Expression of an erythropoietin-like gene in the trout.
Cross-species Northern blot hybridization and radioimmunoassay have provided evidence for the expression of an erythropoietin (EPO)-like gene in the rainbow trout. The principal site of EPO-like mRNA and antigen expression in the adult trout appears to be the kidney which also acts as the major erythropoietic organ. The data suggest that a locally produced EPO-like factor may regulate renal erythropoiesis in bony fish and, furthermore, they identify a possible evolutionary origin for renal EPO production in mammals.
Shiels
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Department of Haematology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London.
Wickramasinghe
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D000818:Animals; D015152:Blotting, Northern; D004921:Erythropoietin / Q000096:biosynthesis / Q000235:genetics*; D015870:Gene Expression; D007668:Kidney / Q000378:metabolism; D017686:Oncorhynchus mykiss / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger; D004921:Erythropoietin