[The immune reconstitution in Scid mice and the effect of T, B, NK cells on the growth potential of CNE-2Z-H5 transplanted tumor].
CNE-2Z-H5 was transplanted into the Scid mice of which immune system was reconstituted with the peripheral lymphocytes or thymus of the isogenetic mice and the BALB/c nude mice of which NK cells were inhibited with cyclophosphamide. The results showed that the growth speed and weight of the tumors were in order from high to low among groups of Scid mice, BALB/c nude mice with NK inhibited, BALB/c nude mice, Scid mice with immune reconstitution. The transplanted tumor, in 6/6 cases injected beforehand with peripheral lymphocytes and 1/3 case transplanted accompanied with thymus disappeared within 22 days. The conclusion is that the immune reconstitution of Scid mice has succeeded and play an effective role in antitumor response.
Hu
X R
XR
Department of Pathology, Guangdong Medical College, Zhanjiang.
Shen
S J
SJ
Mo
M Y
MY
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D007694:Killer Cells, Natural / Q000276:immunology*; D017710:Lymphocyte Transfusion; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016513:Mice, SCID; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000473:pathology; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured