Analysis of cystic fibrosis referrals for lung transplantation.
Patients with cystic fibrosis (CF) are being considered in increasing numbers as candidates for lung transplantation, despite earlier concerns that their nutritional status and the infective nature of their lung disease would contribute to increased morbidity and mortality. We undertook a retrospective analysis of patients with CF referred for consideration of lung transplant to identify factors that helped to select suitable transplant candidates and to identify characteristics that predicted death while on the waiting list. Analysis of 95 referred patients with CF demonstrated a high rate of suitability (78%) by our criteria. The mean weight of listed patients with CF was 77% predicted, and the mean FEV1 was 20% predicted. Sixteen percent of listed patients with CF died awaiting transplant. The FEV1 of these patients was significantly lower than that of patients who survived to transplant. This study implies that patients with CF are being referred for transplant late in the course of their disease. Earlier referral may lead to an increase in the number of patients with CF undergoing successful lung transplantation.
Ciriaco
P
P
Division of Cardiothoracic Surgery, University of North Carolina School of Medicine, Chapel Hill, USA.
Egan
T M
TM
Cairns
E L
EL
Thompson
J T
JT
Detterbeck
F C
FC
Paradowski
L J
LJ
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000704:Analysis of Variance; D002648:Child; D000075202:Contraindications; D003550:Cystic Fibrosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016040:Lung Transplantation / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012189:Retrospective Studies