title: Effects of Nissen fundoplication on gastro-oesophageal reflux and oesophageal motor function.
abstract: BACKGROUND
  Nissen fundoplication reduces gastro-oesophageal reflux effectively, but the mechanisms through which this effect is brought about have remained rather obscure.
  
  
  METHODS
  In this study the effect of fundoplication on oesophageal acid exposure, oesophageal body motility, and lower oesophageal sphincter pressure (LOSP) was assessed prospectively. Eleven patients were studied before and 3 months after a floppy Nissen fundoplication. A Dent sleeve was used to measure LOSP, and ambulatory pH and pressure monitoring were used to evaluate oesophageal motor function.
  
  
  RESULTS
  Gastro-oesophageal reflux was significantly decreased after fundoplication without an increase in LOSP. The motor function of the oesophageal body was not affected by the antireflux procedure.
  
  
  CONCLUSIONS
  Nissen fundoplication is an effective antireflux operation, even though the procedure does not increase LOSP, and the motility pattern of the oesophageal body is not affected by the construction of a floppy fundic wrap.
authors.affiliation: Dept. of Gastroenterology, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Breumelhof
authors.forename: R
authors.initials: R
authors.lastname: Timmer
authors.forename: J H
authors.initials: JH
authors.lastname: Nadorp
authors.forename: A J
authors.initials: AJ
authors.lastname: Smout
mesh_terms: D000328:Adult; D004942:Esophagitis, Peptic / Q000503:physiopathology / Q000601:surgery*; D004943:Esophagogastric Junction / Q000503:physiopathology*; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008365:Manometry; D010528:Peristalsis / Q000502:physiology; D011312:Pressure