title: Construction and screening of biological peptide libraries.
abstract: Significant advances have been made recently in technology to construct and screen peptide libraries using biological systems. Progress has been achieved in increasing the size of libraries, in controlling affinity of the peptides isolated, and in understanding the constraints imposed by the biology of the expression systems employed. New receptor ligands and substrates for peptide-modifying enzymes have been isolated using these powerful techniques.
authors.affiliation: Affymax Research Institute, Palo Alto.
authors.forename: P J
authors.initials: PJ
authors.lastname: Schatz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D016208:Databases, Factual; D004798:Enzymes / Q000378:metabolism*; D004926:Escherichia coli; D006801:Humans; D009838:Oligodeoxyribonucleotides; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D004798:Enzymes; D009838:Oligodeoxyribonucleotides; D010455:Peptides; D004247:DNA