Medical treatment of West syndrome in Japan.
Although corticotropin (ACTH) is still the most effective drug for the treatment of West syndrome, a variety of other treatment modalities have been tried because of corticotropin's frequent and sometimes serious side effects. A recent survey on the treatment of this devastating disorder by Japanese child neurologists disclosed different therapeutic approaches from those taken by American or European child neurologists. Most Japanese child neurologists use vitamin B6 as the first agent and corticotropin as the third or second drug. Moreover, the dosage of corticotropin used by them is considerably smaller. Therefore, the current status of medical treatment of West syndrome is reviewed, especially comparing Japan with other countries.
Watanabe
K
K
Department of Pediatrics, Nagoya University School of Medicine, Japan.
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage* / Q000009:adverse effects; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D003431:Cross-Cultural Comparison; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007223:Infant; D007564:Japan; D011736:Pyridoxine / Q000008:administration & dosage* / Q000009:adverse effects; D013036:Spasms, Infantile / Q000188:drug therapy*
D000927:Anticonvulsants; D000324:Adrenocorticotropic Hormone; D011736:Pyridoxine