[Relationship between levels of aspartate aminotransferase in gingival crevicular fluid and periodontal disease activity].
This paper describes a longitudinal study in which clinical parameters and aspartate aminotransferase (AST) in gingival crevicular fluid (GCF) were monitored bimonthly over a 6-12 months period in 970 sites from 7 treated periodontitis patients. In this study, 21 out of 970 sites exhibited new attachment loss (AL) of at least 2mm between two consecutive visits. The GCF-AST levels and clinical parameters at sites with active tissue destruction (> or = 2mm AL within two months) were significantly higher than those at control sites on the same tooth. The GCF-AST levels and clinical parameters at sites with active tissue destruction decreased significantly after re-treatment. The measurement of GCF-AST could be an useful adjunctive criterion for detection of disease activity. However, it seems to be unsatisfactory in predicting disease activity.
Yan
F
F
School of Stomatology, Beijing Medical University.
Cao
C
C
Li
X
X
D001219:Aspartate Aminotransferases / Q000378:metabolism*; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D006801:Humans; D008137:Longitudinal Studies; D017622:Periodontal Attachment Loss / Q000201:enzymology; D010518:Periodontitis / Q000188:drug therapy / Q000201:enzymology*; D015572:Spiramycin / Q000627:therapeutic use
D015572:Spiramycin; D001219:Aspartate Aminotransferases