title: Expression of insulin-like growth factor receptor mRNA in rabbit atherosclerotic lesions.
abstract: We have found by 'in situ' hybridization a high level of expression of insulin- like growth factor I receptor (IGF-I R) gene in foam cells of atherosclerotic rabbit aortas. By reaction with either anti- rabbit macrophage (RAM11) or anti smooth muscle cell antibodies we also found that most cells expressing increased amounts of IGF-I R mRNA were of smooth muscle cell origin. Thus, increased IGF-I R mRNA levels might be related to the genesis of the atheroma plaque.
authors.affiliation: Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain.
authors.forename: J I
authors.initials: JI
authors.lastname: Polanco
authors.forename: M T
authors.initials: MT
authors.lastname: Berciano
authors.forename: M
authors.initials: M
authors.lastname: Lafarga
authors.forename: J
authors.initials: J
authors.lastname: León
authors.forename: M
authors.initials: M
authors.lastname: Pocoví
authors.forename: J C
authors.initials: JC
authors.lastname: Rodríguez-Rey
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D017403:In Situ Hybridization; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000648:ultrastructure; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D011817:Rabbits; D017451:Receptors, Somatomedin / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D017451:Receptors, Somatomedin