title: Brief report: prognostic importance of cellular DNA content in T1-2 N0 laryngeal squamous cell carcinomas treated with radiotherapy.
abstract: One hundred fifty-two unselected, consecutive patients with T1-2N0 laryngeal squamous cell carcinoma received radical radiation therapy at the Division of Radiotherapy, Centro di Riferimento Oncologico, Aviano, Italy. Thirty-one (20.4%) of the patients showed disease recurrence or persistence (R/P) after radiotherapy. Flow-cytometric DNA ploidy measurements were performed in 72 cases; 20 had tumor R/P and 52 did not. Tumor R/P occurred more frequently (in 17 [85%] of 20 cases) in patients with diploid tumors. The hazard ratio of recurrence in diploid tumors as compared with aneuploid tumors, after inclusion of all the other significant prognostic factors in a Cox proportional hazards model, was 8.9 (P < .01). Therefore DNA ploidy seems to be an important marker of tumor R/P in patients with T1-2N0 laryngeal carcinoma after radiotherapy.
authors.affiliation: Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Toffoli
authors.forename: G
authors.initials: G
authors.lastname: Franchin
authors.forename: L
authors.initials: L
authors.lastname: Barzan
authors.forename: C
authors.initials: C
authors.lastname: Cernigoi
authors.forename: A
authors.initials: A
authors.lastname: Carbone
authors.forename: S
authors.initials: S
authors.lastname: Sulfaro
authors.forename: S
authors.initials: S
authors.lastname: Franceschi
authors.forename: M
authors.initials: M
authors.lastname: Boiocchi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics* / Q000532:radiotherapy*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000532:radiotherapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D011003:Ploidies; D011379:Prognosis; D016016:Proportional Hazards Models; D011882:Radiotherapy, High-Energy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004273:DNA, Neoplasm