Contralateral suppression of transient evoked otoacoustic emissions in guinea-pigs: effects of gentamicin.
A single injection of gentamicin in the awake guinea-pig induces a transient blockade of the suppression by contralateral white noise of tone-pip evoked compound action potential (Smith et al., 1994). We report here the reversible blockade, in exactly the same experimental conditions, of the suppression of click-evoked otoacoustic emissions. These observations confirm the transient action of gentamicin at the medial efferent/outer hair cell synapse, likely via the reversible blockade of calcium channels observed in vitro (Dulon et al., 1989).
Aran
J M
JM
Laboratoire d'Audiologie Expérimentale, Hôpital Pellegrin, Bordeaux, France.
Erre
J P
JP
Avan
P
P
D000161:Acoustic Stimulation; D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000294:innervation*; D007839:Functional Laterality; D005839:Gentamicins / Q000009:adverse effects* / Q000494:pharmacology*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D013569:Synapses / Q000187:drug effects
D005839:Gentamicins