Solvation of platinum anti-cancer drugs in methanol-water mixtures.
Solubilities and transfer chemical potentials of carboplatin, cisplatin, iproplatin, and several related platinum complexes have been determined in methanol-water mixtures. The range of solvation behaviour is discussed in relation to possible oral administration of complexes of this type.
Burgess
J
J
Chemistry Department, University of Leicester, UK.
Drasdo
D N
DN
Patel
M S
MS
D000970:Antineoplastic Agents / Q000737:chemistry*; D016190:Carboplatin / Q000737:chemistry; D002945:Cisplatin / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry*; D012995:Solubility
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C023359:iproplatin; D016190:Carboplatin; D002945:Cisplatin