Hyperhomocysteinaemia: a role in the accelerated atherogenesis of chronic renal failure?
Moderate hyperhomocysteinaemia has recently been established as an independent risk factor for atherothrombotic disease. It might be caused by heterozygosity for cystathionine beta-synthase deficiency, an enzyme involved in the conversion of methionine to cysteine through the transsulphuration pathway or by inherited thermolability of the enzyme which remethylates homocysteine into methionine. In chronic renal failure (CRF) homocysteine levels are significantly elevated at a relatively early stage. The normal kidney possibly plays an important role in homocysteine catabolism, which cannot be performed in CRF. Alternatively, decreased extrarenal catabolism can contribute to the hyperhomocysteinaemia in this disease state. Treatment with folic acid, 5 mg daily, significantly lowers homocysteine levels in chronic renal patients.
Janssen
M J
MJ
ICaR-VU, Department of Internal Medicine, University Hospital, Free University, Amsterdam, Netherlands.
van den Berg
M
M
Stehouwer
C D
CD
Boers
G H
GH
D000328:Adult; D000367:Age Factors; D001161:Arteriosclerosis / Q000209:etiology*; D003541:Cystathionine beta-Synthase / Q000172:deficiency / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006579:Heterozygote; D006710:Homocysteine / Q000097:blood* / Q000378:metabolism; D006712:Homocystinuria / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000378:metabolism; D008745:Methylation; D008875:Middle Aged; D006435:Renal Dialysis; D012737:Sex Factors
D006710:Homocysteine; D005492:Folic Acid; D008715:Methionine; D003541:Cystathionine beta-Synthase; D003545:Cysteine