title: Peroperative adenosine infusion reduces the requirements for isoflurane and postoperative analgesics.
abstract: The aims of this study were to investigate the influence of adenosine infusion, firstly, on postoperative analgesic requirements, and secondly, on peroperative isoflurane requirements. Seventy-five women, aged 18-70 yrs, ASA grades I and II, scheduled for breast surgery, were randomly assigned to peroperatively receive a double-blind intravenous infusion of either adenosine, 80 micrograms.kg-1.min-1, or placebo, during surgery under isoflurane/N2O/O2 anesthesia. The peroperative isoflurane requirements were significantly reduced at 30 and 90 min of surgery during adenosine treatment. The number of patients reporting pain when regaining consciousness after surgery was reduced by 57% in the adenosine group, 8/31 vs 19/32 (P < 0.02). Further, the postoperative 24-h opioid requirements were reduced by 27% in the adenosine group (P < 0.03). In conclusion, we found that a peroperative infusion of a small dose of adenosine during breast surgery, reduces the peroperative anesthetic requirements, and the demand for post-operative analgesics.
authors.affiliation: Department of Anesthesia and Intensive Care, Karolinska Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Segerdahl
authors.forename: A
authors.initials: A
authors.lastname: Ekblom
authors.forename: K
authors.initials: K
authors.lastname: Sandelin
authors.forename: M
authors.initials: M
authors.lastname: Wickman
authors.forename: A
authors.initials: A
authors.lastname: Sollevi
mesh_terms: D000241:Adenosine / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000758:Anesthesia; D016292:Procedural Sedation; D004311:Double-Blind Method; D005260:Female; D005425:Flicker Fusion; D006801:Humans; D007262:Infusions, Intravenous; D007432:Intraoperative Period; D007530:Isoflurane / Q000008:administration & dosage*; D016462:Mammaplasty; D008408:Mastectomy; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D000701:Analgesics, Opioid; D007530:Isoflurane; D000241:Adenosine