Nerve growth factor treatment restores [3H]QNB binding site density in adult rat subjected to cortical infarction.
The effects of unilateral cortical devascularization and nerve growth factor treatment on muscarinic cholinoceptors labelled with [3H]QNB were investigated in rat cerebral cortex. The lesion induced a significant ipsilateral decrease in the density (Bmax) but not in the affinity (kD) of [3H]QNB binding sites. Intraventricular infusion of 2.5 S mouse nerve growth factor (NGF) increased the density of binding sites such that Bmax values of lesioned animals treated with NGF were not different from control subjects.
Liberini
P
P
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Reuben
M
M
Clarke
P B
PB
Cuello
A C
AC
D000818:Animals; D002544:Cerebral Infarction / Q000378:metabolism*; D007839:Functional Laterality / Q000502:physiology; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D011813:Quinuclidinyl Benzilate / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000187:drug effects*; D014316:Tritium
D009414:Nerve Growth Factors; D011976:Receptors, Muscarinic; D014316:Tritium; D011813:Quinuclidinyl Benzilate