title: [Interleukin-1 in combined detoxification therapy of surgical sepsis].
abstract: Clinical trials of Russian yeast recombinant human interleukin-2 (yrIL-2) were carried out in 17 patients with posttraumatic and postoperative sepsis to whom 33 intravenous drip infusions of the drug were administered as a single infusion or courses of 2 to 4 injections in a dose of 1,000,000 U per .1 m2 body surface. A positive clinical effect of yrIL-2 in this dose was observed on the next day after the first injection of the drug: the signs of intoxication were reliably reduced. The immunostimulating effect of yrIL-2 consisted in activation of pharmacytizing leukocytes of blood. Addition of yrIL-2 to therapeutic complex for patients with sepsis helped reliably reduce the mortality of such patients with sepsis helped reliably reduce the mortality of such patients to 29.4% vs. 63.3% in controls.
authors.forename: M V
authors.initials: MV
authors.lastname: Grinev
authors.forename: M I
authors.initials: MI
authors.lastname: Gromov
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Tsibin
authors.forename: M N
authors.initials: MN
authors.lastname: Tarelkina
authors.forename: D M
authors.initials: DM
authors.lastname: Shirokov
authors.forename: L P
authors.initials: LP
authors.lastname: Pivovarova
authors.forename: N K
authors.initials: NK
authors.lastname: Razumova
authors.forename: T I
authors.initials: TI
authors.lastname: Masilianskaia
authors.forename: O B
authors.initials: OB
authors.lastname: Ariskina
authors.forename: O G
authors.initials: OG
authors.lastname: Guĭda
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007376:Interleukin-2 / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy* / Q000401:mortality; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D013997:Time Factors
chemical_list: D007376:Interleukin-2
vernacular_title: Interleĭkin-2 v kompleksnoĭ detoksikatsionnoĭ terapii khirurgicheskogo sepsisa.