Lung cancer: reproducibility of quantitative measurements for evaluating 2-[F-18]-fluoro-2-deoxy-D-glucose uptake at PET.
OBJECTIVE
To study the precision of repeated 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) uptake measurements at positron emission tomography (PET) in patients with primary lung cancer.


METHODS
Ten patients with untreated lung cancer underwent two dynamic FDG PET examinations after a 4-hour fast within 1 week. Kinetic modeling of tumor FDG uptake was performed on the basis of a three-compartment model. The tumor concentration of F-18 (standardized uptake value calculated on the basis of predicted lean body mass [SUV-lean]) was also measured 50-60 minutes after injection of a tracer. Blood glucose, insulin, and free fatty acid levels were monitored.


RESULTS
SUV-lean and the FDG influx constant Ki were measured with a mean +/- standard deviation difference of 10% +/- 7 and 10% +/- 8, respectively, over repeated PET scans. The mean difference was reduced to 6% +/- 6 and 6% +/- 5 by multiplying SUV-lean and Ki by plasma glucose concentration.


CONCLUSIONS
SUV-lean and graphical Ki can be measured reproducibly, supporting their use in quantitative FDG PET algorithms.
Minn
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Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028, USA.
Zasadny
K R
KR
Quint
L E
LE
Wahl
R L
RL
D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007328:Insulin / Q000032:analysis; D008175:Lung Neoplasms / Q000097:blood / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005462:Fluorine Radioisotopes; D007328:Insulin; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose