Periodic angioedema with eosinophilia: increased serum level of interleukin 5.
A 48-year-old man developed episodic non pitting edema and eosinophilia. Symptoms were alleviated promptly when treated with prednisolone. However, major basic protein (MBP), eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN) levels in the serum as well as the total number of eosinophils remained high. During periods of attack serum levels of interleukin-5 (IL-5) were elevated, but the levels were lowered following treatment, suggesting that IL-5 is involved in periodic angioedema with eosinophilia.
Okubo
Y
Y
First Department of Internal Medicine, School of Medicine, Shinshu University, Matsumoto.
Sato
E
E
Hossain
M
M
Ota
T
T
Yoshikawa
S
S
Sekiguchi
M
M
D000799:Angioedema / Q000097:blood / Q000150:complications*; D001798:Blood Proteins / Q000378:metabolism; D047091:Eosinophil Granule Proteins; D047208:Eosinophil-Derived Neurotoxin; D004802:Eosinophilia / Q000097:blood / Q000150:complications*; D006801:Humans; D015848:Interleukin-5 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009498:Neurotoxins / Q000097:blood; D012260:Ribonucleases
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D015848:Interleukin-5; D009498:Neurotoxins; D047208:Eosinophil-Derived Neurotoxin; D012260:Ribonucleases