title: Folliculitis decalvans and human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
abstract: Human T-cell lymphotropic virus type I (HTLV-I) can be associated with either adult T-cell leukemia or HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic progressive immune-mediated myelopathy. Skin manifestations such as xerosis and erythema may be associated with HAM/TSP. Infective dermatitis due to Staphylococcus aureus or beta-hemolytic Streptococcus has recently been described as a marker for HTLV-I infection and as a probable risk factor for the development of adult T-cell leukemia and lymphoma in Jamaican children. We report a case of folliculitis decalvans, a rare chronic follicular inflammatory process of bacterial origin that is extremely resistant to treatment, in a patient with HAM/TSP. This case suggests the possibility that the disturbance of the immune system that was observed in patients with HAM/TSP can play a role in the persistence of this severe skin lesion. In addition, the findings of our case cast doubt on the hypothesis that the cause of infective dermatitis in persons infected with HTLV-I is immunosuppression due to congenital or perinatal infection of the immature immune system.
authors.affiliation: HTLV-Associated Neuropathy Unit, Evandro Chagas Hospital, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil.
authors.forename: A Q
authors.initials: AQ
authors.lastname: Araújo
authors.forename: M J
authors.initials: MJ
authors.lastname: Andrada-Serpa
authors.forename: T A
authors.initials: TA
authors.lastname: Paulo-Filho
authors.forename: M T
authors.initials: MT
authors.lastname: Rodrigues
authors.forename: L A
authors.initials: LA
authors.lastname: Prado
mesh_terms: D000328:Adult; D001483:Base Sequence; D015342:DNA Probes; D005499:Folliculitis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D015493:Paraparesis, Tropical Spastic / Q000150:complications* / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
chemical_list: D015342:DNA Probes; D011241:Prednisone