Pulmonary host defenses.
Well functioning host defenses in the respiratory tract effectively remove microbes and other debris that reach the conducting airways and alveoli, and this usually prevents infections. People with acute and chronic illnesses can experience failure of any number of these defense mechanisms that allow pneumonia (and bacteremia) to occur, often with considerable morbidity and mortality. People with alcohol-related illnesses are a susceptible group for infections, and many strategies are needed to help them such as moderating alcohol abuse and dependence, providing timely immunizations to create antibody against encapsulated bacteria, anticipating microbial colonization of mucosal areas that can promote infection, giving excellent supporting medical care in crisis situations, and prescribing appropriate antibiotics. New approaches to boosting inflammatory reactions to control lung infections better with cytokines and new immunomodulator therapies must be investigated now.
Reynolds
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Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033, USA.
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D000437:Alcoholism / Q000276:immunology*; D001980:Bronchi / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007121:Immunocompetence / Q000276:immunology; D008168:Lung / Q000276:immunology; D009079:Mucociliary Clearance / Q000502:physiology; D018410:Pneumonia, Bacterial / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology*