Preparative regimens for patients with leukemias and severe aplastic anemia (overview): biological basis, experimental animal studies and clinical trials at the Fred Hutchinson Cancer Research Center.
Two purposes are served by conditioning regimens for allogeneic BMT. One is to suppress the patient's immune system so the foreign graft can take. The other purpose is to eliminate the underlying disease for which the patient is transplanted. This report reviews the recent developments in areas of conditioning programs for patients with aplastic anemia and hematological malignancies.
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Fred Hutchinson Cancer Research Center, Seattle, WA 98104-2092.
D000741:Anemia, Aplastic / Q000401:mortality / Q000628:therapy*; D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000379:methods*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004285:Dogs; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000453:epidemiology; D006801:Humans; D007165:Immunosuppression Therapy; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007938:Leukemia / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D007942:Leukemia, Experimental / Q000628:therapy; D008223:Lymphoma / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018365:Neoplasm, Residual; D011446:Prospective Studies; D016499:Radioimmunotherapy; D012074:Remission Induction; D016879:Salvage Therapy; D016019:Survival Analysis; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome; D014861:Washington / Q000453:epidemiology; D014916:Whole-Body Irradiation / Q000009:adverse effects
D000961:Antilymphocyte Serum; D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D003520:Cyclophosphamide