Chemical incompatibility between procainamide hydrochloride and glucose following intravenous admixture.
The chemical reaction between procainamide hydrochloride and glucose following admixture to glucose infusion has been investigated. Substantial amounts (10-15% after 10 h at room temperature) of the procainamide is lost with the formation of a mixture of the corresponding alpha- and beta-glucosylamines. The chemical identity of the latter compounds was confirmed by 13C and 1H nuclear magnetic resonance spectroscopy.
Sianipar
A
A
School of Pharmacy, Curtin University of Technology, Perth, Australia.
Parkin
J E
JE
Sunderland
V B
VB
D002851:Chromatography, High Pressure Liquid; D003903:Deuterium; D004347:Drug Interactions; D005944:Glucosamine / Q000737:chemistry / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007262:Infusions, Intravenous; D009682:Magnetic Resonance Spectroscopy; D011342:Procainamide / Q000008:administration & dosage / Q000737:chemistry*
D003903:Deuterium; D005947:Glucose; D011342:Procainamide; D005944:Glucosamine