Dopamine hypersensitivity in migraine: role in apomorphine syncope.
There is some evidence supporting a potential role of hypersensitivity of the dopaminergic system in the pathogenesis of migraine. In this case report, we describe a syncopal episode in a patient with migraine without aura after the administration of a very low dose of apomorphine, a classical agonist of dopaminergic receptors. The absence of cardiovascular risk factors in this patient suggests that the clinical event might have been caused by hypersensitivity of the dopaminergic system.
Del Zompo
M
M
Department of Neurosciences B.B. Brodie, Headache Center, University of Cagliari, Italy.
Lai
M
M
Loi
V
V
Pisano
M R
MR
D000328:Adult; D001058:Apomorphine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008881:Migraine Disorders / Q000503:physiopathology*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013575:Syncope / Q000209:etiology*
D011954:Receptors, Dopamine; D001058:Apomorphine