title: The kinase insert domain receptor gene (KDR) has been relocated to chromosome 4q11-->q12.
abstract: Through in situ hybridization of a genomic DNA probe to metaphase chromosomes, we have localized the KDR gene to 4q11-->q12. This is the same locus as that for two other receptor tyrosine kinases, PDGFRA and KIT. This location for KDR differs from that which we previously reported using a cDNA probe. Using cDNA probes for both KDR and KIT identifies a locus at 4q31-->q32 which may uncover another cluster of receptor tyrosine kinase genes.
authors.affiliation: Department of Human Genetics, Roswell Park Cancer Institute, Buffalo NY.
authors.forename: S N
authors.initials: SN
authors.lastname: Sait
authors.forename: M
authors.initials: M
authors.lastname: Dougher-Vermazen
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
authors.forename: B I
authors.initials: BI
authors.lastname: Terman
mesh_terms: D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D008856:Microscopy, Fluorescence; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D017978:Receptors, Growth Factor / Q000235:genetics*; D040262:Receptors, Vascular Endothelial Growth Factor
chemical_list: D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor