title: The incidence of cutting fluid dermatitis among metalworkers in a metal fabrication factory: a prospective study.
abstract: We compared the incidence of occupational dermatitis and transepidermal water vapour loss (TEWL) changes from cutting fluids (neat mineral oils) in 24 new machinists with 27 armed forces paramedics (controls) over a 6-month period. The cumulative incidence of occupational dermatitis in positive controls increased from 38% at week 3 to 77% at week 6. It then decreased to 50% at week 9 and thereafter remained constant at about 50% throughout the remaining study period. 2 workers sought medical treatment for their dermatitis. Only 1 worker had a job transfer because of his dermatitis. None of the paramedics developed dermatitis during the study period. The mean basal TEWL values on the hands of machinists and controls were 17.6 and 14.5 g/m2/h (n.s.) respectively. The mean TEWL values of machinists increased to 22 g/m2/h by week 3 and then remained fairly constant throughout the remaining study period. The mean TEWL of negative controls remained fairly constant (at about 14 g/m2/h) from the beginning to the end of the study period. The mean TEWL value of machinists was significantly higher than that of negative controls throughout the study period. There was no significant difference in the prevalence of cutting fluid dermatitis between machinists with high basal TEWL values (> or = 17 g/m2/h) and those with low basal TEWL values (< 17 g/m2/h).
authors.affiliation: National Skin Centre, Singapore.
authors.forename: C L
authors.initials: CL
authors.lastname: Goh
authors.forename: S L
authors.initials: SL
authors.lastname: Gan
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D017453:Dermatitis, Irritant / Q000209:etiology* / Q000503:physiopathology; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D008297:Male; D008669:Metallurgy; D008899:Mineral Oil / Q000009:adverse effects*; D015995:Prevalence; D011446:Prospective Studies; D014870:Water Loss, Insensible
chemical_list: D008899:Mineral Oil