Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines.
Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of C-C chemokines, monocyte chemotactic protein-1 (MCP-1), MCP-2, and MCP-3, in particular, encompasses, in addition to monocytes, other leukocyte populations. Evidence is presented that MCP-1, MCP-2, and MCP-3 are active on natural killer cells. Available information on receptor usage by MCP-1 and related chemokines and signal transduction pathways is reviewed. A better understanding of signaling mechanisms will provide a new basis for therapeutic strategies.
Sozzani
S
S
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Locati
M
M
Zhou
D
D
Rieppi
M
M
Luini
W
W
Lamorte
G
G
Bianchi
G
G
Polentarutti
N
N
Allavena
P
P
Mantovani
A
A
D002118:Calcium / Q000502:physiology; D018932:Chemokine CCL2; D002630:Chemotactic Factors / Q000502:physiology*; D002633:Chemotaxis; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D009000:Monocytes / Q000502:physiology; D018121:Receptors, Cytokine / Q000502:physiology*; D011994:Recombinant Proteins; D015398:Signal Transduction
D018932:Chemokine CCL2; D002630:Chemotactic Factors; D016207:Cytokines; D018121:Receptors, Cytokine; D011994:Recombinant Proteins; D002118:Calcium