Benzpyrene treatment in adulthood increases the testosterone level in neonatally steroid(allylestrenol)-treated male rats.
1. Serum testosterone level was significantly elevated in adult male rats after a single perinatal allylestrenol administration. 2. Benzpyrene treatment of adult rats perinatally treated with allylestrenol, did not cause changes 1 week after benzpyrene treatment, but 3 weeks later an extremely high serum testosterone level was found. 3. In control animals benzpyrene administration in adulthood did not influence the serum testosterone level either 1 or 3 weeks following the treatment.
Pap
E
E
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Csaba
G
G
D000500:Allylestrenol / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001580:Benzopyrenes / Q000494:pharmacology*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D001580:Benzopyrenes; D013739:Testosterone; D000500:Allylestrenol