Reciprocal IL-1 beta gene expression in medial and lateral hypothalamic areas in SART-stressed mice.
Specific alteration of rhythm of temperature (SART) stress has been found to induce thymic atrophy via activation of the hypothalamus-pituitary-adrenal (HPA) axis. We demonstrate here that SART stress induces increment of IL-1 beta mRNA levels in the medial hypothalamic area (MHA) and decrement of IL-1 beta mRNA levels in the lateral hypothalamic area (LHA). The altered levels of IL-1 beta expression in these loci return to those of non-stressed mice upon cessation of the stress. These data imply that the reciprocal wave of SART stress-induced IL-1 beta gene expression in MHA and LHA may contribute to activation of the HPA axis and the resulting immunological dysfunction.
Tagoh
H
H
Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Nishijo
H
H
Uwano
T
T
Kishi
H
H
Ono
T
T
Muraguchi
A
A
D000818:Animals; D005260:Female; D015870:Gene Expression; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007031:Hypothalamus / Q000502:physiology*; D007375:Interleukin-1 / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D013312:Stress, Physiological / Q000235:genetics* / Q000378:metabolism; D013696:Temperature
D007375:Interleukin-1; D012333:RNA, Messenger