title: [A non-invasive portable blood-glucose monitoring system: sampling of suction effusion fluid].
abstract: We developed a new portable transcutaneous blood glucose monitoring system using non-invasive collection of suction effusion fluid (SEF) from human skin. A ion sensitive field effect transistor (ISFET) sensor was employed to measure glucose concentration in a very small quantity of the SEF. The system was composed of a couple of portions. One structure was a suction cell, and the other was a main frame. The suction cell included the ISFET glucose sensor, a dilution mechanism, and a sucking interface to human skin. The main frame contained a dilution solution reservoir, a liquid waste reservoir, a fluid pump, a vacuum pump, a micro processor, batteries, and a user interface. The system is self-contained for portable usage during up to 6 hrs monitoring. This system may be the first blood glucose monitoring equipment which does not use blood sampling.
authors.affiliation: Department of Medical Engineering, National Defense Medical College.
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Kayashima
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: A
authors.initials: A
authors.lastname: Kaneyoshi
authors.forename: N
authors.initials: N
authors.lastname: Itoh
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation*; D001826:Body Fluids; D006801:Humans; D012867:Skin; D013396:Suction