title: Estrogen rapidly induces c-jun immunoreactivity in rat striatum.
abstract: Estrogen has been reported to exert rapid effects on the function of neurons located in various brain regions, including those where classical estrogen receptors are not abundant, such as the striatum. The mechanism underlying these actions is not well understood, but does not appear to involve classical estrogen receptor-mediated genomic mechanisms. Estrogen has also been shown to regulate expression of immediate-early gene products in many tissues. In the present study, immunohistochemical methods were used to determine whether estrogen modulates the appearance of c-jun immunoreactivity (IR) in the striatum of rats. Administration of estradiol (100 micrograms/rat) to ovariectomized rats for 15 min induced a rapid and transient increase in c-jun-IR in the dorsomedial striatum and the core region of the nucleus accumbens. These data suggest that c-jun may serve as one of the rapidly responding mediators of estrogen action in the striatum and nucleus accumbens.
authors.affiliation: Department of Pharmacology, University of Washington, Seattle, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: D M
authors.initials: DM
authors.lastname: Dorsa
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000033:anatomy & histology*; D004967:Estrogens / Q000502:physiology*; D004971:Estrus / Q000235:genetics* / Q000502:physiology; D005260:Female; D015870:Gene Expression / Q000502:physiology; D007124:Immunoenzyme Techniques; D009714:Nucleus Accumbens / Q000033:anatomy & histology*; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014158:Transcription, Genetic
chemical_list: D004967:Estrogens; D016755:Proto-Oncogene Proteins c-jun