Pancreatic disorders of pregnancy. Pregestational diabetes.
The outcome of pregnancies complicated by pregestational diabetes, both insulin-dependent and non-insulin-dependent, has changed dramatically since the discovery of insulin in the early 1920s. Now, patients with pregestational diabetes can safely undergo a pregnancy and be assured that the infant will be healthy. Unfortunately, a finite risk of problems still may occur, including congenital malformations, spontaneous abortions, and diabetic fetopathy classically manifest as a macrosomic infant. Treatment strategies, although tedious and sometimes onerous, do minimize these risks.
Healy
K
K
Sansum Medical Research Foundation, Santa Barbara, California, USA.
Jovanovic-Peterson
L
L
Peterson
C M
CM
D000022:Abortion, Spontaneous / Q000209:etiology; D000013:Congenital Abnormalities / Q000209:etiology*; D003928:Diabetic Nephropathies / Q000150:complications; D003930:Diabetic Retinopathy / Q000097:blood; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D010182:Pancreatic Diseases / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D012016:Reference Values; D012307:Risk Factors