Possible role of herpes simplex virus in the origin of Posner-Schlossman syndrome.
OBJECTIVE
We conducted this study to determine if the herpesviruses are possible etiologic agents in Posner-Schlossman syndrome. We aspirated aqueous humor samples from patients during acute attacks of the syndrome. Ten normal aqueous humor specimens from patients undergoing cataract surgery were used as controls. DNA was extracted and subjected to polymerase chain reaction amplification and Southern blot hybridization.


CONCLUSIONS
All three specimens were positive for amplified genomic fragments of herpes simplex virus and negative for varicella-zoster virus and cytomegalovirus. Ten normal aqueous specimens were negative for all three. Herpes simplex virus may play a role in the origin of Posner-Schlossman syndrome.
Yamamoto
S
S
Department of Virology, Schepens Eye Research Institute, Boston, MA 02114, USA.
Pavan-Langston
D
D
Tada
R
R
Yamamoto
R
R
Kinoshita
S
S
Nishida
K
K
Shimomura
Y
Y
Tano
Y
Y
D000208:Acute Disease; D000328:Adult; D001082:Aqueous Humor / Q000737:chemistry; D015139:Blotting, Southern; D003587:Cytomegalovirus / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000302:isolation & purification; D014645:Herpesvirus 3, Human / Q000235:genetics; D006801:Humans; D015863:Iridocyclitis / Q000209:etiology*; D016849:Keratitis, Herpetic / Q000150:complications* / Q000473:pathology; D009798:Ocular Hypertension / Q000209:etiology*; D016133:Polymerase Chain Reaction; D013577:Syndrome
D004279:DNA, Viral