Regulators of cell death.
A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic pathway of cellular suicide that appears to be common to all multicellular animals. A related protein that promotes cell death, Bax, wrestles with Bcl-2 through conserved motifs, BH1 and BH2, establishing a set point for these deaths. In Bcl-2-deficient mice, the ratio of these molecules is reset, resulting in massive cell death in several cell types.
Korsmeyer
S J
SJ
Department of Medicine and Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, Saint Louis, MO 63110, USA.
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics; D004267:DNA Viruses / Q000235:genetics; D008322:Mammals / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D008969:Molecular Sequence Data; D005810:Multigene Family; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D051028:bcl-2-Associated X Protein
C494827:Bax protein, mouse; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D011993:Recombinant Fusion Proteins; D051028:bcl-2-Associated X Protein