title: [Reduction of thyroid volume following radioiodine therapy for functional autonomy].
abstract: In a retrospective study we evaluated the data of 112 patients who underwent radioiodine treatment for functional autonomy of the thyroid at Essen University Hospital from 1988 to 1993. Therapeutic activities of radioiodine were administered after individual determination of activity for intended radiation doses (150-300 Gy) taking into consideration autonomously functioning volume, maximum uptake, and effective half-life. The achieved dose was calculated by means of measurement of the radioiodine kinetics during therapy. Depending on the type of autonomous function of the thyroid (solitary autonomously functioning nodule, multiple autonomously functioning nodules, autonomously functioning thyroid tissue) volume reductions between 39 and 46% were found approximately 6 months after treatment.
authors.affiliation: Klinik und Poliklinik für Nuklearmedizin der Universität-GHS-Essen, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Luster
authors.forename: M
authors.initials: M
authors.lastname: Jacob
authors.forename: M H
authors.initials: MH
authors.lastname: Thelen
authors.forename: U
authors.initials: U
authors.lastname: Michalowski
authors.forename: U
authors.initials: U
authors.lastname: Deutsch
authors.forename: C
authors.initials: C
authors.lastname: Reiners
mesh_terms: D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D008297:Male; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000378:metabolism / Q000503:physiopathology* / Q000532:radiotherapy*; D013961:Thyroid Gland / Q000378:metabolism / Q000503:physiopathology / Q000528:radiation effects
chemical_list: D007457:Iodine Radioisotopes
vernacular_title: Reduktion des Schilddrüsen-volumens nach Radiojodtherapie wegen funktioneller Autonomie.