title: Insulin-stimulated polypeptide chain elongation in the soleus muscle of mice.
abstract: The effect of insulin on polypeptide chain elongation was examined in soleus muscles isolated from 18 hour-fasted mice. Treatment with insulin for 1 hour increased the elongation rate, which was estimated by the half-transit time. This suggests that insulin stimulated protein synthesis by modifying the elongation rate in addition to the initiation rate.
authors.affiliation: Department of Applied Biological Science, Tokyo Noko University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yoshizawa
authors.forename: A
authors.initials: A
authors.lastname: Tonouchi
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Yagasaki
authors.forename: R
authors.initials: R
authors.lastname: Funabiki
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009124:Muscle Proteins / Q000096:biosynthesis*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010452:Peptide Biosynthesis; D010441:Peptide Chain Elongation, Translational / Q000187:drug effects*; D020648:Peptide Elongation Factor 1; D020652:Peptide Elongation Factor 2; D010445:Peptide Elongation Factors / Q000378:metabolism; D010766:Phosphorylation; D012261:Ribonucleoproteins / Q000378:metabolism
chemical_list: D007328:Insulin; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D020648:Peptide Elongation Factor 1; D020652:Peptide Elongation Factor 2; D010445:Peptide Elongation Factors; D012261:Ribonucleoproteins