[Hemocoagulation and hemorheology in heart failure and the possible effects of glycosaminoglycans].
Chronic congestive heart failure is one of the risk groups of acquired hypercoagulant and hyperviscous state. In a group of patients with medium and severe cardiac failure the administration of sulodexide led to an increased activation of the fibrinolytic potential--a drop of PAI-1 and fibrinogen, to an increased activation of anticoagulatory potential--an increase of AT III and reduced plasma viscosity. Global coagulation and biochemical screening parameters were not affected by treatment. Administration of the preparation did not exert important undesirable effects and was well tolerated.
Spinar
J
J
II. interní klinika, FN Brno.
Novotný
J
J
Mayer
J
J
Vítovec
J
J
Spinarová
L
L
D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood
D006025:Glycosaminoglycans; D017395:Plasminogen Activator Inhibitor 1; C007858:glucuronyl glucosamine glycan sulfate; D000990:Antithrombin III; D005340:Fibrinogen
Hemokoagulacní a hemoreologické pomĕry u srdecního selhání a moznosti jejich ovlivnĕní glykosaminoglykany.