Experimental induction of primitive neuro-ectodermal tumours in rats: a re-appraisement of the ENU-model of neurocarcinogenesis.
A series of 122 experimental brain tumours, induced in the Wistar rat by means of prenatal exposition to ethyl-nitrosourea, were studied with histological, immunohistochemical and ultrastructural techniques. Although with conventional histological techniques, most of the induced tumours showed morphological features suggesting their classification as malignant schwannomas or oligodendroglioma-like neoplasms, their study by means of immunohistochemistry and electron microscopy suggested that they are, in fact, primitive neuroectodermal tumours, with a tendency toward neuronal differentiation. This finding obliges us to re-appraise the ethyl-nitrosourea model of neurocarcinogenesis and to consider its possible usefulness for the experimental study of therapeutic approaches with potential applications in human neuro-ectodermal neoplasms.
Vaquero
J
J
Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Oya
S
S
Coca
S
S
Zurita
M
M
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000473:pathology; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000473:pathology; D005038:Ethylnitrosourea; D005260:Female; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D018242:Neuroectodermal Tumors, Primitive / Q000139:chemically induced* / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D014408:Biomarkers, Tumor; D005038:Ethylnitrosourea