title: Antibacterial peptides in insect vectors of tropical parasitic disease.
abstract: The induction and characterization of immune peptides in two groups of medically important insects, the mosquitoes and blackflies, is currently an important research area. Mosquitoes transmit a variety of viral and parasitic diseases including yellow fever, dengue, malaria and lymphatic filariasis. Simuliid black flies are vectors of river blindness. The diseases are together responsible for death and morbidity in millions of people each year. The relationship between inducible peptides and bacterial and parasitic infections in these insects is proving to be a complex one. The identification of an insect defensin (4 kDa) in Aedes aegypti, the yellow fever mosquito, has proved to be the first peptide characterized in a vector of human disease. This inducible molecule appears in the haemolymph in response to bacterial and to a lesser extent filarial infection. The characterization of inducible blackfly peptides has revealed potent inducible anti-Gram-positive as well as anti-Gram-negative activity. In addition, non-self recognition molecules such as phenoloxidase may play a part in differentiating one species of eukaryotic pathogen from another of the same genus. The interactions between the peptides and these other proteins are likely to be important in the establishment of a successful immune response against a parasitic pathogen, particularly as we now know these peptides to have anti-eukaryotic activity (against a range of parasite species). As well as being of fundamental interest in our understanding of host-parasite relationships, the indication that antibacterial peptides are toxic to parasitic organisms has implications for their possible use in the disease vector control strategies of the future. It may also mean that a revision in our understanding of their mode of action, loose as it is, has to take place.
authors.affiliation: Centre for Applied Entomology and Parasitology, Keele University, Staffordshire, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Ham
authors.forename: C
authors.initials: C
authors.lastname: Albuquerque
authors.forename: B
authors.initials: B
authors.lastname: Smithies
authors.forename: R
authors.initials: R
authors.lastname: Chalk
authors.forename: S
authors.initials: S
authors.lastname: Klager
authors.forename: H
authors.initials: H
authors.lastname: Hagen
mesh_terms: D000330:Aedes / Q000276:immunology*; D000818:Animals; D000890:Anti-Infective Agents; D001798:Blood Proteins / Q000276:immunology; D023082:Defensins; D006801:Humans; D007303:Insect Vectors / Q000276:immunology*; D010272:Parasitic Diseases / Q000635:transmission*; D010455:Peptides / Q000276:immunology*; D012843:Simuliidae / Q000276:immunology*
chemical_list: D000890:Anti-Infective Agents; D001798:Blood Proteins; D023082:Defensins; D010455:Peptides