Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas.
SAS is a recently identified member of the transmembrane 4 superfamily (TM4SF) that is frequently amplified in human sarcomas. To further its characterization and to confirm its classification, the genomic structure of the SAS gene was determined. The SAS gene covers approximately 3.2 kb of DNA. It contains six exons within its translated region, three of which are highly conserved in the TM4SF. 5' to the translation start site are two putative transcription start sites, two CCAAT consensus sequences, and potential binding sites for both Sp1 and ATF transcription factors. Comparison of SAS organization to human ME491, CD9, and CD53 and murine CD53 and TAPA-1 confirms that SAS is a member of this family of genes and is consistent with the theory that these genes arose through duplication and divergent evolution.
Jankowski
S A
SA
University of Michigan, Department of Human Genetics, Ann Arbor 48109, USA.
De Jong
P
P
Meltzer
P S
PS
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D001483:Base Sequence; D016384:Consensus Sequence; D004247:DNA / Q000235:genetics; D005091:Exons / Q000235:genetics; D005784:Gene Amplification; D005796:Genes; D006801:Humans; D007438:Introns / Q000235:genetics; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000235:genetics*; D010802:Phylogeny; D010980:Platelet Membrane Glycoproteins / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D012509:Sarcoma / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D060265:Tetraspanin 25; D060225:Tetraspanin 28; D060245:Tetraspanin 29; D060149:Tetraspanin 30; D059470:Tetraspanins
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C554894:CD53 protein, human; C554586:CD63 protein, human; C554798:CD81 protein, human; C554869:CD9 protein, human; C554895:Cd53 protein, mouse; C554587:Cd63 protein, mouse; C554799:Cd81 protein, mouse; C554870:Cd9 protein, mouse; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D010980:Platelet Membrane Glycoproteins; C086385:TSPAN31 protein, human; D060265:Tetraspanin 25; D060225:Tetraspanin 28; D060245:Tetraspanin 29; D060149:Tetraspanin 30; D059470:Tetraspanins; D004247:DNA