Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms.
Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1 beta-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed.
Kumar
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S
Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia.
White
D L
DL
Takai
S
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Turczynowicz
S
S
Juttner
C A
CA
Hughes
T P
TP
D017209:Apoptosis / Q000235:genetics*; D001773:Blood Cells / Q000473:pathology; D053143:Caspase 2; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D003546:Cysteine Endopeptidases / Q000235:genetics*; D005809:Genes, Regulator / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007938:Leukemia / Q000209:etiology / Q000235:genetics; D008223:Lymphoma / Q000209:etiology / Q000235:genetics; D000090063:Proto-Oncogene Mas
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; C490360:CASP2 protein, human; D053143:Caspase 2; D003546:Cysteine Endopeptidases