Localization and expression of osteopontin in mineralized and nonmineralized tissues of the periodontium.
To summarize results from various studies focusing on determining the expression/localization of BSP and OPN during tooth root development, there is general agreement that OPN is expressed/localized to the root surface during cementogenesis and is also seen throughout the PDL region. The expression/localization of OPN to odontoblasts and its role in dentinogenesis is less apparent. Recent studies directed at establishing odontoblast cell lines should help to resolve this conflict. Studies on BSP expression during tooth root formation indicate a very precise expression and localization of this molecule during cementogenesis indicating that this molecule may play an important role in the formation of this mineralized tissue. However, as with OPN, the expression of BSP and its role in dentin formation is not clearly defined.
MacNeil
R L
RL
Department of Periodontics/Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109-1078, USA.
Berry
J
J
D'Errico
J
J
Strayhorn
C
C
Somerman
M J
MJ
D000818:Animals; D002417:Cattle; D002448:Cell Adhesion; D003739:Dental Cementum / Q000378:metabolism*; D006801:Humans; D058574:Integrin-Binding Sialoprotein; D051379:Mice; D009805:Odontogenesis; D053495:Osteopontin; D010519:Periodontium / Q000378:metabolism*; D010750:Phosphoproteins / Q000502:physiology; D012795:Sialoglycoproteins / Q000502:physiology*; D014070:Tooth
C546871:IBSP protein, human; C546872:Ibsp protein, mouse; D058574:Integrin-Binding Sialoprotein; D010750:Phosphoproteins; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; C506896:Spp1 protein, mouse; D053495:Osteopontin