[Morphological and functional characteristics of myocardium in patients with cardiac insufficiency and its pharmacologic correction].
Contractile properties and micromorphology of the human myocardium were studied in bioptates of the right auricula at the heart failure and its pharmacological correction. It is shown that the chronoinotropic dependence of trabecular muscles of the human heart is a negative one. Vegetation of the connective tissue in the myocardium begins at the stage of development of its hypertrophy. Digoxin in combination with diuretics improves contractile properties and decreases expressiveness of dystrophic changes in myocardiocytes. Combination of the mentioned means with a blocker of the renin-angiotensin system, kapothenum in particular, not only improves the state of the contractile apparatus of the heart, but also causes a reverse development of the hyperplasive connective tissue.
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D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D002303:Cardiac Output, Low / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006332:Cardiomegaly / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D004077:Digoxin / Q000494:pharmacology / Q000627:therapeutic use*; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects*
D004232:Diuretics; D004077:Digoxin; D002216:Captopril
Morfofunktsionalńaia kharakteristika miokarda u liudeĭ pri serdechnoĭ nedostatochnosti i eë farmakologicheskaia korrektsiia.