title: Adrenogenital syndrome caused by an androgen-producing adrenocortical tumor.
abstract: We describe here a typical case of virilizing adrenocortical tumor. A 23-year-old Japanese woman had her male-like musculature, hirsutism, the absence of breast development and marked clitoromegaly. Adrenal androgens were remarkably elevated, with plasma dehydroepiandrosterone sulfate 2,752 micrograms/dl, plasma testosterone 250 ng/dl and urinary 17-ketosteroids 203.4 mg/day. A well-encapsulated tumor approximately 7 cm in diameter was detected in the left adrenal gland by computed tomography, magnetic resonance imaging and arteriography. The tumor was surgically resected and histologically diagnosed as a benign adrenocortical adenoma. The elevated adrenal androgens returned to normal postoperatively with amelioration of her masculinized clinical features.
authors.affiliation: Department of Medicine, Kobe University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Sakuma
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: F
authors.initials: F
authors.lastname: Kanda
authors.forename: K
authors.initials: K
authors.lastname: Hanioka
authors.forename: K
authors.initials: K
authors.lastname: Hisano
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Chihara
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000312:Adrenal Hyperplasia, Congenital / Q000209:etiology* / Q000473:pathology; D000328:Adult; D000728:Androgens / Q000378:metabolism; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography
chemical_list: D000728:Androgens