Clinical significance of cellular resistance in tumours to cytotoxic chemotherapy and radiotherapy.
Cellular resistance is a significant component of tumour treatment failure. More detailed understanding of resistance mechanisms has enabled us to plan circumvention strategies, though these are not yet in routine clinical use. Such resistance is, however, only one of several factors which render cure of advanced malignant disease difficult. It is important for researchers in this field to see not only therapeutic opportunities but also limitations of these approaches. It is hoped that increased cooperation between clinicians and scientists in the field of cellular resistance will yield further improvement in tumour response rates and cure.
Pomeroy
M
M
Blackrock Clinic, Co. Dublin, Ireland.
Moriarty
M
M
D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair; D004351:Drug Resistance; D015316:Genetic Therapy; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000532:radiotherapy* / Q000628:therapy; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006023:Glycoproteins