title: Circumscribed low grade astrocytomas in the dominant opercular and insular region: a pilot study.
abstract: Intraoperative mapping techniques allow a reliable identification or exclusion of eloquent brain areas and are well tolerated by the patients. In dominant opercular tumours radical surgery can only be achieved without lasting deficits with intraoperative histological examination of the resection line and mapping. If an early postoperative MRI shows residual opercular tumour in non-eloquent areas re-operation is recommended. In large dominant insular or opercular-insular tumours only biopsy is recommended, because only an incomplete removal can be accomplished, because the trial of radical removal carries a high risk of postoperative deficits due to possible vascular damage of the lenticulo-striate arteries or internal capsule. Because subtotal removal of low grade gliomas does not increase the progression free interval, we would not recommend surgery in these cases, as they carry a significant risk of a further deficit.
authors.affiliation: Department of Neurosurgery, University of Berne, Inselspital, Switzerland.
authors.forename: U
authors.initials: U
authors.lastname: Ebeling
authors.forename: K
authors.initials: K
authors.lastname: Kothbauer
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001706:Biopsy; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology