The joint, a redox sensitive microenvironment?--an hypothesis.
Antioxidant depletion in a normal adult increases the risk of developing rheumatoid arthritis (1). We discuss how redox processes "control" the inflammatory reaction and suggest that the synovium is a peculiarly "redox-sensitive" microenvironment. This discussion will be illustrated by a zonal model of tissue injury to represent the diseased synovium.
Sahinoglu
T
T
London Hospital Medical College, U.K.
Stevens
C R
CR
Blake
D R
DR
D000818:Animals; D001168:Arthritis / Q000503:physiopathology; D006801:Humans; D007596:Joints / Q000378:metabolism* / Q000503:physiopathology; D008954:Models, Biological; D010084:Oxidation-Reduction; D013583:Synovial Membrane / Q000378:metabolism* / Q000503:physiopathology