title: The Hitchner B1 strain of Newcastle disease virus induces high levels of IgA, IgG and IgM in newly hatched chicks.
abstract: Reaseheath line C chicks produced IgA, IgG and IgM in their serum, tears, spleen and Harderian gland (HG) as a consequence of oculotopical vaccination with the Hitchner B1 strain of Newcastle disease virus. The IgM response was seen first, at 5 days after vaccination, and antiviral IgM levels in the tears and serum were negatively correlated to the level of virus in HG over days 4 to 10 postinfection. The frequency of virus-specific IgM-antibody forming cells in the HG of 10-day-old birds that had been vaccinated at 1 day old could reach 1/30th of the total lymphoid cells prepared from the HG. Young chicks made an irregular or low response to inactivated virus by the intravenous route whereas 40-day-old birds made a high serum response to both live and inactivated virus. This emphasizes how day-old chicks respond well to live virus vaccination and that their IgM response is likely to have a role in the clearance of virus.
authors.affiliation: Department of Pathology and Infectious Diseases, Royal Veterinary College, London.
authors.forename: P H
authors.initials: PH
authors.lastname: Russell
authors.forename: G O
authors.initials: GO
authors.lastname: Ezeifeka
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D000831:Animals, Newborn; D002645:Chickens; D006386:Hemagglutination Tests; D007112:Immunity, Maternally-Acquired; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D009522:Newcastle disease virus / Q000276:immunology*; D017186:Titrimetry; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015164:Vaccines, Inactivated; D014765:Viral Vaccines