L-5178-Y lymphoma associated immunosuppression in Balb/c mice.
Lymphoma L-5178-Y bearing Balb/c mice were unable to mount a delayed-type hypersensitivity reaction to dinitrofluorobenzene (DNFB). A suppressor factor present in the ascitis of these mice inhibited the response if given during DNFB sensitization, but not during challenge. The factor was not present in lymphoma-bearing Balb/c nu/nu mice. It appeared to be a 35-66 kDa protein. Non-specific esterase staining indicated that the spleens of tumor-bearing and ascitis-injected mice contained a large excess of macrophages. Our observation that the suppressor factor prevented the very start of the immune response may indicate why immunostimulation is difficult to obtain in cancer bearing hosts.
Daneri-Navarro
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A
Instituto de Patologica Infecciosa Y Experimental "DR Francisco Ruiz Sanchez", Universidad de Guadalajara, Jalisco.
Del Toro-Arreola
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A
Garcia-Velazco
J C
JC
Del Toro-Arreola
S
S
Orbach-Arbouys
S
S
Bravo-Cuellar
A
A
D000818:Animals; D001201:Ascites / Q000276:immunology; D004139:Dinitrofluorobenzene / Q000494:pharmacology; D004342:Drug Hypersensitivity / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D016867:Immunocompromised Host; D008223:Lymphoma / Q000097:blood / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000276:immunology
D013491:Suppressor Factors, Immunologic; D004139:Dinitrofluorobenzene