Perinatal factors and 2-year minor neurodevelopmental impairment in low birth weight infants.
Perinatal factors were investigated in 53 low birth weight infants with minor neurodevelopmental dysfunction at 2-year follow-up and in 106 consecutive controls matched for gestational age and birth weight (within 100-gram intervals). The obstetrical history, as evaluated by the obstetrical optimality score, was significantly worse in the cases than in controls (obstetrical optimality score = 50.9 +/- 5.9 vs. 53.2 +/- 6.9, p = 0.019 by Mann-Whitney test). Multiple conditional logistic regression analysis showed that after adjustment for socioeconomic status and education of the mother, a low number (< 3) of prenatal visits, and a third trimester hemorrhage were the only antenatal factors significantly associated with an increased risk of minor infant neurodevelopmental impairment. Neonatal acidosis (pH < 7.2 in the first 24 h of life) and male gender were additional significant perinatal risk factors. Only a few antenatal and perinatal factors are correlated with subsequent minor neurodevelopmental impairment in low birth weight infants.
Spinillo
A
A
Department of Obstetrics and Gynecology, Pavia University, Italy.
Fazzi
E
E
Orcesi
S
S
Accorsi
P
P
Beccaria
F
F
Capuzzo
E
E
D000138:Acidosis / Q000378:metabolism / Q000503:physiopathology; D000328:Adult; D001724:Birth Weight; D001921:Brain / Q000254:growth & development*; D002657:Child Development / Q000502:physiology*; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007230:Infant, Low Birth Weight / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000453:epidemiology; D008297:Male; D009035:Mothers; D012044:Regression Analysis; D012307:Risk Factors; D012923:Social Class