[Activation-dependent expression of Fc gamma-receptors on glomerular mesangial cells].
Resting, non-cycling mesangial cells (MCs) can be induced by IFN gamma to express the Fc gamma-RIIIa and Fc epsilon RI-gamma subunits of the CD16TM receptor complex. After cell surface expression of CD16TM by IFN gamma induction the binding of immune complexes to MCs induces IL-6 secretion. A Fc epsilon RI-gamma gene knockout has recently been described. It is now possible to study the function of Fc gamma RIIIa and other gamma chain associated Fc receptors in the initiation and progression of chronic glomerular inflammation in the context of the intact immune system in vivo.
Gessner
J E
JE
Abteilungen Immunologie und Transfusionsmedizin, Medizinischen Hochschule Hannover.
Radeke
H H
HH
Uciechowski
P
P
Resch
K
K
Schmidt
R E
RE
D000818:Animals; D015870:Gene Expression; D005920:Glomerular Mesangium / Q000378:metabolism*; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D017452:Receptors, IgG / Q000235:genetics / Q000378:metabolism*
D008070:Lipopolysaccharides; D012333:RNA, Messenger; D017452:Receptors, IgG
Aktivierungsabhängige Expression von Fc gamma-Rezeptoren auf glomerulären Mesangialzellen.