In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates.
Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-beta-D-glucopyranoside, and 13 beta, 18-dihydroeurycomanol possessed antimalarial activity with IC50 values of 1.231-4.899 microM, 0.389-3.498 microM, and 0.504-2.343 microM, respectively, compared with 0.323-0.774 microM for chloroquine.
Ang
H H
HH
Chan
K L
KL
Mak
J W
JW
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D036702:Quassins
C093530:13,18-dihydroeurycomanol; D000962:Antimalarials; D036702:Quassins; C093531:eurycomanol 2-O-glucopyranoside; C093532:eurycomanol; D002738:Chloroquine; D005900:Glaucarubin