A hypotensive response induced by des-Arg9-bradykinin in young brown/Norway rats pretreated with endotoxin.
A hypotensive effect of intravenously injected des-Arg9-bradykinin was found in Brown/Norway strain young male rats which were pretreated with a small amount of endotoxin 24 h before the experiment, whereas the hypotensive effect of bradykinin was unaffected by the endotoxin. The potency of des-Arg9-bradykinin for the hypotensive effect was comparable to that of bradykinin. On the other hand, in endotoxin-pretreated aged rats, this effect of des-Arg9-bradykinin was not observed. Only during the intravenous infusion of des-Arg9[Leu8]bradykinin, a bradykinin B1 receptor antagonist, was the hypotensive effect of des-Arg9-bradykinin inhibited, whereas that of bradykinin was potentiated. After the end of infusion of des-Arg9[Leu8]bradykinin, the response to des-Arg9-bradykinin rapidly recovered. The results suggest the possibility that des-Arg9-bradykinin might play a role in inflammatory diseases.
Tokumasu
T
T
Department of Pharmacology, School of Pharmaceutical Science, Kitasato University, Tokyo, Japan.
Ueno
A
A
Oh-ishi
S
S
D000595:Amino Acid Sequence; D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D065168:Bradykinin Receptor Antagonists; D004347:Drug Interactions; D004926:Escherichia coli; D007022:Hypotension / Q000139:chemically induced*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D011914:Rats, Inbred BN; D013047:Specific Pathogen-Free Organisms
D065168:Bradykinin Receptor Antagonists; D008070:Lipopolysaccharides; C024626:bradykinin, des-Arg(9)-; C051090:bradykinin, Leu(8)-des-Arg(9)-; D001920:Bradykinin