[Effects of intravenous anaesthetics on excitation, conduction, and refractory parameters of the heart. Experimental study in the dog].
Cardiac excitation, conduction, and refractory parameters of the heart were investigated in 59 beagle dogs to obtain basic values under the influence of the following 11 intravenous anaesthetic regimes using HIS-bundle electrography and programmed stimulation: 1. Alfentanil/midazolam/succinylcholine; 2. alfentanil/midazolam/succinylcholine/atropine; 3. fentanyl/midazolam/pancuronium bromide; 4. fentanyl-droperidol/chloralose/urethane; 5. ketamine/xylazine; 6. ketamine/xylazine/atropine; 7. propionylpromazine/pentobarbital; 8. propionylpromazine/levomethadon; 9. propofol; 10. propofol/alfentanil; 11. Tiletamine-zolazepam. It could be shown, that some intravenous anaesthetics under laboratory conditions have a strong influence on the observed cardiac parameters that must be considered in experiments with other substances or in cardiovascular results.
Hahn
N
N
Klinik und Poliklinik für Anästhesiologie und spezielle Intensivmedizin, Medizinische Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn.
Hörnchen
U
U
Eichelkraut
W
W
D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002036:Bundle of His / Q000187:drug effects; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D012032:Refractory Period, Electrophysiological / Q000187:drug effects*
D000777:Anesthetics
Wirkungen intravenöser Anästhetika auf Erregungsbildung, Reizleitung und Refraktäritätsparameter des Herzens. Experimentelle Untersuchungen am Hund.