Intercellular signaling. A kinase for cell-fate determination?
GSK-3, a ubiquitous kinase regulated by tyrosine phosphorylation, controls cell-fate decisions in both Drosophila and Dictyostelium; genetic analysis of its interactions with other signaling pathways is now possible.
Briscoe
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Department of Biology, University of California, San Diego, La Jolla 92093-0634, USA.
Firtel
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RA
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004023:Dictyostelium / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D004789:Enzyme Activation; D038362:Glycogen Synthase Kinase 3; D008954:Models, Biological; D008961:Models, Structural; D010766:Phosphorylation; D017433:Protein Structure, Secondary; D011953:Receptors, Cyclic AMP / Q000502:physiology; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism
D011953:Receptors, Cyclic AMP; D014443:Tyrosine; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3