title: Selective increase in expression of isoform PP1 gamma 1 of type-1 protein phosphatase in chondrosarcoma cells.
abstract: The expression of the two catalytic subunits of protein phosphatase (PP) type 1 PP1 gamma 1 and PP1 delta was examined in 4 cases of osteochondroma and 4 cases of enchondroma as a benign cartilaginous tumor, and 4 cases of chondrosarcoma as a malignant cartilaginous tumor using immunohistochemical analysis. The percentage of tumor cells stained positively with antiserum against PP1 catalytic subunit isoform PP1 gamma 1 were significantly higher in chondrosarcoma than in osteochondroma and enchondroma. Furthermore, chondrosarcoma showed markedly high S-phase fraction in the cell cycle of tumor cells, as compared to osteochondroma and enchondroma. These results suggest that PP1 gamma 1 is involved in the accelerated growth of malignant cells in chondrosarcoma.
authors.affiliation: Department of Pathology, Kagawa Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sogawa
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Funamoto
authors.forename: K
authors.initials: K
authors.lastname: Kohno
authors.forename: H
authors.initials: H
authors.lastname: Nishikawa
authors.forename: F
authors.initials: F
authors.lastname: Kishida
authors.forename: F
authors.initials: F
authors.lastname: Hamazaki
authors.forename: N
authors.initials: N
authors.lastname: Yamashita
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000201:enzymology* / Q000473:pathology; D002453:Cell Cycle; D002455:Cell Division; D002812:Chondroma / Q000201:enzymology* / Q000473:pathology; D002813:Chondrosarcoma / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D015831:Osteochondroma / Q000201:enzymology* / Q000473:pathology; D010749:Phosphoprotein Phosphatases / Q000096:biosynthesis*
chemical_list: D007527:Isoenzymes; D010749:Phosphoprotein Phosphatases