The utility of chelating agents as antidotes for nephrotoxicity of gold sodium thiomalate in adjuvant-arthritic rats.
The effects of 2,3-dimercaptopropane sulphonate (DMPS) and N-(2-mercapto-2-methylpropanoyl)-L-cysteine (bucillamine) against the renal damage induced by gold sodium thiomalate (AuTM) in adjuvant-arthritic rats were studied. Arthritic rats induced by adjuvant using Mycobacterium butyricum were injected intraperitoneally with a chelating agent (0.6 mmol/kg) immediately after intramuscular injection of AuTM (0.066 mmol/kg) every other day for 21 days. Treatment with DMPS and bucillamine prevented increases in the urinary excretion of protein, aspartate aminotransferase, and glucose and blood urea nitrogen level after AuTM injection. AuTM prevented the increase in both adjuvant-injected and uninjected hind-feet volumes. The prevention of these inflamed lesions by AuTM was not affected by DMPS and bucillamine. These chelating agents decreased the gold concentration in the kidney and liver after AuTM administration, but did not affect the hepatic and renal concentrations of copper, zinc, iron, and calcium except the renal copper level after AuTM. These findings suggest that DMPS and bucillamine are very useful antidotes for gold toxicity.
Takahashi
Y
Y
NTT Kyushu General Hospital, Kumamoto, Japan.
Funakoshi
T
T
Shimada
H
H
Kojima
S
S
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D002614:Chelating Agents / Q000627:therapeutic use*; D003545:Cysteine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006052:Gold Sodium Thiomalate / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014494:Unithiol / Q000627:therapeutic use
D000931:Antidotes; D002614:Chelating Agents; D006052:Gold Sodium Thiomalate; D014494:Unithiol; D003545:Cysteine; C026535:bucillamine