[The effect of the complement system on the acute reversible rejection of kidney transplants].
Although the involvement of complement in hyperacute renal allograft rejection is well established, its possible implication in acute reversible and chronic graft rejection remains uncertain. In recent clinical studies with a total of 83 patients undergoing renal transplantation, plasma levels of complement activation products were elevated 4-7 days before clinical diagnosis of graft rejection. Immunohistochemical analysis of biopsies revealed local complement activation with glomerular deposition of the terminal C5b-9 complex within 1 h after organ reperfusion. Increasing levels of complement activation products, preceding the clinical manifestation of renal graft rejections may be of diagnostic value in recognizing patients at risk.
Kirschfink
M
M
Institut für Immunologie, Universität Heidelberg.
Wienert
T
T
A Prado
E B
EB
Pomer
S
S
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003174:Complement C1 Inactivator Proteins / Q000378:metabolism; D015926:Complement C3a / Q000378:metabolism; D003165:Complement System Proteins / Q000276:immunology*; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008875:Middle Aged; D013997:Time Factors
D003174:Complement C1 Inactivator Proteins; D015926:Complement C3a; D003165:Complement System Proteins
Zur Bedeutung des Komplementsystems für die akute reversible Abstossungsreaktion von Nierentransplantaten.