[A cytogenetic study of patients with disordered thyroid homeostasis].
The cytogenetic disturbances in peripheral blood lymphocytes from patients with various thyroid diseases were studied. It was found that hormone administration results in chromosome aberration and micronucleus (MN) rate increase. The changes in the chromosome aberration spectrum correspond with radiation induced changes in the spectrum. The additional irradiation of cells in vitro caused the lower level of MN in patients treated with hormones than in control donors group.
Raketskaia
V V
VV
Evtushenko
T P
TP
Dubko
O V
OV
Koliubaeva
S N
SN
Komar
V E
VE
D001782:Blood Donors; D002478:Cells, Cultured; D002588:Cesium Radioisotopes; D002869:Chromosome Aberrations; D003131:Combined Modality Therapy; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D015162:Micronucleus Tests; D013959:Thyroid Diseases / Q000097:blood / Q000235:genetics* / Q000628:therapy; D013997:Time Factors
D002588:Cesium Radioisotopes
Tsitogeneticheskoe issledovanie bol'nykh s narusheniem tireoidnogo gomeostaza.