Is there a carryover effect of mild ovarian hyperstimulation with gonadotropins on the subsequent cycle?
OBJECTIVE
To investigate the effect of mild ovarian hyperstimulation on hormonal and sonographic variables of the subsequent natural cycle.


METHODS
Prospective study of three consecutive cycles.


METHODS
University Hospital, Department of Reproductive Medicine, Division of Obstetrics and Gynecology.


METHODS
Twelve couples with subnormal semen as the only identifiable cause of subfertility.


METHODS
Subjects were offered IUI for three cycles. In the second cycle, mild ovarian hyperstimulation with 75 IU IM hMG was applied daily and ovulation was induced with 5,000 IU hCG. In the first and third both natural cycles, serum samples were obtained for hormone measurements and ultrasound (US) scanning of the ovaries was performed.


METHODS
To determine whether there was a carryover effect of mild ovarian hyperstimulation as applied in the second cycle, hormone levels and US scans of cycle 3 were compared with those of cycle 1.


RESULTS
None of the variables of cycle 3 were significantly different from those of cycle 1.


CONCLUSIONS
Because hormonal and sonographic variables in the subsequent natural cycle remain unchanged, a carryover effect of mild ovarian hyperstimulation with gonadotropins seems unlikely.
Cohlen
B J
BJ
Department of Reproductive Medicine, University Hospital Utrecht, The Netherlands.
te Velde
E R
ER
Wissmann
D
D
van Kooij
R J
RJ
van Zonneveld
P
P
Habbema
J D
JD
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008596:Menotropins / Q000008:administration & dosage / Q000627:therapeutic use*; D010053:Ovary / Q000502:physiology; D010062:Ovulation Induction; D011446:Prospective Studies
D006063:Chorionic Gonadotropin; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone