title: Improved techniques for immortalizing animal cells.
abstract: The use of cultured mammalian cells for assessing potential new drugs and for basic biological research is increasing, since it facilitates the large-scale screening of candidate drugs and reduces the need for animal experimentation. In this review, the technology and tools required for producing cell lines of interest are described, and possible areas of research that will enhance the application of this rapidly expanding area of biotechnology are discussed.
authors.affiliation: ZENECA Pharmaceuticals, Alderley Park, Cheshire, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: McLean
mesh_terms: D000818:Animals; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003584:Cytological Techniques; D009857:Oncogenes