Simple test for the Hardy-Weinberg law for HLA data with no observed double blanks.
Eguchi and Matsuura (1990, Biometrics 46, 415-426) noted that the generalized Stevens test statistic for the Hardy-Weinberg law for human leukocyte antigen (HLA) data yields an excessively large value when no double blanks are observed. In this paper, we investigated this aberrant case. The inflated value of the test statistic is caused mainly by a seriously biased Bernstein's estimator of the recessive. We propose the generalized Stevens test using bias-corrected Bernstein's estimators for HLA data with no observed double blanks. An example illustrates the correction of the test statistic.
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Biostatistics Branch, National Cancer Institute, Rockville, Maryland 20892, USA.
D000017:ABO Blood-Group System / Q000235:genetics; D000483:Alleles; D001699:Biometry / Q000379:methods; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D017056:Medical Laboratory Personnel; D015233:Models, Statistical; D010641:Phenotype
D000017:ABO Blood-Group System; D006680:HLA Antigens; D006684:HLA-DR Antigens