[Renal complications from intravenous immunoglobulins. Role of renal hemodynamic factors].
In idiopathic thrombocytopenic purpura, intravenous immunoglobulin therapy is currently a treatment of choice. It is usually effective with little side-effects. Acute renal failure has been recently identified as a potential, though rare, complication of intravenous immunoglobulins. However, the mechanism remains unclear. A 53 year-old-woman with idiopathic thrombocytopenic purpura developed oliguric renal failure after high doses of intravenous immunoglobulins. Her renal function returned to normal after dialysis and plasmapheresis. This rapid normalization suggested that acute renal failure was functional. Since laboratory tests showed an increase in protidemia concomitant to the immunoglobulin therapy, acute renal failure was likely to be related to hyperosmolar renal damage.
Poullin
P
P
Service de Médecine interne, Hôpital de la conception, CHU de Marseille.
Moulin
B
B
Ollier
J
J
Benaicha
M
M
Olmer
M
M
Gabriel
B
B
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D007677:Kidney Function Tests; D008875:Middle Aged; D010956:Plasmapheresis / Q000379:methods; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D006435:Renal Dialysis / Q000379:methods
D016756:Immunoglobulins, Intravenous
Complications rénales des immunoglobulines intraveineuses. Rôle des facteurs hémodynamiques rénaux.