Simian immunodeficiency virus (SIV)-specific CTL in cerebrospinal fluid and brains of SIV-infected rhesus macaques.
Simian immunodeficiency virus (SIV)-specific CD8+ CTL were isolated from blood, cerebrospinal fluid, and brains of rhesus macaques infected i.v. with SIV. CTL were found as early as 1 wk postinfection and their appearance correlated with a decrease of viral Ag (p27) found in the blood. CTL isolated from cerebrospinal fluid and/or brain often recognized different viral proteins than CTL isolated from blood, suggesting either a unique migratory pattern to the central nervous system or a difference in activation/retention of lymphocytes in these compartments.
von Herrath
M
M
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA.
Oldstone
M B
MB
Fox
H S
HS
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000166:cytology / Q000276:immunology*; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D008221:Lymphoid Tissue / Q000166:cytology; D008253:Macaca mulatta; D008297:Male; D008969:Molecular Sequence Data; D016097:Simian Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*