[Severe methemoglobinemia following large dose of nitrate medication].
A 49-year-old man with ischemic heart disease attempted to commit suicide by ingesting 300 tablets (6 grams) of isosorbide dinitrate. He was admitted with shortness of breath and cyanosis. Severe methemoglobinemia was diagnosed (blood level 47 mg%). After administration of intravenous methylene blue and fluids, there was immediate improvement and he was discharged 48 hours after admission.
Cafri
C
C
Division of Cardiology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheba.
Ilia
R
R
D005440:Fluid Therapy; D006801:Humans; D007548:Isosorbide Dinitrate / Q000009:adverse effects*; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000628:therapy; D008751:Methylene Blue / Q000627:therapeutic use; D008875:Middle Aged; D013406:Suicide, Attempted
D007548:Isosorbide Dinitrate; D008751:Methylene Blue