title: Localized T2 measurements using an OSIRIS-CPMG method. Application to measurements of blood oxygenation and transverse relaxation free of diffusion effect.
abstract: This work presents a new method allowing localized T2 measurements, based upon the OSIRIS scheme. A train of 180 degrees pulses is applied after the OSIRIS preparation cycle, recording directly the transverse magnetization decay. The method was verified for two nuclei, 1H and 19F, with phantoms and in vivo on rats. The accuracy of the T2 values is discussed, as well as possible applications of the OSIRIS-CPMG method to proton transverse spin relaxation measurements, free of diffusion effects, and to non-invasive in vivo blood oxygenation measurements, through the use of an emulsion of perfluorooctylbromide, a blood substitute containing fluorine.
authors.affiliation: Fondation pour la Recherche en Neurosciences Appliquées à la Psychiatrie, Rouffach, France.
authors.forename: F
authors.initials: F
authors.lastname: Girard
authors.forename: P
authors.initials: P
authors.lastname: Poulet
authors.forename: I J
authors.initials: IJ
authors.lastname: Namer
authors.forename: J
authors.initials: J
authors.lastname: Steibel
authors.forename: J
authors.initials: J
authors.lastname: Chambron
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D004058:Diffusion; D005260:Female; D005461:Fluorine; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D010100:Oxygen / Q000097:blood*; D011522:Protons; D051381:Rats; D011917:Rats, Inbred Lew; D013696:Temperature
chemical_list: D011522:Protons; D005461:Fluorine; D010100:Oxygen