[Treatment of Still disease in adults with intravenous immunoglobulins].
In most cases, the treatment of adult's Still disease presents difficulties, in view of its undesirable side-effects. For this reason, we made an open trial of the effects of high-dose intravenous immunoglobulins (IVIg), a therapy with low iatrogen risk, and whose effectiveness in the treatment of other multisystemic diseases has been acknowledged. Seven patients suffering from adult Still's disease were given between one and eight IVIg infusions with a dose of 1 g/kg/day for two consecutive days. All seven responded positively, with clinical improvement. It lasted between 1 and 90 days in three patients, who subsequently relapsed; it has been continuing for an average of 13 months (2 to 24 months) in the other four patients. There were no clinical features making it possible to distinguish, after the trial, the patients who responded positively to intravenous immunoglobulins. This data, which needs to be confirmed with a controlled trial, provides hope of improved therapy for the one half of patients suffering from adult Still's disease who respond positively to intravenous immunoglobulins.
Permal
S
S
Service de médecine interne, hôpital Saint-Antoine, Paris, France.
Wechsler
B
B
Cabane
J
J
Perrot
S
S
Blum
L
L
Imbert
J C
JC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001799:Blood Sedimentation; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D016706:Still's Disease, Adult-Onset / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors
D016756:Immunoglobulins, Intravenous; D005293:Ferritins
Traitement de la maladie de Still de l'adulte par immunoglobulines intraveineuses.