title: Fluconazole penetration into the human prostate.
abstract: Fluconazole concentrations in the serum and prostate of human volunteers undergoing transurethral resection for benign prostatic hypertrophy were measured. There was a high correlation (r = 0.783) between serum (mean = 6.6 micrograms/ml) and tissue (mean = 1.9 micrograms/g) fluconazole concentrations, and these data were used to construct a model for local tissue concentrations.
authors.affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Finley
authors.forename: J D
authors.initials: JD
authors.lastname: Cleary
authors.forename: J
authors.initials: J
authors.lastname: Goolsby
authors.forename: S W
authors.initials: SW
authors.lastname: Chapman
mesh_terms: D003453:Cryptococcosis / Q000188:drug therapy; D015725:Fluconazole / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism*
chemical_list: D015725:Fluconazole