The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11.
Cleft lip with or without cleft palate, CL(P), a common human birth defect, has a genetically complex etiology. An animal model with a similarly complex genetic basis is established in the A/WySn mouse strain, in which 20% of newborns have CL(P). Using a newly created congenic strain, AEJ.A, and SSLP markers, we have mapped a major CL(P)-causing gene derived from the A/WySn strain. This locus, here named clf1 (cleft lip) maps to Chromosome (Chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human CL(P) with the retinoic acid receptor alpha (RARA) locus.
Juriloff
D M
DM
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Mah
D G
DG
D000818:Animals; D002874:Chromosome Mapping; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D051379:Mice / Q000235:genetics*; D008805:Mice, Inbred A; D008817:Mice, Mutant Strains; D010375:Pedigree; D013045:Species Specificity
D005819:Genetic Markers