[Effects of Onpi-to (TJ-8117) on mesangial injury induced by anti Thy-1 antibody].
We investigated the effect of Onpi-to (TJ-8117) on the mesangial injury induced by anti-Thy-1 antibody. TJ-8117 (400 mg/kg/day, p.o.) given from the 1st day (from the day of injection of the anti-thymocyte serum) or 4th day (after mesangial proliferation), markedly inhibited the mesangial proliferation and hypercellularity in glomeruli. TJ-8117 prevented the increase in the number of PCNA or ED-1 positive cells in glomeruli. These results suggest that TJ-8117 is effective against glomerular disease with mesangial injury.
Hattori
T
T
Tsumura Central Laboratories, Ibaraki, Japan.
Shindo
S
S
Hisada
T
T
Fujitsuka
N
N
Hibino
T
T
Terazono
Y
Y
Maruno
M
M
D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018800:Thy-1 Antigens
D004365:Drugs, Chinese Herbal; D018800:Thy-1 Antigens; C093447:onpi-to