title: Signal transduction and growth control in yeast.
abstract: An understanding of how an extracellular stimulus causes changes in cell growth is emerging from the study of four signal transduction pathways in Saccharomyces cerevisiae: the pheromone-response, pseudohyphal differentiation, osmolarity-response, and protein kinase C activated pathways. Each of these pathways contains at its core a distinct mitogen-activated protein kinase cascade. Biochemical and molecular studies have determined the functional order of the kinases in the pheromone-response pathway and have suggested that they are organized into a complex by a protein scaffold. The cell surface sensor system for the osmolarity-response pathway has been identified. It shows striking similarity to bacterial two-component sensor-responder systems. Finally, components that integrate information from these pathways and communicate it to cell growth regulators have been revealed.
authors.affiliation: Institute of Molecular Biology, University of Oregon, Eugene 97403-1229, USA.
authors.forename: J
authors.initials: J
authors.lastname: Schultz
authors.forename: B
authors.initials: B
authors.lastname: Ferguson
authors.forename: G F
authors.initials: GF
authors.lastname: Sprague
mesh_terms: D005990:Glycerol / Q000378:metabolism; D009994:Osmolar Concentration; D010675:Pheromones / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D010675:Pheromones; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases; D005990:Glycerol