title: Goodpasture's syndrome in childhood: treatment with plasmapheresis and immunosuppression.
abstract: Goodpasture's syndrome rarely affects children. Therefore, we present our experience in a young boy whose pulmonary hemorrhage was dramatically resolved by three plasma exchanges. We believe the hemorrhage was caused primarily by acute capillaritis. He received cytoxan and steroids and a series of plasma exchanges which removed/suppressed his anti-glomerular basement membrane (anti-GBM) antibody production. However, after a year, his renal function did not return, and he required renal transplantation and continues to do well.
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202-5283.
authors.forename: L J
authors.initials: LJ
authors.lastname: McCarthy
authors.forename: J
authors.initials: J
authors.lastname: Cotton
authors.forename: C
authors.initials: C
authors.lastname: Danielson
authors.forename: V
authors.initials: V
authors.lastname: Graves
authors.forename: J
authors.initials: J
authors.lastname: Bergstein
mesh_terms: D019867:Anti-Glomerular Basement Membrane Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D010951:Plasma Exchange; D011859:Radiography
chemical_list: D007166:Immunosuppressive Agents