title: Multisite clinical trials in alcoholism treatment research: organizational, methodological and management issues.
abstract: Multisite clinical trials have two major advantages over single-site studies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population being studied. However, they are more complex to implement than single-site studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite design, management of such studies, and some statistical issues.
authors.affiliation: National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20892-7003.
authors.forename: R K
authors.initials: RK
authors.lastname: Fuller
authors.forename: M E
authors.initials: ME
authors.lastname: Mattson
authors.forename: J P
authors.initials: JP
authors.lastname: Allen
authors.forename: C L
authors.initials: CL
authors.lastname: Randall
authors.forename: R F
authors.initials: RF
authors.lastname: Anton
authors.forename: T F
authors.initials: TF
authors.lastname: Babor
mesh_terms: D000437:Alcoholism / Q000523:psychology / Q000534:rehabilitation*; D002985:Clinical Protocols; D006801:Humans; D015337:Multicenter Studies as Topic / Q000379:methods*; D010043:Outcome and Process Assessment, Health Care; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012106:Research