title: Dermonecrotic activity of a cell wall preparation from Fusobacterium necrophorum.
abstract: A cell wall preparation of Fusobacterium necrophorum induced haemorrhagic necrosis in the skins of guinea pigs and rabbits. Effects in mice and rats were weak or absent. The toxic activity of the cell wall preparation was not reduced by heat treatment. A dermonecrotic toxin was isolated from the cell wall preparation with sodium dodecylsulphate and concentrated by precipitation with ethanol. A preparation of the bacterial cytoplasm from Fus. necrophorum induced mainly erythema.
authors.affiliation: Department of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kanoe
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Kai
authors.forename: H
authors.initials: H
authors.lastname: Blobel
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000302:isolation & purification; D001688:Biological Products / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D002473:Cell Wall / Q000737:chemistry; D004890:Erythema / Q000209:etiology; D005675:Fusobacterium necrophorum; D006168:Guinea Pigs; D006358:Hot Temperature; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009336:Necrosis / Q000209:etiology; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000473:pathology*
chemical_list: D001427:Bacterial Toxins; D001688:Biological Products