Kikuchi's disease as a presenting feature of mixed connective tissue disease.
Necrotising histiocytic lymphadenitis (Kikuchi's disease) is a recognised cause of benign lymphadenopathy. It has been reported in association with both adult Still's disease, systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCTD). We report a case of mixed connective tissue disease (MCTD), in which biopsy of enlarged lymph nodes occurring as a presenting feature showed the characteristic features of Kikuchi's disease. This finding supports the belief that Kikuchi's disease and the autoimmune rheumatic disorders may share a common aetiology.
Gourley
I
I
Department of Rheumatology, Musgrave Park Hospital, Belfast, Northern Ireland, UK.
Bell
A L
AL
Biggart
D
D
D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use
D003520:Cyclophosphamide; D011239:Prednisolone