title: Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia.
abstract: We examined IL-6 levels in the cerebrospinal fluid (CSF) of patients clinically diagnosed with Alzheimer-type dementia (ATD) and with vascular dementia (VD) and of age-matched normal subjects. The IL-6 levels in the CSF of ATD, but not VD patients, were significantly decreased. In the early onset ATD patients (disease onset < 65 years), IL-6 levels were reduced to 21% of the control level. The IL-6 levels in the CSF were not associated with the severity of the dementia or the duration of the disease since the identification of the first symptoms.
authors.affiliation: Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Kono
authors.forename: H
authors.initials: H
authors.lastname: Umegaki
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: A
authors.initials: A
authors.lastname: Iguchi
authors.forename: T
authors.initials: T
authors.lastname: Fukatsu
authors.forename: N
authors.initials: N
authors.lastname: Nakashima
authors.forename: H
authors.initials: H
authors.lastname: Nishiwaki
authors.forename: Y
authors.initials: Y
authors.lastname: Shimada
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
mesh_terms: D000210:Acute-Phase Reaction / Q000134:cerebrospinal fluid; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged
chemical_list: D015850:Interleukin-6