title: Histological evidence for neuroprotective action of nebracetam on ischemic neuronal injury in the hippocampus of stroke-prone spontaneously hypertensive rats.
abstract: The protective effect of nebracetam on ischemic neuronal damage was histologically examined in the pyramidal cell layer of the hippocampal CA1 subfield 7 days after operation using stroke-prone spontaneously hypertensive rats (SHRSP) subjected to 10-min bilateral carotid occlusion. Nebracetam (50 and 100 mg/kg), given orally 10 min after reperfusion, dose-dependently protected against ischemic delayed neuronal damage in the SHRSP with occlusion; however, the blood pressure remained unchanged following nebracetam administration. These findings further support the notion that nebracetam protects against ischemic delayed neuronal cell death in the hippocampus.
authors.affiliation: Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
authors.forename: M N
authors.initials: MN
authors.lastname: Nakashima
authors.forename: Y
authors.initials: Y
authors.lastname: Kataoka
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Kohzuma
authors.forename: M
authors.initials: M
authors.lastname: Ichikawa
authors.forename: M
authors.initials: M
authors.lastname: Niwa
authors.forename: Y
authors.initials: Y
authors.lastname: Kohno
authors.forename: K
authors.initials: K
authors.lastname: Taniyama
mesh_terms: D000818:Animals; D002545:Brain Ischemia; D002452:Cell Count / Q000187:drug effects; D006624:Hippocampus; D006973:Hypertension; D008297:Male; D018696:Neuroprotective Agents; D010277:Parasympathomimetics / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000166:cytology; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D018696:Neuroprotective Agents; D010277:Parasympathomimetics; D011760:Pyrrolidinones; C056640:nebracetam