title: [Vitamin D and pubertal maturation. Value and tolerance of vitamin D supplementation during the winter season].
abstract: BACKGROUND
  In France, several cases of vitamin D-deficiency rickets among adolescents have been reported, but no prophylaxis measure has been systematically recommended at this age. The aim of this study was to measure 25-hydroxyvitamin D (25-(OH)D) levels and to search for biological signs of vitamin D deficiency during adolescence. Moreover, the effects of a unique oral dose of 100,000 IU of vitamin D3, given during the winter, were analysed.
  
  
  METHODS
  Circulating levels of 25-(OH)D, 1,25-dihydroxyvitamin D, intact parathyroid hormone (iPTH), alkaline phosphatase activities, calcium and phosphate were measured in 53 adolescents aged 10-17 years (81% of metropolitan origin), seen during the winter. The effect of a single oral dose of 100,000 IU of vitamin D3 or of placebo was studied in 15 of these subjects.
  
  
  RESULTS
  24.5% of the adolescents had low 25-(OH)D concentrations (< 6 ng/ml), this frequency being even more elevated (38%) at the end of pubertal maturation (stages 4 and 5). An increase in iPTH concentrations was found in subjects with lowest 25-(OH)D levels (< 3 ng/ml). An oral dose of 100,000 IU of vitamin D3 resulted in a significant increase in the 25-(OH)D levels; yet, these levels remained within the normal range during the 1-2 month follow-up of the nine treated subjects. This dosage made it possible to correct the low calcium concentrations (2.20-2.24 mmol/l) found before treatment in three adolescents.
  
  
  CONCLUSIONS
  The high frequency of low vitamin D status observed during puberty and its normalization after a 100,000 IU vitamin D3 supplementation show the interest and safety of this intermittent 100,000 IU vitamin D3 supplementation to adolescents during the winter season.
authors.affiliation: CNRS URA 583, université Paris-V, hôpital Saint-Vincent-de-Paul, France.
authors.forename: F
authors.initials: F
authors.lastname: Zeghoud
authors.forename: R
authors.initials: R
authors.lastname: Delaveyne
authors.forename: P
authors.initials: P
authors.lastname: Rehel
authors.forename: J
authors.initials: J
authors.lastname: Chalas
authors.forename: M
authors.initials: M
authors.lastname: Garabédian
authors.forename: M
authors.initials: M
authors.lastname: Odièvre
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000378:metabolism; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood; D002648:Child; D005260:Female; D005527:Food, Fortified; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011627:Puberty / Q000097:blood*; D012621:Seasons; D012741:Sexual Maturation; D014807:Vitamin D / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D000469:Alkaline Phosphatase; D002117:Calcitriol; D002118:Calcium
vernacular_title: Vitamine D et maturation pubertaire. Intérêt et tolérance d'une supplémentation vitaminique D en période hivernale.