Selective digestive decontamination in multiple trauma patients: cost and efficacy.
A double-blind randomized placebo-controlled study was carried out to evaluate the efficacy and the cost of selective digestive decontamination (SDD) to prevent nosocomial pneumonia in multiple-trauma patients. Nosocomial infections, particularly pneumonia, were more frequent in the placebo group. The most common infectious agent was Staphylococcus: Staphylococcus aureus in the placebo group and Staphylococcus epidermidis in the SDD group. Methicillin-resistant Staphylococcus epidermidis was detected more often in the SDD group. No methicillin-resistant Staphylococcus aureus was observed in this study. Fewer patients in the SDD group required antibiotherapy. SDD resulted in a saving of about 41% in drug expenditure.
Langlois-Karaga
A
A
Hôpital Nord, Chemin des Bourelly, Marseille, France.
Bues-Charbit
M
M
Davignon
A
A
Albanese
J
J
Durbec
O
O
Martin
C
C
Morati
N
N
Balansard
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003365:Costs and Cost Analysis; D003428:Cross Infection / Q000517:prevention & control*; D004064:Digestive System / Q000382:microbiology*; D004311:Double-Blind Method; D006801:Humans; D007902:Length of Stay; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000517:prevention & control*; D014947:Wounds and Injuries / Q000150:complications*
D000900:Anti-Bacterial Agents