[Effect of intracerebral administration of somatostatin and neurotensin on posture and movement disorders].
Experiments were performed on male Wistar rats to study posture-movement disorders after intracerebroventricular, intraamygdalar, intrahippocampal and intranigral (pars reticulata) injections of somatostatin and neurotensin. Development of movement disturbances characterized by changes in the posture-movement syndrome was observed after somatostatin and neurotensin administration. Manifestation of movement disorders, their duration and the posture-movement syndrome structure depended on the structure to which neuropeptides were injected as well as on the neuropeptides themselves. Prolonged changes characterized by appearance of the so called "Sphinx" posture in animals developed after somatostatin intranigral administration. The obtained data permit concluding that somatostatin and neurotensin may have pathogenic significance in cataleptic syndrome development.
Shandra
O A
OA
Hodlevskyĭ
L S
LS
Panenko
A V
AV
Vastíanov
R S
RS
Oliĭnyk
A A
AA
D000818:Animals; D001921:Brain / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D007267:Injections; D008297:Male; D009496:Neurotensin / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000633:toxicity*
D009496:Neurotensin; D013004:Somatostatin
Pozo-rukhovi porushennia pry vnytrishnómozkovykh vvedenniakh somatostatyny ta neĭrotenzynu.