[Acute necrotizing enterocolitis during a prolonged treatment with neuroleptics].
A 32-year old man treated for several years with phenothiazine for chronic psychosis developed acute necrotizing colitis. The causal relationship with neuroleptics was reinforced by the absence of any other treatment and by histological findings including extensive mucosal necrosis without stenotic lesion and without mesenteric vessels alteration. The patient required emergency total colectomy and was discharged after 7 weeks of hospitalisation in the intensive care unit.
Ausseur
A
A
Service de Réanimation médicale et Maladies infectieuses, Centre Hospitalier de Tourcoing.
Leroy
C
C
Bazin
B
B
Sarraz-Bournet
B
B
Oureib
J
J
Georges
H
H
D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D010640:Phenothiazines; D011618:Psychotic Disorders / Q000188:drug therapy; D013997:Time Factors
D014150:Antipsychotic Agents; D010640:Phenothiazines
Entérocolite aiguë nécrosante au cours d'un traitement prolongé par neuroleptiques.