Effects of inflammatory irritant application to the rat temporomandibular joint on jaw and neck muscle activity.
An electromyographic (EMG) study was carried out in 40 anaesthetized rats to determine if the activity of jaw and neck muscles could be influenced by injection of the small-fibre excitant and inflammatory irritant mustard oil into the region of the temporomandibular joint (TMJ). Injection of a vehicle (mineral oil, 20 microliters) did not produce any significant change in EMG activity. In contrast, injection of mustard oil (20 microliters, 20%) evoked increases in EMG activity in the jaw muscles but not in the neck muscles. The increased EMG activity evoked by mustard oil was reflected in 1 or 2 phases of increased activity. The early EMG increase occurred soon after the mustard oil injection (mean latency +/- SD: 3.5 +/- 2.3 sec), peaked within 1 min, and then subsided (mean duration: 7.5 +/- 5.2 min). The later EMG increase occurred at 14.6 +/- 10.0 min after the mustard oil injection and lasted 14.3 +/- 12.3 min. These excitatory effects of mustard oil on the EMG activity of jaw muscles appear to have a reflex basis since they could be abolished by pre-administration of local anaesthetic into the TMJ region. These results document that TMJ injection of mustard oil results in a sustained and reversible activation of jaw muscles that may be related to the reported clinical occurrence of increased muscle activity associated with trauma to the TMJ.
Yu
X-M
XM
Faculty of Dentistry, University of Toronto, Toronto, Ont. M5G 1G6 Canada Canadian Memorial Chiropractic College, Toronto, Ont. M4G 3E6 Canada.
Sessle
B J
BJ
Vernon
H
H
Hu
J W
JW
D000818:Animals; D004576:Electromyography; D005260:Female; D007249:Inflammation / Q000139:chemically induced; D007267:Injections; D007509:Irritants / Q000494:pharmacology*; D007568:Jaw; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects; D009149:Mustard Plant; D009334:Neck Muscles / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013705:Temporomandibular Joint Disorders / Q000139:chemically induced*
D007509:Irritants; D010936:Plant Extracts; D010938:Plant Oils; D008012:Lidocaine; C027793:mustard oil