Chemical protein sequencing and amino acid analysis.
Chemical protein sequencing remains the cornerstone of protein structural analysis. Recent developments allow an increased rate of sampling and a reduction in background noise. Mass spectrometric detection of chemical sequencing products will, in all likelihood, initiate an era of sequencing of sub-picomole quantities of protein. Significant progress toward routine, automated carboxy-terminal sequencing has been reported recently.
Stolowitz
M L
ML
Center For Molecular Biotechnology, California Institute of Technology, Pasadena 95211.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D001331:Automation; D011145:Polyvinyls; D011506:Proteins / Q000737:chemistry*; D017421:Sequence Analysis; D005465:Fluorocarbon Polymers
D000596:Amino Acids; D011145:Polyvinyls; D011506:Proteins; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers