title: Whole cell assays in screening for biologically active substances.
abstract: This past year has seen a number of new developments in recombinant cell based assays. Lead compounds are beginning to be identified using mechanism-based whole cell assays to discover inhibitors of cellular processes, such as transactivation and signaling. These assays offer advantages for many targets over subcellular assay systems with purified macromolecules.
authors.affiliation: Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
authors.forename: R P
authors.initials: RP
authors.lastname: Hertzberg
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis; D001681:Biological Assay; D006801:Humans; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents