[Synergistic action of recombinant preparations of gamma-interferon and tumor necrosis factor on the course of experimental staphylococcal infection].
The action of recombinant gamma-interferon (rINF-gamma) and tumor necrosis factor (rTNF-alpha) as well as that of their combinations was studied in a model of staphylococcal infection. It was observed that the use of rINF-gamma alone was not sufficient for the activation of the effector antibacterial function of macrophages with respect to staphylococci. At the same time it was shown that rTNF-alpha and rINF-gamma had a synergistic action on the process of the infection in mice evident from an increase in the pathogen elimination in the host. The use of the combination in the optimal doses increased the bactericidal activity of macrophages in the infected animals.
Grabchenko
N I
NI
Simonova
A A
AA
Spivak
N Ia
NIa
Parfenov
V V
VV
D000818:Animals; D015169:Colony Count, Microbial; D004357:Drug Synergism; D007371:Interferon-gamma / Q000494:pharmacology*; D008163:Luminescent Measurements; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma
Sinergidnoe deĭstvie rekombinantnykh preparatov gamma-interferona i faktora nekorza opukholi na techenie éksperimental'noĭ stafilokokkovoĭ infektsii.