title: Evaluation of a new rate adaptive ventricular pacemaker controlled by double sensors.
abstract: The LEGEND-PLUS, a new rate adaptive pacemaker that combines activity and minute ventilation sensing for automatic rate adaptation was implanted in the right ventricle (VVIR) in 11 patients (mean age 62 +/- 9 years). Initial programming was performed using the Programmer Exercise Protocol (a 3-minute walk). This programming was evaluated by treadmill tests, up-stairs and down-stairs walking, and Holter recordings.
  
  
  RESULTS
  Following the final programming of LEGEND-PLUS, the mean upper activity rate was 102 +/- 7 beats/min (range 90-120 beats/min), while the mean upper minute ventilation rate was 125 +/- 16 beats/min (range 100-150 beats/min). The mean rate responses during the exercise protocol and the final programming in minute ventilation and activity sensing modes were 5.4 +/- 2.3 (range 1-9), versus 4 +/- 2.4 (range 1-8; P < 0.01) and 7.6 +/- 1.1 (range 5-9), versus 7.5 +/- 0.8 (range 6-9; P = 0.8), respectively. In the combined sensing mode, the acceleration rate was identical to the activity rate response and the deceleration rate mimicked the minute ventilation.
  
  
  CONCLUSIONS
  Dual sensor VVIR pacemakers have the potential to improve rate adaptation to exercise. The rate response to exercise in patients fitted with activity and minute ventilation sensors, VVIR pacemakers closely mimics the physiological rate response.
authors.affiliation: Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Ovsyshcher
authors.forename: M
authors.initials: M
authors.lastname: Guldal
authors.forename: R
authors.initials: R
authors.lastname: Karaoguz
authors.forename: A
authors.initials: A
authors.lastname: Katz
authors.forename: C
authors.initials: C
authors.lastname: Bondy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015716:Electrocardiography, Ambulatory; D005069:Evaluation Studies as Topic; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D012119:Respiration