title: The genetic regulation of apoptosis.
abstract: Dramatic advances, most of them within the past two years, have provided a picture of the genetic regulation of apoptosis in mammalian cells. Although much detail remains to be filled in, the general structure--concordant with programmed death in invertebrates--includes signalling systems, genetic determination of susceptibility, critical proteins capable of reversing or re-affirming the death sentence, and a common effector pathway driven by specific proteases.
authors.affiliation: Department of Pathology, University of Edinburgh Medical School, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Wyllie
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology