title: Risk of second cancers among lung cancer patients.
abstract: The risk of a second cancer among lung cancer patients was investigated using Finnish Cancer Registry data from 1953 to 1989. Among the 36,528 patients with a primary cancer of the lung, 504 new cancers were diagnosed six months or more after the diagnosis of lung cancer, yielding a standardized incidence ratio significantly lower than expected (SIR = 0.81). A significant excess of cancers of the larynx (SIR = 2.10) and urinary bladder (SIR = 1.35) was observed Among lung cancer patients below 60 years of age, the risks of oesophageal cancer (SIR = 2.47) and kidney cancer (SIR = 2.48) were also significantly elevated. The risk of a second cancer among lung cancer patients increased with the length of follow-up, and there was some indication of an excess risk of oesophageal cancer and leukaemia among lung cancer patients subject to radiotherapy.
authors.affiliation: Department of Oncology and Radiotherapy, Turku University Hospital, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Salminen
authors.forename: E
authors.initials: E
authors.lastname: Pukkala
authors.forename: L
authors.initials: L
authors.lastname: Teppo
authors.forename: S
authors.initials: S
authors.lastname: Pyrhönen
mesh_terms: D000367:Age Factors; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors