[Attempt to use the genetically engineered growth hormone SAIZEN in children with somatotropic insufficiency: results of clinical trials in Russia].
The efficacy and safety of SAISEN, a recombinant human growth hormone obtained from mammalian cells, was tested in children with hypophyseal nanism. The treatment duration was 1 year. The results indicate that SAISEN (ARES-SERONO) is a highly effective and safe preparation of growth hormone, noticeably stimulating the growth rate both in previously untreated children with somatotropic insufficiency, and in those previously treated with STH preparations. Therapy with SAISEN was not associated with any side effects, as shown by both clinical and laboratory data.
Dedov
I I
II
Peterkova
V A
VA
Goncharov
N P
NP
Buraia
T I
TI
Fofanova
O V
OV
Pankova
S S
SS
Bukhman
A I
AI
D002648:Child; D004392:Dwarfism / Q000097:blood / Q000188:drug therapy; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects / Q000172:deficiency* / Q000627:therapeutic use*; D019382:Human Growth Hormone; D006801:Humans; D008297:Male; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012426:Russia
D011994:Recombinant Proteins; D019382:Human Growth Hormone; D013006:Growth Hormone
Opyt ispol'zovaniia genno-inzhenernogo gormona rosta SAIZEN dlia lecheniia deteĭ s somatotropnoĭ nedostatochnost'iu: rezul'taty klinicheskoĭ aprobatsii v Rossii.