title: Human and viral interleukin-10 in acute Epstein-Barr virus-induced infectious mononucleosis.
abstract: Human interleukin 10 (hIL-10), a product of monocytes, T cells, and B cells, shares extensive structural and functional similarity with viral IL-10 (vIL-10), a product of Epstein-Barr virus (EBV) replication. With two ELISAs, one that recognizes both hIL-10 and vIL-10 and the other specific for vIL-10, IL-10 was measured in serum or plasma and in saliva from 50 patients with acute EBV-induced infectious mononucleosis and from 19 normal subjects. In serum or plasma, 60% of the patients had measurable hIL-10 and/or vIL-10 and 18% had measurable vIL-10. In saliva, 20% of the patients had detectable hIL-10 and/or vIL-10 and none had detectable vIL-10. In contrast, hIL-10 and/or vIL-10 was undetectable in all 19 normal serum or plasma samples (P < .001 vs. patient samples). Among normal saliva samples, 21% had detectable hIL-10 and/or vIL-10 but none had detectable vIL-10. Thus, most patients with acute EBV-induced infectious mononucleosis transiently have abnormally high levels of circulating IL-10.
authors.affiliation: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA.
authors.forename: H
authors.initials: H
authors.lastname: Taga
authors.forename: K
authors.initials: K
authors.lastname: Taga
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Chretien
authors.forename: G
authors.initials: G
authors.lastname: Tosato
mesh_terms: D000208:Acute Disease; D000910:Antibodies, Heterophile / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology*; D016753:Interleukin-10 / Q000032:analysis* / Q000097:blood; D016555:Matched-Pair Analysis; D012463:Saliva / Q000737:chemistry; D014764:Viral Proteins / Q000032:analysis* / Q000097:blood
chemical_list: D000910:Antibodies, Heterophile; D000914:Antibodies, Viral; C066460:BCRF1 protein, Human herpesvirus 4; D014764:Viral Proteins; D016753:Interleukin-10