An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma.
In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml-1 has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.
O'Hanlon
D M
DM
Department of Surgery, University College Hospital, Galway, Ireland.
Kerin
M J
MJ
Kent
P
P
Maher
D
D
Grimes
H
H
Given
H F
HF
D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D017698:Postmenopause; D011237:Predictive Value of Tests; D017697:Premenopause; D011960:Receptors, Estrogen / Q000032:analysis; D012680:Sensitivity and Specificity
D018396:Mucin-1; D011960:Receptors, Estrogen