title: Characterization of endothelinA receptors in cerebral and peripheral arteries of the rat.
abstract: We have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [125I]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the selective endothelin ETA antagonist BQ 123. A single class of ETA receptors is located in the medial layer of peripheral and cerebral arteries, and its quantification by autoradiography allows study of their regulation and function.
authors.affiliation: Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: De Oliveira
authors.forename: M
authors.initials: M
authors.lastname: Viswanathan
authors.forename: S
authors.initials: S
authors.lastname: Capsoni
authors.forename: F M
authors.initials: FM
authors.lastname: Heemskerk
authors.forename: F M
authors.initials: FM
authors.lastname: Correa
authors.forename: J M
authors.initials: JM
authors.lastname: Saavedra
mesh_terms: D000818:Animals; D001158:Arteries / Q000737:chemistry / Q000378:metabolism*; D001345:Autoradiography; D002536:Cerebral Arteries / Q000737:chemistry / Q000378:metabolism; D016232:Endothelins / Q000032:analysis / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D011485:Protein Binding; D051381:Rats; D017207:Rats, Sprague-Dawley; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin / Q000737:chemistry / Q000502:physiology*
chemical_list: D016232:Endothelins; D007457:Iodine Radioisotopes; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin