title: The "universal" leucine codon CTG in the secreted aspartyl proteinase 1 (SAP1) gene of Candida albicans encodes a serine in vivo.
abstract: A number of Candida species possess a tRNA(Ser)-like species that recognizes CTG codons that normally specify leucine (Leu) in the universal code of codon usage. Mass spectrometry and Edman sequencing of peptides from the secreted aspartyl proteinase isoenzyme (Sap1) demonstrate that positions specified by the CTG codon contain a nonmodified serine (Ser) in Candida albicans.
authors.affiliation: Department of Stomatology, University of California-San Francisco, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: White
authors.forename: L E
authors.initials: LE
authors.lastname: Andrews
authors.forename: D
authors.initials: D
authors.lastname: Maltby
authors.forename: N
authors.initials: N
authors.lastname: Agabian
mesh_terms: D016282:Aspartic Acid Endopeptidases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002176:Candida albicans / Q000235:genetics*; D003062:Codon / Q000235:genetics*; D005815:Genetic Code; D007930:Leucine / Q000235:genetics*; D010446:Peptide Fragments / Q000737:chemistry; D012362:RNA, Transfer, Ser / Q000378:metabolism; D017421:Sequence Analysis; D012694:Serine / Q000235:genetics*
chemical_list: D003062:Codon; D010446:Peptide Fragments; D012362:RNA, Transfer, Ser; D012694:Serine; D016282:Aspartic Acid Endopeptidases; C086390:SAP1 protein, Candida albicans; D007930:Leucine