Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q.
Eight new loci have been assigned to sheep Chromosome (Chr) 1q by use of a chromosomally characterized minipanel of sheep x hamster cell hybrids. Four loci, which have been mapped to the distal region of human Chr 3q, are ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1). The other four loci, on human Chr 21, include interferon alpha receptor (IFNAR); interferon inducible protein p78, murine (MX1); collagen type VI, alpha 1 (COL6A1); and S100 protein, beta polypeptide (S100B). All of these loci, except GLUT2 and MX1, have been mapped onto bovine Chr 1 or are syntenic with loci on this chromosome. The in situ localization of transferrin (TF) to sheep Chr 1q42-q45 confirms our previous assignment of this locus and independently anchors the eight new syntenic loci to sheep Chr 1q.
Broad
T E
TE
Gene Mapping Unit, AgResearch Grasslands Research Centre, Palmerston North, New Zealand.
Burkin
D J
DJ
Cambridge
L M
LM
Lewis
P E
PE
Maher
D W
DW
Ansari
H A
HA
Pearce
P D
PD
Jones
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C
D000818:Animals; D002417:Cattle; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D002893:Chromosomes, Human, Pair 3; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D011506:Proteins / Q000235:genetics; D012756:Sheep / Q000235:genetics*; D014168:Transferrin / Q000235:genetics
D011506:Proteins; D014168:Transferrin