Localization of the genes for the 100-kDa complement-activating components of Ra-reactive factor (CRARF and Crarf) to human 3q27-q28 and mouse 16B2-B3.
Human and mouse genes for the complement-activating component (P100) of Ra-reactive factor, a novel bactericidal factor (CRARF and Crarf), were mapped to R-banded metaphase chromosomes by fluorescence in situ hybridization with human and mouse P100 cDNA 2.7 and 2.0 kb long, respectively. The localization of fluorescent signals showed that CRARF and Crarf mapped to human 3q27-q28 and mouse 16B2-B3, respectively. This evidence is consistent with the previous assumption that the distal portion of the long arm of human chromosome 3 is homologous to the proximal portion of mouse chromosome 16.
Takada
F
F
Department of Molecular Biology, Kitasato University School of Medicine, Japan.
Seki
N
N
Matsuda
Y
Y
Takayama
Y
Y
Kawakami
M
M
D000818:Animals; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D003167:Complement Activation; D003175:Complement C2 / Q000276:immunology; D003181:Complement C4 / Q000276:immunology; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D050606:Mannose-Binding Protein-Associated Serine Proteases; D051379:Mice; D012697:Serine Endopeptidases / Q000235:genetics*
D003175:Complement C2; D003181:Complement C4; C084067:MASP1 protein, human; D050606:Mannose-Binding Protein-Associated Serine Proteases; D012697:Serine Endopeptidases