The selective CCK-B agonist, BC 264, impairs socially reinforced memory in the three-panel runway test in rats.
The role of CCK-B receptor activation in memory processes has been reassessed using the three-panel runway task, under conditions which avoid the effects of CCK on satiety and reduce emotional responses. For this purpose the food reinforcement usually used was replaced by a social reinforcement. The results show that learning and memory can be assessed using this procedure. Moreover, under these experimental conditions, drugs such as scopolamine, amphetamine or kinurenic acid injected into the nucleus accumbens produced behavioral deficits. BC 264, a highly selective CCK-B agonist, peripherally administered or infused into the anterolateral part of the nucleus accumbens also impaired memory. These effects were suppressed by L-365,260 supporting the involvement of CCK-B receptors and of the nucleus accumbens in memory processes.
Derrien
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M
Unité de Pharmacochimie Moléculaire et Structurale, U 266 INSERM-URA 1500 CNRS, Université René Descartes (Paris V), France.
Daugé
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V
Blommaert
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A
Roques
B P
BP
D000595:Amino Acid Sequence; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D002766:Cholecystokinin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004644:Emotions / Q000187:drug effects; D005508:Food Deprivation; D007267:Injections; D008297:Male; D008568:Memory / Q000187:drug effects*; D008969:Molecular Sequence Data; D009714:Nucleus Accumbens; D010446:Peptide Fragments / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010671:Phenylurea Compounds; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000819:agonists* / Q000037:antagonists & inhibitors; D012054:Reinforcement, Psychology; D012919:Social Behavior
C084553:BC 264; D001570:Benzodiazepinones; D010446:Peptide Fragments; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C058121:L 365260; D002766:Cholecystokinin