Antibody design: beyond the natural limits.
Dissection of antibody-antigen interactions requires a knowledge of antibody structure, the ability to model accurately the conformation of antibody-combining sites, and an understanding of the energetic factors governing the interactions. When this understanding has reached the point where the molecular shape and chemical character of a combining site necessary to define a particular specificity and binding requirement can be designed, the antibody repertoire will have been extended 'beyond the natural limits'.
Rees
A R
AR
School of Biology and Biochemistry, University of Bath, UK.
Staunton
D
D
Webster
D M
DM
Searle
S J
SJ
Henry
A H
AH
Pedersen
J T
JT
D000818:Animals; D000906:Antibodies / Q000737:chemistry* / Q000276:immunology; D000918:Antibody Specificity; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D015202:Protein Engineering
D000906:Antibodies