title: Fatty acids and adipose cell differentiation.
abstract: Fatty acids are important metabolic substrates for adipose tissue. In preadipose cells, fatty acids are also potent inducers of various genes encoding proteins directly involved in fatty acid metabolism. On a longer-term basis, fatty acids induce the terminal differentiation of preadipose to adipose cells. Fatty acids act primarily at a transcriptional level. A member of the steroid/thyroid hormone receptor superfamily has been identified by cDNA cloning from a mouse Ob1771 preadipose cell library. This receptor is likely the fatty acid-activated receptor implicated in the transcriptional effects of fatty acids in adipose cells. Thus fatty acids appear to play a new role as signal transducing molecules which are involved in adipose cell differentiation.
authors.affiliation: Centre de Biochimie (UMR 134 CNRS), Université de Nice-Sophia Antipolis, Faculté des Sciences, France.
authors.forename: G
authors.initials: G
authors.lastname: Ailhaud
authors.forename: E Z
authors.initials: EZ
authors.lastname: Amri
authors.forename: P A
authors.initials: PA
authors.lastname: Grimaldi
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D005227:Fatty Acids / Q000494:pharmacology*; D005786:Gene Expression Regulation; D015723:Gene Library; D051379:Mice; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology
chemical_list: D005227:Fatty Acids; C091778:Ppard protein, mouse; D018160:Receptors, Cytoplasmic and Nuclear