Effect of selenium supplementation on some blood biochemical parameters in male rats.
The long-term effect of selenium supplementation on blood glutathione peroxidase (GSH-Px) activity and plasma TBARS' production (as an index of peroxidation) was evaluated in 15-mo-old male rats fed a diet supplemented with 0.25 or 0.50 ppm selenium, for 12 mo. A group of nonsupplemented age-matched rats was the control. In addition, triglycerides, phospholipids, total and free cholesterol, HDL-cholesterol, and HDL-phospholipids levels were measured in plasma. Plasma testosterone levels were also determined in order to control the aging process in these animals. The GSH-Px activity and the peroxidation level were unchanged in all the groups. However, concerning the lipid parameters, a decrease in triglycerides concentration was observed in both treated groups (p < 0.05). Therefore, in these experimental conditions, despite no observed changes in parameters related to lipid peroxidation, selenium seems to be involved with triglycerides metabolism, eventually improving the triglycerides status of aged animals.
Crespo
A M
AM
Departamento de Zoologia e Antropologia, Faculdade de Ciências de Lisboa, Portugal.
Lança
M J
MJ
Vasconcelos
S
S
Andrade
V
V
Rodrigues
H
H
Santos
M C
MC
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004326:Drinking; D005979:Glutathione Peroxidase / Q000097:blood* / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D018038:Sodium Selenite / Q000008:administration & dosage; D013739:Testosterone / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D014867:Water
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008055:Lipids; D008075:Lipoproteins, HDL; D010743:Phospholipids; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D014867:Water; D013739:Testosterone; D002784:Cholesterol; D005979:Glutathione Peroxidase; D012643:Selenium; D018038:Sodium Selenite