Use of urine albumin measurement as a replacement for total protein.
We have investigated the replacement of urine total protein estimations for the assessment of glomerular permeability, by the measurement of urine albumin excretion using a latex particle enhanced immunoturbidimetric assay. An initial screen was performed using Albustix to assess the sample pre-dilution necessary for immunoanalysis. A total of 167 24-hour urine samples were analysed and urine albumin concentration correlated well with that of urine total protein (r = 0.93) over the range 0-16,800 mg/l. This protocol provides a more cost effective and analytically valid assessment of glomerular permeability.
Newman
D J
DJ
Department of Clinical Biochemistry, London Hospital Medical College, England, UK.
Thakkar
H
H
Medcalf
E A
EA
Gray
M R
MR
Price
C P
CP
D000419:Albuminuria / Q000175:diagnosis / Q000652:urine*; D006801:Humans; D009391:Nephelometry and Turbidimetry; D011507:Proteinuria / Q000175:diagnosis / Q000652:urine*; D011934:Reagent Strips
D011934:Reagent Strips