title: [Optic neuropathy in systemic lupus erythematosus (SLE)--analysis of 54 cases including our case].
abstract: A 46-year old woman with systemic lupus erythematosus (SLE) who had been treated with oral administration of prednisolone (7.5 mg/5 mg on alternate days) at our outpatient clinic suddenly developed a loss of visual acuity, visual field defect, and photophobia on Dec. 15th, 1993. When she was admitted three days later, she was diagnosed as having optic neuropathy, and immediate treatment with methylprednisolone (1 g/day for three days) followed by prednisolone (50 mg/day) resulted in complete disappearance of the above symptoms by Feb. 9th, 1994. As far as we know, fifty-three cases of SLE with optic neuropathy have been reported previously. The result of analysis of the 54 cases including our case indicates that rapid diagnosis and corticosteroid treatment in an early phase of optic neuropathy leads to significant improvement.
authors.affiliation: First Department of Internal Medicine, Yokohama City University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Igarashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: K
authors.initials: K
authors.lastname: Motoji
authors.forename: F
authors.initials: F
authors.lastname: Takeshita
authors.forename: S
authors.initials: S
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Sumino
authors.forename: T
authors.initials: T
authors.lastname: Soga
authors.forename: A
authors.initials: A
authors.lastname: Shirai
authors.forename: S
authors.initials: S
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Okubo
mesh_terms: D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage
chemical_list: D011239:Prednisolone; D008775:Methylprednisolone