Chromosome aberrations in cultured rat bone marrow cells treated with inorganic fluorides.
The genotoxic effects of inorganic fluorides were investigated by treating cultured rat bone marrow cells with varying concentrations (0.1-100 microM) of potassium fluoride (KF) and sodium fluoride (NaF) for different durations (12, 24 and 36 h) and measuring the incidence of cells with aberrations and number of breaks per cell. Both forms of fluoride were found to be weak mutagens relative to the positive control N-methyl-N-nitro-N-nitrosoguanidine (MNNG). A specificity of fluoride ion in inducing chromosome aberrations (CA) was indicated by the observation that both NaF and KF behaved almost equivalently in this study and at significantly higher variations from the results with potassium chloride (KCl) and sodium chloride (NaCl).
Khalil
A M
AM
Department of Biological Sciences, Yarmouk University, Irbid, Jordan.
D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D005459:Fluorides / Q000633:toxicity*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens; D017680:Potassium Compounds / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012969:Sodium Fluoride / Q000633:toxicity*
D009153:Mutagens; D017680:Potassium Compounds; D008769:Methylnitronitrosoguanidine; D012969:Sodium Fluoride; C033320:potassium fluoride; D005459:Fluorides