[Role of hyperbaric oxygenation in the mechanism of ammonium detoxication in resection of the liver in the presence of chronic hepatitis].
Hyperbaric oxygenation (HBO) used in 170 white rats with chronic CCL4-hepatitis after resection of the liver was conducive to repair of the reversible (glutamine synthesis) and irreversible (urea synthesis) routes of ammonium binding in hepatocytes which are disordered in chronic hepatitis. Hyperbaric oxygen regulates the effect of resection of the liver on the glutamine- and urea-synthesizing function of the hepatocytes in chronic hepatitis. Therapeutic effect of HBO persists for 4 days of the posthypoxic period under conditions of posthyperoxic hypoxia.
Savilov
P N
PN
Leonov
A N
AN
Iakovlev
V N
VN
D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000628:therapy*; D002908:Chronic Disease; D005260:Female; D005973:Glutamine / Q000096:biosynthesis; D006931:Hyperbaric Oxygenation; D008099:Liver / Q000378:metabolism / Q000601:surgery*; D000644:Quaternary Ammonium Compounds / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014508:Urea / Q000378:metabolism
D000644:Quaternary Ammonium Compounds; D005973:Glutamine; D014508:Urea
Rol' giperbaricheskoĭ oksigenatsii v mekhanizme detoksikatsii ammiaka pri rezektsii pecheni na fone khronicheskogo gepatita.