Recurring genetic aberrations in cancer cells: chromosomes as potential targets for nuclear medicine imaging.
Many chromosomal aberrations in neoplastic tumor cells are specific for tumor types. These aberrations include both gains and losses of chromosomes (or chromosome regions) as well as translocations. The use of molecular probes to identify these aberrations may have potential application in the design of various cancer therapies that target the aberrant genes.
Rowley
J D
JD
Department of Medicine, University of Chicago Medical Center, IL 60637-1470, USA.
D002869:Chromosome Aberrations; D015342:DNA Probes; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000175:diagnosis / Q000235:genetics; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D011868:Radioisotopes; D014178:Translocation, Genetic
D015342:DNA Probes; D011868:Radioisotopes