An investigation of HLA-encoded genetic susceptibility to multiple sclerosis in subjects of Asian Indian and Afro-Caribbean ethnic origin.
The association of multiple sclerosis (MS) with the HLA class II loci DR and DQ was investigated in populations of Asian Indian and Afro-Caribbean ethnic origin, resident in the United Kingdom. The putative haplotype, DRB1*1501.DQA1*0102.DQB1*0602, was weakly positively associated with MS in both races. The overall contribution to disease susceptibility of this marker was small. Over 80% of the MS patients in both racial groups did not possess this haplotype. The data suggest that other genetic and/or environmental factors may be more important in predisposing to MS in these two races. Our study also raises the possibility that genetically distinct forms of the disease may be expressed in white Caucasian and non-Caucasian populations.
Kelly
M A
MA
Department of Medicine, University of Birmingham, United Kingdom.
Jacobs
K H
KH
Penny
M A
MA
Mijovic
C H
CH
Nightingale
S
S
Barnett
A H
AH
Francis
D A
DA
D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D004247:DNA / Q000097:blood; D015343:DNA Probes, HLA; D005802:Genes, MHC Class II / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000145:classification / Q000235:genetics*; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D006801:Humans; D007194:India / Q000208:ethnology; D007563:Jamaica / Q000208:ethnology; D009103:Multiple Sclerosis / Q000208:ethnology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D006113:United Kingdom / Q000453:epidemiology; D044465:White People / Q000235:genetics
D015343:DNA Probes, HLA; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D004247:DNA