[Changes in the rate of protein biosynthesis in the organs of mice under the action of the delta sleep-inducing peptide and psychoemotional stress].
The effects of delta-sleep-inducing peptide (DSIP) and its analogs (ID-6 and ID-12) on the protein synthesis rate in the mouse brain, liver, and spleen were studied with special reference to mechanisms underlying the adaptogenic action of DSIP. Time-related changes of the protein synthesis rate were estimated in the mouse organs after a single intraperitoneal injection of the peptide (120 mg/kg body weight) and the psycho-emotional stress with or without preliminary (1 h before) injection of the peptide. After DSIP administration, the protein biosynthesis was activated and the dynamics of stress-induced changes of biosynthesis were modified. The data obtained suggest that the mechanisms underlying the DSIP adaptogenic action involve its modulatory effect on the regulatory system of protein biosynthesis.
Rikhireva
G T
GT
Sokolova
I S
IS
Rylova
A V
AV
Kopylovskiĭ
S A
SA
Mikhaleva
I I
II
Prudchenko
I A
IA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002250:Carbon Radioisotopes; D003701:Delta Sleep-Inducing Peptide / Q000031:analogs & derivatives / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D014176:Protein Biosynthesis; D011506:Proteins / Q000187:drug effects*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013315:Stress, Psychological / Q000378:metabolism*
D002250:Carbon Radioisotopes; D046911:Macromolecular Substances; D011506:Proteins; D003701:Delta Sleep-Inducing Peptide
Izmeneniia skorosti biosinteza belkov v organakh mysheĭ pri deĭstvii del'ta-son-indutsiruiushchego peptida i psikhoémotsional'nogo stressa.