title: Osteogenesis in muscle with composite graft of hydroxyapatite and autogenous calvarial periosteum: a preliminary report.
abstract: To investigate the bone forming activity of composite grafts of hydroxyapatite (HA) and autogenous calvarial periosteum, porous HA rods with or without the periosteum were implanted into the back muscle of white rabbits. They were harvested 3 and 6 months after implantation and studied histologically and microradiographically. Bone formation in the pores of HA occurred in three out of four composite implants of the 3 month group, and four out of five implants of the 6 month group. The two specimens without bone formation revealed irregular calcified tissue outside the HA implant. No formation of bone and calcified tissue took place in any of the specimens with HA alone. These results indicate the potential of this new experimental system of ectopic osteogenesis and offer the possibility of a new improved bone graft consisting of HA and autogenous periosteum.
authors.affiliation: Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kurashina
authors.forename: H
authors.initials: H
authors.lastname: Kurita
authors.forename: H
authors.initials: H
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Hirano
authors.forename: C P
authors.initials: CP
authors.lastname: Klein
authors.forename: K
authors.initials: K
authors.lastname: de Groot
mesh_terms: D000818:Animals; D006882:Hydroxyapatites; D009132:Muscles / Q000502:physiology* / Q000601:surgery; D016348:Osseointegration / Q000187:drug effects*; D010521:Periosteum / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000637:transplantation; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D011859:Radiography; D012886:Skull / Q000601:surgery* / Q000648:ultrastructure; D013997:Time Factors; D016042:Transplantation, Heterotopic / Q000379:methods
chemical_list: D006882:Hydroxyapatites