title: Adhesion to laminin is down-regulated upon retinoic acid-induced F9 cell differentiation: a role for alpha 6/beta 1 integrin.
abstract: F9 mouse teratocarcinoma cells have a high capacity to adhere to laminin and we identified alpha 6/beta 1 integrin as the principal laminin-binding protein present in these cells. F9 cells differentiated into parietal endoderm when monolayer cultures were treated with retinoic acid and dibutyryl cyclic AMP. In this process a decreased adherence to laminin was observed due to a lower expression of alpha 6/beta 1 integrin on the cell surface.
authors.affiliation: Instituto Ludwig de Pesquisa sobre o Câncer, São Paulo, Brasil.
authors.forename: M C
authors.initials: MC
authors.lastname: Elias
authors.forename: R
authors.initials: R
authors.lastname: Chammas
authors.forename: R R
authors.initials: RR
authors.lastname: Giorgi
authors.forename: F
authors.initials: F
authors.lastname: Frochtengarten
authors.forename: C L
authors.initials: CL
authors.lastname: Santos
authors.forename: R R
authors.initials: RR
authors.lastname: Brentani
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002448:Cell Adhesion; D002454:Cell Differentiation / Q000187:drug effects; D015536:Down-Regulation; D039121:Integrin alpha6beta1; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D007797:Laminin / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D011485:Protein Binding; D017474:Receptors, Laminin / Q000378:metabolism / Q000502:physiology*; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D039121:Integrin alpha6beta1; D016023:Integrins; D007797:Laminin; D017474:Receptors, Laminin; D014212:Tretinoin; D003994:Bucladesine