title: Poststroke depression. Is there a pathoanatomic correlate for depression in the postacute stage of stroke?
abstract: OBJECTIVE
  This study is aimed at the pathoanatomic correlates of depression in the postacute stage of patients with stroke.
  
  
  METHODS
  Of a consecutive series of 104 stroke patients, a subgroup of 47 patients with single demarcated unilateral lesions was selected. Clinical examination, neuroradiological CT scan examination, and psychiatric assessment were performed within a 2-month period after the acute stroke. Depression was assessed with the Cornell Depression Scale, the Montgomery-Asberg Depression Rating Scale, and according to modified DSM-III-R criteria. The neuroradiological examination of all patients was performed on the same scanner, and lesion location, lesion volume, and ventricle-to-brain ratio were analyzed.
  
  
  RESULTS
  We found no significant differences in depression scores between patients with left and right hemisphere lesions and no correlation between the severity of depression and the anteriority and the volume of lesion or brain atrophy. Major depressive disorders were only found in nine patients with left hemisphere lesions, all involving the basal ganglia, whereas none of the patients with right hemisphere stroke exhibited major depression.
  
  
  CONCLUSIONS
  Lesions in the vicinity of the left hemisphere basal ganglia tend to play a crucial role in the development of major depression after the acute stage of stroke. The pathophysiological implications of this finding are discussed.
authors.affiliation: Department of Rehabilitation Psychology, University of Freiburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Herrmann
authors.forename: C
authors.initials: C
authors.lastname: Bartels
authors.forename: M
authors.initials: M
authors.lastname: Schumacher
authors.forename: C W
authors.initials: CW
authors.lastname: Wallesch
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000000981:diagnostic imaging; D003863:Depression / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D011594:Psychometrics; D014057:Tomography, X-Ray Computed