Isolation and characterization of fusaproliferin, a new toxic metabolite from Fusarium proliferatum.
A new toxic sesterterpene, named fusaproliferin, was purified from corn kernel cultures (120 mg/kg dry culture) of a strain of Fusarium proliferatum isolated from corn ear rot in northern Italy. The stain, designated ITEM-1494, also produced fumonisin B1 (1.500 mg/kg dry culture) and beauvericin (90 mg/kg dry culture), but not moniliformin. To monitor toxicity, the brine shrimp assay was used throughout the isolation procedure. Fusaproliferin had a molecular formula of C27H40O5, and it is the first sesterterpene isolated from a Fusarium species.
Ritieni
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A
Dipartimento di Scienza degli Alimenti dell'Università degli Studi di Napoli, Federico II, Portici, Italy.
Fogliano
V
V
Randazzo
G
G
Scarallo
A
A
Logrieco
A
A
Moretti
A
A
Mannina
L
L
Bottalico
A
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification; D001156:Artemia / Q000502:physiology; D002274:Carcinogens, Environmental / Q000032:analysis / Q000302:isolation & purification; D003470:Culture Media; D003503:Cyclobutanes / Q000032:analysis / Q000302:isolation & purification; D047630:Depsipeptides; D037341:Fumonisins; D005670:Fusarium / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009183:Mycotoxins / Q000032:analysis / Q000302:isolation & purification*; D010455:Peptides; D013729:Terpenes / Q000032:analysis / Q000302:isolation & purification*; D003313:Zea mays
D000900:Anti-Bacterial Agents; D002274:Carcinogens, Environmental; D003470:Culture Media; D003503:Cyclobutanes; D047630:Depsipeptides; D037341:Fumonisins; D009183:Mycotoxins; D010455:Peptides; D013729:Terpenes; C093577:fusaproliferin; C004456:beauvericin; C008539:moniliformin; C056933:fumonisin B1