title: [Evaluation of renal function using 99mTc-MAG3 comparison with 131I-OIH by simultaneous dual energy peak acquisition method].
abstract: A newly developed 99mTc-labeled renal scintigraphic and renographic agent, 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) was studied clinically and compared with 131I-OIH in 16 patients with various renal and urinary tract disorders. The abdominal aorta and the common iliac artery were clearly visualized in the vascular phase. The renogram patterns showed the same pattern in all cases. The parameters on the renogram such as Tmax, T2/3, T1/2 were compared. The highly significant correlations of Tmax, T2/3 and T1/2 were observed between 99mTc-MAG3 and 131I-OIH with correlation coefficient of 0.982, 0.907, 0.990, respectively. In all cases, excretion of 99mTc-MAG3 was slower than that of 131I-OIH and the ratios of Tmax, T2/3 and T1/2 between 99mTc-MAG3 and 131I-OIH were 1.113 +/- 0.121, 1.277 +/- 0.247, 1.179 +/- 0.075, respectively. It is concluded that 99mTc-MAG3 is useful renal imaging agent as an alternative to 131I or 123I-OIH.
authors.affiliation: Department of Radiology, School of Medicine, Keio University.
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: R
authors.initials: R
authors.lastname: Ishibashi
authors.forename: R
authors.initials: R
authors.lastname: Iwasaki
authors.forename: T
authors.initials: T
authors.lastname: Sanmiya
authors.forename: J
authors.initials: J
authors.lastname: Hashimoto
authors.forename: E
authors.initials: E
authors.lastname: Kunieda
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Kubo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes / Q000008:administration & dosage; D007465:Iodohippuric Acid / Q000008:administration & dosage; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011866:Radioisotope Renography / Q000379:methods; D017263:Technetium Tc 99m Mertiatide / Q000008:administration & dosage
chemical_list: D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide