[The "vitamin D" endocrine and paracrine mediator in pulmonary granulomatosis].
This paper reports the recent data concerning the role of vitamin D in pulmonary granulomatous disease. Besides the well known action of 1,25-(OH)2D3 in producing hypercalcaemia in these patients, it is envisaged that 1,25-(OH)2D3 probably has an activating effect through a paracrine pathway on the formation and maturation of granulomas at the pulmonary level.
Cadranel
J
J
Service de Pneumologie et de Réanimation Respiratoire, Hôpital Tenon, Paris.
D002117:Calcitriol / Q000502:physiology; D002118:Calcium / Q000502:physiology; D006099:Granuloma / Q000503:physiopathology*; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology*; D012507:Sarcoidosis / Q000503:physiopathology; D014397:Tuberculosis, Pulmonary / Q000503:physiopathology; D014807:Vitamin D / Q000502:physiology*
D014807:Vitamin D; D002117:Calcitriol; D002118:Calcium
La "vitamine D" médiateur endocrine et paracrine au cours des granulomatoses pulmonaires.