HLA-B16 antigens: sequence of the ST-16 antigen, further definition of two B38 subtypes and evidence for convergent evolution of B*3902.
The ST-16 antigenic specificity of the HLA-B locus is defined as a B39 variant of Mexican-Americans. Nucleotide sequencing of cDNA shows the ST-16 allele (B*3905) differs from B*39011 by a single substitution that substitutes tyrosine for aspartic acid at position 74 of the mature class I heavy chain. The complete coding region sequence for the common caucasoid allele encoding the B38 antigen has been determined. This B*3801 allele differs from B*3802 at two nucleotide substitutions within the Bw4 sequence motif. B*3801 and B*3802 may have been derived independently from B*39011 by conversion events with B alleles donating distinctive Bw4 motifs. A novel allele B*39022 derived from a Colombian Indian differs from the B*39021 allele of Japanese origin at two widely separated silent substitutions. Comparison of sequences for the known B16 alleles suggest that B*39021 and B*39022 were independently derived by recombination from B*39013 and B*39011 respectively.
Adams
E J
EJ
Department of Structural Biology, Stanford University, California, USA.
Martinez-Naves
E
E
Arnett
K L
KL
Little
A M
AM
Tyan
D B
DB
Parham
P
P
D000483:Alleles; D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D005075:Biological Evolution; D002461:Cell Line, Transformed; D018076:DNA, Complementary; D015235:HLA-B Antigens / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D017058:Mexican Americans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D018076:DNA, Complementary; D015235:HLA-B Antigens; C049278:HLA-B16 antigen; C042388:HLA-Bw4 antigen