Adhered platelet morphology in diabetes mellitus.
We compared the morphology of platelets obtained from diabetic patients in various stages of retinopathy and nephropathy with those of control patients. The platelets were collected on to polyethylene films, processed and observed under scanning electron microscopy. Different platelet morphologies were observed within the diabetic group, correlating with the severity of complications, whereas platelets appeared normal in the control group. After more extensive follow-up and comparative studies, these preliminary observations could provide another diagnostic tool for detecting and evaluating severe complications associated with diabetes.
Kim
S W
SW
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City 84108, USA.
Ryu
G H
GH
Lee
I
I
Koh
J J
JJ
Min
B G
BG
Lee
H K
HK
D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D010973:Platelet Adhesiveness / Q000502:physiology*; D016037:Single-Blind Method