Diazepinoquinazolines. Part II. Synthesis and pharmacological activity of some derivatives of 1,4-diazepino[2,1-b]quinazoline.
New derivatives of 1,4-diazepino[2,1-b]quinazoline were obtained. The diazepino quinazoline [IV] was obtained by the condensation of 2,5,6,7-tetrahydro-3-(methylthio)-1-phenyl-1H-1,4-diazepine with 5-chloroantranilic acid. Compounds was preparated in two steps from 2,3,4,5-tetrahydro-1,4-diazepino[2,1-b]quinazolin-7(1H)-one. The derivatives [II-IV], [VII], [VIII] were screened for their psychotropic activity.
Guryn
R
R
Department of Synthesis and Technology of Drugs, School of Medicine, Lódź, Poland.
Szadowska
A
A
Pakulska
W
W
D000818:Animals; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship
D011619:Psychotropic Drugs; D011799:Quinazolines; D001569:Benzodiazepines