Cardiac arrest following an iatrogenic 3,4-diaminopyridine intoxication in a patient with Lambert-Eaton myasthenic syndrome.
Syndromes with impaired neuromuscular transmission are frequently treated with pyridine derivates. 3,4-diaminopyridine is thought to have fewer side effects than the commonly used, but less potent, 4-aminopyridine. We describe a patient with an initially unrecognized iatrogenic intoxication with 3,4-diaminopyridine. Except for a life threatening arrhythmia, symptoms were similar to a 4-aminopyridine intoxication. The patient made a full recovery with symptomatic treatment and withdrawal of the drug.
Boerma
C E
CE
Lukas Hospital Apeldoorn, The Netherlands.
Rommes
J H
JH
van Leeuwen
R B
RB
Bakker
J
J
D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000506:poisoning / Q000627:therapeutic use; D000368:Aged; D000077770:Amifampridine; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D007049:Iatrogenic Disease; D015624:Lambert-Eaton Myasthenic Syndrome / Q000188:drug therapy*
D015761:4-Aminopyridine; D000077770:Amifampridine