The DRD2 dopamine receptor and the candidate gene approach in alcoholism.
The cloning of the DRD2 dopamine receptor gene and discovery of an associated polymorphism permitted genetic association and linkage studies to alcoholism. Extensive allele frequency differences between populations provide an alternative explanation for explaining a DRD2 association to alcoholism which has been observed in some studies, but more frequently has not been replicated.
Goldman
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Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, DICBR, Bethesda, MD 20892, USA.
D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*
D017448:Receptors, Dopamine D2