title: Hypopigmented variant of mycosis fungoides: demography, histopathology, and treatment of seven cases.
abstract: BACKGROUND
  Hypopigmented macules have been described infrequently as a presenting form of mycosis fungoides (MF).
  
  
  OBJECTIVE
  This study was designed to clarify general characteristics of a hypopigmented MF variant.
  
  
  METHODS
  Seven new cases were investigated with the use of descriptive epidemiology techniques. Demographic parameters, histopathology, and treatment outcomes were analyzed. These data were combined with those from prior reports to develop a broad composite view of this disease process.
  
  
  RESULTS
  The median ages in our series were 36 years for disease onset and 39 years at biopsy diagnosis. All patients had brown or black skin. Histologic findings consistently showed a lack of epidermal atrophy and moderate to profound exocytosis. Treatment with PUVA induced rapid and complete repigmentation in six of seven patients.
  
  
  CONCLUSIONS
  On the basis of our experience and a literature review, the hypopigmented variant of MF occurs in a younger population than typical forms of the disease and affects persons with dark skin almost exclusively. Microscopic features include lack of epidermal atrophy and moderate to extreme epidermotropism of infiltrating mononuclear cells. The treatment of choice appears to be PUVA.
authors.affiliation: Department of Dermatology, Beth Israel Medical Center, New York, NY 10003, USA.
authors.forename: E
authors.initials: E
authors.lastname: Lambroza
authors.forename: S R
authors.initials: SR
authors.lastname: Cohen
authors.forename: R
authors.initials: R
authors.lastname: Phelps
authors.forename: M
authors.initials: M
authors.lastname: Lebwohl
authors.forename: I M
authors.initials: IM
authors.lastname: Braverman
authors.forename: D
authors.initials: D
authors.lastname: DiCostanzo
mesh_terms: D000328:Adult; D044383:Black People; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications* / Q000473:pathology / Q000628:therapy; D011701:PUVA Therapy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy