title: Frontal brain volume and context effects in short-term recall in schizophrenia.
abstract: In a group of schizophrenic patients, magnetic resonance imaging (MRI) measures of relative frontal brain volume (total frontal volume/total cerebral volume) correlated highly with the capacity to use context as an aid to recall in a verbal memory task. The dorsolateral area of the prefrontal cortex appears to have contributed most to this effect. Recall of simple word lists without contextual features revealed no correlation with relative frontal volume. With increasing contextual organization of the material, correlations between frontal volume and recall scores increased significantly. These findings are consistent with the general proposition that impairment in the use of informational redundancy is a significant component of schizophrenic pathology.
authors.affiliation: Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Maher
authors.forename: T C
authors.initials: TC
authors.lastname: Manschreck
authors.forename: B T
authors.initials: BT
authors.lastname: Woods
authors.forename: D A
authors.initials: DA
authors.lastname: Yurgelun-Todd
authors.forename: M T
authors.initials: MT
authors.lastname: Tsuang
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D002508:Cephalometry; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010153:Paired-Associate Learning; D012565:Schizophrenic Psychology; D014706:Verbal Learning / Q000502:physiology*