title: The effect of midazolam premedication on implicit memory activation during alfentanil-nitrous oxide anaesthesia.
abstract: Eighty-three patients were given midazolam 0.1 mg.kg-1 by intramuscular injection as premedication before general anaesthesia with alfentanil-nitrous oxide. During anaesthesia patients were presented (through headphones) with either statements about common facts of some years ago (group A) (n = 43) or new verbal associations, e.g. names of fictitious, nonfamous people (group B) (n = 40). In a previous study with the same anaesthetic technique, but without premedication there was significant activation of implicit memory (p < 0.001). In this study we found no explicit or implicit memory for the auditory information presented during anaesthesia. Midazolam premedication can prevent implicit memory activation during alfentanil-nitrous oxide anaesthesia.
authors.affiliation: Department of Anaesthesiology, University Hospital of Leiden, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: De Roode
authors.forename: M
authors.initials: M
authors.lastname: Jelicic
authors.forename: B
authors.initials: B
authors.lastname: Bonke
authors.forename: J G
authors.initials: JG
authors.lastname: Bovill
mesh_terms: D000328:Adult; D015760:Alfentanil; D000768:Anesthesia, General; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007432:Intraoperative Period; D008297:Male; D008568:Memory / Q000187:drug effects*; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D009609:Nitrous Oxide; D011229:Preanesthetic Medication
chemical_list: D015760:Alfentanil; D009609:Nitrous Oxide; D008874:Midazolam