title: Use of high-resolution cytometry in predicting the biologic behavior of T1 adenocarcinoma of the lung.
abstract: Touch preparations from 60 cases of T1 adenocarcinoma were analyzed using a high-resolution, automated image cytometer. These cases were divided according to pathologic stage: stage I, 31; stage II, 3; stage III, 19; and stage IV, 7. For each nucleus 57 features were analyzed, and using a linear combination of three texture features describing the DNA distribution in the cell nucleus (TARL, ODMAX and FAREA1), aggressive cancer cells belonging to stage III/IV could be identified. The best discrimination between the stages was achieved when the frequency of aggressive cancer cells was 48%; the correct classification rate was 77%. Using this criterion, 22 of 27 patients (81%) who died of cancer within five years after surgery were correctly predicted. These results suggest that high-resolution cytometry may be of value in predicting the biologic behavior of adenocarcinoma cases, especially in stage I/II.
authors.affiliation: Department of Surgery, Tokyo Medical College Hospital, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ikeda
authors.forename: C
authors.initials: C
authors.lastname: MacAulay
authors.forename: S
authors.initials: S
authors.lastname: Lam
authors.forename: D M
authors.initials: DM
authors.lastname: Garner
authors.forename: P W
authors.initials: PW
authors.lastname: Payne
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: C
authors.initials: C
authors.lastname: Konaka
authors.forename: B
authors.initials: B
authors.lastname: Palcic
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000782:Aneuploidy; D003592:Cytophotometry / Q000379:methods*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm