title: Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains.
abstract: We have isolated cDNAs from normal human breast tissue and breast tumour cells that encode a protein (pez) with features of a novel non-receptor tyrosine phosphatase possessing N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family. Northern blot analysis indicates that pez is expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta. Fluorescence in situ hybridization has mapped pez to chromosome 1 region q32.2-41. Sequence identity to a characterized polymorphic marker confirms this localization.
authors.affiliation: Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
authors.forename: A L
authors.initials: AL
authors.lastname: Smith
authors.forename: P J
authors.initials: PJ
authors.lastname: Mitchell
authors.forename: J
authors.initials: J
authors.lastname: Shipley
authors.forename: B A
authors.initials: BA
authors.lastname: Gusterson
authors.forename: M V
authors.initials: MV
authors.lastname: Rogers
authors.forename: M R
authors.initials: MR
authors.lastname: Crompton
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D001940:Breast / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism*; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D003001:Cloning, Molecular; D003598:Cytoskeletal Proteins; D017931:DNA Primers; D018076:DNA, Complementary / Q000378:metabolism*; D005260:Female; D015723:Gene Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000096:biosynthesis* / Q000737:chemistry; D016133:Polymerase Chain Reaction; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis* / Q000737:chemistry / Q000502:physiology; D054558:Protein Tyrosine Phosphatases, Non-Receptor; D012333:RNA, Messenger / Q000302:isolation & purification / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured; D000099149:Ezrin
chemical_list: D003598:Cytoskeletal Proteins; D017931:DNA Primers; D018076:DNA, Complementary; D010750:Phosphoproteins; D017027:Protein Tyrosine Phosphatases; D054558:Protein Tyrosine Phosphatases, Non-Receptor; D012333:RNA, Messenger; D000099149:Ezrin; C093261:PTPN14 protein, human