Modulation of the electrical differentiation of neurons by interactions with glia and other non-neuronal cells.
Glial cells have long been recognized as participating in development of neural tissue by providing a scaffolding for migration and by synthesis and secretion of a variety of growth factors and extracellular matrix components. An additional role for glia and other non-neuronal cells in the electrical differentiation of neurons has been suggested by several recent articles, in particular a group that has focused on the potassium currents that influence action potential repolarization and repetitive activity. In this review I present examples of developmental regulation of potassium currents by interactions with non-neuronal cells and discuss some implications of this regulation.
Barish
M E
ME
Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA.
D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D002642:Chick Embryo; D002645:Chickens; D005314:Embryonic and Fetal Development; D006624:Hippocampus / Q000502:physiology; D051379:Mice; D009420:Nervous System / Q000166:cytology / Q000196:embryology; D009424:Nervous System Physiological Phenomena; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000502:physiology; D015221:Potassium Channels / Q000096:biosynthesis / Q000502:physiology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology
D015221:Potassium Channels