Molecular mechanisms and genetics of hyaluronan biosynthesis.
Hyaluronan is an extremely important polysaccharide from both the biological and commercial points of view. This review summarizes the present state of the art concerning the polymer and our understanding of the molecular mechanisms of its synthesis with emphasis on the implications of this understanding for polysaccharide engineering of hyaluronan.
O'Regan
M
M
Fidia Advanced Biopolymers, Abano Terme, Italy.
Martini
I
I
Crescenzi
F
F
De Luca
C
C
Lansing
M
M
D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001692:Biological Transport; D001704:Biopolymers / Q000096:biosynthesis; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D005947:Glucose / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000235:genetics* / Q000378:metabolism; D016695:Glycosyltransferases; D000076002:Hyaluronan Synthases; D006820:Hyaluronic Acid / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D007218:Industrial Microbiology; D008565:Membrane Proteins; D008970:Molecular Weight; D009876:Operon; D011994:Recombinant Proteins / Q000096:biosynthesis; D013291:Streptococcus / Q000235:genetics* / Q000378:metabolism; D014166:Transferases; D005957:UTP-Glucose-1-Phosphate Uridylyltransferase / Q000235:genetics* / Q000378:metabolism; D014533:Uridine Diphosphate Glucose Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D029867:Xenopus Proteins
D001426:Bacterial Proteins; D001704:Biopolymers; D008565:Membrane Proteins; D011994:Recombinant Proteins; D029867:Xenopus Proteins; D006820:Hyaluronic Acid; D014533:Uridine Diphosphate Glucose Dehydrogenase; D014166:Transferases; D016695:Glycosyltransferases; D014453:Glucuronosyltransferase; C056944:HAS1 protein, Xenopus; D000076002:Hyaluronan Synthases; D005957:UTP-Glucose-1-Phosphate Uridylyltransferase; D005947:Glucose