Effect of glucose infusion on the renal transport of purine bases and oxypurinol.
The effect of glucose infusion on renal handling of purine bases and oxypurinol was examined in 6 normal subjects. Five hundred milliliters of 1.1 M glucose solution were administered intravenously in 1 h. Fractional clearances of uric acid, xanthine and oxypurinol were significantly increased during glucose infusion, but that of hypoxanthine was not changed, while a 1-hour infusion of 500 ml of 1.1 M mannitol had no effect on the fractional clearances of purine bases and oxypurinol. These data indicate that the effect of glucose infusion on the renal clearances of uric acid, xanthine and oxypurinol was not related to osmotic diuresis but induced by glycosuria and/or hyperglycemia. Accordingly, the glycosuria- and/or hyperglycemia-induced decrease in the biological half-life of oxypurinol must be considered in the administration of allopurinol to gouty patients with uncontrolled diabetes mellitus.
Moriwaki
Y
Y
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Yamamoto
T
T
Takahashi
S
S
Suda
M
M
Higashino
K
K
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage / Q000493:pharmacokinetics; D001693:Biological Transport, Active / Q000187:drug effects; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage*; D006073:Gout / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage; D010117:Oxypurinol / Q000378:metabolism*; D011687:Purines / Q000378:metabolism*; D014527:Uric Acid / Q000378:metabolism; D019820:Xanthine; D014970:Xanthines / Q000378:metabolism
D007042:Hypoxanthines; D011687:Purines; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D008353:Mannitol; D000493:Allopurinol; D010117:Oxypurinol; D005947:Glucose