Mutation position and type of substitution in the beta-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis.
Bodmer
T
T
Institute for Medical Microbiology, University of Berne, Switzerland.
Zürcher
G
G
Imboden
P
P
Telenti
A
A
D000995:Antitubercular Agents / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005798:Genes, Bacterial / Q000187:drug effects; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D010641:Phenotype; D017828:Rifabutin / Q000494:pharmacology*; D012293:Rifampin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014397:Tuberculosis, Pulmonary / Q000382:microbiology
D000995:Antitubercular Agents; D017828:Rifabutin; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin; C018421:rifapentine