Transient neonatal diabetes and later onset diabetes: a case of inherited insulin resistance.
A 13 year old girl who had had transient neonatal diabetes developed permanent diabetes. She had raised fasting insulin concentrations suggestive of insulin resistance with a suboptimal insulin response to glucose loading. Both her mother and sister had profound insulin resistance; neither had clinical diabetes. This is the first time inherited insulin resistance has been implicated in the pathogenesis of permanent diabetes developing after transient neonatal diabetes.
Shield
J P
JP
Institute of Child Health, Bristol.
Baum
J D
JD
D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000235:genetics*; D010375:Pedigree