title: Elevation of circulating NO: its effects on hemodynamics and vascular smooth muscle cell proliferation in rats.
abstract: Object of our study was to characterize the effects of elevated circulating NO on hemodynamics and vascular smooth muscle cell proliferation in rats. Administration of molsidomine (10, 25, 50 mg/kg, bid p.o.) was followed by pharmacodynamic effects: elevation of plasma nitrite/nitrate levels and reduction of blood pressure (25 and 50 mg/kg, bid p.o.). Under these conditions no antiproliferative activity occurred in a model of "air dried" carotid artery injury. From these results we conclude that NO does not act as an antiproliferative agent under conditions where smooth muscle cell injury predominates.
authors.affiliation: BAYER AG, Institute of Cardiovascular and Arteriosclerosis Research, Wuppertal, FRG.
authors.forename: G
authors.initials: G
authors.lastname: Hecker
authors.forename: D
authors.initials: D
authors.lastname: Denzer
authors.forename: S
authors.initials: S
authors.lastname: Wohlfeil
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000032:analysis / Q000187:drug effects; D005470:Fluorometry; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008981:Molsidomine / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D004247:DNA; D008981:Molsidomine