title: The synthesis of novel HIV-protease inhibitors.
abstract: The syntheses, enzyme inhibition and antiviral activity of potent HIV-protease inhibitors containing novel beta-hydroxy ether and thioethers based on the transition state mimetic concept are discussed.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
authors.forename: V M
authors.initials: VM
authors.lastname: Girijavallabhan
authors.forename: F
authors.initials: F
authors.lastname: Bennett
authors.forename: N M
authors.initials: NM
authors.lastname: Patel
authors.forename: A K
authors.initials: AK
authors.lastname: Ganguly
authors.forename: B
authors.initials: B
authors.lastname: Dasmahapatra
authors.forename: N
authors.initials: N
authors.lastname: Butkiewicz
authors.forename: A
authors.initials: A
authors.lastname: Hart
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D015497:HIV-1 / Q000187:drug effects; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004987:Ethers; D017320:HIV Protease Inhibitors; D013440:Sulfides