title: Arrhythmia prevalence during ambulatory electrocardiographic monitoring of beagles.
abstract: Ambulatory ECG, approximately 18 to 24 hours in duration, were obtained from 113 male and 115 female clinically normal, purpose-bred Beagles. The ECG analyzed semi-automatically (44 males, 46 females) were evaluated for heart rate, ventricular ectopic complexes (VEC), bradycardia, and sinus pause; those analyzed by visual inspection (69 males, 69 females) were evaluated for VEC, second-degree atrioventricular block, and supraventricular escape complexes. Mean heart rate was highest at times of maximal human contact (eg, feeding, cleaning) and lowest at periods of no human contact. Bradycardia was observed in 27 of 44 males (61.4%) and 18 of 46 females (39.1%). Sinus pause was identified in 33 of 44 males (75%) and 30 of 46 females (65.2%). Frequency of bradycardia and sinus pause tended to vary inversely with mean heart rate. Ventricular ectopic complexes were detected in 18.8 to 26.1% of the ECG analyzed by use of either method. Although VEC runs and bigeminy were observed, most VEC were single and occurred sporadically. Second-degree atrioventricular block was observed in 6 of 69 males (8.7%) and 14 of 69 females (20.3%); episodes often were single and occurred sporadically. Supraventricular escape complex occurred in 2 of 69 females (2.9%). Multiple types of abnormal complexes were observed in 2 of 69 males (2.9%) and 6 of 69 females (8.7%). Among clinically normal Beagles, ambulatory electrocardiography detects a higher percentage of dogs with VEC, second-degree atrioventricular block, and supraventricular ectopic complexes than does resting electrocardiography.
authors.affiliation: Department of Pathology and Experimental Toxicology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co, Ann Arbor, MI 48105, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Ulloa
authors.forename: B J
authors.initials: BJ
authors.lastname: Houston
authors.forename: D M
authors.initials: DM
authors.lastname: Altrogge
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000662:veterinary*; D004283:Dog Diseases / Q000453:epidemiology*; D004285:Dogs; D015716:Electrocardiography, Ambulatory / Q000592:standards / Q000662:veterinary*; D005260:Female; D008297:Male; D015995:Prevalence