title: Therapy of resistant systemic necrotizing vasculitis. Polyarteritis, Churg-Strauss syndrome, Wegener's granulomatosis, and hypersensitivity vasculitis group disorders.
abstract: The systemic necrotizing vasculitides represent a difficult group of diseases from a therapeutic perspective. Even with successful therapy patients often experience a high degree of disease and treatment morbidity. Refractory disease, or that which fails to respond to standard therapy, is particularly challenging. A clinical approach to several vasculitic syndromes is outlined in this article with emphasis given to therapies supported by controlled investigations and those supported by consensus opinion where available.
authors.affiliation: Cleveland Clinic Foundation, Ohio, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Calabrese
authors.forename: G S
authors.initials: GS
authors.lastname: Hoffman
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
mesh_terms: D015267:Churg-Strauss Syndrome / Q000188:drug therapy*; D004351:Drug Resistance; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D010488:Polyarteritis Nodosa / Q000188:drug therapy*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy*