Diet-induced thermogenesis is lower in rats fed a lard diet than in those fed a high oleic acid safflower oil diet, a safflower oil diet or a linseed oil diet.
The objectives of the present study were to examine the effects of dietary fats differing in fatty acid composition on diet-induced thermogenesis, sympathetic activity in brown adipose tissue and body fat accumulation in rats. Rats were meal-fed for 12 wk an isoenergetic diet based on lard, high oleic acid safflower oil, safflower oil or linseed oil, and norepinephrine turnover rates in brown adipose tissue were then estimated. Whole-body oxygen consumption after the meal indicated that diet-induced thermogenesis was significantly lower in rats fed the lard diet than in those fed the other diets. The norepinephrine turnover rate in the interscapular brown adipose tissue was also significantly lower in the lard diet group than in the other diet groups. The carcass fat content was significantly higher in the lard diet group than in the other diet groups, whereas the abdominal adipose tissue weights were the same in all diet groups. These results suggest that the intake of animal fats rich in saturated fatty acids, compared with the intake of vegetable oils rich in monounsaturated or polyunsaturated fatty acids, decreases diet-induced thermogenesis by a decline of sympathetic activity in brown adipose tissue, resulting in the promotion of body fat accumulation.
Takeuchi
H
H
Research Laboratory, Nisshin Oil Mills, Yokohama, Japan.
Matsuo
T
T
Tokuyama
K
K
Shimomura
Y
Y
Suzuki
M
M
D002001:Adipose Tissue, Brown / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004041:Dietary Fats / Q000032:analysis / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000032:analysis / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000032:analysis / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000032:analysis / Q000378:metabolism; D008043:Linseed Oil / Q000032:analysis / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009829:Oleic Acids / Q000032:analysis / Q000494:pharmacology; D010101:Oxygen Consumption / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012450:Safflower Oil / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*
D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D009829:Oleic Acids; D012450:Safflower Oil; D008043:Linseed Oil; C029310:lard; D009638:Norepinephrine