Tau immunoreactivity associated with aluminum maltolate-induced neurofibrillary degeneration in rabbits.
Intracisternal administration of aluminum maltolate to rabbits produces a marked argyrophilic neurofibrillary degeneration (NFD) which is also immunoreactive for both phosphorylated and non-phosphorylated microtubule associated protein tau. Using tissue fixation in PBF, the monoclonal antibodies Tau-2 and AT8 stain the NFD. Dephosphorylation markedly reduces the positivity of AT8. Using PLP-fixed tissue, monoclonal antibody Tau-1 also immunostains aluminum-induced NFD.
Savory
J
J
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.
Huang
Y
Y
Herman
M M
MM
Reyes
M R
MR
Wills
M R
MR
D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies; D001921:Brain / Q000276:immunology; D007150:Immunohistochemistry; D008526:Medulla Oblongata / Q000276:immunology; D008636:Mesencephalon / Q000276:immunology; D009410:Nerve Degeneration; D016874:Neurofibrillary Tangles / Q000276:immunology / Q000648:ultrastructure*; D011817:Rabbits; D016875:tau Proteins / Q000276:immunology*
D000906:Antibodies; D016875:tau Proteins; D000535:Aluminum