title: Platelet and endothelial response with trapidil in patients with peripheral obliterative arteriopathy.
abstract: The activity of trapidil, an antiaggregating agent with PDGF antagonist properties, was investigated in order to verify its possible modulating effect in the endothelial and platelet activation. PDGF, t-PA, PAI-1 and ET-1 plasma levels were measured before and after a 2 month treatment period with trapidil 200 mg tablets bid or placebo in 30 patients affected by POA in Fontaine stage II. PDGF and PAI-1 significantly (p < 0.05) increased in the placebo group, and PDGF also in the comparison between treatments (p < 0.05). Aggregation data demonstrate an absence of Ca++ antagonist action of trapidil. The results of this study suggest that trapidil can interfere with the combined vascular and platelet response in atherogenesis.
authors.affiliation: San Carlo Borromeo General Hospital, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bonfardeci
authors.forename: C
authors.initials: C
authors.lastname: Cimminiello
authors.forename: L
authors.initials: L
authors.lastname: Cantini
authors.forename: G
authors.initials: G
authors.lastname: Arpaia
authors.forename: M
authors.initials: M
authors.lastname: Aloisio
authors.forename: F
authors.initials: F
authors.lastname: Pozzi
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy*; D001792:Blood Platelets / Q000187:drug effects; D004311:Double-Blind Method; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000188:drug therapy*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D010959:Tissue Plasminogen Activator / Q000097:blood; D014192:Trapidil / Q000627:therapeutic use*
chemical_list: D016232:Endothelins; D017395:Plasminogen Activator Inhibitor 1; D010975:Platelet Aggregation Inhibitors; D010982:Platelet-Derived Growth Factor; D010959:Tissue Plasminogen Activator; D014192:Trapidil