title: Nuclear hormone receptors as targets for new drug discovery.
abstract: There are two basic types of receptor transducing systems: those which utilize membrane bound receptors and are activated at the cell surface by the appropriate hormone and transmit their signal to the internae of the cell via a second messenger (i.e. cAMP), and those that utilize internal, cytoplasmic or nuclear receptors (intracellular receptors) which upon activation by hormones interact directly with DNA and alter the genetic program of a cell. This review focuses on the mechanism of action of these intracellular receptors and discusses how such an understanding is expected to facilitate the discovery of new therapeutic agents.
authors.affiliation: Department of Molecular Biology, Ligand Pharmaceuticals Inc., San Diego, CA 92037.
authors.forename: D P
authors.initials: DP
authors.lastname: McDonnell
authors.forename: E
authors.initials: E
authors.lastname: Vegeto
authors.forename: M A
authors.initials: MA
authors.lastname: Gleeson
mesh_terms: D000818:Animals; D001709:Biotechnology; D002467:Cell Nucleus / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011956:Receptors, Cell Surface