Gustatory parabrachial lesions disrupt taste-guided quinine responsiveness in rats.
This study examined the effects of electrophysiologically placed electrolytic lesions in the gustatory zone of the parabrachial nuclei (PBN) on the rat's taste-guided unconditioned licking of quinine hydrochloride during repeated 10-s trials. Concentration-response functions measured in water-deprived rats before and after surgery significantly shifted to the right as a result of the bilaterally placed lesions. These same rats were tested on their ability to acquire a lithium chloride (LiCl)-based conditioned taste aversion (CTA) to 0.1 M sucrose. Although the largest lesions severely affected performance in both tasks, there was only a modest correlation (r = -.447) between the extent of the lesion-induced shift in the quinine concentration-response curves and the degree of sucrose intake suppression after the first CTA conditioning trial. Thus, PBN lesions can disrupt performance on both tasks, but it appears that the neural processes governing unconditioned responsiveness to quinine may be to some extent dissociable from those subserving acquisition of a sucrose LiCl-based CTA.
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Department of Psychology, University of Florida, Gainesville 32611-2250, USA.
D000818:Animals; D001245:Association Learning / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology*; D001931:Brain Mapping; D003214:Conditioning, Classical / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D018021:Lithium Chloride / Q000633:toxicity; D008297:Male; D011149:Pons / Q000502:physiology*; D011803:Quinine; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000502:physiology*; D013652:Taste Threshold / Q000502:physiology
D011803:Quinine; D018021:Lithium Chloride