Graminone B, a novel lignan with vasodilative activity from Imperata cylindrica.
Two novel lignans, graminones A [1] and B [2] have been isolated from Imperata cylindrica and their structures have been elucidated on the basis of their spectral data. Graminone B [2] showed inhibitory activity on the contraction of the rabbit aorta.
Matsunaga
K
K
Department of Pharmaceutical Molecular Biology, Pharmaceutical Institute, Tohoku University, Aoba, Sendai, Japan.
Shibuya
M
M
Ohizumi
Y
Y
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011817:Rabbits; D014665:Vasodilator Agents / Q000302:isolation & purification* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D005663:Furans; D014665:Vasodilator Agents; C093032:graminone B; D006139:Guaiacol