[Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats].
Experiments were carried on rats to study the preventive effects of calcium channel blockers Nitrendipine, Nifedipine and L-Arginine (L- Arginine is the physiological precursor of nitric oxide in endothelium-dependent relaxation) on chronic intermittent hypoxia induced pulmonary hypertension, on the right ventricular hypertrophy and pulmonary vascular pathologic changes. The results showed (1) Nitrendipine, Nifedipine and L-arginine played significant role in preventing chronic hypoxic pulmonary hypertension and the right ventricular hypertrophy. (2) There was no significant difference between Nitrendipine, Nifedipine and L- arginine in preventing hypoxic pulmonary hypertension (P > 0.05). (3) Nitrendipine was better than Nifedipine in reducing the hypoxic pulmonary hypertension.
Li
M R
MR
Guangzhou Institute of Respiratory Diseases.
Chen
S C
SC
Ma
G
G
D000818:Animals; D001120:Arginine / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000517:prevention & control*; D017380:Hypertrophy, Right Ventricular / Q000517:prevention & control*; D000860:Hypoxia / Q000150:complications*; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use; D009568:Nitrendipine / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001120:Arginine; D009568:Nitrendipine; D009543:Nifedipine