[Ultrastructural immunocytochemical study of lymphocyte subsets from patients with systemic lupus erythematosus and bearing tubuloreticular inclusions].
The tubuloreticular inclusions (TRI) correspond to a modification of the endoplasmic reticulum, observed in different pathological conditions, the most frequent being immune disorders. In the systemic lupus erythematosus, they are present in 2.7% to 4.4% of circulating lymphocytes in 4 patients out of 5. Using an immunogold technique, the TRI were identified only in the T lymphocytes (26/331 T lymphocytes versus 0/79 B lymphocytes, p < 0.01 Chi square) and more precisely in the T4 "Helpers" (16/218 T4 versus 0/123 T8, p < 0.01 Chi square).
Wagner
M
M
Institut de Pathologie, Strasbourg.
Vetter
J M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000473:pathology*; D016131:Lymphocyte Subsets / Q000648:ultrastructure*; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged
Etude immunocytochimique ultrastructurale des sous-populations lymphocytaires de patients atteints de lupus erythémateux systémique et renfermant des inclusions tubulo-réticulaires.