title: Changes in thyroid hormone parameters after acute myocardial infarction.
abstract: Abnormalities in circulating thyroid hormone levels are very common in systemic nonthyroidal illnesses, such as acute myocardial infarction. In this study, thyroid parameters were determined in a series of 16 consecutive infarction patients treated by thrombolysis. Blood samples were taken before therapy as well as 2, 4, 6, 8, 12 and 72 h following admission. Total and free serum thyroxin and triiodothyronine decreased and reverse T3 increased significantly showing no major variations up to 72 h, whereas thyroid-stimulating hormone values remained almost unchanged during the observation period. Subjects with CK-MB levels of more than 150 ng/ml (n = 10) revealed similar changes in thyroid parameters in comparison to those with lower values (n = 6; NS). Thus, although hormone modifications very often occur following acute infarction, thyroid status may not serve as a marker for the extent of left ventricular dysfunction in the early phase of myocardial infarction.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Karl Franzens University of Graz, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Eber
authors.forename: M
authors.initials: M
authors.lastname: Schumacher
authors.forename: W
authors.initials: W
authors.lastname: Langsteger
authors.forename: R
authors.initials: R
authors.lastname: Zweiker
authors.forename: F M
authors.initials: FM
authors.lastname: Fruhwald
authors.forename: R
authors.initials: R
authors.lastname: Pokan
authors.forename: R
authors.initials: R
authors.lastname: Gasser
authors.forename: O
authors.initials: O
authors.lastname: Eber
authors.forename: W
authors.initials: W
authors.lastname: Klein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000201:enzymology / Q000503:physiopathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D007527:Isoenzymes; D013963:Thyroid Hormones; D014284:Triiodothyronine; D003402:Creatine Kinase; D013974:Thyroxine