title: Cadherin-dependent cell aggregation is affected by decapeptide derived from rat extracellular super-oxide dismutase.
abstract: A synthetic HAV-containing decapeptide homologous to the amino acid sequence 44R-Q53 in rat extracellular superoxide dismutase B affects cadherin-dependent cell aggregation. Cell lines, some of them transfected, expressing different types of cadherins were tested using in vitro cell aggregation and cell dissociation assays. A concentration-dependent inhibition of aggregation by the EC-SOD-derived HAV-containing peptide was detected only in N-cadherin expressing cells. These results suggest the localisation and possible protective role of EC-SOD B for cells expressing N-cadherin.
authors.affiliation: Interdisciplinary Research Center, KULAK, Kortrijk, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Willems
authors.forename: E
authors.initials: E
authors.lastname: Bruyneel
authors.forename: V
authors.initials: V
authors.lastname: Noë
authors.forename: H
authors.initials: H
authors.lastname: Slegers
authors.forename: A
authors.initials: A
authors.lastname: Zwijsen
authors.forename: R M
authors.initials: RM
authors.lastname: Mège
authors.forename: M
authors.initials: M
authors.lastname: Mareel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015820:Cadherins / Q000494:pharmacology*; D002449:Cell Aggregation / Q000187:drug effects*; D006801:Humans; D007739:L Cells; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011994:Recombinant Proteins; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000494:pharmacology; D014162:Transfection
chemical_list: D015820:Cadherins; D010446:Peptide Fragments; D011994:Recombinant Proteins; D013482:Superoxide Dismutase