A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.
Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.
Pérez de Castro
I
I
Departamento de Biología, Universidad Autonóma de Madrid, Spain.
Santos
J
J
Torres
P
P
Visedo
G
G
Saiz-Ruiz
J
J
Llinares
C
C
Fernández-Piqueras
J
J
D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D013030:Spain; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D005819:Genetic Markers; D017448:Receptors, Dopamine D2; D014446:Tyrosine 3-Monooxygenase