Characterization of fibrinogen-binding properties of Actinomyces pyogenes.
This study was designed to further characterize the fibrinogen-binding properties of Actinomyces pyogenes. The fibrinogen-binding capacities of a selected A. pyogenes culture could be significantly enhanced by heat pretreatment (60 degrees C, 1 h) of the bacteria. The fibrinogen-binding site seemed to be a protein which was specific for fibrinogen. In phagocytosis studies, binding of fibrinogen to A. pyogenes significantly increased the phagocytic capacity of bovine polymorphonuclear leucocytes.
Lämmler
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Institut für Bakteriologie und Immunologie, Justus-Liebig-Universität Giessen, Germany.
Ding
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D000190:Actinomyces / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D005340:Fibrinogen / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D008854:Microscopy, Electron; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis
D005340:Fibrinogen