title: [A study of ceftriaxone concentration in serum and tissue of patients with chronic sinusitis].
abstract: After an intravenous drip infusion of 1 g or 2 g of ceftriaxone (CTRX), its concentrations in serum and tissue were determined using the bioassay for 18 surgical patients with chronic paranasal sinusitis. 1. The serum levels observed at 75-105, 135-165, 195-225 minutes after an intravenous drip infusion of 1 g, averaged 98 +/- 38, 92 +/- 13 and 73 +/- 13 micrograms/ml, respectively. 2. The tissue levels at 75-105, 135-165, 195-225 minutes after an intravenous drip infusion of 1 g, averaged 27 +/- 13, 27 +/- 7 and 25 +/- 9 micrograms/g. 3. CTRX appears to be a useful drug for the treatment of chronic paranasal sinusitis.
authors.affiliation: Department of Otolaryngology, Yokohama Sakae Kyosai Hospital, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Nakagawa
authors.forename: H
authors.initials: H
authors.lastname: Kouno
authors.forename: M
authors.initials: M
authors.lastname: Tsukuda
authors.forename: S
authors.initials: S
authors.lastname: Sawaki
mesh_terms: D000328:Adult; D000368:Aged; D002443:Ceftriaxone / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012852:Sinusitis / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D002443:Ceftriaxone