Defective killing of Candida albicans hyphae by neutrophils from beige mice.
The candidacidal activity of neutrophils from BALB/c, C.B-17 +/+, C.B-17 scid/scid, scid/scid-bg/bg, C57BL/6 bg/+, C57BL/6 bg/bg, NIH III bg/bg-nu/+, and bg/bg-nu/nu mice was assessed. Killing of blastoconidia was moderately deficient with neutrophils from 2 strains of homozygous beige mice; however, neutrophils from all homozygous beige strains had a significantly decreased capacity to kill Candida albicans hyphae. This is the first demonstration of a decreased capacity of beige mouse neutrophils to kill C. albicans hyphae. The latter defect could be related to the enhanced susceptibility of beige mice to candidiasis.
Jones-Carson
J
J
Department of Surgery, University of Wisconsin Medical School, Madison 53706-1532, USA.
Vazquez-Torres
A
A
Balish
E
E
D000818:Animals; D002176:Candida albicans / Q000276:immunology*; D002469:Cell Separation; D005434:Flow Cytometry; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009504:Neutrophils / Q000276:immunology*