Study on hepatic artery chemoembolization using temperature-sensitive liposome or lipiodol emulsion.
As a novel method for the medical application of liposomes, we have tried hepatic artery chemoembolization using temperature-sensitive liposomes with hyperthermia for the treatment of hepatic tumors. In this study, the effect of temperature-sensitive liposomes was compared with that of Lipiodol emulsion, which has been used clinically. The temperature-sensitive liposomes, consisting of dipalmitoylphosphatidylcholine or Lipiodol emulsions entrapping doxorubicin, were administered into the hepatic artery of hepatic tumor-bearing rats via a cannula. Doxorubicin administered in a liposomal form showed a high accumulative property toward tumors, with heating, while that in the emulsion form showed a slow release property toward tumors. Not only was tumor growth inhibited, but also, an actual diminishing of the tumor was observed in each form. Side effects were also examined: an abnormal rise in GPT, or necrosis of the normal tissues in liver, which was often observed in hepatic artery chemoembolization using Lipiodol emulsion, was remarkably reduced in the liposomal chemoembolization.
Ono
A
A
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University, Japan.
Horikoshi
I
I
Ueno
M
M
D000818:Animals; D016461:Chemoembolization, Therapeutic; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004655:Emulsions; D006499:Hepatic Artery; D006979:Hyperthermia, Induced; D007459:Iodized Oil / Q000494:pharmacology*; D008081:Liposomes / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D004655:Emulsions; D008081:Liposomes; D007459:Iodized Oil; D004317:Doxorubicin