ATP opens an electrophoretic potassium transport pathway in respiring yeast mitochondria.
In the presence of KCl and only at low phosphate concentrations, ATP stimulated state 4 of the respiration of isolated yeast mitochondria. This effect could be related to a partial collapse of the transmembrane potential which was created by the respiratory chain or the F0F1-ATPase. Sodium and lithium could not replace potassium ion. Atractyloside prevented the opening of this K+ pathway, suggesting that only matricial ATP operated. All these effects were inhibited by increasing phosphate concentration, or by adding propranolol, quinine, Zn2+ or Mg2+.
Roucou
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Institut de Biochimie et de Génétique Cellulaires, CNRS, Université de Bordeaux II, France.
Manon
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Guerin
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D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D017136:Ion Transport / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D010710:Phosphates / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology
D010710:Phosphates; D011189:Potassium Chloride; D000255:Adenosine Triphosphate; D011433:Propranolol; D011803:Quinine; D008274:Magnesium; D015032:Zinc; D011188:Potassium