title: Endocarditis due to high-level gentamicin-resistant Enterococcus faecalis.
abstract: We report a case of aortic valve endocarditis caused by Enterococcus faecalis highly resistant to gentamicin, which failed to respond to conventional antibiotic combination therapy. Extensive in vitro testing was required to determine an appropriate antimicrobial regimen. Despite bacteriological resolution and cardiac surgery the patient died from complications of infective endocarditis.
authors.affiliation: Public Health Laboratory, St George's Hospital, London, UK.
authors.forename: P Y
authors.initials: PY
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Das
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D013293:Enterococcus faecalis / Q000187:drug effects; D005839:Gentamicins; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male
chemical_list: D005839:Gentamicins; D002939:Ciprofloxacin; D000667:Ampicillin