title: The chromatin-associated protein H-NS.
abstract: H-NS is a major component of chromatin in enteric bacteria. H-NS plays a structural role in organising the chromosome, and influences DNA rearrangements as well as the expression of many genes. The biochemical and functional characteristics of H-NS are distinct from those of 'typical' DNA-binding proteins and much remains to be learned about the mechanism(s) by which H-NS acts. In this article we review our current understanding of the role of H-NS, and describe possible models by which H-NS might influence DNA structure and gene expression.
authors.affiliation: Imperial Cancer Research Fund Laboratories, University of Oxford, John Radcliffe Hospital, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Ussery
authors.forename: J C
authors.initials: JC
authors.lastname: Hinton
authors.forename: B J
authors.initials: BJ
authors.lastname: Jordi
authors.forename: P E
authors.initials: PE
authors.lastname: Granum
authors.forename: A
authors.initials: A
authors.lastname: Seirafi
authors.forename: R J
authors.initials: RJ
authors.lastname: Stephen
authors.forename: A E
authors.initials: AE
authors.lastname: Tupper
authors.forename: G
authors.initials: G
authors.lastname: Berridge
authors.forename: J M
authors.initials: JM
authors.lastname: Sidebotham
authors.forename: C F
authors.initials: CF
authors.lastname: Higgins
mesh_terms: D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry*; D001426:Bacterial Proteins; D002843:Chromatin / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000737:chemistry*; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation; D010641:Phenotype; D011485:Protein Binding
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; C031908:H-NS protein, bacteria; D046911:Macromolecular Substances