Effect of Helicobacter pylori on dbc-AMP stimulated acid secretion by human parietal cells.
This study examines the effect of different H.p. strains (A-D) on dbc-AMP stimulated acid secretion by human parietal cells in vitro. H.p. strains A and D reduced acid secretion dose-dependently between 20 and 80%. In contrast, H.p. strains B and C had little or no effect. We conclude that H.p. strains vary in their ability to suppress acid secretion, and that the site of inhibition lies beyond the c-AMP level, possibly involving the K+H(+)-ATPase of the parietal cell. Interference with acid secretion may facilitate H.p. colonization of the stomach and may prove to be an important pathogenetic factor.
Jablonowski
H
H
Ruhr University, Bochum, Germany.
Hengels
K J
KJ
Krämer
N
N
Geis
G
G
Opferkuch
W
W
Strohmeyer
G
G
D000632:Aminopyrine / Q000494:pharmacology; D001706:Biopsy; D016123:Campylobacter jejuni / Q000254:growth & development; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D002299:Cardia / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D015169:Colony Count, Microbial; D000242:Cyclic AMP / Q000378:metabolism*; D005744:Gastric Acid / Q000378:metabolism*; D016480:Helicobacter pylori / Q000254:growth & development; D006801:Humans; D009853:Omeprazole / Q000494:pharmacology; D010295:Parietal Cells, Gastric / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology
D002250:Carbon Radioisotopes; D000632:Aminopyrine; D000242:Cyclic AMP; D009853:Omeprazole