Effect of the angiotensin-converting enzyme inhibitor alacepril on ventricular function and beta-adrenoceptor number in rabbits with aortic regurgitation.
This study was performed to determine the effects of the angiotensin-converting enzyme inhibitor alacepril on hemodynamic variables and beta-adrenoceptor number in rabbits with heart failure induced by aortic regurgitation. Aortic regurgitation was induced by perforation of the aortic valve in 12 rabbits. Sixty mg/kg of alacepril was administered by gastric tube for 7 days after manifestation of aortic regurgitation to 6 rabbits (group AR + A). The other 6 rabbits with aortic regurgitation were administered vehicle in the same fashion (group AR + C). Seven rabbits underwent sham operation (group S). One week after induction of aortic regurgitation left ventricular end-diastolic pressure was higher and cardiac output was lower in AR + C than in S. End-diastolic and end-systolic left ventricular diameter were larger and left ventricular weight was also higher in AR + C than in S. For each of these parameters, the opposite findings were obtained from a comparison of AR + A and S. Myocardial beta-adrenoceptor density and norepinephrine content were reduced in AR + C, but were restored in AR + A. These findings indicate that alacepril has beneficial effects on ventricular remodeling and function, and on sympatho-neuronal regulation in the volume-overloaded myocardium.
Yoshikawa
T
T
Department of Medicine, University School of Medicine, Tokyo, Japan.
Handa
S
S
Nagami
K
K
Suzuki
M
M
Wainai
Y
Y
Minami
T
T
Suzuki
K
K
Kitazawa
S
S
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001022:Aortic Valve Insufficiency / Q000378:metabolism / Q000503:physiopathology*; D002216:Captopril / Q000031:analogs & derivatives* / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D016276:Ventricular Function / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D002216:Captopril; C046835:alacepril