title: Effect of peri-operative diltiazem on myocardial ischaemia and function in patients receiving mammary artery grafts.
abstract: A prospective, randomized study was performed with 66 patients undergoing elective coronary bypass surgery involving internal mammary artery (IMA) grafts to the left anterior descending artery (LAD). Patients received a continuous peri-operative infusion of either diltiazem (0.1 mg.kg-1 h-1, n = 32) or nitroglycerin (1 microgram.kg-1 min-1, n = 34) for 24 h. The aim of this study was to define the effect of the calcium channel blocker diltiazem on peri-operative ischaemia, arrhythmias and myocardial function in patients receiving arterial bypass grafts by preventing transient vasospasm. The study patients did not differ with respect to pre-operative, operative and haemodynamic data. Patients treated with diltiazem had lower numbers of ventricular premature beats/hour (8.1 +/- 7.8 vs 20.5 +/- 11.2; P < 0.05). The anti-ischaemic efficacy of peri-operative diltiazem in patients receiving IMA grafts significantly reduced the incidence and duration of transient ischaemic events (0 vs 5). Additionally, patients receiving IMA grafts and diltiazem showed significantly lower peak levels of ischaemia-sensitive laboratory parameters, as compared to IMA graft patients receiving only nitroglycerin: CK-MB: 17.3 +/- 7.7 vs 23.5 +/- 11.0, (P < 0.05); MB-M: 29.4 +/- 14.7 vs 43.1 +/- 27.4, (P < 0.05); troponin-T: 0.88 +/- 0.6 vs 1.41 +/- 0.9, (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiovascular Surgery, University of Freiburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hannes
authors.forename: R
authors.initials: R
authors.lastname: Seitelberger
authors.forename: M
authors.initials: M
authors.lastname: Christoph
authors.forename: M
authors.initials: M
authors.lastname: Keilich
authors.forename: C
authors.initials: C
authors.lastname: Kulinna
authors.forename: C
authors.initials: C
authors.lastname: Holubarsch
authors.forename: R
authors.initials: R
authors.lastname: Fasol
mesh_terms: D004110:Diltiazem / Q000627:therapeutic use*; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007387:Internal Mammary-Coronary Artery Anastomosis; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D011446:Prospective Studies
chemical_list: D004110:Diltiazem