title: [Differential diagnostic aspects of progressive spastic paraplegia in adults with emphasis on neurometabolic diseases].
abstract: The differential diagnosis of a progressive spastic paraparesis in the young adult is broad and includes rare neuro-metabolic diseases like cerebro-tendinous xanthomatosis, adrenomyeloneuropathy and hypovitaminosis. Their clinical presentation as well as the result of paraclinical examinations can be similar to those of multiple sclerosis. The early recognition of these diseases is important, because a dietary regimen may reduce the severity and progression of symptoms and signs and genetic counselling can be important. The relevant biochemical examinations for their detection are discussed. These neuro-metabolic diseases have to be differentiated from other neuro-degenerative diseases like amyotrophic lateral sclerosis and hereditary spastic paraplegias.
authors.affiliation: Neurologische und Medizinische Klinik, Universitätsspital Zürich.
authors.forename: W
authors.initials: W
authors.lastname: Waespe
authors.forename: B M
authors.initials: BM
authors.lastname: Vogel Wigger
authors.forename: E
authors.initials: E
authors.lastname: Bächli
authors.forename: E
authors.initials: E
authors.lastname: Boltshauser
mesh_terms: D000326:Adrenoleukodystrophy / Q000175:diagnosis; D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis; D001361:Avitaminosis / Q000175:diagnosis; D001928:Brain Diseases, Metabolic / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007966:Leukodystrophy, Metachromatic / Q000175:diagnosis; D008052:Lipid Metabolism, Inborn Errors / Q000175:diagnosis; D009103:Multiple Sclerosis / Q000175:diagnosis; D015418:Optic Atrophies, Hereditary / Q000175:diagnosis; D010264:Paraplegia / Q000175:diagnosis*; D015419:Spastic Paraplegia, Hereditary / Q000175:diagnosis
vernacular_title: Differentialdiagnostische Aspekte der progredienten spastischen Paraparese beim Erwachsenen mit Betonung neurometabolischer Erkrankungen.