Hepatic metastases from soft-tissue sarcoma.
OBJECTIVE
Hepatic metastases from soft-tissue sarcoma are evaluated to define treatment and its limitations.


METHODS
From 981 adult patients with diagnoses of soft-tissue sarcoma, 65 patients with hepatic metastases were studied.


RESULTS
An intra-abdominal primary site was present in 61 of 65 patients, with 85% high-grade leiomyosarcoma. Hepatic resection was performed in 14 patients (22%). All patients have had recurrences after hepatic resection-11 of 14 in the liver--with a median survival of 30 months. Chemotherapy resulted in partial response in three patients and no complete responses. Survival is not influenced by grade, type, primary site, disease-free interval, chemotherapy, or hepatic resection.


CONCLUSIONS
The uncommon response to conventional chemotherapy does not support its use in the treatment of hepatic metastases from soft-tissue sarcoma. Extent of disease limits the application and success of hepatic resection for soft-tissue sarcoma, and anything less than complete resection is not indicated.
Jaques
D P
DP
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Coit
D G
DG
Casper
E S
ES
Brennan
M F
MF
D000328:Adult; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology / Q000556:secondary* / Q000628:therapy; D012509:Sarcoma / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate