[Light and electron microscopic histochemical studies of alkaline phosphatase (ALP) isoenzymes in gastric cancer].
By using light and electron microscopic histochemical techniques, the activities and distributions of ALP isoenzymes in gastric cancers and benign gastric diseases were examined. The results showed: Nagao, Regan and Kasahara isoenzymes, which were not expressed in normal gastric mucosae and non-malignant lesions, may be considered as the tumor markers of gastric cancer. The epithelium of intestinal metaplasia exhibited intestinal-type ALP only, which was one of the markers of well-differentiated intestinal metaplasia. In the view-point of the gene expression of ALP isoenzymes, two mutation hypothesis and recessive-gene mutation hypothesis may be proper for gastric cancer.
Su
Y H
YH
Department of Pathology, Anhui Medical University, Hefei.
Yang
G L
GL
Dong
Y M
YM
D000230:Adenocarcinoma / Q000201:enzymology*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D058851:GPI-Linked Proteins; D005753:Gastric Mucosa / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D011230:Precancerous Conditions / Q000201:enzymology* / Q000235:genetics; D013274:Stomach Neoplasms / Q000201:enzymology*
D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D007527:Isoenzymes; C055791:germ-cell AP isoenzyme; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental