Improvement of multifocal motor neuropathy during long-term weekly treatment with human immunoglobulin.
In multifocal motor neuropathy (MMN), little is known of the long-term effect of human immunoglobulin (HIG) infusions as a maintenance therapy. We report a patient who improved after an initial HIG infusion of 2 g/kg and continued to improve both clinically and electrophysiologically during maintenance HIG treatment consisting of one infusion of 0.4 g/kg every week. Our findings suggest that maintenance HIG therapy may lead to further improvement of MMN, and that more frequent HIG infusions at a lower dosage may be more effective.
Van den Berg
L H
LH
Department of Neurology, Rudolf Magnus Research School in the Neurosciences, University Hospital Utrecht, The Netherlands.
Franssen
H
H
Wokke
J H
JH
D000328:Adult; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D016472:Motor Neuron Disease / Q000503:physiopathology / Q000628:therapy*; D009132:Muscles / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D013997:Time Factors
D016756:Immunoglobulins, Intravenous