[Fructose-2,6-bisphosphate system and experimental states].
The molecular mechanisms of the inhibitory action of fructose- 2,6-bisphosphate (F-2,6-P2) on fructose-1,6-biphosphatase (FB-Pase-1), the key enzyme of gluconeogenesis, and the those of the activating action of F-2,6-P2 on phosphofructo-1-kinase (PFK-1), the key enzyme of glycolysis, NMR spectroscopy first provided direct evidence for the fact that F-2,6-P2 was involved in the regulation of the sedoheptulose cycle of a nonoxidative stage of the pentosephosphate pathway. Procedures were developed in measuring the levels of F-2,6-P2 in the cell of experimental animal tissues and human blood lymphocytes. Naturally different emergencies substantially affected the F-2,6-P2 system by triggering these or those mechanisms controlling the activity of enzymes of this system. Vanadium-containing compounds were demonstrated to have a positive action on carbohydrate metabolism in diabetic (streptozotocin-induced) rat hepatocytes.
Korovkin
B F
BF
Beliaeva
N F
NF
Viktorova
L N
LN
Golubev
M A
MA
Gorodetskiĭ
V K
VK
Markova
M S
MS
Saiapin
A V
AV
Stvolinskaia
N S
NS
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000378:metabolism; D050260:Carbohydrate Metabolism; D015687:Cell Hypoxia; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004630:Emergencies; D005635:Fructosediphosphates / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D005943:Gluconeogenesis; D006019:Glycolysis; D006801:Humans; D008099:Liver / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010427:Pentose Phosphate Pathway; D025481:Phosphofructokinase-2; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats
D000889:Anti-Arrhythmia Agents; D005635:Fructosediphosphates; C027652:fructose 2,6-diphosphate; D025481:Phosphofructokinase-2; D010744:Phosphoric Monoester Hydrolases
Sistema fruktozo-2,6-bisfosfata i éksperimental'nye sostoianiia.