Severe halogen acne due to a trifluoromethylpyrazole derivative and its resistance to isotretinoin.
We report a case of severe chloracne, with systemic involvement, following occupational exposure to dihydrotrifluoromethylphenyl benzothiopyranopyrazolone, which, to our knowledge, has not been previously reported as a cause of chloracne. Aggressive drug treatment, including high-dose oral isotretinoin was of limited benefit in suppressing the disease activity.
Scerri
L
L
Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, U.K.
Zaki
I
I
Millard
L G
LG
D000152:Acne Vulgaris / Q000139:chemically induced* / Q000473:pathology; D004345:Drug Industry; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*; D011720:Pyrazoles / Q000009:adverse effects*; D047069:Pyrazolones
D006845:Hydrocarbons, Fluorinated; D011720:Pyrazoles; D047069:Pyrazolones; C093782:dihydrotrifluoromethylbenzothiopyranopyrazolone