title: The effects of 3g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension.
abstract: OBJECTIVE
  To study the effects of addition of 3 g eicosapentaenoic acid daily to the diet, on recurrence rate of intrauterine growth retardation and pregnancy induced hypertension in a high risk population.
  
  
  METHODS
  Prospective, double blind, randomised multicentre study. Eicosapentaenoic acid or placebo were given from 12 to 14 weeks of gestation onwards.
  
  
  METHODS
  University Hospital and regional hospitals in the north of the Netherlands.
  
  
  METHODS
  Sixty-three women with a history of intrauterine growth retardation (birthweight < 10th centile) with or without pregnancy induced hypertension in the previous pregnancy.
  
  
  METHODS
  Birthweight centiles and signs of pregnancy induced hypertension in current pregnancy.
  
  
  RESULTS
  One-third of the women developed pregnancy induced hypertension and one-third of the infants had a birthweight below the 10th centile. There were no differences between eicosapentaenoic acid and placebo group.
  
  
  CONCLUSIONS
  Addition of 3 g eicosapentaenoic acid daily does not prevent recurrence of intrauterine growth retardation or pregnancy induced hypertension in a high risk population.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital, Groningen, The Netherlands.
authors.forename: M T
authors.initials: MT
authors.lastname: Bulstra-Ramakers
authors.forename: H J
authors.initials: HJ
authors.lastname: Huisjes
authors.forename: G H
authors.initials: GH
authors.lastname: Visser
mesh_terms: D001724:Birth Weight; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005317:Fetal Growth Retardation / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D007231:Infant, Newborn; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000517:prevention & control*; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D015118:Eicosapentaenoic Acid