Inhibitory peptides in hematopoiesis.
This paper will review the present knowledge on two small chemically unrelated peptides, the pentapeptide pGlu-Glu-Asp-Cys-Lys (pEEDCK) and the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (AcSDKP, Seraspenide) focusing on 1) their inhibitory effects on normal hematopoiesis, 2) their effect on malignant cells, especially leukemic cells, and 3) their potential clinical use as marrow protectors during cancer therapy.
Guigon
M
M
Department of Hematology, CHU Saint Antoine, Paris, France.
Bonnet
D
D
D000818:Animals; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D009842:Oligopeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives
D009842:Oligopeptides; C040758:hemoregulatory peptide 5b; C058504:goralatide; D011761:Pyrrolidonecarboxylic Acid