[The action of gamma radiation at different dose rates on lipid peroxidation processes in mouse tissues].
The gamma-irradiation effect (the dose was 15 cGy; the dose rates were 0.01; 0.25 and 9 cGy/min) on the status of lipid peroxidation (LPO) regulatory system parameters in SHK mice (male) organs and blood 1, 7 and 32 days after radiation was studied. The greatest changes of LPO parameters in mice blood were revealed after low intensity radiation (0.01 cGy/min). The same direction in change of the initial concentration of peroxides in erythrocyte lipids and of the secondary (TBA-reactive) LPO products content in blood plasma for all dose rate was shown. The range of the changes of lipid antioxidant activity (AOA) in brain, liver and blood erythrocytes after mice irradiation (15 cGy) was found to be compared with the range of this parameter changes after high dose acute irradiation. The changes in the same direction of lipid AOA in liver and brain during the first week after 0.25 and 9 cGy/min dose rate irradiation and in blood erythrocytes and liver during the month after 0.25 cGy/min dose rate irradiation were established. The pro-oxidant activity and high initial concentrations of spleen lipids both in the control and especially in all experimental groups were revealed. The experimental data demonstrated the different sensitivity of LPO parameters to low dose radiation action depending on the dose rate, the changes of these parameters being kept for a long time after irradiation.
Poliakova
N V
NV
Shishkina
L N
LN
D000818:Animals; D000975:Antioxidants; D001769:Blood / Q000378:metabolism / Q000528:radiation effects; D001921:Brain / Q000378:metabolism / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors
D000975:Antioxidants
Vozdeĭstvie gamma-radiatsii raznoĭ moshchnosti na protsessy perekisnogo okisleniia lipidov v tkaniakh mysheĭ.