title: On the similarity between the small Cl- channel and the taurine channel activated after cell swelling in Ehrlich ascites tumor cells.
abstract: The swelling-activated Cl- efflux, mediated by the mini Cl- channel (3-7 pS), and the swelling-activated taurine efflux in Ehrlich cells are both inhibited by the anion channel blocker MK196 (indacrinone). The swelling-activated taurine efflux is also inhibited by DIDS and following depolarization of the cell membrane, but it is significantly stimulated by arachidonic acid in the micromolar range. The swelling-activated Cl- efflux is, in contrast, only slightly affected by DIDS, unaffected by the membrane potential, and completely blocked by arachidonic acid in the micromolar range. It is suggested that the swelling-activated mini Cl- channel and the taurine channel in the Ehrlich cells represent two distinct types of channels.
authors.affiliation: August Krogh Institute, University of Copenhagen, Denmark.
authors.forename: E K
authors.initials: EK
authors.lastname: Hoffmann
authors.forename: I H
authors.initials: IH
authors.lastname: Lambert
mesh_terms: D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D018118:Chloride Channels / Q000378:metabolism*; D007189:Indans / Q000494:pharmacology; D013654:Taurine / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D018118:Chloride Channels; D007189:Indans; D013654:Taurine; D016718:Arachidonic Acid; C013352:indacrinone; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid