title: Apoptosis research enters the ICE age.
abstract: Recent elucidation of the structure of interleukin-1 beta-converting enzyme (ICE), a protease with sequence homology to a nematode protein associated with programmed cell death, opens a new chapter in the study of how proteases may control cellular suicide.
authors.affiliation: Department of Oncology, Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, East Hanover, NJ 07496, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Nalin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins; D020170:Caspase 1; D020169:Caspases; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D008666:Metalloendopeptidases / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D020169:Caspases; D003546:Cysteine Endopeptidases; C089223:ced-3 protein, C elegans; D020170:Caspase 1; D008666:Metalloendopeptidases; C089403:protease resembling ICE