[Neuroendocrine response in surgery: comparison between inhalation anesthesia (isoflurane) and intravenous anesthesia (propofol)].
The objectives of the study: 1) comparison between the two anesthesiological techniques both of which were applied to the various surgical groups (patients undergoing emergency surgery for abdominal pathologies and patients undergoing bone marrow biopsy); 2) a comparison between pre- and intraoperative stress levels. The experimental design consists of a comparative survey aimed at ascertaining the existence of statistically significant differences in pre- and intraoperative hormone levels (objective 1) and differences in hormone profiles depending on the anesthesiological technique used (objective 2). Patients were artificially ventilated; intraoperative monitoring included: automatic non-invasive AP every 3 minutes; cardiac monitoring; ETCO2; SaO2; all patients showed a normal postoperative evolution. A total of 30 patients were included in the study (mean age 34 years; ASA 1-3) 14 of which underwent bone marrow biopsy and 16 emergency surgery for abdominal pathologies; patients with hormonal pathologies or receiving treatment with drugs capable of influencing hormone response were excluded from the study.
Filippucci
G
G
USL III, Regione Liguria, Ospedale Regionale S. Martino, Genova.
Raccanelli
L
L
Parodi
A
A
Salmeri
D
D
Bindi
M L
ML
Celentano
R
R
Gamaleri
F
F
Boccignone
E
E
D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D000328:Adult; D000368:Aged; D003687:Dehydroepiandrosterone / Q000032:analysis*; D005260:Female; D013006:Growth Hormone / Q000032:analysis*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D013514:Surgical Procedures, Operative
D003687:Dehydroepiandrosterone; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D007530:Isoflurane; D006854:Hydrocortisone; D015742:Propofol
Risposta neuroendocrina in chirurgia: confronto fra anestesia inalatoria (isoflurane) ed anestesia endovenosa (propofol).