title: Endothelium is a target organ of parathyroid secretions in genetic hypertensive rats.
abstract: We investigated the relationships between vascular endothelium and parathyroid function. Blood pressure (BP), circulating endothelins (ETs) and atrial natriuretic peptide (ANP), and BP responses to parathyroid hormone (PTH) and NG-nitro-L-arginine methyl ester (L-NAME) were measured in parathyroidectomized (PTx), PTx and fed a Ca2+ enriched diet (PTx-HCa) and sham SHR.22 weeks after surgery, BP was significantly decreased in PTx and PTx-HCa, plasma ETs levels were increased, whereas ANP levels were decreased. In anesthetized rats, BP increase induced by L-NAME was greater in PTx-HCa than in sham group, indicating increased endogenous nitric oxide release in hypoparathyroid rats. The hypotensive response to PTH remained unchanged. These data demonstrate that endothelium is activated in long-term hypoparathyroid SHR, reflecting an adaptative response to decreased BP.
authors.affiliation: CNRS URA 600, Fac. Pharmacie, ULP Strasbourg, France.
authors.forename: R
authors.initials: R
authors.lastname: Schleiffer
authors.forename: F
authors.initials: F
authors.lastname: Pernot
authors.forename: R
authors.initials: R
authors.lastname: Jones
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000097:blood; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000502:physiology; D010280:Parathyroid Glands / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D016232:Endothelins; D010281:Parathyroid Hormone; D009569:Nitric Oxide; D009320:Atrial Natriuretic Factor; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester