title: Old phage, new insights: two recently recognized mechanisms of transcriptional regulation in bacteriophage T4 development.
abstract: The regulation of bacteriophage T4 middle and late gene expression involves previously unrecognized mechanisms. Middle transcription requires a DNA-binding transcriptional activator and a sigma 70-binding co-activator. The coupling of late transcription to DNA replication is effected by a DNA-tracking protein that is loaded onto DNA by an assembly factor at enhancer-like entry sites. Late transcription also requires an RNA polymerase core-binding co-activator. The co-activators of T4 middle and late transcription share the property of depressing unactivated, basal transcription.
authors.affiliation: Department of Biological Sciences, State University of New York, Buffalo 14260-1300, USA.
authors.forename: E N
authors.initials: EN
authors.lastname: Brody
authors.forename: G A
authors.initials: GA
authors.lastname: Kassavetis
authors.forename: M
authors.initials: M
authors.lastname: Ouhammouch
authors.forename: G M
authors.initials: GM
authors.lastname: Sanders
authors.forename: R L
authors.initials: RL
authors.lastname: Tinker
authors.forename: E P
authors.initials: EP
authors.lastname: Geiduschek
mesh_terms: D017122:Bacteriophage T4 / Q000235:genetics* / Q000502:physiology; D001483:Base Sequence; D004261:DNA Replication; D004279:DNA, Viral / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
chemical_list: D004279:DNA, Viral