Structure of malformin B, a phytotoxic metabolite produced by Aspergillus niger.
Malformin B, produced by Aspergillus niger, was separated into six compounds by HPLC. Their structures were determined by amino acid analyses, and by mass spectral and two-dimensional NMR experiments to be cyclic pentapeptides structurally related to malformin A1. Both the NMR and MS/MS experiments suggest cyclo-D-cysteinyl-D-cysteinyl-L-amino acid-D-amino acid-L-amino acid as the essential structure of malformins.
Kim
K W
KW
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Sugawara
F
F
Yoshida
S
S
Murofushi
N
N
Takahashi
N
N
Curtis
R W
RW
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001234:Aspergillus niger / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification
D000596:Amino Acids; D010456:Peptides, Cyclic; C001675:malformins