title: The ion parametric resonance model predicts magnetic field parameters that affect nerve cells.
abstract: An ion parametric resonance (IPR) model recently developed by Blanchard and Blackman predicts distinct magnetic field interactions with biological systems based on a selective relation among four factors: the flux density of the static magnetic field, the frequency and flux density (Bac) of the parallel ac magnetic field, and the charge-to-mass ratio of ions of biological relevance. To test this model, PC-12 cells stimulated by nerve growth factor to produce neurites were exposed for 23 h in a 5% CO2 incubator using a multiple-coil exposure system to produce 45 Hz ac and dc (366 mG parallel to ac; less than 2 mG perpendicular to ac) magnetic fields. Our earlier work showed a cycle of inhibition/no inhibition of neurite outgrowth consistent with the IPR model predictions for Bac exposures between 0 and 468 mG rms. The work described here tests neurite outgrowth over a broader range of Bac (233-1416 mG rms). The experimental results remain consistent with earlier results, and with IPR model predictions of a second cycle of inhibition, return to control values, followed by a third cycle of inhibition of neurite outgrowth. These responses support the fundamental relationships predicted by the IPR model. The results have broad significance for biology.
authors.affiliation: Health Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711-2055, USA.
authors.forename: C F
authors.initials: CF
authors.lastname: Blackman
authors.forename: J P
authors.initials: JP
authors.lastname: Blanchard
authors.forename: S G
authors.initials: SG
authors.lastname: Benane
authors.forename: D E
authors.initials: DE
authors.lastname: House
mesh_terms: D000818:Animals; D055590:Electromagnetic Phenomena; D004578:Electron Spin Resonance Spectroscopy; D008280:Magnetics; D008962:Models, Theoretical; D009414:Nerve Growth Factors / Q000502:physiology; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D016716:PC12 Cells; D051381:Rats
chemical_list: D009414:Nerve Growth Factors