Amygdala kindling and immediate-early genes.
We examined if the first afterdischarge (AD) following a kindling stimulation to the amygdala is a necessary and/or sufficient stimulus for immediate-early gene (IEG) activation and whether activity that results in IEG expression in the amygdala was sufficient to cause activation in the hippocampus. We demonstrate that a single, short duration, AD results in activation of c-fos and egr-1 in the amygdala/piriform following a kindling stimulation to the amygdala. Conversely, considerably longer and perhaps more complex ADs are required for IEG induction in the hippocampus of amygdala kindled animals. These results suggest that a single AD is sufficient to activate c-fos and egr-1 in amygdala/piriform and establishes a putative role for IEGs in amygdala kindling.
Chiasson
B J
BJ
Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
Dennison
Z
Z
Robertson
H A
HA
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001483:Base Sequence; D004594:Electrophysiology; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D006624:Hippocampus / Q000502:physiology; D007696:Kindling, Neurologic; D008032:Limbic System / Q000502:physiology; D008969:Molecular Sequence Data; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D013997:Time Factors