title: In vitro susceptibility to 9 antifungal agents of 14 strains of Zygomycetes isolated from clinical specimens.
abstract: Fourteen clinical isolates of Zygomycetes were tested for their in vitro susceptibility to nine antifungal agents. Susceptibility assessment was performed using a microtiter broth dilution method. Synthetic broth with YNB and glucose was used for 5-fluorocytosine and BHI broth for all the other antimycotics. Amphotericin B exhibited the strongest activity against all isolates tested. MIC values of other two polyenes--nystatin and pimaricin--ranged within the susceptibility limits, with a little pronounced higher activity of pimaricin. The isolates of the genus Absidia and Syncephalastrum were well sensitive to all antimycotics with the exception of 5-fluorocytosine and naftifine. A very weak or zero growth inhibitory effect against all members of the genera Mucor and Rhizopus was found in azoles, 5-fluorocytosine and naftifine.
authors.affiliation: Institute of Experimental Biopharmaceutics, Joint Research Center of PRO.MED.CS Praha, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Otcenásek
authors.forename: V
authors.initials: V
authors.lastname: Buchta
mesh_terms: D000499:Allylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000187:drug effects; D009090:Mucorales / Q000187:drug effects*; D012233:Rhizopus / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D000499:Allylamine; C029178:naftifine; D005437:Flucytosine