[Discovery of a new gene frequently inactivated in human cancers: protein p16, a cell cycle regulator].
Comprehension of cell cycle regulation mechanisms progressed very quickly the past few years. The last discovery concern a known gene, MTS1 (Multiple Tumor suppressor), encoding a protein of M(r) 16K, intrinsic component of the cell cycle machinery. p16 protein inhibits an enzyme called CDK4 (cyclin-dependent kinase 4) which is a kinase implicated in the control of cell proliferation between the G1 and S phases. Now, a team reported that MTS1 gene is frequently inactivated in a wide variety of human cancers. This important finding will provide a new link between cell cycle control and oncogenesis, if MTS1 is proved to be a classic tumor suppressor gene.
Bressac-de Paillerets
B
B
Service d'immunologie moléculaire, institut Gustave-Roussy, Villejuif, France.
D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005809:Genes, Regulator; D016147:Genes, Tumor Suppressor; D006801:Humans; D009154:Mutation
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16
Découverte d'un nouveau gène fréquemment inactivé dans les cancers humains: protéine p16, régulateur du cycle cellulaire.