The incidence of factor VIII inhibitors in the United Kingdom, 1990-93. Inhibitor Working Party. United Kingdom Haemophilia Centre Directors Organization.
Reports of all the factor VIII inhibitors arising in the United Kingdom in patients with haemophilia A during the years 1990-93 have been collated by the United Kingdom Haemophilia Centre Directors Organization. 32 new inhibitors were reported during this period, giving an average incidence of new inhibitors of 1.5 per 1000 patients registered per year. Although most occurred in patients with severe haemophilia under the age of 10, 29% occurred in patients whose VIIIC was > 3 iu/dl, and 38% in patients over the age of 10 years. The incidence of inhibitors rose during the study period, but this change was not statistically significant.
Colvin
B T
BT
Department of Haematology, Royal London Hospital, Whitechapel.
Hay
C R
CR
Hill
F G
FG
Preston
F E
FE
D000293:Adolescent; D000328:Adult; D000368:Aged; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006467:Hemophilia A / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D006113:United Kingdom / Q000453:epidemiology
D005169:Factor VIII