title: [Current status of the activity of 5-HT3 receptor antagonists in animal pharmacology].
abstract: Most tests used for the screening of 5-HT3 receptor antagonists are not completely specific but they give satisfactory results when they are used in battery. In cancer chemotherapy and radiotherapy, 5-HT3 receptor antagonists are very active against acute emesis but delayed and anticipatory vomiting remains difficult to cure. Potential activities of 5-HT3 receptor antagonists as neuroleptics, anxiolytics and agents useful against dependence and cognitive disorders pose some problems in animal psychopharmacology and remain to be clinically validated.
authors.affiliation: Synthelabo Recherche, Bagneux.
authors.forename: G
authors.initials: G
authors.lastname: Raynaud
mesh_terms: D000818:Animals; D000932:Antiemetics; D002415:Cats; D004195:Disease Models, Animal; D004285:Dogs; D066298:In Vitro Techniques; D011619:Psychotropic Drugs; D051381:Rats; D012702:Serotonin Antagonists / Q000494:pharmacology*
chemical_list: D000932:Antiemetics; D011619:Psychotropic Drugs; D012702:Serotonin Antagonists
vernacular_title: Bilan actuel de l'activité des antagonistes des récepteurs 5-HT3 en pharmacologie animale.