Hyper-dopaminemia may produce an increased outlet resistance of the prostatic urethra: a case report of malignant pheochromocytoma.
We report on a 43-year-old man with difficult urination attributed to malignant pheochromocytoma with hyper-dopaminemia. A decrease and increase in the plasma dopamine values during the clinical course clearly coincided with improvement and deterioration, respectively, in urination difficulty. The prostatic peak pressure decreased by 37% when the plasma dopamine value was minimal. Detrusor function was normal throughout. Endocrinological and urodynamic studies suggested that hyper-dopaminemia produced an increased outlet resistance of the prostatic urethra without altering detrusor function. Thus, peripheral dopaminergic systems may influence voiding mechanisms, especially those involving the proximal urethra.
Araki
S
S
Department of Urology, Saitama Medical School, Japan.
Kato
M
M
Kase
H
H
Okada
K
K
D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D000328:Adult; D004298:Dopamine / Q000097:blood*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D010673:Pheochromocytoma / Q000097:blood / Q000150:complications* / Q000556:secondary; D014521:Urethra / Q000503:physiopathology*; D014555:Urination Disorders / Q000209:etiology*; D014563:Urodynamics / Q000502:physiology
D004298:Dopamine