title: Acinetobacter spp., saprophytic organisms of increasing pathogenic importance.
abstract: Acinetobacter spp. are Gram-negative non-fermentative bacteria commonly present in soil and water as free-living saprophytes; they are isolated as commensals from skin, throat and various secretions of healthy people. There have been frequent changes in their taxonomy so that their pathogenic role in humans has been understood only recently: Acinetobacter has emerged as an important nosocomial pathogen involved in outbreaks of hospital infections. This ubiquitous organism can be recovered from the hospital environment, from colonized or infected patients or from staff (hand carriage). Acinetobacter as an opportunistic pathogen is involved in nosocomial urinary tract infections, bacteremia, wound and burn infections. Its predominant role is observed in nosocomial pneumonia, particularly in fan-associated pneumonia. Acinetobacters are responsible for difficult-to-treat infections due to their frequent multiple resistance to major antibiotics available for the treatment of nosocomial infections. Various mechanisms of resistance to beta-lactams and aminoglycosides have been recognized in these bacteria. Combination therapy is usually recommended for the treatment of nosocomial infections. The increasing pathogenic importance of Acinetobacter spp. and the increasing frequency of hospital outbreaks of acinetobacter infections has made the development of reliable typing methods imperative. Beside conventional "phenotypic" methods (serology, phage typing), genotypic systems (ribotyping, plasmid profiles, pulse-field gel electrophoresis) are currently advancing.
authors.affiliation: Bichat-Claude Bernard University-Hospital, Department of Microbiology, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Bergogne-Bérézin
mesh_terms: D000150:Acinetobacter / Q000145:classification / Q000187:drug effects / Q000472:pathogenicity*; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D000818:Animals; D004352:Drug Resistance, Microbial; D006801:Humans