Biotransformation of 18 beta-glycyrrhetinic acid by ginseng hairy root culture.
On administration of 18 beta-glycyrrhetinic acid to hairy root cultures of Panax ginseng, three new biotransformation products, 30-O-[beta-D-glucopyranosyl-(1-->2)-beta-D- glucopyranosyl]18 beta-glycyrrhetinic acid, 30-O-(6- O-malonyl-beta-D-glucopyranosyl)18 beta-glycyrrhetinic acid and 3-O-[6-O- malonyl-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl]18 beta-glycyrrhetinic acid, were isolated together with three known compounds. Ginseng hairy roots showed the biotransformation abilities of glycosylation and malonylation to 18 beta-glycyrrhetinic acid.
Asada
Y
Y
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Saito
H
H
Yoshikawa
T
T
Sakamoto
K
K
Furuya
T
T
D001711:Biotransformation; D002240:Carbohydrate Sequence; D046508:Culture Techniques; D006034:Glycyrrhetinic Acid / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D005894:Panax / Q000378:metabolism*; D010946:Plants, Medicinal
D006034:Glycyrrhetinic Acid