Fluoxetine treatment for dually diagnosed methadone maintained opioid addicts: a pilot study.
Twenty-two methadone maintained opioid addicts with either depression or persistent cocaine use received open label fluoxetine in addition to their methadone. Fluoxetine significantly decreased depressive symptoms from pre-treatment to endpoint in subjects with depression, while its effect on substance use was inconclusive.
Petrakis
I
I
Department of Psychiatry, Yale University, New Haven, CT, USA.
Carroll
K
K
Gordon
L
L
Cushing
G
G
Rounsaville
B
B
D000328:Adult; D003042:Cocaine; D003131:Combined Modality Therapy; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D017831:Diagnosis, Dual (Psychiatry); D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D010349:Patient Compliance / Q000523:psychology; D010555:Personality Inventory; D011613:Psychotherapy; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation
D005473:Fluoxetine; D003042:Cocaine; D008691:Methadone