title: The effect of Salinum on the symptoms of dry mouth: a pilot study.
abstract: The effect of a new saliva substitute, Salinum, was tested in 37 patients with severe symptoms of reduced salivation. The majority of the patients had suffered from hyposalivation and dry mouth for more than 8 years. The saliva substitute consisted of a water soluble extract of linseed. The physical properties of this extract are similar to those of the glycoproteins of the salivary secretions. The patients used the saliva substitute for a seven days period. Prior to the use of the extract the patients reported that the most severe symptoms of decreased salivation were a feeling of dryness in the mouth and burning sensations in the tongue, pharynx and oesophagus, The majority of the patients reported that the use of Salinum reduced the symptoms of hyposalivation. Great variation in effect occurred from patient to patient. Generally the patients with the most severe symptoms experienced the greatest relief of the symptoms when they used Salinum. Although of short duration the results of this pilot study indicate that an extract of linseeds may compensate for some aspects of the consequences of reduced salivation. Further studies are needed to elucidate the feasibility of the extract as saliva replacement.
authors.affiliation: Department of Periodontology, Centre for Oral Health Sciences, Lund University, Malmö, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Johansson
authors.forename: G
authors.initials: G
authors.lastname: Andersson
authors.forename: R
authors.initials: R
authors.lastname: Attström
authors.forename: P O
authors.initials: PO
authors.lastname: Glantz
authors.forename: K
authors.initials: K
authors.lastname: Larsson
mesh_terms: D000328:Adult; D000368:Aged; D002054:Burning Mouth Syndrome / Q000188:drug therapy / Q000209:etiology; D016371:Cranial Irradiation / Q000009:adverse effects; D003679:Deglutition; D003773:Dental Plaque / Q000209:etiology; D005260:Female; D006209:Halitosis / Q000209:etiology; D006801:Humans; D008043:Linseed Oil / Q000627:therapeutic use*; D008297:Male; D008409:Mastication; D008875:Middle Aged; D010865:Pilot Projects; D012464:Saliva, Artificial / Q000627:therapeutic use*; D012472:Salivation / Q000528:radiation effects; D013064:Speech Disorders / Q000209:etiology; D013651:Taste Disorders / Q000209:etiology; D014987:Xerostomia / Q000150:complications / Q000188:drug therapy*
chemical_list: D012464:Saliva, Artificial; D008043:Linseed Oil