Role of dopaminoreactive systems of the cortex and the neostriatum in the organization of situational conditioned reflexes.
The results of experiments on dogs with dysfunction of the dopaminoreactive system of the brain suggest the nonidenticality of its different divisions (cortical, striatal, mesencephalic) in the organization of situational conditioned reflexes. It was demonstrated that the nigrostriatal system is involved to a greater degree in the spatial analysis of signals, while the mesocortical system is more involved in the analysis of their biological significance. The dopaminoreactive system of the caudate nucleus is associated to a greater degree with the realization of cognitive, while that of the putamen is associated with the realization of motor programs of situational conditioned reflexes. The thesis of the necessity of the coordinated functioning of the DA-reactive systems for the organization of goal-directed behavior is substantiated.
Voilokova
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Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg.
D000161:Acoustic Stimulation; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D017072:Neostriatum / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine; D017397:Prefrontal Cortex / Q000502:physiology; D011699:Putamen / Q000502:physiology; D013681:Tegmentum Mesencephali / Q000502:physiology
D016627:Oxidopamine; D006220:Haloperidol; D004298:Dopamine