title: Safety of ototopical antibiotics.
abstract: A prospective randomized study analyzing the safety and efficacy of a single dose of ototopical antibiotics following human middle ear tympanostomy tube insertion was performed. Fifty children undergoing bilateral tympanostomy tube insertion were studied by the placement of 0.5 mL of Cortisporin Otic Suspension (COS; Burroughs Wellcome Co., Research Triangle Park, N.C.) to one middle ear space by random assignment. Preoperative and postoperative audiograms were obtained, and the presence of otorrhea was noted. In one patient sensorineural hearing loss of 6 dB developed bilaterally, which was symmetric in both the treated and the untreated ear. This preliminary study showed no statistical difference in hearing loss or postoperative otorrhea associated with a single application of Cortisporin to the middle ear space.
authors.affiliation: Department of Otolaryngology, Ohio State University, Columbus, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Welling
authors.forename: L A
authors.initials: LA
authors.lastname: Forrest
authors.forename: F
authors.initials: F
authors.lastname: Goll
mesh_terms: D000287:Administration, Topical; D001299:Audiometry; D002648:Child; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D008876:Middle Ear Ventilation; D009355:Neomycin / Q000008:administration & dosage* / Q000009:adverse effects*; D010033:Otitis Media / Q000188:drug therapy* / Q000601:surgery; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000601:surgery; D011112:Polymyxin B / Q000008:administration & dosage* / Q000009:adverse effects*; D011446:Prospective Studies
chemical_list: D004338:Drug Combinations; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone