Yeast systems for the expression of heterologous gene products.
Significant advances have been made over the past year in our understanding of some of the critical parameters affecting high-level production of heterologous proteins in yeast. Recent studies of plasmid stability, promoter strength and secretion efficiency are yielding potential improvements in expression.
Buckholz
R G
RG
Biotechnology Department, Glaxo Research Institute, Research Triangle Park, North Carolina 27709.
D001709:Biotechnology; D004274:DNA, Recombinant / Q000235:genetics; D015870:Gene Expression; D006031:Glycosylation; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics*; D015003:Yeasts / Q000235:genetics* / Q000378:metabolism
D004274:DNA, Recombinant; D011994:Recombinant Proteins