title: Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor.
abstract: Regenerative proliferation occurs in the inner-ear sensory epithelial of warm-blooded vertebrates after insult. To determine how this proliferation is controlled in the mature mammalian inner ear, several growth factors were tested for effects on progenitor-cell division in cultured mouse vestibular sensory epithelia. Cell proliferation was induced in the sensory epithelium by transforming growth factor alpha (TGF-alpha) in a dose-dependent manner. Proliferation was also induced by epidermal growth factor (EGF) when supplemented with insulin, but not EGF alone. These observations suggest that stimulation of the EGF receptors by TGF-alpha binding, or EGF (plus insulin) binding, stimulates cell proliferation in the mature mammalian vestibular sensory epithelium.
authors.affiliation: Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle 98195, USA.
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: E C
authors.initials: EC
authors.lastname: Oesterle
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004848:Epithelium / Q000033:anatomy & histology / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology; D018069:Hair Cells, Vestibular / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development*; D007328:Insulin / Q000494:pharmacology; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009924:Organ Culture Techniques; D012444:Saccule and Utricle / Q000187:drug effects / Q000254:growth & development; D016211:Transforming Growth Factor alpha / Q000494:pharmacology*; D015854:Up-Regulation
chemical_list: D006133:Growth Substances; D007328:Insulin; D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor