[Guillain-Barré syndrome associated with anti-GalNAc-GD1a antibody subsequent to Campylobacter jejuni enteritis].
We report a 15-year-old man with Guillain-Barré syndrome (GBS) following Campylobacter jejuni enteritis. Neurologic examination revealed distal muscle weakness and mild disturbance of superficial sense on right plantar area. Serial electrophysiologic studies indicated that the predominant process was axonal degeneration of motor nerves. Thin-layer chromatography with immunostaining revealed that serum IgG strongly reacted with GalNAc-GD1a and weakly with GM2, but did not react with GM1. This is the first report of GBS subsequent to C. jejuni enteritis associated with anti-GalNAc-GD1a antibody.
Tsuda
N
N
Department of Neurology, Yamaguchi University School of Medicine.
Negoro
K
K
Morimatsu
M
M
Saito
K
K
Yuki
N
N
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis*; D002169:Campylobacter Infections / Q000150:complications* / Q000276:immunology; D016123:Campylobacter jejuni; D004751:Enteritis / Q000150:complications* / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D011129:Polyradiculoneuropathy / Q000209:etiology / Q000276:immunology*
D001323:Autoantibodies; D005732:Gangliosides; C055253:IV(4)-galactosyl-N-acetylganglioside GD1a