title: Ontogenesis of melatonin receptors in anterior pituitary and pars tuberalis of golden hamsters.
abstract: The ontogenesis of melatonin receptors in the anterior pituitary and pars tuberalis of the Golden hamster was studied using [125I]iodomelatonin as a ligand. The affinity of the binding site to the ligand (Kd) was in the range 21 to 54 pM and it did not change significantly during development. The concentration of the [125I]iodomelatonin binding sites in the anterior pituitary was highest in one-day-old hamsters (Bmax = 14 fmol/mg protein) and thereafter gradually decreased. In adults it reached to about 6% of the neonatal values. In contrast, the concentration of the binding sites in pars tuberalis did not change significantly during ontogenesis and it was in the range of 3 to 5 fmol/mg protein.
authors.affiliation: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
authors.forename: J
authors.initials: J
authors.lastname: Vanĕcek
authors.forename: E
authors.initials: E
authors.lastname: Kosar
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D006224:Cricetinae; D005260:Female; D008297:Male; D008550:Melatonin / Q000378:metabolism / Q000493:pharmacokinetics; D008647:Mesocricetus; D010903:Pituitary Gland, Anterior / Q000254:growth & development* / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D044094:Receptors, Melatonin
chemical_list: D011956:Receptors, Cell Surface; D044094:Receptors, Melatonin; D008550:Melatonin