[Changes in the content and fractional composition of blood plasma nucleic acids in radiation lesions. The effect of radioprotectors].
The content of DNA in blood plasma increased in early stages after irradiation (2 and 5 h), the low-molecular DNA (160-180 bp) being revealed as opposed to intact animals. Protection of gamma-irradiated rats by cystamine or gammaphos enhanced this phenomenon. The injections of cystamine and gammaphos to nonirradiated animals stimulated DNA ejection into blood stream in 2 h only with normalization by 5 h. Cystamine was the most effective, and in experiment with non-irradiated animals the low-molecular DNA was detected for cystamine only.
Sherlina
S S
SS
Belokhvostov
A S
AS
Lebedev
S N
SN
Antushevich
A E
AE
D004999:Amifostine / Q000627:therapeutic use; D000818:Animals; D003538:Cystamine / Q000627:therapeutic use; D004247:DNA / Q000097:blood / Q000187:drug effects* / Q000528:radiation effects*; D004353:Drug Evaluation, Preclinical; D004587:Electrophoresis, Agar Gel; D008297:Male; D008970:Molecular Weight; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D013050:Spectrometry, Fluorescence; D013997:Time Factors; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D004247:DNA; D004999:Amifostine; D003538:Cystamine
Izmenenie soderzhaniia i fraktsionnogo sostava nukleinovykh kislot plazmy krovi pri radiatsionnykh porazheniiakh. Effekt radioprotektorov.