title: Effects of lorazepam on human contrast sensitivity.
abstract: The anxiolytic lorazepam was studied for its effects on contrast sensitivity to gratings flickering in counterphase in normal volunteers. The drug significantly reduced contrast sensitivity at low spatial frequencies in a dose-related manner. The results are discussed with reference to possible GABA-mediated processes in the retina and lateral geniculate nucleus.
authors.affiliation: Department of Psychology, University of Reading, Earley Gate, Whiteknights, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Haris
authors.forename: O T
authors.initials: OT
authors.lastname: Phillipson
mesh_terms: D000328:Adult; D015350:Contrast Sensitivity / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D010465:Perception / Q000187:drug effects; D011601:Psychophysics; D012684:Sensory Thresholds / Q000187:drug effects
chemical_list: D008140:Lorazepam