title: [Regulation of parathyroid hormone in molecular biological aspect].
abstract: The synthesis of human parathyroid hormon (PTH) is controlled by extracellular Ca2+ concentration and 1,25 (OH)2D3, independently, nCaRE (negative calcium responsive element) and nVDRE (negative vitamin D responsive element) have been detected on 5' flanking region of human PTH gene. And also gene mutations of PTH in hereditary hypoparathyroidism was discovered in hereditary hypoparathyroidism.
authors.affiliation: Department of Pediatrics, Okayama University Medical School.
authors.forename: H
authors.initials: H
authors.lastname: Tokumaru
authors.forename: Y
authors.initials: Y
authors.lastname: Seino
mesh_terms: D000818:Animals; D001483:Base Sequence; D002117:Calcitriol / Q000502:physiology; D002118:Calcium / Q000502:physiology; D006801:Humans; D007011:Hypoparathyroidism / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D010280:Parathyroid Glands / Q000378:metabolism; D010281:Parathyroid Hormone / Q000096:biosynthesis* / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D010281:Parathyroid Hormone; D002117:Calcitriol; D002118:Calcium