title: Surfactant replacement therapy in neonates with respiratory failure due to bacterial sepsis.
abstract: We describe four newborns (gestational ages 29-37 weeks; birthweights 1380-3040 grams) who were mechanically ventilated for respiratory insufficiency because of bacterial sepsis. A beneficial effect of bovine surfactant (Alvofact, dosages 50 or 100 mg/kg) was found, as shown by decreases in mean airway pressures and oxygen demands. No side effects were seen after instillation.
authors.affiliation: Department of Pediatrics, Sophia Hospital, Zwolle, The Netherlands.
authors.forename: W P
authors.initials: WP
authors.lastname: Fetter
authors.forename: W
authors.initials: W
authors.lastname: Baerts
authors.forename: A P
authors.initials: AP
authors.lastname: Bos
authors.forename: R A
authors.initials: RA
authors.lastname: van Lingen
mesh_terms: D001424:Bacterial Infections / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids / Q000627:therapeutic use*; D008297:Male; D010743:Phospholipids; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012129:Respiratory Function Tests
chemical_list: D008055:Lipids; D010743:Phospholipids; D011663:Pulmonary Surfactants; C078272:SF-RI 1, bovine surfactant preparation