Renal failure in a patient with chronic lymphocytic leukaemia treated with fludarabine.
The case history of a man with refractory chronic lymphocytic leukaemia who developed acute renal failure following treatment with fludarabine is presented. A renal biopsy specimen showed features of mesangiocapillary glomerulonephritis, a rare occurrence in chronic lymphocytic leukaemia. The rapid cytocidal action of fludarabine may result in the development of renal glomerular lesions when used to treat a well differentiated B cell malignancy.
Macheta
M P
MP
Annette Fox Haematology Unit, Bradford Royal Infirmary.
Parapia
L A
LA
Gouldesbrough
D R
DR
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015432:Glomerulonephritis, Membranoproliferative / Q000139:chemically induced*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014740:Vidarabine / Q000009:adverse effects / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D014740:Vidarabine; C024352:fludarabine