title: [Hypertrophic osteoarthropathy in a patient with nasopharyngeal carcinoma].
abstract: A clinic-pathological study of a 12 year-old male diagnosed of non-differentiated nasopharyngeal carcinoma (NPC) was carried out. The patients presented secondary hypertrophic osteoarthropathy prior to the development of lung metastases. Hypertrophic osteoarthropathy is a clinic-radiological syndrome characterized by a neoformation of periosteal bone, fundamentally located in long bones and distal ends of metacarpal bones. Polyarticular and synovial involvement is also observed. Association between NPC and hypertrophic osteoarthropathy is uncommon and appears to suggest the existence of metastatic spread (probably to the lung), particularly in young patients.
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia.
authors.forename: F J
authors.initials: FJ
authors.lastname: Vera Sempere
authors.forename: M S
authors.initials: MS
authors.lastname: Botella Rodríguez
authors.forename: F
authors.initials: F
authors.lastname: Aparisi Mocholi
authors.forename: C
authors.initials: C
authors.lastname: Morera Pérez
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary; D002277:Carcinoma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D011879:Radiotherapy Dosage
vernacular_title: Osteoartropatía hipertrófica en paciente con carcinoma de nasofaringe.