Coenzyme Q10 levels, plasma lipids and peroxidation extent in renal failure and in hemodialytic patients.
Coenzyme Q10 (CoQ10), vitamin E, triglycerides and conjugated dienes were measured in a group of 48 patients on chronic hemodialysis, in 15 uremic patients and in a control group of 10 normal subjects. CoQ10 levels were significantly lower (P < 0.001) in both hemodialytic and uremic patients compared with the normal group whereas triglycerides were significantly higher (P < 0.001) with respect to both normal subjects and uremic patients. Conjugated dienes were significantly higher (P < 0.001) in both hemodialytic and uremic patients with respect to normal subjects. The predialytic values of vitamin E were higher in hemodialytic patients with respect to both normal subjects and uremic patients whereas the postdialytic values were in the normal range. A restoration mechanism of vitamin E after hemodialytic treatment was hypothesized.
Lippa
S
S
Istituto di Chimica e Chimica Clinica, Università Cattolica del S. Cuore.
Colacicco
L
L
Callà
C
C
Sagliaschi
G
G
Angelitti
A G
AG
D000328:Adult; D000368:Aged; D003067:Coenzymes; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014511:Uremia / Q000097:blood / Q000628:therapy; D014810:Vitamin E / Q000097:blood*
D003067:Coenzymes; D008055:Lipids; D014280:Triglycerides; D014451:Ubiquinone; D014810:Vitamin E; C024989:coenzyme Q10