Photodynamic therapy of photofrin II and excimer dye laser on experimental tumors.
Photodynamic therapy (PDT) by combination of photofrin II and excimer dye laser was evaluated for its usefulness in experimental tumors. High antitumor effects of PDT on sarcoma 180 solid type were obtained when PDT was performed with laser irradiation at an energy of 50 or 100 J/cm2 (40 or 80 Hz, 4 mJ/pulse) 48 h after i.v. administration of photofrin II at a dose of 25 mg/kg. Under the same conditions, the antitumor effects of PDT on murine Lewis lung carcinoma, human fibrosarcoma HT-1080 and human bladder transitional cell carcinoma KK-47 were also observed. These results suggest that clinical application of PDT with photofrin II and excimer dye laser might be useful.
Tanaka
M
M
Department of Experimental Therapeutics, Kanazawa University, Japan.
Uchibayashi
T
T
Obata
T
T
Sasaki
T
T
D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use*; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy*; D006414:Hematoporphyrin Photoradiation / Q000379:methods*; D006801:Humans; D053685:Laser Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D012510:Sarcoma 180 / Q000188:drug therapy*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D017323:Dihematoporphyrin Ether