title: Comparison of technetium-99m methoxyisobutylisonitrile and gallium-67 citrate scanning in the assessment of lymphomas.
abstract: The aim of this study was to compare the value of scintigraphy using technetium-99m methoxyisobutylisonitrile (MIBI) with that of scintigraphy using gallium-67 citrate in the assessment of Hodgkin's disease and non-Hodgkin's lymphoma and to relate these results with those of CT scan and MRI. Fifty-eight patients were included either for a follow-up examination or for monitoring of their treatment. Twenty-three residual masses were studied. A whole-body scan was performed, followed by single-photon emission computed tomography (SPET) 20 min after injection of 740 MBq of 99mTc-MIBI and 72 h after injection of 185 MBq of 67Ga citrate. The overall sensitivity of 99mTc-MIBI and 67Ga citrate was 71% and 68%, respectively, and the overall specificity was 76% and 44%, respectively. For residual masses, the sensitivity was 44% with both tracers and the specificity was 80% with 99mTc-MIBI and 53% with 67Ga citrate. The positive predictive values were 85% and 68% and the negative predictive values were 59% and 44%, respectively. The signal-to-background ratio was 1.5 for 99mTc-MIBI and 2 for 67Ga citrate. At present, 99mTc-MIBI cannot replace 67Ga citrate in the assessment of lymphomas.
authors.affiliation: Service Associé de Médecine Nucléaire, Hôpital Cl. Huriez, Chu de Lille, France.
authors.forename: P
authors.initials: P
authors.lastname: Ziegels
authors.forename: M
authors.initials: M
authors.lastname: Nocaudie
authors.forename: D
authors.initials: D
authors.lastname: Huglo
authors.forename: M
authors.initials: M
authors.lastname: Deveaux
authors.forename: L
authors.initials: L
authors.lastname: Detourmignies
authors.forename: E
authors.initials: E
authors.lastname: Wattel
authors.forename: X
authors.initials: X
authors.lastname: Marchandise
mesh_terms: D000328:Adult; D001706:Biopsy; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes; D006689:Hodgkin Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D019343:Citric Acid; D017256:Technetium Tc 99m Sestamibi