Adenosine kinase-deficient mutant of Saccharomyces cerevisiae.
A cordycepin-resistant mutant strain of Saccharomyces cerevisiae (CD-R2) was found to be deficient in adenosine kinase. This mutant accumulated S-adenosylhomocysteine during growth in the presence of exogenous adenosine and it grew in a pseudohyphal manner in the presence of this nucleotide.
Iwashima
A
A
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
Ogata
M
M
Nosaka
K
K
Nishimura
H
H
Hasegawa
T
T
D000241:Adenosine / Q000378:metabolism; D000248:Adenosine Kinase / Q000235:genetics*; D001711:Biotransformation; D002455:Cell Division / Q000187:drug effects; D003839:Deoxyadenosines / Q000493:pharmacokinetics / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics; D009154:Mutation; D012435:S-Adenosylhomocysteine / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D013831:Thiamine / Q000494:pharmacology
D003839:Deoxyadenosines; D012435:S-Adenosylhomocysteine; D000248:Adenosine Kinase; C058120:cordycepin; D000241:Adenosine; D013831:Thiamine