title: A general model for the surface glycoproteins of HIV and other retroviruses.
abstract: A hypothetical model of the surface (SU) glycoproteins of human immunodeficiency virus (HIV) and other retroviruses is proposed. The model is based on repetition of a limited number of sequence motifs conserved within the virus family; similarities in biological, immunological, or genetic properties; as well as the tendency for regions of dissimilar sequence to share protein structures predicted by computer algorithms. It is proposed that the protein consists of three structural and functional domains interspersed by relatively conserved interdomain regions. For each retrovirus, these amino-terminal, central, and carboxy-terminal domains may play different roles in binding, postbinding events, and the immune response to viral infection.
authors.affiliation: Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans 70112, USA.
authors.forename: W R
authors.initials: WR
authors.lastname: Gallaher
authors.forename: J M
authors.initials: JM
authors.lastname: Ball
authors.forename: R F
authors.initials: RF
authors.lastname: Garry
authors.forename: A M
authors.initials: AM
authors.lastname: Martin-Amedee
authors.forename: R C
authors.initials: RC
authors.lastname: Montelaro
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006678:HIV / Q000737:chemistry*; D015488:HIV Antigens / Q000737:chemistry*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D012190:Retroviridae / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000737:chemistry*
chemical_list: D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D008562:Membrane Glycoproteins; D014764:Viral Proteins