Influence of thiols on the chlorinating effect of a myeloperoxidase system.
The structure-activity relationships for the interactions of a number of sulfhydryl compounds on the transformation of (Z)-3-(4-bromophenyl)-3-(3-pyridyl)allylamine (CPP 200) by an MPO-H2O2-Cl-(-)system at pH 5.25 have been studied. It was found that the inhibitory effect of the thiol group was strongly dependent on the presence of an electron-withdrawing NH3(+)-group in the molecule. Also, the acid-base properties of the thiolic compounds were involved in the inhibitory mechanisms.
Lindvall
S
S
Preclinical R & D, Astra Arcus AB, Sweden.
Rydell
G
G
D000143:Acids; D001711:Biotransformation; D002713:Chlorine / Q000737:chemistry; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D009195:Peroxidase / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D015031:Zimeldine / Q000031:analogs & derivatives* / Q000378:metabolism
D000143:Acids; D013438:Sulfhydryl Compounds; D015031:Zimeldine; D002713:Chlorine; C091651:3-(4-bromophenyl)-3-(3-pyridyl)allylamine; D009195:Peroxidase