title: Heparin-rebound in the early postoperative phase following cardiopulmonary bypass.
abstract: The incidence of the 'heparin-rebound' phenomenon after protamine neutralization of systemic heparinization required for cardiopulmonary bypass (CPB) was investigated. Heparin-effect was detected in 43% of patients studied at 2 h, 31% at 4 h, and 37% at 8 h after reversal of circuit heparin on CPB. Heparin-rebound was shown to be associated with a small but significant increase in postoperative bleeding which was not of clinical importance.
authors.affiliation: Cardiothoracic Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Subramaniam
authors.forename: P
authors.initials: P
authors.lastname: Skillington
authors.forename: J
authors.initials: J
authors.lastname: Tatoulis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002315:Cardiopulmonary Bypass; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy*; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D011446:Prospective Studies; D011479:Protamines / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011479:Protamines; D006493:Heparin