[Value of monoclonal antibodies (PC 10, MIB1, p53 and LeuM 1) for assessing the prognosis of patients with squamous epithelial carcinoma of the larynx after partial laser resection].
An immunohistochemical analysis with monoclonal antibodies against Ki-67 (MIB 1), PCNA (PC10), p53 and Lewis X antigen was performed on 47 squamous carcinomas of the larynx after partial laser resection. Ki-67 index and expression of Lewis X antigen correlated significantly with both tumor recurrence rate and tumor-free interval. A much weaker relationship was found for the expression of proliferating cell nuclear antigen (PCNA), and no correlation existed with p53 expression. In conclusion, examination of Ki-67 and Lewis X antigen is thought to provide useful prognostic information concerning laser-resectable squamous carcinomas of the larynx.
Hake
R
R
Institut für Pathologie, Universität zu Köln.
Eckel
H
H
von Pritzbuer
E
E
Volling
P
P
Thiele
J
J
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007830:Larynx / Q000473:pathology; D053685:Laser Therapy; D016256:Lewis X Antigen / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016256:Lewis X Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53
Wertigkeit monoklonaler Antikörper (PC 10,MIB 1,p53 und LeuM 1) für die Abschätzung der Prognose von Patienten mit Plattenepithelkarzinomen des Larynx nach Laserteilresektion.