title: [Thyroid disease and multiple autoimmune syndromes. Clinical and immunogenetic aspects apropos of 11 cases].
abstract: The authors report eleven cases of multiple auto-immune syndrome, concerning a total of 15 different auto-immune diseases. This study suggests that auto-immune thyroid disorders (Graves' disease or hypothyroidism resulting from Hashimoto's thyroiditis) are a common feature of multiple auto-immune syndromes, while antithyroid antibodies are constant among our patients. Sjögren's syndrome is also very prevalent, and seems to be non-randomly associated with auto-immune thyroid disorders, a fact which suggests common aetiological factors. Among other auto-immune disorders, the antiphospholipid syndrome has been diagnosed twice. A genetic predisposition to multiple auto-immune syndrome is obvious, as shown by a familial history of auto-immune disorders (found in more than half of the cases), and a predominant HLA phenotype, B8 and/or DR3. The authors plead for a systematic enquiry for multiple auto-immune syndrome in patients with auto-immune thyroid disorders and a family history of auto-immune disorders.
authors.affiliation: Service de médecine interne, hôpital Nord, CHU de Saint-Etienne, France.
authors.forename: K
authors.initials: K
authors.lastname: Bouchou
authors.forename: M
authors.initials: M
authors.lastname: André
authors.forename: P
authors.initials: P
authors.lastname: Cathébras
authors.forename: A
authors.initials: A
authors.lastname: Klisnick
authors.forename: J
authors.initials: J
authors.lastname: Schmidt
authors.forename: O
authors.initials: O
authors.lastname: Aumaître
authors.forename: H
authors.initials: H
authors.lastname: Rousset
mesh_terms: D000328:Adult; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D015803:HLA-DR3 Antigen / Q000032:analysis; D006801:Humans; D007125:Immunogenetics; D008875:Middle Aged; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology; D013577:Syndrome; D013967:Thyroiditis, Autoimmune / Q000235:genetics* / Q000276:immunology; D014820:Vitiligo / Q000235:genetics / Q000276:immunology
chemical_list: D015803:HLA-DR3 Antigen
vernacular_title: Pathologie thyroïdienne et syndromes auto-immuns multiples. Aspects clinique et immunogénétique à propos de 11 observations.