Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex.
The third subunit, the so-called common gamma (gamma c) chain, of the IL-2 receptor is shared among the receptors for IL-2, IL-4, IL-7 and IL-15, and dysfunction of the gamma c chain is thought to cause X-linked severe combined immunodeficiency (XSCID) ascribed to impairment of early T cell development. However, cytokines linked to XSCID are as yet unidentified. A mAb specific for the gamma c chain, TUGm2, profoundly inhibited cell proliferation in response to IL-9. Another mAb, TUGm3, immunoprecipitated [125I]IL-9 cross-linked with either the IL-9 receptor or the gamma c chain. These results demonstrate that the gamma c chain is included in the functional receptor complex for IL-9, which was initially characterized as a T cell growth factor and is essential for IL-9-dependent growth signal transduction.
Kimura
Y
Y
Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.
Takeshita
T
T
Kondo
M
M
Ishii
N
N
Nakamura
M
M
Van Snick
J
J
Sugamura
K
K
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002478:Cells, Cultured; D066298:In Vitro Techniques; D016906:Interleukin-9 / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D046911:Macromolecular Substances; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D018123:Receptors, Interleukin / Q000737:chemistry*; D015375:Receptors, Interleukin-2 / Q000737:chemistry*; D053651:Receptors, Interleukin-9; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D016906:Interleukin-9; D046911:Macromolecular Substances; D018123:Receptors, Interleukin; D015375:Receptors, Interleukin-2; D053651:Receptors, Interleukin-9