title: Changes in mood during acute hypoglycemia in healthy participants.
abstract: Acute hypoglycemia provides a reproducible method of investigating the effect of biological changes induced during hypoglycemia on mood states. Hypoglycemia was induced twice using a hyperinsulinemic glucose clamp in 24 nondiabetic human participants; a euglycemic placebo control study was also performed. Serial changes in mood were assessed using the UWIST Mood Adjective Checklist before, during, and after 60 min of controlled hypoglycemia (2.5 mmol/l). Hypoglycemia induced a significant reduction in hedonic tone (p = .001), a significant increase in tense arousal (p < .0005), and a significant decline in energetic arousal (p = .01) in comparison with the euglycemia control study. Profound changes in mood were observed in nondiabetic participants during acute hypoglycemia, and a state called tense tiredness persisted for at least 30 min after restoration of euglycemia.
authors.affiliation: Department of Diabetes, Royal Infirmary of Edinburgh, Scotland.
authors.forename: A E
authors.initials: AE
authors.lastname: Gold
authors.forename: K M
authors.initials: KM
authors.lastname: MacLeod
authors.forename: B M
authors.initials: BM
authors.lastname: Frier
authors.forename: I J
authors.initials: IJ
authors.lastname: Deary
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D001143:Arousal / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000523:psychology; D007003:Hypoglycemia / Q000097:blood / Q000523:psychology*; D008297:Male; D010555:Personality Inventory
chemical_list: D001786:Blood Glucose