[Langerhans cell granulomatosis with unifocal bone disease and asymptomatic pulmonary infiltration].
Langerhans' cell granulomatosis is a usually benign disease, characterized by the proliferation of Langerhans' cell containing S-100 protein. Disease is related with the smoking habit and immunological alterations, and is able to affect any organ in isolated or multisystem form. Diagnosis is provided by biopsy of the lesion and bronchoalveolar lavage if the lung is injured. We present a case of a smoker man with lytic lesion in the skull, which biopsy was diagnostic, and with an asymptomatic interstitial infiltrates lungs, with a restrictive spirometry. Remission was achieved with prednisone (0.75 mg x kg) and stop smoking.
Martínez Albaladejo
M
M
Servicio de Medicina Interna, Hospital Comarcal del Noroeste, Caravaca de la Cruz, Murcia.
García López
B
B
de Paco Moya
M
M
Alguacil García
G
G
González Pina
B
B
Pérez Mila García
L
L
D000328:Adult; D001847:Bone Diseases / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D010014:Osteolysis / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012886:Skull / Q000473:pathology; D012907:Smoking / Q000009:adverse effects
D011241:Prednisone
Granulomatosis de células de Langerhans con afectación ósea unifocal e infiltrado pulmonar asintomático.