[Circulatory arrest after splanchnic neurolysis with phenol in unresectable cancer of the pancreas].
One of the treatments for pain in patients with unresectable pancreatic cancer is chemical splanchnicectomy by phenol. We report two cases of severe cardiac arrhythmia followed by circulatory arrest, during intraoperative chemical splanchnicectomy. The cardiac toxicity of phenol is known in plastic surgery (face peeling). The reasons for this toxicity are not well known. We recommend that phenol be replaced by alcohol during chemical splanchnicectomy, because of its safety.
Lalanne
B
B
Service de Chirurgie Générale et Digestive, Hôpital Rothschild, Paris.
Baubion
O
O
Sezeur
A
A
Tricot
C
C
Gaudy
J H
JH
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006323:Heart Arrest / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control*; D010190:Pancreatic Neoplasms / Q000601:surgery*; D010636:Phenols / Q000008:administration & dosage / Q000009:adverse effects*; D013153:Splanchnic Nerves / Q000601:surgery*; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy
D010636:Phenols; D008012:Lidocaine
Arrêt circulatoire après neurolyse splanchnique au phénol pour cancer du pancréas non reséquable.