Red cell alloimmunization after a bone allograft.
BACKGROUND
Alloimmunization to blood group antigens other than ABH after bone allografting is uncommon. To date, examples of alloimmunization to blood group antigens other than ABH have been limited to the Rh system.


METHODS
A 20-year-old woman received an allogeneic bone graft following resection of an osteosarcoma. The patient had received no blood components and denied any pregnancies. Alloimmunization was detected and alloantibodies were identified by standard serologic techniques. Fourteen months after the bone graft, anti-Fya and anti-Jkb were identified in her serum.


CONCLUSIONS
Alloimmunization to blood group antigens other than ABO and Rh may follow bone allografting.
Cheek
R F
RF
Department of Pathology, Massachusetts General Hospital, Boston, USA.
Harmon
J V
JV
Stowell
C P
CP
D000293:Adolescent; D001789:Blood Group Antigens / Q000276:immunology*; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D012516:Osteosarcoma / Q000601:surgery*
D001789:Blood Group Antigens; D007518:Isoantibodies