Erythema-multiforme-like, urticarial papular and plaque eruptions from bufexamac: report of 4 cases.
4 patients developed an erythema-multiforme-like reaction following acute contact dermatitis from 2 different bufexamac-containing topical preparations. Histologically, the lesions did not show changes that were typical of erythema multiforme. Patch testing gave positive reactions to bufexamac at 1, 2, 3 and 4 days. The histological picture of 2 positive test reactions was suggestive of a drug reaction in the 1st, and of an acute eczematous reaction in the 2nd, case. A systemic allergic reaction with spread of lesions could have been involved, following percutaneous absorption of the allergen.
Koch
P
P
Hautklinik der Universität des Saarlandes, Homburg/Saar, Germany.
Bahmer
F A
FA
D000328:Adult; D002019:Bufexamac / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D004892:Erythema Multiforme / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests
D002019:Bufexamac