title: [The analgesic action of new enkephalin analogs].
abstract: The enkephalin analogue peptide IKB-901 containing epsilon-ACA and cysteine with the modified S-end shows an analgetic activity in rats (1 micron, intrathecally and 5 mg/kg intravenously) and in cats (0.35 and 0.7 mg/kg intravenously). Naloxone (0.1 mg/kg) prevents the analgetic effect of peptide. The coadministration of the peptide and the enkephalinase inhibitor D-phenylalanine (0.35 and 10 mg/kg, respectively) enhances analgesia and displays an antihypertensive effect in nociceptive stimulation.
authors.forename: E V
authors.initials: EV
authors.lastname: Solov'eva
authors.forename: S V
authors.initials: SV
authors.lastname: Kulikov
authors.forename: A O
authors.initials: AO
authors.lastname: Khar'kovskiĭ
authors.forename: E G
authors.initials: EG
authors.lastname: Bogdanov
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004745:Enkephalins / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D010146:Pain / Q000188:drug therapy; D051381:Rats; D013997:Time Factors
chemical_list: D000700:Analgesics; D004745:Enkephalins
vernacular_title: O boleutoliaiushchem deĭstvii novykh analogov énkefalinov.