A three dimensional model for the interaction of MSH with the melanocortin-1 receptor.
A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling using bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into a binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in TM3 of receptor with histidine in cyclic MSH-peptide, H260 in TM6 with glutamic in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.
Prusis
P
P
Department of Pharmaceutical Pharmacology, Uppsala University, Sweden.
Frändberg
P A
PA
Muceniece
R
R
Kalvinsh
I
I
Wikberg
J E
JE
D000595:Amino Acid Sequence; D003198:Computer Simulation; D008024:Ligands; D009074:Melanocyte-Stimulating Hormones / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011979:Receptors, Pituitary Hormone / Q000378:metabolism / Q000648:ultrastructure*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D008024:Ligands; D010456:Peptides, Cyclic; D011979:Receptors, Pituitary Hormone; C029446:MSH receptor; D009074:Melanocyte-Stimulating Hormones