Cardiodynamic response to Escherichia coli endotoxemia: effects of fluid resuscitation.
We tested the influence of in vivo volume resuscitation on intrinsic contractile properties of left ventricular (LV) preparations of endotoxemic guinea pigs. Escherichia coli endotoxin (LPS)-injected animals were divided into nonresuscitated and resuscitated groups. Volume resuscitation improved cardiac output and stroke volume, increased arterial pH and body temperature, and decreased mortality. In isovolumetric LV preparations isolated 4 h after LPS injection, LV systolic pressures (in mmHg) preparations isolated 4 h after LPS injection, LV systolic pressures (in mmHg) of LPS with (42 +/- 3) and without (42 +/- 2) fluid resuscitation were consistently less than control values (70 +/- 3). LV end-diastolic pressure-volume (compliance) decreased in LPS-nonresuscitated hearts, while LV compliance of LPS-resuscitated hearts was similar to control. Thus, intravascular volume expansion selectively improved LV diastolic compliance of LPS hearts without affecting LV systolic function. These findings suggest that LV systolic and diastolic dysfunctions associated with endotoxemia and Gram-negative sepsis may involve separate pathogenic mechanisms.
Zhong
J
J
Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
Rubin
L J
LJ
Parker
J L
JL
Adams
H R
HR
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002302:Cardiac Output; D003326:Coronary Circulation; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli; D005440:Fluid Therapy; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D012016:Reference Values; D012151:Resuscitation / Q000379:methods*; D012772:Shock, Septic / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D013318:Stroke Volume; D013997:Time Factors
D004731:Endotoxins; D008070:Lipopolysaccharides