title: Central alveolar hypoventilation associated with paraneoplastic brain-stem encephalitis and anti-Hu antibodies.
abstract: We describe a patient with a paraneoplastic brain-stem encephalitis due to an occult small cell carcinoma of the lung. He developed episodes of central sleep apnoea culminating in acute respiratory failure. Antibodies resembling anti-Hu antibodies were demonstrated in both serum and cerebrospinal fluid.
authors.affiliation: Department of Neurology, St Mary's Hospital, London, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Ball
authors.forename: T
authors.initials: T
authors.lastname: Warner
authors.forename: P
authors.initials: P
authors.lastname: Reid
authors.forename: R S
authors.initials: RS
authors.lastname: Howard
authors.forename: N A
authors.initials: NA
authors.lastname: Gregson
authors.forename: M N
authors.initials: MN
authors.lastname: Rossor
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis*; D001933:Brain Stem; D018288:Carcinoma, Small Cell / Q000150:complications*; D002531:Cerebellum / Q000276:immunology; D051959:ELAV Proteins; D004660:Encephalitis / Q000276:immunology*; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D016601:RNA-Binding Proteins / Q000276:immunology*; D051381:Rats; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins