G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.
The utrophin gene is closely related to the dystrophin gene in both sequence and genomic structure. The Duchenne muscular dystrophy (DMD) locus encodes three 14-kb dystrophin transcripts in addition to several smaller isoforms, one of which, Dp116, is specific to peripheral nerve. We describe here the corresponding 5.5-kb mRNA from the utrophin locus. This transcript, designated G-utrophin, is of particular interest because it is specifically expressed in the adult mouse brain and appears to be the predominant utrophin transcript in this tissue. G-utrophin is expressed in brain sites generally different from the regions expressing beta-dystroglycan. During mouse embryogenesis G-utrophin is also seen in the developing sensory ganglia. Our data confirm the close evolutionary relationships between the DMD and utrophin loci; however, the functions for the corresponding proteins probably differ.
Blake
D J
DJ
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
Schofield
J N
JN
Zuellig
R A
RA
Górecki
D C
DC
Phelps
S R
SR
Barnard
E A
EA
Edwards
Y H
YH
Davies
K E
KE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D002478:Cells, Cultured; D016384:Consensus Sequence; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000235:genetics*; D018076:DNA, Complementary; D016189:Dystrophin / Q000235:genetics*; D017950:Ganglia, Sensory / Q000378:metabolism*; D015870:Gene Expression; D017403:In Situ Hybridization; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D009137:Muscular Dystrophy, Animal / Q000235:genetics; D016366:Open Reading Frames; D009928:Organ Specificity; D012333:RNA, Messenger / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D049411:Utrophin
D003598:Cytoskeletal Proteins; D018076:DNA, Complementary; D016189:Dystrophin; D008565:Membrane Proteins; D012333:RNA, Messenger; C483600:Utrn protein, mouse; D049411:Utrophin