title: A specific protein found in human senescent fibroblasts.
abstract: The limited potential for proliferation of human fibroblasts in culture represents cell level senescence. Aging is a programmed process under genetic control, and at certain stage of the life-span of animal cells, some genes start to express. Studying the biomarkers of senescent cells is important to understanding the basic mechanism of aging which may be relevant to the normal cell growth control and tumor biology. A protein with 72,000 Dalton molecular weight was detected by the hybridoma method in our laboratory. The protein shows specificity to senescent or presenescent cells of several cell lines, including WI-38, K.D., U2OS, etc.
authors.affiliation: Department of Orthopedics, Second Affiliated Hospital, Fourth Military Medical University, Xi'an.
authors.forename: Q
authors.initials: Q
authors.lastname: Fan
authors.forename: H V
authors.initials: HV
authors.lastname: Frankel
authors.forename: D
authors.initials: D
authors.lastname: Present
authors.forename: B
authors.initials: B
authors.lastname: Winchester
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D015415:Biomarkers / Q000032:analysis; D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology; D002478:Cells, Cultured; D016922:Cellular Senescence; D005260:Female; D005347:Fibroblasts / Q000737:chemistry* / Q000166:cytology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D012516:Osteosarcoma / Q000737:chemistry / Q000473:pathology; D011506:Proteins / Q000032:analysis*
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D011506:Proteins