title: Multifocal Langerhans' cell histiocytosis in a 4-year-old child: a case report.
abstract: A 4-year-old girl presented with pain associated with a mobile mandibular left permanent first molar. The mandibular left primary second molar was also found to be mobile and the gingiva buccal to these teeth was inflamed. A well-defined radioluceny of the left posterior mandible was detected radiographically. Langerhans' cell histiocytosis had been diagnosed 10 months previously when she had presented with an isolated tibial lesion. Curettage of the mandibular lesion and extraction of four adjacent teeth was performed. Post-operatively, radiographic skeletal screening revealed osteolytic lesions in the right parietal bone and right eighth rib. A 6-month course of chemotherapy was instigated which resulted in bony healing of all the osteolytic lesions.
authors.affiliation: Department of Child Dental Health, University of Sheffield, England.
authors.forename: H D
authors.initials: HD
authors.lastname: Rodd
authors.forename: M P
authors.initials: MP
authors.lastname: Gerrard
mesh_terms: D002675:Child, Preschool; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008336:Mandibular Diseases / Q000473:pathology / Q000628:therapy*