Stimulation of nerve growth factor synthesis and secretion by fellutamide A in vitro.
Fellutamide A, a tripeptide derivative from Penicillium fellutanum was found to be a potent enhancer of nerve growth factor (NGF) synthesis and secretion in vitro. This compound enhanced production of NGF in L-M cells, rat brain cells, and rat glial cells. The mode of action of this compound was suggested to be different from that of a known NGF inducer, epinephrine, as inducing activities of fellutamide A and epinephrine were additive when they were admixed at the concentration which gave saturation in its respective activity. Furthermore, fellutamide A but not epinephrine induced production of NGF in the rat brain cells. NGF-inducing activity of several tripeptides and other compounds related to fellutamide A was examined.
Yamaguchi
K
K
Sagami Chemical Research Center, Kanagawa, Japan.
Tsuji
T
T
Wakuri
S
S
Yazawa
K
K
Kondo
K
K
Shigemori
H
H
Kobayashi
J
J
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000166:cytology; D001923:Brain Chemistry / Q000187:drug effects; D002642:Chick Embryo; D003609:Dactinomycin / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000378:metabolism; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013268:Stimulation, Chemical
D009414:Nerve Growth Factors; D009842:Oligopeptides; C080556:fellutamide A; D003609:Dactinomycin; D004837:Epinephrine