title: A universal, multi-modality localization system for animal radiosurgery.
abstract: We have developed a stereotactic localization system allowing a radiosurgical approach in a number of animal models. The system utilizes fixation adapters specially designed for a particular animal, which in turn are attached to a common Brown-Roberts-Wells (BRW) compatible Delrin head ring. Each fixation adapter is constructed using materials compatible with CT, MRI, PET, and angiographic imaging studies. With such a system, radiographic localization, computerized treatment planning, and stereotactic radiation delivery can subsequently be performed in a manner identical to the procedures used for humans.
authors.affiliation: Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
authors.forename: T D
authors.initials: TD
authors.lastname: Solberg
authors.forename: A A
authors.initials: AA
authors.lastname: De Salles
authors.forename: D
authors.initials: D
authors.lastname: Hovda
authors.forename: F E
authors.initials: FE
authors.lastname: Holly
mesh_terms: D000818:Animals; D002415:Cats; D004307:Dose-Response Relationship, Radiation; D016267:External Fixators; D011829:Radiation Dosage; D016634:Radiosurgery; D051381:Rats; D013238:Stereotaxic Techniques