title: Pattern of arterial aneurysms in acquired immunodeficiency disease.
abstract: The ever-spreading incidence of infection with the human immunodeficiency virus (HIV) has introduced a spectrum of unusual, subtle, and often life-threatening lesions that can affect almost every organ and tissue in the body. With the introduction of laboratory serologic evidence of HIV infection, the spectrum of indicator diseases has extended beyond the classic opportunistic infections and Kaposi sarcoma. An analysis of 28 patients in Zimbabwe with focal areas of vascular disease treated during a 4-year period (1989-1993) defined 16 patients ranging in age from 12 to 46 years appropriate for special scrutiny as they evinced none of the usual causes of vascular disease. Twelve of the patients were HIV-positive; in two patients the serologic status was unknown; and two patients were HIV-negative at the time of their presentation. There were special clinical features in this group of patients selected for study: (1) They were young with a mean age of 31 years; (2) they were all indigenous Africans with no evidence of atherosclerosis; and there was (3) rapid development of focal necrotizing vasculitis with aneurysm formation and rupture or (4) slow, progressive development of granulomatous vasculitis. The sites of cardiovascular involvement included the left ventricle; aortic arch; thoracic, thoracoabdominal, and abdominal aorta; and iliac, femoral, gluteal, popliteal, and subclavian arteries. It is inferred that the association between HIV-positive status and arterial aneurysms or fibroproliferative aortic occlusion are causally related and that the principles of vascular surgery can be successfully applied to their treatment.
authors.affiliation: Department of Cardiothoracic Surgery, Parirenyatwa Hospital, Borrowdale, Harare, Zimbabwe.
authors.forename: C
authors.initials: C
authors.lastname: Marks
authors.forename: S
authors.initials: S
authors.lastname: Kuskov
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000000981:diagnostic imaging* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000783:Aneurysm / Q000000981:diagnostic imaging* / Q000601:surgery; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000601:surgery; D000792:Angiography; D001158:Arteries / Q000601:surgery; D002648:Child; D015023:Democratic Republic of the Congo; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000000981:diagnostic imaging / Q000601:surgery