Hypercalciuria and nephrocalcinosis in patients with idiopathic low-molecular-weight proteinuria in Japan: is the disease identical to Dent's disease in United Kingdom?
Idiopathic low-molecular-weight (LMW) proteinuria is a newly described renal disease in Japan and Italy. We report on 7 patients who manifested bilateral or unilateral nephrocalcinosis, as demonstrated by abdominal computed tomography scans. Renal histology revealed calcinosis of renal tubules in 2 patients. Computed tomography is a reliable method for the detection of nephrocalcinosis in this disorder. Hypercalciuria was also seen in 6 patients. A calcium-loading test performed in 2 patients suggested that hypercalciuria was of renal origin. Although the true pathogenesis is still not known, hypercalciuria and nephrocalcinosis appear to be a common complication in patients with idiopathic LMW proteinuria. These complications and clinical features suggest that idiopathic LMW proteinuria in Japan is likely to be identical to Dent's disease in the United Kingdom.
Igarashi
T
T
Department of Pediatrics, University of Tokyo, Japan.
Hayakawa
H
H
Shiraga
H
H
Kawato
H
H
Yan
K
K
Kawaguchi
H
H
Yamanaka
T
T
Tsuchida
S
S
Akagi
K
K
D000293:Adolescent; D002118:Calcium / Q000008:administration & dosage / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D004591:Electrophoresis, Polyacrylamide Gel; D005198:Fanconi Syndrome / Q000175:diagnosis / Q000652:urine*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D007668:Kidney / Q000166:cytology; D007669:Kidney Calculi / Q000235:genetics; D008297:Male; D009397:Nephrocalcinosis / Q000150:complications* / Q000175:diagnosis / Q000652:urine*; D011507:Proteinuria / Q000150:complications* / Q000652:urine*; D014057:Tomography, X-Ray Computed; D014960:X Chromosome
D002118:Calcium