Lack of influence of non-inherited maternal HLA-DR alleles on susceptibility to rheumatoid arthritis.
OBJECTIVE
To reproduce findings from previous reports that non-inherited maternal HLA class II antigens might contribute to rheumatoid arthritis (RA) susceptibility in the offspring.


METHODS
Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods.


RESULTS
There was no evidence of an increase in either non-inherited maternal HLA-DR4 or the HLA-DRB1 shared epitope as a whole compared with the frequency expected using the non-inherited paternal antigens as controls.


CONCLUSIONS
The numbers of probands who were shared epitope negative were small, but we are unable to confirm in these families the findings that non-inherited maternal HLA contributes an additional susceptibility factor to rheumatoid arthritis.
Silman
A J
AJ
ARC Epidemiology Research Unit, University of Manchester, United Kingdom.
Hay
E M
EM
Worthington
J
J
Thomson
W
W
Pepper
L
L
Davidson
J
J
Dyer
P A
PA
Ollier
W E
WE
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D015804:HLA-DR4 Antigen / Q000032:analysis; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D009035:Mothers
D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D059811:HLA-DRB1 Chains