Identification of MIF as a new pituitary hormone and macrophage cytokine and its role in endotoxic shock.
The protein mediator described originally as macrophage migration inhibitory factor has been "rediscovered" to be both a novel pituitary hormone and a pro-inflammatory, macrophage-derived cytokine. MIF plays a pivotal role in the host response to endotoxic shock and appears to serve as a pituitary "stress" hormone that regulates systemic inflammatory responses.
Bucala
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Picower Institute for Medical Research, New York 11030.
D000595:Amino Acid Sequence; D000818:Animals; D016207:Cytokines / Q000502:physiology*; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis / Q000502:physiology*; D008264:Macrophages / Q000276:immunology*; D008969:Molecular Sequence Data; D010908:Pituitary Hormones, Anterior / Q000032:analysis / Q000502:physiology*; D012772:Shock, Septic / Q000276:immunology*
D016207:Cytokines; D008263:Macrophage Migration-Inhibitory Factors; D010908:Pituitary Hormones, Anterior