Quantitation, mobilization, and clinical use of long-term culture-initiating cells in blood cell autografts.
Mobilized peripheral blood is increasingly used as a source of cells to provide hematopoietic reconstitution in marrow ablated patients. There is controversy as to how the engraftment potential of these preparations should be evaluated. The long-term culture-initiating cell is a very primitive hematopoietic with unique phenotypic feature. The potential role and significance of these cells in peripheral blood cell autografts is discussed.
Sutherland
H J
HJ
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada.
Hogge
D E
DE
Lansdorp
P M
PM
Phillips
G L
GL
Eaves
A C
AC
Eaves
C J
CJ
D000818:Animals; D001773:Blood Cells / Q000637:transplantation*; D002454:Cell Differentiation; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D014182:Transplantation, Autologous