Successful treatment of a 93-year-old patient with hypoplastic acute monocytic leukemia using macrophage colony-stimulating factor.
A 93-year-old patient with hypoplastic acute monocytic leukemia (AMoL) achieved a complete remission after macrophage colony-stimulating factor (M-CSF) therapy. Initially, the patient was treated with a low dose of cytarabine, but this treatment proved ineffective. M-CSF was administered for 14 days by drip intravenous infusion, 800 x 10(4) units per day. After a gradual decrease in the number of leukemic cells, a rapid increase in neutrophils was observed in the peripheral blood, and a bone marrow examination 22 days after discontinuation of M-CSF medication revealed a complete remission. These findings suggest that M-CSF may be useful in treating some elderly patients who have hypoplastic AMoL.
Watanabe
A
A
Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.
Kawachi
Y
Y
Sakamoto
Y
Y
Ishikawa
K
K
Nishihara
T
T
Uchida
T
T
Mori
M
M
Setsu
K
K
Indo
N
N
D000368:Aged; D000369:Aged, 80 and over; D003561:Cytarabine / Q000627:therapeutic use; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000473:pathology / Q000628:therapy*; D016173:Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D008297:Male; D012074:Remission Induction
D003561:Cytarabine; D016173:Macrophage Colony-Stimulating Factor