title: Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis.
abstract: Mean platelet survival time in patients with acute poststreptococcal glomerulonephritis (APSGN) is reduced to 50-60% of the control values, and glomerular deposits of platelet factor 4 are found in these patients. In order to investigate further systemic platelet changes of pathogenic, clinical or prognostic significance, we measured the platelet serotonin (5-HT) content and the blood platelet counts during the 1st week of the disease in 27 patients with APSGN. Platelet 5-HT was significantly reduced in patients with APSGN as compared with patients with impetigo without glomerular involvement (785 +/- 54 vs. 1,329 +/- 94 ng 5-HT/10(9) platelets; p < 0.001). Similarly, the mean blood platelet count was reduced to 247 +/- 16 x 10(3) as compared with 303 +/- 14 x 10(3) in the controls (p < 0.05). Thirteen (48%) of these patients had individual values of platelet 5-HT lower than the 95% confidence interval calculated in the control group. No significant correlation was observed between the concentration of 5-HT and either the severity of the disease judged by the amount of urinary protein excretion and the serum creatinine value or the presence of circulating immune complexes. Significant correction of the platelet 5-HT content (to 1,180 +/- 111 ng/10(9) platelets; p < 0.01) and of the platelet counts (to 309 +/- 21 x 10(3); p < 0.01) were observed in the longitudinal study at least 2 weeks later. Platelet activation, with secretion of granular content and increased consumption, may explain these findings. Additionally, the reduced mean age of the circulating platelets could contribute to their decreased 5-HT levels.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Nephrology, School of Medicine, Universidad Austral, Valdivia, Chile.
authors.forename: S
authors.initials: S
authors.lastname: Mezzano
authors.forename: M
authors.initials: M
authors.lastname: Kunick
authors.forename: F
authors.initials: F
authors.lastname: Olavarría
authors.forename: L
authors.initials: L
authors.lastname: Ardiles
authors.forename: E
authors.initials: E
authors.lastname: Aranda
authors.forename: D
authors.initials: D
authors.lastname: Mezzano
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000097:blood* / Q000276:immunology / Q000382:microbiology / Q000652:urine; D010976:Platelet Count; D011507:Proteinuria / Q000150:complications; D012701:Serotonin / Q000097:blood*; D013290:Streptococcal Infections / Q000150:complications*
chemical_list: D000936:Antigen-Antibody Complex; D012701:Serotonin; D003404:Creatinine