[Role of non-protein factor of splenin in the regulation of antibody formation].
Non-protein factor of splenin that possesses T-mitogen activity under experimental conditions reproduces immunomodulatory action of the native drug in what concerns regulation of immunoglobulin synthesis. Premedication of CBA mice with the isolated factor increases primary immune response to ram erythrocytes by 64%. When immediate allergic reaction develops in Wistar rats and BALB/c mice this factor suppresses IgE-antibody production via stimulation of suppressors T-cells.
Oliĭnyk
B V
BV
Bogdanovych
L V
LV
Zhuravskyĭ
M H
MH
D000818:Animals; D000831:Animals, Newborn; D007073:Immunoglobulin E / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D007074:Immunoglobulin G / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008222:Lymphokines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D013946:Thymopoietins / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D007074:Immunoglobulin G; D008222:Lymphokines; D013946:Thymopoietins; D007073:Immunoglobulin E; C032841:thymopoietin III
Rol nebilkovoho chynnyka spleninu v rehuliatsiĭ antytilohenezu.