Senile dementia-Alzheimer's type and estrogen.
Some reports have suggested the ameliorative effects of estrogens on clinical symptoms, such as short memory, in women suffering from senile dementia-Alzheimer's type, in vivo. The action mechanism of estrogen remains to be clarified, but 1) an anti-depressive effect, 2) improvement of cerebral blood flow, 3) direct stimulation of neuron, 4) development of gliacyte and 5) suppression of apolipoprotein E have been suggested. Some mechanisms may be combined, contributing to the beneficial effects on clinical symptoms.
Honjo
H
H
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan.
Tanaka
K
K
Kashiwagi
T
T
Urabe
M
M
Okada
H
H
Hayashi
M
M
Hayashi
K
K
D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism; D003863:Depression / Q000188:drug therapy; D004967:Estrogens / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D014664:Vasodilation
D001057:Apolipoproteins E; D004967:Estrogens