Regulated secretion. Helper proteins for neuroendocrine secretion.
The granins, known to be general constituents of neuroendocrine secretory granules, are regulators of the proteolytic processing of peptide precursors and promote their aggregation-mediated sorting into secretory granules.
Huttner
W B
WB
Department of Neurobiology, University of Heidelberg, Germany.
Natori
S
S
D000818:Animals; D002460:Cell Line; D002864:Chromogranins / Q000502:physiology*; D003594:Cytoplasmic Granules / Q000502:physiology* / Q000648:ultrastructure; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D008954:Models, Biological; D009490:Neurosecretory Systems / Q000502:physiology* / Q000648:ultrastructure*; D045706:Proprotein Convertase 2; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000502:physiology*; D013381:Subtilisins / Q000378:metabolism*
D002864:Chromogranins; D011506:Proteins; D010450:Endopeptidases; D013381:Subtilisins; D045706:Proprotein Convertase 2