title: Brief wakeful response to command indicates wakefulness with suppression of memory formation during surgical anesthesia.
abstract: OBJECTIVE
  In a previous study of patients emerging from anesthesia following surgery, we found that a brief wakeful response to command of an eye opening or single hand squeeze or count was not associated with memory formation, while the response of four hand squeezes or counts was associated with memory. We wanted to determine the anesthetic requirements for obtaining this brief wakeful response endpoint during surgery and to determine if memory occurred at this endpoint during surgical anesthesia.
  
  
  METHODS
  Six different combinations of isoflurane, 70% N2O, and fentanyl were administered to 326 patients undergoing pelvic laparoscopy. After insertion of the trocar, anesthesia was reduced while patients were given verbal commands, and they were observed for movement responses to surgery and to command. Patients were classified as either not arousing, arousing with a movement response to surgery, or arousing with a wakeful response to command. For the patients who aroused, we calculated the percentage of arousal responses that were wakeful responses to command. The effect of fentanyl dosage upon the percentage of arousal responses that were wakeful responses to command was determined by using a Mann-Whitney test to compare a group of patients receiving fentanyl 2 micrograms/kg or less, with a group receiving fentanyl 4 micrograms/kg. In a subset of 39 patients, the potential for memory formation was evaluated by presenting a target sound to 29 patients during a period of either no arousal, movement response to surgery, or wakeful response to command; for a control group of 10 patients, no target sound was presented. All 39 patients were tested for memory of the target sound; the results from each group receiving a target sound were compared with the results of the control group, using a Mann-Whitney test.
  
  
  RESULTS
  A total of 68 patients aroused with either a movement response or a wakeful response to command. Wakeful responses occurred with only 1 of 39 patients (3%) receiving fentanyl 2 micrograms/kg or less; but, wakeful responses occurred with 17 of 29 patients (59%) receiving fentanyl 4 micrograms/kg. The difference between the groups was significant at p = 0.01. None of the 68 patients had recall of intraoperative events or unpleasant dreams. None of these patients who were in the multiple-choice memory subset recalled the target sound. There were no statistically significant differences on the multiple-choice memory test between the groups presented with the target sound and the control group. Patient anecdotes suggested that some patients may have had memory of the target sound; but, memory was no more likely in patients with a brief wakeful response to command than in those who responded with a movement to surgical stimulation or those who did not have an arousal response.
  
  
  CONCLUSIONS
  A brief wakeful response to a command of opening the eyes or squeezing the hand was not associated with increased memory formation during surgery. A brief wakeful response to command was found during surgery when patients received fentanyl 4 micrograms/kg; but it was rarely found at fentanyl dosages of 2 micrograms/kg or less.
authors.affiliation: Department of Anesthesia, Kaiser Permanente Medical Center, Hayward, CA 94545, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Dutton
authors.forename: W D
authors.initials: WD
authors.lastname: Smith
authors.forename: N T
authors.initials: NT
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D001143:Arousal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005283:Fentanyl; D006801:Humans; D007530:Isoflurane; D010535:Laparoscopy; D008568:Memory / Q000187:drug effects; D016343:Monitoring, Intraoperative; D009609:Nitrous Oxide; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects
chemical_list: D007530:Isoflurane; D009609:Nitrous Oxide; D005283:Fentanyl