Formation of filamentous and multivesicular bodies after intrathecal MK-801 injection.
Our study of ultrastructural changes in lumbar spinal cord is based on the rats permanent intrathecal (IT) catheter model of MK-801 injection. After 3 days survival with the IT catheter the animals were treated by injection of MK-801 or saline. Five hrs post-treatment the rats were transcardially perfused with 4% paraformaldehyde in 0.1 M PB. L4-5 segments of the spinal cord were dissected and processed for EM. The presence of single or multiple filamentous/multivesicular bodies in neuronal cytoplasm of MK-801 treated animals was apparent.
Orendácová
J
J
Neurobiological Institute, Slovak Academy of Sciences.
Marsala
M
M
Marsala
J
J
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D006056:Golgi Apparatus; D007278:Injections, Spinal; D016900:Neurofilament Proteins / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects* / Q000648:ultrastructure
D016900:Neurofilament Proteins; D016291:Dizocilpine Maleate