title: [The effect of the complement system on the acute reversible rejection of kidney transplants].
abstract: Although the involvement of complement in hyperacute renal allograft rejection is well established, its possible implication in acute reversible and chronic graft rejection remains uncertain. In recent clinical studies with a total of 83 patients undergoing renal transplantation, plasma levels of complement activation products were elevated 4-7 days before clinical diagnosis of graft rejection. Immunohistochemical analysis of biopsies revealed local complement activation with glomerular deposition of the terminal C5b-9 complex within 1 h after organ reperfusion. Increasing levels of complement activation products, preceding the clinical manifestation of renal graft rejections may be of diagnostic value in recognizing patients at risk.
authors.affiliation: Institut für Immunologie, Universität Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Kirschfink
authors.forename: T
authors.initials: T
authors.lastname: Wienert
authors.forename: E B
authors.initials: EB
authors.lastname: A Prado
authors.forename: S
authors.initials: S
authors.lastname: Pomer
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003174:Complement C1 Inactivator Proteins / Q000378:metabolism; D015926:Complement C3a / Q000378:metabolism; D003165:Complement System Proteins / Q000276:immunology*; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D003174:Complement C1 Inactivator Proteins; D015926:Complement C3a; D003165:Complement System Proteins
vernacular_title: Zur Bedeutung des Komplementsystems für die akute reversible Abstossungsreaktion von Nierentransplantaten.