Serum levels of interleukin-2 receptor (CD 25) in patients with Hodgkin's disease, with special reference to age and prognosis.
BACKGROUND
The serum levels of soluble interleukin-2 receptor (S-sIL-2R) have been shown to be related to clinical outcome in Hodgkin's disease (HD). sIL-2R may be involved in or aggravate the immunodeficiency seen in HD patients. This immunodeficiency is most pronounced in elderly patients.


METHODS
S-sIL-2R was determined in 127 untreated patients with HD, diagnosed between 1979 and 1991, in order to evaluate its prognostic value in relation to other known prognostic variables with special emphasis on the elderly.


RESULTS
S-sIL-2R levels were significantly higher in patients with stages III-IV and with B-symptoms (p < 0.001) but not in patients over 60 years of age. In multivariate analyses, S-sIL-2R, stage and S-orosomucoid were the most important prognostic factors in all patients and S-sIL-2R was the only prognostic factor in patients over the age of 60.


CONCLUSIONS
The results indicate a future role for estimation of S-sIL-2R in the management of patients with HD.
Enblad
G
G
Department of Oncology, University of Uppsala, Akademiska sjukhuset, Sweden.
Sundström
C
C
Gronowitz
S
S
Glimelius
B
B
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009961:Orosomucoid / Q000032:analysis; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D013937:Thymidine Kinase / Q000097:blood
D009961:Orosomucoid; D015375:Receptors, Interleukin-2; D013937:Thymidine Kinase