title: Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.
abstract: Cytokines of the TGF beta superfamily regulate many aspects of cellular function by activating receptor complexes consisting of two distantly related serine/threonine kinases. Previous studies have indicated that Drosophila dpp uses similar signaling complexes and strictly requires the punt and thick veins receptors to transduce the signal across the membrane. Here, we show that the schnurri (shn) gene is required for many aspects of dpp signaling. Genetic epistasis experiments indicate that shn functions downstream of the dpp signal and its receptors. The shn gene encodes a large protein similar to a family of mammalian zinc finger transcription factors. The shn protein might therefore act as a nuclear target in the dpp signaling pathway directly regulating the expression of dpp-responsive genes.
authors.affiliation: Biozentrum, Universität Basel, Switzerland.
authors.forename: N C
authors.initials: NC
authors.lastname: Grieder
authors.forename: D
authors.initials: D
authors.lastname: Nellen
authors.forename: R
authors.initials: R
authors.lastname: Burke
authors.forename: K
authors.initials: K
authors.lastname: Basler
authors.forename: M
authors.initials: M
authors.lastname: Affolter
mesh_terms: D029404:Activin Receptors; D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004064:Digestive System / Q000196:embryology; D004330:Drosophila / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins; D004707:Endoderm / Q000502:physiology; D005260:Female; D017344:Genes, Insect / Q000235:genetics*; D017403:In Situ Hybridization; D007301:Insect Hormones / Q000378:metabolism; D008648:Mesoderm / Q000502:physiology; D008969:Molecular Sequence Data; D009154:Mutation; D010641:Phenotype; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000235:genetics*; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D016335:Zinc Fingers
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C063232:HIVEP1 protein, human; D007301:Insect Hormones; D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor; D014157:Transcription Factors; C064196:dpp protein, Drosophila; C094066:shn protein, Drosophila; C090169:tkv protein, Drosophila; D017346:Protein Serine-Threonine Kinases; D029404:Activin Receptors