[The value of selenotherapy in patients with mucoviscidosis].
In cystic fibrosis (CF) patients the antioxidative-oxidative balance is chronically disturbed. Free radicals were generated by bronchial-pulmonal infection and additional exist a deficiency of antioxidative substances by enteral malabsorption especially vitamin E and selenium. Because selenium is an essential content of glutathione peroxidase, which is acting in cytosol and cell membranes, for the present we tested a selenium therapy (peroral sodium selenite 155 micrograms (Se/m2 BSA/d i. e. 4 micrograms Se/kg/d; 4 fold of recommended supply) in 32 CF patients. After three months of this therapy we have seen positive metabolic (normalized content of plasma-selenium, -glutathione peroxidase), endocrine (enhanced efficacy of thyroid hormones, mild increased IgF-I reduced LDL-chol) and clinical consequences (enhanced left ventricular cardiac output), but in three patients side effects (anorexia, nausea, mild hair loss) were observed. Longtime sodium selenite therapy only with 60 micrograms Se/m2 BSA/d over 1 year, stabilized the favourable influences without side effects. For CF patients therefore we recommend a sodium selenite substitution therapy, the best in combination with vitamin E.
Kauf
E
E
Klinik für Kinder- und Jugendmedizin, Friedrich-Schiller-Universität, Jena.
Janitzky
E
E
Vogt
L
L
Winnefeld
K
K
Dawczynski
H
H
Forberger
M
M
Jahreis
G
G
Vogel
H
H
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008134:Long-Term Care; D008297:Male; D017382:Reactive Oxygen Species / Q000378:metabolism; D012643:Selenium / Q000097:blood; D018038:Sodium Selenite / Q000008:administration & dosage* / Q000009:adverse effects
D005609:Free Radicals; D017382:Reactive Oxygen Species; D005979:Glutathione Peroxidase; D012643:Selenium; D018038:Sodium Selenite
Die Bedeutung einer Selenotherapie bei Mukoviszidosepatienten.