Interactions of angiotensin II with central catecholamines.
There is a large body of anatomical and functional evidence supporting an interaction between brain angiotensin and central catecholamine systems. Angiotensin II AT1 receptors have been identified on dopamine containing cells in the substantia nigra and striatum of human brain using receptor autoradiography. Using in vivo microdialysis we have demonstrated that locally administered angiotensin II stimulates dopamine release from the striatum of conscious rats. Since some angiotensin receptor antagonists and angiotensin converting enzyme inhibitors can cross the blood brain barrier it is possible that they interact with the brain catecholaminergic systems.
Jenkins
T A
TA
Department of Medicine, University of Melbourne, Austin Hospital Heidelberg, Victoria.
Allen
A M
AM
Chai
S Y
SY
Mendelsohn
F A
FA
D000804:Angiotensin II / Q000502:physiology*; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002395:Catecholamines / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D019808:Losartan; D051381:Rats; D013777:Tetrazoles / Q000494:pharmacology
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001713:Biphenyl Compounds; D002395:Catecholamines; D007093:Imidazoles; D013777:Tetrazoles; D000804:Angiotensin II; D019808:Losartan; D004298:Dopamine