title: [Cardiotoxicity of 5-fluorouracil: a question of formulation].
abstract: The cardiotoxicity of 5-fluorouracil (FU) was attributed to degradation compounds present in the injected vials, fluoroacetaldehyde (Facet) and fluoromalonaldehydic acid (FMald). These compounds are formed with time in the basic medium necessary to solubilize FU. FU-NaOH vials were much less cardiotoxic than FU-Tris vials on the isolated perfused rabbit heart model since, in FU-Tris vials, Facet and FMald are stored in stable "depot" forms, which are adducts with Tris, whereas, in FU-NaOH vials, they are extensively chemically transformed. Cardiotoxic fluoroacetate (FAC), arising from Facet metabolization, was found in urine of patients, with a ratio FAC/FU catabolites 10-30 fold lower in patients treated with FU-NaOH than in those treated with FU-Tris.
authors.affiliation: Laboratoire des IMRCP (URA CNRS 470), université Paul-Sabatier, Toulouse, France.
authors.forename: L
authors.initials: L
authors.lastname: Lemaire
authors.forename: M
authors.initials: M
authors.lastname: Arellano
authors.forename: M C
authors.initials: MC
authors.lastname: Malet-Martino
authors.forename: R
authors.initials: R
authors.lastname: Martino
authors.forename: M
authors.initials: M
authors.lastname: De Forni
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005472:Fluorouracil / Q000009:adverse effects*; D006331:Heart Diseases / Q000139:chemically induced*; D011817:Rabbits; D012307:Risk Factors; D012995:Solubility
chemical_list: D005472:Fluorouracil
vernacular_title: Cardiotoxicité du 5-fluorouracile: une question de formulation.