Role of endothelin in the exercise intolerance of chronic heart failure.
In conclusion, plasma levels of the endothelial-derived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise.
Krum
H
H
Center for Heart Failure Research, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Goldsmith
R
R
Wilshire-Clement
M
M
Miller
M
M
Packer
M
M
D000328:Adult; D000368:Aged; D016232:Endothelins / Q000097:blood*; D017079:Exercise Tolerance; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D011659:Pulmonary Gas Exchange; D014667:Vasopressins / Q000097:blood
D016232:Endothelins; D014667:Vasopressins; D009638:Norepinephrine