title: Liver transplant after massive spontaneous hepatic rupture in pregnancy complicated by preeclampsia.
abstract: BACKGROUND
  Spontaneous hepatic rupture associated with preeclampsia is a rare but life-threatening situation. Several different surgical treatments have been described, depending on the severity of the rupture. Liver transplantation has become the mainstay for patients with end-stage liver disease. Transplantation in the setting of liver trauma or massive parenchymal disruption is not well defined. To our knowledge, this treatment has not been reported for spontaneous hepatic rupture in pregnancy.
  
  
  METHODS
  Massive, spontaneous hepatic rupture occurred in a patient at 36 weeks' gestation as a result of severe preeclampsia. Conventional surgical therapies were unsuccessful in controlling the massive hemorrhage. As a life-saving measure, the patient underwent total hepatectomy with the creation of an end-to-side portcaval shunt, thereby rendering the patient anhepatic. The patient was listed as urgently needing a liver for transplantation through the United Network for Organ Sharing. A suitable donor liver was located approximately 8 hours after the emergency hepatectomy. The patient underwent orthotopic liver transplantation after being maintained in an anhepatic state for almost 13 hours. The patient was discharged on postoperative day 41, suffering only from some ischemic lower extremity neuropathy secondary to hypovolemic hypotension occurring during the hepatectomy procedure.
  
  
  CONCLUSIONS
  In the reported case, spontaneous hepatic rupture resulted in a massive hemorrhage that could not be controlled by previously reported techniques and required total hepatectomy followed by liver transplantation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Hunter
authors.forename: M
authors.initials: M
authors.lastname: Martin
authors.forename: J A
authors.initials: JA
authors.lastname: Benda
authors.forename: F J
authors.initials: FJ
authors.lastname: Zlatnik
mesh_terms: D000328:Adult; D005260:Female; D006470:Hemorrhage; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008099:Liver / Q000098:blood supply; D008107:Liver Diseases / Q000150:complications* / Q000601:surgery; D016031:Liver Transplantation; D011167:Portacaval Shunt, Surgical; D011225:Pre-Eclampsia / Q000150:complications*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012422:Rupture, Spontaneous / Q000150:complications