A changing pattern in the association of oral contraceptives and the different groups of congenital limb deficiencies.
A case-control study on different groups of isolated congenital limb deficiency was performed in a ten-year population-based and revised Hungarian data set. A higher rate of one contraceptive pill type with relatively high dose (ethynodiol diacetate 1.0 mg + ethinyloestradiol 0.05 mg) used in the periconceptional period was found in the mothers of cases with terminal transverse defect (adjusted relative odds 1.9 with 95% confidence interval of 1.1-3.4). This risk is minimised by the use of recent low-dose pills.
Czeizel
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AE
Department of Human Genetics and Teratology, National Institute of Hygiene, Budapest, Hungary.
Kodaj
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I
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000328:Adult; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004997:Ethinyl Estradiol / Q000009:adverse effects; D005040:Ethynodiol Diacetate / Q000009:adverse effects; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D007231:Infant, Newborn; D017880:Limb Deformities, Congenital; D008297:Male
D003276:Contraceptives, Oral; D004997:Ethinyl Estradiol; D005040:Ethynodiol Diacetate