Designing a molecular probe for muscarinic acetylcholine receptor (mAChR) imaging.
Radiolabeled molecular probes have demonstrated the potential for in vivo quantification of cell surface receptor concentration as a function of disease. Molecular biology has been instrumental in the design of these probes for in vivo studies, as exemplified by a molecular probe for muscarinic acetylcholine (mACh) receptor imaging. On a technical level, molecular biology has led to a better understanding of the selectivity of a radiolabeled probe in vitro. On a physiologic level, a combination of molecular biology and nuclear medicine provides an opportunity to validate in vivo what has been learned about receptors in vitro.
Eckelman
W C
WC
PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
D000818:Animals; D006801:Humans; D007457:Iodine Radioisotopes; D015335:Molecular Probes; D011813:Quinuclidinyl Benzilate / Q000031:analogs & derivatives; D011976:Receptors, Muscarinic / Q000032:analysis*
D007457:Iodine Radioisotopes; D015335:Molecular Probes; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; C040062:3-quinuclidinyl-4-iodobenzilate