Inhibition of glycolysis in boar spermatozoa by 1,6-dichloro-1,6-dideoxy-D-fructose.
The dichloro-analogue of D-fructose 1,6-bisphosphate, 1,6-dichloro-1,6-dideoxy-D-fructose, is a weak substrate for boar sperm aldolase which converts it to (S)-3-chlorolactaldehyde and 3-chloro-1-hydroxypropanone in vitro. Production of these chloro-trioses leads to the strong inhibition of glyceraldehyde-3-phosphate dehydrogenase, the weak inhibition of triosephosphate isomerase and the transient inhibition of aldolase.
Jones
A R
AR
Department of Biochemistry, University of Sydney, NSW, Australia.
Morin
C
C
D000818:Animals; D003837:Deoxy Sugars / Q000494:pharmacology*; D005298:Fertility / Q000187:drug effects; D005632:Fructose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D008297:Male; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism; D013552:Swine; D014305:Triose-Phosphate Isomerase / Q000378:metabolism
D003837:Deoxy Sugars; D007773:Lactates; D005632:Fructose; C059610:1,6-dichloro-1,6-dideoxyfructose; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D005634:Fructose-Bisphosphate Aldolase; D014305:Triose-Phosphate Isomerase; D005947:Glucose; D005990:Glycerol