title: Effect of xylitol-containing chewing gum on sorbitol metabolism in dental plaque.
abstract: The aim of the present study was to examine whether a long-term use of chewing gum with xylitol as the only sweetener would affect sorbitol metabolism in dental plaque. Ten test subjects used xylitol-sweetened chewing gum for 12 weeks. Plaque was collected at three occasions; 1) Control plaque; 2) Test plaque I: plaque collected after 12 weeks of chewing xylitol-containing chewing gum; 3) Test plaque II: sucrose-stimulated plaque collected 2 d after Test plaque I was collected. Plaque suspensions were incubated with [14C]sorbitol, and uptake of sorbitol and production of sorbitol metabolites were determined by HPLC. Plaque formation and sorbitol uptake were significantly reduced.
authors.affiliation: Department of Oral Biology, Dental Faculty, University of Oslo, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Assev
authors.forename: G
authors.initials: G
authors.lastname: Rølla
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000328:Adult; D002638:Chewing Gum; D003773:Dental Plaque / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D013012:Sorbitol / Q000378:metabolism*; D014993:Xylitol / Q000494:pharmacology*
chemical_list: D002638:Chewing Gum; D013012:Sorbitol; D014993:Xylitol