Clinical significance of creatine kinase isoenzymes for fetal asphyxia in women at labor.
Creatine kinase-brain isoenzyme activity (CK-BB) was measured longitudinally in the serum of 31 pregnant women in the first stage of labor (early and advanced), at delivery, and 1, 6 and 24 h after delivery, in the umbilical cord and in the serum of their neonates on the first day of life. There was no increase in serum CK-BB values of mothers that delivered normally (n = 15) or had an elective cesarean section (n = 5). Pregnant women with signs of fetal distress had an increase in CK-BB levels in the first stage of labor (mean +/- SD 4.5 +/- 4.9 U/l, p < 0.03) and 6 h after delivery (12 +/- 4 U/l, p < 0.0001). Neonates with intrauterine stress also had an increase in their CK-BB to 144 +/- 116 U/l at 6 h of life, in comparison with babies born without signs of stress. It appears that CK-BB during labor and in the first hours of life may be indicative of intrauterine stress.
Andronikou
S
S
Child Health Department, University of Ioannina Medical School, Greece.
Bairaktari
E
E
Vasiliadou
A D
AD
Stefos
T
T
Lolis
D
D
Tsolas
O
O
Lapatsanis
P D
PD
D001238:Asphyxia Neonatorum / Q000201:enzymology*; D002585:Cesarean Section; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D005316:Fetal Distress / Q000201:enzymology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes; D007743:Labor, Obstetric / Q000097:blood; D011247:Pregnancy; D012189:Retrospective Studies; D013997:Time Factors
D007527:Isoenzymes; D003402:Creatine Kinase