[Effect of yishen jianpi drugs on T lymphocyte subsets, soluble interleukin-2 receptor and red blood cell immunity of senile deficiency syndrome patients].
To evaluate the effect of Yishen Jianpi drugs (YJD) on immunological function of the Senile Deficiency Syndrome (SDS) patients, T lymphocyte subsets, soluble interleukin-2 receptor (SIL-2 R), the red blood cell immunity, the rate of red blood cell C 3b receptor rosette (RBC-C 3 bRR) and red blood cell immune complex rosette (RBC-ICR) were dynamically investigated in 31 SDS patients as well as in normal controls.


RESULTS
the percentage of CD3, CD4 and CD4/CD8 ratio and the rate of RBC-C 3 bRR in SDS were all significantly lower than that of control (P < 0.01). The further analysis also revealed that between the immunological indices of CD4/CD8 ratio and SIL-2 R in SDS patients were markedly negative correlated (r = -0.572, P < 0.01) while positive correlated (r = 0.435, P < 0.02) markedly between CD4/CD8 and RBC-C 3 bRR. After treatment with YJD, in comparing pretreatmentally, all the above-mentioned immunological indices, following the relief of clinical manifestation of SDS, they were corresponding negatively changed, and there were marked significance (P < 0.01) except red blood cell immunity. It suggested that YJD would markedly improve and/or regulate immunological function in SDS.
Fan
G R
GR
Affiliated Subei Peoples Hospital, Yangzhou Medical College, Jiangsu.
Zong
W J
WJ
Wang
X L
XL
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects* / Q000276:immunology; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D017463:Receptors, Complement 3b / Q000187:drug effects / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000187:drug effects* / Q000378:metabolism; D013158:Splenic Diseases / Q000188:drug therapy / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D016711:Yang Deficiency / Q000188:drug therapy / Q000276:immunology; D016710:Yin Deficiency / Q000188:drug therapy / Q000276:immunology
D004365:Drugs, Chinese Herbal; D017463:Receptors, Complement 3b; D015375:Receptors, Interleukin-2