title: 15-hydroperoxydehydroabietic acid--a contact allergen in colophony from pinus species.
abstract: A new hydroperoxide, 15-hydroperoxydehydroabietic acid (15-HPDA), with contact allergenic properties has been detected in rosin obtained from Pinus species. Detection was facilitated using a synthetic preparation of 15-HPDA for reference purposes. The synthesis and the detection (HPLC and GC) of 15-HPDA in rosin are described. The allergenic activity of 15-HPDA was studied in an experimental sensitization test on guinea-pigs.
authors.affiliation: Department of Occupational Dermatology, National Institute of Occupational Health, Solna, Stockholm, Sweden.
authors.forename: L P
authors.initials: LP
authors.lastname: Shao
authors.forename: E
authors.initials: E
authors.lastname: Gäfvert
authors.forename: U
authors.initials: U
authors.lastname: Nilsson
authors.forename: A T
authors.initials: AT
authors.lastname: Karlberg
authors.forename: J L
authors.initials: JL
authors.lastname: Nilsson
mesh_terms: D045784:Abietanes; D000485:Allergens / Q000032:analysis*; D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000032:analysis*; D006168:Guinea Pigs; D013058:Mass Spectrometry / Q000379:methods; D010616:Phenanthrenes / Q000032:analysis*; D014197:Trees / Q000737:chemistry*
chemical_list: C093859:15-hydroperoxydehydroabietic acid; D045784:Abietanes; D000485:Allergens; D004224:Diterpenes; D010616:Phenanthrenes; C093860:methyl 15-hydroperoxydihydroabietate