Serine carboxypeptidases: a new and versatile family of enzymes.
Several structural and biochemical studies in the past year have revealed the potential application of a new family of serine proteinase, the serine carboxypeptidases, in peptide synthesis, carboxy-terminal peptide sequencing and the production of biologically active carboxy-terminal peptide amides. The recent determination of the high-resolution crystal structures for two members of the family, CPDW-II and CPDY, should permit protein engineering to further increase their utility.
Remington
S J
SJ
Institute of Molecular Biology, University of Oregon, Eugene 97403.
D001665:Binding Sites; D001709:Biotechnology; D002268:Carboxypeptidases / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry; D017421:Sequence Analysis
D010455:Peptides; D011506:Proteins; D002268:Carboxypeptidases; C022633:serine carboxypeptidase