title: Tau immunoreactivity associated with aluminum maltolate-induced neurofibrillary degeneration in rabbits.
abstract: Intracisternal administration of aluminum maltolate to rabbits produces a marked argyrophilic neurofibrillary degeneration (NFD) which is also immunoreactive for both phosphorylated and non-phosphorylated microtubule associated protein tau. Using tissue fixation in PBF, the monoclonal antibodies Tau-2 and AT8 stain the NFD. Dephosphorylation markedly reduces the positivity of AT8. Using PLP-fixed tissue, monoclonal antibody Tau-1 also immunostains aluminum-induced NFD.
authors.affiliation: Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.
authors.forename: J
authors.initials: J
authors.lastname: Savory
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: M M
authors.initials: MM
authors.lastname: Herman
authors.forename: M R
authors.initials: MR
authors.lastname: Reyes
authors.forename: M R
authors.initials: MR
authors.lastname: Wills
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies; D001921:Brain / Q000276:immunology; D007150:Immunohistochemistry; D008526:Medulla Oblongata / Q000276:immunology; D008636:Mesencephalon / Q000276:immunology; D009410:Nerve Degeneration; D016874:Neurofibrillary Tangles / Q000276:immunology / Q000648:ultrastructure*; D011817:Rabbits; D016875:tau Proteins / Q000276:immunology*
chemical_list: D000906:Antibodies; D016875:tau Proteins; D000535:Aluminum