Significance of anti-LU8 in pregnancy.
Anti-LU8, an antibody defining a high-frequency antigen in the Lutheran system, was identified in the serum of a gravida 4 para 0 pregnant women who had never been transfused. The antibody consisted of both an IgM and an IgG1 component and was nonreactive in the antibody-dependent cell-mediated cytotoxicity (ADCC) assay. The red cells of the mother and 3 siblings of the patient typed as LU:8,14 and were incompatible with the patient's serum. The baby was born at term with a negative direct antiglobulin test and typed as LU:8,14. There was no clinical evidence of haemolytic disease of the newborn.
Watt
J
J
State Red Cell Reference Laboratory, NSW Red Cross BTS, Syndey, Australia.
Jones
M L
ML
Rose
P
P
Pepper
R
R
D000328:Adult; D000911:Antibodies, Monoclonal; D004899:Erythroblastosis, Fetal / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008188:Lutheran Blood-Group System / Q000276:immunology*; D011247:Pregnancy / Q000097:blood*; D011250:Pregnancy Complications, Hematologic / Q000097:blood
D000911:Antibodies, Monoclonal; D008188:Lutheran Blood-Group System