Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication.
Interleukin-1 beta (IL-1 beta), a cytokine released by activated immune cells, elicits various illness symptoms including hyperthermia. Previous hypotheses to account for these actions have focused on blood-borne IL-1 beta exerting its effects directly at the level of the brain. However, recent behavioral and physiological evidence suggest that IL-1 beta can activate the subdiaphragmatic vagus. The present experiments demonstrate that subdiaphragmatic vagal transection disrupts the hyperthermia-inducing effects of recombinant human IL-1 beta and stress. These data provide evidence for a novel route of immune-brain communication, as well as a novel route whereby stress can influence physiological processes.
Watkins
L R
LR
Department of Psychology, University of Colorado at Boulder 80309, USA.
Goehler
L E
LE
Relton
J K
JK
Tartaglia
N
N
Silbert
L
L
Martin
D
D
Maier
S F
SF
D000818:Animals; D001921:Brain / Q000276:immunology*; D005334:Fever; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological; D013997:Time Factors; D014628:Vagotomy
D007375:Interleukin-1