title: Malignant hypercalcemia due to gastric endocrine cell carcinoma.
abstract: A 62-year-old man was admitted to our Neurology Unit due to consciousness disturbance. Laboratory data showed marked hypercalcemia and azotemia. Serum parathyroid hormone-related protein (PTHrP) level was extremely high. We performed intensive hemodialysis for renal failure, but his condition deteriorated rapidly. On day 10, he died of multiple organ failure. The autopsy revealed gastric undifferentiated adenocarcinoma with systemic dissemination. Immunohistological study showed positive PTHrP staining in carcinoid-like parts of the tumor. This is the first reported case of malignant hypercalcemia due to PTHrP-producing carcinoid or endocrine cell carcinoma of the stomach.
authors.affiliation: Department of Neurology, JR Tokyo General Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Sugishita
authors.forename: M
authors.initials: M
authors.lastname: Tanno
authors.forename: M
authors.initials: M
authors.lastname: Kijima
authors.forename: H
authors.initials: H
authors.lastname: Kamoshita
authors.forename: T
authors.initials: T
authors.lastname: Mitamura
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D002276:Carcinoid Tumor / Q000150:complications* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D009363:Neoplasm Proteins / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology
chemical_list: D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins