Tonic pupil and orbital glial-neural hamartoma in infancy.
OBJECTIVE
Tonic pupils in early childhood are rare. We studied an otherwise healthy 31/2-month-old girl who had a right pupil that was poorly reactive to light, without other signs of oculomotor nerve palsy.


CONCLUSIONS
Constriction of the right pupil after instillation of 0.125% pilocarpine eyedrops confirmed denervation hypersensitivity, consistent with a tonic pupil. There was no strabismus or proptosis. A magnetic resonance imaging scan demonstrated a right orbital mass, interposed between the lateral and inferior recti muscles. Biopsy was consistent with a benign, glial-neural hamartoma. Thus, in this young patient, a tonic pupil was associated with a benign orbital mass.
Brooks-Kayal
A R
AR
Neurology Service, University of Pennsylvania School of Medicine, USA.
Liu
G T
GT
Menacker
S J
SJ
Heher
K L
KL
Katowitz
J A
JA
Bilaniuk
L T
LT
D002675:Child, Preschool; D005260:Female; D006222:Hamartoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009457:Neuroglia / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D009915:Orbit / Q000473:pathology; D009916:Orbital Diseases / Q000150:complications / Q000175:diagnosis*; D015845:Tonic Pupil / Q000175:diagnosis* / Q000209:etiology