title: Magnetic resonance angiography in 140 neuropediatric patients.
abstract: Three-dimensional magnetic resonance angiography (MRA) is a noninvasive technique that images the intracranial arterial vasculature without contrast agents. The suitability of MRA was evaluated for routine use and all children were prospectively studied with conventional MR imaging and time off flight MRA (FISP3D). All MR studies were performed on a 1.5 T-MRA system using a circularly polarized head coil. The study comprised 140 children, ages 3 weeks to 18 years, with different neuropediatric diseases. Major cervical and intracranial arteries were visualized in all age groups. Smaller branches of the supratentorial arteries were identified inconstantly and the number of arteries visualized increased up to the age of 6 years. Sixty-seven children (47%) had normal intracranial vasculature. MRA demonstrated anatomic variations in 21 patients (15%). Twenty-two of 32 children with congenital malformations demonstrated abnormalities of the intracranial vasculature. The diagnostic value of MRA was confirmed in 11 of 12 patients after neonatal stroke and in 3 of 10 children after stroke at older ages. Seven of 18 children with acute hemorrhage demonstrated arteriovenous malformations or an aneurysm on MRA. The correlation with digital subtraction angiographic findings was established in 13 patients. In 9 of 13 children with brain tumor, MRA proved to be diagnostically valuable. MRA proved to be of particular value in the evaluation of the carotid artery following extracorporeal membrane oxygenation therapy. MRA can be used in children of all age groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Koelfen
authors.forename: U
authors.initials: U
authors.lastname: Wentz
authors.forename: M
authors.initials: M
authors.lastname: Freund
authors.forename: C
authors.initials: C
authors.lastname: Schultze
mesh_terms: D000293:Adolescent; D017542:Aneurysm, Ruptured / Q000175:diagnosis*; D001921:Brain / Q000098:blood supply; D001932:Brain Neoplasms / Q000175:diagnosis*; D002543:Cerebral Hemorrhage / Q000175:diagnosis*; D002561:Cerebrovascular Disorders / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis*; D018810:Magnetic Resonance Angiography; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis; D011446:Prospective Studies; D012016:Reference Values