title: The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action.
abstract: Both the observed cis-inhibition and the proposed trans-activation of the insulin receptor tyrosine kinase help explain insulin signalling through its receptor.
authors.affiliation: Department of Crystallography, Birkbeck College, London, UK.
authors.forename: N Q
authors.initials: NQ
authors.lastname: McDonald
authors.forename: J
authors.initials: J
authors.lastname: Murray-Rust
authors.forename: T L
authors.initials: TL
authors.lastname: Blundell
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008958:Models, Molecular; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011972:Receptor, Insulin / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology
chemical_list: D007328:Insulin; D011972:Receptor, Insulin