title: Specific overexpression of P53 in sarcoma derived from Rat-1 cells transformed by cigarette smoking condensate-treated human fetal lung DNA.
abstract: The p53 protein is highly expressed in fibrosarcoma derived from Rat-1 cells transfected with cigarette smoke condensate-treated human fetal lung DNA but expressed low in the counterparts of nitroso-N-methylurea and dimethyl sulfoxide groups. Our results denoted that a high expression of p53 protein specifically contributes to the initiation of human lung carcinogenesis induced by cigarette smoke condensate. High expression and missense mutation of p53 may probably be a potential biomarker of initiation of human lung carcinogenesis.
authors.affiliation: Cancer Institute, Peking Union Medical College (PUMC), P.R. China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Li
authors.forename: H J
authors.initials: HJ
authors.lastname: Wei
authors.forename: X M
authors.initials: XM
authors.lastname: Luo
authors.forename: X Y
authors.initials: XY
authors.lastname: Liu
authors.forename: Z G
authors.initials: ZG
authors.lastname: Chen
authors.forename: J W
authors.initials: JW
authors.lastname: Dai
authors.forename: Y M
authors.initials: YM
authors.lastname: Feng
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000196:embryology; D051379:Mice; D008819:Mice, Nude; D010947:Plants, Toxic; D051381:Rats; D012091:Repetitive Sequences, Nucleic Acid; D012513:Sarcoma, Experimental / Q000235:genetics* / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects*; D014026:Nicotiana; D014162:Transfection; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D004247:DNA