THC-induced place and taste aversions in Lewis and Sprague-Dawley rats.
The hedonic properties of delta-9-tetrahydrocannabinol (THC) were assessed in place and taste conditioning paradigms in both Lewis and Sprague-Dawley rat strains. THC produced place avoidance, taste avoidance, and aversive taste reactivity responses in both strains. The Lewis strain displayed more aversive taste reactions and a stronger taste avoidance when conditioned with lower doses of THC than did the Sprague-Dawley strain of rats. THC is an anomalous drug of abuse that appears to be aversive to rats when assessed by these measures.
Parker
L A
LA
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Gillies
T
T
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology*; D008297:Male; D009042:Motivation; D009949:Orientation / Q000187:drug effects*; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D013649:Taste / Q000187:drug effects*
D013759:Dronabinol