title: A three dimensional model for the interaction of MSH with the melanocortin-1 receptor.
abstract: A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling using bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into a binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in TM3 of receptor with histidine in cyclic MSH-peptide, H260 in TM6 with glutamic in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.
authors.affiliation: Department of Pharmaceutical Pharmacology, Uppsala University, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Prusis
authors.forename: P A
authors.initials: PA
authors.lastname: Frändberg
authors.forename: R
authors.initials: R
authors.lastname: Muceniece
authors.forename: I
authors.initials: I
authors.lastname: Kalvinsh
authors.forename: J E
authors.initials: JE
authors.lastname: Wikberg
mesh_terms: D000595:Amino Acid Sequence; D003198:Computer Simulation; D008024:Ligands; D009074:Melanocyte-Stimulating Hormones / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011979:Receptors, Pituitary Hormone / Q000378:metabolism / Q000648:ultrastructure*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D008024:Ligands; D010456:Peptides, Cyclic; D011979:Receptors, Pituitary Hormone; C029446:MSH receptor; D009074:Melanocyte-Stimulating Hormones