The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5.
The human beta crystallin genes CRYBB2, CRYBB2P1, CRYBB3, and CRYBA4 are located in 22q11.2. Using interspecific backcross analysis, we mapped the mouse homologues of CRYBB2, CRYBB3, and CRYBA4 (i.e., Crybb2, Crybb3, and Cryba4) to the central region of mouse chromosome 5. The homologue of human CRYBB2P1 is absent in mouse. These assignments define a new region of homology in human and mouse.
Hulsebos
T J
TJ
Institute of Human Genetics, University of Amsterdam, The Netherlands.
Jenkins
N A
NA
Gilbert
D J
DJ
Copeland
N G
NG
D000818:Animals; D002386:Cataract / Q000235:genetics; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D003433:Crosses, Genetic; D003459:Crystallins / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D006824:Hybridization, Genetic; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D009115:Muridae / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D003459:Crystallins; D005819:Genetic Markers