The inflammatory and immune response to mousepox (infectious ectromelia) virus.
The ectromelia virus (EV) has been recognized as the etiological agent of a relatively common infection in laboratory mouse colonies around the world, i.e., Europe (including Poland), USA and Asia. Due to widespread use of mice in biomedical research, it is important to study the biology of strains characteristic for a given country. This is particularly significant for the diagnosis, prevention and control ectromelia. In severe epizootics, approximately 90% morbidity is observed within colonies and mortality rate exceeding 70% is observed within 4 to 20 days from the appearance of clinical symptoms. The resistance to lethal infection is mouse strain-dependent. Several inbred strains of mice, including C57BL/6 and AKR are resistant to the lethal effects of EV infection, while others, such as A and BALB/c are susceptible. Recent studies indicate that (1) T lymphocytes, NK cells and interferon (IFN)-dependent host defenses must operate for the expression of resistance, (2) virus-specific T-cell precursors appear earlier in regional lymph nodes of resistant than susceptible mice, and (3) resistance mechanisms are expressed during early stages of infection. Over the past several years, (1) induction of anti-EV cytotoxic CD8+ T lymphocytes (CTL) responses in vivo in the absence of CD4+ (T helper) cells, (2) importance of some cytokines e.g., IFN-gamma in EV clearance at all stages of infection, and (3) induction of nitric oxide (NO) synthase, which is necessary for a substantial antiviral activity of IFN-gamma, have been demonstrated.(ABSTRACT TRUNCATED AT 250 WORDS)
Niemiałtowski
M G
MG
Department of Microbiology, Warsaw Agricultural University, Poland.
Spohr de Faundez
I
I
Gieryńska
M
M
Malicka
E
E
Toka
F N
FN
Schollenberger
A
A
Popis
A
A
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004481:Ectromelia virus / Q000276:immunology* / Q000648:ultrastructure; D004482:Ectromelia, Infectious / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular; D051379:Mice
D000914:Antibodies, Viral