[Autosensitization to myofibrillar proteins of myocardium in patients with different clinical forms of ischemic heart disease].
An indirect ELISA method has been used to study formation of autoantibodies (AA) to myocardial myofibrillar proteins in patients with different clinical IHD forms. Purified myosin (MS), actin (AC) and tropomyosin (TM) of the intact human myocardium acted as antigens. The highest level of AA to MS and AC was found in patients with AMI (acute myocardial infarct): it exceeded twice that of the norm and 1.5 times that in patients with IAP (instable angina pectoris). Moreover the AA level in IAP patients exceeded that of normal 1.5 times. In PC (postinfactional cardiosclerosis) patients the MS AA and AC AA tend to the norm. The TM AA contents in PC patients is 1.2 times higher than that in AMI and IAP patients, not differing from the norm in all patient groups. The role of autosensibilization to contrectile proteins in progress of IHD and development of AMI is discussed.
Kornilina
O M
OM
Dubrovska
G V
GV
Mkhitarian
L S
LS
Parkhomenko
O M
OM
Viatchenko
O V
OV
Rodnin
M V
MV
D000199:Actins / Q000378:metabolism*; D000787:Angina Pectoris / Q000378:metabolism*; D001161:Arteriosclerosis / Q000378:metabolism*; D001323:Autoantibodies / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism*; D009210:Myofibrils / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*; D014335:Tropomyosin / Q000378:metabolism*
D000199:Actins; D001323:Autoantibodies; D014335:Tropomyosin; D009218:Myosins
Autosensybilizatsiia do miofibryliarnykh bilkiv miokarda u khvorykh z riznymy klinichnymy formamy ishemichnoĭ khvoroby sertsia.