A Drosophila E(spł) gene is "neurogenic" in Xenopus: a green fluorescent protein study.
A Drosophila Enhancer of split [E(spl)] bHLH protein, m delta, was misexpressed in Xenopus embryos along with green fluorescent protein (GFP) as a lineage label. The Drosophila protein translocated to the nucleus of Xenopus cells and led to neural hypertrophy in the GFP-labeled dorsal ectoderm, a phenotype similar to that caused by the misexpression of activated Xotch. Our data indicate a strong conservation in E(spl)bHLH function in the Notch signaling pathway of flies and vertebrates.
Tannahill
D
D
Department of Anatomy, University of Cambridge, England.
Bray
S
S
Harris
W A
WA
D000818:Animals; D004330:Drosophila; D004742:Enhancer Elements, Genetic / Q000235:genetics; D005453:Fluorescence; D009424:Nervous System Physiological Phenomena; D014981:Xenopus / Q000235:genetics* / Q000502:physiology