Increased beta 2-microglobulin in both parotid and submandibular/sublingual saliva from patients with Sjögren's syndrome.
Samples of unstimulated saliva from patients with sialoadenopathy were collected by microcapillary tube (1 microliter), and their beta 2-microglobulin (B2-MG) content determined by a sandwich enzyme immunoassay. A higher than normal (control) concentration of the globulin was present in both parotid and submandibular/sublingual saliva from the patients with Sjögren's syndrome but not in the samples from the patients with sialoadenitis or diabetes mellitus. The increase in B2-MG in saliva from patients with Sjögren's syndrome may reflect that immunolopathological events are important in the degeneration of both glands in this disease. Therefore, the determination of B2-MG in saliva may be a simple, non-invasive technique for confirming the diagnosis of Sjögren's syndrome as an autoimmune disease.
Mogi
M
M
Department of Oral Biochemistry, Matsumoto Dental College, Nagano, Japan.
Kage
T
T
Chino
T
T
Yoshitake
K
K
Harada
M
M
D001327:Autoimmune Diseases / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000378:metabolism; D010309:Parotitis / Q000378:metabolism; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D012793:Sialadenitis / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000276:immunology / Q000378:metabolism*; D013361:Sublingual Gland / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000032:analysis*
D012471:Salivary Proteins and Peptides; D001613:beta 2-Microglobulin