title: Torulopsis glabrata vaginitis.
abstract: OBJECTIVE
  To study the sociodemographic risk factors and clinical features of Torulopsis glabrata vaginal infection.
  
  
  METHODS
  We evaluated the sociodemographic and clinical characteristics of 86 consecutive symptomatic women attending a vaginitis clinic and isolated T glabrata. Case patients were compared with a control group of 174 asymptomatic women with negative vaginal cultures and an additional group of 625 symptomatic women with vaginal cultures positive for Candida albicans. In addition, the sensitivity of the isolates to the more common antimycotic agents used was tested by the modified Kirby-Bauer method.
  
  
  RESULTS
  Patients with T glabrata vaginal infection were from lower socioeconomic backgrounds and had less education. They were more likely to use vaginal tampons and to be seropositive for human immunodeficiency virus than were negative controls. Compared with C albicans infection, T glabrata was more frequent among women over 38 years of age and in those with less education and of lower social class. In logistic regression analysis, T glabrata was associated more frequently with recurrent vaginal candidiasis than was C albicans (odds ratio 2.46, 95% confidence interval 1.33-4.54; P = .004). Six of the 86 (7%) T glabrata isolates and none of the C albicans isolates (P < .001 by Fisher exact test) were resistant to the imidazole derivatives tested.
  
  
  CONCLUSIONS
  Torulopsis glabrata was isolated in 10% of women with vulvovaginal candidiasis attending a vaginitis clinic. This infection was associated with recurrent vaginitis in almost one-third of case patients presenting with symptoms.
authors.affiliation: Clinica Ostetrico-Ginecologica, IRCCS Policlinico San Matteo, Università di Pavia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Spinillo
authors.forename: E
authors.initials: E
authors.lastname: Capuzzo
authors.forename: T O
authors.initials: TO
authors.lastname: Egbe
authors.forename: F
authors.initials: F
authors.lastname: Baltaro
authors.forename: S
authors.initials: S
authors.lastname: Nicola
authors.forename: G
authors.initials: G
authors.lastname: Piazzi
mesh_terms: D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000453:epidemiology*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012959:Socioeconomic Factors; D014627:Vaginitis / Q000453:epidemiology* / Q000382:microbiology