title: Peptidomimetic antagonists designed to inhibit the binding of CD4 to HIV GP120.
abstract: Attempts to enhance the efficacy of our previously reported CD4 CDR2-like (residues 40-45) mimetic 1 by incorporation of the critical guanidine residue Arg-59 of CD4 are described.
authors.affiliation: Department of Pathobiology, University of Washington, Seattle 98195.
authors.forename: S
authors.initials: S
authors.lastname: Ramurthy
authors.forename: M S
authors.initials: MS
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Nakanishi
authors.forename: R
authors.initials: R
authors.lastname: Shen
authors.forename: M
authors.initials: M
authors.lastname: Kahn
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D015704:CD4 Antigens / Q000378:metabolism*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D007700:Kinetics; D010455:Peptides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D010455:Peptides