[Effectiveness of liposomal antibacterial drugs in the inhalation therapy of experimental tuberculosis].
The model of generalized tuberculosis in BALB/c mice was used to compare efficacy of daily and intermittent (2 times a week) regimens of ultrasound inhalation therapy. This employed water-soluble and liposomal dosages of antituberculous drugs. The highest effect was achieved in daily inhalations of liposomal drugs. In spite of the fact that intermittent regime of the liposomal drugs required a 2-fold lowered dosage, its efficacy was not inferior to daily water-soluble drug therapy and was only by 22% less than maximum. High response to liposomal form stems from prolonged persistence of high rifampicin concentrations in pulmonary tissue.
Kurunov
Iu N
IuN
Ursov
I G
IG
Krasnov
V A
VA
Petrenko
T I
TI
Iakovchenko
N N
NN
Svistelńik
A V
AV
Filimonov
P A
PA
D000280:Administration, Inhalation; D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004338:Drug Combinations; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014465:Ultrasonics
D000995:Antitubercular Agents; D004337:Drug Carriers; D004338:Drug Combinations; D008081:Liposomes
Effectivnost liposomalńoĭ lekarstvennoĭ formy antibakterialńykh preparatov v ingaliatsionnoĭ terapii éksperimentalńogo tuberkulëza.