Comparative pathology of mammary tumorigenesis in transgenic mice.
Mammary tumors arise in transgenic mice bearing growth factors, proto-oncogenes, oncogenes and tumor suppressor genes. The tumors arise from hyperplasias. The tumor natural history and histogenesis are oncogene specific. Interactions between oncogenes may impede or accelerate tumorigenesis.
Cardiff
R D
RD
Department of Pathology, School of Medicine, University of California, Davis 95616, USA.
Munn
R J
RJ
D000818:Animals; D016147:Genes, Tumor Suppressor; D006965:Hyperplasia; D008325:Mammary Neoplasms, Experimental / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D009857:Oncogenes