Mitochondrial alteration caused by cnidarian toxins: a preliminary study.
Cnidarians contain different toxins causing cytotoxic and cytolytic effects probably due to cell membrane alterations. Mitochondria were used here as an experimental model system to characterize the action of cnidarian toxins. Toxin from the sea anemone Anemonia sulcata affects the function of rat liver mitochondria. Effects are dose- and time-dependent and they disappear when Ca2+ is absent. This toxin could therefore have a phospholipase-like action, as reported for other cnidarians. Mitochondrial alterations by cnidarian toxins could therefore be a particular case of a general mechanism of toxicity directed towards biological membranes.
Arillo
A
A
Istituto di Zoologia, Università di Genova.
Burlando
B
B
Carli
A M
AM
Mariottini
G L
GL
D000818:Animals; D002118:Calcium / Q000502:physiology*; D003064:Cnidarian Venoms / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000378:metabolism; D007425:Intracellular Membranes / Q000187:drug effects; D008293:Malates / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000648:ultrastructure; D008954:Models, Biological; D010101:Oxygen Consumption / Q000187:drug effects; D010740:Phospholipases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012615:Sea Anemones / Q000502:physiology; D013997:Time Factors
D003064:Cnidarian Venoms; D008293:Malates; C055387:toxin IV (Anemonia sulcata); D018698:Glutamic Acid; C036310:toxin I (Anemonia sulcata); C028800:toxin II (Anemonia sulcata); C032104:toxin III (Anemonia sulcata); C030298:malic acid; D010740:Phospholipases; D002118:Calcium