Modeling of cell culture processes.
Models of cell processes can be particularly useful in simulating, optimizing and controlling cell culture systems. Models reported in the literature are of various degrees of biological structure and mathematical complexity and describe cell growth, death, metabolism, and product formation, alone or in combination with each other. This paper reviews these modeling efforts, discusses their results, potential and limitations, and identifies areas where future modeling studies may be especially valuable.
Tziampazis
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E
School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332-0100.
Sambanis
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A
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured / Q000502:physiology*; D008954:Models, Biological