Pulmonary hemorrhage in children with glomerulonephritis.
Pulmonary hemorrhage may occur in patients with immune-mediated glomerulonephritis. This association can be seen in a variety of disorders including systemic lupus erythematosus, vasculitis, Wegener's granulomatosis, anaphylactoid purpura and Goodpasture's syndrome. Immune mechanisms, such as immune complexes and/or autoantibodies, play a role in the pathogenesis of pulmonary and glomerular injury. Acute pulmonary hemorrhage can lead to respiratory failure and has a high mortality. Therapy with immunosuppressive agents such as pulse methylprednisolone and cyclophosphamide will control the hemorrhage and improve pulmonary function in most cases.
Reznik
V M
VM
Department of Pediatrics, University of California School of Medicine, San Diego, California, USA.
Griswold
W R
WR
Lemire
J M
JM
Mendoza
S A
SA
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications*; D006470:Hemorrhage / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008171:Lung Diseases / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D003520:Cyclophosphamide; D011239:Prednisolone