Comparative in vitro activities of L-695,256, a novel carbapenem, against gram-positive bacteria.
The in vitro activity of a prototype 2-aryl carbapenem, L-695,256, against gram-positive bacteria was examined. All streptococci and oxacillin-susceptible and -resistant staphylococci were inhibited at concentrations of < or = 0.125, < or = 0.125, and 4 micrograms/ml, respectively. The activity of L-695,256 was superior to that of imipenem against other organisms intrinsically resistant to beta-lactams.
Malanoski
G
G
Department of Medicine, Deaconess Hospital, Boston, Massachusetts 02215, USA.
Collins
L
L
Eliopoulos
C T
CT
Moellering
R C
RC
Eliopoulos
G M
GM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007093:Imidazoles; C093180:L 695256