title: Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and Gerhardt syndrome associated with Shy-Drager syndrome.
abstract: This is the first report on a case of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with Gerhardt syndrome (paralysis of bilateral vocal cords). A 67-year-old Japanese man suffering from progressive autonomic failure was diagnosed as having Shy-Drager syndrome (SDS) with hyponatremia due to SIADH and severe sleep apnea caused by a bilateral recurrent nerve palsy. Water load test showed alteration in diuresis which was corrected by phenytoin. Arginine vasopressin secretion was not suppressed by plasma osmolality below 280 mOsm/kgH2O. Impairment of the afferent pathways of baroreceptors, or impairment of the osmoreceptors could be speculated as the etiological factor of the SIADH observed in this case.
authors.affiliation: Department of Endocrinology and Metabolism, University of Tsukuba.
authors.forename: H
authors.initials: H
authors.lastname: Sone
authors.forename: Y
authors.initials: Y
authors.lastname: Okuda
authors.forename: C
authors.initials: C
authors.lastname: Bannai
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Yamaoka
authors.forename: Y
authors.initials: Y
authors.lastname: Asakura
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakami
authors.forename: M
authors.initials: M
authors.lastname: Odawara
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
authors.forename: K
authors.initials: K
authors.lastname: Kawai
mesh_terms: D000368:Aged; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications* / Q000209:etiology; D008297:Male; D012791:Shy-Drager Syndrome / Q000150:complications*; D014826:Vocal Cord Paralysis / Q000150:complications*