Comparison of simulated and in-vivo plasma levels of cilastatin following intravenous in-line drug administration.
The primary objective of this work was to establish a method to simulate the plasma levels of cilastatin, a model drug, following an intravenous in-line delivery scheme. In-vivo data in dogs obtained from this work were used to demonstrate the validity of the proposed approach. The in-line drug delivery system consists of a drug containing device which is placed between a large volume parenteral and a patient. Numerous advantages have been identified for this automatic in-line reconstitution delivery system. The numerical convolution integral algorithm was used in this work to perform plasma profile simulation. The results indicated that the simulated cilastatin plasma profile following in-line delivery closely agreed with the in-vivo data.
Wong
J
J
Pharmaceutical Sciences Research and Development, Baxter Healthcare Corporation, Round Lake, Illinois 60073, USA.
Kuu
W Y
WY
Burke
R
R
Johnson
R
R
Wood
R W
RW
D000818:Animals; D015377:Cilastatin / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics; D003198:Computer Simulation; D004285:Dogs; D004334:Drug Administration Schedule; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008432:Mathematical Computing; D008954:Models, Biological; D015203:Reproducibility of Results
D015377:Cilastatin