Lichen planus pemphigoides: identification of 180 kd hemidesmosome antigen.
We describe a man with lichen planus pemphigoides. Direct immunofluorescence studies of peribullous skin showed linear deposition of IgG and C3 in the basement membrane zone. Indirect immunofluorescence studies disclosed circulating anti-basement membrane zone antibodies. Immunoelectron microscopy demonstrated binding of antibodies to the hemidesmosomes and lamina lucida. The patient's serum defined only the minor bullous pemphigoid antigen with a molecular weight of 180 kd. These findings suggest the coexistence of lichen planus and bullous pemphigoid in lichen planus pemphigoides.
Tamada
Y
Y
Department of Dermatology, Aichi Medical University, Japan.
Yokochi
K
K
Nitta
Y
Y
Ikeya
T
T
Hara
K
K
Owaribe
K
K
D000368:Aged; D001324:Autoantigens / Q000032:analysis*; D001485:Basement Membrane / Q000276:immunology; D002352:Carrier Proteins; D003094:Collagen; D003176:Complement C3 / Q000032:analysis; D003598:Cytoskeletal Proteins; D003896:Desmosomes / Q000276:immunology*; D000071821:Dystonin; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008010:Lichen Planus / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D016253:Microscopy, Immunoelectron; D008970:Molecular Weight; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D010391:Pemphigoid, Bullous / Q000150:complications* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000276:immunology*; D000097805:Collagen Type XVII
D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003176:Complement C3; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D007074:Immunoglobulin G; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human