title: Serum markers of systemic disease processes in osteoarthritis.
abstract: Serum levels of several molecules originating from joints and cartilages have been shown to rise during the preradiological stages of osteoarthritis (OA). Using a dog model of posttraumatic OA, we have shown that serum levels of markers of aggrecan degradation (antigenic keratan sulfate) and synovial proliferation/metabolism (hyaluronan) rise within 1-2 weeks after the injury and remain elevated for at least 13 weeks. These changes, which precede the development of OA lesions, are consistent with the view that traumatic injury to a single synovial joint gives rise to a state of hypermetabolism that is local at first but becomes systemic with time.
authors.affiliation: Department of Biochemistry, Rush Medical College, Chicago, IL 60612-3864, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Thonar
authors.forename: K
authors.initials: K
authors.lastname: Masuda
authors.forename: M E
authors.initials: ME
authors.lastname: Lenz
authors.forename: H J
authors.initials: HJ
authors.lastname: Hauselmann
authors.forename: K E
authors.initials: KE
authors.lastname: Kuettner
authors.forename: D H
authors.initials: DH
authors.lastname: Manicourt
mesh_terms: D053674:Aggrecans; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D004195:Disease Models, Animal; D004285:Dogs; D016326:Extracellular Matrix Proteins; D006820:Hyaluronic Acid / Q000097:blood / Q000378:metabolism*; D007596:Joints / Q000293:injuries; D037181:Lectins, C-Type; D010003:Osteoarthritis / Q000378:metabolism* / Q000503:physiopathology; D011509:Proteoglycans / Q000097:blood / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D053674:Aggrecans; D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D037181:Lectins, C-Type; D011509:Proteoglycans; D006820:Hyaluronic Acid