title: Novel avidin and streptavidin binding sequences found in synthetic peptide libraries.
abstract: Synthetic resin-bound peptide libraries made of protein L-amino acids have been synthesized. During screening of the libraries, peptides that bind to avidin have been identified containing a novel motif with two histidines separated by one residue. A sub-library was synthesized and screened, and new critical residues appeared surrounding the two histidines. Additionally peptide libraries made of D-amino acids have been screened with avidin and streptavidin and novel motifs have been found.
authors.affiliation: Chemistry Department Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Ostergaard
authors.forename: P H
authors.initials: PH
authors.lastname: Hansen
authors.forename: M
authors.initials: M
authors.lastname: Olsen
authors.forename: A
authors.initials: A
authors.lastname: Holm
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001360:Avidin / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000378:metabolism*; D019809:Streptavidin
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D009842:Oligopeptides; D001360:Avidin; D019809:Streptavidin