Paget's disease of the nipple and angiosarcoma of the breast following excision and radiation therapy for carcinoma of the breast.
We report a case of bilateral angiosarcomas developing in breasts after radiation therapy. The angiosarcomas developed 7 years after the first dose and 3 years after the last dose of radiation. In addition, Paget's disease of the nipple was diagnosed in the right breast. c-neu overexpression was noted in the adenocarcinoma but not in the angiosarcoma. Neither tumor was immunoreactive for c-k-ras. The oncogenic expression of the radiation-induced angiosarcoma was different from that of the radiation-resistant adenocarcinoma. The simultaneous occurrence of angiosarcoma and Paget's disease of the nipple has not been reported previously. The importance of recognizing Paget's disease in post-irradiated breasts and complications of breast conservation therapy are stressed.
Joshi
M G
MG
Department of Pathology, Deaconess Hospital, Boston, Massachusetts, USA.
Crosson
A W
AW
Tahan
S R
SR
D000230:Adenocarcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015413:Mastectomy, Simple; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D009558:Nipples / Q000473:pathology*; D010144:Paget's Disease, Mammary / Q000473:pathology*