title: In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile.
abstract: Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl. and their structures were identified to be 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which the former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV-3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukemia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 x 10(6) cells of sarcoma 180.
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: J D
authors.initials: JD
authors.lastname: Park
authors.forename: N I
authors.initials: NI
authors.lastname: Baek
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
authors.forename: B Z
authors.initials: BZ
authors.lastname: Ahn
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes