Effect of huoxuequyu recipe on erythrocyte membrane Ca(2+)-ATPase activity in pregnant rats with asymmetrical intrauterine growth retardation induced by passive smoking.
The effect of Huoxuequyu recipe on erythrocyte membrane Ca(2+)-ATPase activity in pregnant rats with passive smoking induced asymmetrical intrauterine growth retardation (IUGR) was observed. The rats were divided into three groups: control group, model group and treated group. The fetal mean birth weight and erythrocyte membrane Ca(2+)-ATPase activity were found to be decreased in the model group as compared with the control and treated groups. There was a significant difference between the model group and the control group (P < 0.01), while no significant difference existed between the treated group and the control group (P > 0.05). Furthermore, the findings indicated that the erythrocyte membrane Ca(2+)-ATPase activity seem to be positively correlated with the birth weight (P < 0.05). On the basis of our observation, it is believed that the Huoxuequyu decoction could increase erythrocyte membrane Ca(2+)-ATPase activity and promote blood circulation, thereby exerting a beneficial effect on fetal development.
Chen
Z
Z
Department of Traditional Chinese Medicine, Tongji Hospital, Tongji Medical University, Wuhan.
Shu
H Y
HY
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000201:enzymology*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D004365:Drugs, Chinese Herbal; D014028:Tobacco Smoke Pollution; D000252:Calcium-Transporting ATPases