Signal transduction via serine/threonine kinase receptors.
A number of serine/threonine kinase receptors have recently been identified. Most of the members of this family are type I or type II receptors for proteins in the transforming growth factor-beta (TGF-beta) superfamily. The type I and type II receptors form heteromeric receptor complexes after binding of the ligands, and transduce intracellular signals. TGF-beta type I receptor needs type II receptor for ligand binding, and type II receptor needs type I receptor for signalling. The signal transducing molecules that interact with heteromeric serine/threonine kinase receptor complexes remain to be elucidated; cyclin-dependent kinases and the retinoblastoma protein appear to be downstream elements in the antiproliferative pathway of TGF-beta.
Miyazono
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K
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.
ten Dijke
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P
Yamashita
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H
Heldin
C H
CH
D000818:Animals; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction
D017978:Receptors, Growth Factor; D017346:Protein Serine-Threonine Kinases