title: Regeneration of unmyelinated peripheral axons in vitamin E-deficient rats.
abstract: Unmyelinated axons of normal and regenerated sciatic nerve were counted in controls and vitamin E-deficient rats. No significant change in the number of unmyelinated axons of uninjured nerve was found in the vitamin E deficiency in comparison to controls (12961 +/- 1591 and 12450 +/- 1290, respectively, mean +/- SEM). In regenerated nerve of control rats the number of unmyelinated axons was higher than in uninjured nerve (16971 +/- 1854 and 20786 +/- 1574 at 1 and 2 months after crush, respectively). In vitamin E-deficient rats the increase in number of unmyelinated axons was greater than in corresponding controls (21880 +/- 662) at 1 month after lesion, but the number returned to value found in uninjured nerve at 2 months after lesion (12536 +/- 659). These results suggest that sprouting at lesion may be enhanced but some regenerated axons does not survive at long term in vitamin E-deficiency.
authors.affiliation: Istituto di Scienze Morfologiche, Università di Urbino, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Cecchini
authors.forename: R
authors.initials: R
authors.lastname: Cuppini
authors.forename: S
authors.initials: S
authors.lastname: Ciaroni
authors.forename: L
authors.initials: L
authors.lastname: Guidi
authors.forename: P
authors.initials: P
authors.lastname: Ambrogini
authors.forename: P
authors.initials: P
authors.lastname: Del Grande
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D004032:Diet; D008297:Male; D008854:Microscopy, Electron; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000503:physiopathology* / Q000648:ultrastructure; D014811:Vitamin E Deficiency / Q000097:blood / Q000503:physiopathology*