title: Synthesis and pharmacological properties of derivatives of isoxazolo[4,3-d]pyrimidine. III.
abstract: Synthesis of new isoxazolo[4,5-d]pyrimidine derivatives is reported. Some of isoxazolo[4,5-d]pyrimidine derivatives were tested for anticonvulsant, anxiolytic and antiserotonine activity. Compounds 14 and 16 proved active against hypothermia induced by reserpine and hyperthermia induced by m-CPP.
authors.affiliation: Department of Technology of Drugs, Wroclaw University of Medicine, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Wagner
authors.forename: K
authors.initials: K
authors.lastname: Poreba
authors.forename: I
authors.initials: I
authors.lastname: Jakowicz
authors.forename: D
authors.initials: D
authors.lastname: Balicka
authors.forename: M
authors.initials: M
authors.lastname: Rutkowska
authors.forename: L
authors.initials: L
authors.lastname: Kedzierska-Goździk
authors.forename: A
authors.initials: A
authors.lastname: Szelag
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D004597:Electroshock; D005260:Female; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010879:Piperazines / Q000037:antagonists & inhibitors; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D007555:Isoxazoles; D010879:Piperazines; D011619:Psychotropic Drugs; D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; D012110:Reserpine; C015068:1-(3-chlorophenyl)piperazine; D010433:Pentylenetetrazole