title: Effect of iontophoretic patterns on in vivo antidiuretic response to desmopressin acetate administered transdermally.
abstract: The effects of concentration, amperage and duration on the antidiuretic response induced by iontophoretic delivery of desmopressin acetate (DDAVP) were examined using a diabetes insipidus model in rats. A higher current density brought about a larger and longer antidiuretic response. Prolonged iontophoretic duration caused an overdose. Repeated short iontophoretic treatments with lower current density maintained a constant response with a short lag time and a rapid disappearance of pharmacological response immediately after cessation of the final treatment. This type of iontophoresis substantially reduced the inter-subject variability of response as compared to the response using an intranasal route of administration.
authors.affiliation: Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakakura
authors.forename: M
authors.initials: M
authors.lastname: Terajima
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: E
authors.initials: E
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Kuroda
mesh_terms: D000279:Administration, Cutaneous; D000281:Administration, Intranasal; D000818:Animals; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D062787:Drug Overdose; D007478:Iontophoresis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption
chemical_list: D003894:Deamino Arginine Vasopressin