How unique are pathogenic anti-DNA autoantibody V regions?
Unique characteristics of the molecular structure of V regions encoding pathogenic anti-DNA autoantibodies have become apparent upon comparison of a large number of nucleotide sequences encoding this autospecificity. Moreover, the generation of transgenic animals expressing V regions encoding anti-DNA autoantibodies has shed light on the tolerizing mechanisms that regulate B cells producing antibodies against DNA.
Logtenberg
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Department of Immunology, University Hospital Utrecht, Medical School, The Netherlands.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000918:Antibody Specificity; D001324:Autoantigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D004247:DNA / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D007135:Immunoglobulin Variable Region; D004247:DNA