Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat.
Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that the excitatory effect of low doses of GHB is mediated by a GHB receptor whereas the inhibitory effect of high doses of GHB involves a more complex mechanism.
Godbout
R
R
Département de psychiatrie Université de Montréal, Qué., Canada.
Jelenic
P
P
Labrie
C
C
Schmitt
M
M
Bourguignon
J J
JJ
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001567:Benzocycloheptenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D008297:Male; D009431:Neural Conduction / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012978:Sodium Oxybate / Q000494:pharmacology*; D013997:Time Factors
D000927:Anticonvulsants; D001567:Benzocycloheptenes; C066471:NCS 382; D012978:Sodium Oxybate