[Pressure-independent improvement of aortic distensibility in hypertensive hemodialysed patients].
Hypertensive patients undergoing hemodialysis (HPH) have a marked impairment of their large artery distensibility and an increased cardiovascular morbidity. We investigated twelve HPH (8 males, 4 females, 53 +/- 12 years of age, +/- SD) following a single dose of an ACE inhibitor (quinapril 20 mg) comparatively to a placebo in a randomised cross over study over a week (H0 to H172). We measured repeatedly blood pressure and aortic distensibility (carotid-femoral pulse wave velocity, PWV). Statistical analysis was made through repeated measure ANOVA and repeated measure analysis of covariance because of the tight link between pressure and arterial function. Blood pressure decreased (SAP: p < 0.01, DAP: p < 0.001), and PWV was significantly improved independently of the pressure decrease. ACE inhibitor reduces blood pressure in these patients and improves large arterial function independently of the blood pressure changes.
Pannier
B M
BM
Centre hospitalier F.H. Manhès, Fleury-Mérogis.
Guérin
A P
AP
Marchais
S J
SJ
Cuche
J L
JL
Vicaut
E
E
London
G M
GM
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001011:Aorta / Q000503:physiopathology; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects*; D002985:Clinical Protocols; D003187:Compliance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D000077583:Quinapril; D006435:Renal Dialysis; D044005:Tetrahydroisoquinolines
D000959:Antihypertensive Agents; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077583:Quinapril
Amélioration pression-indépendante de la distensibilité aortique chez l'hémodialysé hypertendu.