Serum cytokines in gestational trophoblastic diseases.
Interleukin 1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were assayed by 125I immunoradiometric assay in sera of 42 cases of vesicular mole (VM), 24 cases of choriocarcinoma and 23 normal pregnant women at their first trimester (controls). According to pathologic diagnosis and serial serum hCG beta assays, the cases with VM and choriocarcinoma were subdivided into remission and progressive tumor groups. The progressive tumor groups--both VM and choriocarcinoma--showed marked elevations of serum IL-1 beta, IL-6 and TNF alpha. For choriocarcinoma in remission this elevation was considerably less pronounced. The VM cases in remission had only a slight increase of the mean serum IL-6 value and none of the cases had elevated IL-1 beta or TNF values. These results may indicate that serum IL-1 beta and TNF-alpha assays are valuable biomarkers in the differential diagnosis of gestational trophoblastic disease (GTD). Moreover, normal values of these cytokines may rule out high-risk GTD, whereas markedly elevated values may indicate poor prognosis.
Shaarawy
M
M
Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt.
Darwish
N A
NA
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D002822:Choriocarcinoma / Q000188:drug therapy / Q000276:immunology / Q000601:surgery; D003131:Combined Modality Therapy; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000188:drug therapy / Q000276:immunology / Q000601:surgery; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D011247:Pregnancy; D011863:Radioimmunoassay; D012074:Remission Induction; D014328:Trophoblastic Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery
D014408:Biomarkers, Tumor; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha