title: The effect of Roux-en-Y diversion on gastric and Roux-limb emptying in a rodent model.
abstract: BACKGROUND
  The "Roux stasis syndrome" is characterized by symptoms of upper gut stasis following Roux-en-Y gastrojejunostomy (RG). Whether symptoms result from delayed gastric emptying, altered Roux-limb transit, or both has never been settled, partly because of the difficulty of measuring Roux-limb transit. The aim of this study was to develop a model to simultaneously quantitate Roux-limb transit and gastric emptying.
  
  
  METHODS
  Rats underwent vagotomy and antrectomy with RG or Billroth II reconstruction (B-II). Gastrointestinal transit of a solid meal (Technetium-99m sulfur colloid-labelled egg white) was assessed 0.5, 1, and 1.5 hours postprandial (pp). Transit of a liquid marker (Na51-CrO4 injected through an efferent-limb catheter) was measured at 25 minutes pp.
  
  
  RESULTS
  Solid gastric emptying was slower in RG than in B-II rats at 60 and 90 minutes pp. More of the solid meal and of the liquid marker was retained in the Roux limb than the efferent limb of the B-II at all time points (P < 0.05).
  
  
  CONCLUSIONS
  In a rodent model, Roux-en-Y gastrojejunostomy is associated with delayed gastric emptying and slowed efferent-limb transit of solids and liquids.
authors.affiliation: Department of Surgery, University of Florida College of Medicine, Gainesville, USA.
authors.forename: G
authors.initials: G
authors.lastname: Cheng
authors.forename: M P
authors.initials: MP
authors.lastname: Hocking
authors.forename: S B
authors.initials: SB
authors.lastname: Vogel
authors.forename: C A
authors.initials: CA
authors.lastname: Sninsky
mesh_terms: D000704:Analysis of Variance; D000713:Anastomosis, Roux-en-Y; D000818:Animals; D005746:Gastric Emptying / Q000502:physiology*; D005774:Gastrostomy / Q000379:methods*; D007582:Jejunostomy / Q000379:methods*; D007583:Jejunum / Q000601:surgery; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000601:surgery; D015996:Survival Rate