[Biological activity of the poly(G).poly(C) complex, modified by divalent platinum compounds].
Modification of poly(G).poly(C) with cys-diaminodichloroplatinum (cys-DDP) at the level of rb = 0.02 increased the in vivo antiviral and interferon-inducing activity of the complex, in contrast to the data reported for complex poly(G).poly(C). Antiinfluenza activity in this case depends on the method of modification and increases more intensively when a ready complex is treated with cys-DDP, as against treatment of poly(G) alone before the formation of a complex with poly(C). If rb is increased, the activity reduces again. Modification with trans-DDP at rb = 0.02 also leads to an increase of antiinfluenza activity of poly(G).poly(C), but mainly after pretreatment of poly(G).
Aksenov
O A
OA
Murina
E A
EA
Kogan
E M
EM
Platonova
G A
GA
Sidorova
N S
NS
Timkovskiĭ
A L
AL
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002945:Cisplatin / Q000737:chemistry*; D009980:Influenza A virus / Q000187:drug effects*; D007369:Interferon Inducers / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D011066:Poly C / Q000737:chemistry / Q000494:pharmacology*; D011068:Poly G / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D007369:Interferon Inducers; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; D002945:Cisplatin
Biologicheskaia aktivnost' kompleksa poli(G).poli(C), modifitsirovannogo soedinenimi dvukhvalentnoĭ platiny.