title: Mismatch repair and cancer susceptibility.
abstract: Mismatch-repair systems have been identified in organisms ranging from Escherichia coli to humans. They can repair almost all DNA base pair mismatches as well as small insertion/deletion mismatches. Molecular and biochemical analyses have shown that the core components of eukaryotic mismatch-repair systems are highly homologous to their bacterial counterparts. In humans, defects in four mismatch-repair genes have been linked both to hereditary non-polyposis colorectal cancer and to spontaneous cancers that exhibit rearrangements in DNA containing simple repeat sequences.
authors.affiliation: Dana Farber Cancer Institute, Boston.
authors.forename: R D
authors.initials: RD
authors.lastname: Kolodner
authors.forename: E
authors.initials: E
authors.lastname: Alani
mesh_terms: D004260:DNA Repair / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D009692:Nucleic Acid Heteroduplexes; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D009692:Nucleic Acid Heteroduplexes