title: [Effects of recombinant human erythropoietin in the treatment of anemia of prematurity].
abstract: 13 premature babies (gestational age 31.1 +/- 0.9 weeks and birth weight 1586 +/- 261 g) were randomly assigned to receive recombinant human erythropoietin (200 U/kg i.v. three times a week during 4 weeks) or no (13 babies) as soon as haematocrit decrease < 30% between second and seventh week (TO). The two groups had similar gestational age, birth weight, Apgar score 1' and 5', O2-therapy, IPPV and volume of packed erythrocytes transfused before TO. Treatment was started at 30 +/- 0.5 days (range 21-42). At TO all subjects had not cardiopulmonary compromission, sepsis, O2-dependence, GMH-IVH > or = 2 degree grade and received iron and Vit. E by i.m. Result were evaluated through determination of hemoglobin, haematocrit, reticulocytes and volume of packed erythrocytes before and on days 7, 14, 21 and 28 of therapy. After rHuEPO the number of reticulocytes increased on days 21 and 28 of therapy (on day 21: 92.4 +/- 34.2 x 1000/L vs. 71.8 +/- 21.0, p < 0.10; on day 28: 116.2 +/- 42.9 vs. 83.8 +/- 23.2, p < 0.05); otherwise the number of transfusion (0.2 +/- 0.4 vs. 1.0 +/- 1.2, p < 0.10) and volume of packed erythrocytes (3.0 +/- 6.3 ml/kg vs. 14.9 +/- 15.9, p < 0.05) were reduced. Serum erythropoietin levels did not change during treatment, probably because, reducing the lowering of hemoglobin, hypoxic stimulus to increase of erythropoietin was suppressed.
authors.affiliation: Unità di Terapia Intensiva Neonatale, Ospedale Di Summa di Brindisi, Italia.
authors.forename: E
authors.initials: E
authors.lastname: Rosati
authors.forename: G
authors.initials: G
authors.lastname: Latini
authors.forename: B
authors.initials: B
authors.lastname: De Mitri
authors.forename: L
authors.initials: L
authors.lastname: Quartulli
authors.forename: P
authors.initials: P
authors.lastname: Caliandro
mesh_terms: D000751:Anemia, Neonatal / Q000097:blood / Q000188:drug therapy*; D001724:Birth Weight; D004906:Erythrocyte Count; D004921:Erythropoietin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005865:Gestational Age; D006400:Hematocrit; D006452:Hemoglobinometry; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D012156:Reticulocytes; D013997:Time Factors
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin
vernacular_title: Effetti della eritropoietina umana ricombinante nel trattamento dell'anemia del pretermine.