T cell receptor iota an alternatively spliced product of the T cell receptor zeta gene.
It has been previously suggested that three alternative splicings of the murine T cell receptor (TCR) zeta gene are involved in the regulation of TCR/CD3 transduction signals. We here describe a new alternative splicing of this gene (TCR iota), cloned by reverse transcriptase-polymerase chain reaction, that is encoded by exons 1-7 and 10. The protein putatively encoded by TCR iota mRNA differs in its carboxy terminus from that coded by TCR0 as a consequence of the reading frame shift of exon 10. The possible role of this new splicing in TCR modulation is briefly discussed.
Nocentini
G
G
Department of Clinical Medicine, University of Perugia, Medical School, Italy.
Ronchetti
S
S
Bartoli
A
A
Testa
G
G
D'Adamio
F
F
Riccardi
C
C
Migliorati
G
G
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics*; D005796:Genes; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012326:RNA Splicing; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell; C094053:antigen T cell receptor, iota chain; C054979:antigen T cell receptor, zeta chain