title: Glutathione peroxidase and glutathione reductase activities in cancerous and non-cancerous human kidney tissues.
abstract: Selenium-dependent (Se-GSH-Px), selenium-independent (non-Se-GSH-Px) glutathione peroxidase and glutathione reductase (GSSG-Rx) activities have been determined in cancerous and non-cancerous human adult kidney. Large inter-individual variation in the activities of all enzymes tested were found in both tumour and non-tumour specimens. In general a significant decrease in the activities of the three enzymes was found in tumours. When a comparison was made between cancerous and non-cancerous tissues of the same individual, Se-GSH-Px activity was found to be lower in tumour in 17 cases out of 29, and the non-Se-GSH-Px activity in 20. In 20 cases out of 29 GSSG-Rx was found to be lower in tumour. It was concluded that changes in the factors involved in the anti-oxidative protection actually occur in human kidney tumour.
authors.affiliation: Istituto di Scienze Biochimiche, Facoltà di Medicina, Università G. D'Annunzio, Chieti, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Di Ilio
authors.forename: P
authors.initials: P
authors.lastname: Sacchetta
authors.forename: S
authors.initials: S
authors.lastname: Angelucci
authors.forename: A
authors.initials: A
authors.lastname: Zezza
authors.forename: R
authors.initials: R
authors.lastname: Tenaglia
authors.forename: A
authors.initials: A
authors.lastname: Aceto
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000201:enzymology*; D007680:Kidney Neoplasms / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000494:pharmacology
chemical_list: D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D012643:Selenium