Potential approaches for myocardial regeneration.
Cardiomyocytes in the adult mammal retain little or none of their developmental capacity for hyperplastic growth. As a consequence of this differentiated, nonproliferative phenotype, cardiomyocyte loss due to injury or disease is irreversible. Therapeutic intervention in end-stage diseased hearts is currently limited to cardiac transplantation. An increase in cardiomyocyte number in diseased hearts could improve function. Augmentation of the cardiomyocyte population may be achievable by the expression of regulatory proteins in the myocardium, or by intracardiac grafting of exogenous cardiomyocytes.
Soonpaa
M H
MH
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis 46202-4800, USA.
Daud
A I
AI
Koh
G Y
GY
Klug
M G
MG
Kim
K K
KK
Wang
H
H
Field
L J
LJ
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D015870:Gene Expression; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000628:therapy; D006801:Humans; D006965:Hyperplasia; D008322:Mammals; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D012038:Regeneration