Transdermal absorption of dimethindene in man.
Dimethindene and its metabolite N-demethyldimethindene were determined in human urine after dermal administration of dimethindene. The HPLC-method used was previously described. Data of 8 volunteers are presented. After 32 h an average of 0.023% of the administered dose of dimethindene and 0.022% of N-demethyldimethindene were excreted into urine. Since also after oral administration of dimethindene only about 1% of unmetabolised dimethindene is found in urine it can be concluded that a certain amount of dimethindene is absorbed through the skin after dermal administration.
Radler
S
S
Institute of Pharmaceutical Chemistry, University of Münster, Germany.
Blaschke
G
G
D000279:Administration, Cutaneous; D004115:Dimethindene / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D012869:Skin Absorption
D004115:Dimethindene