Adrenogenital syndrome caused by an androgen-producing adrenocortical tumor.
We describe here a typical case of virilizing adrenocortical tumor. A 23-year-old Japanese woman had her male-like musculature, hirsutism, the absence of breast development and marked clitoromegaly. Adrenal androgens were remarkably elevated, with plasma dehydroepiandrosterone sulfate 2,752 micrograms/dl, plasma testosterone 250 ng/dl and urinary 17-ketosteroids 203.4 mg/day. A well-encapsulated tumor approximately 7 cm in diameter was detected in the left adrenal gland by computed tomography, magnetic resonance imaging and arteriography. The tumor was surgically resected and histologically diagnosed as a benign adrenocortical adenoma. The elevated adrenal androgens returned to normal postoperatively with amelioration of her masculinized clinical features.
Sakuma
T
T
Department of Medicine, Kobe University School of Medicine.
Yamaguchi
T
T
Abe
H
H
Kanda
F
F
Hanioka
K
K
Hisano
K
K
Ito
H
H
Okada
M
M
Chihara
K
K
D000236:Adenoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000312:Adrenal Hyperplasia, Congenital / Q000209:etiology* / Q000473:pathology; D000328:Adult; D000728:Androgens / Q000378:metabolism; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography
D000728:Androgens