title: Gas chromatographic/mass spectrometric analyses of unknown analytical response in imported Fava beans: 4-chloro-6-methoxyindole.
abstract: A halogenated unidentified analytical response (UAR) was encountered in a number of imported Fava bean samples during the Food and Drug Administration's routine pesticide-monitoring program. Gas chromatographic/mass spectrometric (GC/MS) analyses identified the halogenated component as 4-chloro-6-methoxyindole, a naturally occurring promutagen in Fava beans that has been linked to incidents of gastric cancer. Data from electron impact, positive and negative chemical ionization, collision-induced dissociation, and deuteration studies of this compound are presented, along with GC retention time data.
authors.affiliation: U.S. Food and Drug Administration, Northeast Regional Laboratory, Brooklyn, NY 11232, USA.
authors.forename: G
authors.initials: G
authors.lastname: Petzinger
authors.forename: T L
authors.initials: TL
authors.lastname: Barry
authors.forename: J A
authors.initials: JA
authors.lastname: Roach
authors.forename: S M
authors.initials: SM
authors.lastname: Musser
authors.forename: J
authors.initials: J
authors.lastname: Sphon
mesh_terms: D007887:Fabaceae / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification*; D008970:Molecular Weight; D010946:Plants, Medicinal
chemical_list: D007211:Indoles; C043300:4-chloro-6-methoxyindole