title: Coenzyme Q10 levels, plasma lipids and peroxidation extent in renal failure and in hemodialytic patients.
abstract: Coenzyme Q10 (CoQ10), vitamin E, triglycerides and conjugated dienes were measured in a group of 48 patients on chronic hemodialysis, in 15 uremic patients and in a control group of 10 normal subjects. CoQ10 levels were significantly lower (P < 0.001) in both hemodialytic and uremic patients compared with the normal group whereas triglycerides were significantly higher (P < 0.001) with respect to both normal subjects and uremic patients. Conjugated dienes were significantly higher (P < 0.001) in both hemodialytic and uremic patients with respect to normal subjects. The predialytic values of vitamin E were higher in hemodialytic patients with respect to both normal subjects and uremic patients whereas the postdialytic values were in the normal range. A restoration mechanism of vitamin E after hemodialytic treatment was hypothesized.
authors.affiliation: Istituto di Chimica e Chimica Clinica, Università Cattolica del S. Cuore.
authors.forename: S
authors.initials: S
authors.lastname: Lippa
authors.forename: L
authors.initials: L
authors.lastname: Colacicco
authors.forename: C
authors.initials: C
authors.lastname: Callà
authors.forename: G
authors.initials: G
authors.lastname: Sagliaschi
authors.forename: A G
authors.initials: AG
authors.lastname: Angelitti
mesh_terms: D000328:Adult; D000368:Aged; D003067:Coenzymes; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014511:Uremia / Q000097:blood / Q000628:therapy; D014810:Vitamin E / Q000097:blood*
chemical_list: D003067:Coenzymes; D008055:Lipids; D014280:Triglycerides; D014451:Ubiquinone; D014810:Vitamin E; C024989:coenzyme Q10