title: Signal transduction via serine/threonine kinase receptors.
abstract: A number of serine/threonine kinase receptors have recently been identified. Most of the members of this family are type I or type II receptors for proteins in the transforming growth factor-beta (TGF-beta) superfamily. The type I and type II receptors form heteromeric receptor complexes after binding of the ligands, and transduce intracellular signals. TGF-beta type I receptor needs type II receptor for ligand binding, and type II receptor needs type I receptor for signalling. The signal transducing molecules that interact with heteromeric serine/threonine kinase receptor complexes remain to be elucidated; cyclin-dependent kinases and the retinoblastoma protein appear to be downstream elements in the antiproliferative pathway of TGF-beta.
authors.affiliation: Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Miyazono
authors.forename: P
authors.initials: P
authors.lastname: ten Dijke
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: C H
authors.initials: CH
authors.lastname: Heldin
mesh_terms: D000818:Animals; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction
chemical_list: D017978:Receptors, Growth Factor; D017346:Protein Serine-Threonine Kinases