[Paradoxical effects of thiol compounds].
Thiols act as universal antimutagens and their use is promising in the treatment of free radical diseases whose list is presented in the paper. Yet it is necessary to take into account the specific features of their action, including a paradoxical effects. The latter has different manifestations and causes: production of mutagenic products (H2O2, radicals of thiols, mutagenic conjunctives-derivatives with xenobiotics), which results in the maximum phenomenon-elimination of susceptible individuals and cells, carriers of mutations or mutant cells themselves; the allele saving effect and, presumably, the diverse action of thiols on the package of characteristics of free radical diseases. There are characteristics which enter the package, involving chromosomal instability; hypersensitivity to certain mutants; DNA repair defect or deficiency; abnormalities of the systems acting before DNA-mutagen interaction; deficiency of antimutagens; immunodeficiency; increased lipid peroxidation, production of clastogenic factor(s).
Ranchialis
V P
VP
Bal'chiunene
L S
LS
D016587:Antimutagenic Agents / Q000494:pharmacology / Q000627:therapeutic use; D004247:DNA / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair / Q000187:drug effects; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation; D016296:Mutagenesis / Q000187:drug effects; D009153:Mutagens; D013438:Sulfhydryl Compounds / Q000378:metabolism / Q000494:pharmacology*
D016587:Antimutagenic Agents; D005609:Free Radicals; D009153:Mutagens; D013438:Sulfhydryl Compounds; D004247:DNA
"Paradoksal'noe" deĭstvie tiolovykh soedineniĭ.