title: Metabolic evaluation of infected renal lithiasis: clinical relevance.
abstract: Complete metabolic evaluation was performed in 21 patients with infected renal lithiasis. Patients with pure struvite stones (struvite +/- carbonate apatite) were significantly less likely to have metabolic abnormalities than patients who had struvite +/- carbonate apatite+calcium oxalate (2 of 14 v 7 of 7, P = 0.0003). Urine calcium excretion was markedly higher in the mixed stone group than the pure struvite group (342 +/- 98 mg/24 h v 136 +/- 82 mg/24 h; P < 0.0001). The differing opinions among researchers regarding the likelihood of finding metabolic abnormalities in patients with urolithiasis and infection probably reflect differences in the definitions of the populations studied. If patients with calculi containing only struvite +/- carbonate apatite are evaluated, we believe that few significant metabolic abnormalities will be identified.
authors.affiliation: Methodist Hospital Institute for Kidney Stone Disease, Indianapolis, IN, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Lingeman
authors.forename: Y I
authors.initials: YI
authors.lastname: Siegel
authors.forename: B
authors.initials: B
authors.lastname: Steele
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001031:Apatites / Q000032:analysis; D002118:Calcium / Q000652:urine; D002129:Calcium Oxalate / Q000032:analysis; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications*; D017616:Magnesium Compounds / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000032:analysis; D012727:Sex Characteristics; D000069877:Struvite; D014545:Urinary Calculi / Q000737:chemistry / Q000382:microbiology* / Q000652:urine; D014556:Urine / Q000382:microbiology
chemical_list: D001031:Apatites; D017616:Magnesium Compounds; D010710:Phosphates; D002129:Calcium Oxalate; C030782:carboapatite; D000069877:Struvite; D002118:Calcium