Molecular regulation and augmentation of prostacyclin biosynthesis.
Prostacyclin is a major vasoprotective molecule. It has multiple physiological functions. Its synthesis is determined by several enzymes of which cyclooxygenase (COX) plays a key role. Two isoforms of COX have been identified. Their expression and regulation are controlled by different mechanisms. COX-1 is constitutively expressed and physiologically important. PGI2 synthesis can be augmented by virus-mediated transfer COX-1 gene. This strategy may be useful for therapy of vascular thrombosis and tissue ischemia.
Wu
K K
KK
Vascular Biology Research Center, University of Texas Health Science Center at Houston.
D000818:Animals; D004730:Endothelium, Vascular / Q000201:enzymology*; D011464:Epoprostenol / Q000096:biosynthesis*; D018014:Gene Transfer Techniques; D006801:Humans; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*
D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases