title: [Temporal relationship between food intake, administration of insulin and physical loading in type I diabetics treated with an intensified insulin regimen].
abstract: BACKGROUND
  Although there is no doubt about the benefit of physical exercise in diabetic patients, risks of exercise are known in particular in type 1 diabetics. The purpose of the investigation was to assess the optimal time of exercise in relation to food intake and insulin administration in type 1 diabetics treated by intensified insulin regimens.
  
  
  RESULTS
  The group comprised 31 type 1 diabetic patients without complications (21 women, 11 men) mean age 26 years, range 18-32 years with a mean duration of diabetes of 9 +/- 5.3 years and a BMI of 24.7 +/- 2.3. The patients were treated by intensified insulin regimens. In order to evaluate the blood sugar reaction they were subjected to a physical load amounting to 50% of the maximal oxygen consumption (VO2max) after exercise in the morning on fasting (state I), after administration of an insulin bolus and after breakfast (stage II) and after administration of a snack containing 20 g carbohydrate without insulin administration (stage III). The results of the blood sugar level during the 30th minute and during the fourth hour of the investigation are presented as per cent of the initial blood sugar level. Stage I ((10.1 mmol/l, SD = 5.2, 94%, SD = 54, 107%, SD = 50), stage II (9.16 mmol/l, SD = 5.1, 131%, SD = 86, 135%, SD = 97) and stage III (7.66 mmol/l, SD = 3.9, 189%, SD = 150, 153%, SD = 97). Processing of the results by Wilcoxon's test revealed a statistically significant difference of the blood sugar level after the load only between stages I and III (p < 0.01).
  
  
  CONCLUSIONS
  In type 1 diabetics treated by intensified insulin regimens the authors did not reveal a different response of the blood sugar level to loads on fasting or after a meal and insulin. Thus it is not necessary to respect previous recommendations: to take exercise 30-60 minutes after a meal, but according to individual needs of the patients.
authors.affiliation: I. interní klinika FN, Plzen.
authors.forename: Z
authors.initials: Z
authors.lastname: Rusavý
authors.forename: S
authors.initials: S
authors.lastname: Lacigová
authors.forename: V
authors.initials: V
authors.lastname: Srámek
authors.forename: I
authors.initials: I
authors.lastname: Novák
authors.forename: P
authors.initials: P
authors.lastname: Tĕsínský
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004435:Eating; D015444:Exercise; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin
vernacular_title: Casový vztah príjmu potravy, aplikace inzulinu a fyzické zátĕze u diabetiků I. typu lécených intenzifikovanými inzulinovými rezimy.