*; D002442:Ceftazidime / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D008297:Male; D011552:Pseudomonas Infections / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014781:Viscera / Q000382:microbiology
D002442:Ceftazidime