Malignant germ cell tumors of the ovary: Hacettepe hospital experience.
BACKGROUND
To determine the most important prognostic factors in patients with malignant germ cell tumors of the ovary.


METHODS
Age, histologic type, tumor size, stage, treatment mode, type of surgery of 67 patients with malignant germ cell tumors managed consecutively were evaluated retrospectively using multivariate analysis.


RESULTS
The overall survival rate was 60.6%. This figure was 78.5% for dysgerminoma, 53.3% for immature teratoma, 12.0% for endodermal sinus tumor, 33.3% for mixed germ cell tumor and 100.0% for others. The patients with endodermal sinus tumor had significantly poorer survival than other groups. Among the factors analyzed for survival histologic type was found to be the most significant predictor for survival.


CONCLUSIONS
Finding of histologic type as the strongest independent risk factor may be evaluated in correlation with the literature that these tumors have historically been investigated as dysgerminomatous and nondysgerminomatous tumors. Furthermore, endodermal sinus tumors had long been known for poor survival. Based on this data, despite advent of staging and effective chemotherapy, prognosis still is basically related to histologic type and histology of tumor should be taken into account while comparing results.
Ayhan
A
A
Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
Tuncer
Z S
ZS
Yanik
F
F
Bükülmez
O
O
Yanik
A
A
Küçükali
T
T
D000328:Adult; D004407:Dysgerminoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018240:Endodermal Sinus Tumor / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D018237:Germinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009775:Obstetrics and Gynecology Department, Hospital; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013724:Teratoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014421:Turkey