title: The pathogenesis of hypertrophic/keloid scarring.
abstract: The formation of hypertrophic and keloid scars after cutaneous wounding is of particular relevance to the practice of maxillofacial surgery. This paper reviews current knowledge of the local and systemic factors underlying the formation of these scars and outlines the current and potential treatment modalities for these lesions.
authors.affiliation: Department of Oral Surgery, Medicine and Pathology, Cardiff Dental School, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Thomas
authors.forename: I
authors.initials: I
authors.lastname: Hopkinson
authors.forename: K G
authors.initials: KG
authors.lastname: Harding
authors.forename: J P
authors.initials: JP
authors.lastname: Shepherd
mesh_terms: D017439:Cicatrix, Hypertrophic / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D003094:Collagen / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005151:Facial Injuries / Q000150:complications; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D007627:Keloid / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014945:Wound Healing / Q000276:immunology / Q000502:physiology
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D016212:Transforming Growth Factor beta; D003094:Collagen