Fate of dimethylamine in rat and mouse.
1. [U-14C]-dimethylamine hydrochloride was administered by gavage (20 mumol/kg body weight) to adult male Wistar rat and CD1 strain mouse. 2. In both species, urine was the main route of excretion with the majority of radiolabel (91%) being voided during the first day. Additional small amounts of radioactivity were detected in the 24-72 h urine (2%), in faeces (2%) and amidst exhaled air (1%), with minor amounts remaining within the carcass (1%) after 3 days. 3. Metabolism was limited to demethylation, with the majority of the compound (89% dose; 96% urinary radioactivity) being excreted unchanged.
Zhang
A Q
AQ
Department of Pharmacology and Toxicology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
Mitchell
S C
SC
Smith
R L
RL
D000818:Animals; D004123:Dimethylamines / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D005243:Feces / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D008745:Methylation; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D004123:Dimethylamines; C034516:dimethylamine