[Overdosing on diltiazem in heptic insufficiency].
In a patient with hepatic failure of middle grade diltiazem at standard therapeutic dosis for unstable angina caused collateral fuss on atrioventricular conduction. This event is not considered in medical literature or on the schedule of the product. Because of the pharmacokinetics features of diltiazem, a higher risk of side effects can be expected if a abnormality of hepatic function is present.
Rossini
D
D
USL 20/A Regione Toscana, San Giovanni Valdarno (AR), U.O. Malattie Cardiovascolari.
Falsini
G
G
Palmerini
L
L
Grazzini
M
M
D000789:Angina, Unstable / Q000188:drug therapy*; D004110:Diltiazem / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D015716:Electrocardiography, Ambulatory; D006327:Heart Block / Q000139:chemically induced*; D006801:Humans; D017093:Liver Failure / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*
D004110:Diltiazem; D009543:Nifedipine
Sovradosaggio del diltiazem in presenza di insufficienza epatica.