[The effect of isradipine on the morphine-activated self-stimulation reaction in rats].
Lateral hypothalamic self-stimulation in rats was studied using two schedules of reinforcement: continuous reinforcement and fixed-ratio schedule. Isradipine, the blocker of calcium channels (1, 2, 4 mg/kg, subcutaneously) dose-dependently decreased self-stimulation rate and increased the threshold intensity in continuous reinforcement schedule, as well as suppressed self-stimulation under fixed-ratio schedule. The data obtained count in favour of common dihydropyridine-sensitive mechanism of the reinforcing effect of both electrical and pharmacological activation of the brain reward system.
Bespalov
A Iu
AIu
Zvartau
E E
EE
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D017275:Isradipine / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012044:Regression Analysis; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology
D009020:Morphine; D017275:Isradipine
Vliianie izradipina na aktivirovannuiu morfinom reaktsiiu samostimuliatsii u krys.