title: Expression of bcl-2 inhibits necrotic neural cell death.
abstract: Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis of neural cells induced by glutathione depletion. This finding demonstrates that bcl-2 does not inhibit the cellular death program directly; rather, bcl-2 modulates a cellular process that leads to apoptosis under some conditions but necrosis under others.
authors.affiliation: Department of Neurology, University of California at Los Angeles, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Kane
authors.forename: T
authors.initials: T
authors.lastname: Ord
authors.forename: R
authors.initials: R
authors.lastname: Anton
authors.forename: D E
authors.initials: DE
authors.lastname: Bredesen
mesh_terms: D000818:Animals; D017209:Apoptosis; D001312:Aurintricarboxylic Acid / Q000494:pharmacology; D016923:Cell Death / Q000235:genetics*; D002478:Cells, Cultured; D004247:DNA; D004586:Electrophoresis; D015870:Gene Expression / Q000235:genetics*; D005978:Glutathione; D008854:Microscopy, Electron; D009336:Necrosis / Q000235:genetics*
chemical_list: D001312:Aurintricarboxylic Acid; D004247:DNA; D005978:Glutathione