title: Combined effects of diltiazem and oxygen in pulmonary hypertension of mixed connective tissue disease.
abstract: A 45-year-old woman with pulmonary hypertension and mixed connective tissue disease (MCTD) underwent right heart catheterization to evaluate the effects of vasodilators. Nasal oxygen at 2 l/min in addition to 300 mg diltiazem improved pulmonary hemodynamics without adverse effects. After 1 year of diltiazem and home oxygen, sustained favorable hemodynamic effects were obtained, which were more marked than the acute effects. We conclude that this combination may be a potent treatment for pulmonary hypertension in patients with MCTD.
authors.affiliation: Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shinohara
authors.forename: I
authors.initials: I
authors.lastname: Murata
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Kikutani
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D004110:Diltiazem / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D010102:Oxygen Inhalation Therapy
chemical_list: D004110:Diltiazem