Secondary hyperparathyroidism and nonmedullary thyroid cancer.
Nonmedullary thyroid carcinoma is known to occur in association with primary hyperparathyroidism. A combination of secondary, uremic, hyperparathyroidism and non-medullary thyroid carcinoma is rare and was hitherto reported in only 12 cases. We report another three patients with this parathyroid/thyroid disease combination, suggesting that it may represent not merely a coincidence. A number of factors active in secondary hyperparathyroidism may play a role in the induction and/or promotion of the thyroid cancer. These include parathyroid endocrinopathy, goiterogenic effect of prolonged hypercalcemia, and uremia. During surgery on the parathyroid glands, associated thyroid lesions demand special considerations.
Nash
E
E
Department of Surgery, Bnai Zion Medical Center, Haifa, Israel.
Eldar
S
S
Shajrawi
I
I
Abrahamson
J
J
Schein
M
M
D000230:Adenocarcinoma / Q000150:complications; D000328:Adult; D002291:Carcinoma, Papillary / Q000150:complications; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000150:complications*