[CoQ10 blood levels and erythrocyte concentration of GSH in ischemic heart patients during exercise test (effects of vitamin E)].
During exercise there is an increase of oxygen consumption with production of superoxide anion. Tocopherols and ubiquinones are intrinsic lipid components involved in antioxidant protection and also glutathione reduced is an important water soluble antioxidant. The authors take into consideration 28 patients with ischemic heart disease coming in a rehabilitation center. In a group of 14 of them we studied the effects on the exercise ergonometer test of administration of 1200 mg of tocopherol on the behaviour of ubiquinone plasmatic levels and GSH. In this group CoQ10 after exercise increase significantly (0.762 SD 0.134 g/ml before vs 0.827 SD 0.89 after). GSH doesn't increase after (2.5 SD 0.459 mM/l vs 2.492 SD 0.457). In the group of patients without tocopherol after exercise CoQ10 decrease significantly (-39%) and also GSH has the same behaviour (-15%). Our study shows that the administration of tocopherol prevents lipoperoxidation occurring during exercise test.
Fontana
L
L
Centro di Riabilitazione Cardiologica, Ospedale San Martino, Genova.
Rossi
M A
MA
Baccelliere
L
L
Papagna
D
D
Cottalasso
D
D
D000328:Adult; D000368:Aged; D005080:Exercise Test; D005609:Free Radicals / Q000378:metabolism; D005978:Glutathione / Q000097:blood*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000378:metabolism / Q000534:rehabilitation; D010101:Oxygen Consumption; D014451:Ubiquinone / Q000097:blood*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D005609:Free Radicals; D014451:Ubiquinone; D014810:Vitamin E; D005978:Glutathione
Comportamento della concentrazione plasmatica di CoQ10 ed eritrocitaria di GSH in cardiopatici ischemici sottoposti a test ergometrico (effetti indotti dall'assunzione di vitamina E).