[The effect of Baji Zibugao on the serum levels of endocrines in thyroidectomized (yang deficiency) rabbits].
In order to study the effect of Baji Zibugao (BJZBG, a medicinal plaster mainly consisting of Radix Morindae Officinalis) on the endocrine functions of hypothyroid rabbits, we determined the serum levels of thyroxine (T4), triiodothyronine (T3), cAMP, cGMP and corticosterone in three groups of rabbits: total thyroidectomized and untreated (group I), total thyroidectomized and treated with BJZBG (group II) and controls (group III). The results showed: (1) The serum level of T4 in group I and II after operation was significantly lower than that before operation (P < 0.005), and the serum level of T3 in group I was also lower than that before operation (P < 0.02), but the change of T3 in group II after operation was not significant (P > 0.05); (2) The serum cAMP level in group I after operation decreased and the cGMP level increased (P < 0.025), but the changes of cAMP and cGMP level in group II after operation were not significant (P > 0.05), (3) The change of serum corticosterone level in group I or II after operation was not remarkable (P > 0.05).
Xu
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Institute of Clinical Pharmacology, Guangzhou College of TCM.
Deng
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Zhang
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Xu
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Lin
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D000818:Animals; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007037:Hypothyroidism / Q000097:blood*; D011817:Rabbits; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D016711:Yang Deficiency / Q000097:blood*
D004365:Drugs, Chinese Herbal; D014284:Triiodothyronine; D000242:Cyclic AMP; D006152:Cyclic GMP; D013974:Thyroxine