title: Time series prediction of plasma hormone concentration. Evidence for differences in predictability of parathyroid hormone secretion between osteoporotic patients and normal controls.
abstract: Recent evidence links osteoporosis, a disease of bone remodeling, to changes in the dynamics of parathyroid hormone secretion. We use nonlinear and linear time series prediction to characterize the secretory dynamics of parathyroid hormone in both healthy human subjects and patients with osteoporosis. Osteoporotic patients appear to lack the periods of high predictability found in normal humans. Our results may provide an explanation for why an intermittent administration of parathyroid hormone is effective in restoring bone mass in osteoporotic patients.
authors.affiliation: Howard Hughes Medical Institute, Salk Institute, San Diego, California 92186-5800, USA.
authors.forename: K
authors.initials: K
authors.lastname: Prank
authors.forename: S J
authors.initials: SJ
authors.lastname: Nowlan
authors.forename: H M
authors.initials: HM
authors.lastname: Harms
authors.forename: M
authors.initials: M
authors.lastname: Kloppstech
authors.forename: G
authors.initials: G
authors.lastname: Brabant
authors.forename: R D
authors.initials: RD
authors.lastname: Hesch
authors.forename: T J
authors.initials: TJ
authors.lastname: Sejnowski
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D016571:Neural Networks, Computer; D010024:Osteoporosis / Q000097:blood / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D010507:Periodicity; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone