[Effects of furyl-dihydropyridine I on coronary collateral circulation in myocardial infarction of dogs].
Effects of furyl-dihydropyridine I (FDP-1) on collateral circulation were observed in ischemic myocardium of dogs. FDP-1 (200 micrograms.kg-1) of intracoronary injection increased collateral flow, reduced systemic artery resistance, and coronary systolic pressure in infarcted region and the area of infarction decreased from 28.9 +/- 1.3% to 15.3 +/- 1.2% (P < 0.01, n = 6). The results indicated that FDP-1 could improve coronary collateral circulation, increase collateral flow in ischemic region, decrease collateral flow in ischemic region, decrease myocardial oxygen demand, and protect myocardial ischemia.
Jia
M J
MJ
Department of Gerontology, Xijing Hospital, China.
Chen
S L
SL
Liao
Y L
YL
Liu
D Q
DQ
Li
L S
LS
Zhao
N P
NP
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003097:Collateral Circulation / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004095:Dihydropyridines / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C071424:2,6-dimethyl-4-furyl-1,4-dihydropyridine-5-dicarboxylate