title: [Bone resection-reconstruction of the diaphyseal zone in animals. Development of an experimental model, application to the study of biomaterials compared with allografts].
abstract: The aim of this work was to develop an animal model of bony resection-reconstruction of the diaphyseal zone and to test the different bone substitutes in comparison with allografts. Eighteen 2-cm diaphyseal resections of the femur were performed in Beagle dogs. Reconstruction was performed using a bone substitute (5 cryopreserved allografts, 5 blocks of polymethylmetracylate with PMH hydroxyapatite, 8 blocks of phosphocalcium ceramic materials with biphased macropores) associated with centromedullar lockek nail. The PMH blocks gave radiographically and histologically unsatisfactory results. Allografts consolidated in two-thirds of the junctions, consolidating with an exuberant periosteal callus contrasting with minimal intracortical repair. No stress fractures were observed despite normal activity. BCP blocks consolidated in three-fourths of the junctions but pseudoarthrosis at the centre of the block was observed in cases in which the fixation was not perfectly stable. Bone occupied 20 and 24% of the surface of the ceramic block in the central and junctional zones respectively. These findings demonstrated the reliability of internal fixation material in the animal model and allowed us to evaluate the different methods for analysing bone repair on histographic and microradiographic images. In addition, the potential of synthetic material such as MBC might be useful in large resections in mechanically stressed zones.
authors.affiliation: Service d'Orthopédie, CHRU de Nantes.
authors.forename: F
authors.initials: F
authors.lastname: Gouin
authors.forename: N
authors.initials: N
authors.lastname: Passuti
authors.forename: O
authors.initials: O
authors.lastname: Gautier
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D018483:Diaphyses / Q000601:surgery*; D005069:Evaluation Studies as Topic; D005269:Femur / Q000601:surgery; D005594:Fracture Fixation, Intramedullary; D010027:Osteotomy; D014184:Transplantation, Homologous
chemical_list: D001672:Biocompatible Materials
vernacular_title: Résection-reconstruction osseuse en zone diaphysaire chez l'animal. Développement d'un modèle expérimental, application à l'étude des biomatériaux comparés aux allogreffes.