title: Platelet [3H]paroxetine binding in panic disorder.
abstract: Platelet [3H]paroxetine binding was measured in 20 patients (14 females, six males) with panic disorder and 20 normal controls (14 females, six males). For patients with panic disorder, Bmax was 1987 +/- 1135 fmol/mg protein (mean +/- SD) compared with control Bmax values of 1626 +/- 611 fmol/mg protein. The mean Kd value for the patients was 0.076 +/- 0.056 nM and for the controls was 0.083 +/- 0.033 nM. ANCOVA indicated no significant effect of sex, diagnosis (panic disorder vs. normal controls) or season of sampling on either Kd or Bmax. The data provide no evidence for an abnormality of the platelet uptake mechanism in panic disorder.
authors.affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
authors.forename: K P
authors.initials: KP
authors.lastname: Maguire
authors.forename: T R
authors.initials: TR
authors.lastname: Norman
authors.forename: M
authors.initials: M
authors.lastname: Apostolopoulos
authors.forename: F K
authors.initials: FK
authors.lastname: Judd
authors.forename: G D
authors.initials: GD
authors.lastname: Burrows
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D016584:Panic Disorder / Q000097:blood*; D017374:Paroxetine / Q000097:blood*; D011869:Radioligand Assay; D014316:Tritium
chemical_list: D014316:Tritium; D017374:Paroxetine