Polyclonal Mycobacterium avium infections in patients with AIDS: variations in antimicrobial susceptibilities of different strains of M. avium isolated from the same patient.
Broth microdilution MICs were determined for pairs of strains isolated from five AIDS patients with polyclonal Mycobacterium avium infection. Four (80%) of the five patients were infected simultaneously with strains having different antimicrobial susceptibility patterns. These findings have implications for the interpretation of susceptibility data in M. avium prophylaxis and treatment trials.
von Reyn
C F
CF
Infectious Disease Section, Dartmouth Medical School, Lebanon, New Hampshire, USA.
Jacobs
N J
NJ
Arbeit
R D
RD
Maslow
J N
JN
Niemczyk
S
S
D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000382:microbiology* / Q000517:prevention & control; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects* / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications* / Q000382:microbiology* / Q000517:prevention & control