title: Pulmonary intravascular macrophages in the pathogenesis of bovine pulmonary lesions caused by Actinomyces pyogenes.
abstract: Rabbit antisera raised against somatic antigens from two strains of Actinomyces pyogenes reacted specifically in a peroxidase anti-peroxidase technique which was developed for the location of the bacteria in formalin-fixed tissues. The technique was applied on experimental murine and spontaneous bovine lesions caused by A. pyogenes. By electron microscopy and immunohistochemistry it was demonstrated that pulmonary intravascular macrophages play a role in the uptake of A. pyogenes from the blood, and in the production of pyaemic pulmonary lesions.
authors.affiliation: Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University Copenhagen, Frederiksberg C, Denmark.
authors.forename: P S
authors.initials: PS
authors.lastname: Leifsson
authors.forename: A
authors.initials: A
authors.lastname: Basse
authors.forename: H E
authors.initials: HE
authors.lastname: Jensen
authors.forename: B
authors.initials: B
authors.lastname: Bloch
authors.forename: B
authors.initials: B
authors.lastname: Aalbaek
mesh_terms: D000190:Actinomyces / Q000302:isolation & purification / Q000472:pathogenicity*; D000196:Actinomycosis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D005260:Female; D007150:Immunohistochemistry; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008171:Lung Diseases / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D016676:Macrophages, Alveolar / Q000276:immunology*; D051379:Mice; D008854:Microscopy, Electron; D010587:Phagocytosis / Q000276:immunology; D011651:Pulmonary Artery / Q000276:immunology / Q000473:pathology; D013927:Thrombosis / Q000209:etiology
chemical_list: D000942:Antigens, Bacterial