Effect of bile obstruction on liver regeneration following major hepatectomy: an experimental study in the rat.
The regeneration of the liver following resection is regulated by a variety of factors and it might be expected that jaundice influences the process. We therefore evaluated the regenerative response to major hepatectomy in bile-obstructed rats. Two weeks after ligation of the common bile duct, a standardized 77% hepatectomy was undertaken. The jaundiced animals showed an augmented liver regeneration compared to nonjaundiced individuals (p < 0.01). However, blood clearance of radiolabelled Escherichia coli bacteria was impaired (p < 0.01) in animals with bile obstruction at 7 days after the hepatectomy, accompanied by reduced bacterial uptake in the liver as a sign of impaired reticuloendothelial system function.
Foss
A
A
Department of Surgery, National Hospital, Oslo University, Norway.
Andersson
R
R
Ding
J W
JW
Hochbergs
P
P
Paulsen
J E
JE
Bengmark
S
S
Ahrén
B
B
D000818:Animals; D002779:Cholestasis / Q000503:physiopathology*; D006498:Hepatectomy; D008115:Liver Regeneration; D008297:Male; D012157:Mononuclear Phagocyte System / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley