[Correction of lipid peroxidation intensity and glutathione system by derivatives of polygalacturonic acid after exposure to nitrogen dioxide].
Influence of intraperitoneal administration of polygalacturonic acid derivatives at a dose of 100 mg/kg on the glutathione system and lipid peroxidation in the rat lung after treatment with NO2 was studied. A considerable decrease of lipid peroxidation intensity by these derivatives was caused not only by ability of these compounds to the chelate formation and absorption of free radicals, but also by the substantial activation of the glutathione system.
Galkin
B N
BN
Ostrov
V E
VE
Golovenko
N Ia
NIa
Bondar'
S N
SN
Barinov
V A
VA
Tiunov
L A
LA
Dilippova
T O
TO
Chernienko
I E
IE
D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010368:Pectins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
D010368:Pectins; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; D009585:Nitrogen Dioxide; C003181:polygalacturonic acid
Korrektsiia proizvodnymi poligalakturonovoĭ kisloty intensivnosti perekisnogo okisleniia lipidov i sistemy glutationa pri vozdeĭstvii dioksida azota.