Insulin receptors on the endolymphatic sac: an autoradiographic study.
Light microscopic autoradiographs were prepared of isolated guinea pig endolymphatic sac (ES) tissue incubated with iodine (I)-125-labeled insulin (insulin I 125). These demonstrated specific binding of the insulin I 125 to receptors in the ES. Receptor-mediated endocytosis of the insulin-receptor complex is postulated to occur, and the relevance of insulin receptors in the ES is discussed, with particular emphasis on the previously observed synthesis of hyaluronan from glucose by the ES.
Knight
L C
LC
Department of Otolaryngology, University of California, San Francisco 94143-0526, USA.
Saeed
S R
SR
Hradek
G T
GT
Schindler
R A
RA
D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D004705:Endocytosis; D004712:Endolymphatic Sac / Q000737:chemistry*; D006168:Guinea Pigs; D007328:Insulin; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin / Q000032:analysis*
D007328:Insulin; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin