title: Differences in lymphocyte proliferative responses to food antigens and specific IgE antibodies to foods with age among food-sensitive patients with atopic dermatitis.
abstract: BACKGROUND
  Clinical symptoms of patients with food-sensitive atopic dermatitis often improve with increasing age.
  
  
  OBJECTIVE
  To investigate this tendency and the underlying mechanism.
  
  
  METHODS
  We selected and divided 194 food-sensitive atopic dermatitis patients into three age groups. The proliferative responses of peripheral blood mononuclear cells (PBMCs) to food antigens and specific IgE antibodies to foods then were evaluated with respect to age. We also followed up 55 food-sensitive patients with atopic dermatitis and examined their improvement ratio after 1 year. Further, we investigated changes in lymphocyte proliferative responses to food antigens and specific IgE antibodies to foods in food-sensitive patients with atopic dermatitis during elimination diets.
  
  
  RESULTS
  Proliferative responses of PBMCs to ovalbumin of patients in the over 6-years-old group were significantly (P < .05) lower than those of the less than 1-year-old group. Proliferative responses of PBMCs to bovine serum albumin of patients in the over 6-years-old group were significantly (P < .05) lower than those in the 1 to 5-year-old group and in the less than 1-year-old group. RAST values for hen egg in the over 6-years-old group were significantly (P < .05) lower than those for the less than 1-year-old group. Improvement was shown by 13 of the 33 hen egg-sensitive patients with atopic dermatitis, an improvement ratio of 39%, and by 9 of the 22 cow milk-sensitive patients with atopic dermatitis, an improvement ratio of 41%. Proliferative responses of PBMCs to food antigens in food-sensitive patients with atopic dermatitis decreased rapidly after patients were placed on elimination diets.
  
  
  CONCLUSIONS
  The PBMC proliferative responses to food antigens and RAST values were higher for young children and lower for older ones who suffered from food-sensitive atopic dermatitis. Oral tolerance, in addition to the development of digestive and absorptive functions, may be responsible for these immunologic changes.
authors.affiliation: Department of Pediatrics, Gifu University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iida
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Agata
authors.forename: S
authors.initials: S
authors.lastname: Shinoda
authors.forename: M
authors.initials: M
authors.lastname: Shinbara
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: O
authors.initials: O
authors.lastname: Fukutomi
authors.forename: T
authors.initials: T
authors.lastname: Orii
mesh_terms: D000293:Adolescent; D000818:Animals; D000941:Antigens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology*; D015387:Egg Proteins, Dietary / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007223:Infant; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008892:Milk / Q000009:adverse effects / Q000276:immunology*; D016269:Milk Hypersensitivity / Q000276:immunology; D011852:Radioallergosorbent Test; D012720:Severity of Illness Index
chemical_list: D000941:Antigens; D015387:Egg Proteins, Dietary; D007073:Immunoglobulin E