title: Reciprocal IL-1 beta gene expression in medial and lateral hypothalamic areas in SART-stressed mice.
abstract: Specific alteration of rhythm of temperature (SART) stress has been found to induce thymic atrophy via activation of the hypothalamus-pituitary-adrenal (HPA) axis. We demonstrate here that SART stress induces increment of IL-1 beta mRNA levels in the medial hypothalamic area (MHA) and decrement of IL-1 beta mRNA levels in the lateral hypothalamic area (LHA). The altered levels of IL-1 beta expression in these loci return to those of non-stressed mice upon cessation of the stress. These data imply that the reciprocal wave of SART stress-induced IL-1 beta gene expression in MHA and LHA may contribute to activation of the HPA axis and the resulting immunological dysfunction.
authors.affiliation: Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tagoh
authors.forename: H
authors.initials: H
authors.lastname: Nishijo
authors.forename: T
authors.initials: T
authors.lastname: Uwano
authors.forename: H
authors.initials: H
authors.lastname: Kishi
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: A
authors.initials: A
authors.lastname: Muraguchi
mesh_terms: D000818:Animals; D005260:Female; D015870:Gene Expression; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007031:Hypothalamus / Q000502:physiology*; D007375:Interleukin-1 / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D013312:Stress, Physiological / Q000235:genetics* / Q000378:metabolism; D013696:Temperature
chemical_list: D007375:Interleukin-1; D012333:RNA, Messenger