title: Prolonged bleeding time during ciprofloxacin therapy.
abstract: Ciprofloxacin is a broad spectum quinolone antibiotic. Side effects reported include nausea and other gastrointestinal symptoms; skin and musculoskeletal side effects may also occur. No bleeding abnormalities or alteration in coagulation have been documented. We report a case where ciprofloxacin appeared to contribute to an idiosyncratic prolongation of bleeding time although a rechallenge 8 months later did not reproduce the effect. Moreover, subsequent investigation of the influence of ciprofloxacin on bleeding parameters in 10 healthy volunteers demonstrated no alterations in bleeding parameters.
authors.affiliation: Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.
authors.forename: H L
authors.initials: HL
authors.lastname: Pilmore
authors.forename: R J
authors.initials: RJ
authors.lastname: Walker
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001760:Bleeding Time; D001792:Blood Platelets / Q000187:drug effects; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D009336:Necrosis; D009846:Oliguria / Q000473:pathology; D011693:Purpura / Q000473:pathology
chemical_list: D002939:Ciprofloxacin; D003404:Creatinine