The porphyrias and hepatocellular carcinoma.
Hepatocellular carcinoma probably represents the final step of the effects of the various precipitating agents for porphyria cutanea tarda, such as alcohol, drugs, hormones, and hepatitis C infection. Risk factors associated with its development include male gender, age over 50 years, liver fibrosis or cirrhosis, and a long history (over 10 years) of symptomatic porphyria cutanea tarda.
Lim
H W
HW
Department of Veternas Affairs Medical Center, New York, New York, USA.
Mascaro
J M
JM
D000328:Adult; D000367:Age Factors; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017119:Porphyria Cutanea Tarda / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D012307:Risk Factors; D012737:Sex Factors; D014575:Uroporphyrinogen Decarboxylase / Q000172:deficiency
D014575:Uroporphyrinogen Decarboxylase