Correction of anaemia and thrombocytopenia in a case of adult type I osteopetrosis with recombinant human erythropoietin (rHuEPO).
A case of adult osteopetrosis Type I was diagnosed in a 22-year-old female. She presented for investigation of anaemia with 'myelophthisic' characteristics and extramedullary haemopoiesis which was resistant to haematinics, nandrolone and low-dose corticosteroids. She became progressively transfusion-dependent with gradually worsening thrombocytopenia. She was successfully treated with recombinant erythropoietin. Anaemia as well as thrombocytopenia were corrected. There appeared to be a synergistic action of erythropoietin with steroids.
Meletis
J
J
First Department of Internal Medicine,University of Athens School of Medicine, Laikon General Hospital, Greece.
Samarkos
M
M
Michali
E
E
Vavourakis
S
S
Meletis
C
C
Poziopoulos
C
C
Stavrogianni
N
N
Konstantopoulos
K
K
Vaiopoulos
G
G
Yataganas
X
X
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000628:therapy*; D001855:Bone Marrow Diseases / Q000150:complications / Q000628:therapy; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010022:Osteopetrosis / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy*
D011994:Recombinant Proteins; D004921:Erythropoietin