A novel GPI-anchored glycoprotein shows properties of a COOH-terminus truncated cadherin involved in cell-cell contacts of cultured human epithelial cells.
We report the characterization of a cell-cell adhesion molecule identified by mAb BD31 on human epithelioid cells. This glycoprotein shows cadherin features but appears to be truncated being devoid of the transmembrane and cytoplasmic domains. It is directly membrane-anchored by a GPI moiety. We propose to call this molecule HT-cadherin.
Trusolino
L
L
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Rabino
M
M
Prat
M
M
Cremona
O
O
Savoia
P
P
Marchisio
P C
PC
D000911:Antibodies, Monoclonal; D000941:Antigens; D001709:Biotechnology; D015820:Cadherins / Q000276:immunology / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D004847:Epithelial Cells; D006023:Glycoproteins / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D017261:Glycosylphosphatidylinositols / Q000737:chemistry; D006801:Humans
D000911:Antibodies, Monoclonal; D000941:Antigens; D015820:Cadherins; D006023:Glycoproteins; D017261:Glycosylphosphatidylinositols