title: Successful cryotherapic treatment and overview of multiple clear cell acanthomas.
abstract: BACKGROUND
  Clear cell acanthoma (CCA) is a usually solitary benign epidermal-tumor. Multiple lesions are infrequently reported.
  
  
  OBJECTIVE
  A case of multiple eruptive CCA is reported in which a successful cryotherapic treatment was performed.
  
  
  METHODS
  A 59-year-old man with varicose veins and dry skin presented with 17 eruptive asymptomatic papulo-nodular lesions on both legs.
  
  
  RESULTS
  Two lesions were excised with a histologically confirmed diagnosis of CCA. Other lesions were treated with liquid nitrogen. All the lesions resolved with minimal residual scarring after three to four treatments.
  
  
  CONCLUSIONS
  Multiple CCA is a rare condition; fewer than 20 cases having been described. The presence of associated conditions like dry skin and varicose veins are discussed. Because of the tendency of persistence of the lesions, cryotherapic treatment may be a useful method of therapy.
authors.affiliation: Clinica Dermatologica IV, Università degli Studi di Milano, Ospedale S. Paolo, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Betti
authors.forename: C
authors.initials: C
authors.lastname: Bruscagin
authors.forename: E
authors.initials: E
authors.lastname: Inselvini
authors.forename: M
authors.initials: M
authors.lastname: Palvarini
authors.forename: C
authors.initials: C
authors.lastname: Crosti
mesh_terms: D017679:Cryotherapy; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology*; D014648:Varicose Veins / Q000150:complications