Functional analysis of the promoter of the Saccharomyces cerevisiae multidrug resistance gene YDR1, which encodes a member of the ATP binding cassette (ABC) superfamily.
The Saccharomyces cerevisiae gene YDR1/PDR5/STS1, which encodes a member of the ATP binding cassette (ABC) superfamily, is important for cross-resistance to apparently unrelated drugs. The expression of YDR1 is induced by various drugs and heat shock [Hirata et al., Curr. Genet., 26, 285-294 (1994)]. By deletion analysis of the 5'-noncoding region of the YDR1 gene, two drug responsive regions (-604 to -485 and -335 to -275) were identified with fluphenazine and cycloheximide. Three conserved palindrome sequences were found in these regions.
Miyahara
K
K
Department of Fermentation Technology, Hiroshima University, Japan.
Hirata
D
D
Miyakawa
T
T
D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D015152:Blotting, Northern; D002462:Cell Membrane / Q000378:metabolism; D018432:Drug Resistance, Multiple / Q000235:genetics*; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D008970:Molecular Weight; D011401:Promoter Regions, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics
D018528:ATP-Binding Cassette Transporters; D008565:Membrane Proteins