[A case of acute lupus pneumonitis].
Forty-five-year-old woman with systemic lupus erythematosus who had treated with sulindac had exacerbation of her rash and arthralgia. On her admission for treatment, chest X-ray showed bilateral pathy infiltrates in lower lung fields. We performed a transbronchial lung biopsy. Immunohistopathologic studies showed granular deposits of IgM and C 3 in the subendothelial area of pulmonary arteriolae. She was treated with prednisolone (1.0 mg/kg/day) and deoxyspergualin. Chest X-ray showed improvement and her serum IgG, anti-DNA antibodies and complement diminished quickly. We suggest that these immunopathologic observations may be important in the pathogenesis of the lung injury in systemic lupus erythematosus.
Saeki
T
T
Department of internal medicine, Kitami Red Cross Hospital, Hokkaido.
Taneichi
K
K
Shibaki
H
H
D000208:Acute Disease; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D011014:Pneumonia / Q000209:etiology*
D003176:Complement C3; D007075:Immunoglobulin M