title: Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors.
abstract: The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood levels of ubiquinone. Thirty-four unrelated outpatients with hypercholesterolemia (IIa phenotype) were treated with 20 mg of simvastatin for a 6-month period (group S) or with 20 mg of simvastatin plus 100 mg CoQ10 (group US). The following parameters were evaluated at time 0, 45, 90, 135 and 180 days: total plasma cholesterol (TC), HDL-cholesterol, LDL-cholesterol (LDL-C), triglycerides (TG), apo A1, apo B and CoQ10 in plasma and platelets. In the S group, there was a marked decrease in TC and LDL-C (from 290.3 mg/dl to 228.7 mg/dl for TC and from 228.7 mg/dl to 167.6 mg/dl for LDL-C) and in plasma CoQ10 levels from 1.08 mg/dl to 0.80 mg/dl. In contrast, in the US group we observed a significant increase of CoQ10 in plasma (from 1.20 to 1.48 mg/dl) while the hypocholesterolemic effect was similar to that observed in the S group. Platelet CoQ10 also decreased in the S group (from 104 to 90 ng/mg) and increased in the US group (from 95 to 145 ng/mg). This study demonstrates that simvastatin lowers both LDL-C and apo B plasma levels together with the plasma and platelet levels of CoQ10, and that CoQ10 therapy prevents both plasma and platelet CoQ10 decrease, without affecting the cholesterol lowering effect of simvastatin.
authors.affiliation: Dipartimento di Medicina Interna, Universita' di Bologna, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Bargossi
authors.forename: G
authors.initials: G
authors.lastname: Grossi
authors.forename: P L
authors.initials: PL
authors.lastname: Fiorella
authors.forename: A
authors.initials: A
authors.lastname: Gaddi
authors.forename: R
authors.initials: R
authors.lastname: Di Giulio
authors.forename: M
authors.initials: M
authors.lastname: Battino
mesh_terms: D001055:Apolipoproteins B / Q000097:blood; D001059:Apoproteins / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry; D002784:Cholesterol / Q000097:blood; D003067:Coenzymes; D018592:Cross-Over Studies; D004562:Electrocardiography; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D009211:Myoglobin / Q000097:blood; D010084:Oxidation-Reduction; D019821:Simvastatin; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001055:Apolipoproteins B; D001059:Apoproteins; D003067:Coenzymes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008074:Lipoproteins; D009211:Myoglobin; D014280:Triglycerides; D014451:Ubiquinone; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin; C024989:coenzyme Q10