title: [Bactericidal activity of ciprofloxacin and sparfloxacin. Comparison with others active antibiotics against Pasteurella multocida].
abstract: Bactericidal activities of ciprofloxacin and sparfloxacin were compared to other antibiotics active against human isolates of Pasteurella multocida. Three human isolates of Pasteurella multocida were used for killing-curve studies with ciprofloxacin and sparfloxacin comparatively to others antibiotics. At 2x the MIC, ciprofloxacin and sparfloxacin exhibited a killing of more than 99.9% of the initial viable cells that was achieved within 6 h of incubation. These activities were faster than those of amoxycillin and cefpodoxime. No regrowth was observed after 24 h of incubation. Doxycycline and clarithromycin used at MICx2 had no bactericidal activities. It was concluded that fluoroquinolones, namely ciprofloxacin and sparfloxacin, can be considered having good bactericidal activity against P. multocida.
authors.affiliation: Laboratoire de Bactériologie-Virologie, Faculté de Médecine de Rennes.
authors.forename: C
authors.initials: C
authors.lastname: Gastine
authors.forename: P Y
authors.initials: PY
authors.lastname: Donnio
authors.forename: M F
authors.initials: MF
authors.lastname: Travert
authors.forename: J L
authors.initials: JL
authors.lastname: Avril
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D015296:Ceftizoxime / Q000031:analogs & derivatives / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024841:Fluoroquinolones; D066298:In Vitro Techniques; D016979:Pasteurella multocida / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology*; D000097623:Cefpodoxime
chemical_list: D000658:Amoxicillin; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015296:Ceftizoxime; D002939:Ciprofloxacin; D024841:Fluoroquinolones; D015363:Quinolones; D000097623:Cefpodoxime; C061363:sparfloxacin
vernacular_title: Activité bactéricide de la ciprofloxacine et de la sparfloxacine. Comparaison avec celle des autres antibiotiques actifs sur Pasteurella multocida.