Structure, function and application of the coiled-coil protein folding motif.
Recent X-ray analyses and synthetic model studies of the coiled-coil motif have clarified roles for hydrophobic core residues and ionic interactions in determining stability, selectivity, stoichiometry and orientation of alpha-helices in this structure. Although much remains to be learnt, current knowledge now enables this motif to be used in novel constructs and points the way to a more explicit understanding of native coiled-coil formation and protein folding in general.
Adamson
J G
JG
Protein Engineering Network of Centres of Excellence, University of Alberta, Edmonton, Canada.
Zhou
N E
NE
Hodges
R S
RS
D000595:Amino Acid Sequence; D001709:Biotechnology; D008969:Molecular Sequence Data; D015394:Molecular Structure; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry
D011506:Proteins