[Biotransformation of (+)-methamphetamine in fertile hen's eggs].
On application of (+)-methamphetamine (1) to the albumen of embryonated hen's eggs it is possible to detect phase I as well as phase II metabolites of 1 in the allantois liquid. When application is effected on the first day of incubation, methamphetamine is less toxic than when effected on the sixth day of incubation. Besides unchanged 1 ten metabolites have been identified. Principal pathways of biotransformation are N-dealkylation as well as aromatic p-hydroxylation and--as phase II reactions--N-acetylation and other conjugation reactions. The total amount of the metabolites produced depends on time of incubation and is up to about 25% of the applied dose. Differences from, but also similarities to human metabolism have been noticed. Consequently, the experiment is likely to be suitable as an alternative method for testing biotransformation reactions.
Neugebauer
M
M
Pharmazeutisches Institut, Rheinischen Friedrich-Wilhelms-Universität, Bonn.
D000107:Acetylation; D000818:Animals; D001711:Biotransformation; D002642:Chick Embryo; D003640:Dealkylation; D006900:Hydroxylation; D007928:Lethal Dose 50; D008694:Methamphetamine / Q000493:pharmacokinetics* / Q000633:toxicity; D013237:Stereoisomerism
D008694:Methamphetamine
Biotransformation von (+)-Metamfetamin im bebrüteten Hühnerei.