title: Topological approach to drug design.
abstract: In this paper we demonstrated that by an adequate combination of different topological indices it is possible to select and design new active compounds in different therapeutical scopes, with a very high efficiency level. Particularly successful in the search of new "lead drugs", the results show the surprising ability of the topological methods to describe molecular structures.
authors.affiliation: Department of Physical Chemistry, Faculty of Pharmacy, University of Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Gálvez
authors.forename: R
authors.initials: R
authors.lastname: García-Domenech
authors.forename: J V
authors.initials: JV
authors.lastname: de Julián-Ortiz
authors.forename: R
authors.initials: R
authors.lastname: Soler
mesh_terms: D000818:Animals; D017076:Computer-Aided Design; D016002:Discriminant Analysis; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D004364:Pharmaceutical Preparations