title: Diagnostic value of detecting JC virus DNA in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.
abstract: JC virus DNA was detected by PCR in the cerebrospinal fluid of 17 of 23 (73.9%) patients with confirmed cases of progressive multifocal leukoencephalopathy and 2 of 48 (4.2%) controls without progressive multifocal leukoencephalopathy. The sensitivity and specificity of this PCR were 74 and 95.8%, respectively, while the positive and negative predictive values were 89.5 and 88.5%, respectively.
authors.affiliation: Department of Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada.
authors.forename: I W
authors.initials: IW
authors.lastname: Fong
authors.forename: C B
authors.initials: CB
authors.lastname: Britton
authors.forename: K E
authors.initials: KE
authors.lastname: Luinstra
authors.forename: E
authors.initials: E
authors.lastname: Toma
authors.forename: J B
authors.initials: JB
authors.lastname: Mahony
mesh_terms: D004279:DNA, Viral / Q000134:cerebrospinal fluid* / Q000235:genetics; D005069:Evaluation Studies as Topic; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D007577:JC Virus / Q000235:genetics / Q000302:isolation & purification*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods* / Q000706:statistics & numerical data; D012680:Sensitivity and Specificity
chemical_list: D004279:DNA, Viral