title: Nephrotoxicity in lambs apparently caused by experimental feeding with Narthecium ossifragum.
abstract: Seven lambs were fed a mixture of bog plants containing 15 g (wet matter) Narthecium ossifragum per kg live weight for 10 consecutive days. Their serum creatinine concentration increased from day 1 to 4 but then fell to normal by day 6 after feeding started. In the same animals, the serum magnesium concentration was increased on days 3, 4 and 5. Histopathological examination of the kidneys of 2 lambs killed after being fed 25 g N. ossifragum per kg live weight for one day revealed tubular epithelial cell degeneration and necrosis. There were no signs of disease or distress in the experimental animals and their appetite remained normal throughout the experimental period. It was concluded that N. ossifragum is probably nephrotoxic to lambs.
authors.affiliation: Department of Reproduction and Forensic Medicine, Norwegian College of Veterinary Medicine, Oslo.
authors.forename: A
authors.initials: A
authors.lastname: Flåøyen
authors.forename: B
authors.initials: B
authors.lastname: Bratberg
authors.forename: H
authors.initials: H
authors.lastname: Grønstøl
mesh_terms: D000821:Animal Feed / Q000009:adverse effects*; D000818:Animals; D003404:Creatinine / Q000097:blood; D004848:Epithelium / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D009336:Necrosis; D010947:Plants, Toxic; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology* / Q000473:pathology
chemical_list: D003404:Creatinine