Analysis of ketorolac in postmortem blood.
This paper describes analytical methods using high-performance liquid chromatography and gas chromatography-mass spectrometry (GC-MS) for the isolation of the nonsteroidal anti-inflammatory drug, ketorolac. The drug is isolated from postmortem blood using a batched solid-phase extraction method on Amberlite XAD-2 resin. Derivatization of ketorolac using diazopropane was necessary prior to GC-MS analysis. The methods were applied in the investigation of a death occurring shortly after the administration of an intramuscular injection of ketorolac tromethamine. Death was attributed to an adverse reaction to the drug, resulting in anaphylaxis and cardiac arrest.
Logan
B K
BK
Washington State Toxicology Laboratory, Department of Laboratory Medicine, University of Washington, Seattle 98134, USA.
Friel
P N
PN
Peterson
K L
KL
Predmore
D B
DB
D000328:Adult; D000707:Anaphylaxis / Q000097:blood / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004342:Drug Hypersensitivity / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007273:Injections, Intramuscular; D020910:Ketorolac; D020911:Ketorolac Tromethamine; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning; D014325:Tromethamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000506:poisoning
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D014046:Tolmetin; D020910:Ketorolac