title: Fibroblasts as efficient antigen-presenting cells in lymphoid organs.
abstract: Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
authors.affiliation: Institute of Experimental Immunology, University of Zürich, Switzerland.
authors.forename: T M
authors.initials: TM
authors.lastname: Kündig
authors.forename: M F
authors.initials: MF
authors.lastname: Bachmann
authors.forename: C
authors.initials: C
authors.lastname: DiPaolo
authors.forename: J J
authors.initials: JJ
authors.lastname: Simard
authors.forename: M
authors.initials: M
authors.lastname: Battegay
authors.forename: H
authors.initials: H
authors.lastname: Lother
authors.forename: A
authors.initials: A
authors.lastname: Gessner
authors.forename: K
authors.initials: K
authors.lastname: Kühlcke
authors.forename: P S
authors.initials: PS
authors.lastname: Ohashi
authors.forename: H
authors.initials: H
authors.lastname: Hengartner
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005347:Fibroblasts / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D007739:L Cells; D008216:Lymphocytic Choriomeningitis / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014162:Transfection; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D006023:Glycoproteins; D015395:Histocompatibility Antigens Class I; D014764:Viral Proteins