title: [Effect of a diet supplemented with soybean oil or fish oil on the reversibility of docosahexaenoic acid deficiency (22:6w3) in the brain and erythrocytes of rats].
abstract: This study was undertaken, to evaluate the effects of dietary supplements containing either soybean oil (19:3w3; ALA), or fish oil (22:6w3; DHA), added to the lactating rat dam diet, on the levels of DHA in brain and erythrocytes of DHA deficient pups. Pregnant rats fed omega 3 deficient diets were divided at parturition into three groups. One group was kept on the same diet fed during pregnancy. The two remaining groups received the above mentioned omega 3 supplements. These feeding regimens were maintained during 18 days. Supplementation of diet with 114 mg DHA/100g diet, increased significantly the concentration of DHA in brain and erythrocytes of the suckling rats. In contrast, the effects of the supplementation with ALA (700 mg/100g diet), were limited to the increase of DHA content in the brain. This increase however, was partial, reaching only 50% of the normal. Results suggest that newborn rat has a limited capacity to convert DHA from ALA, becoming dependent of preformed DHA supply to cover DHA requirements at the cellular level.
authors.affiliation: Dpto. de Nutrición, Facultad de Medicina, Universidad de Chile.
authors.forename: J
authors.initials: J
authors.lastname: Araya
authors.forename: P
authors.initials: P
authors.lastname: Robert
authors.forename: C
authors.initials: C
authors.lastname: Barriga
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001923:Brain Chemistry; D004032:Diet; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D004912:Erythrocytes / Q000737:chemistry*; D005227:Fatty Acids / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D005527:Food, Fortified; D008055:Lipids / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D011247:Pregnancy; D051381:Rats; D013024:Soybean Oil / Q000008:administration & dosage*
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008055:Lipids; D010743:Phospholipids; D004281:Docosahexaenoic Acids; D013024:Soybean Oil
vernacular_title: Efecto de la suplementación dietética con aceite de soya o marino en la reversibilidad de la deficiencia de ácido docosahexaenoico (22:6w3) en el cerebro y eritrocitos de ratas.