The in vitro effect of sodium mercaptoundecahydrododecaborate (borocaptate) on sulfhydryl groups of different rat tissues.
The effect of borocaptate on structural protein sulfhydryl (SH) groups of different organs and kidney subcellular fractions was studied in vitro. It was shown that the binding capacity of borocaptate is not the same for different tissues and subcellular fractions. The highest binding capacity was in the liver, while kidney and brain values were significantly lower. Therefore, it appears that the same concentration of borocaptate may have different effects in various organs.
Buchar
E
E
Institute of Pharmacology, Czech Academy of Sciences, Prague.
Horn
V
V
Kameníková
L
L
Janku
I
I
D000818:Animals; D001665:Binding Sites; D001894:Borohydrides / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D016754:Boron Neutron Capture Therapy; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002458:Cell Fractionation; D002467:Cell Nucleus / Q000737:chemistry / Q000187:drug effects; D003600:Cytosol / Q000737:chemistry / Q000187:drug effects; D004228:Dithionitrobenzoic Acid / Q000737:chemistry; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000737:chemistry / Q000187:drug effects; D008928:Mitochondria / Q000737:chemistry / Q000187:drug effects; D011506:Proteins / Q000737:chemistry / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D014018:Tissue Distribution
D001894:Borohydrides; D011506:Proteins; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D004228:Dithionitrobenzoic Acid