Chyme transport patterns in human duodenum, determined by multiple intraluminal impedancometry.
To get information about the mechanisms involved in chyme transport during the fasting and postprandial states, the novel procedure of multiple intraluminal impedancometry was evaluated in 14 healthy subjects (6 during fasting, 8 after a test meal). All main features of the migrating motor complex (MMC) cycle were determined. During phase II of the MMC cycle and the postprandial period, different transport patterns of chyme, termed bolus transport events (BTEs), were determined. These were 1) simple long-distance propulsive transport (spreading distance > 16 cm), 2) short-distance propulsive transport, and 3) retrograde transport. A significantly lower number of BTEs was recorded during fasting than postprandially. Short-distance propulsive BTEs predominated during fasting (72%), and long-distance propulsive BTEs predominated after the test meal (76%). Retrograde BTEs were recorded during fasting (4%) and postprandially (8%). In the latter state, complex long-distance propulsive BTEs were also observed (5%), consisting of multiple components. A major proportion of gastric contents was found to be continuously transported to jejunum. In conclusion, impedancometry enables us to determine patterns and parameters of chyme transport during fasting and postprandial states.
Nguyen
H N
HN
Department of Internal Medicine III, Aachen University of Technology, Germany.
Silny
J
J
Wüller
S
S
Marschall
H U
HU
Rau
G
G
Matern
S
S
D000328:Adult; D001692:Biological Transport; D004063:Digestion; D004386:Duodenum / Q000378:metabolism* / Q000502:physiology; D004435:Eating; D017097:Electric Impedance; D004594:Electrophysiology / Q000379:methods*; D005260:Female; D005766:Gastrointestinal Contents; D005769:Gastrointestinal Motility; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D016065:Myoelectric Complex, Migrating