Liquid chromatographic assay of diatrizoic acid and its diiodo degradation products in radio-opaque solutions.
A liquid chromatographic method is described for the analysis of diatrizoic acid (2,4,6-triiodo-3,5-diacetamidobenzoic acid) and its 2,4- and 2,6-diiodo degradation products in radio-opaque injection solutions. The method is accurate, precise, and linear at a concentration range of 5-50 ppm.
Farag
S A
SA
U.S. Food and Drug Administration, Division of Drug Analysis, St. Louis, MO 63101, USA.
D002853:Chromatography, Liquid / Q000379:methods*; D003287:Contrast Media / Q000737:chemistry*; D003973:Diatrizoate / Q000032:analysis* / Q000378:metabolism; D015203:Reproducibility of Results
D003287:Contrast Media; D003973:Diatrizoate