title: Acute invasive rhinocerebral zygomycosis in an otherwise healthy patient: case report and review.
abstract: A previously healthy 19-year-old man developed rapidly progressive invasive rhinocerebral zygomycosis due to Apophysomyces elegans. He required extensive surgery and prolonged treatment with high-dose i.v. amphotericin B for cure. This is only the third reported case of acute invasive rhinocerebral zygomycosis in an otherwise healthy patient and the first reported case of infection due to A. elegans in any patient. We review the literature and clinical spectrum of rhinocerebral zygomycosis in otherwise healthy patients and discuss the recently recognized association between A. elegans and zygomycosis in immunocompetent patients.
authors.affiliation: Department of Medicine, Harbor-UCLA Medical Center, Torrance 90509, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Radner
authors.forename: M D
authors.initials: MD
authors.lastname: Witt
authors.forename: J E
authors.initials: JE
authors.lastname: Edwards
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001927:Brain Diseases / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D009090:Mucorales / Q000302:isolation & purification / Q000472:pathogenicity; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D009668:Nose Diseases / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery
chemical_list: D000666:Amphotericin B