The role of HLA antigens as indicators of disease progression in psoriatic arthritis. Multivariate relative risk model.
OBJECTIVE
To identify HLA markers for the development of severe disease in psoriatic arthritis (PsA).


METHODS
Patients with PsA who were followed up prospectively over a 14-year period were included. Clinical and laboratory assessments of both active inflammation and clinical damage were performed at 6-month intervals according to a standard protocol, which also included serologic HLA typing for class I and II antigens. Progression of damage was defined as transition into higher damage states, defined by the number of damaged joints. Both univariate and multivariate models were developed to identify predictors for progression of damage.


RESULTS
Univariate analysis revealed that the HLA antigens B27, B39, and DQw3 were associated with disease progression, while HLA-DR7 was "protective." The best multivariate model identified the HLA antigens B27, when DR7 was present, and DQw3, when DR7 was not present, as predicting disease progression across all transitions, while HLA-B39 was associated with progression in early disease. The addition of these HLA indicators to a model containing clinical variables resulted in a significant improvement in fit.


CONCLUSIONS
The HLA antigens associated with PsA, B27 and B39, are risk factors for disease progression, as is the HLA class II antigen DQw3. In combination with clinical measures of disease, these HLA variables are the dominant predictors of progression.
Gladman
D D
DD
University of Toronto, Ontario, Canada.
Farewell
V T
VT
D000293:Adolescent; D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000276:immunology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000378:metabolism / Q000502:physiology; D015235:HLA-B Antigens / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D015796:HLA-B27 Antigen / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D059946:HLA-B39 Antigen; D006683:HLA-DQ Antigens / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D015809:HLA-DR7 Antigen / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007596:Joints / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
D006680:HLA Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D059946:HLA-B39 Antigen; D006683:HLA-DQ Antigens; C051569:HLA-DQ3 antigen; D015809:HLA-DR7 Antigen