Absorption of (-)-epigallocatechin gallate into rat portal vein.
Following oral administration of (-)-epigallocatechin gallate to rats, the presence of (-)-epigallocatechin gallate was examined in the portal blood. A compound present in the blood was identified as (-)-epigallocatechin gallate by HPLC and mass spectrometry analysis. The results clearly demonstrate that (-)-epigallocatechin gallate is absorbed, at least in part, into rat portal blood.
Okushio
K
K
Food Research Laboratories, Mitsui Norin Co., Ltd., Fujieda-shi, Japan.
Matsumoto
N
N
Suzuki
M
M
Nanjo
F
F
Hara
Y
Y
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D008297:Male; D011169:Portal Vein / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D002392:Catechin; C045651:epigallocatechin gallate