Use of a digestive mucosal graft in urethroplasty. An experimental study--prospective utilization of the appendix mucosa.
Colic mucosa was used as a graft for urethral construction in 9 Sprague-Dawley rats. A urethrectomy was performed in each rat and then a urethroplasty built with the colic mucosa taken from a segmental colectomy. After 6 weeks to 3 months, all of these rats developed a typical urothelium. The digestive mucosa has been transformed into urothelium or acts as a stent to guide regrowth from each end. These results are encouraging, but the use of the appendix mucosa for hypospadias repair and for urethroplasty deserves further study.
Lebret
T
T
Department of Pediatric Surgery, University of Rouen, Charles Nicolle Hospital, France.
Gobet
F
F
Dallaserra
M
M
Mitrofanoff
P
P
D000818:Animals; D001065:Appendix; D003106:Colon; D004195:Disease Models, Animal; D005260:Female; D007021:Hypospadias / Q000601:surgery; D007413:Intestinal Mucosa / Q000637:transplantation*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014521:Urethra / Q000473:pathology / Q000601:surgery*