The enhancement of growth of a syngeneic plasmacytoma in BALB/c mice by pristane priming is not due to immunosuppressive effects on antibody-forming cell or mitogen-responsive splenocytes.
The effects of pristane on some immunity parameters in BALB/c mice were studied. The intraperitoneal administration of a single dose of pristane induced a strong inflammatory reaction that lasted longer than 10 days. When mice were immunized with sheep erythrocytes 10 days after pristane administration, the response of hemolytic IgM-forming cells was increased and that of hemolytic IgG-forming cells was decreased; however, the total number of antibody-forming cells did not change. The proliferative response of splenocytes to concanavalin A was increased in mice that received pristane 10 days earlier. Development of the syngeneic NS1 plasmacytoma was enhanced by administration of pristane 2 days or 10 days before tumor transplantation. We concluded that enhancement of plasmacytoma development was not due to immunosuppressive properties of pristane but to other factors such as ascites induction.
Ruiz-Bravo
A
A
Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Spain.
Perez
M
M
Jimenez-Valera
M
M
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens; D009368:Neoplasm Transplantation / Q000276:immunology; D010529:Peritoneal Cavity / Q000166:cytology; D010954:Plasmacytoma / Q000473:pathology*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D013729:Terpenes / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D008934:Mitogens; D013729:Terpenes; C009042:pristane