title: Partial blocking of NMDA receptors restricts plastic changes in adult mouse barrel cortex.
abstract: Changes of cortical body maps can be evoked in brains of adult animals by injury to sensory nerves. We investigated changes of functional representation of row C of mystacial vibrissae in the barrel cortex of mice. Plastic changes of cortical representations were mapped with 2-deoxyglucose autoradiography. Seven days after lesions of all vibrissae except row C, cortical representation of the spared row increased in width by 60%. Partial blocking of N-methyl-D-aspartate (NMDA) receptors by subdural implants of thin sheets of Elvax impregnated with DL-2-amino-5-phosphonovaleric acid (APV) prevented development of the increase of row C representation. Low level of NMDA receptor blocking did not affect significantly the basal level of 2DG uptake and stimulus evoked uptake but prevented the plastic change of the body map.
authors.affiliation: Department of Neurophysiology, Nencki Institute, Warsaw, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Jabłońska
authors.forename: M
authors.initials: M
authors.lastname: Gierdalski
authors.forename: E
authors.initials: E
authors.lastname: Siucińska
authors.forename: J
authors.initials: J
authors.lastname: Skangiel-Kramska
authors.forename: M
authors.initials: M
authors.lastname: Kossut
mesh_terms: D000818:Animals; D001345:Autoradiography; D001786:Blood Glucose / Q000378:metabolism*; D001931:Brain Mapping; D003847:Deoxyglucose / Q000378:metabolism; D007091:Image Processing, Computer-Assisted; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation*
chemical_list: D001786:Blood Glucose; D016194:Receptors, N-Methyl-D-Aspartate; D003847:Deoxyglucose