Treatment of the stressogenic effect of dichlorvos.
1. Changes of corticosterone level in the plasma and tyrosine aminotransferase (TAT) in the liver following treated and untreated dichlorvos poisoning in rats were studied. 2. Corticosterone level during untreated poisoning was increased only. During treated dichlorvos poisoning and following antidotal treatment without poisoning, no significant changes of corticosterone level were observed. 3. Expressive increase of TAT activity in the third and 24th hour of untreated poisoning was demonstrated. Following treatment of dichlorvos poisoning with atropine, obidoxime and diazepam, the delayed and lower increase of TAT activity was observed. Following antidotal treatment without poisoning, no significant changes of TAT activity except its decrease in the third hour were demonstrated. 4. The treatment of dichlorvos poisoning practically eliminate stressogenic effects of dichlorvos. Moreover, the markers could be used for evaluating the effects of antidotes against organophosphate poisoning.
Kassa
J
J
Military Medical Academy Hradec Králové.
Bajgar
J
J
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D003345:Corticosterone / Q000097:blood; D003975:Diazepam / Q000627:therapeutic use; D004006:Dichlorvos / Q000506:poisoning*; D008099:Liver / Q000201:enzymology; D008297:Male; D009768:Obidoxime Chloride / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014444:Tyrosine Transaminase / Q000378:metabolism
D000931:Antidotes; D009768:Obidoxime Chloride; D001285:Atropine; D004006:Dichlorvos; D014444:Tyrosine Transaminase; D003975:Diazepam; D003345:Corticosterone