Synthesis and activity of dipeptides containing epsilon-aminocaproic acid.
Five new dipeptides containing epsilon-aminocaproic acid were synthesized. All dipeptides markedly inhibit fibrinolytic activity of plasmin but only in low concentration (0.0002M). In higher concentration fibrinolytic activity was observed. Activity of dipeptides containing epsilon-aminocaproic acid, which antifibrinolytic activity is known, was tested on plasmin, thrombin, urokinase and euglobulin fraction using synthetic substrates.
Midura-Nowaczek
K
K
Institute of Chemistry, Warsaw University, Bialystok, Poland.
Bruzgo
I
I
Roszkowska-Jakimiec
W
W
Worowski
K
K
D000577:Amides / Q000378:metabolism; D015119:Aminocaproic Acid / Q000737:chemistry*; D000933:Antifibrinolytic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002364:Caseins / Q000378:metabolism; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D005342:Fibrinolysis / Q000187:drug effects*; D005916:Globulins / Q000187:drug effects / Q000378:metabolism; D006868:Hydrolysis / Q000187:drug effects; D010958:Plasminogen / Q000037:antagonists & inhibitors; D013300:Streptokinase / Q000494:pharmacology; D013917:Thrombin / Q000187:drug effects / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000187:drug effects / Q000378:metabolism
D000577:Amides; D000933:Antifibrinolytic Agents; D002364:Caseins; D004151:Dipeptides; D005916:Globulins; D010958:Plasminogen; D013300:Streptokinase; D013917:Thrombin; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator; D015119:Aminocaproic Acid