Additive effect of clarithromycin combined with 14-hydroxy clarithromycin, erythromycin, amoxycillin, metronidazole or omeprazole against Helicobacter pylori.
The in-vitro activities of clarithromycin, 14-OH clarithromycin, erythromycin, amoxycillin, metronidazole and omeprazole against Helicobacter pylori were determined at pH 7.2 and 5.5. At pH 5.5 the activities of clarithromycin and erythromycin decreased approximately 16 times while 14-OH clarithromycin was less influenced. Chequerboard titration indicated that the combined activity of clarithromycin and the other compounds was additive.
Cederbrant
G
G
Department of Clinical Microbiology, Central Hospital, Växjö, Sweden.
Kahlmeter
G
G
Schalén
C
C
Kamme
C
C
D000658:Amoxicillin / Q000494:pharmacology; D017291:Clarithromycin / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004917:Erythromycin / Q000494:pharmacology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009853:Omeprazole / Q000494:pharmacology
C056228:14-hydroxyclarithromycin; D008795:Metronidazole; D004917:Erythromycin; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole