Trans-splicing and polycistronic transcription in Caenorhabditis elegans.
Caenorhabditis elegans engages in three distinct versions of nuclear pre-mRNA splicing: cis-splicing of introns and two kinds of trans-splicing that result in the addition of two different spliced leaders onto mRNAs. One leader (SL1) is used near the 5' ends of pre-mRNAs while the other (SL2) is used at internal trans-splice sites of polycistronic pre-mRNAs. Here, I consider how these three types of splicing event are faithfully carried out.
Blumenthal
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Department of Biology, Indiana University, Bloomington 47405, USA.
D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000235:genetics*; D005796:Genes; D009876:Operon; D012326:RNA Splicing; D014158:Transcription, Genetic