[Hyperthyroidism and osteoporosis].
Iodine-containing thyroid hormones lead to global stimulation of bone remodelling and increase the birth of multicellular units which harbour the osteoclast resorption-osteoblast formation sequence. Thus, hyperthyroidism accelerates trabecular, and especially cortical, bone loss. It is not rare to discover unrecognized hyperthyroidism in patients with wedge fractures of the vertebrae which were thought to be the result of common post-menopause osteoporosis. Measuring the level of biochemical markers of bone remodelling (serum osteocalcin, urinary pyridinoline and hydroxyproline) can also give evidence of stimulated bone remodelling in patients with hyperthyroidism. Densitometric studies show a significant though moderate reduction in lumbar and femoral bone density in hyperthyroidism. Bone loss is greater in the radius.
Meunier
P J
PJ
Service de Rhumatologie et de Pathologie Osseuse, Unité INSERM 403, Hôpital Edouard Herriot, Lyon.
D000328:Adult; D015519:Bone Density; D001861:Bone Regeneration; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000378:metabolism; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000378:metabolism*
D002118:Calcium
Hyperthyroïdies et ostéoporose.