[Antiviral activity of the natural immunostimulant "Vegetan" in murine herpetic meningoencephalitis, guinea pig genital herpes, and canine parvoviral enteritis].
Antiviral activity of vegetan, a new natural immunostimulator, in herpetic meningoencephalitis of mice, genital herpes of guinea pigs, and parvoviral enteritis of dogs was compared to that of acylguanosine and phosphonoformic acid (PFA). Vegetan incorporated in liposomes or pure was the most active if used for prevention 5 days before intracerebral infection of mice with herpes simplex type 1 virus, whatever the dose of infective agent (10 to 100 LD50). Protective efficacy of vegetan was 57-63%, whereas for ara-A, acylguanosine, and PFA these values were, respectively, 20, 25, and 33%. Use of liposomal vegetan preparation ensured a 80% protective effect. Vegetan had a manifest antiviral effect in guinea pigs with genital herpes and in dogs with parvoviral enteritis.
L'vov
N D
ND
Chekanovskaia
L A
LA
Alimbarova
L M
LM
Mel'nikov
V R
VR
Zontov
S V
SV
Slepushkin
V A
VA
Barinskiĭ
I F
IF
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D002522:Chlorocebus aethiops; D004285:Dogs; D004751:Enteritis / Q000188:drug therapy; D006168:Guinea Pigs; D006566:Herpesviridae Infections / Q000188:drug therapy*; D008590:Meningoencephalitis / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D009930:Organic Chemicals; D010322:Parvoviridae Infections / Q000188:drug therapy*; D014709:Vero Cells
D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D009930:Organic Chemicals; C050184:vegetan
Antivirusnaia aktivnost' prirodnogo immunostimuliatora "Vegetan" pri gerpeticheskom meningoéntsefalite mysheĭ, genital'nom gerpes morskikh svinok i parvovirusnom énterite sobak.