title: Oceanapamine, a sesquiterpene alkaloid from the Philippine sponge Oceanapia sp.
abstract: The major metabolite of the Philippine sponge Oceanapia sp. is the antimicrobial alkaloid oceanapamine [1], which was isolated as a trifluoroacetate salt. The structure and the absolute configuration of oceanapamine, which consists of a monocyclic sesquiterpene attached to a histamine residue, were elucidated by interpretation of spectroscopic data.
authors.affiliation: Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093-0212, USA.
authors.forename: K G
authors.initials: KG
authors.lastname: Boyd
authors.forename: M K
authors.initials: MK
authors.lastname: Harper
authors.forename: D J
authors.initials: DJ
authors.lastname: Faulkner
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D012717:Sesquiterpenes; C093892:oceanapamine