[The assessment of the nutritional status of patients with familial amyloid neuropathy type I (Corino Andrade's disease) who are candidates for orthotopic liver transplantation].
Corino Andrade's disease (Type I Family amyloidotic polyneuropathy) (FAP I) is a slow-evolving hereditary amyloidosis affecting, among other things, the digestive system, with the appearance of an amyloid deposit which produces a malabsorptive syndrome with diarrhea in those affected. At present, the only effective therapeutic option is orthotopic liver transplant (OLT): clearance from the hospital's transplant commission as a candidate requires, among other things, a prior nutritional study. We therefore proposed to carry out a nutritional assessment of these patients, comparing them with a group of terminal liver patients who are OLT candidates. The PAF I group showed a high level of calorie energy malnutrition (86%) and, to a lesser extent, visceral and protein malnutrition. The liver patient group showed 67% of visceral malnutrition and lower levels of calorific energy and protein malnutrition. All the OLT candidates showed a high rate of nutritional deterioration. The greater presence of calorific energy malnutrition in the PAF I patients might be due to the neuropathic gastro-intestinal condition. The high level of malnutrition encountered suggest the need for pre-transplant nutritional intervention designed to minimise post-surgical risk.
de la Rubia
M A
MA
Servicio de Farmacia, Endocrinólogo Hospital de Elda, España.
Serrano Corredor
S
S
López Soriano
F
F
Vila Clérigues
N
N
Rivas López
F
F
San Miguel Zamora
M T
MT
D000328:Adult; D017772:Amyloid Neuropathies / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D000704:Analysis of Variance; D000886:Anthropometry; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000503:physiopathology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009748:Nutrition Disorders / Q000209:etiology / Q000503:physiopathology; D009752:Nutritional Status; D018709:Statistics, Nonparametric
Valoración del estado nutricional de los pacientes con polineuropatía amiloidótica familiar tipo I (enfermedad de Corino Andrade) candidatos a trasplante ortotópico de hígado.