title: [Ineffectiveness of platelet transfusions in the course of thrombocytopenia of central origin. Work Group coordinated by ANDEM].
abstract: This study, conducted under the auspices of ANDEM, was aimed at determining the reasons for the inefficacy of platelet transfusions for thrombocytopenia of central origin, and to establish recommendations for therapy and prevention. It was based on a critical review of the literature. Three main causes of inefficacy were identified: an immunological conflict (mainly anti-HLA alloimmunization), clinical status, and the quality of platelet preparations (especially storage time). Our recommendations depend on several factors, such as the degree of urgency, the cause of platelet refractoriness, clinical status and the availability of platelet preparations. The mainstay of the recommendations is prevention, based on the quality of platelet preparations (as fresh as possible, in adequate number preferably obtained by apheresis and ABO compatible) and on the prevention of anti-HLA alloimmunization.
authors.affiliation: Centre de Transfusion Sanguine, Hôpital Henri-Mondor, Créteil.
authors.forename: F
authors.initials: F
authors.lastname: Norol
mesh_terms: D001927:Brain Diseases / Q000150:complications*; D006801:Humans; D007114:Immunization; D007518:Isoantibodies / Q000097:blood; D017713:Platelet Transfusion / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D007518:Isoantibodies
vernacular_title: Inefficacité des transfusions de plaquettes au cours des thrombopénies d'origine centrale. Groupe de Travail Coordonné par l'ANDEM.