Hypoglycemia in pregnancy secondary to a non-islet cell tumor of the pleura and ectopic insulin-like growth factor II hormone production.
BACKGROUND
In nondiabetic women, pregnancy alone rarely causes clinical hypoglycemia. Non-islet cell tumors have recently been shown to be associated with the production of insulin-like growth factor II (IGF-II) and a paraneoplastic syndrome resulting in hypoglycemia. A case report and review of pathophysiologic mechanisms involved is presented.


METHODS
A 38-year-old multigravida presented suffering from clinical and biochemical hypoglycemia, which was found to be secondary to a mesothelioma of the pleura and ectopic IGF-II production. Tumor resection was performed during the 13th gestational week. The mother became euglycemic immediately after the surgery and remained asymptomatic. Clinical indicators of pregnancy and an ultrasound scan after the surgery were consistent with a normal viable fetus.


CONCLUSIONS
Symptomatic hypoglycemia and other medical conditions occurring during pregnancy require immediate diagnosis and treatment. In addition to the more common causes, documented cases of medical conditions due to paraneoplastic syndromes of ectopic hormone production during pregnancy have been described. This case establishes the non-islet cell tumor with IGF-II-induced hypoglycemia as another such syndrome to be considered when evaluating hypoglycemia in pregnancy.
Schweichler
M
M
Division of Endocrinology, Brown University, Providence, Rhode Island, USA.
Hennessey
J V
JV
Cole
P
P
Perdue
J F
JF
Le Roith
D
D
D000328:Adult; D005260:Female; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008654:Mesothelioma / Q000150:complications / Q000378:metabolism*; D009384:Paraneoplastic Endocrine Syndromes; D010298:Parity; D010997:Pleural Neoplasms / Q000150:complications / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood
D006729:Hormones, Ectopic; D007335:Insulin-Like Growth Factor II