Structures and absolute configurations of antibiotics of the oligosporon group from the nematode-trapping fungus Arthrobotrys oligospora.
Spectroscopic data define the structures of three new antibiotics, 4',5'-dihydro-oligosporon (4), hydroxyoligosporon (5) and 10',11'-epoxyoligosporon (6) from the nematode-trapping fungus Arthrobotrys oligospora, and confirm the structures of the recently reported antibiotics oligosporon (1) and oligosporol B (3). The absolute configuration of the substituted 7-oxabicyclo[4.1.0]hept-3-ene nucleus of these metabolites is determined by circular dichroic spectroscopy. Oligosporon (1) and its dihydro-derivative (4) represent the second and most complex structural type of nematocidal metabolite to be characterised from cultures of nematophagous fungi.
Anderson
M G
MG
Research School of Chemistry, Australian National University, Canberra.
Jarman
T B
TB
Rickards
R W
RW
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000969:Antinematodal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002942:Circular Dichroism; D004852:Epoxy Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006189:Haemonchus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C094352:10',11'-epoxyoligosporon; C094356:4',5'-dihydrooligosporon; D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D004852:Epoxy Compounds; C094354:hydroxyoligosporon