title: Differences between anti-myeloperoxidase- and anti-proteinase 3-associated renal disease.
abstract: We performed a retrospective study of the clinical features, the pattern of the pre-treatment renal function loss, the renal morphology and the outcome in 92 patients with anti-neutrophil cytoplasmic autoantibodies directed against proteinase 3 (aPR3; N = 46) or myeloperoxidase (aMPO; N = 46). Patients with aMPO had a higher median age than patients with a PR3 (63 and 56 years; P < 0.05). The mean (+/- SD) number of affected organs in the aPR3 group exceeded that of the aMPO group (3.9 +/- 1.4 and 2.2 +/- 1.1; P < 0.01). The prevalence of renal involvement did not differ between patients with aPR3 and aMPO (83% and 67%, respectively; NS). Pre-treatment renal function deteriorated significantly faster in aPR3- than in aMPO-associated renal disease. The kidney biopsies from patients with aPR3 showed a higher activity index (10.2 +/- 3.8 and 7.3 +/- 3.2; P < 0.03) and a lower chronicity index (4.5 +/- 2.6 and 7.0 +/- 3.1; P < 0.02) than biopsies from patients with aMPO. The kidney survival at two years was 73% in patients with aPR3- and 61% in patients with aMPO-associated renal disease (NS). We conclude that renal function generally deteriorates faster in aPR3- than in aMPO-associated renal disease. This goes together with more active renal lesions in patients with aPR3 and more chronic renal lesions in patients with aMPO. Despite these differences, there is no difference in outcomes between both antibody groups.
authors.affiliation: Department of Medicine and Biostatistics, Catharina Hospital, Eindhoven, The Netherlands.
authors.forename: C F
authors.initials: CF
authors.lastname: Franssen
authors.forename: R O
authors.initials: RO
authors.lastname: Gans
authors.forename: B
authors.initials: B
authors.lastname: Arends
authors.forename: C
authors.initials: C
authors.lastname: Hageluken
authors.forename: P M
authors.initials: PM
authors.lastname: ter Wee
authors.forename: P G
authors.initials: PG
authors.lastname: Gerlag
authors.forename: S J
authors.initials: SJ
authors.lastname: Hoorntje
mesh_terms: D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D053146:Myeloblastin; D009195:Peroxidase / Q000276:immunology*; D010488:Polyarteritis Nodosa / Q000276:immunology / Q000401:mortality / Q000473:pathology; D012189:Retrospective Studies; D012697:Serine Endopeptidases / Q000276:immunology*; D016019:Survival Analysis
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D009195:Peroxidase; D012697:Serine Endopeptidases; D053146:Myeloblastin