Metabolic approach for regulation of IL-1 beta in vivo.
IL-1 beta, the autoantibodies to IL-1 beta and IL-1 beta-containing immune complex in pleural effusion and cerebrospinal fluid were detected using anti-recombinant human IL-1 beta monoclonal antibody. The results indicate that IL-1 beta is detectable in some cases, and the amounts decrease gradually with the chemotherapy following the autoantibodies and the specific detectable immune complex. These autoantibodies may have a feedback effect, inhibiting the IL-1 beta activity, and forming the immune complex to speed the clearance of activated IL-1 beta.
Yang
T
T
General Hospital of Beijing Military Region, China.
Zhu
X
X
Shen
B
B
Xu
W
W
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D006429:Hemiplegia / Q000134:cerebrospinal fluid; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis* / Q000276:immunology; D053583:Interleukin-1beta; D007938:Leukemia / Q000134:cerebrospinal fluid; D017254:Leukemic Infiltration; D008578:Meninges / Q000473:pathology; D010446:Peptide Fragments / Q000032:analysis* / Q000276:immunology; D010996:Pleural Effusion / Q000737:chemistry*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; C052994:interleukin-1beta (163-171)