title: Tetracyclines.
abstract: Tetracyclines are relatively safe drugs with a broad antimicrobial spectrum. Doxycycline remains the preferred tetracycline agent for most indications. Doxycycline has a long half-life, which makes convenient twice-a-day dosing possible. It is well absorbed orally even in the presence of food, has excellent tissue penetration, and does not require a dose adjustment in renal insufficiency. Doxycycline is a useful agent for the treatment of atypical pneumonias, sexually transmitted diseases, traveler's diarrhea, rickettsial infections, and Lyme disease. Minocycline is the preferred drug for MRSA colonization/infection.
authors.affiliation: Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, USA.
authors.forename: N C
authors.initials: NC
authors.lastname: Klein
authors.forename: B A
authors.initials: BA
authors.lastname: Cunha
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013753:Tetracycline Resistance; D013754:Tetracyclines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D013754:Tetracyclines