title: [Levamisole- and tetramisole-resistant gastrointestinal nematodes in sheep].
abstract: Two experiments were carried out with sheep naturally infected with gastrointestinal nematodes to evaluate efficacy of anthelmintics using in vivo faecal egg count reduction (FECR) test. In experiment 1 with 28 ewes, the following efficacy of anthelmintics given at recommended dose rates was observed: albendazole 99.4%, ivermectin 99.3% and levamisole 81.8%. In experiment 2 with 18 ewes, tetramisole exhibited 71.3% efficacy. Suspected resistance to imidothiazole anthelmintics was confirmed by in vitro larval development test (LDT)--minimal inhibition concentration (MIC) values were estimated at 2.0 micrograms/ml. Infective larvae L3 cultivated from eggs produced by the population of resistant helminths were identified as Ostertagia and Trichostrongylus spp.
authors.affiliation: Institute of Parasitology, Slovak Academy of Sciences, Kosice.
authors.forename: J
authors.initials: J
authors.lastname: Praslicka
authors.forename: P
authors.initials: P
authors.lastname: Pilko
authors.forename: M
authors.initials: M
authors.lastname: Várady
authors.forename: J
authors.initials: J
authors.lastname: Corba
mesh_terms: D000818:Animals; D004351:Drug Resistance; D005243:Feces / Q000469:parasitology; D007978:Levamisole / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D013773:Tetramisole / Q000627:therapeutic use*; D014251:Trichostrongyloidea / Q000187:drug effects; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
chemical_list: D007978:Levamisole; D013773:Tetramisole
vernacular_title: Nález gastrointestinálnych nematódov u oviec rezistentných k levamizolu a tetramizolu.