title: [Main steps in the skeletal myogenesis in man].
abstract: During the metabolic differentiation of developing human skeletal muscle fibers, two different generations of fibers can be characterised by their profiles of protein expression (in particular of the myosin heavy chains). This differentiation is regulated by both genetic and epigenetic factors (motor innervation, levels of thyroid hormone). The anomalies in different muscle pathologies can be better understood by comparison with the modifications occurring during normal skeletal muscle development.
authors.affiliation: Laboratoire de Pathologie Pédiatrique, Hôpital Saint-Vincent-de-Paul, Paris.
authors.forename: J P
authors.initials: JP
authors.lastname: Barbet
authors.forename: G S
authors.initials: GS
authors.lastname: Butler-Browne
authors.forename: V
authors.initials: V
authors.lastname: Mouly
mesh_terms: D005314:Embryonic and Fetal Development; D006801:Humans; D018482:Muscle, Skeletal / Q000196:embryology* / Q000378:metabolism; D009218:Myosins / Q000737:chemistry / Q000378:metabolism
chemical_list: D009218:Myosins
vernacular_title: Les principales étapes de la myogenèse squelettique chez l'Homme.