Neutrophilic eccrine hidradenitis: report of two cases.
BACKGROUND
Neutrophilic eccrine hidradenitis (NEH) is an uncommon, self-limited dermatosis usually attributed to anti-cancer chemotherapy. It is characterized histologically by necrosis of the eccrine gland and neutrophilic infiltrate.


METHODS
We saw NEH in a 5-year-old boy with acute lymphoblastic leukemia and a 4-year-old girl with acute monocytic leukemia. NEH developed after the anti-leukemic chemotherapy including high dose cytarabine. The eruption was composed of vesicles, papules, and plaques.


CONCLUSIONS
Histological findings were compatible with those described in the literature. NEH in our two patients could be attributed to high doses of cytarabine.
Kanzaki
H
H
Department of Dermatology, Okayama University Medical School, Japan.
Oono
T
T
Makino
E
E
Arata
J
J
Oda
M
M
Akazai
A
A
D002675:Child, Preschool; D003561:Cytarabine / Q000009:adverse effects*; D004439:Eccrine Glands / Q000473:pathology; D005260:Female; D016575:Hidradenitis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy; D008297:Male; D009336:Necrosis; D009504:Neutrophils / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy
D003561:Cytarabine