title: [The effect of space flight factors on the cellular proliferative activity of different eye tissues during lens regeneration in the Spanish newt Pleurodeles waltlii].
abstract: The proliferative activity of the cells of various eye tissues was studied during lens regeneration in Pleurodeles waltlii under the influence of space-flight factors. After space-flight termination, the index of 3H-thymidine labelled nuclei increased reliably in the lens regenerate, in the ciliary zone of the iris, and in the growth zone of the retina, i.e., in the eye tissues that are not directly involved in formation of the regenerate cell population. The rate of increase in regenerate size was higher in the flight group than in the control. Enhancement of the proliferative activity of eye tissues, acceleration of lens regeneration, and the larger size of the regenerates are related to hormonal changes arising under the effect of space-flight factors. We propose that changes in calcium metabolism under the conditions of microgravity (in particular, increased prolactin production) accelerates the regeneration of both lens and limb in P. waltlii.
authors.forename: N V
authors.initials: NV
authors.lastname: Brushlinskaia
mesh_terms: D000818:Animals; D002455:Cell Division; D005123:Eye / Q000166:cytology*; D006112:Gravitation; D007908:Lens, Crystalline / Q000502:physiology*; D010999:Pleurodeles; D012038:Regeneration; D018531:Spacecraft; D013997:Time Factors; D014586:USSR; D014732:Vibration
vernacular_title: Vliianie faktorov kosmicheskogo poleta na proliferativnuiu aktivnost' kletok razlichnykh tkaneĭ glaza pri regeneratsii khrustalika u ispanskogo tritona Pleurodeles waltlii.