Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease.
NADPH-diaphorase histochemistry labels neurons containing nitric oxide synthase, the synthesizing for nitric oxide within the central nervous system. Quantitation revealed a statistically significant increase in the density of intensely (type 1) and moderately (type 2) but not lightly (type 3) NADPH-diaphorase stained neurons within the substantia innominata in AD as compared with age-matched controls. Increased numbers of NADPH-diaphorase neurons suggest excess nitric oxide production which may be neurotoxic to surrounding cholinergic neurons within the substantia innominata in Alzheimer's disease.
Benzing
W C
WC
Department of Neurological Sciences, Alzheimer's Disease Center, Rush Presbyterian St Luke's Medical Center, Chicago, IL 60612, USA.
Mufson
E J
EJ
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology* / Q000473:pathology; D002452:Cell Count; D006651:Histocytochemistry; D006801:Humans; D009252:NADPH Dehydrogenase / Q000032:analysis*; D009474:Neurons / Q000201:enzymology*; D013377:Substantia Innominata / Q000166:cytology / Q000201:enzymology*
D009252:NADPH Dehydrogenase