title: Magnetic resonance imaging in myelodysplastic syndromes.
abstract: In this study we used magnetic resonance imaging (MRI) to examine the axial bone marrow of 11 patients with myelodysplastic syndromes (MDS). T1 weighted images showed a reduction in signal intensity in all patients. The degree of reduction in signal intensity correlated with bone marrow cellularity rather than percentage blasts or French-American-British Co-operative group (FAB) classification. T2 weighted images showed an increase in signal intensity in 10 out of 11 patients; however, reliable grading was not possible using this sequence. Both T1 and T2 weighted images indicated a homogeneous pattern of disease within the axial skeleton in MDS. We have also shown that iron deposition in multiply transfused patients is a significant factor influencing signal reduction. The results of this study suggest that MRI may have a diagnostic role in MDS but is unlikely to be of value in staging.
authors.affiliation: Haematology Department, John Radcliffe Hospital, Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Lewis
authors.forename: J S
authors.initials: JS
authors.lastname: Wainscoat
authors.forename: N R
authors.initials: NR
authors.lastname: Moore
authors.forename: S J
authors.initials: SJ
authors.lastname: Golding
mesh_terms: D000328:Adult; D000368:Aged; D000753:Anemia, Refractory / Q000473:pathology*; D000754:Anemia, Refractory, with Excess of Blasts / Q000473:pathology; D001803:Blood Transfusion; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged