E-cadherin as a tumor (invasion) suppressor gene.
Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.
Birchmeier
W
W
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
D025601:Adenomatous Polyposis Coli Protein; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000235:genetics; D003598:Cytoskeletal Proteins / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D009154:Mutation; D013274:Stomach Neoplasms / Q000235:genetics*
D025601:Adenomatous Polyposis Coli Protein; D015703:Antigens, CD; C050361:CDH2 protein, human; D015820:Cadherins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins