title: Direct fetal administration of adenosine for the termination of incessant supraventricular tachycardia.
abstract: BACKGROUND
  Adenosine terminates supraventricular reentry tachycardia safely and effectively in the pediatric age group.
  
  
  METHODS
  The recurrence of pretreated incessant tachycardia led to severe hydrops in a 28-week-old fetus. The tachycardia was terminated instantly with direct fetal administration of adenosine via the umbilical vein. Normal heart rate and rhythm were then preserved temporarily with digoxin and flecainide.
  
  
  CONCLUSIONS
  Direct fetal adenosine administration might be helpful in the treatment of fetal reentry tachycardias if the sinus rhythm achieved quickly can be preserved by long-acting antiarrhythmic drugs. Such a combined therapeutic approach might be especially advantageous in hydropic fetuses.
authors.affiliation: Department of Pediatric Cardiology, University of Münster, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kohl
authors.forename: S
authors.initials: S
authors.lastname: Tercanli
authors.forename: D
authors.initials: D
authors.lastname: Kececioglu
authors.forename: W
authors.initials: W
authors.lastname: Holzgreve
mesh_terms: D000241:Adenosine / Q000008:administration & dosage*; D004077:Digoxin / Q000008:administration & dosage; D005260:Female; D005313:Fetal Death; D005424:Flecainide / Q000008:administration & dosage; D005865:Gestational Age; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging* / Q000473:pathology; D007275:Injections, Intravenous; D011247:Pregnancy; D012008:Recurrence; D013617:Tachycardia, Supraventricular / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014463:Ultrasonography; D014471:Umbilical Veins
chemical_list: D004077:Digoxin; D000241:Adenosine; D005424:Flecainide