Immunohistology, cytogenetics, and molecular studies of small round cell tumors of childhood. A review.
Malignancies of childhood include a well-defined spectrum of hematolymphoid, organ specific (adrenal, kidney, liver), soft tissue, bone, and nervous system (central and peripheral) neoplasms with variable biology. Small round cell neoplasms, a subset of childhood malignancies, are histologically similar but differ markedly in their histogenesis, therapy, and prognosis. Traditionally, clinical information and light microscopy, with the aid of histochemistry and ultrastructural evaluation, establish a diagnosis or at least narrow the differential diagnosis. Additionally, immunohistology, cytogenetics, and molecular studies have become important in diagnosis and in defining phenotype/genotype, patient treatment modalities, and prognosis in specific cases. The 11;22 chromosomal translocation typifies Ewing's sarcoma, primitive neuroectodermal tumor, and Askin's tumor, as does the resultant chimeric transcript, while expression and amplification of N-myc oncogene are predictive of the prognosis in neuroblastoma. Furthermore, studies of genes and gene products are elucidating mechanisms of oncogenesis and tumor progression.
Winters
J L
JL
Department of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington 40536, USA.
Geil
J D
JD
O'Connor
W N
WN
D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000235:genetics / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D012509:Sarcoma / Q000235:genetics / Q000276:immunology / Q000473:pathology