title: Effect of the lipopeptide antibiotic, iturin A, on morphology and membrane ultrastructure of yeast cells.
abstract: The effects of iturin A, at fungicidal concentrations, on yeast cells were studied by scanning electron microscopy and by transmission electron microscopy. A depression, observed in each iturin A-treated cell, was the consequence of the release of electrolytes and other cytoplasmic components. Iturin A passes through the cell wall and disrupts the plasma membrane with the formation of small vesicles and the aggregation of intramembranous particles. Moreover, iturin A passes through the plasma membrane and interacts with the nuclear membrane and probably with membranes of other cytoplasmic organelles.
authors.affiliation: Laboratoire de Biochimie Microbienne, Université Claude Bernard, Villeurbanne, France.
authors.forename: L
authors.initials: L
authors.lastname: Thimon
authors.forename: F
authors.initials: F
authors.lastname: Peypoux
authors.forename: J
authors.initials: J
authors.lastname: Wallach
authors.forename: G
authors.initials: G
authors.lastname: Michel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D005614:Freeze Fracturing; D008826:Microbial Sensitivity Tests; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D010455:Peptides; D010456:Peptides, Cyclic; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010455:Peptides; D010456:Peptides, Cyclic; C013579:iturin A