European organization for cord blood banking.
Cord blood transplant has been performed in children with malignant and nonmalignant hematological disorders. Most often, the donor was an HLA-identical or a partially mismatched sibling. The results seem to demonstrate that one cord blood contains enough hematopoietic stem cells to reconstitute the marrow in a child, the incidence of graft vs. host disease (GVHD) has been very low in matched transplants, and the immune reconstitution has not been different from a bone marrow transplant. In Paris, seven children have received an HLA-identical sibling cord transplant; five are alive and well, and two had no engraftment. Several questions remain: results in adults, use of cord blood for mis-matched or matched unrelated transplants, standardization of methods of collection, cryopreservation, and banking. A European cord blood banking group has been created to coordinate this research.
Gluckman
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Bone Marrow Transplant Unit-Hôpital Saint-Louis AP HP, University, Paris, France.
D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D001771:Blood Banks / Q000458:organization & administration*; D001772:Blood Cell Count; D001782:Blood Donors; D001793:Blood Preservation; D002648:Child; D002675:Child, Preschool; D002678:Chimera; D015925:Cryopreservation; D004992:Ethics, Medical; D005060:Europe; D005199:Fanconi Anemia / Q000628:therapy; D005312:Fetal Blood / Q000166:cytology; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D012042:Registries; D012189:Retrospective Studies; D016896:Treatment Outcome