Nongenomic effects of 1,25-dihydroxyvitamin D3: potential relation of a plasmalemmal receptor to the acute enhancement of intestinal calcium transport in chick.
A number of model systems now exist for studying the nonnuclear actions of the seco-steroid hormone 1,25(OH)2D3. The perfused duodenal loop of vitamin D-replete chicks has provided the best correlation between nonnuclear actions and a physiological end point, namely enhanced calcium transport. Recent progress has been made in identifying and purifying an integral protein of the basal lateral membrane that may be a receptor for 1,25(OH)2D3. Studies with analogues (particularly 1,25(OH)2-7-dehydrocholesterol and 1,25(OH)2-lumisterol3) have provided definite correlations between binding to the solubilized membrane receptor and the ability to initiate transcaltachia (the rapid hormonal stimulation of calcium transport).
Nemere
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Department of Nutrition and Food Sciences, Utah State University, Logan 84322-8700, USA.
D000818:Animals; D001667:Binding, Competitive / Q000502:physiology; D001692:Biological Transport / Q000502:physiology; D002117:Calcitriol / Q000378:metabolism* / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000502:physiology; D002645:Chickens; D007413:Intestinal Mucosa / Q000378:metabolism*; D018167:Receptors, Calcitriol / Q000378:metabolism
D018167:Receptors, Calcitriol; D002117:Calcitriol; D002118:Calcium