Synthesis and pharmacological properties of derivatives of isoxazolo[4,3-d]pyrimidine. III.
Synthesis of new isoxazolo[4,5-d]pyrimidine derivatives is reported. Some of isoxazolo[4,5-d]pyrimidine derivatives were tested for anticonvulsant, anxiolytic and antiserotonine activity. Compounds 14 and 16 proved active against hypothermia induced by reserpine and hyperthermia induced by m-CPP.
Wagner
E
E
Department of Technology of Drugs, Wroclaw University of Medicine, Poland.
Poreba
K
K
Jakowicz
I
I
Balicka
D
D
Rutkowska
M
M
Kedzierska-Goździk
L
L
Szelag
A
A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D004597:Electroshock; D005260:Female; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010879:Piperazines / Q000037:antagonists & inhibitors; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D007555:Isoxazoles; D010879:Piperazines; D011619:Psychotropic Drugs; D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; D012110:Reserpine; C015068:1-(3-chlorophenyl)piperazine; D010433:Pentylenetetrazole