title: Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase.
abstract: Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.
authors.affiliation: Merck Research Laboratories, Rahway, NJ 07065.
authors.forename: R B
authors.initials: RB
authors.lastname: Lingham
authors.forename: K C
authors.initials: KC
authors.lastname: Silverman
authors.forename: G F
authors.initials: GF
authors.lastname: Bills
authors.forename: C
authors.initials: C
authors.lastname: Cascales
authors.forename: M
authors.initials: M
authors.lastname: Sanchez
authors.forename: R G
authors.initials: RG
authors.lastname: Jenkins
authors.forename: S E
authors.initials: SE
authors.lastname: Gartner
authors.forename: I
authors.initials: I
authors.lastname: Martin
authors.forename: M T
authors.initials: MT
authors.lastname: Diez
authors.forename: F
authors.initials: F
authors.lastname: Peláez
mesh_terms: D019883:Alkyl and Aryl Transferases; D005285:Fermentation; D008298:Maleates / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000378:metabolism*; D014166:Transferases / Q000037:antagonists & inhibitors*
chemical_list: D008298:Maleates; C080569:chaetomellic acid A; C085713:chaetomellic acid B; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase