[Effects of ginsenoside B on isolated atrium of guinea pigs].
It was found that Ginsenoside B (GSB) could reduce the myocardial systolic power and frequency of the isolated atrium of guinea pigs in a concentration-dependent way, and obviously prolong the functional refractory period of the left atrium. GSB could competitively antagonize the positive inotropic action of Iso, and non-competitively antagonize the positive inotropic action of CaCl2 on the isolated right atrium of guinea pigs.
Guo
J S
JS
Institute of Chinese Materia Medica Development, Hunan College of Traditional Chinese Medicine, Changsha.
Jin
Z Q
ZQ
Peng
Z P
ZP
Jiang
M L
ML
Wang
X J
XJ
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002122:Calcium Chloride / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D005260:Female; D036145:Ginsenosides; D006168:Guinea Pigs; D006325:Heart Atria; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects*; D012503:Saponins / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D036145:Ginsenosides; D012503:Saponins; C093162:ginsenoside B; D007545:Isoproterenol; D002122:Calcium Chloride