title: Clinical implications of pleomorphic ventricular tachycardias on oral sotalol therapy.
abstract: In 90 consecutive patients with coronary artery disease and sustained monomorphic ventricular tachycardia, who were treated with oral sotalol and underwent programmed stimulation to determine drug effectiveness, the influence of sotalol on induced ventricular tachycardia morphology was retrospectively examined. In 54 patients (60%) sotalol rendered the tachycardia non-inducible. However, contrary to drug-testing with class I antiarrhythmic agents, induction of multiple morphologies at baseline study did not predict failure of subsequent drug-testing with sotalol. In the remaining 36 patients (40%), in whom sotalol did not modify inducibility, 21 patients (i.e. a total of 23%) manifested at least one new morphology during electropharmacological testing on sotalol. This effect was independent of the degree of left ventricular dysfunction, infarct location and numbers of morphologies at baseline, but corresponded with drug-induced changes in refractoriness. This observation may be related to a proarrhythmic effect of sotalol. Slowing of ventricular tachycardia rate and changes in morphology may have implications in patients receiving implantable cardioverter-defibrillators or those undergoing ablative procedures.
authors.affiliation: Hospital of the Westfälische Wilhelms-Universität Münster, Department of Cardiology and Angiology, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Reisinger
authors.forename: M
authors.initials: M
authors.lastname: Shenasa
authors.forename: A
authors.initials: A
authors.lastname: Lubinski
authors.forename: G
authors.initials: G
authors.lastname: Hindricks
authors.forename: W
authors.initials: W
authors.lastname: Haverkamp
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Breithardt
authors.forename: M
authors.initials: M
authors.lastname: Borggrefe
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002304:Cardiac Pacing, Artificial; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy; D013015:Sotalol / Q000008:administration & dosage / Q000009:adverse effects*; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D013015:Sotalol