Clinical isolate of a Xanthomonas maltophilia strain producing L-1-deficient and L-2-inducible beta-lactamases.
Xanthomonas maltophilia produces two inducible beta-lactamases, L-1 and L-2, and resists the antimicrobial activity of beta-lactam antibiotics including carbapenems. L-1 has carbapenemase activity and L-2 is a cephalosporinase. It has been suggested that these beta-lactamases share regulatory components. We isolated a recent clinical X. maltophilia strain susceptible to carbapenems and resistant to almost all the other beta-lactam antibiotics tested. beta-Lactamase induction with cefotaxime showed that the clinical isolate had low-level expression of L-1 beta-lactamase but remained inducible for L-2 enzyme. The possible relationship of this enzyme to carbapenem sensitivity is considered.
Bonfiglio
G
G
Istituto di Microbiologia Medica, Università di Catania, Italy.
Stefani
S
S
Nicoletti
G
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002510:Cephalosporinase / Q000096:biosynthesis*; D004790:Enzyme Induction; D006801:Humans; D008826:Microbial Sensitivity Tests; D010405:Penicillinase / Q000096:biosynthesis* / Q000172:deficiency; D013045:Species Specificity; D014974:Xanthomonas / Q000145:classification / Q000201:enzymology* / Q000302:isolation & purification; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D002510:Cephalosporinase; D010405:Penicillinase