Conformational analysis and biological activity of leptocarpin and leptocarpin acetate.
This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition of [35S]-methionine uptake without affecting the (methyl-3H)thymidine and (5,6-3H)uridine incorporation, when assayed in HeLa cells.
Martínez
R
R
Kesternich
V
V
Gutierrez
E
E
Dölz
H
H
Mansilla
H
H
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D002236:Carbohydrate Conformation; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology
D012717:Sesquiterpenes; C093535:leptocarpin acetate; C093534:leptocarpin; D015107:4-Butyrolactone