title: An automated [15Q]H2O production and injection system for PET imaging.
abstract: A computer controlled [15O]H2O injection system has been designed for multiple bolus injections during PET cerebral blood flow studies. The system is housed in a lead safe, and radiation exposure to nearby personnel is low; we have measured rates of approx. 100 microSv/h (10 mR/h) during 2 min of [15O]H2O production and < 50 microSv/h (< 5 mR/h) after 3.7 GBq (100 mCi) has been produced. Reproducibility studies show that the injected activity varies with a coefficient of variation of 2-3%.
authors.affiliation: PET Imaging Service, VA Medical Center, Minneapolis, MN 55417, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Palmer
authors.forename: M
authors.initials: M
authors.lastname: Sajjad
authors.forename: D A
authors.initials: DA
authors.lastname: Rottenberg
mesh_terms: D001331:Automation / Q000295:instrumentation / Q000379:methods; D002560:Cerebrovascular Circulation; D017357:Cyclotrons; D006801:Humans; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods; D008838:Microcomputers; D010104:Oxygen Radioisotopes; D012984:Software; D013997:Time Factors; D014055:Tomography, Emission-Computed; D014867:Water
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water