Effect of galactosamine-induced hepatitis on the aerobic and anaerobic metabolism of the rat exposed to high-altitude hypoxia.
Galactosamine-induced hepatitis caused a marked increase in plasma lactate and pyruvate, but completely abolished the increase in ketone bodies in the rat exposed to an 8000 m simulated altitude. Plasma free fatty acid as the precursor of ketone bodies was higher in the galactosamine-treated rats during and after an exposure to 8000 m altitude. Treatment of the rat with galactosamine markedly reduced activities of citrate synthase, fumarase, glutamate dehydrogenase and fructose 1,6-bisphosphatase, but increased hexokinase and glucose 6-phosphate dehydrogenase in the liver. The effect of galactosamine-induced hepatitis on the energy metabolism can be explained by a reduction of mitochondrial oxidative enzymes and gluconeogenesis, and involves a shift of the aerobic metabolism to anaerobic glycolysis at high altitude.
Yamamoto
C
C
Department of Endocrinology and Metabolism, Nagoya University, Japan.
Mori
S
S
Murakami
K
K
Yoshino
M
M
D000332:Aerobiosis; D000531:Altitude; D000693:Anaerobiosis; D000818:Animals; D002950:Citrate (si)-Synthase / Q000378:metabolism; D004734:Energy Metabolism; D005227:Fatty Acids / Q000097:blood; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005649:Fumarate Hydratase / Q000378:metabolism; D005688:Galactosamine / Q000633:toxicity*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism; D007657:Ketone Bodies / Q000378:metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000201:enzymology; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D051381:Rats; D017207:Rats, Sprague-Dawley
D005227:Fatty Acids; D007657:Ketone Bodies; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D005688:Galactosamine; D019289:Pyruvic Acid; D005954:Glucosephosphate Dehydrogenase; D005969:Glutamate Dehydrogenase; D002950:Citrate (si)-Synthase; D006597:Fructose-Bisphosphatase; D005649:Fumarate Hydratase