title: A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle.
abstract: Corticotropin-releasing factor (CRF) mediates many critical aspects of the physiological response to stress. These effects are elicited by binding to specific high-affinity receptors, which are coupled to guanine nucleotide stimulatory factor (Gs)-response pathways. Recently, a gene encoding a receptor for CRF, expressed in pituitary and the central nervous system (PC-CRF receptor), was isolated and characterized. Here we report the identification and characterization of a second, distinct CRF receptor that is expressed primarily in heart and skeletal muscle and exhibits a specific ligand preference and antagonist sensitivity compared with the PC-CRF receptor. We refer to this second receptor as the heart/muscle (HM)-CRF receptor.
authors.affiliation: Eukaryotic Regulatory Biology Program, University of California at San Diego, School of Medicine, La Jolla 92093-0648.
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
authors.forename: R V
authors.initials: RV
authors.lastname: Pearse
authors.forename: C R
authors.initials: CR
authors.lastname: Lin
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000595:Amino Acid Sequence; D029845:Amphibian Proteins; D000818:Animals; D003001:Cloning, Molecular; D018076:DNA, Complementary; D051379:Mice; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010452:Peptide Biosynthesis; D036361:Peptide Hormones; D010455:Peptides / Q000235:genetics; D018019:Receptors, Corticotropin-Releasing Hormone / Q000096:biosynthesis* / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D029845:Amphibian Proteins; D018076:DNA, Complementary; D036361:Peptide Hormones; D010455:Peptides; D018019:Receptors, Corticotropin-Releasing Hormone; C025727:sauvagine