An age-related correlation between levels of beta-amyloid precursor protein and beta-amyloid in human cerebrospinal fluid.
We investigated the levels of amyloid precursor protein (APP) and beta-amyloid peptide (A beta) in the cerebrospinal fluid (CSF) from 110 individuals ranging in age from newborn to 82-years old to analyze their regulation with age. These samples were segregated into two groups; one group contained CSF samples from patients with diagnosed CNS abnormalities and the second group contained CSF samples from patients with no known CNS disorders. The presence of APP and A beta was detected in all ages and from both CSF groups. No significant difference in the average level of A beta or APP was noted from either group with a change in age. However, a positive correlation was found to exist between levels of APP and A beta in individuals 25 years and older, suggesting that APP and A beta processing in the CSF is developmentally regulated. This observation was observed for both CSF groups.
Carroll
R T
RT
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48106, USA.
Lust
M R
MR
Kim
K S
KS
Doyle
P D
PD
Emmerling
M R
MR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D016564:Amyloid beta-Protein Precursor / Q000134:cerebrospinal fluid*; D015153:Blotting, Western; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor