title: Calcium supplementation in mild preeclampsia remote from term: a randomized double-blind clinical trial.
abstract: OBJECTIVE
  To determine whether calcium supplementation prevents progression to severe disease in preterm nulliparous women with mild preeclampsia.
  
  
  METHODS
  Seventy-five women hospitalized at 24-36 weeks' gestation because of mild preeclampsia were randomized to receive either 2 g/day of elemental calcium (36 women) or placebo (39). Both groups had similar demographic characteristics, initial blood pressure measurements, and amount of proteinuria. Diagnostic criteria and clinical management for severe preeclampsia were applied consistently.
  
  
  RESULTS
  Eighteen of 36 calcium-treated subjects (50%, 95% confidence interval [CI] 33-67) developed severe preeclampsia, compared with 19 of 39 (48.7%, 95% CI 32-65) in the placebo group (relative risk 1.03, 95% CI 0.64-1.03; P = 1.00). Blood pressure values, gestational age at delivery, newborn weights, incidence of low Apgar scores, and umbilical arterial blood gases were similar for the two groups.
  
  
  CONCLUSIONS
  Calcium supplementation does not prevent severe preeclampsia in preterm patients with mild disease.
authors.affiliation: Department of Obstetrics and Gynecology, University of Florida Health Science Center, Jacksonville, USA.
authors.forename: L
authors.initials: L
authors.lastname: Sanchez-Ramos
authors.forename: C D
authors.initials: CD
authors.lastname: Adair
authors.forename: A M
authors.initials: AM
authors.lastname: Kaunitz
authors.forename: D K
authors.initials: DK
authors.lastname: Briones
authors.forename: G O
authors.initials: GO
authors.lastname: Del Valle
authors.forename: I
authors.initials: I
authors.lastname: Delke
mesh_terms: D002118:Calcium / Q000627:therapeutic use*; D016001:Confidence Intervals; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012720:Severity of Illness Index
chemical_list: D002118:Calcium