title: EP4-receptors and cyclic AMP in pig venous smooth muscle: evidence with agonists and the EP4-antagonist, AH22921.
authors.affiliation: Biology Division, Glaxo Research and Development Ltd, Ware, Herts, U.K.
authors.forename: R A
authors.initials: RA
authors.lastname: Coleman
authors.forename: A
authors.initials: A
authors.lastname: Mallett
authors.forename: R L
authors.initials: RL
authors.lastname: Sheldrick
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D015232:Dinoprostone / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D018078:Receptors, Prostaglandin E / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D012501:Saphenous Vein / Q000502:physiology; D013552:Swine; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014684:Venae Cavae / Q000502:physiology
chemical_list: D001713:Biphenyl Compounds; D011450:Prostaglandin Endoperoxides, Synthetic; D011453:Prostaglandins; D018078:Receptors, Prostaglandin E; D014662:Vasoconstrictor Agents; C048979:AH 22921; C016767:sulprostone; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D006632:Histamine; D000242:Cyclic AMP; D015232:Dinoprostone