title: Cellular immunity in autoimmune thyroid disease.
abstract: Autoimmune thyroid disease occurs in a genetically susceptible patient after triggering events including bacterial and viral infections, environmental insults, drugs or hormones. These triggering events may break the tolerance to self-antigen, leading to emergence of autoreactive T cells. One or more T cell clones that recognize the self-antigen is(are) assumed to be involved in initiating autoimmune processes. Following this, T cell clones expand and migrate from the peripheral blood into the thyroid gland. Migration of mononuclear cells is controlled by inflammatory cytokines and adhesion molecules. Intrathyroidal T cells may interact with dendritic-like cells, thyrocytes expressed with HLA-DR antigens, B cells and extracellular matrix, resulting in the proliferation of T cells, production of cytokines and autoantibodies. These interactions are also regulated by inflammatory cytokines and adhesion molecules. When the initial immune response is completed, a secondary immune response ensues, that may be of considerable complexity involving reaction of infiltrating T cells to a variety of tissue-specific and tissue-non-specific antigens. These immune responses may contribute to the recurring immunologic activity and maintenance of autoantibody overproduction.
authors.affiliation: First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: N
authors.initials: N
authors.lastname: Matsuoka
authors.forename: S
authors.initials: S
authors.lastname: Nagataki
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D007111:Immunity, Cellular; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology; D013959:Thyroid Diseases / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology
chemical_list: D015815:Cell Adhesion Molecules; D011948:Receptors, Antigen, T-Cell