title: [Vaccine against Haemophilus influenzae type b--antibody response and adverse effects].
abstract: In 1992 it was decided to implement vaccination against Haemophilus influenzae type b (Hib) in the Norwegian vaccination programme. The chosen vaccine consists of Hib-polysaccharide conjugated to tetanus toxoid. To suit the Norwegian vaccination schedule, Hib-vaccine was given together with vaccine against diphtheria, tetanus and pertussis (DTP) at three, five and ten months of age. Since all earlier studies with the Hib-vaccine have used other time schedules, a pilot study was conducted to test antibody response and side effects when using the Norwegian schedule. 44 infants were vaccinated with Hib-vaccine and DTP at three, five and ten months of age. Blood samples showed that 95% had protective antibody titer against Hib after two doses, 100% after three. The response to the other antigens was adequate. There were only minor side effects. After introduction of the Hib-vaccine the incidence of invasive Hib-infection in children below three years of age has decreased considerably.
authors.affiliation: Avdeling for vaksine, Statens Institutt for Folkehelse, Oslo.
authors.forename: H
authors.initials: H
authors.lastname: Nøkleby
authors.forename: S
authors.initials: S
authors.lastname: Sandbu
authors.forename: H
authors.initials: H
authors.lastname: Käyhty
authors.forename: R M
authors.initials: RM
authors.lastname: Olander
authors.forename: C
authors.initials: C
authors.lastname: Heilmann
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis*; D016667:Bacterial Capsules; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D006193:Haemophilus influenzae / Q000276:immunology; D006801:Humans; D007223:Infant; D009664:Norway; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial
vernacular_title: Vaksine mot Haemophilus influenzae type b--antistoffrespons og bivirkninger.