title: Incidence of late lepra reaction among multibacillary leprosy patients after MDT.
abstract: Multidrug therapy (MDT) recommended by the World Health Organization (WHO) had been administered in 1982 to a cohort of multibacillary (MB) leprosy patients. Treatment was administered for a minimum period of 2 years or until skin-smear negativity for acid-fast bacilli was achieved (whichever was later). Among 980 MB leprosy patients who completed treatment, 11 patients (1.1%) experienced lepra reactions during surveillance. Probable predictive factors are discussed. The incidence of lepra reaction seemed to be three times more common in borderline (BL) leprosy than in lepromatous (LL) leprosy. The majority of these events occurred during the first 3 years of surveillance. All of these episodes were treated with steroids without antileprosy chemotherapy. None of these patients was confirmed as experiencing a relapse during the subsequent period of surveillance.
authors.affiliation: Branch of Epidemiology and Leprosy Control, Schieffelin Leprosy Research and Training Center, Karigiri, India.
authors.forename: P
authors.initials: P
authors.lastname: Vijayakumaran
authors.forename: N
authors.initials: N
authors.lastname: Manimozhi
authors.forename: K
authors.initials: K
authors.lastname: Jesudasan
mesh_terms: D015169:Colony Count, Microbial; D004359:Drug Therapy, Combination; D006801:Humans; D015994:Incidence; D007917:Leprostatic Agents / Q000627:therapeutic use*; D015439:Leprosy, Borderline / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D015440:Leprosy, Lepromatous / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D009166:Mycobacterium leprae / Q000254:growth & development; D012008:Recurrence
chemical_list: D007917:Leprostatic Agents