Antioxidant therapy using high dose vitamin C: reduction of postburn resuscitation fluid volume requirements.
Twenty-four guinea pigs with third degree burns over 70% of the body surface area were divided equally into four groups. At 0.5 hours postburn, all groups received Ringer's lactate solution (R/L) according to the Parkland formula. The infusion rate was then reduced to 25% of the Parkland formula at 1.5 hours postburn. Group 1 received only R/L, and groups 2, 3 and 4 received adjuvant vitamin C (14.2 mg/kg/hr) until 4, 8, and 24 hours postburn, respectively. The volume of R/L was reduced by that of vitamin C solution so that the hourly sodium and fluid intake in each group was the same. Groups 1 and 2 demonstrated higher hematocrit and lower cardiac output values than did group 3, suggesting hypovolemia and hemoconcentration in these groups. Group 3 showed hematocrit and cardiac output values equivalent to those in group 4. We conclude that high dose vitamin C infusion maintains hemodynamic stability in the presence of a reduced resuscitation fluid volume provided vitamin C is administered for a minimum of 8 hours postburn.
Matsuda
T
T
Department of Surgery, Cook County Hospital, University of Illinois, Chicago 60612, USA.
Tanaka
H
H
Reyes
H M
HM
Richter
H M
HM
Hanumadass
M M
MM
Shimazaki
S
S
Matsuda
H
H
Nyhus
L M
LM
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D002056:Burns / Q000503:physiopathology / Q000628:therapy*; D002199:Capillary Permeability / Q000502:physiology; D005260:Female; D005440:Fluid Therapy; D006168:Guinea Pigs; D008297:Male; D012151:Resuscitation
D000975:Antioxidants; D001205:Ascorbic Acid