Comparison of ropivacaine and bupivacaine in extradural analgesia for the relief of pain in labour.
Forty women having requested extradural analgesia for labour were allocated randomly to receive 0.5% ropivacaine or bupivacaine 10 ml as the main dose. When a top-up was requested, 0.25% ropivacaine or bupivacaine 10 ml was given (the same drug as the main dose). The study ended when a second top-up was requested or delivery of the baby occurred. Pain from two contractions was assessed before extradural block by visual analogue scoring and thereafter with every contraction. Sensory block and motor block were assessed at intervals. The only significant difference between the groups was a shorter onset of pain relief after the main dose of bupivacaine; there were no other significant differences in duration, onset of pain relief after top-up, quality of analgesia, spread of sensory block and motor block between the groups. Cardiovascular changes and neonatal outcome were similar in the two groups.
McCrae
A F
AF
Department of Anaesthetics, Royal Infirmary of Edinburgh.
Jozwiak
H
H
McClure
J H
JH
D000293:Adolescent; D000328:Adult; D000577:Amides; D015360:Analgesia, Epidural; D016362:Analgesia, Obstetrical; D000779:Anesthetics, Local; D002045:Bupivacaine; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D009046:Motor Neurons / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D011247:Pregnancy; D000077212:Ropivacaine; D013997:Time Factors
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D002045:Bupivacaine