Expression of mammalian cell-surface receptors in higher eukaryotic systems.
The study of recombinant receptors has progressed rapidly over the past year. These receptors are complex, often multimeric, protein systems. We have seen further progress in the use of mammalian cell lines, but two areas of development in receptor expression are notable: first, increasing use and success of the baculovirus system; and second, improved, rapid methods for detecting signal transduction.
Browne
M J
MJ
Department of Biotechnology, SmithKline Beecham Pharmaceuticals, Welwyn, Hertfordshire, UK.
Balcarek
J M
JM
D000818:Animals; D016367:Baculoviridae / Q000235:genetics; D001709:Biotechnology; D003001:Cloning, Molecular; D015870:Gene Expression; D005822:Genetic Vectors; D006801:Humans; D011956:Receptors, Cell Surface / Q000235:genetics*; D011954:Receptors, Dopamine / Q000235:genetics; D015375:Receptors, Interleukin-2 / Q000235:genetics; D011985:Receptors, Serotonin / Q000235:genetics; D015398:Signal Transduction
D011956:Receptors, Cell Surface; D011954:Receptors, Dopamine; D015375:Receptors, Interleukin-2; D011985:Receptors, Serotonin