title: Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an orally active anticancer drug.
abstract: The structure of the anticancer drug bis(acetato)-amminedichloro(cyclohexylamine)platinum(IV), [PtCl2-(C2H3O2)2(C6H13N)(NH3)], is reported. The acetato groups are axial to the square plane composed of the chlorine and amine substituents. The cyclohexane ring may sterically hinder one of the acetato groups for metabolic attack. The amine groups are hydrogen bonded to the carbonyl O atoms of the acetato groups.
authors.affiliation: CRC Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, England.
authors.forename: S
authors.initials: S
authors.lastname: Neidle
authors.forename: C F
authors.initials: CF
authors.lastname: Snook
authors.forename: B A
authors.initials: BA
authors.lastname: Murrer
authors.forename: C F
authors.initials: CF
authors.lastname: Barnard
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002712:Chlorides / Q000737:chemistry; D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002712:Chlorides; D009944:Organoplatinum Compounds; C081294:satraplatin