title: Leucoencephalomalacia and cerebral white matter vacuolar degeneration in two related Labrador retriever puppies.
abstract: Two Labrador Retriever dogs from a common dam had similar neurological deficits consisting of cortical blindness, dullness, and loss of previously learned habits. Both were examined at 5 months of age, and histopathological examination revealed leucoencephalomalacia and vacuolar degeneration of the cerebral white matter. Histopathologic findings in these 2 dogs differed from those reported previously in Labrador Retrievers with spongy degeneration of central nervous system white matter. A nonlittermate full sibling to 1 of these dogs was examined at 1.5 years of age for similar clinical signs that did not progress for the next 25 months.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Neer
authors.forename: J N
authors.initials: JN
authors.lastname: Kornegay
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D009410:Nerve Degeneration; D009474:Neurons / Q000473:pathology*; D014617:Vacuoles / Q000473:pathology*