title: Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.
abstract: G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Chromosomal mapping of the human genes for the two most recently identified members of the GRK family, GRK5 (GPRK5) and GRK6 (GPRK6), was accomplished by correlation of the presence of the GPRK5 and GPRK6 loci with specific chromosome regions in a rodent-human hybrid panel. These analyses revealed that GPRK5 maps to chromosome region 10q24-->qter while GPRK6 maps to 5q35. A GPRK6 related locus maps to 13pter-->q21.
authors.affiliation: Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: F
authors.initials: F
authors.lastname: Bullrich
authors.forename: T
authors.initials: T
authors.lastname: Druck
authors.forename: P
authors.initials: P
authors.lastname: Kunapuli
authors.forename: J
authors.initials: J
authors.lastname: Gomez
authors.forename: K W
authors.initials: KW
authors.lastname: Gripp
authors.forename: B
authors.initials: B
authors.lastname: Schlegelberger
authors.forename: J
authors.initials: J
authors.lastname: Lasota
authors.forename: M
authors.initials: M
authors.lastname: Aronson
authors.forename: L A
authors.initials: LA
authors.lastname: Cannizzaro
authors.forename: K
authors.initials: K
authors.lastname: Huebner
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D002895:Chromosomes, Human, Pair 5; D006224:Cricetinae; D003412:Cricetulus; D017931:DNA Primers; D005260:Female; D054774:G-Protein-Coupled Receptor Kinase 5; D054768:G-Protein-Coupled Receptor Kinases; D019204:GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010920:Placenta / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D017346:Protein Serine-Threonine Kinases; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D017931:DNA Primers; D020794:Receptor Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D054774:G-Protein-Coupled Receptor Kinase 5; D054768:G-Protein-Coupled Receptor Kinases; C089176:G-protein-coupled receptor kinase 6; C517898:GRK5 protein, human; D019204:GTP-Binding Proteins