title: History of diaphragm physiology: the achievements of Galen.
abstract: Galen (129-200 AD) produced a large written output which was to remain one of the major basis of clinical medicine for centuries. His contribution to respiration, reported in his own books and in those of Oribasius, was that of a chest physician and of an experimental physiologist. He described in minute details how to perform a remarkable series of experiments by which he demonstrated the anatomy and function of the respiratory muscles. He described the actions of the diaphragm and how it moves the rib cage, in a series of spinal chord sections and muscle denervations. He investigated the passive or active nature of expiration and made fine observations of lung movements through the exposed pleural space. He described the interaction between the lungs and chest wall and developed the concept of interaction between ribcage and abdominal muscles in maintaining the position of the diaphragm, showing a clear understanding of the principle that the diaphragm can move upward during an isovolume manoeuvre as long as the ribcage is allowed to expand. A skillful clinician, Galen applied his theories of the analysis of problems at the bedside, particularly in patients affected with dyspnoea which he attributed to respiratory muscle dysfunction.
authors.affiliation: Service de Pneumologie, Hôpital de la Pitié-Salpétrière, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Derenne
authors.forename: A
authors.initials: A
authors.lastname: Debru
authors.forename: A E
authors.initials: AE
authors.lastname: Grassino
authors.forename: W A
authors.initials: WA
authors.lastname: Whitelaw
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000502:physiology*; D000076145:Greece, Ancient; D049690:History, Ancient; D006801:Humans; D012119:Respiration