Individualized gonadotropin regimens for follicular stimulation in macaques during in vitro fertilization (IVF) cycles.
Follicular stimulation was compared in macaques receiving sequential gonadotropin treatment which was terminated after seven, eight, or nine days depending on the time required to attain preselected criteria of follicular maturation. Although estradiol levels and follicle sizes varied, the number of follicles and oocytes/animal, oocyte nuclear maturity, IVF rates and progesterone levels during the luteal phase were similar among groups. Reducing the duration of gonadotropin treatment to individualize follicular stimulation regimens does not compromise follicle or gamete quality.
Zelinski-Wooten
M B
MB
Division of Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton 97006, USA.
Alexander
M
M
Christensen
C L
CL
Wolf
D P
DP
Hess
D L
DL
Stouffer
R L
RL
D000818:Animals; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000662:veterinary*; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D007314:Insemination; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D008597:Menstrual Cycle; D009865:Oocytes / Q000187:drug effects; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D011863:Radioimmunoassay; D013997:Time Factors
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone