title: Thrombotic thrombocytopenic purpura and myoglobinuric acute renal failure following radiation therapy in a patient with polymyositis and cervical cancer.
abstract: A 73-year-old woman was admitted to receive radiation treatment for uterine cervical cancer, however a complex series of events ensued, leading to death. She developed an acute exacerbation of polymyositis complicated by thrombotic thrombocytopenic purpura, rhabdomyolysis and acute renal failure. Radiation therapy may have produced an immune disturbance leading to the acute exacerbation of polymyositis. Auto-immune-mediated endothelial damage might have triggered a series of events leading to thrombotic thrombocytopenic purpura. Rhabdomyolysis seemed to be the main cause of acute renal failure.
authors.affiliation: Third Department of Internal Medicine, Okayama University Medical School.
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Nagake
authors.forename: K
authors.initials: K
authors.lastname: Moriwaki
authors.forename: S
authors.initials: S
authors.lastname: Hirakawa
authors.forename: T
authors.initials: T
authors.lastname: Katayama
authors.forename: H
authors.initials: H
authors.lastname: Yanai
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Akagi
authors.forename: Z
authors.initials: Z
authors.lastname: Ota
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000473:pathology; D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009212:Myoglobinuria / Q000097:blood / Q000150:complications* / Q000652:urine; D017285:Polymyositis / Q000150:complications* / Q000473:pathology; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*