title: Magnetic resonance imaging of an experimental model of intracranial metastatic disease. A study of lesion detectability.
abstract: OBJECTIVE
  The detectability of brain metastases was evaluated in a rabbit model, with attention to magnetic resonance contrast dose and timing of image acquisition after injection of contrast medium.
  
  
  METHODS
  Five New Zealand white rabbits were studied at 1.5 T 6 to 7 days and 11 to 12 days after surgical implantation of an adenocarcinoma tumor nidus. T1- and T2-weighted spin-echo images (0.9 x 0.9 x 2 mm3 voxel size) were obtained before administration of contrast medium. T1-weighted images were repeated 5, 15, and 30 minutes after intravenous injection of 0.1 mmol/kg gadoteridol. At 40 minutes, a supplemental dose of 0.2 mmol/kg (0.3 mmol/kg cumulative dose) was administered, with T1-weighted images repeated at 5, 15, and 30 minutes after the second injection.
  
  
  RESULTS
  Six to 7 days after tumor implantation, lesion enhancement (percent change, with normalization to baseline and equilibrium values) was 42 +/- 9% at 5 minutes, 48 +/- 9% at 15 minutes, and 42 +/- 10% at 30 minutes after administration of 0.1 mmol/kg gadoteridol. After administration of 0.3 mmol/kg gadoteridol, lesion enhancement was 111 +/- 13% at 5 minutes, 116 +/- 8% at 15 minutes, and 100% at 30 minutes. On film review, 2 of 5 lesions were not detectable at 6 to 7 days after tumor implantation with 0.1 mmol/kg gadoteridol. Administration of 0.3 mmol/kg gadoteridol provided for lesion identification in each instance. Eleven to 12 days after tumor implantation, one lesion was not detectable with 0.1 mmol/kg gadoteridol. Administration of 0.3 mmol/kg gadoteridol again provided for lesion identification in all cases. Mean lesion enhancement increased from 39 +/- 15% to 104 +/- 10%.
  
  
  CONCLUSIONS
  The administration of 0.3 mmol/kg gadoteridol (high dose) compared with 0.1 mmol/kg gadoteridol (conventional dose) improves metastatic lesion detectability in the brain. The lesions identified only at high dose were confirmed by histopathology. Smaller lesions were not detected at a dose of 0.1 mmol/kg.
authors.affiliation: Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington 40536-0098, USA.
authors.forename: V M
authors.initials: VM
authors.lastname: Runge
authors.forename: J W
authors.initials: JW
authors.lastname: Wells
authors.forename: N M
authors.initials: NM
authors.lastname: Williams
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000556:secondary; D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D003287:Contrast Media; D005682:Gadolinium; D006571:Heterocyclic Compounds; D008279:Magnetic Resonance Imaging; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds; D011817:Rabbits; D013997:Time Factors
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium