DNA polymorphisms and haplotypes of human liver/bone/kidney alkaline phosphatase in Finns, Saamis and Swedes.
BclI and SstI restriction fragment length polymorphisms of human liver/bone/kidney or tissue-non-specific alkaline phosphatase were studied in population samples of Finns, Swedes and Swedish Saamis. No significant allele frequency differences were found between the three ethnic groups, but in comparison with a previously reported study of North American Caucasians, a highly significant difference was found with respect to BclI alleles. In contrast to previous findings, a significant linkage disequilibrium was found between BclI and SstI alleles.
Wennberg
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Department of Medical Genetics, University of Umeå, Sweden.
Sikström
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D000469:Alkaline Phosphatase / Q000235:genetics*; D000483:Alleles; D001842:Bone and Bones / Q000201:enzymology; D005387:Finland; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007668:Kidney / Q000201:enzymology; D015810:Linkage Disequilibrium; D008099:Liver / Q000201:enzymology; D012150:Polymorphism, Restriction Fragment Length; D013548:Sweden
D000469:Alkaline Phosphatase