Penicillin G extraction from model media using an emulsion liquid membrane: determination of optimum extraction conditions.
Penicillin G extraction by an emulsion liquid membrane (ELM) was investigated. The effects of surfactants, diluents, and carrier mixtures, together with their combined effects on the initial extraction rate and the emulsion stability were examined. Surfactants, diluents, and carriers used were Span80 (sorbitan monooleate)/ECA4360J (nonionic polyamine), n-butyl acetate/kerosene, and DOA (dioctylamine)/Amberlite LA-2 (secondary amine), respectively. The optimum extraction conditions were found to be 20% (v/v) of Span80 in ECA4360J as a surfactant, kerosene as a diluent and Amberlite LA-2 as a carrier.
Lee
K H
KH
Department of Chemical Engineering, Korea Advanced Institute of Science and Technology, Kusong Dong, Yusung Gu, Taejeon.
Lee
S C
SC
Lee
W K
WK
D001709:Biotechnology / Q000379:methods*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D007700:Kinetics; D008566:Membranes / Q000737:chemistry; D008956:Models, Chemical; D010400:Penicillin G / Q000737:chemistry / Q000302:isolation & purification*; D012997:Solvents; D013501:Surface-Active Agents / Q000737:chemistry
D004655:Emulsions; D012997:Solvents; D013501:Surface-Active Agents; D010400:Penicillin G