[Effect of paradentium polypeptide on the lipid peroxidation of the membranes and coagulation of erythrocytes in rats with spontaneous paradentitis].
The influence of alkaline polypeptides-cytomedines on the level of free radical oxidation of lipids, hemocoagulant, fibrinolytic and aggregative properties of erythrocytes in spontaneous parodontitis has been investigated. It has been established that the development of spontaneous parodontitis is accompanied by the activation of peroxide oxidation of cellular membranes, which results in the development of hypercoagulation and inhibition of fibrinolytic properties of erythrocytes, thereby intensifying the state of microcirculatory hemostasis. Polypeptide of the parodontium a modulating effect on the state of free-radical oxidation, improves antioxidant status of blood cells, stabilizes indices of erythrocytic link of hemostasis. The investigated cytomedines may be promising for treatment of the parodontium pathology.
Silenko
Iu I
IuI
Vesnina
L E
LE
Mishchenko
V P
VP
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D010518:Periodontitis / Q000188:drug therapy / Q000378:metabolism*; D010519:Periodontium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D010455:Peptides; C053892:cytomedins
Vliianie polipeptida parodonta na perekisnoe okislenie lipidov éritrotsitarnykh membran i koaguliatsionnuiu aktivnost Eritrotsitov u krys pri spontannom parodontite.