Thrombogenicity of ionic and nonionic contrast media tested in a laser induced rat thrombosis model.
Contrast media are used as substances for visualization of vascular system. But, their administration is often associated with thromboembolic complications. The purpose of this study is to evaluate the thrombogenic action of ionic and non-ionic contrast media on thrombus formation. The experimental destruction of endothelial cells by Laser injury leads to thrombus and emboli formation. Two ionic and two non-ionic contrast media were injected intravenously via penis vein and tested at various dosages (1.0 and 2.5 ml/kg) 5, 30, 45 and 65 minutes after injection. The administration of these contrast media decreases the number of Laser injuries required to induce thrombus formation, increases the number of emboli which detached from thrombus and prolongs duration of embolization (p < or = 0.05). These experimental results suggest that ionic and non-ionic contrast media induce thrombogenic effects. This thrombogenicity was the greatest for non-ionic contrast media. It was observed the decrease of the white cells, red cells and platelets.
Aguejouf
O
O
Laboratoire d'Hématologie, Bordeaux, France.
Doutremepuich
F
F
Azougagh Oualane
F
F
Doutremepuich
C
C
D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000293:injuries; D001772:Blood Cell Count / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003287:Contrast Media / Q000737:chemistry / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000293:injuries; D007275:Injections, Intravenous; D007472:Iohexol / Q000633:toxicity*; D007479:Iopamidol / Q000633:toxicity*; D007485:Ioxaglic Acid / Q000009:adverse effects*; D007834:Lasers / Q000009:adverse effects; D008297:Male; D008833:Microcirculation; D010413:Penis / Q000098:blood supply; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013923:Thromboembolism / Q000139:chemically induced / Q000209:etiology*; D014699:Venules / Q000187:drug effects / Q000293:injuries
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; D007479:Iopamidol; D007485:Ioxaglic Acid