title: [Individualized therapy with alpha-interferon in metastatic renal cell carcinoma].
abstract: Thirty-two patients with metastatic renal cell carcinoma were treated as outpatients with individually dosed interferon alpha (IFN alpha). The individual maximum dose was based on the side effects. In 7 patients the course of the disease was influenced: 1 attained complete remission, 3 patients, partial remission and 3, stable disease. The outcome of therapy was not dose-dependent. Patients with lung metastases were more sensitive to IFN alpha than the others. Up to 20% of patients responded to the therapy.
authors.affiliation: Klinik für Urologie, Klinikum Steglitz der FU Berlin.
authors.forename: A J
authors.initials: AJ
authors.lastname: Gross
authors.forename: K P
authors.initials: KP
authors.lastname: Dieckmann
authors.forename: J
authors.initials: J
authors.lastname: Krain
authors.forename: H
authors.initials: H
authors.lastname: Huland
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000009:adverse effects; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009392:Nephrectomy; D016896:Treatment Outcome
chemical_list: D016898:Interferon-alpha
vernacular_title: Individualspezifische Therapie mit alpha-Interferon beim metastasierten Nierenzellkarzinom.