[Hypotensive action of 0.5% carteolol versus 0.1% timolol in patients with intraocular hypertension].
OBJECTIVE
The aim of the study was to compare 2 beta-blocker eye drops at a low concentration: 0.5% carteolol and 0.1% timolol.


METHODS
The study was designed as a random-order, double-blinded comparison of 2 parallel treatment groups. Fifty patients with early primary open angle glaucoma or high intraocular pressure were included. The treatment lasted 4 weeks, on the basis of 1 drop twice daily. Diurnal I.O.P. curve was assessed with 4 measurements from 8.30 a.m. to 4.30 p.m. before and after treatment. The 8.30 a.m. measure of the final assessment of I.O.P. curve was established prior to morning medication. The mean values of the 4 measures were compared.


RESULTS
Both treatments reduced IOP by a comparable amount: 4.25 +/- 1.2 mmHg (mean +/- SD) for carteolol and 4.69 +/- 1.9 mmHg for timolol. The decrease of IOP was found at every time of assessment, without any significant difference between treatments. Both eye drops were very well tolerated.


CONCLUSIONS
The results of this study show that the new beta-blocker eye drop solution 0.5% carteolol is effective for initial management of high intraocular pressure.
Allaire
C
C
Laboratoire Chauvin, Montpellier.
Trinquand
C
C
Nordmann
J P
JP
Dascotte
J C
JC
George
J L
JL
Lesure
P
P
Rouland
J F
JF
Khaitrine
L
L
Sirbat
D
D
D000328:Adult; D002354:Carteolol / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy*; D011446:Prospective Studies; D013999:Timolol / Q000627:therapeutic use*
D013999:Timolol; D002354:Carteolol
Action hypotensive du cartéolol 0.5% versus timolol 0.1% chez les patients porteurs d'une hypertonie intraoculaire.