Expression of insulin-like growth factor receptor mRNA in rabbit atherosclerotic lesions.
We have found by 'in situ' hybridization a high level of expression of insulin- like growth factor I receptor (IGF-I R) gene in foam cells of atherosclerotic rabbit aortas. By reaction with either anti- rabbit macrophage (RAM11) or anti smooth muscle cell antibodies we also found that most cells expressing increased amounts of IGF-I R mRNA were of smooth muscle cell origin. Thus, increased IGF-I R mRNA levels might be related to the genesis of the atheroma plaque.
Polanco
J I
JI
Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain.
Berciano
M T
MT
Lafarga
M
M
León
J
J
Pocoví
M
M
Rodríguez-Rey
J C
JC
D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D017403:In Situ Hybridization; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000648:ultrastructure; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D011817:Rabbits; D017451:Receptors, Somatomedin / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D017451:Receptors, Somatomedin