Age-related changes in androgen receptor levels in cranial nerve nuclei of male rats.
Sensory and motor events are important for mating, and several cranial nerve nuclei mediating these events contain androgen receptors (AR). Since mating behavior declines with age, we tested whether AR binding is decreased in cranial nerve nuclei of old male rats. Cytosol and cell nuclear androgen receptor (AR) binding was assessed in the cochlear, hypoglossal and facial nuclei in young (4 months) and old (20 months) male Fischer 344 rats. For comparison with other neural and non-neural tissue, AR binding in combined hypothalamus, preoptic area and amygdala (HPA), and muscle tissue from tongue and masseter were examined. Cytosol AR binding was significantly decreased in all three cranial nerve nuclei of old males. No age-related changes were observed in HPA or muscle. Cell nuclear AR binding was unaffected by age in all of the tissues analyzed. Neuron numbers in motor nuclei of the hypoglossal, facial and trigeminal nerves were compared between young and old rats. A significant decrease in neuron number was found only in the hypoglossal nucleus of old rats, indicating that neuronal loss is not a factor in the reduction of AR's in cranial nerve nuclei. It is suggested that the loss of AR's in cranial nerve nuclei of old rats contributes to the decline in male copulatory behavior by reducing responsiveness to sensory and motor cues.
McGinnis
M Y
MY
Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, NY 10029, USA.
Yu
W H
WH
D000375:Aging / Q000378:metabolism*; D000679:Amygdala / Q000378:metabolism; D000818:Animals; D002452:Cell Count; D017626:Cochlear Nucleus / Q000378:metabolism; D003391:Cranial Nerves / Q000502:physiology*; D007031:Hypothalamus / Q000378:metabolism; D008032:Limbic System / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009474:Neurons / Q000166:cytology; D011149:Pons / Q000378:metabolism; D011301:Preoptic Area / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D011944:Receptors, Androgen / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D011944:Receptors, Androgen; D013739:Testosterone; D007986:Luteinizing Hormone