title: Hyperendemic penicillinase-producing Neisseria gonorrhoeae genital infections in an inner city population.
abstract: OBJECTIVE
  To determine: 1) the proportion of Neisseria gonorrhoeae caused by penicillinase-producing Neisseria gonorrhoeae (PPNG) in our inner-city population; 2) any difference in the isolation rates of PPNG between adolescents and adults; 3) co-infection rates with Chlamydia trachomatis in this adolescent population; and 4) the appropriateness of current CDC recommendations for initial treatment of patients with suspected gonococcal infection.
  
  
  METHODS
  Genital cultures for GC were obtained from 1990 patients seen in the emergency room or primary care clinics. Of these, 285 were adolescents between 12 and 19 years of age. All adolescent patients were tested for chlamydial infection. Comparisons of gonococcal infection rates were made between adults and adolescents and between males and females. The rates of symptomatic versus asymptomatic adolescents were compared.
  
  
  RESULTS
  Genital cultures were positive for GC in 13% of the patients tested. Of these, 51% were identified as being caused by PPNG. Among the adolescents, cultures were positive in 25%, and 63% of these were identified as PPNG. The rate of PPNG was significantly higher in adolescents than in adults. The rate of PPNG was highest in adolescent females and lowest in adult males. There was no difference in the rate of PPNG between adolescents and adult males. Of the 71 adolescents with GC, 58% were coinfected with C. trachomatis. Adolescents with PPNG had a higher rate of concomitant infection with C. trachomatis than those with a penicillin-sensitive strain. Adolescents with N. gonorrhoeae were more likely to be infected with PPNG if they had GU symptoms.
  
  
  CONCLUSIONS
  Our data supports the most recent CDC recommendations that the initial treatment for suspected N. gonorrhoeae be effective against PPNG. Furthermore, chlamydia screening and treatment is warranted in patients suspected of having an STD.
authors.affiliation: Department of Pediatrics, Brookdale Hospital Medical Center, New York, USA.
authors.forename: W M
authors.initials: WM
authors.lastname: Seigel
authors.forename: N H
authors.initials: NH
authors.lastname: Golden
authors.forename: S
authors.initials: S
authors.lastname: Weinberg
authors.forename: I M
authors.initials: IM
authors.lastname: Sacker
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002690:Chlamydia Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D005832:Genital Diseases, Male / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D006069:Gonorrhea / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000201:enzymology / Q000302:isolation & purification; D009519:New York City / Q000453:epidemiology; D010405:Penicillinase / Q000096:biosynthesis; D012737:Sex Factors; D014505:Urban Population
chemical_list: D010405:Penicillinase