[Pulmonary emboli of skin and hair particles after intravenous injections].
Among 1422 Sprague-Dawley rats treated daily for 28 consecutive days by i.v. injections, 779 animals (55.8%) showed lesions at the site of injection. 381 rats (26.8%) had pulmonary emboli with fragments of hair or skin in arterial thrombi or in giant cell granulomas. 6 weeks after cessation of treatment lesions were still found in lungs from 5 of 90 rats (5.6%) allowed to recover. In 8 of 64 Himalayan rabbits (12.5%) given 28 injections into ear veins pulmonary embolism was observed. Among 184 rhesus and cynomolgus monkeys treated daily for 28 consecutive days by injection into cephalic or saphenous veins, 167 monkeys (91%) showed lesions at the site of injection, 14 animals (7.6%) had pulmonary emboli with fragments of hair and skin in arterial thrombi or giant cell granulomas.
Kast
A
A
Nippon Boehringer Ingelheim Co., Ltd.
D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D006197:Hair; D007275:Injections, Intravenous / Q000009:adverse effects / Q000662:veterinary*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000209:etiology; D011655:Pulmonary Embolism / Q000209:etiology / Q000662:veterinary*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D012376:Rodent Diseases / Q000209:etiology; D012867:Skin
Lungenembolien von Haut- und Haarteilchen nach intravenöser Injektion.