title: [Systemic infection due to group A Streptococcus pyogenes].
abstract: A 47-year-old woman developed oedematous swelling of the skin over the left hip and leg, with joint pains and reddening over joints of the hands and left ankle. 2 months before her son had had scarlet fever, following which the patient had two episodes of fever. Shortly before hospitalization she was treated with a glucocorticoid because a rheumatic disease had been suspected. On admission the blood sedimentation rate was 58/90, the white cell count was 15.100/microliters with left shift in the differential count. The swellings in arms and legs became abscesses which were incised. An abscess over the left buttock, diagnosed by 67-gallium whole-body scintigraphy, was also treated surgically. On the day of admission penicillin (10 mill. IU three times daily intravenously) and, from the 4th day onwards, gentamicin (80 mg three times daily intravenously) were administered. Histological examination of fascia and muscle biopsies revealed nonspecific inflammation without signs of malignancy, white blood culture grew group A Streptococcus pyogenes. 20 days after the surgical intervention the patient was discharged in full health. Necrotizing fasciitis caused by Streptococcus pyogenes has become more frequent in the last few years and has often been accompanied by severe systemic complications.
authors.affiliation: Medizinische Klinik I, Universitätsklinikums Frankfurt.
authors.forename: T S
authors.initials: TS
authors.lastname: Pohl
authors.forename: P M
authors.initials: PM
authors.lastname: Shah
authors.forename: A
authors.initials: A
authors.lastname: Hertel
authors.forename: S
authors.initials: S
authors.lastname: Adams
authors.forename: U
authors.initials: U
authors.lastname: Koch
authors.forename: H C
authors.initials: HC
authors.lastname: Wenisch
authors.forename: G
authors.initials: G
authors.lastname: Hör
authors.forename: K H
authors.initials: KH
authors.lastname: Usadel
mesh_terms: D005208:Fasciitis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005710:Gallium Radioisotopes; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D009336:Necrosis; D010406:Penicillins / Q000008:administration & dosage; D011877:Radionuclide Imaging; D013290:Streptococcal Infections / Q000000981:diagnostic imaging / Q000188:drug therapy; D013297:Streptococcus pyogenes; D013997:Time Factors
chemical_list: D005710:Gallium Radioisotopes; D005839:Gentamicins; D010406:Penicillins
vernacular_title: Systemische Infektion mit Streptococcus pyogenes der Gruppe A.