title: The specific inhibition of crystal growth of monohydrogen potassium L-tartrate by d-catechin.
abstract: Crystal growth of monohydrogen potassium L-tartrate in an ethanolic aqueous solution was specifically inhibited by d-catechin, but not by either its epimeric isomer at C3, l-epicatechin or by gallic acid and caffeic acid. 3D-Structure similarity search of d-catechin with two molecules of the tartrate and docking study of d-catechin with the crystal model of the tartrate suggested that d-catechin mimics a structure consisting of the two tartrate molecules in the inhibition. Differences in the conformation of the catechol moieties of d-catechin and l-epicatechin may explain the distinct inhibitory effects of the epimeric isomers.
authors.affiliation: Institute for Biomedical Research, Suntory Ltd, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Imajo
authors.forename: M
authors.initials: M
authors.lastname: Ishiguro
authors.forename: K
authors.initials: K
authors.lastname: Ishiguro
authors.forename: T
authors.initials: T
authors.lastname: Murashima
authors.forename: K
authors.initials: K
authors.lastname: Isoi
authors.forename: H
authors.initials: H
authors.lastname: Tanahashi
authors.forename: H
authors.initials: H
authors.lastname: Nishino
mesh_terms: D002392:Catechin / Q000737:chemistry*; D003196:Computer Graphics; D003460:Crystallization; D005419:Flavonoids; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012984:Software; D013644:Tartrates / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D013644:Tartrates; D002392:Catechin