Hypouricemia, hypokalemia, proximal and distal tubular acidification defect following administration of outdated tetracycline: a case report.
A Thai female patient developed muscular weakness, hypouricemia, hypokalemia and hyperchloremic metabolic acidosis after taking outdated tetracycline. A pathophysiologic study shows a proximal tubular defect for reabsorption of urate and bicarbonate and a distal tubular acidification defect, probably caused by outdated tetracycline.
Chusil
S
S
Department of Medicine, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
Tungsanga
K
K
Wathanavaha
A
A
Pansin
P
P
D000141:Acidosis, Renal Tubular / Q000139:chemically induced*; D000328:Adult; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced*; D013752:Tetracycline / Q000009:adverse effects*; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D013752:Tetracycline