Translocation 11;14 in newly diagnosed chronic myelogenous leukemia.
In patients with chronic myelogenous leukemia (CML), the Philadelphia chromosome may be associated with a number of other cytogenetic lesions. However, t(11;14)(q13;q32), found mainly in B-cell lymphoproliferative disorders, has not been previously reported in Ph-positive CML. We describe a patient with hematologically typical chronic phase CML in whom both cytogenetic lesions were found at diagnosis.
Magdalinski
A
A
Department of Neoplastic Diseases, Hahnemann University Hospital, Philadelphia, PA 19102, USA.
Drwinga
H
H
Crilley
P
P
Lasota
J
J
Brodsky
I
I
Croce
C M
CM
Nowell
P C
PC
Marks
D I
DI
D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic