title: Long-term histological evaluation of hydroxyapatite ceramics in humans.
abstract: We have investigated the interface between bone and hydroxyapatite (HA) chronically implanted in man. By light microscopy, HA appeared to bind directly to bone without intervening fibrous tissue. By transmission electron microscopy, two patterns were noted: (1) HA either bound directly to bone; or (2) electron-dense material intervened between HA and bone. The orientation of bone collagen fibres likewise showed two patterns: (1) collagen fibres were oriented parallel to the HA; or (2) the fibres were aligned perpendicularly. We have observed similar binding properties of HA to the jaw bone of humans in vivo and in vitro.
authors.affiliation: First Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Oguchi
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Mizoue
authors.forename: K
authors.initials: K
authors.lastname: Seto
authors.forename: G
authors.initials: G
authors.lastname: Eguchi
mesh_terms: D000328:Adult; D000540:Alveolar Ridge Augmentation; D002516:Ceramics / Q000737:chemistry*; D003094:Collagen / Q000378:metabolism / Q000648:ultrastructure; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000378:metabolism / Q000648:ultrastructure*; D008437:Maxilla / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D019736:Prostheses and Implants
chemical_list: D003094:Collagen; D017886:Durapatite