title: [Clinical significance of platelet volume indices estimated by automated blood cell analyzer].
abstract: Clinical significance of platelet volume indices (Platelet distribution width: PDW, Mean platelet volume: MPV, Platelet large cell ratio: P-LCR) estimated by automated blood cell analyzer (Sysmex NE-8000) was studied in 29 ITP cases and 17 cases with platelet hypoproduction which diagnosis was established by platelet kinetic study, megakaryocyte counts and the amount of platelet-associated IgG. These indices were not obtained by analyzer in 48% of 23 cases with platelet count less than 50 x 10(9)/l and 23% of 31 cases with platelet counts ranged in 50-100 x 10(9)/l. The coefficient of variation (CV) of PDW, MPV and P-LCR estimated 5 times in samples with platelet count more than 100 x 10(9)/l was 2%, 1% and 2.3%, respectively. In samples with platelet count less than 50 x 10(9)/l, CV of each index increased 3 times or more. Only four out of 22 ITP cases with platelet count less than 100 x 10(9)/l showed increased platelet volume and remaining 18 cases showed normal volume. In 12 cases with platelet hypoproduction, 3 cases showed increase of platelet volume and one case showed decrease of volume. Significant correlation was observed in between PDW and platelet survival time (r = -0.41, p < 0.05) and in between PDW and platelet turnover rate (r = 0.38, p < 0.05) in 29 ITP cases. Although the various changes of platelet volume indices during recovery phase after chemotherapy were observed in cases of acute leukemia or malignant lymphoma, these one were not a characteristic change in recovery phase of platelet under-production but rather different in each individual.
authors.affiliation: Department of Hematological Laboratory, Toranomon Hospital, Tokyo.
authors.forename: M
authors.initials: M
authors.lastname: Ogura
authors.forename: M
authors.initials: M
authors.lastname: Yasuno
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Tsukada
mesh_terms: D001792:Blood Platelets / Q000166:cytology*; D006405:Hematology / Q000295:instrumentation; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D015203:Reproducibility of Results; D013921:Thrombocytopenia / Q000097:blood