title: Factors predisposing to postoperative intraocular inflammation.
abstract: This prospective study of 123 patients undergoing cataract extraction determined the preoperative and surgical factors predisposing to an exaggerated postoperative inflammatory response. It is important to identify the patients at increased risk of complications requiring additional prophylaxis or more intensive postoperative care, particularly when selecting patients for day case surgery. Previous intraocular inflammation or surgery was the factor most strongly associated with marked inflammation on the first postoperative day (p < 0.01, compared to uncomplicated patients). As a result, patients stayed in hospital an average of one day longer (p < 0.001) and required significantly more steroid drops (p < 0.001). Other factors of significance, but reducing importance were: difficult surgery, non-caucasian race and brown irides. Amongst uncomplicated patients, the difficulty of surgery was most significantly related to a high inflammation score (p < 0.01). Non-caucasian patients stayed in hospital significantly longer than their caucasian counterparts (p < 0.05), and required more steroid drops (p < 0.001). Of caucasian patients, those with brown irides were inpatients for significantly longer than those with blue or hazel (p < 0.05). No other factors studied significantly altered postoperative inflammation: neither the presence of diabetes, nor the technique of cataract extraction.
authors.affiliation: Department of Ophthalmology, Greenwich District Hospital, London, U.K.
authors.forename: M C
authors.initials: MC
authors.lastname: Corbett
authors.forename: M
authors.initials: M
authors.lastname: Hingorani
authors.forename: J E
authors.initials: JE
authors.lastname: Boulton
authors.forename: J S
authors.initials: JS
authors.lastname: Shilling
mesh_terms: D000368:Aged; D002387:Cataract Extraction / Q000009:adverse effects*; D015984:Causality; D048909:Diabetes Complications; D009877:Endophthalmitis / Q000453:epidemiology*; D005127:Eye Color; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D007902:Length of Stay; D008131:London / Q000453:epidemiology; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology*; D011446:Prospective Studies; D044469:Racial Groups