[The therapeutic potentials of Ditec in bronchial asthma patients].
Ditec effects on clinicofunctional status were investigated in 15 patients with mild and moderate atopic bronchial asthma (ABA) aged 20-50 (5 males and 10 females). A single ditec dose had a broncholytic effect along the entire bronchial tree and reduced sensitivity to acetylcholine. Magnesium sulfate (a single dose 3 mmol Mg2+, pH 6.6, the solution osmolality 260 mmol/l) potentiated ditec action on nonspecific hyperreactivity of the bronchial tree. Four-week ditec course induced no considerable changes in bronchial permeability, but increased reversibility of bronchial obstruction, inhibited sensitivity and response of the bronchial tree to acetylcholine. Course administration of ditec lowered endobronchial concentration of histamine and lipid peroxidation intensity showing antiallergic and antiinflammatory properties of the drug. Ditec is recommended for ABA and other asthma forms treatment as a safe and effective modality.
Fedoseev
G B
GB
Emel'ianov
A V
AV
Sinitsina
T M
TM
Goncharova
V A
VA
D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000503:physiopathology; D001985:Bronchial Provocation Tests / Q000379:methods; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012119:Respiration / Q000187:drug effects
D000336:Aerosols; D004338:Drug Combinations; C078581:ditec; D005280:Fenoterol; D004205:Cromolyn Sodium; D000420:Albuterol
Terapevticheskie vozmozhnosti ditéka u bol'nykh bronkhial'noĭ astmoĭ.