Cloning and sequence analysis of human thyroid transcription factor 1.
The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype. The authors isolated and analysed the human TTF-1 gene, which shows a striking homology with the rat TTF-1 gene.
Saiardi
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A
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Laboratory of Cellular and Molecular Endocrinology, Santa Maria Imbaro, Italy.
Tassi
V
V
De Filippis
V
V
Civitareale
D
D
D001483:Base Sequence; D002454:Cell Differentiation / Q000235:genetics; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D007453:Iodide Peroxidase / Q000235:genetics; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000235:genetics*; D011989:Receptors, Thyrotropin / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013954:Thyroglobulin / Q000235:genetics; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*
C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D011989:Receptors, Thyrotropin; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D013954:Thyroglobulin; D007453:Iodide Peroxidase