title: Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X1005. Implications for biological regulation of 5-lipoxygenase.
authors.affiliation: Institute for Cardiovascular and Arteriosclerosis Research, Bayer AG, Wuppertal, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Hatzelmann
authors.forename: R
authors.initials: R
authors.lastname: Fruchtmann
authors.forename: K H
authors.initials: KH
authors.lastname: Mohrs
authors.forename: S
authors.initials: S
authors.lastname: Raddatz
authors.forename: M
authors.initials: M
authors.lastname: Matzke
authors.forename: U
authors.initials: U
authors.lastname: Pleiss
authors.forename: J
authors.initials: J
authors.lastname: Keldenich
authors.forename: R
authors.initials: R
authors.lastname: Müller-Peddinghaus
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D002352:Carrier Proteins; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D011804:Quinolines; C079315:2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid; D001094:Arachidonate 5-Lipoxygenase