Treatment of hemifacial spasm with botulinum toxin. Value of preinjection electromyography abnormalities for predicting postinjection lower facial paresis.
Thirty-two patients with hemifacial spasm were treated with 61 botulinum toxin (BT) injections. Some patients had post-BT lower facial paresis (LFP+group) while others did not suffer this side effect (LFP-group). Abnormal electromyography (EMG) recordings were more frequent in the LFP+ group (6/11) than in the LFP- group (3/21; p < 0.05). This result suggests that an EMG performed before any BT injection could detect the patients with a higher risk for this side effect. The first dose of BT might be lowered in such cases.
Angibaud
G
G
Service de Neurologie et d'Explorations Fonctionnelles Neurologiques, Hôpital Purpan, Toulouse, France.
Moreau
M S
MS
Rascol
O
O
Clanet
M
M
D000368:Aged; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000009:adverse effects*; D004576:Electromyography / Q000187:drug effects*; D005152:Facial Muscles / Q000187:drug effects / Q000503:physiopathology; D005158:Facial Paralysis / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013035:Spasm / Q000188:drug therapy* / Q000503:physiopathology
D001905:Botulinum Toxins