Apolipoprotein E in alcoholics.
In 31 alcohol addicted patients entering detoxication treatment and in 14 social drinkers apolipoprotein E (Apo E) was assayed by radial immunodiffusion in the whole serum and after phosphotungstate Mg2+ precipitation. Serum Apo E level in the intoxicated individuals was increased compared with the controls. The Apo E increase was mostly due to the very low and low density (VLDL + LDL) fraction. The Apo E/cholesterol ratio in this fraction was increased. It is possible that increased Apo E concentration in VLDL contributes to their enhanced uptake by the liver.
Wehr
H
H
Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland.
Bednarska-Makaruk
M
M
Szacka
E
E
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood* / Q000628:therapy; D001057:Apolipoproteins E / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008658:Inactivation, Metabolic; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged
D001057:Apolipoproteins E; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D002784:Cholesterol