title: Ferritin immunohistochemical study on pontine nuclei from infants with pontosubicular neuron necrosis.
abstract: Immunohistochemical ferritin staining was performed on pontine nuclei of the brains of 17 infants with pontosubicular neuron necrosis (PSN), aged 23 to 42 weeks of gestation. Ferritin-positive cells were increased in cases of karyorrhexis with spongy changes and gliosis, but not in those of selective karyorrhexis. Ferritin-positive cells were more increased in the cases with extensive karyorrhectic neurons. Iron may be released to the damaged pontine tissue as a catalyst and microglia may play an important role in the repair of the tissue.
authors.affiliation: Department of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ozawa
authors.forename: A
authors.initials: A
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Mito
authors.forename: S
authors.initials: S
authors.lastname: Takashima
mesh_terms: D001253:Astrocytes / Q000737:chemistry; D005293:Ferritins / Q000032:analysis*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D017628:Microglia / Q000737:chemistry; D009336:Necrosis; D009474:Neurons / Q000737:chemistry* / Q000473:pathology; D009836:Oligodendroglia / Q000737:chemistry; D011149:Pons / Q000737:chemistry* / Q000473:pathology*; D012276:Ricin
chemical_list: D005904:Glial Fibrillary Acidic Protein; D005293:Ferritins; D012276:Ricin