title: A pilot study of cyclosporine for the prevention of postsurgical adhesion formation in rats.
abstract: OBJECTIVE
  Our purpose was to evaluate the efficacy of cyclosporine in preventing primary postsurgical adhesions in the rat model.
  
  
  METHODS
  Thirty-two Sprague-Dawley rats underwent unilateral uterine horn injury with a combination of unipolar and bipolar cautery. Sixteen of the rats were randomized to the treatment group and received preoperative and daily cyclosporine dosing (10 mg/kg) by gavage for 14 days. At the end of the study all animals were killed, and a standard adhesion scoring system was applied by a blinded examiner.
  
  
  RESULTS
  Adhesions were present in 75% of rats in both groups. Treatment did not affect the total adhesion score.
  
  
  CONCLUSIONS
  Cyclosporine does not appear promising as a means to decrease postsurgical adhesion formation.
authors.affiliation: Department of Obstetrics and Gynecology, Maine Medical Center, Portland 04102, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Leondires
authors.forename: P G
authors.initials: PG
authors.lastname: Stubblefield
authors.forename: H M
authors.initials: HM
authors.lastname: Tarraza
authors.forename: M A
authors.initials: MA
authors.lastname: Jones
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control; D014591:Uterine Diseases / Q000517:prevention & control*
chemical_list: D016572:Cyclosporine