title: [Thrombolytic therapy of acute myocardial infarct in advanced age (based on 2 case reports)].
abstract: The introduction of thrombolysis has reduced the mortality of acute myocardial infarction (MI) by 25%. Large-scale studies have revealed that especially patients over 65 benefit from this therapy. Nevertheless, many centers apply an age limit for thrombolytic therapy due to the higher risk of stroke or bleeding in elderly patients. In 1993 181 patients suffering from acute MI were admitted to the intensive care unit of the University Clinic of Internal Medicine, Graz, and 54 (29.4%) of them were treated with fibrinolytic drugs. In this paper we report on the successful thrombolytic management of acute MI in two male patients (87 and 88 years old) who were treated with 100 mg recombinant tissue-type plasminogen activator complex. As a sign of successful reperfusion a rapid increase in plasma creatinine kinase levels and fast amelioration of the ischemia-related ECG changes were observed. In the follow-up examination after four months the first patients showed only minimal exertional dyspnea and was otherwise well. The second patient died one month after MI following a laparotomy for ileus. We draw the conclusion that patients of advanced age also benefit from thrombolytic treatment of acute myocardial infarction, but the indications and contraindications have to be carefully observed.
authors.affiliation: Abteilung für Kardiologie, Medizinische Klinik der Karl-Franzens-Universität Graz.
authors.forename: R
authors.initials: R
authors.lastname: Zweiker
authors.forename: B
authors.initials: B
authors.lastname: Eber
authors.forename: P
authors.initials: P
authors.lastname: Kaufmann
authors.forename: M
authors.initials: M
authors.lastname: Schumacher
authors.forename: F M
authors.initials: FM
authors.lastname: Fruhwald
authors.forename: R
authors.initials: R
authors.lastname: Pokan
authors.forename: W
authors.initials: W
authors.lastname: Klein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D011994:Recombinant Proteins / Q000627:therapeutic use; D015996:Survival Rate; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D007527:Isoenzymes; D011994:Recombinant Proteins; D003402:Creatine Kinase; D010959:Tissue Plasminogen Activator
vernacular_title: Thrombolytische Therapie des akuten Myokardinfarktes im hohen Alter (anhand von 2 Fallberichten).