[Amiloride decreases heart susceptibility to "calcium paradox" after total ischemia].
It is shown that reperfusion of the postischemic heart by low-calcium solution and standard media was accompanied by a massive release of myoglobine, contracture development without cardiac contractions. Addition of amiloride (35 mmol/1) 5 min before ischemia and during low-calcium reperfusion prevents the heart damage after reintroduction of the standard-calcium media. We consider that high susceptibility of the postischemic heart to calcium paradox can be explained by activation of Na/H exchange and a decrease in the sodium gradient during low-calcium reperfusion. These findings confirm the so-called "intracellular sodium" hypothesis of the calcium paradox.
Alabovskiĭ
V V
VV
Vinokurov
A A
AA
D000584:Amiloride / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002118:Calcium / Q000494:pharmacology / Q000627:therapeutic use*; D066298:In Vitro Techniques; D017202:Myocardial Ischemia / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats
D000584:Amiloride; D002118:Calcium
Amilorid umenśhaet chuvstvitelńost serdtsa k "kaltsievomu paradoksu" posle totalńoĭ ishemii.