[The protective effect of monoclonal anti-idiotypic antibodies in experimental herpes infection].
The protective effect of monoclonal anti-idiotypic antibodies m(anti-ID)Abs, simulating the biologic effects of human alpha interferons, were studied in male guinea pigs with genital herpes simplex. Therapeutic effect of m(anti-ID)Abs daily applied as liquid dosage form and as suppositories+ was assessed. Experiments demonstrated that m(anti-ID)Abs in liquid dosage form to a different measure decreased the severity of urogenital infection in guinea pigs and that m(anti-ID)Abs-25 completely prevented the development of grave infection.
Nagieva
F G
FG
Barkova
E P
EP
Nikulina
V G
VG
Krasnova
N I
NI
Andzhaparidze
O G
OG
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002460:Cell Line; D002522:Chlorocebus aethiops; D006224:Cricetinae; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000517:prevention & control*; D007167:Immunotherapy; D008297:Male; D014709:Vero Cells
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal
Protektivnyĭ éffekt monoklonal'nykh antiidiotipicheskikh antitel pri éksperimental'noĭ gerpeticheskoĭ infektsii.