title: Acute interstitial nephritis associated with ticlopidine.
abstract: Ticlopidine, a platelet aggregation inhibitor, has been approved to decrease the risk of thrombotic stroke. We describe a 75-year-old white woman who developed acute renal failure 10 days after initiating ticlopidine therapy. A renal biopsy revealed interstitial infiltrates containing lymphocytes and eosinophils. To our knowledge this is the first report of ticlopidine-induced acute interstitial nephritis.
authors.affiliation: Department of Medicine, Coney Island Hospital, Brooklyn, NY 11235, USA.
authors.forename: H
authors.initials: H
authors.lastname: Rosen
authors.forename: A S
authors.initials: AS
authors.lastname: el-Hennawy
authors.forename: S
authors.initials: S
authors.lastname: Greenberg
authors.forename: C K
authors.initials: CK
authors.lastname: Chen
authors.forename: A D
authors.initials: AD
authors.lastname: Nicastri
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000368:Aged; D001706:Biopsy; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D013988:Ticlopidine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013988:Ticlopidine