Structure-activity relationships of synthetic methyl ursolate glycosides.
From 15 synthetic methyl ursolate glycosides, the di- and tri-glycosides showed much higher haemolytic activity than the monoglycosides. The beta-gentiobioside and the beta-maltotrioside exhibited much stronger antibacterial (Staphylococcus aureus) or antifungal (Trichophyton mentagrophytes) activity than the other glycosides. However, none of them exhibited antibacterial activity against Bacillus subtilis.
Takechi
M
M
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.
Tanaka
Y
Y
D001419:Bacteria / Q000187:drug effects; D002240:Carbohydrate Sequence; D005658:Fungi / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006461:Hemolysis; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry*; D000097245:Ursolic Acid
D006027:Glycosides; D014315:Triterpenes; D000097245:Ursolic Acid