title: Clinical evaluation of a miniaturized desktop breath hydrogen analyzer.
abstract: A small desktop electrochemical H2 analyzer (EC-60-Hydrogen monitor) was compared with a stationary electrochemical H2 monitor (GMI-exhaled Hydrogen monitor).
  
  
  RESULTS
  The EC-60-H2 monitor shows a high degree of precision for repetitive (n = 10) measurements of standard hydrogen mixtures (CV 1-8%). The response time for completion of measurement is shorter than that of the GMI-exhaled H2 monitor (37 sec. vs 53 sec.; p < 0.0001), while reset times are almost identical (54 sec. vs 51 sec. n.s). In a clinical setting, breath H2-concentrations measured with the EC-60-H2 monitor and the GMI-exhaled H2 monitor were in excellent agreement with a linear correlation (Y = 1.12X + 1.022, r2 = 0.9617, n = 115). With increasing H2-concentrations the EC-60-H2 monitor required larger sample volumes for maintaining sufficient precision, and sample volumes greater than 200 ml were required with H2-concentrations > 30 ppm.
  
  
  CONCLUSIONS
  For routine gastrointestinal function testing, the EC-60-H2 monitor is an satisfactory and reliable, easy to use and inexpensive desktop breath hydrogen analyzer, whereas in patients with difficulty in cooperating (children, people with severe pulmonary insufficiency), special care has to be applied to obtain sufficiently large breath samples.
authors.affiliation: Medical University Hospital II, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.
authors.forename: L P
authors.initials: LP
authors.lastname: Duan
authors.forename: B
authors.initials: B
authors.lastname: Braden
authors.forename: T
authors.initials: T
authors.lastname: Clement
authors.forename: W F
authors.initials: WF
authors.lastname: Caspary
authors.forename: B
authors.initials: B
authors.lastname: Lembcke
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000175:diagnosis*; D001944:Breath Tests / Q000295:instrumentation*; D004563:Electrochemistry / Q000295:instrumentation; D004867:Equipment Design; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis*; D006801:Humans; D006859:Hydrogen / Q000032:analysis*; D007421:Intestine, Small / Q000382:microbiology*; D007787:Lactose Intolerance / Q000175:diagnosis*; D007789:Lactose Tolerance Test / Q000295:instrumentation*; D007792:Lactulose / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012016:Reference Values
chemical_list: D007792:Lactulose; D006859:Hydrogen