Variability of beta-amyloid protein deposited lesions in Down's syndrome brains.
An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.
Ikeda
S
S
Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
Tokuda
T
T
Yanagisawa
N
N
Kametani
F
F
Ohshima
T
T
Allsop
D
D
D000328:Adult; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000032:analysis* / Q000276:immunology* / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D016657:Cerebral Amyloid Angiopathy / Q000209:etiology / Q000378:metabolism*; D004314:Down Syndrome / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D016501:Neurites / Q000737:chemistry; D016874:Neurofibrillary Tangles / Q000737:chemistry; D010446:Peptide Fragments / Q000276:immunology*; D012326:RNA Splicing; D016875:tau Proteins / Q000032:analysis* / Q000276:immunology / Q000378:metabolism
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; C093597:amyloid beta-protein precursor 695 (18-38); C093598:amyloid beta-protein precursor 695 (681-695); C093599:amyloid beta-protein precursor 770 (681-695); D016875:tau Proteins