[The effect of multiple administrations of beta-endorphin and an enkephalinase inhibitor into the rat caudate nucleus on the realization of an avoidance conditioned reflex].
Effects of daily within three weeks intrastriatal microinjections (5 mcg) of beta-endorphine and inhibitor of enkephalin-degrading enzymes N-carboxymethyl-Phe-Leu were studied in rats. Inhibition of avoidance conditioning in a shuttle-box was observed in both experimental groups. Influence of enkephalinase inhibitor was the most effective. No changes in motor activity were observed. The findings suggest an involvement of the endorphine neostriatal system in avoidance conditioning and complex behavioural acts.
Iakimovskiĭ
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D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D002421:Caudate Nucleus / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004151:Dipeptides / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008845:Microinjections / Q000379:methods; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D015260:Neprilysin / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D001615:beta-Endorphin / Q000008:administration & dosage*
D004151:Dipeptides; D001615:beta-Endorphin; C072596:N-carboxymethyl-phenylalanylleucine; D015260:Neprilysin
Vliianie mnogokratnykh vvedeniĭ beta-éndorfina i ingibitora énkefalinazy v khvostatoe iadro krys na realizatsiiu uslovnogo refleksa izbeganiia.