title: Efficacy of steroid hormone in solution for intracranial irrigation during aneurysmal surgery for prevention of the vasospasm syndrome.
abstract: A series of 55 patients with ruptured cerebral aneurysms were treated with moderate removal of subarachnoid clot followed by intracranial irrigation with pH 8.0 Hartmann solution containing 1 mg/ml of methylpredonisolone sodium succinate after the aneurysmal clipping during early (before day 3) operation. Six (11%) of the 55 patients suffered vasospasm syndrome postoperatively. The clinical results are significantly better than a series of 68 patients operated on and treated before day 3 by intracranial irrigation with Hartmann solution (pH 8.0) only. The possible preventive effect of direct intracranial administration of steroid hormone is discussed.
authors.affiliation: Department of Neurosurgery, Hirosaki University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Ogane
authors.forename: M
authors.initials: M
authors.lastname: Souma
authors.forename: H
authors.initials: H
authors.lastname: Ohkuma
authors.forename: T
authors.initials: T
authors.lastname: Iwabuchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000601:surgery*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D007431:Intraoperative Complications / Q000517:prevention & control*; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage*; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013345:Subarachnoid Hemorrhage / Q000601:surgery; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
chemical_list: D008776:Methylprednisolone Hemisuccinate