title: CRH challenge test in anxious depression.
abstract: Recently, renewed interest has developed in the concept of anxious depression. Using an operational definition of "anxious depression" based on the SADS interview, 25 patients with major depressive disorder were separated into anxious (n = 14) and nonanxious (n = 11) subtypes. These two patient groups and normal control subjects received an intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone (ACTH) and cortisol responses were compared among the three groups. Patients with anxious depression had significant attenuation of ACTH response when compared to nonanxious patients and normal control subjects.
authors.affiliation: Department of Psychiatry, University of Minnesota, Minneapolis, USA.
authors.forename: W H
authors.initials: WH
authors.lastname: Meller
authors.forename: R G
authors.initials: RG
authors.lastname: Kathol
authors.forename: S D
authors.initials: SD
authors.lastname: Samuelson
authors.forename: T L
authors.initials: TL
authors.lastname: Gehris
authors.forename: B T
authors.initials: BT
authors.lastname: Carroll
authors.forename: A F
authors.initials: AF
authors.lastname: Pitts
authors.forename: P J
authors.initials: PJ
authors.lastname: Clayton
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D001008:Anxiety Disorders / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D001143:Arousal / Q000502:physiology; D003346:Corticotropin-Releasing Hormone; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment
chemical_list: D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone