title: The mechanisms of DNA topoisomerases.
abstract: Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: J
authors.initials: J
authors.lastname: Roca
mesh_terms: D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular
chemical_list: D004247:DNA; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II