Non-islet cell tumour induced hypoglycaemia with acromegaloid facial and acral swelling.
The syndrome of non-islet cell tumour hypoglycaemia (NICTH) has been linked with the synthesis and secretion of 'big' IGF-II. We report a patient with a large pelvic clear cell sarcoma who developed recurrent severe hypoglycaemia and in addition presented with severe soft tissue facial swelling, skin tags and nuchal hyperpigmentation. After resection of the tumour serum 'big' IGF-II returned to normal and the acromegaloid skin changes remitted.
Trivedi
N
N
Department of Medical Endocrinology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India.
Mithal
A
A
Sharma
A K
AK
Mishra
S K
SK
Pandey
R
R
Trivedi
B
B
Daughaday
W H
WH
D000172:Acromegaly / Q000209:etiology*; D004487:Edema / Q000209:etiology; D005145:Face; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery; D018227:Sarcoma, Clear Cell / Q000097:blood / Q000150:complications* / Q000601:surgery
D007335:Insulin-Like Growth Factor II