Use of the gonadotropin-releasing hormone agonist triptorelin in the diagnosis of delayed puberty in boys.
To differentiate gonadotropin deficiency from delayed puberty in teenage boys, 0.1 mg/m2 of triptorelin, a gonadotropin-releasing hormone agonist, was administered subcutaneously at 4 AM. Serum gonadotropins and testosterone levels were determined at baseline and 4 hours after the injection. The increase in blood gonadotropin and testosterone levels was significantly greater in patients with delayed puberty than in those with gonadotropin deficiency.
Zamboni
G
G
Department of Pediatrics, University of Verona, Italy.
Antoniazzi
F
F
Tatò
L
L
D000293:Adolescent; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000172:deficiency; D006801:Humans; D007006:Hypogonadism / Q000097:blood* / Q000175:diagnosis; D007279:Injections, Subcutaneous; D007986:Luteinizing Hormone / Q000097:blood / Q000172:deficiency / Q000187:drug effects; D008297:Male; D011628:Puberty, Delayed / Q000097:blood / Q000175:diagnosis*; D013739:Testosterone / Q000097:blood / Q000172:deficiency; D013997:Time Factors; D017329:Triptorelin Pamoate / Q000008:administration & dosage
D017329:Triptorelin Pamoate; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone