title: Cerebrovascular response to carbon dioxide during sodium nitroprusside- and isoflurane-induced hypotension.
abstract: We have examined the cerebrovascular response to carbon dioxide during normotension, sodium nitroprusside (SNP)-induced hypotension and high dose isoflurane-induced hypotension in 10 patients who received a standardized general anaesthetic. Carbon dioxide reactivity was determined by varying PaCO2 between 3.0 and 8.0 kPa and recording simultaneously blood flow velocity from the middle cerebral artery (vmca). The paired vmca-PaCO2 data were analysed using linear regression to determine carbon dioxide reactivity. During hypotension, both high-dose isoflurane and SNP reduced significantly mean absolute (from 17.4 (SEM 2.3) to 13.0 (1.7) and 8.8 (1.3) cm s-1 kPa-1, respectively; P < 0.05) and relative (from 32.5 (3.8) to 23.6 (2.0) and 15.5 (1.3)% kPa-1, respectively; P < 0.05) cerebrovascular reactivity to carbon dioxide. This reduction was greater during SNP-induced hypotension (P < 0.05). We conclude that cerebrovascular reactivity to carbon dioxide was attenuated during isoflurane and SNP-induced hypotension, and that it was better preserved during isoflurane-induced hypotension.
authors.affiliation: Department of Anesthesiology, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104, USA.
authors.forename: B F
authors.initials: BF
authors.lastname: Matta
authors.forename: A M
authors.initials: AM
authors.lastname: Lam
authors.forename: T S
authors.initials: TS
authors.lastname: Mayberg
authors.forename: C C
authors.initials: CC
authors.lastname: Eng
authors.forename: S
authors.initials: S
authors.lastname: Strebel
mesh_terms: D000328:Adult; D000758:Anesthesia; D001783:Blood Flow Velocity; D002245:Carbon Dioxide / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006339:Heart Rate; D006801:Humans; D007023:Hypotension, Controlled; D007530:Isoflurane; D008875:Middle Aged; D009599:Nitroprusside; D012044:Regression Analysis; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D002245:Carbon Dioxide; D009599:Nitroprusside; D007530:Isoflurane