Strain differences in sleep and other pathophysiological sequelae of influenza virus infection in naive and immunized mice.
To characterize behavioral and physiological alterations induced by viral respiratory infection, C57BL/6 and BALB/c strains of mice were monitored for 2 days before and 4 days after intranasal inoculation with influenza virus. Both strains developed hypothermia, decrease locomotor activity, and decreased delta-wave amplitude during sleep within 24 h after inoculation. However, infected C57BL/6 mice also spent more time in slow-wave sleep, but infected BALB/c mice did not. The increased SWS in C57BL/6 mice occurred during the lights-off phase of the circadian cycle, and resulted in loss of the normal circadian rhythmicity of sleep. Increased sleep also occurred after viral challenge of immunized C57BL/6 mice, but was not observed after secondary challenge of immunized BALB/c mice. These data indicate that sleep alterations may accompany viral infections in some, but not all, strains of mice. The dissimilar sleep patterns seen in C57BL/6 and BALB/c mice after influenza infection may reflect differences in their immune response to influenza virus.
Toth
L A
LA
Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Rehg
J E
JE
Webster
R G
RG
D000818:Animals; D002940:Circadian Rhythm; D004569:Electroencephalography; D004576:Electromyography; D007114:Immunization; D007252:Influenza Vaccines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000503:physiopathology*; D012890:Sleep / Q000276:immunology / Q000502:physiology*; D013045:Species Specificity; D013997:Time Factors; D014851:Wakefulness
D007252:Influenza Vaccines