[Effects of captopril on platelet-derived growth factor ligand and receptor gene expression of vascular wall after balloon angioplasty].
A predominant fibromuscular plaque was produced by balloon catheter denuding angioplasty of both iliac arteries and feeding cholesterol in 16 New Zealand white rabbits. Balloon angioplasty was performed in model animals. Captopril-treated (n = 8, captopril 12.5 mg.kg-1/d) group which received captopril 7 days before to 4 wk after angioplasty were examined by dot blot hybridization. The results showed that captopril can inhibit platelet-derived growth factor ligand and receptor gene expression of vascular wall after balloon angioplasty.
Fang
N Y
NY
Department of Cardiology, Renji Hospital, Shanghai Second Medical University.
Zheng
D S
DS
Lu
H H
HH
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics / Q000378:metabolism*; D002216:Captopril / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis* / Q000235:genetics; D011817:Rabbits; D017479:Receptors, Platelet-Derived Growth Factor / Q000096:biosynthesis* / Q000235:genetics
D010982:Platelet-Derived Growth Factor; D002216:Captopril; D017479:Receptors, Platelet-Derived Growth Factor