Strand scission in DNA induced by L-DOPA in the presence of Cu(II).
It has been recently reported that L-DOPA and Cu(II) in the presence of H2O2 leads to extensive DNA damage. In this paper we show that L-DOPA in the presence of Cu(II) alone can cause DNA cleavage through the generation of reactive oxygen species such as the hydroxyl radical. Fluorescence quenching studies indicate that L-DOPA is capable of binding to DNA.
Husain
S
S
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
Hadi
S M
SM
D000818:Animals; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage; D006861:Hydrogen Peroxide / Q000737:chemistry*; D017665:Hydroxyl Radical; D007980:Levodopa / Q000737:chemistry* / Q000378:metabolism; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D017382:Reactive Oxygen Species; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000378:metabolism; D013050:Spectrometry, Fluorescence
D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical; D007980:Levodopa; D003300:Copper; D004247:DNA; D006861:Hydrogen Peroxide; D015719:Single-Strand Specific DNA and RNA Endonucleases