Interference of MIBG uptake by medication: a case report.
Phaeochromocytoma is one of the causes of hypertension. Topographic diagnosis is made by CT-scans or scanning with 123I- or 131I-metaiodobenzylguanidine (123I- or 131I-MIBG). We describe a patient with recurrent episodes of severe hypertension and increased serum catecholamines. With the suspicion of a phaeochromocytoma labetalol was given. Subsequently the 123I-MIBG scan showed an abnormal distribution of MIBG. After discontinuation of labetalol therapy the biodistribution of 123I-MIBG returned to normal. A list of drugs known and one drug which may be expected to interfere with MIBG scintigraphy are appended. It seems advisable to discontinue labetalol and other medication that may interfere with MIBG for at least several days before administering MIBG.
Apeldoorn
L
L
Department of Internal Medicine, Ziekenhuis Amstelveen, Netherlands.
Voerman
H J
HJ
Hoefnagel
C A
CA
D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000378:metabolism*; D003937:Diagnosis, Differential; D004347:Drug Interactions; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000378:metabolism*; D007741:Labetalol / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging
D003287:Contrast Media; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine; D007741:Labetalol