Efficacy and safety of live recombinant BCG vaccines.
BCG has a long history of safe use in humans and is one of the best adjuvants known. The use of newer production methods may further reduce the risk of adverse side-effects. Early results with experimental animals have shown BCG to be an effective live recombinant delivery vehicle for several foreign vaccine antigens. Additional refinements to the safety and efficacy of the recombinant BCG vaccine vehicle are under development.
Hanson
M S
MS
Medimmune, Inc., Gaithersburg, MD, USA.
Bansal
G P
GP
Langermann
S
S
Stover
C K
CK
Orme
I
I
D000818:Animals; D001500:BCG Vaccine / Q000009:adverse effects* / Q000235:genetics / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005822:Genetic Vectors; D006801:Humans; D007114:Immunization; D007613:Kanamycin Resistance / Q000235:genetics; D009163:Mycobacterium bovis / Q000235:genetics / Q000276:immunology; D011995:Recombination, Genetic; D012449:Safety; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000235:genetics / Q000494:pharmacology
D001500:BCG Vaccine; D014614:Vaccines, Synthetic