title: The differential diagnosis of Alzheimer's disease. Cerebral atrophy versus normal pressure hydrocephalus.
abstract: This article summarizes the neuroradiology of Alzheimer's disease (AD) and details the radiologic features that permit the identification of patients with normal pressure hydrocephalus (NPH). Patients with presumed AD show a characteristic atrophy pattern with specific involvement of the temporal lobes and hippocampus. These findings have prognostic implications. Patients with NPH typically show severe motoric and gait deficits and initially mild cognitive impairment. Marked improvement is shown in select patients after ventricular shunting.
authors.affiliation: Department of Radiology, New York University Medical Center, New York, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: George
authors.forename: A
authors.initials: A
authors.lastname: Holodny
authors.forename: J
authors.initials: J
authors.lastname: Golomb
authors.forename: M J
authors.initials: MJ
authors.lastname: de Leon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D011379:Prognosis; D013702:Temporal Lobe / Q000473:pathology