title: Interleukin-4 inhibits the expression of tumour necrosis factors alpha and beta, interleukins-1 beta and -6 and interferon-gamma.
abstract: T cell-derived IL-4 inhibits the expression of several inflammatory cytokine genes. In this study, IL-4 downregulated TNF-alpha and -beta, IL-1 beta IL-6 and IFN-gamma steady-state mRNA and protein production by blood leukocytes. In a detailed kinetic analysis, cytokine mRNA levels were significantly decreased in the presence of IL-4, suggesting an early and prolonged downregulatory effect. These findings support the general thesis that IL-4 is an important regulator of the inflammatory immune response.
authors.affiliation: Department of Surgery, Jonnson Comprehensive Cancer Center, UCLA School of Medicine 90024, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Rhoades
authors.forename: J S
authors.initials: JS
authors.lastname: Economou
mesh_terms: D016207:Cytokines / Q000096:biosynthesis*; D015536:Down-Regulation / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000276:immunology*; D015850:Interleukin-6 / Q000096:biosynthesis; D008233:Lymphotoxin-alpha / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D008233:Lymphotoxin-alpha; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007371:Interferon-gamma