Stimulation of penetrating corneal wound healing by exogenous fibronectin.
The paper describes the effect of exogenous fibronectin administered by instillation on the repair of the rabbit cornea after experimental mechanical injury. The effect was monitored by light microscopy and radioautography. Fibronectin had a beneficial effect on regenerating corneal epithelium, endothelium and keratocytes through a stimulatory effect on cell migration, proliferation and differentiation.
Gundorova
R A
RA
Moscow Helmholtz Research Institute of Eye Diseases, Russia.
Brikman
I V
IV
Ibadova
S I
SI
Issaeva
R T
RT
D000287:Administration, Topical; D000818:Animals; D001345:Autoradiography; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D065306:Corneal Injuries; D004261:DNA Replication / Q000187:drug effects; D004195:Disease Models, Animal; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D015807:Eye Injuries, Penetrating / Q000188:drug therapy* / Q000473:pathology; D005353:Fibronectins / Q000008:administration & dosage / Q000494:pharmacology*; D009883:Ophthalmic Solutions; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D005353:Fibronectins; D009883:Ophthalmic Solutions