title: Adrenocortical carcinoma: MR imaging appearance with current techniques.
abstract: The purpose of the study was to define the magnetic resonance (MR) imaging appearance of adrenocortical carcinoma (ACC) with current MR techniques. Eight patients with ACC underwent high-field-strength MR imaging with the following sequences: axial T1-weighted gradient echo, fat-suppressed T1-weighted spin echo, fat-suppressed T2-weighted spin echo, and gadolinium-enhanced T1-weighted gradient echo and fat-suppressed T1-weighted spin echo. Postcontrast images were also acquired in the sagittal (six patients) and coronal (three patients) planes. Out-of-phase gradient-echo images were obtained in two patients. Lesion morphology, signal intensity features, and presence of metastatic disease were retrospectively evaluated. MR imaging features of ACC included internal hemorrhage (seven of eight patients), central necrosis (seven of eight), and peripheral enhancing nodules (seven of eight). Out-of-phase images in two of two patients demonstrated signal loss compared with in-phase images, which may be a common feature of these tumors. Liver metastases were present in four patients. Consistent MR features of ACC are identified.
authors.affiliation: Department of Radiology, University of North Carolina, Chapel Hill 17599-7510, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Schlund
authors.forename: P J
authors.initials: PJ
authors.lastname: Kenney
authors.forename: E D
authors.initials: ED
authors.lastname: Brown
authors.forename: S M
authors.initials: SM
authors.lastname: Ascher
authors.forename: J J
authors.initials: JJ
authors.lastname: Brown
authors.forename: R C
authors.initials: RC
authors.lastname: Semelka
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000175:diagnosis* / Q000556:secondary; D000328:Adult; D000368:Aged; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA