2-oxoglutarate-dependent dioxygenase and related enzymes: biochemical characterization.
Hydroxylation reactions are catalysed by a few major subclasses of enzymes which are ubiquitously distributed in nature. Dioxygenases generally occur as soluble enzymes where they catalyse a diversity of oxygenation reactions in a large number of metabolic pathways in animals, plants and micro-organisms. This review discusses recent advances in the biochemistry and molecular biology of dioxygenases occurring in different biological systems.
De Carolis
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Département de Sciences Biologiques, Université de Montréal, Québec, Canada.
De Luca
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D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D005658:Fungi / Q000201:enzymology; D006801:Humans; D007656:Ketoglutaric Acids / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D010944:Plants / Q000201:enzymology*; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity
D007656:Ketoglutaric Acids; D006899:Mixed Function Oxygenases