Multisite clinical trials in alcoholism treatment research: organizational, methodological and management issues.
Multisite clinical trials have two major advantages over single-site studies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population being studied. However, they are more complex to implement than single-site studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite design, management of such studies, and some statistical issues.
Fuller
R K
RK
National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20892-7003.
Mattson
M E
ME
Allen
J P
JP
Randall
C L
CL
Anton
R F
RF
Babor
T F
TF
D000437:Alcoholism / Q000523:psychology / Q000534:rehabilitation*; D002985:Clinical Protocols; D006801:Humans; D015337:Multicenter Studies as Topic / Q000379:methods*; D010043:Outcome and Process Assessment, Health Care; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012106:Research