Absence of 4,977-bp deletion of blood cell mitochondrial DNA in patients with young-onset Parkinson's disease.
Decreased mitochondrial Complex I activities and a 4,977-bp deletion in mitochondrial DNA (mtDNA) have been reported in patients with Parkinson's disease. Based on the assumption of possible links between this 4,977-bp deletion and the etiology of Parkinson's disease, we analyzed mtDNA of blood cells from 15 patients with young-onset Parkinson's disease after the DNA was amplified by polymerase chain reaction. We could not detect the 4,977-bp mtDNA deletion in any of these patients. This result suggests that Parkinson's disease is not a mitochondrial disease due to the 4,977-bp mtDNA deletion. The 4,977-bp deletion in mtDNA appears to be an age-related phenomenon.
Shan
D E
DE
Neurological Institute, Veterans General Hospital, Taipei, Taiwan, ROC.
Yeh
S I
SI
Wan
Y C
YC
Wei
Y H
YH
D000328:Adult; D000367:Age Factors; D001482:Base Composition / Q000235:genetics; D001773:Blood Cells; D002872:Chromosome Deletion; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D016133:Polymerase Chain Reaction
D004272:DNA, Mitochondrial; D016660:NAD(P)H Dehydrogenase (Quinone)