title: Therapeutic targets in osteoarthritis.
abstract: Osteoarthritis (OA) can be considered as a disease process, amenable to therapy, or as a consequence of evolution, resulting in special disadvantages to long lived humans. Possible therapeutic targets are considered for both models of the condition. Targets for a disease process might include inhibition of tissue destruction, or the stimulation of natural repair processes. Therapeutic targets for the disadvantages of OA include novel approaches to the treatment of pain and physical disability. The 2 approaches are not mutually exclusive, and both should be pursued.
authors.affiliation: Rheumatology Unit, University of Bristol, UK.
authors.forename: P
authors.initials: P
authors.lastname: Dieppe
mesh_terms: D004185:Disability Evaluation; D006801:Humans; D010003:Osteoarthritis / Q000503:physiopathology / Q000517:prevention & control; D010146:Pain / Q000209:etiology; D059408:Pain Management; D011379:Prognosis