[The effect of a number of pharmacological preparations on Na-H metabolic activity and on the passive permeability for protons of the sarcolemma of the isolated heart].
The influence of the local anesthetics hydrocortisone hemisuccinate and peptide drugs (thymogen and dalargin) on Na-H exchange activity and passive proton permeability of the sarcolemma was studied in experiments on isolated rat hearts. It was established that neither local anesthetics or hydrocortisone hemisuccinate, nor peptide drugs affected Na-H exchange activity. Lidocaine (5 mM), procaine (5 mM), hydrocortisone hemisuccinate (500-750 mg/l) inhibited sarcolemmal passive proton permeability by 40-70%. Aetaphone in the micromolar range attenuated the role of these effects in the antiarrhythmic action of local anesthetics and aetaphone.
Alabovskiĭ
V V
VV
Nikolaevskiĭ
V A
VA
Reznikov
K M
KM
Vinokurova
O V
OV
Putilina
V V
VV
Vinokurov
A A
AA
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D006859:Hydrogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion / Q000379:methods; D011522:Protons; D051381:Rats; D012508:Sarcolemma / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D013997:Time Factors
D011522:Protons; D006859:Hydrogen; D012964:Sodium
Vliianie riada farmakologicheskikh preparatov na aktivnost' Na--H-obmena i passivnuiu pronitsaemost' sarkolemmy izolirobvannogo serdtsa dlia protonov.