Reactions of copper(II)-oligopeptide complexes with hydrogen peroxide: effects of biological reductants.
Cu(II) complexes with oligopeptides containing histidyl residue in the second or third position could scarcely activate hydrogen peroxide (H2O2), but they could activate H2O2 to yield hydroxyl radical (.OH) in the presence of biological reductants such as cysteine and ascorbic acid. Further, DNA single strand breakage was also observed during the reactions of Cu(II)-glycylglycylhistidylglycine (GGHG) with H2O2 in the presence of same biological reductants.
Ueda
J
J
National Institute of Radiological Sciences, Chiba-shi, Japan.
Shimazu
Y
Y
Ozawa
T
T
D000595:Amino Acid Sequence; D000975:Antioxidants; D001205:Ascorbic Acid; D003300:Copper / Q000737:chemistry*; D003543:Cysteamine; D003545:Cysteine; D004249:DNA Damage; D004578:Electron Spin Resonance Spectroscopy; D005978:Glutathione; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical; D007700:Kinetics; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry*; D010084:Oxidation-Reduction; D010396:Penicillamine
D000975:Antioxidants; D009842:Oligopeptides; D017665:Hydroxyl Radical; D003543:Cysteamine; D003300:Copper; D006861:Hydrogen Peroxide; D005978:Glutathione; D010396:Penicillamine; D003545:Cysteine; D001205:Ascorbic Acid