title: From diabetic ketoacidosis to hyperglycemic hyperosmolar nonketotic syndrome: the spectrum of uncontrolled hyperglycemia in diabetes mellitus.
abstract: Diabetic ketoacidosis and hyperglycemic hyperosmolar nonketotic syndrome are two examples of uncontrolled hyperglycemia in diabetes mellitus that may prove life threatening. Both disorders result from a breakdown in glucose homeostasis caused by a relative or absolute insulin deficiency. This article compares and contrasts these two disorders with regard to pathogenesis, clinical presentation, and management.
authors.forename: T L
authors.initials: TL
authors.lastname: Jones
mesh_terms: D016883:Diabetic Ketoacidosis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D006706:Homeostasis; D006801:Humans; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D007328:Insulin / Q000627:therapeutic use
chemical_list: D007328:Insulin