[Effect of jiutuo II injection on shock model of superior mesenteric artery occlusion in rabbit].
Tang's SMAO method was adopted to produce shock model to observe the efficacy of the Jiutuo II(JTII) intravenously given. It was found that JTII could normalize the BP rapidly, which were superior to that of Dopamine and NS groups (P < 0.05, P < 0.01). At the same time, it could decrease mortality rate, comparing with Dopamine and NS the difference was significant (P < 0.05, P < 0.01); and it could also inhibit the formation of lipid peroxides (LPO). The contents of LPO in heart, liver, kidney of shock rabbit were obviously lower than that of Dopamine and NS groups (P < 0.05, P < 0.01). The electron microscopy indicated that the drug could relieve the injury of mitochondria and lysosome in the tissues of heart, liver and kidney and protect the cellular ultrastructure of cardinal viscera. This study suggests that the JTII had good efficacy in treating the shock rabbit caused by SMAO method.
Zhou
X P
XP
Nanjing College, TCM.
Zhang
S W
SW
Jin
M W
MW
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004298:Dopamine / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D017538:Mesenteric Artery, Superior; D008641:Mesenteric Vascular Occlusion / Q000150:complications*; D011817:Rabbits; D012769:Shock / Q000188:drug therapy* / Q000209:etiology
D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D004298:Dopamine