title: Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors.
abstract: The role of the epidermal growth factor (EGF) receptor in cell invasion by Salmonella typhimurium was examined in vitro and in vivo by using waved-2 mice which express an EGF receptor with reduced kinase activity. S. typhimurium invaded fibroblasts from waved-2 mice as efficiently as fibroblasts from wild-type control animals. In vivo, S. typhimurium both invaded the gastrointestinal tract and penetrated through to the spleen of waved-2 mice. Our studies suggest that the EGF receptor has only a limited role, if any, in cell invasion by S. typhimurium.
authors.affiliation: Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: A
authors.initials: A
authors.lastname: McNeil
authors.forename: S J
authors.initials: SJ
authors.lastname: Dunstan
authors.forename: S
authors.initials: S
authors.lastname: Clark
authors.forename: R A
authors.initials: RA
authors.lastname: Strugnell
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D066246:ErbB Receptors / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D010581:Peyer's Patches / Q000382:microbiology; D010766:Phosphorylation; D012481:Salmonella Infections, Animal / Q000382:microbiology; D012486:Salmonella typhimurium / Q000472:pathogenicity*; D013154:Spleen / Q000382:microbiology
chemical_list: D066246:ErbB Receptors