title: A case of acute megakaryoblastic leukaemia with t(X;6)(p11.21;q23) having an X chromosome breakpoint within a 450-Kb region which is also disrupted in two classes of solid tumours.
abstract: Karyotype analysis of a case of acute megakaryoblastic leukaemia revealed an X;6 translocation as the sole abnormality. Using fluorescence in situ hybridisation on leukaemic metaphases we demonstrated that the breakpoint on the X-chromosome occurred at p11.21, within a region spanned by a YAC probe which has also been found to be disrupted in synovial sarcomas and some papillary renal cell carcinomas.
authors.affiliation: Haematology and Oncology Unit, Institute of Child Health, London, UK.
authors.forename: B R
authors.initials: BR
authors.lastname: Reeves
authors.forename: J C
authors.initials: JC
authors.lastname: Knight
authors.forename: P J
authors.initials: PJ
authors.lastname: Renwick
authors.forename: K
authors.initials: K
authors.lastname: Jani
authors.forename: H
authors.initials: H
authors.lastname: Kempski
mesh_terms: D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014960:X Chromosome