Effects of lorazepam on human contrast sensitivity.
The anxiolytic lorazepam was studied for its effects on contrast sensitivity to gratings flickering in counterphase in normal volunteers. The drug significantly reduced contrast sensitivity at low spatial frequencies in a dose-related manner. The results are discussed with reference to possible GABA-mediated processes in the retina and lateral geniculate nucleus.
Haris
J P
JP
Department of Psychology, University of Reading, Earley Gate, Whiteknights, UK.
Phillipson
O T
OT
D000328:Adult; D015350:Contrast Sensitivity / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D010465:Perception / Q000187:drug effects; D011601:Psychophysics; D012684:Sensory Thresholds / Q000187:drug effects
D008140:Lorazepam