Effects of steroidal glycosides on blood glucose in normal and diabetic mice.
Two steroidal glycosides, PO-1 and PO-2, were tested as a new hypoglycemic drug. PO-2 showed remarkable hypoglycemic activity on i.p. injection into normal mice. PO-1 slightly lowered the blood glucose in normal mice. Furthermore, PO-1 and PO-2 exhibited significant hypoglycemic effects in streptozotocin-induced diabetic mice. However, a steroid, diosgenin, did not affect the blood glucose level in either normal or streptozocin-induced diabetic mice, indicating that the branching glucose units are essential for the biological activity.
Kato
A
A
Kobe Pharmaceutical University, Hyogo, Japan.
Miura
T
T
Fukunaga
T
T
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004144:Diosgenin / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012503:Saponins / Q000494:pharmacology*; D013150:Spirostans
D001786:Blood Glucose; D007004:Hypoglycemic Agents; C093414:PO-1; C093415:PO-2; D012503:Saponins; D013150:Spirostans; D004144:Diosgenin