[Ineffectiveness of ACE inhibitors (enalapril) on glomerular damage in rats after a 5/6 nephrectomy and a high-salt diet].
Wistar rats with surgically removed 5/6 of renal parenchyma were fed either standard (0.35% salt content) or a high-salt (2%) diet. Half of the animals of each group drunk plain water while the other half was provided water enriched with the angiotensin-converting enzyme inhibitor enalapril (ENA) at a dose of 5 mg/kg/day. In rats receiving standard diet, ENA had a significant inhibitory effect on the consequences of ablation: the rats had normal blood pressure, low proteinuria, and high endogenous creatinine clearance compared to water-drinking controls. The high-salt diet significantly enhanced the sequelae of ablation: a high blood pressure and proteinuria, low clearance, which ENA was unable to prevent in these animals. No plausible explanation for the absence of ENA's beneficial effect is available: one can speculate that, under conditions of high-salt intake, the activity of the renin-angiotensin system is suppressed leaving no place for ENA to exert its effect. We also believe that the highly adverse effect of a high-salt diet in chronic renal failure is due to growth factors other than angiotensin II.
Cervenka
L
L
Pracovistĕ preventivní kardiologie IKEM, Praha.
Heller
J
J
Hellerová
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003404:Creatinine / Q000378:metabolism; D004656:Enalapril / Q000494:pharmacology*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000503:physiopathology; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage* / Q000009:adverse effects; D014508:Urea / Q000378:metabolism
D017673:Sodium Chloride, Dietary; D004656:Enalapril; D014508:Urea; D003404:Creatinine
Neúcinnost ACEI (enalaprilu) na průbĕh glomerulárního poskození u krys po 5/6 nefrektomii, krmených vysokoslanou dietou.