title: Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.
abstract: Ophirapstanol trisulfate [1], a new steroid trisulfate related to sokotrasterol trisulfate was isolated from a deep water marine sponge Topsentia ophiraphidites. Compound 1 exhibited significant inhibition in the guanosine diphosphate/G-protein RAS exchange assay. The structure elucidation of 1 and ophirapstanol [2] by nmr spectroscopy is described.
authors.affiliation: Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Gunasekera
authors.forename: S H
authors.initials: SH
authors.lastname: Sennett
authors.forename: M
authors.initials: M
authors.lastname: Kelly-Borges
authors.forename: R W
authors.initials: RW
authors.lastname: Bryant
mesh_terms: D000818:Animals; D002942:Circular Dichroism; D011905:Genes, ras / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification* / Q000633:toxicity; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000302:isolation & purification* / Q000633:toxicity; D013463:Sulfuric Acid Esters / Q000302:isolation & purification* / Q000633:toxicity
chemical_list: D009153:Mutagens; D013261:Sterols; D013463:Sulfuric Acid Esters; C093035:ophirapstanol trisulfate