title: Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma.
abstract: We evaluated the harvest product from 47 patients undergoing peripheral blood (BP) stem cell collections for monoclonal plasma cells (PC) using a sensitive immunofluorescence technique. 60% (28/47) had documented tumour cells in the apheresis product. The 32 patients in plateau had a mean of 1.62 x 10(6) PC/l v 74.64 x 10(6) in 15 relapsed patients (P < 0.01). 32% (6/19) of patients without any tumour cells in the initial sample had them detected on a subsequent apheresis sample. In four cases (all treated with GM-CSF) small numbers of tumour cells were detected initially but became undetectable on a subsequent sample.
authors.affiliation: Division of Internal Medicine and Hematology, Mayo Clinic, Rochester, MN 55905.
authors.forename: T E
authors.initials: TE
authors.lastname: Witzig
authors.forename: M A
authors.initials: MA
authors.lastname: Gertz
authors.forename: A A
authors.initials: AA
authors.lastname: Pineda
authors.forename: R A
authors.initials: RA
authors.lastname: Kyle
authors.forename: P R
authors.initials: PR
authors.lastname: Greipp
mesh_terms: D001781:Blood Component Removal; D001804:Blood Transfusion, Autologous; D002452:Cell Count; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D009101:Multiple Myeloma / Q000097:blood* / Q000628:therapy; D014411:Neoplastic Stem Cells; D010950:Plasma Cells; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor