title: Debrisoquine hydroxylation in a Polish population.
abstract: The genetic polymorphism of drug oxidation mediated by cytochrome P450IID6 (CYP2D6) was determined in 154 Polish volunteers using debrisoquine as the test substance. The results showed a bimodal distribution of the debrisoquine metabolic ratio (MR). Nine persons (5.8%) with MR > 12.6 were classified as poor metabolisers (gene frequency 0.242), which is in substantial agreement with the data reported for other Caucasian populations.
authors.affiliation: Department of Clinical Biochemistry, National Institute of Cardiology, Warszawa, Poland.
authors.forename: P K
authors.initials: PK
authors.lastname: Kunicki
authors.forename: D
authors.initials: D
authors.lastname: Sitkiewicz
authors.forename: A
authors.initials: A
authors.lastname: Pawlik
authors.forename: V
authors.initials: V
authors.lastname: Bielicka-Sulzyc
authors.forename: E
authors.initials: E
authors.lastname: Borowiecka
authors.forename: B
authors.initials: B
authors.lastname: Gawrońska-Szklarz
authors.forename: R
authors.initials: R
authors.lastname: Sterna
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Radziwoń-Zaleska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000235:genetics*; D011044:Poland; D011110:Polymorphism, Genetic
chemical_list: D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D003647:Debrisoquin