Annexin VI has tumour-suppressor activity in human A431 squamous epithelial carcinoma cells.
In this study we show that heterologous expression of annexin VI in A431 squamous carcinoma cells caused a marked suppression of tumour cell growth when cells were cultured subcutaneously in nude mice. The tumours formed by the annexin VI+ A431 cells were morphologically and histologically similar to those formed by the wild-type cells.
Theobald
J
J
Department of Physiology, University College London, UK.
Hanby
A
A
Patel
K
K
Moss
S E
SE
D000818:Animals; D017317:Annexin A6 / Q000032:analysis / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D002460:Cell Line; D002999:Clone Cells; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008819:Mice, Nude; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D017317:Annexin A6