[The protective effects of cilazapril of chronic hypoxic pulmonary hypertension and hypoxemia in rats].
This study attempted to research the protective effects of cilazapril, a new ACE inhibitor, on chronic hypoxic pulmonary hypertension and hypoxemia in rats. The mean pulmonary arterial pressure (mPAP) of the rats after hypoxia and injection with 1% Fecl3 via the tail veins for 4 weeks increased significantly but its PaO2 decreased separately. Cilazapril effectively protected mPAP increase and PaO2 decrease in rats treated with Cilazapril (0.5 mg/d) by suppressing the lung injury of TNF and oxygen free radical.
Zhang
D M
DM
General Hospital of Guangzhou Command of PLA.
Zou
X Y
XY
Xin
D L
DL
D000818:Animals; D017315:Cilazapril / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000517:prevention & control*; D000860:Hypoxia / Q000150:complications* / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D017315:Cilazapril