title: [Adrenergic beta-2 receptors and cyclic AMP in lymphocytes and their relationship to uterine contractility].
abstract: It is especially in the long-term application where the pharmacodynamics of the betamimetics determine their effectiveness. According to the time and dosis, there is a decrease in the density and function of the beta 2-adrenoceptors (desensitization). Clinically, this means a loss of effectiveness. This study investigated whether in the course of a normal pregnancy (n = 22) there is a change in the effectiveness of the betamimetics, as expressed by a change in the number of beta 2-adrenoceptors or their function. The results show a 50% decrease in the number of beta 2-adrenoceptors to the 36th gestational week and an increase to initial values after delivery. A similar pattern is found for the function of the beta 2-adrenoceptors (cyclic AMP). The implications for the uterus might be that, with advancing pregnancy, it becomes less prone to relaxation and that the betaadrenergic system, as a mechanism supporting prepare the way for delivery at term, becomes less significant. For tocolysis with betamimetics, the decrease of the beta 2-adrenoceptor density means that, with increasing gestational age, the responsiveness of the uterus to betamimetics decreases.
authors.affiliation: Klinik und Poliklinik für Geburtshilfe, Universität Zürich.
authors.forename: U
authors.initials: U
authors.lastname: von Mandach
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000242:Cyclic AMP / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007745:Labor Onset / Q000187:drug effects / Q000502:physiology*; D008137:Longitudinal Studies; D007752:Obstetric Labor, Premature / Q000503:physiopathology / Q000517:prevention & control; D011247:Pregnancy; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects / Q000502:physiology*; D015145:Tocolysis; D014590:Uterine Contraction / Q000187:drug effects / Q000502:physiology*
chemical_list: D000318:Adrenergic beta-Agonists; D018343:Receptors, Adrenergic, beta-2; D000242:Cyclic AMP
vernacular_title: beta 2-Adrenozeptoren und zyklisches AMP in den Lymphozyten und ihre Beziehung zur Uteruskontraktilität.