Glycine metabolism in anaerobes.
Some strict anaerobic bacteria catalyze with glycine as substrate an internal Stickland reaction by which glycine serves as electron donor being oxidized by glycine-cleavage system or as electron acceptor being reduced by glycine reductase. In both cases, energy is conserved by substrate level phosphorylation. Except for the different substrate-activating proteins PB, reduction of sarcosine or betaine to acetyl phosphate involves in Eubacterium acidaminophilum the same set of proteins as observed for glycine, e.g. a unique thioredoxin system as electron donor and an acetyl phosphate-forming protein PC interacting with the intermediarily formed Secarboxymethylselenoether bound to protein PA.
Andreesen
J R
JR
Institute of Microbiology, University of Halle, Germany.
D000594:Amino Acid Oxidoreductases / Q000235:genetics / Q000378:metabolism; D000693:Anaerobiosis; D001421:Bacteria, Anaerobic / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D003013:Clostridium / Q000378:metabolism; D005051:Eubacterium / Q000378:metabolism; D005998:Glycine / Q000378:metabolism*; D050841:Glycine Dehydrogenase (Decarboxylating); D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051140:Selenoproteins; D013879:Thioredoxins / Q000378:metabolism; D014166:Transferases / Q000235:genetics / Q000378:metabolism
D002352:Carrier Proteins; D009097:Multienzyme Complexes; D011506:Proteins; D051140:Selenoproteins; C064525:glycine cleavage system; D013879:Thioredoxins; D010088:Oxidoreductases; D000594:Amino Acid Oxidoreductases; D050841:Glycine Dehydrogenase (Decarboxylating); D014166:Transferases; D005998:Glycine