Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta.
Diffractaic acid and usnic acid were identified as the analgesic and antipyretic components of a lichen, Usnea diffracta. Both compounds showed an analgesic effect by the acetic acid-induced writhing and tail-pressure methods in mice. Regarding the effect on normal body temperature and LPS-induced hyperthermia in mice, diffractaic acid showed a significant effect only on the former and usnic acid only on the latter.
Okuyama
E
E
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Umeyama
K
K
Yamazaki
M
M
Kinoshita
Y
Y
Yamamoto
Y
Y
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000494:pharmacology*; D000840:Anisoles / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D062385:Hydroxybenzoates / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000840:Anisoles; D001572:Benzofurans; D062385:Hydroxybenzoates; C073339:usnic acid; C093528:diffractaic acid