title: Human diets cooked by microwave or conventionally: comparative sub-chronic (13-wk) toxicity study in rats.
abstract: To compare the possible effects of microwave and conventional cooking on a range of common dietary components, mixed human diets containing beef, potatoes and vegetables were fed to groups of 10 male and 10 female Wistar rats for 13 wk. The diet ingredients were cooked by either of the methods in a normal and an abused manner, the latter consisting of the normal treatment followed by two cycles of reheating to approximately 85 degrees C and cooling. The cooked ingredients were freeze-dried, ground and mixed with supplements of vitamins and minerals to meet the rat requirements. An additional control group was fed a cereal-based rodent diet. Criteria to assess toxicity included clinical observations, ophthalmoscopy, growth, food and water intake, haematology, clinical chemistry, urinalysis, organ weights, micronucleated erythrocytes in bone marrow, gross examination at autopsy and microscopic examination of a wide range of organs. The results indicate no adverse effects of the diets cooked by microwave compared with those cooked conventionally.
authors.affiliation: TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Jonker
authors.forename: H P
authors.initials: HP
authors.lastname: Til
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001773:Blood Cells / Q000473:pathology; D001774:Blood Chemical Analysis; D001854:Bone Marrow Cells; D004326:Drinking; D004435:Eating; D004912:Erythrocytes / Q000166:cytology; D005260:Female; D005502:Food / Q000528:radiation effects / Q000633:toxicity*; D005511:Food Handling; D005612:Freeze Drying; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D008872:Microwaves / Q000009:adverse effects*; D009929:Organ Size / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013047:Specific Pathogen-Free Organisms; D016482:Urinalysis; D001743:Urinary Bladder / Q000473:pathology