Changes in the activity of NADH-oxidase in rat tissues during experimental diabetes.
The effects of alloxan diabetes and its reversal with insulin treatment, on NADH-oxidase (E.C.1.6.99.3) was measured in the microsomal fractions of brain, liver and kidney at different time interval after diabetes induction. A significant increase was found in the enzyme activity in brain and kidney microsomes of the diabetic animals, whereas liver showed a decrease. The decrease in the NAD+/NADH ratio in the diabetes reported earlier could be due to the changes in the enzyme activity as well as other changes in the metabolite concentration.
Askar
M A
MA
Hormone & Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Baquer
N Z
NZ
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology* / Q000378:metabolism; D007328:Insulin / Q000627:therapeutic use; D007668:Kidney / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; D009097:Multienzyme Complexes; D000496:Alloxan; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases