Cord blood transplantation in thalassemia.
Thalassemias and hemoglobinopathies are prevalent in Thailand. Bone marrow transplantation can cure thalassemia, but less than 30% of the patients have an HLA-identical sibling. Cord blood is an alternative source of stem cells for transplantation. By prenatal diagnosis, the fetus can be diagnosed as having thalassemic disease. DNA typing for HLA will be performed. Cord blood can be collected for transplantation if the fetus is not affected and is HLA-identical to the patient. We report a successful cord blood transplantation in a patient with beta-thalassemia/hemoglobin E disease.
Issaragrisil
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Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002678:Chimera; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D012150:Polymorphism, Restriction Fragment Length; D013785:Thailand / Q000453:epidemiology; D013789:Thalassemia / Q000150:complications / Q000453:epidemiology / Q000628:therapy*
D007166:Immunosuppressive Agents; D006446:Hemoglobin E