Phencyclidine receptors in brain and spinal cord of spontaneously hypertensive rats aged 4-16 wk.
OBJECTIVE
To study the relationship between the density of phencyclidine [1-(1-phenylcyclohexyl)piperidine hydrochloride, Phe] receptor binding sites in brain and thoracic spinal cord (T4-6) and the development of hypertension in spontaneously hypertensive rat (SHR).


METHODS
The density of Phe binding sites was determined by autoradiography using [3H]Phe in 4-, 8-, 12- and 16-wk-old rats.


RESULTS
There were fewer Phe binding sites in the hippocampus and dorsal horn of thoracic spinal cord of SHR at 12 and 16 wk (P < 0.01), when hypertension has established; while at 4 wk of age, before the development of hypertension, more Phe binding sites were found in SHR. As blood pressure began to rise at 8 wk, SHR had more Phe binding sites in hippocampus vs WKY, but no difference was seen between 2 strains in the dorsal horn of thoracic spinal cord.


CONCLUSIONS
Phe receptors might be involved in the genesis of SHR hypertension.
Yin
X
X
Department of Neurobiology, Shanghai Medical University, China.
Zhu
Y H
YH
Xu
S F
SF
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017478:Receptors, Phencyclidine / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D017478:Receptors, Phencyclidine