title: Studies on growth, spore-forming ability and virulence of the vaccine strain TV-M-310 of the vaccine Bioveta against ringworm.
abstract: We determined the intensity of growth, the ability to form spores and virulence in guinea pigs of the vaccine strain of the Czech live vaccine Bioveta. Comparative investigations were carried out with the vaccine strain of the Russian live vaccine LTF 130 and Trichophyton verrucosum field strains. Growth of the vaccine strains was faster than growth of the field strains on solid media and in broth. Later the vaccine strains formed many microconidia. In experimentally infected guinea pigs the virulence of the vaccine strain Bioveta was highly dependent on the infectious dose. At 10(1) CFU ml-1 (according to the number of CFUs in the Russian live vaccine) the vaccine strain Bioveta was nearly avirulent. Resuspended according to the manufacturer's instructions (at least 10(10) CFU ml-1) virulence of the vaccine strain Bioveta could be observed.
authors.affiliation: Institut für Mikrobiologie und Tierseuchen, Tierärztlichen Hochschule Hannover, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Siesenop
authors.forename: K H
authors.initials: KH
authors.lastname: Böhm
authors.forename: E
authors.initials: E
authors.lastname: Brandebusemeyer
authors.forename: P
authors.initials: P
authors.lastname: Conrad
mesh_terms: D000818:Animals; D002417:Cattle; D005657:Fungal Vaccines; D006168:Guinea Pigs; D013045:Species Specificity; D013172:Spores, Fungal; D014005:Tinea / Q000382:microbiology*; D014249:Trichophyton / Q000254:growth & development* / Q000472:pathogenicity* / Q000502:physiology; D014613:Vaccines, Attenuated; D014774:Virulence
chemical_list: D005657:Fungal Vaccines; D014613:Vaccines, Attenuated