title: Oxygen transport and hemodynamics during retrograde whole-body perfusion.
abstract: The changes in oxygen transport and hemodynamics during retrograde whole-body extracorporeal perfusion (retro-ECC) were studied in six mongrel dogs. Oxygen consumption during retro-ECC, in which the blood flow rate was set at 25% and 50% of the flow during antegrade extracorporeal perfusion (ante-ECC), respectively, was relatively high compared with that during ante-ECC. These changes were caused by an increase in the oxygen extraction ratio to 71.5% +/- 8.2% and 51.2% +/- 12.4% during retro-ECC/25% and retro-ECC/50%, respectively. Thus, tissue perfusion was apparently well maintained by retrograde perfusion on the basis of the oxygen transport data. However, central venous pressure increased markedly to 29.5 +/- 11.6 mmHg and 56.2 +/- 24.5 mmHg during retro-ECC/25% and retro-ECC/50%, respectively, because of massive venous congestion caused by insufficient arterial return of perfused blood. The great venous compliance and increased systemic vascular resistance were the main causes of circulatory failure during retro-ECC. The risk of serious complications owing to the venous congestion must be considered during retrograde perfusion, especially during the clinical application of retrograde cerebral perfusion.
authors.affiliation: Department of Anesthesiology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shime
authors.forename: T
authors.initials: T
authors.lastname: Hatanaka
authors.forename: M
authors.initials: M
authors.lastname: Fukui
authors.forename: H
authors.initials: H
authors.lastname: Tojo
authors.forename: M
authors.initials: M
authors.lastname: Yoshioka
authors.forename: M
authors.initials: M
authors.lastname: Yang
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D002496:Central Venous Pressure / Q000502:physiology; D004285:Dogs; D004487:Edema / Q000150:complications / Q000503:physiopathology; D005112:Extracorporeal Circulation / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology*; D010477:Perfusion; D012769:Shock / Q000209:etiology / Q000503:physiopathology; D014018:Tissue Distribution; D014655:Vascular Resistance / Q000502:physiology; D014680:Veins; D014689:Venous Insufficiency / Q000150:complications / Q000503:physiopathology
chemical_list: D010100:Oxygen