Comparison of birth weight distributions between Chinese and Caucasian infants.
To assess the reasons for the Chinese-Caucasian differences in birth weight distributions, a cohort study was carried out involving 18,665 Caucasian and 1,597 immigrant Chinese infants born at Montreal's Royal Victoria Hospital from January 1978 to March 1990 and 1,862 native Chinese infants born at Hefei Maternal and Infant Hospital in Hefei, People's Republic of China, from September 1990 to August 1991. Mean (standard deviation) birth weights in grams were 3,369 (567), 3,195 (493), and 3,171 (428) (p < 0.01 for differences in mean and variance), and mean (standard deviation) fetal growth ratios (ratio of observed birth weight to average birth weight at the same gestational age) were 0.994 (0.124), 0.963 (0.114), and 0.935 (0.112) (p < 0.01 for differences in mean and variance), respectively, in the Caucasian, immigrant Chinese, and native Chinese groups. No important or consistent Chinese-Caucasian differences in gestational age were found. When mothers with extreme values for demographic, anthropometric, nutritional, and lifestyle determinants of fetal growth were excluded, the mean fetal growth ratio in Caucasian infants remained significantly higher (p < 0.01), but the standard deviations became more similar (p > 0.05): Mean (standard deviation) fetal growth ratios were 1.001 (0.111), 0.966 (0.108), and 0.946 (0.114), respectively. The race-specific rate of growth differed according to period of gestation, with Chinese infants showing more rapid fetal growth early in the third trimester but slower growth near and after term. The authors conclude that the lower mean birth weight in Chinese infants is due to differences in fetal growth (rather than gestational duration) and by their inherently slower growth at or after term. The tight distribution of birth weight among the Chinese is caused partly by their reduced exposure to extremes of maternal determinants of fetal growth (mediated largely by environmental mechanisms) and partly by their inherently different growth pattern, with faster growth at earlier gestations but slower growth at later gestations.
Wen
S W
SW
Department of Epidemiology and Biostatistics, McGill University Faculty of Medicine, Montreal, Quebec, Canada.
Kramer
M S
MS
Usher
R H
RH
D000704:Analysis of Variance; D044466:Asian People; D001724:Birth Weight; D002681:China; D015331:Cohort Studies; D003710:Demography; D005314:Embryonic and Fetal Development; D004641:Emigration and Immigration; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy / Q000502:physiology; D011792:Quebec; D044465:White People