Effects of prostaglandin E1, prostaglandin E0 and SPM 206 on isolated human coronary arteries.
The effects of PGE1, PGE0 and the stable PGE1-analogue SPM 206 on human epicardial coronary arteries were studied in vitro. The tension of the isolated arterial rings was measured isometrically. After precontraction, concentration-response curves with the compounds were performed. PGE1 and SPM 206 elicited concentration-dependent relaxations which are counteracted by a contractile action in higher concentrations. In PGE0, the contractile action occurred even in lower concentrations. This contraction was antagonized by the selective thromboxane A2 antagonist SQ 29,548, resulting in an equipotent relaxation for all three compounds.
Bruch
L
L
Humboldt-Universität zu Berlin, Universitätsklinikum Charité, I. Medizinische Klinik, Germany.
Kästner
A
A
Ney
P
P
Modersohn
D
D
Baumann
G
G
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*
C093083:SPM 206; C086635:prostaglandin E0; D000527:Alprostadil