Disseminated intravascular coagulation after liver resection: retrospective study in patients with biliary tract carcinoma.
BACKGROUND
Disseminated intravascular coagulation (DIC) after hepatectomy is not well understood. The objective of this retrospective study was to evaluate hemostatic changes after extensive liver resection and to elucidate the frequency of posthepatectomy DIC.


METHODS
In 100 patients without cirrhosis who underwent resection of two or more segments of the liver for biliary tract carcinoma, various hemostatic parameters were measured before and after resection, and the liver function of each patient was assessed.


RESULTS
In patients with posthepatectomy liver failure, platelet count, fibrinogen concentrations, and prothrombin time were significantly lower than in those without such failure. Serum levels of fibrin degradation product did not differ significantly between the two groups. The minimum platelet count was significantly negatively correlated with serum total bilirubin level. Posthepatectomy DIC occurred in 2.0% of the patients.


CONCLUSIONS
After extensive liver resection patients exhibited a decreased platelet count with hepatic dysfunction. However, this condition rarely resulted in DIC, at least in patients without cirrhosis and serious postoperative complications.
Nagino
M
M
First Department of Surgery, Nagoya University School of Medicine, Japan.
Nimura
Y
Y
Hayakawa
N
N
Kamiya
J
J
Kondo
S
S
Miyachi
M
M
Kanai
M
M
D000328:Adult; D000368:Aged; D001661:Biliary Tract Neoplasms / Q000601:surgery*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008099:Liver / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011183:Postoperative Complications; D011184:Postoperative Period; D012189:Retrospective Studies