title: Synthesis and antihypertensive activity evaluation of indole derivatives N-acetamido substituted.
abstract: The synthesis of a series of 1-(alkyl- or aryl-aminocarbonylmethyl)-2-methyl- or 2-phenyl-indoles are described. All compounds were tested for antihypertensive activity on spontaneously hypertensive rats (SHR) and some of them showed a significant reduction of the arterial pressure.
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Grasso
authors.forename: C
authors.initials: C
authors.lastname: Molica
authors.forename: A M
authors.initials: AM
authors.lastname: Monforte
authors.forename: P
authors.initials: P
authors.lastname: Monforte
authors.forename: M
authors.initials: M
authors.lastname: Zappalà
authors.forename: M T
authors.initials: MT
authors.lastname: Monforte
authors.forename: A
authors.initials: A
authors.lastname: Trovato
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D011918:Rats, Inbred SHR; D013329:Structure-Activity Relationship
chemical_list: D000081:Acetamides; D000959:Antihypertensive Agents; D007211:Indoles