Study of the possible association of HLA class II, CD4, and CD3 polymorphisms with schizophrenia.
In the present study the HLA-DRB and DPB1 alleles as well as CD4 and CD3 polymorphisms were tested in 100 Belgian schizophrenic patients and 204 controls. Our results indicate a significant negative association of the DPB1 0101 allele with schizophrenia (relative risk [RR] = 0.27). Furthermore a significant positive and negative association could be noticed for the CD4*A4 allele and CD4*A7/A8 genotype, respectively (RR 1.79 and 0.47, respectively). These findings suggest that some contribution of HLA class II and CD4 genes to an autoimmune-like pathogenesis in schizophrenia might exist.
Zamani
M G
MG
Center for Human Genetics, University of Leuven, Belgium.
De Hert
M
M
Spaepen
M
M
Hermans
M
M
Marynen
P
P
Cassiman
J J
JJ
Peuskens
J
J
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D001483:Base Sequence; D017252:CD3 Complex / Q000235:genetics*; D015704:CD4 Antigens / Q000235:genetics*; D002648:Child; D017931:DNA Primers; D005260:Female; D006681:HLA-D Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors
D015703:Antigens, CD; D017252:CD3 Complex; D015704:CD4 Antigens; D017931:DNA Primers; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains