title: Suppurative cutaneous granulomata caused by Microascus cinereus in a patient with chronic granulomatous disease.
abstract: We describe a patient with chronic granulomatous disease who presented with erythematous papular skin lesions on the chest, back, and arm. Examination of biopsy specimens from the lesions on the arm and back showed suppurative granulomata in association with acute and chronic inflammation. Histopathologic examination of a specimen from the lesion on the arm revealed fungal elements, and cultures yielded Microascus cinereus. The patient was treated with 2.5 g of intravenous amphotericin B, and the lesions resolved. We report what is, to our knowledge, the first case of invasive disease due solely to M. cinereus.
authors.affiliation: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1886.
authors.forename: A R
authors.initials: AR
authors.lastname: Marques
authors.forename: K J
authors.initials: KJ
authors.lastname: Kwon-Chung
authors.forename: S M
authors.initials: SM
authors.lastname: Holland
authors.forename: M L
authors.initials: ML
authors.lastname: Turner
authors.forename: J I
authors.initials: JI
authors.lastname: Gallin
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D001203:Ascomycota / Q000302:isolation & purification / Q000472:pathogenicity; D002648:Child; D003881:Dermatomycoses / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D009894:Opportunistic Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology
chemical_list: D000666:Amphotericin B