Reversal of lipopolysaccharide-analog-induced antibody suppression by anti-transforming growth factor beta and indomethacin.
Monophosphoryl lipid A and a synthetic, nontoxic monosaccharide analog of lipid A, termed GLA 60, both strongly suppressed antibody production when administered 1 to 2 days prior to antigen. Evidence is presented that this suppression was mediated by two cytokines, prostaglandin E and transforming growth factor beta, because it was reversed by multiple injections of the cyclooxygenase inhibitor indomethacin and by in vitro addition of antibody to transforming growth factor beta.
Odean
M J
MJ
Department of Medical Microbiology and Immunology, University of Minnesota, Duluth 55812, USA.
Johnson
A G
AG
Mohrman
M
M
Hasegawa
A
A
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008050:Lipid A / Q000031:analogs & derivatives* / Q000633:toxicity; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012756:Sheep; D016212:Transforming Growth Factor beta / Q000502:physiology*
D008050:Lipid A; D016212:Transforming Growth Factor beta; C056260:GLA 60; D015232:Dinoprostone; C048436:monophosphoryl lipid A; D007213:Indomethacin