Optimizing the composition of bone marrow for allogenic transplantation.
Graft versus host disease, graft failure, and disease relapse remain significant impediments to successful allogeneic transplantation. Ex vivo engineering of the graft offers the opportunity to modify the cellular composition to overcome these problems. This review describes recent developments that employ this approach.
Champlin
R
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Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
D001773:Blood Cells / Q000473:pathology; D016026:Bone Marrow Transplantation; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D016130:Immunophenotyping; D014184:Transplantation, Homologous / Q000473:pathology / Q000592:standards