title: Solid alveolar rhabdomyosarcoma with a t(2;13).
abstract: We report a child with a progressive "solid alveolar rhabdomyosarcoma" in whom analysis of tumor cells revealed a t(2;13) translocation characteristic of the classical alveolar subtype. Both subtypes of alveolar rhabdomyosarcoma are associated with a poor response to treatment and the occurrence of this translocation in both is suggestive of a common biologic origin.
authors.affiliation: Department of Child Health, Medical School, Newcastle upon Tyne, U.K.
authors.forename: S M
authors.initials: SM
authors.lastname: Yule
authors.forename: N
authors.initials: N
authors.lastname: Bown
authors.forename: A J
authors.initials: AJ
authors.lastname: Malcolm
authors.forename: M M
authors.initials: MM
authors.lastname: Reid
authors.forename: A D
authors.initials: AD
authors.lastname: Pearson
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D002882:Chromosomes, Human, Pair 13; D002889:Chromosomes, Human, Pair 2; D003131:Combined Modality Therapy; D006801:Humans; D018232:Rhabdomyosarcoma, Alveolar / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D014178:Translocation, Genetic