title: Bilateral breast carcinoma: mammographic and histologic correlation.
abstract: OBJECTIVE
  To determine the mammographic, histologic, and clinical features of bilateral breast cancer.
  
  
  METHODS
  Pre-biopsy mammograms of 67 patients with bilateral carcinoma were reviewed. Lesions were synchronous in 35 patients and metachronous in 32. Mammographic appearance, lesion size and location, and bilateral similarities were evaluated. Axillary nodal status was noted. These characteristics were compared with those of unilateral cancers.
  
  
  RESULTS
  Of 58 mammographically evident lesion pairs, 31 involved the same quadrant. Of the total 67 lesion pairs, 24 pairs were similar in appearance, and 15 had both mirror image location and a similar appearance. Of 17 lesion pairs considered to represent a single primary carcinoma with metastases to the contralateral breast, eight had a similar mirror image appearance and five had mirror image location and a similar mirror image appearance. The second cancer of metachronous pairs was smaller, with less frequent axillary nodal involvement.
  
  
  CONCLUSIONS
  The appearance of bilateral breast cancer does not differ from that of unilateral carcinoma. Bilateral breast carcinomas frequently demonstrate a similar mammographic appearance and mirror image location.
authors.affiliation: Department of Radiology, Thomas Jefferson University Hospital, Jefferson Medical College, Philadelphia, Pa. 19107, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Murphy
authors.forename: E F
authors.initials: EF
authors.lastname: Conant
authors.forename: C A
authors.initials: CA
authors.lastname: Hanau
authors.forename: S M
authors.initials: SM
authors.lastname: Ehrlich
authors.forename: S A
authors.initials: SA
authors.lastname: Feig
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies