The effect of the perflubron emulsion Oxygent on the calibration characteristics of polarographic oxygen electrodes.
The perfluorocarbon emulsion Oxygent improves normal tissue oxygenation. A clinical trial is planned to evaluate this effect in tumors. Polarographic oxygen electrodes were calibrated in solutions of saline +/- perflubron to assess whether Oxygent influenced probe behavior. Calibrations were linear under both conditions. There were no major differences in estimated oxygen tensions.
Brizel
D M
DM
Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, NC 27710, USA.
Dodge
R
R
Dewhirst
M W
MW
D002138:Calibration; D004655:Emulsions; D005466:Fluorocarbons / Q000494:pharmacology*; D006801:Humans; D006842:Hydrocarbons, Brominated; D066298:In Vitro Techniques; D010100:Oxygen / Q000032:analysis; D011048:Polarography / Q000295:instrumentation*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D011838:Radiation-Sensitizing Agents; C003072:perflubron; D010100:Oxygen