title: Involvement of vasodilator mechanisms in arterial pressure lability after sino-aortic baroreceptor denervation in rat.
abstract: 1. To examine the regional haemodynamic basis of arterial pressure lability seen after sino-aortic baroreceptor denervation (SAD), simultaneous beat-to-beat recordings of arterial pressure and indices of regional blood flows (Doppler probes around the subdiaphragmatic and lower abdominal aortae and the superior mesenteric artery) were performed in the same conscious rats (n = 7) before, 1 and 14 days after SAD. 2. Acute SAD increased arterial pressure, decreased regional blood flows and vascular conductances, and potentiated the depressor and vasodilator effects of ganglionic blockade with trimethaphan, suggesting sympathetic overactivity. All parameters chronically returned to or near normal. 3. Both acute and chronic SAD increased the variability of arterial pressure and of regional conductances. Arterial pressure lability was characterized by a mixture of depressor and pressor events which were associated with regional vasodilatations and vasoconstrictions, respectively. This haemodynamic pattern was not affected by acute beta-adrenoceptor blockade with propranolol. 4. In conscious rats, the baroreceptor reflex acts to buffer the spontaneous variability of regional vascular conductances and thereby stabilizes arterial pressure. Sino-aortic baroreceptor denervation-induced arterial pressure lability does not depend on the level of sympathetic activation, and is determined by the relative contribution of depressor and pressor events accompanied by extensive vasodilatations and vasoconstrictions, respectively. Vasodilatations are not caused by the stimulation of vascular beta 2-adrenoceptors.
authors.affiliation: Département de Physiologie et Pharmacologie Clinique, CNRS Unité de Recherche Associée 1483, Faculté de Pharmacie, Lyon, France.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Barrès
authors.forename: C
authors.initials: C
authors.lastname: Julien
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003714:Denervation; D015171:Ganglionectomy; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011311:Pressoreceptors / Q000601:surgery*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology; D017783:Superior Cervical Ganglion / Q000601:surgery; D014294:Trimethaphan / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
chemical_list: D018343:Receptors, Adrenergic, beta-2; D014294:Trimethaphan; D011433:Propranolol; D007545:Isoproterenol