Selective lysis of cultures and cell walls of penicillin-resistant but not penicillin-susceptible Streptococcus pneumoniae strains by a murein hydrolase complex.
A murein hydrolase complex selectively lysed cultures of penicillin-resistant pneumococci and their cell walls in which the majority of muropeptide subunits were indirectly cross-linked through oligopeptide substituents (alanyl-alanine or alanyl-serine) on the epsilon-amino group of the stem peptide lysine residues. Walls of penicillin-susceptible strains were not hydrolyzed.
Severin
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Laboratory of Microbiology, Rockefeller University, New York, New York 10021, USA.
Tomasz
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D000595:Amino Acid Sequence; D001433:Bacteriolysis; D002473:Cell Wall / Q000378:metabolism*; D008969:Molecular Sequence Data; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000494:pharmacology*; D010403:Penicillin Resistance; D010446:Peptide Fragments / Q000737:chemistry; D010447:Peptide Hydrolases / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D016959:Xanthomonas campestris / Q000201:enzymology
D010446:Peptide Fragments; C060332:lysoamidase; D010447:Peptide Hydrolases; D009238:N-Acetylmuramoyl-L-alanine Amidase