Effects of zaizhang-I, a traditional Chinese herbal medicine, on hematopoietic recovery from radiation injury in mice.
Effects of Zaizhang-I (ZZ-I) on the recovery of hemopoietic systems from radiation injury were investigated. Mice, irradiated with 6.0 Gy-rays, were injected i.p. once daily for 7 consecutive days with either ZZ-I or saline (0.01 ml/g body wt.). The experiments showed that ZZ-I significantly promoted the recovery of not only peripheral WBC, BMC, CFU-S and CFU-GM but also the abnormal femur micro-vessel system such as blood vessels and sinus ectasia, hyperemia and hemorrhage etc. These results suggest that ZZ-I could accelerate hemopoietic recovery from radiation injury in mice by stimulating hemopoietic stem cells and improving hemopoietic inductive microenvironment (HIM).
Yang
M W
MW
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Medical University, Wuhan.
He
M D
MD
Li
M Z
MZ
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; C093678:zaizhang I