title: The comparative inhibitory and bactericidal activities of meropenem and imipenem against Acinetobacter spp. and Enterobacteriaceae resistant to second generation cephalosporins.
abstract: The inhibitory and bactericidal activities of meropenem and imipenem were compared using Acinetobacter spp. and Enterobacteriaceae resistant to second generation cephalosporins. The inhibitory activity of both agents was similar for Acinetobacter spp. but meropenem was more active against the Enterobacteriaceae. Bactericidal activities were compared employing time-kill curves which indicated meropenem was more bactericidal than imipenem against Enterobacteriaceae at pharmacologically achievable concentrations while imipenem was more bactericidal than meropenem against Acinetobacter spp.
authors.affiliation: Department of Medical Microbiology, Southmead Health Services NHS Trust, Westbury-on Trym, Bristol, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: MacGowan
authors.forename: K E
authors.initials: KE
authors.lastname: Bowker
authors.forename: K A
authors.initials: KA
authors.lastname: Bedford
authors.forename: H A
authors.initials: HA
authors.lastname: Holt
authors.forename: D S
authors.initials: DS
authors.lastname: Reeves
authors.forename: A
authors.initials: A
authors.lastname: Hedges
mesh_terms: D000150:Acinetobacter / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D002444:Cefuroxime / Q000494:pharmacology*; D018550:Cephalosporin Resistance; D004755:Enterobacteriaceae / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D015378:Imipenem / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem; D002444:Cefuroxime