Effects of 5-HT3 receptor antagonists on models of acute and delayed emesis induced by cisplatin in the ferret.
The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was investigated in the ferret over a 72 and 24 hr period respectively. The 5-HT3 receptor antagonists ondansetron and alosetron markedly antagonized or abolished the emesis during the "acute phase" and, whilst antagonizing the emesis during the delayed phase, also revealed a 5-HT3 receptor antagonist resistant component. These cisplatin paradigms may provide models relevant to the study of acute and delayed emesis induced by cisplatin in man.
Rudd
J A
JA
School of Pharmacy, University of Bradford, U.K.
Naylor
R J
RJ
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004195:Disease Models, Animal; D004639:Emetics / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005289:Ferrets; D017294:Ondansetron / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D002243:Carbolines; D004639:Emetics; D012702:Serotonin Antagonists; C090840:alosetron; D017294:Ondansetron; D002945:Cisplatin