Geranylgeraniol is a potent inducer of apoptosis in tumor cells.
We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol) had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM.
Ohizumi
H
H
School of Pharmaceutical Sciences, Showa University, Tokyo.
Masuda
Y
Y
Nakajo
S
S
Sakai
I
I
Ohsawa
S
S
Nakaya
K
K
D000230:Adenocarcinoma / Q000473:pathology*; D017209:Apoptosis / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000473:pathology*; D004224:Diterpenes / Q000494:pharmacology*; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D014407:Tumor Cells, Cultured
D004224:Diterpenes; C017338:geranylgeraniol