Immunohistochemical study of mammary and extramammary Paget's disease.
Immunophenotypes of mammary (MPD) and extramammary Paget's disease (EPD) are still not well understood. Thirty-four formalin-fixed paraffin-embedded tissue sections from 33 patients with 6 MPD and 28 EPD were studied immunohistochemically with the use of polyclonal c-erbB-2 and pS2 antisera, and monoclonal nm23, B6.2, GCDFP-15, and p53 antibodies. Cases of MPD expressed a high incidence of c-erbB-2 and nm23 compared with those of EPD (100% vs. 29%; p < 0.01, and 83% vs. 29%; p < 0.05, respectively). Although high expression of B6.2 (> 83%) and moderate expression of GCDFP-15 (33-39%), pS2 (33-46%) and p53 (39-50%) were seen, the positivity was not significantly different between MPD and EPD. These findings indicate that MPD and EPD share immunohistochemical features but partially differ in their patterns of antigen expression.
Nakamura
G
G
Department of Pathology, Kansai Medical University, Osaka, Japan.
Shikata
N
N
Shoji
T
T
Hatano
T
T
Hioki
K
K
Tsubura
A
A
D000951:Antigens, Neoplasm / Q000032:analysis; D001005:Anus Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D001053:Apolipoproteins; D053399:Apolipoproteins D; D001365:Axilla; D001943:Breast Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D002352:Carrier Proteins / Q000032:analysis; D005260:Female; D015870:Gene Expression; D005834:Genital Neoplasms, Male / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D006023:Glycoproteins; D006801:Humans; D008297:Male; D026901:Membrane Transport Proteins; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins / Q000032:analysis; D009701:Nucleoside-Diphosphate Kinase; D010145:Paget Disease, Extramammary / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D010144:Paget's Disease, Mammary / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D011506:Proteins; D012878:Skin Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D014157:Transcription Factors / Q000032:analysis; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology*
C024328:APOD protein, human; D000951:Antigens, Neoplasm; D001053:Apolipoproteins; D053399:Apolipoproteins D; D002352:Carrier Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins; C488892:PIP protein, human; D011506:Proteins; C051838:TFF1 protein, human; D014157:Transcription Factors; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins