Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis.
This article reviews published evidence describing the enzymatic and nonenzymatic formation and the routes of metabolism of the hepoxilins. Also treated are the major approaches used for the chemical synthesis of these compounds and for some of their analogs.
Pace-Asciak
C R
CR
Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Reynaud
D
D
Demin
P M
PM
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism; D000818:Animals; D004355:Drug Stability; D015289:Leukotrienes / Q000138:chemical synthesis / Q000378:metabolism*; D015394:Molecular Structure
D015289:Leukotrienes; C021201:12-HPETE; C022948:10-hydroxy-11,12-epoxyeicosa-5,8,14-trienoic acid; C038243:8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid; D015126:8,11,14-Eicosatrienoic Acid