title: Case report: psychosis associated with hepatitis B.
abstract: An acute disintegrative disorder in a child with acute hepatitis B virus (HBV) infection is described. Both hepatitis B surface antigen (HBsAg) and HBV-DNA were detected in cerebrospinal fluid (CSF) by means of enzyme-linked immunosorbent assay (ELISA) and the polymerase chain reaction (PCR) technique respectively. A markedly elevated level of CSF adenylate kinase (AK), which normalised as the patient recovered spontaneously, suggested an organic brain disorder. Demonstration of intra-blood-brain barrier production of IgG supported the possibility of local infection by HBV within the central nervous system.
authors.affiliation: Department of Paediatrics and Child Health, University of Stellenbosch, Faculty of Medicine, Tygerberg, South Africa.
authors.forename: H C
authors.initials: HC
authors.lastname: Weber
authors.forename: J F
authors.initials: JF
authors.lastname: Schoeman
authors.forename: A
authors.initials: A
authors.lastname: Nowitz
authors.forename: M L
authors.initials: ML
authors.lastname: Becker
mesh_terms: D000263:Adenylate Kinase / Q000134:cerebrospinal fluid; D002675:Child, Preschool; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D006509:Hepatitis B / Q000134:cerebrospinal fluid / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000134:cerebrospinal fluid; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000821:virology; D012075:Remission, Spontaneous
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D000263:Adenylate Kinase