title: Contrast enhancement in spinal nerve roots: an experimental study.
abstract: OBJECTIVE
  To examine histopathologically the endothelium of contrast-enhancing spinal nerve roots.
  
  
  METHODS
  In five adult baboons, chronic compression of the left S-1 spinal nerve root sufficient to produce a change in the evoked potential was produced by means of a suture tied around the nerve. The animals were studied with MR at 8 and 16 days after nerve compression and then killed for histopathologic and electron microscopic studies. Histopathologic changes in the nerve roots demonstrating contrast enhancement were described.
  
  
  RESULTS
  In all compressed spinal nerves, contrast enhancement was observed. Histopathologically, wallerian degeneration of the root and inflammation and disruption of the endothelium of capillaries in the spinal nerve were evident.
  
  
  CONCLUSIONS
  Degenerative changes in the nerve root and the capillary endothelium of a lumbar spinal nerve are associated with contrast enhancement.
authors.affiliation: Department of Radiology, Medical College of Wisconsin, Milwaukee, USA.
authors.forename: C
authors.initials: C
authors.lastname: Nguyen
authors.forename: V M
authors.initials: VM
authors.lastname: Haughton
authors.forename: K C
authors.initials: KC
authors.lastname: Ho
authors.forename: H S
authors.initials: HS
authors.lastname: An
authors.forename: J B
authors.initials: JB
authors.lastname: Myklebust
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: R
authors.initials: R
authors.lastname: Xu
authors.forename: J M
authors.initials: JM
authors.lastname: Harb
mesh_terms: D000818:Animals; D008279:Magnetic Resonance Imaging; D010215:Papio; D013126:Spinal Nerve Roots / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D014463:Ultrasonography