title: Developmental changes of alpha 1-adrenergic chronotropic action on human sinus node.
abstract: The important role of alpha 1-adrenoceptors in reperfusion ventricular arrhythmia is mentioned in the introduction. However, the present report is concerned with the sinus node. It is speculated that the decreased positive chronotropic action of alpha 1-adrenergic stimulation due to aging may contribute to the development of sick sinus syndrome.
authors.affiliation: First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Saitoh
authors.forename: A
authors.initials: A
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Osaka
authors.forename: N
authors.initials: N
authors.lastname: Sasabe
authors.forename: H
authors.initials: H
authors.lastname: Atarashi
authors.forename: H
authors.initials: H
authors.lastname: Hayakawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology*; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology*; D012849:Sinoatrial Node / Q000187:drug effects / Q000503:physiopathology
chemical_list: D018340:Receptors, Adrenergic, alpha-1; D010656:Phenylephrine