A pilot study of cyclosporine for the prevention of postsurgical adhesion formation in rats.
OBJECTIVE
Our purpose was to evaluate the efficacy of cyclosporine in preventing primary postsurgical adhesions in the rat model.


METHODS
Thirty-two Sprague-Dawley rats underwent unilateral uterine horn injury with a combination of unipolar and bipolar cautery. Sixteen of the rats were randomized to the treatment group and received preoperative and daily cyclosporine dosing (10 mg/kg) by gavage for 14 days. At the end of the study all animals were killed, and a standard adhesion scoring system was applied by a blinded examiner.


RESULTS
Adhesions were present in 75% of rats in both groups. Treatment did not affect the total adhesion score.


CONCLUSIONS
Cyclosporine does not appear promising as a means to decrease postsurgical adhesion formation.
Leondires
M P
MP
Department of Obstetrics and Gynecology, Maine Medical Center, Portland 04102, USA.
Stubblefield
P G
PG
Tarraza
H M
HM
Jones
M A
MA
D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control; D014591:Uterine Diseases / Q000517:prevention & control*
D016572:Cyclosporine