An (A-C)n dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients.
To study the relationship between the aldose reductase gene and diabetic complications, an (A-C)n dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygosity of 0.77 among the Chinese population in Hong Kong. One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.
Ko
B C
BC
Institute of Molecular Biology, University of Hong Kong.
Lam
K S
KS
Wat
N M
NM
Chung
S S
SS
D000328:Adult; D017668:Age of Onset; D000449:Aldehyde Reductase / Q000235:genetics*; D001483:Base Sequence; D002681:China / Q000208:ethnology; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D004276:DNA, Satellite / Q000235:genetics; D003920:Diabetes Mellitus / Q000201:enzymology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D006723:Hong Kong; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D012016:Reference Values; D012091:Repetitive Sequences, Nucleic Acid; D012307:Risk Factors
D017931:DNA Primers; D004276:DNA, Satellite; D004247:DNA; D000449:Aldehyde Reductase