[Biochemical bases for the antiseizure role of the pineal gland].
Metabolism of serotonin was studied in pineal gland of Wistar rats with low and high rate of audio excitability as well as in the Krushinsky-Molodkina rat population genetically predisposed to audio-dependent convulsions. Intensive turnover of serotonin via N-acetyl serotonin into melatonin was found in pineal gland of rats insensitive to sensory stimulus, whereas the rate of this response was decreased in the gland tissue of animals sensitive to audio effects as well as inhibition of serotonin turnover into melatonin was noticed in pineal gland of rats predisposed genetically to audio-dependent convulsions.
Bondarenko
L A
LA
Sergienko
N G
NG
D000161:Acoustic Stimulation; D000818:Animals; D005260:Female; D010870:Pineal Gland / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology*; D012701:Serotonin / Q000378:metabolism
D012701:Serotonin
Biokhimicheskie osnovy protivosudorozhnoĭ roli pineal'noĭ zhelezy.