[Iminodimethylation, a method for pharmacomodulation in pyrimido-[3,4-a]-s-triazine series].
Primary amines react with two formaldehydes and compounds presenting two mobile hydrogen atoms, this reaction can be called iminodimethylation. This reaction can be used in order to perform a pharmacomodulation in the pyrimido [3,4-a]-s-triazine series. Against Epidermophyton floccosum, the activity is better when nitrogen 7 is not substituted, when the heroatom in position 2 is 0 instead of S and when an aromatic nucleus is directly linked to the nitrogen atom in position 3.
Menager
S
S
Laboratoire de Pharmacochimie et Biopharmacie, Faculté de Médecine et de Pharmacie de Rouen, Saint-Etienne-du-Rouvray.
Loire
C
C
Petrakian
T
T
Combet Farnoux
C
C
Delabos
C
C
Garnier
J
J
Lafont
O
O
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology; D014227:Triazines / Q000494:pharmacology
D000935:Antifungal Agents; D011743:Pyrimidines; D014227:Triazines
L'iminodiméthylation, une méthode de pharmacomodulation en série pyrimido [3,4-a]-s-triazinique.