title: Multiple paraneoplastic syndromes in a patient with antibodies to neuronal nucleoproteins (anti-Hu).
abstract: We report the clinical and autopsy studies of a patient with an unusual combination of multiple paraneoplastic neurological syndromes in association with antibodies to a 35-40 kDa neuronal nucleo-protein (anti-Hu). Neurological disease preceded the detection of a small cell carcinoma of the lung. The patient had combined sensory and motor neuronopathy or neuropathy, cerebellar degeneration, brain-stem and limbic encephalitis, and clinical evidence of the Lambert-Eaton myasthenic syndrome and gastrointestinal pseudo-obstruction of paraneoplastic origin.
authors.affiliation: Neurologische Klinik, Medizinische Hochschule Hannover, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Heidenreich
authors.forename: R
authors.initials: R
authors.lastname: Schober
authors.forename: U
authors.initials: U
authors.lastname: Brinck
authors.forename: H P
authors.initials: HP
authors.lastname: Hartung
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western; D018288:Carcinoma, Small Cell; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009474:Neurons / Q000737:chemistry / Q000276:immunology*; D009698:Nucleoproteins / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000276:immunology* / Q000473:pathology
chemical_list: D001323:Autoantibodies; D009419:Nerve Tissue Proteins; D009698:Nucleoproteins