The DXS423E gene in Xp11.21 escapes X chromosome inactivation.
The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.
Brown
C J
CJ
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Miller
A P
AP
Carrel
L
L
Rupert
J L
JL
Davies
K E
KE
Willard
H F
HF
D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002877:Chromosomes, Human; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D008297:Male; D008969:Molecular Sequence Data; D005810:Multigene Family; D016133:Polymerase Chain Reaction / Q000379:methods; D014158:Transcription, Genetic; D014960:X Chromosome / Q000235:genetics*
D018076:DNA, Complementary