title: Chronic effects of azidothymidine and acyclovir on pregnant rats.
abstract: 1. The antiviral effect of azidothymidine (AZT) can be potentiated by acyclovir (ACV), and this drug association has been used in the management of HIV-infected patients. In the present study we examined the effects of such an association on rat pregnancy. 2. AZT (60 mg/kg b.w.) and ACV (60 mg/kg b.w.) were given to groups of pregnant rats once a day from the 1st to the 20th day of gestation. 3. Maternal body weight gain was severely affected by ACV; this effect was attenuated in rats treated with AZT+ACV and was virtually absent with AZT alone. 4. The abortive action of ACV was markedly diminished in the group treated with the association AZT+ACV. 5. The deleterious effects of ACV on rat pregnancy are presumably due to its extraplacental actions, and these are, at least in part, counteracted by concomitant treatment with AZT.
authors.affiliation: Department of Gynecology and Obstetrics, Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: J A
authors.initials: JA
authors.lastname: Mamede
authors.forename: M de J
authors.initials: Mde J
authors.lastname: Simões
authors.forename: N F
authors.initials: NF
authors.lastname: Novo
authors.forename: Y
authors.initials: Y
authors.lastname: Juliano
authors.forename: R M
authors.initials: RM
authors.lastname: Oliveira-Filho
authors.forename: L
authors.initials: L
authors.lastname: Kulay Júnior
mesh_terms: D000212:Acyclovir / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D015215:Zidovudine / Q000633:toxicity*
chemical_list: D015215:Zidovudine; D000212:Acyclovir