Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs: synthesis and activity against human cytomegalovirus.
2-Anilinopurines and 6-anilinopyrimidines bearing 3,4- or 3,5-dichloro substituents in the anilino ring inhibited virus-specific DNA synthesis by human cytomegalovirus (HCMV)-infected human embryonic lung (HEL) cells in culture. In general, active compounds had moderate to low selectivity for viral vs host cell DNA synthesis. Nucleoside and acyclonucleoside analogs of 2-(3,5-dichloroanilino)purines inhibited both HCMV and cellular DNA synthesis at similar concentrations. 2-Amino-4-chloro-6-(3,5-dichloroanilino)pyrimidine and several related compounds inhibited HCMV growth in yield reduction assays at concentrations that were nontoxic to HEL cells.
Medveczky
M
M
Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa 33612, USA.
Yang
T F
TF
Gambino
J
J
Medveczky
P
P
Wright
G E
GE
D000814:Aniline Compounds / Q000737:chemistry; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D006219:Halogens / Q000737:chemistry; D006801:Humans; D011684:Purine Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D011687:Purines / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000814:Aniline Compounds; D000998:Antiviral Agents; D006219:Halogens; D011684:Purine Nucleosides; D011687:Purines; D011743:Pyrimidines; D004259:DNA-Directed DNA Polymerase; C023650:aniline