Effect of chelators, monoisoamyl meso-2,3-dimercaptosuccinate and N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbodit hioate, on cadmium and essential element levels in mice.
In experiments performed on male mice (ICR) the mobilizing effect of monoisoamyl meso-2,3-dimercaptosuccinate (Mi-ADMS) and a dithiocarbamate analogue, N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbod ithioate (MeBLDTC) on the cadmium deposits was studied. The influence of these compounds on the changes in the level of essential elements caused by cadmium was explored. CdCl2.H2O was injected intravenously. The chelators were administered every 48 h over 12 d. Both compounds are effective in mobilizing cadmium from the body in animal experiments. On an equimolar basis MeBLDTC was superior to Mi-ADMS. Mi-ADMS can, however, be administered orally. Both compounds were able to correct, at least partly, the changes in the level of essential elements caused by cadmium.
Eybl
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Department of Pharmacology, Charles University, Faculty of Medicine, Pilsen, Czech Republic.
Kotyzová
D
D
Koutenský
J
J
Jones
M M
MM
Singh
P K
PK
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002104:Cadmium / Q000378:metabolism*; D002614:Chelating Agents / Q000494:pharmacology*; D004187:Disaccharides / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D004113:Succimer / Q000031:analogs & derivatives* / Q000494:pharmacology; D013737:Testis / Q000187:drug effects / Q000378:metabolism; D013859:Thiocarbamates / Q000494:pharmacology*
D002614:Chelating Agents; D004187:Disaccharides; C091507:N-(4-methylbenzyl)-4-O-galactopyranosyl-glucamine-N-carbodithioate; D013859:Thiocarbamates; D002104:Cadmium; C091888:monoisoamyl-2,3-dimercaptosuccinate; D004113:Succimer