[Prognosis of epidermoid carcinoma of oropharyngeolaryngeal region].
Knowledge of pronostic factors is essential for assessment of therapeutic procedures and for individual treatment selection and adjustment for patient with squamous cell carcinomas of the head and neck. This paper reviews known clinical, histological and biological prognostic factors and their prognostic significance in predicting survival, response to treatment and locoregional and distant recurrences. Most significant criteria include tumor site and extension, absence or presence of cervical lymph nodes and their location, size and mobility. Histological, disease-related factors include number and location of involved nodes, and extra-capsular spread, which is the most significant independent factor. Response to treatment is an essential factor which should be used to alter or complement the treatment plan. Other treatment-related factors include technical parameters that can impact the outcomes and should be taken into account when assessing treatment procedures. Preliminary studies suggest that biological factors may be used as efficient predictors within the next few years but they are still under evaluation and therefore are not to be used in routine practice. They are expected to improve prediction of response to radiotherapy and chemotherapy as well as prediction of the risk of distant metastases and of metachronous head and neck cancers.
Renaud-Salis
J L
JL
Service de chirurgie cervico-faciale, Institut Bergonié, Bordeaux.
D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D011379:Prognosis
Pronostic des carcinomes épidermoïdes oro-pharyngo-laryngés.