Photodynamic action increases leakage of the mitochondrial electron transport chain.
Rat liver submitochondrial particles were treated with rose bengal or flavin mononucleotide and irradiated with visible or near UV light. In both cases, oxygen consumption is impaired after irradiation while O2-. production increases significantly. This suggests that exogenous or endogenous photosensitizers can induce more electron leakage in the mitochondrial respiratory chain. Photobiological implications in dermatology are discussed.
Salet
C
C
Laboratoire de Biophysique, INSERM U 201, CNRS URA 481, Muséum National d'Histoire Naturelle, Paris, France.
Moreno
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G
D000818:Animals; D004579:Electron Transport; D005486:Flavin Mononucleotide / Q000494:pharmacology; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism* / Q000528:radiation effects; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D010778:Photochemotherapy; D051381:Rats; D017208:Rats, Wistar; D012395:Rose Bengal / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D012395:Rose Bengal; D005486:Flavin Mononucleotide; D013482:Superoxide Dismutase