Balanced nonacrocentric whole-arm reciprocal translocations: a de novo case and literature review.
We report a new de novo case of a balanced whole-arm reciprocal translocation, detected at prenatal diagnosis for late maternal age. A review of previous cases indicates there is a risk of chromosomally abnormal liveborn offspring when a parent is a carrier of this type of translocation, particularly when the translocated region is a small chromosomal segment. Due to the limited number of cases, exact reproductive risks are not available. This is the second example of such a translocation of chromosomes 1 and 5, raising the possibility of nonrandom involvement of certain chromosomes in balanced nonacrocentric whole-arm reciprocal translocations.
Farrell
S A
SA
Division of Genetics, Credit Valley Hospital, Mississauga, Ontario, Canada.
Fan
Y S
YS
D000649:Amniocentesis; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D014178:Translocation, Genetic