title: Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy.
abstract: We studied the feasibility of characterizing brain tumor tissue by localized proton magnetic resonance spectroscopy (1H-MRS). Twenty-six newly diagnosed tumors were examined by in-vivo 1H-MRS. The NAA (N-acetylaspartate)/Cho (choline) ratio of Grade 2 astrocytoma was higher than that of Grade 4. The Cho/Cr (creatine and phosphocreatine) ratio of meningioma was considerably higher than that of glioma of all grades. We have experienced only two cases of ependymoma and the Cho/Cr ratios of both were lower than that of glioma. It seems likely that 1H-MRS can be used to differentiate Grade 2 from Grade 4 in most cases of astrocytoma based on the NAA/Cho ratio, though a few cases will overlap. Meningioma can be distinguished easily from glioma, and the results of our study suggest that ependymoma shows a characteristic pattern on 1H-MRS, different from those of other brain tumors.
authors.affiliation: Department of Radiology, School of Medicine, University of Tokushima.
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Tanouchi
authors.forename: H
authors.initials: H
authors.lastname: Nishitani
authors.forename: H
authors.initials: H
authors.lastname: Miyoshi
authors.forename: K
authors.initials: K
authors.lastname: Bandou
authors.forename: S
authors.initials: S
authors.lastname: Kannuki
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001254:Astrocytoma / Q000737:chemistry / Q000473:pathology; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D004806:Ependymoma / Q000737:chemistry / Q000473:pathology; D005910:Glioma / Q000737:chemistry / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008579:Meningioma / Q000737:chemistry / Q000473:pathology; D010725:Phosphocreatine / Q000032:analysis
chemical_list: D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline