title: [Serial assessment of MIBG scintigraphy in a case of DCM with heart failure improved by beta-blocker therapy].
abstract: We experienced a case of DCM (62-year-old man) improved by beta-blocker (Metoprolol) therapy and studied time course of MIBG scintigraphy. We measured cardiac functions by UCG and 99mTc cardiac pool imaging, and MIBG scintigraphy during 12 months of beta-blocker therapy. In planar images we measured washout rate (WR) in total myocardium and regional washout rate (rWR) in 6 segments of myocardium. Cardiac function improved after 3 months of therapy. The WR did not improve until 6 months, but improved after 9 months (Before: 35.1%, 3 months after: 34.6%, 6 months after: 33.6%, 9 months after: 27.6%, 12 months after: 25.4%). rWR in inferoapical segment first improved at 3 months (Before: 40.1%, 3 months after: 35.1%), whereas rWR in antero-apical segment improved after 6 months and that in anterior segment improved after 9 months. These results suggest that the improvement of cardiac sympathetic nerve function in DCM treated with beta-blocker was not identical in each myocardium region.
authors.affiliation: Division of Internal Medicine, Shinsenri Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Asada
authors.forename: T
authors.initials: T
authors.lastname: Yabunouchi
authors.forename: R
authors.initials: R
authors.lastname: Morozumi
authors.forename: H
authors.initials: H
authors.lastname: Kusuoka
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D019797:3-Iodobenzylguanidine; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging*; D006333:Heart Failure / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage*; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011877:Radionuclide Imaging
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine; D008790:Metoprolol