title: Urogenital manifestations of Wegener granulomatosis.
abstract: We report 8 patients with Wegener granulomatosis (WG) who suffered from symptomatic urogenital involvement including acute urinary retention related to prostatitis, orchitis, ureteral stenosis, bladder pseudotumor, and penile ulceration. Urogenital manifestations occurred as an isolated manifestation of WG in 4 patients, at the onset of the disease in 1 patient, and as the only symptom of relapse in 3. Data used to distinguish specific WG involvement from infection or cyclophosphamide urothelial toxicity are discussed. Four patients needed a surgical procedure consisting of suprapubic cystostomy for acute urinary retention, bilateral ureteral double J stents for bilateral ureteral stenosis, and prostate transurethral resection. Urogenital symptoms promptly resolved with medical therapy. High-dose corticosteroids and immunosuppressive drugs should be used as first-line therapy to avoid unnecessary surgery.
authors.affiliation: Department of Internal Medicine, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: D L
authors.initials: DL
authors.lastname: Huong
authors.forename: T
authors.initials: T
authors.lastname: Papo
authors.forename: J C
authors.initials: JC
authors.lastname: Piette
authors.forename: B
authors.initials: B
authors.lastname: Wechsler
authors.forename: O
authors.initials: O
authors.lastname: Bletry
authors.forename: F
authors.initials: F
authors.lastname: Richard
authors.forename: J C
authors.initials: JC
authors.lastname: Valcke
authors.forename: P
authors.initials: P
authors.lastname: Godeau
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D003556:Cystitis / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology*; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011472:Prostatitis / Q000209:etiology*; D012189:Retrospective Studies; D014517:Ureteral Obstruction / Q000209:etiology*
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone