title: Autoimmunity. Deletion of autoreactive B cells.
abstract: Several powerful mechanisms exist to prevent self-reactive B cells from maturing to secrete potentially destructive autoantibodies. These mechanisms act in addition to the removal of self-reactive helper T cells.
authors.affiliation: Department of Immunology, University of Birmingham Medical School, UK.
authors.forename: I C
authors.initials: IC
authors.lastname: MacLennan
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D017637:Clonal Deletion; D006801:Humans
chemical_list: D001323:Autoantibodies