Cephalexin concentrations in radicular granuloma following a single oral administration of 250- or 500-mg cephalexin.
1. Cephalexin concentrations in radicular granuloma and serum following a single oral administration of 250- or 500-mg cephalexin were measured by a paper disk method. 2. The highest concentration of cephalexin in radicular granuloma following administration of 250-mg cephalexin to nonfasting patients was observed at 2 hr, and was 1.62 micrograms/g. The mean cephalexin concentration ratio of radicular granuloma/serum at 2 hr was 0.35. 3. The highest concentrations of cephalexin in radicular granuloma following administration of 500-mg cephalexin to nonfasting and fasting patients occurred at 2 and 1.5 hr, and was 3.35 and 3.42 micrograms/g, respectively. Mean cephalexin concentration ratios of radicular granuloma/serum at 2 and 1.5 hr were 0.32 and 0.30, respectively. 4. All mean cephalexin concentrations in radicular granuloma following administration of 500-mg cephalexin to both fasting and nonfasting patients exceeded MIC for 90% (2 micrograms/ml) of clinically isolated strains of alpha-hemolytic streptococci. However, those concentrations obtained by 250-mg cephalexin did not exceed it.
Akimoto
Y
Y
Department of Oral Surgery 2, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Uda
A
A
Omata
H
H
Shibutani
J
J
Nishimura
H
H
Komiya
M
M
Kawana
T
T
Kaneko
K
K
Fujii
A
A
Kaneda
T
T
D000328:Adult; D002506:Cephalexin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005215:Fasting / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010484:Periapical Granuloma / Q000378:metabolism* / Q000601:surgery
D002506:Cephalexin