The putative Drosophila NMDARA1 gene is located on the second chromosome and is ubiquitously expressed in embryogenesis.
We describe the cDNA sequence of a Drosophila gene located at 49D on the second chromosome. The predicted protein sequence has extensive homology (46% identity, 76% similarity) along its entire length to the central portion of the mammalian brain-specific NMDARA1 glutamate binding protein. While RNA expression studies of the Drosophila protein shown that it is ubiquitously expressed throughout embryogenesis, there appears to be a selective accumulation of transcript in the precursor for the larval brain. The similarity in both expression and sequence suggests that the two proteins may share a conserved function.
Pellicena-Pallé
A
A
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106-4955, USA.
Salz
H K
HK
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000737:chemistry; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D007814:Larva; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry*; D016415:Sequence Alignment
D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate