title: Ozone exposure has both a priming effect on allergen-induced responses and an intrinsic inflammatory action in the nasal airways of perennially allergic asthmatics.
abstract: Ozone may play a significant role in the exacerbation of airway disease in asthmatics, either by priming the airway mucosa such that cellular responses to allergen are enhanced or by exerting an intrinsic effect on airway inflammation. Previous investigations of nonasthmatic subjects revealed that ozone induces both nasal and bronchial inflammation, suggesting that nasal responses to ozone may be used as a surrogate marker for the effect of this pollutant on bronchial mucosal inflammation. In this study, the effect of exposure to 0.4 ppm ozone on nasal inflammation in 11 allergic asthmatics sensitive to Dermatophygoides farinae was examined. This study was designed such that the effect of ozone exposure on the late-phase reaction to allergen was emphasized, using eosinophil influx and changes in eosinophil cationic protein as principal endpoints. By employing a "split-nose" design, in which allergen was applied to only one side of the nose while saline was applied to the contralateral side, both the effect of ozone on nasal inflammation due to allergen challenge as well as its direct action on non-allergen-challenged nasal tissues was examined. The results reported herein indicate that ozone exposure has both a priming effect on allergen-induced responses as well as an intrinsic inflammatory action in the nasal airways of perennially allergic asthmatics.
authors.affiliation: Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill 27514, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Peden
authors.forename: R W
authors.initials: RW
authors.lastname: Setzer
authors.forename: R B
authors.initials: RB
authors.lastname: Devlin
mesh_terms: D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000032:analysis; D000485:Allergens; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D001985:Bronchial Provocation Tests; D004311:Double-Blind Method; D004804:Eosinophils; D005260:Female; D006801:Humans; D007249:Inflammation; D016209:Interleukin-8 / Q000032:analysis; D007958:Leukocyte Count; D008297:Male; D008925:Mites; D017817:Nasal Lavage Fluid / Q000737:chemistry / Q000166:cytology; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology*; D010126:Ozone / Q000009:adverse effects*; D012221:Rhinitis, Allergic, Perennial / Q000150:complications*; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000418:Albumins; D000485:Allergens; D016209:Interleukin-8; D000515:alpha 1-Antitrypsin; D010126:Ozone