Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury.
The cardio-protective mechanisms of EGb 761, an extract of Ginkgo biloba leaves, on myocardial ischemia-reperfusion injury were investigated using rabbits subjected to 30 minutes of regional cardiac ischemia and 120 min of reperfusion under anesthesia. Compared to the saline perfused group, EGb 761 treatment (10 mg/kg, injected into the coronary artery) significantly inhibited the increase in lipid peroxidation and maintained total and CuZn-SOD levels in both plasma and tissue during and at the end of reperfusion. Both the decrease in tissue type plasminogen activator (t-PA) and the increase in plasminogen activator inhibitor-1 (PAI-1) caused by ischemia-reperfusion were also significantly suppressed by EGb 761 treatment. Furthermore, the ultrastructure of the myocytes of the EGb 761 treated heart was slightly damaged after ischemia-reperfusion, while the control ischemic-reperfused hearts demonstrated severe histological damages such as swelling and vacuolization of the mitochondria. These results suggest that EGb 761 protects hearts by its antioxidant properties and by its ability to adjust fibrinolytic activity.
Shen
J G
JG
Department of Chinese Medicine, First Military Medical University, Guangzhou, China.
Zhou
D Y
DY
D000818:Animals; D000975:Antioxidants; D016166:Free Radical Scavengers / Q000494:pharmacology*; D020441:Ginkgo biloba; D008054:Lipid Peroxides / Q000032:analysis / Q000097:blood; D008297:Male; D008928:Mitochondria / Q000502:physiology; D017202:Myocardial Ischemia / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D009206:Myocardium / Q000737:chemistry / Q000166:cytology / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology*; D010958:Plasminogen / Q000493:pharmacokinetics; D017395:Plasminogen Activator Inhibitor 1 / Q000493:pharmacokinetics; D011817:Rabbits; D013482:Superoxide Dismutase / Q000032:analysis / Q000097:blood; D013997:Time Factors; D000096983:Ginkgo Extract
D000975:Antioxidants; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D010936:Plant Extracts; D010958:Plasminogen; D017395:Plasminogen Activator Inhibitor 1; D013482:Superoxide Dismutase; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract