title: Bronchial dysplasia induced by radiation in miners exposed to 222Rn progeny.
abstract: OBJECTIVE
  To investigate whether sputum cytology can be used to monitor epithelial cell changes in groups at high risk of lung cancer from exposure to radiation.
  
  
  METHODS
  Dysplasia of bronchial cells was investigated by means of sputum cytology in a group of 434 underground miners. 100 of them were not exposed, and 334 were exposed to 222Rn progeny at cumulative exposures < 450 working level months.
  
  
  RESULTS
  The frequency of dysplasia in the exposed group was significantly higher than that in the not exposed group (P < 0.0001), and an exposure-response relation was found. This relation was different for smokers and non-smokers.
  
  
  CONCLUSIONS
  Possibly the frequencies of dysplasia could be used to assess past exposures of groups of miners. This approach could be applied to cases where data on radiation monitoring are not available or are very scarce.
authors.affiliation: Department of Radiation Hygiene, Hygienic and Epidemiology Inspection, Ministry of Health, Sofia-Bouchovo, Bulgaria.
authors.forename: M A
authors.initials: MA
authors.lastname: Michaylov
authors.forename: D S
authors.initials: DS
authors.lastname: Pressyanov
authors.forename: K B
authors.initials: KB
authors.lastname: Kalinov
mesh_terms: D000328:Adult; D015331:Cohort Studies; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D008906:Mining; D009784:Occupational Diseases / Q000139:chemically induced*; D017687:Radon Daughters / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013183:Sputum / Q000166:cytology
chemical_list: D017687:Radon Daughters