Antibiotic kinetics and dynamics for the clinician.
In recent decades considerable data have been acquired concerning the complex interactions of the organism-antimicrobial-host triad. Using the current understanding of drug disposition in the body, pharmacokinetics, and in vitro microbiologic activity, optimal dosing strategies can be derived to maximize clinical efficacy and minimize potential toxicities. This article discusses pharmacokinetics, pharmadynamics, and the application of this principle in clinical practice.
Nicolau
D P
DP
Department of Pharmacy, Hartford Hospital, Connecticut, USA.
Quintiliani
R
R
Nightingale
C H
CH
D000465:Algorithms; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007239:Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D007260:Infusion Pumps; D008657:Metabolic Clearance Rate; D008826:Microbial Sensitivity Tests; D011485:Protein Binding; D015610:Serum Bactericidal Test; D013997:Time Factors
D000900:Anti-Bacterial Agents