title: Trends in survival after childhood cancer in Denmark, 1943-87: a population-based study.
abstract: Survival from cancer in childhood and adolescence was studied in a population-based series of 8312 cases in children aged 0-19 years notified to the Danish Cancer Registry during 1943-87. During the first period (1943-72), 5-year survival rates from all malignant neoplasms increased from 23% (1943-52) to 33% (1963-72). The greatest improvement was seen during the period 1973-87 when 5-year survival rates reached 64% (1983-87). Between 1973-77 and 1983-87, 5-year survival rates increased from 32% to 62% for leukaemia, from 40% to 70% for acute lymphoblastic leukaemia, from 35% to 54% for non-Hodgkin's lymphoma, from 50% to 66% for central nervous system neoplasms and from 25% to 49% for bone tumours. An improvement in 5-year survival rates from Wilms' tumour was seen between 1960 (19%) and 1980 (81%). Up to 1972, the 5-year survival rate from germ-cell neoplasms was approximately 40%; among patients diagnosed in 1983-87, 76% survived for 5-years. Annual lethality decreased by 2.5% for all malignant neoplasms in 1943-72 and by 4.4% in 1972-87. Lethality was similar for boys and girls during the period 1943-72, but was significantly lower for girls subsequently. A marked effect of age at diagnosis was seen in the early registration period, where lethality rate for the age group 0-9 years was substantially higher compared with that in the age group 10-19 years. This inequality persisted only for children less than 2 years of age at the time of diagnosis in the later period.
authors.affiliation: Danish Cancer Society, Division for Cancer Epidemiology, Rigshospitalet, Copenhagen.
authors.forename: P
authors.initials: P
authors.lastname: de Nully Brown
authors.forename: J H
authors.initials: JH
authors.lastname: Olsen
authors.forename: H
authors.initials: H
authors.lastname: Hertz
authors.forename: B
authors.initials: B
authors.lastname: Carstensen
authors.forename: A
authors.initials: A
authors.lastname: Bautz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001859:Bone Neoplasms / Q000401:mortality; D016543:Central Nervous System Neoplasms / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D003718:Denmark; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000401:mortality; D007938:Leukemia / Q000401:mortality; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality; D008297:Male; D015233:Models, Statistical; D009369:Neoplasms / Q000401:mortality*; D009373:Neoplasms, Germ Cell and Embryonal / Q000401:mortality; D012042:Registries; D012737:Sex Factors; D016019:Survival Analysis; D015996:Survival Rate; D009396:Wilms Tumor / Q000401:mortality