The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene.
We show that the major role for Spo0A in the development of genetic competence is to downregulate expression of abrB. AbrB is both a negative regulator and a positive regulator of competence. The negative effects are exerted at multiple points in competence regulation. A regulatory mechanism that is independent of mecA and abrB operates on comK expression.
Hahn
J
J
Public Health Research Institute, New York, New York 10016, USA.
Roggiani
M
M
Dubnau
D
D
D001412:Bacillus subtilis / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology*; D001483:Base Sequence; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D015536:Down-Regulation / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D008969:Molecular Sequence Data; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*; D014169:Transformation, Bacterial / Q000235:genetics*
C060762:AbrB protein, Bacillus subtilis; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C080950:Spo0A protein, Bacillus subtilis; D014157:Transcription Factors