[Effects of tetrandrine on cardiac hemodynamics of hypertrophied left ventricle from deoxycorticosterone-salt hypertensive rats].
Effects of tetrandrine (Tet) on cardiac mass and hemodynamic parameters were studied in deoxycorticosterone-salt (DOCA-salt) hypertensive rats. Treatment with Tet (50 mg.kg-1, qd x 9 wk) markedly lowered systolic blood pressure and left ventricular (LV) weight. Study on isolated working heart demonstrated that the Tet group compared with the LVH group, AP, LVSP, +/- dp/dtmax, LVDP, coronary blood flow and cardiac output were increased while LVEDP and T were decreased. Studies on LV pressure-volume relation showed that Tet can markedly improve the LV compliance and the LV stiffness constant of LVH rat. These findings suggest that the regression of LVH in DOCA-salt hypertensive rats with Tet is associated with improvement of the contraction, relaxation and pump function, especially relaxation function and hemodynamics.
Xu
Y
Y
Department of Cardiovascular Pharmacology, Nanjing Medical University.
Rao
M R
MR
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D044182:Benzylisoquinolines; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D016277:Ventricular Function, Left / Q000187:drug effects*
D000470:Alkaloids; D000959:Antihypertensive Agents; D044182:Benzylisoquinolines; C009438:tetrandrine; D003900:Desoxycorticosterone