Why do adipocytes make the beta 3 adrenergic receptor?
Adipocytes express a mixture of beta-adrenergic receptor subtypes, including the recently characterized beta 3 receptor. The co-expression of these subtypes by fat cells suggest they serve different signalling functions. In this review, the properties of recombinant and natively-expressed beta 3 receptors are detailed and contrasted with those of beta 1 and beta 2 receptors. The beta 3 receptor appears to differ from the other beta receptor subtypes with respect to receptor coupling efficiency, G-protein coupling specificity and regulation by agonist exposure. Lastly, the potential of the beta 3 receptor as a therapeutic target is discussed in view of new data regarding its tissue distribution in humans.
Granneman
J G
JG
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201, USA.
D017667:Adipocytes / Q000502:physiology*; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D011943:Receptors, Adrenergic, beta / Q000096:biosynthesis / Q000502:physiology*; D018342:Receptors, Adrenergic, beta-1 / Q000502:physiology; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology; D022702:Receptors, Adrenergic, beta-3; D011994:Recombinant Proteins
D011943:Receptors, Adrenergic, beta; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2; D022702:Receptors, Adrenergic, beta-3; D011994:Recombinant Proteins; D019204:GTP-Binding Proteins