[Furosemide long-term inhalation therapy in patients with nasal polyposis].
Study aimed principally at applying the data recently gathered with regard to Bronchial Reactivity to rhinology, with special regard to non-atopic or allergic hyperresponsiveness. In the past decade, Ultrasonic Nebulized Distilled Water (U.N.D.W.) was recognized as one of the best test in Bronchial Reactivity. In allergic and non-allergic rhinitis, the Authors tried to use U.N.D.W. to reproduce symptoms of rhinitis. Results show that U.N.D.W. could be included in the Nasal Hyperreactivity test. Secondly, but not less interesting, is the prevention of experimental rhinitis with U.N.D.W. by using Furosemide, a diuretic administered by inhalation. The prevention of Ca++ penetration into nasal cell can block any mediator-activation. Such procedure may be applied in polyposis after surgery in order to prevention recurrence, data show the complete applicability of this pharmacological treatment in children as well.
Ferrara
A
A
Insegnamento di Fisiopatologia Respiratoria, Università degli Studi di Siena.
Stortini
G
G
Bellussi
L
L
Di Girolamo
S
S
Zuccarini
N
N
Passali
D
D
D000280:Administration, Inhalation; D000328:Adult; D002985:Clinical Protocols; D005260:Female; D005665:Furosemide / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects; D009298:Nasal Polyps / Q000188:drug therapy*
D005665:Furosemide
L'impiego long-term di furosemide per via inalatoria nei pazienti con poliposi nasale.