Lectins and also bacteria modify the glycosylation of gut surface receptors in the rat.
Oral exposure to lectins or the presence or absence of bacteria in the rat small intestine were shown by histological methods using anti-lectin antibodies or digoxigenin-labelled lectins to have major effects on the state of glycosylation of lumenal membranes and cytoplasmic glycoconjugates of epithelial cells. Taken together with the dramatic effects of exposure to lectins on gut function, metabolism and bacterial ecology, this can be used as a basis for new perspectives of biomedical manipulations to improve health.
Pusztai
A
A
Rowett Research Institute, Bucksburn, Aberdeen, UK.
Ewen
S W
SW
Grant
G
G
Peumans
W J
WJ
Van Damme
E J
EJ
Coates
M E
ME
Bardocz
S
S
D000284:Administration, Oral; D000373:Agglutinins / Q000378:metabolism / Q000494:pharmacology; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000906:Antibodies; D000954:Antigens, Surface / Q000378:metabolism*; D018407:Bacterial Physiological Phenomena; D002240:Carbohydrate Sequence; D003208:Concanavalin A / Q000378:metabolism / Q000494:pharmacology; D004076:Digoxigenin; D005643:Fucose / Q000737:chemistry / Q000378:metabolism; D005856:Germ-Free Life; D006031:Glycosylation / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000187:drug effects / Q000276:immunology / Q000382:microbiology*; D007422:Intestines / Q000648:ultrastructure; D037102:Lectins / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008969:Molecular Sequence Data; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D000373:Agglutinins; D000906:Antibodies; D000954:Antigens, Surface; D037102:Lectins; D008562:Membrane Glycoproteins; D003208:Concanavalin A; D005643:Fucose; D004076:Digoxigenin