Immunization with the malaria heat shock like protein hsp70-1 enhances transmission to the mosquito.
Mosquitoes fed on mice infected with Plasmodium yoelii after an immunization with the i72 recombinant form of the heat shock protein hsp70-1 developed significantly more oocysts than mosquitoes fed on controls. This effect was due to a marked increase in the relative numbers of gametocytes during the early stages of infection. A comparison of blood-induced and sporozoite-initiated infection showed that these gametocytes were derived from merozoites released from the liver. The stimulus for increased gametocyte production is unknown but is likely to be linked with antibody-dependent cellular cytotoxicity and associated cytokine responses.
Motard
A
A
INSERM U 313 et département de parasitologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Marussig
M
M
Rénia
L
L
Baccam
D
D
Landau
I
I
Mattei
D
D
Targett
G
G
Mazier
D
D
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000913:Antibodies, Protozoan / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D000953:Antigens, Protozoan / Q000276:immunology; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology*; D007114:Immunization; D007303:Insect Vectors; D008288:Malaria / Q000635:transmission*; D017780:Malaria Vaccines / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010967:Plasmodium yoelii / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D018840:HSP70 Heat-Shock Proteins; D017780:Malaria Vaccines; D014614:Vaccines, Synthetic