Ensuring safety and consistency in cell culture production processes: viral screening and inactivation.
The history of the use of biological products is littered with examples of the iatrogenic transmission of viruses. A major effort of the biotechnology industry is directed towards the elimination of any risk of infection from the products of cell culture. This article summarizes the overall strategy that has been followed, so far with great success, in that there have, as yet, been no reported cases of viral transmission by the products of biotechnology.
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National Institute for Biological Standards and Control, Potters Bar, Herts., UK.
D000818:Animals; D001688:Biological Products; D001709:Biotechnology; D002478:Cells, Cultured / Q000382:microbiology*; D006801:Humans; D012449:Safety; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000302:isolation & purification*
D001688:Biological Products