Gastrointestinal blood loss induced by three different non-steroidal anti-inflammatory drugs.
A clinical study was performed on 18 healthy volunteers to compare the gastrointestinal daily blood loss induced by oral intake of three different non-steroidal anti-inflammatory drugs, lysine clonixinate (CAS 55837-30-4), ibuprofen (CAS 15687-27-1) and acetylsalicylic acid (CAS 50-78-2 ASA). For quantitative determination of gastrointestinal blood loss, autologous erythrocytes were radiolabelled in vitro with 51Cr and reinfused at study start. The amount of radioactivity excreted in faeces was measured during a placebo baseline phase of three days, a treatment phase of five days with thrice daily dosing of ASA, ibuprofen or lysine clonixinate and a subsequent wash-out phase of five days. The highest increase of mean daily blood loss over baseline was observed after treatment with ASA (+ 1.66 ml/d versus baseline). Treatment with ibuprofen led to an increase of mean daily blood loss by + 0.52 ml/d. During treatment with lysine clonixinate the mean increase of daily blood loss was +0.32 ml/d versus baseline. In the ibuprofen and lysine clonixinate treatment groups the values of mean daily blood loss decreased during the wash-out phase with respect to the verum phase, whereas the mean daily blood loss during the wash-out phase after treatment with ASA even increased in comparison to the verum phase (mean daily blood loss: +2.07 ml/d versus baseline.
Bidlingmaier
A
A
L.A.B. GmbH & Co(d), Buenos Aires, Argentina.
Hammermaier
A
A
Nagyiványi
P
P
Pabst
G
G
Waitzinger
J
J
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D001241:Aspirin / Q000633:toxicity; D002860:Chromium Radioisotopes; D003002:Clonixin / Q000031:analogs & derivatives / Q000633:toxicity; D016861:Cyclooxygenase Inhibitors / Q000633:toxicity; D004912:Erythrocytes / Q000378:metabolism; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007052:Ibuprofen / Q000633:toxicity; D008239:Lysine / Q000031:analogs & derivatives / Q000633:toxicity; D008297:Male; D008875:Middle Aged; D009780:Occult Blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002860:Chromium Radioisotopes; D016861:Cyclooxygenase Inhibitors; C089163:lysine clonixinate; D008239:Lysine; D001241:Aspirin; D003002:Clonixin; D007052:Ibuprofen