Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues.
An interdisciplinary (X-ray, 1H and 13C NMR, IR, and theoretical quantum mechanical) study on the potent 5-HT1A receptor ligand buspirone (1) and its two structural analogues, mesmar (4,4-dimethyl-1-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-2,6- piperidinedione) (2) and kaspar (8-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane - 7,9-dione) (3), has been reported. The results have shown that buspirone-like molecules should appear in an extended rod-shape form, possessing several potential interaction sites with the receptor.
Chilmonczyk
Z
Z
Pharmaceutical Research Institute, Warszawa, Poland.
Leś
A
A
Woźniakowska
A
A
Cybulski
J
J
Kozioł
A E
AE
Gdaniec
M
M
D002065:Buspirone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D002247:Carbon Isotopes; D002412:Cations; D004563:Electrochemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry / Q000378:metabolism*; D011522:Protons; D011985:Receptors, Serotonin / Q000378:metabolism*
D002247:Carbon Isotopes; D002412:Cations; D008024:Ligands; D010879:Piperazines; D011522:Protons; D011985:Receptors, Serotonin; C093620:kaspar; C093619:mesmar; D002065:Buspirone