Stereotactic external beam irradiation using a linear accelerator: the Washington University experience.
From February 1989 to December 1993, 139 patients with a variety of brain lesions were treated with stereotactic external beam irradiation using a 6MV linear accelerator. The largest group consisted of patients with recurrent brain metastases (n = 46). Twenty seven patients had malignant gliomas, most of which were recurrent. Several benign conditions were treated, including arteriovenous malformations (n = 27), acoustic neuromas (n = 9), meningiomas (n = 7), and pituitary adenomas (n = 2). Durable responses were seen in the majority of patients with transient, mild, side effects. This experience suggests that stereotactic external beam irradiation is a safe, reliable, and effective method for non-invasive treatment of selected patients with small, localized brain lesions.
Simpson
J R
JR
Radiation Oncology Center, Washington University School of Medicine, Jewish Hospital of St. Louis, Missouri.
Rich
K M
KM
Drzymala
R E
RE
Wasserman
T H
TH
Klein
E E
EE
Michaletz-Lorenz
M
M
Maurath
J
J
Filiput
E
E
D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis / Q000532:radiotherapy*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008279:Magnetic Resonance Imaging; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods; D011882:Radiotherapy, High-Energy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014861:Washington