title: Risk factors and p53 nuclear overexpression in early stage intestinal-type adenocarcinoma of the stomach.
abstract: In order to investigate the relationship between altered patterns of p53 expression and risk factors for stomach cancer, we have analyzed a group of 35 patients with early stage intestinal-type adenocarcinoma of the stomach. We assessed p53 nuclear overexpression by immunohistochemistry, using monoclonal antibody PAb 1801, and identified 15 out of 35 patients (43%) displaying nuclear overexpression of p53 protein. Significantly elevated odds ratios (O.R.) were observed for greater body mass index (highest quartile versus lowest quartile: O.R. = 7.9; 95% confidence interval (CI): 1.1 to 56.1) and younger age (< 60 vs. > or = 70 years: O.R. = 10; 95% CI, 1.43 to 50). The odds ratio for p53 overexpression in cigarette smokers was 2.8 (95% CI: 0.7 to 11.6) but not statistically significant. These data indicate that p53 mutations may be involved in the early stages of gastric carcinogenesis, especially in the development of intestinal-type adenocarcinoma.
authors.affiliation: Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Z F
authors.initials: ZF
authors.lastname: Zhang
authors.forename: M S
authors.initials: MS
authors.lastname: Karpeh
authors.forename: G Y
authors.initials: GY
authors.lastname: Lauwers
authors.forename: A M
authors.initials: AM
authors.lastname: Marrero
authors.forename: D
authors.initials: D
authors.lastname: Pollack
authors.forename: C
authors.initials: C
authors.lastname: Cordon-Cardo
authors.forename: C
authors.initials: C
authors.lastname: Begg
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000276:immunology*; D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology / Q000276:immunology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D016159:Tumor Suppressor Protein p53