title: Combinatorial chemistry--applications of light-directed chemical synthesis.
abstract: Combinatorial methods in biology and chemistry are proving to be powerful methods for generating molecular diversity. One approach, light-directed chemical synthesis, combines semiconductor-based photolithography technologies with solid-phase organic chemistry to synthesize large arrays of molecules with potential biological activity. This novel technology has the potential to provide libraries of both natural and synthetic molecules that might be screened rapidly for biological activity.
authors.affiliation: Affymax Research Institute, Palo Alto, CA 94304.
authors.forename: J W
authors.initials: JW
authors.lastname: Jacobs
authors.forename: S P
authors.initials: SP
authors.lastname: Fodor
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001709:Biotechnology / Q000379:methods; D002219:Carbamates / Q000737:chemistry; D004247:DNA / Q000235:genetics; D004399:Dynorphins / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000235:genetics; D004723:Endorphins / Q000138:chemical synthesis / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000235:genetics; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000235:genetics; D010777:Photochemistry / Q000379:methods*
chemical_list: D002219:Carbamates; D004723:Endorphins; D009841:Oligonucleotides; D010455:Peptides; D004399:Dynorphins; C036200:rimorphin; D004247:DNA