Long-term survival and predictors of mortality in Alzheimer's disease and multi-infarct dementia.
Long-term survival was examined for 218 patients with Alzheimer's disease (AD) and 115 patients with multi-infarct dementia (MID). The 14-year survival rate for AD was 2.4% versus an expected rate of 16.6%, and for MID 1.7% versus 13.3% expected. MID showed a more malignant natural course than AD. Men carried a less favourable survival prognosis than women, both in AD and MID: the relative risk of dying for women was half that for men in both diseases. In MID, advanced disability indicated a relative risk of dying over twice as high. In both diseases the risk of death was substantially higher in the event of occurrence of primitive reflexes.
Mölsä
P K
PK
Department of Neurology, University of Turku, Finland.
Marttila
R J
RJ
Rinne
U K
UK
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000401:mortality*; D015161:Dementia, Multi-Infarct / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012737:Sex Factors; D012923:Social Class; D015996:Survival Rate