Amyloid P component promotes aggregation of Alzheimer's beta-amyloid peptide.
Amyloid P component (AP) has been recognized as a beta-amyloid-associated protein but the pathological role is not known. In the present experiments, it has been shown that AP promotes the aggregation of Alzheimer's beta-amyloid peptide (A beta) in the presence of a physiological concentration of Ca2+. The aggregation promotion was observed at a concentration of soluble A beta 1-40 in human cerebrospinal fluid. The results suggest that AP is possibly a pathogenic factor of the cerebral amyloidosis.
Hamazaki
H
H
Department of Biology, Kitasato University School of Medicine, Kanagawa, Japan.
D016564:Amyloid beta-Protein Precursor / Q000134:cerebrospinal fluid / Q000737:chemistry* / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D000683:Serum Amyloid P-Component / Q000302:isolation & purification / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology
D016564:Amyloid beta-Protein Precursor; D000683:Serum Amyloid P-Component; D015032:Zinc