title: [Effect of morphological changes on perfusion and metabolism in cerebral microangiopathy. A comparison of PET, SPECT, and magnetic resonance imaging findings].
abstract: 51 patients with cerebral microangiopathy were studied with MRI, 18FDG-PET, and 99mTc-HMPAO-SPECT. Exact morphological correlation of MRI-findings to functional data from PET and SPECT was obtained by a special head holder system applied to the patient's head. Patients with less than four lacunar infarctions (LI) and without or only slight deep white matter lesions (DWML) in MRI showed no significantly changed parameters (rMRGlu, rCBF) compared to patients with four or more LI and severe DWML. Patients with medium to severe outer and inner brain atrophy showed significantly lower rMRGlu and rCBF values in both cortex and white matter than patients with no to only slight atrophy. Thus, in patients with cerebral microangiopathy only atrophy and not the presence of LI and DWML is associated with a significant reduction of rCBF and rMRGlu.
authors.affiliation: Klinik für Nuklearmedizin, RWTH Aachen, FRG.
authors.forename: O
authors.initials: O
authors.lastname: Sabri
authors.forename: D
authors.initials: D
authors.lastname: Hellwig
authors.forename: H J
authors.initials: HJ
authors.lastname: Kaiser
authors.forename: C
authors.initials: C
authors.lastname: Doherty
authors.forename: R
authors.initials: R
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Mull
authors.forename: K W
authors.initials: KW
authors.lastname: Willmes von Hinckeldey
authors.forename: U
authors.initials: U
authors.lastname: Büll
authors.forename: A
authors.initials: A
authors.lastname: Thron
authors.forename: E B
authors.initials: EB
authors.lastname: Ringelstein
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D005462:Fluorine Radioisotopes / Q000627:therapeutic use; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D009928:Organ Specificity; D015609:Organotechnetium Compounds; D010091:Oximes; D010477:Perfusion; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005462:Fluorine Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D019788:Fluorodeoxyglucose F18; D019690:Technetium Tc 99m Exametazime; D003847:Deoxyglucose
vernacular_title: Einfluss morphologischer Veränderungen auf Durchblutung und Stoffwechsel bei zerebraler Mikroangiopathie. Ein Vergleich von PET-, SPECT- und Kernspintomographie-Befunden.