title: Hyper-dopaminemia may produce an increased outlet resistance of the prostatic urethra: a case report of malignant pheochromocytoma.
abstract: We report on a 43-year-old man with difficult urination attributed to malignant pheochromocytoma with hyper-dopaminemia. A decrease and increase in the plasma dopamine values during the clinical course clearly coincided with improvement and deterioration, respectively, in urination difficulty. The prostatic peak pressure decreased by 37% when the plasma dopamine value was minimal. Detrusor function was normal throughout. Endocrinological and urodynamic studies suggested that hyper-dopaminemia produced an increased outlet resistance of the prostatic urethra without altering detrusor function. Thus, peripheral dopaminergic systems may influence voiding mechanisms, especially those involving the proximal urethra.
authors.affiliation: Department of Urology, Saitama Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Araki
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Kase
authors.forename: K
authors.initials: K
authors.lastname: Okada
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D000328:Adult; D004298:Dopamine / Q000097:blood*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D010673:Pheochromocytoma / Q000097:blood / Q000150:complications* / Q000556:secondary; D014521:Urethra / Q000503:physiopathology*; D014555:Urination Disorders / Q000209:etiology*; D014563:Urodynamics / Q000502:physiology
chemical_list: D004298:Dopamine