Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers.
The bioavailability of four different Coenzyme Q10 (CoQ) formulations was compared in ten healthy volunteers in a four-way randomised cross-over trial. The included formulations were: A hard gelatin capsule containing 100 mg of CoQ and 400 mg of Emcompress. Three soft gelatin capsules containing: 100 mg of CoQ with 400 mg of soy bean oil (Bioquinon); 100 mg of CoQ with 20 mg of polysorbate 80, 100 mg of lecithin and 280 mg of soy bean oil; and 100 mg of CoQ with 20 mg of polysorbate 80 and 380 mg of soy bean oil, respectively. The result suggests that the soya bean oil suspension of CoQ (Bioquinon has the highest bioavailability. A difference in basic AUC and AUC after p.o. administration of CoQ was observed with respect to sex. A characteristic two peak-pattern was observed at the concentration-time profile.
Weis
M
M
Royal Danish School of Pharmacy, Department of Pharmaceutics, Denmark.
Mortensen
S A
SA
Rassing
M R
MR
Møller-Sonnergaard
J
J
Poulsen
G
G
Rasmussen
S N
SN
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D003067:Coenzymes; D018592:Cross-Over Studies; D005260:Female; D005780:Gelatin; D006801:Humans; D008297:Male; D014677:Pharmaceutical Vehicles; D010713:Phosphatidylcholines; D011136:Polysorbates; D012737:Sex Factors; D013024:Soybean Oil; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D002214:Capsules; D003067:Coenzymes; D014677:Pharmaceutical Vehicles; D010713:Phosphatidylcholines; D011136:Polysorbates; D014451:Ubiquinone; D013024:Soybean Oil; D005780:Gelatin; C024989:coenzyme Q10