An informativity index for multilocus DNA fingerprints.
An informativity index for multilocus DNA fingerprints, r, was developed. It is based upon the Shannon information that a paternal DNA fingerprint conveys about the offspring phenotype pattern. Both simulation and empirical data reveal that the index r is strongly correlated with the mean log likelihood ratio (paternity vs. nonpaternity) expected in trio cases of true paternity. Since r can be estimated from DNA fingerprints of unrelated individuals in advance, it will provide an easy means to assess the potential utility of a given probe/enzyme combination in kinship testing.
Krawczak
M
M
Institut für Humangenetik, Medizinische Hochschule, Hannover, Germany.
Lubjuhn
T
T
D000818:Animals; D001717:Birds / Q000235:genetics; D016172:DNA Fingerprinting; D005260:Female; D006801:Humans; D008297:Male; D010334:Paternity; D011110:Polymorphism, Genetic