Cathestatins, new cysteine protease inhibitors produced by Penicillium citrinum.
New cysteine protease inhibitors, named cathestatin A and B, have been discovered as metabolites of Penicillium citrinum. Cathestatins were found to be decarbamidoyl analogs of estatins and showed a specific inhibition for cysteine proteases. Cathestatins suppressed parathyroid hormone (PTH)-stimulated 45Ca release in organ cultures of chick embryonic calvaria.
Woo
J T
JT
Sagami Chemical Research Center, Kanagawa, Japan.
Ono
H
H
Tsuji
T
T
D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy; D002118:Calcium / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002642:Chick Embryo; D015853:Cysteine Proteinase Inhibitors / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009924:Organ Culture Techniques; D010281:Parathyroid Hormone / Q000494:pharmacology; D010407:Penicillium / Q000378:metabolism*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D012886:Skull / Q000187:drug effects; D013329:Structure-Activity Relationship; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
D015853:Cysteine Proteinase Inhibitors; D004852:Epoxy Compounds; D010281:Parathyroid Hormone; C092939:cathestatin A; C092940:cathestatin B; D014443:Tyrosine; D010649:Phenylalanine; D002118:Calcium