Protective effect of chlorpromazine on TNF-mediated hapten-induced irritant reaction.
Picryl chloride-induced irritant reaction (IR) was shown to be mediated by tumor necrosis factor (TNF). Anti-TNF monoclonal antibodies, but not interleukin 1 receptor antagonist (IL-1 Ra), had a protective effect. Chlorpromazine (CPZ), an inhibitor of TNF synthesis, protected against IR and inhibited the IR-associated TNF induction in ear homogenates. Investigation of the role of polymorphonuclear leukocyte (PMN) in neutropenic mice showed that neutropenia did not prevent the development of the IR.
Erroi
A
A
Mario Negri Institute for Pharmacological Research, Milan, Italy.
Fantuzzi
G
G
Demitri
M T
MT
Echtenacher
B
B
Gnocchi
P
P
Isetta
A
A
Ghezzi
P
P
D000818:Animals; D000911:Antibodies, Monoclonal; D002746:Chlorpromazine / Q000494:pharmacology*; D017453:Dermatitis, Irritant / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D006241:Haptens / Q000502:physiology*; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D051379:Mice; D009503:Neutropenia / Q000139:chemically induced / Q000503:physiopathology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010853:Picryl Chloride / Q000633:toxicity; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D012795:Sialoglycoproteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000502:physiology*
D000911:Antibodies, Monoclonal; D006241:Haptens; C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha; D002746:Chlorpromazine; D010853:Picryl Chloride