title: [Right ventricular thrombi in primary antiphospholipid syndrome].
abstract: Over a period of several months a 33-year-old man had recurrent pulmonary emboli. No thromboses could be demonstrated in the peripheral venous system. Transoesophageal echocardiography showed two spherical space-occupying structures in the right ventricle which were removed operatively under the suspected diagnosis of multilobular myxomas. However, their histological examination revealed pure thrombi that had grown by apposition. This unusual findings of right-ventricular thrombi could not be explained pre- and intraoperatively by any local thrombi-favouring changes in the right heart. Tests of clotting mechanisms demonstrated lupus anticoagulant (kaolin-clotting-time mixture test: LA index 21.7 [normal: < 15]), as well as an increased IgG cardiolipin antibody concentration of 19.3 U/l). As no underlying disease was discovered, the diagnosis was by definition primary antiphospholipid syndrome. No further thrombo-embolism has occurred during continuing oral anticoagulation with phenprocoumon.
authors.affiliation: Fachbereich Kardiologie, Deutsche Klinik für Diagnostik, Wiesbaden.
authors.forename: S
authors.initials: S
authors.lastname: Bräuninger
authors.forename: G
authors.initials: G
authors.lastname: Winckelmann
authors.forename: R M
authors.initials: RM
authors.lastname: Bohle
authors.forename: E
authors.initials: E
authors.lastname: Bauer
authors.forename: M
authors.initials: M
authors.lastname: Stellwaag
authors.forename: H
authors.initials: H
authors.lastname: Lambertz
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D006331:Heart Diseases / Q000150:complications / Q000175:diagnosis* / Q000517:prevention & control; D006338:Heart Neoplasms / Q000175:diagnosis; D006352:Heart Ventricles; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D009232:Myxoma / Q000175:diagnosis; D010644:Phenprocoumon / Q000627:therapeutic use; D011655:Pulmonary Embolism / Q000209:etiology; D012008:Recurrence; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis* / Q000517:prevention & control
chemical_list: D016682:Lupus Coagulation Inhibitor; D010644:Phenprocoumon
vernacular_title: Rechtsventrikuläre Thromben bei primärem Antiphospholipid-Syndrom.