title: Severe mitral regurgitation caused by immobile posterior leaflet after radiotherapy.
abstract: Radiotherapy may affect the heart in several ways. We describe a child who had pulmonary edema caused by severe mitral regurgitation after thoracic radiotherapy for a Ewing sarcoma. Transesophageal echocardiography demonstrated this to be caused by an immobilized posterior leaflet, and valve replacement was necessary. This is the first reported patient with rapid progression to severe valvar disease after radiotherapy and in whom this novel mechanism has been demonstrated.
authors.affiliation: Department of Cardiology, University Hospital of Wales, Cardiff, United Kingdom.
authors.forename: R A
authors.initials: RA
authors.lastname: Jones
authors.forename: R J
authors.initials: RJ
authors.lastname: Hall
authors.forename: A G
authors.initials: AG
authors.lastname: Fraser
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D002648:Child; D017548:Echocardiography, Transesophageal; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000528:radiation effects; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D011832:Radiation Injuries / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D012272:Ribs; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000532:radiotherapy; D013997:Time Factors