Acute interstitial nephritis associated with ticlopidine.
Ticlopidine, a platelet aggregation inhibitor, has been approved to decrease the risk of thrombotic stroke. We describe a 75-year-old white woman who developed acute renal failure 10 days after initiating ticlopidine therapy. A renal biopsy revealed interstitial infiltrates containing lymphocytes and eosinophils. To our knowledge this is the first report of ticlopidine-induced acute interstitial nephritis.
Rosen
H
H
Department of Medicine, Coney Island Hospital, Brooklyn, NY 11235, USA.
el-Hennawy
A S
AS
Greenberg
S
S
Chen
C K
CK
Nicastri
A D
AD
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000368:Aged; D001706:Biopsy; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D013988:Ticlopidine / Q000009:adverse effects* / Q000627:therapeutic use
D013988:Ticlopidine