title: Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma.
abstract: Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper. Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.
authors.affiliation: Cattedra di Anatomia e Istologia Patologica, Università degli Studi di Milano, IRCCS H. San Raffaele, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.forename: L
authors.initials: L
authors.lastname: De Santis
authors.forename: F
authors.initials: F
authors.lastname: Mangili
authors.forename: I
authors.initials: I
authors.lastname: Sassi
authors.forename: S
authors.initials: S
authors.lastname: Luchini
authors.forename: C
authors.initials: C
authors.lastname: Mandelli
authors.forename: G
authors.initials: G
authors.lastname: Santambrogio
authors.forename: A
authors.initials: A
authors.lastname: Cantaboni
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000235:genetics / Q000401:mortality; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000032:analysis*; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000401:mortality; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
chemical_list: D004273:DNA, Neoplasm; D018719:Erb-b2 Receptor Tyrosine Kinases