A preliminary evaluation of the cognitive and motor effects of pediatric HIV infection in Zairian children.
Fourteen asymptomatic HIV-infected Zairian children under 2 years of age displayed social and motor developmental deficits on the Denver Developmental Screening Test when compared with 20 HIV-negative cohorts born to HIV-infected mothers and 16 control children. In a second study, 11 infected children over 2 years of age had sequential motor and visual-spatial memory deficits on the Kaufman Assessment Battery for Children and motor development deficits on the Early Childhood Screening Profiles. HIV infection affects central nervous system structures mediating motor and spatial memory development, even in seemingly asymptomatic children. Furthermore, maternal HIV infection compromises the labor-intensive provision of care in the African milieu and undermines global cognitive development in even uninfected children.
Boivin
M J
MJ
Department of Psychology, Spring Arbor College, Michigan 49283, USA.
Green
S D
SD
Davies
A G
AG
Giordani
B
B
Mokili
J K
JK
Cutting
W A
WA
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D015331:Cohort Studies; D003431:Cross-Cultural Comparison; D015023:Democratic Republic of the Congo; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000151:congenital / Q000175:diagnosis* / Q000523:psychology; D018023:HIV Seronegativity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007805:Language Development Disorders / Q000175:diagnosis / Q000523:psychology; D008137:Longitudinal Studies; D008297:Male; D011939:Mental Recall; D009483:Neuropsychological Tests; D011247:Pregnancy; D011596:Psychomotor Disorders / Q000175:diagnosis* / Q000523:psychology; D012919:Social Behavior; D012951:Socialization