title: Methodological issues in the assessment of neuropsychologic function after cardiac surgery.
abstract: This report reviews critical issues facing investigators interested in neuropsychologic sequelae after cardiac operations: (1) experimental design; (2) selective attrition; (3) selection of instruments; (4) moderating factors; (5) definitions of cognitive decline; (6) statistical analysis; and (7) clinical significance. Implications for further research in the area are discussed.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Blumenthal
authors.forename: E P
authors.initials: EP
authors.lastname: Mahanna
authors.forename: D J
authors.initials: DJ
authors.lastname: Madden
authors.forename: W D
authors.initials: WD
authors.lastname: White
authors.forename: N D
authors.initials: ND
authors.lastname: Croughwell
authors.forename: M F
authors.initials: MF
authors.lastname: Newman
mesh_terms: D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D006801:Humans; D009483:Neuropsychological Tests