HIV retrotransposon activity and the immunopathogenesis of AIDS.
This article presents the new hypothesis that HIV retrotransposon insertional mutagenesis induces genomic effects that bring about immune dysfunction through disruption, deletion or rearrangement of the genome of the host. This activity may be augmented by the action of most, if not all, the cofactors of HIV-induced disease.
Johnson
E J
EJ
Dept of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112-2699, USA.
Sizemore
R C
RC
Gottlieb
A A
AA
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000235:genetics / Q000276:immunology* / Q000821:virology; D015894:Genome, Human; D006678:HIV / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D016254:Mutagenesis, Insertional / Q000235:genetics*; D018626:Retroelements / Q000235:genetics*
D018626:Retroelements