[Leukemia associated with bimkolane].
Psoriatic patients and mice treated with bimolane were observed. The frequency of chromosomes aberration and micro-nuclear cells presence in the treated group (11 cases) was significantly higher than that in the control group (11 cases, P < 0.005; < 0.001). Study of lymphocytic subsets showed that value of CD4/CD8 in the peripheral blood of the treated group was lower than that of the control group (P < 0.05). The level of serum IgM in the treated group was also lower (P < 0.05). There were 10 mice suffering from leukemia (7 mice with acute promyelocytic leukemia) in a treated group of 40 mice of an inbred line of 615 mice, while there was no leukemia in a control group of 20 mice of the same species. The morbidity of leukemia in the treated mice was higher than that of controls (P < 0.05).
Ye
H
H
Affiliated Hospital, Shandong Medical University, Jinan.
Tu
Z H
ZH
Li
X F
XF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy; D011929:Razoxane / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012189:Retrospective Studies
C031186:bimolane; D011929:Razoxane