Cyclosporins from Tolypocladium terricola.
New natural cyclosporins were isolated from the mycelium of surface cultivated fungus Tolypocladium terricola. The chemical structures of [Leu4] CS and [MeLeu1] CS = cyclosporin-J, were deduced from the NMR and mass spectral data. Biological activity of new cyclosporins is reported based on the proliferative mitogen stimulation test.
Jegorov
A
A
Galena Co., Research Unit, Ceske Budĕjovice, Czech Republic.
Matha
V
V
Sedmera
P
P
Havlícek
V
V
Stuchlík
J
J
Seidel
P
P
Simek
P
P
D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003524:Cyclosporins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D003904:Mitosporic Fungi / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013057:Spectrum Analysis
D003524:Cyclosporins