Results from in vitro fertilization and intracytoplasmic sperm injection with purified gonadotrophins (Metrodin HP).
Purified urinary follicle-stimulating hormone (uFSH-HP; Metrodin HP, Serono Ltd.) was compared with a combination of pure FSH and human menopausal gonadotrophin (hMG; Pergonal, Serono Ltd.) in patients undergoing standard in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). In standard IVF, pure FSH gave a significantly higher pregnancy rate per started cycle than did the combination with hMG (35 vs. 18%, p < 0.05). No differences between standard IVF and ICSI were seen which could be associated with hormonal stimulation in an open non-randomized series of patients. In 11 ICSI cycles, the use of recombinant FSH (Gonal F, Serono Ltd.) resulted in 4 ongoing pregnancies.
Wikland
M
M
Fertility Center Scandinavia, Carlander's Hospital, Göteborg, Sweden.
Nilsson
L
L
Bergh
C
C
Hamberger
L
L
D003593:Cytoplasm; D004338:Drug Combinations; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D011247:Pregnancy; D011994:Recombinant Proteins; D012099:Reproductive Techniques; D013094:Spermatozoa
D004338:Drug Combinations; D011994:Recombinant Proteins; D008596:Menotropins; D005640:Follicle Stimulating Hormone