title: Urinary 1-hydroxypyrene as biomarker of exposure to polycyclic aromatic hydrocarbons in workers in petrochemical industries: baseline values and dermal uptake.
abstract: The suitability of urinary 1-hydroxypyrene as a biomarker for the assessment of exposure to polycyclic aromatic hydrocarbons (PAH) in petrochemical industries was evaluated in 562 workers involved in various operations in petrochemical industries. The median 1-hydroxypyrene concentration in 121 of these workers (both smokers and non-smokers) who had had no recent occupational exposure to PAH was 0.11 mumol/mol creatinine. The upper limit of the 95% confidence interval was 0.51 mumol/mol creatinine. During activities with a low potential exposure to PAH, such as loading bitumen and the handling of clarified slurry oils and furfural extracts, 1-hydroxypyrene concentrations were only marginally increased compared with the values measured in the 121 workers with no recent occupational exposure to PAH. Despite the substantially higher potential exposure to PAH during clean-out operations of various oil refinery installations, the concentrations of 1-hydroxypyrene in the workers involved were in the same range. This suggests that personal protection equipment was generally adequate to prevent excessive exposure. However, in workers digging PAH-contaminated soil and workers engaged in the production of needle coke from ethylene cracker residue, significantly increased urinary 1-hydroxypyrene concentrations were measured. A major decrease in urinary 1-hydroxypyrene following the application of dermal protective equipment in the ground workers suggested that skin absorption plays a major role in occupational exposure to PAH. The excretion of 1-hydroxypyrene by the workers of the needle coke plant was investigated in relation to potential determinants of exposure to PAH. It was indeed found that not only inhalatory but also dermal exposure was a significant determinant of occupational exposure to PAH.
authors.affiliation: Shell Internationale Petroleum Maatschappij B.V., Health, Safety and Environment Division, The Hague, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Boogaard
authors.forename: N J
authors.initials: NJ
authors.lastname: van Sittert
mesh_terms: D000395:Air Pollutants, Occupational / Q000652:urine*; D004784:Environmental Monitoring; D006801:Humans; D001239:Inhalation; D008297:Male; D010578:Petroleum; D011083:Polycyclic Compounds / Q000652:urine*; D011721:Pyrenes / Q000378:metabolism*; D012869:Skin Absorption; D014556:Urine
chemical_list: D000395:Air Pollutants, Occupational; D010578:Petroleum; D011083:Polycyclic Compounds; D011721:Pyrenes; C033146:1-hydroxypyrene