Synthesis and antihypertensive activity evaluation of indole derivatives N-acetamido substituted.
The synthesis of a series of 1-(alkyl- or aryl-aminocarbonylmethyl)-2-methyl- or 2-phenyl-indoles are described. All compounds were tested for antihypertensive activity on spontaneously hypertensive rats (SHR) and some of them showed a significant reduction of the arterial pressure.
Grasso
S
S
Dipartimento Farmaco-Chimico, Università di Messina, Italy.
Molica
C
C
Monforte
A M
AM
Monforte
P
P
Zappalà
M
M
Monforte
M T
MT
Trovato
A
A
D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D011918:Rats, Inbred SHR; D013329:Structure-Activity Relationship
D000081:Acetamides; D000959:Antihypertensive Agents; D007211:Indoles