The clinical use of antithrombin concentrate in septicaemia.
To date no single agent has emerged as the treatment of choice for the management of septic shock and it is becoming increasingly clear that in future it will prove necessary to combine treatments to provide the optimum therapy. One group of agents that should theoretically prove beneficial in sepsis are the protease inhibitors, antithrombin being the one most widely investigated to date. This article discusses the evidence supporting its use in the treatment of septicaemia.
Harper
P L
PL
West Suffolk Hospital.
D000991:Antithrombins / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004211:Disseminated Intravascular Coagulation / Q000517:prevention & control; D004353:Drug Evaluation, Preclinical; D006801:Humans; D018805:Sepsis / Q000188:drug therapy*
D000991:Antithrombins