Partial characterization of a low molecular weight phagocytosis inhibitory factor obtained from human erythrocyte membranes.
Phagocytosis Inhibitory Factor (PIF), a small (< 3000 D) molecule, was partially purified from human red blood cell membranes. This factor inhibits latex phagocytosis by monocytic cells. PIF is not toxic under the experimental conditions employed and the phagocytosis inhibitory activity is reversible since removal of this factor restores the phagocytic capability of cells. The phagocytic activity of murine macrophages was not affected by PIF.
Baranyi
L
L
Department of Molecular Biology, Nagoya City University School of Medicine, Japan.
Baranji
K
K
Yoshida
T
T
Okada
N
N
Okada
H
H
D000818:Animals; D001798:Blood Proteins / Q000302:isolation & purification* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D004910:Erythrocyte Membrane / Q000737:chemistry*; D006801:Humans; D007840:Latex; D008565:Membrane Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D008970:Molecular Weight; D010587:Phagocytosis / Q000187:drug effects; D014407:Tumor Cells, Cultured
D001798:Blood Proteins; D007840:Latex; D008565:Membrane Proteins; C088638:phagocytosis-inhibitory factor