title: Terpenoids from Salvia sclarea.
abstract: From an acetone extract of the whole plant Salvia sclarea, seven known diterpenes, sclareol, manool, salvipisone, ferruginol, microstegiol, candidissiol and 7-oxoroyleanone, and two new ones, 2,3-dehydrosalvipisone and 7-oxoferruginol-18-al, as well as two sesquiterpenes, caryophyllene oxide and spathulenol, alpha-amyrin, beta-sitosterol and the flavonoids apigenin, luteolin, 4'-methylapigenin, 6-hydroxyluteolin-6, 7,3',4'-tetramethyl ether, 6-hydroxy apigenin-7,4'-dimethyl ether were obtained. The diterpenoids and the sesquiterpenoids were tested for antimicrobial activity against standard bacterial strains and a yeast. 2,3-Dehydrosalvipisone, sclareol, manool, 7-oxoroyleanone, spathulenol and caryophyllene oxide were found to be active against Staphylococcus aureus, the first and third compound against Candida albicans and the last compound against Proteus mirabilis.
authors.affiliation: Faculty of Pharmacy, University of Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ulubelen
authors.forename: G
authors.initials: G
authors.lastname: Topcu
authors.forename: C
authors.initials: C
authors.lastname: Eriş
authors.forename: U
authors.initials: U
authors.lastname: Sönmez
authors.forename: M
authors.initials: M
authors.lastname: Kartal
authors.forename: S
authors.initials: S
authors.lastname: Kurucu
authors.forename: C
authors.initials: C
authors.lastname: Bozok-Johansson
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D013729:Terpenes