title: Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11.
abstract: Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family. Indeed, it is involved in signal transduction of interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. In a previous report, IL6ST was assigned to chromosomes 5 and 17. Here we specify the chromosomal sublocalization of IL6ST and show that the sequence detected on 17p11 corresponds, in fact, to a nontranscribed pseudogene, whereas the active gene is located at chromosome band 5q11.
authors.affiliation: Institut de Génétique Moléculaire de Montpellier, CNRS UMR 9942, France.
authors.forename: C
authors.initials: C
authors.lastname: Rodriguez
authors.forename: J
authors.initials: J
authors.lastname: Grosgeorge
authors.forename: V C
authors.initials: VC
authors.lastname: Nguyen
authors.forename: P
authors.initials: P
authors.lastname: Gaudray
authors.forename: C
authors.initials: C
authors.lastname: Theillet
mesh_terms: D015703:Antigens, CD; D001483:Base Sequence; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D050822:Cytokine Receptor gp130; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D011544:Pseudogenes / Q000235:genetics*
chemical_list: D015703:Antigens, CD; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130