Strategies for prenatal HLA typing for potential cord blood donor evaluation.
The reasons for prenatal HLA typing for potential cord blood stem cell donor evaluation are reviewed and the strategies for doing so are summarized. Cultured fetal cells are class I HLA typed by modified serological techniques. When indicated, the fetal cells are also class II HLA typed by one or another DNA typing method. The same procedures can be used for the prenatal identification of a potential donor for an affected fetus.
Pollack
M S
MS
Methodist Hospital, Histocompatibility and Clinical Immunology Laboratory, Houston, Texas 77030, USA.
Grant
G J
GJ
D001782:Blood Donors; D002478:Cells, Cultured; D005260:Female; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis; D006680:HLA Antigens / Q000032:analysis; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011296:Prenatal Diagnosis; D009927:Tissue and Organ Procurement
D006680:HLA Antigens