title: Production of an isonitrile antibiotic by an UV-induced mutant of Trichoderma harzianum.
abstract: Production of the antibiotic, homothallin II, by a UV-induced mutant strain of Trichoderma harzianum is reported, the wild-type parent of which was not an isonitrile antibiotic-producer. The compound has broad antibiotic activity against Oomycete, Ascomycete and Basidiomycete fungi, and both Gram-positive and -negative bacteria. The significance of the induction of homothallin II is discussed.
authors.affiliation: Department of Biology, Birkbeck College, University of London, U.K.
authors.forename: J L
authors.initials: JL
authors.lastname: Faull
authors.forename: K A
authors.initials: KA
authors.lastname: Graeme-Cook
authors.forename: B L
authors.initials: BL
authors.lastname: Pilkington
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002849:Chromatography, Gas; D003517:Cyclopentanes / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016296:Mutagenesis; D014242:Trichoderma / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000900:Anti-Bacterial Agents; D003517:Cyclopentanes; C090065:homothallin II