Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9: assignment of the human H2A.X gene to 11q23 by sequence analysis.
The H2A.X gene was cloned from the C3H mouse strain, and its structure was determined. Sequence analysis revealed that this gene is situated in close proximity to the porphobilinogen deaminase (PBGD) gene in the opposite orientation. The synteny is conserved in human. This permits us to assign the H2A.X gene to chromosome 9 and 11q23 in mouse and human, respectively.
Porcher
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C
INSERM U409, Faculté de Médecine Xavier Bichat, Université Paris 7, France.
Grandchamp
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B
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D017931:DNA Primers; D008040:Genetic Linkage; D006657:Histones / Q000235:genetics*; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000235:genetics; D004915:Leukemia, Erythroblastic, Acute; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured
D017931:DNA Primers; D006657:Histones; D012333:RNA, Messenger; D011163:Hydroxymethylbilane Synthase