Sister chromatid exchange (SCE) studies in breast cancer patients: a follow-up study.
Sister chromatid exchanges (SCEs) were studied in 20 patients with breast cancer (stage II) before surgery, one month after surgery, and after three years as a follow-up study. Data from 50 age-matched, normal healthy females, preferably from the affected families, served as controls. In each patient, 50 well-spread metaphases were scored for SCEs. The mean values of SCEs per metaphase were 5.80, 4.69, and 5.98 in breast cancer patients before surgery, one month after surgery, and after a gap of three years as a follow-up, respectively. The one-way analysis of variance was applied and it was found that there was a highly significant difference in the frequency of sister chromatid exchanges in these patients before surgery, one month after surgical removal of cancerous tissue, and after three years as a follow-up study. The elevated level of SCEs three years after surgical removal of cancerous tissue predict the chances of development of another type of cancer.
Dhillon
V S
VS
Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.
Bhasker
R
R
Kler
R S
RS
Husain
S A
SA
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012854:Sister Chromatid Exchange