title: The significance of coumarin anticoagulation in laser assisted percutaneous transluminal angioplasty of femoropopliteal arterial obstructions.
abstract: The optimal regime of drugs to prevent thrombocyte aggregation leading to reocclusion after percutaneous transluminal angioplasty (PTA) of peripheral vessels is not established. Both antiplatelet and antithrombotic drugs are prescribed. Prospective observations of two different anticoagulation regimes were made during an ongoing multicenter study of laser-assisted PTA (PTLA) of the femoropopliteal artery. Group I (129 patients) received coumarin at least during the first month, Group II (n = 71) did not get oral anticoagulation. Seventy-eight patients (61%) in Group I and 29 patients (47%) in Group II received platelet inhibitors. Groups I and II did not differ in baseline characteristics and PTLA complications (20.9 vs. 18.2%). Ankle brachial indices at 1, 3, 6 and 12 months were similar in both groups. This observational study does not provide evidence for superiority of oral anticoagulation in the management of patients undergoing PTLA of the femoropopliteal tract.
authors.affiliation: Department of Radiology, University Hospital Utrecht, Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Tetteroo
authors.forename: W P
authors.initials: WP
authors.lastname: Mali
authors.forename: R
authors.initials: R
authors.lastname: Rienks
authors.forename: J A
authors.initials: JA
authors.lastname: van Kester
authors.forename: J D
authors.initials: JD
authors.lastname: Banga
mesh_terms: D000284:Administration, Oral; D000368:Aged; D017222:Angioplasty, Balloon, Laser-Assisted; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001157:Arterial Occlusive Diseases / Q000453:epidemiology / Q000601:surgery*; D003374:Coumarins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000601:surgery*; D011446:Prospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D003374:Coumarins; C030123:coumarin