Prevalence of acquired cystic kidney disease and tumors in native kidneys of renal transplant recipients: a prospective US study.
OBJECTIVE
To determine the prevalence of acquired cystic kidney disease (ACKD) and renal neoplasms in the native kidneys of renal transplant recipients.


METHODS
The ultrasound (US) scans in 385 renal allograft recipients were prospectively studied. In addition, 65 patients with ACKD underwent two additional US examinations on different days to assess intra- and interobserver variability with regard to the number of cysts and their diameter.


RESULTS
ACKD was present in 96 of 385 patients. Patients with ACKD were significantly older than patients without ACKD, had undergone hemodialysis for a longer period, and were predominantly men. There was no significant difference in the time with functioning graft. Renal cell carcinoma (RCC) was diagnosed in six patients at histologic examination. Of these six patients, five had evidence of ACKD.


CONCLUSIONS
The frequency of ACKD increases with the duration of hemodialysis. The risk for the development of ACKD is increased in men and older patients. The malignant potential of ACKD persists after renal transplantation.
Heinz-Peer
G
G
Department of Radiology, Universitätsklinik für Radiodiagnostik, Vienna, Australia.
Schoder
M
M
Rand
T
T
Mayer
G
G
Mostbeck
G H
GH
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D052177:Kidney Diseases, Cystic / Q000000981:diagnostic imaging*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D006435:Renal Dialysis; D014463:Ultrasonography
D007166:Immunosuppressive Agents