Inhibitory activity of anti-beta 2-glycoprotein I antibody on factor Va degradation by activated-protein C and its cofactor protein S.
We investigated the influence of anti-beta 2-glycoprotein I (aGPI), which recently has come to be regarded as anti-cardiolipin antibody (aCL) itself, on factor Va (FVa) degradation by activated protein C/protein S system. We found that aGPI had an inhibitory effect on FVa degradation with beta 2-glycoprotein I-dependency, thus suggesting aGPI/aCL is a highly possible factor as the pathogenesis of thrombosis observed in aGPI/aCL-positive patients.
Matsuda
J
J
Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Gohchi
K
K
Kawasugi
K
K
Gotoh
M
M
Saitoh
N
N
Tsukamoto
M
M
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D015943:Factor Va / Q000378:metabolism*; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007700:Kinetics; D011486:Protein C / Q000378:metabolism*; D017293:Protein S / Q000378:metabolism*; D011817:Rabbits / Q000276:immunology; D053482:beta 2-Glycoprotein I
D000906:Antibodies; D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D053482:beta 2-Glycoprotein I; D015943:Factor Va