title: [Keratoconus and familial topographic corneal anomalies].
abstract: OBJECTIVE
  Computer-assisted corneal topography, allows the detection of early abnormalities, including abortive or subclinical forms of keratoconus. So, it is possible to identify affected individuals with variable degrees, in family members of patients with keratoconus, to draw pedigrees, and to specify the mode of inheritance.
  
  
  METHODS
  Computer-assisted digital videophotokeratoscope was used to map the corneas of 106 family members of 30 patients with keratoconus.
  
  
  RESULTS
  Abnormalities observed included the inferior cornea markedly steeper than the superior cornea (I-S - 0.86 +/- 0.44 D) and a marked difference between the central corneal powers of the two eyes (delta PC = 0.72 +/- 0.22 D). However, there was no statistical difference with normal individuals for central corneal power.
  
  
  CONCLUSIONS
  Pedigree analysis in these families suggests, in 50% of them, an autosomal dominant mode of inheritance. However, it is impossible to conclude for the other families, because of an insufficient number of cases.
authors.affiliation: Service Daviel (ophtalmologie), CHU Morvan, Brest.
authors.forename: D
authors.initials: D
authors.lastname: Salabert
authors.forename: B
authors.initials: B
authors.lastname: Cochener
authors.forename: F
authors.initials: F
authors.lastname: Mage
authors.forename: J
authors.initials: J
authors.lastname: Colin
mesh_terms: D000328:Adult; D003315:Cornea / Q000002:abnormalities* / Q000033:anatomy & histology; D003430:Cross-Sectional Studies; D005602:France; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007640:Keratoconus / Q000453:epidemiology / Q000235:genetics*; D009887:Ophthalmoscopy / Q000379:methods; D010375:Pedigree; D015995:Prevalence; D012016:Reference Values
vernacular_title: Kératocône et anomalies topographiques cornéennes familiales.