[Antibiotic resistance of Campylobacter strains and its role in evolutionary processes in bacteria of the genus Campylobacter].
The influence of multiple antibiotic resistance of Campylobacter strains determined by R plasmids on their virulence was studied. It was shown that the strains with multiple resistance were mostly isolated from children with campylobacteriosis (26.5 per cent). The number of such strains isolated from the infected adults, hens and environmental objects amounted to 25.8, 23.3 and 21.4 per cent respectively. The difference of the resistance determinants in the tested strains was statistically insignificant. It was suggested that the R plasmids of the human strains could be as well detected in the strains from the infected hens and environmental objects. A chromosome-plasmid pattern of the Campylobacter resistance to kanamycin, tetracycline and erythromycin was determined. The analysis of the cytopathogenic activity of the plasmid-containing strains and their aplasmid clones revealed that this criterion of the virulence statistically significantly increased after the plasmid loss by the strains. It was concluded that the antibiotic resistant strains had a selective superiority while circulating in various ecological niches.
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D000328:Adult; D005075:Biological Evolution; D002167:Campylobacter / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity; D002648:Child; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006801:Humans; D008826:Microbial Sensitivity Tests; D011815:R Factors; D014774:Virulence
Antibiotikorezistentnost' kampilobakteriĭ i ee rol' v protsessakh évoliutsii bakteriĭ roda Campylobacter.