title: Dynamic lipid heterogeneity and receptor events.
abstract: Receptor occupation by specific ligands induces changes in the dynamic domain organization of surrounding lipids. Such changes were observed by measuring changes in the fluorescence parameters of fluorescent-labelled lipids incorporated into plasma membranes of intact cells, membrane vesicles or lipoprotein particles in response to specific binding of a broad range of biologically active agents, including drugs, prostaglandins, neuropeptides, antibodies and viruses. The high sensitivity of the fluorescence response allowed us to register changes in lipid heterogeneity induced in a multitude of discrete targets by transient weak binding of a single rapidly translocating molecule. To explain these observations a non-equilibrium model of ligand-receptor interaction based on low relaxation phenomena in heterogeneous lipid matrixes is proposed.
authors.affiliation: School of Pharmacy, Hebrew University of Jerusalem, Israel.
authors.forename: L D
authors.initials: LD
authors.lastname: Bergelson
mesh_terms: D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000502:physiology*
chemical_list: D008563:Membrane Lipids; D011956:Receptors, Cell Surface