title: Poor renal uptake of Tc-99m DMSA and Tc-99m MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate.
abstract: The authors present a patient with Fanconi syndrome who demonstrated poor renal uptake of Tc-99m DMSA and high urinary concentration of the tracer. Tc-99m DTPA imaging was normal and the creatinine clearance was only minimally decreased. These findings suggest that Tc-99m DMSA may be accumulated in the kidney by glomerular filtration and subsequent tubular reabsorption. A Tc-99m MDP bone scan showed faint renal uptake, as well as diffuse high skeletal uptake, particularly in the spine, demonstrating that the metabolic bone disease associated with Fanconi syndrome can be one of the causes of poor renal visualization on a bone scan.
authors.affiliation: Department of Nuclear Medicine, Seoul National University Hospital, Korea.
authors.forename: S E
authors.initials: SE
authors.lastname: Kim
authors.forename: J T
authors.initials: JT
authors.lastname: Cho
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: J K
authors.initials: JK
authors.lastname: Chung
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: M C
authors.initials: MC
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: C S
authors.initials: CS
authors.lastname: Koh
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging; D005198:Fanconi Syndrome / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000000981:diagnostic imaging; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013669:Technetium Tc 99m Medronate
chemical_list: D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer; D013669:Technetium Tc 99m Medronate