title: Uptake of dietary RRR-alpha- and RRR-gamma-tocopherol by nervous tissues, liver and muscle in vitamin-E-deficient rats.
abstract: The time course of RRR-alpha-tocopherol and RRR-gamma-tocopherol uptake by liver, muscle and selected nervous tissues was studied in vitamin-E-deficient rats fed diets containing either RRR-alpha-tocopherol or RRR-gamma-tocopherol over a 60 day period. Feeding rats with a RRR-alpha-tocopherol-supplemented diet induced in brain, cerebellum, sciatic endoneurium and muscle a marked and regular increase in alpha-tocopherol concentration. In addition, the tocopherol concentration in liver reached a plateau very rapidly. In contrast, feeding rats with a diet containing the same level of RRR-gamma-tocopherol induced a very small increase in gamma-tocopherol concentration in brain, cerebellum, sciatic endoneurium and muscle, no change in alpha-tocopherol concentration of brain and muscle and a slight but significant decrease in alpha-tocopherol concentration in sciatic endoneurium and cerebellum. These results indicate that when gamma-tocopherol was supplied continuously in the diet gamma-tocopherol accumulated significantly in the tissues but to a much lesser extent than when rats were fed with RRR-alpha-tocopherol. These results also show that in the tocopherol-deficient rat, gamma-tocopherol does not significantly affect the residual alpha-tocopherol concentrations in brain or cerebellum, except poorly in sciatic endoneurium.
authors.affiliation: INSERM U. 26 Hôpital Fernand Widal, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Clément
authors.forename: L
authors.initials: L
authors.lastname: Dinh
authors.forename: J M
authors.initials: JM
authors.lastname: Bourre
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004032:Diet; D005260:Female; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000378:metabolism*
chemical_list: D014810:Vitamin E