Defibrotide's activity on leukocytes and platelets in rabbits with diet-induced atherosclerosis.
Oral Defibrotide decreased leukocyte and platelet counts, raised by cholesterol diet, and the area (%) of aorta endothelial surface involved in atherosclerosis. Frequency of intimal thickening in blood vessels of kidneys and hearts and in cardiac valves was reduced by oral Defibrotide by 47%, 29% and 17%. It is suggested that oral Defibrotide reduced the involvement of the aorta in the atherosclerotic process by acting on leukocytes and platelets, to both reduce their number and deactivate them.
Pescador
R
R
Tettamanti
R
R
Salvetti
L
L
Conto
A
A
Porta
R
R
Mantovani
M
M
Ferro
L
L
D000284:Administration, Oral; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D007962:Leukocytes / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D011089:Polydeoxyribonucleotides / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation
D008055:Lipids; D011089:Polydeoxyribonucleotides; C036901:defibrotide