title: Adenosine-sensitive atrial tachycardia.
abstract: Limited data suggest that adenosine termination of atrial tachycardia is uncommon. To investigate further the effect of adenosine on atrial tachycardia, adenosine (6-12 mg) was administered during sustained atrial tachycardia in 17 patients. All patients underwent electrophysiological study to exclude other mechanisms of supraventricular tachycardia. Mean patient age was 51 +/- 20 years (range 18-82 years). Seven patients had no structural heart disease. The mean atrial tachycardia cycle length was 390 +/- 80 msecs (range 260-580). Sustained atrial tachycardia was induced with atrial extrastimuli in 8 patients, and was either incessant at baseline or developed spontaneously during isoproterenol infusion in 9 patients. Adenosine terminated atrial tachycardia in 3 patients (18%), transiently suppressed atrial tachycardia in 4 patients (23%), and produced AV block without affecting tachycardia cycle length in the remaining 10 patients. Adenosine sensitivity was observed in 3 of 8 patients with tachycardias initiated and terminated by atrial extrastimuli, and in 4 of 9 patients with spontaneous, but not inducible tachycardias including 3 of 4 patients with isoproterenol facilitated tachycardias. Of multiple clinical and electrophysiological variables examined as potential predictors of adenosine sensitivity, only isoproterenol facilitation of spontaneous or inducible sustained tachycardia predicted adenosine sensitivity (P = 0.02). These observations suggest that adenosine-sensitive atrial tachycardia may be more common than previously recognized. Adenosine sensitivity does not appear to be specific for tachycardia mechanism and cannot be predicted by response to pacing. Atrial tachycardias dependent on beta-adrenergic stimulation are most likely to be terminated by adenosine.
authors.affiliation: Department of Medicine, Loyola University Medical Center, Maywood, Illinois, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Kall
authors.forename: D
authors.initials: D
authors.lastname: Kopp
authors.forename: B
authors.initials: B
authors.lastname: Olshansky
authors.forename: C
authors.initials: C
authors.lastname: Kinder
authors.forename: M
authors.initials: M
authors.lastname: O'Connor
authors.forename: C S
authors.initials: CS
authors.lastname: Cadman
authors.forename: D
authors.initials: D
authors.lastname: Wilber
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D002304:Cardiac Pacing, Artificial; D017115:Catheter Ablation; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000139:chemically induced / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007545:Isoproterenol; D008297:Male; D008875:Middle Aged; D013617:Tachycardia, Supraventricular / Q000503:physiopathology* / Q000601:surgery
chemical_list: D000241:Adenosine; D007545:Isoproterenol