title: Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?
abstract: The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients. The response to chemotherapy was significantly better in patients with tumours with a high SPF, and in addition the time to progression was longer in the high-SPF group. There was no significant difference when the DNA ploidy and response to treatment were compared.
authors.affiliation: Department of Radiotherapy and Oncology, University Central Hospital of Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Hietanen
authors.forename: C
authors.initials: C
authors.lastname: Blomqvist
authors.forename: V M
authors.initials: VM
authors.lastname: Wasenius
authors.forename: E
authors.initials: E
authors.lastname: Niskanen
authors.forename: K
authors.initials: K
authors.lastname: Franssila
authors.forename: S
authors.initials: S
authors.lastname: Nordling
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004273:DNA, Neoplasm / Q000235:genetics*; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D011003:Ploidies; D011237:Predictive Value of Tests; D016196:S Phase / Q000502:physiology*; D012983:Soft Tissue Neoplasms / Q000556:secondary
chemical_list: D004273:DNA, Neoplasm; D015251:Epirubicin; D003520:Cyclophosphamide; D005472:Fluorouracil