[Dynamics of a series of parameters of cellular and humoral immunity in patients with diabetes mellitus type I].
Fifty-two patients with type I diabetes mellitus were examined. The patients were divided into 4 groups with various duration of the disease: group 1 included patients with the newly diagnosed disease, group 2 those with disease standing of 1 to 5 years, group 3 were patients suffering from diabetes for 6 to 10 years, and group 4 were diabetics for 10 years and more. The parameters examined were antibodies to surface antigens of islet cells, absolute and relative counts of T and B lymphocytes in the peripheral blood, counts of T- helpers and T-suppressors and cytotoxic cells and their ratios, counts of natural killers, DR (+) and JgG (+) cells, and basal C-peptide level. The results showed a correlation between autoantibodies to surface antigens of islet cells and the count of B lymphocytes, an inversion of T lymphocyte subpopulations, with the helper/suppressor index increased at the initial stages of the disease and decreasing with the disease progress.
Pometkin
V V
VV
Nikonova
T V
TV
Brykova
S V
SV
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D001323:Autoantibodies / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007515:Islets of Langerhans / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D018655:Lymphocyte Count; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D001323:Autoantibodies
Dinamika riada pokazateleĭ kletochnogo i gumoral'nogo immuniteta u bol'nykh sakharnym diabetom I tipa.