Effects of danazol on thrombopoiesis in rats.
A synthetic analog of ethinyltestosterone, Danazol, has been used clinically for the treatment of immune thrombocytopenia. We investigated the effects of Danazol on thrombopoiesis in normal rats. Though 4-week treatment by Danazol slightly enhanced the DNA synthesizing enzyme activities and the number of S-phase cells in bone marrow and spleen, the number of megakaryocytes and thrombocytes were not increased in bone marrow and peripheral blood, respectively. These findings suggest that Danazol treatment will not induce thrombosis with thrombocytosis in normal human beings and animals.
Suzuki
S
S
Institute of Medical Technology, Bunkyo Jogakuin, Japan.
Kudo
H
H
Nakayama
T
T
Kuwa
K
K
Sugiura
Y
Y
Liu
L
L
Sakamoto
S
S
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001853:Bone Marrow / Q000187:drug effects / Q000201:enzymology; D001854:Bone Marrow Cells; D001973:Bromodeoxyuridine / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D003613:Danazol / Q000494:pharmacology*; D005260:Female; D008533:Megakaryocytes / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013927:Thrombosis / Q000139:chemically induced* / Q000662:veterinary; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000378:metabolism
D004247:DNA; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D001973:Bromodeoxyuridine; D003613:Danazol