Structure of a new peptide, astin J, from Aster tataricus.
A new peptide called astin J (1) was isolated from the roots of Aster tataricus. The structure was elucidated by spectroscopic methods and chemical transformation from a cyclic pentapeptide, astin C, isolated from A. tataricus to the analogous acyclic peptide, 2. Antileukemic activities of the series of acyclic peptides are also described.
Morita
H
H
Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
Nagashima
S
S
Takeya
K
K
Itokawa
H
H
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000613:Aminobutyrates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002384:Catalysis; D002455:Cell Division / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D006801:Humans; D007624:KB Cells; D007939:Leukemia L1210 / Q000473:pathology; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010456:Peptides, Cyclic; D010940:Plant Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000378:metabolism*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D000596:Amino Acids; D000613:Aminobutyrates; D000972:Antineoplastic Agents, Phytogenic; D009842:Oligopeptides; D010456:Peptides, Cyclic; D010940:Plant Proteins; C093312:astin J; D004121:Dimethyl Sulfoxide