Organic osmolytes in the kidney of domesticated red deer, Cervus elaphus.
The cortex, inner and outer medulla, and papilla of kidneys of domestic red deer were analysed. In hydrated animals the urine concentration was found to be 672 +/- 45 mOsm.l-1. The medullary and papillary regions of the kidney were rich in the osmolytes betaine, glycerophosphorylcholine (GPC), inositol and sorbitol, all of which showed a steep rise in concentration from cortex to papilla. The kidney was rich in free amino acids, in particular taurine, glutamate (+glutamine), glycine and alanine, which were present at concentrations sufficient to suggest a possible role as osmolytes.
Bedford
J J
JJ
Department of Physiology, University of Otago, Dunedin, New Zealand.
Smiley
M
M
Leader
J P
JP
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000829:Animals, Domestic; D001622:Betaine / Q000378:metabolism; D003670:Deer / Q000378:metabolism* / Q000652:urine; D005997:Glycerylphosphorylcholine / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D009994:Osmolar Concentration; D009995:Osmosis; D013012:Sorbitol / Q000378:metabolism; D013654:Taurine / Q000378:metabolism; D014018:Tissue Distribution
D000596:Amino Acids; D013654:Taurine; D001622:Betaine; D007294:Inositol; D013012:Sorbitol; D005997:Glycerylphosphorylcholine; D000409:Alanine; D005998:Glycine