[Somatostatin receptor scintigraphy in medullary thyroid carcinomas, GEP and carcinoid tumors].
For this study, 24 patients with medullary thyroid cancer (MTC) and 10 with carcinoid-/GEP-tumours underwent scintigraphy with 123I-Tyr3-octreotide or 111In-DTPA-D-Phe1-octreotide (Octreoscan) or 99mTc-V-DMSA. Calcitonin and CEA were elevated in MTC patients, the other had tumour lesions on CT. Octreoscan-scintigraphy was positive in 68% of all suspicious cases. On the other hand, 123I-Tyr3-octreotide showed only rarely positive results. 99mTc-V-DMSA-scans in MTC patients were positive in 23%. Liver metastases could be seen only with Octreoscan in the non-MTC-group. These results showed better sensitivity of 111In-labelled octreotide.
Eising
E G
EG
Klinik und Poliklinik für Nuklearmedizin, Universität-GH-Essen, FRG.
Farahati
J
J
Bier
D
D
Knust
E J
EJ
Reiners
C
C
D000328:Adult; D000368:Aged; D002116:Calcitonin / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging*; D018276:Carcinoma, Medullary / Q000000981:diagnostic imaging* / Q000556:secondary; D005189:False Positive Reactions; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000031:analogs & derivatives; D015609:Organotechnetium Compounds; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000032:analysis*; D012680:Sensitivity and Specificity; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*
D002272:Carcinoembryonic Antigen; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D017481:Receptors, Somatostatin; C071632:SDZ 215-811; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004369:Pentetic Acid; D002116:Calcitonin; D004113:Succimer; D015282:Octreotide
Somatostatinrezeptor-szintigraphie bei medullären Schilddrüsenkarzinomen, GEP-Tumoren und Karzinoiden.