Proton NMR observation of the antineoplastic agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC).
We have noninvasively detected the proton signal of an antineoplastic agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
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Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025-2195, USA.
Bhujwalla
Z M
ZM
Maxwell
R J
RJ
Griffiths
J R
JR
Glickson
J D
JD
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism*; D001834:Body Water / Q000378:metabolism; D005354:Fibrosarcoma / Q000378:metabolism*; D006207:Half-Life; D006859:Hydrogen; D007274:Injections, Intraperitoneal; D007773:Lactates / Q000378:metabolism; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000378:metabolism*; D012983:Soft Tissue Neoplasms / Q000378:metabolism*; D013113:Spin Labels; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007773:Lactates; D009944:Organoplatinum Compounds; D013113:Spin Labels; C023359:iproplatin; D006859:Hydrogen