Synthesis and in vivo disposition studies of 18F-labeled HFA-134a.
A rapid synthesis of the chlorofluorocarbon replacement compound 1,1,1,2-tetrafluoroethane (HFA-134a) was identified and utilized to prepare 99+% radiochemically pure [18F]HFA-134a in 20-35% radiochemical yield. Four rats were then exposed to no-carrier-added (NCA) [18F]HFA-134a, and monitored via coincidence detection. Following withdrawal of the test atmosphere of [18F]HFA-134a, the mean half-life of [18F]HFA-134a in four rats was determined to be 7.8 +/- 1.5 min following a 10 s exposure and 8.1 +/- 1.7 minutes following a 10 min exposure.
Finch
J R
JR
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.
Banks
W R
WR
Hwang
D R
DR
Satter
M R
MR
Ezzidene
B
B
Mantil
J C
JC
Digenis
G A
GA
D000818:Animals; D005462:Fluorine Radioisotopes; D006207:Half-Life; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D004980:Ethane / Q000031:analogs & derivatives; D005466:Fluorocarbons
D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; C063006:norflurane; D004980:Ethane; D005466:Fluorocarbons; C094049:apaflurane