title: [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment.
abstract: BACKGROUND
  We used [18F]FDG and PET in patients with obsessive-compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors.
  
  
  METHODS
  In 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls.
  
  
  RESULTS
  rCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive-compulsive symptoms on the Y-BOC scale (t = 3.59, P < 0.01) was associated with a significant bilateral decrease of metabolism in the whole cingulate cortex (P < 0.001). Clinical and metabolic data were significantly intercorrelated (Kendall's tau = 0.65; P < 0.01).
  
  
  CONCLUSIONS
  These findings indicate that OCD is associated with functional hyperactivity of a selected neuronal network and that treatment to reduce symptoms may have a selective neuromodulatory effect on cingulate cortex.
authors.affiliation: Istituto di Neuroscienze and Bioimmagini CNR. c/o H San Raffaele, Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Perani
authors.forename: C
authors.initials: C
authors.lastname: Colombo
authors.forename: S
authors.initials: S
authors.lastname: Bressi
authors.forename: A
authors.initials: A
authors.lastname: Bonfanti
authors.forename: F
authors.initials: F
authors.lastname: Grassi
authors.forename: S
authors.initials: S
authors.lastname: Scarone
authors.forename: L
authors.initials: L
authors.lastname: Bellodi
authors.forename: E
authors.initials: E
authors.lastname: Smeraldi
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000378:metabolism; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism*; D011699:Putamen / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D013788:Thalamus / Q000378:metabolism; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors