Recombinant cytokines for controlling mycobacterial infections.
Knowing how mycobacteria exploit host cytokines to survive and which cytokines have important roles in host defense against mycobacteria should allow the use of these molecules in the treatment of mycobacterial infections. Both interleukin 2 and interferon gamma have been used to treat patients with leprosy, and granulocyte-macrophage colony-stimulating factor is presently being administered to AIDS patients infected with Mycobacterium avium.
Bermudez
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LE
Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco 94115-1896, USA.
Kaplan
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D016207:Cytokines / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007918:Leprosy / Q000517:prevention & control; D009164:Mycobacterium Infections / Q000517:prevention & control*; D015270:Mycobacterium avium-intracellulare Infection / Q000517:prevention & control; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D014376:Tuberculosis / Q000517:prevention & control
D016207:Cytokines; D011994:Recombinant Proteins