title: Remotely related sequences and structures: analysis and predictive modelling.
abstract: Through the comprehensive analysis of protein sequence and structural data, relationships can be established that suggest, with varying degrees of success, structural models for a protein for which only the sequence is known. The certainty with which a model can be proposed depends on the degree of similarity between the sequence of unknown structure and the sequence of a protein of known structure. Methods are being developed to detect remote similarities between sequences or structures, and to predict protein structure based on such small levels of similarity.
authors.affiliation: Laboratory of Mathematical Biology, National Institute for Medical Research, London, UK.
authors.forename: W R
authors.initials: WR
authors.lastname: Taylor
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid