Effect of aspartate, asparagine, and carnitine supplementation in the diet on metabolism of skeletal muscle during a moderate exercise.
The present study examined the effect of diet supplementation of oxaloacetate precursors (aspartate and asparagine) and carnitine on muscle metabolism and exercise endurance. The results suggest that the diet supplementation increased the capacity of the muscle to utilize FFA and spare glycogen. Time to exhaustion was about 40% longer in the experimental group compared to the control, which received commercial diet only. These findings suggest that oxaloacetate may be important to determine the time to exhaustion during a prolonged and moderate exercise.
Lancha
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AH
Physical Education School, Biodynamic Department, São Paulo University, Brasil.
Recco
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MB
Abdalla
D S
DS
Curi
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R
D000818:Animals; D001216:Asparagine / Q000097:blood / Q000494:pharmacology*; D001224:Aspartic Acid / Q000097:blood / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D002331:Carnitine / Q000097:blood / Q000494:pharmacology*; D002950:Citrate (si)-Synthase / Q000378:metabolism; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010071:Oxaloacetates / Q000378:metabolism; D010084:Oxidation-Reduction; D010805:Physical Conditioning, Animal; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
D001786:Blood Glucose; D005227:Fatty Acids; D008112:Liver Glycogen; D010071:Oxaloacetates; D001224:Aspartic Acid; D001216:Asparagine; D006003:Glycogen; D002950:Citrate (si)-Synthase; D002331:Carnitine