title: Probable disseminated cerebral aspergillosis: recovery with medical treatment.
abstract: Cerebral aspergillosis has a very poor prognosis. When this complication occurs in the immunocompromised host, evolution is virtually fatal in all cases despite surgical and medical treatment. We describe in this report the case of a child with acute lymphoblastic leukaemia who developed pulmonary aspergillosis, and subsequent cerebral dissemination during therapeutic induction. Due to multifocal cerebral lesions, surgery was impossible. The patient was administered long term treatment including amphotericin B, flucytosine and itraconazole for 9 months, during which time a neutropenic period occurred with reactivation of cerebral mycotic lesions, in spite of modification of antileukaemic therapy. Seven years later, he nevertheless remains in complete remission without any neurological sequelae. Thus cerebral aspergillosis requires early diagnosis and can be treated using a strong combination of antimycotic drugs (amphotericin B, flucytosine and itraconazole) on a long term basis, even when aspergillomas cannot be removed surgically. Antileukaemic therapy must be concomitantly adapted to avoid or limit neutropenia.
authors.affiliation: Unité d'Hémato-Oncologie Pédiatrique, Hôpital de la Mère et de l'Enfant, CHU de Nantes, France.
authors.forename: H
authors.initials: H
authors.lastname: Avet-Loiseau
authors.forename: F
authors.initials: F
authors.lastname: Mechinaud-Lacroix
authors.forename: J Y
authors.initials: JY
authors.lastname: Cohen
authors.forename: J L
authors.initials: JL
authors.lastname: Harousseau
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy*; D001927:Brain Diseases / Q000188:drug therapy*; D002648:Child; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*
chemical_list: D017964:Itraconazole; D000666:Amphotericin B; D005437:Flucytosine