[Studies of novel 1,4-dihydropyridine Ca antagonist CS-905. I. Measurement of partition coefficient (log P) by high performance liquid chromatography (HPLC)].
A new 1,4-dihydropyridine derivative, CS-905, currently under development as a Ca antagonist, showed a gradual onset and long duration in its antihypertensive effect upon single oral administration. The partition coefficient for CS-905 was measured along with 11 known dihydropyridine Ca antagonists by the HPLC method to clarify its mode of action. The log PHPLC for CS-905 was, 5.18, almost the same as that of manidipine and this value is the highest among the measured drugs. Its pharmacokinetic profile in SHR was also discussed.
Masumoto
K
K
Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, UBE Industries, Ltd., Yamaguchi, Japan.
Takeyasu
A
A
Oizumi
K
K
Kobayashi
T
T
D000818:Animals; D001383:Azetidinecarboxylic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004095:Dihydropyridines / Q000493:pharmacokinetics / Q000494:pharmacology; D008297:Male; D000442:Octanols; D051381:Rats; D011918:Rats, Inbred SHR; D012995:Solubility; D014867:Water
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D000442:Octanols; D014867:Water; D001383:Azetidinecarboxylic Acid; C061679:azelnidipine