title: Hematopoietic growth factor receptors: structure variations and alternatives of receptor complex formation in normal hematopoiesis and in hematopoietic disorders.
abstract: Receptors of most hematopoietic growth factors are structurally related and grouped in the hematopoietin or cytokine receptor superfamily. In this paper, we will first review the general principles of hematopoietin receptor complex formation and cytoplasmic signaling. Subsequently, the significance of defective hematopoietic growth factor receptors for the development of hematological diseases will be discussed.
authors.affiliation: Dept. of Pathology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: L M
authors.initials: LM
authors.lastname: Budel
authors.forename: F
authors.initials: F
authors.lastname: Dong
authors.forename: B
authors.initials: B
authors.lastname: Löwenberg
authors.forename: I P
authors.initials: IP
authors.lastname: Touw
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006133:Growth Substances / Q000737:chemistry*; D006410:Hematopoiesis; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D011940:Receptor Aggregation; D016184:Receptors, Colony-Stimulating Factor / Q000737:chemistry*; D015398:Signal Transduction
chemical_list: D006133:Growth Substances; D008024:Ligands; D016184:Receptors, Colony-Stimulating Factor