Modulation of endothelin receptor expression in human vascular smooth muscle cells by interleukin-1 beta.
Endothelin may play a role in atherosclerosis as it causes smooth muscle cell proliferation and its levels are elevated in patients with atherosclerosis. We report that interleukin-1 beta is a potent inducer of endothelin receptor expression in cultured human vascular smooth muscle cells. The effect is dose- and time-dependent and is due to an increase in receptor number. Endothelin receptor mRNA levels are also elevated. Interleukin-1 beta is a major regulator of endothelin release so, together with its effects on endothelin receptors, it may be responsible for a generalized activation of the endothelin system in diseased vessels.
Newman
P
P
Thrombosis Research Institute, London, UK.
Kakkar
V V
VV
Kanse
S M
SM
D001011:Aorta; D002455:Cell Division; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D017466:Receptors, Endothelin / Q000235:genetics / Q000378:metabolism*
D016232:Endothelins; D007375:Interleukin-1; D012333:RNA, Messenger; D017466:Receptors, Endothelin