title: Hyperintense disks on T1-weighted MR images: correlation with calcification.
abstract: OBJECTIVE
  To determine if calcification in the intervertebral disk is associated with hyperintensity on T1-weighted spin-echo magnetic resonance (MR) images.
  
  
  METHODS
  Sagittal T1-weighted MR images that showed one or more hyperintense intervertebral disks and correlative computed tomographic (CT) scans, plain radiographs, or both, were obtained in 11 patients retrospectively and in 43 patients prospectively. Six patients underwent MR imaging with a fat-suppression technique. Histologic analysis of two disks was performed.
  
  
  RESULTS
  Absence of calcification was associated with disks that were isointense relative to normal disks (P < .001), mild to moderate calcification was associated with hyperintense disks (P < .001 and P = .004 [two readers]), and both mild to moderate and marked calcifications were associated with hypointense disks (P < .001). Fat suppression resulted in a decrease in hyperintense signal in two patients.
  
  
  CONCLUSIONS
  The results indicate that hyperintensity is associated with calcification. In the absence of clinical findings that suggest other causes, hyperintense disks are suggestive of degenerative disk disease.
authors.affiliation: Department of Radiology, Cleveland Clinic Foundation, Ohio 44106, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Bangert
authors.forename: M T
authors.initials: MT
authors.lastname: Modic
authors.forename: J S
authors.initials: JS
authors.lastname: Ross
authors.forename: N A
authors.initials: NA
authors.lastname: Obuchowski
authors.forename: J
authors.initials: J
authors.lastname: Perl
authors.forename: P M
authors.initials: PM
authors.lastname: Ruggieri
authors.forename: T J
authors.initials: TJ
authors.lastname: Masaryk
mesh_terms: D000328:Adult; D000368:Aged; D002114:Calcinosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000000981:diagnostic imaging / Q000473:pathology*; D007405:Intervertebral Disc Displacement / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D013122:Spinal Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed