title: [Interferon production in peripheral blood cells of patients with pulmonary mycobacterial disease].
abstract: Production of interferon (IFN)-alpha and IFN-gamma were examined in 31 patients with acute tuberculosis, 12 patients with atypical mycobacterial disease. IFN production was examined in cultures of unseparated fresh whole blood. Production of IFN-alpha was induced by hemagglutinating virus of Japan and production of IFN-gamma was induced by PHA. Patients with mycobacterial disease produced significantly less IFN-alpha than healthy subjects. In patients with acute tuberculosis, effective chemotherapy for 2 months restored IFN-alpha production. Patients produced less IFN-gamma than healthy subjects, but the difference was not significant. Patients with high serum CRP levels tended to produce little IFN-alpha. These results suggest that measurement of IFN production is useful for immunological evaluation of patients with mycobacterial disease.
authors.affiliation: Department of Internal Medicine, National Sanatorium, Minami-Okayama Hospital, Okayama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tada
authors.forename: S
authors.initials: S
authors.lastname: Kawahara
authors.forename: A
authors.initials: A
authors.lastname: Tamaoki
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: C
authors.initials: C
authors.lastname: Okada
authors.forename: Y
authors.initials: Y
authors.lastname: Mishima
authors.forename: R
authors.initials: R
authors.lastname: Soda
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Kibata
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001773:Blood Cells / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
chemical_list: D016898:Interferon-alpha; D007371:Interferon-gamma