Gene amplifications in advanced-stage human prostate cancer.
Gene amplification is a model of proto-oncogene alterations occasionally observed in human tumors. This amplification can, in some cases, have prognostic value (N-myc in neuroblastoma, c-erbB2 and int-2 in breast cancer, etc.). Amplifications of the proto-oncogenes c-myc, c-erbB2 and int-2 have not yet been report in prostate adenocarcinoma, which, like breast cancer, is hormone dependent. We sought amplifications of these three proto-oncogenes by means of Southern blotting in 15 human prostate adenocarcinoma specimens, most of which were advanced (7 stage C and 6 stage D1 or D2). We confirmed the lack of c-myc and c-erbB2 amplification, regardless of the stage, in contrast to the case of breast cancer. Int-2 amplification was observed in one advanced tumor with bone metastases, out of a total of six stage D tumors. The precise frequency of int-2 amplification and its role in prostate carcinogenesis remain to be determined.
Fournier
G
G
Service d'Urologie, Hôpital Morvan, Brest, France.
Latil
A
A
Amet
Y
Y
Abalain
J H
JH
Volant
A
A
Mangin
P
P
Floch
H H
HH
Lidereau
R
R
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D000368:Aged; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors / Q000235:genetics; D005784:Gene Amplification; D018734:Genes, erbB-2; D016259:Genes, myc; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009857:Oncogenes; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics
C496444:FGF3 protein, human; D051518:Fibroblast Growth Factor 3; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors