[A comprehensive clinico-neurophysiological study of the efficacy of the pharmaceutical preparation glycine in acute ischemic stroke].
In intensive care unit 226 patients underwent step-by-step clinical and neurophysiological investigation of glycin chemotherapy efficiency in the acute period of ischaemic stroke. Investigation included double-blind placebo controlled method, monitoring (by means of EEG, toposelective mapping of EEG, SSEP, transcutaneous cortical electric stimulation, ENMG) of changes of brain functional state after the first drug dose and course of treatment, analysis of dose-dependent action of the drug, posticchemic follow-up. It was found out, that usage of the drug glycin (daily dose 1-2 grams) in the combined intensive treatment of stroke provided for significant acceleration of regress of disorders of consciousness and other general and focal signs (in comparison with severity-matched control group), and more complete and stable restoration of function to the end of acute period of the disease.
Skvortsova
V I
VI
Gusev
E I
EI
Komissarova
I A
IA
Kovalenko
A V
AV
Bolotov
D A
DA
Fidler
S M
SM
Fedorov
V N
VN
D000208:Acute Disease; D000368:Aged; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005998:Glycine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods / Q000706:statistics & numerical data; D009460:Neurologic Examination / Q000706:statistics & numerical data; D013997:Time Factors
D005998:Glycine
Kompleksnoe kliniko-neĭrofiziologicheskoe izuchenie éffektivnosti farmatsevticheskogo preparata glitsina v ostrom periode ishemicheskogo insul'ta.