Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.
Wetzel
J M
JM
Department of Chemistry, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA.
Miao
S W
SW
Forray
C
C
Borden
L A
LA
Branchek
T A
TA
Gluchowski
C
C
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000737:chemistry*; D002460:Cell Line; D003001:Cloning, Molecular; D004095:Dihydropyridines / Q000737:chemistry*; D006801:Humans; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D018340:Receptors, Adrenergic, alpha-1; C054074:niguldipine