Intravenous enterostatin does not affect single meal food intake in man.
Enterostatin, a pentapeptide released with colipase from pancreatic procolipase in man, affects eating behaviour in animals. We report the first phase II study of intravenous (i.v.) enterostatin (D3800) in obese but otherwise healthy men. Eighteen men (mean age 37 years, mean body mass index 34.9 kg/m2) completed a double-blind, randomized, crossover placebo controlled trial. After in initial session, each man received i.v. 4 mg D3800, 16 mg D3800 or placebo in random order over three sessions, immediately before a test meal served on a universal eating monitor. No statistically significant effect of i.v. enterostatin on any uptake or rating variable was observed. Several factors may explain the lack of effect, e.g. the inability of i.v. enterostatin to reach a site of action, the time between i.v. administration and eating, and the possibility that the only human responders are those who express particular fat preferences.
Rössner
S
S
Obesity Unit, Karolinska Hospital, Stockholm, Sweden.
Barkeling
B
B
Erlanson-Albertsson
C
C
Larsson
P
P
Wåhlin-Boll
E
E
D000328:Adult; D000595:Amino Acid Sequence; D003089:Colipases / Q000008:administration & dosage / Q000494:pharmacology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D004792:Enzyme Precursors; D005518:Food Preferences / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009765:Obesity / Q000188:drug therapy; D010919:Placebos; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology*
D003089:Colipases; D004792:Enzyme Precursors; D010919:Placebos; D011498:Protein Precursors; C037107:procolipase