title: Moclobemide and nortriptyline in elderly depressed patients. A randomized, multicentre trial against placebo.
abstract: Moclobemide and nortriptyline were compared with placebo in a double-blind randomized multinational (Canada, Denmark and UK) trial comprising 109 patients of > 60 years of age with major depression (DSM-III-R). Patients were randomized to 7 weeks of treatment with doses of 400 mg/day moclobemide, 75 mg/day nortriptyline or placebo. It was necessary to adjust nortriptyline dosage in < 20% of patients to maintain serum levels within the postulated therapeutic window of 50-170 ng/ml. At end of treatment, the remission rates were 23% for moclobemide, 33% for nortriptyline and 11% for placebo. Anticholinergic and orthostatic events occurred more often with patients on nortriptyline than either moclobemide or placebo.
authors.affiliation: Douglas Hospital Research Centre, Verdun, Que., Canada.
authors.forename: N P
authors.initials: NP
authors.lastname: Nair
authors.forename: M
authors.initials: M
authors.lastname: Amin
authors.forename: P
authors.initials: P
authors.lastname: Holm
authors.forename: C
authors.initials: C
authors.lastname: Katona
authors.forename: N
authors.initials: N
authors.lastname: Klitgaard
authors.forename: N M
authors.initials: NM
authors.lastname: Ng Ying Kin
authors.forename: P
authors.initials: P
authors.lastname: Kragh-Sørensen
authors.forename: H
authors.initials: H
authors.lastname: Kühn
authors.forename: C A
authors.initials: CA
authors.lastname: Leek
authors.forename: K B
authors.initials: KB
authors.lastname: Stage
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001549:Benzamides / Q000008:administration & dosage* / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008875:Middle Aged; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D009661:Nortriptyline / Q000008:administration & dosage* / Q000009:adverse effects; D010552:Personality Assessment
chemical_list: D000928:Antidepressive Agents; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D009661:Nortriptyline; D020912:Moclobemide