Paromomycin-associated pancreatitis in HIV-related cryptosporidiosis.
OBJECTIVE
To report a case of pancreatitis related to paromomycin administration.


METHODS
A 39-year-old man with AIDS developed pancreatitis concurrent with successful treatment of intestinal cryptosporidiosis with paromomycin. The hyperamylasemia resolved with discontinuation of the agent and recurred when paromomycin treatment was reinstituted.


CONCLUSIONS
To our knowledge, this is the first reported case of pancreatitis believed to be induced by paromomycin. Although pancreatitis in HIV-infected patients has multiple causes, the nature of this case suggests the involvement of paromomycin. The mechanism of action is unclear.


CONCLUSIONS
Pancreatitis should be considered in the differential diagnosis of abdominal pain in patients who are treated with paromomycin.
Tan
W W
WW
Department of Medicine, Maimonides Medical Center, Brooklyn, NY 11219.
Chapnick
E K
EK
Abter
E I
EI
Haddad
S
S
Zimbalist
E H
EH
Lutwick
L I
LI
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D003457:Cryptosporidiosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D010303:Paromomycin / Q000009:adverse effects* / Q000627:therapeutic use
D010303:Paromomycin