Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism.
Ellouk-Achard
S
S
Université René-Descartes, Faculté de Pharmacie, Laboratoire de Toxicologie, France.
Levresse
V
V
Martin
C
C
Pham-Huy
C
C
Dutertre-Catella
H
H
Thevenin
M
M
Warnet
J M
JM
Claude
J R
JR
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002330:Carmustine / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D004734:Energy Metabolism / Q000187:drug effects*; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000037:antagonists & inhibitors; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000082:Acetaminophen; D008748:Methylcholanthrene; D005980:Glutathione Reductase; D005978:Glutathione; D002118:Calcium; D002330:Carmustine