[Polycyclic azines with heteroatoms in the 1- and 3-position. 40. Synthesis of heterocyclic immunomodulators. 2. 3-Mercaptoalkylthieno(2,3-d)pyrimidine-2,4(1H,3H)-diones: synthesis and testing of immunostimulant activity].
A series of 3-mercaptoalkylthieno[2,3-d]pyrimidine-2,4(1H,3H)-diones 3 was prepared and their immuno-stimulating activity was examined. The title compounds were obtained conveniently by hydrolytic ring cleavage of fused thiazolo- or 1,3-thiazino-thienopyrimidines 1 under alkaline or acidic reaction conditions. The ms fragmentation of the thieno[2,3-d]pyrimidine-2,4-diones 3 is discussed. In the delayed type hypersensitivity (DTH) test some compounds 3 showed immuno-stimulating activities in the range of isoprinosine.
Gütschow
M
M
Institut für Pharmazie, Universität Leipzig, Leipzig.
Drössler
K
K
Leistner
S
S
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D013058:Mass Spectrometry; D051379:Mice; D008808:Mice, Inbred CBA; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D011743:Pyrimidines
Mehrcyclische Azine mit Heteroatomen in 1- und 3-Stellung, 40. Mitt.; Synthese heterocyclischer Immunmodulatoren, 2. Mitt.: 3- Mercaptoalkylthieno[2,3-d]pyrimidin-2,4(1H,3H)-dione: Synthese und Prüfung auf immunstimulatorische Wirksamkeit.