[Effects of m-nisoldipine on arterial baroreflex sensitivity in anesthetized rats].
Baroreflex sensitivity (BRS) in anesthetized rats was measured as the slope of the regression line of the concomitant maximal change in heart rate (delta R-R) and blood pressure (delta BP) induced by bolus i.v. phenylephrine or sodium nitroprusside, m-nisoldipine (m-Nis) i.v. 5, 10, 20 micrograms.kg-1 depressed the BRS (2.6 +/- 0.2, 2.4 +/- 0.3, 1.6 +/- 0.2, or 1.7 +/- 0.1, 1.6 +/- 0.2, and 1.4 +/- 0.2 ms.kPa-1, respectively) compared with before medication (P < 0.01). m-Nis may act directly on carotid sinus to depress the BRS, but not through cardiac beta or M receptor nor through central nervous system.
Zhang
Y L
YL
Department of Pharmacology, Hebei Medical College, Shijiazhuang, China.
Fu
S X
SX
Li
Y S
YS
D000818:Animals; D017704:Baroreflex / Q000187:drug effects*; D002346:Carotid Sinus / Q000502:physiology; D007536:Isomerism; D008297:Male; D015737:Nisoldipine / Q000008:administration & dosage / Q000494:pharmacology*; D011311:Pressoreceptors / Q000187:drug effects; D051381:Rats
D015737:Nisoldipine