title: Why does the human visual system age in the way it does?
abstract: The tentative observation that the decrease of lenticular glutathione in man and in cattle may be under genetic control is extended to other biological functions which show a systematic reduction with age. Ocular and visual parameters are shown to decline consistently with the view that the human eye has evolved in keeping with other biological functions sustaining a life-span of approximately 120 years. Analysis of the data suggests that presbyopia represents an outlier in the distribution of ocular attributes, and should not be used as a biomarker for ageing.
authors.affiliation: Age Concern Institute of Gerontology, King's College London.
authors.forename: R
authors.initials: R
authors.lastname: Weale
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism; D008136:Longevity; D009799:Ocular Physiological Phenomena; D011305:Presbyopia / Q000209:etiology*; D014785:Vision, Ocular / Q000502:physiology
chemical_list: D005978:Glutathione