title: The effect of removing external sodium upon the cholinergic regulation of potassium permeability in the rat submandibular gland in vitro.
abstract: Fragments of rat submandibular gland were loaded with 86Rb+ and superfused so that the rate of 86Rb(+)-efflux could be quantified as an indicator of potassium permeability. Acetylcholine evoked an increase in permeability consisting of a transient, calcium-independent response and a sustained, calcium-dependent. Total removal of external sodium significantly inhibited both phases of this response. The results thus confirm that the cholinergic regulation of potassium permeability is compromised by removal of external sodium but do not support the view that this is due, exclusively, to an effect on calcium influx.
authors.affiliation: Institute of Physiology, University of Glasgow, U.K.
authors.forename: J D
authors.initials: JD
authors.lastname: Pediani
authors.forename: P E
authors.initials: PE
authors.lastname: McEwan
authors.forename: H Y
authors.initials: HY
authors.lastname: Elder
authors.forename: S M
authors.initials: SM
authors.lastname: Wilson
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002132:Calcium Radioisotopes; D003470:Culture Media; D066298:In Vitro Techniques; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012414:Rubidium Radioisotopes; D012964:Sodium / Q000502:physiology*; D013363:Submandibular Gland / Q000294:innervation / Q000378:metabolism*
chemical_list: D002132:Calcium Radioisotopes; D003470:Culture Media; D012414:Rubidium Radioisotopes; D012964:Sodium; D000109:Acetylcholine; D011188:Potassium