Polysaccharide (ANK-102) from Polianthes tuberosa cells deteriorates the resistance of mice to Listeria monocytogenes infection.
Modulatory effect on the murine self defense system by a newly discovered acidic polysaccharide (ANK-102) produced by P. tuberosa cells in liquid culture was examined. Pretreatment with ANK-102 deteriorated the murine survival against lethal infection of Listeria monocytogenes, an intracellular gram-positive bacterium eliminated mainly by macrophages through T-cell mediated immune response. Pretreatment with ANK-102 resulted in the accumulation of Mac 1 and Mac 2 positive cells in the peritoneal cavity of the infected animals and the reduction of Thy1.2 expression on the surface of the thymocytes. A new type of immunosuppressive polysaccharide ANK-102 was introduced.
Majima
T
T
Department of Ontogeny and Development, Tohoku University, Sendai, Japan.
Otsuji
K
K
Nagatomi
R
R
Konno
T
T
D000818:Animals; D001431:Bacteriological Techniques; D007113:Immunity, Innate / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007912:Lentinan / Q000633:toxicity; D008089:Listeria monocytogenes / Q000187:drug effects / Q000254:growth & development; D008088:Listeriosis / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011134:Polysaccharides / Q000633:toxicity*
D007166:Immunosuppressive Agents; D011134:Polysaccharides; D007912:Lentinan