title: Seasonal rhythm of platelet [3H]imipramine binding in adolescents who attempted suicide.
abstract: OBJECTIVE
  This study was designed to determine the seasonality of serotonin functions among adolescents who attempt suicide.
  
  
  METHODS
  Platelet [3H]imipramine binding was assessed over a period of 18 months in 98 adolescents who attempted suicide and a comparison group of 23 never-suicidal youths with conduct disorder.
  
  
  RESULTS
  [3H]Imipramine (Bmax) was uncorrelated with age, but showed considerable seasonal variability over time in those who had attempted suicide.
  
  
  CONCLUSIONS
  [3H]Imipramine binding density in adolescents who attempted suicide exhibited significant seasonality, reaching a nadir in late winter/early spring.
authors.affiliation: Division of Child and Adolescent Psychiatry, College of Physicians and Surgeons of Columbia-Presbyterian Medical Center, New York, NY 10032, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Pine
authors.forename: P D
authors.initials: PD
authors.lastname: Trautman
authors.forename: D
authors.initials: D
authors.lastname: Shaffer
authors.forename: L
authors.initials: L
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Davies
authors.forename: M
authors.initials: M
authors.lastname: Stanley
authors.forename: B
authors.initials: B
authors.lastname: Parsons
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001792:Blood Platelets / Q000737:chemistry / Q000378:metabolism*; D002648:Child; D002653:Child Behavior Disorders / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D007099:Imipramine / Q000032:analysis / Q000378:metabolism*; D008297:Male; D012621:Seasons; D012701:Serotonin / Q000502:physiology; D013406:Suicide, Attempted / Q000706:statistics & numerical data*
chemical_list: D012701:Serotonin; D007099:Imipramine