Effects of single and combined application of anti-cancer drugs on cervical adenocarcinoma. I. Antitumor activity in vitro.
BACKGROUND
Establishment of effective combination chemotherapy regimen for patients with an adenocarcinoma of the uterine cervix has been long-awaited because there has been no documentation concerning chemosensitivity of this tumor against conventional antitumor agents.


METHODS
To search for an effective combination regimen, 15 conventional antitumor drugs were tested for growth inhibitory effects on five different cervical adenocarcinoma cell lines.


RESULTS
Etoposide, mitomycin C, adriamycin, epirubicin, and vinblastine, were singularly effective. Effects of combination chemotherapy were also tested using the above five antitumor agents plus interferon-gamma. Etoposide, mitomycin C, and interferon-gamma were the most effective when given in combination.


CONCLUSIONS
Combined treatment with the above three drugs seems worthy of consideration for clinical application.
Hara
K
K
Department of Obstetrics and Gynecology, Saga Medical School, Japan.
Iwasaka
T
T
Matsuo
N
N
Nakao
Y
Y
Yokoyama
M
M
Yamasaki
F
F
Mvula
M
M
Sugimori
H
H
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002460:Cell Line; D003131:Combined Modality Therapy; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000627:therapeutic use; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011994:Recombinant Proteins; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery
D011994:Recombinant Proteins; D016685:Mitomycin; D005047:Etoposide; D007371:Interferon-gamma