title: Follicular lymphoma adjacent to foreign body granulomatous inflammation and fibrosis surrounding silicone breast prosthesis.
abstract: Silicone lymphadenopathy has been associated with fracture and/or erosive breakdown of silastic implants in joint replacements and is also known to occur with cosmetic and reconstructive breast implant surgery. In the orthopedic literature rare malignant lymphomas have been reported in association with silicone granulomas in lymph nodes; whether silicone is a causative agent remains controversial. We report a single case of a 56-year-old woman who had painful capsular contractures and a 2-cm palpable nodule medial to her silicone mammary implant. Histologically the mass comprised an extra nodal follicular mixed lymphoma with surrounding granulomatous response to polarizable foreign body material. Paraffin immunophenotyping, bcl-2 protein staining, and gene rearrangement analysis verified this diagnosis.
authors.affiliation: College of Physicians and Surgeons, Columbia University, Department of Pathology, New York, New York 10032, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Cook
authors.forename: B M
authors.initials: BM
authors.lastname: Osborne
authors.forename: R L
authors.initials: RL
authors.lastname: Connor
authors.forename: J F
authors.initials: JF
authors.lastname: Strauss
mesh_terms: D018427:Breast Implants / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005355:Fibrosis / Q000473:pathology; D005549:Foreign-Body Reaction / Q000473:pathology*; D006801:Humans; D008224:Lymphoma, Follicular / Q000473:pathology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology; D012828:Silicones / Q000009:adverse effects*
chemical_list: D012828:Silicones