title: Genetic and molecular ecotoxicology: a research framework.
abstract: Participants at the Napa Conference on Genetic and Molecular Ecotoxicology assessed the status of this field in light of heightened concerns about the genetic effects of exposure to hazardous substances and recent advancements in our capabilities to measure those effects. We present here a synthesis of the ideas discussed throughout the conference, including definitions of important concepts in the field and critical research needs and opportunities. While there were many opinions expressed on these topics, there was general agreement that there are substantive new opportunities to improve the impact of genetic and molecular ecotoxicology on prediction of sublethal effects of exposure to hazardous substances. Future studies should emphasize integration of genetic ecotoxicology, ecological genetics, and molecular biology and should be directed toward improving our understanding of the ecological implications of genotoxic responses. Ecological implications may be assessed at either the population or ecosystem level; however, a population-level focus may be most pragmatic. Recent technical advancements in measuring genetic and molecular responses to toxicant exposure will spur rapid progress. These new techniques have considerable promise for increasing our understanding of both mechanisms of toxicity on genes or gene products and the relevance of detrimental effects to individual fitness.
authors.affiliation: Lawrence Berkeley Laboratory, Berkeley, CA 94708, USA.
authors.forename: S
authors.initials: S
authors.lastname: Anderson
authors.forename: W
authors.initials: W
authors.lastname: Sadinski
authors.forename: L
authors.initials: L
authors.lastname: Shugart
authors.forename: P
authors.initials: P
authors.lastname: Brussard
authors.forename: M
authors.initials: M
authors.lastname: Depledge
authors.forename: T
authors.initials: T
authors.lastname: Ford
authors.forename: J
authors.initials: J
authors.lastname: Hose
authors.forename: J
authors.initials: J
authors.lastname: Stegeman
authors.forename: W
authors.initials: W
authors.lastname: Suk
authors.forename: I
authors.initials: I
authors.lastname: Wirgin
mesh_terms: D000818:Animals; D004463:Ecology; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000009:adverse effects; D005544:Forecasting; D015386:Hazardous Substances / Q000009:adverse effects; D006801:Humans; D008967:Molecular Biology / Q000639:trends*; D009153:Mutagens / Q000009:adverse effects; D012106:Research / Q000639:trends; D014116:Toxicology / Q000639:trends*
chemical_list: D004785:Environmental Pollutants; D015386:Hazardous Substances; D009153:Mutagens