Spatio-temporal pattern of ocular clusterin mRNA expression in the rd mouse.
To define the relationship between progressive photoreceptor degeneration and clusterin upregulation, we analysed the spatio-temporal distribution and level of clusterin mRNA in the retinal degeneration (rd) mouse. Expression was increased in the retinal pigment epithelium and inner retina, but not detected in the photoreceptors. These results indicate that increased clusterin mRNA is not causally involved in apoptotic mechanisms of photoreceptor death but may relate to lipid-recycling or cytoprotective functions.
Jomary
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British Retinitis Pigmentosa Society Laboratory, Department of Pharmacology, Rayne Institute, UMDS, Guy's Hospital, London, UK.
Ahir
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A
Agarwal
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N
Neal
M J
MJ
Jones
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SE
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D015152:Blotting, Northern; D051152:Clusterin; D005123:Eye / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics*; D051379:Mice; D018832:Molecular Chaperones; D009419:Nerve Tissue Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D012162:Retinal Degeneration / Q000235:genetics* / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
C495243:Clu protein, mouse; D051152:Clusterin; D006023:Glycoproteins; D018832:Molecular Chaperones; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger