[Cytochrome p450 IID6, its role in psychopharmacology].
Cytochrome P450 IID6 has got typical features (genetical polymorphism, competitive inhibition, saturability) which can be at the origin of pharmacokinetic modifications of molecules using it for their metabolism. In the field of pharmacology, many molecules are substrates or inhibitors of this cytochrome. They are presented. The results of a study of the dextromethorphan variation test performed before and after 28 days of clomipramine therapy with depressed patients are explained. They show a significant decreasing of the cytochrome P450 IID6 oxidation capacities between both of these times. A patient has passed from the phenotype "effective metabolizer" to the one of "poor metabolizer" with clomipramine.
Lamard
L
L
C.H.S.V., Poitiers.
Pérault
M C
MC
Bouquet
S
S
Guibert
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002997:Clomipramine / Q000494:pharmacology*; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D003915:Dextromethorphan / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D011569:Psychiatric Status Rating Scales
D003915:Dextromethorphan; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D002997:Clomipramine
Le cytochrome P450 IID6, son rôle en psychopharmacologie.