title: Cerebrospinal fluid fistula: the identification and management in pediatric temporal bone fractures.
abstract: Cerebrospinal fluid (CSF) fistula represents a potentially lethal complication and requires a high index of suspicion to make the diagnosis. A 12-year retrospective study of pediatric basilar skull fractures identified 147 patients with temporal bone fractures, of which 37 patients exhibited evidence of CSF fistula. The diagnosis is made from a combination of clinical, radiographic, and chemical evaluation. The evolution of diagnostic techniques are reviewed, and the more recent and sensitive tests, such as beta-2 transferrin, are emphasized. Treatment of CSF fistula is nonsurgical in most cases. Surgical exploration and mastoid obliteration were required in two patients, and the indications for surgical treatment are explored. The use of antibiotic prophylaxis is controversial and not routinely indicated.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh School of Medicine, PA, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: McGuirt
authors.forename: S E
authors.initials: SE
authors.lastname: Stool
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001510:Bed Rest; D002558:Cerebrospinal Fluid Otorrhea / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery / Q000628:therapy; D002559:Cerebrospinal Fluid Rhinorrhea / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D004322:Drainage; D005402:Fistula / Q000175:diagnosis / Q000209:etiology / Q000601:surgery / Q000628:therapy; D005500:Follow-Up Studies; D005947:Glucose / Q000134:cerebrospinal fluid; D034381:Hearing Loss / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D008416:Mastoid / Q000601:surgery; D008586:Meningitis, Pneumococcal / Q000209:etiology; D012189:Retrospective Studies; D012887:Skull Fractures / Q000150:complications* / Q000000981:diagnostic imaging; D013701:Temporal Bone / Q000000981:diagnostic imaging / Q000293:injuries*; D014057:Tomography, X-Ray Computed; D014168:Transferrin / Q000134:cerebrospinal fluid
chemical_list: D000900:Anti-Bacterial Agents; D014168:Transferrin; D005947:Glucose