[The pharmacokinetic optimization of depakin in children with epilepsy].
Effective application of anticonvulsants is among the main problems of conservative management of epilepsy in children. Pharmacokinetics of two anticonvulsants, depakin and convulex, was studied in 33 epileptic patients. Its description, based on a mathematical model, permits selection of doses and frequency of administration so that concentration of the drug remains within the therapeutical range as long as possible. Introduction of methods of analysis of individual pharmacokinetics of anticonvulsants enhances efficacy of treatment by 30 per cent in children with epileptic attacks.
Shamansurov
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D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000097:blood / Q000188:drug therapy*; D004829:Epilepsy, Generalized / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D014635:Valproic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000927:Anticonvulsants; D014635:Valproic Acid
Farmakokineticheskaia optimizatsiia depakina u deteĭ s épilepsieĭ.