The glutamate receptor subunit GLuR1 is expressed in gonadotrophs of the anterior pituitary and is regulated by gonadal feedback.
An antiserum raised against a synthetic peptide corresponding to the C-terminal amino acid sequence (880-907) of the cloned glutamate receptor protein GluR1 stained gonadotrophic cells in the adenohypophysis of normal male rats. The staining intensity was greatly increased in the hypertrophic gonadotrophs of long-term castrated rats. These results indicate that glutamate may act directly on pituitary gonadotrophs as a neuroendocrine modulator. Furthermore, the expression of GluR1 in gonadotrophs (and thus these cells' ability to respond to glutamate) may be regulated by gonadal factors.
Petrusz
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Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599, USA.
D000818:Animals; D001921:Brain / Q000276:immunology / Q000378:metabolism; D005246:Feedback; D005260:Female; D005786:Gene Expression Regulation; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D017470:Receptors, Glutamate / Q000096:biosynthesis* / Q000235:genetics
D017470:Receptors, Glutamate; D018698:Glutamic Acid