title: Human influenza virus recognition of sialyloligosaccharides.
abstract: Sialic acids are essential components of cell-surface receptors utilized by influenza viruses. To evaluate the recognition of asialic sugar parts of the receptor, three representative strains of human influenza A and B viruses were tested for their binding of a panel of sialyloligosaccharides. The highest affinity binding carbohydrate determinants recognized by the viruses in a context of different core structures were Neu5Ac alpha 2-3Gal for the type B virus, Neu5Ac alpha 2-6 Gal for the H3 subtype virus, and Neu5Ac alpha 2-6Gal beta 1-4GlcNAc for the H1 subtype virus. Penultimate to these determinants parts of the sialyloligosaccharides studied either contributed less significantly to the binding affinity, or interfered with the binding.
authors.affiliation: M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow Region.
authors.forename: A S
authors.initials: AS
authors.lastname: Gambaryan
authors.forename: V E
authors.initials: VE
authors.lastname: Piskarev
authors.forename: I A
authors.initials: IA
authors.lastname: Yamskov
authors.forename: A M
authors.initials: AM
authors.lastname: Sakharov
authors.forename: A B
authors.initials: AB
authors.lastname: Tuzikov
authors.forename: N V
authors.initials: NV
authors.lastname: Bovin
authors.forename: N E
authors.initials: NE
authors.lastname: Nifant'ev
authors.forename: M N
authors.initials: MN
authors.lastname: Matrosovich
mesh_terms: D001665:Binding Sites; D002240:Carbohydrate Sequence; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000737:chemistry / Q000378:metabolism*; D009981:Influenza B virus / Q000378:metabolism*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism*; D011991:Receptors, Virus / Q000737:chemistry / Q000378:metabolism
chemical_list: D009844:Oligosaccharides; D011991:Receptors, Virus; C016735:sialooligosaccharides