Placental pathology: a neglected link between basic disease mechanisms and untoward pregnancy outcome.
The long-term goal of examining placentas from patients with adverse pregnancy outcomes has always been to understand better the basic underlying disease processes involved. Through a consideration of clinical, sonographic, laboratory, and anatomic pathological data this goal is now being realized. Placental pathology in the following four clinical scenarios is reviewed: preterm labor, intrauterine growth retardation, intrauterine fetal demise, and birth asphyxia with long-term adverse sequela.
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RW
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
D001238:Asphyxia Neonatorum / Q000209:etiology; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000209:etiology; D010922:Placenta Diseases / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome