title: Antineutrophil cytoplasmic antibody-positive sera inhibit candidacidal activity of granulocytes.
abstract: Antineutrophil cytoplasmic antibodies (ANCA) are suspected of being involved in the pathogenesis of tissue injury in systemic vasculitis. We have investigated the effect of 10 sera from 8 patients with ANCA-associated diseases on the capacity of neutrophils derived from healthy persons to kill ingested Candida albicans. ANCA-containing sera inhibited candidacidal activity by 55-80% in comparison to control sera. This phenomenon could lead to the depression of antimicrobial resistance of patients with ANCA and could be involved in the pathogenesis of granuloma formation.
authors.affiliation: Department of Clinical Immunology, Charles University, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Bartůnková
authors.forename: T
authors.initials: T
authors.lastname: Fucíková
authors.forename: V
authors.initials: V
authors.lastname: Tesar
authors.forename: I
authors.initials: I
authors.lastname: Janatková
authors.forename: I
authors.initials: I
authors.lastname: Rychlík
authors.forename: S
authors.initials: S
authors.lastname: Sulková
mesh_terms: D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000276:immunology*; D002176:Candida albicans; D002177:Candidiasis / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D002478:Cells, Cultured; D014890:Granulomatosis with Polyangiitis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies