title: The retinoblastoma tumor suppressor protein.
abstract: Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/effectors of pRb have been identified recently, and the system of kinases that inactivate pRb is proving to be complex.
authors.affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Hinds
mesh_terms: D000818:Animals; D017353:Gene Deletion; D016161:Genes, Retinoblastoma; D006801:Humans; D016160:Retinoblastoma Protein / Q000235:genetics / Q000502:physiology*
chemical_list: D016160:Retinoblastoma Protein