title: Clinical evidence of spinal and cerebral histoplasmosis twenty years after renal transplantation.
abstract: Disseminated infection with Histoplasma capsulatum frequently involves the nervous system, but the CNS process is generally not clinically apparent. We report an unusual case of a renal transplant recipient with long-standing immunosuppression who presented with clinical evidence of mass lesions in both his cerebral cortex and his spinal cord. Findings of CSF examination were normal, but stereotaxic biopsies of his cortical lesions demonstrated yeast forms and cultures of biopsy specimens yielded H. capsulatum. Clinical defects referable to both the cortical and spinal lesions decreased in severity after the patient received antifungal therapy. Our case illustrates that disseminated histoplasmosis can present in myriad ways and that widespread disease in the CNS can be occult in immunocompromised patients.
authors.affiliation: Department of Medicine, Veterans Affairs Medical Center, Iowa City, Iowa, USA.
authors.forename: I C
authors.initials: IC
authors.lastname: Livas
authors.forename: P S
authors.initials: PS
authors.lastname: Nechay
authors.forename: W M
authors.initials: WM
authors.lastname: Nauseef
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000855:Anorexia; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005500:Follow-Up Studies; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D011183:Postoperative Complications; D013118:Spinal Cord Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D015431:Weight Loss
chemical_list: D000666:Amphotericin B