[The role of the endogenous opioid system in the mechanisms of the development of early postradiation autonomic and behavioral disorders].
In the experiments with rats and dogs it was shown that irradiation within the dose range of 50-100 Gy is accompanied by the increasing of enkephaline content in various brain structures and beta-endorphine level in blood plasma. The blocking of the opiate receptors naloxone promotes the decrease of post-radiation vomiting in dogs, gastrostasis and hypokinesia in rats. That supports the participation of endogenous opioid system in the primary clinical reaction response to irradiation.
Legeza
V I
VI
Shagoian
M G
MG
Panov
A N
AN
Pshenkina
N I
NI
Buriakova
L V
LV
Turlakov
Iu S
IuS
D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000209:etiology* / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects / Q000528:radiation effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D001923:Brain Chemistry / Q000187:drug effects / Q000528:radiation effects; D002588:Cesium Radioisotopes; D004285:Dogs; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D018847:Opioid Peptides / Q000502:physiology / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D013997:Time Factors; D014916:Whole-Body Irradiation
D002588:Cesium Radioisotopes; D018847:Opioid Peptides; D011957:Receptors, Opioid; D009270:Naloxone
K voprosu o roli éndogennoĭ opioidnoĭ sistemy v mekhanizmakh razvitiia rannikh postluchevykh vegetativnykh i povedencheskikh narusheniĭ.