Potentiation and depotentiation of DNQX-sensitive fast excitatory synaptic transmission in telencephalone of the quail chick.
Whole-cell perforated-patch recording in slices revealed synaptic organization of the intermediate medial hyperstriatum ventrale, a telencephalic region intimately involved in the early learning processes in chicks. Local electrical stimuli elicited excitatory post-synaptic current (EPSC) mediated by monosynaptic activation of glutamate receptors of the non-N-methyl-D-aspartate type, which was followed by a late GABAA-ergic inhibition. The initial EPSC was potentiated at least for 60 min, when a tetanic stimulation (5 Hz x 60 s) was combined with post-synaptic depolarization at or above -30 mV. In some of these neurons, the potentiated responses underwent a subsequent depression when a second tetanus was accompanied by hyperpolarization at -80 mV or below.
Matsushima
T
T
Life Science Institute, Sophia University, Tokyo, Japan.
Aoki
K
K
D000818:Animals; D001362:Avoidance Learning; D002642:Chick Embryo; D004558:Electric Stimulation; D005071:Evoked Potentials; D017774:Long-Term Potentiation; D018408:Patch-Clamp Techniques; D011784:Quail; D011810:Quinoxalines / Q000494:pharmacology; D009435:Synaptic Transmission / Q000502:physiology*; D013687:Telencephalon / Q000502:physiology*
D011810:Quinoxalines; C056723:FG 9041