Accessing three-dimensional chemical information in antibody molecules.
Important structural information can be obtained from monoclonal antibodies through X-ray crystallographic analysis and computer modeling of CDR loops. These applications of monoclonal antibody technology offer new insights and novel approaches to the modification of antibody molecules for disease treatment, diagnosis, and drug design.
Skaletsky
E
E
Research Products and Services, ImmunoPharmaceutics, Inc., San Diego, CA 92127.
Ramnarayan
K
K
D000911:Antibodies, Monoclonal / Q000737:chemistry*; D003461:Crystallography; D015195:Drug Design; D008958:Models, Molecular
D000911:Antibodies, Monoclonal