[Factors regulating parathyroid hormone and the mechanism of signal transduction].
The secretion of parathyroid hormone (PTH) is influenced by various factors, but extracellular calcium concentration ([Ca2+]e) is the sole factor established to be the physiological regulator. [Ca2+]e acts on Ca2+ sensing receptor recently cloned, and elevates intracellular calcium ([Ca2+]i) and inositol trisphosphate. Although the changes in cAMP level and C-kinase activity also have been demonstrated, the mediator directly operating secretory mechanism of PTH has not been defined. Recently, the activity of chromogranin A-related peptides to modulate PTH secretion was found and their role as the autocrine-paracrine regulator of PTH secretion has been proposed.
Nagata
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Third Department of Internal Medicine, National Defense Medical College.
D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D053379:Chromogranin A; D002864:Chromogranins / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction
D053379:Chromogranin A; D002864:Chromogranins; D010281:Parathyroid Hormone; D011956:Receptors, Cell Surface; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D002118:Calcium