title: Symphytoxide A, a triterpenoid saponin from the roots of Symphytum officinale.
abstract: A new triterpenoidal saponin of hederagenin named symphytoxide A has been isolated from the ethanolic extract of the roots of Symphytum officinale and characterized on the basis of chemical investigations and spectroscopic studies as 3-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->4)- alpha-L-arabinopyranosyl] hederagenin. The structure of this new saponin was established on the basis of 1D and 2D NMR experiments including heteroCOSY, COSY-45 degrees as well as HMBC measurements and other spectroscopic techniques. The saponin exhibited hypotensive activity in anesthetized rats.
authors.affiliation: H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
authors.forename: V U
authors.initials: VU
authors.lastname: Ahmad
authors.forename: M
authors.initials: M
authors.lastname: Noorwala
authors.forename: F V
authors.initials: FV
authors.lastname: Mohammad
authors.forename: B
authors.initials: B
authors.lastname: Sener
authors.forename: A H
authors.initials: AH
authors.lastname: Gilani
authors.forename: K
authors.initials: K
authors.lastname: Aftab
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002240:Carbohydrate Sequence; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008969:Molecular Sequence Data; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D012503:Saponins; C080393:symphytoxide A; D009828:Oleanolic Acid