[An alternative model of structural organization of the ternary complex antigen-protein MHC II-TCR].
An alternative model of organization of the structure of ternary complex "antigen-molecule" of the main complex of histocompatible class II (MHC II)--antigenic receptor of T-cells (TCR) is suggested. In contrast to the already developed ones the new model foresees TCR interaction with only one (beta)-chain of the molecule MHC (II), with its surface site having the structure of alpha-spiral. The second (alpha)-chain of the molecule MHC II performs only antigen-binding and supporting function. According to the structure of the code of amino acids interaction a comparative analysis of the roots (bases of the second nucleotides) of amino acid codons of fragments of alpha-, beta-, and gamma-invariant chains of MHC II, as well as some antigens and immunoregulators. An expressed similarity of the structures of spiral fragment of beta- and gamma-chains of MHC II both between themselves and with certain antigens and natural immunoregulators.
Ievinia
N G
NG
Matveeva
L V
LV
Chipens
G I
GI
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001665:Binding Sites; D000949:Histocompatibility Antigens Class II / Q000737:chemistry*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010446:Peptide Fragments / Q000737:chemistry; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
D000596:Amino Acids; D000949:Histocompatibility Antigens Class II; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell
Al'ternativnaia model' strukturnoĭ organizatsii troĭnogo kompleksa antigen-belok MHC II -TCR.