Effect of neurotropin on cerebral edema, calcium and other elements in mice subarachnoidally injected with carrageenan.
Neurotropin, an inhibitor of the kallikrein-kinin system, was therapeutically i.p. administered to mice with brain inflammation induced by subarachnoidal injection of carrageenan. Brain water content was determined by the wet/dry weight ratio. The concentrations of cerebral Ca, K, Mn, Fe, Cu, Zn, Se, Rb, and Sr were measured by particle-induced X-ray emission. It was found that neurotropin dose dependently reduced brain water content. The mean concentration of cerebral calcium was significantly lower in the neurotropin-treated group than that in the non-treated group, suggesting less cell damage. Since it has been reported that dexamethasone and some prostaglandin inhibitors have no effect on brain swelling in this model and that, in contrast to these drugs, neurotropin has only a weak inhibiting activity on carrageenan-induced paw swelling, it is hypothesized that the kallikrein-kinin system is differently implicated in cerebral and peripheral inflammation.
Sprumont
P
P
Institute of Anatomy and Special Embryology, University of Fribourg, Switzerland.
Kaelin-Lang
A
A
Van Lierde
S
S
Maenhaut
W
W
De Reuck
J
J
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001099:Arachnoid / Q000187:drug effects / Q000378:metabolism; D001929:Brain Edema / Q000139:chemically induced / Q000188:drug therapy*; D002118:Calcium / Q000378:metabolism*; D002351:Carrageenan / Q000008:administration & dosage / Q000633:toxicity; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007501:Iron / Q000378:metabolism; D016234:Kallikrein-Kinin System / Q000187:drug effects; D016014:Linear Models; D008297:Male; D008345:Manganese / Q000378:metabolism; D051379:Mice; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011188:Potassium / Q000378:metabolism; D012413:Rubidium / Q000378:metabolism; D012643:Selenium / Q000378:metabolism; D013052:Spectrometry, X-Ray Emission; D014867:Water / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D000700:Analgesics; D011134:Polysaccharides; D014867:Water; D008345:Manganese; C010491:neurotropin; D003300:Copper; D002351:Carrageenan; D007501:Iron; D012643:Selenium; D015032:Zinc; D012413:Rubidium; D011188:Potassium; D002118:Calcium