Role of aliphatic acids in the biosynthesis of vermiculin in penicillium vermiculatum.
The diolode macrolide vermiculin (1) together with the three unsaturated aliphatic ketoacids vermiculinic (2), vermiculic (3) and 4-deoxovermiculic acid (4) were isolated from the cultivation broth of Penicillium vermiculatum. Biotransformation of 2 and 3 with growing and resting cells of P. vermiculatum was studied. We suppose, that 2 which is formed from 3, is the ultimate progenitor of 1.
Proksa
B
B
Slovak Technical University, Faculty of Chemistry, Department of Biochemical Technology, Bratislava.
Fuska
J
J
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001711:Biotransformation; D003470:Culture Media; D007651:Keto Acids / Q000378:metabolism*; D007783:Lactones / Q000378:metabolism; D010407:Penicillium / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D007651:Keto Acids; D007783:Lactones; C009650:vermiculine