[Dose-dependent haloperidol modulation of the amplitude-time characteristics of the thalamo-cortical responses of the rabbit sensorimotor cortex in ontogeny].
The fact of marked neuroleptic modulation of the amplitude-temporal parameters of thalamo-cortical responses (TCR) of the sensorimotor cortex (SMC) in the range of "the therapeutic haloperidol window" and the psychotoxical phase was established in early postnatal ontogeny of rabbits. The gradual increase of blood haloperidol concentration was accompanied by non-harmonic increasing variations of the level of neuroleptic modulation of the amplitudes of separate TCR components. These dose-dependent variations with alternation of depression and potentiation of TCR components were observed not only in psychotoxical phase, but also inside "the therapeutic haloperidol window". In retarded, infantile individuals the lower threshold of haloperidol modulation of amplitude parameters of TCR SMC was observed in comparison with normally developing animals. In contrast to the amplitude parameters, dose-dependent modulation of latent periods of different components of TCR SMC was not of oscillatory but exponential character. This can testify to participation of different (by electrogenesis, biochemistry, and structure) neuronal pools in the processes of neuroleptically induced reorganization of amplitude and time markers of TCR SMC.
Shimko
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IA
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006130:Growth Disorders / Q000503:physiopathology; D006220:Haloperidol / Q000494:pharmacology*; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D013788:Thalamus / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D006220:Haloperidol
Dozozavisimaia galoperidolovaia moduliatsiia amplitudno-vremennýkh kharakteristik talamo-kortikal'nykh otvetov sensomotornoĭ kory u krolika v ontogeneze.