title: [Women at high risk for breast cancer: can we define a group of women in France who could participate in a prevention trial?].
abstract: Each year, more than 10,000 women die of breast cancer in France. Whatever the prevention measures adopted, they must be considered with undivided attention. Three factors are associated with an elevated risk of breast cancer: to be 50 or over, a family history of breast cancer affecting the mother and at least one sister (particularly in the event of early-onset breast cancer), or a personal history of benign proliferative breast disease with cellular atypia. High risk subjects can be defined as those who regroup these three factors, but this definition only applies to a population of 800 women in the entire French population. By broadening the definition of high risk subjects to include those aged 50 or over, who have a benign proliferative breast disease with cellular atypia, and a family history defined as "at least two cases if it concerns their mother or sister; or at least three cases, if it concerns aunts, grandmothers or daughters", the number of women would rise to 40,000 in France. In this high risk population, one in every two women will develop a breast cancer during the next 30 years. We consider therefore it ethically feasible to propose a prevention trial to this group of women in France.
authors.affiliation: INSERM, Unité 351, Institut Gustave Roussy, Villejuif.
authors.forename: M G
authors.initials: MG
authors.lastname: Lê
authors.forename: G
authors.initials: G
authors.lastname: Plu-Bureau
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004992:Ethics, Medical; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D018579:Patient Selection; D011322:Primary Prevention; D018570:Risk Assessment; D012307:Risk Factors
vernacular_title: Les femmes à haut risque de cancer du sein: peut-on définir en France un groupe de femmes qui pourraient participer à un essai de prévention?