A variant t(14;17) in acute promyelocytic leukemia. Positive response to retinoic acid treatment.
We present a case of acute promyelocytic leukemia (APL) carrying an atypical translocation involving chromosomes 14 and 17. This translocation could be considered a variant of the APL-specific t(15;17). Positive response to retinoic acid treatment suggests molecular rearrangement of retinoic acid receptor alpha.
Cigudosa
J C
JC
Department of Genetics, University of Navarra, Pamplona, Spain.
Calasanz
M J
MJ
Odero
M D
MD
Marín
J
J
Bengoechea
E
E
Gullón
A
A
D000328:Adult; D016026:Bone Marrow Transplantation; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D003131:Combined Modality Therapy; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy; D008297:Male; D012074:Remission Induction; D014178:Translocation, Genetic; D014212:Tretinoin / Q000627:therapeutic use*
D014212:Tretinoin