Effects of nandrolone propionate on experimental tumor growth and cancer cachexia.
We studied the tumor host response to excessive doses of an anabolic steroid (nandrolone propionate, 2.5 mg 20 g intraperitoneally every second day for 11 days) with respect to body composition and tumor cell kinetics in MCG 101 sarcoma-bearing mice (C57BL/6J) with progressive cachexia. Although survival and food intake were not affected, a significant weight gain was observed that was essentially attributed to water retention. Net protein content was increased only to a minor extent (15%), of which only the liver accounted for a significant part of the body compartments. Hepatic protein accumulation was obviously caused by decreased protein degradation, since hepatic RNA content was unchanged. After anabolic steroid administration, reduced histochemical staining of succinate dehydrogenase was observed in skeletal muscles rich in oxidative type 1 fibers, but it was not different from that of tumor-bearing control animals, which was also confirmed by measurements of citrate synthase and cytochrome c oxidase activities in skeletal muscle and liver tissue. The anabolic steroid had no significant effect on tumor growth in terms of weight progression, energy state, polyamine synthesis rate, cell division rate, and cell cycle cytocompartments. We conclude that anabolic steroid supplementation is not therapeutically beneficial in counteracting progressive weight loss in experimental cancer.
Lydén
E
E
Department of Otolaryngology, Wallenberg Laboratory, Sahlgrenska Hospital, University of Gothenburg, Sweden.
Cvetkovska
E
E
Westin
T
T
Oldfors
A
A
Soussi
B
B
Gustafsson
B
B
Edström
S
S
D045930:Anabolic Agents / Q000494:pharmacology; D000818:Animals; D001823:Body Composition; D002100:Cachexia / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000150:complications / Q000378:metabolism / Q000473:pathology*
D045930:Anabolic Agents; D009277:Nandrolone; C008580:nandrolone phenpropionate