title: Inhibitory effects of aspirin on coronary hyperreactivity to autacoids after arterial balloon injury in miniature pigs.
abstract: We examined the effects of aspirin on coronary hyperreactivity to autacoids after arterial balloon injury in miniature pigs. Coronary vasoconstriction induced by histamine and serotonin were examined angiographically before, 1 h, 1 week, and 1 month after balloon injury in 29 hypercholesterolemic miniature pigs. The animals were divided into three groups: group A, no treatment (n = 16); group B, pretreated with aspirin 50 mg/day for 2 days before injury (n = 7); and group C, treated with aspirin 50 mg/day for 2 days before and 5 days after injury (7 days in all) (n = 6). In group A, coronary vasoconstriction induced by autacoids was significantly greater at the injured than at the noninjured site at all times examined (p < 0.01). Hyperconstriction induced by the autacoids 1 h after injury were significantly less in groups B and C than in group A (p < 0.01). Hyperconstriction induced by autacoids 1 week after injury were significantly less in group B than in group A (p < 0.01) and were significantly less in group C than in group A (p < 0.01) or group B (p < 0.05). Treatment with aspirin for 2 or 7 days had no effect on the constrictive responses at the injured site 1 month after injury or on those at the noninjured site at all times examined. These results suggest that platelet-vessel wall interaction may play an important role in coronary hyperconstrictive responses to autacoids 1 h and 1 week after injury.
authors.affiliation: Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kuga
authors.forename: Y
authors.initials: Y
authors.lastname: Ohara
authors.forename: H
authors.initials: H
authors.lastname: Shimokawa
authors.forename: S
authors.initials: S
authors.lastname: Ibayashi
authors.forename: H
authors.initials: H
authors.lastname: Tomoike
authors.forename: A
authors.initials: A
authors.lastname: Takeshita
mesh_terms: D000792:Angiography; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D012898:Autacoids / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003251:Constriction, Pathologic / Q000188:drug therapy; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013552:Swine; D013556:Swine, Miniature; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D012898:Autacoids; D012701:Serotonin; D006632:Histamine; D005996:Nitroglycerin; D001241:Aspirin