Glial responses to hypoxic/ischemic encephalopathy in neonatal rat cerebrum.
This study was undertaken to examine glial responses in the immature rat brain to hypoxic/ischemic injury. The results indicate that developing microglia are the first and principle glial element that responds to hypoxic/ischemic injury during the neonatal period. The astrocyte response occurs later and macrophage infiltration may be delayed or absent.
Ohno
M
M
Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
Aotani
H
H
Shimada
M
M
D000818:Animals; D001253:Astrocytes / Q000276:immunology / Q000502:physiology*; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000276:immunology; D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007511:Ischemia / Q000473:pathology*; D017628:Microglia / Q000276:immunology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley