[Aseptic adenitis in pyoderma gangrenosum].
BACKGROUND
Extra-cutaneous manifestations of neutrophilic dermatosis are rare. Symptomatic cases are usually multiform and confusing. We report a case with an aseptic lymph node abscess associated with pyoderma gangrenosum.


METHODS
A 28-year-old woman with past history of pyoderma gangrenosum was seen for abdominal symptoms and fever related to an epigastric mass. Due to signs indicating abscess formation, surgery was performed and led to total regression of the symptomatology. Recurrence was evidenced 3 months later with skin lesions which were negative on bacteriological examinations. The diagnosis of lymph node manifestations of pyoderma gangrenosum was retained. General corticotherapy was very effective. Relapse occurred again 6 years later and was treated with thalidomide.


CONCLUSIONS
Lymph node involvement has been described in Sneddon-Wilkinson's disease associated with pyoderma gangrenosum. In neutrophilic dermatosis, pulmonary manifestations appear to be the least exceptional of the extra-cutaneous lesions. The pathophysiology has not been elucidated although recent hypotheses suggest that G-CSF could be involved. Corticotherapy is remarkably effective in most cases but thalidomide could be an interesting alternative treatment.
Costa
I
I
Service de Dermatologie, Hôpital Pasteur, Nice.
Castanet
J
J
Taillan
B
B
Lacour
J P
JP
Perrin
C
C
Chazal
M
M
Mondain
V
V
Ortonne
J P
JP
D015746:Abdominal Pain / Q000209:etiology; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001207:Asepsis; D005260:Female; D006801:Humans; D008199:Lymphadenitis / Q000209:etiology*; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000188:drug therapy; D011860:Radiography, Abdominal; D013792:Thalidomide / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000305:Adrenal Cortex Hormones; D013792:Thalidomide
Adénites aseptiques au cours d'un pyoderma gangrenosum.