Glial uptake of intracerebroventricularly injected D-serine in the rat brain: an immunocytochemical study.
Recent studies have shown that free D-serine, an agonist for the N-methyl-D-aspartate receptor, is present in the forebrain of rats. In present study, we raised antibodies against D-serine and examined the distribution of both endogenous and intracerebroventricularly administered D-serine in the rat forebrain by an immunocytochemical method. D-Serine-like immunoreactive cells were found in glial cells in the brains of the rats injected with D-serine into the lateral ventricle. No immunoreactive cells were seen in the brains of untreated rats. The results suggest that glial cells may accumulate and catabolize D-serine to regulate the concentration of this neuroactive amino acid in the forebrain.
Wako
K
K
Department of Anatomy II, Mie University School of Medicine, Japan.
Ma
N
N
Shiroyama
T
T
Semba
R
R
D000818:Animals; D003337:Corpus Callosum; D007150:Immunohistochemistry / Q000379:methods*; D007278:Injections, Spinal; D008297:Male; D009457:Neuroglia / Q000502:physiology*; D016548:Prosencephalon / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012694:Serine / Q000378:metabolism*
D012694:Serine