Effect of aging on urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone.
19-Noraldosterone, recently shown to be produced in the human adrenal gland, possesses potent mineralocorticoid and hypertensinogenic activity. A possible precursor, 18,19-dihydroxycorticosterone, has been identified in human urine, with both steroids acutely regulated by the renin-angiotensin system. The secretion of aldosterone declines with advancing age. To elucidate the effect of aging on the urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone, we measured their urinary concentrations in 51 normotensive subjects aged 20-70 years. We observed significant negative correlations between age and the urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone (r = -0.69, r = -0.65, P < 0.05, respectively). Urinary and plasma aldosterone and PRA similarly decreased with aging. These results suggest that 19-noraldosterone may be chronically regulated in part by the renin-angiotensin system.
Takeda
Y
Y
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Miyamori
I
I
Yoneda
T
T
Iki
K
K
Takeda
R
R
D015069:18-Hydroxycorticosterone / Q000031:analogs & derivatives* / Q000652:urine; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000450:Aldosterone / Q000031:analogs & derivatives* / Q000652:urine; D006801:Humans; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D012083:Renin / Q000652:urine; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000652:urine
C051957:18,19-dihydroxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; C027514:19-noraldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium