[Effect of anti-fibronectin-serum on fertilization capacity of human spermatozoa].
Using the in vitro penetration test, we initially studied effects of anti-fibronectin (FN)-serum on fertilization capacity of human spermatozoa. Owing to the coincubation of anti-FN-serum in a heterologous system (human spermatozoa and zona-free gold hamster oocyte), a certain increase was found in the penetration rate at a low concentration of anti-FN-serum. The penetration rate in the treated group was 20% higher than that in the control group at an anti-FN-serum concentration of 10 microliters/ml (P < 0.05), but at a higher concentration of anti-FN-serum, the penetration rate was not affected. The results suggest that anti-FN-serum can improve the fertilization capacity of human spermatozoa, help to treat the unexplained infertility, and increase the repregnancy rate of vasovasotomy.
Xu
F
F
Sichuan Family Planning Research Institute.
Cui
X
X
Yang
F
F
D000818:Animals; D006224:Cricetinae; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005353:Fibronectins / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D013084:Sperm-Ovum Interactions / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology
D005353:Fibronectins; D007106:Immune Sera