A selenium transport protein model of a sub-type of schizophrenia.
The model presented here suggests that a defect in a selenium transport protein may be a necessary but not sufficient precondition for a sub-type of schizophrenia--a type of schizophrenia that has been characterized by negative symptoms, brain damage, and a lack of primarily paranoid ideation. A defective selenium transport protein and consequent low levels of selenium might adversely affect multiple enzyme systems. Selenium-enzyme interreactions are discussed and the effect of selenium on arachidonic acid and its metabolites, especially 12-HPETE, are examined in light of the presented model. If the proffered model is essentially correct, selenoprotein P, a hypothesized selenium transport protein, is a likely candidate for a protein involved in the etiology of a form of schizophrenia.
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D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology; D004798:Enzymes / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D012559:Schizophrenia / Q000145:classification / Q000188:drug therapy / Q000378:metabolism*; D012565:Schizophrenic Psychology; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D051137:Selenium-Binding Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D014451:Ubiquinone / Q000378:metabolism
D002352:Carrier Proteins; D004798:Enzymes; D006893:Hydroxyeicosatetraenoic Acids; D011506:Proteins; D051137:Selenium-Binding Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D014451:Ubiquinone; D016718:Arachidonic Acid; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D005979:Glutathione Peroxidase; D012643:Selenium; C025204:Ubiquinone Q2; D004298:Dopamine