Mechanisms in adverse reactions to food. The skin.
Ingested food antigens rapidly cross the gastrointestinal barrier and reach pro-inflammatory cells in the skin. Food allergy provokes urticaria/angioedema by classical, Type I, IgE-mediated hypersensitivity. Food-induced atopic dermatitis is the result of non-classical, IgE-directed hypersensitivity involving resident mast cells, Langerhans cells, CD4+, TH2 lymphocytes and monocytes. A form of gluten sensitivity provokes a characteristic eczematous-like rash and enteropathy (Dermatitis herpetiformis).
Sampson
H A
HA
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
D003874:Dermatitis Herpetiformis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D014581:Urticaria / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology