Relationship between insulin resistance and abnormal lipid profile in obese adolescents.
OBJECTIVE
To determine whether the lipid abnormalities observed in obese adolescents are associated with insulin resistance.


METHODS
We evaluated the relationship between lipid levels and insulin resistance in 82 obese adolescents. Insulin resistance was assessed by fasting insulin level and sum of the insulin values after an oral glucose tolerance test in all 82, and were compared with data from 40 nonobese adolescents. Whole-body glucose uptake during euglycemic hyperinsulinemia (M value) was performed in 19 of the obese adolescents and compared with that of 24 nonobese young adults.


RESULTS
The obese adolescents had significantly elevated low-density lipoprotein cholesterol (LDL-C) (3.09 +/- 0.73 mmol/L; 119 +/- 28.2 mg/dl) and triglycerides (1.22 +/- 0.62 mmol/L; 108 +/- 54.6 mg/dl) and low high-density lipoprotein cholesterol (HDL-C) levels (0.94 +/- 0.24 mmol/L; 36 +/- 9.1 mg/dl) when compared with values in the nonobese subjects. M values were significantly depressed in the obese compared with the nonobese subjects. Adiposity significantly correlated with low HDL-C and elevated triglyceride values. From the variables representing insulin resistance, the strongest correlation with the abnormal lipid profile was found for the M value. A stepwise multiple regression analysis revealed that the M value was the only step entered into the relationship for triglycerides and LDL-C, and both M value and fasting insulin were entered for HDL-C.


CONCLUSIONS
In obese adolescents the degree of insulin resistance explains a significant portion of the variance in the levels of triglycerides, LDL-C, and HDL-C.
Steinberger
J
J
Division of Pediatric Cardiology, University of Minnesota, Minneapolis, USA.
Moorehead
C
C
Katch
V
V
Rocchini
A P
AP
D000293:Adolescent; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood* / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood* / Q000187:drug effects; D005215:Fasting; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000493:pharmacokinetics*; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood*; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides