title: CT-guided pleural needle biopsy in the diagnosis of malignant mesothelioma.
abstract: OBJECTIVE
  Our goal was to determine the sensitivity of CT-guided closed pleural needle biopsy (CPNB) for the histopathologic diagnosis of diffuse malignant pleural mesothelioma (DMPM).
  
  
  METHODS
  Thirty patients with DMPM were studied with CT-guided CPNB. Tumor specimens were classified according to their cell types.
  
  
  RESULTS
  In 25 (83.3%) patients, the diagnosis was made by CT-guided CPNB. The remaining five patients were diagnosed by thoracoscopy, thoracotomy, or excisional biopsy of the chest wall mass. Pneumothorax was observed in 9.5% of patients and local seeding of tumor in 21.7% of patients who underwent CPNB.
  
  
  CONCLUSIONS
  Properly performed CPNB under CT guidance may yield an increased sensitivity for the diagnosis of diffuse malignant pleural mesothelioma.
authors.affiliation: Department of Chest Diseases, Osmangazi University Medical Faculty, Eskişehir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Metintaş
authors.forename: N
authors.initials: N
authors.lastname: Ozdemir
authors.forename: S
authors.initials: S
authors.lastname: Işiksoy
authors.forename: T
authors.initials: T
authors.lastname: Kaya
authors.forename: M
authors.initials: M
authors.lastname: Ekici
authors.forename: S
authors.initials: S
authors.lastname: Erginel
authors.forename: E
authors.initials: E
authors.lastname: Harmanci
authors.forename: P
authors.initials: P
authors.lastname: Erdinç
authors.forename: N
authors.initials: N
authors.lastname: Ulgey
authors.forename: F
authors.initials: F
authors.lastname: Alataş
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*