title: Activation of the basolateral Cl- conductance by cyclic AMP in rabbit renal proximal tubule S3 segment.
abstract: The regulation of basolateral Cl- conductance in renal proximal tubule was investigated by microelectrodes. Our results suggest that this conductance can be activated by cAMP, while increase in cell Ca2+ or activation of PKC has no effect. These properties of this conductance also suggest that CFTR may exist in the basolateral membrane of proximal tubule.
authors.affiliation: First Department of Internal Medicine, University of Tokyo, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Seki
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
authors.forename: S
authors.initials: S
authors.lastname: Uwatoko
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
mesh_terms: D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology; D000818:Animals; D018118:Chloride Channels / Q000502:physiology*; D000242:Cyclic AMP / Q000494:pharmacology*; D003550:Cystic Fibrosis; D007668:Kidney / Q000502:physiology*; D008839:Microelectrodes; D011817:Rabbits
chemical_list: D018118:Chloride Channels; D000242:Cyclic AMP; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid