title: [Essential thrombocythemia--clinical course from personal material].
abstract: The article presents clinical course analysis of essential thrombocythemia in 17 patients aged 29-82. The diagnostic criteria were the same as described by Polycythemia Vera Study Group. Mean platelet level of diagnosis was 1680 x 10(9)/l. Haemorrhagic complications were observed in 42% of the patients, while thrombotic ones or embolisms in 35%. In two cases both types of complications occurred. Asymptomatic course of the disease was observed in 5 patients. The statistical analysis proved that the patients with platelet count between 900-1900 x 10(9)/l are in danger of developing thrombotic episodes and thus antiaggregation treatment should be considered. If platelet level exceeds 1900 x 10(9)/l the risk of haemorrhage increases, so antiaggregation treatment is contraindicated and thrombocytapheresis is advised instead. The patients was started on treatment when platelet count was above 1000 x 10(9)/l in asymptomatic cases or with lower platelet level in symptomatic ones. The treatment consisted of busulphan, hydroxyurea or interferon alpha (in one of the patients) until lowering platelet level below 600 x 10(9)/l.
authors.affiliation: Kliniki Hematologii I.Ch.W., Akademii Medycznej w Gdańsku.
authors.forename: M
authors.initials: M
authors.lastname: Bieniaszewska
authors.forename: A
authors.initials: A
authors.lastname: Hellmann
authors.forename: J
authors.initials: J
authors.lastname: Kabata
authors.forename: A
authors.initials: A
authors.lastname: Rasze-Ja-Specht
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002066:Busulfan / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013920:Thrombocythemia, Essential / Q000150:complications / Q000628:therapy
chemical_list: D016898:Interferon-alpha; D002066:Busulfan; D006918:Hydroxyurea
vernacular_title: Nadpłytkowość samoistna--analiza przebiegu klinicznego w materiale własnym.