Changes of the activities of urea cycle enzymes extracted from rat liver after surgical reduction of stomach capacity and after feeding a high-fat diet.
Fourty-two Wistar FL tribe rats were divided into control groups, fed a high-fat diet or subjected to surgical reduction of stomach capacity by 75%. After 60 days of experiment we observed decrease of animal body weight gain, as well as decrease of ornithine transcarbamylase and arginase activity. As indicated by the activity of these enzymes high-fat diet leads to an increase in urea cycle activity probably due to metabolic and hormonal imbalance. The utilisation of carbamoylphosphate for the pyrimidine biosynthesis pathway did not seem to change the ATC-ase activity.
Tarnawski
R
R
Department of Biochemistry, Silesian Medical University, Zabrze, Poland.
Tomasik
A
A
D000818:Animals; D001119:Arginase / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D015391:Gastroplasty; D008099:Liver / Q000201:enzymology*; D008297:Male; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014508:Urea / Q000378:metabolism; D015430:Weight Gain
D004041:Dietary Fats; D014508:Urea; D009954:Ornithine Carbamoyltransferase; D001119:Arginase