The chromatin-associated protein H-NS.
H-NS is a major component of chromatin in enteric bacteria. H-NS plays a structural role in organising the chromosome, and influences DNA rearrangements as well as the expression of many genes. The biochemical and functional characteristics of H-NS are distinct from those of 'typical' DNA-binding proteins and much remains to be learned about the mechanism(s) by which H-NS acts. In this article we review our current understanding of the role of H-NS, and describe possible models by which H-NS might influence DNA structure and gene expression.
Ussery
D W
DW
Imperial Cancer Research Fund Laboratories, University of Oxford, John Radcliffe Hospital, UK.
Hinton
J C
JC
Jordi
B J
BJ
Granum
P E
PE
Seirafi
A
A
Stephen
R J
RJ
Tupper
A E
AE
Berridge
G
G
Sidebotham
J M
JM
Higgins
C F
CF
D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry*; D001426:Bacterial Proteins; D002843:Chromatin / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000737:chemistry*; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation; D010641:Phenotype; D011485:Protein Binding
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; C031908:H-NS protein, bacteria; D046911:Macromolecular Substances