title: Rett syndrome: the bcl-2 gene--a mediator of neurotrophic mechanisms?
abstract: Rett syndrome affects young girls. The molecular basis is mysterious. One tenable hypothesis can be that the programmed early infantile death of neuronal cells is reprogrammed. The bcl-2 gene on chromosome 22 has been shown to play a role in the apoptosis process. No sequence abnormalities were detected in the bcl-2 gene of 6 patients with Rett syndrome which could explain the pathophysiology of Rett syndrome.
authors.affiliation: Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Anvret
authors.forename: Z P
authors.initials: ZP
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Hagberg
mesh_terms: D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002892:Chromosomes, Human, Pair 22; D017931:DNA Primers; D005260:Female; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D015518:Rett Syndrome / Q000235:genetics*
chemical_list: D017931:DNA Primers