[The analgesic action of new enkephalin analogs].
The enkephalin analogue peptide IKB-901 containing epsilon-ACA and cysteine with the modified S-end shows an analgetic activity in rats (1 micron, intrathecally and 5 mg/kg intravenously) and in cats (0.35 and 0.7 mg/kg intravenously). Naloxone (0.1 mg/kg) prevents the analgetic effect of peptide. The coadministration of the peptide and the enkephalinase inhibitor D-phenylalanine (0.35 and 10 mg/kg, respectively) enhances analgesia and displays an antihypertensive effect in nociceptive stimulation.
Solov'eva
E V
EV
Kulikov
S V
SV
Khar'kovskiĭ
A O
AO
Bogdanov
E G
EG
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004745:Enkephalins / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D010146:Pain / Q000188:drug therapy; D051381:Rats; D013997:Time Factors
D000700:Analgesics; D004745:Enkephalins
O boleutoliaiushchem deĭstvii novykh analogov énkefalinov.