title: The role of calcium homeostasis and calcium currents in ethanol actions on central mammalian neurons.
abstract: The ubiquitous role of calcium in ethanol actions measured electrophysiologically in central neurons is discussed. Acute ethanol administration to rat hippocampal neurons in vitro causes a hyperpolarization, increased AHPs, increased EPSPs and IPSPs, decreased modelled electronic interneuronal coupling, decreased high threshold Ca2+ currents, increased Ik, and increased synaptic GABAA currents. Alcohol withdrawal reverses some of these actions. Ca2+ is implicated in all of the above ethanol mediated effects.
authors.affiliation: Department of Medicine (Neurology), University of Toronto, Canada.
authors.forename: P L
authors.initials: PL
authors.lastname: Carlen
authors.forename: S S
authors.initials: SS
authors.lastname: Jahromi
authors.forename: T A
authors.initials: TA
authors.lastname: Valiante
authors.forename: A A
authors.initials: AA
authors.lastname: Velumian
authors.forename: J L
authors.initials: JL
authors.lastname: Weiner
authors.forename: L
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004594:Electrophysiology; D000431:Ethanol / Q000633:toxicity*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D006706:Homeostasis; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D015221:Potassium Channels; D011963:Receptors, GABA-A; D000431:Ethanol; D002118:Calcium