title: Scintigraphic study of propylthiouracil induced submassive hepatic necrosis.
abstract: Drug induced hepatitis is a rare complication of thiourea antithyroid drugs. In some patients, the hepatotoxicity may be severe and lead to submassive hepatic necrosis (SHN). Submassive hepatic necrosis is a potentially fatal complication which is usually recognized on the liver biopsy and histological examination or autopsy. In the case presented here, SHN was identified on Tc-99m SC liver images. Sharply defined intrahepatic photopenic abnormalities without significant colloid shift were noted. SPECT images were most remarkable and exhibited extensive liver necrosis. Resolution of hepatic abnormalities correlated with clinical and biochemical resolution of SHN. In patients with propylthiouracil hepatotoxicity, serial liver SPECT images with Tc-99m SC appear helpful for the diagnosis and follow up of SHN and, in an appropriate clinical context, may obviate the need for liver biopsy.
authors.affiliation: Department of Radiology, University of Missouri Hospital and Clinics, Columbia, USA.
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: Thakur
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000473:pathology; D009336:Necrosis; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D013671:Technetium Tc 99m Sulfur Colloid; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013671:Technetium Tc 99m Sulfur Colloid; D011441:Propylthiouracil