[Effectiveness of lignin as a protective factor in exposure to polychlorinated biphenyls].
The effect of lignin on some biochemical and morphological parameters was studied in rats after short-term treatment with the industrial mixture of polychlorinated biphenyls (PCB) sovol at a daily dose of 5 mg/kg, 5 times a week for a fortnight. Dietary supplementation of 5% lignin as the drug polyphenane did not protect the induction of the rat hepatic P-450 cytochrome monooxygenase system, which is typical of the action of PCB, but slightly modified the inducing effect of sovol. In the polyphepane-fed animals, there was a decrease in impairments of the liver structure and its more rapid normalization than in control rats. The lower hepatotoxic effect of the PCB mixture when lignin was added to the ration was likely to be associated with the action of lignin as a nonspecific polyvalent enterosorbent. It is concluded that polyphepane is a promising protective agent on exposure to PCB.
Tutel'ian
V A
VA
Lashneva
N V
NV
Gadzhieva
Z M
ZM
Vorobeĭchik
T A
TA
Shatrov
G N
GN
Smirnov
V G
VG
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D007928:Lethal Dose 50; D017705:Lignans / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D011041:Poisoning / Q000517:prevention & control; D011078:Polychlorinated Biphenyls / Q000506:poisoning*; D051381:Rats; D017208:Rats, Wistar
D017705:Lignans; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls
Effektivnost' lignina kak zashchitnogo faktora pri vozdeĭstvii polikhlorirovannykh bifenilov.