title: Management of impotence due to spinal cord injury using low dose papaverine.
abstract: Erectile dysfunction is a common complication of spinal cord injury. Of the 68 spinal cord injured men in whom treatment with papaverine was initiated a therapeutic dosage was determined in 50 (74%). Papaverine was injected into the base of one corpora cavernosum. The dose started at 3 mg and was increased at weekly or longer intervals until an effective dose was determined. There were 15 (30%) men with tetraplegia and 35 (70%) men with paraplegia. The dosage of papaverine did not relate to the level or extent of injury. Doses of 12 mg or less were used in 56% of patients. Low dose papaverine is a safe and effective means of restoring erections in spinal cord injured men.
authors.affiliation: Schwab Rehabilitation Hospital, Chicago, IL 60608, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Yarkony
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Palmer
authors.forename: E J
authors.initials: EJ
authors.lastname: Roth
authors.forename: S
authors.initials: S
authors.lastname: Rayner
authors.forename: L
authors.initials: L
authors.lastname: Lovell
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D007172:Erectile Dysfunction / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010208:Papaverine / Q000627:therapeutic use*; D012725:Sexual Behavior; D013119:Spinal Cord Injuries
chemical_list: D010208:Papaverine