title: Synthesis of both the enantiomers of aseanostatin P5 (sarcinic acid), an inhibitor of myeloperoxidase release, and four diastereomers of aggreceride A, a platelet aggregation inhibitor.
abstract: Both the enantiomers of aseanostatin P5 (sarcinic acid), an inhibitor of myeloperoxidase (MPO) release from human polymorphonuclear leukocytes (PMN), with high optical purity were synthesized by starting from (S)-2-methylbutanol and methyl (S)-3-hydroxy-2-methylpropanoate. They were converted to four diastereomers of aggreceride A, a platelet aggregation inhibitor.
authors.affiliation: Department of Applied Biological Chemistry, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kitahara
authors.forename: S
authors.initials: S
authors.lastname: Aono
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D005227:Fatty Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005989:Glycerides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009195:Peroxidase / Q000037:antagonists & inhibitors*; D010974:Platelet Aggregation / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D005227:Fatty Acids; D005989:Glycerides; C049993:aggreceride A; C069642:aseanostatin P5; D009195:Peroxidase