title: Frequency and explanation of false negative diagnosis of aortic dissection by aortography and transesophageal echocardiography.
abstract: OBJECTIVE
  This study was designed to define the frequency and explanation of false negative diagnosis of aortic dissection by aortography and transesophageal echocardiography.
  
  
  BACKGROUND
  Aortography and transesophageal echocardiography have been widely utilized to diagnose aortic dissection. Previous reports have not fully addressed the reasons why these studies yield false negative results in a large number of patients with aortic dissection.
  
  
  METHODS
  Sixty-five consecutive patients with aortic dissection underwent aortography and transesophageal echocardiography. Diagnosis of aortic dissection was confirmed at operation or by computed tomography in all patients.
  
  
  RESULTS
  Biplane transesophageal echocardiograms yielded false negative results in two patients (sensitivity 97% [63 of 65]). Both patients had well localized DeBakey type II aortic dissection. The diagnosis was probably missed because of image interference from the air-filled trachea and mainstem bronchi. In both patients, the dissection was readily identified by aortography. Aortograms yielded false negative results in 15 patients (sensitivity 77% [50 of 65]); the aortic dissection was type I in 7 patients, type II in 1 and type III in 7. The dissection in all 15 patients was readily identified by transesophageal echocardiography. The missed diagnosis was probably due to a completely thrombosed false lumen or intramural hematoma with noncommunicating dissection in 13 patients and to a large ascending aortic aneurysm with nearly equal flow on both sides of the intimal flap in 2. In no patient was the diagnosis missed by both aortography and transesophageal echocardiography.
  
  
  CONCLUSIONS
  Transesophageal echocardiography is an excellent screening tool for aortic dissection. However, it may miss small type II aortic dissections localized to the upper portion of the ascending aorta because of image interference from the air-filled trachea. An intramural hematoma cannot be easily visualized by aortography, and this lesion is the principal reason for false negative aortographic findings.
authors.affiliation: Department of Internal Medicine, Loma Linda University, California, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Bansal
authors.forename: K
authors.initials: K
authors.lastname: Chandrasekaran
authors.forename: K
authors.initials: K
authors.lastname: Ayala
authors.forename: D C
authors.initials: DC
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000175:diagnosis*; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis*; D001027:Aortography; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D005188:False Negative Reactions; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis; D006406:Hematoma / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed