Enhancement of mutagenic activity of 9-aminoacridine by introducing a nitro group into the molecule.
Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its derivatives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.
Tomosaka
H
H
Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Japan.
Omata
S
S
Anzai
K
K
D000107:Acetylation; D000585:Aminacrine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D002855:Chromatography, Thin Layer; D004249:DNA Damage; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000378:metabolism; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009574:Nitro Compounds; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D009153:Mutagens; D009574:Nitro Compounds; C089475:9-amino-2-nitroacridine; D000585:Aminacrine