Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma.
Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper. Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.
Ferrara
F
F
Cattedra di Anatomia e Istologia Patologica, Università degli Studi di Milano, IRCCS H. San Raffaele, Italy.
De Santis
L
L
Mangili
F
F
Sassi
I
I
Luchini
S
S
Mandelli
C
C
Santambrogio
G
G
Cantaboni
A
A
D000230:Adenocarcinoma / Q000737:chemistry* / Q000235:genetics / Q000401:mortality; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000032:analysis*; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000401:mortality; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
D004273:DNA, Neoplasm; D018719:Erb-b2 Receptor Tyrosine Kinases