title: Regulation of prostanoid-synthesis in the cardiovascular system.
abstract: Thromboxane A2 and prostacyclin are the two prostanoids involved in the regulation of the vascular tone. Their release is controlled by the activity of cyclooxygenase which has made this enzyme a preferred pharmacological target. We here report on the distribution of the two isoforms of cyclooxygenase in cultured mesangial cells and on a selective inhibitor of the cytokine-inducible cyclooxygenase-2. We also comment on the structure of thromboxane and prostacyclin synthase and their regulation under physiological and pathophysiological conditions.
authors.affiliation: Faculty of Biology, University of Konstanz, FRG.
authors.forename: R M
authors.initials: RM
authors.lastname: Nüsing
authors.forename: T
authors.initials: T
authors.lastname: Klein
authors.forename: I
authors.initials: I
authors.lastname: Siegle
authors.forename: R
authors.initials: R
authors.lastname: Brugger
authors.forename: V
authors.initials: V
authors.lastname: Ullrich
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002319:Cardiovascular System / Q000201:enzymology*; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*
chemical_list: D011453:Prostaglandins; D011451:Prostaglandin-Endoperoxide Synthases