title: Effects of hypertonic-hyperoncotic infusion on the human atrial natriuretic factor in a standardized clinical trial.
abstract: Hypertonic-hyperoncotic solutions (HHT) are presently being utilized to resuscitate patients in shock. However, so far, the effects of HHT on human atrial natriuretic factor (hANF) have not yet been investigated in a clinical trial. The effects of HHT on hANF were studied in a standardized preoperative and clinical setting in patients undergoing aneurysmectomy. Twenty-three conscious patients were included in two groups: 11 HHT and 12 HES (HHT: 7.5% NaCl/10% HES 200; HES: .9% NaCl/10% HES 200). Stepwise infusion of 50 mL was titrated preoperatively according to individual Frank-Starling relationships. Central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP) were determined before, during and after volume application. hANF, cGMP were also measured before and 1, 10, 30, 60, and 120 min after administration. The volumes necessary to produce the same volume status were: 213.6 +/- 63.6 mL of HHT, 409.9 +/- 136.2 mL of HES (p < .001). The sodium load was 273.9 +/- 81.5 mmol of [HHT], 63.1 +/- 21.0 mmol of [HES] (p < .001).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Institute of Anesthesiology and Intensive Therapy, Klinikum der Stadt Mannheim, University of Heidelberg, Germany.
authors.forename: M D
authors.initials: MD
authors.lastname: Albrecht
authors.forename: M
authors.initials: M
authors.lastname: Schroth
authors.forename: M
authors.initials: M
authors.lastname: Fähnle
authors.forename: K
authors.initials: K
authors.lastname: Ellinger
mesh_terms: D000704:Analysis of Variance; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002496:Central Venous Pressure; D006152:Cyclic GMP / Q000097:blood; D004311:Double-Blind Method; D006801:Humans; D006982:Hypertonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010953:Plasma Volume; D011669:Pulmonary Wedge Pressure
chemical_list: D006982:Hypertonic Solutions; D007552:Isotonic Solutions; C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP