[The inhalation of low concentrations of manganese powders produces changes in respiratory mucociliary clearance].
The aim of this study is to verify whether inhaling metallic dusts, containing a lower concentration of Mn (as Mn3O4) than current TLV can cause alterations in exposed workers tracheobronchial mucociliary clearance. We studied 20 grinders using an 11.5-13% Mn steel, and a control group of 21 standard steel grinders, employed in the same foundry. Environmental Mn dust was measured by personal samplers. All workers were administered a questionnaire about chronic bronchitis; the following examinations were also carried out: medical examination, spirometry, chest standard X-ray and urinary Mn dosage. Mucociliary clearance was measured by human respiratory mucus transportability on frog palate and expressed as normalized frog palate transport rate (NFPTR). Mucus was obtained through a sputum so protected as to avoid salivary contamination. Environmental measurements showed a Mn concentration from 0.1 to 1 mg/m3 with respect to a TLV of 5 mg/m3. Exposed workers and control group were homogeneous as far as age, working period, tobacco smoking habit and spirometric parameters are concerned. Chest X-ray examination showed no evidence of pneumoconiosis. Mn exposed workers showed a NFPTR reduction, if compared to normal level (0.70). NFPTR average value in exposed group has come out to be much lower than in control group. NFPTR alteration in Mn exposed group appears to be strictly linked to a longer than 15 years working seniority. Urinary Mn values resulted extremely low in each worker and their average was not significantly different between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Di Lorenzo
L
L
Istituto di Medicina del Lavoro, Università degli Studi di Bari.
Sacchitelli
F
F
Margiotta
M
M
Cassano
F
F
Elia
G
G
Pegorari
M M
MM
Soleo
L
L
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D004391:Dust / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D007558:Italy / Q000453:epidemiology; D017895:Manganese Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D008669:Metallurgy; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D016273:Occupational Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D010087:Oxides / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D012907:Smoking / Q000453:epidemiology; D013147:Spirometry / Q000706:statistics & numerical data
D000395:Air Pollutants, Occupational; D004391:Dust; D017895:Manganese Compounds; D010087:Oxides; C027424:manganese oxide
L'inalazione di basse concentrazioni di polveri di manganese determina alterazioni della clearance mucociliare respiratoria.