Determination of octanol-water partition coefficients by an HPLC method for anticonvulsant structure-activity studies.
Octanol-water partition coefficients have been measured and calculated for eight clinically relevant anticonvulsants. For some compounds, these are the first experimentally available log P values. For the remainder of the molecules, new values have been suggested. The utility of the micro shake-flask experimental method and the ALOGP calculational method in determining anticonvulsant log P values has been demonstrated.
Henczi
M
M
Department of Chemistry, Queen's University, Kingston, Canada.
Nagy
J
J
Weaver
D F
DF
D020003:1-Octanol; D000927:Anticonvulsants / Q000737:chemistry* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D000442:Octanols; D012995:Solubility; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D000442:Octanols; D020003:1-Octanol