Body composition and bone mineral density in untreated and treated patients with celiac disease.
Body composition and bone mineral density (BMD) were studied by X-ray absorptiometry in 20 untreated and 12 treated women with celiac disease, as well as in 85 age-matched control women. Untreated patients had a significantly lower body weight, fat mass, lean tissue mass and BMD at the lumbar spine and total skeleton compared to controls (p < 0.001 for all parameters). Treated patients had also a significantly lower body weight (p < 0.01) fat mass (p < 0.05) and bone mineral density at lumbar spine and total skeleton (p < 0.05) compared with controls, but lean tissue mass was not diminished. However, treated patients had a significantly higher body weight, fat mass and BMD of the total skeleton compared with untreated celiac patients (p < 0.01 for all parameters). Serum alkaline phosphatase levels were increased in untreated patients but serum 250HD was normal. In conclusion, celiac disease causes a global and almost universal reduction of fat mass and BMD. The results of this cross-sectional study suggest that osteopenia does not seem to be completely restored by adequate treatment. Alteration of vitamin D metabolism was not the cause of osteopenia in the majority of patients.
González
D
D
Sección Osteopatías Médicas, Hospital de Clínicas, Buenos Aires, Argentina.
Mazure
R
R
Mautalen
C
C
Vazquez
H
H
Bai
J
J
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001823:Body Composition / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000178:diet therapy / Q000209:etiology / Q000503:physiopathology; D001842:Bone and Bones / Q000502:physiology; D002112:Calcifediol / Q000097:blood; D002118:Calcium / Q000097:blood; D002446:Celiac Disease / Q000150:complications / Q000178:diet therapy / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae / Q000502:physiology; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011863:Radioimmunoassay; D012016:Reference Values
D015415:Biomarkers; D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D002112:Calcifediol; D002118:Calcium