[A pharmacokinetic study of korinfar-retard in monotherapy and in combination with cordanum and triampur in patients with arterial hypertension].
The long-acting corinfar formulation, corinfar-retard tablets, 20 mg (AWD, Germany), was studied for pharmacokinetics in single and course use in 40 patients with arterial hypertension, as well as for its effects of cordanum and triampur. Patients' plasma corinfar was measured by high performance liquid chromatography. There were no changes in the pharmacokinetics of the agent when it was used in its course use. Cordanum and triampur was demonstrated to have no effects on the pharmacokinetics of corinfar during their application.
Kukes
V G
VG
Ignat'ev
V I
VI
Kurapov
A P
AP
Pavlov
S S
SS
Rumiantsev
A S
AS
Chil'tsov
V V
VV
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002853:Chromatography, Liquid; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006801:Humans; D006852:Hydrochlorothiazide / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008875:Middle Aged; D009543:Nifedipine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011412:Propanolamines / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets; D013997:Time Factors; D014223:Triamterene / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D011412:Propanolamines; D013607:Tablets; D006852:Hydrochlorothiazide; C020743:hydrochlorothiazide-triamterene; C011550:talinolol; D009543:Nifedipine; D014223:Triamterene
Izuchenie farmakokinetiki korinfara-retard v monoterapii i v sochetanii s kordanumom i triampurom u bol'nykh s arterial'noĭ gipertenzieĭ.