[Correlation of dopamine and serotoninergic components in the neurochemical organization of the emetic mechanism].
It was found out in experiments on the pigeons that the destruction of serotoninergic neurons of the brain after preliminary introduction (intraventricular) of 5,6-dihydroxytriptamin blocked the development mechanism of emesis evoked by cisplatin and radiation action, but increased readiness to the development of emetic reaction evoked by apomorphine. On the other hand the destruction of dopaminergic neurons of the brain by 6-hydroxydopamine did not cause emetic condition by introduction emetic-causing substances (apomorphine, cisplatin, copper sulphate) and by X-ray even with a dose, which ensures 100% emetic effect (ED100) on the control group of pigeons. The mechanism of dopamine and serotonin participation in the neurochemical organization of the emetic mechanism is discussed.
Nalótov
S V
SV
Dolzhenko
A T
AT
Komisarov
I V
IV
Talalaienko
O M
OM
Kharin
M O
MO
D015115:5,6-Dihydroxytryptamine / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000009:adverse effects; D001921:Brain / Q000378:metabolism*; D002945:Cisplatin / Q000009:adverse effects; D010856:Columbidae; D003300:Copper / Q000009:adverse effects; D019327:Copper Sulfate; D004298:Dopamine / Q000378:metabolism*; D004347:Drug Interactions; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D016627:Oxidopamine / Q000494:pharmacology; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D012701:Serotonin / Q000378:metabolism*; D014839:Vomiting / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control
D012701:Serotonin; D003300:Copper; D016627:Oxidopamine; D019327:Copper Sulfate; D001058:Apomorphine; D002945:Cisplatin; D004298:Dopamine; D015115:5,6-Dihydroxytryptamine
Spivvidnoshennia dofamin- i serotoninerhichnykh komponentiv u neïrokhimichniĭ orhanizatsiĭ mekhanizmu bliuvannia.