Neurologic complications of Merkel cell carcinoma.
We describe a 61-year-old man with a multiple neurologic complication of Merkel cell carcinoma, a rare skin cancer. An enhancing brain mass, and cytologically proven leptomeningeal disease produced a succession of symptoms including seizures, bilateral radiculopathies, myoclonus, a cauda equina syndrome and altered mental status. Aggressive treatment prolonged his survival marginally.
Snodgrass
S M
SM
Department of Neurology, University Hospitals of Cleveland/Case Western Reserve School of Medicine, Ohio, USA.
Landy
H
H
Markoe
A M
AM
Feun
L
L
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000556:secondary*; D015266:Carcinoma, Merkel Cell / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology / Q000556:secondary*; D003561:Cytarabine / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000556:secondary*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology*; D012878:Skin Neoplasms / Q000473:pathology* / Q000503:physiopathology
D003561:Cytarabine; D002955:Leucovorin; D008727:Methotrexate