Bioavailability of labile aluminium in acidic drinking water: a study in the rat.
The bioavailability of labile Al (Allab; Al3+, and monomeric hydroxo and sulfato complexes) in drinking water was studied in the rat. The hypothesis was that Allab in drinking water is more available for absorption in the gastro-intestinal tract than Al complexed in the rat feed. Male Sprague-Dawley rats were exposed to 4 mg Al/litre in acidic drinking water (pH 4-5) and 5 mg Al/kg in the feed for 10 wk. The Al intake of these rats was about twice that in a control group of rats that received Al only in the feed. Both a theoretical speciation calculation and a speciation analysis of the water in a flow injection system showed that more than 98% of the Al in the water was present as Allab. However, intake of this water did not result in increased levels of Al in the bone, liver or brain tissue of the rats. Al speciation in a simulated rat stomach indicated that Allab in drinking water is rapidly complexed by feed constituents as the water enters the acidic milieu of the stomach, resulting in a very low concentration of Allab. The concentration of dissolved Al was also low in comparison to the added amount of labile Al. The possibility of complex formation between Allab and feed components in the gastro-intestinal tract should be taken into account in further studies of the bioavailability of drinking water Al in experimental animals and in humans.
Wicklund Glynn
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A
Swedish National Food Administration, Uppsala.
Sparen
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A
Danielsson
L G
LG
Haegglund
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G
Jorhem
L
L
D000535:Aluminum / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D001835:Body Weight; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D008956:Models, Chemical; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics*
D014874:Water Pollutants, Chemical; D000535:Aluminum