title: Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome.
abstract: The justification for disordered chronobiology for fibromyalgia and chronic fatigue syndrome (CFS) is based on the following evidence: The studies on disordered sleep physiology and the symptoms of fibromyalgia and CFS; the experimental studies that draw a link between interleukin-1 (IL-1), immune-neuroendocrine-thermal systems and the sleep-wake cycle; studies and preliminary data of the inter-relationships of sleep-wakefulness, IL-1, and aspects of peripheral immune and neuroendocrine functions in healthy men and in women during differing phases of the menstrual cycle; and the observations of alterations in the immune-neuroendocrine functions of patients with fibromyalgia and CFS (Moldofsky, 1993b, d). Time series analyses of measures of the circadian pattern of the sleep-wake behavioural system, immune, neuroendocrine and temperature functions in patients with fibromyalgia and CFS should determine whether alterations of aspects of the neuro-immune-endocrine systems that accompany disordered sleep physiology result in nonrestorative sleep, pain, fatigue, cognitive and mood symptoms in patients with fibromyalgia and CFS.
authors.affiliation: Centre for Sleep and Chronobiology, Toronto Hospital, Western Division, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Moldofsky
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation; D002940:Circadian Rhythm / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D004569:Electroencephalography; D015673:Fatigue Syndrome, Chronic / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005356:Fibromyalgia / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007239:Infections / Q000150:complications / Q000276:immunology; D007375:Interleukin-1 / Q000502:physiology*; D008297:Male; D008959:Models, Neurological; D015213:Neuroimmunomodulation; D009479:Neuropeptides / Q000502:physiology; D009490:Neurosecretory Systems / Q000503:physiopathology*; D051381:Rats; D012894:Sleep Stages / Q000502:physiology; D012893:Sleep Wake Disorders / Q000150:complications* / Q000276:immunology
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D009479:Neuropeptides