Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy.
An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electrophysiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of processes of the dorsal root ganglion cells.
McLachlan
R S
RS
Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London.
Brown
W F
WF
D000200:Action Potentials; D000293:Adolescent; D004594:Electrophysiology; D004827:Epilepsy / Q000188:drug therapy*; D005727:Ganglia, Spinal; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D011736:Pyridoxine / Q000009:adverse effects / Q000494:pharmacology*; D012640:Seizures; D012678:Sensation Disorders; D013977:Tibia
D011736:Pyridoxine