Effect of atrial and ventricular activation interval on hemodynamics during atrioventricular and ventriculoatrial pacing: determination from pressure-volume loops in dogs.
To determine the effect of relative timing of atrial and ventricular activation on hemodynamic indices, we evaluated pressure-volume loops during pacing at 160 beats/min with various atrioventricular intervals in dogs. End-systolic pressure, end-diastolic volume, and stroke volume were reduced during pacing at atrioventricular intervals of 0 ms, compared with 80 ms. These changes were more significant during pacing at atrioventricular intervals of -50 and -100 ms than at 0 ms. During tachycardia, the abnormal timing of atrial contraction leads to unfavorable hemodynamic change and the degree of the changes are determined by the ventriculoatrial activation interval.
Matsui
Y
Y
Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Iwasaka
T
T
Karakawa
M
M
Takayama
Y
Y
Takashima
H
H
Taniguchi
H
H
Tamura
T
T
Kitashiro
S
S
Sugiura
T
T
Inada
M
M
D000818:Animals; D016275:Atrial Function / Q000502:physiology*; D006328:Cardiac Catheterization; D002304:Cardiac Pacing, Artificial; D004285:Dogs; D004562:Electrocardiography; D006439:Hemodynamics / Q000502:physiology*; D013610:Tachycardia / Q000503:physiopathology*; D016276:Ventricular Function / Q000502:physiology*