title: A biologically active lipophilic flavonol from Tanacetum parthenium.
abstract: A new lipophilic flavonol, 6-hydroxykaempferol 3,7,4'-trimethyl ether, called tanetin, has been characterized in the leaf, flower and seed of feverfew, Tanacetum parthenium. It co-occurs with the known 6-hydroxykaempferol 3,7-dimethyl ether, quercetagetin 3,7-dimethyl ether and quercetagetin 3,7,3'-trimethyl ether. Pharmacological tests indicate that tanetin could contribute to the anti-inflammatory properties of feverfew by inhibiting the generation of pro-inflammatory eicosanoids, although it is unlikely to be the only biologically active compound within the plant. Water soluble flavone glycosides were detected in the leaves and identified as apigenin 7-glucuronide, luteolin 7-glucuronide, luteolin 7-glucoside and chrysoeriol 7-glucuronide.
authors.affiliation: Department of Botany, School of Plant Sciences, University of Reading, Whiteknights, Berkshire, U.K.
authors.forename: C A
authors.initials: CA
authors.lastname: Williams
authors.forename: J R
authors.initials: JR
authors.lastname: Hoult
authors.forename: J B
authors.initials: JB
authors.lastname: Harborne
authors.forename: J
authors.initials: J
authors.lastname: Greenham
authors.forename: J
authors.initials: J
authors.lastname: Eagles
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D044948:Flavonols; D005965:Glucuronates / Q000737:chemistry / Q000302:isolation & purification; D019684:Magnoliopsida / Q000737:chemistry*; D013058:Mass Spectrometry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005419:Flavonoids; D044948:Flavonols; D005965:Glucuronates; C093059:tanetin