title: Endotoxin inactivating action of plasma in patients with liver cirrhosis.
abstract: The endotoxin inactivating action of plasma was evaluated in 62 patients with cirrhosis and 10 healthy subjects. Endotoxin from E. coli 0111:B4 was added to each plasma sample to a final concentration of 250 pg/ml and the percentage loss of endotoxin activity by incubation (37 degrees C for 1 h) was calculated as the endotoxin inactivating rate. The plasma endotoxin inactivating rate in cirrhotics was significantly greater than that in healthy subjects, although patients with Child C cirrhosis and marked hyperbilirubinemia had a significantly lower endotoxin inactivating rate than other cirrhotics. The plasma endotoxin inactivating rate was positively correlated to serum HDL-cholesterol levels. In patients with Child A and Child B cirrhosis, the endotoxin inactivating rate was positively correlated to the endotoxin binding capacity of plasma albumin. The present results support the assumption that the plasma of cirrhotics has a high endotoxin inactivating capacity. Its decrease may augment endotoxicity in patients with advanced liver cirrhosis.
authors.affiliation: Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fukui
authors.forename: S
authors.initials: S
authors.lastname: Tsujita
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Morimura
authors.forename: H
authors.initials: H
authors.lastname: Kitano
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: E
authors.initials: E
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Tsujii
mesh_terms: D000418:Albumins / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D004731:Endotoxins / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology
chemical_list: D000418:Albumins; D008076:Cholesterol, HDL; D004731:Endotoxins; C044101:endotoxin, Escherichia coli