title: Omeprazole and dry mouth.
abstract: BACKGROUND
  Omeprazole causes irreversible inhibition of the hydrogen/potassium adenosine triphosphatase enzyme, leading to a marked reduction in both acid secretion and volume of gastric juice. Reported side-effects include nausea, vomiting, diarrhoea, constipation, and headache. We report the development of dry mouth during omeprazole therapy.
  
  
  METHODS
  We have identified six patients taking omeprazole for more than 6 weeks who complained of a dry mouth. Salivary production was measured as whole salivary flow produced over a 10-min period spat into a collecting vessel and as 5% citric acid-stimulated parotid salivary flow collected with a Lashley cup device placed over the parotid duct. Flow rates were evaluated both during and after cessation of treatment. Saliva produced was then cultured for microbes.
  
  
  RESULTS
  Four of the six had subnormal parotid or whole salivary flow rates on treatment that recovered after stopping treatment. The increase after treatment was marked in four. Significant amounts of Candida albicans grew from the saliva of the three patients with the lowest salivary flows; one saliva also grew Staphylococcus aureus.
  
  
  CONCLUSIONS
  Salivary flow is reduced in some patients treated with omeprazole, returning to normal after cessation of treatment. This reduction may predispose to opportunistic infection, particularly in the edentulous.
authors.affiliation: Gastrointestinal Laboratory, Rayne Institute, St Thomas' Hospital, London, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Teare
authors.forename: C
authors.initials: C
authors.lastname: Spedding
authors.forename: M W
authors.initials: MW
authors.lastname: Whitehead
authors.forename: S M
authors.initials: SM
authors.lastname: Greenfield
authors.forename: S J
authors.initials: SJ
authors.lastname: Challacombe
authors.forename: R P
authors.initials: RP
authors.lastname: Thompson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002176:Candida albicans / Q000302:isolation & purification; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects* / Q000627:therapeutic use; D012463:Saliva / Q000737:chemistry / Q000382:microbiology; D012472:Salivation / Q000187:drug effects; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013997:Time Factors; D014987:Xerostomia / Q000139:chemically induced*
chemical_list: D009853:Omeprazole