[An unusual case of subacute sclerosing panencephalitis].
A 25-year-old man was admitted following deterioration in behavior and onset of blindness. He soon became comatose and died 6 weeks later. Brain biopsy showed nuclear inclusion bodies resembling viral capsids, astrocytosis and perivascular lymphocytic cuffing but no demyelination. The diagnosis of subacute sclerosing panencephalitis was made on finding: measles virus antigens in both serum and cerebrospinal fluid, the identification of measles RNA sequences in brain tissue by the polymerase chain reaction, and intense, oligoclonal, IgG-banding in the CSF. However, the relatively advanced age of the patient, the absence of myoclonus and the nondistinctive EEG profile lacking synchronous bursts of high-voltage slow and sharp waves, are unusual.
Sela
B A
BA
Dept. of Neurology, Chaim Sheba Medical Center, Tel Hashomer.
Hassin-Baer
S
S
Goldhamer
Y
Y
Polak-Charcon
S
S
Nass
D
D
Duvdevani
P
P
Shulman
L
L
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008459:Measles virus / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis
D000956:Antigens, Viral