Glycoprotein B of bovine herpesvirus-1 binds heparin.
Many members of the herpesvirus family have been shown to bind heparan sulfate on the surface of target cells. A previous report on bovine herpesvirus-1 (BHV-1) glycoprotein interactions indicated that only gC bound to heparin-agarose columns. In this report, we demonstrated that both gC and gB of wild-type BHV-1 bound to heparin-agarose columns and that gC-minus virus infectivity was inhibited by heparin.
Byrne
K M
KM
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
Horohov
D W
DW
Kousoulas
K G
KG
D000327:Adsorption; D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000821:virology; D002478:Cells, Cultured; D006493:Heparin / Q000378:metabolism*; D007242:Herpesvirus 1, Bovine / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D009154:Mutation; D011485:Protein Binding; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
D014759:Viral Envelope Proteins; D014764:Viral Proteins; C046998:bovine herpesvirus type-1 glycoproteins; D006493:Heparin