title: EPI imaging of global increase of brain MR signal with breath-hold preceded by breathing O2.
abstract: Brain MR signal has been observed to decrease during cessation of breathing due to the increase of deoxyhemoglobin in the blood. However, for both animal and human studies, we have demonstrated that if the subjects breathed 100% oxygen in advance of apnea for a short time, T2*-weighted MR brain signal increased when breathing was stopped for a period of 30-60 s. This demonstrates the possibility of measuring responses to hemodynamic change throughout the entire brain with a single respiratory perturbation in a rapid, reliable, and robust manner.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Kwong
authors.forename: I
authors.initials: I
authors.lastname: Wanke
authors.forename: K M
authors.initials: KM
authors.lastname: Donahue
authors.forename: T L
authors.initials: TL
authors.lastname: Davis
authors.forename: B R
authors.initials: BR
authors.lastname: Rosen
mesh_terms: D000818:Animals; D001049:Apnea / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D017352:Echo-Planar Imaging; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006935:Hypercapnia / Q000378:metabolism; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D010092:Oximetry; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D010101:Oxygen Consumption; D011817:Rabbits; D012119:Respiration
chemical_list: D006454:Hemoglobins; D002245:Carbon Dioxide; C100003:deoxyhemoglobin; D010100:Oxygen