Cell death (apoptosis) in cell culture systems.
In this review we describe the process of cell death known as apoptosis, outlining the key morphological and biochemical features. We also identify the stress elements in bioreactors that drive cells to their death. Finally, we outline methods that might be used to enhance the life span and increase the robustness of cells in culture.
Cotter
T G
TG
Department of Biochemistry, University College, Cork, Ireland.
al-Rubeai
M
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002478:Cells, Cultured / Q000502:physiology*