Cannabiorci- and 8-chlorocannabiorcichromenic acid as fungal antagonists from Cylindrocarpon olidum.
Cannabiorcichromenic acid and 8-chlorocannabiorcichromenic acid [8-chloro-5-hydroxy-2,7-dimethyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran -6- carboxylic acid] were identified as active components in cultures of Cylindrocarpon olidum which antagonized various other fungi. Experiments performed with the purified acids confirmed the antifungal activity; in addition, they revealed that the acids had antibiotic properties towards gram-positive bacteria and were toxic to nematodes.
Quaghebeur
K
K
Faculty of Agricultural and Applied Biological Sciences, K. U. Leuven, Belgium.
Coosemans
J
J
Toppet
S
S
Compernolle
F
F
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry*; D009348:Nematoda / Q000382:microbiology
C090973:8-chlorocannabiorcichromenic acid; D000935:Antifungal Agents; D001578:Benzopyrans; C090972:cannabiorcichromenic acid