title: [Posterior cortical atrophy with progressive visual agnosia].
abstract: Interest in progressive focal cerebral syndromes associated with classical degenerative diseases has increased in recent years. Descriptions of posterior cortical atrophy with progressive visual agnosia are relatively rare. We present 5 patients (2 women) ranging in age between 57 and 72 years old. In all cases symptoms began and progressed with no known etiology. All cases were sporadic. The main clinical signs are difficulty in recognizing objects, colors, persons or places; topographical disorientation and visual memory alterations; alexia, simultagnosia, loss of ocular fixing and optic ataxia. Some patients presented other disturbances of praxis or memory and 2 progressed to global dementia. Language function was preserved and behavioral disturbances did not develop. The amplitude of the P100 visual evoked potential was low but latency was normal in 4 patients and prolonged in 1. Brain images showed atrophy and hypoperfusion in the parieto-occipital area. The neuropathology status of these patients is unknown.
authors.affiliation: Hospital de Cruces, Departamento de Neurociencias, Universidad del País Vasco.
authors.forename: J J
authors.initials: JJ
authors.lastname: Zarranz
authors.forename: A
authors.initials: A
authors.lastname: Lasa
authors.forename: M
authors.initials: M
authors.lastname: Fernández
authors.forename: E
authors.initials: E
authors.lastname: Lezcano
authors.forename: M
authors.initials: M
authors.lastname: Pérez Bas
authors.forename: L
authors.initials: L
authors.lastname: Varona
authors.forename: J
authors.initials: J
authors.lastname: Ruiz
authors.forename: X
authors.initials: X
authors.lastname: Beristain
mesh_terms: D000328:Adult; D000368:Aged; D000377:Agnosia / Q000150:complications* / Q000503:physiopathology; D001072:Apraxias / Q000150:complications; D001284:Atrophy / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D003118:Color Perception; D003704:Dementia / Q000150:complications; D005074:Evoked Potentials, Visual; D005260:Female; D005403:Fixation, Ocular; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000150:complications; D008875:Middle Aged; D009778:Occipital Lobe / Q000098:blood supply / Q000503:physiopathology*; D010296:Parietal Lobe / Q000098:blood supply / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon
vernacular_title: Atrofia cortical posterior con agnosia visual progresiva.