Protection of goats against peste des petits ruminants with recombinant capripoxviruses expressing the fusion and haemagglutinin protein genes of rinderpest virus.
Goats were protected against a lethal challenge of peste des petits ruminants (PPR) virus following vaccination with a recombinant capripoxvirus containing either the fusion (F) gene of rinderpest virus or the haemagglutinin (H) gene of rinderpest virus. The H gene recombinant produced high titres of neutralizing antibody to rinderpest virus in the vaccinated goats, whereas the F gene recombinant failed to stimulate detectable levels of neutralizing antibody. A similar response to the two recombinant vaccines has previously been reported for cattle. Neither recombinant produced detectable levels of specific antibodies to PPR virus.
Romero
C H
CH
BBSRC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK.
Barrett
T
T
Kitching
R P
RP
Bostock
C
C
Black
D N
DN
D000818:Animals; D018151:Capripoxvirus / Q000235:genetics*; D003001:Cloning, Molecular; D005814:Genes, Viral; D005822:Genetic Vectors; D015511:Goat Diseases / Q000517:prevention & control*; D006041:Goats; D006388:Hemagglutinins / Q000235:genetics; D018185:Morbillivirus Infections / Q000517:prevention & control / Q000662:veterinary*; D018107:Peste-des-petits-ruminants virus / Q000276:immunology*; D012302:Rinderpest virus / Q000235:genetics; D014614:Vaccines, Synthetic / Q000627:therapeutic use*; D014764:Viral Proteins / Q000235:genetics; D014765:Viral Vaccines / Q000627:therapeutic use*
D006388:Hemagglutinins; D014614:Vaccines, Synthetic; D014764:Viral Proteins; D014765:Viral Vaccines