title: Successful treatment with auranofin in a patient with elderly-onset Still's disease.
abstract: We report a successful treatment with auranofin in a case of elderly-onset Still's disease. The administration of non-steroidal anti-inflammatory drugs, mizoribine and prednisolone were not only insufficient to suppress the disease activity but were followed by the development of multiple gastric ulcers and severe osteoporosis. On the contrary, treatment with auranofin, 9 mg per day, was effective enough to maintain the disease inactive without any side effects. We also found that plasma levels of interleukin-6 and tumor necrosis factor-alpha were significantly elevated in our patient, suggesting a possible involvement of inflammatory cytokines in this disease.
authors.affiliation: Department of Medicine, Kusatsu Branch Hospital, Gunma University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Take
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: H
authors.initials: H
authors.lastname: Kurabayashi
authors.forename: T
authors.initials: T
authors.lastname: Shirakura
mesh_terms: D017668:Age of Onset; D000368:Aged; D001171:Arthritis, Juvenile / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D001310:Auranofin / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D011241:Prednisone / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D001310:Auranofin; D003520:Cyclophosphamide; D011241:Prednisone