title: [Neuropsychic side-effects of therapeutic doses of zipeprol]].
abstract: We report the two first cases of neuropsychic side-effects with zipeprol (non opiate antitussive) given at therapeutic doses. In both cases, the patients showed confusion, whereas, hallucinations occurred only in one case. The anticholinergic activity of zipeprol might explain these effects. These two cases are in agreement with zipeprol central nervous system action.
authors.affiliation: Centre régional de pharmacovigilance, CHU de Grenoble, France.
authors.forename: V
authors.initials: V
authors.lastname: Lauby
authors.forename: B
authors.initials: B
authors.lastname: Imbert
authors.forename: H
authors.initials: H
authors.lastname: Eysseric
authors.forename: I
authors.initials: I
authors.lastname: Dufrêne
authors.forename: M
authors.initials: M
authors.lastname: Mallaret
mesh_terms: D000996:Antitussive Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D010879:Piperazines / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000209:etiology*
chemical_list: D000996:Antitussive Agents; D010879:Piperazines; C013341:zipeprol
vernacular_title: Effets neuropsychiques indésirables du zipéprol à dose thérapeutique.