Effects of cholinergic and adrenergic agonists on the secretion of fluid and protein by submandibular glands of the guinea-pig and the mouse.
Significant differences were observed between the guinea-pig and the mouse in terms of the secretion of fluid, protein and secretory granules from submandibular glands in response to pilocarpine, phenylephrine and isoproterenol. In both the guinea-pig and the mouse, the secretory responses induced by pilocarpine, phenylephrine and isoproterenol were inhibited by pretreatment with 4-DAMP, phentolamine and propranolol, respectively. The results suggest that the submandibular glands of the guinea-pig and the mouse have M3-cholinoreceptors, as well as alpha- and beta-adrenoceptors, and that these receptors play different roles in the secretion of fluid, protein and secretory granules from guinea-pig and mouse submandibular glands.
Iwabuchi
Y
Y
Department of Dental Pharmacology, School of Dentistry, Nippon Dental University, Niigata, Japan.
Iwasaki
S
S
Masuhara
T
T
D000322:Adrenergic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D018679:Cholinergic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011506:Proteins / Q000378:metabolism; D012472:Salivation / Q000187:drug effects; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*
D000322:Adrenergic Agonists; D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D018679:Cholinergic Agonists; D011506:Proteins