Different tracers and stressors in patients with coronary artery disease: how to standardize clinical questions and nuclear cardiology answers.
The recent introduction of new tracers and stressors has increased the number of combinations of techniques that can be used for the diagnostic and prognostic stratification of patients with coronary artery disease. However, these new techniques still need to be standardized for clinical use. Thallium-201 scintigraphy is at present the most common method to assess transient ischemia and viability in patients. Dynamic exercise and dipyridamole show similar incidence of major cardiac complications and their use can be considered sufficiently safe. Further experimental and multicenter clinical studies are needed for 99mTc-Sestamibi and 99mTc-Teboroxime and for new stressors such as adenosine and dobutamine.
Marzullo
P
P
CNR Institute of Clinical Physiology, Pisa, Italy.
Sambuceti
G
G
Gimelli
A
A
Giorgetti
A
A
Parodi
O
O
D000241:Adenosine; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004176:Dipyridamole; D004280:Dobutamine; D005080:Exercise Test; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes
D015609:Organotechnetium Compounds; D010091:Oximes; D013794:Thallium Radioisotopes; D004280:Dobutamine; D004176:Dipyridamole; D017256:Technetium Tc 99m Sestamibi; D000241:Adenosine; C060156:technetium Tc 99m teboroxime