Herpesvirus-like DNA sequences in non-Kaposi's sarcoma skin lesions of transplant patients.
Herpesvirus-like DNA sequences (KSHV) have been reported to be associated with various forms of Kaposi's sarcoma (KS). To determine if KSHV was associated with other proliferative skin lesions from non-AIDS immunocompromised patients, 33 skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrhoeic keratosis) from 4 organ-transplant patients receiving immunosuppressive therapy were tested for KSHV by PCR. KSHV sequences were detected in 82% of these skin lesions. Our results suggest that KSHV is associated with lesions other than KS in non-AIDS immunocompromised patients, and may also be involved in the pathogenesis of the various forms of proliferative skin lesions from organ-transplant patients.
Rady
P L
PL
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555-1019, USA.
Yen
A
A
Rollefson
J L
JL
Orengo
I
I
Bruce
S
S
Hughes
T K
TK
Tyring
S K
SK
D001483:Base Sequence; D002280:Basal Cell Carcinoma / Q000235:genetics / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000821:virology; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics*; D012628:Dermatitis, Seborrheic / Q000235:genetics / Q000821:virology; D015967:Gene Expression Regulation, Viral; D005914:Globins / Q000032:analysis / Q000235:genetics; D006564:Herpesviridae / Q000235:genetics*; D006801:Humans; D016867:Immunocompromised Host; D007642:Keratosis / Q000235:genetics / Q000821:virology; D016377:Organ Transplantation; D016133:Polymerase Chain Reaction; D012514:Sarcoma, Kaposi / Q000235:genetics / Q000821:virology; D012871:Skin Diseases / Q000235:genetics / Q000821:virology*; D012878:Skin Neoplasms / Q000235:genetics / Q000821:virology*; D014860:Warts / Q000235:genetics / Q000821:virology
D004279:DNA, Viral; D005914:Globins