title: Formation of filamentous and multivesicular bodies after intrathecal MK-801 injection.
abstract: Our study of ultrastructural changes in lumbar spinal cord is based on the rats permanent intrathecal (IT) catheter model of MK-801 injection. After 3 days survival with the IT catheter the animals were treated by injection of MK-801 or saline. Five hrs post-treatment the rats were transcardially perfused with 4% paraformaldehyde in 0.1 M PB. L4-5 segments of the spinal cord were dissected and processed for EM. The presence of single or multiple filamentous/multivesicular bodies in neuronal cytoplasm of MK-801 treated animals was apparent.
authors.affiliation: Neurobiological Institute, Slovak Academy of Sciences.
authors.forename: J
authors.initials: J
authors.lastname: Orendácová
authors.forename: M
authors.initials: M
authors.lastname: Marsala
authors.forename: J
authors.initials: J
authors.lastname: Marsala
mesh_terms: D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D006056:Golgi Apparatus; D007278:Injections, Spinal; D016900:Neurofilament Proteins / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D016900:Neurofilament Proteins; D016291:Dizocilpine Maleate