title: [The pharmacokinetics and pharmacodynamics of prophylactic doses of aspirin in pregnant women from a group at risk for placental insufficiency].
abstract: The pharmacokinetics and pharmacodynamics of small-dose aspirin (60 mg/day) were studied during the second to the third trimesters in pregnant females at a high risk of placental insufficiency. In the group of pregnant women with uncomplicated pregnancies (n = 16), the aspirin kinetic changes which presented with a lower concentration-time index, higher total clearance and larger distribution volume were associated with the gestational age. Similar changes were revealed in the group of pregnant women (n = 4) with advanced placental insufficiency. The findings suggest that the optimal therapeutical aspirin doses should be chosen by the gestational age rather than by the severity of placental insufficiency.
authors.forename: G U
authors.initials: GU
authors.lastname: Asymbekova
authors.forename: P D
authors.initials: PD
authors.lastname: Banartsev
authors.forename: T B
authors.initials: TB
authors.lastname: Ochan
authors.forename: B E
authors.initials: BE
authors.lastname: Rozenfel'd
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Folomeeva
authors.forename: S V
authors.initials: SV
authors.lastname: Pavlovich
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D001809:Blood Viscosity / Q000187:drug effects; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D010927:Placental Insufficiency / Q000097:blood / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012307:Risk Factors; D013997:Time Factors; D016216:Ultrasonography, Prenatal
chemical_list: D001241:Aspirin
vernacular_title: Farmakokinetika i farmakodinamika profilakticheskikh doz aspirina u beremennykh gruppy riska po platsentarnoĭ nedostatochnosti.