Beta-carotene (provitamin A) decreases the severity of CCl4-induced hepatic inflammation and fibrosis in rats.
Earlier data from experiments in rats have shown that administration of retinyl esters (vitamin A) strongly influences the effects of CCl4 on the liver. The accumulation of collagen was inhibited, but an increase in CCl4-toxicity with high mortality was observed. The present study was conducted to examine the effects of beta-carotene (provitamin A) on CCl4-related general and hepatic toxicity in rats. Oral administration of beta-carotene during CCl4-treatment resulted, biochemically, in a significantly lower increase in the hydroxyproline liver content and, histopathologically, in less severe liver fibrosis as compared with the liver of rats not treated with beta-carotene. The study also showed that beta-carotene administration could prevent the long-term loss of retinoids from the CCl4-injured liver. No significant toxic effects of beta-carotene, as previously found with retinyl esters (vitamin A), were observed. This experimental study suggests that beta-carotene has the therapeutic potential to decrease the severity of liver fibrosis without marked toxicity.
Seifert
W F
WF
TNO Institute of Ageing and Vascular Research, Leiden, The Netherlands.
Bosma
A
A
Hendriks
H F
HF
van Leeuwen
R E
RE
van Thiel-de Ruiter
G C
GC
Seifert-Bock
I
I
Knook
D L
DL
Brouwer
A
A
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology*; D002338:Carotenoids / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D005260:Female; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology*; D008111:Liver Function Tests; D051381:Rats; D011914:Rats, Inbred BN; D019207:beta Carotene
D019207:beta Carotene; D002338:Carotenoids; D003094:Collagen; D006909:Hydroxyproline