title: Baclofen therapy for chronic hiccup.
abstract: Chronic hiccup is a rare but potentially severe condition, that can be symptomatic of a variety of diseases, or idiopathic. Many therapeutic interventions have been reported, most often as case reports. Among other drugs, baclofen has been suggested as a therapy for chronic hiccup. In a large series of patients, we have evaluated its therapeutic position. In patients with chronic hiccup, defined as hiccup spell or recurring hiccup attacks lasting more than 7 days, investigation of the upper gastro-oesophageal tract (fibroscopy, manometry, and pH monitoring) was systematically performed. Most patients had tried numerous drugs in the past, without success. Baclofen was used as a first treatment in patients without evidence of any gastro-oesophageal disease (n = 17), and was undertaken only after full treatment of such disease (n = 55) had failed to solve the hiccup problem (n = 20). Baclofen has, therefore, been administered to 37 patients with chronic hiccup (average duration 4.6 yrs). Baclofen produced a long-term complete resolution (18 cases) or a considerable decrease (10 cases) of hiccups in 28 of the 37 patients. There was no significant difference between patients with or without gastro-oesophageal disease. We conclude that so-called idiopathic chronic hiccup often results from gastro-oesophageal abnormalities. Also, if controlled studies confirm our encouraging results, baclofen can be a major element in the treatment of chronic hiccup that is idiopathic, or that cannot be helped by treatment of gastro-oesophageal diseases.
authors.affiliation: Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Guelaud
authors.forename: T
authors.initials: T
authors.lastname: Similowski
authors.forename: J L
authors.initials: JL
authors.lastname: Bizec
authors.forename: J
authors.initials: J
authors.lastname: Cabane
authors.forename: W A
authors.initials: WA
authors.lastname: Whitelaw
authors.forename: J P
authors.initials: JP
authors.lastname: Derenne
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001418:Baclofen / Q000627:therapeutic use*; D002908:Chronic Disease; D020117:Cisapride; D004305:Dose-Response Relationship, Drug; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy; D006606:Hiccup / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D010880:Piperidines; D001418:Baclofen; D009853:Omeprazole; D020117:Cisapride