title: Large-scale processing of macromolecules.
abstract: Over the past year, a number of advances have been made in the large-scale purification of macromolecules, particularly proteins. Although refinements to individual unit operations have occurred, especially in improving the speed of operation and performance of large-scale chromatographic media, a major research thrust has been the development of processes in which steps are combined or eliminated to improve operability and reduce cost.
authors.affiliation: PerSeptive Biosystems Inc, Cambridge.
authors.forename: S P
authors.initials: SP
authors.lastname: Fulton
mesh_terms: D000327:Adsorption; D001688:Biological Products / Q000302:isolation & purification*; D001709:Biotechnology / Q000379:methods*; D011232:Chemical Precipitation; D002845:Chromatography / Q000379:methods; D005285:Fermentation; D011994:Recombinant Proteins / Q000302:isolation & purification; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D001688:Biological Products; D011994:Recombinant Proteins