The influence of patch tests with clobetasol propionate on adjacent patch test reactions.
Contact allergy to corticosteroids now seems frequent among patients being patch tested. As corticosteroids are intrinsically anti-inflammatory, we investigated whether patch tests with a potent corticosteroid might suppress simultaneous adjacent patch test reactions to another allergen. Nickel-sensitive subjects were patch tested with an aqueous dilution series of nickel in duplicate, adjacent to patch tests with clobetasol propionate 1% in ethanol and with ethanol, respectively. Statistical evaluation of the results obtained in 2 different centers, using their own patch test techniques, did not reveal any suppression of the positive nickel patch test reactions.
Bruze
M
M
Department of Occupational Dermatology, General Hospital, Malmö, Sweden.
Isaksson
M
M
Dooms-Goossens
A
A
D002990:Clobetasol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000503:physiopathology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D009532:Nickel / Q000009:adverse effects*; D010328:Patch Tests / Q000009:adverse effects / Q000379:methods*; D012867:Skin / Q000187:drug effects
D000431:Ethanol; C029938:nickel sulfate; D009532:Nickel; D002990:Clobetasol