title: Anti-neutrophil cytoplasmic antibody for proteinase 3 in a child with polyarteritis nodosa.
abstract: We report a case of a 15 year old boy with polyarteritis nodosa associated with antineutrophil cytoplasmic antibody (ANCA) against proteinase 3 (PR3). After months of steroid and immunosuppressant therapy, the symptoms subsided and the polyaneurysms almost disappeared. The levels of anti-PR3 antibody and of cytokines also decreased. The results indicate that ANCA is a good indicator of this disease activity, and may play some pathogenic role in the disease.
authors.affiliation: Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: A
authors.initials: A
authors.lastname: Nishi
authors.forename: M
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: C
authors.initials: C
authors.lastname: Yasuoka
authors.forename: S
authors.initials: S
authors.lastname: Tomita
authors.forename: H
authors.initials: H
authors.lastname: Kato
mesh_terms: D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D016207:Cytokines / Q000097:blood; D006801:Humans; D008297:Male; D053146:Myeloblastin; D010488:Polyarteritis Nodosa / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D012697:Serine Endopeptidases / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; D016207:Cytokines; D012697:Serine Endopeptidases; D053146:Myeloblastin