title: Autoantibodies to glutamate decarboxylase in a patient with cerebellar cortical atrophy, peripheral neuropathy, and slow eye movements.
abstract: OBJECTIVE
  To study the existence of autoimmunity against the cerebellum in patients with sporadic cortical cerebellar atrophy.
  
  
  METHODS
  The presence of autoantibodies against the cerebellum in the serum and cerebrospinal fluid samples that were obtained from patients with sporadic cortical cerebellar atrophy and control patients was investigated by using immunohistochemical techniques.
  
  
  METHODS
  University hospital and research laboratory in Lyons, France.
  
  
  METHODS
  Eight patients with cortical cerebellar atrophy that was associated with or without other neurological symptoms; 350 patients with various neurological diseases; and 33 normal, healthy subjects.
  
  
  METHODS
  Serum and cerebrospinal fluid anti-cerebellar autoantibodies were investigated by using indirect immunofluorescence techniques in rat cerebellum. To characterize antigen labeled by patient's serum, we used an immunotrapping enzyme activity assay of glutamate decarboxylase.
  
  
  RESULTS
  Serum and cerebrospinal fluid samples that were taken from one patient with sporadic cortical cerebellar atrophy associated with peripheral neuropathy and slow eye movements contained anti-glutamate decarboxylase autoantibodies.
  
  
  CONCLUSIONS
  These results suggest a participation of autoimmunity in the pathogenesis of some cases of sporadic cerebellar cortical atrophy and the involvement of the cerebellar gamma-aminobutyric acid-ergic system in the pathogenesis of this disease.
authors.affiliation: Ataxia Research Center, Hôpital Neurologique, Lyons, France.
authors.forename: J
authors.initials: J
authors.lastname: Honnorat
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
authors.forename: C
authors.initials: C
authors.lastname: Thivolet
authors.forename: M
authors.initials: M
authors.lastname: Aguera
authors.forename: M F
authors.initials: MF
authors.lastname: Belin
mesh_terms: D000328:Adult; D001284:Atrophy; D001323:Autoantibodies / Q000032:analysis*; D015551:Autoimmunity; D002531:Cerebellum / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D005133:Eye Movements; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000201:enzymology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase