Induction of non-responsiveness in human allergen-specific type 2 T helper cells.
Activation of allergen-reactive human T helper (Th)2 cells in the absence of professional antigen-presenting cells, induces non-responsiveness or anergy in these cells in vitro. This induction of anergy is accompanied by phenotypic modulation and altered cytokine production. Furthermore, peptide-treated Th2 cells fail to provide B-cell help for IgE synthesis. Recent studies indicate that impaired signal transduction via the T-cell receptor may account for the lack of responsiveness to antigenic stimulation. Here, we review present knowledge on the cell biology of non-responsive or anergic Th2 cells.
Yssel
H
H
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto.
Fasler
S
S
Lamb
J
J
de Vries
J E
JE
D000485:Allergens / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D017635:Clonal Anergy / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000517:prevention & control; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction / Q000502:physiology; D018418:Th2 Cells / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology
D000485:Allergens; D011948:Receptors, Antigen, T-Cell; D014614:Vaccines, Synthetic