title: Analysis of ketorolac in postmortem blood.
abstract: This paper describes analytical methods using high-performance liquid chromatography and gas chromatography-mass spectrometry (GC-MS) for the isolation of the nonsteroidal anti-inflammatory drug, ketorolac. The drug is isolated from postmortem blood using a batched solid-phase extraction method on Amberlite XAD-2 resin. Derivatization of ketorolac using diazopropane was necessary prior to GC-MS analysis. The methods were applied in the investigation of a death occurring shortly after the administration of an intramuscular injection of ketorolac tromethamine. Death was attributed to an adverse reaction to the drug, resulting in anaphylaxis and cardiac arrest.
authors.affiliation: Washington State Toxicology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle 98134, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Logan
authors.forename: P N
authors.initials: PN
authors.lastname: Friel
authors.forename: K L
authors.initials: KL
authors.lastname: Peterson
authors.forename: D B
authors.initials: DB
authors.lastname: Predmore
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000097:blood / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004342:Drug Hypersensitivity / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007273:Injections, Intramuscular; D020910:Ketorolac; D020911:Ketorolac Tromethamine; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning; D014325:Tromethamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000506:poisoning
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D014046:Tolmetin; D020910:Ketorolac