title: Low incidence of childhood celiac disease in The Netherlands.
abstract: The incidence and prevalence of celiac disease vary internationally. We studied the incidence of identified cases of childhood celiac disease in six Dutch provinces that cover 47.9% of the surface area and 67.6% of the total population of The Netherlands. Children with celiac disease aged 0-14 y, diagnosed from January 1975 to January 1991, were traced by 1) contacting all pediatricians in this area, 2) examining the date of the Dutch National Medical Registration, and 3) investigating the membership records of the Dutch Celiac Disease Society. These data were cross-checked by the Dutch Network and National Database of Pathology. Of the 97.9% of pediatricians who answered our inquiry, 46.1% were treating celiac patients. A total of 342 celiac patients were identified. Informed consent that permitted examination of their medical files was given by 97.3% of the parents of the celiac children. The mean crude incidence rate of diagnosed childhood celiac disease, calculated per 1000 live births per year, was 0.18. However, a significant increase in reported incidence was demonstrated from 0.10 in 1976 to 0.32 in 1990. The best estimate, for the years 1985-1990, is 0.22/1000 live births, which is much lower than in most European countries.
authors.affiliation: Department of Pediatrics, University Hospital Leiden, The Netherlands.
authors.forename: E K
authors.initials: EK
authors.lastname: George
authors.forename: M L
authors.initials: ML
authors.lastname: Mearin
authors.forename: E A
authors.initials: EA
authors.lastname: van der Velde
authors.forename: R H
authors.initials: RH
authors.lastname: Houwen
authors.forename: J
authors.initials: J
authors.lastname: Bouquet
authors.forename: C F
authors.initials: CF
authors.lastname: Gijsbers
authors.forename: J P
authors.initials: JP
authors.lastname: Vandenbroucke
mesh_terms: D000293:Adolescent; D001706:Biopsy / Q000706:statistics & numerical data; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006681:HLA-D Antigens / Q000032:analysis; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007421:Intestine, Small / Q000473:pathology; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence
chemical_list: D006681:HLA-D Antigens