A preliminary exploration of the relationship between tumour necrosis factor (TNF) and monocytic in vitro production of interleukin-1 (IL-1) and internal organ dysfunction in severely burned patients.
Biological assays were adopted in this study to examine the changes in serum tumour necrosis factor (TNF) activity and blood monocytic in vitro production of interleukin 1 (IL-1) in 24 severely burned patients. The myocardial and hepatic enzymes (which included aspartate aminotransferase (AST), creatine kinase (CPK), lactate dehydrogenase (LDH), alpha hydroxybutyric dehydrogenase (alpha-HBDH) and alanine amino-transferase (ALT) and some indices of biochemical metabolism (including lactic acid (LA), total protein (TP), albumin (Alb) and colloid osmotic pressure (COP)) were simultaneously measured. The results showed an evident increase in serum TNF activity and a decrease in in vitro production of IL-1 postburn; all the changes in TNF and IL-1 were correlated significantly with those of myocardial and hepatic enzymes in MOF patients. Furthermore, there were marked fever, hypoproteinaemia, tissue ischaemic and hypoxic symptoms such as hyperlacticaemia, and signs reflecting tissue hypercatabolic states. These all suggested that TNF and IL-1 might play important roles in the development of MOF.
Liu
X S
XS
Institute of Burn Research, Southwestern Hospital, Chongqing, Sichuan, PR China.
Yang
Z C
ZC
Luo
Z H
ZH
Huang
W H
WH
Li
A
A
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002056:Burns / Q000097:blood* / Q000150:complications*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood* / Q000209:etiology*; D000637:Transaminases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D007770:L-Lactate Dehydrogenase; D000637:Transaminases; D003402:Creatine Kinase