title: Trabeculectomy in pseudophakic patients: postoperative 5-fluorouracil versus intraoperative mitomycin C antiproliferative therapy.
abstract: Trabeculectomy outcome in pseudophakic glaucoma patients treated with mitomycin C (MMC) or 5-fluorouracil (5-FU) was analyzed retrospectively in 46 cases (46 eyes). Thirty patients received intraoperative MMC; 16, 5-FU. There were no significant differences between the two groups in terms of preoperative data (demographics, number of previous filtering procedures, visual acuity, and intraocular pressure [IOP]). After a mean follow up of 13.4 +/- 8.1 and 11.5 +/- 5.8 months for the 5-FU and MMC groups, respectively, 12 5-FU eyes (75%) and 21 MMC eyes (70%) were deemed at least qualified successes (IOP < or = 21 mm Hg with or without antiglaucoma medications). Six (37.5%) of the 5-FU eyes and 13 (43.3%) of the MMC eyes were complete successes (IOP < or = 21 mm Hg without antiglaucoma medications). There were no significant differences between the two groups in terms of duration of follow up, number of qualified successes, and number of complete successes (P = .35, .9, and .7, respectively). Nor were there any significant differences in the mean final IOPs and visual acuities. Excluding transient corneal effects associated with 5-FU therapy, there were no significant differences in the frequency of postoperative complications. These results suggest that 5-FU and MMC antiproliferative therapy are associated with similar short-term success rates and postoperative complications.
authors.affiliation: Department of Ophthalmology, University of Southern California School of Medicine, Doheny Eye Institute, Los Angeles 90033, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Prata Júnior
authors.forename: D S
authors.initials: DS
authors.lastname: Minckler
authors.forename: G
authors.initials: G
authors.lastname: Baerveldt
authors.forename: P P
authors.initials: PP
authors.lastname: Lee
authors.forename: L
authors.initials: L
authors.lastname: LaBree
authors.forename: D K
authors.initials: DK
authors.lastname: Heuer
mesh_terms: D000368:Aged; D002386:Cataract / Q000150:complications*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure; D007430:Intraoperative Care; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D011182:Postoperative Care; D012189:Retrospective Studies; D014130:Trabeculectomy; D014792:Visual Acuity
chemical_list: D016685:Mitomycin; D005472:Fluorouracil