title: In vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent.
abstract: This study evaluated the in vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent. The drug inhibited all tested members of the family Enterobacteriaceae at < or = 0.5 microgram/ml and all tested Pseudomonas aeruginosa, Burkholderia (Pseudomonas) cepacia, and Xanthomonas maltophilia strains at < or = 2 micrograms/ml. All but two strains of gram-positive bacteria were inhibited by < or = 1 microgram of the new drug per ml, including isolates highly resistant to ciprofloxacin.
authors.affiliation: Department of Medicine, Deaconess Hospital, Boston, Massachusetts 02215, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
authors.forename: C B
authors.initials: CB
authors.lastname: Wennersten
authors.forename: G
authors.initials: G
authors.lastname: Cole
authors.forename: D
authors.initials: D
authors.lastname: Chu
authors.forename: D
authors.initials: D
authors.lastname: Pizzuti
authors.forename: R C
authors.initials: RC
authors.lastname: Moellering
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000494:pharmacology*; D011807:Quinolizines / Q000494:pharmacology*
chemical_list: C094159:A 86719.1; D000900:Anti-Bacterial Agents; D011728:Pyridones; D011807:Quinolizines