[Local preventive antibacterial therapy with polymer biocompatible combination].
The paper provides data on the properties of the powdery antimicrobial absorbent Ambipor and the procedure of its use in the prevention of postoperative suppuration, which consists in application of the powder to the wound surface with a broken layer just before wound suture. It shows that a single application of Ambipor to wound suture. It shows that a single application of Ambipor to wound tissues at the end of an operation ensures high paravulnar tissue antibiotic concentrations which are many times higher those used in conventional antibacterial therapy. Implantation of Ambipor to operative wound tissue at the end of an operation aids to reduce the extent microbial dissemination by more than 100-1000 times, to accelerate reparative processes, stimulate early fibroplast activation, fibrillogenesis, scarring tissue maturation. Topical antibacterial therapy with the developed formulations is an effective tool in preventing postoperative wound complications. Its application to clinical practice enables the incidence of complications to be decreased by more than 4.5 times higher than those in the controls.
Volenko
A V
AV
Belykh
S I
SI
Firsova
E V
EV
Kravchuk
Zh N
ZhN
D000287:Administration, Topical; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D011108:Polymers / Q000494:pharmacology / Q000627:therapeutic use*; D011109:Polymethacrylic Acids / Q000627:therapeutic use*; D011205:Povidone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000503:physiopathology; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D001672:Biocompatible Materials; D011108:Polymers; D011109:Polymethacrylic Acids; C054377:butyl methacrylate-vinylpyrrolidone copolymer; D011205:Povidone
Polimernaia biosovmestimaia kombinatsiia dlia mestnoĭ profilakticheskoĭ antibakterialńoĭ terapii.