Low-affinity nerve growth factor receptor immunoreactivity in the human urinary bladder.
The localization of low-affinity nerve growth factor receptor (LNGFR) in the human urinary bladder was examined immunohistochemically using the mouse monoclonal antibody (ME20-4) against human LNGFR. LNGFR immunoreactivity was present in the human urinary bladder. The distribution of LNGFR-positive fibers was more abundant in the mucosa than in the muscle layer. Results also showed that some LNGFR-positive fiber bundles contained tyrosine hydroxylase immunoreactivity. Electron microscopic examination revealed that LNGFR immunoreactivity was located on the surface of Schwann cells, and frequently on the interface of axons and Schwann cells.
Wakabayashi
Y
Y
Department of Urology, Shiga University of Medical Science, Otsu, Japan.
Tomoyoshi
T
T
Tooyama
I
I
Kitahama
K
K
Kim
S U
SU
Maeda
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D001369:Axons / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D017475:Receptors, Nerve Growth Factor / Q000187:drug effects / Q000378:metabolism*; D012583:Schwann Cells / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D001743:Urinary Bladder / Q000201:enzymology / Q000294:innervation / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D017475:Receptors, Nerve Growth Factor; D014446:Tyrosine 3-Monooxygenase