title: Impact of combined large-scale ivermectin distribution and vector control on transmission of Onchocerca volvulus in the Niger basin, Guinea.
abstract: As part of the WHO Onchocerciasis Control Programme in West Africa (OCP), the attack phase of operations in the Niger basin in Guinea began in 1989 with the simultaneous use of ivermectin and vector control. Larvicide applications coupled with annual large-scale ivermectin distribution have greatly reduced blackfly infectivity (by 78.8% for the number of infective larvae per 1000 parous flies). The combination of vector control and ivermectin has permitted excellent control of transmission. In the original OCP area, it took 6-8 years of vector control alone to obtain an equivalent decrease in blackfly infectivity. For the same number of flies caught, transmission was much higher in areas where ivermectin had not been distributed. The combined use of ivermectin and vector control has opened up new prospects for carrying out OCP operations with, notably, the possibility of reducing larviciding operations.
authors.affiliation: Centre ORSTOM, Montpellier, France.
authors.forename: P
authors.initials: P
authors.lastname: Guillet
authors.forename: A
authors.initials: A
authors.lastname: Sékétéli
authors.forename: E S
authors.initials: ES
authors.lastname: Alley
authors.forename: H
authors.initials: H
authors.lastname: Agoua
authors.forename: B A
authors.initials: BA
authors.lastname: Boatin
authors.forename: Y
authors.initials: Y
authors.lastname: Bissan
authors.forename: L K
authors.initials: LK
authors.lastname: Akpoboua
authors.forename: D
authors.initials: D
authors.lastname: Quillévéré
authors.forename: E M
authors.initials: EM
authors.lastname: Samba
mesh_terms: D000818:Animals; D016701:Guinea / Q000453:epidemiology; D006801:Humans; D007300:Insect Control / Q000379:methods*; D007559:Ivermectin / Q000627:therapeutic use*; D017181:Onchocerca volvulus / Q000187:drug effects; D009855:Onchocerciasis / Q000517:prevention & control* / Q000635:transmission*; D010349:Patient Compliance; D015995:Prevalence; D012843:Simuliidae
chemical_list: D007559:Ivermectin