title: Deformity incidence in leprosy patients treated with multidrug therapy.
abstract: The records of 2,285 (2,007 paucibacillary (PB) and 278 multibacillary (MB)) cases of leprosy which were declared as released from treatment (RFT) after multidrug therapy (MDT) and under surveillance as per the National Leprosy Eradication Programme (NLEP) guidelines in the rural field practice area of Central Leprosy Teaching & Research Institute (CLTRI), Chengalpattu, between September 1986 and September 1993 were analyzed for collecting data on the incidence of deformity. Of the 2,285 cases 2,053 (1,947 PB and 106 MB) did not have deformity at the commencement of treatment. Three MB cases and one PB case out of the 2,053 developed deformity (all grade II) during the course of treatment. No patient developed deformity during surveillance. Thus the deformity incidence in the population of patients was 0.681 per 1000 person-years of observation. Age, sex, type of disease, prior dapsone monotherapy and nerve involvement at the commencement of treatment appear to influence the deformity incidence. The risk of development of deformity in patients treated with MDT appear to be very low and analysis of larger data sets is suggested to corroborate the above findings as the information would be useful for planning prevention and management of deformity services.
authors.affiliation: Central Leprosy Teaching and Research Institute, Chengalpattu.
authors.forename: P S
authors.initials: PS
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: Subramanian
authors.forename: G
authors.initials: G
authors.lastname: Subramanian
mesh_terms: D000328:Adult; D002648:Child; D003622:Dapsone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007918:Leprosy / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D018570:Risk Assessment
chemical_list: D003622:Dapsone