[Effect of an extract prepared from "dai-bofu-to" on morphine withdrawal responses].
A water-extract (TJ-97) prepared from "Dai-bofu-to", a "Kampo" medicine (Chinese traditional prescriptions composed of herbal drugs) was tested for its potency to modulate morphine withdrawal responses in animals. TJ-97 significantly attenuated naloxone-induced contraction of the segments of the ileum isolated from morphine-dependent guinea pigs in the absence and presence of atropine. TJ-97 also inhibited the contractile responses of the segments to electrical field stimulation at a low frequency and those to nicotine, but not those to exogenously applied ACh or substance P. The rats given i.p. TJ-97 and 30 min later challenged with naloxone showed significantly lowered frequency of excretion and diminished amount of feces, including soft stools (diarrhea), as compared with the saline-injected control rats. These findings suggest that TJ-97 inhibits the release of ACh and substance P or substance P-like peptide(s) from the nervous structures in the wall of the ileum.
Takamura
S
S
Department of Pharmacology, Kanazawa Medical University, Ishikawa, Japan.
Yoshida
J
J
Suzuki
S
S
D000818:Animals; D003864:Depression, Chemical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000294:innervation; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009119:Muscle Contraction / Q000187:drug effects; D009270:Naloxone / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome
D004365:Drugs, Chinese Herbal; C093448:dai-bofu-to; D009270:Naloxone; D009020:Morphine