[The immunogenetic status of patients with infectious endocarditis].
On the basis of a deep clinico-immunological examination of 23 patients with septic endocarditis it was established that HLA B35 antigen and haplotype A2-B35 are the most probable markers of the genetic predisposition to the development of infective endocarditis. Immune deficiency is accompanied by a decreased content of T-helpers, decreased activity of natural killers and phagocytic activity of granulocytes. A combination of a genetically determined defect of the immune response with a modification of histocompatibility antigens by infective agents, drugs (narcotics, antigens etc.) and other factors are thought to be of pathogenetic significance in the development of infective endocarditis.
Shevchenko
Iu L
IuL
Danil'chenko
V V
VV
Zhiburt
E B
EB
Serebrianaia
N B
NB
Khubulava
G G
GG
Katkova
I V
IV
D000293:Adolescent; D000328:Adult; D001021:Aortic Valve; D002648:Child; D004198:Disease Susceptibility; D004697:Endocarditis, Bacterial / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006349:Heart Valve Diseases / Q000235:genetics / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D014261:Tricuspid Valve
D006680:HLA Antigens
Immunogeneticheskiĭ status bol'nykh infektsionnym éndokarditom.