[Nationwide survey on susceptibilities of clinical isolates to antibacterial agents in 1991].
This study was conducted to investigate susceptibilities of clinical isolates to different antibacterial agents at 123 hospital laboratories throughout Japan from September to December of 1991. In this study, identifications and susceptibility testings were carried out at each hospital laboratory. The susceptibility testing were performed using the disk dilution method recommended by NCCLS. Staphylococcus aureus and CNS showed high or moderate resistance rates to methicillin (DMPPC). Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Proteus mirabilis were highly susceptible to many agents including beta-lactam antibiotics. Though Enterococcus faecalis was highly susceptible to ampicillin (ABPC), piperacillin (PIPC), imipenem (IPM), sulfamethoxazole-trimethoprim (ST) compounds, Enterococcus faecium was resistant to almost all antibacterial agents but to ST compounds. High susceptibility rates were observed for strains of Enterobacter cloacae to IPM, gentamicin (GM) and ofloxacin (OFLX) and for strains of Proteus vulgaris to latamoxef (LMOX), IPM, aztreonam (AZT), GM and OFLX. Serratia marcescens and Bacteroides fragilis group were highly susceptible only to IPM. Pseudomonas aeruginosa were sensitive to ceftazidime (CAZ), IPM, amikacin (AMK) and tobramycin (TOB). Pseudomonas cepacia was relatively susceptible only to CAZ. IPM showed strong antibacterial activity to many species except for S. aureus and CNS.
Tabe
Y
Y
Department of Clinical Pathology, Juntendo University, School of Medicine.
Igari
J
J
D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*
D015378:Imipenem