Antiplatelet aggregation principles of Dendrobium loddigesii.
The MeOH extract of the stem of Dendrobium loddigesii was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid and collagen. Two active compounds, moscatilin [1] and moscatin [2], were isolated. Moscatilin diacetate [3] also exhibited antiplatelet aggregation activity.
Chen
C C
CC
National Research Institute of Chinese Medicine, Taipei Hsien, Taiwan.
Wu
L G
LG
Ko
F N
FN
Teng
C M
CM
D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001593:Benzyl Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D003094:Collagen / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D066298:In Vitro Techniques; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits
D001593:Benzyl Compounds; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; D010975:Platelet Aggregation Inhibitors; C091085:moscatin; C071845:dendrophenol; D016718:Arachidonic Acid; D003094:Collagen