title: Megaoesophagus and glucocorticoid-deficient hypoadrenocorticism in a dog.
abstract: A seven-year-old German shepherd dog was referred for acute onset regurgitation. Muscle weakness and severe dermatological disease were present. Thoracic radiographs revealed generalised megaoesophagus. Diagnostic testing revealed glucocorticoid deficiency, and rapid resolution of the megaoesophagus followed appropriate supplementation. The dog made a full recovery. Unique features of this case include a transiently positive antinuclear antibody titre and clinical features of myasthenia gravis.
authors.affiliation: Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: N T
authors.initials: NT
authors.lastname: Whitley
mesh_terms: D000309:Adrenal Insufficiency / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology*; D004285:Dogs; D004359:Drug Therapy, Combination; D004931:Esophageal Achalasia / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000662:veterinary; D008787:Metoclopramide / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D013902:Radiography, Thoracic / Q000662:veterinary; D012472:Salivation
chemical_list: D003907:Dexamethasone; D002927:Cimetidine; D000324:Adrenocorticotropic Hormone; D011239:Prednisolone; D008787:Metoclopramide