Phenamide, a fungicidal metabolite from Streptomyces albospinus A19301. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
A new derivative of phenylalanine, phenamide, was discovered from the fermentation broth of an actinomycete identified as a member of the Streptomyces albospinus cluster. Phenamide was purified using successive C18 reverse phase and cation exchange chromatography. Its structure was determined by spectroscopic and chemical methods. Its molecular formula, C14H20N2O3, was determined by HRFAB-MS. Phenamide showed activity against Septoria nodorum, the causal agent of wheat glume blotch.
Makkar
N S
NS
Monsanto Agricultural Group, Unit of Monsanto Company, Chesterfield, Missouri 63198, USA.
Nickson
T E
TE
Tran
M
M
Biest
N
N
Miller-Wideman
M
M
Lawson
J
J
McGary
C I
CI
Stonard
R
R
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D000935:Antifungal Agents; C094347:phenamide; D010649:Phenylalanine