Relapsing bilateral uveitis and papilledema in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).
Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a non-hereditary histiocytic proliferative disorder affecting young people, with extranodal manifestations in 28-43% of cases. Eye involvement is infrequent. Lymphoproliferation in the soft tissues of the orbit and in the lids has been reported in 12% of cases but intraocular involvement is rare. We describe the case of a 12-year-old boy affected by Rosai-Dorfman disease with bilateral relapsing uveitis and papilledema that appeared four years before the onset of lymphadenopathy.
Pivetti-Pezzi
P
P
Institute of Ophthalmology, University La Sapienza, Roma, Italy.
Torce
C
C
Colabelli-Gisoldi
R A
RA
Vitale
A
A
Baccari
A
A
Pacchiarotti
A
A
D002648:Child; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D010211:Papilledema / Q000209:etiology*; D012008:Recurrence; D009418:S100 Proteins / Q000032:analysis; D014605:Uveitis / Q000209:etiology*
D009418:S100 Proteins