[Evolution of levels of free thyroxine and thyrotropin in treated Cushing disease].
OBJECTIVE
Determine the frequency and changes in thyroid hormones in Cushing's disease.


METHODS
Free thyroxin and thyrotropin levels were measured in 11 patients (age range 17 to 60 years) with Cushing's disease both before and after resection of the pituitary adenoma.


RESULTS
Free thyroxin levels were low (8.3 to 11.7 pmol/l) in 7 patients. These patients had no clinical manifestations of hypothyroidism. In 4 patients, cure of the pituitary adenoma led to normalization of the thyroid hormones 10 days after operation (13 to 55 pmol/l); in the other cases surgical cure was unsuccessful and thyroxin levels remained low. Cortisol levels were finally normalized in these patients after irradiation of the pituitary, a second pituitary operation, or bilateral resection of the adrenal glands in 2 patients. Normal thyroxin levels were thus achieved. There was no correlation between serum cortisol and free thyroxin.


CONCLUSIONS
Thyroid hormones should be assayed regularly in patients with Cushing's disease as a supplementary control of treatment effectiveness.
Monguillon
P
P
Service d'Endocrinologie, Centre Hospitalier Universitaire Morvan, Brest.
Kerlan
V
V
Codet
J P
JP
Bercovici
J P
JP
D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000097:blood* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D012086:Reoperation; D012189:Retrospective Studies; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone
Evolution de la thyroxine libre et de la thyréostimuline au cours de la maladie de Cushing traitée.