title: Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor. II.
abstract: To search for possible anti-tumor-promoters, we carried out a primary screening of twenty-four 29-nor-cucurbitacin glucosides isolated from the roots of Cayaponia tayuya (Cucurbitaceae) using an in vitro synergistic assay system. Of these glucosides, cayaponosides B (5), B3 (7), D (8), D3b (22) and C2 (23) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, 5 and 23 exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Konoshima
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
authors.forename: M
authors.initials: M
authors.lastname: Kozuka
authors.forename: T
authors.initials: T
authors.lastname: Nagao
authors.forename: H
authors.initials: H
authors.lastname: Okabe
authors.forename: N
authors.initials: N
authors.lastname: Irino
authors.forename: T
authors.initials: T
authors.lastname: Nakasumi
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Nishino
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D014315:Triterpenes