The turkey prolactin-encoding gene and its regulatory region.
Overlapping prolactin (Prl) lambda clones were isolated from a turkey genomic library. The 6.7-kb turkey Prl gene consists of five exons. Major transcription start points were located by primer extension 51-53 nucleotides upstream from the Met start codon. No estrogen response element (ERE) was found, but two regions similar to mammalian Pit-1/GHF-1-binding sites were identified by computer analysis. This suggests that transcription of the turkey Prl gene may be regulated by Pit-1/GHF-1, and not by the estrogen receptor.
Kurima
K
K
Virginia Polytechnic Institute and State University, Blacksburg 24061-0306, USA.
Proudman
J A
JA
El Halawani
M E
ME
Wong
E A
EA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004967:Estrogens / Q000494:pharmacology; D015698:Genomic Library; D008969:Molecular Sequence Data; D011388:Prolactin / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D014158:Transcription, Genetic; D014422:Turkeys
D004967:Estrogens; D011388:Prolactin