[Transplacental transfer of stobadine in rabbits in various stages of pregnancy--an approximation using a pharmacokinetic model].
Stobadine (STB), a cardioprotective drug, was investigated for its placental transfer in rabbits on the 20th and 27th day of gestation. The concentration of 3H-STB and its metabolites was determined in maternal and foetal plasma and organs at 0.5; 1; 2; and 6 h after the oral administration of 5 mg/kg STB. The third and fifth order linear models were selected as the optimal models of the fate of STB in the maternal plasma at the 20th and 27th day of gestation, respectively. The high order of the latter model indicated recirculation of STB in the maternal body at the last stage of gestation. The concentrations of STB and its metabolites in the uterus were found to be higher at mid- than late-pregnancy. At the 27th day of pregnancy the concentration of STB and its metabolites were higher in all foetal organs than on the concentrations at the 20th day of pregnancy, indicating active placental barrier function in mid-pregnancy.
Ujházy
E
E
Ustav experimentálnej farmakológie SAV, Bratislava.
Faberová
V
V
Dubovický
M
M
Zemánek
M
M
Jansák
J
J
Dedík
L
L
Durisová
M
M
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D002243:Carbolines / Q000493:pharmacokinetics*; D005260:Female; D005333:Fetus / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011817:Rabbits; D014599:Uterus / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D002243:Carbolines; C100106:dicarbine
Transplacentárny prechod stobadínu u králikov v rôznych stádiach gravidity--aproximácia farmakokinetickým modelom.