Inducible gene expression systems for higher eukaryotic cells.
Of the wide variety of regulatory systems that have been developed to control gene expression in higher eukaryotes, those utilizing elements from prokaryotic systems presently achieve the highest specificity. In particular, systems based on the repressor/operator elements of an Escherichia coli tetracycline resistance operon appear broadly applicable. During the past year, the usefulness of these systems has been demonstrated not only at the cellular level, but also at the organismal level (i.e. in transgenic animals and plants).
Gossen
M
M
Zentrum für Molekulare Biologie, Universität Heidelberg, Germany.
Bonin
A L
AL
Freundlieb
S
S
Bujard
H
H
D000818:Animals; D030801:Animals, Genetically Modified; D004926:Escherichia coli / Q000235:genetics; D005057:Eukaryotic Cells; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D009876:Operon; D030821:Plants, Genetically Modified; D013753:Tetracycline Resistance / Q000235:genetics; D014158:Transcription, Genetic