Evaluation of the portal venous system before liver transplantation: value of phase-contrast MR angiography.
OBJECTIVE
The purpose of this study was to assess the accuracy of phase-contrast MR angiography with gadolinium in evaluating the patency and blood flow direction of the portal venous system; the presence, extent, and type of varices; and the patency of surgical decompressive shunts in patients before liver transplantation. This information is essential in management and care of patients with chronic liver disease and portal hypertension and those who are candidates for liver transplantation.


METHODS
Twenty-four patients with portal venous hypertension were evaluated with phase-contrast MR angiography. Two patients had surgical splenorenal shunts and one had a mesocaval shunt. Phase-contrast angiograms were acquired as a series of two-dimensional sequential coronal sections during breath-holding and after IV administration of gadopentetate dimeglumine. Correlative findings from color flow Doppler sonography, contrast-enhanced CT scanning, and conventional angiography were available in 23, 20, and 10 patients, respectively, and were used as standards. The images from each technique were analyzed independently for patency of and flow direction in the portal vein, splenic vein, superior mesenteric vein, and surgically created shunts, and for detection, distribution, and extent of five variceal groups.


RESULTS
Findings from phase-contrast MR angiography completely agreed with those of sonography, CT scanning, and conventional angiography. The main portal vein was patent in 18 patients, stenosed in one, partially thrombosed in one, and occluded in four. Phase-contrast MR angiography correctly showed hepatofugal flow in three patients and hepatopetal flow in 17 patients. Both the splenic and superior mesenteric veins were patent in 20, partially thrombosed in one, and occluded in three cases. Phase-contrast MR angiograms showed 85% of the variceal groups, and MR rating of variceal size was not significantly different from that of CT rating. Phase-contrast MR angiography correctly showed the patency of all three surgical decompressive shunts.


CONCLUSIONS
Phase-contrast MR angiography is accurate for evaluating the patency and flow direction of the portal venous system, detecting and determining the distribution and extent of varices, and assessing the patency of surgically created shunts. Therefore, it is a reliable and noninvasive technique that can provide crucial information in the preoperative workup of liver transplant recipients.
Nghiem
H V
HV
University of Washington, Department of Radiology, Seattle 98195, USA.
Winter
T C
TC
Mountford
M C
MC
Mack
L A
LA
Yuan
C
C
Coldwell
D M
DM
Althaus
S J
SJ
Carithers
R L
RL
McVicar
J P
JP
Freeny
P C
PC
D000328:Adult; D000368:Aged; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D016031:Liver Transplantation; D018810:Magnetic Resonance Angiography; D008297:Male; D008536:Meglumine; D008642:Mesenteric Veins / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000473:pathology*; D011170:Portasystemic Shunt, Surgical; D013162:Splenic Vein / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014648:Varicose Veins / Q000175:diagnosis / Q000000981:diagnostic imaging; D014654:Vascular Patency
D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA