Efficacy of AmBisome in murine coccidioidomycosis.
ICR mice were infected intranasally with arthroconidia of Coccicioides immitis. Mice were treated intravenously with amphotericin B deoxycholate (Fungizone) or an amphotericin B-lipid vehicle (AmBisome). Doses ranged from 0.05 to 1.0 mg kg-1. Lung weight, which parallels disease severity and fungal burden in this infection, was used as the index of protection. Both Fungizone and AmBisome were significantly and equally protective at 0.3 and 1.0 mg kg-1 body weight.
Albert
M M
MM
Department of Medicine, Audie L. Murphy V. A. Hospital, San Antonio, Texas 78284, USA.
Adams
K
K
Luther
M J
MJ
Sun
S H
SH
Graybill
J R
JR
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D003047:Coccidioidomycosis / Q000188:drug therapy*; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR
C068538:liposomal amphotericin B; D000666:Amphotericin B