title: Comparative study of the effect of sodium fluoride and sodium monofluorophosphate on glucose homeostasis in the rat.
abstract: The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared. The oral administration of a single dose of 40 mumol/100 g b.w. of either compound produced similar increases in plasma glucose (up to 1.8 g/l) and diffusible fluoride (up to 130 mumol/l). In long-term experiments (three months of duration), treatment with NaF (a 5 mmol/l solution as the water supply) produced, in the first month of experiment, abnormal glucose tolerance tests and increased plasma diffusible fluoride levels (range: 2-12 mumol/l). Treatment with MFP, on the other hand, did not affect glucose homeostasis; plasma diffusible fluoride was always below 2 mumol/l. The results of these experiments indicate that glucose homeostasis is affected when plasma diffusible fluoride exceeds 5 mumol/l. The basal and glucose-stimulated insulin secretion of isolated Langerhans rat islets (incubated with solutions containing 2, 5, 10 and 20 mumol/l NaF) was significantly inhibited by 5 to 20 mumol/l fluoride. No effect was observed under similar conditions with MFP at concentrations of 2, 5, 10, 20 and 50 mumol/l.
authors.affiliation: Departamento de Ciencias Fisiológicas, Facultad de Ciencias Médicas, Rosario, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Rigalli
authors.forename: R
authors.initials: R
authors.lastname: Alloatti
authors.forename: I
authors.initials: I
authors.lastname: Menoyo
authors.forename: R C
authors.initials: RC
authors.lastname: Puche
mesh_terms: D000818:Animals; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects*; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology*
chemical_list: D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D005947:Glucose; D005459:Fluorides