Effects of water deprivation on renal hydroelectrolytic excretion in chronically Trypanosoma cruzi-infected rats.
The effect of an 8 hour-period of water deprivation on fluid and electrolyte renal excretion was investigated in male Wistar rats infected with the strain São Felipe (12SF) of Trypanosoma cruzi, in comparison with age and sex matched non-infected controls. The median percent reductions in the urinary flow (-40% v-63%) and excretion of sodium (-57% v -79%) were smaller in chagasic than in control rats, respectively. So, chagasic rats excreted more than controls. On the other hand, the median percent decrement in the clearance of creatinine was higher in chagasic (-51%) than in controls (-39%). Thus, chagasic rats showed some disturbed renal hydroelectrolytic responses to water deprivation, expressed by smaller conservation, or higher excretion of water and sodium in association with smaller glomerular filtration rate. This fact denoted an elevation in the fractional excretion of sodium and water.
Rosa
T T
TT
Departamento de Clínica Médica, Faculdade de Ciências da Saúde, Universidade de Brasília, DF, Brasil.
Junqueira Júnior
L F
LF
Mangia
F J
FJ
Veiga
J P
JP
Pádua
F V
FV
D000818:Animals; D014355:Chagas Disease / Q000503:physiopathology*; D002908:Chronic Disease; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014868:Water Deprivation / Q000502:physiology*; D014883:Water-Electrolyte Imbalance / Q000503:physiopathology*