A microdissection library of the rat renal carcinoma gene region.
Predisposition to hereditary renal carcinoma in the Eker rat involves a mutation of a putative tumor suppressor gene within chromosome band 10q12. We describe the identification of three unique polymorphic sequences in the vicinity of this locus following the microdissection, construction and characterization of a region-specific DNA library for rat chromosome band 10q12.
Bell
D W
DW
Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, PA, USA.
Yeung
R S
RS
Bohlander
S K
SK
Cheng
J Q
JQ
Jin
F
F
Testa
J R
JR
D000818:Animals; D015139:Blotting, Southern; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002874:Chromosome Mapping; D004210:Dissection / Q000379:methods; D015723:Gene Library; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics*; D008846:Micromanipulation; D016133:Polymerase Chain Reaction; D051381:Rats