title: Analysis of immunoassays to detect antibodies to hepatitis A virus (anti-HAV) and anti-HAV immunoglobulin M.
abstract: Two newly developed anti-HAV tests were assessed, using a total of 1835 sera. These two tests are being distributed under the trademarks Enzymun-Test anti-HAV and Enzymun-Test IgM anti-HAV. The anti-HAV test was compared to anti-HAV tests from other manufacturers and featured a high sensitivity combined with a high level of reproducibility and specificity. In terms of sensitivity, reproducibility and specificity, the IgM test proved to be comparable to other IgM anti-HAV tests used for the diagnosis of acute type A hepatitis. Combining both tests was shown to be useful to recognize an acute or past hepatitis A virus infection. In addition, the high sensitivity of the anti-HAV test makes this test extremely useful to assess the immunoresponse to the hepatitis A vaccine.
authors.affiliation: Boehringer Mannheim GmbH, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Hess
authors.forename: E
authors.initials: E
authors.lastname: Faatz
authors.forename: W
authors.initials: W
authors.lastname: Melchior
authors.forename: H
authors.initials: H
authors.lastname: Bayer
mesh_terms: D005260:Female; D006506:Hepatitis A / Q000175:diagnosis; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D007075:Immunoglobulin M; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines