title: The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event.
abstract: We have recently identified a common ALL patient which harboured a chromosomal fusion between the TEL gene on chromosome 12 and the ABL gene on chromosome 9. We designed an RT-PCR assay to screen 186 adult ALL and 30 childhood ALL patients for this novel translocation. We were unable to identify any additional cases with a TEL/ABL fusion product.
authors.affiliation: Department of Paediatrics II, University of Ulm, Germany.
authors.forename: J W
authors.initials: JW
authors.lastname: Janssen
authors.forename: S A
authors.initials: SA
authors.lastname: Ridge
authors.forename: P
authors.initials: P
authors.lastname: Papadopoulos
authors.forename: F
authors.initials: F
authors.lastname: Cotter
authors.forename: W D
authors.initials: WD
authors.lastname: Ludwig
authors.forename: C
authors.initials: C
authors.lastname: Fonatsch
authors.forename: H
authors.initials: H
authors.lastname: Rieder
authors.forename: W
authors.initials: W
authors.lastname: Ostertag
authors.forename: C R
authors.initials: CR
authors.lastname: Bartram
authors.forename: L M
authors.initials: LM
authors.lastname: Wiedemann
mesh_terms: D000328:Adult; D001483:Base Sequence; D002648:Child; D002881:Chromosomes, Human, Pair 12; D002899:Chromosomes, Human, Pair 9; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D016313:Genes, abl; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics*; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D004268:DNA-Binding Proteins; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D014157:Transcription Factors; D000097764:ETS Translocation Variant 6 Protein