[Adipose tissue. Hidden aspects].
Adipose differentiation is a sequential process (adipoblasts-->preadipocytes-->adipocytes). Adipogenic factors are only involved in the terminal differentiation of preadipocytes to adipocytes by means of circulating hormones (growth hormone, glucocorticoids, insulin, triiodothyronine) and locally produced hormones (prostacyclin, IGF-I). Fatty acids also behave as hormones and act as transcriptional regulators of lipid-related genes. Once differentiated, adipocytes become secretory cells able to synthetize and release numerous peptide and nonpeptide compounds, suggesting a potential link between excess of adipose tissue mass and various physiopathologic consequences.
Ailhaud
G
G
Centre de Biochimie (UMR 134 CNRS), Université de Nice-Sophia Antipolis, Faculté des Sciences, Parc Valrose.
D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans
D005227:Fatty Acids; D006728:Hormones
Tissu adipeux. Facettes cachées.