title: New programs for protein tertiary structure prediction.
abstract: Prediction of protein tertiary structure remains an unsolved problem in molecular biology, but a solution to this problem is extremely important for protein engineering and rational drug design. Recent developments in motif recognition and side chain modeling present the prospect of nearly automatic model building for a large fraction of newly determined protein sequences. We review some of these new algorithms and present preliminary results of their application to the prediction of a structure for fasciclin III, a neural adhesion molecule from Drosophila.
authors.affiliation: Department of Biological Sciences, University at Albany, SUNY 12222.
authors.forename: J S
authors.initials: JS
authors.lastname: Fetrow
authors.forename: S H
authors.initials: SH
authors.lastname: Bryant
mesh_terms: D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry; D004330:Drosophila / Q000737:chemistry; D029721:Drosophila Proteins; D015195:Drug Design; D008958:Models, Molecular; D015202:Protein Engineering; D017434:Protein Structure, Tertiary
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D029721:Drosophila Proteins; C061565:Fas3 protein, Drosophila