Structure-activity relationships of synthetic digitoxigenyl glycosides.
Antiviral, cytotoxic and anti-ATPase activities of 14 synthetic digitoxigenyl glycosides were compared with each other. The activities of those containing gentiobioside and melibioside were much weaker than the others. On the other hand, the three activities were highly correlated with each other.
Takechi
M
M
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.
Tanaka
Y
Y
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D002240:Carbohydrate Sequence; D004071:Digitalis Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D004073:Digitoxigenin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D006564:Herpesviridae / Q000187:drug effects; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D004071:Digitalis Glycosides; D006027:Glycosides; D004073:Digitoxigenin; D000251:Adenosine Triphosphatases