Cytokine production profile of early thymocytes and the characterization of a new class of chemokine.
By using a variety of molecular techniques, we have characterized the cytokine profile of pro-T cells. During this characterization we cloned a novel cytokine that has chemotactic activities. We have designated this cytokine lymphotactin. The structural analysis, chromosomal location, and biological properties of lymphotactin provide strong evidence that this cytokine represents a new class of chemokine.
Kelner
G S
GS
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.
Zlotnik
A
A
D000818:Animals; D002454:Cell Differentiation; D054407:Chemokine CCL4; D019744:Chemokines, C; D003001:Cloning, Molecular; D016207:Cytokines / Q000096:biosynthesis* / Q000502:physiology; D018076:DNA, Complementary / Q000235:genetics; D015870:Gene Expression; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000502:physiology*; D019402:Macrophage Inflammatory Proteins; D051379:Mice; D015846:Monokines / Q000502:physiology; D012795:Sialoglycoproteins / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism*
D054407:Chemokine CCL4; D019744:Chemokines, C; D016207:Cytokines; D018076:DNA, Complementary; D008222:Lymphokines; D019402:Macrophage Inflammatory Proteins; D015846:Monokines; D012795:Sialoglycoproteins; C486249:Xcl1 protein, mouse; C018997:lymphotactin