title: Tissue plasminogen activator for the treatment of postoperative intraocular fibrinous membranes following cataract surgery.
abstract: We report on our first two patients treated by intracameral application of tissue plasminogen activator (tPA) for dissolving fibrinous exsudates. Both patients had developed fibrin membranes in the pupillary plane and in the anterior chamber several days after cataract surgery. Injection of 25 micrograms tPA into the anterior chamber resulted in complete dissolution of the fibrin within 1 h of its application.
authors.affiliation: Städtisches Krankenhaus München-Harlaching, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Schmitz
authors.forename: J H
authors.initials: JH
authors.lastname: Greite
authors.forename: E M
authors.initials: EM
authors.lastname: Bartenschlager
mesh_terms: D000368:Aged; D000867:Anterior Chamber / Q000378:metabolism* / Q000473:pathology; D002387:Cataract Extraction; D005122:Exudates and Transudates; D005128:Eye Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D005342:Fibrinolysis; D006801:Humans; D007267:Injections; D011183:Postoperative Complications / Q000188:drug therapy* / Q000473:pathology; D011994:Recombinant Proteins / Q000008:administration & dosage; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D011994:Recombinant Proteins; D005337:Fibrin; D010959:Tissue Plasminogen Activator