title: 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities.
abstract: The synthesis of novel 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles 4a-f, starting from N-phenyl-3,4-dihydro-1(2H)-oxonaphthalene-2-carbothioamide and the proper arylhydrazines, is described. Title compounds were evaluated for antiinflammatory, analgesic, antipyretic, antiarrhythmic, hypotensive, local anaesthetic and platelet antiaggregating activities; some of them showed an appreciable antiarrhythmic activity in rats and a good level of infiltration anaesthesia in mice.
authors.affiliation: Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Schenone
authors.forename: O
authors.initials: O
authors.lastname: Bruno
authors.forename: A
authors.initials: A
authors.lastname: Ranise
authors.forename: F
authors.initials: F
authors.lastname: Bondavalli
authors.forename: M
authors.initials: M
authors.lastname: D'Amico
authors.forename: W
authors.initials: W
authors.lastname: Filippelli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: V
authors.initials: V
authors.lastname: De Novellis
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000494:pharmacology; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control; D007191:Indazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D000814:Aniline Compounds; D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D007191:Indazoles; D010975:Platelet Aggregation Inhibitors; D002351:Carrageenan