title: Abortive and subclinical poliomyelitis in a family during the 1992 epidemic in The Netherlands.
abstract: We describe a case of abortive poliomyelitis due to poliovirus type 3 (PV3) in an unvaccinated woman and a subclinical poliovirus infection in her family during an epidemic in the Netherlands. The woman excreted the epidemic strain (PV3) for 7 weeks. Her two children received oral attenuated poliovirus vaccine and were subsequently found to excrete PV1 and PV2 vaccine strains in addition to the epidemic PV3 strain. Her husband, who had neutralizing antibodies to all three poliovirus types because of previous vaccination, initially excreted no virus; subsequently, however, the vaccine strain PV1 and the epidemic strain PV3 could be cultured from his feces. These observations demonstrate the ease with which poliovirus circulates among family members, including those with neutralizing antibodies.
authors.affiliation: Department of Infectious Diseases, University Hospital Leiden, The Netherlands.
authors.forename: F P
authors.initials: FP
authors.lastname: Kroon
authors.forename: H T
authors.initials: HT
authors.lastname: Weiland
authors.forename: A M
authors.initials: AM
authors.lastname: van Loon
authors.forename: R
authors.initials: R
authors.lastname: van Furth
mesh_terms: D000328:Adult; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011051:Poliomyelitis / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D017955:Poliovirus / Q000302:isolation & purification; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage
chemical_list: D011055:Poliovirus Vaccine, Oral