Assessment of the effect of n-butanol given to female rats in drinking water on fertility and prenatal development of their offspring.
Female rats were given aqueous solutions of n-butanol containing 0.24, 0.8 and 4% n-butanol (0.3; 1.0 and 5.0 g/kg/day) for 8 weeks before and during gestation. The control animals received tap water. The experiment was performed in two stages. The first comprised of the assessment of the oestrous cycle before exposure and then during 4-5 and 7-8 weeks of exposure, and the second stage of the fertility of female rats and their foetal development. The duration of the cycle and its individual stages in the control and the exposed females were similar. It was found that n-butanol alcohol is a foetotoxic agent and produces developmental anomalies in a foetus's skeleton and central nervous system.
Sitarek
K
K
Department of Occupational Carcinogenesis, Teratogenesis and Mutagenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
Berlińska
B
B
Barański
B
B
D020001:1-Butanol; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities / Q000187:drug effects; D000440:Butanols / Q000008:administration & dosage / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats
D000440:Butanols; D020001:1-Butanol