title: Systemic effects of different perfluorochemical agents.
abstract: OBJECTIVE
  An intravitreal injection of Fluosol-DA leads to a higher alteration of the macrophage system of the retina than perfluorooctane and perfluorodecalin administered by the same route. The difference may be due to different kinds of oxidative damage caused by the three chemicals. To test the validity of this assumption, the degree of cell alteration, expressed as reduction of cytoplasmic motility, caused by these three perfluorochemicals was examined.
  
  
  METHODS
  Using the hepatic macrophage system of the rat, cell alteration was examined by magnetometry after intravenous application of various perfluorochemicals [emulsified perfluorodecalin (C10F18), perfluorooctane (C8F17Br) and Fluosol-DA (corresponding to a 20% emulsion of 70% perfluorodecalin and 30% perfluorotripropylamine, C9F21N)].
  
  
  RESULTS
  After administration of high doses, all perfluorochemicals led to cytoskeleton alteration. This alteration, expressed as retardation of the relaxation period of ferromagnetic iron oxide particles, was most pronounced after administration of Fluosol-DA.
  
  
  CONCLUSIONS
  The compromising effect of perfluorochemicals is dose dependent and differs among the three compounds tested, with Fluosol-DA showing the greatest decrease in cytoplasmic motility.
authors.affiliation: Universitäts-Augenklinik, Bonn, Germany.
authors.forename: A J
authors.initials: AJ
authors.lastname: Augustin
authors.forename: M
authors.initials: M
authors.lastname: Spitznas
authors.forename: F H
authors.initials: FH
authors.lastname: Koch
authors.forename: T
authors.initials: T
authors.lastname: Böker
authors.forename: D
authors.initials: D
authors.lastname: Meller
authors.forename: J
authors.initials: J
authors.lastname: Lutz
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004574:Electromagnetic Fields; D004655:Emulsions; D005290:Ferric Compounds; D005466:Fluorocarbons / Q000633:toxicity*; D007275:Injections, Intravenous; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004655:Emulsions; D005290:Ferric Compounds; D005466:Fluorocarbons; C000499:ferric oxide; C008805:perfluorodecalin; C073608:perfluorooctane; C050455:fluosol