title: Structure activity studies on chemically modified homologues of the antibiotic phytotoxic leucinostatin A.
abstract: The synthesis and a conformational study of a number of homologues of the well known antibiotic, phytotoxic leucinostatin A are reported. The circular dichroism of all the compounds are discussed. Some conclusions on the SAR of these compounds are drawn. The influence of the alpha-helical conformation and/or the increased lipophile character on their interesting biological activities is emphasized.
authors.affiliation: Dipartimento de Scienze Farmaceutiche, Università di Ferrara, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Vertuani
authors.forename: M
authors.initials: M
authors.lastname: Boggian
authors.forename: A
authors.initials: A
authors.lastname: Scatturin
authors.forename: M
authors.initials: M
authors.lastname: Ricci
authors.forename: B
authors.initials: B
authors.lastname: Meli Balbocchino
authors.forename: L
authors.initials: L
authors.lastname: Tuttobello
authors.forename: C
authors.initials: C
authors.lastname: Rossi
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D002942:Circular Dichroism; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010455:Peptides; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; C008268:leucinostatin A