Decrease of thyroid hormones in patients with familial hypercholesterolemia during dextran sulphate low-density lipoprotein apheresis.
Removal of low-density lipoproteins from plasma by dextran sulfate adsorption (DSA) in FH patients entails a decrease in plasma levels of thyroid hormones (-28.5% and -18.7%, respectively, for T3 and T4). This suggests that FH patients have a greater than normal fraction of thyroid hormones bound to lipoproteins, due to their expanded lipoprotein pool.
Pintus
S
S
Dismetabolic Diseases Centre, St. Michele Hospital, Cagliari, Italy.
Pintus
P
P
Piras
C
C
Loviselli
A
A
Muntoni
S
S
D000293:Adolescent; D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D016264:Dextran Sulfate; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D013963:Thyroid Hormones / Q000097:blood*
D008077:Lipoproteins, LDL; D013963:Thyroid Hormones; D016264:Dextran Sulfate