title: In vitro and in vivo effects of somatostatin on the growth of A431 cells.
abstract: We previously reported that the octapeptide somatostatin (SS) analogue SMS 201-995 (SMS) unexpectedly stimulates the growth of A431 human epidermoid carcinoma cells in vitro. In the present study, we found that both SS-14 and SS-28 also stimulated the growth of A431 cells in vitro. The proliferative effect of SS-28 also stimulated the growth of A431 cells in vitro. The proliferative effect of SS-28 was greater than that of SS-14. In contrast, there was no difference in A431 cell tumor weight or area between the SMS-treated or untreated athymic, tumor-bearing mice. The serum epidermal growth factor (EGF) level of the SMS-treated mice was significantly lower than that of the untreated mice. Decreases in serum EGF may attenuate the proliferative effect of SMS in vivo.
authors.affiliation: Third Department of Internal Medicine, Nagoya City University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kamiya
authors.forename: J
authors.initials: J
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Horie
authors.forename: M
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: R
authors.initials: R
authors.lastname: Hori
authors.forename: N
authors.initials: N
authors.lastname: Sakuma
authors.forename: T
authors.initials: T
authors.lastname: Fujinami
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000097:blood; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D013004:Somatostatin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D013004:Somatostatin; D004815:Epidermal Growth Factor