[An attempt to use enalapril in arterial hypertension in patients with juvenile obesity].
Clinical efficacy of enalapril, a drug belonging to a group of angiotensin-converting enzyme inhibitors, was studied in patients with pubertal juvenile dyspituitarism (juvenile obesity) coursing with arterial hypertension. A reactive increase of plasma renin activity and reduced concentration of plasma aldosterone were revealed. The drug was characterized by a pronounced hypotensive effect. No negative effects on the blood lipid spectrum or carbohydrate metabolism were observed. The study showed that enalapril may be a drug of choice in the treatment of the hypertensive syndrome in patients with juvenile obesity.
Malygina
E V
EV
Gerasimov
G A
GA
Atamanova
T M
TM
D000293:Adolescent; D000450:Aldosterone / Q000097:blood; D004656:Enalapril / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D009765:Obesity / Q000097:blood / Q000150:complications*; D012083:Renin / Q000097:blood; D013577:Syndrome
D000450:Aldosterone; D004656:Enalapril; D012083:Renin
Opyt primeneniia énalaprila pri arterial'noĭ gipertenzii u bol'nykh iunosheskim ozhireniem.