title: Emergence of karyotypically unrelated clone in remission of de novo acute myeloblastic leukaemias.
abstract: Serial cytogenetic analysis revealed karyotypically unrelated clones in four patients with acute myeloblastic leukaemia (AML) in remission. At diagnosis, three patients had t(8;21)(q22;q22) and one had an inv(16)(p13q22). After 18-22 months in remission, different clones emerged in each patient with myelodysplastic features of the bone marrow cells. The emergence of clones with abnormalities of chromosome 7 in remission seems to be an unfavourable factor for prognosis.
authors.affiliation: Department of Cancer Cytogenetics, Hiroshima University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kudoh
authors.forename: H
authors.initials: H
authors.lastname: Asou
authors.forename: T
authors.initials: T
authors.lastname: Kyo
authors.forename: H
authors.initials: H
authors.lastname: Asaoku
authors.forename: H
authors.initials: H
authors.lastname: Dohy
authors.forename: M
authors.initials: M
authors.lastname: Eguchi
authors.forename: S
authors.initials: S
authors.lastname: Tashiro
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: N
authors.initials: N
authors.lastname: Kamada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001483:Base Sequence; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D014411:Neoplastic Stem Cells / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012074:Remission Induction