title: [Differences in the behavior of organic lesions, immunologic and metabolic parameters in 2 inbred strains of rats].
abstract: Two inbred rat strains were obtained by selective breeding and inbreeding: IR (isoprenaline resistant) and IS (isoprenaline sensitive). In addition to known differences between the two strains (1) other differences were found. As compared to IS strain, IR rats were more aggressive and showed more comfort behaviour in open field test. IR rats developed larger stress-induced gastric lesions but smaller heart lesions. They had larger spleen and thymus and more severe arthritis after Freund adjuvans administration. The two strains might be useful in studying the effects of drugs on various pathological processes. Their hybrids are being used to study interrelations between different genetic factors.
authors.affiliation: Farmakologický ústav 1. LF UK, Praha.
authors.forename: M
authors.initials: M
authors.lastname: Mráz
authors.forename: P
authors.initials: P
authors.lastname: Donát
authors.forename: M
authors.initials: M
authors.lastname: Starec
authors.forename: Z
authors.initials: Z
authors.lastname: Zídek
authors.forename: H
authors.initials: H
authors.lastname: Rasková
authors.forename: S
authors.initials: S
authors.lastname: Hynie
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology / Q000378:metabolism
chemical_list: D007545:Isoproterenol
vernacular_title: Rozdíly chování orgánových lézí, imunologických a metabolických parametrů u dvou inbredních kmenů potkanů.