Predictive value of fetal serum beta 2-microglobulin for neonatal renal function.
When fetal urinary-tract malformations (UTM) are discovered, management is based on the prediction of postnatal renal function, currently made by fetal urinary biochemistry and sonography. Serum beta 2-microglobulin has been used postnatally to estimate renal function and does not cross the placenta. We investigated the relation between fetal serum beta 2-microglobulin and renal function by comparing 64 unaffected fetuses and 15 fetuses with UTM. A beta 2-microglobulin above a 5.6 mg/L cut-off gave cross-validated sensitivity of 80.0%, specificity of 98.6%, a positive predictive value of 88.9%, and a negative predictive value of 97.1% for our cohort study.
Berry
S M
SM
Division of Maternal Fetal Medicine, Wayne State University, Detroit, Michigan, USA.
Lecolier
B
B
Smith
R S
RS
Bercau
G
G
Dombrowski
M P
MP
Puder
K S
KS
Kithier
K
K
Bidat
L
L
Johnson
M P
MP
Cotton
D B
DB
D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000502:physiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D014551:Urinary Tract / Q000002:abnormalities / Q000196:embryology; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin