title: Hypotonic oral rehydration solution in acute diarrhoea: a controlled clinical trial.
abstract: In a controlled trial, a hypotonic oral rehydration solution (ORS) (Na+67, K+20, Cl-66, citrate 7, glucose 89 mmol/l osmolality 249 mosmol/kg) was compared with a standard WHO-ORS (Na+90, K+20, Cl-80, citrate 10, glucose 111 mmol/l, osmolality 311 mosmol/kg) in 60 children aged 5-24 months with acute watery diarrhoea. In the hypotonic ORS group, stool frequency, proportion of children who vomited, ORS requirements and purging rate over 24-48 h were reduced by 33% (p = 0.01), 30% (p = 0.02), 21% (p = 0.067) and 21% (p = 0.03), respectively. The proportion of children who vomited and the purging rate over 48 h were reduced by 23% (p = 0.03) and 10% (p = 0.097), respectively. Serum electrolytes after 48 h were comparable. The beneficial effect of hypotonic ORS was most marked in, and largely contributed by, the subgroup negative for rotavirus.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh.
authors.forename: D
authors.initials: D
authors.lastname: Mahalanabis
authors.forename: A S
authors.initials: AS
authors.lastname: Faruque
authors.forename: S S
authors.initials: SS
authors.lastname: Hoque
authors.forename: S M
authors.initials: SM
authors.lastname: Faruque
mesh_terms: D000208:Acute Disease; D001639:Bicarbonates; D002675:Child, Preschool; D003968:Diarrhea, Infantile / Q000628:therapy*; D004311:Double-Blind Method; D005440:Fluid Therapy; D005947:Glucose; D006801:Humans; D007038:Hypotonic Solutions; D007223:Infant; D011189:Potassium Chloride; D015532:Rehydration Solutions; D012965:Sodium Chloride; D013997:Time Factors
chemical_list: D001639:Bicarbonates; D007038:Hypotonic Solutions; D015532:Rehydration Solutions; C044142:World Health Organization oral rehydration solution; D012965:Sodium Chloride; D011189:Potassium Chloride; D005947:Glucose