[Determination by thermometric titrimetry of the thermodynamic parameters of water/n-octanol transfer of several non-steroidal anti-inflammatory drugs].
The calorimetric determination by thermometric titrimetry of the water/n-octanol transfer enthalpies of some non steroidic anti-inflammatory compounds is described. By combining the values obtained with that of the free enthalpies of transfer issuing from the values of corresponding log P, it is possible to determinate the transfer entropies of the solutes. The whole results of the show that almost the transfers are both enthalpy and entropy driven. They demonstrate the occurrence of three different mechanisms of transfer.
Burgot
G
G
Département d'Etudes de Physicochimie et Biocinétique des Pharmaco-systèmes, Faculté des Sciences pharmaceutiques et biologiques, Rennes.
Burgot
J L
JL
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000442:Octanols; D013816:Thermodynamics; D013821:Thermometers; D017186:Titrimetry; D014867:Water
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000442:Octanols; D014867:Water
Détermination par titrimétrie thermométrique des paramètres thermodynamiques de transfert eau/n-octanol de quelques anti-inflammatoires non stéroïdiens.