[The importance of stereoselectivity for the effectiveness and safety of drugs].
Forty per cent of synthetic drugs are chiral, most of them being used in the form of a racemate. Though the existence of optical isomerism has been known since the last century, an increased attention to pharmacological and toxicological differences in the individual enantiomers of chiral drugs is being paid as late as the recent two decades. The present review paper discusses the importance of stereoselectivity and on the examples of the individual drugs it lists the advantages and/or disadvantages of the individual isomers with regard to the racemic mixture from the standpoint of efficacy and safety.
Králiková
D
D
Farmakologický ústav Lekárskej fakulty Univerzity Komenského, Bratislava.
Bozeková
L
L
Brandsteterová
E
E
Kriska
M
M
D002626:Chemistry, Pharmaceutical; D013237:Stereoisomerism
Význam stereoselektivity pre úcinnost a bezpecnost lieku.