Transcatheter arterial embolization as a method of cisplatin-retention enhancement on the VX2 tumor uterus transplants.
OBJECTIVE
Enhanced cisplatin (Pt) retention using transcatheter arterial chemoembolization (TAE) with Gelfoam particles was studied in rabbit uterine tumors.


METHODS
Ten rabbit uteri were inoculated with 5 x 10(7) cells of VX2 carcinoma. Three to four weeks later cisplatin, 1 mg/kg, was injected, either with (TAE group) or without (IA group) being mixed with small Gelfoam particles, into the aortic bifurcation over 5 s. Blood and tissue concentration of cisplatin were determined.


RESULTS
Slower arterial blood clearance of Pt was observed in the TAE group compared with the IA group, whereas the venous blood Pt clearance curves were similar for both groups. The uterine tumor Pt concentration at 80 min was found to be 2.52-fold higher after TAE compared with IA (p < 0.01). In the pelvic metastatic lymph nodes, the Pt concentration was 4.63 times higher after TAE than after IA (p < 0.01).


CONCLUSIONS
These data indicate that TAE is an effective means of increasing tissue concentration in uterine tumors.
Harima
K
K
Department of Radiology, Kansai Medical University, Osaka, Japan.
Harima
Y
Y
Hasegawa
T
T
Tanaka
Y
Y
D000818:Animals; D001012:Aorta, Abdominal; D002277:Carcinoma / Q000378:metabolism / Q000556:secondary / Q000628:therapy*; D002406:Catheterization, Peripheral; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage; D007668:Kidney / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D008657:Metabolic Clearance Rate; D009368:Neoplasm Transplantation; D010388:Pelvis; D011817:Rabbits; D014018:Tissue Distribution; D014594:Uterine Neoplasms / Q000378:metabolism / Q000628:therapy*; D014599:Uterus / Q000378:metabolism
D002945:Cisplatin