Flunitrazepam for sleep disturbance in children with intractable epilepsy.
Add-on therapy with flunitrazepam (FNZ) was performed in 5 children with marked sleep disturbance and intractable seizures. Correction of the sleep disturbance was attained immediately after the start of FNZ administration in all patients. Furthermore, a significant decrease in the seizure frequency (3 patients) and improved quality of life (4 patients) were concomitantly observed. There was no adverse effect or interaction with conventional AEDs on long-term use.
Konishi
T
T
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Masuko
K
K
Naganuma
Y
Y
Hongou
K
K
Yagi
S
S
D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications*; D005445:Flunitrazepam / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology
D005445:Flunitrazepam