Regulation of cyclic AMP-dependent Cl- channel in heart.
(1) alpha 1-Adrenoceptor stimulation inhibited the beta-adrenergic activation of Cl- current in guinea-pig ventricular cells. This alpha 1- and beta-adrenergic interaction appeared to be upstream in the cascade of adenylate cyclase activation. (2) Single Cl(-)-channel currents were recorded in cell-attached and excised outside-out patch membranes. Experiments were performed to investigate the dependence of channel behavior on the agonist concentrations.
Ehara
T
T
Department of Physiology, Saga Medical School, Japan.
Iyadomi
I
I
Hirahara
K
K
D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D000818:Animals; D018118:Chloride Channels / Q000502:physiology*; D000242:Cyclic AMP / Q000494:pharmacology*; D004533:Egtazic Acid / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D018118:Chloride Channels; D004533:Egtazic Acid; D000242:Cyclic AMP