title: Support studies for installing the phosphodiester residues of the Thy-1 glycoprotein membrane anchor.
abstract: Support studies for late-stage installation of the three different types of phosphodiesters found in the rat brain Thy-1 glycoprotein membrane anchor are described. The strategy is geared towards optimizing convergency and the development of chemoselective procedures including deprotection, phosphorylation, esterification and cysteinylation has been investigated. Some of these procedures are being designed for oligosaccharides containing several unprotected hydroxy groups.
authors.affiliation: Paul M. Gross Chemical Laboratory, Department of Chemistry, Duke University, Durham, NC 27708, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Campbell
authors.forename: B
authors.initials: B
authors.lastname: Fraser-Reid
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D003545:Cysteine / Q000737:chemistry; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism; D010755:Organophosphates / Q000138:chemical synthesis*; D051381:Rats; D018800:Thy-1 Antigens / Q000737:chemistry*
chemical_list: D017261:Glycosylphosphatidylinositols; D009844:Oligosaccharides; D010755:Organophosphates; D018800:Thy-1 Antigens; D003545:Cysteine