[Human parathyroid allotransplantation: comparison of donor grafts].
The authors compared the degrees of cell maturity, antigenicity and secretory function of parathyroid (PTG) tissues from cadavers (C-PTG), 20-28 wk fetus (F-PTG) and PTG adenoma (A-PTG). In A-PTG tissues, clustered or scattered immature cells were observed, but there were none in F-PTG and C-PTG. C-PTG and A-PTG tissues revealed better secretory function than F-PTG. No clear difference was found in HLA class I (ABC) antigen quantity among the three donor PTG tissues, but the amount of HLA class II (DR) antigen in A-PTG and F-PTG were significantly lower than that in C-PTG. The results demonstrate that C-PTG, with better function, and F-PTG, with lower antigenicity, can be used in clinical transplantation. A-PTG is not suitable for clinical transplantation due to their immaturity and possibility of carcinomatous change.
Gao
Z
Z
PUMC Hospital, CAMS, Beijing.
Zhu
Y
Y
Li
D
D
D000236:Adenoma; D016332:Fetal Tissue Transplantation; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D010280:Parathyroid Glands / Q000196:embryology / Q000276:immunology / Q000637:transplantation*; D010281:Parathyroid Hormone / Q000378:metabolism; D010282:Parathyroid Neoplasms; D014019:Tissue Donors; D014184:Transplantation, Homologous
D006684:HLA-DR Antigens; D010281:Parathyroid Hormone