A macrocircular ellagitannin, oenothein B, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase.
Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.
Aoki
K
K
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Maruta
H
H
Uchiumi
F
F
Hatano
T
T
Yoshida
T
T
Tanuma
S
S
D000818:Animals; D015967:Gene Expression Regulation, Viral / Q000187:drug effects*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D006609:High Mobility Group Proteins / Q000378:metabolism; D047348:Hydrolyzable Tannins; D008324:Mammary Tumor Virus, Mouse / Q000187:drug effects* / Q000235:genetics; D051379:Mice; D008809:Mice, Inbred C3H; D012333:RNA, Messenger / Q000235:genetics; D013634:Tannins / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D006609:High Mobility Group Proteins; D047348:Hydrolyzable Tannins; D012333:RNA, Messenger; D013634:Tannins; C080077:oenothein B; D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase