Synthesis and pharmacological evaluation of 1,2,4-triazine and its congeners.
3-[Mercapto]-n-propanoxy/methyl-ethanoxy branched chain in 5,6-Diphenyl- 1,2,4-triazine were condensed with O-phenylene diamine or O- aminophenol or o-aminothiophenol. The carboxylic groups of the synthesized compounds were cyclised to yield imidazoles, oxazoles and thiazoles. They were screened for their anti-inflammatory response in albino rats against carrageenin induced paw oedema. The active compounds were also evaluated for their ED50 value in albino rats and analgesic activity in albino mice. The compounds exhibited significant anti-inflammatory activity also showed marked protection against aconitine induced writhing response. The potent compounds showed high LD50 values.
Bhalla
M
M
Department of Pharmacology and Therapeutics K.G.'s Medical College Lucknow, India.
Srivastava
V K
VK
Bhalla
T N
TN
Shanker
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007536:Isomerism; D051379:Mice; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014227:Triazines; C093444:1,2,4-triazine