title: Preparation of organic solvent-tolerant mutants from Pseudomonas aeruginosa strain PAO1161.
abstract: Most organic solvents (OSs) are toxic and inhibit growth of microorganisms even at low concentrations. Therefore, they are used to sterilize microbial cultures and to maintain solutions in a sterile condition. However, the physiological basis of such phenomenon is poorly understood. Although there are some microorganisms that can utilize a number of OSs as their sole carbon and energy sources, OSs must be provided as a vapor or at a very low concentration to avoid growth inhibition.
authors.affiliation: Deep Star Group, Japan Marine Science and Technology Center, Yokosuka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Komatsu
authors.forename: K
authors.initials: K
authors.lastname: Moriya
authors.forename: K
authors.initials: K
authors.lastname: Horikoshi
mesh_terms: D004361:Drug Tolerance; D006586:Hexanes / Q000633:toxicity*; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics*; D012997:Solvents; D014992:Xylenes / Q000633:toxicity*
chemical_list: D006586:Hexanes; D012997:Solvents; D014992:Xylenes; C026385:n-hexane; C031286:4-xylene