[Local chemotherapy by a sustained-release preparation with fibrin seal against the operative wound in head and neck cancer].
Fibrin seal has been used for hemostasis and sealing in operative field of tumors in the head and neck. The authors applied it for drug preparation and tried a local chemotherapy to treat residual and disseminated tumors of cellular level in the operative wound using 5-FU. The drug release rate in this therapy in vitro study was 50% after 24 hrs. When injected to rats bearing Yoshida sarcoma, it exhibited a marked antitumor effect compared to the control group given 5-FU alone. This therapy is easy to make the dosage adjustment and can apply drugs directly to the tumor residue at the high concentration. It will be clinically a useful adjuvant therapy for radiotherapy, surgery or chemotherapy.
Kubota
T
T
Dept. of Otorhinolaryngology, Fujigaoka Hospital, Showa University.
Matsui
K
K
Ohtani
M
M
Takasaki
S
S
D000818:Animals; D003692:Delayed-Action Preparations; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D005472:Fluorouracil / Q000008:administration & dosage*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D012517:Sarcoma, Yoshida / Q000188:drug therapy / Q000473:pathology
D003692:Delayed-Action Preparations; D015718:Fibrin Tissue Adhesive; D005472:Fluorouracil