title: Biotransformation of diphenyl ether by the yeast Trichosporon beigelii SBUG 752.
abstract: Trichosporon beigelii SBUG 752 was able to transform diphenyl ether. By TLC, HPLC, GC, GC-MS, NMR- and UV-spectroscopy, several oxidation products were identified. The primary attack was initiated by a monooxygenation step, resulting in the formation of 4-hydroxydiphenyl ether, 2-hydroxydiphenyl ether and 3-hydroxydiphenyl ether (48:47:5). Further oxidation led to 3,4-dihydroxydiphenyl ether. As a characteristic product resulting from the cleavage of an aromatic ring, the lactone of 2-hydroxy-4-phenoxymuconic acid was identified. The possible mechanism of ring cleavage to yield this metabolite is discussed.
authors.affiliation: Institut f. Mikrobiologie, Ernst-Moritz-Arndt-Universität, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Schauer
authors.forename: K
authors.initials: K
authors.lastname: Henning
authors.forename: H
authors.initials: H
authors.lastname: Pscheidl
authors.forename: R M
authors.initials: RM
authors.lastname: Wittich
authors.forename: P
authors.initials: P
authors.lastname: Fortnagel
authors.forename: H
authors.initials: H
authors.lastname: Wilkes
authors.forename: V
authors.initials: V
authors.lastname: Sinnwell
authors.forename: W
authors.initials: W
authors.lastname: Francke
mesh_terms: D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004147:Dioxins / Q000633:toxicity; D004787:Environmental Pollution; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010647:Phenyl Ethers / Q000737:chemistry / Q000378:metabolism*; D014250:Trichosporon / Q000378:metabolism*; D014866:Waste Products
chemical_list: D004147:Dioxins; D010647:Phenyl Ethers; D014866:Waste Products; C031538:phenyl ether