Inhibition by nifedipine of the efflux of plasma low-density lipoprotein and albumin from the vasculature of the mouse mesentery in vivo.
Efflux and extravascular accumulation of intravenously administered fluorescent-labeled low-density lipoprotein (LDL) and albumin were measured in superfused mouse mesenteric preparation in anesthetized mice. Pretreatment of animals with nifedipine (1 and 3 mg/kg sc) significantly reduced both the extravascular accumulation of LDL (measured by fluorescence densitometry) and the efflux (measurement of the tracers in the superfusate) of both LDL and albumin. These effects may help to explain the possible anti-atherogenic effect of nifedipine.
Görög
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William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, England.
Born
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GV
D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects* / Q000502:physiology; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects*; D008297:Male; D008643:Mesentery / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008856:Microscopy, Fluorescence; D009543:Nifedipine / Q000494:pharmacology*; D012709:Serum Albumin / Q000187:drug effects* / Q000378:metabolism
D008077:Lipoproteins, LDL; D012709:Serum Albumin; D009543:Nifedipine