title: Chordoma of the cranial base: the McGill experience.
abstract: Cranial base chrodoma, a rare, usually slow-growing tumour of bone thought to arise in notochord remnants, presents itself when its growth in the spheno-occiput results in cranial nerve compression or an obvious nasopharyngeal mass. The present review of 11 cases of cranial base chordoma encountered at three McGill University teaching hospitals from 1979 until 1992 examines presentation, radiologic findings, pathology, treatment, and outcome. A literature review surveys chrodoma with regard to epidemiology, diagnosis, efficacy of medical and surgical modalities on tumor control, and survival. Discussion focuses on current therapeutic options relative to histopathologic characteristics of chordoma, and whether or not these may be used to predict course of disease and outcome.
authors.affiliation: Montreal Neurologic Institute, Montreal General Hospital, Quebec.
authors.forename: B R
authors.initials: BR
authors.lastname: Mizerny
authors.forename: K M
authors.initials: KM
authors.lastname: Kost
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002817:Chordoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003391:Cranial Nerves / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome