title: Cowden syndrome (multiple hamartoma syndrome).
abstract: Cowden syndrome (multiple hamartoma syndrome) is characterized by multiple facial papules, gingival papillomas, acral keratoses, and other hamartomatous lesions. There is a high incidence of breast and thyroid carcinoma. Recognition of this syndrome may lead to the early diagnosis of cancer.
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Mallory
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D002648:Child; D005153:Facial Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D005887:Gingival Neoplasms / Q000235:genetics / Q000473:pathology; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007642:Keratosis / Q000235:genetics / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology; D010212:Papilloma / Q000235:genetics / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology