Does early growth delay occur in diabetic pregnancy?
OBJECTIVE
To identify the date of ovulation in pregnant women with Type 1 diabetes in order to assess the validity of the concept of early growth delay.


METHODS
Identification of ovulation by measurement of urinary luteinising hormone and assessment of fetal growth using ultrasound scan.


METHODS
Diabetic pre-pregnancy and antenatal clinic in a teaching hospital.


METHODS
Twenty women with Type 1 diabetes who had attended a pre-pregnancy clinic.


METHODS
Urinary LH, by laboratory and kit methods, during conception cycles. Human chorionic gonadotrophin measured in early pregnancy. Early ultrasound scans by a single observer blind to menstrual and ovulation dates.


RESULTS
Gestation calculated from ovulation date and gestation estimated from menstrual dates, compared with gestation at age indicated by early ultrasound scan.


RESULTS
When the date of ovulation was identified in 20 women with Type 1 diabetes there was no evidence of growth delay in any pregnancy. When gestation was estimated from menstrual dates there was apparent early growth delay in six pregnancies.


CONCLUSIONS
This study, together with others discussed, indicates that early growth delay is probably an artefact of incorrectly estimated ovulation date.
Steel
J M
JM
Department of Diabetes, Royal Infirmary Edinburgh.
Wu
P S
PS
Johnstone
F D
FD
Muir
B B
BB
Sweeting
V M
VM
Hillier
S G
SG
D003922:Diabetes Mellitus, Type 1; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine; D010061:Ovulation Detection; D016742:Preconception Care; D011247:Pregnancy; D011254:Pregnancy in Diabetics
D007986:Luteinizing Hormone