Antimicrobial properties of delmopinol against oral bacteria.
Antimicrobial properties of the morpholine derivative delmopinol hydrochloride were investigated in vitro. Minimum inhibitory concentrations were measured for a range of oral bacteria by broth and agar dilution techniques and minimum bactericidal concentrations were measured in broth. The rate of kill was investigated by determination and analysis of kill curves. The results indicated that delmopinol is a relatively weak antimicrobial in comparison with chlorhexidine. However, it may selectively affect certain species of oral bacteria which are of importance in plaque formation.
Elworthy
A J
AJ
Department of Oral and Dental Science, University of Bristol, UK.
Wade
W G
WG
D002710:Chlorhexidine / Q000494:pharmacology; D003470:Culture Media / Q000737:chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000494:pharmacology*; D009055:Mouth / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development
D003470:Culture Media; D009025:Morpholines; C073738:delmopinol; D002710:Chlorhexidine