title: [Human bone marrow cell culture--a sensitive method for the evaluation of the biocompatibility of materials used in orthopedics].
abstract: The objective of the study was to develop a test system to determine the cytotoxicity and biocompatibility of different biomaterials used in orthopedic surgery. This system was based on the use of a human bone marrow cell culture and the purpose was to find a screening method as a alternative to early animal experimental methods. The established human bone marrow cell culture has certain advantages when compared with other cell culture models. The result demonstrated a high conformity with animal experimental results.
authors.affiliation: Orthopädische Klinik, Philipps-Universität Marburg.
authors.forename: A
authors.initials: A
authors.lastname: Wilke
authors.forename: S
authors.initials: S
authors.lastname: von Hirschheydt
authors.forename: J
authors.initials: J
authors.lastname: Orth
authors.forename: H
authors.initials: H
authors.lastname: Kienapfel
authors.forename: P
authors.initials: P
authors.lastname: Griss
authors.forename: R P
authors.initials: RP
authors.lastname: Franke
mesh_terms: D001672:Biocompatible Materials / Q000032:analysis*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence
chemical_list: D001672:Biocompatible Materials
vernacular_title: Die humane Knochenmarkszellkultur--Eine sensitive Methode zur Beurteilung der Biokompatibilität von Materialien, die in der Orthopädie verwendet werden.