[Cholestyramine for digoxin intoxication].
Cholestyramine, a bile acid sequestering resin, has been reported to bind digitalis in vitro. We gave 4 g every 6 hours to 3 patients with non-life threatening digoxin intoxication. In all 3 serum digoxin concentrations and digoxin half-life decreased: from 50 to 32 hours, from 50 to 10 hours and from 46 to 16 hours in the 3 cases, respectively. Cholestyramine is potentially useful and safe adjunct medication for non-life threatening digoxin intoxication.
Krivoy
N
N
Medical Dept. A, Rambam Medical Center, Haifa.
Eisenman
A
A
D000368:Aged; D000369:Aged, 80 and over; D002792:Cholestyramine Resin / Q000008:administration & dosage / Q000627:therapeutic use*; D004077:Digoxin / Q000378:metabolism / Q000506:poisoning*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D011041:Poisoning / Q000188:drug therapy
D002792:Cholestyramine Resin; D004077:Digoxin