Platin salts-induced hemolytic anemia: cisplatin- and the first case of carboplatin-induced hemolysis.
Anemia is a common side effect of cisplatin, especially after repeated infusions. The primary mechanisms is a myelosuppression caused by cisplatin's interference with iron metabolism, resulting in a lower count of red cell precursors. Some authors report a hemolytic anemia similar to penicillin-induced anemia, in which hemolysis is caused by an antiglobulin antibody directed against red cell membrane-bound cisplatin. The authors report two cases of cisplatin-induced anemia and suggest that the immune-complex hypothesis is responsible for hemolysis. The first case of carboplatin-induced hemolysis is also reported. Mechanisms of hemolysis and clinical practice are discussed.
Maloisel
F
F
Service d'Onco-Hématologie, Hôpital de Hautepierre, Strasbourg, France.
Kurtz
J E
JE
Andres
E
E
Gorodetsky
C
C
Dufour
P
P
Oberling
F
F
D000328:Adult; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D016190:Carboplatin / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged
D016190:Carboplatin; D002945:Cisplatin