title: Histamine synthesis by bone marrow-derived macrophages.
abstract: Histamine may be involved in the regulation of hematopoiesis. However, it remained obscure what kind of cells are responsible for its synthesis in bone marrow (BM). In this study, a pure population of macrophages were raised from BM of W/Wv mice, which are genetically deficient in mast cells. The addition of Escherichia coli lipopolysaccharide (LPS) or murine recombinant granulocyte/macrophage colony-stimulating factor (mrGM-CSF) alone had essentially no effect on histamine synthesis. However, the latter rendered the cells responsive to LPS, leading to a marked increase in HDC-dependent histamine synthesis.
authors.affiliation: Nagoya University BioScience Center, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takamatsu
authors.forename: K
authors.initials: K
authors.lastname: Nakano
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000201:enzymology / Q000378:metabolism*; D001854:Bone Marrow Cells; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006632:Histamine / Q000096:biosynthesis*; D006640:Histidine Decarboxylase / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D006632:Histamine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006640:Histidine Decarboxylase