title: Lipogenic activities in rat liver are subjected to circadian rhythms.
abstract: Diurnal variations were investigated in the activities of the key lipogenic enzymes in rat liver under standard experimental conditions. Fatty acid synthetase, acetyl-CoA-carboxylase, and ATP-citrate lyase showed sinusoidal circadian rhythms (statistically sustained), reaching maximum activity at night and minimum during the light period, with a fold increase value of 1.7, 2.2 and 3.2, respectively. Although a non-sinusoidal circadian rhythm was observed in the malic enzyme activity, statistically different time-dependent activity values were detected throughout a day. The observed rhythms run in parallel with that previously reported for glucose-6-phosphate dehydrogenase, suggesting a whole circadian regulation for rat liver lipogenesis.
authors.affiliation: Departamento de Bioquímica y Biología Molecular IV, Universidad Complutense de Madrid, Facultad de Veterinaria, Ciudad Universitaria, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Zardoya
authors.forename: A
authors.initials: A
authors.lastname: Diez
authors.forename: M C
authors.initials: MC
authors.lastname: Serradilla
authors.forename: J A
authors.initials: JA
authors.lastname: Madrid
authors.forename: J M
authors.initials: JM
authors.lastname: Bautista
authors.forename: A
authors.initials: A
authors.lastname: Garrido-Pertierra
mesh_terms: D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D064429:Fatty Acid Synthases / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar / Q000502:physiology*; D013997:Time Factors
chemical_list: D008055:Lipids; D008291:Malate Dehydrogenase; C030574:malate dehydrogenase (decarboxylating); D064429:Fatty Acid Synthases; D001275:ATP Citrate (pro-S)-Lyase; D000103:Acetyl-CoA Carboxylase