Neutrophil-derived adhesion molecules in human digital ischaemia and reperfusion.
In order to see whether leucocyte-derived adhesion molecules are involved in ischaemia and reperfusion, the total and differential leucocyte counts and expression of the LFA complex i.e. CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1) and CD11c/CD18 (p 150,95) were monitored before and after standard cold and heat tests in 8 females with Raynaud's Disease and 8 matched controls. All patients suffered from vasoconstriction during the cold test which, compared with controls, was associated with fewer granulocytes expressing significantly more CD11b/CD18 (Mac-1) integrin and a significant degree of neutropenia persisting during reperfusion. Leucocyte-endothelial adhesive interactions may therefore occur during ischaemia and reperfusion.
Ciuffetti
G
G
II Department of Internal Medicine, University of Perugia, Italy.
Pasqualini
L
L
Fuscaldo
G
G
Piccioni
N
N
Paltriccia
R
R
Mannarino
E
E
D000328:Adult; D003080:Cold Temperature; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000276:immunology*; D007958:Leukocyte Count; D009504:Neutrophils / Q000276:immunology*; D011928:Raynaud Disease / Q000276:immunology*; D016028:Receptors, Leukocyte-Adhesion / Q000502:physiology*; D015427:Reperfusion Injury / Q000276:immunology*
D016028:Receptors, Leukocyte-Adhesion