[Effect of chloditan on the changes of activity of glutathione transferase, glutathione reductase and glutathione content in the adrenal glands and liver in rats].
The chloditan (o.p-DDD, mitotane), which causes the destruction of the human and dog adrenal cortex, on the most essential system of xenobiotic metabolism: glutathione-S-transferase--glutathione has been studied. The effect of o,p-DDD on GSH level and activity of glutathione-S-transferase and glutathione reductase which maintain the level of reduced glutathione was analyzed in the adrenal and liver tissue of rats. This species is resistant to adrenocorticolytic action of o,p-DDD. It was shown that feeding of rats weighting 200-240 g with oil solution of o,p-DDD (75 mg daily) for 3 days causes the decrease in activity of glutathione-S-transferase and content of oxidazed glutathione in the adrenals with simultaneous increase of the content of reduced glutathione. The glutathione-S-transferase and glutathione reductase activity in the liver rises under the effect of o,p-DDD, the decrease of the GSH level being observed. The revealed changes may explain the species sensitivity of animals to o,p-DDD.
Zorich
P A
PA
Tronko
N D
ND
Mikosha
A S
AS
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D005260:Female; D005978:Glutathione / Q000187:drug effects* / Q000378:metabolism; D005980:Glutathione Reductase / Q000187:drug effects* / Q000378:metabolism; D005982:Glutathione Transferase / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008939:Mitotane / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008939:Mitotane; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione
Izmenenie akrivnosti glutationtransferazy, glutationreduktazy i soderzhaniia glutationa v nadpochechnikakh i pecheni krys pri vozdeĭstvii khloditanom.