Phenotypic modulation of gonococcal lipooligosaccharide in acidic and alkaline culture.
Neisseria gonorrhoeae infects a diverse array of niches in its human host, which expose the organism to dramatic variations in pH. We examined growth and lipooligosaccharide expression of two gonococcal strains in liquid and solid cultures under acidic, neutral, and alkaline conditions. Growth rates in broth were similar under the three conditions, and the pH remained fairly constant throughout the growth cycle. Altered lipooligosaccharide expression at the different pHs was noted in both plate- and broth-grown organisms.
Pettit
R K
RK
Department of Biology, State University of New York College at Potsdam 13676, USA.
Martin
E S
ES
Wagner
S M
SM
Bertolino
V J
VJ
D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008070:Lipopolysaccharides / Q000737:chemistry*; D009344:Neisseria gonorrhoeae / Q000737:chemistry* / Q000502:physiology
D001426:Bacterial Proteins; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides