title: Neonatal infraorbital nerve transection and blockade of axoplasmic transport reduce expression of acetylcholinesterase by thalamocortical axons.
abstract: Acetylcholinesterase (AChE) is transiently expressed by ventrobasal thalamic neurons and their axons in the primary somatosensory cortex and this enzyme has been used as a marker for these axons in studies concerned with cortical development and plasticity. The present experiment evaluated the effects of both peripheral nerve transection and blockade of axoplasmic transport upon the expression of AChE in thalamic axon terminals in the primary somatosensory cortex. Both manipulations resulted in marked reductions in the density of AChE in thalamocortical axons and less dramatic decreases in the density of this enzyme in thalamic neurons. These results indicate that AChE may not invariably provide unequivocal information about the distribution of somatosensory thalamocortical axon terminals in developing rodents.
authors.affiliation: Department of Anatomy and Neurobiology, Medical College of Ohio, Toledo 43699-0008, USA.
authors.forename: N L
authors.initials: NL
authors.lastname: Chiaia
authors.forename: R W
authors.initials: RW
authors.lastname: Rhoades
authors.forename: C A
authors.initials: CA
authors.lastname: Bennett-Clarke
mesh_terms: D000110:Acetylcholinesterase / Q000235:genetics* / Q000502:physiology; D000818:Animals; D001369:Axons; D001921:Brain / Q000254:growth & development*; D006801:Humans; D007231:Infant, Newborn; D009412:Nerve Fibers / Q000502:physiology*; D051381:Rats; D013003:Somatosensory Cortex / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*
chemical_list: D000110:Acetylcholinesterase