title: Liver glucokinase: decreased activity in patients with type II diabetes.
abstract: Because of the demonstration of a genetic linkage between glucokinase and Type II diabetes, and the central role of glucokinase on glucose metabolism, we studied glucokinase activity in the liver of patients with and without Type II diabetes. Glucokinase activity was decreased by about 50% in obese subjects with diabetes (n = 12) compared with (p < 0.01) lean controls (n = 9) and (p < 0.05) obese controls (n = 10). There was no difference between lean and obese controls. Fifty percent of subjects with diabetes had lower liver glucokinase activity than the lowest value of the controls. These data further support the important role that glucokinase plays in the pathogenesis of Type II diabetes.
authors.affiliation: Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Caro
authors.forename: S
authors.initials: S
authors.lastname: Triester
authors.forename: V K
authors.initials: VK
authors.lastname: Patel
authors.forename: E B
authors.initials: EB
authors.lastname: Tapscott
authors.forename: N L
authors.initials: NL
authors.lastname: Frazier
authors.forename: G L
authors.initials: GL
authors.lastname: Dohm
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D005260:Female; D005941:Glucokinase / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D005941:Glucokinase