Antigen-induced conformational changes in antibodies: a problem for structural prediction and design.
Recent work has shown that large conformational changes in antibodies can accompany antigen binding. These structural changes can alter dramatically the size, shape and charge distribution in the antigen-binding pocket, and may present problems for accurate modeling of antibody structures.
Stanfield
R L
RL
Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037.
Wilson
I A
IA
D000818:Animals; D000906:Antibodies / Q000737:chemistry* / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation
D000906:Antibodies; D000941:Antigens