Iodine distribution in a porcine eye model following iontophoresis.
Iodine distribution was studied in isolated porcine eyes after iontophoresis using 131I-labelled solutions and chemical methods. After a 15-min treatment with a therapeutically used iodine brine, the iodine content in the ocular tissues showed the following rank order: cornea > retina > vitreous body > anterior chamber fluid > lens. Replacement of the brine by 0.15 M NaI increased the uptake values in a different way, but the same rank order was maintained. The increase was highest in the cornea (5.6-fold) and only about 2-fold in the lens, nevertheless approaching now the level of 10(-4) M, a concentration which was regarded as being optimal for the antioxidant effect of I-. Among the other eye components, the relatively high iodine enrichment of the retina was remarkable. The data are discussed with respect to a possible protective, antioxidative and OH-scavenging efficacy of I- and to previous results in the literature concerning iodine uptake in ocular tissues.
Rieger
G
G
Department of Ophthalmology, Paracelsus Institute, Bad Hall, Austria.
Winkler
R
R
Buchberger
W
W
Moser
M
M
D000818:Animals; D005123:Eye / Q000378:metabolism*; D007455:Iodine / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes; D007478:Iontophoresis / Q000379:methods*; D013552:Swine; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D007455:Iodine