Determinants of cell entry and intracellular survival of Mycobacterium tuberculosis.
The ability of Mycobacterium tuberculosis to sustain a chronic infection and cause disease in a subset of those infected depends on its products--virulence factors--that enable the organism to enter and survive indefinitely inside mononuclear phagocytic cells by subverting cellular antimicrobial mechanisms. Characterizing these factors is essential to understanding the pathogenesis of M. tuberculosis.
Riley
L W
LW
Divn of International Medicine, Cornell University Medical College, New York, NY 10021, USA.
D000328:Adult; D000818:Animals; D002477:Cells / Q000382:microbiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008322:Mammals; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity* / Q000502:physiology*; D010587:Phagocytosis; D014376:Tuberculosis / Q000382:microbiology*; D014774:Virulence