Concurrent agranulocytosis and acute hepatitis resulting from combination of classic neuroleptics and subsequent successful clozapine treatment.
Agranulocytosis and hepatotoxic reactions are rare but severe side-effects of neuroleptic treatment. This article presents the case of a schizophrenic patient who concurrently developed agranulocytosis and acute hepatic drug reaction as a result of a combination of chemically different neuroleptic drugs. After restoration the patient was successfully treated with clozapine for six months without the hematologic disorders recurring.
Bauer
M
M
Department of Psychiatry, Freie Universität Berlin, Germany.
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced; D014150:Antipsychotic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D012559:Schizophrenia
D014150:Antipsychotic Agents; D003024:Clozapine