Determination of selective biochemical parameters in pregnant and lactating rats after stobadine administration.
The effect of oral administration of stobadine, a cardioprotective drug, was studied on the basis of determination of selective biochemical parameters in pregnant and lactating rats. Stobadine was administered orally at a dose of 50 mg/kg from day 15 of gestation until day 21 of lactation. We determined creatinine and urea in serum, acidity, protein, glucose, ketones, bilirubin, urobilinogen, blood, and creatinine in urine from females on days 15 and 20 of gestation and 7, 14, and 21 of lactation. In the biochemical parameters investigated no significant differences between control and experimental animals were recorded on any of the days studied. Histopathological examination of kidney tissue did not reveal kidney damage after stobadine administration.
Ujházy
E
E
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
Navarová
J
J
Líska
J
J
Balonová
T
T
Vargová
T
T
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000633:toxicity*; D002243:Carbolines / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007774:Lactation / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014508:Urea / Q000097:blood
D000889:Anti-Arrhythmia Agents; D002243:Carbolines; D014508:Urea; D003404:Creatinine; C100106:dicarbine