title: Frontal lobe dysfunction in schizophrenia and obsessive-compulsive disorder: a neuropsychological study.
abstract: Converging evidence suggests there is a specific role of dorso-lateral-prefrontal cortex (DLPC) in schizophrenic disorders and of orbito-frontal cortex (OFC) in obsessive-compulsive disorder (OCD). Here, 25 schizophrenic and 25 OCD patients were evaluated with Wisconsin Card Sorting Test and Object Alternation Test; neuropsychological tools sensitive to DLPC and OFC damage, respectively; and compared with 25 subjects of a control group. Moreover, they all underwent Weigl's Sorting Test and the Word Fluency Test to assess global frontal functioning. The results indicated a DLPC deficit in schizophrenia and an OFC involvement in OCD. These data suggest that functional disorders of the central nervous system can be explored with neuropsychological instruments.
authors.affiliation: Department of Biomedical and Technological Sciences, University of Milan Medical School, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Abbruzzese
authors.forename: L
authors.initials: L
authors.lastname: Bellodi
authors.forename: S
authors.initials: S
authors.lastname: Ferri
authors.forename: S
authors.initials: S
authors.lastname: Scarone
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D017397:Prefrontal Cortex / Q000503:physiopathology; D011594:Psychometrics; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology