Levels of soluble ICAM-1 in atopic dermatitis. A new marker for monitoring the clinical activity?
Levels of soluble intercellular adhesion molecule-1 (sICAM-1) were measured in sera from patients with an acute exacerbation of their atopic dermatitis (AD) (n = 16) on admission to and discharge from our department of dermatology. At admission, the sICAM-1 levels in sera from patients with AD were slightly higher than those of the blood donors (n = 100) and dropped at discharge significantly (P = 0.014) after improvement of the skin conditions. Therefore, sICAM-1 may be, together with soluble interleukin-2 receptor (sIL-2), eosinophilic cationic protein (ECP), and CD14, another marker for monitoring AD.
Wüthrich
B
B
Department of Dermatology, University Hospital Zurich, Switzerland.
Joller-Jemelka
H
H
Kägi
M K
MK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D003876:Dermatitis, Atopic / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012995:Solubility
D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1