title: Indium-111-DTPA-octreotide scintigraphy modulation by treatment with unlabelled somatostatin analogue in small-cell lung cancer.
abstract: OBJECTIVE
  Small-cell lung cancer (SCLC) tissue expresses somatostatin receptors and can be visualized by means of the indium-111-labelled somatostatin analogue DTPA-D-Pheoctreotide. The aim of the study was to investigate whether treatment with a cold somatostatin analogue can affect the imaging of somatostatin receptor scintigraphy.
  
  
  METHODS
  Three patients with SCLC were treated with 200 micrograms of cold octreotide three times a day subcutaneously for 7 days. Whole body and planar scintigraphy was performed before and after the treatment.
  
  
  RESULTS
  111In-DTPA-octreotide uptake was increased in cancer lesions, whereas fixation in normal tissues (liver, spleen, kidneys) decreased.
  
  
  CONCLUSIONS
  This is the first demonstration of an enhancement of SCLC imaging following unlabelled somatostatin analogue administration. Similar results have been described by other authors in a limited number of carcinoid tumors.
authors.affiliation: Department of Pneumology, Ospedale Niguarda, Milano, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Soresi
authors.forename: E
authors.initials: E
authors.lastname: Bombardieri
authors.forename: A
authors.initials: A
authors.lastname: Chiti
authors.forename: R
authors.initials: R
authors.lastname: Boffi
authors.forename: G
authors.initials: G
authors.lastname: Invernizzi
authors.forename: F
authors.initials: F
authors.lastname: Crippa
authors.forename: L
authors.initials: L
authors.lastname: Maffioli
mesh_terms: D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007205:Indium Radioisotopes; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D015282:Octreotide / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000378:metabolism; D015203:Reproducibility of Results
chemical_list: D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; C071632:SDZ 215-811; D004369:Pentetic Acid; D015282:Octreotide