Human leucocyte antigen phenotypes and gold-induced remissions in patients with rheumatoid arthritis.
To assess possible associations between human leucocyte antigens (HLA) and the achievement of remission during gold treatment, HLA typing was performed in 67 rheumatoid arthritis (RA) patients with a gold-induced remission and in 25 control RA patients who discontinued gold therapy because of lack of efficacy. Both groups of RA patients showed a significantly higher frequency of DR4 antigen and lower frequency of DR6 than a control population. There were no significant differences in HLA antigens between remission-responders and non-responders. It is concluded that HLA typing is not helpful in predicting the therapeutic response to parenteral gold therapy.
ten Wolde
S
S
Department of Rheumatology, University Hospital Leiden, The Netherlands.
Dijkmans
B A
BA
van Rood
J J
JJ
Claas
F H
FH
De Vries
R R
RR
Hazes
J M
JM
van Riel
P L
PL
van Gestel
A
A
Breedveld
F C
FC
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology*; D005260:Female; D006046:Gold / Q000627:therapeutic use*; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000032:analysis; D015808:HLA-DR6 Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012074:Remission Induction
D006680:HLA Antigens; D015804:HLA-DR4 Antigen; D015808:HLA-DR6 Antigen; D006046:Gold