Familial disseminated atypical mycobacterial disease.
Mycobacterial disease remains a major public health problem and there appears to be a genetic component underlying susceptibility. This paper describes a group of related children who appear to have a genetic predisposition to disseminated atypical mycobacterial infection. Identification of the defect in this group could lead to better understanding of the genetics of susceptibility to mycobacterial infection.
Newport
M
M
Department of Paediatrics, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
Levin
M
M
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009165:Mycobacterium Infections, Nontuberculous / Q000235:genetics* / Q000276:immunology*; D010375:Pedigree; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma