Effects of a peroxisomal proliferator (PP) on plasma and tissue levels of coenzyme Q9 (CoQ), other antioxidants, and oxidative damage to DNA (oxo8dG): evidence that PPs deplete antioxidants and increase oxidative damage to DNA.
Youngman
L D
LD
Clinical Trial Service Unit, Radcliffe Infirmary, University of Oxford, UK.
Shigenaga
M
M
Motchnik
P
P
Ames
B N
BN
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000032:analysis; D001823:Body Composition / Q000187:drug effects; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000032:analysis; D008297:Male; D008830:Microbodies / Q000187:drug effects*; D009928:Organ Specificity; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D014451:Ubiquinone / Q000378:metabolism*; D014527:Uric Acid / Q000032:analysis; D014810:Vitamin E / Q000032:analysis
D000975:Antioxidants; D011743:Pyrimidines; D014451:Ubiquinone; D014810:Vitamin E; D014527:Uric Acid; C006253:pirinixic acid; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; C030571:ubiquinone 9; D001205:Ascorbic Acid