title: Vanadium: a modifier of drug-metabolizing enzyme patterns and its critical role in cellular proliferation in transplantable murine lymphoma.
abstract: Vanadium, as ammonium monovanadate, has been found to stimulate tumour cell proliferation in mice bearing a transplantable ascitic lymphoma. Markers including microsomal cytochrome P-450, UDP-glucuronyltransferase and cytosolic glutathione-S-transferase showed substantial alterations in a dose-responsive manner with vanadium administration when compared to the controls. Stimulation of tumour progression is also reflected by increased tumour cell count and decreased survival of the host.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: A
authors.initials: A
authors.lastname: Chakraborty
authors.forename: R
authors.initials: R
authors.lastname: Ghosh
authors.forename: K
authors.initials: K
authors.lastname: Roy
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: P
authors.initials: P
authors.lastname: Chowdhury
authors.forename: M
authors.initials: M
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005982:Glutathione Transferase / Q000378:metabolism*; D008223:Lymphoma / Q000201:enzymology; D051379:Mice; D013997:Time Factors; D014639:Vanadium / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014639:Vanadium; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase