title: [Danazol in the treatment of patients with combined pathology of endometrium and myometrium].
abstract: Forty-three patients aged 18 to 52 with combined diseases of the uterus and abnormal uterine bleedings were examined and followed up. The patients were prescribed danazon in a dose of 400 mg/day for 6 months to induce a short-term drug pseudomenopause. Immediate (in the cycle of drug discontinuation) and late (6 months after therapy discontinuation) results were assessed. A stable positive effect was observed in 12 women of premenopausal age over the course of 12-month follow-up; 10 patients were operated on for a recurrence of uterine bleedings and growth of uterine myomas. The mechanism of danazon effect on the female reproductive system and prospects of its use in diseases of the endo- and myometrium are discussed.
authors.forename: E M
authors.initials: EM
authors.lastname: Vikhliaeva
authors.forename: E V
authors.initials: EV
authors.lastname: Uvarova
authors.forename: I G
authors.initials: IG
authors.lastname: Ishchenko
mesh_terms: D000293:Adolescent; D000328:Adult; D003613:Danazol / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004717:Endometrium; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009215:Myometrium; D012008:Recurrence; D014591:Uterine Diseases / Q000188:drug therapy*; D014592:Uterine Hemorrhage / Q000188:drug therapy*
chemical_list: D003613:Danazol
vernacular_title: Opyt primeneniia danazola u bolńykh s sochetannoĭ patologieĭ éndo- i miometriia.