title: Topical immunoglobulin is an effective therapy for parainfluenza type 3 in a cotton rat model.
abstract: A cotton rat model was used to test the efficacy of topical immunotherapy against parainfluenza type 3 (PIV3) infection. On day 3 after experimental infection with 10(5.5) pfu of PIV3, animals were treated with 2-fold dilutions of convalescent cotton rat serum or with one of two purified human immunoglobulin preparations; all three had moderate titers of anti-PIV3 neutralizing antibody (range, 1:200-1:1000). Therapy with high concentrations of all three preparations resulted in significant reductions of > or = 2 logs (> or = 100-fold) of pulmonary virus titers compared with titers for control animals. Little or no reduction in virus titers were seen in nasal tissues.
authors.affiliation: Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Ottolini
authors.forename: V G
authors.initials: VG
authors.lastname: Hemming
authors.forename: F M
authors.initials: FM
authors.lastname: Piazza
authors.forename: S A
authors.initials: SA
authors.lastname: Johnson
authors.forename: M E
authors.initials: ME
authors.lastname: Darnell
authors.forename: G A
authors.initials: GA
authors.lastname: Prince
mesh_terms: D000287:Administration, Topical; D000818:Animals; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000627:therapeutic use; D008168:Lung / Q000821:virology; D009297:Nasal Mucosa / Q000821:virology; D010224:Parainfluenza Virus 3, Human / Q000302:isolation & purification; D018184:Paramyxoviridae Infections / Q000276:immunology / Q000628:therapy*; D016205:Sigmodontinae
chemical_list: D007136:Immunoglobulins