title: Perfusion lung scintigraphy in primary pulmonary hypertension.
abstract: 15 cases of primary pulmonary hypertension were classified into two groups by patterns of perfusion lung scintigraphy. Perfusion scintigrams showed multiple, small, ill-defined defects (mottled + ve) pattern in eight cases, and the remaining seven cases had a normal (mottled - ve) pattern. The mean pulmonary arterial pressure in patients with a mottled pattern (54 +/- 10 mmHg) was higher than in those with a normal pattern (42 +/- 9 mmHg, p < 0.05). There were no significant differences between the two groups in right ventricular ejection fraction, partial pressures of oxygen in the arterial blood or alveolo-arterial oxygen difference. All the patients with a mottled pattern died within 2 years following the lung scintigraphy. There was a significant difference in the survival curves between the two groups. Although our statistical analysis must be evaluated with caution because of small numbers of patients it is suggested that perfusion lung scintigraphy is useful in assessing the prognosis in primary pulmonary hypertension.
authors.affiliation: Department of Radiology and Nuclear Medicine, National Cardiovascular Center, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Hayashida
authors.forename: T
authors.initials: T
authors.lastname: Uehara
authors.forename: T
authors.initials: T
authors.lastname: Shimonagata
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000401:mortality; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D011379:Prognosis; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D015996:Survival Rate; D013668:Technetium Tc 99m Aggregated Albumin; D014692:Ventilation-Perfusion Ratio / Q000502:physiology
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin