title: Effects of simvastatin on liver and plasma levels of cholesterol, dolichol and ubiquinol in hypercholesterolemic rats.
abstract: Increased levels of blood cholesterol are considered as a major factor in the development of atherosclerosis. Simvastatin, a drug which blocks hydroxymethylglutaryl coenzyme A reductase (HMGCoAR), reduces plasma cholesterol and increases HDL-cholesterol in rats fed a hypercholesterolemic diet. Moreover, simvastatin produces a significant decrease of ubiquinol and dolichol in plasma and in liver.
authors.affiliation: Istituto di Patologia Generale, Università di Genova.
authors.forename: U M
authors.initials: UM
authors.lastname: Marinari
authors.forename: M A
authors.initials: MA
authors.lastname: Pronzato
authors.forename: D
authors.initials: D
authors.lastname: Dapino
authors.forename: P
authors.initials: P
authors.lastname: Gazzo
authors.forename: N
authors.initials: N
authors.lastname: Traverso
authors.forename: D
authors.initials: D
authors.lastname: Cottalasso
authors.forename: P
authors.initials: P
authors.lastname: Odetti
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D004286:Dolichols / Q000097:blood / Q000378:metabolism*; D006937:Hypercholesterolemia / Q000209:etiology / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D019821:Simvastatin; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism
chemical_list: D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004286:Dolichols; D014280:Triglycerides; D014451:Ubiquinone; D008315:Malondialdehyde; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin; C003741:ubiquinol