Preventative policies in transfusion associated graft versus host disease in the treatment of cancer.
Experience of transfusion associated graft versus host disease (TA-GvHD) and current preventative policy in 22 UK children's cancer centres was established by questionnaire. Cellular blood products were irradiated in all centres during bone marrow transplantation, but there was no consensus for children receiving standard chemotherapy. Irradiation dose varied from 1500-5000 cGy and was below 2500 cGy in 12 units. Five cases of TA-GvHD were identified; all five children died.
Webb
D K
DK
Department of Paediatric Haematology and Oncology, Llandough Hospital, Penarth, South Glamorgan.
D002173:Cancer Care Facilities; D002648:Child; D002675:Child, Preschool; D006086:Graft vs Host Disease / Q000517:prevention & control*; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D012307:Risk Factors; D065227:Transfusion Reaction