title: Developing glucose sensors for in vivo use.
abstract: The potential uses for in vivo glucose sensors in patients with diabetes mellitus include an alarm for low blood-glucose concentrations, a continuous read-out of glucose levels and as part of a feedback-controlled insulin delivery system (artificial pancreas). Most experience has been with implanted amperometric enzyme electrodes, though sensors based on field-effect transistors (FETs) show promise for the future. Sensing responses at the subcutaneous site correlate with plasma-glucose values, but there are often problems of calibration and drift. Implantable glucose sensors are not therefore in routine clinical use. Non-invasive glucose sensing based on near-infrared spectroscopy is being actively investigated as an alternative strategy.
authors.affiliation: Division of Chemical Pathology, United Medical and Dental Schools, Guy's Hospital, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Pickup
mesh_terms: D015374:Biosensing Techniques; D001709:Biotechnology; D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood; D005069:Evaluation Studies as Topic; D006801:Humans; D008991:Monitoring, Physiologic; D019736:Prostheses and Implants
chemical_list: D001786:Blood Glucose