title: Glial uptake of intracerebroventricularly injected D-serine in the rat brain: an immunocytochemical study.
abstract: Recent studies have shown that free D-serine, an agonist for the N-methyl-D-aspartate receptor, is present in the forebrain of rats. In present study, we raised antibodies against D-serine and examined the distribution of both endogenous and intracerebroventricularly administered D-serine in the rat forebrain by an immunocytochemical method. D-Serine-like immunoreactive cells were found in glial cells in the brains of the rats injected with D-serine into the lateral ventricle. No immunoreactive cells were seen in the brains of untreated rats. The results suggest that glial cells may accumulate and catabolize D-serine to regulate the concentration of this neuroactive amino acid in the forebrain.
authors.affiliation: Department of Anatomy II, Mie University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Wako
authors.forename: N
authors.initials: N
authors.lastname: Ma
authors.forename: T
authors.initials: T
authors.lastname: Shiroyama
authors.forename: R
authors.initials: R
authors.lastname: Semba
mesh_terms: D000818:Animals; D003337:Corpus Callosum; D007150:Immunohistochemistry / Q000379:methods*; D007278:Injections, Spinal; D008297:Male; D009457:Neuroglia / Q000502:physiology*; D016548:Prosencephalon / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012694:Serine / Q000378:metabolism*
chemical_list: D012694:Serine