Further studies on the effects of chronic clozapine on regional extracellular dopamine levels in the brain of conscious rats.
The effect of chronic oral treatment with clozapine (20 mg/kg daily for 21 days) on the extracellular concentrations of dopamine, dihydroxyphenylacetic acid and homovanillic acid in the dorsolateral anterior striatum, nucleus accumbens and frontal cortex was studied by microdialysis in conscious rats. Basal levels of dopamine and its metabolites in the three brain regions of rats treated chronically with clozapine were not significantly different from those of vehicle-treated rats. A subcutaneous challenge dose of clozapine (20 mg/kg) significantly increased the extracellular concentrations of dopamine and its metabolites in the three brain regions, with no differences between chronic vehicle- and clozapine-treated rats.
Invernizzi
R
R
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Pozzi
L
L
Samanin
R
R
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects; D003024:Clozapine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism*; D005625:Frontal Lobe / Q000187:drug effects; D006719:Homovanillic Acid; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects; D051381:Rats
D015102:3,4-Dihydroxyphenylacetic Acid; D003024:Clozapine; D004298:Dopamine; D006719:Homovanillic Acid