title: [Effects of Onpi-to (TJ-8117) on mesangial injury induced by anti Thy-1 antibody].
abstract: We investigated the effect of Onpi-to (TJ-8117) on the mesangial injury induced by anti-Thy-1 antibody. TJ-8117 (400 mg/kg/day, p.o.) given from the 1st day (from the day of injection of the anti-thymocyte serum) or 4th day (after mesangial proliferation), markedly inhibited the mesangial proliferation and hypercellularity in glomeruli. TJ-8117 prevented the increase in the number of PCNA or ED-1 positive cells in glomeruli. These results suggest that TJ-8117 is effective against glomerular disease with mesangial injury.
authors.affiliation: Tsumura Central Laboratories, Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: S
authors.initials: S
authors.lastname: Shindo
authors.forename: T
authors.initials: T
authors.lastname: Hisada
authors.forename: N
authors.initials: N
authors.lastname: Fujitsuka
authors.forename: T
authors.initials: T
authors.lastname: Hibino
authors.forename: Y
authors.initials: Y
authors.lastname: Terazono
authors.forename: M
authors.initials: M
authors.lastname: Maruno
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018800:Thy-1 Antigens
chemical_list: D004365:Drugs, Chinese Herbal; D018800:Thy-1 Antigens; C093447:onpi-to