Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes.
Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero.
Demarini
S
S
Department of Pediatrics, University of Cincinnati Medical Center, OH 45267-0541, USA.
Specker
B L
BL
Sierra
R I
RI
Miodovnik
M
M
Tsang
R C
RC
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D015519:Bone Density; D001862:Bone Resorption / Q000097:blood*; D016022:Case-Control Studies; D003094:Collagen / Q000032:analysis; D024042:Collagen Type I; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005315:Fetal Diseases / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000032:analysis; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D011347:Procollagen / Q000097:blood; D011446:Prospective Studies
D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen