title: Study of trace elements in blood of cancer patients by proton-induced X-ray emission (PIXE) analysis.
abstract: Proton-induced X-ray emission (PIXE) analysis was employed to determine the concentrations of six elements in the plasma and erythrocytes of 18 cancer subjects (15 males and 3 females) with neoplastic disorders and in 70 controls (35 males and 35 females). It was found that the concentrations of Br, K, and Zn were significantly elevated in the erythrocytes of the cancer subjects compared to the controls, whereas the concentration of Fe was significantly depressed, but with no difference observed in the concentration of Ca. In the plasma, the concentrations of Br, Cu, Ca, and K were significantly elevated, whereas the concentrations of Fe and Zn were found to be significantly depressed compared to the controls.
authors.affiliation: Department of Haematology, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: M A
authors.initials: MA
authors.lastname: Durosinmi
authors.forename: J O
authors.initials: JO
authors.lastname: Ojo
authors.forename: A F
authors.initials: AF
authors.lastname: Oluwole
authors.forename: O A
authors.initials: OA
authors.lastname: Akanle
authors.forename: N M
authors.initials: NM
authors.lastname: Spyrou
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D009549:Nigeria; D010949:Plasma / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D014131:Trace Elements / Q000097:blood*
chemical_list: D014131:Trace Elements