title: Cutaneous B-cell lymphoma with subsequent laryngeal involvement.
abstract: Cutaneous lymphoma is uncommon and lymphomatous infiltration of the larynx, occurring either as primary disease or as a feature of multifocal disease, is rare. We report a case of cutaneous, high grade non-Hodgkin's lymphoma with isolated relapse in the larynx. The laryngeal deposit was identical to the original cutaneous lymphoma, demonstrated histologically and using the polymerase chain reaction. Complete remission of the primary lesion was attained with local radiotherapy, and a second complete remission with chemotherapy. To date, no case of primary cutaneous lymphoma with subsequent involvement of the larynx has been reported, but the association is worth documenting, since symptoms referable to the larynx are easily overlooked. They may indicate incipient embarrassment of the airway, thus requiring urgent investigation and treatment, which is generally highly effective.
authors.affiliation: Meyerstein Institute of Clinical Oncology, Middlesex Hospital, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Wells
authors.forename: A
authors.initials: A
authors.lastname: Wotherspoon
authors.forename: N G
authors.initials: NG
authors.lastname: Burnet
authors.forename: J S
authors.initials: JS
authors.lastname: Tobias
mesh_terms: D000368:Aged; D002699:Chlorambucil / Q000627:therapeutic use; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology* / Q000556:secondary; D016393:Lymphoma, B-Cell / Q000503:physiopathology* / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D011859:Radiography; D012878:Skin Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy
chemical_list: D002699:Chlorambucil