Assessment of myocardial viability in chronic left ventricular dysfunction.
Differentiation of infarcted from viable myocardium is of critical clinical importance in patients with severely impaired left ventricular function. While positron emission tomography is considered the "gold-standard" modality for detection of viable myocardium, expense has limited its more widespread use. Therefore, many centers employ surrogate tests for metabolic viability. In several recent studies, low-dose dobutamine echocardiography has been useful in predicting recovery of poorly contractile myocardium. Myocardial contrast echocardiography is a promising new technique which may predict viability by defining areas of preserved microvascular integrity. The clinical role of these diagnostic modalities in the setting of depressed ventricular function is as yet uncertain. Clarification of the utility of these tests should allow more judicious selection of patients who would derive the greatest survival benefit from revascularization procedures.
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Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
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Pellikka
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D002908:Chronic Disease; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004280:Dobutamine; D004452:Echocardiography; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D017682:Myocardial Stunning / Q000175:diagnosis / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D005996:Nitroglycerin; D013794:Thallium Radioisotopes; D014022:Tissue Survival; D014055:Tomography, Emission-Computed; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000473:pathology
D005462:Fluorine Radioisotopes; D013794:Thallium Radioisotopes; D019788:Fluorodeoxyglucose F18; D004280:Dobutamine; D003847:Deoxyglucose; D005996:Nitroglycerin