title: Chlamydia pneumoniae-induced ciliostasis in ciliated bronchial epithelial cells.
abstract: The ciliary activity of ciliated bronchial epithelial cells was studied after infection with Chlamydia pneumoniae (strain TW-183) and Chlamydia trachomatis (biovar L2 [434/Bu]). C. pneumoniae, known to cause respiratory infections, had a marked ciliastatic effect, completely aborting ciliary motion within 48 h. This effect was not inhibited by inactivation of C. pneumoniae elementary bodies (EBs) by UV irradiation. In contrast, inactivation of EBs by heat (56 degrees C, 30 min) or by rabbit-specific immune sera to TW-183 antigen blocked the ciliastatic effect induced by C. pneumoniae infection. The effect of C. pneumoniae was specific. C. trachomatis, which causes sexually transmitted disease, did not block ciliary motion by 48 h after infection. A decrease in ciliary activity of ciliated bronchial cells produced by C. pneumoniae can contribute to both initiation and pathogenesis of respiratory infections induced by this pathogen.
authors.affiliation: Department of Virology, Soroka Medical Center, Faculty of the Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Shemer-Avni
authors.forename: D
authors.initials: D
authors.lastname: Lieberman
mesh_terms: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial / Q000276:immunology; D001980:Bronchi / Q000166:cytology / Q000382:microbiology* / Q000502:physiology; D002465:Cell Movement / Q000528:radiation effects; D002478:Cells, Cultured; D002692:Chlamydia trachomatis / Q000276:immunology / Q000502:physiology*; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000502:physiology*; D002923:Cilia / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D002479:Inclusion Bodies; D013045:Species Specificity; D014466:Ultraviolet Rays
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial