Role of infection in the genesis of acute renal failure.
While most experimental models of acute renal failure (ARF) involve ischaemic or toxic damage to the kidney in non-infected animals, a surprisingly large proportion of patients with ARF exhibit signs of septicaemia or systemic reaction to local infections. This clinical observation suggests an important role of infection-related mediator mechanisms in the genesis of ARF. Another important aspect is the occurrence of ARF in the context of infections with nephrotropic viruses (e.g. hantavirus accounting for approximately 5% of non-surgical ARF in Germany) and nephrotropic bacteria (e.g. leptospirosis).
Wiecek
A
A
Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany.
Zeier
M
M
Ritz
E
E
D058186:Acute Kidney Injury / Q000453:epidemiology / Q000209:etiology* / Q000266:history; D000818:Animals; D001424:Bacterial Infections / Q000150:complications; D016207:Cytokines / Q000502:physiology; D004731:Endotoxins / Q000633:toxicity; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007239:Infections / Q000150:complications*
D016207:Cytokines; D004731:Endotoxins