title: Contact allergy to gold sodium thiosulfate.
abstract: 278 consecutive patients with suspected contact dermatitis were patch tested with the European standard series and gold sodium thiosulfate (0.5% pet.): 13 patients (4.6%) had a positive allergic response to gold sodium thiosulfate (GST). All of these patients were female, with a mean age of 37 years. The most frequent site of eczema in these patients was the head and neck (62%). A seborrhoeic distribution of eczema was common. 46% had involvement of the limbs, 15% had a perianal or perivulval rash. The mean duration of eczema in this group of patients was 15.8 months. 54% of patients allergic to gold were also allergic to nickel. Biopsy of positive patch test reactions to GST were consistent with allergic contact dermatitis.
authors.affiliation: Department of Dermatology, Royal Victoria Hospitals Trust, Belfast, Northern Ireland, UK.
authors.forename: K E
authors.initials: KE
authors.lastname: McKenna
authors.forename: O
authors.initials: O
authors.lastname: Dolan
authors.forename: M Y
authors.initials: MY
authors.lastname: Walsh
authors.forename: D
authors.initials: D
authors.lastname: Burrows
mesh_terms: D000328:Adult; D001004:Anus Diseases / Q000209:etiology; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D004485:Eczema / Q000209:etiology; D005260:Female; D006047:Gold Alloys / Q000009:adverse effects; D012971:Gold Sodium Thiosulfate / Q000009:adverse effects*; D006682:HLA-DP Antigens / Q000032:analysis; D006683:HLA-DQ Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects; D010328:Patch Tests; D013601:T-Lymphocytes / Q000473:pathology; D014845:Vulvar Diseases / Q000209:etiology
chemical_list: D006047:Gold Alloys; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; C029938:nickel sulfate; D009532:Nickel; D012971:Gold Sodium Thiosulfate