title: Extrapontine myelinolysis after correction of chronic hyponatraemia with isotonic saline.
abstract: Rapid correction of severe chronic hyponatraemia with hypertonic saline can cause central pontine myelinolysis. Less well appreciated are the dangers of rapid correction with isotonic saline. A case is reported in which correction of severe hyponatraemia by 11 mmol/l in 24 hours with isotonic saline produced extensive extrapontine myelinolysis, one of the manifestations of the osmotic demyelination syndrome.
authors.affiliation: Oxford University, Radcliffe Infirmary, Oxford.
authors.forename: S J
authors.initials: SJ
authors.lastname: Ellis
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy*; D007552:Isotonic Solutions; D008279:Magnetic Resonance Imaging; D012965:Sodium Chloride / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007552:Isotonic Solutions; D012965:Sodium Chloride