title: [Binswanger's type encephalopathy without alopecia and lumbago in young hypotensive patients].
abstract: Binswanger's type encephalopathy is characterized by progressive dementia and diffuse subcortical ischemic lesions associated with arteriosclerosis. Hypertension is believed to be a major pathogenic factor in causing this encephalopathy but there are some cases of the encephalopathy not suffering from hypertension. In 1985, Yamamura et al. and Fukutake et al. reported familial cases of normotensive juvenile Binswanger's type encephalopathy with alopecia and lumbago, and considered it to be possibly a new clinical syndrome. We reported three cases of relatively young-onset (under the age of 40) Binswanger's type encephalopathy with persistent hypotension. All three patients suffered from neither alopecia nor lumbago. Patient (male aged 40) had repeated episodes of ischemic stroke and had progressive dementia. Patients 2 (male aged 41) and 3 (male aged 34) were not in a state of dementia, but had a history of transient ischemic attacks, and at present are completely symptom-free. Though there were no risk factors for cerebrovascular disease in these cases, the repeated episodes of ischemic stroke and the existence of small multiple lacunes in the basal ganglia on CT and MRI suggest that the white matter damage was principally due to a vascular disorder. In these cases, persistent hypotension was characteristic and might be a factor for the induction and exacerbation of this encephalopathy. These three cases are different from the classic form of Binswanger's type encephalopathy based on hypertension. Normotensive cases have been described before, but our cases do not seem to fall into this category because the blood pressure constantly remained hypotensive.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: First Department (Neurology) of Internal Medicine, Kurume University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Kusuhara
authors.forename: H
authors.initials: H
authors.lastname: Hino
authors.forename: M
authors.initials: M
authors.lastname: Ayabe
authors.forename: H
authors.initials: H
authors.lastname: Shoji
authors.forename: H
authors.initials: H
authors.lastname: Iijima
mesh_terms: D000328:Adult; D000367:Age Factors; D000505:Alopecia; D002540:Cerebral Cortex / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000473:pathology; D015140:Dementia, Vascular / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007022:Hypotension / Q000150:complications*; D017116:Low Back Pain; D008279:Magnetic Resonance Imaging; D008297:Male