[The pharmacokinetics and pharmacodynamics of prophylactic doses of aspirin in pregnant women from a group at risk for placental insufficiency].
The pharmacokinetics and pharmacodynamics of small-dose aspirin (60 mg/day) were studied during the second to the third trimesters in pregnant females at a high risk of placental insufficiency. In the group of pregnant women with uncomplicated pregnancies (n = 16), the aspirin kinetic changes which presented with a lower concentration-time index, higher total clearance and larger distribution volume were associated with the gestational age. Similar changes were revealed in the group of pregnant women (n = 4) with advanced placental insufficiency. The findings suggest that the optimal therapeutical aspirin doses should be chosen by the gestational age rather than by the severity of placental insufficiency.
Asymbekova
G U
GU
Banartsev
P D
PD
Ochan
T B
TB
Rozenfel'd
B E
BE
Sariev
A K
AK
Folomeeva
I Iu
IIu
Pavlovich
S V
SV
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D001809:Blood Viscosity / Q000187:drug effects; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D010927:Placental Insufficiency / Q000097:blood / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012307:Risk Factors; D013997:Time Factors; D016216:Ultrasonography, Prenatal
D001241:Aspirin
Farmakokinetika i farmakodinamika profilakticheskikh doz aspirina u beremennykh gruppy riska po platsentarnoĭ nedostatochnosti.