title: Intranigral injected iron progressively reduces striatal dopamine metabolism.
abstract: The striatal dopamine metabolism of the rat was followed 1, 3, and 6 weeks after unilateral intranigral iron (III) (50- and 1.5 micrograms) application. For both concentrations a progredient decrease of extraneuronal 3.4-dihydroxyphenylacetic acid (DOPA) levels was observed in the ipsilateral striatum.
authors.affiliation: Department of Neurochemistry, Institute of Physiological Chemistry, Marburg, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Wesemann
authors.forename: S
authors.initials: S
authors.lastname: Blaschke
authors.forename: M
authors.initials: M
authors.lastname: Solbach
authors.forename: C
authors.initials: C
authors.lastname: Grote
authors.forename: H W
authors.initials: HW
authors.lastname: Clement
authors.forename: P
authors.initials: P
authors.lastname: Riederer
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005290:Ferric Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D010300:Parkinson Disease / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000187:drug effects*
chemical_list: D005290:Ferric Compounds; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine