title: Subcortical modulation of synaptic plasticity in the hippocampus.
abstract: A two-stage model of memory trace formation in the hippocampus considers exploratory behavior associated with theta activity and consumatory behaviors or immobility associated with the occurrence of synchronous pyramidal cell discharges. Threshold, frequency and extent of CA3 bursts differ between differently performing strains of mice and are subject to subcortical modulation. Mechanisms for such actions are described: interference with potassium and other cation channels through second messengers and a direct action of histamine on the NMDA receptor channel. Furthermore long-lasting potentiations of synaptic transmission and excitability following brief exposures of hippocampal slices to histamine, noradrenaline, and serotonin are mediated by cyclic AMP and presumably protein kinase A.
authors.affiliation: Institute of Physiology II, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: H L
authors.initials: HL
authors.lastname: Haas
authors.forename: O A
authors.initials: OA
authors.lastname: Sergueeva
authors.forename: V S
authors.initials: VS
authors.lastname: Vorobjev
authors.forename: I N
authors.initials: IN
authors.lastname: Sharonova
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D046508:Culture Techniques; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D015290:Second Messenger Systems / Q000502:physiology; D013045:Species Specificity; D013569:Synapses / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents