title: Persistence of sodium monofluoroacetate in rabbits and risk to non-target species.
abstract: 1. Sodium monofluoroacetate (1080), a vertebrate pesticide used in New Zealand, was administered orally to rabbits at two dose levels (sub-lethal and lethal) to determine how long 1080 would persist in plasma, liver, kidney, and muscle so that the risk of consumption of meat from lethally or sub-lethally poisoned rabbits by non-target species could be assessed. 2. The plasma elimination half-life in rabbits receiving a sub-lethal dose was 1.1 h. Retention of 1080 in tissue was greater in rabbits dosed with a lethal dose than in those that received a sub-lethal dose. Irrespective of the dose level, concentration of 1080 in muscle, kidney, and liver was substantially lower than in the plasma. 3. Poisoning of dogs is possible because of their extreme susceptibility to 1080. Poisoning of birds is less likely. The risk of secondary poisoning is reduced as the concentration of 1080 declines in putrefying carcasses.
authors.affiliation: Animal and Veterinary Sciences Group, Lincoln University, Canterbury, New Zealand.
authors.forename: S R
authors.initials: SR
authors.lastname: Gooneratne
authors.forename: C T
authors.initials: CT
authors.lastname: Eason
authors.forename: C J
authors.initials: CJ
authors.lastname: Dickson
authors.forename: H
authors.initials: H
authors.lastname: Fitzgerald
authors.forename: G
authors.initials: G
authors.lastname: Wright
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000493:pharmacokinetics*; D005463:Fluoroacetates / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000506:poisoning; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009520:New Zealand; D010571:Pest Control / Q000592:standards*; D011817:Rabbits; D012307:Risk Factors; D012378:Rodenticides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000506:poisoning; D014018:Tissue Distribution
chemical_list: D005463:Fluoroacetates; D012378:Rodenticides; C014815:fluoroacetic acid