title: Computer controllability experiments on a cardiac action potential model.
abstract: Recent advances in single cell and single channel recording techniques have lead to the generation of more accurate descriptions of cardiac muscle cell ion channel kinetics and the development of a new mathematical model of its action potential, the Luo and Rudy model. In order to study the propagation, effects of drugs by spatial simulations, it is first necessary to develop a means to control some characteristics of action potential given by this model. Presented here are the results of computer implementation, validation, and controllability experiments of the Luo-Rudy model of cardiac action potential.
authors.affiliation: National Technical University of Athens, Department of Electrical and Computer Engineering, Greece.
authors.forename: C V
authors.initials: CV
authors.lastname: Papadopoulos
authors.forename: S M
authors.initials: SM
authors.lastname: Capetanaki
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D003198:Computer Simulation; D006321:Heart / Q000502:physiology*