Organization of organelles and membrane traffic by microtubules.
Organelles of the central membrane system of higher eukaryotes have been shown to utilize microtubules both for maintenance of their characteristic spatial distributions and for efficient transport of their protein and lipid to diverse sites within the cell. Recent work addressing the mechanisms that underlie this organization provides new insights regarding the roles of microtubules and microtubule motors in influencing organelle dynamics and specific membrane traffic routes through the cytoplasm.
Cole
N B
NB
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Lippincott-Schwartz
J
J
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D011992:Endosomes / Q000378:metabolism / Q000648:ultrastructure; D005057:Eukaryotic Cells; D007425:Intracellular Membranes / Q000378:metabolism* / Q000648:ultrastructure; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D015388:Organelles / Q000648:ultrastructure*; D010766:Phosphorylation