Effect of iontophoretic patterns on in vivo antidiuretic response to desmopressin acetate administered transdermally.
The effects of concentration, amperage and duration on the antidiuretic response induced by iontophoretic delivery of desmopressin acetate (DDAVP) were examined using a diabetes insipidus model in rats. A higher current density brought about a larger and longer antidiuretic response. Prolonged iontophoretic duration caused an overdose. Repeated short iontophoretic treatments with lower current density maintained a constant response with a short lag time and a rapid disappearance of pharmacological response immediately after cessation of the final treatment. This type of iontophoresis substantially reduced the inter-subject variability of response as compared to the response using an intranasal route of administration.
Nakakura
M
M
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Terajima
M
M
Kato
Y
Y
Hayakawa
E
E
Ito
K
K
Kuroda
T
T
D000279:Administration, Cutaneous; D000281:Administration, Intranasal; D000818:Animals; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D062787:Drug Overdose; D007478:Iontophoresis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption
D003894:Deamino Arginine Vasopressin