[Dapiprazol antagonizes tropicamide- and phenylephrine-induced mydriasis in the elderly].
Dapiprazole eye drops were applied 1 h after topical tropicamide or phenylephrine instillation in 30 elderly subjects. Pupil diameter normalized much earlier than in controls receiving placebo. Dapiprazole constricted the tropicamide-dilated pupil by 1 mm after 1 h and normalized the pupil diameter of the phenylephrine-dilated pupil within 1 h, whereas the pupils of the patients receiving placebo remained dilated. Intraocular pressure did not change; no major side effects were seen.
Warlich
M
M
Augenklinik mit Poliklinik und Lehranstalt für Orthoptisten, Universität des Saarlandes, Homburg.
Weik
R
R
Höh
H
H
Ruprecht
K W
KW
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015878:Mydriasis / Q000139:chemically induced* / Q000188:drug therapy; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010879:Piperazines; D011446:Prospective Studies; D012025:Reflex, Pupillary / Q000187:drug effects*; D014230:Triazoles / Q000494:pharmacology*; D014331:Tropicamide / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D009883:Ophthalmic Solutions; D010879:Piperazines; D014230:Triazoles; D010656:Phenylephrine; C035289:dapiprazole; D014331:Tropicamide
Dapiprazol antagonisiert die Tropicamid- und die Phenylephrin-induzierte Mydriasis bei älteren Personen.