Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase.
Devadas
B
B
Department of Medicinal and Structural Chemistry, G. D. Searle and Company, St. Louis, Missouri 63198, USA.
Zupec
M E
ME
Freeman
S K
SK
Brown
D L
DL
Nagarajan
S
S
Sikorski
J A
JA
McWherter
C A
CA
Getman
D P
DP
Gordon
J I
JI
D000217:Acyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000595:Amino Acid Sequence; D001665:Binding Sites; D002176:Candida albicans / Q000201:enzymology*; D004151:Dipeptides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D015195:Drug Design; D005656:Fungal Proteins / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D004151:Dipeptides; D005656:Fungal Proteins; D009842:Oligopeptides; D000217:Acyltransferases; C050480:glycylpeptide N-tetradecanoyltransferase