A cyanobacterial gene encoding a protein with extensive homology to mammalian phosphoribosylpyrophosphate synthetase.
Phosphoribosylpyrophosphate (PRibPP) is the primary precursor in the biosynthesis of purine and pyrimidine nucleotides. The synthesis of PRibPP is catalysed by a ubiquitous PRibPP synthetase in many organisms. We provide evidence that a cyanobacterium, Synechococcus sp., has a gene encoding a protein with striking homology to mammalian PRibPP synthetases.
Nagaya
M
M
Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Japan.
Aiba
H
H
Mizuno
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000458:Cyanobacteria / Q000201:enzymology / Q000235:genetics*; D005798:Genes, Bacterial; D008322:Mammals; D008969:Molecular Sequence Data; D012268:Ribose-Phosphate Pyrophosphokinase / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D012268:Ribose-Phosphate Pyrophosphokinase