Quantitative liquid chromatographic thermospray-tandem mass spectrometric analysis of some analgesics and tranquilizers of the methadone, butyrophenone, or diphenylbutylpiperidine groups in whole blood.
The results of a liquid chromatographic-mass spectrometric method for the quantitative determination of some medicaments of the methadone, butyrophenone, or diphenylbutylpiperidine groups in whole blood are presented. The method includes an extraction procedure with Bond Elut columns. The liquid chromatograph is connected to a mass spectrometer by a thermospray interface, and to obtain as high a sensitivity and selectivity as possible, a selected reaction monitoring mass spectrometric technique in the daughter ion mode is applied.
Verweij
A M
AM
Department of General Chemistry, Forensic Science Laboratory of the Ministry of Justice, Rijswijk, The Netherlands.
Hordijk
M L
ML
Lipman
P J
PJ
D000700:Analgesics / Q000097:blood*; D014150:Antipsychotic Agents / Q000097:blood; D002090:Butyrophenones; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D013058:Mass Spectrometry; D008691:Methadone / Q000031:analogs & derivatives / Q000097:blood; D010880:Piperidines / Q000097:blood; D014149:Tranquilizing Agents / Q000097:blood*
D000700:Analgesics; D014150:Antipsychotic Agents; D002090:Butyrophenones; D010880:Piperidines; D014149:Tranquilizing Agents; D008691:Methadone