Biotransformation in Egyptian spiny mouse Acomys cahirinus.
The activities of several representative biotransformation enzymes were determined in male and female spiny mouse tissues. Cytochrome P450 monooxygenase activity toward benzo(a)pyrene was significantly greater in female spiny mouse intestine than in males. Activity toward benzphetamine in both sexes was high in the liver, with little activity in the kidney and intestine. Sulfotransferase activity was high in kidney and intestine of female spiny mice but undetectable in the same tissues in males. Hepatic glutathione S-transferase activity towards 1-chloro-2,4-dinitrobenzene in females was significantly higher than in males. UDP-Glucuronosyltransferase activity toward 1-naphthol in both sexes in the kidney was significantly higher than hepatic and intestinal activity. Intestinal N-acetyltransferase activity towards 2-aminofluorene and beta-naphthylamine was significantly greater in females than males. No consistent relation appeared to exist between biotransformation activities in spiny mouse and those in other related rodent species.
Watkins
J B
JB
Medical Sciences Program, Indiana University School of Medicine, Bloomington 47405-4201.
LaFollette
J W
JW
Sanders
R A
RA
D015081:2-Naphthylamine / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism / Q000633:toxicity; D001589:Benzphetamine / Q000378:metabolism / Q000633:toxicity; D001711:Biotransformation; D003374:Coumarins / Q000378:metabolism / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004137:Dinitrochlorobenzene / Q000633:toxicity; D004851:Epoxide Hydrolases / Q000378:metabolism; D004852:Epoxy Compounds / Q000378:metabolism / Q000633:toxicity; D004976:Ethacrynic Acid / Q000378:metabolism / Q000633:toxicity; D005260:Female; D005449:Fluorenes / Q000378:metabolism / Q000633:toxicity; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000201:enzymology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008745:Methylation; D009115:Muridae; D009284:Naphthols / Q000633:toxicity; D010078:Oxazines / Q000633:toxicity; D010105:Oxygenases / Q000378:metabolism; D012737:Sex Factors
D003374:Coumarins; D004137:Dinitrochlorobenzene; D004852:Epoxy Compounds; D005449:Fluorenes; D009284:Naphthols; D010078:Oxazines; D001589:Benzphetamine; C029350:1-naphthol; D001564:Benzo(a)pyrene; C012177:2-aminofluorene; C007649:ethoxyresorufin; D003577:Cytochrome P-450 Enzyme System; C013690:styrene oxide; C030123:coumarin; D015081:2-Naphthylamine; D010105:Oxygenases; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases; D004976:Ethacrynic Acid