Tissue-culture invasion: fact or artefact?
Although widely used, tissue-culture assays cannot be exact models of the conditions that are met in vivo by pathogenic bacteria. However, recent studies of specific mutants suggest that the model is good for highly invasive bacteria, but it remains to be seen if this is true for weakly invasive bacteria.
Miller
V L
VL
University of California, Los Angeles, Dept. of Microbiology and Molecular Genetics 90024-1489, USA.
D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001422:Bacterial Adhesion; D018407:Bacterial Physiological Phenomena; D002478:Cells, Cultured / Q000382:microbiology*; D003584:Cytological Techniques; D006801:Humans