[Effect of sheng mai san on lipid peroxidation in acute myocardial infarction patients].
The effect of Sheng Mai San (SMS) on the coronary heart disease (CHD) patients (30 angina pectoris and 68 acute myocardial infarction, AMI) and its peroxidation damage was studied. It was shown that the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood were decreased and the content of malondialdehyde (MDA) in plasma was increased in CHD patients in comparison with the healthy controls (P < 0.001). When SMS was orally administered in 38 AMI patients, both SOD and GSH-Px activities were increased and the level of MDA decreased (P < 0.05), and these changes were even more significant when SMS was further ingested for another two weeks (P < 0.001). At the same time, it was found that the changes of SOD, GSH-Px and MDA in the control group (30 AMI patients not taking SMS) were not significantly different (P > 0.05). It could be assumed that the pathogenesis of CHD is associated with free radical (FR) triggering a chain reaction of the lipid peroxidation, and that SMS is acting as an effective free radical scavenger, which would ameliorate the lipid peroxidation damage. Thus, SMS could be administered in the prevention and the treatment of CHD.
Lu
B J
BJ
Xinhua Hospital, Shanghai Second Medical University.
Rong
Y Z
YZ
Zhao
M H
MH
D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D016166:Free Radical Scavengers; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D013482:Superoxide Dismutase / Q000097:blood
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase