Solid alveolar rhabdomyosarcoma with a t(2;13).
We report a child with a progressive "solid alveolar rhabdomyosarcoma" in whom analysis of tumor cells revealed a t(2;13) translocation characteristic of the classical alveolar subtype. Both subtypes of alveolar rhabdomyosarcoma are associated with a poor response to treatment and the occurrence of this translocation in both is suggestive of a common biologic origin.
Yule
S M
SM
Department of Child Health, Medical School, Newcastle upon Tyne, U.K.
Bown
N
N
Malcolm
A J
AJ
Reid
M M
MM
Pearson
A D
AD
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D002882:Chromosomes, Human, Pair 13; D002889:Chromosomes, Human, Pair 2; D003131:Combined Modality Therapy; D006801:Humans; D018232:Rhabdomyosarcoma, Alveolar / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D014178:Translocation, Genetic