Adenosine mediates the effects of ethanol on the cAMP signal transduction system.
Acute exposure to ethanol causes increased cAMP production whereas chronic exposure results in heterologous desensitization. These changes are due to accumulation of extracellular adenosine resulting from inhibition of adenosine uptake into cells.
Gordon
A S
AS
Department of Neurology, University of California, San Francisco 94110, USA.
Diamond
I
I
D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D018047:Receptors, Purinergic P1 / Q000187:drug effects / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D018047:Receptors, Purinergic P1; D000431:Ethanol; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D000241:Adenosine