Brain phagocytes and the microglia of the cerebral cortex of rats following an incident of total ischaemia.
The aim of the study was to point out the presence of phagocytes and active microglial cells in the cerebral cortex of rats that survived from 6 weeks to 12 months after clinical death. The number of perivascular phagocytes increased with the period of time survived after reanimation. These cells were found to be multipotential, they participated in the enzymatic degradation of cellular elements damaged in the course of clinical death. In areas distant from the capillary vessels the presence of many forms of microglial cells was revealed. The majority of them belonged the dendrous microglia. Their numerous cytoplasmic processes proved their ability to migrate. The results of the study show an increase of pathological processes in the brain, which is proportional to the length of time survival after reperfusion following cardiac arrest. The main participants in this process are the perivascular phagocytes and active cells of the dendrous microglia.
Walski
M
M
Laboratory of the Ultrastructure of the Nervous System, Polish Academy of Sciences, Warsaw.
Borowicz
J
J
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002470:Cell Survival; D002540:Cerebral Cortex / Q000473:pathology*; D008297:Male; D017628:Microglia; D010586:Phagocytes; D051381:Rats; D017208:Rats, Wistar