title: The effects of inhalational anesthetics on ischemic injury of rat kidney with renovascular occlusion.
abstract: The effects of halogenated inhalational anesthetics, viz. halothane, enflurane, isoflurane and sevoflurane, on ischemic rat kidneys were studied through the response of renal gamma-glutamyl transpeptidase in the brush border of proximal tubules to monoclonal antibodies. Brush border staining characteristics were evaluated as follows: a) continuous (normal), b) discontinuous (damaged) and c) indistinct (necrotic). The isoflurane group had significantly fewer damaged and/or necrotic proximal tubules compared to the other groups. These results suggest that isoflurane is the most appropriate inhalational anesthetic when renal circulation is impaired.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Minoda
authors.forename: T
authors.initials: T
authors.lastname: Sameshima
authors.forename: J
authors.initials: J
authors.lastname: Miyao
authors.forename: N
authors.initials: N
authors.lastname: Yoshimura
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D003250:Constriction; D004737:Enflurane / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D007511:Ischemia; D007530:Isoflurane / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008738:Methyl Ethers; D008871:Microvilli / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D000077149:Sevoflurane; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D004737:Enflurane; D007530:Isoflurane; D005723:gamma-Glutamyltransferase; D006221:Halothane