Haemostatic abnormalities in multidrug-resistant enteric fever.
Twenty-five consecutive patients with multidrug-resistant enteric fever were evaluated and followed for haemostatic abnormalities. Twenty-one (84%) of the patients had evidence of disseminated intravascular coagulation (DIC) and 12 (48%) also had evidence of associated fibrinolysis. Clinical bleeding was observed in 3 (12%) cases, and did not bear any correlation with clotting abnormalities. Protein C activity was found to be decreased in 11 of the 15 cases with DIC, and a block in its activation, as previously postulated, could not be substantiated. DIC was reversed in most cases within 8 days of the institution of specific antibiotic therapy.
Koul
P A
PA
Department of Internal Medicine, Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Quadri
M I
MI
Wani
J I
JI
Wahid
A
A
Shaban
M
M
D000293:Adolescent; D000328:Adult; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology*; D018432:Drug Resistance, Multiple; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006487:Hemostasis; D006801:Humans; D008297:Male; D011486:Protein C / Q000378:metabolism; D014435:Typhoid Fever / Q000097:blood / Q000150:complications* / Q000188:drug therapy
D011486:Protein C