Endothelin-induced activation of Cl- channels of guinea pig parietal cells.
The addition of endothelin-1 to the bath solution dose-dependently increased the whole-cell Cl- currents in single parietal cells isolated from guinea pig stomach. NPPB dose-dependently inhibited the current. Endothelin-3 was also effective, though less than endothelin-1.
Kajita
H
H
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Shirakata
Y
Y
Kotera
T
T
Ueda
S
S
Okada
Y
Y
D000818:Animals; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000187:drug effects*; D016232:Endothelins / Q000494:pharmacology*; D006168:Guinea Pigs; D009579:Nitrobenzoates / Q000494:pharmacology; D010295:Parietal Cells, Gastric; D018408:Patch-Clamp Techniques
D018118:Chloride Channels; D016232:Endothelins; D009579:Nitrobenzoates; C058176:5-nitro-2-(3-phenylpropylamino)benzoic acid