Human decidua-associated protein hDP200 in menstrual fluid: comparison between fertile women and women after failed in-vitro fertilization/embryo transfer treatment.
The concentration of human decidua-associated protein (hDP) 200 was measured in 238 menstrual fluid samples obtained from normal fertile women and in 26 menstrual fluid samples obtained from infertile women who failed to conceive and menstruated following in-vitro fertilization (IVF)/embryo transfer treatment. A significant association was observed between the concentration of hDP200 and the age of the women. A maximal concentration of hDP200 was observed in women aged 28-30 years, with significantly lower concentrations in those aged 18-20 and 39-41 years. The presence of an intra-uterine device had no effect on menstrual fluid hDP200 concentrations. A significantly lower mean concentration of hDP200 (82 U/ml) was measured in menstrual fluid samples obtained from failed IVF/embryo transfer patients as compared with that in menstrual fluid samples from normal fertile women (191 U/ml). These findings support the concept that adequate endometrial function, as evaluated by menstrual fluid concentration of hDP200, is important for the success of the fertility process.
Halperin
R
R
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Tel-Aviv University, Israel.
Bracha
Y
Y
Schneider
D
D
Maymon
R
R
Kraicer
P F
PF
Hadas
E
E
D000293:Adolescent; D000328:Adult; D001826:Body Fluids / Q000378:metabolism*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007247:Infertility, Female / Q000378:metabolism*; D007434:Intrauterine Devices; D008598:Menstruation; D011257:Pregnancy Proteins / Q000378:metabolism*; D012016:Reference Values; D017211:Treatment Failure
D007136:Immunoglobulins; D011257:Pregnancy Proteins; C088113:decidua-associated protein 200