Paradoxical phase response at late expiration by superior laryngeal nerve stimulation.
Superior laryngeal nerve (SLN) stimulation during expiration prolongs the respiratory cycle in decerebrate, vagotomized and paralysed cats. In a few animals, however, the cycle can be terminated prematurely by the same stimulus. We developed a mathematical model of the respiratory neural network to stimulate these responses. The model contained inspiratory decrementing (I-DEC), and augmenting (I-AUG) and expiratory decrementing (E-DEC), and augmenting (E-AUG) neurones. Connections were based on published findings. SLN stimulation during late expiration prolonged the cycle when it was assumed to excite principally E-DEC neurones, whereas it terminated the cycle prematurely when it was assumed to excite both I-DEC and E-DEC neurones. Therefore, phase-resetting depends on the differential strength of afferent connections on the network's elements.
Oku
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Department of Clinical Physiology, Kyoto University, Japan.
Dick
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TE
D000818:Animals; D002415:Cats; D003655:Decerebrate State; D004558:Electric Stimulation; D007823:Laryngeal Nerves / Q000502:physiology*; D008433:Mathematics; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*; D013997:Time Factors