The effect of spironolactone on the rat uterus.
Our experimental study showed that in a dose related manner SP has successful inhibitory effect on the rat uterine horn, and also on the smooth muscle organs; ileum and trachea. We guess that SP can be used in well regulated dosed with least side effects to arrest preterm labor on human being in the future. Up to date there is no manuscript about contraction inhibitory effect of SP on the uterus. We hope this study will be of scientific help.
Coksevim
B
B
Department of Physiology, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.
Tayyar
M
M
D000818:Animals; D004054:Diethylstilbestrol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007556:Isoxsuprine / Q000008:administration & dosage / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012312:Ritodrine / Q000008:administration & dosage / Q000494:pharmacology; D013148:Spironolactone / Q000008:administration & dosage / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects; D014590:Uterine Contraction / Q000187:drug effects*
D013148:Spironolactone; D004054:Diethylstilbestrol; D012312:Ritodrine; D007556:Isoxsuprine