title: Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro.
abstract: The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.
authors.forename: V C
authors.initials: VC
authors.lastname: Njar
authors.forename: T O
authors.initials: TO
authors.lastname: Alao
authors.forename: J I
authors.initials: JI
authors.lastname: Okogun
authors.forename: Y
authors.initials: Y
authors.lastname: Raji
authors.forename: A F
authors.initials: AF
authors.lastname: Bolarinwa
authors.forename: E U
authors.initials: EU
authors.lastname: Nduka
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005298:Fertility / Q000187:drug effects*; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007985:Leydig Cells / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D036702:Quassins; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000096:biosynthesis*
chemical_list: D036702:Quassins; D013739:Testosterone; D005900:Glaucarubin; C010317:quassin