title: [Antral gastritis in chronic alcoholism. Role of cirrhosis and Helicobacter pylori].
abstract: OBJECTIVE
  Antral gastritis is frequent in alcoholics. The role of H. pylori in the pathogenesis of gastritis in these patients is not well known. The aim of our study was to study the role of H. pylori and cirrhosis in the pathogenesis of antral gastritis in alcoholic patients.
  
  
  METHODS
  Seventy-nine patients were included in the study. All underwent upper gastrointestinal tract endoscopy with antral biopsies, independently of the presence of abdominal pain, and had serological examination for H. pylori antibodies.
  
  
  RESULTS
  Cirrhosis and gastritis were present in 50 and 40 patients respectively, H. pylori serological assay and histological identification of the bacterium were positive in 35 (44%) and 19 (24%) patients respectively. Discrepancy between the 2 tests were observed more frequently in cirrhotic patients. A positive serology with a negative histologic examination for H. pylori was present for 18 cirrhotic and 4 noncirrhotic patients (p < 0.05). A gastritis without evidence of H. pylori was more frequent in cirrhotic than in noncirrhotic patients. H. pylori was histologically present in 11 of 29 cirrhotic patients and in 8 of the 11 noncirrhotic patients with a gastritis (p < 0.05).
  
  
  CONCLUSIONS
  Discrepancies between histological examination and H. pylori serology in patients with cirrhosis might be due to the inhospitable environment for H. pylori in case of portal hypertension; the positive serology could be in relation with a past infection.
authors.affiliation: Service d'Hépato-Gastroentérologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre.
authors.forename: C
authors.initials: C
authors.lastname: Altman
authors.forename: A
authors.initials: A
authors.lastname: Ladouch
authors.forename: M J
authors.initials: MJ
authors.lastname: Briantais
authors.forename: T
authors.initials: T
authors.lastname: Rason
authors.forename: E
authors.initials: E
authors.lastname: Martin
authors.forename: L
authors.initials: L
authors.lastname: Jacques
authors.forename: C
authors.initials: C
authors.lastname: Buffet
mesh_terms: D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D005756:Gastritis / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000209:etiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011706:Pyloric Antrum / Q000382:microbiology / Q000473:pathology*
chemical_list: D000431:Ethanol
vernacular_title: Gastrite antrale au cours de l'alcoolisme chronique. Rôle de la cirrhose et d'Helicobacter pylori.