The role of calcium homeostasis and calcium currents in ethanol actions on central mammalian neurons.
The ubiquitous role of calcium in ethanol actions measured electrophysiologically in central neurons is discussed. Acute ethanol administration to rat hippocampal neurons in vitro causes a hyperpolarization, increased AHPs, increased EPSPs and IPSPs, decreased modelled electronic interneuronal coupling, decreased high threshold Ca2+ currents, increased Ik, and increased synaptic GABAA currents. Alcohol withdrawal reverses some of these actions. Ca2+ is implicated in all of the above ethanol mediated effects.
Carlen
P L
PL
Department of Medicine (Neurology), University of Toronto, Canada.
Jahromi
S S
SS
Valiante
T A
TA
Velumian
A A
AA
Weiner
J L
JL
Zhang
L
L
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004594:Electrophysiology; D000431:Ethanol / Q000633:toxicity*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D006706:Homeostasis; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
D015221:Potassium Channels; D011963:Receptors, GABA-A; D000431:Ethanol; D002118:Calcium