Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C.
The mouse receptor tyrosine kinase (RTK) NEP, also called Ptk-3, is widely expressed, with high levels in proliferating neuroepithelia of mouse embryos. The recently described human discoidin domain receptor (DDR) has a predicted amino acid sequence 93% identical to that of murine NEP and may be its human homologue. We have mapped the gene encoding NEP in human and mouse by fluorescence in situ hybridization using a mouse cDNA probe. The NEP/Nep gene maps to human chromosome 6p21.3 and mouse chromosome 17C, respectively. This places the NEP/Nep gene at, or near, the major histocompatibility (MHC) locus--HLA in human and H2 in mouse, respectively. Based on its pattern of expression during development, NEP and Nep represent candidate genes for several MHC-linked developmental abnormalities in human and mouse.
Edelhoff
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Department of Pathology, University of Washington, Seattle 98195, USA.
Sweetser
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Disteche
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D000818:Animals; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D000070819:Discoidin Domain Receptor 1; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000201:enzymology; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
D006183:H-2 Antigens; D006680:HLA Antigens; C511169:DDR1 protein, rat; D000070819:Discoidin Domain Receptor 1; D020794:Receptor Protein-Tyrosine Kinases