Studies of the ability of rhamnetin and isorhamnetin to alkylate bacterial DNA.
The alkylation of bacterial DNA by two flavonoids: rhamnetin and isorhamnetin was examined using of strains Escherichia coli K-12: AB1157 (ada+) and (ada3). Rhamnetin and isorhamnetin and their putative metabolites formed in the presence of the S9 mix did not alkylate DNA at 0-6 of guanine.
Czeczot
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Department of Biochemistry, Medical School, Warszawa.
D000478:Alkylation; D001711:Biotransformation; D004269:DNA, Bacterial / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D044948:Flavonols; D006147:Guanine / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D013014:SOS Response, Genetics / Q000187:drug effects
D004269:DNA, Bacterial; D044948:Flavonols; D009153:Mutagens; C047368:3-methylquercetin; D006147:Guanine; C063423:rhamnetin; D011794:Quercetin