Premature centromere division: a possible manifestation of chromosome instability.
Retrospective analysis of "routine" chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxia-teleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.
Méhes
K
K
Department of Pediatrics, University Medical School, Pécs, Hungary.
Bühler
E M
EM
D000293:Adolescent; D001260:Ataxia Telangiectasia / Q000150:complications / Q000235:genetics; D016022:Case-Control Studies; D002503:Centromere / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D005199:Fanconi Anemia / Q000150:complications / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000150:complications / Q000235:genetics; D005333:Fetus / Q000002:abnormalities; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D011247:Pregnancy; D012189:Retrospective Studies