title: ARIC hemostasis study--IV. Intraindividual variability and reliability of hemostatic factors. The Atherosclerosis Risk in Communities (ARIC).
abstract: We have recently reported the short-term intraindividual variability of several coagulation factors and inhibitors included in the ARIC study (Chambless et al. Ann Epidemiol 1992; 2:723). In this paper, we reported the intraindividual variability results of additional hemostatic factors. Blood samples were collected for hemostatic assays three times at 1-2-week intervals from 39 subjects recruited from 4 ARIC field centers. The contributions of within-person, processing and assay (designated "method") and between-person variances to the total variance were estimated and from them the reliability coefficient, R, was computed as the proportion of total variance in the between-person component. The R value was high for beta-thromboglobulin and tissue-plasminogen activator: 0.83 and 0.81, respectively; and intermediate for D-dimer and plasminogen activator inhibitor-1: 0.73 and 0.72, respectively. Protein S (total and free) and platelet factor 4 had low repeatability (R < 0.50) derived mostly from "method" variability while low R value (0.03) for fibrinopeptide A was attributed to high "method" and "within-person" variability. Gender, age and the level of hemostatic factors did not influence the intraindividual variability.
authors.affiliation: Division of Hematology, University of Texas Medical School, Houston 77030, USA.
authors.forename: N D
authors.initials: ND
authors.lastname: Nguyen
authors.forename: H
authors.initials: H
authors.lastname: Ghaddar
authors.forename: V
authors.initials: V
authors.lastname: Stinson
authors.forename: L E
authors.initials: LE
authors.lastname: Chambless
authors.forename: K K
authors.initials: KK
authors.lastname: Wu
mesh_terms: D001161:Arteriosclerosis / Q000097:blood*; D001779:Blood Coagulation Factors / Q000502:physiology*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology; D011446:Prospective Studies; D017293:Protein S / Q000378:metabolism; D012016:Reference Values; D015203:Reproducibility of Results; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001779:Blood Coagulation Factors; D017293:Protein S