Hyaluronic acid modulates acute and chronic inflammation.
We have studied the effect of hyaluronic acid (HA) in two standard models of acute and chronic inflammation in the rat, i.e. carrageenin oedema and adjuvant arthritis. Our results show that HA was able to inhibit, in a dose-related fashion, both types of inflammatory reactions. These findings suggest that HA may have a modulatory role in the inflammatory process and may explain, at least in part, the protective role of HA in the inflammatory cartilage damage.
Ialenti
A
A
Department of Experimental Pharmacology, University of Naples, Federico II, Italy.
Di Rosa
M
M
D000208:Acute Disease; D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D002351:Carrageenan / Q000633:toxicity; D002908:Chronic Disease; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005620:Freund's Adjuvant / Q000633:toxicity; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D002351:Carrageenan; D006820:Hyaluronic Acid; D005620:Freund's Adjuvant; D008775:Methylprednisolone; D007213:Indomethacin