Correlation between gold-induced enterocolitis and the presence of the HLA-DRB1*0404 allele.
OBJECTIVE
In recent years we have treated 4 rheumatoid arthritis (RA) patients who developed gold-induced enterocolitis, a well-recognized, although rare, complication of chrysotherapy. The aim of the present study was to seek any genetic predisposition for this complication.


METHODS
HLA DNA typing was done on fresh white blood cells from the 4 patients.


RESULTS
Three of the 4 patients (75%) exhibited the DRB1*0404 allele, whereas the prevalence of this allele among the Ashkenazi Jewish population of RA patients without colitis was 9.2% and 10.2% in 2 different studies.


CONCLUSIONS
The results indicate that the DRB1*0404 may be associated with risk for the development of gold-induced enterocolitis in this population and suggest that HLA DNA typing should be considered in Jews who may be undergoing chrysotherapy.
Evron
E
E
Kaplan Hospital, Rehovot, Israel.
Brautbar
C
C
Becker
S
S
Fenakel
G
G
Abend
Y
Y
Sthoeger
Z
Z
Cohen
P
P
Geltner
D
D
D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000453:epidemiology; D015984:Causality; D004247:DNA / Q000032:analysis / Q000235:genetics; D004760:Enterocolitis / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D006046:Gold / Q000009:adverse effects* / Q000627:therapeutic use; D006684:HLA-DR Antigens / Q000235:genetics* / Q000378:metabolism; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007585:Jews / Q000706:statistics & numerical data; D008875:Middle Aged; D044465:White People / Q000235:genetics
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D006046:Gold; D004247:DNA