title: Cu(II) binding by angiotensin II fragments: Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His. Competition between amino group and imidazole nitrogens in anchoring of metal ions.
abstract: Potentiometric and spectroscopic (absorption, circular dichroism and electron paramagnetic resonance) study on the coordination of two angiotensin II fragments (Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His) to Cu(II) ions has shown that competition between amino and imidazole nitrogens to anchor metal ions is a complicated process and may lead to formation of macrochelate rings. The important factor that influences this competition is the distance between competing His and N-terminal residues (number of spacer residues in a peptide sequence).
authors.affiliation: Institute of Chemistry, University of Wroclaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Bal
authors.forename: M
authors.initials: M
authors.lastname: Jezowska-Bojczuk
authors.forename: H
authors.initials: H
authors.lastname: Kozlowski
authors.forename: L
authors.initials: L
authors.lastname: Chruscinski
authors.forename: G
authors.initials: G
authors.lastname: Kupryszewski
authors.forename: B
authors.initials: B
authors.lastname: Witczuk
mesh_terms: D000595:Amino Acid Sequence; D000804:Angiotensin II / Q000737:chemistry / Q000378:metabolism*; D001667:Binding, Competitive; D002412:Cations / Q000378:metabolism; D002942:Circular Dichroism; D003300:Copper / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007093:Imidazoles / Q000378:metabolism; D008969:Molecular Sequence Data; D009584:Nitrogen / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism*; D013053:Spectrophotometry
chemical_list: D002412:Cations; D007093:Imidazoles; D010446:Peptide Fragments; D000804:Angiotensin II; D003300:Copper; C029899:imidazole; D009584:Nitrogen