title: Antimicrobial isoflavans from Astragalus species.
abstract: Two new antimicrobial isoflavans, 1-[(3R)-7,8-dimethoxybenzopyranyl]-4- hydroxybenzoquinone (astragaluquinone) and (3S)-7,1'-dihydroxy-8,3'-dimethoxyisoflavan (8-methoxyvestitol), and the known 7-hydroxy-2',3',4'-trimethoxyisoflavan were isolated from roots of Astragalus alexandrinus and A. trigonus. The structures of the new isoflavans were established by spectroscopic methods.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Egypt.
authors.forename: N A
authors.initials: NA
authors.lastname: el-Sebakhy
authors.forename: A M
authors.initials: AM
authors.lastname: Asaad
authors.forename: R M
authors.initials: RM
authors.lastname: Abdallah
authors.forename: S M
authors.initials: SM
authors.lastname: Toaima
authors.forename: M S
authors.initials: MS
authors.lastname: Abdel-Kader
authors.forename: F R
authors.initials: FR
authors.lastname: Stermitz
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology*; D016227:Benzoquinones; D002176:Candida albicans / Q000187:drug effects; D002240:Carbohydrate Sequence; D007529:Isoflavones; D007711:Klebsiella pneumoniae / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C090263:8-methoxyvestitol; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001578:Benzopyrans; D016227:Benzoquinones; D007529:Isoflavones; D011809:Quinones; C090261:astragaluquinone