Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate.
Clofibrate, a potent peroxisomal proliferator, increased the concentration of pivaloylcarnitine (nmol/g) in rat liver (mean +/- S.D.) from 11 +/- 1 (controls) to 213 +/- 39 (clofibrate), in heart from 348 +/- 107 to 521 +/- 41 and in brown adipose tissue from 185 +/- 52 to 184 +/- 39 after administration of sodium pivalate. Clofibrate feeding increased the activity of carnitine acetyltransferase (U/mg) in liver (mean +/- S.D.) from 0.02 +/- 0.00 to 0.41 +/- 0.07 and decreased the triacylglycerol concentration (mg/g liver, mean +/- S.D.) from 33.53 +/- 4.53 to 11.03 +/- 0.71.
Diep
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Medical Department, Aker University Hospital, Oslo, Norway.
Bøhmer
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D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002331:Carnitine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D002332:Carnitine O-Acetyltransferase / Q000096:biosynthesis; D002994:Clofibrate / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010421:Pentanoic Acids / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000032:analysis
D010421:Pentanoic Acids; D014280:Triglycerides; C005566:pivalic acid; C054040:pivaloylcarnitine; D002332:Carnitine O-Acetyltransferase; D002994:Clofibrate; D002331:Carnitine