title: Segmental intestinal transplantation can be an adequate therapy for short bowel syndrome in growing dogs.
abstract: This study was undertaken to investigate whether two-stage segmental small bowel allotransplantation can maintain growth and development of young dogs (16 weeks, 5 to 6 kg) with surgically created short bowel syndrome (SBS). After near-total small bowel resection (group 1; n = 3), irreversible weight loss was noted. After a sham operation (group 2; n = 3), no growth disturbances were found. Major histocompatibility matched small bowel transplantation (SBT) with cyclosporine A as immunosuppressant, was performed in two stages (group 3; n = 7). During the first stage, one meter of jejunoileum from an adult donor was placed as a Roux loop. Four weeks later, the native small bowel was removed and replaced by the graft. Only one dog survived long-term; the dogs died from infectious complications. The addition of selective decontamination of the digestive tract and early gastrostomy feeding (group 4; n = 10) resulted in long-term survival in 60%. Follow-up at 4 months showed that their growth was about 20% compromised compared with that of the sham-operated animals. Functional analysis showed that electrolytes, urea, and D-xylose were normal, but there was an increase in the lactulose:mannitol ratio, fecal fat excretion, and postheparin diamine oxidase release. These results show that under the conditions described, segmental SBT functions sufficiently to treat SBS but does not maintain normal growth.
authors.affiliation: Department of Pediatric Surgery, Erasmus University Hospital, Rotterdam, The Netherlands.
authors.forename: M C
authors.initials: MC
authors.lastname: Wolvekamp
authors.forename: E
authors.initials: E
authors.lastname: Heineman
authors.forename: R L
authors.initials: RL
authors.lastname: Marquet
authors.forename: M A
authors.initials: MA
authors.lastname: Meijssen
authors.forename: R W
authors.initials: RW
authors.lastname: de Bruin
authors.forename: J C
authors.initials: JC
authors.lastname: Molenaar
mesh_terms: D000713:Anastomosis, Roux-en-Y; D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006650:Histocompatibility Testing; D007082:Ileum / Q000637:transplantation*; D007408:Intestinal Absorption / Q000502:physiology; D007583:Jejunum / Q000637:transplantation*; D008297:Male; D012778:Short Bowel Syndrome / Q000503:physiopathology / Q000601:surgery*; D014184:Transplantation, Homologous
chemical_list: D016572:Cyclosporine