title: Bifidobacteria and probiotic effects: action of Bifidobacterium species on conjugated bile salts.
abstract: The effect of six different conjugated bile salts (two trihydroxyconjugated bile salts: tauro and glycocholic acids; and four dihydroxyconjugated bile salts: tauro- and glycochenodeoxycholic, tauro- and glycodeoxycholic acids) on eight bifidobacteria strains were studied. A strong growth-inhibitory effect was observed (80% at 0.95 mM) for each bile salt and strain. This phenomenon was explained by the production of deconjugated bile salt during bifidobacteria growth. The deconjugation phenomenon was concurrent with biomass production, and deconjugated bile salts were the sole compound produced during bifidobacteria biotransformation. In resting cell experiments, differences appeared between the strains and the kind of bile salts, particularly concerning taurocholic acid. The Bifidobacterium longum strains were the most efficient among the bacteria tested.
authors.affiliation: Université de Nancy I, Institut Henry Tissier, Laboratoire de Chimie Biologique I, Vandoeuvre lès Nancy, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Grill
authors.forename: C
authors.initials: C
authors.lastname: Manginot-Dürr
authors.forename: F
authors.initials: F
authors.lastname: Schneider
authors.forename: J
authors.initials: J
authors.lastname: Ballongue
mesh_terms: D001644:Bifidobacterium / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D001647:Bile Acids and Salts / Q000493:pharmacokinetics / Q000494:pharmacology*; D001711:Biotransformation; D013045:Species Specificity
chemical_list: D001647:Bile Acids and Salts