title: Influence of intestinal inflammation (IBD) and small and large bowel length on fecal short-chain fatty acids and lactate.
abstract: Treatment with short-chain fatty acids (SCFAs) seems promising in ulcerative colitis and changes in colonocyte oxidation of butyrate have been suggested to be of importance for the development of this disease. The influence of small and large bowel length after surgery on SCFAs is only partly known. SCFAs and lactate were measured in consecutive fecal samples from 300 patients with ulcerative colitis (103), Crohn's disease (127), and noninflammatory bowel disease (70); 205 had had surgery, 52 had short bowels (< 200 cm). Lactate (mainly the L-isomer) was elevated in ulcerative colitis patients with pancolitis (mean +/- SEM, 17 +/- 5 mmol/liter) and proctitis (12 +/- 3 mmol/liter) compared with quiescent ulcerative colitis (3 +/- 1 mmol/liter, P < 0.01), and correlated with the index of Truelove (R = 0.52, P < 0.0005). Lactate was also increased in Crohn's colitis (21 +/- 8 mmol/liter), but not in isolated ileitis (4 +/- 2 mmol/liter), compared with quiescent Crohn's disease (7 +/- 2 mmol/liter, P < 0.02), but did not correlate with the activity index (CDAI; R = 0.18, P = 0.12). In contrast to earlier reports, SCFAs (including butyrate) did not correlate with inflammatory activity or localization in either ulcerative colitis or Crohn's disease. The length of the small bowel had no influence on SCFAs and lactate in patients with either no colonic function (ileostomies), or with > 50% and < 50% preserved colorectal length, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine A, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Hove
authors.forename: P B
authors.initials: PB
authors.lastname: Mortensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002648:Child; D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D005232:Fatty Acids, Volatile / Q000032:analysis*; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015212:Inflammatory Bowel Diseases / Q000378:metabolism* / Q000601:surgery; D007420:Intestine, Large / Q000378:metabolism* / Q000601:surgery; D007421:Intestine, Small / Q000378:metabolism* / Q000601:surgery; D007773:Lactates / Q000032:analysis*; D019344:Lactic Acid; D016014:Linear Models; D008297:Male; D008875:Middle Aged
chemical_list: D005232:Fatty Acids, Volatile; D007773:Lactates; D019344:Lactic Acid