Humoral and cell-mediated immune responses in healthy children after one or two doses of varicella vaccine.
This study compared the immune responses of healthy children to one or two doses of Oka/Merck varicella vaccine. Both cell-mediated and humoral immune responses were significantly stronger 1 year later among children given two doses 3 months apart than among those given a single dose. Long-term follow-up studies are needed to determine whether two doses of vaccine indeed provide more complete and more durable protection than a single dose against breakthrough varicella in healthy children.
Watson
B
B
Division of Allergy, Immunology, and Infectious Diseases, Joseph Stokes, Jr., Research Institute, Philadelphia, Pennsylvania, USA.
Boardman
C
C
Laufer
D
D
Piercy
S
S
Tustin
N
N
Olaleye
D
D
Cnaan
A
A
Starr
S E
SE
D000914:Antibodies, Viral / Q000096:biosynthesis*; D002644:Chickenpox / Q000276:immunology* / Q000517:prevention & control; D019433:Chickenpox Vaccine; D002648:Child; D002675:Child, Preschool; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007115:Immunization Schedule; D007223:Infant; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D014613:Vaccines, Attenuated; D014765:Viral Vaccines