title: Rat ultraviolet ray B photodermatitis: an experimental model of psoriasis vulgaris.
abstract: Ultraviolet ray B (UV-B) induced dermatitis in the rat may be a model for human psoriasis vulgaris. Detailed studies of this model are reported. Rat skin responded to UV-B irradiation quite differently from human, guinea-pig, or mouse skin. Rat UV-B dermatitis was characterized by a sharply demarcated brownish-red lesion with scale formation lasting for 10 days. Histologically, microvascular dilatation, intraepidermal accumulation of polymorphonuclear leucocytes with microabscess, mononuclear cell infiltration at the papillary dermis and hyperproliferation of epidermal cells were observed. These features were similar to those of clinical psoriasis vulgaris in man. Leucocyte suppression, induced by systemic ferritin administration to the irradiated rats, resulted in loss of the epidermal hyperproliferation and inhibition of the tissue leucocytosis. This leucocyte suppression remodelled the picture of the rat UV-B dermatitis into that seen in other mammalian species, where microvascular dilatation and degeneration of keratinocytes (so-called sunburn cells) are characteristic. The irradiated epidermis of the rats treated with ferritin possessed an in vitro PMN chemotactic property. Rat UV-B dermatitis seems to be a useful model to investigate aetiopathogenic mechanisms in psoriasis vulgaris. However, the former heals after injury and does not relapse as does psoriasis.
authors.affiliation: Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakaguma
authors.forename: T
authors.initials: T
authors.lastname: Kambara
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D002634:Chemotaxis, Leukocyte / Q000528:radiation effects; D004195:Disease Models, Animal; D004817:Epidermis / Q000473:pathology / Q000528:radiation effects; D005293:Ferritins / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000502:physiology; D010787:Photosensitivity Disorders / Q000209:etiology / Q000473:pathology*; D011565:Psoriasis / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D005293:Ferritins