Engineering bispecific antibodies.
Bispecific antibodies have immense potential as reagents and in medicine. Until recently, they were made by combining monoclonal antibodies of two different specificities in vitro, or by fusion of the corresponding hybridomas. Protein engineering now offers the chance to construct a range of small 'designer' bispecific antibodies using antibody fragments as building blocks.
Holliger
P
P
MRC Centre for Protein Engineering, Cambridge, UK.
Winter
G
G
D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000302:isolation & purification*; D001709:Biotechnology; D015195:Drug Design; D015202:Protein Engineering
D000906:Antibodies