title: Capsid protein gene sequence of feline calicivirus isolates 255 and LLK: further evidence for capsid protein configuration among feline caliciviruses.
abstract: The capsid protein gene sequences are reported for two feline calicivirus (FCV) isolates, one a highly virulent isolate associated with respiratory disease, designated 255, and an isolate associated with neuromuscular disorders, designated LLK. Both capsid protein sequences conform to a previously described hypothesis wherein FCV capsid proteins may be divided into six regions based on sequence similarity among isolates. Region A corresponds to the amino-terminal area of the protein that is theoretically cleaved to produce the functional species. With a large area of sequence identity among isolates, region B contains a potential myristilated glycine and a putative ATP/GTP binding site. Region C is a short hypervariable sequence of unknown function followed by another conserved area designated region D. The E region is an area of extensive amino acid sequence hypervariability that presumably contains the antigenic determinants of the capsid protein. Region F contains the highly conserved carboxy-terminal portion of the protein.
authors.affiliation: Southeast Poultry Research Laboratory, U.S.D.A., Athens, Georgia 30605, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Seal
authors.forename: J D
authors.initials: JD
authors.lastname: Neill
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017927:Calicivirus, Feline / Q000235:genetics*; D002213:Capsid / Q000737:chemistry / Q000235:genetics*; D002415:Cats; D004279:DNA, Viral; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral