title: Evaluation of coronary artery disease by dipyridamole echocardiography test.
abstract: Role of oral dipyridamole echocardiography test (DET) was evaluated in 50 patients with effort angina. All patients underwent coronary angiography, the day after oral DET. The echo studies were performed at rest and 65 +/- 15 minutes after 300 mg of oral dipyridamole. Segmental wall motion was analysed in a 16 segment model and a wall motion score index (WMSI) was generated for the entire left ventricle both at rest and following the drug. WMSI was significantly higher after oral dipyridamole, (p < 0.001) compared to resting condition with increased sensitivity (86% vs 74%). When results of DET were compared with coronary angiography, the correlation of WMSI was statistically significant in three vessel disease (p < 0.001), two vessel disease (p < 0.001) as well as for left anterior descending lesions (p < 0.001). However, it was insignificant for single vessel disease, viz, right coronary artery and circumflex artery. Thus we conclude that oral DET is a safe, inexpensive, sensitive and non-exercise dependent method for demonstrating myocardial ischaemia with high diagnostic accuracy.
authors.affiliation: Institute of Post Graduate Medical Education and Research, Calcutta.
authors.forename: A K
authors.initials: AK
authors.lastname: Khan
authors.forename: S
authors.initials: S
authors.lastname: Roy
authors.forename: A
authors.initials: A
authors.lastname: Dasbiswas
authors.forename: R
authors.initials: R
authors.lastname: Bhattacharjee
authors.forename: A
authors.initials: A
authors.lastname: Biswas
authors.forename: D
authors.initials: D
authors.lastname: Choudhury
authors.forename: S K
authors.initials: SK
authors.lastname: Chakravarty
authors.forename: S S
authors.initials: SS
authors.lastname: Chatterjee
authors.forename: A K
authors.initials: AK
authors.lastname: Maity
mesh_terms: D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004176:Dipyridamole; D004452:Echocardiography / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D012680:Sensitivity and Specificity
chemical_list: D004176:Dipyridamole