title: [Extensive ulceronecrotizing anorectitis caused by abuse of analgesic suppositories].
abstract: Usually considered as totally unoffensive, antalgic suppositories can, under certain conditions, lead to extensive anorectal injury with anatomic, functional and legal implications which we evaluated on the basis of two cases and a review of the literature. Clinicians, surgeons, pathologists and pharmaceutical firms should be aware of these pathophysiological events. Consumer information is required to reduce the risk of self-medication. There are characteristic psychologic situations and "dose-dependent" toxic effects which, as the saying goes "errare humanum est, perseverare diabolicum". Careful use of scientific knowledge and wise decisions by both experts and judges are required to avoid misinterpreting the pathogenesis of this particular anatomoclinical entity.
authors.affiliation: Service de Chirurgie Générale et Digestive, Hôpital Avicenne, Bobigny.
authors.forename: J P
authors.initials: JP
authors.lastname: Chevrel
authors.forename: P
authors.initials: P
authors.lastname: Vayre
authors.forename: R
authors.initials: R
authors.lastname: Parc
authors.forename: G
authors.initials: G
authors.lastname: Ferzli
authors.forename: K
authors.initials: K
authors.lastname: Keilani
mesh_terms: D000700:Analgesics; D001004:Anus Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D008875:Middle Aged; D009336:Necrosis; D012002:Rectal Diseases / Q000139:chemically induced*; D019966:Substance-Related Disorders; D013488:Suppositories; D014456:Ulcer / Q000139:chemically induced
chemical_list: D000700:Analgesics; D013488:Suppositories
vernacular_title: Ano-rectite ulcéronécrosante extensive par utilisation abusive de suppositoires contenant des produits antalgiques.