title: Severe diltiazem poisoning with intestinal pseudo-obstruction: case report and toxicological data.
abstract: This case report concerns a 30-year-old man who survived a 4.2 g diltiazem overdose. He sustained vasoplegic shock with a junctional escape rhythm which required high doses of norepinephrine and epinephrine. Among other complications, ileus with paralytic intestinal pseudo-obstruction developed on day three. Cecal distention was demonstrated by abdomen computed tomodensitometry. The ileus resolved on day seven following the poisoning. Diltiazem plasma concentrations were determined during the first three days. The possible role of other medications, activated charcoal and sufentanil, is noted.
authors.affiliation: Department of Intensive Care, Cliniques Universitaires St-Luc, Brussels, Belgium.
authors.forename: J P
authors.initials: JP
authors.lastname: Fauville
authors.forename: P
authors.initials: P
authors.lastname: Hantson
authors.forename: P
authors.initials: P
authors.lastname: Honore
authors.forename: F
authors.initials: F
authors.lastname: Belpaire
authors.forename: M T
authors.initials: MT
authors.lastname: Rosseel
authors.forename: P
authors.initials: P
authors.lastname: Mahieu
mesh_terms: D000328:Adult; D002429:Cecal Diseases / Q000139:chemically induced*; D004110:Diltiazem / Q000506:poisoning*; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced*; D008297:Male
chemical_list: D004110:Diltiazem