Multiple paraneoplastic syndromes in a patient with antibodies to neuronal nucleoproteins (anti-Hu).
We report the clinical and autopsy studies of a patient with an unusual combination of multiple paraneoplastic neurological syndromes in association with antibodies to a 35-40 kDa neuronal nucleo-protein (anti-Hu). Neurological disease preceded the detection of a small cell carcinoma of the lung. The patient had combined sensory and motor neuronopathy or neuropathy, cerebellar degeneration, brain-stem and limbic encephalitis, and clinical evidence of the Lambert-Eaton myasthenic syndrome and gastrointestinal pseudo-obstruction of paraneoplastic origin.
Heidenreich
F
F
Neurologische Klinik, Medizinische Hochschule Hannover, Germany.
Schober
R
R
Brinck
U
U
Hartung
H P
HP
D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western; D018288:Carcinoma, Small Cell; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009474:Neurons / Q000737:chemistry / Q000276:immunology*; D009698:Nucleoproteins / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies; D009419:Nerve Tissue Proteins; D009698:Nucleoproteins