Sequences of the 5'-flanking region of the human helix-loop-helix protein-encoding Id2A gene, and promoter activity regulated by serum and c-Jun/AP-1.
The 5'-flanking region of the human Id2A gene between nt -1213 and +36 from the putative transcription start point was sequenced. Transient transfection studies showed that the region between nt -834 and +30 directs the expression of a reporter gene and contains regulatory elements responsive to serum and c-Jun/AP-1 over production.
Kurabayashi
M
M
Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.
Jeyaseelan
R
R
Kedes
L
L
D001483:Base Sequence; D003470:Culture Media; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D006367:HeLa Cells; D018257:Helix-Loop-Helix Motifs; D006801:Humans; D051798:Inhibitor of Differentiation Protein 1; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics*; D016755:Proto-Oncogene Proteins c-jun; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D012097:Repressor Proteins; D017422:Sequence Analysis, DNA; D018808:Transcription Factor AP-1; D014157:Transcription Factors
D003470:Culture Media; D004268:DNA-Binding Proteins; C497453:ID1 protein, human; D051798:Inhibitor of Differentiation Protein 1; D016755:Proto-Oncogene Proteins c-jun; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins; D018808:Transcription Factor AP-1; D014157:Transcription Factors