title: Pre-exposure of mice to low dose or low dose rate ionizing radiation reduces chromosome aberrations induced by subsequent exposure to high dose of radiation or mitomycin C.
abstract: The phenomenon of cytogenetic adaptive and cross-adaptive response induced by low dose irradiation and chemical mutagen in mice is described. We found, firstly, that adaptation can be induced by acute low dose X-irradiation (0-100 mGy). Secondly, a cross-adaptation can occur between X-irradiation and mitomycin C (MMC). And finally, mice pre-exposed to chronic low dose rate 60Co-Gamma irradiation (0-226.0 mGy/day) are less susceptible to chromosome aberration induced by subsequent acute higher X-irradiation. Therefore, our data suggest that radioadaptive response depends on dose, dose rate and time interval. Possible mechanisms are also discussed.
authors.affiliation: Institute of Radiation Medicine, CAMS, Tianjin.
authors.forename: W
authors.initials: W
authors.lastname: Yu
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Cai
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002869:Chromosome Aberrations / Q000502:physiology; D003035:Cobalt; D005260:Female; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016685:Mitomycin / Q000009:adverse effects*; D011829:Radiation Dosage
chemical_list: D003035:Cobalt; D016685:Mitomycin