title: [Progression of HIV infection in a cohort of hemophiliacs over an 11-year period].
abstract: BACKGROUND
  The progression of HIV infection in a cohort of hemophiliacs was evaluated taking into consideration the particularities of the natural history of HIV in this population and comparing the same with that described for other series of hemophiliacs and other risk groups for HIV infection.
  
  
  METHODS
  A cohort of 141 hemophiliac patients with HIV infection controlled in a Hemophilia Unit since January 1983 was studied. The accumulated incidence of AIDS and the mortality at 11 years of follow up were evaluated. Likewise, the association of prognostic factors such as age, type of hemophilia or previous treatment with antihemophilic factors were evaluated.
  
  
  RESULTS
  The accumulated incidence of AIDS at the end of follow up was 56% with a mortality rate of 33%. The evolution showed statistically significant differences with regard to age (p = 0.00048) and previous treatment (p = 0.00239). No differences were observed concerning the type of hemophilia or its severity.
  
  
  CONCLUSIONS
  HIV infection in the cohort of hemophiliacs studied presented similar accumulated AIDS incidence and mortality to those described in other series of hemophiliacs. These values are apparently more favorable than those referred for other risk groups, possibly due to the particular epidemiologic characteristics.
authors.affiliation: Unidad de Hemofilia, Hospital General Universitari Vall d'Hebron, Barcelona.
authors.forename: C
authors.initials: C
authors.lastname: Altisent Roca
authors.forename: A
authors.initials: A
authors.lastname: Ayestarán Altuna
authors.forename: J M
authors.initials: JM
authors.lastname: Tusell Puigbert
authors.forename: J
authors.initials: J
authors.lastname: Oliveras Martín
authors.forename: J B
authors.initials: JB
authors.lastname: Montoro Ronsano
authors.forename: M
authors.initials: M
authors.lastname: Vila Baucells
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000401:mortality; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000453:epidemiology* / Q000401:mortality; D006467:Hemophilia A / Q000150:complications* / Q000401:mortality; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors
vernacular_title: Progresión de la infección por el virus de la inmunodeficiencia humana en una cohorte de hemofílicos durante un período de 11 años.