DCC: linking tumor suppressor genes and altered cell surface interactions in cancer?
The gene deleted in colorectal cancer (DCC) is a candidate tumor suppressor gene encoding a neural cell adhesion molecule like transmembrane protein. Over the past year, data supporting DCC inactivation in multiple tumor types have continued to accumulate. Functional studies suggest that DCC may participate in signaling pathways that regulate cell proliferation and/or differentiation, two cellular processes that often go awry during tumorigenesis.
Cho
K R
KR
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Fearon
E R
ER
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D002462:Cell Membrane / Q000378:metabolism; D016163:Genes, DCC; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology