[Rates of physical development as a marker of the quality of metabolic control in children and adolescents with diabetes mellitus].
Physical development of 710 children and adolescents with insulin-dependent diabetes mellitus (IDDM) was studied over time. The patients were divided into 3 groups: with growth rate above the 25th percentile of the age norm, with growth rate below the 10th percentile of the norm, and with growth rates between the 10th and 25th percentiles of age norm. Analysis showed that (a) the presence of manifest decompensation (HbA1) higher than 12%, frequent ketoacidosis episodes is a factor of high risk of reduction of physical development rate in children and adolescents with IDDM; (b) the mean statistical rates of diabetic adolescents growth are characterized by delayed (by 1 to 2 years vs. the norm) pubertal growth "skip", and this growth skip in the patients is more levelled and stretched in time, and in some cases is virtually nor manifest; (c) if good compensation is attained and maintained after previous prolonged decompensation, compensating growth rates may develop in patients of both sexes both in childhood and adolescence.
Lebedev
N B
NB
D000293:Adolescent; D015415:Biomarkers; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D016883:Diabetic Ketoacidosis / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012741:Sexual Maturation / Q000502:physiology*
D015415:Biomarkers
Tempy fizicheskogo razvitiia kak marker kachestva metabolicheskogo kontrolia u deteĭ i podrostkov s sakharnym diabetom.