Cadherin-dependent cell aggregation is affected by decapeptide derived from rat extracellular super-oxide dismutase.
A synthetic HAV-containing decapeptide homologous to the amino acid sequence 44R-Q53 in rat extracellular superoxide dismutase B affects cadherin-dependent cell aggregation. Cell lines, some of them transfected, expressing different types of cadherins were tested using in vitro cell aggregation and cell dissociation assays. A concentration-dependent inhibition of aggregation by the EC-SOD-derived HAV-containing peptide was detected only in N-cadherin expressing cells. These results suggest the localisation and possible protective role of EC-SOD B for cells expressing N-cadherin.
Willems
J
J
Interdisciplinary Research Center, KULAK, Kortrijk, Belgium.
Bruyneel
E
E
Noë
V
V
Slegers
H
H
Zwijsen
A
A
Mège
R M
RM
Mareel
M
M
D000595:Amino Acid Sequence; D000818:Animals; D015820:Cadherins / Q000494:pharmacology*; D002449:Cell Aggregation / Q000187:drug effects*; D006801:Humans; D007739:L Cells; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011994:Recombinant Proteins; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000494:pharmacology; D014162:Transfection
D015820:Cadherins; D010446:Peptide Fragments; D011994:Recombinant Proteins; D013482:Superoxide Dismutase