Collection and use of circulating hematopoietic progenitor cells.
Although lymphocytes and monocytes are becoming increasingly important in transfusion therapy, peripheral stem cells have been responsible for the recent explosive interest in harvesting mononuclear cells from the peripheral circulation. Despite their low concentration in peripheral blood and the consequent difficulty in cell collection, circulating hematopoietic progenitor cells are collected and used almost routinely. These mononuclear cells, possessing the capacity for hematopoietic reconstitution and the potential for definitive therapy of a variety of disorders, have been the focus of recent intense interest in transfusion medicine.
Lee
J H
JH
Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Klein
H G
HG
D000328:Adult; D000818:Animals; D001771:Blood Banks; D001773:Blood Cells / Q000187:drug effects; D001793:Blood Preservation / Q000379:methods*; D016026:Bone Marrow Transplantation; D002648:Child; D003114:Colony-Forming Units Assay; D015925:Cryopreservation / Q000379:methods*; D006410:Hematopoiesis / Q000187:drug effects; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D007937:Leukapheresis / Q000379:methods*; D007938:Leukemia / Q000097:blood / Q000628:therapy; D008223:Lymphoma / Q000097:blood / Q000628:therapy; D009369:Neoplasms / Q000097:blood / Q000628:therapy; D051381:Rats
D016298:Hematopoietic Cell Growth Factors