Pharmacological approaches to reduce perioperative transfusion requirements in the aged.
Although iron deficiency is undoubtedly the commonest cause of anaemia even in elderly people, the aetiology is not always clear owing to various underlying diseases. Correction of anaemia is sometimes needed before surgery. The use of drugs that may influence blood coagulation, such as aspirin (acetylsalicylic acid), should be checked. Perioperative allogenic blood transfusion can often be avoided by the use of autologous blood and improved surgical techniques. Autologous blood donations are preferable in cases of planned surgery. Epoetin (recombinant human erythropoietin) in combination with iron supplementation facilitates the donation of autologous blood, even in elderly patients. Another method of avoiding allogenic blood transfusion is the collection and reuse of the blood a patient sheds in operations. During and/or after surgery, many haemostatic agents are available. Moreover, recent developments in gene engineering have enabled the utilisation of recombinant cytokines and coagulation factors. Further work remains to be done to define the proper use of these agents.
Tasaki
T
T
Blood Transfusion Service, Fukushima Medical College, Japan.
Ohto
H
H
Motoki
R
R
D000368:Aged; D000375:Aging / Q000097:blood; D018798:Anemia, Iron-Deficiency / Q000209:etiology / Q000517:prevention & control; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D004921:Erythropoietin / Q000502:physiology; D005853:Geriatrics; D006801:Humans; D007430:Intraoperative Care; D011300:Preoperative Care
D004921:Erythropoietin