[Liquid crystals and liquid crystal dispersions of DNA-daunomycin complexes].
The X-ray and optical properties as well as the textures of liquid crystals formed of DNA molecules bound in complex with an anthracycline antibiotic daunomycin were investigated. It was shown that DNA.daunomycin complexes, depending on the extent of alteration of the DNA secondary structure by daunomycin, could yield two types of cholesterics differing in the direction of their spatial twisting as well as nematics. Liquid-crystalline dispersions of DNA.daunomycin complexes have CD spectra with "mirror" bands depending on daunomycin concentration. "Testing" of the orientation of daunomycin molecules on the DNA in liquid-crystalline particles suggested two types of binding.
Evdokimov
Iu M
IuM
Salianov
V I
VI
Skuridin
S G
SG
Badaev
N S
NS
D000818:Animals; D002645:Chickens; D002942:Circular Dichroism; D003460:Crystallization; D004247:DNA / Q000737:chemistry*; D003630:Daunorubicin / Q000737:chemistry*; D009690:Nucleic Acid Conformation
D004247:DNA; D003630:Daunorubicin
Zhidkie kristally i zhidkokristallicheskie dispersii kompleksov DNK-daunomitsin.