[Interspecific differences in kemantan pharmacokinetics].
The pharmacokinetics of the new immunostimulant kemantane, adamantane derivative, used in two species of animals (rats and rabbits) and man was studied. There were significant differences in the pharmacokinetics of kemantane and its active metabolite--adamantane-1,4-diol between the species.
Boĭko
S S
SS
Zherdev
V P
VP
Kisliak
N A
NA
Piatin
B M
BM
Klimova
N V
NV
Glan
P V
PV
Dvorianinov
A A
AA
D000218:Adamantane / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D000276:Adjuvants, Immunologic / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001991:Bronchitis / Q000097:blood / Q000188:drug therapy; D002849:Chromatography, Gas; D002908:Chronic Disease; D006801:Humans; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D000276:Adjuvants, Immunologic; C068220:kemantane; D000218:Adamantane
Mezhvidovye razlichiia farmakokinetiki kemantana.