[The possible glyciram stimulation of bone marrow hematopoiesis under cytostatic blood depression].
The present study was undertaken to examine whether glycyrram orally given can correct blood abnormalities caused by a single maximal tolerable dose of fluorouracil. Glycyrram was demonstrated to stimulate the recovery of granulocytic and erythroid populations of bone marrow hemopoiesis. The stimulating effect of glycyrram was associated with its activating action on the function of hemopoietic microenvironmental cells.
Dygaĭ
A M
AM
Zhdanov
V V
VV
Khlusov
I A
IA
Liubavina
P A
PA
Novitskiĭ
E V
EV
Kusmartsev
S A
SA
Gol'dberg
E D
ED
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002452:Cell Count / Q000187:drug effects; D003114:Colony-Forming Units Assay; D003864:Depression, Chemical; D005472:Fluorouracil / Q000494:pharmacology*; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D013268:Stimulation, Chemical; D013997:Time Factors
D006034:Glycyrrhetinic Acid; D005472:Fluorouracil
O vozmozhnosti stimuliatsii glitsiramom kostnomozgovogo krovetvoreniia v usloviiakh tsitostaticheskoĭ gemodepressii.