Isolation of antifungal and larvicidal constituents of Diplolophium buchanani by centrifugal partition chromatography.
Three phenylpropanoids, myristicin [1], elemicin [2], and trans-isoelemicin [3], together with two furanocoumarins, oxypeucedanin [4] and oxypeucedanin hydrate [5], have been isolated from the leaves of Diplolophium buchanani by a separation strategy involving the almost exclusive use of centrifugal partition chromatography. All five compounds were antifungal in a tlc bioautography test using Cladosporium cucumerinum. Compounds 1-4 exhibited larvicidal activity against Aedes aegypti.
Marston
A
A
Institut de Pharmacognoise et Phytochimie, Université de Lausanne, Switzerland.
Hostettmann
K
K
Msonthi
J D
JD
D000330:Aedes; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002845:Chromatography / Q000379:methods; D002850:Chromatography, Gel; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification*; D007814:Larva; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*
D000935:Antifungal Agents; D007306:Insecticides