title: Population genetic study among the Orange Asli (Semai Senoi) of Malaysia: Malayan aborigines.
abstract: A population genetic study was undertaken to provide gene frequency data on the additional blood genetic markers in the Semai and to estimate the genetic relations between the Semai and their neighboring and linguistically related populations by genetic distance and principal components analyses. Altogether 10 polymorphic and 7 monomorphic blood genetic markers (plasma proteins and red cell enzymes) were studied in a group of 349 Senoi Semai from 11 aboriginal settlements (villages) in the Pahang State of western Malaysia. Both the red cell glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (PGD) loci reveal the presence of polymorphic frequencies of a nondeficient slow allele at the G6PD locus and a fast allele at the PGD locus. The Semai are characterized by high prevalences of ahaptoglobinemia and G6PD deficiency, high frequencies of HP*1, HB*E, RH*R1, ACP*C, GLO1*1, PGM1*2+, and GC*1F and corresponding low frequencies of ABO*A, HbCoSp, HB*B0, TF*D, CHI, and GC*2. Genetic distance analyses by both cluster and principal components models were performed between the Semai and 14 other populations (Malay; Javanese; Khmer; Veddah; Tamils of Malaysia, Sri Lanka, and India; Sinhalese; Oraon; Toda and Irula of India; Chinese; Japanese; Koreans) on the basis of 30 alleles at 7 polymorphic loci. A more detailed analysis using 53 alleles at 13 polymorphic loci with 10 populations was carried out. Both analyses give genetic evidence of a close relationship between the Semai and the Khmer of Cambodia. Furthermore, the Semai are more closely related to the Javanese than to their close neighbors--the Malay, Chinese, and Tamil Indians. There is no evidence for close genetic relationship between the Semai and the Veddah or other Indian tribes. The evidence fits well with the linguistic relationship of the Semai with the Mon-Khmer branch of the Austro-Asiatic language family.
authors.affiliation: Department of Pediatrics, National University of Singapore.
authors.forename: N
authors.initials: N
authors.lastname: Saha
authors.forename: J W
authors.initials: JW
authors.lastname: Mak
authors.forename: J S
authors.initials: JS
authors.lastname: Tay
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: J A
authors.initials: JA
authors.lastname: Tan
authors.forename: P S
authors.initials: PS
authors.lastname: Low
authors.forename: M
authors.initials: M
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001798:Blood Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers; D005828:Genetics, Population; D005954:Glucosephosphate Dehydrogenase / Q000097:blood / Q000235:genetics*; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D010734:Phosphogluconate Dehydrogenase / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D044469:Racial Groups
chemical_list: D001798:Blood Proteins; D005819:Genetic Markers; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase