title: [Effect of copper and copper binding protein on the CT attenuation value of liver: experimental study in rats].
abstract: We analyzed the effect of copper and copper binding protein on CT attenuation value in a rat model. CT attenuation values of the liver were compared with hepatic copper content and grade of orcein-positive granules, which are thought to be a counterpart of polymerized methalothionein in lysosomes. The difference between hepatic copper and CT attenuation value was not statistically significant (R = 0.056, p = 0.96). CT value had a positive correlation with the grade of orcein-positive granules (Rho = 0.755, p = 0.0001). We concluded that the CT attenuation value of liver can be elevated by rich polymerized methalothionein (copper binding protein) in lysosomes.
authors.affiliation: Department of Radiology, Kanazawa University.
authors.forename: J
authors.initials: J
authors.lastname: Yoshikawa
authors.forename: O
authors.initials: O
authors.lastname: Matsui
authors.forename: M
authors.initials: M
authors.lastname: Akimoto
authors.forename: J
authors.initials: J
authors.lastname: Sanada
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Takashima
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D014057:Tomography, X-Ray Computed
chemical_list: D002352:Carrier Proteins; C023548:copper-binding protein; D003300:Copper