title: [Two-stage multivariant analyses for prediction of hepatic function reserve].
abstract: Eleven liver function tests were used for preoperative estimations of the hepatic function reserve in 103 patients with primary hepatocellular carcinoma (HCC) and underlying liver cirrhosis. Postoperatively, the patients' liver function could be classified as good recovering (Grade A, n = 38), functional damage (Grade B, n = 37) and liver failure (Grade C, n = 28). Single factor analyses showed 6 of those tests were significant indicators, including the ratio of blood glucose level at 120 minutes and 60 minutes by oral glucose tolerance test, total bilirubin, the ratio of albumin and globulin, prealbumin, prothrombin time and indocyanine green retention at 15 minutes. The correlations between 11 preoperative parameters (xi) and postoperative course scored (Y) were analysed by Fisher's discriminant test. The multiple regression equation Y1 was obtained by comparing from groups of Grade A with B and formula Y2 from groups of Grade B with C. The predictive accuracy of both equations were 88.0%, 83.1%, respectively. To select adequate surgical procedures with the best therapeutic effect and minimal liver damage for the patients with HCC, we proposed a method of "two-stage predications" combining use of Y1 and Y2 for evaluation of liver function reserve.
authors.affiliation: First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou.
authors.forename: M D
authors.initials: MD
authors.lastname: Lu
authors.forename: J F
authors.initials: JF
authors.lastname: Huang
authors.forename: B G
authors.initials: BG
authors.lastname: Peng
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000503:physiopathology* / Q000601:surgery; D016002:Discriminant Analysis; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000503:physiopathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011228:Prealbumin / Q000378:metabolism
chemical_list: D011228:Prealbumin