title: Acute myeloid leukemia and diabetes insipidus: results in 5 patients.
abstract: The clinical and hematological characteristics of 5 patients affected with both acute myeloid leukemia (AML) and diabetes insipidus (DI) are described. Banded chromosomal analysis demonstrated monosomy 7 in 2 patients and a complex cytogenetic rearrangement in another. No patient entered complete remission with standard induction chemotherapy. These data confirm that in patients with AML, the association of DI (with or without monosomy 7) is an unfavorable prognostic factor.
authors.affiliation: Institute of Hematology, University of Pavia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Castagnola
authors.forename: E
authors.initials: E
authors.lastname: Morra
authors.forename: P
authors.initials: P
authors.lastname: Bernasconi
authors.forename: C
authors.initials: C
authors.lastname: Astori
authors.forename: A
authors.initials: A
authors.lastname: Santagostino
authors.forename: C
authors.initials: C
authors.lastname: Bernasconi
mesh_terms: D000328:Adult; D002897:Chromosomes, Human, Pair 7; D003919:Diabetes Insipidus / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000235:genetics; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D011379:Prognosis