[Activation and free radical formation of leukocytes in patients with acute ischemic stroke].
The leukocyte count, leukocyte activation, lipoperoxidant (Lpo) of leukocytes and C3 in the peripheral blood were determined in 44 patients with acute ischemic stroke and the results were compared with those in age-matched healthy controls. No significant difference in mean leukocyte counts was observed between the patients and controls. The levels of leukocyte activation in the patients were significantly higher than those in the controls (137.94 +/- 38.86 U/L vs 92.22 +/- 20.29 U/L, P < 0.01), while the levels of Lpo of leukocytes and C3 were significantly lower than those in the controls (0.90 +/- 0.87 mumol/L and 0.96 +/- 0.72 g/L vs 1.57 +/- 1.29 mumol/L and 1.69 +/- 0.70 g/L, P < 0.01). The changes of these levels were in correlation with the extent of cerebral infarction. It is suggested that leukocytes might be involved in the pathophysiological process of acute ischemic brain damage. Its mechanisms and route of activation were discussed briefly.
Xu
Y B
YB
Huzhou Second Municipal Hospital, Zhejiang.
Zhu
J S
JS
Zhang
G P
GP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000097:blood* / Q000276:immunology; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D018375:Neutrophil Activation
D003176:Complement C3; D005609:Free Radicals; D008054:Lipid Peroxides