title: Sequence-dependent bending propensity of DNA as revealed by DNase I: parameters for trinucleotides.
abstract: Structural parameters characterizing the bending propensity of trinucleotides were deduced from DNase I digestion data using simple probabilistic models. In contrast to dinucleotide-based models of DNA bending and/or bendability, the trinucleotide parameters are in good agreement with X-ray crystallographic data on bent DNA. This improvement may be due to the fact that the trinucleotide model incorporates more sequence context information than do dinucleotide-based descriptions.
authors.affiliation: International Centre for Genetic Engineering and Biotechnology, (ICGEB), Trieste, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Brukner
authors.forename: R
authors.initials: R
authors.lastname: Sánchez
authors.forename: D
authors.initials: D
authors.lastname: Suck
authors.forename: S
authors.initials: S
authors.lastname: Pongor
mesh_terms: D001483:Base Sequence; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D003850:Deoxyribonuclease I / Q000378:metabolism*; D005069:Evaluation Studies as Topic; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*
chemical_list: D009838:Oligodeoxyribonucleotides; D004247:DNA; D003850:Deoxyribonuclease I