title: Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.
authors.affiliation: Department of Chemistry, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Wetzel
authors.forename: S W
authors.initials: SW
authors.lastname: Miao
authors.forename: C
authors.initials: C
authors.lastname: Forray
authors.forename: L A
authors.initials: LA
authors.lastname: Borden
authors.forename: T A
authors.initials: TA
authors.lastname: Branchek
authors.forename: C
authors.initials: C
authors.lastname: Gluchowski
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000737:chemistry*; D002460:Cell Line; D003001:Cloning, Molecular; D004095:Dihydropyridines / Q000737:chemistry*; D006801:Humans; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D018340:Receptors, Adrenergic, alpha-1; C054074:niguldipine