Effect of some sex steroid hormones on human spermatozoa migration in vitro.
The potential chemotactic effect of sex steroid hormones on human spermatozoa was studied. In an in vitro model, the number of human sperm cells migrating to Biggers-Whitten-Whittingham (BWW) medium containing progesterone in concentrations from 1 microgram/ml to 100 micrograms/ml was significantly higher than the number migrating to control medium (pure BWW). The presence of testosterone in the incubation medium decreases the migration of spermatozoa, and estradiol and estriol did not cause any visible changes in their behaviour. This effect of changes in migration was interpreted as chemotaxis of spermatozoa.
Sliwa
L
L
Department of Biology, Jagiellonian University School of Medicine, Kraków, Poland.
D000328:Adult; D002633:Chemotaxis / Q000187:drug effects* / Q000502:physiology; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D006801:Humans; D008297:Male; D011374:Progesterone / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D004964:Estriol