title: The role of lipoprotein A-I and lipoprotein A-I/A-II in predicting coronary artery disease.
abstract: The aim of this study was to examine the role of HDL subparticles with apolipoprotein (apo) A-I alone (LpA-I) and with apoA-I and apoA-II (LpA-I/A-II) in predicting coronary artery disease. Concentrations of these HDL subparticles were compared in 184 subjects with angiographically confirmed significant coronary artery disease (> 50% stenosis of at least one vessel) and 191 age- and sex-matched control subjects without clinical coronary artery disease. LpA-I and LpA-I/A-II were measured with magnetic beads coated with anti-apoA-II antibodies to separate particles containing apoA-II from plasma. Total plasma cholesterol and triglyceride levels were similar in both groups. Although subjects with coronary artery disease had lower HDL cholesterol, plasma apoA-I, LpA-I, and LpA-I/A-II than age- and sex-matched control subjects without coronary artery disease, plasma apoA-I was the best predictor of coronary artery disease. In conclusion, LpA-I and LpA-I/A-II are lower in subjects with coronary artery disease but do not add to plasma apoA-I in predicting the presence of coronary artery disease.
authors.affiliation: Atherosclerosis Research Unit, Mayo Clinic and Foundation, Rochester, Minn., USA.
authors.forename: T
authors.initials: T
authors.lastname: O'Brien
authors.forename: T T
authors.initials: TT
authors.lastname: Nguyen
authors.forename: B J
authors.initials: BJ
authors.lastname: Hallaway
authors.forename: D
authors.initials: D
authors.lastname: Hodge
authors.forename: K
authors.initials: K
authors.lastname: Bailey
authors.forename: D
authors.initials: D
authors.lastname: Holmes
authors.forename: B A
authors.initials: BA
authors.lastname: Kottke
mesh_terms: D000368:Aged; D000792:Angiography; D016633:Apolipoprotein A-II / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000175:diagnosis*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000031:analogs & derivatives* / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D016633:Apolipoprotein A-II; D015415:Biomarkers; D017270:Lipoprotein(a); D008075:Lipoproteins, HDL; C078260:lipoprotein A-I