Heterocyclic betaines. XXII. Azinium(azolium) 4-nitrobenzimidazolate inner salts and their derivatives with several interannular spacers. Synthesis, characterization and antitrichomonal activity.
The synthesis of an ensemble of pyridinium(imidazolium) 4-nitrobenzimidazolate betaines and their derivatives with several interannular linkages has been explored. Their antiprotozoal activity has also been examined.
Alcalde
E
E
Laboratorio de Química Orgánica, Facultad de Farmacia, Universidad de Barcelona, Spain.
Pérez-García
L
L
Dinarés
I
I
Frigola
J
J
D000818:Animals; D000994:Antitrichomonal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects
D000994:Antitrichomonal Agents; D001562:Benzimidazoles; D001622:Betaine