title: [Chronic obstructive bronchopneumonia (COBP), a precancerous state through destabilization of body homeostasis and bioenergetics].
abstract: Out of a number of 2113 of COLD ambulatory cases followed-up over 20 years, 170 cases of death were registered. The causes were: heart in 54%, cancer in 42% among which 37% lung cancer, exceeding 8 times the mean figures on the whole country. These diseases: COLD, atherosclerosis inducing heart disease and lung cancer have common risk factors which unbalance respiratory homeostasis. By obstructing the airways they lead to cellular O2 deficit. In this way the cell is compelled to shift to anaerobic glycolysis in order to supply the bioenergy necessary for life, resulting in malignancy mutagenesis. On a control group of 166 cases of lung cancer a ventilatory impairment was noted in the history: obstructive syndrome in 63.8%, restrictive syndrome in 28.3%, which means chronic respiratory insufficiency.
authors.affiliation: Institutul de Pneumoftiziologie Marius Nasta, Bucureşti.
authors.forename: H
authors.initials: H
authors.lastname: Morgenstern
authors.lastname: St Duţu
authors.forename: C
authors.initials: C
authors.lastname: Anastasatu
mesh_terms: D001996:Bronchopneumonia / Q000150:complications* / Q000378:metabolism / Q000401:mortality; D002283:Carcinoma, Bronchogenic / Q000209:etiology* / Q000378:metabolism; D002423:Cause of Death; D002908:Chronic Disease; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000378:metabolism; D011230:Precancerous Conditions / Q000209:etiology* / Q000378:metabolism; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology
vernacular_title: Bronhopneumopatia obstructivă cronică (BPOC), stare precanceroasă prin destabilizarea homeostaziei şi bioenergiei organismului.