title: Disseminated intravascular coagulation in transfusion-associated graft-versus-host disease. Report of two cases.
abstract: In two cases of transfusion-associated graft-versus-host disease (TA-GVHD), severe bleeding tendencies were observed besides the characteristic features of the disease. An elevation of fibrin degradation products (FDP), D-dimer, thrombin-antithrombin III complex (TAT) and plasmin-alpha 2 plasmin inhibitor complex (PIC), was revealed. These findings were compatible with disseminated intravascular coagulation (DIC). To our knowledge, the association of TA-GVHD and DIC has not been described, and it is our speculation that allogeneic immune reactions may play some pathogenic role in developing DIC in TA-GVHD. The DIC may be responsible for the rapid progression of multiple organ failure (MOF) in TA-GVHD.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Murakawa
authors.forename: T
authors.initials: T
authors.lastname: Okamura
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Esaki
authors.forename: T
authors.initials: T
authors.lastname: Kamura
authors.forename: T
authors.initials: T
authors.lastname: Shibuya
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
mesh_terms: D000368:Aged; D000933:Antifibrinolytic Agents / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis; D016207:Cytokines / Q000032:analysis; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000473:pathology; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005341:Fibrinolysin / Q000032:analysis; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006680:HLA Antigens / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000032:analysis; D065227:Transfusion Reaction; D000979:alpha-2-Antiplasmin
chemical_list: D000933:Antifibrinolytic Agents; D016207:Cytokines; D005338:Fibrin Fibrinogen Degradation Products; D006680:HLA Antigens; D000979:alpha-2-Antiplasmin; C046193:antithrombin III-protease complex; C037742:plasmin-plasmin inhibitor complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D005341:Fibrinolysin