The human immunoglobulin VH repertoire.
A complete map of the human immunoglobulin VH locus on chromosome 14 has recently been constructed. The locus is 1100kb in length and contains 51 functional VH segments interspersed amongst a similar number of pseudogenes. Here, Graham Cook and Ian Tomlinson review the organization of the locus, its polymorphism and the repertoire it encodes.
Cook
G P
GP
MRC Centre for Protein Engineering, Cambridge, UK.
Tomlinson
I M
IM
D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011544:Pseudogenes / Q000235:genetics
D007135:Immunoglobulin Variable Region