Engineering proteins to facilitate bioprocessing.
Genetic engineering is now being applied to aid the purification of recombinant proteins. The addition of specifically designed tags or the modification of sequences within the target-gene product has enabled the development of novel strategies for downstream processing that can be employed for efficient recovery of both native or modified proteins. This article discusses novel trends in genetic engineering that aid the bioprocessing of recombinant proteins.
Nygren
P A
PA
Department of Biochemistry and Biotechnology, Royal Institute of Technology, Stockholm, Sweden.
Ståhl
S
S
Uhlén
M
M
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D015202:Protein Engineering / Q000639:trends; D017510:Protein Folding; D011994:Recombinant Proteins
D011994:Recombinant Proteins