title: [Conservative treatment of sub-clinical noninfiltrating cancers of the breast (102 EOA in situ, TONO)].
abstract: 102 patients with sub-clinical intra ductal non invasive breast cancer (T0N0) treated by limited surgery and curative radiation therapy. Follow-up ranged from 2 to 10 years with a median follow-up of 59 months. The long term survival rate of this therapeutic approach, consisting of simple excision without any adjuvant treatment and radical mastectomy was close to 100%. The actuarial local recurrence rate was only 8.6% at 10 years (confidence interval: 4.6 to 12.6%), which strongly suggests that radiation therapy is active on multicentric foci. Salvage surgery could be performed in every case of local recurrence. The survival rate of in situ breast cancer (T0N0) treated by conservative radio-surgery is comparable to that of radical mastectomy, while cosmetic results and psychological impact appear to be better for the conservative technique (breast preservation rate = 91 to 96%).
authors.affiliation: Académie Méditerranéene d'Oncologie Clinique, Polyclinique Clairval, Marseille.
authors.forename: H
authors.initials: H
authors.lastname: Brandone
authors.forename: Y
authors.initials: Y
authors.lastname: Ayme
authors.forename: D
authors.initials: D
authors.lastname: Hans
authors.forename: A
authors.initials: A
authors.lastname: Dubau
authors.forename: J M
authors.initials: JM
authors.lastname: Brandone
authors.forename: F
authors.initials: F
authors.lastname: Robert
authors.forename: J F
authors.initials: JF
authors.lastname: Pollet
authors.forename: F
authors.initials: F
authors.lastname: Amalric
authors.forename: C
authors.initials: C
authors.lastname: Bressac
authors.forename: J
authors.initials: J
authors.lastname: Jacquemier
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D002278:Carcinoma in Situ / Q000532:radiotherapy / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015413:Mastectomy, Simple; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local
vernacular_title: Le traitement conservateur des cancers du sein infra-cliniques canalaires non infiltrants (102 EOA in situ, TONO).