Recombinant vaccine development: a novel approach to ectoparasite control. A review of development of a recombinant vaccine for hypodermosis based on hypodermin A.
Cattle grubs (Hypoderma lineatum and H. bovis) are obligate parasites of cattle for most of their one year life cycle. Previously exposed animals become resistant to productive reinfestation, presumably as a result of immune system involvement, suggesting potential control by vaccination. Research progress towards development and utilization of a recombinant subunit vaccine for hypodermosis is described.
Temeyer
K B
KB
Knipling-Bushland U.S. Livestock Insects Research Laboratory, U.S. Department of Agriculture, Kerrville, TX 78028-9184.
Pruett
J H
JH
Kuhn
I
I
Files
J
J
D000818:Animals; D001709:Biotechnology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D004175:Diptera / Q000201:enzymology / Q000276:immunology*; D007000:Hypodermyiasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology; D012697:Serine Endopeptidases / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000302:isolation & purification*
D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic; D012697:Serine Endopeptidases; C030092:hypodermin