Transplants to the cerebral cortex of nucleus basalis magnocellularis-lesioned rats: effects on deficits in latent inhibition.
Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ameliorate other lesion-induced cognitive deficits, we tested here whether expression of latent inhibition could be reinstated by graft placement. Interestingly, grafts of either chromaffin cells or cells from kidney or liver that have been used previously as control grafts, were able to restore latent inhibition in lesioned animals. These results suggest that it may be a host response to graft placement rather than a factor supplied by the grafted tissue itself that is responsible for the amelioration of lesion-induced deficits of latent inhibition.
Welner
S A
SA
Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Canada.
Rousse
I
I
Rochford
J
J
D000313:Adrenal Medulla / Q000637:transplantation*; D000818:Animals; D001288:Attention / Q000502:physiology; D001479:Basal Ganglia / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D008297:Male; D016318:Quisqualic Acid / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013216:Reflex, Startle / Q000502:physiology*
D016318:Quisqualic Acid