Incidence of penile pain after injection of a new formulation of prostaglandin E1.
OBJECTIVE
We determined the incidence of pain with injection of a new formulation of prostaglandin E1.


METHODS
A total of 63 subjects with erectile dysfunction underwent treatment with the new formulation of prostaglandin E1. Evidence of pain associated with injection was obtained by questionnaire and through questioning.


RESULTS
A total of 451 injections was given to 63 subjects in the office, with 16 episodes (3.5%) of pain in 10 (15.9%). Then, 680 injections were performed by 38 subjects at home, with 15 episodes (2.2%) of pain in 8 (21%). Pain was not dose related.


CONCLUSIONS
The new formulation of prostaglandin E1 is less likely to be associated with pain compared with alcohol based formulations.
Chen
J
J
Division of Geriatric Medicine, Medical College of Virginia, Richmond, USA.
Godschalk
M F
MF
Katz
P G
PG
Mulligan
T
T
D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D000553:Ambulatory Care; D002626:Chemistry, Pharmaceutical; D007172:Erectile Dysfunction / Q000188:drug therapy*; D000431:Ethanol; D006801:Humans; D007267:Injections / Q000009:adverse effects; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced*; D010413:Penis; D012648:Self Care; D012678:Sensation Disorders / Q000139:chemically induced; D014867:Water
D014867:Water; D000431:Ethanol; D000527:Alprostadil