title: Isolation of tautomycetin as a regulator of secondary metabolite production for Penicillium urticae.
abstract: Tautomycetin was isolated as a regulator of secondary metabolite production for Penicillium urticae. It induced the simultaneous production of a yellow compound, named patulodin, and of patulolides against P. urticae P3, which does not produce such metabolites under the usual conditions. Tautomycin, a phosphatase inhibitor, also caused the same phenomenon.
authors.affiliation: Department of Biotechnology, Faculty of Engineering, Osaka University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sakuda
authors.forename: K
authors.initials: K
authors.lastname: Miki
authors.forename: S
authors.initials: S
authors.lastname: Kitaoka
authors.forename: M
authors.initials: M
authors.lastname: Reugjitchachawaly
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000900:Anti-Bacterial Agents / Q000097:blood*; D000903:Antibiotics, Antineoplastic / Q000097:blood*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003470:Culture Media; D004852:Epoxy Compounds / Q000097:blood; D005663:Furans; D008055:Lipids; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000187:drug effects / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors; D011714:Pyrans; D013141:Spiro Compounds; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D003470:Culture Media; D004852:Epoxy Compounds; D005663:Furans; D008055:Lipids; D018942:Macrolides; D011714:Pyrans; D013141:Spiro Compounds; C092180:patulodin; C053079:tautomycin; C058744:tautomycetin; D010744:Phosphoric Monoester Hydrolases