[Study of the anti-HIV activity of miramistin].
The anti-HIV activity of a cationic detergent myramistin and nonionic detergent dezintegron-0 (d-0) was studied using HIV-1 strains III B/H9 and BRU in lymphoblastoid cells MT-4 and Jurkat-tat. Myramistin in a concentration of 0.075 mg/ml was shown to prevent HIV-1 replication in MT-4 when these cells were cocultivated with the cells preinfected and treated with the detergent. Myramistin in concentrations from 0.030 to 0.050 mg/ml delayed the accumulation of virus antigens in the cells by 4 and 14 days, respectively, without preventing the infection of intact cells. Nonionic d-0 prevented HIV-1 infection of intact Jurkat-tat cells at a concentration of 12.5 mg/ml.
Krivorutchenko
Iu L
IuL
KrivosheinIuS
Marennikova
S S
SS
Stepanova
L G
LG
Nosik
D N
DN
Kalnina
L B
LB
Rud'ko
A P
AP
D000998:Antiviral Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D002460:Cell Line; D003497:Cyclic N-Oxides / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001548:Benzalkonium Compounds; D003497:Cyclic N-Oxides; D003902:Detergents; C066010:desintegron O; C058048:miramistin
Izuchenie anti-VICh-aktivnosti miramistina.