Linkage of vancomycin and high-level gentamicin resistance genes on the same plasmid in a clinical isolate of Enterococcus faecalis.
A transferable 55-MDa plasmid which encoded resistance to both vancomycin and high concentrations of gentamicin was identified in a clinical isolate of Enterococcus faecalis. The plasmid hybridized with probes for the vanB and aac6'aph2" resistance genes. This is the first report of linkage of glycopeptide and high-level aminoglycoside resistance genes in an Enterococcus sp.
Woodford
N
N
Antibiotic Reference Unit, Central Public Health Laboratory, London, UK.
Jones
B L
BL
Baccus
Z
Z
Ludlam
H A
HA
Brown
D F
DF
D001483:Base Sequence; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000378:metabolism; D004352:Drug Resistance, Microbial / Q000235:genetics; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000235:genetics*; D005839:Gentamicins / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D010957:Plasmids / Q000235:genetics*; D014640:Vancomycin / Q000494:pharmacology*
D004269:DNA, Bacterial; D005839:Gentamicins; D014640:Vancomycin