title: Isolation and physico-chemical characterization of an antifungal and antibacterial peptide produced by Bacillus licheniformis A12.
abstract: An antifungal substance named peptide A12-C has been purified to homogeneity from supernatants of sporulated cultures of Bacillus licheniformis A12. It consists of a 0.77-kDa hydrophilic peptide containing two residues of Glu and one of Arg, Ala, Pro, Tyr and Orn. No fatty acids, phosphorus or carbohydrates have been detected. Peptide A12-C is active on several fungi (Microsporum canis CECT 2797, Mucor mucedo CECT 2653, M. plumbeus (CCM F 443, Sporothrix schenckii CECT 2799 and Trichophyton mentagrophytes CECT 2793) and bacteria (Bacillus megaterium, Corynebacterium glutamicum, Sarcina and Mycobacterium), although the latter are less sensitive.
authors.affiliation: Department of Microbiology, Faculty of Sciences, University of Granada, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gálvez
authors.forename: M
authors.initials: M
authors.lastname: Maqueda
authors.forename: M
authors.initials: M
authors.lastname: Martínez-Bueno
authors.forename: M
authors.initials: M
authors.lastname: Lebbadi
authors.forename: E
authors.initials: E
authors.lastname: Valdivia
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D001709:Biotechnology; D005658:Fungi / Q000187:drug effects; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010455:Peptides