title: L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats.
abstract: L-745,337 [5-methanesulphonamido-6-(2,4-difluorothiophenyl)-1-indan one] a selective cyclooxygenase-2 inhibitor reversed hyperalgesia induced by carrageenan in rats without causing gastric ulceration at doses 100 times those causing antinociception. In contrast, piroxicam and indomethacin produced ulcerations at antinociceptive doses. These findings demonstrate that L-745,337 possesses antinociceptive activity but has a reduced liability for gastric ulceration.
authors.affiliation: Merck Sharp and Dohme Research Laboratory, Neuroscience Research Centre, Terlings Park, Harlow, Essex, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Boyce
authors.forename: C C
authors.initials: CC
authors.lastname: Chan
authors.forename: R
authors.initials: R
authors.lastname: Gordon
authors.forename: C S
authors.initials: CS
authors.lastname: Li
authors.forename: I W
authors.initials: IW
authors.lastname: Rodger
authors.forename: J K
authors.initials: JK
authors.lastname: Webb
authors.forename: N M
authors.initials: NM
authors.lastname: Rupniak
authors.forename: R G
authors.initials: RG
authors.lastname: Hill
mesh_terms: D000700:Analgesics / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D016861:Cyclooxygenase Inhibitors; D007189:Indans / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010894:Piroxicam / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D000700:Analgesics; D016861:Cyclooxygenase Inhibitors; D007189:Indans; C093700:L 745337; D010894:Piroxicam; D007213:Indomethacin