title: Ischemic optic neuropathy and high-level anticardiolipin antibodies in primary Sjögren's syndrome.
abstract: A 39-year-old woman with recurrent severe anterior ischemic optic neuropathy in the setting of Sjögren's syndrome was found to have high-titer IgM anticardiolipin antibodies (aCL) that were enhanced by the phospholipid-binding glycoprotein beta 2GP1. The recognition of IgM aCL-associated vasculopathy as a possible etiologic factor in the optic neuropathy in Sjögren's syndrome may be relevant in deciding appropriate therapy.
authors.affiliation: LSU Medical Center, Department of Medicine, Section of Rheumatology in New Orleans 70112-2822, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Rosler
authors.forename: M D
authors.initials: MD
authors.lastname: Conway
authors.forename: J M
authors.initials: JM
authors.lastname: Anaya
authors.forename: J F
authors.initials: JF
authors.lastname: Molina
authors.forename: R F
authors.initials: RF
authors.lastname: Carr
authors.forename: A E
authors.initials: AE
authors.lastname: Gharavi
authors.forename: W A
authors.initials: WA
authors.lastname: Wilson
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D009901:Optic Nerve Diseases / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology*
chemical_list: D017153:Antibodies, Anticardiolipin