title: A graphic digital database of Drosophila embryogenesis.
abstract: Modern studies of the genetic control of development have increased the need for an accurate and comprehensive storage and display of gene expression data. This can be achieved in the form of an electronic graphic database of development. Here, we introduce the first steps towards a database of Drosophila embryogenesis. For each morphologically defined stage, a complete series of histological and/or optical sections are generated (optical sections are generated by laser confocal microscopy). Digitized sections are imported into a drawing program where they serve as templates to define the contours of organs and the position of individual cells. From these data, surface and point cloud models of all developmental stages are generated. Gene expression data can be entered by translating the expression domain of a given gene into the three-dimensional coordinate system of the database.
authors.affiliation: Department of Biology, University of California at Los Angeles 90024.
authors.forename: V
authors.initials: V
authors.lastname: Hartenstein
authors.forename: A
authors.initials: A
authors.lastname: Lee
authors.forename: A W
authors.initials: AW
authors.lastname: Toga
mesh_terms: D000703:Analog-Digital Conversion; D000818:Animals; D003196:Computer Graphics; D016208:Databases, Factual; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D004625:Embryo, Nonmammalian / Q000648:ultrastructure; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008953:Models, Anatomic; D009024:Morphogenesis