Synthesis and biological activity of pyrimidobenzodiazepine derivatives. New ring systems: triazolo- and tetrazolo-pyrimido-benzodiazepines.
New triazolo- and tetrazolo-pyrimidobenzodiazepines were synthesized and screened as anti-HIV, anticancer and immunosuppressive agents. Some of the compounds showed immunosuppressive activity, similar to or stronger than that of cyclosporine A.
Długosz
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Department of Organic Chemistry, Medical University, Faculty of Pharmacy, Wrocław, Poland.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001570:Benzodiazepinones; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D013777:Tetrazoles; D014230:Triazoles; D016572:Cyclosporine