Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase.
Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.
Lingham
R B
RB
Merck Research Laboratories, Rahway, NJ 07065.
Silverman
K C
KC
Bills
G F
GF
Cascales
C
C
Sanchez
M
M
Jenkins
R G
RG
Gartner
S E
SE
Martin
I
I
Diez
M T
MT
Peláez
F
F
D019883:Alkyl and Aryl Transferases; D005285:Fermentation; D008298:Maleates / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000378:metabolism*; D014166:Transferases / Q000037:antagonists & inhibitors*
D008298:Maleates; C080569:chaetomellic acid A; C085713:chaetomellic acid B; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase