Four-helix bundle growth factors and their receptors: protein-protein interactions.
Many growth factors and cytokines promote receptor clustering on binding. At least three different protein-protein interaction sites are involved: cytokine-receptor I, cytokine-receptor II and receptor I-receptor II. Although structural data on these complexes are limited, recent structural and mutagenesis studies of the four-helix bundle class of cytokines are clarifying the nature of the complexes formed.
Mott
H R
HR
University of Oxford, UK.
Campbell
I D
ID
D000818:Animals; D016207:Cytokines / Q000737:chemistry / Q000378:metabolism; D006133:Growth Substances / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D011487:Protein Conformation; D018121:Receptors, Cytokine / Q000737:chemistry / Q000378:metabolism; D017978:Receptors, Growth Factor / Q000737:chemistry* / Q000378:metabolism*
D016207:Cytokines; D006133:Growth Substances; D018121:Receptors, Cytokine; D017978:Receptors, Growth Factor