Serological evidence of past hepatitis B infection in liver donor and hepatitis B infection in liver allograft.
The presence of hepatitis B surface and core antibodies (anti-HBs and anti-HBc) in a liver donor without hepatitis B surface antigen is taken to indicate resolution of hepatitis B and is not considered to contraindicate donation. We report a liver transplant recipient who developed hepatitis B after such a donation. It seems that hepatitis B virus can reside in the liver of a patient who has seemingly recovered from his disease. We recommend avoidance of liver transplants from donors who are positive for anti-HBs and anti-HBc.
Lowell
J A
JA
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.
Howard
T K
TK
White
H M
HM
Shenoy
S
S
Huettner
P C
PC
Brennan
D C
DC
Peters
M G
MG
D005260:Female; D006084:Graft Rejection; D006509:Hepatitis B / Q000175:diagnosis*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006511:Hepatitis B Antigens / Q000097:blood* / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D008099:Liver / Q000821:virology*; D008875:Middle Aged; D012698:Serologic Tests; D014019:Tissue Donors
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens