title: Chromosomal localization of the gamma-glutamyl carboxylase gene at 2p12.
abstract: We have used two complementary approaches to analyze the chromosomal location of the gamma-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (PCR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. Mapping by fluorescence in situ hybridization assigned the gene to p12 of chromosome 2. Our results indicate that the gamma-glutamyl carboxylase gene has a single locus in the human genome.
authors.affiliation: Division of Molecular Cytometry, University of California at San Francisco 94103, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Kuo
authors.forename: D W
authors.initials: DW
authors.lastname: Stafford
authors.forename: J
authors.initials: J
authors.lastname: Cruces
authors.forename: J
authors.initials: J
authors.lastname: Gray
authors.forename: J
authors.initials: J
authors.lastname: Solera
mesh_terms: D000818:Animals; D001483:Base Sequence; D019735:Carbon-Carbon Ligases; D002889:Chromosomes, Human, Pair 2; D006224:Cricetinae; D003412:Cricetulus; D017931:DNA Primers; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008025:Ligases / Q000235:genetics*; D008969:Molecular Sequence Data
chemical_list: D017931:DNA Primers; D008025:Ligases; D019735:Carbon-Carbon Ligases; C020660:glutamyl carboxylase