title: [Immune status of adult population of the Bryansk region living in territory polluted by radionuclides].
abstract: Clinical and immunological investigation with immune status evaluation of three groups of adult population of Bryansk Region was performed. The first group included 165 persons living in Vyshkov (settlement of town type in Bryansk Region) contaminated with radionuclides as a result of Chernobyl accident. The second group included 68 persons living in Vyshkov, immunological monitoring of those was performed. The third group consisted of 114 persons living on the "clean" area of Pochep (Bryansk Region). On both areas (contaminated Vyshkov and "clean" Pochep) the large percent of persons (three quarters of all investigated ones) had clinical manifestations of immune deficiency. The immune status of Vyshkov inhabitants was characterized by T-helper/inductor activation. That was expressed in significant increase of CD4+, CD4+/CD8+ in comparison of control group of primary donors and to "clean" Pochep inhabitants and in stable decrease of average values of serum IgG in comparison to control group, IgG and IgM in comparison to Pochep group. Maximum high values of T-helpers under lowest T-suppressor/killer values were observed at clinical symptoms which may be stipulated by radiation factor (loss of hair and teeth, surplus weight, predisposition to bleedings) and in persons working in cattle-breeding.
authors.forename: I V
authors.initials: IV
authors.lastname: Oradovskaia
authors.forename: I D
authors.initials: ID
authors.lastname: Fadeeva
authors.forename: N V
authors.initials: NV
authors.lastname: Ul'ianova
authors.forename: M F
authors.initials: MF
authors.lastname: Nikonova
authors.forename: M M
authors.initials: MM
authors.lastname: Litvina
authors.forename: M V
authors.initials: MV
authors.lastname: Lavdovskaia
authors.forename: L F
authors.initials: LF
authors.lastname: Chernetsova
authors.forename: N V
authors.initials: NV
authors.lastname: Khoroshilova
mesh_terms: D000328:Adult; D015704:CD4 Antigens / Q000032:analysis; D016516:CD4-CD8 Ratio; D002588:Cesium Radioisotopes; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D015166:Monitoring, Immunologic; D011210:Power Plants; D018788:Radioactive Hazard Release; D012426:Russia; D013601:T-Lymphocytes / Q000276:immunology; D014455:Ukraine
chemical_list: D015704:CD4 Antigens; D002588:Cesium Radioisotopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Immunnyĭ status vzroslogo naseleniia Brianskoĭ oblasti, prozhivaiushchego na territoriiakh, zagriaznennykh radionuklidami.