title: Conservation of the T-box gene family from Mus musculus to Caenorhabditis elegans.
abstract: Recently, a novel family of genes with a region of homology to the mouse T locus, which is known to play a crucial, and conserved, role in vertebrate development, has been discovered. The region of homology has been named the T-box. The T-box domain of the prototypical T locus product is associated with sequence-specific DNA binding activity. In this report, we have characterized four members of the T-box gene family from the nematode Caenorhabditis elegans. All lie in close proximity to each other in the middle of chromosome III. Homology analysis among all completely sequenced T-box products indicates a larger size for the conserved T-box domain (166 to 203 residues) than previously reported. Phylogenetic analysis suggests that one C. elegans T-box gene may be a direct ortholog of the mouse Tbx2 and Drosophila omb genes. The accumulated data demonstrate the ancient nature of the T-box gene family and suggest the existence of at least three separate T-box-containing genes in a common early metazoan ancestor to nematodes and vertebrates.
authors.affiliation: Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.
authors.forename: S I
authors.initials: SI
authors.lastname: Agulnik
authors.forename: R J
authors.initials: RJ
authors.lastname: Bollag
authors.forename: L M
authors.initials: LM
authors.lastname: Silver
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000235:genetics*; D003001:Cloning, Molecular; D017124:Conserved Sequence; D018076:DNA, Complementary; D016208:Databases, Factual; D004331:Drosophila melanogaster / Q000235:genetics; D015723:Gene Library; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014982:Xenopus laevis / Q000235:genetics; D015027:Zebrafish / Q000235:genetics
chemical_list: D018076:DNA, Complementary