Linkage between brain serotonin concentration and the sex-specific part of the Y-chromosome in mice.
The implication of the sex-specific part of the Y-chromosome (YS-SP) on brain serotonin (5-HT) level was investigated using congenic strains for this chromosomal region. The 5-HT level, which was higher in the NZB than in the CBA/H strain of mice, was depleted by the transfer of the YS-SP from NZB on CBA/H whereas the transfer of the YS-SP from CBA/H on NZB had no effect. The variations of 5-HT levels were not correlated with plasma testosterone concentration which is also dependent of the YS-SP.
Tordjman
S
S
URA CNRS 1294, Université Paris V-René Descartes, France.
Roubertoux
P L
PL
Carlier
M
M
Moutier
R
R
Anderson
G
G
Launay
M
M
Degrelle
H
H
D000818:Animals; D001923:Brain Chemistry / Q000235:genetics / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D012701:Serotonin / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity; D013739:Testosterone / Q000097:blood; D014998:Y Chromosome / Q000502:physiology*
D012701:Serotonin; D013739:Testosterone