Gene targeting in mammalian cells by homologous recombination.
Gene targeting by homologous recombination is a genetic tool that permits modification of cellular genes in a precise and predetermined fashion. The methodologies that are currently available permit gene targeting at high efficiency and fidelity. New developments promise large-scale modification of the mammalian genome using these techniques.
Morrow
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B
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461.
Kucherlapati
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R
D000818:Animals; D001709:Biotechnology; D002460:Cell Line; D004274:DNA, Recombinant / Q000235:genetics; D005821:Genetic Techniques; D005822:Genetic Vectors; D051379:Mice; D016296:Mutagenesis; D011995:Recombination, Genetic; D013234:Stem Cells
D004274:DNA, Recombinant