Charge-transfer chromatographic study of the complex formation of some anticancer drugs with gamma-cyclodextrin.
The interaction between 23 anticancer drugs and gamma-cyclodextrin (gamma-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. gamma-CD formed inclusion complexes with 14 compounds, the complex always being more or less hydrophobic than the uncomplexed drug. The inclusion-forming capacity of a drug differed considerably depending on its chemical structure. The linear correlation between the hydrophobicity and the specific hydrophobic surface area of anticancer drugs indicated that they can be considered a homologous series of compounds, although their chemical structures are highly different.
Cserháti
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Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D016190:Carboplatin / Q000737:chemistry / Q000494:pharmacology; D002845:Chromatography / Q000379:methods; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism; D008698:Mesylates / Q000737:chemistry / Q000494:pharmacology; D008927:Mitobronitol / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D047408:gamma-Cyclodextrins
D000970:Antineoplastic Agents; D003505:Cyclodextrins; D008698:Mesylates; D047408:gamma-Cyclodextrins; C100121:mannosulfan; D008927:Mitobronitol; D016190:Carboplatin; C023792:gamma-cyclodextrin