Dithiothreithol promotes a higher affinity state of the serotonin transporter for the tricyclic antidepressant, imipramine.
Tarrant
H M
HM
Department of Biochemistry, Trinity College, Dublin 2, Ireland.
Williams
D C
DC
D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004229:Dithiothreitol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007099:Imipramine / Q000378:metabolism*; D007700:Kinetics; D008562:Membrane Glycoproteins / Q000187:drug effects / Q000378:metabolism*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; D007099:Imipramine; D004229:Dithiothreitol