[Correcting effect of nicotinamide on hemoglobin glycosylation in streptozotocin diabetes in rats].
Streptozotocin induced diabetes in rats was accompanied by development of hyperglycemia, by increase in the rate of hemoglobin and albumin glycosylation in blood and by elevation of 2,3-diphosphoglycerate content in erythrocytes. Alterations of the dissociation properties and the decrease in Hb P50 value suggested the reduced affinity of hemoglobin to oxygen. Injection of nicotinamide, which is involved in NAD+ biosynthesis, caused a decrease of glucose content in blood, stabilized the content of 2,3-diphosphoglycerate and of glycosylated hemoglobin in erythrocytes. Nicotinamide appears to decrease the rate of hemoglobin glycosylation and enhanced the tissue oxygen utilization under hypoxic conditions.
Velikiĭ
N N
NN
Burda
V A
VA
Obrosova
I G
IG
Biront
N V
NV
Fedyk
M Ia
MIa
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D006031:Glycosylation; D006454:Hemoglobins / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009243:NAD / Q000096:biosynthesis; D009536:Niacinamide / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D006454:Hemoglobins; D009243:NAD; D009536:Niacinamide; D013311:Streptozocin; D010100:Oxygen
Korrigiruiushchiĭ éffekt nikotinamida na protsessy glikozilirovanniiagemoblogina pri streptozototsinovom diabete u krys.