[The distribution and pharmacokinetics in lung of bovine serum albumin microspheres for pulmonary targeting in mice].
125I-labeled bovine serum albumin microspheres loaded cisplatinum (CDDP-125I-BSA-MS) with the size range of 7-25 microns were prepared and injected into the tail vein of mice. The results showed that the microspheres were accumulated almost entirely in the lung after i.v. injection (about 97.52% injected dose at the highest concentration). While in blood and other organs almost no accumulation was found. Photomicrographs showed that microspheres reached the lung and lodged in precapillary arteriols and capillaries of lung. The microspheres in lung were eliminated gradually. The pharmacokinetics of microspheres in lung of mice was also studied with "practical pharmacokinetic program-version 87", and was fitted by two-compartment model with i.v. injection or one-compartment model with 1st order absorption, but the meaning of some parameters changed. Based on the analysis of the models and parameters, it was concluded that the pharmacokinetics of microspheres in lungs can be described by the model of "one-compartment of first-order intake and first-order elimination".
Zhang
M
M
Hou
S
S
Gong
T
T
Cheng
Y
Y
Liao
G
G
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D008168:Lung / Q000378:metabolism*; D051379:Mice; D008863:Microspheres; D012710:Serum Albumin, Bovine
D004337:Drug Carriers; D012710:Serum Albumin, Bovine; D002945:Cisplatin