Effects of long-term vitamin E supplementation in alcoholic cirrhotics.
OBJECTIVE
Alcohol ingestion promotes lipoperoxidation and alters cellular antioxidant mechanisms. Alpha-tocopherol levels decrease in alcoholics as severity of liver damage increases. The aim of this protocol was to study the effects of a long-term oral 500 mg vitamin E daily supplementation in decompensated ambulatory alcoholic cirrhotics.


METHODS
67 subjects were included in this double blind trial; 33 patients received vitamin E and 34 patients received placebo tablets of identical appearance during 1 year. Each month, the patients were seen by a nurse practitioner who was in charge of detecting alcohol ingestion and checking adherence to treatment. Every 3 months, the patients underwent a medical examination, and blood samples were taken for clinical laboratory analysis and serum vitamin E measurement.


RESULTS
Alpha-tocopherol levels were significantly lower in patients with more severe liver disease. This difference was not significant when vitamin E levels were corrected by cholesterol. Oral supplementation significantly increased serum vitamin E levels in the experimental group. Alcohol ingestion and hospitalization rates were similar in both groups. Life table analysis did not show significant differences in mortality between the two groups.


CONCLUSIONS
Vitamin E supplementation with adequate doses of an alpha-tocopheryl acetate formulation during 1 year did not influence hepatic laboratory parameters, mortality or hospitalization rates of decompensated alcoholic cirrhotics, although serum levels of the vitamin significantly increased.
de la Maza
M P
MP
Institute of Nutrition and Food Technology, Faculty of Medicine, University of Chile, Santiago.
Petermann
M
M
Bunout
D
D
Hirsch
S
S
D000328:Adult; D001663:Bilirubin / Q000097:blood; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011517:Prothrombin Time; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D010919:Placebos; D014810:Vitamin E; D002784:Cholesterol; D001663:Bilirubin