title: Interim results on a randomized trial of mitomycin C in combination with orchidectomy for newly diagnosed metastatic prostate cancer.
abstract: The interim results of a randomized trial comparing orchidectomy alone versus orchidectomy and mitomycin C in 178 newly diagnosed metastatic prostate cancer patients are presented. Of 148 evaluable patients 75 were treated with orchidectomy alone and 73 received adjuvant intravenous mitomycin C. Mean time to progression was 15 months in the orchidectomy group versus 14 months in the mitomycin C group. Interim analysis did not demonstrate a favorable effect of the combination with this chemotherapeutic agent compared to orchidectomy alone (P = .45).
authors.affiliation: Department of Urology, Radiotherapy and Oncology, University Hospitals K. U. Leuven, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Vandenbroucke
authors.forename: H
authors.initials: H
authors.lastname: Van Poppel
authors.forename: J
authors.initials: J
authors.lastname: Derluyn
authors.forename: G
authors.initials: G
authors.lastname: Popelier
authors.forename: J
authors.initials: J
authors.lastname: Casselman
authors.forename: I
authors.initials: I
authors.lastname: Billiet
authors.forename: L
authors.initials: L
authors.lastname: Vanuytsel
authors.forename: R
authors.initials: R
authors.lastname: Paridaens
authors.forename: L
authors.initials: L
authors.lastname: Baert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis
chemical_list: D016685:Mitomycin