Inhibition of lordosis in female hamsters and rats by 8-OH-DPAT treatment.
In the present experiments, the ability of the 5-HT1A agonist, 8-OH-DPAT, to inhibit lordosis was determined in ovariectomized hamsters and rats under various hormonal conditions. Systemic administration of 8-OH-DPAT (0.25 mg/kg) significantly inhibited lordosis duration in ovariectomized hamsters treated on 3 consecutive wk with estradiol benzoate (3 or 10 micrograms) and progesterone (500 micrograms). Similarly, systemic administration of 8-OH-DPAT (0.25 mg/kg) significantly inhibited lordosis frequency in ovariectomized rats treated on 3 consecutive wk with estradiol benzoate (0.25, 0.5, or 25 micrograms for 3 days) and progesterone (500 micrograms), although females treated with the higher doses of estrogen were slightly less inhibited on the second and third wk of testing. Results indicate that the 5-HT1A agonist, 8-OH-DPAT, effectively inhibited lordosis in female hamsters, as well as female rats, under varied hormonal conditions.
Hebert
T J
TJ
Department of Psychology, Tulane University, New Orleans, LA 70118, USA.
Menard
C S
CS
Dohanich
G P
GP
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D010052:Ovariectomy; D011187:Posture; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects
C074283:estradiol 3-benzoate; D011374:Progesterone; D004958:Estradiol; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin