Unusually high affinity of Zn(II)-tetradibenzobarrelenooctabutoxy-phthalocyanine for low-density lipoproteins in a tumor-bearing mouse.
An important factor in determining the efficacy of photosensitizing compounds in photodynamic therapy of tumors is the level to which tumors take up the photosensitizers after systemic injection. This parameter seems to be related to the transport modalities of the photosensitizer in the bloodstream. In this work the photosensitizer Zn(II)-tetradibenzobarrelenooctabutoxyphthalocyanine was shown to have an unprecedentedly high association with low-density lipoproteins (71% of the phthalocyanine in the plasma) when delivered in Cremophor micelles to tumor-bearing mice. This was accompanied by a particularly high tumor uptake at 24 h post-injection.
Soncin
M
M
Department of Biology, University of Padova, Italy.
Polo
L
L
Reddi
E
E
Jori
G
G
Rihter
B D
BD
Kenney
M E
ME
Rodgers
M A
MA
D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000378:metabolism; D007211:Indoles / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000378:metabolism*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000378:metabolism* / Q000493:pharmacokinetics
D007211:Indoles; D008077:Lipoproteins, LDL; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C092992:zinc(II)-tetradibenzobarrelenooctabutoxyphthalocyanine