title: Mechanisms in adverse reactions to food. The eye.
abstract: Direct action of triggers on the target organ may cause vasodilation, exudation, hypersecretion and nerve endings stimulation without participation of mast cells and basophils. Non IgE-mediated release of mediators from mast cells and basophils may explain how triggers other than allergens can induce pseudo-allergic reactions. IgE-mediated triggering of mast cells and basophils is not confined - in the eye too - to an immediate reaction, but represents the starting point for a progression to a late-phase reaction with the participation of a network of several cells and mediators. Inflammatory changes associated with late-phase reaction in the eye represent the pathophysiological basis for a non-specific hyperreactivity to various triggers.
authors.affiliation: Chair of Clinical Immunology and Allergy, Second University of Naples, Instituto di I Clinica Medica, Policlinico Umberto, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bonini
authors.forename: S
authors.initials: S
authors.lastname: Bonini
mesh_terms: D003233:Conjunctivitis, Allergic / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005123:Eye / Q000503:physiopathology; D005512:Food Hypersensitivity / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism
chemical_list: D007073:Immunoglobulin E