Expression of granulocyte colony-stimulating factor receptor on CD10-positive human B-cell precursors.
We examined the expression of CD10 and G-CSF receptor (G-CSFR) on the lymphoid population of mononuclear cells obtained from bone marrow (BM) using two-colour analysis. In the BM of children with ALL in remission, the CD10+ population was significantly increased (20.6 +/- 5.1% compared with that of controls (2.5 +/- 0.5%). More than half (61.3 +/- 2.9%) of the CD10+ cells co-expressed G-CSFR, but not CD13. These results indicate G-CSFR+ B-cell precursors are markedly increased in BM of ALL in remission, suggesting the probable involvement of G-CSF in the human early B-cell ontogeny.
Inukai
T
T
Department of Paediatrics, Yamanashi Medical University, Japan.
Sugita
K
K
Iijima
K
K
Tezuka
T
T
Goi
K
K
Kojika
S
S
Shiraishi
K
K
Kagami
K
K
Nakazawa
S
S
D000293:Adolescent; D000951:Antigens, Neoplasm / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D008297:Male; D015260:Neprilysin / Q000032:analysis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000276:immunology*; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000032:analysis*; D012074:Remission Induction
D000951:Antigens, Neoplasm; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D015260:Neprilysin