title: Gene targeting in mammalian cells by homologous recombination.
abstract: Gene targeting by homologous recombination is a genetic tool that permits modification of cellular genes in a precise and predetermined fashion. The methodologies that are currently available permit gene targeting at high efficiency and fidelity. New developments promise large-scale modification of the mammalian genome using these techniques.
authors.affiliation: Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461.
authors.forename: B
authors.initials: B
authors.lastname: Morrow
authors.forename: R
authors.initials: R
authors.lastname: Kucherlapati
mesh_terms: D000818:Animals; D001709:Biotechnology; D002460:Cell Line; D004274:DNA, Recombinant / Q000235:genetics; D005821:Genetic Techniques; D005822:Genetic Vectors; D051379:Mice; D016296:Mutagenesis; D011995:Recombination, Genetic; D013234:Stem Cells
chemical_list: D004274:DNA, Recombinant