Influence of subclinical nematodosis on the kinetic disposition of fenbendazole in buffaloes.
The disposition kinetics of fenbendazole was studied in buffaloes subclinically infected with gastrointestinal nematodes. There was significantly reduced uptake of the drug in infected animals compared to uninfected controls. The pH of the duodenal liquor was highly alkaline compared to the acidic pH in uninfected animals. The egg count in the faeces never became zero though the numbers were reduced to a great extent compared to pre-treatment values. The influence of the host's physiology on the reduced bioavailability of fenbendazole is discussed.
Mathur
A C
AC
Faculty of Veterinary Science and Animal Husbandry, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia, West Bengal.
Sanyal
P K
PK
Sarkar
S
S
D000723:Ancylostomatoidea; D000818:Animals; D002020:Buffaloes / Q000378:metabolism*; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D005273:Fenbendazole / Q000493:pharmacokinetics*; D006725:Hookworm Infections / Q000378:metabolism / Q000662:veterinary*; D008297:Male; D014253:Trichostrongylosis / Q000378:metabolism / Q000662:veterinary*; D014254:Trichostrongylus
D005273:Fenbendazole