[Dynamics of lipid peroxidation in blood and organs of rats after irradiation at low doses and the effect of antioxidants].
A study was made of the dynamics of lipid peroxidation (LPO) in rats after the whole-body 1.0 Gy X-irradiation (ten fractions of 0.1 Gy at a 24-hour interval; 0.425 R/min) and the possibility of correction LPO with alpha-tocopherylacetate, ascorbic acid and catechin complex by means of a single and combined administration. The accumulation of primary and secondary LPO products in blood, radiosensitive (spleen and mucosa of small intestine) and radioresistant (brain) organs is established. The administration of mentioned antioxidants diminishes the content LPO products, but does not completely normalize the latter. Administration of antioxidant complex was most effective.
Baraboĭ
V A
VA
Oliĭnyk
S A
SA
Blium
I O
IO
Korniĭchuk
H M
HM
Khmielievs'kyĭ
Iu V
IuV
D000222:Adaptation, Physiological; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000528:radiation effects; D002462:Cell Membrane / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D007413:Intestinal Mucosa / Q000187:drug effects / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D009928:Organ Specificity; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D014916:Whole-Body Irradiation
D000975:Antioxidants; D010743:Phospholipids
Dynamika perekysovogo okisnennia lipidiv v krovi ta organakh shchuriv za oprominennia v niz'kykh dozakh ta efekt antyoksydantiv.