title: Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.
abstract: Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.
authors.affiliation: Selectide Corporation, Tucson, AZ 85737, USA.
authors.forename: N F
authors.initials: NF
authors.lastname: Sepetov
authors.forename: V
authors.initials: V
authors.lastname: Krchnák
authors.forename: M
authors.initials: M
authors.lastname: Stanková
authors.forename: S
authors.initials: S
authors.lastname: Wade
authors.forename: K S
authors.initials: KS
authors.lastname: Lam
authors.forename: M
authors.initials: M
authors.lastname: Lebl
mesh_terms: D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal; D001426:Bacterial Proteins / Q000276:immunology; D015195:Drug Design; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D019809:Streptavidin; D001615:beta-Endorphin / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D001426:Bacterial Proteins; D010455:Peptides; D001615:beta-Endorphin; D019809:Streptavidin