AKD-2A, B, C and D, new antibiotics from Streptomyces sp. OCU-42815. Taxonomy, fermentation, isolation, structure elucidation and biological activity.
An antibiotic complex, AKD-2, was isolated from the mycelial cake of Streptomyces sp. OCU-42815. The lipophilic substances in this complex were further purified by a recycling HPLC procedure and were designated AKD-2A, C and D. AKD-2B was obtained as a mixture of AKD-2B1 and AKD-2B2. These substances were identified as monoglycerides having branched chain fatty acids and exhibited both antibacterial and antifungal activities.
Akeda
Y
Y
Faculty of Science, Osaka City University, Japan.
Shibata
K
K
Ping
X
X
Tanaka
T
T
Taniguchi
M
M
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005989:Glycerides / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013302:Streptomyces; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D005989:Glycerides