Antibodies to the 65 kDa mycobacterial stress protein in west Africans with rheumatoid arthritis, tuberculosis and malaria.
We have studied IgG antibodies to recombinant mycobacterial 65 kDa heat-shock protein in West African rheumatoid arthritis (RA) patients and local control groups, including those with tuberculosis or malaria. Mean levels were higher among the patients with RA than among healthy controls, but did not achieve statistical significance. Our findings may relate to the level of mycobacterial exposure in West Africa.
Adebajo
A O
AO
Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge.
Williams
D G
DG
Hazleman
B L
BL
Maini
R N
RN
D000354:Africa, Western / Q000208:ethnology; D000907:Antibodies, Bacterial / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology; D044383:Black People; D018834:Chaperonin 60; D018833:Chaperonins / Q000276:immunology*; D006801:Humans; D008288:Malaria / Q000276:immunology*; D009161:Mycobacterium / Q000276:immunology; D011446:Prospective Studies; D014376:Tuberculosis / Q000208:ethnology / Q000276:immunology*
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D018834:Chaperonin 60; C074119:heat-shock protein 65, Mycobacterium; D018833:Chaperonins