[Control of wound healing from connective tissue aspect].
The recovery from trauma is a function of life and survival of the organicism. Tissue injury resulting in irreversible cell death and connective tissue disruption initiates the repair process. Wounds heal by scarring where a new cell population resides in a newly deposited connective tissue matrix. The chemical composition of a scar is similar to normal dermis, but its organization differs from dermis. The ineptitude to reassemble collagen into normal dermal patterns specifics a scar. A scar patches a defect and in most cases normal function is restored. However with impaired scarring wound dehiscence occurs and the over production and deposition of unstable scar also causes a catastrophic end point. Besides the volume of scar tissue deposited, the organization of that tissue is important for determining the scar's integrity, stability and restoration of function. The maturation of scar dependents upon the character of the resident cell populations, quality of deposited connective tissue and the interactions between those components. Here our focus will be on the regulation of wound healing in terms of collagen fibers reorganization. As our knowledge of cell-cell and cell-matrix interactions in the repair process grows, the better the wound care offered to the patient in the future. The goal is to instigate and maintain a healing process where the pattern of deposited collagen fibers resembles that of dermis.
Ehrlich
H P
HP
Abteilungen für Chirurgie und Biochemie, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, USA.
D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000503:physiopathology*; D003094:Collagen / Q000502:physiology* / Q000648:ultrastructure; D003238:Connective Tissue / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D051381:Rats; D013529:Surgical Wound Dehiscence / Q000473:pathology / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*
D003094:Collagen
Regulation der Wundheilung aus der Sicht des Bindegewebes.