Genetic techniques in the diagnosis of carcinomas of the kidney.
The term "carcinoma of the kidney" includes four types of cancer with distinct morphological and cytogenetic characteristics. It is likely that each type of kidney carcinoma is caused by mutation in a different gene. Families with inherited carcinomas of the kidney provide a guide to the isolation of these genes. The gene responsible for the commonest form of kidney carcinoma has been isolated by study of families with von Hippel-Lindau disease (VHL). The VHL gene is mutated in the commonest form of kidney carcinoma and in the germ line of patients with VHL. The VHL gene is a powerful tool for the study of the biology and diagnosis of kidney cancer.
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Laboratory of Immunobiology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702, USA.
D018076:DNA, Complementary / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D018740:Genetic Heterogeneity; D005854:Germ Cells; D018095:Germ-Line Mutation; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics; D015394:Molecular Structure; D010641:Phenotype
D018076:DNA, Complementary; D008565:Membrane Proteins