Effect of dissolved oxygen levels on biosynthesis of aureofungin by Streptoverticillium cinnamoneum var. terricola.
Biosynthesis of aureofungin by Streptoverticillium cinnamoneum var, terricola was found to be an oxygen dependent reaction. An accelerated rate of aureofungin production, along with a better yield coefficient were obtained under conditions of enhanced aeration during fermentation. A higher oxygen transfer rate was found to stimulate aureofungin A, and suppresses aureofungin B formation.
Patankar
P V
PV
Hindustan Antibiotics Ltd., Pimpri, Pune.
Nanda
R K
RK
Naik
S R
SR
D000935:Antifungal Agents / Q000096:biosynthesis*; D003470:Culture Media; D010100:Oxygen / Q000494:pharmacology*; D011090:Polyenes / Q000378:metabolism; D013306:Streptomycetaceae / Q000187:drug effects / Q000378:metabolism*
D000935:Antifungal Agents; D003470:Culture Media; D011090:Polyenes; C030205:aureofungin B; C006651:aureofungin A; D010100:Oxygen