Extended HLA profile of an inbred isolate: the Schmiedeleut Hutterites of South Dakota.
HLA-A, -B, -C, -DR, and -DQ typings of the Schmiedeleut Hutterites of South Dakota were collected as part of an ongoing genetic-epidemiologic study of HLA and fertility. A total of 1,082 individuals, including 852 married adults representative of the reproductive population of this isolate, were characterized for five-locus HLA haplotypes. HLA-A1, A2, A3, and A24 accounted for 75% of observed HLA-A alleles and HLA-B27, B35, B51, and B62 accounted for 55% of observed HLA-B alleles. S-leut Hutterites are derived from 68 or fewer ancestors. However, only 48 ancestral HLA haplotypes were observed and nine of these accounted for over 52% of the observed haplotypes. Measures of two-locus linkage disequilibrium derived from these haplotypes indicated that one-third to half of the observed HLA-A/B, B/DR, and A/DR allele combinations exhibited highly statistically significant linkage disequilibrium. Allele and haplotype frequencies did not differ between males and females. Recombination rates of 0.004% and 0.005% between HLA-A and -C and between HLA-B and -DR, respectively, were observed. This HLA profile points out a paucity of HLA alleles and haplotypes in this population and marked linkage disequilibrium among the HLA alleles that are present.
Dawson
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Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106-4945, USA.
Ober
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C
Kostyu
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D000483:Alleles; D002835:Christianity; D003241:Consanguinity; D005006:Ethnicity / Q000235:genetics*; D005060:Europe / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D011995:Recombination, Genetic / Q000235:genetics; D012494:Sampling Studies; D013023:South Dakota
D006680:HLA Antigens