title: Application of scanning transmission electron microscopy to the study of biological structure.
abstract: The scanning transmission electron microscope provides structural and chemical information of a specimen at atomic-scale resolution and complements conventional transmission electron microscopy techniques. Mass measurements can now be performed routinely on a wide range of molecular and supramolecular structures using elastically scattered electrons. Recent progress in the acquisition and analysis of electron energy-loss spectroscopy data indicates that the scanning transmission electron microscope is an efficient tool for mapping the chemical composition of biological samples.
authors.affiliation: M.E. Müller-Institute for High Resolution Electron Microscopy, University of Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Engel
authors.forename: C
authors.initials: C
authors.lastname: Colliex
mesh_terms: D001709:Biotechnology; D004583:Electrons; D007091:Image Processing, Computer-Assisted; D046911:Macromolecular Substances; D017348:Microscopy, Electron, Scanning Transmission / Q000295:instrumentation / Q000379:methods*; D015394:Molecular Structure; D008970:Molecular Weight; D012542:Scattering, Radiation
chemical_list: D046911:Macromolecular Substances