Regional and arterial localization of radioactive microparticles after local delivery by unsupported or supported porous balloon catheters.
Catheter-mediated intramural delivery of pharmaceutical agents after angioplasty is a potential method to reduce postangioplasty restenosis. The efficacy of such delivery has been limited both by an incomplete initial intramural deposition of delivered agents and by rapid diffusion of soluble agents from the site of delivery. The local delivery of microparticulate agents results in prolonged retention of material at the delivery site. Accordingly this study was designed to evaluate the complementary issue of the initial delivery efficiency and pattern of localization of microparticles after local catheter-mediated delivery with two types of porous balloons. These two types were a "standard" porous balloon (PB) in which hydraulic pressure both inflated the balloon and infused the agents and a porous balloon with a mechanical undergirding that permitted mechanical expansion (PB/ME) before agent infusion. Radioactive cerium 141-labeled microparticles (11.4 microns diameter) were locally delivered into atherosclerotic rabbit femoral arteries after angioplasty to test the hypothesis that use of the PB/ME apparatus would yield enhanced intramural particle deposition and decreased systemic administration by increased balloon-wall contact before microparticle infusion. Six animals underwent infusion with the PB catheter, and seven animals underwent infusion with the PB/ME catheter. An image of the in vivo particle distribution was obtained with a gamma camera during infusion, immediately after infusion, and 1, 3, and 7 days after infusion. Tissue samples from the artery, periadventitia, thigh, calf, and foot musculature, and liver were obtained at animal death, and retained radioactivity was measured with a well counter.(ABSTRACT TRUNCATED AT 250 WORDS)
Wilensky
R L
RL
Indiana University School of Medicine, Indianapolis, USA.
March
K L
KL
Gradus-Pizlo
I
I
Schauwecker
D
D
Michaels
M B
MB
Robinson
J
J
Carlson
K
K
Hathaway
D R
DR
D000800:Angioplasty, Balloon; D000818:Animals; D001158:Arteries / Q000000981:diagnostic imaging* / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism / Q000628:therapy; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D002565:Cerium Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D015902:Gamma Cameras; D008863:Microspheres; D016062:Porosity; D011817:Rabbits; D011877:Radionuclide Imaging; D012008:Recurrence; D013997:Time Factors; D014018:Tissue Distribution
D002565:Cerium Radioisotopes