title: [Frequency of antibiotics-associated colitis in hospitalized patients in 1974-1991 in "Comprehensive Hospital Drug Monitoring", Bern/St. Gallen].
abstract: In 3 divisions of internal medicine of teaching hospitals of the Comprehensive Hospital Drug Monitoring (CHDM) Foundation Bern/St Gallen, 42,920 patients consecutively admitted between 1974-1991 were investigated for adverse drug reactions. Of these 16,150 patients (38%) had received at least one systemically administered antibacterial drug during the hospital stay. Antibiotic-associated colitis included the following diagnoses: pseudomembranous colitis, hemorrhagic colitis and milder forms of colitis. We collected the data of these patients by searching for all diagnoses which might represent antibiotic-associated colitis (from the list of WHO adverse drug reaction terminology). 9 individual patients with one episode of probable antibiotic-associated colitis were found. In 5 of these cases, only one drug given during the hospital stay seemed to be implicated. An additional 32 patients were admitted with antibiotic-associated colitis in relation to treatment with the same groups of drugs before hospital admission. Based on the exposure pattern of the 9 patients with antibiotic-associated colitis compared to all patients exposed during hospital stay, we estimated the following frequencies related to the drug groups with at least 1,000 patients exposed: for all antibacterial chemotherapeutics 0.6/1000 (0.25-1.06); all penicillins 0.6/1000 (0.22-1.32), for benzyl-, phenoxy-, ureido-, isoxazolyl penicillins and methicillin 2.0/1000 (0.42-5.92) and aminopenicillin or analogues, with or without clavulanic acid 0.6/1000 (0.18-1.35). For cephalosporins the frequency is 1.4/1000 (0.17-5.12). Under sulfonamides combined with trimethoprim or related substances (5077 exposed patients) and fluoroquinolones (1043 exposed patients) no case was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Medizinische Klinik, Zieglerspital Bern.
authors.forename: D
authors.initials: D
authors.lastname: Zehnder
authors.forename: U P
authors.initials: UP
authors.lastname: Künzi
authors.forename: R
authors.initials: R
authors.lastname: Maibach
authors.forename: M
authors.initials: M
authors.lastname: Zoppi
authors.forename: F
authors.initials: F
authors.lastname: Halter
authors.forename: K A
authors.initials: KA
authors.lastname: Neftel
authors.forename: U
authors.initials: U
authors.lastname: Müller
authors.forename: R L
authors.initials: RL
authors.lastname: Galeazzi
authors.forename: T
authors.initials: T
authors.lastname: Hess
authors.forename: R
authors.initials: R
authors.lastname: Hoigné
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects; D003092:Colitis / Q000139:chemically induced*; D016001:Confidence Intervals; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000009:adverse effects; D013557:Switzerland
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins
vernacular_title: Die Häufigkeit der Antibiotika-assoziierten Kolitis bei hospitalisierten Patienten der Jahre 1974-1991 im "Comprehensive Hospital Drug Monitoring" Bern/St. Gallen.