title: Phencyclidine receptors in brain and spinal cord of spontaneously hypertensive rats aged 4-16 wk.
abstract: OBJECTIVE
  To study the relationship between the density of phencyclidine [1-(1-phenylcyclohexyl)piperidine hydrochloride, Phe] receptor binding sites in brain and thoracic spinal cord (T4-6) and the development of hypertension in spontaneously hypertensive rat (SHR).
  
  
  METHODS
  The density of Phe binding sites was determined by autoradiography using [3H]Phe in 4-, 8-, 12- and 16-wk-old rats.
  
  
  RESULTS
  There were fewer Phe binding sites in the hippocampus and dorsal horn of thoracic spinal cord of SHR at 12 and 16 wk (P < 0.01), when hypertension has established; while at 4 wk of age, before the development of hypertension, more Phe binding sites were found in SHR. As blood pressure began to rise at 8 wk, SHR had more Phe binding sites in hippocampus vs WKY, but no difference was seen between 2 strains in the dorsal horn of thoracic spinal cord.
  
  
  CONCLUSIONS
  Phe receptors might be involved in the genesis of SHR hypertension.
authors.affiliation: Department of Neurobiology, Shanghai Medical University, China.
authors.forename: X
authors.initials: X
authors.lastname: Yin
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhu
authors.forename: S F
authors.initials: SF
authors.lastname: Xu
mesh_terms: D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017478:Receptors, Phencyclidine / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D017478:Receptors, Phencyclidine