title: Correlation between gold-induced enterocolitis and the presence of the HLA-DRB1*0404 allele.
abstract: OBJECTIVE
  In recent years we have treated 4 rheumatoid arthritis (RA) patients who developed gold-induced enterocolitis, a well-recognized, although rare, complication of chrysotherapy. The aim of the present study was to seek any genetic predisposition for this complication.
  
  
  METHODS
  HLA DNA typing was done on fresh white blood cells from the 4 patients.
  
  
  RESULTS
  Three of the 4 patients (75%) exhibited the DRB1*0404 allele, whereas the prevalence of this allele among the Ashkenazi Jewish population of RA patients without colitis was 9.2% and 10.2% in 2 different studies.
  
  
  CONCLUSIONS
  The results indicate that the DRB1*0404 may be associated with risk for the development of gold-induced enterocolitis in this population and suggest that HLA DNA typing should be considered in Jews who may be undergoing chrysotherapy.
authors.affiliation: Kaplan Hospital, Rehovot, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Evron
authors.forename: C
authors.initials: C
authors.lastname: Brautbar
authors.forename: S
authors.initials: S
authors.lastname: Becker
authors.forename: G
authors.initials: G
authors.lastname: Fenakel
authors.forename: Y
authors.initials: Y
authors.lastname: Abend
authors.forename: Z
authors.initials: Z
authors.lastname: Sthoeger
authors.forename: P
authors.initials: P
authors.lastname: Cohen
authors.forename: D
authors.initials: D
authors.lastname: Geltner
mesh_terms: D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000453:epidemiology; D015984:Causality; D004247:DNA / Q000032:analysis / Q000235:genetics; D004760:Enterocolitis / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D006046:Gold / Q000009:adverse effects* / Q000627:therapeutic use; D006684:HLA-DR Antigens / Q000235:genetics* / Q000378:metabolism; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007585:Jews / Q000706:statistics & numerical data; D008875:Middle Aged; D044465:White People / Q000235:genetics
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D006046:Gold; D004247:DNA