title: Fluid changes during pregnancy: use of bioimpedance spectroscopy.
abstract: The increase in body water during pregnancy is responsible for the largest portion of weight gain and is of interest of clinical practitioners. However, assessing changes in body fluids is not easily accomplished during pregnancy. The purpose of this study was to examine the accuracy of bioelectrical impedance spectroscopy for estimating fluid volumes before, during, and after pregnancy. Ten healthy adult women were recruited for the study. Total body water (TBW) and extracellular fluid (ECF) volume were measured at baseline (preconception); 8-10, 24-26, and 34-36 wk of gestation; and 4-6 wk postpartum by deuterium oxide and NaBr dilution, respectively. Estimates of TBW and ECF were also obtained by bioimpedance spectroscopy (BIS). At baseline, mean values for dilution and BIS estimates of TBW and ECF were 33.2 +/- 4.6 (SD) vs. 31.6 +/- 6.2 liters and 15.2 +/- 1.3 vs. 16.9 +/- 2.3 liters, respectively. TBW and ECF estimated by BIS were not significantly different from the dilution values at any time point. These results suggest that BIS may be useful in estimating volumes of ECF and TBW during pregnancy.
authors.affiliation: United States Department of Agriculture, Western Human Nutrition Research Center, Presidio of San Francisco, California, 94129, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Van Loan
authors.forename: L E
authors.initials: LE
authors.lastname: Kopp
authors.forename: J C
authors.initials: JC
authors.lastname: King
authors.forename: W W
authors.initials: WW
authors.lastname: Wong
authors.forename: P L
authors.initials: PL
authors.lastname: Mayclin
mesh_terms: D000328:Adult; D001834:Body Water / Q000378:metabolism*; D017666:Deuterium Oxide; D017097:Electric Impedance; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D006801:Humans; D007201:Indicator Dilution Techniques; D008954:Models, Biological; D011247:Pregnancy / Q000378:metabolism*
chemical_list: D017666:Deuterium Oxide