Plasma amino acid imbalance in patients with lung and breast cancer.
In order to evaluate whether different solid tumors may specifically influence plasma free amino acid (PFAA) profile, PFAA were analysed in seventy-four patients with lung (41 patients) and breast cancer (33 patients) and 28 healthy subjects. In lung cancer patients a significant reduction of gluconeogenic amino acids, threonine, serine, glycine and a significant increase of free tryptophan and glutamic acid was found. In breast cancer patients a significant increase of ornithine, glutamic acid and free tryptophan was found. The comparison of PFAA profiles between lung and breast cancer suggests that different tumors have a different influence on the host's PFAA pattern.
Cascino
A
A
III Dept. of Internal Medicine, University La Sapienza, Rome, Italy.
Muscaritoli
M
M
Cangiano
C
C
Conversano
L
L
Laviano
A
A
Ariemma
S
S
Meguid
M M
MM
Rossi Fanelli
F
F
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood*; D005260:Female; D005943:Gluconeogenesis; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism
D000596:Amino Acids; D009124:Muscle Proteins; D009363:Neoplasm Proteins