title: Metabolism of the polycyclic aromatic hydrocarbon pyrene by Aspergillus niger SK 9317.
abstract: The metabolism of pyrene, a polycyclic aromatic hydrocarbon consisting of four rings, by Aspergillus niger SK 9317 was investigated. The metabolites formed were isolated and identified as 1-hydroxypyrene, 1,6- and 1,8-pyrenequinone, 1,6- and 1,8-dihydroxypyrene, 1-pyrenyl sulphate and 1-hydroxy-8-pyrenyl sulphate. This is the first report of 1-hydroxy-8-pyrenyl as a metabolite in the microbial metabolism of pyrene. The results suggest that A. niger metabolizes pyrene by cytochrome P-450 monooxygenase enzyme systems.
authors.affiliation: University of Kaiserslautern, Department of Biotechnology, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Wunder
authors.forename: S
authors.initials: S
authors.lastname: Kremer
authors.forename: O
authors.initials: O
authors.lastname: Sterner
authors.forename: H
authors.initials: H
authors.lastname: Anke
mesh_terms: D001234:Aspergillus niger / Q000378:metabolism*; D001673:Biodegradation, Environmental; D001709:Biotechnology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004785:Environmental Pollutants / Q000378:metabolism; D005285:Fermentation; D006900:Hydroxylation; D008956:Models, Chemical; D015394:Molecular Structure; D010105:Oxygenases / Q000378:metabolism; D011721:Pyrenes / Q000737:chemistry / Q000378:metabolism*; D011809:Quinones / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism
chemical_list: D004785:Environmental Pollutants; D011721:Pyrenes; D011809:Quinones; D013431:Sulfates; D003577:Cytochrome P-450 Enzyme System; C030984:pyrene; D010105:Oxygenases