title: Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. VI. Indazole derivatives.
abstract: Synthesis and pharmacological evaluation of novel indazole derivatives are described. These compounds were found to exhibit both thromboxane A2 (TXA2) synthetase-inhibitory and bronchodilatory activities. This observation supports the idea that the partial structure of the 3-pyridyl and phenyl groups with a methylene insertion is an important component for well-balanced activities.
authors.affiliation: Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd. Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: N
authors.initials: N
authors.lastname: Maruyama
authors.forename: T
authors.initials: T
authors.lastname: Koga
authors.forename: K
authors.initials: K
authors.lastname: Kamei
authors.forename: M
authors.initials: M
authors.lastname: Akima
authors.forename: T
authors.initials: T
authors.lastname: Kuroki
authors.forename: M
authors.initials: M
authors.lastname: Hamana
authors.forename: N
authors.initials: N
authors.lastname: Ohi
mesh_terms: D000284:Administration, Oral; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D007191:Indazoles / Q000737:chemistry* / Q000494:pharmacology; D008297:Male; D008689:Methacrylates / Q000494:pharmacology; D010421:Pentanoic Acids / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors* / Q000097:blood; D014132:Trachea / Q000187:drug effects
chemical_list: D001572:Benzofurans; D001993:Bronchodilator Agents; D005229:Fatty Acids, Monounsaturated; D006633:Histamine Antagonists; D007191:Indazoles; D008689:Methacrylates; D010421:Pentanoic Acids; D011725:Pyridines; D000628:Aminophylline; D013930:Thromboxane-A Synthase; C045446:isbogrel; C039936:furegrelate; C034364:ozagrel; C060219:ridogrel