title: Microtubules and microtubule-associated proteins.
abstract: Microtubule research is becoming increasingly diverse, reflecting the many isoforms and modifications of tubulin and the many proteins with which microtubules interact. Recent advances are particularly visible in four areas: microtubule motor proteins (their structures, stepping modes, and forces); microtubule nucleation (the roles of centrosomes and gamma-tubulin); tubulin folding (mediated by cytoplasmic chaperones); and the expanding list of microtubule-associated proteins, knowledge of their phosphorylation states, and information on their effects on microtubule dynamics.
authors.affiliation: Max Planck Unit for Structural Molecular Biology, Hamburg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Mandelkow
authors.forename: E M
authors.initials: EM
authors.lastname: Mandelkow
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology; D018385:Centrosome / Q000737:chemistry; D008869:Microtubule-Associated Proteins / Q000737:chemistry*; D008870:Microtubules / Q000648:ultrastructure*; D018832:Molecular Chaperones / Q000737:chemistry; D012689:Sequence Homology, Nucleic Acid; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism; D016875:tau Proteins / Q000502:physiology
chemical_list: D008869:Microtubule-Associated Proteins; D018832:Molecular Chaperones; D014404:Tubulin; D016875:tau Proteins