title: Electron crystallography of macromolecules.
abstract: Numerous technical advances in electron crystallography have facilitated determination of the three-dimensional structures of macromolecules, especially those that form two-dimensional or helical periodic arrays. Several recent studies have demonstrated the utility of this technique for visualizing secondary structure such as alpha-helices and beta-sheets of membrane proteins and, in one case, the entire polypeptide backbone. Electron crystallography, therefore, has great potential as a tool for studying structural problems that are relevant to both molecular biology and biotechnology.
authors.affiliation: Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: W
authors.initials: W
authors.lastname: Chiu
authors.forename: M F
authors.initials: MF
authors.lastname: Schmid
mesh_terms: D001709:Biotechnology; D003461:Crystallography / Q000379:methods*; D004583:Electrons; D007091:Image Processing, Computer-Assisted; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D011506:Proteins