title: Successful treatment of chronic necrotizing pulmonary aspergillosis with intracavitary instillation of amphotericin B--a case report.
abstract: We present an unusual case of 30-year-old man who was admitted to our hospital with dysesthesia of the limbs and skin eruptions. Polyarteritis nodosa was diagnosed based on the histopathological examination of sural nerve and renal biopsies. A month after initiation of corticosteroid therapy, a small infiltrative shadow was detected in the right mid-lung field by chest X-ray. Aspergillus infection was suspected based on a culture of bronchial lavage fluid. Despite intravenous administration of the antifungal agents, miconazole and fluconazole, a thin-walled cavity with a fungus ball gradually formed in the infiltrative lesion. The patient's clinicopathological findings were consistent with a diagnosis of chronic necrotizing pulmonary aspergillosis, a rare aspergillus infection in the lung. Treatment with intracavitary instillation of amphotericin B proved effective.
authors.affiliation: Department of Internal Medicine, Kyushu Koseinenkin Hospital, Kitakyushu.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: A
authors.initials: A
authors.lastname: Komori
authors.forename: N
authors.initials: N
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Ohsima
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Ninomiya
authors.forename: N
authors.initials: N
authors.lastname: Hara
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology; D002908:Chronic Disease; D006801:Humans; D016867:Immunocompromised Host; D007322:Instillation, Drug; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009336:Necrosis; D010488:Polyarteritis Nodosa / Q000150:complications; D011239:Prednisolone / Q000009:adverse effects
chemical_list: D000666:Amphotericin B; D011239:Prednisolone