IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1 and IgG3 subclasses.
Increased titers of IgG anti-GM1 and anti-asialo GM1 (GA1) ganglioside antibodies are present in some patients with the Guillain-Barré syndrome, particularly with the motor axonal variant, and following infection with Campylobacter jejuni or parenteral administration of gangliosides. The subclass distribution of IgG anti-GM1 or GA1 antibodies from 19 patients with acute motor neuropathy and elevated antibody titers were measured by ELISA using mouse monoclonal antibodies specific for human IgG subclasses. The anti-GM1 or GA1 antibodies were predominantly of the IgG1 and IgG3 subclasses, which are capable of complement fixation, and are characteristic of a T cell-dependent antibody response.
Ogino
M
M
Department of Neurology, Columbia Presbyterian, Medical Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Orazio
N
N
Latov
N
N
D002169:Campylobacter Infections / Q000276:immunology*; D016123:Campylobacter jejuni; D004797:Enzyme-Linked Immunosorbent Assay; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification* / Q000302:isolation & purification; D016472:Motor Neuron Disease / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology
D007074:Immunoglobulin G; D005677:G(M1) Ganglioside