title: Methadone dosing and pregnancy: impact on program compliance.
abstract: A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45. Earlier program entry was associated with decreased opiate and cocaine use and increased compliance with urinalysis requests. The single dose and split-dose groups differed in urine toxicology compliance rates, 23.8 vs 0.5%, as well as percentages of urines positive for cocaine, 15.3 vs 0.3%, only in Trimester III.
authors.affiliation: Department of Medicine, Roger Williams Hospital, Brown University, Providence, Rhode Island 02908, USA.
authors.forename: P B
authors.initials: PB
authors.lastname: DePetrillo
authors.forename: J M
authors.initials: JM
authors.lastname: Rice
mesh_terms: D000553:Ambulatory Care; D003042:Cocaine; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008691:Methadone / Q000008:administration & dosage* / Q000009:adverse effects; D009293:Opioid-Related Disorders / Q000523:psychology / Q000534:rehabilitation*; D010349:Patient Compliance / Q000523:psychology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology / Q000534:rehabilitation*; D015813:Substance Abuse Detection; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*
chemical_list: D003042:Cocaine; D008691:Methadone