title: Mercury toxicosis caused by ingestion of a blistering compound in a horse.
abstract: Mercury toxicosis by ingestion was diagnosed in a 3-year-old Quarter Horse mare with a history of anorexia and signs of abdominal discomfort. Ten and 9 days prior to admission, an inorganic mercuric blistering agent has been applied for topical treatment of dorsal metacarpal disease. At referral, signs of depression, dependent edema, pollakiuria, nonproductive cough, and oral ulceration were noticed. Laboratory data were consistent with renal dysfunction. Mercury content of blood and urine was high, confirming the diagnosis. The horse responded to intensive care, consisting primarily of IV fluid treatment, and mercury-chelating agents. However, acute laminitis developed, and the owners elected to euthanatize the horse 18 days after mercury exposure. Necropsy findings included renal tubulonephrosis and ulcerative colitis and enteritis. Mercury concentration was highest in kidney and liver tissues. The potential for mercury toxicosis in horses currently exists, and although the prognosis is grave, some horses may recover with appropriate treatment and long-term supportive medical care.
authors.affiliation: Department of Medicine and Surgery, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078.
authors.forename: M A
authors.initials: MA
authors.lastname: Guglick
authors.forename: C G
authors.initials: CG
authors.lastname: MacAllister
authors.forename: A M
authors.initials: AM
authors.lastname: Chandra
authors.forename: W C
authors.initials: WC
authors.lastname: Edwards
authors.forename: C W
authors.initials: CW
authors.lastname: Qualls
authors.forename: D H
authors.initials: DH
authors.lastname: Stephens
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy / Q000662:veterinary; D005534:Foot Diseases / Q000139:chemically induced / Q000662:veterinary; D006724:Hoof and Claw; D006734:Horse Diseases / Q000139:chemically induced* / Q000628:therapy; D006736:Horses; D007249:Inflammation / Q000139:chemically induced / Q000662:veterinary; D007422:Intestines / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D017669:Mercury Compounds / Q000008:administration & dosage / Q000506:poisoning*; D008630:Mercury Poisoning / Q000628:therapy / Q000662:veterinary*
chemical_list: D002614:Chelating Agents; D017669:Mercury Compounds