Killing and mutation of Chinese hamster V79 cells exposed to accelerated oxygen and neon ions.
Mutation induction by accelerated heavy ions to 6-thioguanine resistance (HPRT system) in Chinese hamster V79 cells was investigated using oxygen and neon ions with energies between 1.9 and 400 MeV/mu, corresponding to LET values between 18 and 754 keV/microns, respectively. Because of technical limitations most experiments could be performed only once. Inactivation and mutation induction cross sections, sigma i and sigma m, were obtained from the slopes of the exponential survival and the linear mutation induction curves, respectively. Both parameters increased with LET up to about 200 keV/microns, where the curves separated for the two types of ions. Calculated RBEs were higher for mutation induction than for killing for all LET values.
Stoll
U
U
Strahlenzentrum, Justus-Liebig-Universität, Abtellung Zell- and Strahlenbiophysik, Giessen, Germany.
Schmidt
A
A
Schneider
E
E
Kiefer
J
J
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D004351:Drug Resistance; D018499:Linear Energy Transfer; D008168:Lung; D016296:Mutagenesis / Q000187:drug effects / Q000528:radiation effects*; D009356:Neon; D010100:Oxygen; D013866:Thioguanine / Q000633:toxicity
D009356:Neon; D013866:Thioguanine; D010100:Oxygen