Sweetness of glycyrrhetic acid 3-O-beta-D-monoglucuronide and the related glycosides.
To improve the taste profile of glycyrrhizin (1, the saponin of licorice root, relative sweetness to sucrose: x170), a variety of 3-O-glycosides of glycyrrhetic acid were prepared and their sweetness evaluated. It was found that a significant enhancement of sweetness was observed for the 3-O-beta-D-xyloside and the 3-O-beta-D-glucuronide (MGGR). Especially, MGGR had a high sweetness relative to sucrose; x941, and would appear to be a new potent sweetener.
Mizutani
K
K
Research Laboratories, Maruzen Pharmaceuticals Co., Ltd., Hiroshima, Japan.
Kuramoto
T
T
Tamura
Y
Y
Ohtake
N
N
Doi
S
S
Nakaura
M
M
Tanaka
O
O
D002240:Carbohydrate Sequence; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship; D013549:Sweetening Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*
D006027:Glycosides; D013549:Sweetening Agents; C052400:glycyrrhetyl 3-monoglucuronide; D006034:Glycyrrhetinic Acid