title: Development of anti-Sm and anti-DNA antibodies followed by clinical manifestation of systemic lupus erythematosus in an elderly woman with long-standing Sjögren's syndrome.
abstract: A 69-year-old Japanese women who had been followed up for 10 years as a primary Sjögren's syndrome, is reported. She suddenly developed serological and clinical characteristics of systemic lupus erythematosus (SLE): anti-Sm and anti-dsDNA antibodies followed by nephrotic syndrome and pancytopenia. This case suggests that the diagnosis of primary Sjögren's syndrome should be considered as tentative in certain cases and that the development of serological characteristics precede and are associated with the development of clinical symptoms of SLE.
authors.affiliation: Department of Internal Medicine, National Murayama Hospital, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Yamagata
authors.forename: F
authors.initials: F
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Ogasawara
authors.forename: T
authors.initials: T
authors.lastname: Tojo
authors.forename: M
authors.initials: M
authors.lastname: Akizuki
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D009404:Nephrotic Syndrome / Q000150:complications; D017411:Ribonucleoproteins, Small Nuclear / Q000276:immunology; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D055517:snRNP Core Proteins
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins; D004247:DNA