Abnormal distributions of T-lymphocyte subsets in the cerebrospinal fluid of patients with acute schizophrenia.
We analysed the percentages of CD4+ and CD8+ T lymphocytes in the cerebrospinal fluid (CSF) from 31 acutely ill schizophrenic patients. The psychotic patients had in their CSF clearly altered proportions of CD4+ and/or CD8+ T cells. As compared to the distribution of T cell subsets in the CSF from non-psychotic controls, the schizophrenic patients displayed both abnormally high and abnormally low frequencies of CD4+ and/or CD8+ cells. Changes in the distribution of T cell subsets corresponding to those seen in the CSF were not observed in paired blood samples from schizophrenic patients.
Nikkilä
H
H
Department of Psychiatry, Helsinki University, Finland.
Müller
K
K
Ahokas
A
A
Miettinen
K
K
Andersson
L C
LC
Rimón
R
R
D000208:Acute Disease; D000328:Adult; D015703:Antigens, CD / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D013601:T-Lymphocytes
D015703:Antigens, CD