title: Binding of pesticides to alpha, mu and pi class glutathione transferase.
abstract: The binding of fluorodifen, fenarimol, acifluorfen, 2,4-DES, methyl parathion, paraquat and pyrazophos by alpha, mu and pi class glutathione transferases (GST) was determined by the 2-p-toluidinylnaphthalene-6-sulphonate (TNS) binding fluorescence inhibition technique. Although all the 3 GST classes appear to be capable of binding the pesticides investigated, mu class exhibited somewhat higher affinity than the alpha and pi classes.
authors.affiliation: Istituto di Scienze Biochimiche, Università G. D'Annunzio, Chieti, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Di Ilio
authors.forename: P
authors.initials: P
authors.lastname: Sacchetta
authors.forename: V
authors.initials: V
authors.lastname: Iannarelli
authors.forename: A
authors.initials: A
authors.lastname: Aceto
mesh_terms: D000818:Animals; D005260:Female; D005456:Fluorescent Dyes; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009282:Naphthalenesulfonates; D010575:Pesticides / Q000378:metabolism*; D011485:Protein Binding; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D009282:Naphthalenesulfonates; D010575:Pesticides; C009497:2-(4-toluidino)-6-naphthalenesulfonic acid; D005982:Glutathione Transferase