title: Uterine atrophy in chronic murine toxoplasmosis due to ovarian dysfunction.
abstract: Uterine atrophy is a conspicuous finding in Nya:NYLAR female mice chronically infected with Toxoplasma gondii. Administration of 17B-estradiol to infected mice induced a vigorous uterotropic response, i.e., an increase in uterine weight, in endometrial hypertrophy and proliferation, and in the activity of three estrogen-regulated uterine enzymes. These findings rule out a parasite-induced refractoriness of the uterus to estrogen and point to ovarian dysfunction (hypogonadism) as the immediate cause of the uterine atrophy.
authors.affiliation: Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201, USA.
authors.forename: W
authors.initials: W
authors.lastname: Stahl
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneda
authors.forename: M
authors.initials: M
authors.lastname: Tanabe
authors.forename: S A
authors.initials: SA
authors.lastname: Kumar
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism; D000818:Animals; D001284:Atrophy; D002455:Cell Division / Q000187:drug effects; D003402:Creatine Kinase / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D004717:Endometrium / Q000187:drug effects / Q000473:pathology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006984:Hypertrophy; D007527:Isoenzymes; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000503:physiopathology*; D014124:Toxoplasmosis, Animal / Q000473:pathology* / Q000503:physiopathology; D014599:Uterus / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*
chemical_list: D007527:Isoenzymes; D004958:Estradiol; D005954:Glucosephosphate Dehydrogenase; D003402:Creatine Kinase; D000263:Adenylate Kinase