Steroidal saponins from the bulbs of Lilium regale and L. henryi.
Two new and three known steroidal saponins were isolated from the fresh bulbs of Lilium regale and two known saponins from those of L. henryi. The structures of the new saponins were established by extensive spectral data, hydrolysis and chemical correlation as (25R)-27-O-[(S)-3-hydroxy-3-methylglutaroyl]-spirost-5 -ene-3 beta,27-diol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-glucopyranosyl-(1-->3)]- beta-D-glucopyranoside and (25S)-spirost-5-ene-3 beta,17 alpha,27-triol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-glucopyranosyl-(1-->2)-O- beta-D-glucopyranosyl-(1-->4)]-beta-D-glucopyranoside. Inhibitory activity of the saponins on cyclic AMP phosphodiesterase was evaluated.
Mimaki
Y
Y
Tokyo College of Pharmacy, Japan.
Sashida
Y
Y
Nakamura
O
O
Nikaido
T
T
Ohmoto
T
T
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D002240:Carbohydrate Sequence; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D010840:Phytosterols; D012503:Saponins; D015105:3',5'-Cyclic-AMP Phosphodiesterases