title: [Histologic manifestations in the skin in alpha-lactoalbumin intradermal tests in patients with chronic urticaria].
abstract: Intradermal injection with alpha-lactoalbumine, 2000 PNU/ml was carried out in seven patients (1 male, 6 females, mean age 32.4 years) suffering from milk intolerance. None of the patients had a positive allergen-specific IgE antibodies in the sera (RAST). Skin test was performed on the volar part of the forearms at the same time. The area of skin reaction was estimated and measured within 36 hours on the right arm. Skin biopsy was done with a 4 mm punch after 8 hours from site of antigen injection on the left arm. Various cells infiltrating the site of antigen instillation were present. Leukocytoclastic vasculitis was only found in patients with dual intradermal reaction (immediate and late onset of response; 8 12 hours). These results indicate that local skin reaction to alpha-lactoal-bumine is mediated by diverse immune mechanisms, and that it may be of clinical significance for the diagnosis of cow milk allergy in adults.
authors.affiliation: Department of Allergy and Clinical Immunology, Zvezdara University Hospital, Belgrade.
authors.forename: S
authors.initials: S
authors.lastname: Paranos
authors.forename: S
authors.initials: S
authors.lastname: Bojović
authors.forename: V
authors.initials: V
authors.lastname: Miletić
authors.forename: N
authors.initials: N
authors.lastname: Despotović
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007428:Intradermal Tests; D007768:Lactalbumin / Q000009:adverse effects*; D008297:Male; D016269:Milk Hypersensitivity / Q000175:diagnosis*; D012867:Skin / Q000473:pathology*; D014581:Urticaria / Q000209:etiology*
chemical_list: D007768:Lactalbumin
vernacular_title: Histoloske pojave u kozi u toku intradermnog testa alfa-laktoalbuminom kod bolesnika s hronicnom urtikarijom.