title: Is there a role for in vivo methylene blue staining in the prediction of bladder tumour recurrence?
abstract: OBJECTIVE
  To assess the role of in vivo staining with intravesical methylene blue in predicting tumour recurrence.
  
  
  METHODS
  Thirty-nine patients (27 men and 12 women, age range 43-75 years) newly diagnosed with bladder tumours were prospectively studied and followed for a minimum of 2 years. Potential biopsy sites were identified by staining intravesically with a 1% methylene blue solution and compared with random biopsy sites.
  
  
  RESULTS
  Biopsy directed by methylene blue staining detected carcinoma in situ more often than random biopsy. Rates of recurrence were similar in both stained and unstained groups.
  
  
  CONCLUSIONS
  Methylene blue staining does not add significantly to the management of patients presenting with bladder tumours.
authors.affiliation: Meath Hospital, Dublin, Ireland.
authors.forename: T A
authors.initials: TA
authors.lastname: Creagh
authors.forename: M
authors.initials: M
authors.lastname: Gleeson
authors.forename: D
authors.initials: D
authors.lastname: Travis
authors.forename: R
authors.initials: R
authors.lastname: Grainger
authors.forename: T E
authors.initials: TE
authors.lastname: McDermott
authors.forename: M R
authors.initials: MR
authors.lastname: Butler
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002278:Carcinoma in Situ / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008751:Methylene Blue; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011446:Prospective Studies; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*
chemical_list: D008751:Methylene Blue