title: The topographic distribution of brain atrophy in cortical Lewy body disease: comparison with Alzheimer's disease.
abstract: The topographic distribution of brain atrophy was quantified by image analysis of fixed coronal brain slices from four patients dying with cortical Lewy body disease (CLBD) all with Alzheimer-type pathology and compared to that in four other patients of similar age and gender dying with Alzheimer's disease (AD) alone. The pattern of atrophy in CLBD (+AD) was broadly similar to that in AD alone, suggesting that tissue loss was due mostly to parallel Alzheimer-type pathological changes and that the presence of Lewy bodies in cortical and subcortical neurons contributed little, if anything, to the overall degree of atrophy.
authors.affiliation: Department of Pathological Sciences, University of Manchester, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Mann
authors.forename: J S
authors.initials: JS
authors.lastname: Snowden
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D001284:Atrophy; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology