title: Rare case with metastatic involvement of hypothalamo-pituitary and pineal body presenting as hypopituitarism and diabetes insipidus.
abstract: An unusual case with metastatic spread of a small oat cell lung carcinoma to the hypothalamo-pituitary region and pineal body presenting as pituitary insufficiency is reported. Computed tomographic scan revealed an isodense mass in the hypothalamo-pituitary region and pineal body that was strongly enhanced by contrast medium. Magnetic resonance imaging demonstrated a downward displacement of the posterior lobe of the pituitary by the hypothalamo-pituitary mass. Dynamic assessment of hypothalamo-pituitary function showed hypopituitarism and diabetes insipidus; partial recovery was observed with the improvement in the carcinoma by chemotherapy. The brain was subsequently irradiated. The patient survived 10 months.
authors.affiliation: Department of Internal Medicine, Hamamatsu University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Suganuma
authors.forename: T
authors.initials: T
authors.lastname: Yoshimi
authors.forename: T
authors.initials: T
authors.lastname: Kita
authors.forename: H
authors.initials: H
authors.lastname: Okano
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Oki
authors.forename: K
authors.initials: K
authors.lastname: Chida
authors.forename: A
authors.initials: A
authors.lastname: Sato
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000556:secondary*; D003919:Diabetes Insipidus / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology*; D007029:Hypothalamic Neoplasms / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D010870:Pineal Gland; D010911:Pituitary Neoplasms / Q000556:secondary*