title: Distribution of cisplatin in perilymph and cerebrospinal fluid after intravenous administration in the guinea pig.
abstract: The concentration of free cisplatin was followed in plasma, scala tympani perilymph and cerebrospinal fluid (CSF) after an intravenous injection (12.5 mg/kg) in guinea pigs. Liquid chromatography with postcolumn derivatization was used for quantitative determination of the drug. The distribution of cisplatin to CSF was fast; at 10 min after drug administration the concentration was 7 micrograms/ml and the CSF:plasma ratio was 0.37. Cisplatin seems to distribute more slowly to the perilymphatic compartment. The highest concentration measured was 4 micrograms/ml at 20 min after the injection, and the perilymph:plasma ratio was 0.40 at that time. The concentration-time curves generated for cisplatin in perilymph and CSF were similar. No accumulation in the perilymphatic compartment or CSF was observed.
authors.affiliation: Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Laurell
authors.forename: A
authors.initials: A
authors.lastname: Andersson
authors.forename: B
authors.initials: B
authors.lastname: Engström
authors.forename: H
authors.initials: H
authors.lastname: Ehrsson
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid; D002945:Cisplatin / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D006168:Guinea Pigs; D007275:Injections, Intravenous; D010498:Perilymph / Q000378:metabolism*; D012533:Scala Tympani; D014018:Tissue Distribution
chemical_list: D002945:Cisplatin