[Bone mineral quantifying of methods in hyperparathyroidism].
Bone mineral densities (BMDs) in both cortical and trabecular bone decrease in primary hyperparathyroidism (PHP) and renal hyperparathyroidism (RHP). Bone mineral parameters in the second metacarpal bone were studied by digital image processing method (DIP). Lumbar BMD (L-BMD) and mid-radial BMD (R-BMD) were measured by dual energy X-ray absorptiometry (DXA). All indexes of bone mass at all measured sites in both PHP and RHP were significantly lower than normal those in controls. The decrease in appendicular BMD was more remarkable than that in LBMD. After parathyroidectomy (PTX), all indexes of bone mass with the exception of the MCI increase especially, in L-BMD. This discrepancy in dicates that PTH affects cortical bone and trabecular bone in dependently. Mild and moderate oversecretion of PTH has an anabolic effect, while a high of PTH has a catabolic effect on trabecular bone. The quantification of bone minerals is useful in follow-up studies and evaluation of the therapeutical response in hyperparathyroidism.
Imai
H
H
Department of Orthopaedic Surgery, Kawasaki Medical School.
Katagiri
M
M
D015502:Absorptiometry, Photon / Q000379:methods; D015519:Bone Density; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis*