Bone morphogenetic proteins (BMPs): therapeutic potential in healing bony defects.
The bone morphogenetic proteins (BMPs) belong to a family of proteins that also includes the transforming growth factors beta (TGF-beta) and the inhibins. The BMPs can induce new bone formation in ectopic sites and therefore have enormous potential in bone repair. Studies of fracture-repair models involving BMP-2 suggest that this factor will be useful in healing bony defects in humans. Basic research on the BMPs predict a variety of activities on morphogenesis in systems other than cartilage and bone.
Wang
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EA
Genetics Institute, Cambridge, MA 02140.
D000818:Animals; D001709:Biotechnology; D019485:Bone Morphogenetic Proteins; D004195:Disease Models, Animal; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D006133:Growth Substances / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D010024:Osteoporosis / Q000188:drug therapy; D011506:Proteins / Q000494:pharmacology* / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D011506:Proteins