[Efficacy of magnesium in a case of neonatal pulmonary hypertension refractory to the usual therapies].
We describe a premature baby with X pentasomy, having a severe pulmonary hypertension secondary to perinatal asphyxia and hyaline membrane disease which appeared to be refractory to conventional treatments (hyperventilation, tolazoline, prostacyclin). Oxygenation and pulmonary hypertension rapidly improved after starting magnesium sulphate infusion (loading dose: 20 mg/kg e.v. of elementary Mg, followed by continuous infusion of 2-4 mg/kg/hr during 6 days). The therapy was associated with hypermagnesemia (5-7 mg/100 ml) and transitory side effects (hypocalcemia, muscular and bladder paresis, bradycardia without hemodynamic decompensation). We suggest that magnesium therapy might be considered in newborns with severe and persistent pulmonary hypertension.
Colonna
F
F
Centro di Neonatologia, Istituto per l'Infanzia IRCCS, Burlo Garofolo, Trieste.
Giorgi
R
R
Ciana
G
G
Benettoni
A
A
D001238:Asphyxia Neonatorum / Q000150:complications; D011464:Epoprostenol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006819:Hyaline Membrane Disease / Q000150:complications; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008274:Magnesium / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D014043:Tolazoline / Q000627:therapeutic use
D014043:Tolazoline; D011464:Epoprostenol; D008274:Magnesium
Efficacia del magnesio in un caso di ipertensione polmonare neonatale resistente alle comuni terapie.