A model of the pentose phosphate pathway in rat liver cells.
A mathematical model based on kinetic data taken from the literature is presented for the pentose phosphate pathway in fasted rat liver steady-state. Since the oxidative and non oxidative pentose phosphate pathway can act independently, the complete (oxidative+non oxidative) and the non oxidative pentose pathway were stimulated. Sensitivity analyses are reported which show that the fluxes are mainly regulated by D-glucose-6-phosphate dehydrogenase (for the oxidative pathway) and by transketolase (for the non oxidative pathway). The most influent metabolites were the group ATP, ADP, P1 and the group NADPH, NADP+ (for the non oxidative pathway).
Sabate
L
L
Departament de Bioquímica i Fisiologia, Facultat de Química, Universitat de Barcelona, Catalunya, Spain.
Franco
R
R
Canela
E I
EI
Centelles
J J
JJ
Cascante
M
M
D000818:Animals; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008433:Mathematics; D008954:Models, Biological; D010427:Pentose Phosphate Pathway / Q000502:physiology*; D051381:Rats