[3H]paroxetine binding to platelets of patients with social phobia: comparison to patients with panic disorder and healthy volunteers.
Recent studies suggest that serotonergic functioning may be aberrant in patients with social phobia. Capacity of the serotonin (5-HT) transporter, as determined by 3H-paroxetine binding, was measured in 18 drug-free patients with generalized social phobia and compared to 15 drug-free patients with panic disorder and 23 healthy control subjects. The density (Bmax) and affinity (1/Kd) of 3H-paroxetine binding sites was similar in all three groups. To the extent that the serotonin transporter in platelets and neurons is comparable, these findings suggest that this aspect of serotonergic function is normal in patients with social phobia.
Stein
M B
MB
Department of Psychiatry, University of Manitoba, Winnipeg, Canada.
Delaney
S M
SM
Chartier
M J
MJ
Kroft
C D
CD
Hazen
A L
AL
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins / Q000097:blood; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D016584:Panic Disorder / Q000097:blood*; D017374:Paroxetine / Q000097:blood*; D010698:Phobic Disorders / Q000097:blood*; D011869:Radioligand Assay; D012016:Reference Values; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D017374:Paroxetine