A comparison of the accumulation of novobiocin into bacteria with its antibacterial properties.
The accumulation of novobiocin in bacteria has been compared with the MIC, inhibition of DNA biosynthesis and inhibition of the activity of isolated DNA gyrase for a range of species. There was a good correlation between MIC and the inhibition of DNA biosynthesis and DNA gyrase. Novobiocin accumulation did not correlate with any other parameter.
Barrett-Bee
K
K
Infection Research Department, Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK.
Pinder
P
P
Stawpert
J
J
D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D004264:DNA Topoisomerases, Type I / Q000187:drug effects; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009675:Novobiocin / Q000494:pharmacology*; D010539:Permeability
D004269:DNA, Bacterial; D009675:Novobiocin; D004264:DNA Topoisomerases, Type I