The influence of ketanserin or urapidil on haemodynamics, stress response and kidney function during operations for myocardial revascularisation.
The study was performed to investigate the different effects of ketanserin and urapidil on haemodynamics, kidney function and plasma catecholamine and aldosterone levels. Forty male patients scheduled for myocardial revascularisation were assigned at random to two groups: group K received ketanserin, group U received urapidil. Anaesthesia consisted of fentanyl, flunitrazepam and pancuronium. Haemodynamic variables were evaluated at eight predefined time points of the operation. Creatinine and free-water clearance as well as plasma levels of adrenaline, noradrenaline and aldosterone were measured in three different periods of the operation. While the groups showed no clinically relevant differences in the haemodynamic variables and the hormone plasma concentrations, the creatinine clearance in group K was slightly increased in the period after cardiopulmonary bypass. Both ketanserin and urapidil prevented hypertension even in the presence of elevated catecholamine plasma levels during and after cardiopulmonary bypass.
Petry
A
A
Clinic for Anaesthesiology and Intensive Care Medicine, University of Kiel, Germany.
Wulf
H
H
Baumgärtel
M
M
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004311:Double-Blind Method; D004837:Epinephrine / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D007650:Ketanserin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D009638:Norepinephrine / Q000097:blood; D010879:Piperazines / Q000494:pharmacology*; D011446:Prospective Studies
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D010879:Piperazines; D007650:Ketanserin; C015568:urapidil; D009638:Norepinephrine; D004837:Epinephrine