Deterministic models for the eradication of poliomyelitis: vaccination with the inactivated (IPV) and attenuated (OPV) polio virus vaccine.
Currently two polio vaccines, IPV and OPV, are in use which differ markedly in their epidemiological parameters. A simple epidemiological model in terms of ordinary differential equations is proposed to study the effects of vaccination campaigns using these vaccines. The numbers of interest are the reproduction number of the disease in the presence of vaccination and the critical vaccination coverage necessary to prevent an outbreak. For these numbers explicit representations are determined which can be used in comparing different vaccination strategies.
Eichner
M
M
Institut für Medizinische Biometrie, Universität Tübingen, Germany.
Hadeler
K P
KP
D000328:Adult; D002648:Child; D003906:Developing Countries; D004196:Disease Outbreaks / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D008954:Models, Biological; D011051:Poliomyelitis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D011054:Poliovirus Vaccine, Inactivated / Q000494:pharmacology; D011055:Poliovirus Vaccine, Oral / Q000494:pharmacology
D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral