Prediction of the maximal tolerated dose (MTD) and therapeutic effect of anticancer drugs in humans: integration of pharmacokinetics with pharmacodynamics and toxicodynamics.
Fuse
E
E
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd., Shizuoka-Ken, Japan.
Kobayashi
T
T
Inaba
M
M
Sugiyama
Y
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001682:Biological Availability; D001835:Body Weight; D004334:Drug Administration Schedule; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D011237:Predictive Value of Tests; D013045:Species Specificity; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents