title: Information processing deficits in children with early and continuously treated phenylketonuria?
abstract: Thirty-three patients with early and continuously treated classical phenylketonuria (PKU) and 33 controls matched for age, gender, and educational level of both parents, participated in a chronometric study exploring elementary mechanisms of information processing. Subjects performed speeded performance tasks designed to systematically vary the load on perceptual, central, and output-related mechanisms of information processing. A preliminary analysis of the data indicated that the overall performance of patients with early and continuously treated PKU practically matched that of the controls on all three tasks. Although this finding must be interpreted with caution as it is based on only a preliminary analysis of the data, it suggests that PKU patients who are continuously maintained on a well-controlled phenylalanine-restricted diet are not deficient in the elementary mechanisms of processing. Given the more recent findings indicating that young children with early-treated classical PKU have specific cognitive deficits in the executive function skills, despite relatively strict dietary control, the authors suggest that future studies should focus on these higher-order cognitive processes.
authors.affiliation: Department of Developmental and Experimental Clinical Psychology, State University Groningen, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: Stemerdink
authors.forename: M W
authors.initials: MW
authors.lastname: van der Molen
authors.forename: A F
authors.initials: AF
authors.lastname: Kalverboer
authors.forename: J J
authors.initials: JJ
authors.lastname: van der Meere
authors.forename: M M
authors.initials: MM
authors.lastname: Hendrikx
authors.forename: J
authors.initials: J
authors.lastname: Huisman
authors.forename: L W
authors.initials: LW
authors.lastname: van der Schot
authors.forename: F M
authors.initials: FM
authors.lastname: Slijper
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016022:Case-Control Studies; D002648:Child; D003072:Cognition Disorders / Q000209:etiology* / Q000523:psychology*; D006801:Humans; D008606:Mental Processes; D010661:Phenylketonurias / Q000150:complications* / Q000178:diet therapy / Q000523:psychology; D013997:Time Factors