title: [The effect of hemosorption on the level of endogenous intoxication and the immunity indices of patients with craniocerebral trauma].
abstract: Hemosorption as part of intensive therapy was made in 24 patients with severe and moderate craniocerebral injury. Due to the influence of toxic factors on the mechanisms responsible for the development of immune depression, the performance of the immune system could be normalized by disintoxication therapy as a tool of pathogenetic action on the main mechanisms of development of a pathological process. The investigations showed that the more effective the endogenous intoxication syndrome was levelled in craniocerebral injury, to the higher extent the major immunological parameters became normal in the shortest periods of time. Hemosorption substantially made the course of a traumatic disease milder by enhancing the efficiency of therapy for endotoxicosis. This effect mainly appeared as normalized metabolism and increased immune defense. Hemosorption improved the course of inflammatory complications, as evidenced by clinical features and laboratory findings. Hemosorption is effective prior to the occurrence of signs of clinical decompensation.
authors.forename: G I
authors.initials: GI
authors.lastname: Kovalev
authors.forename: A M
authors.initials: AM
authors.lastname: Tomnikov
authors.forename: G G
authors.initials: GG
authors.lastname: Muzlaev
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D001924:Brain Concussion / Q000150:complications / Q000276:immunology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006464:Hemoperfusion / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000209:etiology / Q000276:immunology / Q000628:therapy*
chemical_list: D000936:Antigen-Antibody Complex
vernacular_title: Vliianie gemosorbtsii na uroven' éndogennoĭ intoksikatsii i nekotorye pokazateli immuniteta u bol'nykh s cherepno-mozgovoĭ travmoĭ.