Perturbed (procoagulant) endothelium and deviations within the fibrinolytic system during the third trimester of normal pregnancy. A possible link to placental function.
OBJECTIVE
To evaluate the endothelial cell state and the possible relation to placental function in the third trimester of normal pregnancy by an indirect assessment of endothelial cell function. STUDY-DESIGN. Twenty-six pregnant women entered the study in the 30th week of pregnancy. Von Willebrand Factor, urate and key hemostatic variables were quantified at entry, and during the 33rd and 37th weeks of pregnancy.


RESULTS
Levels of von Willebrand Factor, PAI-1 antigen, t-PA antigen; variables produced by the endothelial cell, increased during the third trimester of pregnancy. Serum urate, which is correlated with clinical outcome of pregnancy, increased during the study period and correlated directly with von Willebrand Factor and PAI-1 antigen, respectively. There was an inverse correlation between the concentrations of placenta-derived PAI-2 antigen and urate.


CONCLUSIONS
In healthy human pregnancy the markers of endothelial related processes of coagulation and fibrinolysis pointed towards a procoagulatory state of the endothelial cell. However, the balance between fibrin formation and resolution seemed to be maintained in uncomplicated pregnancy. Our study indicated an association between this change of endothelial cell function and placental function.
Sørensen
J D
JD
Perinatal Epidemiological Research Unit, University of Aarhus, Denmark.
Secher
N J
NJ
Jespersen
J
J
D000328:Adult; D000941:Antigens / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D005260:Female; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011247:Pregnancy / Q000097:blood* / Q000502:physiology*; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000502:physiology; D010959:Tissue Plasminogen Activator / Q000097:blood*; D014527:Uric Acid / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis*
D000941:Antigens; D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D014841:von Willebrand Factor; D014527:Uric Acid; D010959:Tissue Plasminogen Activator