title: Expression of insulin receptor-related receptor mRNA in the rat brain is highly restricted to forebrain cholinergic neurons.
abstract: Insulin receptor-related receptor (IRR) is a member of the insulin receptor family. However, its endogenous ligand and the physiological roles of IRR are unknown. To elucidate the physiological roles of IRR in the brain, we examined the expression of its mRNA in the rat brain by in situ hybridization. In contrast to the widespread expression of insulin receptor and insulin-like growth factor-1 receptor mRNAs in the brain, the expression of IRR mRNA was highly restricted to the forebrain cholinergic neurons. All the forebrain cholinergic neurons expressed IRR mRNA. The present findings indicate that IRR has a selective role in the brain for forebrain cholinergic function.
authors.affiliation: Department of Genetic Biochemistry, Kyoto University Faculty of Pharmaceutical Sciences, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsujimoto
authors.forename: N
authors.initials: N
authors.lastname: Tsuji
authors.forename: K
authors.initials: K
authors.lastname: Ozaki
authors.forename: M
authors.initials: M
authors.lastname: Minami
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: N
authors.initials: N
authors.lastname: Itoh
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D017403:In Situ Hybridization; D009474:Neurons / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000166:cytology / Q000378:metabolism*; D016548:Prosencephalon / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011972:Receptor, Insulin / Q000235:genetics*; D014018:Tissue Distribution
chemical_list: D012333:RNA, Messenger; D011972:Receptor, Insulin