title: Normal HBsAg presentation and T-cell defect in the immune response of nonresponders.
abstract: Lymphocytes from nonresponders to HBsAg fail to proliferate in vitro in the presence of HBsAg-pulsed antigen presenting cells. We studied four pairs of major histocompatibility complex (MHC)-matched, mixed lymphocyte reaction-negative individuals discordant for HBsAg response. For each pair, responder lymphocytes proliferated in the presence of nonresponder antigen-pulsed antigen presenting cells. Responder and nonresponder antigen presenting cells were equally effective. There was no evidence for inhibition of responder T-cell proliferation by nonresponder lymphocytes or antigen presenting cells. The defect is thus in the helper T cells of nonresponders and not in the antigen processing or binding of processed peptides to MHC molecules on antigen presenting cells.
authors.affiliation: Harvard Medical School, Boston, MA 02115, USA.
authors.forename: M
authors.initials: M
authors.lastname: Salazar
authors.forename: H
authors.initials: H
authors.lastname: Deulofeut
authors.forename: C
authors.initials: C
authors.lastname: Granja
authors.forename: R
authors.initials: R
authors.lastname: Deulofeut
authors.forename: D E
authors.initials: DE
authors.lastname: Yunis
authors.forename: D
authors.initials: D
authors.lastname: Marcus-Bagley
authors.forename: Z
authors.initials: Z
authors.lastname: Awdeh
authors.forename: C A
authors.initials: CA
authors.lastname: Alper
authors.forename: E J
authors.initials: EJ
authors.lastname: Yunis
mesh_terms: D000328:Adult; D000938:Antigen-Presenting Cells / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic