title: A nested case-control study on the association between Helicobacter pylori infection and gastric cancer risk in a cohort of 9775 men in Taiwan.
abstract: A nested case-control study was carried out to investigate the association between Helicobacter pylori infection and gastric cancer risk in Taiwan. A total of 29 patients newly affected with gastric cancer and 220 healthy controls matched with cases on age, sex and residence were selected from a cohort of 9,775 men recruited from 1984 through 1986. Frozen serum samples collected at recruitment examination were tested for IgG antibodies against Helicobacter pylori by an enzyme-linked immunosorbent assay. The average interval between serum collection and cancer diagnosis was 3.1 years. Gastric cancer cases had a higher seropositive prevalence (69%) than matched controls (59%) giving an odds ratio of 1.6 (95%) confidence interval = 0.7-2.6). Compared with previous nested case-control studies, Helicobacter pylori infection in early childhood may be a risk factor for gastric cancer. However, a long induction period seems required for gastro-carcinogenesis associated with Helicobacter pylori infection.
authors.affiliation: Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei.
authors.forename: J T
authors.initials: JT
authors.lastname: Lin
authors.forename: L Y
authors.initials: LY
authors.lastname: Wang
authors.forename: J T
authors.initials: JT
authors.lastname: Wang
authors.forename: T H
authors.initials: TH
authors.lastname: Wang
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003043:Cocarcinogenesis; D015331:Cohort Studies; D015897:Comorbidity; D005756:Gastritis / Q000097:blood / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012306:Risk; D016036:Seroepidemiologic Studies; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000382:microbiology; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G