[Inducible cyclooxygenase. New relationships between non-steroidal anti-inflammatory agents and inhibition of synthesis of prostaglandins].
After a brief history of the main discoveries concerning the research on arachidonic acid and its biologically active derivatives, recent findings related to the identification of 2 isoenzymes of the prostaglandin-H synthase (PGHS) are reviewed. These isoenzymes play different roles within the body, since PGHS-1 is involved in homeostasis when PGHS-2 is mainly expressed during the inflammatory reaction. Non-steroidal anti-inflammatory drugs classically inhibit the biosynthesis of prostaglandins but this inhibitory effect depends on the considered isoenzyme. This discovery may have pharmacological and clinical impact but, at the present time, research is focused more on new pharmacological targets than on improving drug prescription.
Terlain
B
B
Laboratoire de Pharmacologie et URA CNRS 1288, Faculté de Médecine de Nancy.
Jouzeau
J Y
JY
Gillet
P
P
Lecompte
T
T
Netter
P
P
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism*; D003864:Depression, Chemical; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007527:Isoenzymes; D011453:Prostaglandins; D016718:Arachidonic Acid; D011451:Prostaglandin-Endoperoxide Synthases
Cyclooxygénase inductible. Du nouveau sur les relations entre anti-inflammatoires non stéroïdiens et inhibition de la synthèse des prostaglandines.