title: Preconditioning stimuli and inadvertent preconditioning.
abstract: There are several factors besides brief episodes of total coronary occlusion which can provide sufficient stress to result in a preconditioning-like effect on the size of a myocardial infarction. Partial coronary artery stenosis, hypoxia, stretch, catecholamines, rapid pacing, and certain pharmacologic therapies may provide preconditioning stimuli. These same factors as well as mechanical complications in which a coronary artery is briefly occluded or stenosed prior to a subsequent coronary occlusion may lead to inadvertent preconditioning and confound the results of experimental cardiology studies.
authors.forename: R A
authors.initials: RA
authors.lastname: Kloner
authors.forename: K
authors.initials: K
authors.lastname: Przyklenk
authors.forename: P
authors.initials: P
authors.lastname: Whittaker
authors.forename: S
authors.initials: S
authors.lastname: Hale
mesh_terms: D003327:Coronary Disease / Q000209:etiology*; D006801:Humans; D013312:Stress, Physiological / Q000150:complications