title: A comparison of nucleotide sequences of measles virus L genes derived from wild-type viruses and SSPE brain tissues.
abstract: The nucleotide sequences of the large protein (L) gene derived from two wild-type measles viruses (MV) and two SSPE brain-derived viruses have been determined. All sequences have single large open reading frames encoding 2183 amino acid residues. The deduced L proteins are well conserved and the proposed functional domains which have been identified for rhabdo- and paramyxoviruses are completely conserved in all strains. The degree of variability of L proteins is the lowest of all structural proteins of MV, reflecting its role in virus reproduction and persistence. Biased hypermutation was not observed in the L genes derived from SSPE brain tissue. None of the nucleotide changes can be associated with the attenuated phenotype of the Edmonston vaccine viruses.
authors.affiliation: Institute of Virology, University of Würzburg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Komase
authors.forename: B K
authors.initials: BK
authors.lastname: Rima
authors.forename: I
authors.initials: I
authors.lastname: Pardowitz
authors.forename: C
authors.initials: C
authors.lastname: Kunz
authors.forename: M A
authors.initials: MA
authors.lastname: Billeter
authors.forename: V
authors.initials: V
authors.lastname: ter Meulen
authors.forename: K
authors.initials: K
authors.lastname: Baczko
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001921:Brain / Q000821:virology*; D002648:Child; D003001:Cloning, Molecular; D005260:Female; D005814:Genes, Viral / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008458:Measles Vaccine / Q000235:genetics; D008459:Measles virus / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D010802:Phylogeny; D013190:SSPE Virus / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013344:Subacute Sclerosing Panencephalitis / Q000821:virology; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D008458:Measles Vaccine; D015678:Viral Structural Proteins