[Genoprotective effect of drugs based on ecdysteroids in poisoning of rats with tetrachloromethane and chlorophos].
Molecular mechanisms of chromatin damage have been investigated during tetrachloromethane and chlorophos intoxication of experimental animals. Introduction of tetrachloromethane to experimental animals induced chromatin degradation causing a partial loss of histone H1-DNA fragmentation and formation of intermolecular bonds: DNA-protein. Intoxication with chlorophos results in repression of a part of genes due to augmented chromatin compactness. Preventive introduction of the steroid preparation from Serratula coronata L. to experimental animals exerts a genoprotective effect, probably, as a result of derepression of genes responsible for reparation of chromatin structure.
Chabannyĭ
V N
VN
Levitskiĭ
E L
EL
Gubskiĭ
Iu I
IuI
Kholodova
Iu D
IuD
Vistunova
I E
IE
Budmaska
M I
MI
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000235:genetics; D002843:Chromatin / Q000187:drug effects*; D004249:DNA Damage; D026461:Ecdysteroids; D008099:Liver / Q000187:drug effects*; D008297:Male; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000494:pharmacology*; D014236:Trichlorfon / Q000506:poisoning*
D002843:Chromatin; D026461:Ecdysteroids; D013256:Steroids; D014236:Trichlorfon
Genoprotektornyĭ éffekt preparatov na osnove ékdisteroidov pri otravlenii krys tetrakhlormetanom i khlorofosom.