Large increase in plasmatic 11-dehydro-TxB2 levels due to oral contraceptives.
Coagulation factors, 11-dehydro-TxB2 (metabolite of TxA2) and 6-keto-PGF1 alpha (metabolite of PGI2) levels in 87 women who were treated for 9 months with oral contraceptives (OC) containing low doses of oestrogens and progestogens (Triquilar, Trinovum or Cilest) were investigated. In plasma, increases in F I, II, VII, VIII-c and 11-dehydro-TxB2 levels, but no modification of 6-keto-PGF1 alpha were observed. In urine, FPA concentration rose, but no change occurred in 11-dehydro-TxB2 and 6-keto-PGF1 alpha levels. No marked difference between the 3 OC preparations were noted. These data, and particularly the large increase of 11-dehydro-TxB2 (p < 0.01) suggest that a hypercoagulable state persists in low dosage OC users.
Schlit
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AF
Haemostasis Unit, Saint-Luc University Hospital, Brussels, Belgium.
Grandjean
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P
Donnez
J
J
Lavenne
E
E
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D000704:Analysis of Variance; D003276:Contraceptives, Oral / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D016912:Levonorgestrel / Q000494:pharmacology; D009640:Norethindrone / Q000494:pharmacology; D009644:Norgestrel / Q000031:analogs & derivatives / Q000494:pharmacology; D011516:Prothrombin / Q000032:analysis; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000097:blood
D003276:Contraceptives, Oral; D009644:Norgestrel; D004997:Ethinyl Estradiol; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D016912:Levonorgestrel; C049235:11-dehydro-thromboxane B2; D005167:Factor VII; D011516:Prothrombin; D005169:Factor VIII; D005340:Fibrinogen; C017576:norgestimate; D009640:Norethindrone