[Can TNF-alpha and IL-6 be helpful in assessment of chronic hepatitis in children?].
The purpose of the work was an assessment of TNF-alpha and Il-6 concentrations in 34 children with diagnosed chronic hepatitis. In all studied patients the values of TNF-alpha and Il-6 concentration were slightly increased. The correlations calculated between TNF-alpha and Il-6 concentrations calculated between TNF-alpha and Il-6 concentrations and laboratory parameters (laboratory indicators of hepatitis activity--AlAT; liver function indicators--prothrombin index, bilirubin concentration, bile acid concentration, alkaline phosphatase activity, anti-pyrin half-life) were non-significant in Spearman non-parametric test (p > 0.005) except for the correlation between albumin and TNF-alpha concentrations. No statistically significant differences of TNF-alpha and Il-6 concentrations were found between groups of patients with active and persistent hepatitis; groups with and without cirrhosis as well as between groups with and without portal hypertension. Normal or slightly increased TNF-alpha and Il-6 concentrations, observed in chronic hepatitis in children should be explained by compensated liver function in such patients.
Socha
P
P
Oddziału Gastroenterologii Centrum Zdrowia Dziecka.
Janas
R
R
Socha
J
J
Pawłowska
J
J
Woźniak
M
M
Woynarowski
M
M
D002648:Child; D002908:Chronic Disease; D006509:Hepatitis B / Q000097:blood*; D006526:Hepatitis C / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008111:Liver Function Tests; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
Czy TNF-alpha i IL-6 moga być pomocne w ocenie przewlekłego zapalenia watroby u dzieci?