Maternal age and oral cleft malformations: data from a population-based series of 576,815 consecutive livebirths.
It has been suggested that older mothers are more likely to have a child with isolated cleft palate (CP) or cleft lip +/- cleft palate (CL +/- CP), but most of these studies have been based on fairly small sample sizes. Data from a population-based registry with multiple sources of case ascertainment were used to examine any association of maternal age with the incidence of these defects in infants without other congenital anomalies. The study group consisted of all cases with CP or CL +/- CP without other congenital anomalies from a series of over half a million consecutive livebirths during the period 1966 to 1981 inclusive in British Columbia. During the study period, the overall incidences of isolated CP and isolated CL +/- CP per 10,000 livebirths were 3.9 and 8.2, respectively. No association with maternal age was found when either isolated CP or isolated CL +/- CP was analyzed as a group. When analyzed by sex, and by CP or CL +/- CP, no significant maternal-age effect was observed for males and females with CP or CL +/- CP. Our population-based data, therefore, do not show that older mothers are more likely to have a child with cleft palate, or cleft lip +/- cleft palate.
Baird
P A
PA
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Sadovnick
A D
AD
Yee
I M
IM
D001955:British Columbia / Q000453:epidemiology; D002971:Cleft Lip / Q000453:epidemiology* / Q000209:etiology; D002972:Cleft Palate / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008297:Male; D008423:Maternal Age; D018566:Pregnancy, High-Risk; D012042:Registries