[Radiation-induced neuropathies. Experimental and clinical data].
In contrast with the central nervous system, the peripheral nerves are usually considered radioresistant. However, experimental and clinical data show evidence of peripheral nerve injury after radiation therapy. The physiopathology remains unclear. Vascular alterations appear to play an important role. Direct damage to axon or Schwann cell and nervous compression in areas of radiation fibrosis could also be involved. Clinically, brachial plexopathy is a well-recognized complication but all the structures of the peripheral nervous system can be involved: cranial nerves, roots, plexus and nerve trunks. A syndrome of early and reversible plexopathy differs from the classical progressive form with pejorative outcome. Radiation-induced peripheral nerve tumors are infrequent.
Pradat
P F
PF
Service de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Poisson
M
M
Delattre
J Y
JY
D000818:Animals; D001917:Brachial Plexus; D003389:Cranial Nerve Diseases / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D009381:Neoplasms, Radiation-Induced; D009437:Neuralgia / Q000209:etiology; D010243:Paralysis / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology; D011843:Radiculopathy / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors
Neuropathies radiques. Données expérimentales et cliniques.