title: Synthesis and in vivo disposition studies of 18F-labeled HFA-134a.
abstract: A rapid synthesis of the chlorofluorocarbon replacement compound 1,1,1,2-tetrafluoroethane (HFA-134a) was identified and utilized to prepare 99+% radiochemically pure [18F]HFA-134a in 20-35% radiochemical yield. Four rats were then exposed to no-carrier-added (NCA) [18F]HFA-134a, and monitored via coincidence detection. Following withdrawal of the test atmosphere of [18F]HFA-134a, the mean half-life of [18F]HFA-134a in four rats was determined to be 7.8 +/- 1.5 min following a 10 s exposure and 8.1 +/- 1.7 minutes following a 10 min exposure.
authors.affiliation: Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Finch
authors.forename: W R
authors.initials: WR
authors.lastname: Banks
authors.forename: D R
authors.initials: DR
authors.lastname: Hwang
authors.forename: M R
authors.initials: MR
authors.lastname: Satter
authors.forename: B
authors.initials: B
authors.lastname: Ezzidene
authors.forename: J C
authors.initials: JC
authors.lastname: Mantil
authors.forename: G A
authors.initials: GA
authors.lastname: Digenis
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes; D006207:Half-Life; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D004980:Ethane / Q000031:analogs & derivatives; D005466:Fluorocarbons
chemical_list: D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; C063006:norflurane; D004980:Ethane; D005466:Fluorocarbons; C094049:apaflurane