title: Biopersistence of cerium in the human respiratory tract and ultrastructural findings.
abstract: For diagnostic purposes, mineralogical analysis was performed in bronchoalveolar lavage fluid and lung tissue from a 58-year-old patient previously exposed to asbestos and rare earth dusts. No significant retention of asbestos was demonstrated in lung tissue by light microscopy (asbestos bodies) or transmission electron microscopy analysis (uncoated fibers). Particles containing rare earth (cerium, lanthanum) and phosphorus were identified in alveolar macrophages in bronchoalveolar lavage fluid, and cerium-containing particles accounted for 70% of particles observed in the lung tissue. Ultrastructural analysis of lung tissue revealed the presence of particles containing cerium and phosphorus in interstitial macrophages and elastic fibers. These results suggest that rare earth is metabolized and should be considered as biopersistent in the human respiratory tract, since occupational inquiries revealed that exposure to cerium oxide abrasive powder had ceased at least 15 years earlier.
authors.affiliation: Clinique de Pathologie Respiratoire et Environnement, CHI Créteil, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Pairon
authors.forename: F
authors.initials: F
authors.lastname: Roos
authors.forename: P
authors.initials: P
authors.lastname: Sébastien
authors.forename: B
authors.initials: B
authors.lastname: Chamak
authors.forename: I
authors.initials: I
authors.lastname: Abd-Alsamad
authors.forename: J F
authors.initials: JF
authors.lastname: Bernaudin
authors.forename: J
authors.initials: J
authors.lastname: Bignon
authors.forename: P
authors.initials: P
authors.lastname: Brochard
mesh_terms: D001194:Asbestos / Q000032:analysis / Q000493:pharmacokinetics; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D002563:Cerium / Q000032:analysis / Q000493:pharmacokinetics*; D004391:Dust / Q000032:analysis; D004547:Elastic Tissue / Q000378:metabolism / Q000648:ultrastructure; D004577:Electron Probe Microanalysis; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D007811:Lanthanum / Q000032:analysis / Q000493:pharmacokinetics; D008168:Lung / Q000378:metabolism* / Q000648:ultrastructure*; D017563:Lung Diseases, Interstitial / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000378:metabolism / Q000648:ultrastructure; D016676:Macrophages, Alveolar / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D016273:Occupational Exposure; D010758:Phosphorus / Q000032:analysis / Q000493:pharmacokinetics; D013997:Time Factors
chemical_list: D004391:Dust; D001194:Asbestos; D010758:Phosphorus; D002563:Cerium; D007811:Lanthanum