title: Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.
abstract: Infection by human immunodeficiency virus type 1 (HIV-1) causes acquired immunodeficiency syndrome (AIDS) after a long clinical latency. This disease is associated with a spectrum of cancers. Here we report that wild-type p53 is a potent suppressor of Tat, a major transactivator of HIV-1. Reciprocally, Tat inhibits the transcription of p53. Downregulation of p53 by upregulated tat may be important for the establishment of productive viral infection in a cell and also may be involved in the development of AIDS-related malignancies.
authors.affiliation: Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: D J
authors.initials: DJ
authors.lastname: Friedman
authors.forename: A B
authors.initials: AB
authors.lastname: Pardee
mesh_terms: D001483:Base Sequence; D018076:DNA, Complementary; D015536:Down-Regulation; D015696:Gene Products, tat / Q000235:genetics / Q000502:physiology*; D016158:Genes, p53; D015756:Genes, tat; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D015533:Transcriptional Activation; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*; D054322:tat Gene Products, Human Immunodeficiency Virus
chemical_list: D018076:DNA, Complementary; D015696:Gene Products, tat; D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; D054322:tat Gene Products, Human Immunodeficiency Virus