title: High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders.
abstract: OBJECTIVE
  To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders.
  
  
  METHODS
  Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution.
  
  
  METHODS
  Academic tertiary center.
  
  
  METHODS
  A homogeneous group of women that consisted of intermediate responders examined in their initial attempt and who received differing amounts of gonadotropins were examined.
  
  
  METHODS
  All patients were stimulated using a combination of a GnRH-agonist and FSH and hMG and were allocated into two groups, based on the amount of gonadotropin administered initially (four or six ampules).
  
  
  METHODS
  Implantation and pregnancy (clinical and ongoing) rates were compared.
  
  
  RESULTS
  There were no significant differences between patients receiving high doses versus those patients receiving lower doses of gonadotropins with regard to implantation and pregnancy rates.
  
  
  CONCLUSIONS
  We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.
authors.affiliation: Department of Obstetrics and Gynecology, Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, USA.
authors.forename: T
authors.initials: T
authors.lastname: Simon
authors.forename: S
authors.initials: S
authors.lastname: Oehninger
authors.forename: J
authors.initials: J
authors.lastname: Toner
authors.forename: D
authors.initials: D
authors.lastname: Jones
authors.forename: S
authors.initials: S
authors.lastname: Muasher
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007246:Infertility / Q000628:therapy; D016729:Leuprolide / Q000627:therapeutic use; D008596:Menotropins / Q000008:administration & dosage* / Q000627:therapeutic use; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D008596:Menotropins; D005640:Follicle Stimulating Hormone; D016729:Leuprolide