Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor. II.
To search for possible anti-tumor-promoters, we carried out a primary screening of twenty-four 29-nor-cucurbitacin glucosides isolated from the roots of Cayaponia tayuya (Cucurbitaceae) using an in vitro synergistic assay system. Of these glucosides, cayaponosides B (5), B3 (7), D (8), D3b (22) and C2 (23) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, 5 and 23 exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan.
Takasaki
M
M
Kozuka
M
M
Nagao
T
T
Okabe
H
H
Irino
N
N
Nakasumi
T
T
Tokuda
H
H
Nishino
H
H
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014775:Virus Activation / Q000187:drug effects*
D014315:Triterpenes