title: [The effect of sandimmun on the activity of mixed-function mono-oxidases in the liver microsomes].
abstract: The effects of the immunodepressant--the drug sandimmune--on hepatic microsomal monooxygenase activities were studied. The agent was found to produce some inhibiting activity against hepatic microsomal 7-ethoxycoumarine deethylase in male Wistar rats in vitro and in vivo experiments. When given in a dose of 50 mg/kg, sandimmune produced no statistically significant effect on the duration of hexanal-induced sleep in mice. The findings suggest that the agent has slight effects on the tested activities.
authors.forename: E I
authors.initials: EI
authors.lastname: Astashkin
authors.forename: A Z
authors.initials: AZ
authors.lastname: Prikhod'ko
mesh_terms: D015660:7-Alkoxycoumarin O-Dealkylase / Q000187:drug effects; D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects
chemical_list: D016572:Cyclosporine; D006591:Hexobarbital; D006899:Mixed Function Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase
vernacular_title: Vliianie sandimmuna na aktivnost' monooksigenaz so smeshannoĭ funktsieĭ mikrosom pecheni.