Blood and peritoneal levels of endothelin in continuous ambulatory peritoneal dialysis patients.
We have determined the plasma levels of endothelin-1 (ET-1) in patients with end-stage renal disease treated with continuous ambulatory peritoneal dialysis (CAPD). In 10 CAPD patients mean plasma ET levels (7.01 +/- 0.5 pg/ml) were found higher than in normal subjects (3.6 +/- 0.6 pg/ml). Peritoneal clearance of ET-1 was 1.58 +/- 0.12 ml/min and 2.3 +/- 0.2 ml/min during an isotonic peritoneal exchange and a hypertonic exchange, respectively. Plasma ET-1 levels decreased slightly but significantly during a hypertonic 4-hour exchange (from 7.01 +/- 0.5 to 6.14 +/- 0.4 pg/ml) (p < 0.05) and were not modified by an isotonic 4-hour exchange (from 5.7 +/- 0.5 to 6.4 +/- 0.4 pg/ml). ET-1 is known to be an important vascular stimulant and thus elevated ET-1 levels may play a role in the genesis of cardiovascular complications which are the leading cause of mortality in these patients.
Vlassopoulos
D
D
Department of Nephrology, Hôpital Pitié-Salpêtrière, Paris, France.
Deray
G
G
Carayon
A
A
Maistre
G
G
Jacobs
C
C
D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism*; D015314:Dialysis Solutions; D016232:Endothelins / Q000097:blood* / Q000378:metabolism*; D005260:Female; D006801:Humans; D006982:Hypertonic Solutions; D007552:Isotonic Solutions; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012016:Reference Values
D015314:Dialysis Solutions; D016232:Endothelins; D006982:Hypertonic Solutions; D007552:Isotonic Solutions