title: The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein.
abstract: An unusually small (8 kD) protein (p8MTCP-1) is coded by the putative oncogene MTCP-1 (also called c6.1B), involved in the translocation t(X;14)(q28;q11) associated with some mature T-cell proliferations. Here, we show by subcellular fractionation and by confocal microscopy that this protein is located in the mitochondria. This localization orientates toward a role of p8MTCP-1 in the mitochondrial metabolism which may be relevant for the oncogenic process.
authors.affiliation: Laboratoire d'Hématologie Moléculaire, Hôpital Saint Louis, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Madani
authors.forename: J
authors.initials: J
authors.lastname: Soulier
authors.forename: M
authors.initials: M
authors.lastname: Schmid
authors.forename: R
authors.initials: R
authors.lastname: Plichtova
authors.forename: F
authors.initials: F
authors.lastname: Lermé
authors.forename: O
authors.initials: O
authors.lastname: Gateau-Roesch
authors.forename: J P
authors.initials: JP
authors.lastname: Garnier
authors.forename: M
authors.initials: M
authors.lastname: Pla
authors.forename: F
authors.initials: F
authors.lastname: Sigaux
authors.forename: M H
authors.initials: MH
authors.lastname: Stern
mesh_terms: D000595:Amino Acid Sequence; D005455:Fluorescent Antibody Technique; D006801:Humans; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000378:metabolism*; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: C082870:MTCP1 protein, human; D011518:Proto-Oncogene Proteins