title: Synthesis of phthalimido-desmuramylpeptide analogues as potential immunomodulating agents.
abstract: The preparation of immunologically active phthalimido desmuramylpeptide analogues 2e-h, 4c-d, and 7b is described. The N-acetylmuramic acid in the muramyl dipeptide has been replaced by a phthaloylated acyclic moiety such as N-phthaloylated amino acids 1a-c, 2-(2-phthalimidoethoxy)acetic acid 3, or by the carbocyclic rac. trans-2-(2'-phthalimidocyclohexyloxy)acetic acid 6.
authors.affiliation: Department of Pharmacy, University of Ljubljana, Slovenia.
authors.forename: U
authors.initials: U
authors.lastname: Urleb
authors.forename: A
authors.initials: A
authors.lastname: Krbavcic
authors.forename: M
authors.initials: M
authors.lastname: Sollner
authors.forename: D
authors.initials: D
authors.lastname: Kikelj
authors.forename: S
authors.initials: S
authors.lastname: Pecar
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D010455:Peptides; D010797:Phthalimides; D003520:Cyclophosphamide