title: Caffeine test assessment for measuring liver function in critically ill patients.
abstract: Caffeine elimination was studied in 73 patients admitted to an intensive care unit, 33 of whom had liver disease. Mean plasma clearance of caffeine in patients with no liver disease (1.30 +/- 0.79 ml/kg/min) was significantly higher than in patients with liver disease (0.39 +/- 0.23 ml/kg/min). Mean half-life of caffeine in patients with liver disease (23.96 +/- 12.19 h) was significantly higher than in patients with no liver disease (7.25 +/- 3.04 h). No significant differences in distribution volumes were found. Receptor-operator curves (ROC) for plasma clearance and the half-life of elimination of caffeine showed a high diagnostic value. Therefore, the parameters for caffeine biotransformation, i.e. Cl and t1/2, are useful for assessing liver function in the population studied.
authors.affiliation: Department of Laboratory, Lluis Alcanyis Hospital, Xativa, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Calatayud
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Alcaraz
authors.forename: P
authors.initials: P
authors.lastname: Ibáñez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001711:Biotransformation; D002110:Caffeine / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis*; D008108:Liver Diseases, Alcoholic / Q000097:blood / Q000175:diagnosis; D017114:Liver Failure, Acute / Q000097:blood / Q000175:diagnosis; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D002110:Caffeine