title: [Consecutive annual changes in minimum inhibitory concentration in clinically isolated Neisseria gonorrhoeae strains].
abstract: Between 1983 and 1991, 465 gonococcal strains isolated in the urological department of Japanese Red Cross Medical Center. The minimum inhibitory concentration (MIC) of these isolates to 22 kinds of antibiotics including penicillins (PC), cephems, tetracyclins (TC) and new quinolons (NQ) were determined and the annual difference of MIC was studied. The annual incidence of penicillinase producing neisseria gonorrhoeae (PPNG) of these 9 years were distributed in 3 to 17% and increasing tendency was not observed. As for Penicillin G, the MIC 90 of PPNG was seven fold higher than that of non-PPNG. No remarked difference was observed between MIC 90 of Cephems, TC and NQ of PPNG and non-PPNG. No annual difference was observed in MIC of PC, Cephems and SPCM. However the rising tendency of MIC was observed in NQ.
authors.affiliation: Department of Urology, Japanese Red Cross Medical Center.
authors.forename: K
authors.initials: K
authors.lastname: Takai
authors.forename: Y
authors.initials: Y
authors.lastname: Koyama
authors.forename: H
authors.initials: H
authors.lastname: Kojima
authors.forename: M
authors.initials: M
authors.lastname: Oshi
authors.forename: K
authors.initials: K
authors.lastname: Kawabe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002584:Cervix Uteri / Q000382:microbiology; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D010403:Penicillin Resistance; D013753:Tetracycline Resistance; D014521:Urethra / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents