title: [Specific inflammatory processes in collagenosis, degenerative and malignant diseases of the skin of the face and neck during aging].
abstract: 214 skin lesions have been analyzed in the paper and 158 cases of Carcinoma basocellulare, 22 cases of Carcinoma planocellulare and 11 cases of melanoma were registered. Concerning localization it has been established that skin of the face is mostly endangered both for malignant and benign lesions. In 10 cases Keratosis senilis, a benign kind of lesion, was diagnosed, Dermatitis post irradiationem was diagnosed in 8 cases and Lupus erythematodus in 5 cases. By histologic analysis the following can be stated: if the degree of degradation and damage of collagen fibers is high, the intensity of lymphoplasm infiltrate density and intensity of mastocyte cells density is reduced. If the degree of decomposition of collagen fibers is lower, the lymphoplasmocyte infiltrates are denser as in the stroma of the lesion as well in edges and in the surrounding dermis. Changes were primarily found in malignant skin lesions, but they are identical in cases of keratosis senilis as a premalignant lesion. However, concerning nonmalignant lesions, depending on exterior factors, long time influence of noxa, collagen fibers and their degree of degradation have an important role in the cell interaction, and more attention should be paid to exploring decomposition of collagen fibers as components of the local immunobiologic reaction of the organism to lesion formation.
authors.affiliation: Institut medicinskih sluzbi, Medicinski fakultet, Novi Sad.
authors.forename: Z
authors.initials: Z
authors.lastname: Ićurup
authors.forename: N
authors.initials: N
authors.lastname: Vucković
mesh_terms: D005148:Facial Dermatoses / Q000473:pathology; D006801:Humans; D007249:Inflammation; D009333:Neck; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology
vernacular_title: Specificni zapaljenjski procesi kolagenoza, degenerativna i maligna oboljenja koze lica i vrata tokom starenja.