Multisensory convergence and integration in the neostriatum and globus pallidus of the rat.
The extracellular response properties of neurons in the caudate-putamen (CPu), globus pallidus (GP) and lateral amygdaloid nucleus (La) evoked by auditory and somatosensory stimuli were investigated. A total of 61 neurons in these areas responded either singly to somatosensory stimulation (unisensory), or to both somatosensory and auditory stimulation (multisensory). Higher rates of somatosensory stimulation reduced the response magnitude of CPu neurons more than that of GP neurons. In multisensory neurons, combined somatosensory and auditory stimulation compared to unisensory stimulation resulted in three characteristic response patterns: enhancement, depression or interaction. Temporal misalignment of the peak frequency latencies evoked by auditory and somatosensory stimulation altered the response magnitude in the majority of neurons. The response properties and anatomical connectivity of CPu and GP neurons suggest that the observed multisensory integrative effects may be used to facilitate motor responses to low intensity stimuli.
Chudler
E H
EH
Department of Anesthesiology and Multidisciplinary Pain Center RN-10, University of Washington, Seattle 98195, USA.
Sugiyama
K
K
Dong
W K
WK
D000161:Acoustic Stimulation; D000679:Amygdala / Q000166:cytology / Q000502:physiology; D000818:Animals; D001306:Auditory Pathways / Q000166:cytology / Q000502:physiology; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D004558:Electric Stimulation; D005917:Globus Pallidus / Q000166:cytology / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012677:Sensation / Q000502:physiology*