title: [Efficacy of the combination of mitomycin, ifosfamide and cisplatin with irradiation for the treatment of cerebral metastasis in non small cell lung carcinoma].
abstract: We initiated prospective study testing efficacy of multidrug chemotherapy (cisplatin, ifosfamide, mitomycin) with irradiation in brain metastases of non small cell lung cancer at first diagnosis. Among 22 patients we obtained ten objective local responses (45%). Median survival was 7 months. Toxicity was mild (> 2 - OMS): hematologic = five patients; gastrointestinal = one patient. Among 11 patients who received chemotherapy before radiotherapy we had seven objective responses (patients evaluated after three courses of chemotherapy and before radiotherapy). This result indicates the interest of this protocol of chemotherapy in brain metastases. The association of this protocol of chemotherapy and radiotherapy appears effective, well tolerated and few toxic.
authors.affiliation: Unité d'oncologie médicale, hôpital Laënnec, CHRU, Nantes, France.
authors.forename: I
authors.initials: I
authors.lastname: Cumin
authors.forename: H
authors.initials: H
authors.lastname: Lacroix
authors.forename: M
authors.initials: M
authors.lastname: Mahé
authors.forename: J P
authors.initials: JP
authors.lastname: Dutin
authors.forename: G
authors.initials: G
authors.lastname: Dabouis
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000008:administration & dosage; D009367:Neoplasm Staging; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D012074:Remission Induction; D015996:Survival Rate
chemical_list: D008937:Mitomycins; D002945:Cisplatin; D007069:Ifosfamide
vernacular_title: Efficacité de l'association mitomycine, ifosfamide, cisplatine avec irradiation pour le traitement des métastases cérébrales des cancers bronchiques non à petites cellules.