title: [Penicillin resistance of pneumococci from invasive pediatric infections].
abstract: Susceptibility to antibiotics of 199 isolates of Streptococcus pneumoniae from blood and cerebrospinal fluid of children hospitalized during 1987-1993 was tested. Of 119 isolates, 18% were resistant to penicillin. The prevalence in 1992-93 was double that in 1987-89. The increase in minimal inhibitory concentrations (MIC) of penicillin was associated with an increase in MIC of other beta-lactams. There was also resistance to other antibiotics: trimethoprim-sulfamethoxazole, erythromycin and chloramphenicol. Most of the resistant isolates belonged to serogroups 6, 14, 19 and 23. When planning vaccine policies, resistant types should be taken into consideration.
authors.affiliation: Pediatric Infectious Disease Unit, Soroka Medical Center, Beer Sheba.
authors.forename: A
authors.initials: A
authors.lastname: Goldbart
authors.forename: P
authors.initials: P
authors.lastname: Yagupsky
authors.forename: R
authors.initials: R
authors.lastname: Dagan
mesh_terms: D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006801:Humans; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification