title: Double-blind, placebo-controlled trial of methylphenidate in older, depressed, medically ill patients.
abstract: OBJECTIVE
  The authors examined the efficacy of methylphenidate in the treatment of depression in a group of older, medically ill patients.
  
  
  METHODS
  Sixteen patients underwent an 8-day double-blind, randomized, placebo-controlled crossover trial; 13 completed the trial.
  
  
  RESULTS
  Statistically and clinically significant treatment responses were found.
  
  
  CONCLUSIONS
  These results support the use of methylphenidate in older, medically ill patients in whom rapid resolution of depressive symptoms is crucial.
authors.affiliation: VA Medical Centers in White River Junction, Vt. 05009, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Wallace
authors.forename: L L
authors.initials: LL
authors.lastname: Kofoed
authors.forename: A N
authors.initials: AN
authors.lastname: West
mesh_terms: D000367:Age Factors; D000368:Aged; D015897:Comorbidity; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D010919:Placebos; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D008774:Methylphenidate