Magnetic resonance spectroscopy and its application to aging and Alzheimer's disease.
This is a review of magnetic resonance (MR) spectroscopy and its application to aging and Alzheimer's disease (AD). Examinations of perchloric acid extracts of AD brain tissue by MR spectroscopy reveal elevated levels of phosphomonoesters, phosphodiesters, and glutamate accompanied by reduced levels of N-acetyl-L-aspartate compared with extracts from controls. These metabolicalterations may be an indication of accelerated membrane phospholipid metabolism, glutamate neurotoxicity, and neuronal loss in AD brain that is not seen in normal aging. In vivo 31P MR spectroscopy studies of AD indicate that levels of phosphomonoesters are elevated early in the course of AD, which may be a causative molecular neuropathologic event. In vivo MR spectroscopy is a powerful technique to investigate the molecular neuropathology of the disease, to follow the progression of AD, and to assess the efficacy of experimental therapies.
McClure
R J
RJ
Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA.
Kanfer
J N
JN
Panchalingam
K
K
Klunk
W E
WE
Pettegrew
J W
JW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002648:Child; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008875:Middle Aged; D010755:Organophosphates / Q000378:metabolism; D010472:Perchlorates; D051381:Rats; D011916:Rats, Inbred F344
D010755:Organophosphates; D010472:Perchlorates