[Comparison of antitumor activity of tumor draining lymph node lymphocytes and peripheral blood lymphocytes in human oral cancer].
The in vitro and in vivo antitumor activity between DNL and autologous LAK cells was compared. The results showed that DNL cells activated in vitro by rIL-2 exhibited higher cytotoxicity to Tca 8113 cells than the same patient's LAK cells (75% and 36%, respectively). According to Winn's method, the inhibition rates of subcutaneously transplanted Tca cells in mice were 74% and 42% respectively. There was significantly difference in the antitumor activity in vitro and in vivo between two groups (P < 0.05), indicating that DNL cells which are more available are more practicable for adoptive immunotherapy.
Guo
W
W
School of Stomatology, Shanghai Second Medical University.
Qiu
W L
WL
He
R G
RG
D000328:Adult; D000368:Aged; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D008198:Lymph Nodes / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014062:Tongue Neoplasms / Q000473:pathology / Q000628:therapy*; D014407:Tumor Cells, Cultured