title: Fibroid growth in response to high-dose progestogen.
abstract: OBJECTIVE
  To challenge the conventional belief that leiomyomata are estrogen-dependent tumors by presentation of a case report suggesting high-dose progestogen therapy is associated with a dramatic increase in size of a fibroid uterus.
  
  
  METHODS
  Case report.
  
  
  METHODS
  British university hospital.
  
  
  METHODS
  One white woman treated with tamoxifen and high-dose megestrol acetate for breast carcinoma.
  
  
  METHODS
  Megestrol acetate therapy withdrawn.
  
  
  METHODS
  Uterine size.
  
  
  RESULTS
  While taking tamoxifen and high-dose megestrol acetate, the patient suffered a dramatic increase in size of her fibroid uterus, which reversed when the progestogen was withdrawn.
  
  
  CONCLUSIONS
  This case report suggests that P may be important in fibroid growth.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Harrison-Woolrych
authors.forename: R
authors.initials: R
authors.lastname: Robinson
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy; D002277:Carcinoma / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging*; D008535:Megestrol / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D019290:Megestrol Acetate; D008875:Middle Aged; D011372:Progestins / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D011372:Progestins; D013629:Tamoxifen; D008535:Megestrol; D019290:Megestrol Acetate