Validation of a computer model of haemorrhage and transcapillary refill.
A computer model is described which uses blood volume deficit and its duration to simulate the first two hours of haemorrhage, including an estimation of the blood volume added by Starlings transcapillary refill mechanism. Computer prediction of the haematocrit was compared with published data on haemorrhage in animals. There was close correlation with data on the haemodilution caused by Starling's transcapillary refill mechanism in conscious swine (r = 0.84).
Mardel
S N
SN
Accident and Emergency Department, Aberdeen Royal Infirmary, UK.
Simpson
S H
SH
Kelly
S
S
Wytch
R
R
Beattie
T F
TF
Menezes
G
G
D000818:Animals; D001810:Blood Volume / Q000502:physiology; D002196:Capillaries / Q000503:physiopathology; D003198:Computer Simulation; D004285:Dogs; D006400:Hematocrit; D006438:Hemodilution; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D051381:Rats; D012756:Sheep; D013552:Swine