[Target dose markers. Exposure indicators for environmental epidemiological studies].
It is of major importance to have good characterization of individual exposures in environmental epidemiological studies. Quantification of the dose at the site of action (target dose, biologically effective dose) gives the best correlation with health outcome. Target dose markers are indicators which have recently been applied in environmental epidemiological studies. Especially, measurements of adducts to macromolecules (DNA, protein) have been much used. The authors give an overview over available exposure markers, focusing on studies were target dose markers have been employed. It is important to be aware of the limitations associated with the use of such markers.
Dybing
E
E
Avdeling for miljømedisin Statens Institutt for Folkehelse, Oslo.
Alexander
J
J
D015415:Biomarkers / Q000032:analysis; D018736:DNA Adducts / Q000032:analysis; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D016273:Occupational Exposure
D015415:Biomarkers; D018736:DNA Adducts; D004785:Environmental Pollutants
Måldosemarkører. Eksponeringsindikatorer for miljøepidemiologiske undersøkelser.