Relationship of histology, DNA-values and proliferative activity in unselected breast cancer patients (a preliminary study).
Based upon a group of 108 consecutive mammary carcinomas a comparative analysis of morphological parameters, DNA-ploidy and indicators of proliferation activity was made. A correlation between Bloom-Richardson scale, mitotic index, PCNA-labeling index and DNA-index was shown. The ploidy of mammary carcinomas was significantly related to the values of proliferative fraction, as well as to PCNA-labeling index. Among patients with axillary metastases the tumor size and the value of PCNA-labeling index were significantly higher than those in patients with negative lymph nodes.
Niezabitowski
A
A
Department of Tumor Pathology, Epidemiology and Surgery, Center of Oncology, Kraków.
Ryś
J
J
Lackowska
B
B
Dyba
T
T
Stelmach
A
A
Gruchała
A
A
Wasilewska
A
A
Szklarski
W
W
Kruczak
A
A
Swiatkiewicz
I
I
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D002277:Carcinoma / Q000235:genetics / Q000473:pathology* / Q000556:secondary; D002455:Cell Division; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis
D004273:DNA, Neoplasm