Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera.
Six new and three synthetically known glycosides have been isolated from the leaves of Moringa oleifera, employing a bioassay-directed isolation method on the ethanolic extract. Most of these compounds, bearing thiocarbamate, carbamate or nitrile groups, are fully acetylated glycosides, which are very rare in nature. Elucidation of the structures was made using chemical and spectroscopic methods, including 2D NMR techniques. Thiocarbamates showed hypotensive activity.
Faizi
S
S
H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
Siddiqui
B S
BS
Saleem
R
R
Siddiqui
S
S
Aftab
K
K
Gilani
A H
AH
D000107:Acetylation; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000494:pharmacology; D002219:Carbamates / Q000737:chemistry* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D008969:Molecular Sequence Data; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013057:Spectrum Analysis
D000959:Antihypertensive Agents; D002219:Carbamates; D006027:Glycosides