title: High flow priapism associated with sickle cell disease.
abstract: Priapism associated with sickle cell disease is classically described as a low flow state. We report 2 cases of high flow priapism associated with sickle cell disease. High flow priapism has previously been reported almost exclusively in patients with traumatic rupture of the cavernous artery. Neither of our patients had historical or radiographic findings consistent with injury to the penile vasculature. One patient was treated unsuccessfully with intracorporeal injection of methylene blue and 1 underwent successfully bilateral pudendal artery embolization. The pathophysiological mechanism(s) responsible for the production of high flow priapism in patients with sickle cell disease is not known.
authors.affiliation: Department of Surgery (Division of Urology), University of Texas Medical School, Houston 77030, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Ramos
authors.forename: J S
authors.initials: JS
authors.lastname: Park
authors.forename: M L
authors.initials: ML
authors.lastname: Ritchey
authors.forename: G S
authors.initials: GS
authors.lastname: Benson
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D004621:Embolization, Therapeutic; D006801:Humans; D008297:Male; D010413:Penis / Q000098:blood supply*; D010656:Phenylephrine / Q000627:therapeutic use; D011317:Priapism / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D010656:Phenylephrine