[Prophylactic antibiotic therapy with amoxicillin-clavulanic acid in oropharyngeal surgery].
The present paper shows the results of a randomized, prospective trial carried out on 170 patients undergoing elective surgery for oropharyngeal cancer. These patients were distributed in two groups that received a prophylactic therapy with amoxicillin and clavulanic acid, for 24 hours and 5 days, respectively. Comparing results of short-term and long-term prophylaxis. Among patients undergoing only total or partial laryngectomies, no differences between both groups were found. Among patients who already had a tracheostomy, the rate of local infection was higher in the short-time group. Duration of prophylaxis in high-risk surgery, such as that requiring flap reconstruction, needs further investigation.
Navarro
M
M
Servicio de ORL. Hospital Gregorio, Marañón, Madrid.
Scola
E
E
Scola
B
B
Ortiz
P
P
Martínez
T
T
Vega
M F
MF
D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D006801:Humans; D007825:Laryngectomy; D009959:Oropharyngeal Neoplasms / Q000601:surgery*; D011292:Premedication; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors; D014140:Tracheotomy; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D000658:Amoxicillin
Antibioterapia profiláctica con amoxicilina-clavulánico en cirugía orofaringolaríngea.