[Antiphospholipid syndrome and the pneumologist].
The antiphospholipid syndrome (APS) is usually defined by the association of a clinical manifestation (venous or arterial thrombosis or miscarriage) with the presence of antiphospholipid antibodies (lupus anticoagulant and/or anticardiolipin antibodies). It frequently occurs in the course of systemic lupus erythematosus but is also encountered as a "primary" disease. APS is responsible for diverse respiratory manifestations. Pulmonary embolism is common. The site of the causal venous thrombosis is frequently unusual. Pulmonary hypertension may be a consequence of repeated embolism or may belong to the primary idiopathic variety. Pulmonary manifestations may also result from left-sided heart failure due to mitral or aortic valve abnormalities, myocardial infarction or a specific myocardiopathy. APS is probably involved in the occurrence of some cases of adult respiratory distress syndrome. Long term secondary prevention of recurrent thrombosis is a central point in the management of APS.
Piette
J C
JC
Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Cacoub
P
P
Karmochkine
M
M
Godeau
P
P
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D005260:Female; D006349:Heart Valve Diseases / Q000150:complications; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000209:etiology*; D013927:Thrombosis / Q000209:etiology
Le syndrome des antiphospholipides et le pneumologue.