title: Treatment of diarrhea in carcinoid syndrome with ondansetron, tropisetron, and clonidine.
abstract: A 69-yr-old man with known carcinoid syndrome treated with octreotide and interferon-alpha 2b developed diarrhea, with six to eight watery to semiliquid stools per day. Diminished stool frequency and increased stool consistency were obtained by treatment with the 5-hydroxytryptamine-3 receptor antagonists ondansetron and tropisetron. Successful alleviation of the diarrhea was also observed with the alpha 2-receptor agonist clonidine. These observations indicate that these classes of drugs should be evaluated in a controlled trial in patients with carcinoid-associated diarrhea.
authors.affiliation: Department of Medicine, University of Göttingen, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schwörer
authors.forename: H
authors.initials: H
authors.lastname: Münke
authors.forename: F
authors.initials: F
authors.lastname: Stöckmann
authors.forename: G
authors.initials: G
authors.lastname: Ramadori
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D003000:Clonidine / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008303:Malignant Carcinoid Syndrome / Q000188:drug therapy*; D008875:Middle Aged; D017294:Ondansetron / Q000627:therapeutic use*; D000077526:Tropisetron
chemical_list: D000932:Antiemetics; D007211:Indoles; D017294:Ondansetron; D000077526:Tropisetron; D003000:Clonidine