title: Autologous blood instillation alters respiratory mechanics in horses.
abstract: To investigate physiological consequences of autologous blood instillation in the lungs of healthy horses, respiratory mechanics and bronchial response to histamine were studied in 8 Thoroughbreds before and after introducing autologous blood (n = 5) and sterile saline solution (n = 3) into their lungs. Blood instillation resulted in a decrease in dynamic compliance (Cdyn) and increased respiratory resistance (R). Bronchial sensitivity and reactivity were unchanged after blood introduction. There were no significant changes in pulmonary mechanics or bronchial response after saline instillation.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: E
authors.initials: E
authors.lastname: Aguilera-Tejero
authors.forename: J R
authors.initials: JR
authors.lastname: Pascoe
authors.forename: W S
authors.initials: WS
authors.lastname: Tyler
authors.forename: M J
authors.initials: MJ
authors.lastname: Woliner
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001804:Blood Transfusion, Autologous; D001985:Bronchial Provocation Tests / Q000662:veterinary; D005260:Female; D006470:Hemorrhage / Q000503:physiopathology / Q000662:veterinary*; D006632:Histamine; D006734:Horse Diseases / Q000503:physiopathology*; D006736:Horses; D008171:Lung Diseases / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*
chemical_list: D006632:Histamine