Adjuvant-induced persistent photosensitivity models in guinea pigs. II. Characterization of immunological mechanisms.
The immunological characteristics of our adjuvant-induced persistent photosensitivity (AIPP) guinea pig model were examined. The sensitivity to long-wavelength ultraviolet light (UVA) was transferred with peritoneal exudate cells. Proliferative response was observed in peritoneal exudate cells and lymph node cells concomitantly cultured in the presence of sera that had previously been irradiated with UVA. Cervical lymph nodes of AIPP animals were found to be hypertrophic, and the ratio of major histocompatibility complex (MHC) class II positive cells was increased as compared to that of intact guinea pigs. These results suggest that persistent photosensitivity elicited with UVA is based on cellular autoimmunity. Thus, the AIPP guinea pig model should be useful to study the mechanism of persistent photosensitivity disease in humans.
Ichikawa
H
H
Institute for Advanced Skin Research Inc., Yokohama, Japan.
Soma
T
T
Osaka
T
T
Sato
Y
Y
Fukushima
S
S
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D004195:Disease Models, Animal; D005434:Flow Cytometry; D006168:Guinea Pigs; D016219:Immunotherapy, Adoptive; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D010529:Peritoneal Cavity / Q000473:pathology; D010787:Photosensitivity Disorders / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
D000276:Adjuvants, Immunologic