The functional role of metabotropic glutamate receptors in epileptiform activity induced by 4-aminopyridine in the rat amygdala slice.
The metabotropic glutamate receptor (mGluR) antagonist, (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG; 500 microM), was tested on intracellularly recorded epileptiform activity induced by 4-aminopyridine (4-AP) in amygdala neurons. Superfusing 4-AP (1 mM) produced interictal spiking followed by ictal bursting. MCPG prevented the progressive transition from interictal spiking to ictal bursting but affected neither induction of interictal spiking nor maintenance of ongoing ictal bursting. These data suggest that mGluRs may be involved in the induction of ictal seizure events.
Arvanov
V L
VL
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77555-1031.
Holmes
K H
KH
Keele
N B
NB
Shinnick-Gallagher
P
P
D015761:4-Aminopyridine / Q000494:pharmacology; D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*
D001565:Benzoates; D018691:Excitatory Amino Acid Antagonists; D018094:Receptors, Metabotropic Glutamate; C079694:alpha-methyl-4-carboxyphenylglycine; D015761:4-Aminopyridine; D005998:Glycine