title: [Non-Hodgkin's lymphomas associated with the acquired immunodeficiency syndrome. A multicenter clinical study of 77 cases].
abstract: BACKGROUND
  The aim of the present was to study the prevalence of non Hodgkin's lymphoma (NHL) in AIDS patients as well as the clinicopathologic characteristics, response to treatment and survival.
  
  
  METHODS
  From January 1984 to January 1991, 77 patients with NHL associated with AIDS diagnosed in 9 hospitals in Madrid were retrospectively studied.
  
  
  RESULTS
  Ninety-two per cent of the patients were men (mean age 30 years: range: 9-66 years), 62% were intravenous drug abusers and 20 (26%) homosexuals. Pathologic study determined that 62 (80%) patients had high grade NHL (44% small noncleaved), 17% immunoblastic and 20% unclassifiable, and 15 (20%) had intermediate grade (16% diffuse large cell) being all the cases of the B immunophenotype. Sixty-five per cent were in advanced stages and 69% had B symptoms. Extranodal localizations were present in 88%, bone marrow in 29% and CNS in 29%. Six cases had primary CNS lymphomas. 50% of the patients had less than 200 x 10(6)/l CD4 lymphocytes. Forty-seven patients were evaluable for response to chemotherapy: 12 (26%) showed a complete response 27 (57%) a partial response and 8 (17%) did not respond. Opportunistic infections developed in 18%. The estimated survival at 3 years was 14% (median 6 months). On univariate analysis the parameters related to the worst survival were: primary CNS lymphoma, liver involvement, lack of treatment response, LDH > or = 300 UI/l, alkaline phosphatase > or = 500 UI/l and ESR > or = 70 mm.
  
  
  CONCLUSIONS
  Non Hodgkin's lymphomas associated with AIDS usually behave in an "aggressive" way with a high frequency of advanced stages, B symptoms, high grade histologic subtypes and extranodal involvement. Response to treatment is poor, bone marrow toxicity frequent and survival short.
authors.affiliation: Grupo Cooperativo SIDA y Tumores de Madrid (Hospital 12 de Octubre).
authors.forename: R
authors.initials: R
authors.lastname: Rubio
authors.forename: F
authors.initials: F
authors.lastname: Pulido
authors.forename: V
authors.initials: V
authors.lastname: Pintado
authors.forename: J
authors.initials: J
authors.lastname: Díaz-Mediavilla
authors.forename: E
authors.initials: E
authors.lastname: Flores
authors.forename: M
authors.initials: M
authors.lastname: Serrano
authors.forename: J C
authors.initials: JC
authors.lastname: Alberdi
authors.forename: D
authors.initials: D
authors.lastname: López-Gay
authors.forename: J
authors.initials: J
authors.lastname: Verdejo
authors.forename: C
authors.initials: C
authors.lastname: Barros
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D015497:HIV-1; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D016019:Survival Analysis
vernacular_title: Linfomas no hodgkinianos asociados al síndrome de la inmunodeficiencia adquirida. Estudio clínico multicéntrico de 77 casos.