title: Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature.
abstract: Lymphocytic adenohypophysitis can cause pituitary expansion and hypopituitarism closely mimicking the features of a pituitary adenoma. Discrimination between these two conditions is of importance since, despite the similarity of their presentation, there are significant differences in pathophysiology. In contrast to pituitary adenoma, lymphocytic adenohypophysitis occurs almost exclusively in young women in relation to pregnancy, there is a preference for destruction of ACTH and TSH secreting cells and computed tomographic scanning shows uniform contrast enhancement in a proportion of cases. There is, as yet, no proven specific non-surgical treatment. There are anecdotal reports of a beneficial effect of steroids but there is also evidence that spontaneous resolution may occur. We have reviewed the literature and report two new cases of lymphocytic adenohypophysitis both of whom exhibited early striking diffuse homogeneous contrast enhancement on magnetic resonance imaging scanning which we suggest may be a diagnostic feature of this condition.
authors.affiliation: Division of Medicine, United Medical School of Guy's Hospital, London, UK.
authors.forename: J K
authors.initials: JK
authors.lastname: Powrie
authors.forename: M
authors.initials: M
authors.lastname: Powell
authors.forename: A B
authors.initials: AB
authors.lastname: Ayers
authors.forename: C
authors.initials: C
authors.lastname: Lowy
authors.forename: P H
authors.initials: PH
authors.lastname: Sönksen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008279:Magnetic Resonance Imaging; D010900:Pituitary Diseases / Q000276:immunology* / Q000601:surgery; D010903:Pituitary Gland, Anterior / Q000276:immunology* / Q000601:surgery; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*