Efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on osteosarcoma growth and lung metastasis in rats.
The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. Male Fischer 344 rats bearing the tumor with a high potential for metastasis received intermittent or continuous subcutaneous administrations of AGM-1470. Both treatment regimens resulted in significant inhibitions of spontaneous lung metastasis and primary tumor growth in a dose-dependent manner, with continuous administration of AGM-1470 exerting the most pronounced inhibitory effects on both parameters.
Morishita
T
T
Department of Orthopedic Surgery, Nara Medical University, Kashihara.
Mii
Y
Y
Miyauchi
Y
Y
Miura
S
S
Honoki
K
K
Aoki
M
M
Kido
A
A
Tamai
S
S
Tsutsumi
M
M
Konishi
Y
Y
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D003510:Cyclohexanes; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007279:Injections, Subcutaneous; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008297:Male; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D012516:Osteosarcoma / Q000188:drug therapy*; D051381:Rats; D011916:Rats, Inbred F344; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D003510:Cyclohexanes; D012717:Sesquiterpenes; D000077609:O-(Chloroacetylcarbamoyl)fumagillol