title: Recombinant vaccine development: a novel approach to ectoparasite control. A review of development of a recombinant vaccine for hypodermosis based on hypodermin A.
abstract: Cattle grubs (Hypoderma lineatum and H. bovis) are obligate parasites of cattle for most of their one year life cycle. Previously exposed animals become resistant to productive reinfestation, presumably as a result of immune system involvement, suggesting potential control by vaccination. Research progress towards development and utilization of a recombinant subunit vaccine for hypodermosis is described.
authors.affiliation: Knipling-Bushland U.S. Livestock Insects Research Laboratory, U.S. Department of Agriculture, Kerrville, TX 78028-9184.
authors.forename: K B
authors.initials: KB
authors.lastname: Temeyer
authors.forename: J H
authors.initials: JH
authors.lastname: Pruett
authors.forename: I
authors.initials: I
authors.lastname: Kuhn
authors.forename: J
authors.initials: J
authors.lastname: Files
mesh_terms: D000818:Animals; D001709:Biotechnology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D004175:Diptera / Q000201:enzymology / Q000276:immunology*; D007000:Hypodermyiasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology; D012697:Serine Endopeptidases / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000302:isolation & purification*
chemical_list: D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic; D012697:Serine Endopeptidases; C030092:hypodermin