Nontoxic intravitreal dose of ofloxacin for rabbit retina.
We studied the nontoxic intravitreal concentration of ofloxacin, a new quinolone antibacterial agent, by evaluating its effects on in vitro and in vivo electroretinograms (ERGs) in albino and pigmented rabbits. After perfusion with a 36 micrograms/ml solution of ofloxacin, the in vitro ERG remained unchanged. The in vivo ERG and the visually evoked potential remained unchanged 4 weeks after vitrectomy with 50 micrograms/ml ofloxacin, and the retina was within normal limits both ophthalmoscopically and histologically. Therefore, the retinal toxicity of ofloxacin is low and within safe limits at clinical dosage.
Sakai
H
H
Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa, Japan.
Mochizuki
K
K
Torisaki
M
M
Yamashita
Y
Y
Komatsu
M
M
Tanahashi
T
T
D000818:Animals; D004596:Electroretinography; D009877:Endophthalmitis / Q000188:drug therapy; D005074:Evoked Potentials, Visual / Q000502:physiology; D007267:Injections; D015242:Ofloxacin / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D014821:Vitrectomy; D014822:Vitreous Body
D015242:Ofloxacin