title: HLA-DR8 and acute anterior uveitis in ankylosing spondylitis.
abstract: OBJECTIVE
  To identify possible factors in the development of acute anterior uveitis (AUU) in patients with ankylosing spondylitis (AS).
  
  
  METHODS
  We investigated HLA antigens serologically, and HLA-DRB1*08 alleles by polymerase chain reaction-restriction fragment length polymorphism, in 42 Japanese AS patients with and without AAU.
  
  
  RESULTS
  Thirty-six of the AS patients (85.7%) had HLA-B27. Thirteen (65%) of the 20 patients with AAU had HLA-DR8, whereas only 1 (4.5%) of the 22 patients without AAU had DR8. The difference was statistically significant (Pcorr < 0.001).
  
  
  CONCLUSIONS
  Our data suggest that HLA-B27 is strongly associated with AS in Japanese patients and that HLA-DR8 is important for the development of AAU in Japanese patients with AS.
authors.affiliation: University of Tokyo School of Medicine, Japan.
authors.forename: S M
authors.initials: SM
authors.lastname: Monowarul Islam
authors.forename: J
authors.initials: J
authors.lastname: Numaga
authors.forename: Y
authors.initials: Y
authors.lastname: Fujino
authors.forename: K
authors.initials: K
authors.lastname: Masuda
authors.forename: H
authors.initials: H
authors.lastname: Ohda
authors.forename: R
authors.initials: R
authors.lastname: Hirata
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Mitsui
mesh_terms: D000208:Acute Disease; D000328:Adult; D044466:Asian People; D001483:Base Sequence; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D015796:HLA-B27 Antigen / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis*; D059810:HLA-DR Serological Subtypes; D006801:Humans; D008297:Male; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D012016:Reference Values; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000276:immunology*; D014606:Uveitis, Anterior / Q000150:complications / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D015796:HLA-B27 Antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C041559:HLA-DR8 antigen; D015335:Molecular Probes