title: Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance.
abstract: The effect of the structure of human milk triglycerides on intestinal fat absorption remains controversial. Twelve infants were each fed, for 1 wk in a crossover design, two formulas that differed only in triglyceride configuration. The "beta" formula contained triglycerides similar to those in human milk (26% palmitic acid, esterified predominantly to the sn-2 position) whereas in the "alpha" formula, which contained triglycerides similar to those in formulas currently marketed, palmitate was mainly at the sn-1,3 positions. Fatty acid, fat, and mineral balances were measured at the end of each 1-wk period. Myristic, palmitic, and stearic acids were absorbed better from the beta formula, but total fat excretion was not reduced. During the feeding of beta formula fecal calcium excretion was lower, urinary calcium higher, and urinary phosphate lower. A formula containing triglycerides similar to those in human milk has significant effects on fatty acid intestinal absorption and improves mineral balance in comparison with a conventional formula.
authors.affiliation: Department of Pediatrics, Sophia Children's Hospital, Rotterdam, Netherlands.
authors.forename: V P
authors.initials: VP
authors.lastname: Carnielli
authors.forename: I H
authors.initials: IH
authors.lastname: Luijendijk
authors.forename: J B
authors.initials: JB
authors.lastname: van Goudoever
authors.forename: E J
authors.initials: EJ
authors.lastname: Sulkers
authors.forename: A A
authors.initials: AA
authors.lastname: Boerlage
authors.forename: H J
authors.initials: HJ
authors.lastname: Degenhart
authors.forename: P J
authors.initials: PJ
authors.lastname: Sauer
mesh_terms: D000284:Administration, Oral; D002118:Calcium / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D005227:Fatty Acids / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D005243:Feces / Q000737:chemistry; D006801:Humans; D007225:Infant Food / Q000592:standards*; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism / Q000502:physiology*; D007408:Intestinal Absorption; D050356:Lipid Metabolism; D008895:Milk, Human / Q000737:chemistry / Q000502:physiology*; D008903:Minerals / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D014280:Triglycerides / Q000737:chemistry / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D008903:Minerals; D010169:Palmitic Acids; D014280:Triglycerides; D019308:Palmitic Acid; D002118:Calcium