title: Glial responses to hypoxic/ischemic encephalopathy in neonatal rat cerebrum.
abstract: This study was undertaken to examine glial responses in the immature rat brain to hypoxic/ischemic injury. The results indicate that developing microglia are the first and principle glial element that responds to hypoxic/ischemic injury during the neonatal period. The astrocyte response occurs later and macrophage infiltration may be delayed or absent.
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohno
authors.forename: H
authors.initials: H
authors.lastname: Aotani
authors.forename: M
authors.initials: M
authors.lastname: Shimada
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000276:immunology / Q000502:physiology*; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000276:immunology; D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007511:Ischemia / Q000473:pathology*; D017628:Microglia / Q000276:immunology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley