title: Bactericidal effect of rat cystatin S on an oral bacterium Porphyromonas gingivalis.
abstract: We tested antibacterial and antiviral activities of rat cystatin S, a cysteine proteinase inhibitor, belonging to the family 2 cystatins against 18 different bacterial species and poliovirus type 1 (Sabin). Rat cystatin S specifically inhibited the growth of a human oral anaerobic bacterium Porphyromonas gingivalis due to a bactericidal effect.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Umemoto
authors.forename: I
authors.initials: I
authors.lastname: Namikawa
authors.forename: K
authors.initials: K
authors.lastname: Sakae
authors.forename: Y
authors.initials: Y
authors.lastname: Ishihara
authors.forename: S
authors.initials: S
authors.lastname: Isomura
authors.forename: I
authors.initials: I
authors.lastname: Suzuki
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D015891:Cystatins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D017955:Poliovirus / Q000187:drug effects; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D021382:Protein Sorting Signals / Q000737:chemistry / Q000235:genetics; D051381:Rats; D055333:Salivary Cystatins; D013045:Species Specificity; D013297:Streptococcus pyogenes / Q000187:drug effects
chemical_list: C525173:CST4 protein, human; C525174:Cyss protein, rat; D015891:Cystatins; D015853:Cysteine Proteinase Inhibitors; D021382:Protein Sorting Signals; D055333:Salivary Cystatins