Volume-activated chloride currents associated with the multidrug resistance P-glycoprotein.
The ability to regulate volume is an important property of most, if not all cells. In epithelial cells, amongst others, cell volume-activated chloride channels are central to this response. The molecular identities of these channels are not yet known. Expression of the human multidrug resistance P-glycoprotein (P-gp) has been associated with cell volume-regulated chloride currents, although the nature of this association is the subject of debate. Recent data indicate that P-gp acts by regulating the activation of an endogenous channel protein. In this review, evidence associating P-gp with cell volume-activated chloride currents, and the possible mechanisms by which this might be achieved, are discussed.
Higgins
C F
CF
Nuffield Department of Clinical Biochemistry, University of Oxford, John Radcliffe Hospital.
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000818:Animals; D018118:Chloride Channels / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018118:Chloride Channels