[Epidemiological study of blood stasis and plasma tissue plasminogen activator and its inhibitor activity in healthy aged].
According to the blood stasis survey of 77 healthy subjects in presenile geriatric period, in comparison with 35 healthy young people, it was found the 51.79% of healthy subjects had blood stasis. The detectable rate were significantly different among various age groups (P < 0.005), and the rate increase was age-dependent. Chromogenic peptide substrate analytical method was used to detect plasma tissue plasminogen activator (t-PA), tissue plasminogen activator inhibitor (PAI) activity and ratio of P/t. The result revealed that the activity of plasma t-PA in presenile geriatric period subjects was significantly higher than that of young people (P < 0.01), but the activity of PAI had no difference in various age groups, and the ratio of P/t was markedly decreased. It showed that this was the physiological compensatory reaction of aging organism against hypercoagulability, and it was an effective way to maintain the physiological balance of the aged.
Liangmin
L D
LD
Fujian Union Hospital, Fuzhou.
Lu
L H
LH
Zhang
X M
XM
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood*
D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator