title: Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy.
abstract: We have investigated the influence of the functional insertion (I) and deletion (D) polymorphism in intron 16 of the gene for angiotensin-converting enzyme (ACE) in a retrospective study of 100 patients with IgA nephropathy. There was no difference in genotype frequency compared with normal subjects. However, patients homozygous for the D allele tended to present at an earlier age (medians: DD, 33; ID, 34; II, 42 years) and to require renal replacement therapy at a younger age (medians 37, 42, and 48 years, respectively). The rate of progression was significantly worse in patients homozygous for the D allele. The DD genotype is associated with increased severity of disease in patients with IgA nephropathy.
authors.affiliation: Renal Unit, Western Infirmary, Glasgow, UK.
authors.forename: P N
authors.initials: PN
authors.lastname: Harden
authors.forename: C
authors.initials: C
authors.lastname: Geddes
authors.forename: P A
authors.initials: PA
authors.lastname: Rowe
authors.forename: J H
authors.initials: JH
authors.lastname: McIlroy
authors.forename: M
authors.initials: M
authors.lastname: Boulton-Jones
authors.forename: R S
authors.initials: RS
authors.lastname: Rodger
authors.forename: B J
authors.initials: BJ
authors.lastname: Junor
authors.forename: J D
authors.initials: JD
authors.lastname: Briggs
authors.forename: J M
authors.initials: JM
authors.lastname: Connell
authors.forename: A G
authors.initials: AG
authors.lastname: Jardine
mesh_terms: D000328:Adult; D000483:Alleles; D001483:Base Sequence; D001794:Blood Pressure / Q000502:physiology; D003404:Creatinine / Q000097:blood; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007438:Introns; D008875:Middle Aged; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies
chemical_list: D017931:DNA Primers; D004247:DNA; D003404:Creatinine; D007703:Peptidyl-Dipeptidase A