title: [Insulin resistance in the pathogenesis of polycystic ovarian disease (PCOD)].
abstract: In polycystic ovarian disease there is a strong association between hyperinsulinemia and hyperandrogenism but not with obesity alone. The magnitude of peripheral insulin resistance is similar to that seen in non-insulin-dependent diabetes mellitus. Mild hyperinsulinemia in PCOD patients is not impair the carbohydrate metabolism. The elimination of the cause of hyperandrogenism by bilateral oophorectomy, long-acting Gn-RH agonist or antiandrogen cyproterone acetate did not improve the associated insulin resistance. In opposition to insulin resistance in the tissues responsible for metabolism of carbohydrate, the ovary remains sensitive to the effects of pancreatic hormone. Presumably this mechanism involved the interaction with IGF-I receptors to stimulate thecal and stromal androgen production. Insulin may sensitize the stroma to the stimulatory effect of LH. In the mechanism of follicular arrest take part increased level of binding proteins for IGF-I, mainly IGFBP 2, -4 and 5 inhibit FSH and IGF-I action.
authors.affiliation: II Kliniki Ginekologii Operacyjnej Akademii Medycznej, Lublinie.
authors.forename: J
authors.initials: J
authors.lastname: Jakowicki
mesh_terms: D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications; D006946:Hyperinsulinism / Q000150:complications; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D013002:Somatomedins / Q000502:physiology
chemical_list: D013002:Somatomedins
vernacular_title: Insulinooporność w patogenezie zespołu policystycznych jajników (PCOD).