Human metabolism of aluminium-26 and gallium-67 injected as citrates.
1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left the blood after 15 min and the decline continued, leaving < 1% in blood after 2 d; the losses occurred both to renal excretion and through uptake by other compartments. Estimated excretion up to 13 d was 83% (urine) and 1.8% (faeces). Whole-body retention of 15% at 13 d declined to approximately 4% at 1178 d, when the daily reduction corresponded to a biological half-life of 7 y, suggesting that sustained intake of dietary aluminium may lead to a progressively increasing internal deposit. 3. The metabolism of 67Ga differed markedly from that of 26Al in all aspects studied.
Priest
N D
ND
Biomedical Research Department, AEA Technology, Didcot, Oxon, UK.
Newton
D
D
Day
J P
JP
Talbot
R J
RJ
Warner
A J
AJ
D000328:Adult; D000535:Aluminum / Q000008:administration & dosage / Q000378:metabolism*; D002951:Citrates / Q000008:administration & dosage / Q000378:metabolism*; D005710:Gallium Radioisotopes / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013051:Spectrometry, Gamma
D002951:Citrates; D005710:Gallium Radioisotopes; D000535:Aluminum