Protective effect of carnitine on lipoperoxide formation in rat brain.
Carnitine administration (by intraperitoneal injection) to 21-day-old-rats prevents the increase of thiobarbituric acid-reactive substances (index of lipid peroxidation and free radical damage) induced by 30 min hypobaric hypoxia in four different parts of the brain (cerebral cortex, subcortical structures, medulla oblongata and cerebellum).
Koudelová
J
J
Institute of Physiology, First Faculty of Medicine, Charles University, Czech Republic.
Mourek
J
J
Drahota
Z
Z
Rauchová
H
H
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002331:Carnitine / Q000097:blood / Q000494:pharmacology*; D005260:Female; D002534:Hypoxia, Brain / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D017392:Thiobarbituric Acid Reactive Substances; D002331:Carnitine