[Acute pancreatitis due to antimonials in patients with visceral leishmaniasis and HIV infection].
Acute pancreatitis is an adverse effect of the treatment with antimonial drugs which is infrequently described in patients with HIV infection and visceral leishmaniasis (VL). Twenty-two percent of the patients having this treatment had acute pancreatitis (7 cases) in the authors' center. In all the cases, severe immunosuppression was present with pancreatitis appearing following the administration of 3,400 to 15,300 mg of stibogluconate. The pancreatitis was slight in the 7 cases with no complications of note and with no symptoms observed in three cases. The maximum values of amylasemia ranged from 976 to 2,568 U/l, from 1,055 to 5,860 U/l for lipasemia, and from 1,970 to 25,520 U/l for trypsinemia. These values returned to normal from 15 days to 2 months after suppression of the drug. Stibogluconate was readministered in three patients due to VL recurrence with a further acute pancreatitis being observed. The authors conclude that acute pancreatitis is a relatively infrequent complication of antimonial treatment for VL in patients with HIV infection and believe that a maximum dose of 850 mg/day should not be surpassed.
Cortés
E
E
Servicio de Medicina Interna, Hospital General Universitario Vall d'Hebron, Universidad Autónoma, Barcelona.
Ribera
E
E
Cucurull
E
E
de Otero
J
J
Ocaña
I
I
Pahissa
A
A
D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000188:drug therapy; D000208:Acute Disease; D000328:Adult; D000967:Antimony Sodium Gluconate / Q000008:administration & dosage / Q000009:adverse effects*; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004796:Clinical Enzyme Tests; D005260:Female; D015497:HIV-1; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000009:adverse effects*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis; D012008:Recurrence
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000967:Antimony Sodium Gluconate
Pancreatitis aguda por antimoniales en pacientes con leishmaniasis visceral e infección por VIH.