title: Agraphia and acalculia after a left prefrontal (F1, F2) infarction.
abstract: A patient presented with agraphia and acalculia associated with a left frontal (F1, F2) infarction. He made mainly phonological but also lexical errors in writing (syllabograms), but his ability to write kanji (morphograms) was relatively preserved. Although he could add and subtract numbers, he could neither multiply nor divide them because of a difficulty in retrieving the multiplication tables and calculation procedures. Positron emission tomography showed decreased cerebral blood flow and metabolism limited to the infarct site. These findings suggest that agraphia and acalculia may occur associated with a left prefrontal lesion, and that the retrieval of arithmetic processes is modality specific.
authors.affiliation: Department of Neurology, Iwate Medical University, Morioka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tohgi
authors.forename: K
authors.initials: K
authors.lastname: Saitoh
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Utsugisawa
authors.forename: H
authors.initials: H
authors.lastname: Yonezawa
authors.forename: K
authors.initials: K
authors.lastname: Hatano
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000381:Agraphia / Q000209:etiology* / Q000473:pathology; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D014055:Tomography, Emission-Computed