Inhibition by antidepressants of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.
Effects of antidepressive drugs on glibenclamide-sensitive K+ currents were investigated using follicle-enclosed Xenopus oocytes. Antidepressive drugs, imipramine, desipramine, and amitriptyline, inhibited the K+ currents with IC50 (microM) values of 35.4, 39.7, and 87.7, respectively. The K+ current blocking actions of antidepressants appear to be associated with their local anesthetic related structures.
Sakuta
H
H
Department of Pharmacology, National Defense Medical College, Saitama, Japan.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology; D001578:Benzopyrans / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D009865:Oocytes; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000187:drug effects*; D014982:Xenopus laevis
D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D001578:Benzopyrans; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D000639:Amitriptyline; D007099:Imipramine; C074338:Y 26763; D005905:Glyburide; D003891:Desipramine