A new material with theoretical osteoinductive properties: experimental evaluation.
An intensive research for bone substitutes has been in progress for several decades in order to find a new ideal material for bone replacement. In the present study the Authors report some data on a new developed material in comparison with synthetic hydroxyapatite. The new material was characterised by means of a crystallographic spectroscopic and chemical study. An in vitro test was also performed using murine fibroblasts. The results of this preliminary study showed that the sintered material has an and beta-tricalcium-phosphate (TCP) lattice depending on thermal treatment in accordance with literature data. Moreover, it showed a high level of biocompatibility. Though it is still in an investigation stage, perhaps this biomaterial is a highly reactive and unstable compound that could interact with CO2 and H2O.
Giardino
R
R
Department of Experimental Surgery, Rizzoli Orthopaedic Institutes, Bologna.
Mongiorgi
R
R
Bertocchi
G
G
Fini
M
M
Giavaresi
G
G
Capelli
S
S
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D016723:Bone Remodeling / Q000187:drug effects; D002130:Calcium Phosphates / Q000737:chemistry; D002460:Cell Line; D018360:Crystallography, X-Ray; D017886:Durapatite / Q000737:chemistry; D005347:Fibroblasts / Q000187:drug effects; D006358:Hot Temperature; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D051379:Mice; D013055:Spectrophotometry, Infrared
D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; D007770:L-Lactate Dehydrogenase; C485829:calcium phosphate, dibasic, anhydrous