Random X chromosome inactivation in a female with a variant of Wiskott-Aldrich syndrome.
A 15-month-old female presented with eczema, thrombocytopenia, recurrent infections and failure to thrive. She had low serum IgM and IgG subclasses and an abnormal lymphocyte proliferative response to periodate in vitro. Molecular X chromosome inactivation analysis, using the polymorphic HUMARA DNA probe, showed that the infant has random X chromosome inactivation. We conclude that she has an atypical form of Wiskott-Aldrich syndrome which may be inherited in an autosomal recessive manner.
Russell
S J
SJ
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063, USA.
Nisen
P D
PD
D002455:Cell Division / Q000276:immunology; D004303:Dosage Compensation, Genetic; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008214:Lymphocytes / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000235:genetics* / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M