title: Antigen-induced conformational changes in antibodies: a problem for structural prediction and design.
abstract: Recent work has shown that large conformational changes in antibodies can accompany antigen binding. These structural changes can alter dramatically the size, shape and charge distribution in the antigen-binding pocket, and may present problems for accurate modeling of antibody structures.
authors.affiliation: Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037.
authors.forename: R L
authors.initials: RL
authors.lastname: Stanfield
authors.forename: I A
authors.initials: IA
authors.lastname: Wilson
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry* / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D000906:Antibodies; D000941:Antigens