title: Midazolam reduces vomiting after tonsillectomy in children.
abstract: The purpose of this study was to assess the effect of midazolam on vomiting after tonsillectomy in children. We compared 215 children aged 1.5-14 yr undergoing tonsillectomy or adenotonsillectomy under general anaesthesia with nitrous oxide and halothane. In a double-blind fashion the subjects were administered either placebo or midazolam 75 micrograms.kg-1 iv after induction of anaesthesia. After the operation, the number of emetic episodes and the length of stay in hospital were recorded. The groups were similar with respect to age, weight, sex, mode of induction, duration of anaesthesia, surgical procedure, opioid administration and length of stay in the PAR and the Day Care Surgical Unit. The 108 midazolam-treated children had a lower incidence (42% vs 57%) of vomiting than the placebo group, P < 0.02. The placebo group had a higher incidence (9% vs 2%) of unscheduled admissions to hospital due to nausea and vomiting, P < 0.05. It is concluded that midazolam administered intravenously to children intraoperatively reduces vomiting after tonsillectomy.
authors.affiliation: Department of Anaesthesia, University of Ottawa, Ontario, Canada.
authors.forename: W M
authors.initials: WM
authors.lastname: Splinter
authors.forename: H B
authors.initials: HB
authors.lastname: MacNeill
authors.forename: E A
authors.initials: EA
authors.lastname: Menard
authors.forename: E J
authors.initials: EJ
authors.lastname: Rhine
authors.forename: D J
authors.initials: DJ
authors.lastname: Roberts
authors.forename: M H
authors.initials: MH
authors.lastname: Gould
mesh_terms: D000233:Adenoidectomy / Q000009:adverse effects; D000293:Adolescent; D000556:Ambulatory Surgical Procedures; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007902:Length of Stay; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D011292:Premedication; D014068:Tonsillectomy / Q000009:adverse effects*; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D010919:Placebos; D008874:Midazolam