[Natural factor splenin and mechanisms of its action].
The search of biologically active chemical compounds of the drug was carried out basing on the revealed lymphocytotropic property of splenin. A non-protein factor of the nucleoside origin was isolated from splenin by precipitation with mercury. It had a pronounced direct mitogenic effect on splein and thymic T-lymphocetes, being an active component of the drug. This factor increases the mass of lymphoid organs, promotes restoration of postradiation and steroidogenic lymphocytopenias.
Oliĭnyk
B V
BV
Sydorenko
O V
OV
Bohdanovych
L V
LV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D006454:Hemoglobins / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008208:Lymphatic System / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects* / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D013946:Thymopoietins / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism
D000276:Adjuvants, Immunologic; D001685:Biological Factors; D006454:Hemoglobins; D013946:Thymopoietins; C032841:thymopoietin III
Pryroda aktyvnoho chynnyka spleninu ta mekhanizm ĭoho diĭ.