[The effect of methyluracil polymorphism on lipid and antioxidant composition of rat tissues].
The effect of two methyluracil forms on the composition of lipids, the content of peroxidation products and the amount of lipid-soluble scavengers of free radicals was studied in rat liver and heart tissues. Both these forms caused an increase in content of total lipids in the animal liver tissue 2 hrs after injection, whereas beta-form increased 1.6-fold the content of cholesterol esters and 1.9-fold that of triglycerides in liver tissue, unlike the alpha-form which affected these parameters slightly. The effect of methyluracil polymorphic derivatives on lipid peroxidation (TBA-positive products) was not detected. The methyluracil beta-form, not affecting the total pool of hydrophobic antioxidants, was found to decrease the content of active scavengers of free radicals in rat liver and heart tissues, as well as beta-form decreased the content of vitamin E in these tissues. At the same time, the methyluracil alpha-form did not affect the composition of tissue hydrophobic antioxidants. These differences found in the effect of two methyluracil forms on lipid composition and lipid-soluble scavengers of free radicals may be responsible for biological nonequivalence of the drug polymorphic forms.
Leonidov
N B
NB
Romanenko
E B
EB
Lebedev
A V
AV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D016166:Free Radical Scavengers; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011110:Polymorphism, Genetic; D051381:Rats; D017208:Rats, Wistar; D014498:Uracil / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D000975:Antioxidants; D016166:Free Radical Scavengers; D014498:Uracil; C008378:6-methyluracil
Vliianie polimorfizma metiluratsila na sostav lipidov i antioksidantov v tkaniakh krys.