title: [The efficacy of midazolam-famotidine suppository for premedication in children].
abstract: We evaluated the efficacy of midazolam-famotidine suppository (M-F suppository) for premedication in children. After obtaining informed parental consent, we studied children aged 5m-7y, ASA I status, scheduled for minor elective surgery. The suppository group (n = 26) was given suppository of both midazolam 0.5 mg.kg-1 and famotidine 2 mg.kg-1, and the intramuscular injection group (n = 19) was given hydroxyzine 1 mg.kg-1. In the suppository group, gastric pH (3.90 +/- 0.34) was significantly higher, and gastric volume (1.88 +/- 0.54 ml) was significantly less than in the intramuscular injection group (1.82 +/- 0.15, 8.42 +/- 1.76 ml). The M-F suppository may offer similar sedative effect as an intramuscular injection of hydroxyzine. We concluded that the M-F suppository is an effective premedicant for pediatric patients.
authors.affiliation: Department of Anesthesiology, Nobeoka Prefectural Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Iwamoto
authors.forename: R
authors.initials: R
authors.lastname: Uchiumi
authors.forename: T
authors.initials: T
authors.lastname: Hidaka
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Honda
authors.forename: Y
authors.initials: Y
authors.lastname: Okuno
mesh_terms: D000285:Administration, Rectal; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D015738:Famotidine / Q000008:administration & dosage*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage; D007223:Infant; D007273:Injections, Intramuscular; D008874:Midazolam / Q000008:administration & dosage*; D011229:Preanesthetic Medication; D013488:Suppositories
chemical_list: D004338:Drug Combinations; D013488:Suppositories; D006919:Hydroxyzine; D015738:Famotidine; D008874:Midazolam