Dismantling the immune system.
During the past year, we have witnessed a veritable explosion in the number of mutant mouse strains produced by gene targeting in embryonic stem cells. Many of the informative targeted mutants have relevance to the field of immunology. At least one mutant mouse strain now exists for most of the important genes in immunology, and this collection of mutant mice has greatly expanded the experimental repertoire of immunologists. New targeting techniques have been developed that have often found their first application in immunology.
Mombaerts
P
P
Massachusetts Institute of Technology, Cambridge.
D000818:Animals; D007107:Immune System; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology*; D016296:Mutagenesis; D009154:Mutation; D012045:Regulatory Sequences, Nucleic Acid