Centrin, centrosomes, and mitotic spindle poles.
Centrin is a ubiquitous protein component of centrosomes and mitotic spindle poles. cDNA clones encoding centrin have been identified from vertebrate sources, and their sequences demonstrate that centrin is a highly conserved member of the EF-hand superfamily of calcium-binding proteins. Analysis of yeast and Chlamydomonas centrin mutants and experimental studies suggest that centrin has an essential role in the duplication of the centrosomes during the cell cycle, and in microtubule severing.
Salisbury
J L
JL
Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Rochester, MN 55905, USA.
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002118:Calcium / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000032:analysis*; D002453:Cell Cycle / Q000502:physiology; D018385:Centrosome / Q000737:chemistry*; D002868:Chromosomal Proteins, Non-Histone / Q000032:analysis*; D018076:DNA, Complementary / Q000235:genetics*; D008969:Molecular Sequence Data; D008941:Spindle Apparatus / Q000737:chemistry*
D002135:Calcium-Binding Proteins; D002868:Chromosomal Proteins, Non-Histone; D018076:DNA, Complementary; C056608:caltractin; D002118:Calcium