title: Six loci mapped on to human chromosome 2p are assigned to sheep chromosome 3p.
abstract: Six loci, apoliproprotein B (including Ag(x) antigen), immunoglobulin kappa constant region (IGKC), luteinizing hormone/choriogonadotrophin receptor, avian myelocytomatosis viral related oncogene, neuroblastoma derived, ornithine decarboxylase, and proopiomelanocortin (adrenocorticotropin/beta-lipotropin) (POMC), were newly assigned to sheep chromosome 3p using a chromosomally characterized minipanel of sheep-hamster cell hybrids. Isotopic in situ hybridization of IGKC to sheep chromosome 3p22-p17 is reported, confirming the cell hybrid assignment. As these loci are all known to map to human chromosome 2p, this study demonstrates that this chromosomal segment is extensively conserved in sheep. Only POMC has been previously assigned to cattle chromosome 11, which is the equivalent of sheep chromosome 3p. Therefore, we predict that the other loci assigned in this study to sheep 3p are likely to be located on cattle 11. The provisional assignment of an additional locus, annexin-like to sheep chromosome 3p is also reported.
authors.affiliation: AgResearch Invermay Agricultural Centre, Mosgiel, New Zealand.
authors.forename: T E
authors.initials: TE
authors.lastname: Broad
authors.forename: D J
authors.initials: DJ
authors.lastname: Burkin
authors.forename: L M
authors.initials: LM
authors.lastname: Cambridge
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: P E
authors.initials: PE
authors.lastname: Lewis
authors.forename: H G
authors.initials: HG
authors.lastname: Morse
authors.forename: D
authors.initials: D
authors.lastname: Geyer
authors.forename: P D
authors.initials: PD
authors.lastname: Pearce
authors.forename: H A
authors.initials: HA
authors.lastname: Ansari
authors.forename: D W
authors.initials: DW
authors.lastname: Maher
mesh_terms: D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics; D015139:Blotting, Southern; D002874:Chromosome Mapping / Q000662:veterinary*; D002889:Chromosomes, Human, Pair 2; D006224:Cricetinae; D016259:Genes, myc; D006801:Humans; D006822:Hybrid Cells; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D017403:In Situ Hybridization; D009955:Ornithine Decarboxylase / Q000235:genetics; D011333:Pro-Opiomelanocortin / Q000235:genetics; D011974:Receptors, LH / Q000235:genetics; D012756:Sheep / Q000235:genetics*
chemical_list: D001055:Apolipoproteins B; D007145:Immunoglobulin kappa-Chains; D011974:Receptors, LH; D011333:Pro-Opiomelanocortin; D009955:Ornithine Decarboxylase