Potentiometric determination of the partition and distribution coefficients of dianionic compounds.
The potentiometric determination of the partition and distribution coefficients of two dianionic hexapeptide derivatives is described. For each of these compounds, the partition coefficient of the dianion makes the largest contribution to the distribution coefficient at pH 7.4.
Clarke
F H
FH
ChemClarke, Inc., Califon, NJ 07830.
Cahoon
N M
NM
D000595:Amino Acid Sequence; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000037:antagonists & inhibitors*; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D000442:Octanols; D009842:Oligopeptides / Q000737:chemistry*; D011199:Potentiometry; D012995:Solubility
D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D000442:Octanols; D009842:Oligopeptides; C076213:PD 142893; C082887:PD 145065