Nonlinear relationship between erythrocyte sodium-lithium countertransport and blood pressure in man.
A relationship between erythrocyte Na+/Li(+)-countertransport activity and blood pressure was studied in a randomly selected sample (95 subjects) with full range of blood pressure, from a representative group of inhabitants of one of Moscow's districts. The mean rate of erythrocyte Na+/Li(+)- countertransport activity was higher (p < 0.01 or less) in the groups of subjects with both borderline (BH) and moderate essential hypertension (EH) as compared with the group of normotensives (NT). A positive correlation was found between the erythrocyte Na+/Li(+)- countertransport rate and age and body weight in the entire selected group. The total contribution of these confounding parameters is responsible for 20.4% of the interindividual variability of the Na+/Li(+)- countertransport activity. The individual Na+/Li(+)- countertransport values remained unchanged during at least 2 years of follow-up. A nonlinear relationship between erythrocyte Na+/Li(+)- countertransport activity and blood pressure was established in the entire group. No significant association between blood pressure and Na+/Li(+)- countertransport was seen at high and low values of these two parameters. A pronounced change in the erythrocyte Na+/Li(+)- countertransport values occurred within a narrow borderline blood pressure range.
Petrov
V V
VV
Cardiology Research Centre, Moscow, Russia.
Britov
A N
AN
Levitsky
D O
DO
Minchenko
B I
BI
Konstantinov
E N
EN
Svidersky
V D
VD
Novikov
I D
ID
Grishenkov
E A
EA
Lijnen
P J
PJ
D000328:Adult; D000704:Analysis of Variance; D001693:Biological Transport, Active; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D008094:Lithium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012426:Russia; D012964:Sodium / Q000097:blood*
D008094:Lithium; D012964:Sodium