[A case of mixed connective tissue disease associated with gastric cancer and cancer of the uterine cervix].
We report here a very rare case of MCTD complicating double cancer. A 43-year-old woman with suspected MCTD was admitted because of high fever and lymphadenopathy. The laboratory findings indicated high titers of speckled ANA, anti-RNP, DNA and Scl-70, but anti-Sm. SS-A and SS-B was not detected. Chest CT and Spirogram revealed lung fibrosis, restrictive ventilatory impairment, and decreased diffusion capacity. Biopsy specimen by gastric fiberscope s screening indicated II c advanced type of poorly differentiated adenocarcinoma. After subtotal gastrectomy, she had high fever, pleuritis, leukopenia, butterfly erythema and hypoxemia, which were improved by 30 mg/day of oral prednisolone. One year after from the last operation, she had contact bleeding, and squamous cell carcinoma of the uterine cervix was diagnosed. She had Raynaud's phenomenon 6 months after from hysterectomy.
Katayama
M
M
Division of Rheumatic Diseases, Tokyo Metropolitan Otsuka Hospital.
Tanaka
I
I
Hosako
Y
Y
Hama
N
N
Yamada
T
T
Inada
S
S
Goto
M
M
D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D005260:Female; D006801:Humans; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D009378:Neoplasms, Multiple Primary; D013274:Stomach Neoplasms / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000150:complications*