title: Magnetization transfer imaging of periventricular hyperintense white matter in the elderly.
abstract: OBJECTIVE
  To characterize with magnetization transfer imaging the pathologic substrate of the nonspecific periventricular hyperintense white matter changes seen on T2-weighted images of elderly patients.
  
  
  METHODS
  Twenty-one elderly patients with periventricular hyperintense white matter on T2-weighted MR images and eleven control subjects were studied using MT technique. Magnetization transfer ratios (MTRs) were calculated for the periventricular hyperintense white matter and normal-appearing white matter. These MTRs were correlated with histopathologic changes that have previously been reported as well as with established MTRs for other lesions.
  
  
  RESULTS
  The MTRs (mean, 35.2; SD, 1.2) in the periventricular hyperintense white matter are lower than those in the normal white matter of the patient (mean, 40.8; SD, 1.4) and control (mean, 41.3; SD, 1.8) groups. These MTRs are much higher than those of demyelinating lesions but are similar to those of experimental lesions with just edema.
  
  
  CONCLUSIONS
  Because MTR may reflect to some extent histopathologic changes and thus provide more specificity than conventional pulse sequences, the main pathologic substrate accounting for the lower MTR in periventricular hyperintense white matter is probably the increased water content in reactive astrocytes.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: K T
authors.initials: KT
authors.lastname: Wong
authors.forename: R I
authors.initials: RI
authors.lastname: Grossman
authors.forename: J M
authors.initials: JM
authors.lastname: Boorstein
authors.forename: F J
authors.initials: FJ
authors.lastname: Lexa
authors.forename: J C
authors.initials: JC
authors.lastname: McGowan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values