title: A case of Werner's syndrome associated with systemic lupus erythematosus.
abstract: The case of a 40-year-old woman with Werner's syndrome associated with systemic lupus erythematosus (SLE) is reported. The patient exhibited short stature, slender extremities, thinned hair, high-pitched voice, cataracts, ulceration of the fingers, and mental retardation. Malar erythema, photosensitivity, and proteinuria had been noted since age 34. The serum contained high titers of antibodies to dsDNA, Sm, nRNP, and SS-A/Ro. The simultaneous presence of Werner's syndrome and SLE could be a coincidental occurrence of the two diseases, although it might be due to an abnormality in replication or degeneration of DNA leading to the development of both diseases.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical College, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kogure
authors.forename: Y
authors.initials: Y
authors.lastname: Ohshima
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Ohba
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: M
authors.initials: M
authors.lastname: Ohara
authors.forename: T
authors.initials: T
authors.lastname: Nishimaki
authors.forename: R
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology; D001706:Biopsy; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D014898:Werner Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear; D011239:Prednisolone; D008775:Methylprednisolone