Passive immunization of insulin-like growth factor (IGF)-1 and of IGF-1 and IGF-2 in chickens.
The effects of passive immunization against IGF-1 either alone, or together with immunization against IGF-2, on growth and metabolism were examined in chickens. Immunization against IGF-1 alone had no effect upon any aspect of growth, carcass composition, efficiency of energy utilization or hormone concentrations studied. Immunization against both IGF-1 and IGF-2 together resulted in a lighter final body weight (P < 0.05) compared with controls. Immunization against both IGFs together decreased abdominal fat content (P < 0.05) and resulted in a heavier mean spleen weight (P < 0.01). The joint immunization was also associated with elevated plasma T3 concentrations. These data may indicate a role for IGF-2, but not for IGF-1, in fat metabolism in chickens.
Spencer
G S
GS
Ruakura Agricultural Centre, Hamilton, New Zealand.
Decuypere
E
E
Buyse
J
J
Hodgkinson
S C
SC
Bass
J J
JJ
Zeman
M
M
D000273:Adipose Tissue / Q000254:growth & development / Q000276:immunology; D000818:Animals; D001823:Body Composition / Q000276:immunology; D001835:Body Weight / Q000276:immunology; D002060:Bursa of Fabricius / Q000254:growth & development / Q000276:immunology; D002645:Chickens / Q000254:growth & development* / Q000276:immunology; D003429:Cross Reactions; D004734:Energy Metabolism / Q000276:immunology; D006321:Heart / Q000254:growth & development; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000276:immunology; D007334:Insulin-Like Growth Factor I / Q000276:immunology* / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000276:immunology* / Q000502:physiology; D008099:Liver / Q000254:growth & development / Q000276:immunology; D008297:Male; D024510:Muscle Development; D009132:Muscles / Q000276:immunology; D009929:Organ Size / Q000276:immunology; D012756:Sheep; D013154:Spleen / Q000254:growth & development / Q000276:immunology
D007106:Immune Sera; D007074:Immunoglobulin G; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II