[A histopathological study on postoperative recurrence of hepatocellular carcinoma--an evaluation based on multivariate analysis].
On postoperative recurrence of hepatocellular carcinoma (HCC), a multivariate analysis of Cox's regression model was conducted to determine the prognostic factors using histopathological findings of HCC and disease-free survival period. There were 105 males and 14 females (mean age +/- standard deviation: 56.1 +/- 8.2 yr) who had curative resection of HCC from 1979 to 1989. The histopathological findings were 11 factors as follows; (1) diameter (2) number (3) histology (4) Edmondson classification (5) fc (6) fc-inf (7) sf (8) sf-inf (9) v (10) daughter nodule and (11) necrotic ration. From this analysis, among 11 histopathological parameters, only diameter of HCC (p = 0.0029) was identified as a favorable independent prognostic predictor. Regarding to the tumor size with the hazard ratio, the tumor size of 4cm or less is seen to be the satisfactory means for assessing long-term disease-free survival of HCC.
Nakaichi
H
H
Second Department of Surgery, Chiba University School of Medicine, Japan.
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011379:Prognosis; D012044:Regression Analysis