title: [The effect of bentazone TP, an herbicide, on hematologic indicators in sheep during acute and subchronic poisoning].
abstract: Hematological changes at poisoning with the bentazone herbicide manufactured by the Research Institute of Chemical Technology in Bratislava were investigated in sheep of the Slovak Merino breed. Acute intoxication in seven head of sheep was induced by a single application of bentazone with cannula at a sublethal dose of 1,450 mg/kg live weight. Bentazone was diluted with sunflower oil at a ratio 1:5. Subchronic intoxication was induced by an administration of bentazone in feed to the sheep for 84 days: a dose of 175 mg/kg live weight (1/10 of LD50) for the first experimental group (six head), and a dose of 97.5 mg/kg live weight (1/12 of LD50) for the second experimental group (six head). The control group did not receive any dietary bentazone. Acute intoxication with herbicide did not cause any statistically significant changes in hemoglobin, erythrocyte and leucocyte counts in the sheep within 120 hours after application. In comparison with the physiological standard, a slight increase in the percentage of neutrophils and a decrease in the lymphocyte percentage were observed. The values of eosinophils, basophils and monocytes remained unchanged. Observation of subchronic intoxication did not reveal any significant negative effect of the two doses of the herbicide within 84 days on the hematological parameters. Our experiments demonstrate that bentazone does not negatively influence blood formation.
authors.affiliation: University Veterinary Medicine, Kosice, Slovak Republic.
authors.forename: J
authors.initials: J
authors.lastname: Sály
authors.forename: P
authors.initials: P
authors.lastname: Kacmár
authors.forename: J
authors.initials: J
authors.lastname: Neuschl
authors.forename: J
authors.initials: J
authors.lastname: Jantosovic
mesh_terms: D000818:Animals; D001581:Benzothiadiazines / Q000506:poisoning*; D004906:Erythrocyte Count / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis; D006540:Herbicides / Q000506:poisoning*; D011041:Poisoning / Q000097:blood / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood* / Q000139:chemically induced
chemical_list: D001581:Benzothiadiazines; D006454:Hemoglobins; D006540:Herbicides; C002003:bentazone
vernacular_title: Vplyv herbicídu bentazón TP na hematologické ukazovatele u oviec v podmienkach akútnej a subchronickej intoxikácie.