Nontraumatic fat embolism syndrome in sickle cell anemia.
A 14-year-old girl with sickle cell disease and nephrotic syndrome developed bone pain, followed by pulmonary edema, seizures, coma, and bilateral flaccid paralysis. Fat embolism syndrome was diagnosed by cranial magnetic resonance imaging and an exchange transfusion was performed. Within 3 months, all symptoms had resolved. It is concluded that fat embolism syndrome must be considered as a possible cause of acute neurologic deterioration in patients with sickle cell anemia.
Horton
D P
DP
Division of Pediatric Cardiology, University of California San Francisco 94143-0870, USA.
Ferriero
D M
DM
Mentzer
W C
WC
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D001853:Bone Marrow / Q000098:blood supply / Q000473:pathology; D003937:Diagnosis, Differential; D004620:Embolism, Fat / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007238:Infarction / Q000150:complications / Q000175:diagnosis; D002542:Intracranial Embolism and Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009404:Nephrotic Syndrome / Q000150:complications; D009460:Neurologic Examination