title: [Biochemical and ultrastructural changes in the periodontium during the chronic administration of pro-oxidant xenobiotics].
abstract: Effects of chronic administration of xenobiotics pro-oxidants on the state of periodontal tissues, level of free-radical oxidation of lipids, and antioxidant provision were studied. Diphenin and delagil were found to promote biochemical and morphological changes similar to the manifestations observed in periodontitis. A conclusion is made about an important role of nonenzymatic free-radical oxidation of lipids and biopolymers in the pathogenesis of periodontitis. The principal stages of contribution of autooxidation to the parodontogenesis are presented.
authors.forename: V N
authors.initials: VN
authors.lastname: Bobyrev
authors.forename: E V
authors.initials: EV
authors.lastname: Kovalev
authors.forename: N V
authors.initials: NV
authors.lastname: Rozkolupa
authors.forename: N F
authors.initials: NF
authors.lastname: Eremina
authors.forename: O N
authors.initials: ON
authors.lastname: Voskresenskiĭ
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000494:pharmacology; D002738:Chloroquine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008854:Microscopy, Electron; D010519:Periodontium / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D010672:Phenytoin / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D010672:Phenytoin; C023676:chloroquine diphosphate; D002738:Chloroquine
vernacular_title: Biokhimicheskie i ul'trastrukturnye izmeneniia v parodonte pri khronicheskom vvedenii ksenobiotikov-prooksidantov.