[Rectal administration of ash bark].
A TLC-densitometric method was applied to determine aesculin in rabbit blood. The best way for ash bark rectal administration was found by orthogonal design [L4(2(3))]. The two routes of administration (per rectal, P.O.) were compared by bioavailabilities and the result indicated that per rectal was better than P.O. Modified isolated rectum-bag method was applied successfully to finding the best way for rectal administration of ash bark.
Tan
Y
Y
Jiangxi Institute of Traditional Chinese Medicine, Nanchang.
Lu
W
W
Zhao
S
S
Hu
Y
Y
Ma
Z
Z
D000285:Administration, Rectal; D000818:Animals; D002855:Chromatography, Thin Layer; D003720:Densitometry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004929:Esculin / Q000097:blood; D005260:Female; D008297:Male; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D004929:Esculin