title: [Muscle-specific changes in free latissimus dorsi transplantation in the rat model].
abstract: The aim of this study is to gain further knowledge concerning the regeneration of reinnervated, freely transplanted muscles. Therefore, we used a rat model, consisting of eight rats per group, in which the latissimus dorsi muscle was transplanted orthotopically, after a period of time of two and twelve weeks harvested, then evaluated histologically and enzyme-histochemically. As controls we used a group of non-operated muscles. At date of removal, the patency of the vascular anastomoses was checked clinically and histologically. Additionally, electrophysiological measurements and conventional and enzyme-histochemical histologies were performed. Two weeks after the free neurovascular flap transplantation, the muscle was not innervated yet, histologically a dissolved pattern of type 1 and type 2 muscle fibers was found. After twelve weeks of time, the muscles were reinnervated again, muscle contraction was positive after electrical stimulation and the typical pattern of fibers was reestablished.
authors.affiliation: Klinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinischen Hochschule Hannover am Krankenhaus Oststad.
authors.forename: M H
authors.initials: MH
authors.lastname: Becker
authors.forename: F
authors.initials: F
authors.lastname: Lassner
authors.forename: F
authors.initials: F
authors.lastname: Dagtekin
authors.forename: G F
authors.initials: GF
authors.lastname: Walter
authors.forename: A
authors.initials: A
authors.lastname: Berger
mesh_terms: D000818:Animals; D001415:Back; D006651:Histocytochemistry; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000098:blood supply / Q000201:enzymology / Q000294:innervation / Q000637:transplantation*; D051381:Rats; D011917:Rats, Inbred Lew; D012038:Regeneration; D013524:Surgical Flaps; D014654:Vascular Patency
vernacular_title: Muskelspezifische Veränderungen bei der freien Latissimus dorsi-Transplantation im Rattenmodell.