The changing management of diabetic nephropathy.
The outlook used to be grim: Dipstick-positive proteinuria usually meant that renal failure was inevitable. But now the diagnosis can be made early with the triad of increased kidney size, elevated GFR, and microalbuminuria. Moreover, management that emphasizes strict glycemic control, control of elevated blood pressure, and ACE inhibition can prevent or retard the process.
Dunfee
T P
TP
Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, USA.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000628:therapy*; D018752:Diet, Fat-Restricted; D018753:Diet, Protein-Restricted; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use
D000806:Angiotensin-Converting Enzyme Inhibitors; D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D007004:Hypoglycemic Agents; D000449:Aldehyde Reductase