title: [Peroral vaccine therapy in dermatology].
abstract: In a group of 691 patients with different dermatoses the therapeutic effect of two forms of lyophilized vaccines administered orally according to a desensitization (drops) and immunization (tablets) plan. Their effect was as a rule marked already during the third week of treatment. During the final evaluation no signs of the disease were present or great improvement was recorded in 89-100% of the patients suffering from acne, chronic staphylococcal pyoderma or microbial eczema and 62% (drops) or 65% (tablets) of patients with atopic eczema. During treatment the authors did not observe with rare exceptions of focal reactions any undesirable effects. No significant differences were found between the two forms of the drugs as regards therapeutic effects. Contrary to antibiotics, which can cause remission of dermatosis, while early relapses cannot be prevented, oral vaccine treatment leads to long-term (extending over several years) favourable effects on the course of the disease. The immunization pattern used in tablet form vaccines is simpler, packing and storage is simpler, dosage is more accurate and more convenient for the patient.
authors.affiliation: Ustav lékarské mikrobiologie, Lékarská fakulta Univerzity Palackého, Olomouc.
authors.forename: D
authors.initials: D
authors.lastname: Koukalová
authors.forename: M
authors.initials: M
authors.lastname: Viktorinová
mesh_terms: D000152:Acne Vulgaris / Q000628:therapy; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use; D004485:Eczema / Q000382:microbiology / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D017192:Skin Diseases, Bacterial / Q000517:prevention & control / Q000628:therapy*; D013207:Staphylococcal Skin Infections / Q000628:therapy
chemical_list: D001428:Bacterial Vaccines
vernacular_title: Perorální vakcinoterapie v dermatologii.