title: Effect of age on dopaminergic responses to protein feeding.
abstract: Renal excretory responses to protein feeding were compared in nine young (20-26 yr) and nine elderly (70-89 yr) men. Although protein increased excretion of dopamine and serotonin (5-HT, P < 0.001 for both), the basal excretion of dopamine and 5-HT was less in old than young men (P < 0.05). Protein increased sodium and water excretion in the young; responses in elderly for both were less (P < 0.025). Carbidopa markedly suppressed dopamine and 5-HT excretion in both young and old men. Carbidopa also attenuated protein-induced natriuresis and diuresis and raised serum aldosterone levels in the young but not in the old men. These age-related differences in dopamine and 5-HT excretion were not abolished by alterations in dietary NaCl. Thus, although dopamine excretion is decreased overall in elderly men, sodium and water excretion and aldosterone secretion in the old men were unaffected by alterations in dopamine production. These data suggest that impaired protein-induced natriuresis in the old men may be due to limitations in renovascular responses and that, in young men, dopamine and 5-HT may contribute to the protein-induced changes in renovascular function.
authors.affiliation: Charles A. Dana Research Institute, Department of Medicine, Beth Israel Hospital, Boston 02215, USA.
authors.forename: N K
authors.initials: NK
authors.lastname: Fukagawa
authors.forename: L G
authors.initials: LG
authors.lastname: Bandini
authors.forename: M A
authors.initials: MA
authors.lastname: Lee
authors.forename: J B
authors.initials: JB
authors.lastname: Young
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000588:Amines / Q000097:blood / Q000652:urine; D000596:Amino Acids / Q000097:blood; D001794:Blood Pressure; D001835:Body Weight; D002230:Carbidopa / Q000494:pharmacology; D003404:Creatinine / Q000652:urine; D004039:Diet, Sodium-Restricted; D004044:Dietary Proteins / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000502:physiology*; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011674:Pulse; D010130:p-Aminohippuric Acid / Q000378:metabolism
chemical_list: D000588:Amines; D000596:Amino Acids; D004044:Dietary Proteins; D006728:Hormones; D003404:Creatinine; D002230:Carbidopa; D004298:Dopamine; D010130:p-Aminohippuric Acid