title: Spatial localization of pre-mRNA transcription and processing within the nucleus.
abstract: The organization of transcription, processing, and transport of pre-mRNA within the nucleus is a major unsolved problem in cell biology. Several recent studies have helped to define the localization of specific DNAs, RNAs, and proteins within the nucleus and have led to various models for higher level organization of pre-mRNA metabolism.
authors.affiliation: Human Genome Sciences Inc, Rockville.
authors.forename: K C
authors.initials: KC
authors.lastname: Carter
mesh_terms: D000818:Animals; D001692:Biological Transport; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D011506:Proteins / Q000235:genetics; D012319:RNA Polymerase II / Q000235:genetics; D012322:RNA Precursors / Q000235:genetics* / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D011506:Proteins; D012322:RNA Precursors; D012333:RNA, Messenger; D012319:RNA Polymerase II