Effects of pyridoxalated hemoglobin polyoxyethylene conjugate and other hemoglobin-related substances on arterial blood pressure in anesthetized and conscious rats.
The effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) and other hemoglobin-related substances on arterial blood pressure (ABP) and heart rate (HR) were examined. Infusion of PHP and other hemoglobin-related substances elevated ABP and increased HR. The degree of the increase in ABP and HR did not differ among the groups. There were species' differences in responses to PHP. Pretreatment with various blockers did not abolish the elevation of ABP. The pretreatment of NG-monomethyl-L-arginine dose-dependently reduced the elevation of ABP but did not completely abolish it. PHP also elevated ABP in conscious rats. The magnitude of the ABP elevation was significantly smaller than in the anesthetized rats. Results indicate that inhibition of nitric oxide (NO) might be responsible in part for the elevation of ABP, and the degree of the elevation would be dependent on the degree of contribution of NO to the regulation of ABP.
Kida
Y
Y
Life Science Laboratories, Central Research Laboratories Ajinomoto, Co., Inc., Yokohama, Japan.
Maeda
M
M
Iwata
S
S
Iwashita
Y
Y
Goto
K
K
Nishi
K
K
D018674:Adrenergic Antagonists / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006454:Hemoglobins / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D019323:omega-N-Methylarginine
D018674:Adrenergic Antagonists; D016861:Cyclooxygenase Inhibitors; D006454:Hemoglobins; C016484:hemoglobin, stroma free; C050907:pyridoxalated-hemoglobin-polyethylene glycol conjugate; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D011092:Polyethylene Glycols; D001120:Arginine