title: A method for quantitative image assessment based on redundant feature measurements and statistical reasoning.
abstract: Advances in computer graphics and electronics have contributed significantly to the increased utilization of digital imaging throughout the scientific community. Recently, as the volume of data being gathered for biomedical applications has begun to approach the human capacity for processing, emphasis has been placed on developing an automated approach to assist health scientists in assessing images. Methods that are currently used for analysis often lack sufficient sensitivity for discriminating among elements that exhibit subtle differences in feature measurements. In addition, most approaches are highly interactive. This paper presents an automated approach to segmentation and object recognition in which the spectral and spatial content of images is statistically exploited. Using this approach to assess noisy images resulted in correct classification of more than 97% of the pixels evaluated during segmentation and in recognition of geometric shapes irrespective of variations in size, orientation, and translation. The software was subsequently used to evaluate digitized stained blood smears.
authors.affiliation: Department of Pathology, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Foran
authors.forename: R A
authors.initials: RA
authors.lastname: Berg
mesh_terms: D000465:Algorithms; D003585:Cell Biology; D003116:Color; D016002:Discriminant Analysis; D005583:Fourier Analysis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D010363:Pattern Recognition, Automated; D012680:Sensitivity and Specificity; D012986:Software Validation