Mechanisms and catalysts of disulfide bond formation in proteins.
The formation of disulphide bonds is an important co- and post-translational event in the biosynthesis of many extracellular proteins that is often coupled to protein folding. Progress in understanding how disulphide bonds form in model proteins provides insight into how the process can be manipulated to optimize the production of engineered proteins.
Creighton
T E
TE
European Molecular Biology Laboratory, Heidelberg, Germany.
Zapun
A
A
Darby
N J
NJ
D000595:Amino Acid Sequence; D001709:Biotechnology; D002384:Catalysis; D004220:Disulfides / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D015202:Protein Engineering; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D004220:Disulfides; D011506:Proteins