title: Determination of oxeladin in human plasma by gas chromatography--mass spectrometry.
abstract: A capillary gas chromatographic method with mass-selective detection was developed for the determination of oxeladin in human plasma. Plasma samples (1 mL) were alkalinized and extracted using 5mL of hexane: isoamyl alcohol (99:1). The method was demonstrated to be sensitive (limit of quantitation at 1 ng/mL), linear between 1 and 150 mg/mL, accurate and precise enough (mean error and mean coefficient of variation at the limit of quantitation were 2.3 and 13.3%, respectively) to support pharmacokinetic evaluation of the drug at doses down to 30 mg.
authors.affiliation: Laboratoire de Chimie Analytique et de Spectrométrie de Masse, Faculté de Pharmacie, Clermont Ferrand, France.
authors.forename: C
authors.initials: C
authors.lastname: Lartigue-Mattei
authors.forename: M J
authors.initials: MJ
authors.lastname: Galmier
authors.forename: J L
authors.initials: JL
authors.lastname: Chabard
authors.forename: E
authors.initials: E
authors.lastname: Beyssac
authors.forename: J M
authors.initials: JM
authors.lastname: Aiache
mesh_terms: D000996:Antitussive Agents / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D010654:Phenylbutyrates / Q000097:blood*; D014299:Trimipramine / Q000097:blood
chemical_list: D000996:Antitussive Agents; D010654:Phenylbutyrates; D014299:Trimipramine; C005461:oxeladin