title: Chloride channels: a state of flux.
abstract: Chloride channels play important functions in different aspects of cell physiology including volume regulation, transepithelial ion transport and stabilization of membrane potential. In recent years the molecular identity of the chloride channels defective in cystic fibrosis and myotonia congenita has been elucidated, highlighting the importance of anion-selective channels in cell and tissue function. Concurrently, several proteins have been identified as chloride channels along with proteins that possess channel regulatory behavior. Novel interactions with more potent pharmacological compounds have been reported with different chloride channels. This burgeoning field of interest is reviewed.
authors.affiliation: Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, University of Oxford, United Kingdom.
authors.forename: M A
authors.initials: MA
authors.lastname: Valverde
authors.forename: S P
authors.initials: SP
authors.lastname: Hardy
authors.forename: F V
authors.initials: FV
authors.lastname: Sepúlveda
mesh_terms: D000818:Animals; D018118:Chloride Channels / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology*
chemical_list: D018118:Chloride Channels