title: Mutants of dermatophytes resistant to ketoconazole.
abstract: Authors describe the frequency and properties of mutants resistant to ketoconazole, obtained from the dermatophytes Microsporum gypseum and Trichophyton mentagrophytes. Spontaneous mutants occurred with the frequency of 10(-9) to spore and nucleus. Ultraviolet radiation increased the frequency of mutants by two numeric orders. The resistance level was relatively small in both types of mutants (RL within the range of 2-5).
authors.affiliation: Institute of Biology, Medical faculty Olomouc, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Lenhart
authors.forename: A
authors.initials: A
authors.lastname: Merkunová
mesh_terms: D004352:Drug Resistance, Microbial; D007654:Ketoconazole / Q000494:pharmacology*; D008864:Microsporum / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D014249:Trichophyton / Q000187:drug effects* / Q000235:genetics
chemical_list: D007654:Ketoconazole