The use of a mouse model in the study of Helicobacter sp.-associated gastric cancer.
OBJECTIVE
Long-term infection with Helicobacter pylori and the associated gastritis is now thought to cause a predisposition to gastric cancer through cellular changes resulting from inflammatory damage or because of direct effects of the bacterium. MICE AS MODELS FOR H. PYLORI-ASSOCIATED GASTRIC CANCER: Long-term infection of conventional Swiss mice with either H. felis or H. heilmannii results in atrophic gastritis. Infection of specific pathogen-free Balb/c mice results in the development of lesions similar to H. pylori-associated low-grade B-cell gastric lymphomas.


CONCLUSIONS
H. pylori-infected mice appear to be excellent models for the study of tumours induced by this bacterium.
Lee
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School of Microbiology and Immunology, University of New South Wales, Sydney, Australia.
D000818:Animals; D004195:Disease Models, Animal; D005757:Gastritis, Atrophic / Q000382:microbiology / Q000473:pathology; D016998:Helicobacter / Q000472:pathogenicity*; D016481:Helicobacter Infections / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D016480:Helicobacter pylori / Q000472:pathogenicity; D007114:Immunization; D016393:Lymphoma, B-Cell / Q000382:microbiology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D013274:Stomach Neoplasms / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control