Electrical stimulation of the Gasserian ganglion induces structural alterations of calcitonin gene-related peptide-immunoreactive perivascular sensory nerve terminals in the rat cerebral dura mater: a possible model of migraine headache.
Calcitonin gene-related peptide (CGRP)-positive sensory nerve fibers in the rat supratentorial dura mater are equipped with varicosities and club-like nerve terminals, often attached to the walls of blood vessels. Brief electrical stimulation of the Gasserian ganglion results in significant swelling and increased immunohistochemical staining of ipsilateral perivascular club-like terminals, while long-lasting electrical stimulation induces their disintegration or bursting, resulting in irregular, corroded outlines of terminals and en passant beads. Stimulation-induced morphological alterations of perivascular terminals may represent a structural basis of increased CGRP content in jugular blood which follows electrical stimulation of the Gasserian ganglion and accompanies migraine attacks.
Knyihar-Csillik
E
E
Department of Clinical Neurology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
Tajti
J
J
Mohtasham
S
S
Sari
G
G
Vecsei
L
L
D000818:Animals; D001808:Blood Vessels / Q000294:innervation; D001921:Brain; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D004388:Dura Mater / Q000502:physiology* / Q000648:ultrastructure; D004558:Electric Stimulation; D005260:Female; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D009411:Nerve Endings / Q000502:physiology / Q000648:ultrastructure; D009475:Neurons, Afferent / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D012668:Trigeminal Ganglion / Q000502:physiology*
D015740:Calcitonin Gene-Related Peptide