Acute and chronic losartan administration: effect on angiotensin II content and modulation of [3H]norepinephrine release from rat interscapular brown adipose tissue.
To determine if acute or chronic (21 days) losartan (10 mg/kg, s.c.) regulates the renin-angiotensin system in interscapular brown adipose tissue, angiotensin II (AII) content and [3H]overflow from slices preloaded with [3H]norepinephrine were examined. Acute or chronic losartan administration had no effect on AII content. AII increased evoked [3H] overflow from slices from control rats. Losartan administration did not alter basal [3H]outflow or evoked [3H]overflow. Acute losartan administration inhibited AII-induced enhancement of evoked [3H]overflow. Tolerance developed to the inhibitory effect of losartan following chronic administration.
Cassis
L A
LA
Division of Pharmacology and Experimental Therapeutics, College of Pharmacy, University of Kentucky, Lexington, USA.
Dwoskin
L P
LP
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001713:Biphenyl Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D007093:Imidazoles / Q000008:administration & dosage* / Q000494:pharmacology; D066298:In Vitro Techniques; D019808:Losartan; D008297:Male; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013777:Tetrazoles / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors; D014316:Tritium
D001713:Biphenyl Compounds; D007093:Imidazoles; D013777:Tetrazoles; D014316:Tritium; D000804:Angiotensin II; D019808:Losartan; D009638:Norepinephrine