title: Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication.
abstract: Interleukin-1 beta (IL-1 beta), a cytokine released by activated immune cells, elicits various illness symptoms including hyperthermia. Previous hypotheses to account for these actions have focused on blood-borne IL-1 beta exerting its effects directly at the level of the brain. However, recent behavioral and physiological evidence suggest that IL-1 beta can activate the subdiaphragmatic vagus. The present experiments demonstrate that subdiaphragmatic vagal transection disrupts the hyperthermia-inducing effects of recombinant human IL-1 beta and stress. These data provide evidence for a novel route of immune-brain communication, as well as a novel route whereby stress can influence physiological processes.
authors.affiliation: Department of Psychology, University of Colorado at Boulder 80309, USA.
authors.forename: L R
authors.initials: LR
authors.lastname: Watkins
authors.forename: L E
authors.initials: LE
authors.lastname: Goehler
authors.forename: J K
authors.initials: JK
authors.lastname: Relton
authors.forename: N
authors.initials: N
authors.lastname: Tartaglia
authors.forename: L
authors.initials: L
authors.lastname: Silbert
authors.forename: D
authors.initials: D
authors.lastname: Martin
authors.forename: S F
authors.initials: SF
authors.lastname: Maier
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology*; D005334:Fever; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological; D013997:Time Factors; D014628:Vagotomy
chemical_list: D007375:Interleukin-1