Vasoconstriction of isolated arteries induced by angiographic contrast media. A comparison of ionic and non-ionic contrast media iso-osmolar with plasma.
Angiographic contrast media (CM) may cause both vasodilatation and vasoconstriction, effects that can only be partly be explained by the media's hyperosmolality. The present study describes a CM-induced vasoconstriction of isolated rabbit coronary arteries that depends on chemotoxicity and ion content of the CM. Rings of arteries were mounted in tissue baths and the constrictions induced by different CM were measured. Iotrolan and iodixanol (non-ionic dimers) caused the most powerful constrictions followed by iohexol (non-ionic monomer) and mannitol. Ioxaglate (ionic dimer) and diatrizoate (ionic monomer) caused no or weak constrictions. By comparing these findings with previous studies, it is concluded that non-ionic media cause vasoconstriction due to depolarization of the smooth muscle cells, an effect that for iohexol can be counteracted by addition of 30 mM NaCl. The ionic media seem to cause hyperpolarization of the cells. This difference between non-ionic and ionic CM might be one of the reasons for the lower tendency of non-ionic CM to cause vasodilatation clinically.
Karstoft
J
J
Department of Diagnostic Radiology, University Hospital, Malmö, Sweden.
Bååth
L
L
Jansen
I
I
Edvinsson
L
L
D000792:Angiography; D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects*; D003973:Diatrizoate / Q000737:chemistry / Q000494:pharmacology; D007472:Iohexol / Q000737:chemistry / Q000494:pharmacology; D007477:Ions; D007485:Ioxaglic Acid / Q000737:chemistry / Q000494:pharmacology; D008353:Mannitol / Q000737:chemistry / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009994:Osmolar Concentration; D010949:Plasma; D011817:Rabbits; D012965:Sodium Chloride / Q000494:pharmacology; D014283:Triiodobenzoic Acids / Q000737:chemistry / Q000494:pharmacology; D014661:Vasoconstriction; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014664:Vasodilation
D003287:Contrast Media; D007477:Ions; D014283:Triiodobenzoic Acids; D014662:Vasoconstrictor Agents; D003973:Diatrizoate; C033300:iotrolan; D008353:Mannitol; D007472:Iohexol; D012965:Sodium Chloride; C044834:iodixanol; D007485:Ioxaglic Acid