Estrogen dependent LDH-Y, a new LDH isozyme and fertility factor in mice uterus during early pregnancy.
In estrogen treated ovariectomized and pregnant mice on the first day after mating a sixth LDH isozyme appeared at Relative mobility (Rm) 0.08 to 0.15 and for convenience this isozyme is provisionally designated as LDH-Y. The appearance of a sixth LDH isozyme (LDH-Y) in mice uterus after ovariectomy and estrogen treatment favours the idea that this isozyme is estrogen dependent. Presence of this LDH-Y in mice uterus during preimplantation and finally its sudden disappearance during implantation and post implantation periods further suggest that LDH-Y is estrogen dependent and responsible for restoring fertility in mice.
Singh
P P
PP
University Department of Zoology, Bhagalpur University, India.
Singh
V N
VN
Sirmour
S K
SK
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D010064:Embryo Implantation; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D051379:Mice; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology; D014599:Uterus / Q000378:metabolism*
D007527:Isoenzymes; D011374:Progesterone; D004958:Estradiol; D007770:L-Lactate Dehydrogenase