Immunoglobulin-like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge Geodia cydonium.
We have isolated and characterized two cDNAs from the marine sponge Geodia cydonium coding for a new member of a receptor tyrosine kinase of class II. The deduced amino acid sequence shows two characteristic domains: (i) the tyrosine kinase domain; and (ii) an immunoglobulin-like domain. The latter part shows high homology to the vertebrate C2 type immunoglobulin domain. This result demonstrates that immunoglobulin domains are not recent achievements of higher animals but exist also in those animals which have diverged from other organisms about 800 million years ago.
Schäcke
H
H
Institut für Physiologische Chemie, Universität, Mainz, Germany.
Rinkevich
B
B
Gamulin
V
V
Müller
I M
IM
Müller
W E
WE
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D018076:DNA, Complementary / Q000235:genetics; D007136:Immunoglobulins / Q000737:chemistry; D008969:Molecular Sequence Data; D005810:Multigene Family; D011161:Porifera / Q000201:enzymology*; D017434:Protein Structure, Tertiary; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D007136:Immunoglobulins; D020794:Receptor Protein-Tyrosine Kinases