title: [Distribution of alpha 2,3-sialyltransferase mRNA in rat iris and ciliary body].
abstract: The distribution of alpha 2,3-sialyltransferase (alpha 2,3-ST) mRNA in the rat iris and ciliary body was investigated with in situ hybridization histochemistry. Strong expression of alpha 2,3-ST mRNA was detected in the inner epithelial layer of the ciliary body and weak expression in the iris epithelium. Since the synthesis of sialoglycoconjugates is completed by terminal sialylation by the action of sialyltransferase (ST), the ST-expressed portions are considered to produce sialoglycoconjugates. Hence, the source of the sialoglycoconjugates found in the inner epithelial layer of the ciliary body in previous histochemical studies is the same epithelial cell.
authors.affiliation: Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Uehara
authors.forename: N
authors.initials: N
authors.lastname: Ohba
authors.forename: M
authors.initials: M
authors.lastname: Sameshima
authors.forename: K
authors.initials: K
authors.lastname: Unoki
authors.forename: A
authors.initials: A
authors.lastname: Okubo
authors.forename: T
authors.initials: T
authors.lastname: Yanagita
authors.forename: M
authors.initials: M
authors.lastname: Sugata
authors.forename: N
authors.initials: N
authors.lastname: Iwakiri
authors.forename: M
authors.initials: M
authors.lastname: Ozawa
mesh_terms: D000818:Animals; D001483:Base Sequence; D002924:Ciliary Body / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D007498:Iris / Q000378:metabolism*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D012799:Sialyltransferases / Q000235:genetics*; D014018:Tissue Distribution; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
chemical_list: D012333:RNA, Messenger; D012799:Sialyltransferases; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase