title: Exogenously supplied nitric oxide influences the dilation of the capillary microvasculature in vivo.
abstract: An endogenous NO-release which exceeds the basal endogenous NO-release has a regulatory effect on capillary microvasculature in isolatedly perfused rat hearts. The basal NO-release in contrast has no effect on capillaries. The functional findings are corresponding to the endothelial distribution of NOS in coronary vessels, which displays a lack of NOS in capillary endothelium. An increase of coronary flow by exogenously administered NO-donors does not necessarily lead to a dilation of capillary microvasculature. Local differences in the release of unstable NO by SNP and GTN are responsible for variations in effects. We can conclude: NO influences the dilation of the capillary microvasculature independently of flow regulation.
authors.affiliation: Department of Anatomy, University of Cologne, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Bloch
authors.forename: D
authors.initials: D
authors.lastname: Hoever
authors.forename: D
authors.initials: D
authors.lastname: Reitze
authors.forename: L
authors.initials: L
authors.lastname: Kopalek
authors.forename: K
authors.initials: K
authors.lastname: Addicks
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects / Q000502:physiology; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008833:Microcirculation / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D009569:Nitric Oxide / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D009569:Nitric Oxide