[The pathomorphological changes in the kidneys of white mice with experimental trichocephaliasis and after the use of anthelmintic preparations].
The experiments were carried out with 170 white mice divided into 4 groups. The first group consisted on 72 intact animals, administered subcutaneous ivomek (0.01 ml/kg) and oxfendasole (10 mg/kg) per os; Group 2 consisted of 15 animals with induced trichocephaliasis, administered no anthelmintics. The third group, 72 animals, were infected with Trichocephalus muris invasion eggs and administered anthelminthic agents on day 46 postinfection. The fourth group consisted of 11 intact animals, neither infected, nor treated (reference group). The animals were decapitated 3, 12, 24 and 72 h after the drug administration and histologic examination of the kidneys was carried out. The findings evidence that the morphologic changes in the kidneys of mice with trichocephaliasis are characterized by alternating proliferative processes. Both the drugs used were found characterized by a more or less pronounced nephrotoxicity. Ivomek induced the most marked structural changes in the kidneys of intact animals. The changes in the kidneys of intact mice were more manifest after the drugs administration than in intact animals.
Chebyshev
N V
NV
Berechikidze
I A
IA
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use* / Q000633:toxicity; D001562:Benzimidazoles / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D007559:Ivermectin / Q000627:therapeutic use* / Q000633:toxicity; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D051379:Mice; D013997:Time Factors; D014257:Trichuriasis / Q000188:drug therapy* / Q000473:pathology*
D000871:Anthelmintics; D001562:Benzimidazoles; D007559:Ivermectin; C011030:oxfendazole
Patomorfologicheskie izmeneniia v pochkakh belykh mysheĭ pri éksperimental'nom trikhotsefaleze i posle primeneniia antigel'mintnykh preparatov.