Acute myeloblastic leukemia associated with an intermediate state between the healthy carrier state and adult T-cell leukemia.
This report describes an intermediate state between the human T-cell lymphotropic virus type I (HTLV-I) healthy carrier and adult T-cell Leukemia (ATL) who developed acute myeloblastic leukemia (AML, FAB subtype M2). The polyclonal integration of HTLV-I proviral DNA was demonstrated in the peripheral blood lymphoid cells, whereas AML cells had no HTLV-I proviral DNA. The patient achieved remission after combination chemotherapy but cells with lobulated nuclei persist at a low level and the polyclonal integration of HTLV-I proviral DNA is still demonstrated. We suggest that the patients with the integration of HTLV-I proviral DNA might develop secondary neoplasms more frequently than healthy carriers and this case stresses the need to exercise caution with these patients. The relationship between HTLV-I and AML is briefly discussed.
Kawachi
Y
Y
Department of Internal Medicine, Takamatsu Red Cross Hospital, Kagawa, Japan.
Watanabe
A
A
Sakamoto
Y
Y
Abe
T
T
Uchida
T
T
Sacho
M
M
Mori
M
M
Setsu
K
K
D000328:Adult; D002353:Carrier State / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification; D004198:Disease Susceptibility; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000821:virology; D008297:Male; D009378:Neoplasms, Multiple Primary; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000821:virology; D011533:Proviruses / Q000302:isolation & purification
D004279:DNA, Viral