Human parvovirus B19 can infect cynomolgus monkey marrow cells in tissue culture.
The human pathogenic parvovirus B19 cannot be grown in standard tissue culture but propagates in human bone marrow, where it is cytotoxic to erythroid progenitor cells. We now show that parvovirus B19 can replicate in cynomolgus bone marrow. Cynomolgus monkeys may be a suitable animal model for pathogenesis studies of parvovirus B19.
Gallinella
G
G
Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Anderson
S M
SM
Young
N S
NS
Brown
K E
KE
D000818:Animals; D001853:Bone Marrow / Q000821:virology*; D001854:Bone Marrow Cells; D046508:Culture Techniques; D004261:DNA Replication; D004279:DNA, Viral / Q000032:analysis / Q000096:biosynthesis; D008252:Macaca fascicularis; D016732:Parvovirus B19, Human / Q000472:pathogenicity* / Q000502:physiology; D014779:Virus Replication
D004279:DNA, Viral