[A case of beneficial effect of ulinastatin on postoperative renal function in a patient with acute renal failure].
We experienced a case in which ulinastatin may have been beneficial to improve postoperative renal function in a patient with acute renal failure. The patient had acute renal failure with serum Cr of 9.3 mg.dl-1 after nephrectomy. On the 14th postoperative day, he underwent laparotomy under diagnosis of ileus. Administration of ulinastatin, 300,000 units.day-1 for 4 days, increased urine volume and creatine clearance and improved serum Cr level. This case suggests that ulinastatin might exert a beneficial effect on the recovery from renal tubular damage and on the glomerular filtration ratio, with resultant improvement of acute renal failure.
Ueki
M
M
Department of Anesthesiology and Emergency Medicine, Kagawa Medical School.
Yokono
S
S
Nogaya
J
J
Taie
S
S
Komatsu
H
H
Ogli
K
K
D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000503:physiopathology; D000368:Aged; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007680:Kidney Neoplasms / Q000601:surgery; D008297:Male; D009392:Nephrectomy; D011183:Postoperative Complications / Q000188:drug therapy* / Q000503:physiopathology
D006023:Glycoproteins; C028665:urinastatin