An adjuvant formulation based on N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with dimethyldioctadecylammonium chloride and zinc-L-proline complex as synergists.
The formulation consists of N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine, dimethyldioctadecylammonium chloride and the trace element zinc as an L-proline complex. This ternary synergistic composition shows promise as a new adjuvant.
Grubhofer
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Gerbu-Biotechnik GmbH, Gaiberg, Germany.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000737:chemistry*; D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D004140:Dinitrophenols / Q000276:immunology; D005260:Female; D005620:Freund's Adjuvant / Q000276:immunology; D006241:Haptens / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D011392:Proline / Q000276:immunology; D000644:Quaternary Ammonium Compounds / Q000276:immunology; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology; D015032:Zinc / Q000276:immunology
D000276:Adjuvants, Immunologic; D004140:Dinitrophenols; D006241:Haptens; D014677:Pharmaceutical Vehicles; D000644:Quaternary Ammonium Compounds; C034638:dinitrophenyl-bovine serum albumin; C015831:dimethyldioctadecylammonium; D012710:Serum Albumin, Bovine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C023868:N-acetyl-beta-glucosaminyl-N-acetylmuramyl-alanylisoglutamine; D005620:Freund's Adjuvant; D011392:Proline; D015032:Zinc