title: Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme.
abstract: The purpose of this study was to compare the efficacy of stereotactic radiosurgery (SRS) and brachytherapy in the treatment of recurrent glioblastoma multiforme (GBM). The patients had either progressive GBM or pathologically proven GBM at recurrence after previous treatment for a lower grade astrocytoma. Thirty-two patients were treated with interstitial brachytherapy, and 86 received treatment with stereotactic radiosurgery (SRS). The patient characteristics were similar in the two groups. Those patients treated with SRS had a median tumor volume of 10.1 cm3 and received a median peripheral tumor dose of 13 Gy. Patients treated with brachytherapy had a median tumor volume of 29 cm3. Median dose to the periphery of the tumor volume was 50 Gy delivered at a median dose rate of 43 cGy/hour. Twenty-one patients (24%) treated with SRS were alive, with a median follow-up of 17.5 months. Median actuarial survival, measured from the time of treatment for recurrence, for all patients treated with SRS was 10.2 months, with survivals of 12 and 24 months being 45 and 19%, respectively. A younger age and a smaller tumor volume were predictive of better outcome. The tumor dose, the interval from initial diagnosis, and the need for reoperation were not predictive of outcome after SRS. Five patients (16%) treated with brachytherapy were alive, with a median follow-up of 43.3 months. The median actuarial survival for all patients treated with brachytherapy was 11.5 months. Survivals of 12 and 24 months were 44 and 17%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Brain Tumor Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Shrieve
authors.forename: E
authors.initials: E
authors.lastname: Alexander
authors.forename: P Y
authors.initials: PY
authors.lastname: Wen
authors.forename: H A
authors.initials: HA
authors.lastname: Fine
authors.forename: H M
authors.initials: HM
authors.lastname: Kooy
authors.forename: P M
authors.initials: PM
authors.lastname: Black
authors.forename: J S
authors.initials: JS
authors.lastname: Loeffler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000401:mortality / Q000628:therapy*; D002648:Child; D005260:Female; D005909:Glioblastoma / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications; D011832:Radiation Injuries; D016634:Radiosurgery; D012086:Reoperation; D013238:Stereotaxic Techniques; D016019:Survival Analysis; D017211:Treatment Failure