The 1994 Merck Frosst Award. Mechanisms of nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal damage--potential for development of gastrointestinal tract safe NSAIDs.
Nonsteroidal anti-inflammatory drugs are widely used for the treatment of osteoarthritis and rheumatoid arthritis, but their ability to cause gastrointestinal bleeding is a significant limitation to this use. A better understanding of the pathogenesis of gastric and intestinal injury induced by these agents will permit the rational design of anti-inflammatory drugs that spare the gastrointestinal tract. In this review, the mechanisms through which nonsteroidal anti-inflammatory drugs are believed to cause gastrointestinal ulceration are reviewed. Several strategies that are being employed to develop gastrointestinal-sparing drugs are outlined.
Wallace
J L
JL
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, AB, Canada.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004064:Digestive System / Q000187:drug effects* / Q000473:pathology; D015195:Drug Design; D006801:Humans; D007422:Intestines / Q000187:drug effects; D013270:Stomach / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal