Apolipoprotein E type epsilon 4 allele frequency is not increased in patients with sporadic inclusion-body myositis.
The apolipoprotein E genotype was determined for 11 patients with sporadic inclusion-body myositis. Seven cases had the genotype epsilon 3/epsilon 3, the other four cases, epsilon 3/epsilon 4. The frequency of the epsilon 4 allele in this group of patients (0.182) was not significantly increased compared with elderly controls (0.147; n = 58), in contrast to Alzheimer's disease in which there was a significant increase (0.328; n = 67). The epsilon 2 allele was not found in any of the 11 sporadic inclusion-body myositis patients and its frequency was decreased in Alzheimer's disease. Despite certain pathological similarities that exist between inclusion body myositis and Alzheimer's disease, their association with particular apolipoprotein E genotypes is distinct.
Harrington
C R
CR
Cambridge Brain Bank Laboratory, Department of Psychiatry, University of Cambridge Clinical School, UK.
Anderson
J R
JR
Chan
K K
KK
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009220:Myositis / Q000175:diagnosis* / Q000235:genetics; D016875:tau Proteins
D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D016875:tau Proteins