Immunological aspects of a case of posttransplant lymphoproliferative disorder.
We describe a female renal transplant recipient with cytomegalovirus and Epstein-Barr virus (EBV) infections who developed aggressive polymorphous polyclonal B cell proliferation. She received two courses of OKT3. We found a majority of transformed B cells bearing EBV membrane receptor CR2 and EBV nuclear antigen. Posttransplant lymphoproliferative disorders may be associated with a significant immunological activation, detected in this case by the sudden increase of beta 2-microglobulin and immunoglobulin levels, including immunoglobulin D. These raised levels persisted throughout the short and rapid course of the disease.
Franco
A
A
Department of Nephrology, General Hospital Alicante, Spain.
Muñoz
C
C
Aranda
I
I
Cabezas
A
A
Perdiguero
M
M
Prados
C
C
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000276:immunology*; D016853:Muromonab-CD3 / Q000627:therapeutic use; D011183:Postoperative Complications / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology
D007136:Immunoglobulins; D016853:Muromonab-CD3; D001613:beta 2-Microglobulin