Are infantile myofibromatosis, congenital fibrosarcoma and congenital haemangiopericytoma histogenetically related?
Infantile myofibromatosis, congenital fibrosarcoma and congenital/infantile haemangiopericytoma are generally considered distinct entities. Overlapping microscopic features between infantile myofibromatosis and congenital fibrosarcoma, and between infantile myofibromatosis and congenital/infantile haemangiopericytoma, however, have been noted, but not formally reported. This report concerns six neonatal tumours, each exhibiting more than one of the above patterns, supporting a histogenetic relationship among these entities. Immunohistochemistry for smooth muscle actin was found to be useful in the diagnosis of congenital/infantile haemangiopericytoma, and also served to support a histogenetic relationship with the other two entities under consideration.
Variend
S
S
Department of Pathology, University Hospital, Utrecht, The Netherlands.
Bax
N M
NM
van Gorp
J
J
D000199:Actins / Q000032:analysis; D005260:Female; D005354:Fibrosarcoma / Q000737:chemistry / Q000151:congenital / Q000473:pathology*; D006393:Hemangiopericytoma / Q000737:chemistry / Q000151:congenital / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018224:Myofibromatosis / Q000151:congenital / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D000199:Actins; D014746:Vimentin