[Studies on the possibility of using lyophilized in vitro autogenic bone marrow derived stromal cells to stimulate healing of bone lesions in the jaws].
The authors describe a new method of stimulation of regeneration of bone tissue using autografts of autologous bone marrow supplemented with autologous bone marrow stromal fibroblastoid cells (with osteogenic potential) grown in vitro and lyophilized allogenic bone. Such composite grafts have been used in the treatment of 10 patients with lesion in jaw bone. Bone healing was evaluated using clinical and radiological parameters and was compared with healing in 30 similar lesions treated using composite grafts of autologous bone marrow and allogenic lyophilized bone as well as the spontaneous healing of 45 post-cystic lesions. These data indicate, that composite grafts of autologous bone marrow supplemented with in vitro grown autologous bone marrow stromal cells and lyophilized allogenic bone have excellent capacities accelerating bone healing. In smaller lesions, composite grafts of fresh autologous bone marrow and allogenic lyophilized bone (which are easier to prepare) are also useful.
Krzymański
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G
Kliniki Chirurgii Szczekowej IS, Centralnego Szpitala Klinicznego Wojskowej Akademii Medycznej w Warszawie.
Jedrzejczak
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WW
D000293:Adolescent; D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D001861:Bone Regeneration / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000637:transplantation*; D005612:Freeze Drying; D006801:Humans; D007570:Jaw Cysts / Q000150:complications; D007571:Jaw Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D014945:Wound Healing / Q000502:physiology
Badania nad mozliwościa uzycia namnozonych in vitro autogennych komórek podścieliska szpiku do pobudzania gojenia ubytków tkanki kostnej szczek.