Estimation of the effective amount entering the body for drugs subject to enterohepatic recirculations.
A pharmacokinetic model is used to take into account multiple recirculations of drug occurring at various times after gall bladder emptying. If a dose D is initially administed, due to recirculation, an effective amount A* reaches the body. This value A* is expressed as a function of D and the model parameters, after oral administration or intravenous injection. Using areas under curves in two different situations, the reabsorption rate may be identified.
Plusquellec
Y
Y
UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
Houin
G
G
D000284:Administration, Oral; D000818:Animals; D004764:Enterohepatic Circulation / Q000502:physiology*; D006801:Humans; D007275:Injections, Intravenous; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010599:Pharmacokinetics; D010879:Piperazines / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats
D004364:Pharmaceutical Preparations; D010879:Piperazines; C059182:N,N'-dicyclopropylmethylpiperazine