The retinoblastoma tumor suppressor protein.
Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/effectors of pRb have been identified recently, and the system of kinases that inactivate pRb is proving to be complex.
Hinds
P W
PW
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
D000818:Animals; D017353:Gene Deletion; D016161:Genes, Retinoblastoma; D006801:Humans; D016160:Retinoblastoma Protein / Q000235:genetics / Q000502:physiology*
D016160:Retinoblastoma Protein