Tumors in Rubinstein-Taybi syndrome.
The 14 tumors reported in Rubinstein-Taybi syndrome since 1989, when added to the 22 previously reported, are beginning to show a pattern of neural and developmental tumors, especially of the head, which is malformed in the syndrome. Among the neoplasms were 12 of the nervous system: 2 each of oligodendroglioma, medulloblastoma, neuroblastoma, and benign meningioma, a pheochromocytoma, and 3 other benign tumors; 2 of nasopharyngeal rhabdomyosarcoma; and 1 each of leiomyosarcoma, seminoma, and embryonal carcinoma. Among the other benign tumors were an odontoma, a choristoma, a dermoid cyst, and 2 pilomatrixomas.
Miller
R W
RW
Clinical Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892-7360, USA.
Rubinstein
J H
JH
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications; D009380:Neoplasms, Nerve Tissue / Q000150:complications; D009423:Nervous System Neoplasms / Q000150:complications; D012415:Rubinstein-Taybi Syndrome / Q000150:complications*