[Clinical experience with alpha blockers and calcium antagonists in the perioperative treatment of pheochromocytoma].
This study aims to value the efficacy of the association between alpha-blockers and calcium channel-blockers, administered per os, in the reduction of preoperative preparation in patients with phaeochromocytoma and the calcium channel-blockers utility when are administered e.v. in the control of development of arterial paroxysmal hypertension during surgical manipulations. The trial had been conducted on 5 patients which have undergone the operation, before the operation we administered per os nifedipine and phonoxybenzamine for 8 days and during the operation we administered diltiazem e.v. The association between alpha-blockers and calcium-blockers per os, has reduced the preparation stage and has controlled the pressure parameters during the preoperative treatment. When we utilized diltiazem during the operation, we haven't note a good hemodynamic stability; these results are opposed to Tokioka's. Calcium channel-blockers and alpha-blockers seem to be a good therapy in the preoperative preparation of patients with phaeochromocytomas and they seem to be able to take fastly the standard of preoperative preparation.
Furino
A
A
Servizio di Anestesia e Rianimazione, Ospedale Consorziale, Policlinico, Bari.
Massagli
C
C
Pesce
C V
CV
Vulpis
V
V
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000601:surgery*; D000328:Adult; D000368:Aged; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D010673:Pheochromocytoma / Q000150:complications / Q000601:surgery*; D011300:Preoperative Care
D010643:Phenoxybenzamine; D009543:Nifedipine
Esperienza clinica con alpha-bloccanti e calcioantagonisti nel trattamento perioperatorio del feocromocitoma.