title: Treatment with two growth hormone regimens in girls with Turner syndrome: final height results. Dutch Growth Hormone Working Group.
abstract: In 1987 a multicentre trial of recombinant human growth hormone (GH) was started in girls with Turner syndrome. Fifty-four patients were randomly assigned to receive GH, 8 IU/m2 3 times/week (group 1), or 4 IU/m2 6 times/week (group 2). In addition, the 35 patients older than 12 years received ethinyloestradiol, 100 ng/kg body weight/day, and after 2 years GH therapy was increased to 6 IU/m2 6 times/week. Recombinant human GH treatment was stopped when the height increment during the previous 6 months of treatment was less than 0.5 cm. Treatment has so far been stopped in 48 patients: treatment was stopped early in 2 patients due to lack of motivation, 1 patient died suddenly and the treatment protocol was completed in 45 patients. The last height measurement obtained, which was considered as (near) final height, was 152.3 +/- 5.3 cm (mean +/- SD) in these patients, which is higher (p < 0.001) than the adult height of 147.0 +/- 6.3 cm reported in 63 untreated adult Dutch patients with Turner syndrome. No differences in outcome were found between the two dose regimens.
authors.affiliation: Department of Paediatrics, University of Leiden, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Massa
authors.forename: B J
authors.initials: BJ
authors.lastname: Otten
authors.forename: S M
authors.initials: SM
authors.lastname: de Muinck Keizer-Schrama
authors.forename: H A
authors.initials: HA
authors.lastname: Delemarre-van de Waal
authors.forename: M
authors.initials: M
authors.lastname: Jansen
authors.forename: T
authors.initials: T
authors.lastname: Vulsma
authors.forename: W
authors.initials: W
authors.lastname: Oostdijk
authors.forename: J J
authors.initials: JJ
authors.lastname: Waelkens
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
mesh_terms: D001827:Body Height / Q000187:drug effects*; D001846:Bone Development / Q000187:drug effects; D002648:Child; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D009426:Netherlands; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014424:Turner Syndrome / Q000188:drug therapy*
chemical_list: D011994:Recombinant Proteins; D004997:Ethinyl Estradiol; D013006:Growth Hormone