title: Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice.
abstract: The concept of tumour surveillance implies that specific and non-specific components of the immune system eliminate tumours in the early phase of malignancy. The immunological mechanisms that control growth of preneoplastic cells are, however, not known. T cells expressing gamma delta T-cell receptors (TCR) were first described as lymphocytes with reactivity against various tumour cells, which suggests that gamma delta T cells could mediate tumour surveillance. Here we show that TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice are spontaneously resistant to acute T-cell leukaemias but cannot reject non-haematopoietic tumours. TCRV gamma 1.1J gamma 4C gamma 4+ hybridomas isolated from these mice react in vitro against almost all haematopoietic tumour cell lines tested. Recognition of tumour cells depends on the gamma delta TCR but is independent of major histocompatibility complex (MHC) class I, MHC class II, or TAP-2 peptide transporter expression. Ligand recognition is influenced by the murine Nromp gene, which confers resistance or susceptibility to tuberculosis, lepra and leishmaniasis. These data indicate that TCRV gamma 1.1+ T cells confer spontaneous immunity against haematopoietic tumours in vivo and link innate resistance to bacterial infections with tissue-specific tumour surveillance by gamma delta+ T cells.
authors.affiliation: Amgen Institute, Ontario Cancer Institute, Toronto, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Penninger
authors.forename: T
authors.initials: T
authors.lastname: Wen
authors.forename: E
authors.initials: E
authors.lastname: Timms
authors.forename: J
authors.initials: J
authors.lastname: Potter
authors.forename: V A
authors.initials: VA
authors.lastname: Wallace
authors.forename: T
authors.initials: T
authors.lastname: Matsuyama
authors.forename: D
authors.initials: D
authors.lastname: Ferrick
authors.forename: B
authors.initials: B
authors.lastname: Sydora
authors.forename: M
authors.initials: M
authors.lastname: Kronenberg
authors.forename: T W
authors.initials: TW
authors.lastname: Mak
mesh_terms: D016475:3T3 Cells; D000818:Animals; D006825:Hybridomas / Q000276:immunology; D007113:Immunity, Innate; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009163:Mycobacterium bovis / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta