Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.
Cytotoxicity by natural killer (NK) cells is inhibited by major histocompatibility complex (MHC) class I molecules on target cells. This inhibition may be mediated by NK receptors with different MHC specificities. A family of four NK-specific complementary DNAs (cDNAs), designated NKATs (NK-associated transcripts), was identified that encoded related transmembrane proteins, characterized by an extracellular region with two or three immunoglobulin-superfamily domains and by a cytoplasmic domain with an unusual antigen receptor activation motif (ARAM). The distribution of these cDNAs was clonotypic and correlated with NK cell inhibition by particular class I alleles. Thus, NKAT cDNAs may encode receptors for class I molecules on NK cells.
Colonna
M
M
Basel Institute for Immunology, Switzerland.
Samaridis
J
J
D000595:Amino Acid Sequence; D000818:Animals; D000950:Antigens, Ly; D001483:Base Sequence; D015139:Blotting, Southern; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D015235:HLA-B Antigens / Q000276:immunology*; D015236:HLA-C Antigens / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins / Q000737:chemistry; D008969:Molecular Sequence Data; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054349:Receptors, KIR3DS1; D055630:Receptors, NK Cell Lectin-Like; D016415:Sequence Alignment
D000950:Antigens, Ly; D018076:DNA, Complementary; D015235:HLA-B Antigens; D015236:HLA-C Antigens; C093100:KIR2DL1 protein, human; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054349:Receptors, KIR3DS1; D055630:Receptors, NK Cell Lectin-Like