title: [Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats].
abstract: Experiments were carried on rats to study the preventive effects of calcium channel blockers Nitrendipine, Nifedipine and L-Arginine (L- Arginine is the physiological precursor of nitric oxide in endothelium-dependent relaxation) on chronic intermittent hypoxia induced pulmonary hypertension, on the right ventricular hypertrophy and pulmonary vascular pathologic changes. The results showed (1) Nitrendipine, Nifedipine and L-arginine played significant role in preventing chronic hypoxic pulmonary hypertension and the right ventricular hypertrophy. (2) There was no significant difference between Nitrendipine, Nifedipine and L- arginine in preventing hypoxic pulmonary hypertension (P > 0.05). (3) Nitrendipine was better than Nifedipine in reducing the hypoxic pulmonary hypertension.
authors.affiliation: Guangzhou Institute of Respiratory Diseases.
authors.forename: M R
authors.initials: MR
authors.lastname: Li
authors.forename: S C
authors.initials: SC
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Ma
mesh_terms: D000818:Animals; D001120:Arginine / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000517:prevention & control*; D017380:Hypertrophy, Right Ventricular / Q000517:prevention & control*; D000860:Hypoxia / Q000150:complications*; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use; D009568:Nitrendipine / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001120:Arginine; D009568:Nitrendipine; D009543:Nifedipine