title: Quantitative assessment of dentin bridge formation following pulp-capping in miniature swine.
abstract: A quantitative assessment of dentin bridges was conducted on sections prepared from teeth capped with four pulp-capping agents (Bioglass, Life, Demineralized Dentin Matrix, and Teflon) in a micro-swine model. The degree of mineralization of the dentin bridges relative to the adjacent primary dentin was measured using a computer-based image analysis of microradiographs prepared from the sections. The rate of formation of the dentin bridge was measured from fluorescent bands formed in the same sections by a Demeclocycline dentin marker. There were no statistically significant differences in the relative mineral densities of the dentin bridges and the rate of dentin bridge formation under the four pulp-capping agents. These findings support the suggestion that components of the extracellular matrix rather than pulp-capping agents may be important in the formation and mineralization of dentin bridges in repairing dental pulps.
authors.affiliation: Department of Endodontics, University of Florida-Health Science Center, Gainesville 32610-0436, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Oguntebi
authors.forename: T
authors.initials: T
authors.lastname: Heaven
authors.forename: A E
authors.initials: AE
authors.lastname: Clark
authors.forename: F E
authors.initials: FE
authors.lastname: Pink
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002126:Calcium Hydroxide / Q000494:pharmacology; D002516:Ceramics / Q000494:pharmacology; D003707:Demeclocycline; D003764:Dental Materials / Q000494:pharmacology; D003782:Dental Pulp / Q000166:cytology / Q000187:drug effects; D003785:Dental Pulp Capping / Q000379:methods*; D003804:Dentin; D003809:Dentin, Secondary / Q000737:chemistry / Q000254:growth & development*; D003810:Dentinogenesis / Q000187:drug effects*; D007091:Image Processing, Computer-Assisted; D066298:In Vitro Techniques; D011138:Polytetrafluoroethylene / Q000494:pharmacology; D013552:Swine; D013556:Swine, Miniature
chemical_list: C022107:Bioglass; C093073:Demineralized Dentin Matrix; D003764:Dental Materials; D003707:Demeclocycline; C040408:Life (dental material); D011138:Polytetrafluoroethylene; D002126:Calcium Hydroxide