Modulation of peripheral benzodiazepine receptor density by testosterone in Dunning G prostatic adenocarcinoma.
Effect of orchiectomy on peripheral benzodiazepine receptors (PBZr) density in hormone sensitive, poorly differentiated Dunning G rat prostatic tumors were studied. A significant increase in PBZr density (1.4-fold) was observed in both mitochondrial fractions (m-fractions) and microsomal fractions (p-fractions) of tumors from orchiectomized rats as compared to tumors from sham operated controls. Substitution with testosterone in orchiectomized rats repressed the PBZr density in both m- and p-fractions to that of the control animals. The data strongly suggest a regulatory role of testosterone on the PBZr density in these hormone sensitive prostatic tumors.
Alenfall
J
J
Department of Pharmacology, University of Lund, Sweden.
Batra
S
S
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009368:Neoplasm Transplantation; D009919:Orchiectomy; D011467:Prostate / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D011963:Receptors, GABA-A / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*
D011963:Receptors, GABA-A; D013739:Testosterone