title: Concurrent agranulocytosis and acute hepatitis resulting from combination of classic neuroleptics and subsequent successful clozapine treatment.
abstract: Agranulocytosis and hepatotoxic reactions are rare but severe side-effects of neuroleptic treatment. This article presents the case of a schizophrenic patient who concurrently developed agranulocytosis and acute hepatic drug reaction as a result of a combination of chemically different neuroleptic drugs. After restoration the patient was successfully treated with clozapine for six months without the hematologic disorders recurring.
authors.affiliation: Department of Psychiatry, Freie Universität Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bauer
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced; D014150:Antipsychotic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D012559:Schizophrenia
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine