Isolation and characterization of the chicken c-sno gene.
We have cloned and analyzed the chicken c-sno (cellular ski novel) gene. The promoter region and all of the intron/exon boundaries have been sequenced. The gene is approx. 12-kb long and contains six exons, the first of which is noncoding. The amino-acid sequences encoded in this first coding exon of c-sno and c-ski are highly related; however, the remainder of these two genes appears to be unrelated. Although there is evidence that the transcripts of mammalian c-sno are alternatively spliced, there is no evidence that chicken c-sno is alternatively spliced. The promoter region has a high G + C content and contains neither a TATAA nor a CAAT box. Potential binding sites for the transcription factors SP1, AP1 and AP2, are present upstream from the transcription start point.
Givol
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ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, MD 21702-1201, USA.
Boyer
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Hughes
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D000818:Animals; D001483:Base Sequence; D002645:Chickens / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D005091:Exons / Q000235:genetics; D015698:Genomic Library; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes / Q000235:genetics*; D017422:Sequence Analysis, DNA
D004268:DNA-Binding Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; C486158:SKIL protein, Gallus gallus