[Antioxidant effect of a Ural licorice product in acute impairment of pulmonary surfactant by total gamma irradiation].
Total single irradiation of rats at a dose of 2 Gy caused activation of lipid peroxidation in lung surfactant and blood serum within 7 days. Most pronounced alterations occurred in content of 2-thiobarbituric acid-positive substances and in activity of the antioxidant system enzymes. Administration of the preparation isolated from Liquorice uraliensis within 2 weeks before the irradiation and within 7 days after the treatment contributed to inhibition of the radiation-induced lipid peroxidation.
Palagina
M V
MV
Khasina
M A
MA
Gel'tser
B I
BI
Deviatov
A L
AL
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005720:Gamma Rays; D006035:Glycyrrhiza / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000528:radiation effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011663:Pulmonary Surfactants / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats
D000975:Antioxidants; D010936:Plant Extracts; D011663:Pulmonary Surfactants
Antiokislitel'noe deĭstvie preparata solodki ural'skoĭ pri ostrom porazhenii surfaktanta legkikh total'nym gamma-oblucheniem.