Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study.
Groutas
W C
WC
Department of Chemistry, Wichita State University, KS 67260, USA.
Venkataraman
R
R
Chong
L S
LS
Yoder
J E
JE
Epp
J B
JB
Stanga
M A
MA
Kim
E H
EH
D056649:Cathepsin G; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D019272:Leukocyte Elastase; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053146:Myeloblastin; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000187:drug effects*; D013329:Structure-Activity Relationship
D007555:Isoxazoles; D011480:Protease Inhibitors; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; D053146:Myeloblastin