[Relationship between intrapenile O2 lever and quantity of intracavernous smooth muscle fibers: current physiopathological concept].
Intracavernous PO2 (mm Hg) was measured during flaccidity in 5 psychogenic impotent patients (control), in 9 patients with venous leak and in 10 patients with arterial disease. No significant difference was observed in the mean PO2 value between the control group 36.2 +/- 5.8 and patients with venous leak 35.6 +/- 6.9 or with arterial disease 34.1 +/- 6.5 at flaccidity. Ten minutes after injection of Prostaglandin E1 (PGE1), the mean value of cavernous PO2 in the control group 83.8 +/- 6.8 was significantly different (p < 0.01) from that in the venous group 67.8 +/- 8.2 and the arterial group 57.8 +/- 10.7 (p < 0.01). Using the computerized analysis and the immunohistochemical staining actin anti-actin, the mean percentage of cavernous smooth fibers was 43.3 +/- 3.6, 34.1 +/- 4.6, and 29.3 +/- 3.4 in the three groups of patients respectively. At flaccidity, the higher the PO2 value, the higher the percentage of cavernous smooth muscle fibers was detected (p < 0.05). A high correlation was observed between the increase in PO2 value after injection of PGE1 and the increase in cavernous smooth muscle content. On the other hand, the mean value of penile brachial index in the psychogenic 0.87 +/- 0.07 was significant different (p < 0.01) from the venogenic group 0.68 +/- 0.06 and the arteriogenic group 0.64 +/- 0.09 (p < 0.01). Similarly, a high correlation was detected between the increase in penile brachial index ratio and the increase in cavernous smooth muscle content. A decrease in the percentage of the intracavernous smooth muscle fibers could be explained by the low oxygen tension at flaccidity and therefore could be responsible for insufficient rigidity during erection.
Sattar
A A
AA
Service d'Urologie Hôpital Erasme, Bruxelles, Belgium.
Salpigidis
G
G
Schulman
C C
CC
Wespes
E
E
D000328:Adult; D007172:Erectile Dysfunction / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018783:Impotence, Vasculogenic / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D010100:Oxygen / Q000097:blood*; D010413:Penis / Q000098:blood supply / Q000737:chemistry*; D011602:Psychophysiologic Disorders / Q000378:metabolism / Q000473:pathology
D010100:Oxygen
Relation entre la teneur en O2 intrapénienne et la quantité des fibres musculaires lisses intracaverneuses: nouveau concept physiopathologique.