Effect of corticosteroids on survival of children with acquired immunodeficiency syndrome and Pneumocystis carinii-related respiratory failure.
The medical records of patients with acquired immunodeficiency syndrome were reviewed to evaluate the effect of our adoption to the pediatric population of the National Institutes of Health recommendation for adjunctive corticosteroid therapy in adults with Pneumocystis carinii pneumonia. In 21 episodes of P. carinii-related respiratory failure, only adjunctive corticosteroids were associated with a significant improvement in survival to successful removal of the tracheal tube, from a historical rate of 11% to 91%.
McLaughlin
G E
GE
Department of Pediatrics, University of Miami School of Medicine, Florida 33101, USA.
Virdee
S S
SS
Schleien
C L
CL
Holzman
B H
BH
Scott
G B
GB
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000401:mortality / Q000628:therapy*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000208:Acute Disease; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D007442:Intubation, Intratracheal; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000401:mortality / Q000628:therapy*; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents