title: Ring 22 chromosomes in dermatofibrosarcoma protuberans are low-level amplifiers of chromosome 17 and 22 sequences.
abstract: Ring chromosomes have been found with some regularity as solid tumors have come increasingly under cytogenetic study. The full genetic content and significance of these rings remain unclear. Dermatofibrosarcoma protuberans, a tumor of the deep dermis, consistently has supernumerary ring chromosomes, sometimes as the sole detectable cytogenetic change. Using a modified method for comparative genomic hybridization and fluorescent in situ hybridization with a panel of various probes, we found that these ring chromosomes consistently contain the chromosome 22 centromere along with interstitial sequences from chromosomes 17 and 22, specifically from regions 17q23-24 and 22q11-12. The ring chromosomes in dermatofibrosarcoma protuberans are vehicles for a particular pattern of relatively low-level genomic amplification of selected sequences.
authors.affiliation: Laboratoire de Génetique Moléculaire des Cancers Humains, Centre National de la Recherche Scientifique URA 1462, Faculté de Médecine, Nice, France.
authors.forename: F
authors.initials: F
authors.lastname: Pedeutour
authors.forename: M P
authors.initials: MP
authors.lastname: Simon
authors.forename: F
authors.initials: F
authors.lastname: Minoletti
authors.forename: G
authors.initials: G
authors.lastname: Sozzi
authors.forename: M A
authors.initials: MA
authors.lastname: Pierotti
authors.forename: F
authors.initials: F
authors.lastname: Hecht
authors.forename: C
authors.initials: C
authors.lastname: Turc-Carel
mesh_terms: D000328:Adult; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D018223:Dermatofibrosarcoma / Q000235:genetics*; D005784:Gene Amplification; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009693:Nucleic Acid Hybridization; D012303:Ring Chromosomes; D012878:Skin Neoplasms / Q000235:genetics*