Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae, a Hyphomonas strain, and Shewanella colwelliana.
The enzyme p-hydroxyphenylpyruvate hydroxylase (HPPH) is involved in pigmentation (pyomelanin) via homogentisic acid (HGA). Pyomelanin formation is correlated with HGA production and expression of HPPH in three disparate marine species: Vibrio cholerae, a Hyphomonas strain, and Shewanella colwelliana. Induction of pigmentation in V. cholerae 569B by nutrient limitation also correlated with production of HGA.
Kotob
S I
SI
Department of Microbiology, University of Maryland, College Park 20742, USA.
Coon
S L
SL
Quintero
E J
EJ
Weiner
R M
RM
D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000235:genetics / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D006092:Gram-Negative Facultatively Anaerobic Rods / Q000235:genetics / Q000378:metabolism; D006713:Homogentisic Acid / Q000378:metabolism*; D008386:Marine Biology; D008543:Melanins / Q000096:biosynthesis*; D009154:Mutation; D010858:Pigmentation; D014734:Vibrio cholerae / Q000235:genetics / Q000378:metabolism; D014871:Water Microbiology
D008543:Melanins; D015111:4-Hydroxyphenylpyruvate Dioxygenase; D006713:Homogentisic Acid