Considerations about the prophylactic role of T cell vaccination in HIV infection.
The AIDS epidemic in Romania has properties that are both common to countries of Eastern Europe and unique to Romania. The unique aspects include the large number of cases in children infected parenterally and a relatively low but steadily increasing number of HIV infected adults. Other groups of children and adults were also exposed at risk to acquire HIV by transfusion with unscreened blood or by multiple parenteral treatments with potentially contaminated needles. Our hypothesis was that a substantial number of people in area of high endemicity was "silently" infected but did not undergo specific immune response or clinical signs. In an attempt to explore the possibility that immunization with autologous proteins (consequence of multiple transfusions) can play a role in the protection from HIV infection or in slowing down the progression of disease, we compared the incidence of autoantibodies (anti-nuclear, smooth muscle and anti-HEp-2) in a group of long survivors children with AIDS, in HIV infected children with rapid evolution and in adults at risk for parenteral acquisition of blood borne viral disease. We analyzed also the incidence of some blood borne viral infections and the presence of anti-HLA antibodies in the same groups of patients. Our results do not support the suggestion that HIV infection or AIDS can be prevented, respectively, delayed by T-cell vaccination.
Ruţă
S M
SM
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Alexandrescu
R
R
Antipa
C
C
Tirdei
G
G
Popescu
A
A
Cernescu
C
C
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D016219:Immunotherapy, Adoptive; D008297:Male; D013601:T-Lymphocytes; D014611:Vaccination / Q000379:methods*