title: Effect of acute starvation on rat diaphragm function.
abstract: The effects of 130 h of acute starvation on diaphragm contractility fatigue were studied in isolated rat diaphragm strip preparations with phrenic nerve stimulation. Compared with controls, starvation produced a reduction in body and diaphragm weights. Twitch and tetanic tensions were reduced by starvation; however, when the force was calculated as the strength (normalized for the weight or muscle cross-section area of the diaphragm), no difference was observed between the control and experimental groups. Starvation induced a significant downward shift in the force-frequency relationship, and also increased diaphragm fatigability, but it had no effect on twitch contraction and relaxation time. We conclude that 130 h of acute starvation decreases diaphragmatic force and endurance, but the strength does not change, because of the reducing diaphragmatic mass.
authors.affiliation: Department of Physiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Gölgeli
authors.forename: C
authors.initials: C
authors.lastname: Ozesmi
authors.forename: C
authors.initials: C
authors.lastname: Süer
mesh_terms: D000818:Animals; D001835:Body Weight; D003964:Diaphragm / Q000033:anatomy & histology / Q000294:innervation / Q000503:physiopathology*; D004558:Electric Stimulation; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018763:Muscle Fatigue / Q000502:physiology*; D009126:Muscle Relaxation / Q000502:physiology; D009929:Organ Size; D010791:Phrenic Nerve / Q000502:physiology; D051381:Rats; D013217:Starvation / Q000503:physiopathology*