title: Effects of dietary supplementation on the function of alveolar macrophages of silicosis rats, on the blastogenic response of lymphocytes and on the peroxidase activity in blood of silicosis patients.
abstract: We studied the effects of a nutrient supplemented diet on the function of alveolar macrophages of silicosis rats and on the blastogenic response of lymphocytes, glutathione peroxidase (GSH-PX) activity, and lipid peroxidase (LPO) activity in the blood of silicosis patients. The results showed that a nutrient supplemented diet increased the phagocytosis rate (p < 0.01) and index (p < 0.05) of alveolar macrophages of silicosis rats. A nutrient supplemented diet also enhanced significantly the GSH-PX activity (p < 0.001) and the blastogenic response of lymphocytes (p < 0.01), and decreased substantially the LPO content (p < 0.05) in the blood of silicosis patients. We conclude that a nutrient supplemented diet may play an important role in antilipid peroxidation, decreased free radical reaction, stabilizing cell membrane, delaying lung fibrosis, and enhancing immune functions of the body.
authors.affiliation: Institute of Environmental Prevention, Northeast Coal Company, Changchun, P.R. China.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Wang
authors.forename: X Y
authors.initials: XY
authors.lastname: Ma
authors.forename: Y B
authors.initials: YB
authors.lastname: Su
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.forename: F R
authors.initials: FR
authors.lastname: Zhang
authors.forename: H W
authors.initials: HW
authors.lastname: Qi
mesh_terms: D000818:Animals; D005527:Food, Fortified; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008213:Lymphocyte Activation / Q000187:drug effects*; D016676:Macrophages, Alveolar / Q000276:immunology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012829:Silicosis / Q000097:blood* / Q000201:enzymology / Q000276:immunology
chemical_list: D005979:Glutathione Peroxidase