title: Helicobacter pylori and recurrent ulceration after highly selective vagotomy.
abstract: OBJECTIVE
  To examine the relationship between Helicobacter pylori and recurrent ulceration after highly selective vagotomy (HSV).
  
  
  METHODS
  Academic Department of Surgery at a teaching hospital.
  
  
  METHODS
  Thirty-eight patients (26 men and 12 women) were studied 2-21 years after HSV. Seven patients had recurrent ulceration. Each patient underwent tests of acid secretion before and 1 week after HSV together with later endoscopic examination of the stomach and duodenum. Four biopsies were taken from the duodenum and gastric antrum.
  
  
  RESULTS
  There was no statistical difference in acid output between patients with and those without recurrent ulceration (peak acid output 46.9 versus 55.8 mmol/h, respectively; not significant) before operation. After operation, insulin stimulated acid secretion was significantly higher in patients who later developed recurrent ulceration (0.26 versus 4.1 mmol/h, respectively; P < 0.02). The endoscopic biopsies were tested for H. pylori infection (90 versus 86% for patients without and those with recurrent ulceration, respectively; not significant), gastric metaplasia within the duodenum (23 versus 14% for patients without and those with recurrent ulceration, respectively; not significant), antral gastritis (86 versus 71% for patients without and those with recurrent ulceration, respectively; not significant) and antral intestinal metaplasia (52 versus 43% for those without and those with recurrent ulceration, respectively; not significant).
  
  
  CONCLUSIONS
  H. pylori infection is not influenced by HSV and ulcer recurrence is determined by the completeness of vagotomy rather than by H. pylori status.
authors.affiliation: Academic Department of Surgery, General Infirmary, Leeds, UK.
authors.forename: I G
authors.initials: IG
authors.lastname: Martin
authors.forename: R H
authors.initials: RH
authors.lastname: Diament
authors.forename: M F
authors.initials: MF
authors.lastname: Dixon
authors.forename: A T
authors.initials: AT
authors.lastname: Axon
authors.forename: D
authors.initials: D
authors.lastname: Johnston
mesh_terms: D000328:Adult; D004381:Duodenal Ulcer / Q000382:microbiology / Q000601:surgery*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014629:Vagotomy, Proximal Gastric