title: [Fetal-neonatal thrombocytopenia of immunologic origin: current aspects].
abstract: Fetal/neonatal immune thrombocytopenias result from increased platelet destruction by maternal antiplatelet antibodies. There is a risk of intracerebral haemorrhage and therefore of neurological impairment or death during the thrombocytopenic period, especially if a defective platelet function co-exists. As no maternal parameter is predictive of the fetal platelet count, the only reliable assessment of the fetal status depends on the fetal blood sampling. Only in case of materno-fetal alloimmunisation the therapy initiated to reverse fetal thrombocytopenia was shown to be effective, but the optimal mode of antenatal treatment is currently under study. As the neonatal therapy and the management of subsequent pregnancies are somehow different it is mandatory to make the distinction between the auto or allo-origin of the fetal thrombocytopenia. The definition of high risk pregnancies will be of help for the development of a routine screening program.
authors.affiliation: Institut National de Transfusion Sanguine, Service d'Immunologie Leuco-Plaquettaire, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Kaplan
authors.forename: M C
authors.initials: MC
authors.lastname: Morel-Kopp
authors.forename: F
authors.initials: F
authors.lastname: Forestier
authors.forename: M
authors.initials: M
authors.lastname: Dreyfus
authors.forename: F
authors.initials: F
authors.lastname: Daffos
authors.forename: G
authors.initials: G
authors.lastname: Tchernia
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity / Q000502:physiology*; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D017713:Platelet Transfusion; D011247:Pregnancy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D013921:Thrombocytopenia / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy
chemical_list: D016824:Antigens, Human Platelet; D001323:Autoantibodies
vernacular_title: Les thrombopénies foetales-néonatales d'origine immune: aspects actuels.