Endocrine and metabolic characteristics of polyoma large T transgenic mice that develop ACTH-producing pituitary tumors.
The authors have analyzed several endocrine and metabolic parameters in polyoma large T transgenic mice (PyLT-1) that develop adrenocorticotropic hormone (ACTH)-immunoreactive pituitary tumors and in nontransgenic mice with tumor transplants. All clinically ill PyLT-1 mice (13 to 16 months of age) had pituitary macroadenomas and elevated plasma ACTH levels. Compared to PyLT-1 transgenic mice, the ACTH plasma concentrations in immunocompetent mice with transplant tumors were markedly raised. In these animals, a secondary effect of hypercorticotropism was documented by a moderate hyperglycemia. Furthermore, mice with transplant tumors had a pathological weight increase from the time the tumor was palpable. The present study supports and extends the authors' previous morphological documentation of the similarity between the ACTH-producing tumors in this mouse model and human Cushing's disease.
Helseth
A
A
Department of Biology, University of North Carolina at Chapel Hill, USA.
Haug
E
E
Nesland
J M
JM
Siegal
G P
GP
Fodstad
O
O
Bautch
V L
VL
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002455:Cell Division; D003480:Cushing Syndrome / Q000503:physiopathology*; D003593:Cytoplasm / Q000737:chemistry; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic / Q000097:blood / Q000378:metabolism*; D009368:Neoplasm Transplantation; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014556:Urine
D001786:Blood Glucose; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D000324:Adrenocorticotropic Hormone