title: Vagal modulation of the insulin secretory response to KCl loading in nephrectomized dogs.
abstract: In K-loaded intact and nephrectomized control dogs there is a four-to five-fold increase of basal serum insulin. With beta receptor blockade in K-loaded intact animals the increase of basal serum insulin is less than 1/4 to that in controls; in those with nephrectomy, the increase is similar to that in controls. Cervical vagotomy in K-loaded intact dogs does not alter (influence) the increase of serum insulin; in those with nephrectomy there is a striking increase. In K-loaded intact dogs cervical vagotomy added to beta receptor blockade has no influence i.e., the response is the same as that to blockade alone; in those with nephrectomy, the increase produced by vagotomy is suppressed. Results suggest that in controls with nephrectomy, the insulin secretory response does not involve beta receptors of pancreatic islet B cells owing to restraint by efferent impulses in the cervical vagi. Interruption of the impulse by vagotomy releases the restraint, with resulting hyperactivity; the accompanying hyperinsulinemia may be the result of suppression of the hyperactive receptors by beta receptor blockade.
authors.affiliation: Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: N
authors.initials: N
authors.lastname: Hiatt
authors.forename: J R
authors.initials: JR
authors.lastname: Hiatt
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose; D004285:Dogs; D004525:Efferent Pathways; D005260:Female; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000294:innervation; D007668:Kidney / Q000502:physiology*; D008297:Male; D009392:Nephrectomy; D011189:Potassium Chloride / Q000494:pharmacology*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D007328:Insulin; D011189:Potassium Chloride