Intranigral injected iron progressively reduces striatal dopamine metabolism.
The striatal dopamine metabolism of the rat was followed 1, 3, and 6 weeks after unilateral intranigral iron (III) (50- and 1.5 micrograms) application. For both concentrations a progredient decrease of extraneuronal 3.4-dihydroxyphenylacetic acid (DOPA) levels was observed in the ipsilateral striatum.
Wesemann
W
W
Department of Neurochemistry, Institute of Physiological Chemistry, Marburg, Federal Republic of Germany.
Blaschke
S
S
Solbach
M
M
Grote
C
C
Clement
H W
HW
Riederer
P
P
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005290:Ferric Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D010300:Parkinson Disease / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000187:drug effects*
D005290:Ferric Compounds; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine