Antiallergic dimeric prenylbenzoquinones from Ehretia microphylla.
The ethyl acetate-soluble portion of the MeOH extract of Ehretia microphylla showed inhibitory activity on exocytosis in antigen-stimulated rat basophils. The bioassay-guided separation of this fraction afforded five biologically active compounds. By means of chemical and spectroscopic methods, the structures of these compounds, which include microphyllone, a unique dimeric prenylbenzoquinone, and its congeners, were elucidated.
Yamamura
S
S
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
Simpol
L R
LR
Ozawa
K
K
Ohtani
K
K
Otsuka
H
H
Kasai
R
R
Yamasaki
K
K
Padolina
W G
WG
D000485:Allergens; D000818:Animals; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005089:Exocytosis / Q000187:drug effects; D006633:Histamine Antagonists / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010679:Philippines; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000485:Allergens; D016227:Benzoquinones; D006633:Histamine Antagonists