In vitro and in vivo effects of somatostatin on the growth of A431 cells.
We previously reported that the octapeptide somatostatin (SS) analogue SMS 201-995 (SMS) unexpectedly stimulates the growth of A431 human epidermoid carcinoma cells in vitro. In the present study, we found that both SS-14 and SS-28 also stimulated the growth of A431 cells in vitro. The proliferative effect of SS-28 also stimulated the growth of A431 cells in vitro. The proliferative effect of SS-28 was greater than that of SS-14. In contrast, there was no difference in A431 cell tumor weight or area between the SMS-treated or untreated athymic, tumor-bearing mice. The serum epidermal growth factor (EGF) level of the SMS-treated mice was significantly lower than that of the untreated mice. Decreases in serum EGF may attenuate the proliferative effect of SMS in vivo.
Kamiya
Y
Y
Third Department of Internal Medicine, Nagoya City University Medical School, Japan.
Ito
J
J
Fujii
T
T
Horie
K
K
Kawaguchi
M
M
Hori
R
R
Sakuma
N
N
Fujinami
T
T
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000097:blood; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D013004:Somatostatin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D013004:Somatostatin; D004815:Epidermal Growth Factor