Adhesion to laminin is down-regulated upon retinoic acid-induced F9 cell differentiation: a role for alpha 6/beta 1 integrin.
F9 mouse teratocarcinoma cells have a high capacity to adhere to laminin and we identified alpha 6/beta 1 integrin as the principal laminin-binding protein present in these cells. F9 cells differentiated into parietal endoderm when monolayer cultures were treated with retinoic acid and dibutyryl cyclic AMP. In this process a decreased adherence to laminin was observed due to a lower expression of alpha 6/beta 1 integrin on the cell surface.
Elias
M C
MC
Instituto Ludwig de Pesquisa sobre o Câncer, São Paulo, Brasil.
Chammas
R
R
Giorgi
R R
RR
Frochtengarten
F
F
Santos
C L
CL
Brentani
R R
RR
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002448:Cell Adhesion; D002454:Cell Differentiation / Q000187:drug effects; D015536:Down-Regulation; D039121:Integrin alpha6beta1; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D007797:Laminin / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D011485:Protein Binding; D017474:Receptors, Laminin / Q000378:metabolism / Q000502:physiology*; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D039121:Integrin alpha6beta1; D016023:Integrins; D007797:Laminin; D017474:Receptors, Laminin; D014212:Tretinoin; D003994:Bucladesine