title: [Application of fragrances to treatments for depression].
abstract: High pressure stress was found to induce immunosuppression accompanied with the enhancement of motor activity in mice. Citrus fragrance restored stress-induced immunosuppression and induced calm behavior in mice. In the forced swimming test using rats, citrus fragrance reduced the total immobility time and potentiated the imipramine-induced reduction in total immobility time. The application of citrus fragrance to depressive patients made it possible to markedly reduce the doses of antidepressants needed for the treatment of patients.
authors.affiliation: Department of Psychiatry, Mie University School of Medicine, Tsu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Komori
authors.forename: R
authors.initials: R
authors.lastname: Fujiwara
authors.forename: M
authors.initials: M
authors.lastname: Tanida
authors.forename: J
authors.initials: J
authors.lastname: Nomura
mesh_terms: D000328:Adult; D000818:Animals; D002957:Citrus; D003863:Depression / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D015213:Neuroimmunomodulation; D009812:Odorants; D051381:Rats; D017207:Rats, Sprague-Dawley