title: The genotoxicity of substituted nitrobenzenes and the quantitative structure-activity relationship studies.
abstract: The genotoxicity of 22 substituted nitrobenzenes was evaluated by the chromosome aberrations test in cultured human peripheral lymphocytes. 18 of 22 compounds exhibit genotoxic activities. A quantitative structure-activity relationship model was established to correlate the genotoxicity of substituted nitrobenzenes and the characteristics of the substituents on the benzene ring.
authors.affiliation: Department of Environmental Science and Engineering, Nanjing University, P.R. China.
authors.forename: Q
authors.initials: Q
authors.lastname: Huang
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Han
mesh_terms: D002452:Cell Count / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009154:Mutation / Q000187:drug effects* / Q000235:genetics; D009578:Nitrobenzenes / Q000737:chemistry / Q000633:toxicity*; D016273:Occupational Exposure; D012044:Regression Analysis; D013329:Structure-Activity Relationship
chemical_list: D009578:Nitrobenzenes