title: An antimicrobial abietane from the root of Plectranthus hereroensis.
abstract: A new abietane diterpene, 16-acetoxy-7 alpha, 12-dihydroxy-8,12-abietadiene-11,14-dione, has been isolated from the acetone extract of the root of Plectranthus hereroensis and its structure established by spectroscopic means. This compound showed antibacterial activity against Staphylococcus aureus and Vibrio cholerae, and antiviral activity against Herpes simplex type II.
authors.affiliation: Faculdade de Farmácia, CECF, Universidade de Lisboa, Portugal.
authors.forename: O
authors.initials: O
authors.lastname: Batista
authors.forename: M F
authors.initials: MF
authors.lastname: Simões
authors.forename: A
authors.initials: A
authors.lastname: Duarte
authors.forename: M L
authors.initials: ML
authors.lastname: Valdeira
authors.forename: M C
authors.initials: MC
authors.lastname: de la Torre
authors.forename: B
authors.initials: B
authors.lastname: Rodríguez
mesh_terms: D045784:Abietanes; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009904:Optical Rotation; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012639:Seeds; D018139:Simplexvirus / Q000187:drug effects*; D013055:Spectrophotometry, Infrared
chemical_list: C093056:16-acetoxy-7,12-dihydroxy-8,12-abietadiene-11,14-dione; D045784:Abietanes; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D010616:Phenanthrenes; D011809:Quinones