title: [The effect of erythropoietin on fibrinolysis in hemodialyzed patients].
abstract: BACKGROUND
  According to some data treatment with human recombinant erythropoietin (EPO) in dialyzed patients leads to a more frequent occurrence of thromboses. One of the possible causes could be reduced fibrinolysis. The objective of the present study was to assess the effect of EPO in dialyzed patients on two key enzymes of fibrinolysis, i.e. the tissue activator of plasminogen (t-PA) and the inhibitor of the plasminogen activator (PAI-1).
  
  
  RESULTS
  In eight patients dialyzed for prolonged periods examined under otherwise equal conditions before EPO treatment (haematocrit 22.9%--median value) and after 9.5 weeks of EPO treatment (Recormon, s.c.) when a haematocrit of 30% was achieved, activities (chromogenic substrates) and antigens (ELISA of t-PA and PAI) were assessed. All examinations were made before and after venous occlusion. Between examinations made before treatment and during EPO treatment no significant difference was found in the t-Pa activities assessed before venous occlusion (before EPO 0.9 IU/ml--during EPO 0.6, not significant Wilcoxon's paired test) nor after venous occlusion (3.2-3.8, n.s.). PAI activities before venous occlusion (10.9 U/ml-18.3, n.s.) and after venous occlusion (9.7-11.5, n.s.) did not differ significantly either, when comparing values before and in the course of EPO treatment. Similarly as in the case of activities in antigens t-PA and PAI no difference was found before and during EPO.
  
  
  CONCLUSIONS
  No effect of EPO on the investigated indicators of fibrinolysis was found. The results of the presented investigation are at variance with the idea that EPO reduces fibrinolysis in dialyzed patients and thus contributes to the development of thrombotic complications.
authors.affiliation: Interní oddĕlení VFN, Praha, Strahov.
authors.forename: K
authors.initials: K
authors.lastname: Opatrný
authors.forename: L
authors.initials: L
authors.lastname: Vít
authors.forename: S
authors.initials: S
authors.lastname: Opatrná
authors.forename: B
authors.initials: B
authors.lastname: Bodláková
authors.forename: S
authors.initials: S
authors.lastname: Sulková
authors.forename: K
authors.initials: K
authors.lastname: Opatrný
authors.forename: M
authors.initials: M
authors.lastname: Krist'an
mesh_terms: D000328:Adult; D000740:Anemia / Q000209:etiology / Q000628:therapy; D004921:Erythropoietin / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D006435:Renal Dialysis; D013927:Thrombosis / Q000209:etiology
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin
vernacular_title: Vliv erytropoetinu na fibrinolýzu u hemodialyzovaných nemocných.