[Effect of nitrates on the dynamics of methemoglobin formation in rats of various ages].
Wistar male rats with body mass of 50-83 g and 327-365 g were treated per os with solution of sodium nitrate in single dose of 500 or 1000 mg/kg of body mass (on the base of nitrate-ion). The level of methemoglobin (MH) and activity of methemoglobinreductase (MHR) in blood were analyzed. It was shown that level of MH in blood of young immature rats was increased with appearance of two peaks after ingestion both doses of nitrate. The appearance of two peaks of MH in mature rats was observed only after the high dose of nitrate. Low dose of nitrate caused increase of MH concentration only one time. Both doses of nitrate did not effect on MHR activity in rat blood.
Vlaskina
S G
SG
Mamaeva
E M
EM
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D015992:Body Mass Index; D042966:Cytochrome-B(5) Reductase / Q000097:blood / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D009566:Nitrates / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
D009566:Nitrates; D042966:Cytochrome-B(5) Reductase
Vliianie nitratov na dinamiku metgemoglobinoobrazovaniia u krys razlichnykh vozrastnykh grupp.