Effects of electroconvulsive shock on catecholamine release in the corpus striatum of the rat: a voltammetric study.
A voltammetric technique was used (differential pulse voltammetry with a carbon fibre microelectrode) to investigate dynamics of the changes of catecholamine overflow in the corpus striatum following electroconvulsive stimulation (ECS) of chloral hydrate-anaesthetized rats. Application of "maximal" ECS (50 Hz, AC, sine wave, approximately 150 mA, 0.2 s) caused large enhancement of catechol-oxidative current (CA.OC): In the first minute after its arrest, the CA.OC peak raised to 1032 +/- 405% (n = 5, mean +/- S.D.) of the controls (P < or = 0.001, Student's t-test). This large elevation of the extracellular catecholamine content ceased rapidly--the baseline level was attained in the second minute. CA.OC changes evoked by a "minimal" ECS (50 Hz, AC, sine wave, approximately 30 mA, 0.2 s) were equivocal in the first minute (increase, decrease: 145 +/- 56%, P > 0.05, n = 6). Possible mechanisms of the ECS therapeutic effect are discussed.
Pavlásek
J
J
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava.
Murgas
K
K
Masánová
C
C
Haburcák
M
M
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology; D004565:Electroconvulsive Therapy; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002395:Catecholamines