Increased susceptibility to audiogenic seizures following withdrawal of progesterone.
This investigation was performed to verify a previous hypothesis which correlates the catamenial seizures with the stoppage of progesterone secretion. White rats from a Wistar strain were tested with an electric bell. Thirty-five animals refractory to the acoustic stimulus were selected for the experiment. Each animal received 9 daily injections with progesterone, 5 mgr/day. The animals were tested with the acoustic stimulus after the 5th and the 9th injections, 24 hours after the administration of the last dose. Audiogenic seizures were obtained in 29.4% of the rats tested after 5 injections and in 40.0% of the rats tested after the 9th injection. The increased seizure susceptibility lasted 3-8 days after the hormone withdrawal. In conclusion, the withdrawal of high doses of progesterone exerts a seizure-activating effect.
Voiculescu
V
V
Institute of Neurology and Psychiatry, Bucharest, Romania.
Haţegan
D
D
Manole
E
E
Ulmeanu
A
A
D000161:Acoustic Stimulation; D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D008297:Male; D011374:Progesterone / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D012640:Seizures / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000150:complications*; D013997:Time Factors
D011374:Progesterone