title: Nontoxic intravitreal dose of ofloxacin for rabbit retina.
abstract: We studied the nontoxic intravitreal concentration of ofloxacin, a new quinolone antibacterial agent, by evaluating its effects on in vitro and in vivo electroretinograms (ERGs) in albino and pigmented rabbits. After perfusion with a 36 micrograms/ml solution of ofloxacin, the in vitro ERG remained unchanged. The in vivo ERG and the visually evoked potential remained unchanged 4 weeks after vitrectomy with 50 micrograms/ml ofloxacin, and the retina was within normal limits both ophthalmoscopically and histologically. Therefore, the retinal toxicity of ofloxacin is low and within safe limits at clinical dosage.
authors.affiliation: Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Mochizuki
authors.forename: M
authors.initials: M
authors.lastname: Torisaki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Komatsu
authors.forename: T
authors.initials: T
authors.lastname: Tanahashi
mesh_terms: D000818:Animals; D004596:Electroretinography; D009877:Endophthalmitis / Q000188:drug therapy; D005074:Evoked Potentials, Visual / Q000502:physiology; D007267:Injections; D015242:Ofloxacin / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D014821:Vitrectomy; D014822:Vitreous Body
chemical_list: D015242:Ofloxacin