title: Tonic pupil and orbital glial-neural hamartoma in infancy.
abstract: OBJECTIVE
  Tonic pupils in early childhood are rare. We studied an otherwise healthy 31/2-month-old girl who had a right pupil that was poorly reactive to light, without other signs of oculomotor nerve palsy.
  
  
  CONCLUSIONS
  Constriction of the right pupil after instillation of 0.125% pilocarpine eyedrops confirmed denervation hypersensitivity, consistent with a tonic pupil. There was no strabismus or proptosis. A magnetic resonance imaging scan demonstrated a right orbital mass, interposed between the lateral and inferior recti muscles. Biopsy was consistent with a benign, glial-neural hamartoma. Thus, in this young patient, a tonic pupil was associated with a benign orbital mass.
authors.affiliation: Neurology Service, University of Pennsylvania School of Medicine, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Brooks-Kayal
authors.forename: G T
authors.initials: GT
authors.lastname: Liu
authors.forename: S J
authors.initials: SJ
authors.lastname: Menacker
authors.forename: K L
authors.initials: KL
authors.lastname: Heher
authors.forename: J A
authors.initials: JA
authors.lastname: Katowitz
authors.forename: L T
authors.initials: LT
authors.lastname: Bilaniuk
mesh_terms: D002675:Child, Preschool; D005260:Female; D006222:Hamartoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009457:Neuroglia / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D009915:Orbit / Q000473:pathology; D009916:Orbital Diseases / Q000150:complications / Q000175:diagnosis*; D015845:Tonic Pupil / Q000175:diagnosis* / Q000209:etiology