Pleomorphic xanthoastrocytoma with a gangliomatous component: an immunohistochemical and ultrastructural study.
We report a case of a 24-year-old woman with left temporal pleomorphic xanthoastrocytoma (PXA) with atypical neuronal cells. Many neoplastic cells, otherwise typical of PXA, expressed glial fibrillary acidic protein, while neuronal cells with marked atypia were immunopositive for synaptophysin and neurofilament protein. This report supports a notion that PXA, like other astrocytic tumors, may have its gangliogliomatous counterpart.
Kordek
R
R
Department of Pathology, Medical University of Lódź, Poland.
Biernat
W
W
Sapieja
W
W
Alwasiak
J
J
Liberski
P P
PP
D000328:Adult; D001254:Astrocytoma / Q000378:metabolism* / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D018303:Ganglioglioma / Q000378:metabolism* / Q000648:ultrastructure; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016900:Neurofilament Proteins / Q000378:metabolism; D009457:Neuroglia / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D016708:Synaptophysin / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D016708:Synaptophysin