title: The effects of 5-HT3 receptor antagonists in models of dependency and withdrawal.
abstract: Pharmacological manipulations to enhance 5-HT synthesis and release have been reported to reduce alcohol intake. However, recent evidence indicates that 5-HT3 receptor antagonists may also exert a similar effect in a number of species. This report reviews the existing data which implicates a central role for 5-HT3 receptors in the control of psychoactive substance abuse.
authors.affiliation: School of Pharmacy, University of Bradford, West Yorkshire, U.K.
authors.forename: B
authors.initials: B
authors.lastname: Costall
authors.forename: A M
authors.initials: AM
authors.lastname: Domeney
authors.forename: M E
authors.initials: ME
authors.lastname: Kelly
authors.forename: R J
authors.initials: RJ
authors.lastname: Naylor
mesh_terms: D000428:Alcohol Drinking / Q000188:drug therapy; D000437:Alcoholism / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
chemical_list: D012702:Serotonin Antagonists; D000431:Ethanol