[A study of ceftriaxone concentration in serum and tissue of patients with chronic sinusitis].
After an intravenous drip infusion of 1 g or 2 g of ceftriaxone (CTRX), its concentrations in serum and tissue were determined using the bioassay for 18 surgical patients with chronic paranasal sinusitis. 1. The serum levels observed at 75-105, 135-165, 195-225 minutes after an intravenous drip infusion of 1 g, averaged 98 +/- 38, 92 +/- 13 and 73 +/- 13 micrograms/ml, respectively. 2. The tissue levels at 75-105, 135-165, 195-225 minutes after an intravenous drip infusion of 1 g, averaged 27 +/- 13, 27 +/- 7 and 25 +/- 9 micrograms/g. 3. CTRX appears to be a useful drug for the treatment of chronic paranasal sinusitis.
Nakagawa
C
C
Department of Otolaryngology, Yokohama Sakae Kyosai Hospital, Japan.
Kouno
H
H
Tsukuda
M
M
Sawaki
S
S
D000328:Adult; D000368:Aged; D002443:Ceftriaxone / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012852:Sinusitis / Q000188:drug therapy* / Q000378:metabolism*
D002443:Ceftriaxone