Elevated levels of interleukins IL-1 beta, IL-6 and IL-8 in naturally acquired viral rhinitis.
We studied the cytokines IL(interleukin)-1 beta, IL-4, IL-6 and IL-8 in nasal lavage samples from 20 patients with naturally acquired viral rhinitis and 5 healthy controls without nasal complaints. IL-1 beta, IL-6 and IL-8 levels in lavage fluid from the viral rhinitis patients were significantly elevated when compared to control subjects. IL-4 was not measurable in any of the samples. The cytokine levels in secretions from the healthy controls remained stable intraindividually on 5 consecutive sampling days. We suggest that cytokines such as IL-1 beta, IL-6 and IL-8, but not IL-4, are involved in the pathophysiology of the common cold.
Röseler
S
S
Department of Otorhinolaryngology, Heinrich-Heine-University, Düsseldorf, Germany.
Holtappels
G
G
Wagenmann
M
M
Bachert
C
C
D000328:Adult; D016022:Case-Control Studies; D003139:Common Cold / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D015847:Interleukin-4 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis*; D016209:Interleukin-8 / Q000032:analysis*; D008297:Male; D017817:Nasal Lavage Fluid / Q000276:immunology; D012220:Rhinitis / Q000276:immunology* / Q000821:virology*
D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D015847:Interleukin-4