title: The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene.
abstract: We show that the major role for Spo0A in the development of genetic competence is to downregulate expression of abrB. AbrB is both a negative regulator and a positive regulator of competence. The negative effects are exerted at multiple points in competence regulation. A regulatory mechanism that is independent of mecA and abrB operates on comK expression.
authors.affiliation: Public Health Research Institute, New York, New York 10016, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hahn
authors.forename: M
authors.initials: M
authors.lastname: Roggiani
authors.forename: D
authors.initials: D
authors.lastname: Dubnau
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology*; D001483:Base Sequence; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D015536:Down-Regulation / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D008969:Molecular Sequence Data; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*; D014169:Transformation, Bacterial / Q000235:genetics*
chemical_list: C060762:AbrB protein, Bacillus subtilis; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C080950:Spo0A protein, Bacillus subtilis; D014157:Transcription Factors