title: Convalescent pigs are protected completely against infection with a homologous Actinobacillus pleuropneumoniae strain but incompletely against a heterologous-serotype strain.
abstract: To study whether Actinobacillus pleuropneumoniae induces a species-specific immunity, we infected pigs in the left lung with serotype 3 or 9 and after 3 weeks we infected their right lungs with serotype 9. Convalescent pigs were protected against homologous strain reinfection, but after heterologous strain reinfection the degree of protection varied. Neutralizing antibodies were not essential for protection.
authors.affiliation: Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Cruijsen
authors.forename: L A
authors.initials: LA
authors.lastname: van Leengoed
authors.forename: M
authors.initials: M
authors.lastname: Ham-Hoffies
authors.forename: J H
authors.initials: JH
authors.lastname: Verheijden
mesh_terms: D000189:Actinobacillus Infections / Q000276:immunology* / Q000473:pathology; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D008168:Lung / Q000473:pathology; D009504:Neutrophils / Q000276:immunology; D013045:Species Specificity; D013552:Swine
chemical_list: D000907:Antibodies, Bacterial