title: Recombinant polymeric IgG: an approach to engineering more potent antibodies.
abstract: IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector functions mediated through gamma specific Fc receptors. Using a generalizable technique we have produced IgM-like polymers of IgG that possess both the Fc gamma receptor binding properties of IgG and the more potent complement activity of IgM.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024.
authors.forename: R I
authors.initials: RI
authors.lastname: Smith
authors.forename: S L
authors.initials: SL
authors.lastname: Morrison
mesh_terms: D000818:Animals; D003172:Complement C1 / Q000378:metabolism; D015922:Complement C1q / Q000378:metabolism; D005818:Genetic Engineering; D006207:Half-Life; D006461:Hemolysis; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D011961:Receptors, Fc / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D003172:Complement C1; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011961:Receptors, Fc; D011994:Recombinant Proteins; D015922:Complement C1q