[The limitation of glucose catabolism as a factor in protection during hypoxia].
Violuric acid was first shown to have antihypoxic and antioxidative properties, to exert protective action in sodium nitrite-induced hemic hypoxia. Hepatic glucose and glucogen levels increased, the activity of glucose-6- phosphodihydrogenase enhanced, while that of lactate dehydrogenase and alkaline phosphatase decreased, the content of cAMP restored, whereas cGMP and 2,3-diphosphoglycerate levels decreased to a greater extent. The action of violuric acid was especially evident at the ultrastructural level-the ultrastructure of brush receptor elements in anoxia in the presence of violuric acid's action retained all the features characteristic for intact animals, which was accompanied by a significant accumulation of glycogen in the neuroplasm.
Burbello
A T
AT
Vishvtseva
V V
VV
Denisenko
P P
PP
Safonova
A F
AF
Dobrokhotova
E G
EG
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001463:Barbiturates / Q000627:therapeutic use; D050260:Carbohydrate Metabolism; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000378:metabolism*; D000860:Hypoxia / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D012977:Sodium Nitrite
D000975:Antioxidants; D001463:Barbiturates; C094277:violuric acid; D005947:Glucose; D012977:Sodium Nitrite
Ogranichenie katabolizma gliukozy kak faktor zashchity pri gipoksii.