A new method for estimating dermal absorption from chemical exposure: 2. Effect of molecular weight and octanol-water partitioning.
A new method for estimating dermal absorption including the effects of exposure time and chemistry is described generally in Part 1 of this series. This method accounts for the larger absorption rates during the initial exposure period as well as the hydrophilic barrier which the viable epidermis presents to lipophilic chemicals. A key parameter in this procedure, the ratio of the stratum corneum and epidermis permeabilities (B) depends on molecular weight and octanol-water partitioning. Several approaches for approximating B and its affect on the dermal absorption prediction are discussed here. Generally, the parameter B is only important for highly lipophilic chemicals which also have relatively small molecular weights. When B is important, the recommended prediction for B is based on the Potts and Guy correlation for human stratum corneum permeability.
Bunge
A L
AL
Chemical Engineering and Petroleum Refining Department, Colorado School of Mines, Golden 80401, USA.
Cleek
R L
RL
D000279:Administration, Cutaneous; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D008432:Mathematical Computing; D008722:Methods; D008970:Molecular Weight; D000442:Octanols / Q000737:chemistry; D010599:Pharmacokinetics; D012869:Skin Absorption; D012995:Solubility; D014867:Water / Q000737:chemistry
D000442:Octanols; D014867:Water