Tumor necrosis factor-alpha and interleukin-1 beta in cerebrospinal fluid of patients with coccidioidal meningitis during therapy with fluconazole. National Institute of Allergy and Infectious Diseases Mycoses Study Group.
The levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1 beta in the cerebrospinal fluid (CSF) of 66 patients with coccidioidal meningitis during therapy with fluconazole were measured by ELISA. The median concentration of TNF-alpha was 15.2 pg/mL for 322 samples; for IL-1 beta, it was 4.7 pg/mL for 316 samples. There were no significant changes in the level of either cytokine over 24 months of follow-up nor was there an association between the initial CSF concentrations of TNF-alpha and IL-1 beta and subsequent fluconazole treatment failure. Over time, concentrations of IL-1 beta were significantly associated with both clinical symptoms and white blood cell counts in CSF. These results indicate that CSF levels of TNF-alpha and IL-1 beta are relatively low compared with those associated with acute bacterial meningitis.
Ampel
N M
NM
Medical Service VA Medical Center, Tucson, AZ 85723, USA.
Ahmann
D R
DR
Delgado
K L
KL
Galgiani
J N
JN
Cloud
G A
GA
D003047:Coccidioidomycosis / Q000134:cerebrospinal fluid*; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D007375:Interleukin-1 / Q000134:cerebrospinal fluid*; D016921:Meningitis, Fungal / Q000134:cerebrospinal fluid* / Q000188:drug therapy*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D015725:Fluconazole