[Perinatal pharmacotherapy and the risk of functional teratogenic defects].
Perinatal period, which is characterized by intensive histogenesis and cytodifferentiation of the already shaped organs, is a highly vulnerable phase for fetal/neonatal brain and immune system-organs with high similarity in receptor equipment. Even fine deviations in the programmed developmental processes induced by drugs initiate disorders in the formation of neural network, cytoarchitectonics and receptor-transmitter communication systems. This pathology is not evident at birth, but forms the basis for various functional defects of neuro-psycho-immunocompetence which become apparent gradually during further maturation or even in adulthood. Clinical recognition of such functional teratogenic action of drugs is hampered by the long time interval (upto decades) between the drug administration and its consequences, making the identification of causal relations very difficult. Consequently, experimental research is necessary under the precondition of adequate animal models with sufficient validity for the extrapolation on human level. The authors suggest the principles of such approach using drug application in neonatal rats with lifelong follow-up of behaviour, immune reactivity and brain biochemical analysis. The evaluation of functional teratogenic risk in three drugs used in the treatment of risk pregnancies and risk neonates (dexamethazone, fenoterol, diazepam) is presented.
Benesová
O
O
Psychiatrické centrum, Praha.
Tejkalová
H
H
Kristofiková
Z
Z
Dostál
M
M
Husek
P
P
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D003907:Dexamethasone / Q000009:adverse effects; D003975:Diazepam / Q000009:adverse effects; D005260:Female; D005280:Fenoterol / Q000009:adverse effects; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012307:Risk Factors
D005280:Fenoterol; D003907:Dexamethasone; D003975:Diazepam
Perinatální farmakoterapie a riziko funkcnĕ teratogenních defektů.