title: Gene transfer into human hemopoietic progenitor cells.
abstract: Considerable progress is being made in the transfer of genetic material to hematopoietic stem cells. In this chapter we describe how gene transfer is being used to: mark marrow and peripheral blood progenitor cells prior to autologous transplantation, to track their fate on reinfusion and to detect contaminating tumorigenic cells; modulate immunocyte function--important in immunologic disorders and perhaps in cancer therapy; generate tumor vaccines from tumor cells isolated from marrow; correct single gene defects--the 'classical' concept of gene therapy; and finally to modify the drug sensitivity of progenitor cells--enabling them to resist the suppressive effects of cytotoxic drugs during cancer therapy and perhaps providing a mechanism for in vivo selection of gene modified cells.
authors.affiliation: Division of Bone Marrow Transplantation, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Brenner
authors.forename: J M
authors.initials: JM
authors.lastname: Cunningham
authors.forename: B P
authors.initials: BP
authors.lastname: Sorrentino
authors.forename: H E
authors.initials: HE
authors.lastname: Heslop
mesh_terms: D000818:Animals; D004351:Drug Resistance / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005914:Globins / Q000235:genetics; D006412:Hematopoietic Stem Cells; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D014182:Transplantation, Autologous; D014777:Virus Diseases / Q000628:therapy
chemical_list: D005914:Globins