title: [T-cell rich B-cell lymphoma: diagnosis, differential diagnosis, and classification of two representative cases].
abstract: Two post mortem examinations from the Institute of Pathology, Albert-Ludwigs-University of Freiburg, will be presented. In both cases diagnosis of a T-cell-rich B-cell-lymphoma was first established after necropsy and evaluation of the immunohistochemical results. In the first case a peripheral T-cell-lymphoma was diagnosed after a peripheral T-cell-marker test. A liver biopsy showed suspicion of a Hodgkin-lymphoma. In the second case a biopsy of an extended retroperitoneal tumor showed a centroblastic non-Hodgkin-lymphoma 3 weeks before death. By autopsy we found in both cases a wide infiltration with small monomorphic lymphocytes. Less than 20% of the infiltrate consisted of polymorphous blasts with a wide morphologic range and prominent nucleoli. Immunohistochemistry showed the blasts to be CD20-positive, while the small monomorphic lymphocytes expressed the CD3 marker. In the first case kappa-light-chain-restriction was shown in the blasts by immunohistochemistry. Differential diagnosis difficulties, diagnostic criteria, prognosis and classification of these cases in the common non-Hodgkin-lymphoma classification will be discussed in view of the current literature.
authors.affiliation: Pathologisches Institut, Universität Freiburg.
authors.forename: B
authors.initials: B
authors.lastname: Wolfarth
authors.forename: A
authors.initials: A
authors.lastname: Jeron
authors.forename: E W
authors.initials: EW
authors.lastname: Herbst
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology
vernacular_title: T-Zell-reiches B-Zell-Lymphom: Diagnose, Differentialdiagnose und Klassifikation anhand von zwei Fallbeispielen.