title: Tracheal anastomosis with the diode laser and fibrin tissue adhesive: an in vitro and in vivo investigation.
abstract: Absorbable sutures have been advocated for tracheal anastomosis to reduce fibrosis and foreign body reaction leading to recurrent stenosis. Fibrin tissue adhesive (FTA) and diode laser welding with indocyanine green-dyed fibrinogen were evaluated in tracheal anastomosis to reduce the number of sutures and to improve healing. In vitro studies demonstrated strong anastomoses with a combination of laser welding and FTA with minimal tissue damage. In a controlled in vivo study, circumferential resections of canine tracheas were repaired with laser welding and FTA augmented with a few stay sutures. These anastomoses had less fibrosis and tissue damage than anastomoses in control animals repaired with sutures alone. This study supports investigation of laser welding and FTA in human beings for tracheal anastomosis and other procedures in which suturing may be difficult.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Burlington, Mass., USA.
authors.forename: L L
authors.initials: LL
authors.lastname: Gleich
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: M M
authors.initials: MM
authors.lastname: Pankratov
authors.forename: H T
authors.initials: HT
authors.lastname: Aretz
authors.forename: S M
authors.initials: SM
authors.lastname: Shapshay
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D002417:Cattle; D004285:Dogs; D015718:Fibrin Tissue Adhesive; D053685:Laser Therapy; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D013536:Suture Techniques; D014132:Trachea / Q000601:surgery*; D014945:Wound Healing
chemical_list: D015718:Fibrin Tissue Adhesive