title: Effects of alkaloids extracted from the stem bark of Hunteria zeylanica on acute inflammation in experimental animals.
abstract: The effects of crude alkaloids extracted from the stem bark of Hunteria zeylanica GARD. (H. zeylanica) on acute inflammatory responses such as carrageenin-induced paw edema in rats and croton oil- and arachidonic acid-induced ear edema in mice were investigated. Oral administration of H. zeylanica alkaloid extract (200-400 mg/kg) significantly suppressed the paw swelling induced by carrageenin. In the croton oil-induced ear edema, topically applied H. zeylanica alkaloid extract, at doses of 200 and 400 mg/ml, also significantly reduced ear edema. Moreover, the extract (50-200 mg/kg, p.o.) reduced in a dose-dependent manner the ear swelling induced by topically applied arachidonic acid (2 mg/ear). These results suggest that the inhibitory effects of H. zeylanica alkaloid extract on acute edema formation are partly due to inhibition of 5-lipoxygenase and cyclooxygenase activity.
authors.affiliation: Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Reanmongkol
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Subhadhirasakul
authors.forename: H
authors.initials: H
authors.lastname: Takayama
authors.forename: S
authors.initials: S
authors.lastname: Sakai
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D016718:Arachidonic Acid; D002351:Carrageenan; D003436:Croton Oil; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005528:Foot / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D016718:Arachidonic Acid; D003436:Croton Oil; D002351:Carrageenan