Chromosomal assignment of the human gene for the cancer-associated retinopathy protein (recoverin) to chromosome 17p13.1.
The gene for the mouse recoverin protein (23 kDa photoreceptor-specific protein, S-modulin, or the Cancer-Associated Retinopathy protein) was recently assigned to mouse chromosome 11, closely linked to trp53. In this paper, the human gene for recoverin was localized to human chromosome 17 by Southern analysis of restriction digests of the DNA from mouse/human somatic cell hybrids. Using a 7 kb subclone of the human recoverin gene, a positive fluorescence in situ hybridization signal was demonstrated near the terminus of the short arm of chromosome 17 at position p13.1. The mapping of recoverin to this region of human chromosome 17, which contains a number of cancer-related loci, suggests a possible mechanism by which cancer-associated retinopathy occurs in humans.
McGinnis
J F
JF
Department of Anatomy and Cell Biology, University of California, Los Angeles 90024, USA.
Austin
B
B
Klisak
I
I
Heinzmann
C
C
Kojis
T
T
Sparkes
R S
RS
Bateman
J B
JB
Lerious
V
V
D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005136:Eye Proteins; D015870:Gene Expression; D051597:Hippocalcin; D006801:Humans; D017403:In Situ Hybridization; D008074:Lipoproteins; D051379:Mice; D009369:Neoplasms / Q000235:genetics; D009419:Nerve Tissue Proteins; D051603:Recoverin; D012160:Retina / Q000502:physiology*
D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; C496732:Rcvrn protein, mouse; D051603:Recoverin; D051597:Hippocalcin