title: Hydroxylation of progesterone by Cephalosporium aphidicola.
abstract: The fungus, Cephalosporium aphidicola, has been shown to hydroxylate progesterone predominantly at the 6 beta- and 11 alpha-positions. Minor metabolites include testosterone acetate, the 20(R)-alcohol and 12 beta, 17 alpha-dihydroxy-progesterone. The sequence involves hydroxylation at 11 alpha and then 6 beta. The hydroxylations of 11 alpha- and 17 alpha-hydroxyprogesterone and of 9 beta, 10 alpha-retroprogesterone have also been examined in the light of these results.
authors.affiliation: School of Molecular Sciences, University of Sussex, Brighton, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Farooq
authors.forename: J R
authors.initials: JR
authors.lastname: Hanson
authors.forename: Z
authors.initials: Z
authors.lastname: Iqbal
mesh_terms: D000164:Acremonium / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D011374:Progesterone / Q000378:metabolism*; D013055:Spectrophotometry, Infrared
chemical_list: D011374:Progesterone