title: Exercise-induced hypertension in the arms due to impaired arterial reactivity after successful coarctation resection.
abstract: Exercise-induced hypertension of the arms is a well-known late complication after coarctation repair. Residual narrowing at the anastomosis site as well as abnormalities of the precoarctation arterial system may be the cause of this problem. Blood pressure response to exercise and flow-mediated arterial dilatation of the arms and legs were studied in 29 young adults after successful coarctectomy in childhood and compared with 13 control subjects. Peak exercise systolic blood pressure was significantly higher in patients than in control subjects: 238 versus 199 mm Hg (p = 0.007). Both groups had a positive systolic arm-leg gradient during exercise: 59 versus 37 mm Hg (p = 0.05). Flow-mediated dilatation of the brachial artery was significantly reduced in patients compared with that in control subjects: 4.2% (range 0% to 9.4%) versus 9.4% (range 3.7% to 16%) (p < 0.0001). Flow-mediated dilatation of the femoral artery was similar in both groups. Dilatation of the brachial artery was inversely correlated to peak exercise systolic pressure in the study patients (r = -0.427, p = 0.02). A positive arm-leg exercise gradient partly represents physiologic circulatory adaptation to ergometry and is therefore not appropriate for evaluation of residual narrowing. Exercise-induced hypertension of the arms late after coarctation repair is caused by impaired arterial reactivity, which results from structural or functional abnormality, or both.
authors.affiliation: University Children's Hospital of Basel, Department of Cardiology, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Guenthard
authors.forename: F
authors.initials: F
authors.lastname: Wyler
mesh_terms: D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical / Q000009:adverse effects; D001017:Aortic Coarctation / Q000503:physiopathology / Q000601:surgery*; D001132:Arm / Q000098:blood supply*; D001794:Blood Pressure / Q000502:physiology; D001916:Brachial Artery / Q000503:physiopathology*; D016022:Case-Control Studies; D003251:Constriction, Pathologic / Q000209:etiology; D016552:Ergometry; D005080:Exercise Test; D005263:Femoral Artery / Q000503:physiopathology; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D005082:Physical Exertion / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D013599:Systole; D014664:Vasodilation / Q000502:physiology; D014666:Vasomotor System / Q000503:physiopathology*