The acute effect of ioversol on kidney function: role of endothelin.
The effect of ioversol, a non-ionic monomer with high hydrophilicity, on renal function was studied using the isolated perfused rat kidney (IPRK). The involvement of endothelin in the renal effect of ioversol was established pharmacologically using the selective endothelin ETA receptor antagonist BQ123. Ioversol 20 mgI/ml produced a sustained fall in both renal perfusate flow (RPF) and the glomerular filtration rate (GFR) together with a fall in sodium reabsorption (FRNa) and increase in urine flow (n = 6). In the presence of BQ123 (10 microM), the effect of ioversol 20 mgI/ml on GFR was completely abolished and the fall in RPF and FRNa markedly reduced (n = 6). These results suggest that effect of ioversol on renal haemodynamics in the IPRK is mediated by endothelin. Ioversol produced a significantly smaller decrease in GFR than iopromide, a contrast media with similar osmolality but lower hydrophilicity, when compared to a previous study using an identical experimental technique. Increased hydrophilicity may therefore present an advantage for ioversol, reducing its effects on renal function.
Oldroyd
S D
SD
Sheffield Kidney Institute, Northern General Hospital, NHS Trust, UK.
Haylor
J L
JL
Morcos
S K
SK
D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000502:physiology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000009:adverse effects*
D003287:Contrast Media; D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D010456:Peptides, Cyclic; D014283:Triiodobenzoic Acids; D007472:Iohexol; C038192:iopromide; C054871:ioversol; C072247:cyclo(Trp-Asp-Pro-Val-Leu)