A new subclass of alkaloids from a dendrobatid poison frog: a structure for deoxypumiliotoxin 251H.
Deoxypumiliotoxin 251H [4], representing a new subclass of the pumiliotoxin-A class of alkaloids, has been isolated from a dendrobatid frog, Epipedobates tricolor. The structure, elucidated by nmr, gc-Ftir, and mass spectral analyses, is proposed to be an 8-methyl-6-(5-hydroxy-2-methylhexylidene)-1-azabicyclo[4.3.0]nonan e. The absolute stereochemistry and the relative configuration of the hydroxyl group are unknown.
Jain
P
P
Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0820.
Garraffo
H M
HM
Spande
T F
TF
Yeh
H J
HJ
Daly
J W
JW
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D001001:Anura; D002849:Chromatography, Gas; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D017550:Spectroscopy, Fourier Transform Infrared
D000470:Alkaloids; C093761:deoxypumiliotoxin 251H