Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester.
The objective of this study was to assess the therapeutic advantage of glutathione ester along with cisplatin. Comparisons were made with renal reduced glutathione, enzymatic antioxidants, and lipid peroxidation levels. Cisplatin caused differential toxic effects on renal antioxidants and lipid peroxidation. However administration of glutathione ester modulates the toxic effects of cisplatin observed in renal antioxidants and lipid peroxidation. The finding that glutathione ester co-administration along with cisplatin is more effective and advantageous in protecting against the nephrotoxicity of cisplatin when it was given alone.
Babu
E
E
Department of Medical Biochemistry, University of Madras, India.
Gopalakrishnan
V K
VK
Sriganth
I N
IN
Gopalakrishnan
R
R
Sakthisekaran
D
D
D000818:Animals; D000975:Antioxidants; D001205:Ascorbic Acid / Q000494:pharmacology; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D005296:Ferrous Compounds / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005609:Free Radicals; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000032:analysis / Q000037:antagonists & inhibitors; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000032:analysis / Q000037:antagonists & inhibitors
D000975:Antioxidants; D005296:Ferrous Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D017382:Reactive Oxygen Species; C020748:ferrous sulfate; C058293:glutathione monoisopropyl ester; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid; D002945:Cisplatin