[Effect of pharmacological stimulation and blockade of alpha-adrenergic receptors on adrenocorticotropic hormone and cortisol in the blood of people of various age].
Age-associated peculiarities of the pituitary-adrenal system reactions to alpha 1-adrenergic preparations were studied in 60 normal adult, elderly and old subjects. Concentrations of ACTH and cortisol in blood were determined by the radioimmune method before and 2 hours after prazosin was given or 20 and 60 min. after intake of phenylephrine hydrochloride. The activation of alpha 1-adrenergic receptors (phenylephrine) caused an increase in the blood concentrations of ACTH and cortisol, whereas the blockade of alpha 1-adrenergic receptors (prazosin) induced an essential decrease in the concentrations of these hormones in blood of the persons investigated at various age. In persons of higher-age groups phenylephrine caused a higher activation of the pituitary-adrenal system.
Shatylo
V B
VB
Fedirko
M I
MI
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000187:drug effects*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000378:metabolism; D011224:Prazosin / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D011224:Prazosin
Vplyv farmakolohichnoĭ stymyliatsiĭ ta blokady alpha-adrenoretseptoriv na contsentratsiiu AKTH i kortyzolu v krovi liudeĭ riznogo viku.