title: The rash of measles is caused by a viral infection in the cells of the skin: a case report.
abstract: Measles skin rash was immunohistochemically examined in an effort to detect virus antigen in skin samples taken from a 15-year-old girl with measles. A sectioned specimen obtained by punch biopsy from a 2nd-day skin lesion showed localized parakeratosis and acanthosis with multinucleated giant cells in the epidermis, thickening and cellular edema of epithelia in the hair follicles, and vascular dilation in the papillary plexus. Measles virus antigen was detected by ABC immunoperoxidase in the epidermis, follicular epithelia, and lympho-histiocytic cell infiltrates in the upper of the dermis. This rash deemed to be caused in part by direct viral infection of the epidermal cells.
authors.affiliation: Second Department of Dermatology, Toho University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Makino
authors.forename: F
authors.initials: F
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Sata
authors.forename: O
authors.initials: O
authors.lastname: Urushibata
authors.forename: T
authors.initials: T
authors.lastname: Kurata
authors.forename: M
authors.initials: M
authors.lastname: Nishiwaki
mesh_terms: D000293:Adolescent; D000956:Antigens, Viral / Q000032:analysis; D004487:Edema / Q000473:pathology / Q000821:virology; D004817:Epidermis / Q000473:pathology / Q000821:virology; D004848:Epithelium / Q000473:pathology / Q000821:virology; D005260:Female; D015726:Giant Cells / Q000473:pathology / Q000821:virology; D006197:Hair / Q000473:pathology / Q000821:virology; D006644:Histiocytes / Q000473:pathology / Q000821:virology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology / Q000821:virology; D008457:Measles / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008459:Measles virus / Q000276:immunology; D012867:Skin / Q000473:pathology / Q000821:virology*; D014581:Urticaria / Q000473:pathology / Q000821:virology*
chemical_list: D000956:Antigens, Viral