Comparison of dopexamine hydrochloride, fenoldopam, and procaterol on myocardial nutritional flow in rats.
Myocardial nutritional flow (MNF) was determined using 99mTechnetium-methoxy-isobutyl-isonitrile (99mTc-MIBI) in rats. At 25 nmol.kg-1, dopexamine hydrochloride (DH), fenoldopam, and procaterol increased the uptake rate of 99mTc-MIBI/g myocardium by 80.8 +/- 10.2% (P < 0.01), 44.9 +/- 6.3% (P < 0.05), and 30.2 +/- 5.4% (P < 0.05) respectively. These findings suggested the potential advantages of DH over other dopaminergic agonists in the treatment of coronary disease.
Qin
F Z
FZ
Department of Physiology, Shanxi Medical College, Taiyuan, China.
Gao
Z
Z
Zhao
R R
RR
D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation / Q000187:drug effects*; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology*; D005260:Female; D018818:Fenoldopam / Q000494:pharmacology; D008297:Male; D017265:Procaterol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017256:Technetium Tc 99m Sestamibi
D003287:Contrast Media; D018491:Dopamine Agonists; C046318:dopexamine; D017256:Technetium Tc 99m Sestamibi; D018818:Fenoldopam; D004298:Dopamine; D017265:Procaterol