Tumor-localizing activity of porphyrin and its affinity to LDL, transferrin.
We spectrochemically analyzed 12 Ga-Metal porphyrins (Ga-Cn-P) with different degrees of hydrophobicity, and observed a close association between the in vivo Ga-Cn-P localization in the tumor and its affinity to transferrin and LDL. Image analysis of tumors with 99m-Tc-STA-R12, a porphyrin-scintigraphic agent, revealed STA-R12 localization in the tumor tissue alone about 1 h after intravenous infusion. Our results suggest the importance of endocytosis mediated by transferrin as well as LDL that have been reported as a mechanism of the tumor-localizing activity of porphyrin.
Nakajima
S
S
Division of Surgical Operation, Asahikawa Medical College, Hokkaido University, Sapporo, Japan.
Takemura
T
T
Sakata
I
I
D000818:Animals; D006224:Cricetinae; D005260:Female; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D008665:Metalloporphyrins / Q000493:pharmacokinetics*; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011877:Radionuclide Imaging; D013050:Spectrometry, Fluorescence; D017556:Technetium Compounds; D014018:Tissue Distribution; D014168:Transferrin / Q000378:metabolism*
C091730:13,17-bispropanoylaspartic acid-3-ethenyl-8-((N,N',N'', N'''-tetrakis(carboxylmethyl)diethylenetriaminoacetyloxy)methyl-2,7,12,18-tetramethylporphyrinato)manganese(III); D008077:Lipoproteins, LDL; D008665:Metalloporphyrins; D017556:Technetium Compounds; D014168:Transferrin