title: [An unusual case of subacute sclerosing panencephalitis].
abstract: A 25-year-old man was admitted following deterioration in behavior and onset of blindness. He soon became comatose and died 6 weeks later. Brain biopsy showed nuclear inclusion bodies resembling viral capsids, astrocytosis and perivascular lymphocytic cuffing but no demyelination. The diagnosis of subacute sclerosing panencephalitis was made on finding: measles virus antigens in both serum and cerebrospinal fluid, the identification of measles RNA sequences in brain tissue by the polymerase chain reaction, and intense, oligoclonal, IgG-banding in the CSF. However, the relatively advanced age of the patient, the absence of myoclonus and the nondistinctive EEG profile lacking synchronous bursts of high-voltage slow and sharp waves, are unusual.
authors.affiliation: Dept. of Neurology, Chaim Sheba Medical Center, Tel Hashomer.
authors.forename: B A
authors.initials: BA
authors.lastname: Sela
authors.forename: S
authors.initials: S
authors.lastname: Hassin-Baer
authors.forename: Y
authors.initials: Y
authors.lastname: Goldhamer
authors.forename: S
authors.initials: S
authors.lastname: Polak-Charcon
authors.forename: D
authors.initials: D
authors.lastname: Nass
authors.forename: P
authors.initials: P
authors.lastname: Duvdevani
authors.forename: L
authors.initials: L
authors.lastname: Shulman
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008459:Measles virus / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis
chemical_list: D000956:Antigens, Viral