title: Preventing non-insulin-dependent diabetes.
abstract: Many risk factors for non-insulin-dependent diabetes mellitus (NIDDM), such as obesity, physical inactivity, and high-fat diet, can potentially be modified. Furthermore, some of the metabolic abnormalities, such as insulin resistance and impaired glucose tolerance, that predict diabetes can be improved by behavior modification and drug treatment. Thus, at least to some extent, NIDDM may be preventable. Several small clinical trials have addressed the hypothesis that NIDDM can be prevented by dietary modification, physical activity, or drug treatment. Some studies suggest a preventive effect, but the conclusions are limited by considerations of sample size, randomization, or intensity of the interventions. Consequently, the hypothesis that NIDDM is preventable requires further testing.
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Knowler
authors.forename: K M
authors.initials: KM
authors.lastname: Narayan
authors.forename: R L
authors.initials: RL
authors.lastname: Hanson
authors.forename: R G
authors.initials: RG
authors.lastname: Nelson
authors.forename: P H
authors.initials: PH
authors.lastname: Bennett
authors.forename: J
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: B
authors.initials: B
authors.lastname: Scherstén
authors.forename: D J
authors.initials: DJ
authors.lastname: Pettitt
mesh_terms: D001521:Behavior Therapy; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control*; D004032:Diet; D015444:Exercise; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D009765:Obesity / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D014481:United States
chemical_list: D007004:Hypoglycemic Agents