[Protein phosphorylation and activity of insulin and epidermal growth factor receptors in liver plasma membranes of rats kept in the zone of the accident at the Chernobyl nuclear power station].
Disruption in transfer of regulatory signal from insulin and EGF receptors in liver plasma membrane of rats, their 3 generation being kept in the Chernobyl accident 30-km zone has been found. As in case with imbalance in hormone binding and receptor phosphorylation of insulin receptors in experimental diabetes mellitus, an increasing of insulin and EGF binding by appropriate receptors with simultaneous decrease of its protein kinase activity after ligand binding was shown in rats chronically irradiated in the 30-km accident zone.
Bozhok
O V
OV
BezdrobnyĭIuV
Kulik
G O
GO
Serkiz
Ia I
IaI
Kartel'
A A
AA
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D004781:Environmental Exposure; D066246:ErbB Receptors / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011210:Power Plants; D011494:Protein Kinases / Q000378:metabolism; D018788:Radioactive Hazard Release; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism*; D014455:Ukraine
D008565:Membrane Proteins; D011494:Protein Kinases; D066246:ErbB Receptors; D011972:Receptor, Insulin
Fosforyliuvannia bilkiv i aktyvnist' retseptoriv insulinu ta epidermal'noho faktora rostu u plazmatychnykh membranakh pechinky shchuriv za umov zony vidchuzhdennia ChAES.