title: Zidovudine for the treatment of HIV-negative patients with psoriasis: a pilot study.
abstract: BACKGROUND
  Zidovudine, an inhibitor of HIV replication, has been reported to improve psoriasis in HIV-positive patients.
  
  
  OBJECTIVE
  Our purpose was to evaluate the safety, tolerance, and effectiveness of oral zidovudine for treating psoriasis in HIV-negative patients in a small, open-label study.
  
  
  METHODS
  Each subject received 200 mg of zidovudine every 4 hours during waking hours, for a total of 1000 mg/day. Treatment was continued for 8 weeks, at which time the patient's response to therapy was evaluated. If a response was evident, treatment was continued for an additional 8 weeks. Clinical response was correlated with histologic changes in skin lesions at 0 and 4 weeks.
  
  
  RESULTS
  Thirty-three percent of HIV-negative patients with psoriasis showed improvement by up to 80% after 16 weeks of therapy; decreased elevation and scaling of the psoriasis plaques were the most notable changes. No complete remissions occurred.
  
  
  CONCLUSIONS
  This is the first report of the use of zidovudine to treat HIV-negative patients with psoriasis. Although zidovudine was well tolerated, it may be more effective in HIV-positive patients with psoriasis.
authors.affiliation: Department of Dermatology, University of Texas-Houston Medical School 77030, USA.
authors.forename: B L
authors.initials: BL
authors.lastname: Townsend
authors.forename: P R
authors.initials: PR
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Duvic
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D015215:Zidovudine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D015215:Zidovudine