title: Bordetella pertussis fur gene restores iron repressibility of siderophore and protein expression to deregulated Bordetella bronchiseptica mutants.
abstract: We report the isolation and preliminary phenotypic characterization of manganese-resistant Bordetella bronchiseptica mutants with respect to deregulation of siderophore and iron-regulated protein expression. The fur gene of Bordetella pertussis was cloned by genetic complementation of this deregulated phenotype and confirmed as fur by nucleotide sequence analysis.
authors.affiliation: Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
authors.forename: T J
authors.initials: TJ
authors.lastname: Brickman
authors.forename: S K
authors.initials: SK
authors.lastname: Armstrong
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D001483:Base Sequence; D001884:Bordetella / Q000235:genetics* / Q000378:metabolism; D016950:Bordetella bronchiseptica / Q000235:genetics / Q000378:metabolism; D001886:Bordetella pertussis / Q000235:genetics / Q000378:metabolism; D004352:Drug Resistance, Microbial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005816:Genetic Complementation Test; D007501:Iron / Q000378:metabolism*; D008345:Manganese / Q000494:pharmacology*; D008969:Molecular Sequence Data; D012097:Repressor Proteins / Q000235:genetics*; D017262:Siderophores / Q000096:biosynthesis; D013045:Species Specificity
chemical_list: D001426:Bacterial Proteins; D012097:Repressor Proteins; D017262:Siderophores; C068477:ferric uptake regulating proteins, bacterial; D008345:Manganese; D007501:Iron