Combined effects of diltiazem and oxygen in pulmonary hypertension of mixed connective tissue disease.
A 45-year-old woman with pulmonary hypertension and mixed connective tissue disease (MCTD) underwent right heart catheterization to evaluate the effects of vasodilators. Nasal oxygen at 2 l/min in addition to 300 mg diltiazem improved pulmonary hemodynamics without adverse effects. After 1 year of diltiazem and home oxygen, sustained favorable hemodynamic effects were obtained, which were more marked than the acute effects. We conclude that this combination may be a potent treatment for pulmonary hypertension in patients with MCTD.
Shinohara
S
S
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
Murata
I
I
Yamada
H
H
Sato
T
T
Kikutani
T
T
Inoue
T
T
Ito
K
K
D000328:Adult; D003131:Combined Modality Therapy; D004110:Diltiazem / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D010102:Oxygen Inhalation Therapy
D004110:Diltiazem