The repression of listeriolysin O expression in Listeria monocytogenes by the phenolic beta-D-glucoside, arbutin.
Expression of the listeriolysin O, a key virulence factor for Listeria monocytogenes, was monitored using a hlyA-luxAB transcriptional fusion. The phenolic beta-D-glucoside, arbutin, was found to repress the expression of the listeriolysin O at the level of transcription. In contrast, the structurally similar beta-glucoside salicin did not prevent expression of listeriolysin.
Park
S F
SF
AFRC Institute of Food Research, Reading Laboratory, UK.
D001104:Arbutin / Q000494:pharmacology*; D001427:Bacterial Toxins; D004794:Enzyme Repression; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics*; D006460:Hemolysin Proteins; D008089:Listeria monocytogenes / Q000201:enzymology*
D001427:Bacterial Toxins; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D001104:Arbutin; C038705:hlyA protein, Listeria monocytogenes