[Chromopharmacokinetics and chromopharmacodynamics of drugs].
The review includes results of studies on the influence of biological rhythms in pharmacokinetics and pharmacodynamics of drugs. Rhythmical changes in physiological functions of the organism can change pharmacokinetic parametres. Their values depend on the time of administration. The properties and the number of receptors in the target tissue can also be under influence of time and in this way pharmacodynamic effect can be influenced. The results of chronopharmacological studies can be used in clinical practice and pharmaceutical research.
Kopecká
J
J
Ustav klinické biochemie a diagnostiky, Fakultní nemocnice Hradec Králové.
Palicka
V
V
D000818:Animals; D002940:Circadian Rhythm; D006801:Humans; D010599:Pharmacokinetics
Chronofarmakokinetika a chronofarmakodynamika léciv.