Aberrant appearance of lung surfactant protein A in sera of patients with idiopathic pulmonary fibrosis and its clinical significance.
Pulmonary surfactant protein A (SP-A) is known to be a major phospholipid-associated glycoprotein in pulmonary surfactant, which is specific to the lung. In this study, the SP-A concentrations in sera of patients with various lung diseases were determined using an enzyme-linked immunosorbent assay. Patients with idiopathic pulmonary fibrosis (IPF) and pulmonary alveolar proteinosis (PAP) exhibited prominently high concentrations of serum SP-A compared to those of other lung diseases and healthy volunteers, although there were significant increases in serum SP-A concentrations in patients with pulmonary tuberculosis, chronic pulmonary emphysema, diffuse panbronchiolitis and bacterial pneumonia compared to those of healthy volunteers. Successive measurement in 2 patients with IPF showed that serum SP-A levels reflect the disease activity of IPF. In patients with IPF, serum SP-A concentrations were significantly correlated with those of serum lactate dehydrogenase, whereas there were no significant correlations of serum SP-A concentrations with erythrocyte sedimentation rate, arterial oxygen saturation, vital capacity and carbon monoxide diffusing capacity. Determination of serum SP-A will contribute to diagnosing IPF and PAP, and may reflect the disease activity of IPF.
Honda
Y
Y
Department of Third Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Kuroki
Y
Y
Shijubo
N
N
Fujishima
T
T
Takahashi
H
H
Hosoda
K
K
Akino
T
T
Abe
S
S
D015415:Biomarkers / Q000097:blood*; D001799:Blood Sedimentation; D004797:Enzyme-Linked Immunosorbent Assay; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008171:Lung Diseases / Q000097:blood; D010100:Oxygen / Q000097:blood; D011510:Proteolipids / Q000097:blood*; D011649:Pulmonary Alveolar Proteinosis / Q000097:blood / Q000175:diagnosis; D011653:Pulmonary Diffusing Capacity; D011658:Pulmonary Fibrosis / Q000097:blood* / Q000175:diagnosis*; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000097:blood*; D014797:Vital Capacity
D015415:Biomarkers; D006023:Glycoproteins; D011510:Proteolipids; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; D007770:L-Lactate Dehydrogenase; D010100:Oxygen