title: Human interferon-beta therapy for cerebral primitive neuroectodermal tumors--two case reports.
abstract: A 5-year-old girl and a 2-year-old boy presented with recurrent cerebral primitive neuroectodermal tumor (PNET) and were treated with intravenous administration of human fibroblast interferon (HuIFN-beta) which was continued as outpatient maintenance therapy. Both patients showed a partial response and were still alive 14 months and 2 years after diagnosis. Our results suggest that HuIFN-beta is an effective therapy for PNET, and can be used as long-term maintenance therapy without serious side effects.
authors.affiliation: Department of Neurosurgery, Ichihara Hospital, Teikyo University School of Medicine, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Hirakawa
authors.forename: S
authors.initials: S
authors.lastname: Manaka
authors.forename: T
authors.initials: T
authors.lastname: Nagashima
mesh_terms: D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D016899:Interferon-beta / Q000008:administration & dosage*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*
chemical_list: D016899:Interferon-beta