Multifocal osteomyelitis caused by Paecilomyces varioti in a patient with chronic granulomatous disease.
This report describes an 18-year-old male patient with chronic granulomatous disease who developed cutaneous nodules and multifocal osteomyelitis with the saprophytic fungus Paecilomyces varioti. After several biopsies the organism was identified. Anti-fungal susceptibility testing was performed. Combination therapy with amphotericin B and gamma-interferon followed by long-term therapy with itraconazole and gamma-interferon resulted in a clinical response.
Cohen-Abbo
A
A
Dept. of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2581, USA.
Edwards
K M
KM
D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage; D017964:Itraconazole / Q000008:administration & dosage; D008297:Male; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology*; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology*; D010143:Paecilomyces / Q000302:isolation & purification*
D017964:Itraconazole; D000666:Amphotericin B; D007371:Interferon-gamma