c-fos expression in central cardiovascular pathways.
Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.
Minson
J B
JB
Department of Medicine, Flinders University of South Australia, Adelaide.
Suzuki
S
S
Llewellyn-Smith
I J
IJ
Pilowsky
P M
PM
Arnolda
L F
LF
Chalmers
J P
JP
D000818:Animals; D001483:Base Sequence; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects / Q000294:innervation*; D015870:Gene Expression; D016762:Genes, fos / Q000187:drug effects / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D008969:Molecular Sequence Data; D009118:Muscimol / Q000494:pharmacology; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000494:pharmacology; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000235:genetics; D051381:Rats; D011921:Rats, Inbred WKY
D016376:Oligonucleotides, Antisense; D012333:RNA, Messenger; D009118:Muscimol