DNA aneuploidy in a case of rectosigmoid adenocarcinoma complicated by ulcerative colitis.
A case of Borrmann type IV colorectal adenocarcinoma detected as a complication of long-standing ulcerative colitis is reported. Barium enema and colonoscopy disclosed a stenotic area associated with a tumoral mass and a flat elevated lesion in the rectosigmoid region and a submucosal tumor-like lesion in the rectum. Total colectomy was performed and histological studies demonstrated a moderately differentiated adenocarcinoma accompanied by high- and low-grade dysplasia. DNA ploidy pattern analysis showed aneuploidy in the adenocarcinoma and high-grade dysplasia, but diploidy in the normal and atrophic mucosa and in low-grade dysplasia. DNA aneuploid content was associated with the presence of colorectal carcinoma complicating ulcerative colitis, indicating that DNA content studies should be included in screening programs to detect early colorectal carcinoma following this disease, as a complementary study to histological assessment.
Makiyama
K
K
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Tokunaga
M
M
Itsuno
M
M
Zea-Iriarte
W
W
Hara
K
K
Nakagoe
T
T
D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics*; D000782:Aneuploidy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000209:etiology; D015179:Colorectal Neoplasms / Q000150:complications / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged
D004273:DNA, Neoplasm