title: The growing threat of antibiotic-resistant Streptococcus pneumoniae.
abstract: Resistance to penicillin has spread worldwide during the past 25 years. Strains resistant to alternative antibiotics have also emerged. Strains resistant to multiple antibiotics increasingly are isolated worldwide. Recently, isolates of penicillin-resistant S. pneumoniae resistant to cefotaxime and ceftriaxone have caused meningitis. As a result, recommendations for the empiric therapy of pneumococcal infections, especially meningitis, are changing.
authors.affiliation: Department of Medicine, Brown University School of Medicine, Providence, Rhode Island, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Lonks
authors.forename: A A
authors.initials: AA
authors.lastname: Medeiros
mesh_terms: D001428:Bacterial Vaccines / Q000627:therapeutic use; D002439:Cefotaxime / Q000378:metabolism / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004917:Erythromycin / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000378:metabolism / Q000627:therapeutic use; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D022242:Pneumococcal Vaccines; D012307:Risk Factors; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D001428:Bacterial Vaccines; D004269:DNA, Bacterial; D010406:Penicillins; D022242:Pneumococcal Vaccines; D004917:Erythromycin; D002439:Cefotaxime