title: Nimodipine prevents early loss of hippocampal CA1 parvalbumin immunoreactivity after focal cerebral ischemia in the rat.
abstract: The effect of focal cerebral ischemia induced by middle cerebral artery occlusion on hippocampal interneurons containing the calcium-binding protein parvalbumin (PV) was studied in rats. Four hours after the onset of ischemia, a reduced number of PV-immunoreactive (-ir) neurons was observed in the lateral part of the CA1 region, while PV-ir was not altered in the CA2 and CA3 areas. Pretreatment with the L-type Ca2+ channel blocker nimodipine prevented the ischemia-induced loss of PV-ir in the CA1, suggesting a role for L-type voltage sensitive calcium channels in the mechanism of early neuronal alterations in the hippocampus CA1 region after focal cerebral ischemia.
authors.affiliation: Department of Animal Physiology, University of Groningen, The Netherlands.
authors.forename: Z
authors.initials: Z
authors.lastname: Benyó
authors.forename: G I
authors.initials: GI
authors.lastname: De Jong
authors.forename: P G
authors.initials: PG
authors.lastname: Luiten
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007150:Immunohistochemistry; D007395:Interneurons / Q000187:drug effects* / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009553:Nimodipine / Q000494:pharmacology*; D010320:Parvalbumins / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D010320:Parvalbumins; D009553:Nimodipine