[Stimulation of platelet mitogen-induced prostaglandin I2 synthesis in periodontal tissue of cyclosporin A treated patients].
Cyclosporine A (CsA) is a highly potent immunosuppressive agent that has proven to be particularly useful in organ transplantation. Like phenytoin and the calcium antagonists, this drug may be associated with gingival hyperplasia. This study examined the interaction of platelet derived growth factor (PDGF) with prostaglandin I2 (PGI2)--a potent mediator in inflammation and bone resorption. PGI2 synthesis was examined by bioassay in gingival tissue from rats, rabbits and humans. Gingival tissue from CsA-treated patients generates less PGI2. PDGF causes a dose-dependent increase in PGI2 release in both CsA-treated and control subjects. The actual and percentage increase in PGI2 synthesis, however, was significantly higher in control tissue. While PDGF on the other hand modulated cellular proliferation, it causes on the other hand liberation of PGI2 from gingival tissue, thus interfering with its own action and further synthesis. If the PGI2 response is insufficient as after CsA therapy, the proliferative action might dominate. These findings therefore suggest an important pathogenetic role of PDGF and possibly other growth factors in CsA-induced gingival hyperplasia. "CsA gingivitis" seems to be a predominantly proliferative process, whereby inflammatory reactions appear only as a secondary phenomenon.
Nell
A
A
Abteilung für konservierende Zahnheilkunde, Universitätsklinik für Zahn-, Mund- und Kieferheilkunde, Wien.
Riegler
B
B
Ulm
C
C
Matejka
M
M
Sinzinger
H
H
D000328:Adult; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D046508:Culture Techniques; D016572:Cyclosporine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D005881:Gingiva / Q000187:drug effects* / Q000473:pathology; D005885:Gingival Hyperplasia / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010519:Periodontium / Q000187:drug effects* / Q000473:pathology; D015539:Platelet Activation / Q000187:drug effects*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D010982:Platelet-Derived Growth Factor; D016572:Cyclosporine; D011464:Epoprostenol
Stimulation der Plättchenmitogen-induzierten Prostaglandin I2-Synthese in periodontalem Gewebe von Cyclosporin A-behandelten Patienten.