title: Developments in high cell density and high productivity microbial fermentation.
abstract: In the past year, new approaches to control high cell density fermentations, molecular strategies coupled with fermentation technology, and updated traditional strategies have been used to overproduce important biological products. The most significant advances include new implementation of control strategies for feeding high cell density fermentations as well as the continued development of alternative Gram-positive bacterial expression systems.
authors.affiliation: Department of Microbiology, Ohio State University, Columbus 43210-1292.
authors.forename: G L
authors.initials: GL
authors.lastname: Kleman
authors.forename: W R
authors.initials: WR
authors.lastname: Strohl
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001685:Biological Factors / Q000096:biosynthesis; D002455:Cell Division; D003470:Culture Media; D005285:Fermentation; D005658:Fungi / Q000254:growth & development* / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000254:growth & development* / Q000378:metabolism; D007218:Industrial Microbiology; D009862:Online Systems; D011994:Recombinant Proteins / Q000096:biosynthesis; D013678:Technology, Pharmaceutical
chemical_list: D000900:Anti-Bacterial Agents; D001685:Biological Factors; D003470:Culture Media; D011994:Recombinant Proteins