title: Hearing loss and asymmetry in major depression.
abstract: To assess patterns of hearing loss and asymmetry in major depressive disorder (MDD), pure-tone and brief-click audiometric thresholds were measured in 59 inpatients with MDD and 40 normal control subjects. For both tasks, patients had higher bilateral thresholds, with marked hearing loss for the highest pure-tone frequency. At lower frequencies, patients displayed significant asymmetry, with poorer hearing in the left ear. After ECT, patients maintained the bilateral hearing losses; however, the baseline asymmetry resolved. These findings suggest that bilateral hearing loss may be a stable characteristic in severe depression. Poorer left ear pure-tone hearing may be present during the depressed state. The baseline asymmetry in audiometric deficits suggests right-hemisphere dysfunction in severe MDD.
authors.affiliation: Department of Biological Psychiatry, New York State Psychiatric Institute, New York, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Yovell
authors.forename: H A
authors.initials: HA
authors.lastname: Sackeim
authors.forename: D G
authors.initials: DG
authors.lastname: Epstein
authors.forename: J
authors.initials: J
authors.lastname: Prudic
authors.forename: D P
authors.initials: DP
authors.lastname: Devanand
authors.forename: M C
authors.initials: MC
authors.lastname: McElhiney
authors.forename: J M
authors.initials: JM
authors.lastname: Settembrino
authors.forename: G E
authors.initials: GE
authors.lastname: Bruder
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D003866:Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006311:Hearing Disorders / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged