Prostaglandins which elevate cyclic AMP increase low density lipoprotein receptor mRNA and activity in human extra-hepatic cells.
Nield
H
H
Department of Biochemistry, University of Nottingham Medical School, U.K.
Middleton
B
B
D000527:Alprostadil / Q000494:pharmacology*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D011973:Receptors, LDL / Q000096:biosynthesis* / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D013873:Thionucleotides / Q000494:pharmacology; D015854:Up-Regulation
D012333:RNA, Messenger; D011973:Receptors, LDL; D013873:Thionucleotides; C016957:adenosine-3',5'-cyclic phosphorothioate; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D000527:Alprostadil