In vitro and in vivo genotoxicity of hormonal drugs. VI. Fluoxymesterone.
Genotoxic evaluation of a commonly used synthetic steroidal androgen, fluoxymesterone, was undertaken using a combination of in vitro and in vivo assays. The clastogenic potential of fluoxymesterone was evident from the chromosome aberrations and sister chromatid exchanges induced by it in the cultured human lymphocytes and also from the increased frequencies of micronuclei and sister chromatid exchanges in bone marrow cells of mice. However, in Ames Salmonella assay both with and without S9 mix and in host-mediated assay using bacterial strains of S. typhimurium as indicator organism, fluoxymesterone did not cause any significant increase/decrease in His+ revertants.
Dhillon
V S
VS
Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.
Singh
J
J
Singh
H
H
Kler
R S
RS
D000818:Animals; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005474:Fluoxymesterone / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D051379:Mice; D048629:Micronuclei, Chromosome-Defective; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012485:Salmonella typhi / Q000235:genetics; D012854:Sister Chromatid Exchange
D009153:Mutagens; D005474:Fluoxymesterone