title: Use of a digestive mucosal graft in urethroplasty. An experimental study--prospective utilization of the appendix mucosa.
abstract: Colic mucosa was used as a graft for urethral construction in 9 Sprague-Dawley rats. A urethrectomy was performed in each rat and then a urethroplasty built with the colic mucosa taken from a segmental colectomy. After 6 weeks to 3 months, all of these rats developed a typical urothelium. The digestive mucosa has been transformed into urothelium or acts as a stent to guide regrowth from each end. These results are encouraging, but the use of the appendix mucosa for hypospadias repair and for urethroplasty deserves further study.
authors.affiliation: Department of Pediatric Surgery, University of Rouen, Charles Nicolle Hospital, France.
authors.forename: T
authors.initials: T
authors.lastname: Lebret
authors.forename: F
authors.initials: F
authors.lastname: Gobet
authors.forename: M
authors.initials: M
authors.lastname: Dallaserra
authors.forename: P
authors.initials: P
authors.lastname: Mitrofanoff
mesh_terms: D000818:Animals; D001065:Appendix; D003106:Colon; D004195:Disease Models, Animal; D005260:Female; D007021:Hypospadias / Q000601:surgery; D007413:Intestinal Mucosa / Q000637:transplantation*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014521:Urethra / Q000473:pathology / Q000601:surgery*