title: Effect of terdecamycin on experimentally induced swine dysentery in pigs.
abstract: The authors evaluated the effect of terdecamycin, a novel antibiotic, on experimentally induced Serpulina (S.) hyodysenteriae infection in pigs. In a prophylactic test, feed containing terdecamycin was fed to pigs for 7 days before inoculation and 21 days after inoculation. Dysenteric diarrhea, development of lesions in the large intestinal mucosa and colonization of S. hyodysenteriae in colonic mucosa were completely inhibited by treatment with 5 ppm or 10 ppm terdecamycin. In the therapeutic test, an unmedicated feed was fed to pigs inoculated with S. hyodysenteriae, until the typical mucohemorrhagic diarrhea appeared after inoculation, and was then changed to the medicated feed for 10 days. By treating with 20 ppm terdecamycin, the clinical signs in the pigs were improved and S. hyodysenteriae was completely eradicated.
authors.affiliation: Animal Health Research Laboratories, Takeda Chemical Industries, Ltd., Kyoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: N
authors.initials: N
authors.lastname: Narukawa
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017401:Brachyspira hyodysenteriae; D004403:Dysentery / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D018942:Macrolides; D013145:Spirochaetales Infections / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C091722:terdecamycin; C054134:sedecamycin