Scanning electron microscope observation on tegumental alteration of Schistosoma japonicum induced by levo- and dextro-praziquantel.
When mice infected with Schistosoma japonicum for 35 d were treated ig with levo-praziquantel (L-Pra) 150 mg.kg-1 or dextro-praziquantel (D-Pra) 150-600 mg.kg-1, the alterations of the worm tegument were examined by scanning electron microscopy within 1-24 h after administration. The results showed that L-Pra induced apparent and extensive damage on the worm surface including severe swelling, fusion, erosion and peeling of tegument accompanied by attachment of the host leukocytes. The discoid-like sensory structures usually showed swelling, deformation and collapse. With D-Pra 150 mg.kg-1, only slight damage of tegument was seen. When the dose was increased to 600 mg.kg-1, the damage of worm tegument was similar to that induced by L-Pra 150 mg.kg-1 but the intensity of the damage was slighter as compared to that induced by L-Pra. The results suggested that the actions of the 2 optical enantiomers of praziquantel were different in quantity but not in quality.
Xiao
S
S
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
Shen
B
B
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D012549:Schistosoma japonicum / Q000187:drug effects / Q000648:ultrastructure*; D012554:Schistosomiasis japonica / Q000188:drug therapy*; D013237:Stereoisomerism
D011223:Praziquantel