title: 2-oxoglutarate-dependent dioxygenase and related enzymes: biochemical characterization.
abstract: Hydroxylation reactions are catalysed by a few major subclasses of enzymes which are ubiquitously distributed in nature. Dioxygenases generally occur as soluble enzymes where they catalyse a diversity of oxygenation reactions in a large number of metabolic pathways in animals, plants and micro-organisms. This review discusses recent advances in the biochemistry and molecular biology of dioxygenases occurring in different biological systems.
authors.affiliation: Département de Sciences Biologiques, Université de Montréal, Québec, Canada.
authors.forename: E
authors.initials: E
authors.lastname: De Carolis
authors.forename: V
authors.initials: V
authors.lastname: De Luca
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D005658:Fungi / Q000201:enzymology; D006801:Humans; D007656:Ketoglutaric Acids / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D010944:Plants / Q000201:enzymology*; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity
chemical_list: D007656:Ketoglutaric Acids; D006899:Mixed Function Oxygenases