title: Hypertrophic discoid lupus erythematosus resembling squamous cell carcinoma.
abstract: BACKGROUND
  Hypertrophic discoid lupus erythematosus (HDLE) may resemble cutaneous squamous cell carcinoma (SCC) histologically.
  
  
  OBJECTIVE
  The histologic features that help to differentiate HDLE from SCC are reviewed.
  
  
  METHODS
  Two patients are described with HDLE.
  
  
  RESULTS
  Both patients were treated initially with Mohs surgery for "biopsy-proven" SCC. Subsequent biopsies confirmed the diagnosis of HDLE and the patients responded well to appropriate therapy. No significant complications occurred in either patient.
  
  
  CONCLUSIONS
  Lesions of HDLE may imitate SCC. Strategies are suggested to avoid surgical procedures based on an incorrect biopsy report.
authors.affiliation: Department of Dermatology, Mayo Clinic Jacksonville, FL 32224, USA.
authors.forename: C
authors.initials: C
authors.lastname: Perniciaro
authors.forename: H W
authors.initials: HW
authors.lastname: Randle
authors.forename: H O
authors.initials: HO
authors.lastname: Perry
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008179:Lupus Erythematosus, Discoid / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*