title: Gastric cancer with bone marrow invasion at presentation: case-report and review of the literature.
abstract: A case of extensive bone marrow infiltration due to gastric cancer is reported. A 65-year old man with an acute episode of anemia (Hb 4.1 mg/dl) and dyspnea was admitted to the Medical Department of a general hospital. Bone marrow biopsy showed extensive paratrabecular infiltration of a poorly differentiated adenocarcinoma of gastric origin. The primary tumor in the stomach was confirmed, and the patient was referred to our Institute and treated with combination chemotherapy (FAMTX) for 6 cycles. Due to the disappearance of bone marrow infiltration, the patient was considered for curative resection of the primary gastric cancer. After 27 months the patient is alive and in clinical complete remission.
authors.affiliation: Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Crivellari
authors.forename: A
authors.initials: A
authors.lastname: Carbone
authors.forename: R
authors.initials: R
authors.lastname: Sigon
authors.forename: A
authors.initials: A
authors.lastname: Buonadonna
authors.forename: R
authors.initials: R
authors.lastname: Cannizzaro
authors.forename: R
authors.initials: R
authors.lastname: Sorio
authors.forename: C
authors.initials: C
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Monfardini
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D004317:Doxorubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D004317:Doxorubicin; D005472:Fluorouracil; D008727:Methotrexate