[Alterations of oxygen free radicals in rabbit models and its relation to formation of pigment gallstones].
The experimental rabbits were divided into three groups. In the first group the common bile ducts were loosely ligated and contaminated by E. coli (BOI); in the second group the common bile ducts were only loosely ligated (BO); and the third group was the control group (Con). Alterations of oxygen free radicals were studied in all these models. The result showed that alterations of the partial hepatic oxygen free radicals (OFR), the hepatic prostaglandin E2 (PGE2) and the pigment gallstones were similar. There was a positive correlation among them (P < 0.05). In group BOI, these indexes were higher than in group BO. It is suggested that oxygen free radicals are possibly responsible for the formation of pigment gallstones through the pathway from oxygen free radicals to promote the production of prostaglandin E2, glycoprotein and pigment gallstones at last E. coli may aggravate the formation of pigment gallstones by increasing hepatic oxygen free radicals.
Liu
P
P
Center of Analysis and Test, Sichuan University.
Xiao
L
L
Chen
J
J
D000818:Animals; D001654:Bile Pigments / Q000378:metabolism; D001663:Bilirubin; D001651:Cholestasis, Extrahepatic / Q000150:complications / Q000382:microbiology; D003135:Common Bile Duct; D015232:Dinoprostone / Q000378:metabolism; D004927:Escherichia coli Infections / Q000150:complications; D005260:Female; D005609:Free Radicals; D042882:Gallstones / Q000209:etiology* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011817:Rabbits
D001654:Bile Pigments; D005609:Free Radicals; D015232:Dinoprostone; D001663:Bilirubin; D010100:Oxygen