[Effect of artemether on glycogen, protein, alkaline phosphatase and acid phosphatase of Schistosoma japonicum].
When mice infected with Schistosoma japonicum for 32-35 d were treated ig with artemether (Art) at a single dose of 300 mg.kg-1 for 24 h, the glycogen content of female and male schistosomes decreased significantly with reduction rates of about 50%. 72 h after medication, the glycogen reduction rates were 64.1-77.9%. Meantime, the protein content of female and male worms was also decreased, the reduction rates being 68.1% and 49.3%, respectively. In infected mice treated ig with Art at the same dosage for 24 h, the inhibition rates of alkaline phosphatase (AKP) activity in female and male worms were 30% and 25%, respectively. 72 h later, the AKP activity of female worm was further inhibited to 62.3% as compared with the control. Besides, the inhibitory effect of Art on acid phosphatase (ACP) activity of female worm was also more apparent than that of male worm. 72 h after medication, the respective inhibition rates of ACP activity in female and male worms were 75.7% and 47.6%. The results indicated that Art might exert its effect on both carbohydrate and protein metabolism of schistosomes.
You
J
J
Chinese Academy of Preventive Medicine, WHO Collaborating Center for Malaria, Schistosomiasis and Filariasis, Shanghai.
Guo
H
H
Mei
J
J
Jiao
P
P
Feng
J
J
Yao
M
M
Xiao
S
S
D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D000077549:Artemether; D037621:Artemisinins; D005260:Female; D006003:Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D015800:Protozoan Proteins / Q000378:metabolism*; D012549:Schistosoma japonicum / Q000187:drug effects* / Q000378:metabolism; D012554:Schistosomiasis japonica / Q000188:drug therapy* / Q000378:metabolism; D012556:Schistosomicides / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000494:pharmacology*
D037621:Artemisinins; D015800:Protozoan Proteins; D012556:Schistosomicides; D012717:Sesquiterpenes; D006003:Glycogen; D000077549:Artemether; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase