[The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress].
The course of administration of Rhodiola rosea extract was studied for effects on the pattern of stress-induced cardiac damage which was assessed by 99mTc-pyrophosphate accumulation in the heart. Rhodiola rosea was found to prevent stress-induced cardiac damage. Simultaneously, myocardial catecholamines and cAMP levels were measured. Rhodiola rosea was ascertained to prevent both stress-induced catecholamine release and higher cAMP levels in the myocardium. Moreover, the adaptogen prevented lower adrenal catecholamines during stress. The findings suggest that the antistressor and cardioprotective effects of Rhodiola rosea are associated with limited adrenergic effect on the heart.
Maslova
L V
LV
Kondrat'ev
B Iu
BIu
Maslov
L N
LN
Lishmanov
Iu B
IuB
D018674:Adrenergic Antagonists / Q000627:therapeutic use*; D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003080:Cold Temperature / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000000981:diagnostic imaging; D009206:Myocardium / Q000378:metabolism; D010936:Plant Extracts / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D016698:Technetium Tc 99m Pyrophosphate
D018674:Adrenergic Antagonists; D002317:Cardiovascular Agents; D010936:Plant Extracts; D016698:Technetium Tc 99m Pyrophosphate
O kardioprotektornoĭ i antiadrenergicheskoĭ aktivnosti ékstrakta rodioly rozovoĭ pri stresse.