title: The czc operon of Alcaligenes eutrophus CH34: from resistance mechanism to the removal of heavy metals.
abstract: The plasmid-borne czc operon ensures for resistance to Cd2+, Zn2+ and Co2+ ions through a tricomponent export pathway and is associated to various conjugative plasmids of A. eutrophus strains isolated from metal-contaminated industrial areas. The czc region of pMOL30 was reassessed especially for the segments located upstream and downstream the structural genes czc CBA. In cultures grown with high concentrations of heavy metals, czc-mediated efflux of cations is followed by a process of metal bioprecipitation. These observations led to the development of bioreactors designed for the removal of heavy metals from polluted effluents.
authors.affiliation: Flemish Institute for Technological Research (VITO), Mol, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Diels
authors.forename: Q
authors.initials: Q
authors.lastname: Dong
authors.forename: D
authors.initials: D
authors.lastname: van der Lelie
authors.forename: W
authors.initials: W
authors.lastname: Baeyens
authors.forename: M
authors.initials: M
authors.lastname: Mergeay
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000502:physiology; D000421:Alcaligenes / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D001483:Base Sequence; D001673:Biodegradation, Environmental; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000502:physiology; D005798:Genes, Bacterial / Q000235:genetics*; D008670:Metals / Q000493:pharmacokinetics; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics
chemical_list: D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; D008670:Metals