title: Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum.
authors.affiliation: Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
authors.forename: L K
authors.initials: LK
authors.lastname: Basco
authors.forename: P
authors.initials: P
authors.lastname: Eldin de Pécoulas
authors.forename: C M
authors.initials: CM
authors.lastname: Wilson
authors.forename: J
authors.initials: J
authors.lastname: Le Bras
authors.forename: A
authors.initials: A
authors.lastname: Mazabraud
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018432:Drug Resistance, Multiple; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics*; D017354:Point Mutation; D002727:Proguanil; D011739:Pyrimethamine / Q000494:pharmacology*; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D013940:Thymidylate Synthase / Q000235:genetics*; D014227:Triazines / Q000494:pharmacology*
chemical_list: D014227:Triazines; C026009:cycloguanil; D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase; D002727:Proguanil; D011739:Pyrimethamine