[Relation between age of mice and activity and characteristics of serum alkaline phosphatase].
Characteristics of serum alkaline phosphatase (SAP) were investigated in five strains of young and old mice (C57BL/6, BALB/c, C3H/Bi, MRL/Ipr, Ipr, NZB). SAP activity was measured and SAP kinetics was automatically measured by a spectrophotometer. The heat stability and the inhibitor, beta-bromotetramisole, sensitivity of SAP were also determined. Activity of SAP in old mice was significantly lower compared to young mice of the same strain (P < 0.01). SAP of young mice was more heat labile and was more sensitive to inhibitor as compared to SAP of old mice.
Wang
L
L
Institute of Basic Medical Sciences, CAMS, Beijing.
Shao
R
R
Good
R A
RA
D000375:Aging / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D013773:Tetramisole / Q000031:analogs & derivatives / Q000494:pharmacology
C006226:4-bromotetramisole; D013773:Tetramisole; D000469:Alkaline Phosphatase