title: Transgenic mice with deficiencies in cartilage collagens: possible models for gene therapy.
abstract: We address three issues that are important when considering somatic gene therapy approaches to osteoarthritis (OA) and related syndromes. First, only those diseases for which a precise molecular etiology has been established should be contemplated for somatic gene therapy. Second, DNA sequences should be identified that restrict expression of correcting genes to chondrocytes; we discuss the use of transgenic mice to identify such sequences. Third, we emphasize the usefulness of establishing animal models that mimic human OA syndromes by genetic manipulations. These transgenic models should be essential for testing gene therapy approaches in vivo.
authors.affiliation: M.D. Anderson Cancer Center, Department of Molecular Genetics, University of Texas, Houston 77030, USA.
authors.forename: B
authors.initials: B
authors.lastname: de Crombrugghe
authors.forename: P
authors.initials: P
authors.lastname: Katzenstein
authors.forename: K
authors.initials: K
authors.lastname: Mukhopadhyay
authors.forename: V
authors.initials: V
authors.lastname: Lefebvre
authors.forename: G
authors.initials: G
authors.lastname: Zhou
authors.forename: S
authors.initials: S
authors.lastname: Garofalo
authors.forename: M
authors.initials: M
authors.lastname: Metsäranta
authors.forename: R
authors.initials: R
authors.lastname: Rosati
authors.forename: E
authors.initials: E
authors.lastname: Vuorio
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000737:chemistry; D003094:Collagen / Q000172:deficiency / Q000235:genetics; D004195:Disease Models, Animal; D015870:Gene Expression; D015316:Genetic Therapy; D051379:Mice; D008822:Mice, Transgenic; D010003:Osteoarthritis / Q000235:genetics / Q000628:therapy; D010009:Osteochondrodysplasias / Q000235:genetics / Q000628:therapy
chemical_list: D003094:Collagen