title: Supply and transport of peptides presented by class I MHC molecules.
abstract: Three observations suggest that the proteasome, transporter associated with antigen processing (TAP) and class I MHC molecules are co-adapted for the generation, transport and loading of specific peptides. Firstly, TAP preferentially transports peptides close in length to the optimum for class I loading; secondly, genetic variation in TAP specificity focusing in the carboxy-terminal of the peptide correlates with preferences among class I molecules for different peptide carboxy-termini; thirdly, TAP associates directly with empty class I molecules and is released by successful peptide loading. This conclusion puts in question the significance for class I loading of proteolytic processing and peptide generation in the endoplasmic reticulum.
authors.affiliation: Institute of Genetics, University of Cologne, Germany.
authors.forename: J C
authors.initials: JC
authors.lastname: Howard
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000235:genetics / Q000276:immunology*; D001692:Biological Transport; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000493:pharmacokinetics*
chemical_list: D015395:Histocompatibility Antigens Class I; D010455:Peptides