Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery.
Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT1-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC10-EC20) of prostaglandin F2 alpha (PGF2 alpha), angiotensin II (AII), histamine, norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT1-like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.
Yildiz
O
O
Department of Pharmacology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey.
Tuncer
M
M
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004357:Drug Synergism; D005260:Female; D006632:Histamine / Q000494:pharmacology; D007083:Iliac Artery / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology; D018170:Sumatriptan / Q000494:pharmacology*
D000804:Angiotensin II; D010656:Phenylephrine; D012701:Serotonin; D011189:Potassium Chloride; D006632:Histamine; D018170:Sumatriptan; D009638:Norepinephrine