[Interaction of DNA with actinocyl-bis-thiazole].
The DNA complexes with actinocyl-bis-bithiazole have been investigated by spectrophotometry, viscometry and flow birefringence. It was estimated, that at low degrees of binding (r < or = 0.07) this compound binds to DNA by bisintercalation via bithiazole groups located in positions 1 and 9 of the phenoxazone chromophore. The phenoxazone moiety plays in this case the role of a link connecting two intercalating fragments. As r increases, external groove binding becomes the second type of complex formation.
Krivtsova
M A
MA
Moroshkina
E B
EB
Gliben
E N
EN
D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry; D013057:Spectrum Analysis; D013844:Thiazoles / Q000737:chemistry*; D014783:Viscosity
D007364:Intercalating Agents; D013844:Thiazoles; C093229:actinocyl-bis-bithiazole; D004247:DNA
Vzaimodeĭstvie DNK s aktinoatsil-bis-bitiazolom.