title: [Prognostic factors in curative resection of stomach carcinoma. A uni- and multivariate analysis].
abstract: The TNM system, including tumor infiltration (T category), lymph node infiltration (N category) and metastasis (M category), is a well-established system of prognostic factors. To evaluate the prognostic importance of patient characteristics and tumor parameters 5 clinical and 13 pathological factors were analyzed. Data on 200 consecutive patients with histologically verified stomach cancer were prospectively recorded using a standardized form. In the subgroup with curative resection (R0, n = 108) a uni- and multivariate analysis was performed with respect to 5-year survival. In the univariate analysis statistical significance was demonstrated for the following factors: tumor size, tumor localization, T category, N category, number of infiltrated lymph nodes infiltrated, lymph node compartments, tumor stage, lymph node ratio: infiltrated/inspected. Multivariate analysis, taking into consideration the interaction between prognostic factors, revealed only two factors as statistically significant: number of infiltrated lymph nodes and tumor size. Our results and those in the literature indicate that the infiltration of lymph nodes is the most relevant prognostic factor. In addition to the TNM system the number of infiltrated lymph nodes seems to be of prognostic importance.
authors.affiliation: Klinik für Allgemein- und Unfallchirurgie, Heinrich-Heine-Universität, Düsseldorf.
authors.forename: J
authors.initials: J
authors.lastname: Gardovskis
authors.forename: O
authors.initials: O
authors.lastname: Horstmann
authors.forename: C
authors.initials: C
authors.lastname: Ohmann
authors.forename: P R
authors.initials: PR
authors.lastname: Verreet
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.forename: R
authors.initials: R
authors.lastname: Wlasak
authors.forename: N
authors.initials: N
authors.lastname: Bösing
authors.forename: F
authors.initials: F
authors.lastname: Borchard
authors.forename: H D
authors.initials: HD
authors.lastname: Röher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D017052:Hospital Mortality; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000401:mortality; D011446:Prospective Studies; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate
vernacular_title: Prognostische Faktoren beim kurativ resezierten Magenkarzinom. Eine uni- und multivariate Analyse.