Regional heterogeneity of arterial structural changes.
Arterial structural changes in experimental models of hypertension and restenosis differ between vessel types and within vessels. Inspired by the diversity of short-term functional responses to vasoactive agents, hypotheses are presented with respect to the heterogeneity of structural alterations. Considered are the multifactorial nature of smooth muscle cell growth control and the possibility that vascular smooth muscle is not homogeneous but composed of different smooth muscle cell populations. These hypotheses may help explain the origin of both intervascular and intravascular heterogeneity of vascular structural responses.
Daemen
M J
MJ
Departments of Pathology, University of Limburg, Maastricht, Netherlands.
De Mey
J G
JG
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D013045:Species Specificity
D000806:Angiotensin-Converting Enzyme Inhibitors