[An immunomorphological study of the effect of ionizing radiation on the nonlymphoid structures of the mouse thymus using monoclonal antibodies].
Expression of cytoskeleton components revealed with monoclonal antibodies was increased in epithelial cells of mouse thymus one day after total gamma-irradiation with doses of 0.5-4.0 Gy, while after the doses of 10 and 15 Gy it was decreased. The antigen expression was reversed to initial level 14 days after the dose of 4 Gy; thymocyte depletion was progressed and continuous massifs of epithelial cells was formed. The oval cysts and immunoglobulin deposits were appeared in thymus two months after irradiation with the dose of 4 Gy.
Kuz'menok
O I
OI
Beletskaia
L V
LV
Gnezditskaia
E V
EV
Iarilin
A A
AA
D000818:Animals; D000911:Antibodies, Monoclonal; D015551:Autoimmunity / Q000528:radiation effects; D003599:Cytoskeleton / Q000276:immunology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004848:Epithelium / Q000276:immunology / Q000473:pathology / Q000528:radiation effects; D016650:Fluorescein-5-isothiocyanate; D005720:Gamma Rays; D007136:Immunoglobulins / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008856:Microscopy, Fluorescence; D013950:Thymus Gland / Q000276:immunology* / Q000473:pathology / Q000528:radiation effects*; D013997:Time Factors
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D016650:Fluorescein-5-isothiocyanate
Immunomorfologicheskoe izuchenie vliianiia ioniziruiushcheĭ radiatsii na nelimfoidnye struktury timusa mysheĭ s pomoshch'iu monoklonal'nykh antitel.