title: Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in adult T-cell leukemia (ATL) in non-ATL-endemic Hokkaido of Japan.
abstract: Sera and peripheral blood lymphocytes of 40 adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido were examined for the prevalence of human T-cell leukemia virus type 1 (HTLV-I). All patients had HTLV-I-specific antibodies. When the peripheral lymphocytes were assessed after short-term cultivation, HTLV-I antigens and virus particles were detected. The seroprevalence in 96 cases of non-T-cell leukemias and lymphomas and in 30,056 healthy individuals in Hokkaido were 3.1% and 0.7%, respectively. HTLV-I seropositive inhabitants of Hokkaido can be estimated at about 40,000, and one out of every few thousand HTLV-I carriers is likely to develop ATL.
authors.affiliation: Department of Virology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iwanaga
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: S
authors.initials: S
authors.lastname: Fujiwara
authors.forename: O
authors.initials: O
authors.lastname: Oikawa
authors.forename: M
authors.initials: M
authors.lastname: Sugiura
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Osato
authors.forename: C
authors.initials: C
authors.lastname: Mikuni
authors.forename: I
authors.initials: I
authors.lastname: Maekawa
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
mesh_terms: D015481:HTLV-I Antibodies / Q000032:analysis; D015490:HTLV-I Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015458:Leukemia, T-Cell / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology / Q000821:virology; D015995:Prevalence
chemical_list: D015481:HTLV-I Antibodies