Structure-activity relationships of synthetic methyl glycyrrhetate glycosides.
Of 15 synthetic methyl glycyrrhetate glycosides, the monoglycosides having CH2OH-6 or Me-6 in their sugar moieties and the diglycosides having a (1-->4) linkage between the sugar residues showed higher haemolytic activities than the others. The beta-maltoside and beta-lactoside exhibited much stronger antifungal activities against Trichophyton mentagrophytes than the others. However, none of them exhibited antibacterial activity against Staphylococcus aureus or Bacillus subtilis.
Takechi
M
M
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.
Tanaka
Y
Y
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006034:Glycyrrhetinic Acid / Q000737:chemistry* / Q000494:pharmacology; D008969:Molecular Sequence Data; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D006027:Glycosides; D006034:Glycyrrhetinic Acid