title: Risk of human immunodeficiency virus (HIV) transmission by anti-HIV-negative blood components in Germany and Austria.
abstract: In order to estimate the residual risk of transfusion-transmitted HIV infection we have analyzed the data from two transfusion centers in Austria (Vienna) and Germany (Göttingen) from 1985 to 1994. In Vienna, an incidence of 1:42,000 positive anti-HIV tests in repeat donors and a prevalence of 1:7000 in first-time donors were found in 1993. In Göttingen, the indicence was 1:67,000 and the prevalence 1:7900 from 1985 to 1993. Based on a mathematical model which takes (a) the window period and (b) the false-negative rate of anti-HIV tests, as well as (c) human and operational errors into consideration, we have calculated the residual risk of HIV infection. The residual risk (third generation anti-HIV test) was found to be 1:520,000 (95% confidence interval 1:1340,000-1:210,000), and 1:900,000 (95% confidence interval 1:2340,000-1:380,000) for Vienna and Göttingen, respectively, in 1993. Look-back studies from 1985 till 1994 revealed transfusion-transmitted HIV infections in three recipients (for 1.9 million donations in Vienna) and one recipient (for 160,000 donations in Göttingen) of blood components. Based on our model, as well as on prevalence and incidence rates of HIV infection, it is also possible to predict the efficacy of additional measures introduced to further decrease the risk of transfusion-transmitted HIV infection through blood components.
authors.affiliation: Department of Transfusion Medicine, University of Göttingen, Germany.
authors.forename: D W
authors.initials: DW
authors.lastname: Schwartz
authors.forename: G
authors.initials: G
authors.lastname: Simson
authors.forename: K
authors.initials: K
authors.lastname: Baumgarten
authors.forename: H
authors.initials: H
authors.lastname: Fabritz
authors.forename: J
authors.initials: J
authors.lastname: Riggert
authors.forename: H
authors.initials: H
authors.lastname: Neumeyer
authors.forename: W R
authors.initials: WR
authors.lastname: Mayr
authors.forename: M
authors.initials: M
authors.lastname: Köhler
mesh_terms: D001317:Austria; D001782:Blood Donors; D005858:Germany; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission*; D018023:HIV Seronegativity; D006801:Humans; D012307:Risk Factors; D065227:Transfusion Reaction
chemical_list: D015483:HIV Antibodies