Autoimmune thrombocytopenia: anti-glycoprotein IIb/IIIa auto antibodies are reduced after human anti-D immunoglobulin treatment.
In chronic autoimmune thrombocytopenic purpura (AITP), an indirect monoclonal antibody immobilised platelet antigen (MAIPA) assay detected serum glycoprotein (GP) IIb/IIIa antibodies in 16/39 (41%) cases. In patients with clinically active AITP, a direct MAIPA assay detected platelet-associated GP IIb/IIIa kantibodies in 8/13 (62%) cases. Platelet bound and serum antibody concentrations suggested a high antibody affinity for platelet membrane glycoprotein IIb/IIIa. Five AITP patients with platelet associated glycoprotein IIb/IIIa antibodies were treated with intravenous anti D immunoglobulin. All showed an increase in platelet counts and a decrease in platelet associated autoantibody. These responses could be due to immunosuppressive anti-idiotype antibodies in anti D immunoglobulin.
Boughton
B J
BJ
Department of Haematology, University of Birmingham Medical School Edgbaston, United Kingdom.
Cooke
R M
RM
Smith
N A
NA
Simpson
A W
AW
D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000628:therapy*; D006801:Humans; D007118:Immunoassay; D010980:Platelet Membrane Glycoproteins / Q000276:immunology*; D018029:Rho(D) Immune Globulin / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000097:blood / Q000276:immunology* / Q000628:therapy*
D001323:Autoantibodies; D010980:Platelet Membrane Glycoproteins; D018029:Rho(D) Immune Globulin