Hematopoietic growth factor receptors: structure variations and alternatives of receptor complex formation in normal hematopoiesis and in hematopoietic disorders.
Receptors of most hematopoietic growth factors are structurally related and grouped in the hematopoietin or cytokine receptor superfamily. In this paper, we will first review the general principles of hematopoietin receptor complex formation and cytoplasmic signaling. Subsequently, the significance of defective hematopoietic growth factor receptors for the development of hematological diseases will be discussed.
Budel
L M
LM
Dept. of Pathology, Erasmus University, Rotterdam, The Netherlands.
Dong
F
F
Löwenberg
B
B
Touw
I P
IP
D000595:Amino Acid Sequence; D000818:Animals; D006133:Growth Substances / Q000737:chemistry*; D006410:Hematopoiesis; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D011940:Receptor Aggregation; D016184:Receptors, Colony-Stimulating Factor / Q000737:chemistry*; D015398:Signal Transduction
D006133:Growth Substances; D008024:Ligands; D016184:Receptors, Colony-Stimulating Factor