title: Limited responses of neuronal mRNAs to unilateral lesions of the rat entorhinal cortex.
abstract: Following unilateral electrolytic lesioning of the rat entorhinal cortex, we assessed changes in messenger RNA (mRNA) levels for four neuron-associated proteins, GAP-43, SCG10, 68 kDa neurofilament (NF68), and alpha 1-tubulin that encode proteins of importance to synaptic remodelling. The mRNA levels for GAP-43 and SCG10 were reduced in the septal nuclei, while those of SCG10 and alpha 1-tubulin were elevated in the hippocampus; at most, the changes ranged from -40% to +50% of controls. Changes in NF68 mRNA levels were not significant. Correlations were found between mRNA for SCG10 and both GAP-43 and NF68. In view of these modest changes in most mRNA levels examined, we suggest that post-translational regulation may also be important in responses to injury.
authors.affiliation: Department of Neurology, University of Southern California, School of Medicine, Los Angeles 90033, USA.
authors.forename: C
authors.initials: C
authors.lastname: Zarow
authors.forename: C E
authors.initials: CE
authors.lastname: Finch
mesh_terms: D000818:Animals; D018728:Entorhinal Cortex / Q000502:physiology*; D019922:GAP-43 Protein; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016900:Neurofilament Proteins / Q000378:metabolism; D009474:Neurons / Q000502:physiology; D017729:Presynaptic Terminals / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D014404:Tubulin / Q000378:metabolism
chemical_list: D019922:GAP-43 Protein; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; D012333:RNA, Messenger; D014404:Tubulin; C066858:neurofilament protein NF 68