title: Isolation, characterization and structure of a new allenic polyine antibiotic produced by fungus LL-07F275.
abstract: Antibiotic 07F275 (1), produced by submerged fermentations of fungal culture LL-07F275, was isolated and characterized despite its inherent instability. Its UV spectrum was identical with that of nemotin, a member of the allenic polyacetylene family, but a molecular weight of 218 daltons indicated a new compound. Structure 1 was determined on the basis of spectroscopic evidence, particularly NMR. Since 1 is a thirteen carbon-containing allenic diyne, it is closely related to mycomycin.
authors.affiliation: American Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, N.Y. USA 10965, USA.
authors.forename: G
authors.initials: G
authors.lastname: Schlingmann
authors.forename: L
authors.initials: L
authors.lastname: Milne
authors.forename: C J
authors.initials: CJ
authors.lastname: Pearce
authors.forename: D B
authors.initials: DB
authors.lastname: Borders
authors.forename: M
authors.initials: M
authors.lastname: Greenstein
authors.forename: W M
authors.initials: WM
authors.lastname: Maiese
authors.forename: G T
authors.initials: GT
authors.lastname: Carter
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000378:metabolism; D008826:Microbial Sensitivity Tests
chemical_list: D000480:Alkynes; D000900:Anti-Bacterial Agents; C094348:antibiotic 07F275