title: Membrane-associated tyrosine kinases as molecular switches.
abstract: Tyrosine kinases can be associated with membranes as membrane-spanning integral membrane proteins or as intracellular peripheral membrane proteins. Both categories of tyrosine kinase transduce extracellular signals to the cytosol by switching between inactive and active states. Switching is achieved by changes in phosphorylation state and intra- and inter-molecular binding interactions. In turn, activated tyrosine kinases affect their substrates by changing their phosphorylation state and by binding them.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Cooper
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction
chemical_list: D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases