Antioxidant activity of depsides and depsidones.
The antioxidant activity of lichenic metabolites, depsides and depsidones, was assessed by their effects as inhibitors of rat brain homogenate auto-oxidation and beta-carotene oxidation. The results obtained in both systems indicate that lichenic metabolites afford a moderate protection in the microM concentration range. The largest effect was measured employing 1'-chloropannarin in the brain homogenate auto-oxidation, where a 66% protection was afforded at 1.7 microM. This protection is very similar to that elicited by addition of the reference antioxidant propylgallate (70% protection at 1.3 microM).
Hidalgo
M E
ME
Escuela de Química y Farmacia, Facultad de Medicina, Universidad de Valparaíso, Chile.
Fernández
E
E
Quilhot
W
W
Lissi
E
E
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002338:Carotenoids / Q000378:metabolism; D053630:Depsides; D062385:Hydroxybenzoates / Q000494:pharmacology*; D007783:Lactones / Q000494:pharmacology*; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D051381:Rats; D019207:beta Carotene
D000975:Antioxidants; D053630:Depsides; D062385:Hydroxybenzoates; D007783:Lactones; D019207:beta Carotene; C000875:depsidone; D002338:Carotenoids