Simultaneous assessments of exocrine pancreatic function by cholesteryl-[14C]octanoate breath test and measurement of plasma p-aminobenzoic acid.
Two noninvasive tests for assessing pancreatic exocrine function, the cholesteryl-[14C]octanoate breath test and the HPLCN-benzoyl-tyrosyl-p-aminobenzoic acid/p-aminosalicylic acid (NBT-PABA/PAS) test, were simultaneously performed in nine patients with pancreatic exocrine insufficiency due to chronic pancreatitis and in nine healthy volunteers. 14CO2 output in breath and plasma PABA concentration rose slowly in patients but increased rapidly in healthy subjects. The measurement time giving the best discrimination between both groups was 120 min for the cholesteryl-[14C]octanoate breath test and 90 min for the plasma PABA test. At these points, both single-sample tests had essentially identical diagnostic sensitivity. The diagnostic sensitivities of the two single-sample tests were equal to that of the cumulative 6-h urinary PABA recovery and the cumulative 6-h urinary PABA/PAS ratio. We conclude that, for both the cholesteryl-[14C]octanoate breath test and the plasma PABA test, a single test sample is sufficient for rapid detection of impaired exocrine pancreatic function.
Bruno
M J
MJ
Department of Gastroenterology, University of Amsterdam, The Netherlands.
Hoek
F J
FJ
Delzenne
B
B
van Leeuwen
D J
DJ
Schteingart
C D
CD
Hofmann
A F
AF
Tytgat
G N
GN
D010129:4-Aminobenzoic Acid / Q000097:blood* / Q000652:urine; D000328:Adult; D000368:Aged; D010131:Aminosalicylic Acid / Q000652:urine; D001944:Breath Tests; D002250:Carbon Radioisotopes; D002788:Cholesterol Esters / Q000032:analysis*; D002908:Chronic Disease; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000503:physiopathology*; D010195:Pancreatitis / Q000175:diagnosis* / Q000503:physiopathology; D012016:Reference Values
D002250:Carbon Radioisotopes; D002788:Cholesterol Esters; C053743:cholesteryl octanoate; D010131:Aminosalicylic Acid; D010129:4-Aminobenzoic Acid