A linkage study with D5 dopamine and alpha 2C-adrenergic receptor genes in six multiplex bipolar pedigrees.
Six kindreds containing multiple cases of manic-depressive illness were genotyped with highly polymorphic microsatellite polymorphisms for the D5 dopamine and alpha 2C-adrenergic receptor genes. Evidence of linkage was not found assuming either autosomal dominant or recessive transmission. The non-parametric sib pair test did not yield evidence of linkage.
Byerley
W
W
Department of Psychiatry, University of Utah Medical School, Salt Lake City 84132.
Hoff
M
M
Holik
J
J
Coon
H
H
D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D009679:Nuclear Family; D010375:Pedigree; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D011954:Receptors, Dopamine / Q000235:genetics*; D017447:Receptors, Dopamine D1; D050641:Receptors, Dopamine D5; D012044:Regression Analysis
C547774:ADRA2C protein, human; C493605:DRD5 protein, human; D005819:Genetic Markers; D018341:Receptors, Adrenergic, alpha-2; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D050641:Receptors, Dopamine D5