title: Relative bioavailability of a new oral form of cyclosporin A in patients with rheumatoid arthritis.
abstract: The relative bioavailability of cyclosporin A (CsA) from a new microemulsion oral formulation (NEO) and the currently used soft gelatine capsule (SGC) was determined at steady state in 12 patients with rheumatoid arthritis. The AUC(0,12 h) values of cyclosporin A were significantly greater after NEO than SGC (2873 +/- 848 ng ml-1 h (mean +/- s.d.) vs 2355 +/- 1128 ng ml-1 h; P = 0.02, 95% CI (confidence interval of the difference: 81 to 955 ng ml-1 h). Cmax values were significantly higher after NEO than after SGC (811 +/- 244 ng ml-1 vs 495 +/- 291 ng ml-1, P < 0.0001, 95% CI of the difference: 209 to 422 ng ml-1).
authors.affiliation: Department of Rheumatology, University Hospital, Leiden, The Netherlands.
authors.forename: B E
authors.initials: BE
authors.lastname: van den Borne
authors.forename: R B
authors.initials: RB
authors.lastname: Landewé
authors.forename: H S
authors.initials: HS
authors.lastname: Goei The
authors.forename: H
authors.initials: H
authors.lastname: Mattie
authors.forename: F C
authors.initials: FC
authors.lastname: Breedveld
authors.forename: B A
authors.initials: BA
authors.lastname: Dijkmans
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D001682:Biological Availability; D002214:Capsules; D016572:Cyclosporine / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004655:Emulsions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002214:Capsules; D004655:Emulsions; D016572:Cyclosporine