Histological evidence for neuroprotective action of nebracetam on ischemic neuronal injury in the hippocampus of stroke-prone spontaneously hypertensive rats.
The protective effect of nebracetam on ischemic neuronal damage was histologically examined in the pyramidal cell layer of the hippocampal CA1 subfield 7 days after operation using stroke-prone spontaneously hypertensive rats (SHRSP) subjected to 10-min bilateral carotid occlusion. Nebracetam (50 and 100 mg/kg), given orally 10 min after reperfusion, dose-dependently protected against ischemic delayed neuronal damage in the SHRSP with occlusion; however, the blood pressure remained unchanged following nebracetam administration. These findings further support the notion that nebracetam protects against ischemic delayed neuronal cell death in the hippocampus.
Nakashima
M N
MN
Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
Kataoka
Y
Y
Yamashita
K
K
Kohzuma
M
M
Ichikawa
M
M
Niwa
M
M
Kohno
Y
Y
Taniyama
K
K
D000818:Animals; D002545:Brain Ischemia; D002452:Cell Count / Q000187:drug effects; D006624:Hippocampus; D006973:Hypertension; D008297:Male; D018696:Neuroprotective Agents; D010277:Parasympathomimetics / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000166:cytology; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
D018696:Neuroprotective Agents; D010277:Parasympathomimetics; D011760:Pyrrolidinones; C056640:nebracetam