title: [Hypotensive action of 0.5% carteolol versus 0.1% timolol in patients with intraocular hypertension].
abstract: OBJECTIVE
  The aim of the study was to compare 2 beta-blocker eye drops at a low concentration: 0.5% carteolol and 0.1% timolol.
  
  
  METHODS
  The study was designed as a random-order, double-blinded comparison of 2 parallel treatment groups. Fifty patients with early primary open angle glaucoma or high intraocular pressure were included. The treatment lasted 4 weeks, on the basis of 1 drop twice daily. Diurnal I.O.P. curve was assessed with 4 measurements from 8.30 a.m. to 4.30 p.m. before and after treatment. The 8.30 a.m. measure of the final assessment of I.O.P. curve was established prior to morning medication. The mean values of the 4 measures were compared.
  
  
  RESULTS
  Both treatments reduced IOP by a comparable amount: 4.25 +/- 1.2 mmHg (mean +/- SD) for carteolol and 4.69 +/- 1.9 mmHg for timolol. The decrease of IOP was found at every time of assessment, without any significant difference between treatments. Both eye drops were very well tolerated.
  
  
  CONCLUSIONS
  The results of this study show that the new beta-blocker eye drop solution 0.5% carteolol is effective for initial management of high intraocular pressure.
authors.affiliation: Laboratoire Chauvin, Montpellier.
authors.forename: C
authors.initials: C
authors.lastname: Allaire
authors.forename: C
authors.initials: C
authors.lastname: Trinquand
authors.forename: J P
authors.initials: JP
authors.lastname: Nordmann
authors.forename: J C
authors.initials: JC
authors.lastname: Dascotte
authors.forename: J L
authors.initials: JL
authors.lastname: George
authors.forename: P
authors.initials: P
authors.lastname: Lesure
authors.forename: J F
authors.initials: JF
authors.lastname: Rouland
authors.forename: L
authors.initials: L
authors.lastname: Khaitrine
authors.forename: D
authors.initials: D
authors.lastname: Sirbat
mesh_terms: D000328:Adult; D002354:Carteolol / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy*; D011446:Prospective Studies; D013999:Timolol / Q000627:therapeutic use*
chemical_list: D013999:Timolol; D002354:Carteolol
vernacular_title: Action hypotensive du cartéolol 0.5% versus timolol 0.1% chez les patients porteurs d'une hypertonie intraoculaire.