[Molecular mechanisms of stimulation and desensitization of Sertoli cells by follicle-stimulating hormone].
Many Sertoli functions are regulated by the receptor-mediated action of follicle-stimulating hormone (FSH). The interaction of FSH with its specific cell surface receptors leads to stimulation of a number of intracellular events, including the activation of guanine nucleotide binding protein (G protein), adenylate cyclase and the cAMP-dependent protein kinase (PKA) pathway. In addition to positive regulation of cell functions, a phenomenon of refractoriness occurs after primary exposure of target cells to the hormone. Different sites of lesion have been suggested including down-regulation of FSH receptor, uncoupling of the receptor and the G protein/adenylate cyclase complex, and stimulation of nucleotide phosphodiesterases or inhibition of PKA activity. Alterations of cell responsiveness are mediated by a combination of these different mechanisms occurring over different time-scales and hormonal concentrations.
Laurent-Cadoret
V
V
INRA/CNRS, URA 1291, station de physiologie de la reproduction des mammifères domestiques, PRMD, Nouzilly, France.
Guillou
F
F
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism / Q000494:pharmacology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004361:Drug Tolerance; D005640:Follicle Stimulating Hormone / Q000494:pharmacology* / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D008297:Male; D011962:Receptors, FSH / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D012708:Sertoli Cells / Q000187:drug effects* / Q000502:physiology
D011962:Receptors, FSH; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases
Mécanismes moléculaires de stimulation et désensibilisation de la cellule de Sertoli par l'hormone folliculo-stimulante.