Integrins and signal transduction pathways: the road taken.
Adhesive interactions play critical roles in directing the migration, proliferation, and differentiation of cells; aberrations in such interactions can lead to pathological disorders. These adhesive interactions, mediated by cell surface receptors that bind to ligands on adjacent cells or in the extracellular matrix, also regulate intracellular signal transduction pathways that control adhesion-induced changes in cell physiology. Though the extracellular molecular interactions involving many adhesion receptors have been well characterized, the adhesion-dependent intracellular signaling events that regulate these physiological alterations have only begun to be elucidated. This article will focus on recent advances in our understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors.
Clark
E A
EA
ARIAD Pharmaceuticals, Cambridge, MA 02139, USA.
Brugge
J S
JS
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion; D016207:Cytokines / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D016023:Integrins / Q000502:physiology*; D010770:Phosphotransferases / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D015398:Signal Transduction
D016207:Cytokines; D003598:Cytoskeletal Proteins; D016326:Extracellular Matrix Proteins; D016023:Integrins; D010770:Phosphotransferases; D017027:Protein Tyrosine Phosphatases; D019204:GTP-Binding Proteins; D002118:Calcium