Does intravenous glutamine prevent bacterial translocation in hemorrhagic shock?
Bacterial translocation across the gut wall may be associated with insult to the latter. In this situation, intestinal flora can enter the blood stream and lymph nodes and be transported to other organs. Glutamine is a nonessential amino acid not presently included in total parenteral nutrition (TPN) preparations. The use of glutamine-enriched TPN in the rat has resulted in a significant reduction in bacterial translocation. This study attempted to evaluate the role of glutamine in preventing bacterial translocation following hemorrhagic shock in a rat model. Forty Sprague-Dawley rats were equally divided into two groups. The controls were given TPN solution, while the treated group had glutamine instead of the standard alanine present in TPN. Hemorrhagic shock was induced in both groups and blood cultures were performed. Glutamine-treated rats did not show a significant difference in survival suggesting that it is of no particular value in severe hemorrhagic shock in rats.
Premaratne
S
S
Department of Surgery, University of Hawaii at Manoa, Queen's Medical Center, Honolulu 96813, USA.
Masuda
E
E
Nishida
S
S
Suehiro
A
A
McNamara
J J
JJ
D000409:Alanine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001769:Blood / Q000382:microbiology; D005973:Glutamine / Q000008:administration & dosage / Q000494:pharmacology*; D007261:Infusions, Intra-Arterial; D007422:Intestines / Q000382:microbiology*; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D010289:Parenteral Nutrition, Total; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000382:microbiology / Q000503:physiopathology* / Q000628:therapy
D005973:Glutamine; D000409:Alanine