[Role of polypeptides of pancreatic juice in the healing of intestinal anastomosis].
The possibility of using the polypeptide fraction of the pancreatic juice to accelerate healing of an intestinal anastomosis was studied in experiments. It was shown that the pancreatic polypeptides possess the properties of potential growth factors: after a single injection of these substances into the zone of the anastomosis during the operation, the synthesis of DNA and proteins in the tissues of the anastomosed intestinal segments essentially increases, which is evidence of stimulation of cell proliferation. Intensification of the proliferative processes in the tissues of the anastomosis improves the qualitative characteristics of the muscular suture-mechanical strength and biological air-tightness. The use of pancreatic polypeptides for acceleration of healing of an anastomosis formed in peritonitis showed this nontraditional method of protection of the intestinal suture to be very effective.
Antonov
A N
AN
Abakumova
O Iu
OIu
Galperin
E I
EI
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D006801:Humans; D007422:Intestines / Q000187:drug effects* / Q000473:pathology / Q000502:physiology / Q000601:surgery; D010191:Pancreatic Polypeptide / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D010191:Pancreatic Polypeptide; D004247:DNA
Rol polipeptidov pancreaticheskogo soka v zazhivlenii kishechnykh anastomozov.