title: Early hepatocellular carcinoma that develops within macroregenerative nodules: growth rate depicted at serial MR imaging.
abstract: OBJECTIVE
  To assess by means of magnetic resonance (MR) imaging the growth rate of early hepatocellular carcinoma (HCC) that develops within macroregenerative nodules.
  
  
  METHODS
  Serial MR imaging was performed in five patients with six macroregenerative nodules that demonstrated a "nodule-within-nodule" pattern (small intranodular focus). The diameter and volume increases of the internal foci at different time intervals were estimated. Average doubling time (DT) was then calculated.
  
  
  RESULTS
  The tiny foci within macroregenerative nodules exhibited rapid growth, with average DTs of 29 weeks for diameter and 9.5 weeks for volume. HCC was proved histopathologically in all five patients.
  
  
  CONCLUSIONS
  HCC, which manifests initially as a small focus within a macroregenerative nodule, has the potential for rapid growth. This growth rate should be considered when plans are formulated for follow-up and/or treatment.
authors.affiliation: Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Sadek
authors.forename: D G
authors.initials: DG
authors.lastname: Mitchell
authors.forename: E S
authors.initials: ES
authors.lastname: Siegelman
authors.forename: E K
authors.initials: EK
authors.lastname: Outwater
authors.forename: T
authors.initials: T
authors.lastname: Matteuccí
authors.forename: H W
authors.initials: HW
authors.lastname: Hann
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies