Multiple endocrine neoplasia 2B (MEN 2B)/MEN 3.
Multiple endocrine neoplasia type 2B/3 is characterized by multiple mucosal neuromas, a marfanoid appearance, medullary thyroid carcinoma, pheochromocytoma, gastrointestinal ganglioneuromatosis, and thickened corneal nerves. This rare syndrome is inherited in an autosomal dominant pattern. Early recognition followed by appropriate screening and treatment can be life-saving.
Holloway
K B
KB
Division of Dermatology and Cutaneous Surgery, University of Florida College of Medicine, Gainesville, USA.
Flowers
F P
FP
D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000473:pathology; D002277:Carcinoma / Q000235:genetics / Q000473:pathology; D003315:Cornea / Q000294:innervation; D005729:Ganglioneuroma / Q000235:genetics / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000473:pathology; D006801:Humans; D008382:Marfan Syndrome / Q000473:pathology; D018814:Multiple Endocrine Neoplasia Type 2b / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D009463:Neuroma / Q000235:genetics / Q000473:pathology; D010673:Pheochromocytoma / Q000235:genetics / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology