title: [Iminodimethylation, a method for pharmacomodulation in pyrimido-[3,4-a]-s-triazine series].
abstract: Primary amines react with two formaldehydes and compounds presenting two mobile hydrogen atoms, this reaction can be called iminodimethylation. This reaction can be used in order to perform a pharmacomodulation in the pyrimido [3,4-a]-s-triazine series. Against Epidermophyton floccosum, the activity is better when nitrogen 7 is not substituted, when the heroatom in position 2 is 0 instead of S and when an aromatic nucleus is directly linked to the nitrogen atom in position 3.
authors.affiliation: Laboratoire de Pharmacochimie et Biopharmacie, Faculté de Médecine et de Pharmacie de Rouen, Saint-Etienne-du-Rouvray.
authors.forename: S
authors.initials: S
authors.lastname: Menager
authors.forename: C
authors.initials: C
authors.lastname: Loire
authors.forename: T
authors.initials: T
authors.lastname: Petrakian
authors.forename: C
authors.initials: C
authors.lastname: Combet Farnoux
authors.forename: C
authors.initials: C
authors.lastname: Delabos
authors.forename: J
authors.initials: J
authors.lastname: Garnier
authors.forename: O
authors.initials: O
authors.lastname: Lafont
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology; D014227:Triazines / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014227:Triazines
vernacular_title: L'iminodiméthylation, une méthode de pharmacomodulation en série pyrimido [3,4-a]-s-triazinique.