[Pathogenesis and diagnosis of polycystic ovary syndrome].
OBJECTIVE
Growth factors (human growth hormone, HGH; insulin-like growth factor I, IGF-I) and insulin were evaluated concerning their pathogenetic significance in patients with polycystic ovary syndrome (PCOS).


METHODS
Twenty-eight women with signs of PCOS were examined; 24 women without signs of PCOS served as controls.


RESULTS
Women with PCOS showed significantly increased androgen, IGF-I, insulin and glucose levels, higher glucose concentrations in the oral glucose tolerance test and a higher body mass index. The concentration of HGH, the HGH/IGF-I ratio and the number of insulin receptors on red blood cells were significantly decreased in women with PCOS. The insulin receptor affinity, the maximum binding and the insulin-receptor complex were increased in PCOS patients.


CONCLUSIONS
A decreased number of insulin receptors, a disturbed insulin receptor binding, the resulting hyperinsulinemia as well as high levels of IGF-I are to be considered as important factors in the pathogenesis of PCOS.
Urdl
W
W
Klinische Abteilung für gynäkologische, Universitätsklinik Graz, Osterreich.
Desoye
G
G
D000293:Adolescent; D000328:Adult; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D011972:Receptor, Insulin / Q000502:physiology
D006728:Hormones; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D011972:Receptor, Insulin
Pathogenese und Diagnostik des polyzystischen Ovarsyndroms.