Polyoma virus middle T antigen: meddler or mimic?
Polyoma virus middle T antigen duplicates the actions of growth-factor receptors in binding the signalling molecules phosphatidylinositol 3'-OH kinase and Shc. These properties indicate that middle T is mitogenic and may be required to overcome inhibition of DNA replication during the lytic life cycle of the virus.
Dilworth
S M
SM
Dept of Metabolic Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005075:Biological Evolution; D051379:Mice; D030361:Papillomavirus Infections / Q000276:immunology / Q000821:virology*; D011120:Polyomavirus / Q000276:immunology*; D011485:Protein Binding; D017978:Receptors, Growth Factor / Q000378:metabolism; D014412:Tumor Virus Infections / Q000276:immunology / Q000821:virology*; D014764:Viral Proteins / Q000378:metabolism
D000957:Antigens, Viral, Tumor; D017978:Receptors, Growth Factor; D014764:Viral Proteins