[Distribution of free amino acids and related compounds in ocular fluids of rat--I. Aging and inherited cataracts].
The distribution of free amino acids and their related compounds has been determined in the aqueous humors of Wistar strain and Ihara cataract f-strain (ICR) aging rats. Taurine was the most abundant amino acid in aqueous humors except in ICR rats of 16 and 70 weeks. It was supposed that the increase of serine and glutamine, and the decrease of aspartate, proline and glycine in aqueous humors were related to aging. There were interesting changes in amino acids related to opacity of lens, concentration of taurine was lower than that of Wistar rats in ICR rats of 4, 16, and 70 weeks, alanine and citrulline increased in Wistar rats and decreased in ICR rats, and histidine increased in ICR rats with aging. The changes in free amino acids in aqueous humors were the greatest in ICR rats, and these data will provide useful clues for the formation of cataract and the transportation of amino acids.
Iijima
T
T
Second Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan.
Sato
T
T
Kadofuku
T
T
Takeda
M
M
Kinohira
Y
Y
Yabe
N
N
Koide
R
R
D000375:Aging / Q000378:metabolism*; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D001082:Aqueous Humor / Q000737:chemistry*; D002386:Cataract / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids