title: Effects of pericardial pressure on systemic and coronary hemodynamics in dogs.
abstract: The effects of pericardial tamponade on coronary capacitance and coronary systemic hemodynamics were calculated in two groups of animals subjected to increases in pericardial pressure (PCP) up to approximately 20 mmHg. In one group (A), flow in the left circumflex artery was measured in the intact animal under conditions of increased PCP. In the second group (B), coronary artery perfusion pressure was maintained constant with a pump while PCP was increased. In group A increased PCP was accompanied by a decrease in arterial pressure. This resulted in a marked decrease in coronary blood flow after vasodilation but without a change in coronary vascular resistance. In group B there was no change in coronary flow or coronary vascular resistance with increased PCP. Microsphere distribution to the left ventricular wall showed less endocardial than epicardial flow but no change in going from low to high PCP. Characteristic impedance was altered in the group B animals after vasodilation at medium and high PCP, indicating a loss of reflection sites and probably increased vessel tethering. The coronary artery in a subgroup of group B animals was also perfused by left ventricular pressure, the time constants for coronary backflow showing an 8-12% decrease in capacitance with low and high PCP; these values represent minimal epicardial capacitances vs. total bed capacitance. A diastolic model for the values for resistance and capacitance in the coronary bed is suggested. As expected, most of the capacitance is in the venous bed and most of the resistance is in the arterial bed.
authors.affiliation: Department of Physiology, School of Medicine, University of South Carolina, Columbia 29208, USA.
authors.forename: F L
authors.initials: FL
authors.lastname: Abel
authors.forename: L S
authors.initials: LS
authors.lastname: Mihailescu
authors.forename: A S
authors.initials: AS
authors.lastname: Lader
authors.forename: R G
authors.initials: RG
authors.lastname: Starr
mesh_terms: D000818:Animals; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D005260:Female; D005583:Fourier Analysis; D006439:Hemodynamics / Q000502:physiology*; D008297:Male; D010496:Pericardium / Q000502:physiology*; D011312:Pressure; D013997:Time Factors; D014655:Vascular Resistance; D014664:Vasodilation