title: [Accidents of chemotherapy involving the upper limb].
abstract: Subcutaneous extravation of antimitotic agents in the upper limb is a rare complication of chemotherapy. The functional integrity of the limb can be compromised due to severe skin damage. Extensive soft tissue necrosis is difficult to manage and cannot always be repaired without sequellae. Based on an analysis of a series of patients and a review of the literature, we report the main pathophysiological features and clinical signs of such accidents as well as the still debated therapeutic management. Two points are essential: the emergency situation created by these accidents requiring adequate and rapid treatment despite the apparently benign appearance of the extravation and imperative prevention which is the main therapeutic tool.
authors.affiliation: Service de Chirurgie Plastique, Hôpital de la Conception, Marseille.
authors.forename: D
authors.initials: D
authors.lastname: Casanova
authors.forename: J P
authors.initials: JP
authors.lastname: Aubert
authors.forename: J
authors.initials: J
authors.lastname: Bardot
authors.forename: R
authors.initials: R
authors.lastname: Legré
authors.forename: G
authors.initials: G
authors.lastname: Magalon
authors.forename: H
authors.initials: H
authors.lastname: Bureau
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001132:Arm; D004317:Doxorubicin / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications* / Q000601:surgery; D006801:Humans; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000209:etiology* / Q000601:surgery; D013524:Surgical Flaps
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin
vernacular_title: Les accidents de la chimiothérapie au niveau du membre supérieur.