Electrophilic 18F from a Siemens 11 MeV proton-only cyclotron.
Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [18O]O2. A method for the routine production of clinically useful quantities of [18F]F2 having a specific activity of 35 Ci/mmol has been developed and implemented using an 11 MeV proton cyclotron and [18O]O2. Based on the yield, purity, reproducibility, and specific activity of [18F]F2 this is the most efficient method reported thus far.
Chirakal
R
R
Department of Nuclear Medicine, Chedoke-McMaster Hospitals, Hamilton, Ontario, Canada.
Adams
R M
RM
Firnau
G
G
Schrobilgen
G J
GJ
Coates
G
G
Garnett
E S
ES
D017357:Cyclotrons; D005462:Fluorine Radioisotopes
D005462:Fluorine Radioisotopes