title: Lanosterol and 27-norlanosterol oligosaccharides from the bulbs of Chionodoxa gigantea.
abstract: New lanosterol and 27-norlanosterol oligosaccharides were found in the bulbs of Chionodoxa gigantea. Their structures were established mainly by extensive 2D NMR analysis as well as by comparison with spectral data of known compounds. The inhibition of cyclic AMP phosphodiesterase by the lanosterol derivatives was assayed as the primary screening test to find new medicinal materials.
authors.affiliation: Tokyo College of Pharmacy, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mimaki
authors.forename: S
authors.initials: S
authors.lastname: Kubo
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Sashida
authors.forename: L G
authors.initials: LG
authors.lastname: Song
authors.forename: T
authors.initials: T
authors.lastname: Nikaido
authors.forename: T
authors.initials: T
authors.lastname: Ohmoto
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D002240:Carbohydrate Sequence; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*
chemical_list: D009844:Oligosaccharides; D007810:Lanosterol; D015105:3',5'-Cyclic-AMP Phosphodiesterases