Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects.
Cells expressing the Glu 27 beta 2-adrenoceptor polymorphism show attenuated down-regulation of the receptor after long-term exposure to agonist. We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma. Glu 27 homozygotes had a four-fold higher geometric mean methacholine PD20 (provocative dose) than individuals who were homozygous for the wild-type (Gln 27) form of the receptor; heterozygotes had an intermediate value (3.23, 0.86, 1.96 mumol, respectively). These data suggest that beta 2-adrenoceptor genotype is important in the establishment of the asthmatic phenotype.
Hall
I P
IP
Department of Medicine, University Hospital of Nottingham, UK.
Wheatley
A
A
Wilding
P
P
Liggett
S B
SB
D000328:Adult; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology; D001483:Base Sequence; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016210:Methacholine Chloride; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
D018343:Receptors, Adrenergic, beta-2; D016210:Methacholine Chloride