A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis.
In experimental allergic encephalomyelitis (EAE), circulating leukocytes enter the central nervous system (CNS) producing inflammation, myelin damage and paralysis. Prevention of leukocyte infiltration by an antibody against alpha 4 integrin suppressed clinical and pathological features of EAE in the guinea pig. Rapid clearance of leukocytes from the CNS and reversal of clinical findings were observed when anti-alpha 4 treatment was administered during active disease. Clinical improvement was accompanied by a marked decrease in abnormal pathological findings, including demyelination. Therefore anti-alpha 4 is an effective treatment of EAE and may be similarly useful in the treatment of autoimmune diseases such as multiple sclerosis.
Kent
S J
SJ
Department of Diagnostic Radiology and Nuclear Medicine, University Hospital, University of Western Ontario, London, Canada.
Karlik
S J
SJ
Cannon
C
C
Hines
D K
DK
Yednock
T A
TA
Fritz
L C
LC
Horner
H C
HC
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D004334:Drug Administration Schedule; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D005260:Female; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D039441:Integrin alpha4; D016023:Integrins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D013116:Spinal Cord / Q000473:pathology; D013997:Time Factors; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D016023:Integrins; D039441:Integrin alpha4; D005620:Freund's Adjuvant