The effect of indomethacin on cyclosporin A- and its solvent-induced inhibition of endothelium-dependent relaxation and the drug-induced contraction of rabbit isolated arteries.
1. In the isolated rabbit arteries, the effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation were investigated in the absence and presence of indomethacin (10(-5) M), a cyclooxygenase inhibitor. 2. The effect of indomethacin on the drug- and solvent-induced contraction of superior mesenteric artery was also evaluated. 3. The inhibitory effects of cyclosporin and the solvent on endothelium-dependent relaxations were decreased by indomethacin. The direct contractions produced by the drug and the solvent in rabbit mesenteric artery were inhibited by indomethacin.
Yaris
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E
Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Tuncer
M
M
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000502:physiology*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D014677:Pharmaceutical Vehicles; C000515:cremophor EL; D016572:Cyclosporine; D000109:Acetylcholine; D005990:Glycerol; D007213:Indomethacin