title: [Osseointegration of titanium test bodies of different surface properties in metaphyseal bone sites of the dog--a biomechanical and histological analysis].
abstract: The alternative to the anchoring of an endoprosthesis by means of cement is the biological fixation by an ingrowth of bone into the implant surface (osseointegration). We examined the implant fixation properties of titanium experimental devices with 3 different surface structures after press-fit implantation into the bony bed of 12 dogs. One third of the 48 implants had a micro-structured surface roughened by grit-blasting, one third a roughened surface with an additional macro-groove structure (combination surface), and the remaining third a porous hydroxyapatite (HA) coating. Twelve weeks after implantation the bony ingrowth was evaluated biomechanically by measuring the force required to pull out the implant from the surrounding bone and histologically by morphometric assessment of microradiographs. In the pull-out-experiment the shearing forces were significantly lower (p < 0.01) in the devices with a roughened surface in comparison to the devices with a micro- and macro-structured surface and the HA surface. Thus, there was no significant difference between the forces required to pull out the devices with the porous HA surface and those with the combination surface. The histomorphometric assessment of bone density in the immediate vicinity of the implant and the extent of the direct contact surface of the bone implant resulted in no significant difference in all 3 groups. We did not find an interposing layer of fibrous tissue at the interface. We can demonstrate that roughening of the surface in combination with a groove structure creates a better bond between implant and bone than a roughening alone.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Klinik und Poliklinik für Orthopädie der Eberhard-Karls-Universität Tübingen.
authors.forename: C H
authors.initials: CH
authors.lastname: Hartwig
authors.forename: L
authors.initials: L
authors.lastname: Rehák
authors.forename: S
authors.initials: S
authors.lastname: Milz
authors.forename: K U
authors.initials: KU
authors.lastname: Benner
authors.forename: W
authors.initials: W
authors.lastname: Küsswetter
authors.forename: G
authors.initials: G
authors.lastname: Willmann
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000473:pathology / Q000502:physiology; D004285:Dogs; D005260:Female; D006622:Hip Prosthesis; D008297:Male; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology*; D013499:Surface Properties; D014025:Titanium
chemical_list: D014025:Titanium
vernacular_title: Das Einwachsverhalten von Titan-Prüfkörpern unterschiedlicher Oberflächenbeschaffenheit im metaphysären Knochenlager des Hundes--eine biomechanische und histologische Analyse.