Recombinant haplotype bearing the lymphopenia gene of the BB rat.
The development of insulin-dependent diabetes mellitus in the BB rat requires the presence of the class II major histocompatibility complex alleles of the RT1u haplotype and a T cell lymphopenia. The lymphopenia gene (lyp) behaves as an autosomal recessive trait that co-segregates with markers of rat chromosome 4. The current study examines two congenic and four recombinant inbred rat strains derived from BB and Buffalo rat strains using markers for simple-sequence length polymorphisms to confirm the linkage of the lymphopenia gene to chromosome 4. In two of these lines the lymphopenia associates with a recombinant haplotype that is BB-like at the D4Mit6 marker and Buffalo-like at D4Mit7 (neuropeptide Y locus) thus placing the lyp locus between these two closely linked markers.
Fuks
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McGill Cancer Centre, Montreal, Que., Canada.
Colle
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Guttmann
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D000818:Animals; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D008231:Lymphopenia / Q000235:genetics*; D051381:Rats; D011913:Rats, Inbred BB; D011915:Rats, Inbred BUF
D005819:Genetic Markers