Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXVIII: Oligoamines with fluorescent properties. Part C: Fluorescent oligoamines with enhanced hydrophilic properties.
Fifteen fluorescent oligoamines with one or two fluorescent groups and two or three basic N-functions were prepared and tested for antiplatelet activity (Born-test). Five compounds involving three different fluorophores, i.e. 2-fluorenyl, 1-pyrenyl, and 9-phenanthryl, show an IC50 of 7-11 mumol/L. They are suitable to serve as probes in the field of oligoamine-biopolymere interactions.
Rehse
K
K
Institut für Pharmazie, Freien Universität Berlin, Dahlem.
Seidel
T
T
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D000588:Amines; D005456:Fluorescent Dyes; D010975:Platelet Aggregation Inhibitors