title: Influence and interference of isosorbide dinitrate and food intake on superior mesenteric artery impedance in humans.
abstract: The influence of isosorbide dinitrate (ISDN) and food ingestion on superior mesenteric artery impedance was investigated in 24 healthy volunteers (age 40 +/- 2.7 years). Superior mesenteric artery circulation was assessed by duplex ultrasound. Pulsatility index (PI) was considered as a parameter of vascular resistance and was calculated as the peak-to-peak amplitude of the waveform divided by the mean amplitude. The subjects were randomly allocated to four groups (ISDN, meal, ISDN + meal, meal + ISDN). PI measurements were performed in resting and fasting conditions and serially for 1 h after sublingual 5 mg ISDN, ingestion of a 300-kcal, 300-ml mixed liquid meal; sublingual 5 mg ISDN followed 10 min later by the test meal; and ingestion of the test meal followed 5 min later by sublingual 5 mg ISDN. Five minutes after 5 mg sublingual ISDN, PI had increased from 6.8 to 12.4, while after intake of a meal PI had decreased from 7.6 to 4.9. Separate effects of 5 mg ISDN and meal intake lasted for at least 1 h. The reflex vasoconstrictive effect of 5 mg ISDN on the superior mesenteric artery circulation was counterbalanced by ingestion of a meal in healthy volunteers.
authors.affiliation: Department of Cardiology and Angiology, University Hospital, Gent, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Voet
authors.forename: S
authors.initials: S
authors.lastname: Mareels
authors.forename: M
authors.initials: M
authors.lastname: Afschrift
authors.forename: M
authors.initials: M
authors.lastname: De Buyzere
authors.forename: E
authors.initials: E
authors.lastname: Rietzschel
authors.forename: D
authors.initials: D
authors.lastname: Duprez
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D017097:Electric Impedance; D005502:Food; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D017538:Mesenteric Artery, Superior / Q000187:drug effects* / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D007548:Isosorbide Dinitrate