Selective reconstitution of CD8+ cytotoxic T lymphocyte responses in immunodeficient bone marrow transplant recipients by the adoptive transfer of T cell clones.
The adoptive transfer of T cells specific for antigens encoded by pathogens and tumors has been an effective treatment for infections and malignancies in animal models and is potentially applicable for infections occurring in immunodeficient bone marrow transplant recipients. This article reviews recent insights derived from studies of the immunobiology of human cytomegalovirus (CMV) infection in healthy and immunodeficient hosts and the development of adoptive immunotherapy as prophylaxis for CMV infection in recipients of allogeneic bone marrow transplants.
Riddell
S R
SR
Fred Hutchinson Cancer Research Center, Columbia.
Walter
B A
BA
Gilbert
M J
MJ
Greenberg
P D
PD
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002478:Cells, Cultured / Q000637:transplantation; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy / Q000635:transmission; D006801:Humans; D017874:Immediate-Early Proteins / Q000276:immunology; D007121:Immunocompetence; D016867:Immunocompromised Host; D016056:Immunodominant Epitopes / Q000276:immunology; D016219:Immunotherapy, Adoptive; D008231:Lymphopenia / Q000150:complications / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000637:transplantation*; D015678:Viral Structural Proteins / Q000276:immunology
D000956:Antigens, Viral; D017874:Immediate-Early Proteins; D016056:Immunodominant Epitopes; D015678:Viral Structural Proteins