[The principles for creating drug preparations of natural origin that stimulate hematopoiesis].
The paper outlines the principles in designing hemostimulators by using glycosamineglycans. Hemostimulating properties of the tested agents is likely to be primarily due to the presence of D-glucuronic acid in their structure. The homotypic mechanisms are largely responsible for all agents' effect in stimulating hemopoiesis. Thus, they all virtually activate the function of the hemopoiesis-inducing microenvironment. In addition, they directly or indirectly stimulate the processes of proliferation and differentiation of precursor cells of erythro- and granulomonocytopoiesis.
Gol'dberg
E D
ED
Dygaĭ
A M
AM
Agafonov
V I
VI
Aksinenko
S G
SG
Gol'dberg
V E
VE
Zhdanov
V V
VV
Litvinenko
V I
VI
Liubavina
P A
PA
Matiash
M G
MG
Novitskiĭ
E V
EV
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D015195:Drug Design; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship
D006025:Glycosaminoglycans; D010936:Plant Extracts
Printsipy sozdaniia lekarstvennykh preparatov--stimuliatorov krovetvoreniia prirodnogo proiskhozhdeniia.