title: Stopping drinking and risk of oesophageal cancer.
abstract: OBJECTIVE
  To examine the effect of stopping drinking on the risk of oesophageal cancer.
  
  
  METHODS
  Hospital based case-control study.
  
  
  METHODS
  Surgical departments of four district general hospitals and general practices in Hong Kong.
  
  
  METHODS
  Cases were 400 consecutive admissions of patients with histologically confirmed diagnosis of oesophageal cancer during a 21 month period in 1989-90 (87% response rate). Controls were 1598 patients selected from the same surgical departments as the cases and from the general practices from which the cases were originally referred (95% response rate).
  
  
  METHODS
  Relative risk of developing oesophageal cancer after stopping drinking (adjusted for age, education, place of birth, smoking, and diet).
  
  
  RESULTS
  Current light drinking (< 200g ethanol/week) was not associated with significant increase in risk. Among former drinkers risk fell more quickly in moderate (200-599 g/week) than heavy (> or = 600 g/week) drinkers. Even among heavy drinkers, however, risk had dropped substantially after five to nine years of not drinking. The results suggest that the time taken for risk to return to that in subjects who never drink was 10-14 years for moderate drinkers and 15 years or more, if ever, for heavy drinkers.
  
  
  CONCLUSIONS
  Risk of oesophageal cancer decreases fairly rapidly with time after abstaining from drinking. This new finding could be used in health promotion to encourage behavioural changes, especially in heavy drinkers, who have a very high risk of developing oesophageal cancer. It also suggests that alcoholic beverages have a strong effect on the late stage of carcinogenesis.
authors.affiliation: Department of Public Health and Epidemiology, University of Birmingham, Edgbaston.
authors.forename: K K
authors.initials: KK
authors.lastname: Cheng
authors.forename: S W
authors.initials: SW
authors.lastname: Duffy
authors.forename: N E
authors.initials: NE
authors.lastname: Day
authors.forename: T H
authors.initials: TH
authors.lastname: Lam
authors.forename: S F
authors.initials: SF
authors.lastname: Chung
authors.forename: P
authors.initials: P
authors.lastname: Badrinath
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D004938:Esophageal Neoplasms / Q000209:etiology*; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013695:Temperance; D013997:Time Factors