Essential fatty acid preparation (SR-3) rehabilitates learning deficits induced by AF64A and 5,7-DHT.
The purpose of this study was to examine the possible effects of a novel mixture of fatty acids, SR-3 (a specific ratio between alpha-linolenic and linoleic acids) on learning deficits induced by cholinergic (AF64A) and serotonergic (5,7-DHT) neurotoxins in rats. I.c.v. AF64A and 4th ventricle administration of 5,7-DHT induce severe learning deficit using the Morris Water Tank. Three weeks of treatment with SR-3 rehabilitated the learning capacity of rats. However, learning deficits induced by a lesion in area postrema was not rehabilitated by SR-3. The mode of action of SR-3 is unknown. We propose that this combination of free fatty acids modulates the composition of neuronal membrane lipids and allows better neuronal communication.
Yehuda
S
S
Dept of Psychology, Bar Ilan University, Ramat Gan, Israel.
Carraso
R L
RL
Mostofsky
D I
DI
D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology*; D007859:Learning Disabilities / Q000139:chemically induced; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014363:Tryptamines / Q000494:pharmacology*
D001388:Aziridines; D005227:Fatty Acids; D009466:Neuromuscular Blocking Agents; D014363:Tryptamines; C030820:tryptamine; C044894:ethylcholine aziridinium; D002794:Choline