[The effect of periodontal cytomedin on free-radical lipid oxidation and on antiaggregation activity in the periodontium in chronic stress].
Effects of polypeptide bioregulators isolated from periodontal tissue on free-radical oxidation of lipids and the microcirculatory hemostasis during the development of chronic stress were under study. Increased reactions of lipid free-radical oxidation and blood hydrocortisone levels, denudation of dental necks were observed in animals during stress, which was explained by disordered reaction of microcirculatory hemostasis assessed from the antiaggregation activity of the periodontium. Administration of a polypeptide bioregulator led to a reduction of free-radical oxidation of lipids, to an increase in the activities of antioxidative enzymes, and hence, to a reduction of the injury to the cellular structures of the periodontium due to decrease of disorders of the microcirculatory hemostasis and ischemia in it.
Silenko
Iu I
IuI
Mishchenko
V P
VP
Tokar'
D L
DL
Khavinson
V Kh
VKh
Popsuĭko
G I
GI
D000818:Animals; D002908:Chronic Disease; D005609:Free Radicals; D050356:Lipid Metabolism; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D010519:Periodontium / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000378:metabolism; D013312:Stress, Physiological / Q000150:complications / Q000378:metabolism*
D005609:Free Radicals; D010455:Peptides; C053892:cytomedins
Vliianie tsitomedina parodonta na svobodnoradikal'noe okislenie (SRO) lipidov i antiagregatsionnuiu aktivnost' v nem pri khronicheskom stresse.