[Primary culture of different renal cell carcinoma cells with respect to immunomodulatory effects].
The presented results show that renal cell carcinomas (RCC) have partial immunomodulatory capacity (production of cytokines as IL-6, -10, -11; modulation of mitogen-induced transformation of T lymphocytes). The production of IL-10 shows a tendency to correlate with higher staging and grading of RCC. The cytokine production does not correlate with specific types of RCC. Direct immunosuppression of T lymphocytes in lymphocyte transformation tests (LTT) was not detectable.
Knöfel
B
B
Institut für Klinische Immunologie, Universität Jena.
Junker
U
U
Nuske
K
K
el-Seweifi
A
A
Junker
K
K
Kosmehl
H
H
Jäger
L
L
D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000473:pathology; D003470:Culture Media; D006801:Humans; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000378:metabolism* / Q000494:pharmacology; D017370:Interleukin-11 / Q000378:metabolism* / Q000494:pharmacology; D015850:Interleukin-6 / Q000378:metabolism* / Q000494:pharmacology; D008213:Lymphocyte Activation; D014407:Tumor Cells, Cultured
D003470:Culture Media; D017370:Interleukin-11; D015850:Interleukin-6; D016753:Interleukin-10
Untersuchungen von Primärkulturen verschiedener Nierenzellkarzinome (NZK) in Hinblick auf immunmodulatorische Effekte.