[DNA ploidy of tumor cells in prognostication of the course of malignant neoformations].
DNA flow cytometry (FCM) was used for the clinical prognosis in patients undergone surgical removal of a tumor. The relationship between the structure of the tumor cell population (ploidy) and the frequency, time of a relapse onset (recurrence, metastasis), and the survival length were analyzed. All the patients had presurgical treatment (chemo- and/or radiotherapy). The patients were followed up for 5 to 9 years after surgery. The groups under study included 177 cases of breast cancer, 81 cases of larynx cancer, and 62 cases of colon cancer. Among the patients, the onset of a relapse was earlier and occurred more frequently in cases of aneuploid tumors among the patients regardless of the tumor type. In patients with aneuploid tumors, the most unfavorable prognosis was inherent in the hyperdiploid and multiclonal ones. The probability of 5-year survival for patients with aneuploid tumors appeared to be 20-30% lower than that in cases of diploid ones.
Dobrynin
Ia V
IaV
Nikolaeva
T G
TG
Letiagin
V P
VP
Alferov
V S
VS
Prorokov
V V
VV
D000782:Aneuploidy; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D003110:Colonic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D004273:DNA, Neoplasm / Q000235:genetics*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011336:Probability; D011379:Prognosis; D012984:Software; D013997:Time Factors
D004273:DNA, Neoplasm
Ploidnost' DNK opukholevykh kletok v prognozirovanii techeniia zlokachestvennykh novoobrazovaniĭ.