title: MR appearance of cerebral cortex in children with and without a history of perinatal anoxia: preliminary observations.
abstract: OBJECTIVE
  The purpose of this study was to characterize the MR signal intensity of the cerebral cortex in children and to determine if the cortex is abnormal on MR images of patients with anoxia at birth (defined as persistent O2 saturation of less than 80% and requiring intubation or assisted ventilation for more than 24 hr).
  
  
  METHODS
  MR imaging was done in 10 patients with no history of anoxia and in nine patients with a history of anoxia. The T2 and T1 signals from the central gyri, the pre- and postcentral gyri, and the calcarine and insular regions of the gray matter were visually graded according to their intensity and to the degree that the low and high signal intensity each involved the entire length of that region.
  
  
  RESULTS
  Low T2-signal intensity from the central gyri, the pre- and postcentral gyri, and the calcarine and insular regions of the gray matter was present on MR images made in patients without a history of anoxia and was absent in patients with a history of anoxia. High T1-signal intensity was seen in the central gyri in patients without a history of anoxia. Patients aged 1 year or older with a history of anoxia had no MR signal differences in any gray-matter region on either T1- or T2-weighted images.
  
  
  CONCLUSIONS
  Low T2-signal intensity was seen in the central gyri, the pre- and postcentral gyri, and the calcarine and insular regions of the gray matter on MR images of patients with no history of anoxia but was not seen in those with a history of anoxia. Loss of the normal cortical T2 hypointensity may aid in establishing the diagnosis of anoxic brain injury.
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill 27599-7510, USA.
authors.forename: M
authors.initials: M
authors.lastname: Castillo
authors.forename: J K
authors.initials: JK
authors.lastname: Smith
authors.forename: S K
authors.initials: SK
authors.lastname: Mukherji
mesh_terms: D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000473:pathology*; D002675:Child, Preschool; D006801:Humans; D002534:Hypoxia, Brain / Q000151:congenital / Q000175:diagnosis*; D007223:Infant; D007231:Infant, Newborn