TLC of p-nitroanilines and their analogues with cyclodextrins in the mobile phase.
The addition of alpha-, beta-, gamma-, and hydroxypropyl-beta-cyclodextrins to aqueous mobile phases can be used to enhance the migration of p-nitroanilines and their analogues on thin-layer chromatography. Urea, which is used to solubilize the cyclodextrins in aqueous solutions, is also found to increase the migration of these compounds. The equilibrium binding constants for the solute-cyclodextrin complexes formed in the mobile phase are determined. The results obtained using either silica gel or polyamide plates are similar.
Politzer
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IR
Department of Chemistry, Xavier University of Louisiana, New Orleans 70125, USA.
Crago
K T
KT
Hollin
T
T
Young
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M
D000814:Aniline Compounds / Q000737:chemistry / Q000302:isolation & purification*; D002855:Chromatography, Thin Layer; D003505:Cyclodextrins / Q000737:chemistry; D015394:Molecular Structure; D014508:Urea
D000814:Aniline Compounds; D003505:Cyclodextrins; C019498:4-nitroaniline; D014508:Urea