Comparison of the vasorelaxing effect of different nitrovasodilators in conductive arterial and venous blood vessels.
We tested classically used organic nitrovasodilators such as s-nitroso-n-acetyl-D,L-penicillamine, 3-morpholino-sydnonimine, pentaerythrityl-tetranitrate, isosorbide-dinitrate, isosorbide-mononitrate, glyceryl-trinitrate on different isolated conductive arterial and venous blood vessels of the same species (rabbit). We found an up to two orders of magnitude more pronounced venoselectivety in the systemic-circulation as compared to the lung-circulation. ISMN and PETN were most venoselective nitrovasodilators, with PETN being the most potent drug in all vessels studied.
Hüsgen
B
B
Institut für Pharmakologie, Heinrich-Heine-Universität, Düsseldorf, F.R.G.
Noack
E
E
Kojda
G
G
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009574:Nitro Compounds / Q000494:pharmacology*; D011817:Rabbits; D014664:Vasodilation / Q000187:drug effects*
D009574:Nitro Compounds