[The effect of conditions of storage and composition of viral material on lipid peroxidation of the viral envelope and inactivation of the influenza virus].
Lipid peroxidation (LPO) develops in the virus envelopes in the course of storage of influenza virus suspensions. It is registered by fluorescent methods by the time course of intermediate products (short-chain dialdehydes) and final products of LPO (fluorescent pigment), this being characteristic of an autocatalytic process. The conformity of the basic regularities of LPO and virus inactivation in samples differing by the storage conditions, concentrations of virions and antioxidants (alpha-tocopherol acetate and phenosan) permits us to consider LPO as an important mechanism of enveloped virus inactivation during storage.
Poryvaev
V D
VD
Zykova
N A
NA
D000818:Animals; D002642:Chick Embryo; D009980:Influenza A virus / Q000502:physiology*; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D011309:Preservation, Biological; D014759:Viral Envelope Proteins / Q000737:chemistry*
D014759:Viral Envelope Proteins
Vliianei usloviĭ khraneniia i sostava virusnogo materiala na perekis noe okislenie lipidov virusnoĭ obolochki i inaktivatsiiu virusa grippa.