title: Plasma amino acid imbalance in patients with lung and breast cancer.
abstract: In order to evaluate whether different solid tumors may specifically influence plasma free amino acid (PFAA) profile, PFAA were analysed in seventy-four patients with lung (41 patients) and breast cancer (33 patients) and 28 healthy subjects. In lung cancer patients a significant reduction of gluconeogenic amino acids, threonine, serine, glycine and a significant increase of free tryptophan and glutamic acid was found. In breast cancer patients a significant increase of ornithine, glutamic acid and free tryptophan was found. The comparison of PFAA profiles between lung and breast cancer suggests that different tumors have a different influence on the host's PFAA pattern.
authors.affiliation: III Dept. of Internal Medicine, University La Sapienza, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cascino
authors.forename: M
authors.initials: M
authors.lastname: Muscaritoli
authors.forename: C
authors.initials: C
authors.lastname: Cangiano
authors.forename: L
authors.initials: L
authors.lastname: Conversano
authors.forename: A
authors.initials: A
authors.lastname: Laviano
authors.forename: S
authors.initials: S
authors.lastname: Ariemma
authors.forename: M M
authors.initials: MM
authors.lastname: Meguid
authors.forename: F
authors.initials: F
authors.lastname: Rossi Fanelli
mesh_terms: D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood*; D005260:Female; D005943:Gluconeogenesis; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism
chemical_list: D000596:Amino Acids; D009124:Muscle Proteins; D009363:Neoplasm Proteins