Plasma interleukin-1 beta concentrations in panic disorder.
Plasma interleukin-1 beta (IL-1 beta) concentrations were measured in 10 outpatients with panic disorder before and on days 30 and 32 of treatment with alprazolam (2-2.5 mg/day). IL-1 beta concentrations were found to be significantly higher in patients than in control subjects both before and during therapy. Thus, IL-1 beta levels may be a marker of panic disorder that is not related to the current level of symptomatology.
Brambilla
F
F
Psychoneuroendocrine Center, Ospedale Psichiatrico Pini, Italy.
Bellodi
L
L
Perna
G
G
Bertani
A
A
Panerai
A
A
Sacerdote
P
P
D000328:Adult; D000525:Alprazolam / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000639:Amitriptyline / Q000627:therapeutic use; D000911:Antibodies, Monoclonal; D001007:Anxiety; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D016207:Cytokines; D007375:Interleukin-1; D001569:Benzodiazepines; D000639:Amitriptyline; D000525:Alprazolam