Monocyte chemotactic protein 1 is released during lethal and sublethal bacteremia in baboons.
The chemokine monocyte chemotactic protein 1 (MCP-1) is a cytokine with chemotactic activity specific for mononuclear phagocytes. To investigate the possible involvement of MCP-1 in the pathogenesis of sepsis, its course was studied in baboons challenged intravenously with a sublethal or lethal dose of Escherichia coli. Levels of MCP-1 started to increase in both groups of animals 2 h after injection of E. coli, reaching peak levels 4 and 6 h after a sublethal (186 +/- 21 ng/mL) or a lethal (213 +/- 24 ng/mL) dose, respectively. Levels of MCP-1 correlated significantly with plasma levels of another chemokine, interleukin-8 (IL-8; r = .826. P < .001), suggesting that common stimuli mediate the release of both cytokines in this model.
Jansen
P M
PM
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam.
van Damme
J
J
Put
W
W
de Jong
I W
IW
Taylor
F B
FB
Hack
C E
CE
D000818:Animals; D016470:Bacteremia / Q000097:blood*; D018932:Chemokine CCL2; D002630:Chemotactic Factors / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D004927:Escherichia coli Infections / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D010215:Papio; D013997:Time Factors
D018932:Chemokine CCL2; D002630:Chemotactic Factors; D016207:Cytokines; D016209:Interleukin-8