[Experimental study on acute hypoxia in newborn rabbits].
To investigate the hypoxic-ischemic damage of perinatal asphyxia, the acute hypoxic models of newborn rabbits were established and the effects of ligustrazine and anisodamine on pulmonary arterial pressure (PAP), dural blood flow (DBF) and blood gas of the hypoxia rabbits were observed. Acute hypoxia was caused by inhalation of 10% O2 + 90% N2 mixture. PaO2 was obviously reduced, PAP and DBF were obviously increased. But PAP in ligustrazine group did not increase and the elevated level of PAP in the anisodamine group was lower than the control. DBF and PaO2 was not affected by using both of the drugs. Ligustrazine and anisodamine might be effective for preventing and treating newborn persistent pulmonary hypertension.
Wang
D
D
PUMC Hospital, CAMS, Beijing.
Zhang
H
H
Sun
R
R
Xu
J
J
Zhang
S
S
D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004388:Dura Mater / Q000098:blood supply; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D011651:Pulmonary Artery; D011719:Pyrazines / Q000494:pharmacology*; D011817:Rabbits; D012991:Solanaceous Alkaloids / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D011719:Pyrazines; D012991:Solanaceous Alkaloids; C003922:anisodamine; C017953:tetramethylpyrazine