Late motor involvement in cases presenting as "chronic sensory demyelinating polyneuropathy".
Chronic inflammatory demyelinating polyneuropathy (CIDP) is usually characterized by prominent motor deficits. A pure sensory presentation, labeled chronic sensory demyelinating neuropathy (CSDN), has been reported, but it is unclear if this neuropathy is a distinct clinical and immunologic entity or merely the sensory presentation of the more usual sensorimotor CIDP. We describe 5 patients with what initially appeared to be CSDN; 3 subsequently developed substantial weakness coincident with the electrophysiologic appearance of multifocal motor conduction block. These cases indicate that, in some cases, CSDN may be a transitional clinical stage of CIDP in which the more usual sensorimotor deficits develop later. Immune-based therapy, including intravenous immunoglobulin, was found to be effective in both the pure sensory and sensorimotor types.
Berger
A R
AR
Department of Neurology, Montefiore Medical Center, Bronx, NY 10467, USA.
Herskovitz
S
S
Kaplan
J
J
D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology*; D009431:Neural Conduction; D009443:Neuritis / Q000503:physiopathology / Q000628:therapy; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology* / Q000628:therapy; D012678:Sensation Disorders / Q000503:physiopathology* / Q000628:therapy
D016756:Immunoglobulins, Intravenous