title: Bilateral spastic cerebral palsy--MRI pathology and origin. Analysis from a representative series of 56 cases.
abstract: MRI of the brain was performed on 56 children with bilateral spastic cerebral palsy (CP) at a mean age of 10.7 years. Specific pathology was found in 91 per cent; periventricular leukomalacia was present in 42 per cent of term- and 87 per cent of preterm-born children. Parasagittal subcorticocortical injury, multicystic encephalomalacia and basal ganglia lesions were identified in 16 per cent, in all but one associated with severe peri-/neonatal events at term or near term. Maldevelopment comprised 9 per cent, all but one found in term-born children. MRI morphology correlated strikingly with outcome. Periventricular leukomalacia was associated with more severe disability in term- than preterm-born children.
authors.affiliation: Department of Child Neurology, University of Tübingen, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Krägeloh-Mann
authors.forename: D
authors.initials: D
authors.lastname: Petersen
authors.forename: G
authors.initials: G
authors.lastname: Hagberg
authors.forename: B
authors.initials: B
authors.lastname: Vollmer
authors.forename: B
authors.initials: B
authors.lastname: Hagberg
authors.forename: R
authors.initials: R
authors.lastname: Michaelis
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002547:Cerebral Palsy / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009128:Muscle Spasticity / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D012720:Severity of Illness Index