Independent correlation between plasma lipoprotein(a) and angiographic coronary artery disease in NIDDM.
OBJECTIVE
To examine the correlation between angiographic coronary artery disease (CAD) and plasma lipoprotein(a) [Lp(a)] concentration in non-insulin-dependent diabetes mellitus (NIDDM).


METHODS
In this cross-sectional study of 36 patients with NIDDM who underwent coronary angiography, CAD was assessed visually using a coronary artery score (CAS), and plasma Lp(a) was measured immunoturbidimetrically.


RESULTS
Lp(a) concentration was significantly higher in patients in the middle and upper tertiles of CASs (> 4) compared with those in the lower tertile (< or = 4); geometric mean 0.30 g/l (95% confidence interval [CI] 0.22-0.40) vs. 0.12 g/l (0.08-0.17, P = 0.002). Lp(a) was significantly and positively correlated with the CAS (R2 23%, P = 0.006), independent of other cardiovascular risk factors, including lipoprotein related variables and glycated hemoglobin.


CONCLUSIONS
Plasma Lp(a) is a strong and independent correlate of the extent of angiographic CAD in symptomatic patients with NIDDM.
Watts
G F
GF
Department of Chemical Pathology, United Medical School, Guy's Hospital, London, U.K.
ap Gwilym
R M
RM
Mazurkiewicz
J
J
Coltart
J
J
D001055:Apolipoproteins B / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
D001055:Apolipoproteins B; D001786:Blood Glucose; D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D014280:Triglycerides