title: Isolation and characterization of fusaproliferin, a new toxic metabolite from Fusarium proliferatum.
abstract: A new toxic sesterterpene, named fusaproliferin, was purified from corn kernel cultures (120 mg/kg dry culture) of a strain of Fusarium proliferatum isolated from corn ear rot in northern Italy. The stain, designated ITEM-1494, also produced fumonisin B1 (1.500 mg/kg dry culture) and beauvericin (90 mg/kg dry culture), but not moniliformin. To monitor toxicity, the brine shrimp assay was used throughout the isolation procedure. Fusaproliferin had a molecular formula of C27H40O5, and it is the first sesterterpene isolated from a Fusarium species.
authors.affiliation: Dipartimento di Scienza degli Alimenti dell'Università degli Studi di Napoli, Federico II, Portici, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ritieni
authors.forename: V
authors.initials: V
authors.lastname: Fogliano
authors.forename: G
authors.initials: G
authors.lastname: Randazzo
authors.forename: A
authors.initials: A
authors.lastname: Scarallo
authors.forename: A
authors.initials: A
authors.lastname: Logrieco
authors.forename: A
authors.initials: A
authors.lastname: Moretti
authors.forename: L
authors.initials: L
authors.lastname: Mannina
authors.forename: A
authors.initials: A
authors.lastname: Bottalico
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification; D001156:Artemia / Q000502:physiology; D002274:Carcinogens, Environmental / Q000032:analysis / Q000302:isolation & purification; D003470:Culture Media; D003503:Cyclobutanes / Q000032:analysis / Q000302:isolation & purification; D047630:Depsipeptides; D037341:Fumonisins; D005670:Fusarium / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009183:Mycotoxins / Q000032:analysis / Q000302:isolation & purification*; D010455:Peptides; D013729:Terpenes / Q000032:analysis / Q000302:isolation & purification*; D003313:Zea mays
chemical_list: D000900:Anti-Bacterial Agents; D002274:Carcinogens, Environmental; D003470:Culture Media; D003503:Cyclobutanes; D047630:Depsipeptides; D037341:Fumonisins; D009183:Mycotoxins; D010455:Peptides; D013729:Terpenes; C093577:fusaproliferin; C004456:beauvericin; C008539:moniliformin; C056933:fumonisin B1