[A case with clinical features of progressive supranuclear palsy with apraxia--corticobasal degeneration?].
We report a 65-year-old female who have suffered from progressive gait disturbance for 3 years, followed by disorientation and forgetfulness. Neurological examination revealed dementia, constructional disability, limb kinetic apraxia, supranuclear gaze palsy, especially on downward gaze, symmetrical muscle rigidity and bradykinesia. Involuntary movements were undetectable. Brain MRI showed significant brain atrophy in the left fronto-parietal lobe. The three-dimensional surface display with 131I-IMP demonstrated decreased cerebral blood flow in the left frontoparietal cortex. The diagnosis of this case is discussed with regard to either progressive supranuclear palsy or corticobasal degeneration or both.
Takeda
M
M
Fifth Department of Internal Medicine, Hyogo College of Medicine.
Okuda
B
B
Tachibana
H
H
Sugita
M
M
D000368:Aged; D001480:Basal Ganglia Diseases / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013494:Supranuclear Palsy, Progressive / Q000150:complications / Q000175:diagnosis*; D015899:Tomography, Emission-Computed, Single-Photon