title: Conformational analysis and biological activity of leptocarpin and leptocarpin acetate.
abstract: This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition of [35S]-methionine uptake without affecting the (methyl-3H)thymidine and (5,6-3H)uridine incorporation, when assayed in HeLa cells.
authors.forename: R
authors.initials: R
authors.lastname: Martínez
authors.forename: V
authors.initials: V
authors.lastname: Kesternich
authors.forename: E
authors.initials: E
authors.lastname: Gutierrez
authors.forename: H
authors.initials: H
authors.lastname: Dölz
authors.forename: H
authors.initials: H
authors.lastname: Mansilla
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D002236:Carbohydrate Conformation; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes; C093535:leptocarpin acetate; C093534:leptocarpin; D015107:4-Butyrolactone