title: [Fibrinogen and leukocyte number in coronary heart disease. Correlation with angiography and clinical degree].
abstract: In 302 consecutively patients fibrinogen (Clauss method) and leucocyte count were related to the angiographic and clinical degree of coronary atherosclerosis. Fibrinogen (mg/dl) was statistically higher compared to control (C, 267 +/- 55) in patients with one-vessel disease (1-vd (306 +/- 67), 2-vd (331 +/- 73), and 3-vd (328 +/- 62)). Patients with coronary sclerosis (Scl, luminal irregularities and/or stenosis under 50%) showed a tendency to higher fibrinogen levels (291 +/- 58) as compared to controls. Leucocyte count (10(9)/L) compared to C (6.7 +/- 1.8) was significantly higher in 1-vd (7.6 +/- 2.0) and 2-vd (7.6 +/- 1.9). A subgroup analysis was performed with 100 patients having severe forms of angina pectoris (AP III according to the CCS classification, unstable angina). Hundred-sixteen patients with unstable angina (390 +/- 79), particularly with angina at rest during the last 48 h were characterized by the highest fibrinogen values (423 +/- 89, class III B/C Braunwald). Leucocyte count in patients with stable angina (7.2 +/- 1.4) and angina at rest (9.3 +/- 2.7) was significantly higher as compared to control (6.7 +/- 1.8). Hyperfibrinogenemia and relative leucocytosis correlate with the angiographic and clinical extent of coronary artery disease and may offer evidence of a higher degree of thrombogenesis associated with components of inflammation.
authors.affiliation: Kardiologische Klinik, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen.
authors.forename: E
authors.initials: E
authors.lastname: Miche
authors.forename: D
authors.initials: D
authors.lastname: Baller
authors.forename: U
authors.initials: U
authors.lastname: Gleichmann
authors.forename: H
authors.initials: H
authors.lastname: Mannebach
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: W
authors.initials: W
authors.lastname: Prohaska
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000145:classification / Q000175:diagnosis; D000789:Angina, Unstable / Q000097:blood / Q000145:classification / Q000175:diagnosis; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000145:classification / Q000175:diagnosis*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000145:classification / Q000175:diagnosis
chemical_list: D005340:Fibrinogen
vernacular_title: Fibrinogen und Leukozytenzahl bei koronarer Herzkrankheit. Korrelationen zum angiographischen und klinischen Schweregrad.