[Experimental models of arterial thrombosis].
Arterial thrombosis is clearly responsible for a very wide range of cardiovascular diseases, which is why many models of arterial thrombosis have been developed. These models are based on various techniques such as electrical, mechanical, biochemical, photochemical induction. They are an essential prerequisite to the understanding of molecular and cellular phenomena and are also essential to test the antithrombotic activity of new molecules before the first clinical trials in man. The large range of models means that the most appropriate model can be selected for the study of the test substance. However, the antithrombotic activity of a substance needs to be studied by several models. Most of these models induce total occlusion in which the number of parameters studied is limited. As a result of technological progress and the development of techniques such as laser and image analysers, new perspectives are now available for both basic and pharmacological research. Consequently, the already major value for these models should continue to grow over the years to come.
Aguejouf
O
O
Laboratoire d'Hématologie, Faculté de Pharmacie de Bordeaux II.
Imbault
P
P
Jourdan
A
A
Doutremepuich
F
F
Juaneda
M
M
Doutremepuich
C
C
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D008866:Microsurgery; D013927:Thrombosis / Q000601:surgery*
D005343:Fibrinolytic Agents
Modèles expérimentaux de thrombose artérielle.