Cell cycle regulators in the keratinocyte (cyclin-cdk).
It has recently become clear that cyclin-dependent kinase (cdk) complex regulates the cell cycle by phosphorylating Rb protein, a tumor suppressor protein. It is likely that this complex is a target of various growth factors and anti-growth factors (UV, TGF-beta etc.) in keratinocyte (KC). It has also been suggested that abnormalities in the cell cycle regulating mechanism such as increased activity of cyclin-cdk due to mutation of p53, a tumor suppressor gene, and overexpression of cyclin D may be concerned with carcinogenesis of KC. Thus, recent studies indicate that the cyclin-cdk complex is a common target of proliferation and carcinogenesis in KC.
Inohara
S
S
Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan.
Kitano
Y
Y
Kitagawa
K
K
D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism*; D016158:Genes, p53 / Q000235:genetics / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism; D009154:Mutation; D011493:Protein Kinase C / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53; D011493:Protein Kinase C; D018844:Cyclin-Dependent Kinases