Molecular recognition in DNA-binding proteins and enzymes.
The molecular basis for the specificity and activity of protein-DNA interactions is currently being established from the combination of results on the structure and biochemistry of DNA-binding proteins and enzymes. Data detailed in the 12 most recent studies on DNA-binding protein and enzyme structures, including the major advances in the elucidation of enzyme-mediated DNA-repair processes, have both increased understanding of DNA recognition and enhanced prospects for the design of novel DNA-binding proteins in the future.
Tainer
J A
JA
Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037.
Cunningham
R P
RP
D001709:Biotechnology; D004268:DNA-Binding Proteins / Q000737:chemistry*; D004798:Enzymes / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding; D011487:Protein Conformation
D004268:DNA-Binding Proteins; D004798:Enzymes