Decreased urinary dopamine excretion and disturbed dopamine/sodium relationship in type 1 diabetes mellitus.
In Type 1 diabetes an increased total body sodium and an impaired ability to excrete a sodium load have been described. A possible involvement of the renal dopaminergic system in this abnormal sodium handling was evaluated through measurements of the urinary output of dopamine, sodium, the dopamine/sodium correlation, and through examining the effect of a dopamine infusion on urinary sodium excretion. Twenty-four hour urinary dopamine excretion was significantly lower in Type 1 diabetic patients as compared to normal controls. A significant correlation between urinary dopamine and sodium excretion was present in normoalbuminuric Type 1 diabetic patients and in normal controls. However, no such correlation could be found in microalbuminuric patients. The increase in fractional excretion of sodium during a 1 h low-dose dopamine (3 micrograms kg-1 min-1) infusion in Type 1 diabetic patients was negatively correlated with diabetes duration. Patients with short duration of diabetes (less than 15 years) had a comparable dopamine-induced increase in fractional excretion of sodium as normal controls. However, patients with longer duration of diabetes (more than 15 years) and microalbuminuric patients displayed no significant changes in sodium output during dopamine infusion. These findings suggest that in Type 1 diabetes mellitus a deficiency of renal dopamine production could be responsible for the impaired sodium handling. Longer duration of the disease and microalbuminuria seem to be associated with an uncoupling of the urinary dopamine/sodium relationship.
Segers
O
O
Department of Endocrinology and Internal Medicine, University Hospital, Brussels, Belgium.
Gerlo
E
E
Dupont
A G
AG
Somers
G
G
D000328:Adult; D000419:Albuminuria; D000704:Analysis of Variance; D015992:Body Mass Index; D016022:Case-Control Studies; D003404:Creatinine / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology / Q000652:urine*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012016:Reference Values; D012964:Sodium / Q000652:urine*; D013997:Time Factors
D003404:Creatinine; D004298:Dopamine; D006442:Glycated Hemoglobin; D012964:Sodium