Anti-oral microbial activity of isoflavonoids in root bark of Ormosia monosperma.
From the root bark of Ormosia monosperma, 10 isoflavonoids including two new compounds 7,4'-dihydroxy-6",6"-dimethylpyrano-(2",3":5,6)-8-(3-methyl-1,3- butadienyl)isoflavone, named ormosidin, and dalbergion 4'-O-beta-D-glucopyranoside, were isolated. These structures were confirmed by spectroscopic analysis. 2,3-Dihydroauriculatin, one of the compounds isolated, showed moderate activities against oral-microbial organisms (Streptococcus mutans, Prophyromonas gingivalis and Actinomyces actinomycetemcomitans).
Iinuma
M
M
Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
Okawa
Y
Y
Tanaka
T
T
Ho
F C
FC
Kobayashi
Y
Y
Miyauchi
K I
KI
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D008826:Microbial Sensitivity Tests; D010944:Plants / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000890:Anti-Infective Agents; D005960:Glucosides; D007529:Isoflavones; C091400:ormosidin; C091401:dalbergion 4'-O-glucopyranoside