title: [Simultaneous occurrence of medullary and papillary carcinoma in the same thyroid lobe].
abstract: A clinical case of combination between papillary and medullary carcinomas situated in one lobe of thyroid gland is represented. The patient was a 66 year-old female with clinical data for goiter and thyroid scanning revealing a functioning (hot) nodule. Immunohistochemical and ultrastructural evaluation, alongside with routine histological staining were applied for identification of both tumors. Papillary carcinoma cells proved to be pancytokeratin positive and negative for carcinoembryonic antigen and calcitonin. Medullary carcinoma cells showed expression of carcinoembryonic antigen and calcitonin and histochemical methods demonstrated stromal deposits of amyloid. The opportunities for concomitant malignant transformation of thyroid follicular and parafollicular (C) cells are discussed.
authors.affiliation: Lehrstuhl für pathologische Anatomie und Zytopathologie, Medizinische Fakultät, Sofia, Bulgarien.
authors.forename: K
authors.initials: K
authors.lastname: Meinhard
authors.forename: I
authors.initials: I
authors.lastname: Michailov
mesh_terms: D000368:Aged; D018276:Carcinoma, Medullary / Q000473:pathology* / Q000601:surgery; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D005260:Female; D006042:Goiter / Q000150:complications / Q000473:pathology; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology*
vernacular_title: Gleichzeitiges Vorhandensein von medullärem und papillärem Karzinom in demselben Schilddrüsenlappen.