[The role of lipid peroxidation in the pathogenesis of neuropathological syndromes and in experimental therapy].
Activated lipid peroxidation observed in brain homogenates in experimental choreoid hyperkinesis and bemegride epilepsy can be arrested by antioxidant pretreatment. The same is true for parkinsonian and "malignant locomotion" syndromes provoked by intrastriatal pro-oxidant (oxidized oleinic acid) microinjection and systemic administration of haloperidol. Experimental therapy of choreoid hyperkinesis with GABA-positive and dopamine-blocking drugs alone proved ineffective. The effect was achieved at combined application of antioxidant and GABA-positive drugs.
Aliev
M N
MN
Rzaev
R N
RN
Mamedbeĭli
T N
TN
Aliev
A N
AN
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001534:Bemegride; D001923:Brain Chemistry / Q000187:drug effects; D002819:Chorea / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D018755:GABA Agonists / Q000627:therapeutic use; D006220:Haloperidol; D006948:Hyperkinesis / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D010852:Picrotoxin; D051381:Rats; D013577:Syndrome
D000975:Antioxidants; D001534:Bemegride; D018755:GABA Agonists; D006220:Haloperidol; D010852:Picrotoxin
Rol' perekisnogo okisleniia lipidov v patogeneze nekotorykh neĭropatologicheskikh sindromov i pri éksperimental'noĭ terapii.