title: Is there a carryover effect of mild ovarian hyperstimulation with gonadotropins on the subsequent cycle?
abstract: OBJECTIVE
  To investigate the effect of mild ovarian hyperstimulation on hormonal and sonographic variables of the subsequent natural cycle.
  
  
  METHODS
  Prospective study of three consecutive cycles.
  
  
  METHODS
  University Hospital, Department of Reproductive Medicine, Division of Obstetrics and Gynecology.
  
  
  METHODS
  Twelve couples with subnormal semen as the only identifiable cause of subfertility.
  
  
  METHODS
  Subjects were offered IUI for three cycles. In the second cycle, mild ovarian hyperstimulation with 75 IU IM hMG was applied daily and ovulation was induced with 5,000 IU hCG. In the first and third both natural cycles, serum samples were obtained for hormone measurements and ultrasound (US) scanning of the ovaries was performed.
  
  
  METHODS
  To determine whether there was a carryover effect of mild ovarian hyperstimulation as applied in the second cycle, hormone levels and US scans of cycle 3 were compared with those of cycle 1.
  
  
  RESULTS
  None of the variables of cycle 3 were significantly different from those of cycle 1.
  
  
  CONCLUSIONS
  Because hormonal and sonographic variables in the subsequent natural cycle remain unchanged, a carryover effect of mild ovarian hyperstimulation with gonadotropins seems unlikely.
authors.affiliation: Department of Reproductive Medicine, University Hospital Utrecht, The Netherlands.
authors.forename: B J
authors.initials: BJ
authors.lastname: Cohlen
authors.forename: E R
authors.initials: ER
authors.lastname: te Velde
authors.forename: D
authors.initials: D
authors.lastname: Wissmann
authors.forename: R J
authors.initials: RJ
authors.lastname: van Kooij
authors.forename: P
authors.initials: P
authors.lastname: van Zonneveld
authors.forename: J D
authors.initials: JD
authors.lastname: Habbema
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008596:Menotropins / Q000008:administration & dosage / Q000627:therapeutic use*; D010053:Ovary / Q000502:physiology; D010062:Ovulation Induction; D011446:Prospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone