title: XB/U-cadherin mRNA contains cytoplasmic polyadenylation elements and is polyadenylated during oocyte maturation in Xenopus laevis.
abstract: Cytoplasmic polyadenylation elements (CPE) are distinct sequence motifs in the 3'-untranslated region of mRNAs. They control translation of these RNAs by cytoplasmic polyadenylation. We show that the mRNA of the cell adhesion molecule XB/U-cadherin contains two CPE motifs. With oocyte maturation this mRNA becomes polyadenylated and increasingly recruited into the polysomal fraction. Our results give evidence that CPEs of the XB/U-cadherin mRNA are responsible for the XB/U-cadherin protein increase during oocyte maturation.
authors.affiliation: Abteilung Biochemie, Universität Ulm, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kühl
authors.forename: D
authors.initials: D
authors.lastname: Wedlich
mesh_terms: D000818:Animals; D001483:Base Sequence; D015820:Cadherins / Q000235:genetics*; D003593:Cytoplasm / Q000378:metabolism*; D018076:DNA, Complementary; D008969:Molecular Sequence Data; D009865:Oocytes / Q000254:growth & development / Q000378:metabolism*; D011061:Poly A / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D029867:Xenopus Proteins; D014982:Xenopus laevis
chemical_list: D015820:Cadherins; D018076:DNA, Complementary; D012333:RNA, Messenger; C093989:XB-U-cadherin protein, Xenopus; D029867:Xenopus Proteins; D011061:Poly A