title: A liquid-liquid blood-gas exchange for the treatment of acute respiratory failure. A new blood gas exchange using artificial blood as an oxygen carrier.
abstract: A new liquid-liquid blood gas exchange system was investigated using a venovenous low flow extracorporeal circuit. A 2 m2 hollow fiber dialyzer served as the interface of the blood and oxygen carrier (a 38 percent FC-43, perfluorocarbon emulsion in a buffered electrolyte solution), which was continuously recycled through a bubble oxygenator. Experiments were performed on five mongrel dogs under general anesthesia. Upon the arrest of spontaneous ventilation, the dogs' lungs were inflated with 50% oxygen gas under a positive pressure of 10 cmH2O. After 10 min of apnea the dogs' PaO2 decreased to 37 +/- 14 mmHg, and the extracorporeal circulation was started at 10 ml/min/kg b./w. At 15 min the PaO2 had risen to 80 +/- 41 mmHg and at 30 min to 121 +/- 17 mmHg. The oxygen transfer was 8.3 +/- 2.3 ml/min. The extracorporeal circulation was continued 5h, when PaO2 reached 156 +/- 90 mmHg, and PaCO2 148 +/- 43 mmHg, then stopped. Fifteen minutes later, the PaO2 had returned to 32 +/- 10 mmHg. These findings indicate that our blood gas exchange system can supply a sufficient amount of oxygen to the body under apnea with continuous positive airway pressure.
authors.affiliation: Chest Disease Research Institute, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mizuno
authors.forename: J
authors.initials: J
authors.lastname: Isobe
authors.forename: S
authors.initials: S
authors.lastname: Matsunobe
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Hitomi
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000302:isolation & purification*; D001784:Blood Gas Analysis; D001802:Blood Substitutes / Q000592:standards; D002245:Carbon Dioxide / Q000097:blood* / Q000302:isolation & purification; D002417:Cattle; D004285:Dogs; D004573:Electrolytes; D005112:Extracorporeal Circulation / Q000379:methods; D005466:Fluorocarbons / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D010313:Partial Pressure; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000628:therapy*
chemical_list: D001639:Bicarbonates; D001802:Blood Substitutes; D004573:Electrolytes; D005466:Fluorocarbons; D002245:Carbon Dioxide; D010100:Oxygen