Apiosporamide, a new antifungal agent from the coprophilous fungus Apiospora montagnei.
Bioassay-guided fractionation of an EtOAc extract from the mycelium of the coprophilous fungus Apiospora montagnei has furnished a new antifungal metabolite, named apiosporamide [1], and the known dihydroisocoumarin cis-(3R,4R)-4-hydroxymellein [4]. The structure of 1 was assigned on the basis of HMBC, HMQC, NOESY, and hrms data. Elucidation of the structure was complicated by the fact that several nmr signals appeared only under certain conditions.
Alfatafta
A A
AA
Department of Chemistry, University of Iowa City 52242.
Gloer
J B
JB
Scott
J A
JA
Malloch
D
D
D000107:Acetylation; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003511:Cyclohexanols / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000302:isolation & purification* / Q000494:pharmacology; D013098:Xylariales / Q000737:chemistry*
D000935:Antifungal Agents; D003511:Cyclohexanols; D011728:Pyridones; C093028:apiosporamide