title: [Preliminary clinical results of surgery for type A acute aortic dissections using gelatin-resorcin-formaldehyde glue].
abstract: We used gelatin-resorcin-form-aldehyde (GRF) glue to fuse the false lumen of type A acute aortic dissection in four patients. All were operated on within 3-24 hours after onset, and gluing of the two cylinders of the dissecting aorta could be done safely in a short time. Initial intimal tears were located in the transverse aorta in three patients and in the proximal descending aorta in one. Simple transection and end-to-end anastomosis of the ascending aorta was done for the first two cases. But in the last two patients, we resected the intimal tear in the transverse aorta and applied GRF glue to the stump of the aortic arch and to that of the aortic root, followed by graft replacement of the ascending aorta. There were no hospital deaths. But we had to reoperate on one patient five months after the first operation due to potentially residual dissection in the aortic root. GRF glue is a very useful adhesive for acute aortic dissection operations, but further refinement of the operative technique using it is necessary.
authors.affiliation: Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Hachiya
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Goto
authors.forename: A
authors.initials: A
authors.lastname: Mitsumaru
authors.forename: T
authors.initials: T
authors.lastname: Katogi
authors.forename: R
authors.initials: R
authors.lastname: Yozu
authors.forename: S
authors.initials: S
authors.lastname: Kawada
mesh_terms: D000208:Acute Disease; D000368:Aged; D000784:Aortic Dissection / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D005260:Female; D005557:Formaldehyde / Q000627:therapeutic use; D005780:Gelatin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012118:Resorcinols / Q000627:therapeutic use; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D012118:Resorcinols; D014014:Tissue Adhesives; D005557:Formaldehyde; D005780:Gelatin; C031389:resorcinol