title: IgA antiphospholipid antibodies in HTLV-1-associated tropical spastic paraparesis.
abstract: A retrovirus, human T cell lymphotropic virus type 1 (HTLV-1), is an essential but not a sufficient aetiologic factor for tropical spastic paraparesis (TSP). Because some TSP patients have biological false positive tests for treponemal infections (BFP-STS), we used ELISA to study BFP-STS and anticardiolipin antibodies in 42 Jamaican TSP patients. The data indicate that in TSP anticardiolipin antibodies occur in about 26% of patients, are associated with biological false positive treponemal serology, are relatively restricted to the IgA isotype and may be induced by HTLV-1 or other nontreponemal infections.
authors.affiliation: Department of Medicine, Lousiana State University Medical Center, New Orleans 70112, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Wilson
authors.forename: C
authors.initials: C
authors.lastname: Morgan Ost
authors.forename: E N
authors.initials: EN
authors.lastname: Barton
authors.forename: M
authors.initials: M
authors.lastname: Smikle
authors.forename: B
authors.initials: B
authors.lastname: Hanchard
authors.forename: W A
authors.initials: WA
authors.lastname: Blattner
authors.forename: S
authors.initials: S
authors.lastname: Doggett
authors.forename: A E
authors.initials: AE
authors.lastname: Gharavi
mesh_terms: D000328:Adult; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000276:immunology*; D014211:Treponemal Infections / Q000175:diagnosis
chemical_list: D017152:Antibodies, Antiphospholipid; D007070:Immunoglobulin A