Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease.
OBJECTIVE
To determine the changes in basal ganglia iron content associated with various stages of idiopathic Parkinson's disease.


METHODS
Prospective magnetic resonance imaging study using a 2-T magnet.


METHODS
Ambulatory care referral center.


METHODS
Forty-five patients suffering from levodopa-responsive Parkinson's disease and 45 age-matched controls.


METHODS
The T2 relaxation time calculated in various regions of the basal ganglia, the duration of Parkinson's disease, and the age of subjects.


RESULTS
Patients with Parkinson's disease exhibited significantly decreased T2 relaxation time in the pars compacta of the substantia nigra compared with controls (P < .01), regardless of disease duration. Patients with a duration of illness above 10 years (n = 12) exhibited significantly increased T2 relaxation time in the anterior and posterior putamen (P < .005 and P < .01, respectively) and in the pallidum (P < .05) compared with age-matched controls. Putamental T2 relaxation time positively correlated with disease duration (P < .05).


CONCLUSIONS
These results suggest that more complex brain iron changes than those previously reported are associated with idiopathic Parkinson's disease, including increased nigral iron content and decreased putamenal and pallidal iron concentration in patients with a duration of illness above 10 years.
Ryvlin
P
P
Department of Neurology, Hôpital Neurologique, Lyon, France.
Broussolle
E
E
Piollet
H
H
Viallet
F
F
Khalfallah
Y
Y
Chazot
G
G
D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000378:metabolism*; D011446:Prospective Studies; D011699:Putamen / Q000378:metabolism* / Q000473:pathology
D007501:Iron