title: Sympathetically-mediated thermogenic response to food in rats.
abstract: The aim of this work was to assess the participation of the sympathetic nervous system in the thermogenic response to food in control and hyperphagic rats. Rats were fed either a control (CD) or energy dense (ED) diet. After 15 days, CD rats received a small (7 kJ) meal composed of either control or energy dense diet, while ED rats received a small meal composed of energy dense diet. The experiment was then repeated, with the exception that rats received a larger portion (35 kJ) of the test meal. The postprandial increase in oxygen consumption was measured for 30 min after the small meal and 90-180 min after the completion of the large meal. The measurements were made in saline-injected and propranolol-injected rats. ED rats exhibited hyperphagia as well as an increase of 32% in resting metabolic rate after a 16 h fast. The sympathetically-mediated postprandial increase in oxygen consumption was greater after an energy dense meal than after a control meal in CD rats, and was higher in ED rats than in CD rats fed an energy dense meal. It was concluded that the sympathetically-mediated increase in the thermogenic response to food, as well as the increase in fasting metabolic rate can help prevent obesity development in hyperphagic rats.
authors.affiliation: Department of General and Environmental Physiology, University of Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Liverini
authors.forename: S
authors.initials: S
authors.lastname: Iossa
authors.forename: L
authors.initials: L
authors.lastname: Lionetti
authors.forename: M P
authors.initials: MP
authors.lastname: Mollica
authors.forename: A
authors.initials: A
authors.lastname: Barletta
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation; D001835:Body Weight; D002149:Energy Intake; D005502:Food; D006963:Hyperphagia / Q000378:metabolism; D007700:Kinetics; D008297:Male; D010101:Oxygen Consumption; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D011433:Propranolol