title: Molluscicidal saponins from a Zimbabwean strain of Phytolacca dodecandra.
abstract: Three new monodesmosidic saponins, all glycosides of 2 beta-hydroxyoleanolic acid, were isolated from an aqueous extract of a Zimbabwean strain of Phytolacca dodecandra. Their structures were, mainly by spectroscopic methods (LSIMS, 1H NMR, COSY, NOESY, TOCSY, J-resolved 1H NMR, 13C NMR, HETCOR), established as 3-O-[2',4'-di-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]2 beta-hydroxyoleanolic acid, 3-O-[O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-galactopyranosyl- (1-->3)]-beta-D-glucopyranosyl]2 beta-hydroxyoleanolic acid and 3-O-[3'-O-(beta-D-galactopyranosyl)-beta-D-glucopyranosyl]2 beta-hydroxyoleanolic acid. Two of the saponins were submitted to a preliminary screening for molluscicidal activity against the schistosomiasis transmitting snail Biomphalaria glabrata and showed, respectively, strong and weak activity. In addition, four saponins previously reported from other strains of Phytolacca dodecandra were identified.
authors.affiliation: Danish Bilharziasis Laboratory, Charlottenlund.
authors.forename: S T
authors.initials: ST
authors.lastname: Thiilborg
authors.forename: S B
authors.initials: SB
authors.lastname: Christensen
authors.forename: C
authors.initials: C
authors.lastname: Cornett
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
authors.forename: E
authors.initials: E
authors.lastname: Lemmich
mesh_terms: D000818:Animals; D001700:Biomphalaria; D002240:Carbohydrate Sequence; D002417:Cattle; D006460:Hemolysin Proteins / Q000302:isolation & purification; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D008975:Molluscacides / Q000302:isolation & purification*; D010944:Plants / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification*; D015030:Zimbabwe
chemical_list: D006460:Hemolysin Proteins; D008975:Molluscacides; D012503:Saponins