title: Pathophysiology of irradiated skin and breast.
abstract: The evolution, time course, and dose response of gross and histologic changes associated with the acute and late changes of the skin are noted and a composite pathophysiologic operational model given. This model focuses the selection of the observations to be "scored" to assess the tolerance and cosmetic response of the skin and breast to different dose and combined therapy studies. Skin scoring, Late effects skin, Late effects breast, Skin irradiation response, Breast radiation response, Pathophysiology of irradiated skin, Dose tolerance of skin, Dose tolerance of breast, Skin functional unit, Microvessel response to irradiation.
authors.affiliation: Department of Radiation Medicine, Loma Linda University Medical Center, CA 92354, USA.
authors.forename: J O
authors.initials: JO
authors.lastname: Archambeau
authors.forename: R
authors.initials: R
authors.lastname: Pezner
authors.forename: T
authors.initials: T
authors.lastname: Wasserman
mesh_terms: D000818:Animals; D001940:Breast / Q000033:anatomy & histology / Q000187:drug effects / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004817:Epidermis / Q000033:anatomy & histology; D006801:Humans; D015601:Injury Severity Score; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000503:physiopathology* / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects*; D012720:Severity of Illness Index; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects / Q000528:radiation effects*; D013552:Swine; D013997:Time Factors