Refined localization of human peroxisomal 3-oxoacyl-CoA thiolase (ACAA) to 3p22.
The chromosomal localisation of the human gene coding for peroxisomal 3-oxoacyl-CoA thiolase (ACAA) was determined by human-hamster somatic cell hybrids and fluorescence in situ hybridisation, using cDNA and genomic probes, respectively. The results allowed an exclusion of the previously suggested presence of a second site for ACAA on chromosome 11 and an assignment of the gene to a single chromosome band (3p22).
Ottone
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Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Italia.
Raimondi
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Rocchi
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Giussani
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F
Malcovati
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M
Tenchini
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ML
D000102:Acetyl-CoA C-Acyltransferase / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D002893:Chromosomes, Human, Pair 3; D006224:Cricetinae; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008830:Microbodies / Q000201:enzymology*
D015342:DNA Probes; D000102:Acetyl-CoA C-Acyltransferase