title: Stereotactic external beam irradiation using a linear accelerator: the Washington University experience.
abstract: From February 1989 to December 1993, 139 patients with a variety of brain lesions were treated with stereotactic external beam irradiation using a 6MV linear accelerator. The largest group consisted of patients with recurrent brain metastases (n = 46). Twenty seven patients had malignant gliomas, most of which were recurrent. Several benign conditions were treated, including arteriovenous malformations (n = 27), acoustic neuromas (n = 9), meningiomas (n = 7), and pituitary adenomas (n = 2). Durable responses were seen in the majority of patients with transient, mild, side effects. This experience suggests that stereotactic external beam irradiation is a safe, reliable, and effective method for non-invasive treatment of selected patients with small, localized brain lesions.
authors.affiliation: Radiation Oncology Center, Washington University School of Medicine, Jewish Hospital of St. Louis, Missouri.
authors.forename: J R
authors.initials: JR
authors.lastname: Simpson
authors.forename: K M
authors.initials: KM
authors.lastname: Rich
authors.forename: R E
authors.initials: RE
authors.lastname: Drzymala
authors.forename: T H
authors.initials: TH
authors.lastname: Wasserman
authors.forename: E E
authors.initials: EE
authors.lastname: Klein
authors.forename: M
authors.initials: M
authors.lastname: Michaletz-Lorenz
authors.forename: J
authors.initials: J
authors.lastname: Maurath
authors.forename: E
authors.initials: E
authors.lastname: Filiput
mesh_terms: D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis / Q000532:radiotherapy*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008279:Magnetic Resonance Imaging; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods; D011882:Radiotherapy, High-Energy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014861:Washington