[Pathological study on placenta from pregnancies with systemic lupus erythematosus].
Pathological study on the placenta of 18 cases of pregnancy complicated with systemic lupus erythematosus (SLE) and 23 cases of normal pregnancy was done. The average weight and placenta-villi area ratio of the placenta from pregnancy with SLE were significantly lower than those of the normal (P < 0.05). Scanning under electron microscope showed the placental villi of the SLE group slender and branching little, with their ends bean-sprout looking and the surface covered with pin-point holes, even slitted masses. Immunohistologic examination indicated deposition of IgG, IgA, IgM, C3 on the villi capillary wall surface, which suggested damage of the placental function of the SLE gravidae by the immunologic compounds.
Di
W
W
Ren Ji Hospital of Shanghai Second Medical University.
Hong
S Y
SY
Yan
J H
JH
D000328:Adult; D002824:Chorionic Villi / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008855:Microscopy, Electron, Scanning; D009929:Organ Size; D010920:Placenta / Q000276:immunology / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*
D007136:Immunoglobulins