[Effect of aflatoxin B1 on monooxygenase activity in liver microsomes exposed to cytochrome P-450].
Effect of aflatoxin B1 (AFB1) on microsomal ethoxycumarindeethylase (ECDE) and amidopyrindemethylase (APDM) activities in liver of Wistar rats treated with inductors of different forms of cytochrome P-450 (P-450) 3-methylcholanthrene (3-MC) and phenobarbital (PB) were studied. AFB1 caused strong inhibition of ECDE activity, induced by 3-MC. 150 for AFB1 was equal 3.2 10-5. In the same time AFB1 did not effect on basal and PB induced ECDE and APDM activities. Participation of MC induced forms of cytochrome P-450 (P-448) in activation of AFB1 is supposed.
Astashkin
E I
EI
Prikhodko
A Z
AZ
D015660:7-Alkoxycoumarin O-Dealkylase / Q000187:drug effects* / Q000378:metabolism; D016604:Aflatoxin B1 / Q000378:metabolism / Q000494:pharmacology*; D000633:Aminopyrine N-Demethylase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D008748:Methylcholanthrene / Q000378:metabolism / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D010634:Phenobarbital / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D016604:Aflatoxin B1; D015660:7-Alkoxycoumarin O-Dealkylase; D000633:Aminopyrine N-Demethylase; D010634:Phenobarbital
Deĭstvie aflatoksina B1 na aktivnost monooksigenaz mikrosom pecheni krys, sviazannuiu s raznymi formami tsitokhroma P-450.