Alcohol drinking in rats injected ICV with 6-OHDA: effect of 8-OHDPAT and tropisetron (ICS 205930).
6-Hydroxydopamine (6-OHDA) was administered ICV to Wistar male rats. Lesioned animals displayed lower preference for ethanol (ETOH) than sham-operated rats. Among 6-OHDA lesioned rats only 9% became high-preferring whereas 20% of sham-operated animals became high-preferring ones. Both tropisetron (the antagonist of 5-HT3 receptors) and 8-OHDPAT (the 5-HT1A receptor agonist) reduced ETOH drinking in high-preferring rats. However, in 6-OHDA lesioned rats the effect of tropisetron was reduced although 8-OHDA retained its effect on ETOH consumption. These results suggest that brain DA neurons are involved in tropisetron action but are not responsible for antipreference effect of 8-OHDPAT.
Jankowska
E
E
Department of Pharmacology and Physiology of the Nervous System, Warszawa, Poland.
Bidzinski
A
A
Kostowski
W
W
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000428:Alcohol Drinking; D000818:Animals; D005518:Food Preferences / Q000187:drug effects; D007211:Indoles / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology; D000077526:Tropisetron
D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D016627:Oxidopamine