Involvement of potassium ions in the action of various antineoplastic drugs on the growth of Saccharomyces cerevisiae.
The involvement of potassium ions in the action of some antineoplastic drugs on the growth of Saccharomyces cerevisiae was studied by incubating yeast cells in the presence of drugs at various concentrations and KCl at concentrations of 50 mmol l-1 and 100 mmol l-1. The presence of 6.25-50 micrograms ml-1 amsacrine or melphalan alone in the culture medium had no significant effect on yeast growth. Addition of KCl significantly increased the sensitivity to these drugs. On the contrary, incubation of yeast cells with KCl had no effect on the cytotoxic action of doxorubicin, methotrexate or 5-fluorouracil.
Tiligada
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Department of Experimental Pharmacology, Athens University School of Medicine, Greece.
Delitheos
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A
D000677:Amsacrine / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D005472:Fluorouracil / Q000494:pharmacology; D008558:Melphalan / Q000494:pharmacology; D008727:Methotrexate / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development
D000970:Antineoplastic Agents; D000677:Amsacrine; D011189:Potassium Chloride; D004317:Doxorubicin; D008558:Melphalan; D005472:Fluorouracil; D008727:Methotrexate