title: [A comparative study of the effect of hepatoprotectors and inducers on cardiogreen pharmacokinetics in acute toxic hepatitis in the prepuberty period].
abstract: CCl4 given to Chinchilla rabbits aged 1 month caused impaired pharmacokinetics of cardiogrin, indicating suppression of absorptive and excretory functions of the liver in prepuberty. Silibor was found to produce no substantial restorative effects on hepatic absorptive and excretory functions in acute toxic hepatitis in the growing body. Phytin was shown to be not inferior to zyxorin and benzonal was superior to all the agents under study in activity.
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Khakimov
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Rakhmanov
mesh_terms: D000208:Acute Disease; D000818:Animals; D001463:Barbiturates / Q000627:therapeutic use; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004790:Enzyme Induction / Q000187:drug effects; D005419:Flavonoids / Q000627:therapeutic use; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D010833:Phytic Acid / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use; D011817:Rabbits
chemical_list: D001463:Barbiturates; D001559:Benzhydryl Compounds; D005419:Flavonoids; D010936:Plant Extracts; C061938:silibor; D010833:Phytic Acid; D007208:Indocyanine Green; C016914:flumecinol; C002915:benzobarbital
vernacular_title: Sravnitel'noe izuchenie vliianiia gepatoprotektorov i induktorov na farmakokinetiku kardiogrina pri ostrom toksicheskom gepatitie v predpubertatnom periode.