title: Prostate cancer screening: a decision analysis.
abstract: BACKGROUND
  The issue of whether to screen men for prostate cancer is controversial. No randomized clinical trials have been completed to confirm the efficacy of screening for prostate cancer. We created a mathematical model of the clinical risks and benefits of screening for prostate cancer.
  
  
  METHODS
  A Markov decision-analytic model evaluated the outcomes of annually screening asymptomatic men for prostate cancer beginning at age 50 years. The screening and testing algorithm included the digital rectal examination, transrectal ultrasound, and prostate-specific antigen test. A sample of 10 male patients with no history of prostate disease were interviewed to assess their utilities (preferences) regarding the various adverse outcomes of prostate cancer treatment.
  
  
  RESULTS
  The model indicated that no screening was preferred to screening when patients' utilities were considered (24.14 vs 23.47 quality-adjusted life years expected). The optimal decision was sensitive to the utilities of impotence and urethral stricture, the most common adverse outcomes for patients under the age of 65 years. When adverse outcomes of treatment were ignored, screening was favored (24.86 vs 24.22 years of life expectancy.
  
  
  CONCLUSIONS
  When quality-of-life preferences of men are considered, the annual screening of asymptomatic patients for prostate cancer is not recommended.
authors.affiliation: Department of Family Medicine, University of Texas Medical Branch at Galveston, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Cantor
authors.forename: S J
authors.initials: SJ
authors.lastname: Spann
authors.forename: R J
authors.initials: RJ
authors.lastname: Volk
authors.forename: M P
authors.initials: MP
authors.lastname: Cardenas
authors.forename: M M
authors.initials: MM
authors.lastname: Warren
mesh_terms: D000368:Aged; D003661:Decision Support Techniques; D007172:Erectile Dysfunction / Q000209:etiology; D006801:Humans; D008297:Male; D008390:Markov Chains; D008403:Mass Screening; D008875:Middle Aged; D011468:Prostatectomy / Q000009:adverse effects; D011471:Prostatic Neoplasms / Q000517:prevention & control* / Q000628:therapy; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects; D016896:Treatment Outcome; D014525:Urethral Stricture / Q000209:etiology