Decreased bactericidal activity during the period of the postantibiotic effect.
Standard and clinical strains of Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae were subjected to continuous exposure to beta-lactams and aminoglycosides during the postantibiotic effect phase induced by rifampicin or erythromycin (for S. aureus). A significant inhibition of bactericidal activity by these agents during the PAE period was observed. The degree of inhibition was dependent both on the class of antimicrobial agent (beta-lactams > aminoglycosides) and the microorganism (Gram-negative bacilli > S. aureus).
Gudmundsson
S
S
Department of Medicine, Landspitalinn (University Hospital, Reykjavik, Iceland.
Vogelman
B
B
Craig
W A
WA
D000667:Ampicillin / Q000493:pharmacokinetics / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D018407:Bacterial Physiological Phenomena; D002435:Cefamandole / Q000493:pharmacokinetics / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000494:pharmacology*; D004917:Erythromycin / Q000493:pharmacokinetics / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009254:Nafcillin / Q000493:pharmacokinetics / Q000494:pharmacology; D012044:Regression Analysis; D012293:Rifampin / Q000493:pharmacokinetics / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors; D014031:Tobramycin / Q000493:pharmacokinetics / Q000494:pharmacology
D005839:Gentamicins; D009254:Nafcillin; D002435:Cefamandole; D004917:Erythromycin; D000667:Ampicillin; D012293:Rifampin; D014031:Tobramycin