[The mitostatic activity of benzylpenicillin and aspisol in an experiment].
The changes occurring in the proliferation and differentiation of pluripotent hematopoietic stem cells under the action of different doses of benzylpenicillin and aspisole were investigated by using models of sublethally and lethally irradiated mice. The mitogenic and mitostatic dose-dependent effects of the drugs were revealed at the very early stages of immunogenesis and hemopoiesis. These effects show themselves in different ways (depending on the predominance of T- and B-lymphocytic conditions for T-B-cooperation and so on.
Red'kin
Iu V
IuV
Stepina
N I
NI
Lisnikova
V E
VE
D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D016026:Bone Marrow Transplantation / Q000276:immunology; D003114:Colony-Forming Units Assay; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects*; D010400:Penicillin G / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation
D008239:Lysine; D010400:Penicillin G; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Mitostaticheskaia aktivnost' benzilpenitsillina i aspizola v éksperimente.