Effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on myocardial dysfunction after a brief ischemia in anesthetized dogs.
The effect of a 30-min infusion of 3'-angeloyloxy-4'-acetoxy-3', 4'-dihydroseselin (Pd-Ia), a coumarin isolated from Peucedanum praeruptorum Dunn 0.15 mg.kg-1.min-1 on regional myocardial dysfunction was examined in 16 anesthetized open-chest dogs subjected to a 15-min occlusion of the left anterior descending coronary artery followed by a 3-h reperfusion. Segment lengths of left ventricular wall were measured with an ultrasonic micrometer. The control caused a decrease in the % of segment shortening (SS%) throughout the reperfusion period (n = 8), while Pd-Ia ameliorated segment function immediately after reperfusion and restored the SS% to 41 +/- 51% of the baseline value (n = 8, P < 0.05 vs control) 5 min after reperfusion without any significant changes in cardiohemodynamics. The improvement of myocardial function induced by Pd-Ia was maintained at least 3 h after reperfusion. These findings revealed that Pd-Ia had a cardioprotective action in stunned myocardium.
Chang
T H
TH
Department of Cardiovascular Disease Research, Tsukuba Research Laboratories, Eisai Co Ltd, Ibaraki, Japan.
Adachi
H
H
Okuyama
T
T
Zhang
K Y
KY
D000818:Animals; D002121:Calcium Channel Blockers / Q000302:isolation & purification / Q000627:therapeutic use*; D003374:Coumarins / Q000302:isolation & purification / Q000627:therapeutic use*; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005260:Female; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D017682:Myocardial Stunning / Q000517:prevention & control*
D002121:Calcium Channel Blockers; D003374:Coumarins; D004365:Drugs, Chinese Herbal; C089518:3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin