title: Comparison of the solution structures of microcystin-LR and motuporin.
abstract: A comparison of the structures of two cyanobacterial toxins yields insights into how they may inhibit protein phosphatase-1 and -2A and why microcystins but not motuporin may covalently modify their protein phosphatase targets.
authors.forename: J R
authors.initials: JR
authors.lastname: Bagu
authors.forename: F D
authors.initials: FD
authors.lastname: Sönnichsen
authors.forename: D
authors.initials: D
authors.lastname: Williams
authors.forename: R J
authors.initials: RJ
authors.lastname: Andersen
authors.forename: B D
authors.initials: BD
authors.lastname: Sykes
authors.forename: C F
authors.initials: CF
authors.lastname: Holmes
mesh_terms: D000595:Amino Acid Sequence; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins; D052998:Microcystins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D011485:Protein Binding; D054645:Protein Phosphatase 1; D017434:Protein Structure, Tertiary; D012996:Solutions
chemical_list: D008387:Marine Toxins; D052998:Microcystins; D010456:Peptides, Cyclic; D012996:Solutions; C093605:motuporin; C063998:nodularin; C093607:microcystin LL; C049865:cyanoginosin-LA; D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1; C057862:cyanoginosin LR