title: Outcome for infants with congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation: the first year.
abstract: Congenital diaphragmatic hernia (CDH) has been associated with a high mortality rate. The purposes of this study were to determine the impact of extracorporeal membrane oxygenation (ECMO) on the survival of infants with CDH and to document the sequelae and 1-year neurodevelopmental outcome for CDH infants who required ECMO. Thirty neonates with CDH were admitted between May 7, 1990 and October 1, 1992. Twenty required ECMO and were enrolled in our neonatal follow-up program. Information about the infants' neonatal course was obtained from chart review, and the infants were seen at 3, 6, and 12 months of age for medical and neurodevelopmental follow-up. Primary diaphragmatic repair was performed in 13 infants. Five required Goretex graft reconstruction (GGR), and two did not have repair. Sixteen (80%) of the 20 infants who required ECMO survived. The overall survival rate increased from 31% (10 of 32) in the 5 years previous to the start of the ECMO program to 63% (19 of 30) since then (P = .01). The most common sequelae noted by the time of discharge included gastroesophageal reflux (GER; 81%), the need for tube feeding (69%), and chronic lung disease (CLD; 62%). At 1 year of age, mean cognitive skills were average (87 +/- 23) and motor skills were borderline (75 +/- 24) according to the Bayley Scales of Infant Development. Hypotonia was present in 10 of 13 patients.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Neonatology, Children's Hospital of Philadelphia, PA 19104.
authors.forename: J A
authors.initials: JA
authors.lastname: D'Agostino
authors.forename: J C
authors.initials: JC
authors.lastname: Bernbaum
authors.forename: M
authors.initials: M
authors.lastname: Gerdes
authors.forename: I P
authors.initials: IP
authors.lastname: Schwartz
authors.forename: C E
authors.initials: CE
authors.lastname: Coburn
authors.forename: R B
authors.initials: RB
authors.lastname: Hirschl
authors.forename: S
authors.initials: S
authors.lastname: Baumgart
authors.forename: R A
authors.initials: RA
authors.lastname: Polin
mesh_terms: D000465:Algorithms; D001166:Arteriovenous Shunt, Surgical; D002657:Child Development / Q000502:physiology; D003131:Combined Modality Therapy; D015199:Extracorporeal Membrane Oxygenation; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000503:physiopathology; D006548:Hernia, Diaphragmatic / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D009017:Morbidity; D011138:Polytetrafluoroethylene; D011182:Postoperative Care; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D019736:Prostheses and Implants; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011138:Polytetrafluoroethylene