title: Flunitrazepam for sleep disturbance in children with intractable epilepsy.
abstract: Add-on therapy with flunitrazepam (FNZ) was performed in 5 children with marked sleep disturbance and intractable seizures. Correction of the sleep disturbance was attained immediately after the start of FNZ administration in all patients. Furthermore, a significant decrease in the seizure frequency (3 patients) and improved quality of life (4 patients) were concomitantly observed. There was no adverse effect or interaction with conventional AEDs on long-term use.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Konishi
authors.forename: K
authors.initials: K
authors.lastname: Masuko
authors.forename: Y
authors.initials: Y
authors.lastname: Naganuma
authors.forename: K
authors.initials: K
authors.lastname: Hongou
authors.forename: S
authors.initials: S
authors.lastname: Yagi
mesh_terms: D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications*; D005445:Flunitrazepam / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D005445:Flunitrazepam