title: Comparative in vitro activities of L-695,256, a novel carbapenem, against gram-positive bacteria.
abstract: The in vitro activity of a prototype 2-aryl carbapenem, L-695,256, against gram-positive bacteria was examined. All streptococci and oxacillin-susceptible and -resistant staphylococci were inhibited at concentrations of < or = 0.125, < or = 0.125, and 4 micrograms/ml, respectively. The activity of L-695,256 was superior to that of imipenem against other organisms intrinsically resistant to beta-lactams.
authors.affiliation: Department of Medicine, Deaconess Hospital, Boston, Massachusetts 02215, USA.
authors.forename: G
authors.initials: G
authors.lastname: Malanoski
authors.forename: L
authors.initials: L
authors.lastname: Collins
authors.forename: C T
authors.initials: CT
authors.lastname: Eliopoulos
authors.forename: R C
authors.initials: RC
authors.lastname: Moellering
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007093:Imidazoles; C093180:L 695256