Piperogalin, a new prenylated diphenol from Peperomia galioides.
A petroleum ether extract of Peperomia galoides showed significant in vitro activity against three Leishmania species and Trypanosoma cruzi. Three major prenylated diphenols, including two known compounds, grifolic acid [1], and grifolin [2], and the new substance piperogalin [3], have been isolated. Structures were established on the basis of spectral analysis including 2D nmr spectroscopy.
Mahiou
V
V
Laboratoire de Phamracognosie, Faculté de Pharmacie, Univerisité de Paris XI, France
Roblot
F
F
Hocquemiller
R
R
Cavé
A
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D012118:Resorcinols; C093894:piperogalin