The antiallergic activities of synthetic acrophylline and acrophyllidine.
The antiallergic activities of synthetic acrophylline [1] and acrophyllidine [2] have been demonstrated. Both compounds 1 and 2 at 30 mumol/kg reduced the plasma leakage in mouse ear in a passive cutaneous anaphylactic (PCA) reaction. In addition, compound 1 suppressed mast cell degranulation in a dose-dependent manner, while compound 2 at 100 microM produced no significant inhibition of the release of preformed inflammatory mediators. These results suggest that the antiallergic effect of compound 1 probably occurs through the suppression of mast cell degranulation, and that of compound 2 by protection of the vasculature against challenge by mediators of inflammation.
Huang
A C
AC
Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan.
Lin
T P
TP
Kuo
S C
SC
Wang
J P
JP
D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D006967:Hypersensitivity / Q000188:drug therapy*; D018836:Inflammation Mediators / Q000378:metabolism; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D011804:Quinolines; D015363:Quinolones; D051381:Rats; D017207:Rats, Sprague-Dawley
D000470:Alkaloids; D018836:Inflammation Mediators; D011804:Quinolines; D015363:Quinolones; C093763:acrophyllidine; C093762:acrophylline