Marine natural products as a source of novel pharmacological agents.
Research into marine natural products is evolving from an empirical search for antimicrobial and cytotoxic compounds into a more mechanistic approach to the discovery of enzyme inhibitors and receptor antagonists with therapeutic potential. Several marine natural products have entered pharmaceutical development and others are making significant contributions to our understanding of cellular processes at the biochemical level.
Carté
B K
BK
Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification; D000970:Antineoplastic Agents / Q000302:isolation & purification; D001688:Biological Products / Q000302:isolation & purification*; D001709:Biotechnology; D004791:Enzyme Inhibitors / Q000302:isolation & purification; D007166:Immunosuppressive Agents / Q000302:isolation & purification; D008386:Marine Biology; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D011956:Receptors, Cell Surface