[Transforming Growth Factor Beta: structure, biologic effects and mechanism of action].
For more than a decade, Transforming Growth Factor Beta (TGF beta) has been intensively studied. Such studies have led to the identification of many related polypeptides which constitute the TGF beta family. These factors modulate many animal cell processes such as cell cycle progression, differentiation, adhesion, migration, extracellular matrix production, tissue development and repair processes. Recent studies have shown that TGF beta has also a cardioprotective effect and is implicated in inflammatory process. The mechanism by which cytokines of the TGF beta family initiate their many biological effects are not yet fully understood. However, the recent molecular cloning of various TGF beta receptor genes has provided many clues to address these questions. These findings have led to a proposition of an original and specific model for the mechanism of action of TGF beta.
Benzakour
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Thrombosis Research Institute, Molecular Genetics Department, London, Royaume-Uni.
D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D018125:Receptors, Transforming Growth Factor beta / Q000737:chemistry / Q000145:classification / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology
D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta
Transforming Growth Factor Beta: structure, effets biologiques et mécanismes d'action.