title: [Partial deficiency of 21-hydroxylase: a cause of hirsutism].
abstract: OBJECTIVE
  Presentation of two clinical cases of partial deficiency in hydroxylase 21 (PD in H21), examination of their clinical characteristics and discussion on the value of diagnostic hormonal determinations.
  
  
  METHODS
  Narón health centre, La Coruña.
  
  
  METHODS
  Two clinical cases who attended our centre in 1991 and 1992 because of the appearance of facial hair and facial acne, respectively.
  
  
  RESULTS
  Basal determinations of cortisol, dehydroepiandrosterone sulphate (DHEA-S), 4-androstendion (A), 17-hydroxyprogesterone (17-HP), free testosterone (T-1), LH and FSH were performed. The first four were then also determined after an injection of 0.25 mg of ACTH. According to the findings, the first case was a clear PD in H21, whereas the second was a light form of the disorder.
  
  
  CONCLUSIONS
  PD in H21 accounts for a considerable percentage of patients who attend because of hirsutism. For its diagnosis it is advisable to perform a stimulation test with ACTH and then obtain the 17-HP levels, along with the increment, 30 minutes after the injection. The levels should be triple that of the values for normal women.
authors.affiliation: Centro de Salud de Narón, La Coruña.
authors.forename: M
authors.initials: M
authors.lastname: Campos López-Carrión
authors.forename: J
authors.initials: J
authors.lastname: Caeiro Castelao
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital; D000324:Adrenocorticotropic Hormone; D000328:Adult; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006801:Humans
chemical_list: D000324:Adrenocorticotropic Hormone
vernacular_title: Deficiencia parcial de 21-hidroxilasa: una causa de hirsutismo.