Lymphoproliferative disease of granular lymphocytes.
We report a case of lymphoproliferative disease of granular lymphocytes that was associated with cutaneous manifestations. Marker studies of skin and blood in this patient revealed that the circulating and infiltrating cells were negative for CD3 and T-cell antigen receptor but were positive for CD16, CD56, and CD57, suggesting natural killer cell origin. The patient had a rapidly progressive course and died within 1 month of presentation.
Kugelman
L C
LC
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
Smith
B R
BR
Buckley
P
P
Katz
M E
ME
Edelson
R L
RL
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D016130:Immunophenotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000473:pathology; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology
D015703:Antigens, CD; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell