[The anticytolytic activity of ubiquinone-10 in a liver lesion from chlorinated hydrocarbons].
Antioxidative activity of ubiquinone-10, exceeding the level of that of vitamin E more than five times and anticytolytic activity of vitamin E and particularly of ubiquinone-10 manifested in decreasing activities of blood serum alanine aminotransferase and histidineammoniumlyase, which might be determined only during toxic liver damage, have been demonstrated. The activity of histidineammoniumlyase was considerably decreased under the effect of vitamin E and particularly in the presence of ubiquinone-10. Decreasing of activity of blood serum enzyme markers of cytolysis of hepatocytes is connected with the hepatocytes biomembrane stabilizing effect of antioxidants which was confirmed by the electron microscope investigation method. The evidence of safety of intact cellular and subcellular membranes and activation of compensative and regenerative processes in hepatocytes was also represented.
Vinogradova
L F
LF
Kharlitskaia
E V
EV
Mirzoian
Zh A
ZhA
Beketova
T P
TP
Burobina
S S
SS
D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D000871:Anthelmintics / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D006638:Histidine Ammonia-Lyase / Q000097:blood / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D014451:Ubiquinone / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use; D014992:Xylenes / Q000506:poisoning*
D000871:Anthelmintics; D000931:Antidotes; D014992:Xylenes; D014451:Ubiquinone; D014810:Vitamin E; C000294:hexachloro-4-xylene; D000410:Alanine Transaminase; D006638:Histidine Ammonia-Lyase; C025204:Ubiquinone Q2
Antitsitoliticheskaia aktivnost' ubikhinona-10 pri porazhenii pecheni khlorirovannymi uglevodorodami.