title: [Effects of lumbar peridural anesthesia on tissue pO2 of the large intestine in man].
abstract: OBJECTIVE
  The aim of this study was to investigate the effect of 15 ml bupivacaine 0.25%, given via an epidural catheter, on the tissue-PO2 of the colon wall in humans.
  
  
  METHODS
  Nine patients were studied during elective colorectal surgery. The tissue-PO2 was measured by polarography, using a multiwire surface probe.
  
  
  RESULTS
  There was no significant change in cardiac index and arterial oxygen delivery after the injection of bupivacaine. At the serosal side of the colon wall the tissue-PO2 increased from 34 to 51 mmHg after epidural bupivacaine, which is statistically significant. Spinal nerve block produces sympathetic denervation of the bowel with an increase of regional nutritive blood flow.
  
  
  CONCLUSIONS
  It is concluded that epidural bupivacaine has a favourable effect on tissue oxygenation of the colon during colorectal surgery.
authors.affiliation: Abteilung für Anästhesiologie und Operative Intensivmedizin, Klinikum der Justus-Liebig-Universität Giessen.
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Schück
authors.forename: U
authors.initials: U
authors.lastname: Erkens
authors.forename: J
authors.initials: J
authors.lastname: Sticher
authors.forename: C
authors.initials: C
authors.lastname: Haase
authors.forename: G
authors.initials: G
authors.lastname: Hempelmann
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural; D002045:Bupivacaine; D003106:Colon / Q000098:blood supply*; D015179:Colorectal Neoplasms / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects
chemical_list: D002045:Bupivacaine
vernacular_title: Einflüsse der lumbalen Periduralanästhesie auf den Gewebe-PO2 des Dickdarms beim Menschen.