title: [The steroid content of the amniotic fluid in the 1st and 2nd pregnancy trimesters in 21-hydroxylase insufficiency and in fetal central nervous system defects].
abstract: A total of 103 samples of amniotic fluid obtained by transabdominal amniocentesis were examined, 52 of these from women at a high risk of giving birth to children with congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency and 30 ones with fetuses with different neural tube malformations. 17-Hydroxyprogesterone was found to be a reliable marker indicating the disease in fetuses from the group at risk of hereditary 21-OH deficiency. This marker can be effectively used as early as in the 1 gestation trimester. Fetal CNS defects are associated with hypofunction of the adrenal cortex in the II gestation trimester, observed in 60-63% of cases with hydrocephalus, anencephaly, or microcephaly. Since the function of fetal adrenals is of paramount importance for the development and maturation of a fetus, it should be examined in case of developmental defects of the neural tube, in order to predict the effect of prenatal treatment.
authors.forename: I G
authors.initials: IG
authors.lastname: Dzenis
authors.forename: E K
authors.initials: EK
authors.lastname: Brykova
authors.forename: N V
authors.initials: NV
authors.lastname: Zaretskaia
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Polesterov
authors.forename: V A
authors.initials: VA
authors.lastname: Bakharev
authors.forename: N D
authors.initials: ND
authors.lastname: Fanchenko
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000312:Adrenal Hyperplasia, Congenital / Q000378:metabolism; D000653:Amniotic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D002490:Central Nervous System / Q000002:abnormalities*; D005260:Female; D005315:Fetal Diseases / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D006908:Hydroxyprogesterones / Q000032:analysis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D006908:Hydroxyprogesterones; D019326:17-alpha-Hydroxyprogesterone; D006854:Hydrocortisone
vernacular_title: Soderzhanie steroidov v amnioticheskoĭ zhidkosti v I i II trimestrakh beremennosti pri nedostatochnosti 21-gidroksilazy i porokakh tsentral'noĭ nervnoĭ sistema ploda.