Croton zehntneri: possible central nervous system effects of the essential oil in rodents.
The effects of essential oil of Croton zehntneri (Euphorbiaceae), orally administered were studied on behavioral parameters using rats and mice. The oil suspension did not modify pentobarbital induced-hypnosis, stereotypic behavior, catalepsy and amphetamine-induced hypermotility. The open-field behaviors were decreased and the minimal convulsant dose of pentylenetetrazole was increased.
Batatinha
M J
MJ
Department of Pathology, Faculty of Veterinary Medicine and Zootechnique, University of São Paulo, Brazil.
de Souza-Spinosa
H
H
Bernardi
M M
MM
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001938:Brazil; D002375:Catalepsy / Q000139:chemically induced; D003436:Croton Oil / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D000927:Anticonvulsants; D003436:Croton Oil; D000661:Amphetamine; D010424:Pentobarbital; D010433:Pentylenetetrazole