Yunnanxane and its homologous esters from cell cultures of Taxus chinensis var. mairei.
From cell cultures of Taxus chinensis var. mairei, yunnanxane [2 alpha, 5 alpha, 10-beta triacetoxy-14 beta-(2'-methyl-3'-hydroxyl)-butyryloxy-4(20),11-taxadiene, [1], and four new homologous esters, 2 alpha, 5 alpha, 10 beta, 14 beta- tetra-acetoxy-4(20),11-taxadiene [2], 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-propionyloxy-4(20),11-taxadiene [3], 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-isobutyryloxy-4(20),11- taxadiene [4], and 2 alpha, 5 alpha, 10 beta- triacetoxy-14 beta-(2'-methyl)-butyryloxy-4(20),11- taxadiene [5] have been isolated. Their structures were determined by spectroscopic methods.
Ma
W
W
PHYTOpharmaceuticals, Inc., San Carlos, California 94070-3312.
Stahlhut
R W
RW
Adams
T L
TL
Park
G L
GL
Evans
W A
WA
Blumenthal
S G
SG
Gomez
G A
GA
Nieder
M H
MH
Hylands
P J
PJ
D000972:Antineoplastic Agents, Phytogenic / Q000096:biosynthesis / Q000737:chemistry*; D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D018547:Plant Stems / Q000166:cytology / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D004952:Esters; C076298:yunnanxane