Fibroblasts as efficient antigen-presenting cells in lymphoid organs.
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
Kündig
T M
TM
Institute of Experimental Immunology, University of Zürich, Switzerland.
Bachmann
M F
MF
DiPaolo
C
C
Simard
J J
JJ
Battegay
M
M
Lother
H
H
Gessner
A
A
Kühlcke
K
K
Ohashi
P S
PS
Hengartner
H
H
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005347:Fibroblasts / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D007739:L Cells; D008216:Lymphocytic Choriomeningitis / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014162:Transfection; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000276:immunology*
D006023:Glycoproteins; D015395:Histocompatibility Antigens Class I; D014764:Viral Proteins