Biochemical properties and biological effects of p53.
Over the past year, insights have been made into the biochemistry and biological effects of p53. The high-resolution three-dimensional structure has been determined for the central core and carboxy-terminal domain of the protein, important p53 target genes (such as WAF1) have been identified, and insight has been gained into the relationship between p53-mediated growth arrest and apoptosis.
Haffner
R
R
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Oren
M
M
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D016158:Genes, p53; D006801:Humans; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
D016159:Tumor Suppressor Protein p53