title: A one year bioavailability study of coenzyme Q10 with 3 months withdrawal period.
abstract: Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coenzyme Q10 concentration increased from about 1 mg/l before supplementation to about 2 mg/l after 3 and 9 months of supplementation, and returned to the pretreatment level after withdrawal. The rise of coenzyme Q10 concentration was statistically significant (P < 0.001, t-test).
authors.affiliation: Institute for Biomedical Research, University of Texas at Austin, USA.
authors.forename: K
authors.initials: K
authors.lastname: Folkers
authors.forename: S
authors.initials: S
authors.lastname: Moesgaard
authors.forename: M
authors.initials: M
authors.lastname: Morita
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D001682:Biological Availability; D002214:Capsules; D003067:Coenzymes; D005500:Follow-Up Studies; D005780:Gelatin; D006801:Humans; D013024:Soybean Oil; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D002214:Capsules; D003067:Coenzymes; D014451:Ubiquinone; D013024:Soybean Oil; D005780:Gelatin; C024989:coenzyme Q10