[Determination of fructosamine in the early diagnosis of disorders of carbohydrate metabolism].
Blood serum fructosamine level were measured on an empty stomach in 97 normal subjects and subjects with various disorders of carbohydrate metabolism (the so-called "pre-diabetes" and changed glucose tolerance) in order to elucidate the significance of this factor as a marker of such disorders. Fructosamine concentrations were for the first time measured in children whose parents suffered from insulin-dependent or noninsulin-dependent diabetes mellitus. The content of fructosamine on an empty stomach was found to depend on the degree of carbohydrate metabolism disorders, increasing with the progress of these disorders. The findings permit a conclusion on the possibility of using fructosamine as a marker for the diagnosis of "pre-diabetes" in subjects with its levels of 2.5 to 2.99 mmol/l and of disordered glucose tolerance in those with its levels over 3 mmol/l and glucose level on an empty stomach no more than 6 mmol/l.
Gasparian
E G
EG
Nersesian
S A
SA
Volkova
E A
EA
Kriuchkova
Z V
ZV
Nassur
S
S
Kuz'mina
M M
MM
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D050260:Carbohydrate Metabolism; D003920:Diabetes Mellitus / Q000235:genetics; D019270:Fructosamine; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis*; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis*; D013997:Time Factors
D015415:Biomarkers; D006595:Hexosamines; D019270:Fructosamine
Opredelenie fruktozamina v ranneĭ diagnostike narusheniĭ uglevodnogo obmena.