[Serum levels of cytokines as a measure of response to stress after various types of elective gallbladder surgery].
The authors investigated the cytokine levels in patients after laparoscopic cholecystectomy (LCHE), conventional open cholecystectomy (OCHE) and complicated open cholecystectomy (KOMPL) in order to assess whether there is a relationship between cytokine levels and the general reaction of the organism, the type and extent of the operation. They did not find an increase of IL-1 or IL-2 levels in any of the patient groups. The IL-6 concentration was slightly raised only in three patients of the OCHE group three hours after surgery and this rise persisted for 24 hours. In the KOMPL group there was a more marked rise of IL-6 in 9 patients within 3 hours after surgery, persisting in 6 patients for 24 hours and in 2 patients for 48 hours. The TNF values were similar; in group OCHE they were slightly elevated in 2 patients 24 hours after operation. In the KOMPL group these values were elevated in 5 patients for 3 hours after surgery and this increase persisted in 2 for 24 hours after surgery. Based on the investigation of cytokine levels, which is a recent indicator for evaluating the reaction of the organism to stress, conclude that laparoscopic cholecystectomy is a minimal stress for the patient and is associated with a zero defence reaction of the organism, if evaluated according to serum cytokine concentrations.
Svoboda
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P
Urazová nemocnice Brno, reditel MUDr. P. Zelnícek, CSc.
Kantorová
I
I
Ochmann
J
J
Michek
J
J
D000328:Adult; D002763:Cholecystectomy / Q000009:adverse effects; D017081:Cholecystectomy, Laparoscopic; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha
Sérové hladiny cytokinů jako mĕrítko odpovĕdi organismu na zátĕz po elektivních operacích zlucníku různého typu.