Anti-neutrophil cytoplasmic antibody for proteinase 3 in a child with polyarteritis nodosa.
We report a case of a 15 year old boy with polyarteritis nodosa associated with antineutrophil cytoplasmic antibody (ANCA) against proteinase 3 (PR3). After months of steroid and immunosuppressant therapy, the symptoms subsided and the polyaneurysms almost disappeared. The levels of anti-PR3 antibody and of cytokines also decreased. The results indicate that ANCA is a good indicator of this disease activity, and may play some pathogenic role in the disease.
Ito
Y
Y
Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
Nishi
A
A
Sakaguchi
M
M
Suzuki
Y
Y
Kaneko
K
K
Yasuoka
C
C
Tomita
S
S
Kato
H
H
D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D016207:Cytokines / Q000097:blood; D006801:Humans; D008297:Male; D053146:Myeloblastin; D010488:Polyarteritis Nodosa / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D012697:Serine Endopeptidases / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; D016207:Cytokines; D012697:Serine Endopeptidases; D053146:Myeloblastin