The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action.
Both the observed cis-inhibition and the proposed trans-activation of the insulin receptor tyrosine kinase help explain insulin signalling through its receptor.
McDonald
N Q
NQ
Department of Crystallography, Birkbeck College, London, UK.
Murray-Rust
J
J
Blundell
T L
TL
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008958:Models, Molecular; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011972:Receptor, Insulin / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology
D007328:Insulin; D011972:Receptor, Insulin