Vessel dilator is associated with survival after acute myocardial infarction.
To assess whether infarct size, ischemic area and/or survival correlates with circulating atrial natriuretic peptides (long acting sodium stimulator, vessel dilator, or atrial natriuretic factor), these peptides were measured in a canine model of acute myocardial infarction. Elevations in the circulating concentrations of atrial natriuretic factor, vessel dilator, and long acting sodium stimulator were significant (P < 0.05) within 6 min of coronary occlusion of the left anterior descending coronary artery. The percentage of ischemic myocardium ranged from 20 to 67% with a mean of 37 +/- 17%. The area of infarction ranged from 1 to 13% with the infarcted area of non-survivors being twice that of survivors. Both the ischemic and infarcted areas correlated (P < 0.05) with the circulating concentrations of these atrial natriuretic peptides. Survival correlated also with the circulating plasma concentrations of vessel dilator, atrial natriuretic factor and long acting sodium stimulator (P < 0.05). When these circulating concentrations were evaluated, however, by determining their area under their respective concentrations curves and expressing each as the log area under plasma concentration-time curve (area under the curve) per kg of weight (Y = 58.48X-23.62; r = 0.825; P = 0.0009), vessel dilator was the only atrial natriuretic peptide that correlated with survival.
Ackerman
B H
BH
Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, USA.
Wyeth
R P
RP
Soulsby
M E
ME
Pappas
A A
AA
Vesely
D L
DL
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D016001:Confidence Intervals; D004285:Dogs; D006439:Hemodynamics; D016014:Linear Models; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology; D011863:Radioimmunoassay
D009320:Atrial Natriuretic Factor