title: Synthesis, physico-chemical and biological properties of some alkali metals and quaternary alkylammonium salts of polyene antibiotics: amphotericin B, nystatin and aureofungin.
abstract: Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method. The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent compounds. While the majority of the salts reported herein showed more water solubility; triethylammonium salts, unlike the other alkali metal salts, possessed marginally improved or similar bioactivity in comparison to their parent antibiotic having reduced toxicity.
authors.affiliation: Hindustan Antibiotics Ltd., Pimpri, Pune.
authors.forename: N R
authors.initials: NR
authors.lastname: Chatterjee
authors.forename: V M
authors.initials: VM
authors.lastname: Badave
authors.forename: D A
authors.initials: DA
authors.lastname: Pawar
mesh_terms: D000666:Amphotericin B / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008670:Metals / Q000737:chemistry; D009761:Nystatin / Q000737:chemistry* / Q000494:pharmacology; D011090:Polyenes / Q000737:chemistry / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D008670:Metals; D011090:Polyenes; D000644:Quaternary Ammonium Compounds; D009761:Nystatin; D000666:Amphotericin B; C034048:aureofungin