Combined immunomodulation (Propionibacterium avidum KP-40) and lectin blocking (D-galactose) prevents liver tumor colonization in BALB/c-mice.
The protective effect of combined treatment (immunomodulation with Propionibacterium avidum KP-40; liver lectin blocking by D-galactose administration) on the liver colonization of RAW 117-H10 lymphosarcoma was investigated in BALB/c-mice. Both, immunomodulation with P. avidum KP-40 as well as liver lectin blocking by D-galactose treatment significantly decreased the number of liver tumor colonies in this experimental model. However, the combination of P. avidum KP-40 and D-galactose obviously proved to be superior to each monotherapy since the liver colonization by RAW 117-H 10 lymphosarcoma could be completely inhibited.
Pulverer
G
G
Institute of Medical Microbiology and Hygiene, University of Cologne, FRG.
Ko
H L
HL
Tunggal
L
L
Beuth
J
J
Jeljaszewicz
J
J
D000818:Animals; D005690:Galactose / Q000627:therapeutic use*; D007167:Immunotherapy; D037102:Lectins / Q000037:antagonists & inhibitors*; D008114:Liver Neoplasms, Experimental / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011424:Propionibacterium / Q000276:immunology*
D037102:Lectins; D005690:Galactose