Design of protein structures: helix bundles and beyond.
The design of proteins or peptides with novel functions can be achieved either by modifying existing molecules or by inventing entirely new structures and sequences that are unknown in nature. Combinatorial-design strategies have led to the first de novo proteins, but these still lack some of the desired attributes. The most promising practical strategies for developing proteins with useful biological or chemical function combine theoretical design with experimental screening or selection systems.
Sander
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European Molecular Biology Laboratory, Heidelberg, Germany.
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015202:Protein Engineering; D017510:Protein Folding; D017433:Protein Structure, Secondary