title: Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia.
abstract: S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.
authors.affiliation: Department of Biochemistry, Sct. Hans Hospital, Roskilde, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Andersson
authors.forename: O
authors.initials: O
authors.lastname: Bergendorff
authors.forename: M
authors.initials: M
authors.lastname: Nielsen
authors.forename: O
authors.initials: O
authors.lastname: Sterner
authors.forename: R
authors.initials: R
authors.lastname: Witt
authors.forename: J
authors.initials: J
authors.lastname: Ai
authors.forename: A
authors.initials: A
authors.lastname: Lu
authors.forename: A M
authors.initials: AM
authors.lastname: Wang
mesh_terms: D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007608:Kainic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism*
chemical_list: D004365:Drugs, Chinese Herbal; D017470:Receptors, Glutamate; D007608:Kainic Acid