cDNA cloning of mouse VLA-3 alpha subunit.
cDNA clones for mouse VLA (very late antigen)-3 alpha subunit (alpha 3 integrin) were isolated and sequenced. The encoded mouse alpha 3 integrin subunit was composed of 1,053 amino acid residues. The results of sequence analysis revealed similar structural characteristics of other VLA alpha subunits. For example, the presence of a large extracellular domain including three putative metal binding sequences, a transmembrane domain, and a short cytoplasmic domain. A higher level of its message was detected in thymus than in kidney, stomach, spleen, liver, brain, or lung by Northern blotting analysis.
Takeuchi
K
K
Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Hirano
K
K
Tsuji
T
T
Osawa
T
T
Irimura
T
T
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002461:Cell Line, Transformed; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012333:RNA, Messenger / Q000378:metabolism; D016029:Receptors, Very Late Antigen / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D013539:Simian virus 40
D018076:DNA, Complementary; D046911:Macromolecular Substances; D012333:RNA, Messenger; D016029:Receptors, Very Late Antigen