title: Does the mode of donor death influence the early outcome of lung transplantation? A review of lung transplantation from donors involved in major trauma.
abstract: BACKGROUND
  Pulmonary dysfunction, often delayed in presentation, is among the sequelae of major trauma. Transplantation of lungs from donors involved in major trauma therefore carries a risk of early graft dysfunction. This study was conducted to assess this risk.
  
  
  METHODS
  A retrospective comparison of the outcome from 123 donors (57 donors resulting from major trauma, group T, and 66 donors with nontraumatic origin, group NT) in 125 consecutive technically successful lung or heart-lung transplantations. Variables analyzed included the following: clinical and bacteriologic details of donors and indexes of early graft dysfunction in the recipients.
  
  
  RESULTS
  Group T donors were more likely to be younger and male (p < 0.05) and more likely to have had lung ventilation for over 48 hours (p < 0.05) than group NT donors. Microbial contamination of routine donor bronchial lavage (72 of 122, 61%) was no higher in group T (34 of 57, 60%), but, in this group, enteric gram-negative bacilli were more common (30% versus 7%; p < 0.05). Male patients were more likely to receive lungs from group T donors (35 male, 23 female), and female patients were more likely to receive lungs from group NT donors (27 male, 40 female). Mode of donor death did not affect the following indexes of early graft function: length of postoperative ventilation, ratio of arterial oxygen tension to fractional concentration of inspired oxygen at 1 or 24 hours after transplantation, or the incidence of diffuse alveolar damage in lung biopsy specimens at 7 days. Thirty-day mortality (28%) was no higher among recipients of group T lungs, but six recipient deaths were donor-related (donor-transmitted pneumonia in five and donor acquired fat embolism in one case).
  
  
  CONCLUSIONS
  The use of donors involved in major trauma does not increase the risk of early complications after lung transplantation providing their specific characteristics are recognized.
authors.affiliation: Cardiopulmonary Transplant Unit, Freeman Hospital, Newcastle-upon-Tyne, United Kingdom.
authors.forename: D A
authors.initials: DA
authors.lastname: Waller
authors.forename: A M
authors.initials: AM
authors.lastname: Thompson
authors.forename: W N
authors.initials: WN
authors.lastname: Wrightson
authors.forename: F K
authors.initials: FK
authors.lastname: Gould
authors.forename: P A
authors.initials: PA
authors.lastname: Corris
authors.forename: C J
authors.initials: CJ
authors.lastname: Hilton
authors.forename: J
authors.initials: J
authors.lastname: Forty
authors.forename: J H
authors.initials: JH
authors.lastname: Dark
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002423:Cause of Death; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D016041:Heart-Lung Transplantation / Q000401:mortality / Q000502:physiology; D006801:Humans; D008168:Lung / Q000382:microbiology; D016040:Lung Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D014947:Wounds and Injuries