The effects of 5-HT3 receptor antagonists in models of dependency and withdrawal.
Pharmacological manipulations to enhance 5-HT synthesis and release have been reported to reduce alcohol intake. However, recent evidence indicates that 5-HT3 receptor antagonists may also exert a similar effect in a number of species. This report reviews the existing data which implicates a central role for 5-HT3 receptors in the control of psychoactive substance abuse.
Costall
B
B
School of Pharmacy, University of Bradford, West Yorkshire, U.K.
Domeney
A M
AM
Kelly
M E
ME
Naylor
R J
RJ
D000428:Alcohol Drinking / Q000188:drug therapy; D000437:Alcoholism / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D012702:Serotonin Antagonists; D000431:Ethanol