Effects of cocaine on P3B in cocaine abusers.
Little is known about the effects of cocaine on cognitive tasks. Event-related potentials (ERP) were recorded in 7 cocaine abusers during the performance of the auditory oddball task before and after the intravenous injections of saline and cocaine (60-80 mg). The P3B and slow wave components of the ERP were significantly larger 60-210 min after the cocaine than after the placebo injection. The results suggest that cocaine abusers have difficulty in maintaining optimal stimulus processing during extended testing. Cocaine blocks this decrement in stimulus processing.
Herning
R I
RI
Molecular Neuropsychiatry Section, National Institutes of Health, National Institute on Drug Abuse, Baltimore, Md 21224.
Glover
B J
BJ
Guo
X
X
D000328:Adult; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001288:Attention / Q000187:drug effects* / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D003042:Cocaine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D015819:Substance Abuse, Intravenous / Q000503:physiopathology / Q000534:rehabilitation; D019966:Substance-Related Disorders / Q000503:physiopathology* / Q000534:rehabilitation
D003042:Cocaine