Linkage analysis of 26 Canadian breast and breast-ovarian cancer families.
We have examined 26 Canadian families with hereditary breast or ovarian cancer for linkage to markers flanking the BRCA1 gene on chromosome 17q12-q21. Of the 15 families that contain cases of ovarian cancer, 94% were estimated to be linked to BRCA1. In contrast, there was no overall evidence of linkage in the group of 10 families with breast cancer without ovarian cancer. A genetic recombinant in a breast-ovarian cancer family indicates a placement of BRCA1 telomeric to D17S776, and helps to define the region of assignment of the cancer susceptibility gene. Other cancers of interest that appeared in the BRCA1-linked families included primary peritoneal cancer, cancer of the fallopian tube, and malignant melanoma.
Tonin
P
P
Department of Medicine, McGill University, Montreal, Quebec, Canada.
Moslehi
R
R
Green
R
R
Rosen
B
B
Cole
D
D
Boyd
N
N
Cutler
C
C
Margolese
R
R
Carter
R
R
McGillivray
B
B
D000328:Adult; D019313:BRCA1 Protein; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics*; D002170:Canada; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008545:Melanoma / Q000235:genetics; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D014157:Transcription Factors / Q000235:genetics*
D019313:BRCA1 Protein; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D014157:Transcription Factors