Carboplatin and etoposide in previously treated colorectal cancer patients.
OBJECTIVE
Salvage treatment of advanced colorectal cancer patients has not been well defined as yet, and new potentially active drugs or combinations should be evaluated for these situations.


METHODS
From February 1993 to September 1993, the combination of carboplatin (CBDCA) and etoposide (VP-16), both as 100 mg/m2 for three consecutive days, was administered to 17 colorectal cancer patients who had been previously subjected to FA-FU combination chemotherapy. The CBDCA + VP-16 treatment was repeated every 3 weeks. A total of 58 cycles was administered, and 16 patients were evaluable for response.


RESULTS
There was no objective response, but 2 stable diseases and 14 progressive diseases were observed. Toxicity was mild, with no WHO 3-4 grade toxicity.


CONCLUSIONS
This combination chemotherapy was judged ineffective for pretreated colorectal cancer patients.
Colucci
G
G
Division of Medicine, Oncology Institute, Bari, Italy.
Maiello
E
E
Giuliani
F
F
Cifarelli
R A
RA
Giotta
F
F
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016879:Salvage Therapy
D005047:Etoposide; D016190:Carboplatin