Wound healing considerations in chemotherapy and radiation therapy.
Adjunctive radiation and chemotherapy have evolved to increase the survival rates and disease-free intervals that can be accomplished with surgical resection. We have reviewed the salient effects these agents have on wound healing. Further investigations into the specific wound-healing deficits caused by these agents and the development of interventional therapies will enable us to manipulate the wound milieu in order to accomplish the goal of oncologic cytoreductive therapy without detrimental effects on wound healing.
Drake
D B
DB
Department of Surgery, University of Kentucky Chandler Medical Center, Lexington, USA.
Oishi
S N
SN
D001918:Brachytherapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D006801:Humans; D009369:Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D011182:Postoperative Care; D011300:Preoperative Care; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*