Bactericidal effect of rat cystatin S on an oral bacterium Porphyromonas gingivalis.
We tested antibacterial and antiviral activities of rat cystatin S, a cysteine proteinase inhibitor, belonging to the family 2 cystatins against 18 different bacterial species and poliovirus type 1 (Sabin). Rat cystatin S specifically inhibited the growth of a human oral anaerobic bacterium Porphyromonas gingivalis due to a bactericidal effect.
Naito
Y
Y
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Sasaki
M
M
Umemoto
T
T
Namikawa
I
I
Sakae
K
K
Ishihara
Y
Y
Isomura
S
S
Suzuki
I
I
D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D015891:Cystatins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D017955:Poliovirus / Q000187:drug effects; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D021382:Protein Sorting Signals / Q000737:chemistry / Q000235:genetics; D051381:Rats; D055333:Salivary Cystatins; D013045:Species Specificity; D013297:Streptococcus pyogenes / Q000187:drug effects
C525173:CST4 protein, human; C525174:Cyss protein, rat; D015891:Cystatins; D015853:Cysteine Proteinase Inhibitors; D021382:Protein Sorting Signals; D055333:Salivary Cystatins