title: [The role of hereditary, clinical and pharmacokinetic factors in predicting the prophylactic effect of lithium salts].
abstract: In the framework of a multicentre WHO research program results of prophylactic treatment with lithium carbonate of 77 patients with affective phasic disorders were compared with a series of clinical parameters, specificity of lithium pharmacokinetics and the background characteristics of families in the groups of responders (68.8%) and non-responders. Correlations of efficacy with pharmacokinetic parameters were absent. Better preventive effect of lithium salts took place in male patients with disharmonic features of premorbid personality if their disease and prophylactic treatment started in young or in the middle age, if the disease was diagnosed as bipolar form of manic-depressive psychosis and attained its cyclothymic level with a periodical type of the prior phases. A significant accumulation of affective psychoses was found in the families of the responders. Possibility of prognostic significance of all the analyzed indices is discussed.
authors.forename: M E
authors.initials: ME
authors.lastname: Vartan'ian
authors.forename: G P
authors.initials: GP
authors.lastname: Panteleeva
authors.forename: V A
authors.initials: VA
authors.lastname: Gor'kov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Nikiforova
authors.forename: V A
authors.initials: VA
authors.lastname: Raiushkin
authors.forename: G I
authors.initials: GI
authors.lastname: Rozova
authors.forename: H
authors.initials: H
authors.lastname: Hippius
authors.forename: W
authors.initials: W
authors.lastname: Greil
authors.forename: F
authors.initials: F
authors.lastname: Catapano
authors.forename: M
authors.initials: M
authors.lastname: Maj
mesh_terms: D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000097:blood / Q000235:genetics / Q000517:prevention & control*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011618:Psychotic Disorders / Q000097:blood / Q000235:genetics / Q000517:prevention & control*; D012074:Remission Induction; D013997:Time Factors; D014944:World Health Organization
chemical_list: D016651:Lithium Carbonate
vernacular_title: Rol' nasledstvennykh, klinicheskikh i farmakokineticheskikh faktorov v prediktsii profilakticheskogo éffekta soleĭ litiia.