title: Potential radioprotective agents--IV. Schiff bases.
abstract: Twelve Schiff bases were prepared using salicylaldehyde, one with 5-chlorosalicylaldehyde, one with benzaldehyde, and a series of anilines substituted in the m- or p-positions. They were assayed for radioprotective activity in male, Swiss mice irradiated with a nearly lethal dose (950 cGy) of 6 mV photons produced by a linear accelerator, and were compared with the parent amines. Schiff base formation reduced toxicity of the parent amines; its effect on radioprotective activity was erratic, increasing activity in some cases, decreasing activity in others, and having no effect in still others. Radioprotective activity appears to be unrelated to a number of molecular descriptors. The highest radioprotection (100%) was observed for mixtures of p-aminopropiophenone with its Schiff base, or with the Schiff base of 1-(p-aminophenyl)-1-propanol (95%).
authors.affiliation: Richard L. Roudebush VA Medical Center, Department of Biochemistry & Molecular Biology, Indianapolis, IN, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Blickenstaff
authors.forename: S
authors.initials: S
authors.lastname: Reddy
authors.forename: R
authors.initials: R
authors.lastname: Witt
authors.forename: K B
authors.initials: KB
authors.lastname: Lipkowitz
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D006860:Hydrogen Bonding; D008297:Male; D051379:Mice; D011427:Propiophenones / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D014916:Whole-Body Irradiation
chemical_list: D000588:Amines; D011427:Propiophenones; D011837:Radiation-Protective Agents; D012545:Schiff Bases; C029564:4-aminopropiophenone