title: Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon.
abstract: Plasma levels of p53 protein were examined by an enzyme linked immunosorbent assay in 184 patients enrolled in a colonoscopy study. The mean levels among 47 individuals with normal colonoscopic examinations and no prior history of colonic neoplasia (0.12 ng/ml) and among 61 individuals with normal colonoscopic examinations and a prior history of colonic neoplasia (0.09 ng/ml) were similar. However, the mean levels among 54 individuals with newly diagnosed colonic adenomas (0.44 ng/ml) and 22 individuals with newly diagnosed colonic carcinomas (0.55 ng/ml) were statistically significantly elevated compared to the normal controls (P < 0.02). Among these tumor patients, the plasma levels tended to increase with increasing adenoma size and with increasing carcinoma stage, although these trends were not statistically significant. Defining a significant positive plasma level as any value greater than ten times background, the percentage of positive samples increased from 4% in the controls to 20% in the adenoma cases to 32% in the carcinoma cases. These results demonstrate that plasma p53 protein levels are elevated in a subgroup of individuals with colonic neoplasia.
authors.affiliation: Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Luo
authors.forename: A I
authors.initials: AI
authors.lastname: Neugut
authors.forename: G
authors.initials: G
authors.lastname: Garbowski
authors.forename: K A
authors.initials: KA
authors.lastname: Forde
authors.forename: M
authors.initials: M
authors.lastname: Treat
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: W P
authors.initials: WP
authors.lastname: Carney
authors.forename: P W
authors.initials: PW
authors.lastname: Brandt-Rauf
mesh_terms: D000236:Adenoma / Q000097:blood*; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000097:blood*; D003110:Colonic Neoplasms / Q000097:blood*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
chemical_list: D016159:Tumor Suppressor Protein p53