Effects of choline and ethanolamine on the synthesis and breakdown of the inositol phospholipid (PI) system in Tetrahymena.
Lower concentrations of choline chloride and ethanolamine (10(-3) M; 10(-5) M) increased phosphatidyl inositol (PI), phosphatidyl inositol monophosphate (PIP) and phosphatidyl inositol bisphosphate (PIP2) level of Tetrahymena, while higher concentrations (10(-2) M) decreased them. These two substances also influenced, however in a less obvious way, the transformation of inositol phospholipids. The experiments draw attention to the sensitivity of the precursors of the second messenger system at a phylogenetically low level.
Kovács
P
P
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Csaba
G
G
D000818:Animals; D002794:Choline / Q000494:pharmacology*; D019856:Ethanolamine; D004983:Ethanolamines / Q000494:pharmacology*; D008563:Membrane Lipids / Q000378:metabolism; D008954:Models, Biological; D010716:Phosphatidylinositols / Q000378:metabolism*; D010802:Phylogeny; D015290:Second Messenger Systems; D013769:Tetrahymena pyriformis / Q000187:drug effects* / Q000502:physiology
D004983:Ethanolamines; D008563:Membrane Lipids; D010716:Phosphatidylinositols; D019856:Ethanolamine; D002794:Choline