title: Intransal or intragastric immunization with proteosome-Shigella lipopolysaccharide vaccines protects against lethal pneumonia in a murine model of Shigella infection.
abstract: Mice immunized intransally or intragastrically with proteosome vaccines containing either Shigella sonnei or S. flexneri 2a lipopolysaccharide were protected against lethal pneumonia caused by homologous organisms in an experimental murine intranasal challenge model of Shigella infection. Histopathological analysis demonstrated that immunization also protected against the progressive lesions resulting from invasion of the pulmonary mucosa by S. sonnei. These data show that mucosal proteosome-lipopolysaccharide vaccines can protect against lethal bacterial pneumonia and indicate that such vaccines are promising candidates for protection against intestinal shigellosis.
authors.affiliation: Department of Enteric Infections, Walter Reed Army Institute of Research, Washington, D.C. 20307, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Mallett
authors.forename: T L
authors.initials: TL
authors.lastname: Hale
authors.forename: R W
authors.initials: RW
authors.lastname: Kaminski
authors.forename: T
authors.initials: T
authors.lastname: Larsen
authors.forename: N
authors.initials: N
authors.lastname: Orr
authors.forename: D
authors.initials: D
authors.lastname: Cohen
authors.forename: G H
authors.initials: GH
authors.lastname: Lowell
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D004405:Dysentery, Bacillary / Q000517:prevention & control*; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D018410:Pneumonia, Bacterial / Q000517:prevention & control*; D012760:Shigella / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D008070:Lipopolysaccharides