[Comparative study, using a placebo, of the frequency of micturition after repeated administration of piretanide SR 6 mg/day (Eurelix) to healthy volunteers].
Thirty healthy volunteers received piretanide SR 6 mg/day (n = 15) or placebo (n = 15) in a 10-day double-blind parallel-group comparative trial. 24-h urine output was significantly greater with piretanide than with placebo on D1 (1919 +/- 434 ml and 1160 +/- 335 ml respectively, p = 0.001 one-sided) as on D10 (1563 +/- 538 ml and 1236 +/- 435 ml respectively, p = 0.04 one-sided). Nevertheless the evolution of urinary output from D1 to D10 was significantly different (p = 0.008): it remained stable with placebo but diminished with piretanide. The diuretic effect of piretanide was apparent with a supplementary miction between 8 a.m. and 4 p.m. both on D1 and D10. Between 4 p.m. and 8 a.m., the number of mictions was the same in both groups. Thus piretanide SR 6 mg has a mild effect on the number of mictions; it should not alter patients' well-being.
Genthon
R
R
Laboratoires Hoechst, Paris la Défense, France.
Chassard
D
D
Derobert
E
E
Kabir
M
M
Lendresse
P
P
D000328:Adult; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D015989:Healthy Worker Effect; D006801:Humans; D008297:Male; D010919:Placebos; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D014555:Urination Disorders / Q000139:chemically induced* / Q000453:epidemiology; D014838:Volunteers
D004232:Diuretics; D010919:Placebos; D013449:Sulfonamides; C015451:piretanide
Etude comparative au placebo de l'évolution de la fréquence des mictions sous pirétanide 6 mg L.P. (Eurélix) en administration réiterée chez le volontaire sain.