Morphometric studies of acute renal failure using anti-brush-border and other antisera.
Correlations have been shown between renal excretory function and the extent of immunohistological staining in the kidney of proximal tubular brush border and Tamm-Horsfall protein. These findings confirm the importance of the integrity of the proximal tubule in control of the glomerular filtration rate and also show that the thick limb of the loop of Henle is damaged, as well as the proximal tubule, in renal failure.
Howie
A J
AJ
University of Birmingham, Department of Pathology, Medical School, UK.
D058186:Acute Kidney Injury / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D000906:Antibodies; D006801:Humans; D007150:Immunohistochemistry; D007687:Kidney Tubules, Proximal / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D008871:Microvilli / Q000276:immunology; D009088:Mucoproteins / Q000276:immunology; D058949:Uromodulin
D000906:Antibodies; D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin