Role of cellulose in wood dust-induced fibrosing alveo-bronchiolitis in rat.
Our experiments suggest that in the development of plant dust-induced fibrosing alveobronchiolitis--Scadding's fibrosing alveolitis--the cellulose content of plant dusts has a decisive aetiological role. Namely, the wood dust (pine) and the cellulose induced morphologically identical granulomatous inflammation and fibrosis, whereas the fibre-free extract of wood dust did not cause pathological changes in the lungs. The induction of H2O2 and superoxide anion production, shown in vitro in leucocytes, probably has an important role in the development of fibrosis.
Tátrai
E
E
National Institute of Occupational Health, Budapest, Hungary.
Adamis
Z
Z
Böhm
U
U
Merétey
K
K
Ungváry
G
G
D000818:Animals; D002482:Cellulose / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004391:Dust / Q000009:adverse effects*; D015726:Giant Cells / Q000166:cytology; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008297:Male; D016273:Occupational Exposure; D010100:Oxygen / Q000378:metabolism; D010316:Particle Size; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014132:Trachea / Q000187:drug effects / Q000378:metabolism; D014934:Wood
D004391:Dust; D002482:Cellulose; D006861:Hydrogen Peroxide; D010100:Oxygen