title: Changing pattern of pathogens causing broviac catheter-related bacteraemias in children with cancer.
abstract: The incidence of pathogens causing catheter-related bacteraemias in children undergoing antineoplastic chemotherapy with or without bone marrow transplantation at G. Gaslini Children's Hospital, Genoa, Italy, was analysed by comparing data from a retrospective study (1985-1988) with that obtained from a prospective one (1989-1992). In both periods catheter-related bacteraemias one (1989-1992). In both periods catheter-related bacteraemias were more frequent in non-neutropenic than in neutropenic patients. Among catheter-unrelated bacteraemias the pattern of infecting pathogens remained unchanged between the study periods, with Gram-positive bacteria remaining the predominant pathogens. Conversely, among catheter-related bacteraemias, the incidence of Gram-negative bacilli increased significantly from 3 to 38%, and that of Gram-positive bacteria fell from 63 to 32% (P = 0.001, chi 2 test for heterogeneity.
authors.affiliation: Department of Infectious Diseases, G. Gaslini Children's Hospital, Genoa, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Castagnola
authors.forename: A
authors.initials: A
authors.lastname: Garaventa
authors.forename: C
authors.initials: C
authors.lastname: Viscoli
authors.forename: G
authors.initials: G
authors.lastname: Carrega
authors.forename: M
authors.initials: M
authors.lastname: Nantron
authors.forename: C
authors.initials: C
authors.lastname: Molinari
authors.forename: C
authors.initials: C
authors.lastname: Moroni
authors.forename: R
authors.initials: R
authors.lastname: Giacchino
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002408:Catheters, Indwelling / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology*; D005658:Fungi / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007558:Italy; D009369:Neoplasms / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D000970:Antineoplastic Agents