Modulatory influence of the oral contraceptive pill, Ovral, on 3-methylcholanthrene-induced carcinogenesis in the uterus of mouse.
The present study examines the modulatory influence of the combined oral contraceptive pill, Ovral (0.05 mg ethynylestradiol plus 0.25 mg levonorgestrel per pill) on methylcholanthrene (MCA)-induced carcinogenesis in the uterus of Swiss albino mouse. Placement of cotton thread impregnated with beeswax containing approximately 600 micrograms of MCA, yielded endometrial squamous cell carcinomas in 53.33% animals in 90 days. Concomitant treatments with doses D1 (1/200th of a pill) and D2 (1/200th of a pill) of Ovral yielded endometrial squamous cell carcinomas in 6.23 and 0% of animals in 90 days (p < 0.05; p < 0.005) respectively. Ovral did not seem to increase the incidence of uterine hyperplasia.
Chhabra
S K
SK
Cancer Biology Laboratory, Jawaharlal Nehru University, New Delhi, India.
Kaur
S
S
Rao
A R
AR
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D008748:Methylcholanthrene; D051379:Mice; D009644:Norgestrel / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000139:chemically induced*
D003278:Contraceptives, Oral, Hormonal; D009644:Norgestrel; D004997:Ethinyl Estradiol; D008748:Methylcholanthrene; D019304:Ethinyl Estradiol-Norgestrel Combination