title: Neurologic complications of Merkel cell carcinoma.
abstract: We describe a 61-year-old man with a multiple neurologic complication of Merkel cell carcinoma, a rare skin cancer. An enhancing brain mass, and cytologically proven leptomeningeal disease produced a succession of symptoms including seizures, bilateral radiculopathies, myoclonus, a cauda equina syndrome and altered mental status. Aggressive treatment prolonged his survival marginally.
authors.affiliation: Department of Neurology, University Hospitals of Cleveland/Case Western Reserve School of Medicine, Ohio, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Snodgrass
authors.forename: H
authors.initials: H
authors.lastname: Landy
authors.forename: A M
authors.initials: AM
authors.lastname: Markoe
authors.forename: L
authors.initials: L
authors.lastname: Feun
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000556:secondary*; D015266:Carcinoma, Merkel Cell / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology / Q000556:secondary*; D003561:Cytarabine / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000556:secondary*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology*; D012878:Skin Neoplasms / Q000473:pathology* / Q000503:physiopathology
chemical_list: D003561:Cytarabine; D002955:Leucovorin; D008727:Methotrexate