title: The barrier function in neodymium-YAG laser capsulotomy.
abstract: BACKGROUND
  Complications following neodymium (Nd)-YAG laser capsulotomy have been attributed to damage to the capsule and vitreous face.
  
  
  OBJECTIVE
  To measure the disruption of the anterior-posterior extracapsular barrier complex induced by Nd-YAG laser capsulotomy and to determine how it might be minimized, using a fluorophotometer.
  
  
  METHODS
  Prospective study of 21 eyes undergoing Nd-YAG laser capsulotomy and cross-sectional comparison with 15 pseudophakic eyes with clear capsules.
  
  
  METHODS
  University-based clinical practice.
  
  
  METHODS
  Neodymium-YAG laser posterior capsulotomy per study protocol.
  
  
  METHODS
  Change in extracapsular barrier efficiency as measured by fluorophotometry.
  
  
  RESULTS
  Multivariate regression demonstrated that both anterior vitreous disruption and absence of a posterior chamber intraocular lens (aphakia) were significantly correlated with loss of barrier efficiency, whereas capsulotomy size was not. The anterior vitreous was judged to be undamaged in 67% of eyes treated by the study protocol. However, all myopic eyes sustained damage. Opacification of the posterior capsule itself was also associated with mild loss of barrier function even before capsulotomy, compared with the clear-capsule group. Glaucoma occurred more frequently when barrier efficiency was lost postoperatively.
  
  
  CONCLUSIONS
  Damage to the extracapsular barrier complex by Nd-YAG laser capsulotomy is minimized when the anterior vitreous is preserved. The study treatment protocol may be useful in limiting this damage and in reducing complications.
authors.affiliation: Edward S. Harkness Eye Institute, Columbia Presbyterian Medical Center, New York, NY, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Smith
authors.forename: W E
authors.initials: WE
authors.lastname: Moscoso
authors.forename: S
authors.initials: S
authors.lastname: Trokel
authors.forename: J
authors.initials: J
authors.lastname: Auran
mesh_terms: D001082:Aqueous Humor / Q000378:metabolism; D002387:Cataract Extraction; D019793:Fluorescein; D005452:Fluoresceins / Q000493:pharmacokinetics; D015590:Fluorophotometry; D006801:Humans; D053685:Laser Therapy; D007903:Lens Capsule, Crystalline / Q000502:physiology / Q000601:surgery*; D007910:Lenses, Intraocular; D015999:Multivariate Analysis; D011446:Prospective Studies; D014822:Vitreous Body / Q000378:metabolism / Q000502:physiology*
chemical_list: D005452:Fluoresceins; D019793:Fluorescein