Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables.
Sixty-six patients with prostatic adenocarcinoma were screened for somatic instability at 8 microsatellite marker loci on 5 chromosomes. Differences in unrelated microsatellites for tumor and normal DNA were detected in 13 (19.7%) patients. Only extraglandular spread (nodal involvement and distant metastasis) was found to show significant association with somatic instability after controlling for other clinicopathological variables (P < 0.05). Microsatellite instability may possibly occur during the early stages of neoplastic transformation in a subset of prostate cancer rather than as a late event. This may be related to a phenotype with growth advantage. The frequency of this mutator phenotype is much higher in the United States than Japan, reflecting racial differences in the molecular tumorigenesis of this malignancy.
Egawa
S
S
Department of Urology, Kitasato University School of Medicine, Kanagawa, Japan.
Uchida
T
T
Suyama
K
K
Wang
C
C
Ohori
M
M
Irie
S
S
Iwamura
M
M
Koshiba
K
K
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics*; D004276:DNA, Satellite / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D008297:Male; D009154:Mutation; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012091:Repetitive Sequences, Nucleic Acid
D004273:DNA, Neoplasm; D004276:DNA, Satellite