Systemic mastocytosis associated with chronic myelomonocytic leukemia: clinical features and response to interferon alfa therapy.
Systemic mastocytosis is a rare disease that shows marked heterogeneity in clinical manifestations and prognosis. It may be associated with hematologic disorders. We describe a patient with systemic mastocytosis associated with chronic myelomonocytic leukemia accompanied by ascites, pleural effusion, and development of skin lesions along a surgical scar. The disease responded well to interferon alfa therapy. This is the second report of successful treatment of mastocytosis with interferon alfa and the first associated with a hematologic malignancy.
Petit
A
A
Department of Dermatology, Centre Hospitalier Victor Dupouy, Argenteuil, France.
Pulik
M
M
Gaulier
A
A
Lionnet
F
F
Mahe
A
A
Sigal
M
M
D001201:Ascites / Q000150:complications; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000150:complications; D016898:Interferon-alpha / Q000627:therapeutic use*; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications*; D008415:Mastocytosis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000150:complications
D016898:Interferon-alpha