title: Proton magnetic resonance spectroscopy (1H-MRS) for the evaluation of treatment of brain tumours.
abstract: We investigated metabolic changes in brain tumours following treatment, using proton magnetic resonance spectroscopy. In meningiomas, effective therapeutic embolisation led to an acute increase in lactate. In radiosensitive tumours such as malignant lymphoma, a decrease in lactate and in increase in N-acetyl-aspartate occurred after radiotherapy, which preceded changes observed on magnetic resonance imaging. On the other hand, no significant changes in spectral patterns were observed in malignant gliomas resistant to therapy. Tissue characterisation of brain tumours by spectral patterns on proton magnetic resonance spectroscopy remains controversial. However, we have shown it to be sensitive to metabolic changes following treatment, which may reflect the efficacy of the therapy.
authors.affiliation: Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Houkin
authors.forename: K
authors.initials: K
authors.lastname: Kamada
authors.forename: Y
authors.initials: Y
authors.lastname: Sawamura
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Kashiwaba
mesh_terms: D001254:Astrocytoma / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism* / Q000628:therapy; D004621:Embolization, Therapeutic; D006801:Humans; D008223:Lymphoma / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008577:Meningeal Neoplasms / Q000378:metabolism; D008579:Meningioma / Q000378:metabolism; D011522:Protons; D012680:Sensitivity and Specificity
chemical_list: D011522:Protons