Reproducible elevation of liver transaminases by topical 8-methoxypsoralen.
We present a case of a 17-year-old woman with vitiligo who had no known previous liver diseases nor any exposure to concurrent hepatotoxic drugs and who developed a liver injury while on topical methoxypsoralen photochemotherapy (PUVA). The reaction, manifested by elevated liver enzymes, was provoked on 3 consecutive occasions, and on the last one, with 1% methoxypsoralen lotion only. Although the exact mechanism of liver injury in our patient is unknown, it seems to be an idiosyncratic hypersensitivity reaction to topically applied methoxypsoralen.
Park
Y M
YM
Department of Dermatology, Uijongbu St. Mary's Hospital, Catholic University Medical College, Uijongbu City, Republic of Korea.
Kim
T Y
TY
Kim
H O
HO
Kim
C W
CW
D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000469:Alkaline Phosphatase / Q000097:blood / Q000187:drug effects; D001219:Aspartate Aminotransferases / Q000097:blood / Q000187:drug effects; D001663:Bilirubin / Q000097:blood; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008730:Methoxsalen / Q000008:administration & dosage / Q000009:adverse effects*; D009824:Ointments; D011701:PUVA Therapy / Q000009:adverse effects; D000637:Transaminases / Q000097:blood / Q000187:drug effects*; D014820:Vitiligo / Q000188:drug therapy
D009824:Ointments; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D008730:Methoxsalen