title: Reliability of blood pressure, heart rate, and Doppler-derived hemodynamic measurements during exercise.
abstract: Doppler echocardiography of aortic blood flow, heart rate, and blood pressure represent noninvasive methods for evaluation of the hemodynamic effects of pharmacologic agents or other stimuli during rest and exercise. In this study the reliability of continuous-wave Doppler echocardiography for detecting the effects of various interventions on left ventricular systolic function during exercise was assessed. The reliability of Doppler measurements was compared with that found for measurements of simultaneously obtained heart rate and blood pressure. Exercise treadmill testing was performed at 0, 2, 4, 6, and 8 hours in 18 healthy male subjects. All measurements were performed at rest and during the last half of each exercise stage. Reliability of peak modal velocity, peak aortic blood flow acceleration, heart rate, and blood pressure was measured by the intraclass correlation coefficient (ICC) at each stage. ICC reliability of greater than 0.75 is considered excellent, 0.4 to 0.75 fair to good, and less than 0.4 poor. The reliability of all Doppler-derived parameters, heart rate, and blood pressure improved with increasing stage of exercise. Peak modal velocity, peak acceleration, heart rate, and manually obtained systolic blood pressure had ICCs of 0.75 or greater by stage 3. The reliability of Doppler-derived aortic blood flow parameters was good or excellent at rest and advanced stages of exercise. Continuous-wave Doppler echocardiography is a reliable method for performing studies to assess the effects of interventions on cardiovascular function during exercise.
authors.affiliation: Division of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Woodward
authors.forename: G D
authors.initials: GD
authors.lastname: Clifton
authors.forename: R A
authors.initials: RA
authors.lastname: McCoy
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
authors.forename: M R
authors.initials: MR
authors.lastname: Harrison
mesh_terms: D000328:Adult; D001011:Aorta / Q000502:physiology; D001783:Blood Flow Velocity; D001794:Blood Pressure; D015150:Echocardiography, Doppler; D005080:Exercise Test; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D015203:Reproducibility of Results