title: Isolation of decomposition products of tylosin using liquid chromatography.
abstract: Decomposition products of tylosin A were isolated using open column chromatography and preparative liquid chromatography. Two decomposition products, formed in slightly alkaline medium, were identified as epimers of tylosin A aldol, one of which has been described previously. Another decomposition product was formed on exposure of a tylosin A solution to light. Isomerization of the double bond between C12-C13 takes place, resulting in the formation of the hitherto unreported isotylosin A.
authors.affiliation: Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Paesen
authors.forename: W
authors.initials: W
authors.lastname: Cypers
authors.forename: R
authors.initials: R
authors.lastname: Busson
authors.forename: E
authors.initials: E
authors.lastname: Roets
authors.forename: J
authors.initials: J
authors.lastname: Hoogmartens
mesh_terms: D002240:Carbohydrate Sequence; D002853:Chromatography, Liquid / Q000379:methods*; D008969:Molecular Sequence Data; D013056:Spectrophotometry, Ultraviolet; D015645:Tylosin / Q000737:chemistry*
chemical_list: D015645:Tylosin