Prenatal toxicity of heptachlor in albino rats.
Exposure of the cyclodiene insecticide heptachlor at 1/8 and 1/4 LD50 to male and female albino rats before mating affected fertility in both sexes. A decrease in implantations, serum oestrogen and progesterone levels and increase in resorptions in the females was observed. However, no histological changes were observed except for few atretic follicles in the treated females. In males, a dose-dependent significant decrease in the sperm count and coagulating gland fructose levels was observed, with marginal degeneration of seminiferous tubules. These results are indicative of the prenatal toxicity of heptachlor in male and female rats.
Rani
B E
BE
Infestation Control and Protectants Department, Central Food Technological Research Institute, Mysore, India.
Krishnakumari
M K
MK
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000097:blood; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006533:Heptachlor / Q000633:toxicity*; D006801:Humans; D008297:Male; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013737:Testis / Q000187:drug effects
D004967:Estrogens; D011374:Progesterone; D006533:Heptachlor