Alpha-subunit of beta-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis.
One of the major allergenic proteins in the soybean 7S-globulin fraction, which was recognized by sera of about 25% soybean-sensitive patients with atopic dermatitis, was identified as alpha-subunit of beta-conglycinin. The IgE antibodies recognizing the alpha-subunit did not show a cross-reactivity against both alpha'- and beta-subunits known to be highly homologous to alpha-subunit, and also against other allergenic components identified in soybeans [Ogawa et al., J. Nutr. Sci. Vitaminol., 35, 555-565 (1993)]. The IgE-binding site(s) was estimated to be located on the peptide 232-283 of alpha-subunit.
Ogawa
T
T
Department of Nutrition, School of Medicine, University of Tokushima, Japan.
Bando
N
N
Tsuji
H
H
Nishikawa
K
K
Kitamura
K
K
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D052179:Antigens, Plant; D002648:Child; D002675:Child, Preschool; D002918:Chymotrypsin / Q000737:chemistry / Q000378:metabolism; D003488:Cyanogen Bromide / Q000737:chemistry / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000150:complications / Q000276:immunology*; D005916:Globulins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D007223:Infant; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism; D010940:Plant Proteins / Q000276:immunology; D055314:Seed Storage Proteins; D030262:Soybean Proteins; D013025:Glycine max / Q000276:immunology*
D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D052179:Antigens, Plant; D005916:Globulins; D010446:Peptide Fragments; D010940:Plant Proteins; D055314:Seed Storage Proteins; D030262:Soybean Proteins; C013894:beta-conglycinin protein, Glycine max; D007073:Immunoglobulin E; D002918:Chymotrypsin; D003488:Cyanogen Bromide