title: Evaluation of acidogenicity of commercial isomaltooligosaccharides mixture and its hydrogenated derivative by measurement of pH response under human dental plaque.
abstract: The acidogenicity of commercially available isomaltooligosaccharides mixture (IMO) and its hydrogenated derivative (IMO-H) were evaluated by the in vivo pH response under dental plaque of six subjects (aged 25-28) using intraoral apparatus. The apparatus, an indwelling pH sensor of a hydrogen ion-sensitive field effect transducer (ISFET), was placed on the buccal site of the mandibular first molar, and the plaque was accumulated for four days. The test sugars were applied with three methods-dropping the solution directly on the plaque, rinsing the oral cavity with the solution, and sucking a candy made of the test sugar (weight 3-4 g). IMO could not be evaluated as a type of sugar with low acidogenicity, especially by the candy method, but IMO-H could be evaluated as a type of sugar with very low acidogenicity in a similar manner as maltitol or sorbitol in all type of applications. The acidogenic response of dental plaque should be assumed to be closely related to salivary parameters such as the secretion rate or to mutans streptococci level of subjects and types of application.
authors.affiliation: Research and Development Center, Showa Sangyo Co., Ltd., Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Matsukubo
authors.forename: T
authors.initials: T
authors.lastname: Yatake
authors.forename: Y
authors.initials: Y
authors.lastname: Muramatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Takaesu
mesh_terms: D000328:Adult; D003731:Dental Caries / Q000517:prevention & control; D003773:Dental Plaque / Q000378:metabolism* / Q000382:microbiology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006865:Hydrogenation; D008297:Male; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology*; D012463:Saliva / Q000187:drug effects / Q000382:microbiology; D012472:Salivation / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D009844:Oligosaccharides