Ethanol's effect on tissue polyamines and ornithine decarboxylase activity: a concise review.
An extraordinarily diverse literature describes the cellular/tissue systems in which the molecular effects of both acute and chronic alcohol exposure seem to be mediated by changes in polyamine levels and/or ornithine decarboxylase (ODC) activity. The single unifying factor that links most of these studies is that they all, in some way, involve tissues that are undergoing relatively rapid cell division. Non-dividing cells expressing the NMDA receptor are a notable exception in that ethanol and the polyamines seem to act via discrete regions of that receptor. Under most cellular conditions, ODC activity is a reflection of the relative tissue polyamine content, and an increase in ODC activity and polyamine content seems to be one of the early events in the progression of quiescent cells toward cell division. Thus, it is not surprising that ethanol, which has been widely reported to delay cell division, should be found to interact with the ODC/polyamine pathway. Perhaps the most unique aspect of these studies is the fact that, with rare exception, both acute and chronic ethanol exposure have been found to slow growth and to lower tissue polyamine (putrescine) content. Furthermore, in most studies, the ethanol-induced suppression of cell division could be overcome by the administration of exogenous putrescine. These data suggest that the ethanol-induced suppression of cell division resulted from the loss of putrescine. In addition, because the cells were able to respond to the exogenous putrescine, the studies suggest that the signaling pathway remained intact beyond the polyamine synthesis step.(ABSTRACT TRUNCATED AT 250 WORDS)
Shibley
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Department of Biochemistry, East Carolina University, School of Medicine, Greenville, NC 27858, USA.
Gavigan
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MD
Pennington
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D000428:Alcohol Drinking / Q000009:adverse effects*; D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D015317:Biogenic Polyamines / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000201:enzymology; D006801:Humans; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011247:Pregnancy; D014018:Tissue Distribution
D015317:Biogenic Polyamines; D009955:Ornithine Decarboxylase