[The functional morphology of the spleen and lymphoid apparatus of the intestines in stress].
Structural and functional changes in the spleen and in the Payer plaques of the intestine under stress have been studied in 46 male rats. Stress activation of the adrenal cortex was blocked by metapiron injections. In cases of chronic stress along with the evident structural and functional damages in the immune system, in the spleen and in the peripheral blood there was a suppression of proliferative activity of T- and B-lymphocytes and an increase of functional activity of immuno-regulatory cells (T-suppressors). In chronic stress, specific compensatory changes due to the protective effect of metapiron preventing immunodepressive action of the adrenal gland hyperactivity were noted as well.
Zhuravleva
T B
TB
Iagmurov
O D
OD
Ogurtsov
R P
RP
D000302:Adrenal Cortex / Q000187:drug effects; D000818:Animals; D002908:Chronic Disease; D003864:Depression, Chemical; D007422:Intestines / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D008221:Lymphoid Tissue / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D013312:Stress, Physiological / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D013550:Swimming; D013997:Time Factors
D011725:Pyridines; C013109:metapyrone
Funktsional'naia morfologiia selezenki i limfoidnogo apparata kishechnika pri stresse.