Mycobacterial polar glycopeptidolipids enhance resistance to experimental murine candidiasis.
Intraperitoneal administration of polar glycopeptidolipids extracted from Mycobacterium chelonae (pGPL-Mc) greatly increased the resistance of mice against a lethal disseminated Candida albicans infection. This enhanced resistance was demonstrated by an increase in the number of survivors and the prolongation of the mean survival time of animals following a lethal challenge. These effects were dependent upon the infective dose of Candida albicans, the dose of pGPL-Mc and the timing of its administration. This enhanced resistance was correlated with the development and persistence of a hyperleukocytosis, associated with a long lasting increase in the number of polymorphonuclear neutrophils. On the contrary, no candidacidal effect of the serum collected from pretreated mice was observed; suggesting that the ability of pGPL-Mc to increase resistance against Candida albicans infection is likely to be mediated by polymorphonuclear neutrophils. These results confirm previously described immunostimulating properties of pGPL-Mc and open the way for the evaluation of its effect in the prevention of opportunistic infections in neutropenic patients.
Lagrange
P H
PH
Service de microbiologie, Hôpital Saint-Louis, Paris, France.
Fourgeaud
M
M
Neway
T
T
Pilet
C
C
D000276:Adjuvants, Immunologic; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006017:Glycolipids / Q000494:pharmacology*; D006020:Glycopeptides / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007964:Leukocytosis / Q000188:drug therapy; D051379:Mice; D016926:Mycobacterium chelonae / Q000737:chemistry*; D016019:Survival Analysis
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006017:Glycolipids; D006020:Glycopeptides; C010762:peptidoglycolipids