title: Ras signaling and NF1.
abstract: The gene responsible for the hereditary disease neurofibromatosis type 1 (NF1) has been well characterized as a regulator of Ras protein activity. Many aspects of the disease seem to be caused by misregulation of Ras as a result of NF1 mutation. Other aspects, however, point at functions for the NF1 protein that have yet to be discovered.
authors.affiliation: Onyx Pharmaceuticals, Richmond, California 94806, USA.
authors.forename: F
authors.initials: F
authors.lastname: McCormick
mesh_terms: D000818:Animals; D016514:Genes, Neurofibromatosis 1; D006801:Humans; D008954:Models, Biological; D009456:Neurofibromatosis 1 / Q000235:genetics; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D018631:ras Proteins