Antibiotic penetration of experimental intra-abdominal abscesses.
Intra-abdominal abscess is seldom adequately treated by systemic antibiotics alone and often requires surgical or computed tomography-guided drainage for resolution. Abscess penetration of six currently used antibiotics was examined in a murine intra-abdominal abscess model. Ampicillin/sulbactam, cefmetazole, clindamycin, and trospectomycin penetrated intra-abdominal abscesses to a greater degree than cefoxitin and ceftriaxone. Abscess pus antibiotic levels were not significantly higher after multiple doses than after a single dose. Pus antibiotic levels below the MIC90 for Bacteroides and E. coli within intra-abdominal abscess were observed for most antibiotics with the doses used in this study. Selection of antibiotics with a greater ability to penetrate abscess may be important in optimally treating patients with abdominal infection.
Galandiuk
S
S
Department of Surgery, University of Louisville School of Medicine, KY 40292, USA.
Lamos
J
J
Montgomery
W
W
Young
S
S
Polk
H C
HC
D018784:Abdominal Abscess / Q000097:blood / Q000188:drug therapy*; D000667:Ampicillin / Q000493:pharmacokinetics / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001442:Bacteroides Infections / Q000097:blood / Q000188:drug therapy; D001441:Bacteroides fragilis; D015311:Cefmetazole / Q000493:pharmacokinetics / Q000627:therapeutic use; D002440:Cefoxitin / Q000493:pharmacokinetics / Q000627:therapeutic use; D002443:Ceftriaxone / Q000493:pharmacokinetics / Q000627:therapeutic use; D002981:Clindamycin / Q000493:pharmacokinetics / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000097:blood / Q000188:drug therapy; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D000198:Spectinomycin / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D013407:Sulbactam / Q000493:pharmacokinetics / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D015311:Cefmetazole; D002981:Clindamycin; C043267:trospectomycin; D002440:Cefoxitin; D002443:Ceftriaxone; D000667:Ampicillin; D000198:Spectinomycin; D013407:Sulbactam