Correlation between serum pepsinogen concentration and gastric acidity measured by 24 h pH monitoring.
The relationship between the intragastric pH measured by 24 h pH monitoring system and the serum pepsinogen I/II ratio was studied in 68 cases. When pepsinogen I/II ratio was compared with pH 3.0 holding time (the percentage time during which the gastric pH is above 3.0), there was a negative correlation between these two parameters (correlation coefficient r = -0.62, P < 0.001). Furthermore, there was also a strong negative correlation between the early morning (from 03.00 to 06.00 h) gastric pH and pepsinogen I/II ratio (r = -0.76, P < 0.001). Accordingly, by simply measuring serum pepsinogen I and II, it may be possible to infer gastric acidity and to obtain the information concerning the early morning intragastric pH.
Kinoshita
Y
Y
Department of Internal Medicine, Kobe University School of Medicine, Japan.
Yamashita
Y
Y
Kitajima
N
N
Tojo
M
M
Itoh
T
T
Fukuzaki
H
H
Chiba
T
T
D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010435:Pepsinogens / Q000097:blood*
D010435:Pepsinogens