title: Cross generation lead ingestion: behavioral and physiological effects in mice.
abstract: We examined some developmental and behavioral sequelae of exposing Binghamton Heterogeneous Stock (HET) mice to a 0.5% aqueous lead acetate solution (as the only available fluid source) for either none, one, two, or three generations. Lead exposure, regardless of generation, resulted in decreased body weight and a delay in age of first eye opening relative to controls, but did not delay home nest return latencies. Drinking the lead solution, across two and three successive generations, resulted in a marked and apparently cumulative decrease in pup viability, as well as an increase in dam fatality rates. However, no such cumulative or residual effects were observed on the behavioral activity of those mice who managed to survive. Perhaps a selection effect for lead-tolerant mice occurred in the present study; such an effect could account for the apparent lack of cumulative and residual behavioral effects.
authors.affiliation: Department of Psychology, State University of New York at Binghamton 13902, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Rasile
authors.forename: P W
authors.initials: PW
authors.lastname: Stewart
authors.forename: R G
authors.initials: RG
authors.lastname: Burright
authors.forename: P J
authors.initials: PJ
authors.lastname: Donovick
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007246:Infertility / Q000139:chemically induced; D007854:Lead / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051379:Mice; D016019:Survival Analysis
chemical_list: D007854:Lead