title: High progesterone levels adversely affect embryo quality and pregnancy rates in in vitro fertilization and oocyte donation programs.
abstract: OBJECTIVE
  To assess the effect of P levels on oocyte and embryo quality and pregnancy rates (PRs) in IVF and oocyte donation.
  
  
  METHODS
  Retrospective analysis of PRs in ovum donors and their recipients with regard to P levels on day of hCG administration.
  
  
  METHODS
  In Vitro Fertilization Units, oocyte donation programs.
  
  
  METHODS
  In vitro fertilization patients who agreed to donate oocytes were treated by hMG alone (53 cycles) or in combination with a GnRH analog (122 cycles).
  
  
  METHODS
  Uterine preparation in oocyte recipients consisted of 6 mg/d E2 valerate. Progesterone (100 mg/d) was added when oocytes became available. Hormonal treatment was continued until 12 weeks of gestation.
  
  
  RESULTS
  Using a series of Fisher's Exact Tests, a critical threshold for P was identified at 1.9 ng/mL (conversion factor to SI units, 3.185). With elevated P levels (> 1.9 ng/mL), lower PRs were noted for the donors (7.1% versus 17%), as well for the recipients (8.3% versus 26.7%).
  
  
  CONCLUSIONS
  Exposure to elevated P levels resulted in lower PRs for the donors and significantly lower PRs in the recipients. Because the endometria in the recipients were prepared uniformly, we conclude that this is the result of detrimental effects of P on oocyte or embryo quality.
authors.affiliation: In Vitro Fertilization-Embryo Transfer Unit, Serlin Maternity Hospital, Tel Aviv, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Yovel
authors.forename: Y
authors.initials: Y
authors.lastname: Yaron
authors.forename: A
authors.initials: A
authors.lastname: Amit
authors.forename: M R
authors.initials: MR
authors.lastname: Peyser
authors.forename: M P
authors.initials: MP
authors.lastname: David
authors.forename: A
authors.initials: A
authors.lastname: Kogosowski
authors.forename: J B
authors.initials: JB
authors.lastname: Lessing
mesh_terms: D000328:Adult; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D018587:Oocyte Donation; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D011374:Progesterone