title: Vessel dilator is associated with survival after acute myocardial infarction.
abstract: To assess whether infarct size, ischemic area and/or survival correlates with circulating atrial natriuretic peptides (long acting sodium stimulator, vessel dilator, or atrial natriuretic factor), these peptides were measured in a canine model of acute myocardial infarction. Elevations in the circulating concentrations of atrial natriuretic factor, vessel dilator, and long acting sodium stimulator were significant (P < 0.05) within 6 min of coronary occlusion of the left anterior descending coronary artery. The percentage of ischemic myocardium ranged from 20 to 67% with a mean of 37 +/- 17%. The area of infarction ranged from 1 to 13% with the infarcted area of non-survivors being twice that of survivors. Both the ischemic and infarcted areas correlated (P < 0.05) with the circulating concentrations of these atrial natriuretic peptides. Survival correlated also with the circulating plasma concentrations of vessel dilator, atrial natriuretic factor and long acting sodium stimulator (P < 0.05). When these circulating concentrations were evaluated, however, by determining their area under their respective concentrations curves and expressing each as the log area under plasma concentration-time curve (area under the curve) per kg of weight (Y = 58.48X-23.62; r = 0.825; P = 0.0009), vessel dilator was the only atrial natriuretic peptide that correlated with survival.
authors.affiliation: Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, USA.
authors.forename: B H
authors.initials: BH
authors.lastname: Ackerman
authors.forename: R P
authors.initials: RP
authors.lastname: Wyeth
authors.forename: M E
authors.initials: ME
authors.lastname: Soulsby
authors.forename: A A
authors.initials: AA
authors.lastname: Pappas
authors.forename: D L
authors.initials: DL
authors.lastname: Vesely
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D016001:Confidence Intervals; D004285:Dogs; D006439:Hemodynamics; D016014:Linear Models; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology; D011863:Radioimmunoassay
chemical_list: D009320:Atrial Natriuretic Factor