Old phage, new insights: two recently recognized mechanisms of transcriptional regulation in bacteriophage T4 development.
The regulation of bacteriophage T4 middle and late gene expression involves previously unrecognized mechanisms. Middle transcription requires a DNA-binding transcriptional activator and a sigma 70-binding co-activator. The coupling of late transcription to DNA replication is effected by a DNA-tracking protein that is loaded onto DNA by an assembly factor at enhancer-like entry sites. Late transcription also requires an RNA polymerase core-binding co-activator. The co-activators of T4 middle and late transcription share the property of depressing unactivated, basal transcription.
Brody
E N
EN
Department of Biological Sciences, State University of New York, Buffalo 14260-1300, USA.
Kassavetis
G A
GA
Ouhammouch
M
M
Sanders
G M
GM
Tinker
R L
RL
Geiduschek
E P
EP
D017122:Bacteriophage T4 / Q000235:genetics* / Q000502:physiology; D001483:Base Sequence; D004261:DNA Replication; D004279:DNA, Viral / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
D004279:DNA, Viral