Production of the staurosporine aglycon K-252c with a blocked mutant of the staurosporine producer strain Streptomyces longisporoflavus and by biotransformation of staurosporine with Streptomyces mediocidicus ATCC 13279.
Goeke
K
K
Ciba-Geigy AG, Pharmaceutical Division, Basel, Switzerland.
Hoehn
P
P
Ghisalba
O
O
D000470:Alkaloids / Q000378:metabolism*; D002227:Carbazoles / Q000378:metabolism*; D026121:Indole Alkaloids; D009154:Mutation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D019311:Staurosporine; D013302:Streptomyces / Q000378:metabolism
D000470:Alkaloids; D002227:Carbazoles; D026121:Indole Alkaloids; C049985:staurosporine aglycone; D011493:Protein Kinase C; D019311:Staurosporine