Dietary changes in fasting levels of factor VII coagulant activity (FVII:C) are accompanied by changes in factor VII protein and other vitamin K-dependent proteins.
The mechanisms behind dietary effects on fasting coagulant activity of factor VII (FVII:C) are not clarified. In the present study of 15 young volunteers, two experimental diets differing in composition of saturated fatty acids (C18:0 [diet S] or C12:0 + C14:0 [diet ML]) were served for 3 weeks each. Fasting blood samples were collected before and after the dietary regimen and analysed for triglycerides, FVII:C, and protein concentrations of FVII, FII, FX, protein C, CRP, albumin, fibrinogen, and F1 + 2. FVII:C was significantly reduced on diet S compared with diet ML. This was accompanied by a decrease in FVII protein, F1 + 2 and the vitamin K-dependent proteins FII, FX, and protein C. In contrast, no changes were observed in triglycerides, FVII:C/FVII:Ag, albumin and CRP. Fibrinogen was increased on diet S compared with diet ML. Our findings suggest that the change in fasting FVII:C was part of a general change in concentrations of vitamin K-dependent proteins.
Bladbjerg
E M
EM
Institute for Thrombosis Research, South Jutland University Centre, Esbjerg, Denmark.
Tholstrup
T
T
Marckmann
P
P
Sandström
B
B
Jespersen
J
J
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D004041:Dietary Fats / Q000494:pharmacology*; D005167:Factor VII / Q000378:metabolism*; D005170:Factor X / Q000378:metabolism; D005215:Fasting / Q000097:blood*; D006801:Humans; D008297:Male; D011486:Protein C / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D014812:Vitamin K / Q000502:physiology*
D001798:Blood Proteins; D004041:Dietary Fats; D011486:Protein C; D014812:Vitamin K; D005167:Factor VII; D011516:Prothrombin; D005170:Factor X