title: Effects of acoustic overstimulation on 2f1-f2 distortion product in the cochlear microphonics.
abstract: The cochlear microphonics (CM) in response to two-tone stimuli as well as the threshold of compound action potential (CAP) were measured before and after exposure to 4 kHz pure tone at 100 dB SPL for 10 min. Although the loss of CM output at the primary frequencies was limited to around 2 dB, the 2f1-f2 distortion products in the CM (CM-DPs) were markedly reduced immediately after the exposure, especially at low primary levels (i.e. less than 65 dB). The low level CM-DPs recovered gradually near the initial level within 7 days from the exposure. The elevation of CAP threshold closely paralleled with the reduction of CM-DPs in not only the acute phase but also in the recovery phase from the exposure. These results show that the active transduction process in the cochlea was affected by acoustic overstimulation. This impairment of the active transduction was postulated to play an important role in developing the noise induced temporary threshold shift.
authors.affiliation: Department of Otorhinolaryngology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
authors.forename: K
authors.initials: K
authors.lastname: Makishima
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology*; D003051:Cochlea / Q000502:physiology*; D004594:Electrophysiology; D006168:Guinea Pigs; D006316:Hearing Loss, High-Frequency; D015398:Signal Transduction / Q000502:physiology; D014139:Tracheostomy