The effect of L-carnitine, administered through intravenous infusion of glucose, on both glucose and insulin levels in healthy subjects.
The goal of the present study was to evaluate the effect of L-carnitine on plasma glucose and insulin levels. Two parallel studies were set-up, of 40 and 20 healthy volunteers, respectively. Each group received 500 cc of 10% glucose or 5% glucose, to which were randomly added 4 g or 2 g of L-carnitine and administered a week apart. Results showed that L-carnitine was able to reduce the increase in glucose plasma levels induced by infusion of the glucose solution. This finding was not dependent on an insulin-dependent mechanism.
Negro
P
P
Polyclinic Umberto I, University La Sapienza, Rome, Italy.
Gossetti
F
F
La Pinta
M
M
Mariani
P
P
Carboni
M
M
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002331:Carnitine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood*; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose; D002331:Carnitine