Recurrent acute multifocal placoid pigment epitheliopathy in two cousins.
OBJECTIVE
To test the hypothesis that there may be inherited predisposition in acute multifocal placoid pigment epitheliopathy, HLA typing was undertaken in two cousins with recurrent disease.


CONCLUSIONS
Both cousins were shown to have HLA antigens DR2 but not B7; both antigens have been associated with this disorder previously. This finding is compatible with the concept that DR2 may be associated with an increased risk of recurrent disease.
Kim
R Y
RY
Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, London, United Kingdom.
Holz
F G
FG
Gregor
Z
Z
Bird
A C
AC
D000208:Acute Disease; D000328:Adult; D005260:Female; D015793:HLA-B7 Antigen / Q000032:analysis; D015802:HLA-DR2 Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D010375:Pedigree; D010857:Pigment Epithelium of Eye / Q000276:immunology; D012008:Recurrence; D012164:Retinal Diseases / Q000235:genetics* / Q000276:immunology
D015793:HLA-B7 Antigen; D015802:HLA-DR2 Antigen