Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro.
The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.
Njar
V C
VC
Alao
T O
TO
Okogun
J I
JI
Raji
Y
Y
Bolarinwa
A F
AF
Nduka
E U
EU
D000818:Animals; D002478:Cells, Cultured; D005298:Fertility / Q000187:drug effects*; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007985:Leydig Cells / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D036702:Quassins; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000096:biosynthesis*
D036702:Quassins; D013739:Testosterone; D005900:Glaucarubin; C010317:quassin