[The therapeutic efficacy of the triase preparation in experimental pancreatic exocrine insufficiency].
The therapeutical efficiency of the new enzyme preparation Triase which contains microbial lipase, protease, and alpha-amylase was studied in dogs with experimental pancreatic failure. Enzyme maldigestion was made by bandaging the great pancreatic duct with pancreatic trypsin injection. The daily therapeutical dose of Triase (4 tablets) eliminated dyspepsia, creatorrhoea, restored body weight. But steatorrhoea was not abolished completely. The fecal fat content decreased to 22.1% versus 33.2% for untreated dogs following 8 weeks of the experiment. The enzyme therapy led to a more rapid reduction in blood amylase and lipase activities. This testifies that pancreatitis ran less severely.
Beliaev
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D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005243:Feces / Q000737:chemistry; D005260:Female; D008055:Lipids / Q000032:analysis; D008297:Male; D010182:Pancreatic Diseases / Q000188:drug therapy* / Q000201:enzymology; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D013607:Tablets; D013997:Time Factors
D008055:Lipids; D013607:Tablets; D010447:Peptide Hydrolases; C014864:tricholysine
Lechebnaia éffektivnost' preparata triazy pri éksperimental'noĭ ékzokrinnoĭ nedostatochnosti podzheludochnoĭ zhelezy.