[Hepatic hemodynamic changes in liver cancer patients during intrahepatic arterial angiotensin II infusion induced hypertension and chemoembolization].
In this report, hepatic hemodynamics were studied by pulsed ultrasound doppler during the process of intrahepatic arterial angiotensin II infusion induced hypertension and chemoembolization (IHCE) in 20 liver cancer patients. It was found that at 90 seconds after I-HCE, tumor blood supply increased by an average of 1.786 times while the blood flow of proper hepatic artery decreased to an average of 0.5665 times of its original level. At the same time patients' peripheral blood pressure increased by 3.7kPa. It is evidenced that angiotensin II infusion augments blood flow to tumor region while decreases blood supply in healthy tissues.
Jiang
X Q
XQ
Cancer Center, 81 Hospital of People's Liberation Army, Nangjing.
Yin
G F
GF
Lu
X X
XX
D000804:Angiotensin II / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D016461:Chemoembolization, Therapeutic; D005260:Female; D006439:Hemodynamics; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008102:Liver Circulation / Q000187:drug effects*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D018617:Ultrasonography, Doppler, Pulsed; D014655:Vascular Resistance / Q000187:drug effects
D000804:Angiotensin II