Central cholinergic and alpha-adrenergic mediation of gastric slow wave dysrhythmias evoked during motion sickness.
Motion sickness is associated with gastric slow wave disruption. Animal models of slow wave disturbances show dependence on neural and prostaglandin pathways. Roles of these pathways in circular vection-evoked gastric dysrhythmias and nausea were tested. Eight volunteers with histories of motion sickness underwent vection (60 degrees/s), during which nausea (0 = none to 3 = severe) and electrogastrographic parameters were assessed. Tachygastric activity was expressed as the signal percentage at frequencies of > 4.5 cycles/min. Circular vection induced a maximal nausea score of 2.8 +/- 0 at 513 +/- 66 s. Tachygastric activity increased from 18 +/- 2 to 37 +/- 4% (P < 0.05) and peaked before maximal nausea. Atropine reduced nausea scores to 0 +/- 0 (P < 0.01) with no increase in tachygastric activity (14 +/- 6%). In contrast, the peripheral muscarinic antagonist methscopolamine did not reduce tachygastric activity (46 +/- 4%), nausea (1.8 +/- 0.5), or time to maximal tachygastric activity (504 +/- 80 s) with vection. Phentolamine reduced nausea (1.5 +/- 0.3, P < 0.01) and tachygastric activity, and delayed their onset, whereas propranolol and naloxone had no effect. Pretreatment with oral indomethacin (50 mg) three times daily for 3 days had no effect on vection-evoked tachygastric activity or nausea. To conclude, circular vection evokes gastric dysrhythmias that correlate temporally with maximal nausea and are suppressed by atropine, but not methscopolamine, and are reduced by phentolamine. In contrast to other models of slow wave disruption, endogenous prostaglandins play no role. Thus central cholinergic pathways mediate vection-evoked dysrhythmias with additional modulation by alpha-adrenergic pathways.
Hasler
W L
WL
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0362, USA.
Kim
M S
MS
Chey
W D
WD
Stevenson
V
V
Stein
B
B
Owyang
C
C
D000328:Adult; D001921:Brain / Q000503:physiopathology*; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000503:physiopathology*; D009325:Nausea / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D010275:Parasympathetic Nervous System / Q000503:physiopathology*; D011453:Prostaglandins / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D012016:Reference Values; D012399:Rotation; D013270:Stomach / Q000503:physiopathology*
D011453:Prostaglandins; D011942:Receptors, Adrenergic, alpha