title: [The protective effect of monoclonal anti-idiotypic antibodies in experimental herpes infection].
abstract: The protective effect of monoclonal anti-idiotypic antibodies m(anti-ID)Abs, simulating the biologic effects of human alpha interferons, were studied in male guinea pigs with genital herpes simplex. Therapeutic effect of m(anti-ID)Abs daily applied as liquid dosage form and as suppositories+ was assessed. Experiments demonstrated that m(anti-ID)Abs in liquid dosage form to a different measure decreased the severity of urogenital infection in guinea pigs and that m(anti-ID)Abs-25 completely prevented the development of grave infection.
authors.forename: F G
authors.initials: FG
authors.lastname: Nagieva
authors.forename: E P
authors.initials: EP
authors.lastname: Barkova
authors.forename: V G
authors.initials: VG
authors.lastname: Nikulina
authors.forename: N I
authors.initials: NI
authors.lastname: Krasnova
authors.forename: O G
authors.initials: OG
authors.lastname: Andzhaparidze
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002460:Cell Line; D002522:Chlorocebus aethiops; D006224:Cricetinae; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000517:prevention & control*; D007167:Immunotherapy; D008297:Male; D014709:Vero Cells
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal
vernacular_title: Protektivnyĭ éffekt monoklonal'nykh antiidiotipicheskikh antitel pri éksperimental'noĭ gerpeticheskoĭ infektsii.