Activation of the basolateral Cl- conductance by cyclic AMP in rabbit renal proximal tubule S3 segment.
The regulation of basolateral Cl- conductance in renal proximal tubule was investigated by microelectrodes. Our results suggest that this conductance can be activated by cAMP, while increase in cell Ca2+ or activation of PKC has no effect. These properties of this conductance also suggest that CFTR may exist in the basolateral membrane of proximal tubule.
Seki
G
G
First Department of Internal Medicine, University of Tokyo, Japan.
Taniguchi
S
S
Uwatoko
S
S
Suzuki
K
K
Kurokawa
K
K
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology; D000818:Animals; D018118:Chloride Channels / Q000502:physiology*; D000242:Cyclic AMP / Q000494:pharmacology*; D003550:Cystic Fibrosis; D007668:Kidney / Q000502:physiology*; D008839:Microelectrodes; D011817:Rabbits
D018118:Chloride Channels; D000242:Cyclic AMP; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid