Fibroid growth in response to high-dose progestogen.
OBJECTIVE
To challenge the conventional belief that leiomyomata are estrogen-dependent tumors by presentation of a case report suggesting high-dose progestogen therapy is associated with a dramatic increase in size of a fibroid uterus.


METHODS
Case report.


METHODS
British university hospital.


METHODS
One white woman treated with tamoxifen and high-dose megestrol acetate for breast carcinoma.


METHODS
Megestrol acetate therapy withdrawn.


METHODS
Uterine size.


RESULTS
While taking tamoxifen and high-dose megestrol acetate, the patient suffered a dramatic increase in size of her fibroid uterus, which reversed when the progestogen was withdrawn.


CONCLUSIONS
This case report suggests that P may be important in fibroid growth.
Harrison-Woolrych
M
M
Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, United Kingdom.
Robinson
R
R
D001943:Breast Neoplasms / Q000188:drug therapy; D002277:Carcinoma / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging*; D008535:Megestrol / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D019290:Megestrol Acetate; D008875:Middle Aged; D011372:Progestins / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging*
D011372:Progestins; D013629:Tamoxifen; D008535:Megestrol; D019290:Megestrol Acetate