title: Carcinoma ex pleomorphic adenoma of the soft palate.
abstract: A case of carcinoma ex pleomorphic adenoma arising in the soft palate is reported. The tumour presented had enlarged gradually over 10 years and finally occupied the oral cavity. The patient was admitted to our hospital due to disturbance of her speech and swallowing, and a sudden haemorrhage from the tumour. The initial pathological diagnosis by open biopsy was benign pleomorphic adenoma. After total resection, histological examination revealed that the tumour was composed partly of benign pleomorphic adenoma and partly of an adenocarcinomatous component. The carcinoma cells with prominent nucleoli were spheroid or polygonal in shape, and frequently formed ductal structures with areas of necrosis. Mitoses were also found. These findings showed that this tumour was a secondary carcinoma which had developed in a preexisting pleomorphic adenoma.
authors.affiliation: Department of Otolaryngology, Tokyo Women's Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshihara
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Ishii
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010160:Palate, Soft / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor