title: Abu Dhabi third stage trial: oxytocin versus Syntometrine in the active management of the third stage of labour.
abstract: OBJECTIVE
  To compare the effect of oxytocin and Syntometrine when used as part of active management of third stage of labour on postpartum haemorrhage, hypertension, nausea/vomiting and retained placenta.
  
  
  METHODS
  A randomised double blind trial was conducted in the Obstetric Unit of Corniche Hospital, Abu Dhabi in the United Arab Emirates. Between 1 January 1991 and 30 June 1991, 2040 women were randomly allocated either to the oxytocin (n = 1017) or the Syntometrine (n = 1023) group. Twelve patients had to be excluded from the trial (oxytocin, 5; Syntometrine, 7) after randomisation because they no longer fulfilled the inclusion criteria. All women in the trial received either oxytocin 10 units or Syntometrine 1 ml (oxytocin 5 units+ergometrine (ergonovine) 0.5 mg) by intramuscular injection with delivery of the anterior shoulder of the baby. Relative risk with 95% confidence intervals was calculated for each variable.
  
  
  RESULTS
  Oxytocin (10 units) alone was as effective as Syntometrine (1 ml) in preventing post-partum haemorrhage without an increase in the incidence of retained placenta. Median blood loss was similar in both groups. The incidences of nausea, vomiting and headache were significantly lower in the oxytocin group, as was the occurrence of a mean rise in diastolic and systolic blood pressures of 20 and 30 mmHg or more, respectively.
  
  
  CONCLUSIONS
  Prophylactic administration of oxytocin 10 U in the third stage of labour, as part of active management, reduces the incidence of maternal nausea, vomiting, headache and rise in blood pressure than does Syntometrine 1 ml without adversely affecting the rate of post partum haemorrhage.
authors.affiliation: Corniche Hospital, Abu Dhabi, United Arab Emirates.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Khan
authors.forename: I S
authors.initials: IS
authors.lastname: John
authors.forename: T
authors.initials: T
authors.lastname: Chan
authors.forename: S
authors.initials: S
authors.lastname: Wani
authors.forename: A O
authors.initials: AO
authors.lastname: Hughes
authors.forename: G M
authors.initials: GM
authors.lastname: Stirrat
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004874:Ergonovine / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007749:Labor Stage, Third; D010120:Oxytocics / Q000009:adverse effects / Q000627:therapeutic use*; D010121:Oxytocin / Q000008:administration & dosage* / Q000009:adverse effects; D006473:Postpartum Hemorrhage / Q000517:prevention & control*; D011247:Pregnancy; D016896:Treatment Outcome; D014479:United Arab Emirates
chemical_list: D010120:Oxytocics; C038346:syntometrine; D010121:Oxytocin; D004874:Ergonovine