Human fetal somatic and visceral morphometrics.
Because of the increasing prenatal use of high-resolution ultrasonography to assess fetal growth and because growth aberration is one of the principal manifestations of abnormal intrauterine development, a more precise definition of normal growth is desirable. Our data set from autopsies of fetuses/neonates (50-4,000 g), collected with systematic attention to precision of measurement, is analyzed and presented. Previous computations of fetal growth curves appear to overstate the variation about the mean. Through the identification and exclusion of outliers and the use of appropriate curve fitting techniques, the problem of overestimation of variation about the mean has been largely eliminated. The new growth standards we present can be used to assess aberration from proportional growth and correlate it with gestational circumstances and particular morphological features of the fetus.
Barr
M
M
Department of Pediatrics, University of Michigan, Ann Arbor 48109.
Blackburn
W R
WR
Cooley
N R
NR
D000013:Congenital Abnormalities / Q000000981:diagnostic imaging*; D003625:Data Collection; D003627:Data Interpretation, Statistical; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D013048:Specimen Handling / Q000379:methods; D016216:Ultrasonography, Prenatal; D014781:Viscera / Q000196:embryology*