title: Monocyte chemotactic protein 1 is released during lethal and sublethal bacteremia in baboons.
abstract: The chemokine monocyte chemotactic protein 1 (MCP-1) is a cytokine with chemotactic activity specific for mononuclear phagocytes. To investigate the possible involvement of MCP-1 in the pathogenesis of sepsis, its course was studied in baboons challenged intravenously with a sublethal or lethal dose of Escherichia coli. Levels of MCP-1 started to increase in both groups of animals 2 h after injection of E. coli, reaching peak levels 4 and 6 h after a sublethal (186 +/- 21 ng/mL) or a lethal (213 +/- 24 ng/mL) dose, respectively. Levels of MCP-1 correlated significantly with plasma levels of another chemokine, interleukin-8 (IL-8; r = .826. P < .001), suggesting that common stimuli mediate the release of both cytokines in this model.
authors.affiliation: Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam.
authors.forename: P M
authors.initials: PM
authors.lastname: Jansen
authors.forename: J
authors.initials: J
authors.lastname: van Damme
authors.forename: W
authors.initials: W
authors.lastname: Put
authors.forename: I W
authors.initials: IW
authors.lastname: de Jong
authors.forename: F B
authors.initials: FB
authors.lastname: Taylor
authors.forename: C E
authors.initials: CE
authors.lastname: Hack
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000097:blood*; D018932:Chemokine CCL2; D002630:Chemotactic Factors / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D004927:Escherichia coli Infections / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D010215:Papio; D013997:Time Factors
chemical_list: D018932:Chemokine CCL2; D002630:Chemotactic Factors; D016207:Cytokines; D016209:Interleukin-8