title: Administration of testosterone during the follicular phase increased the number of corpora lutea in gilts.
abstract: The effects of 0 (vehicle), 1, 10, or 100 mg of testosterone, administered on d 17 and 18 of the estrous cycle (d 0 = 1st d of estrus), on the number of preovulatory follicles on d 19 or the number of corpora lutea (CL) and blastocysts on d 11 of the subsequent cycle were examined in 82 gilts. The mean number of preovulatory follicles increased (P < .01) in a dose-dependent manner. Likewise, gilts that received 1, 10, or 100 mg of testosterone had more (P < .05) CL than gilts treated with vehicle. The mean number of blastocysts increased (P = .06) in gilts receiving 1 mg of testosterone but decreased (P < .05) in gilts treated with 10 mg of testosterone compared with gilts receiving vehicle. Similarly, recovery rates of blastocysts decreased (P < .05) in gilts treated with 10 or 100 mg of testosterone relative to gilts administered 0 or 1 mg of testosterone. Plasma concentrations of testosterone and estradiol increased (P < .05) 2 h following administration of 1 mg of testosterone on d 17 of the estrous cycle. These results indicate that although the 10- and 100-mg dosages of testosterone were detrimental to blastocyst survival, the 1-mg dosage increased synthesis of estradiol and the number of CL and d-11 blastocysts.
authors.affiliation: Department of Animal Science, Ohio State University, Columbus 43210.
authors.forename: H
authors.initials: H
authors.lastname: Cárdenas
authors.forename: W F
authors.initials: WF
authors.lastname: Pope
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D003338:Corpus Luteum / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry; D005498:Follicular Phase / Q000187:drug effects* / Q000502:physiology; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D013552:Swine / Q000502:physiology*; D013739:Testosterone / Q000032:analysis / Q000097:blood / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D004958:Estradiol