title: Osteonecrosis of the hip in sickle cell hemoglobinopathy.
abstract: Osteonecrosis secondary to sickle cell anemia and its genetic variants has many presentations depending on the age of onset and the extent of femoral head involvement. Total hip arthroplasty provides the greatest opportunity for clinical improvement of all treatment options, though early and late complication rates are high. Technical difficulties of total hip arthroplasty are related to marrow hyperplasia and the presence of sclerotic intramedullary bone. Surgical complications related to sickle cell hemoglobinopathy include vaso-occlusive crises, congestive heart failure, major transfusion reactions, intraoperative femoral fracture, femoral perforation, late aseptic loosening of acetabular and femoral components, and sepsis.
authors.affiliation: University of Illinois, Chicago College of Medicine, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Moran
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D005271:Femur Head Necrosis / Q000209:etiology* / Q000601:surgery; D006621:Hip Joint / Q000000981:diagnostic imaging; D006622:Hip Prosthesis; D006801:Humans; D008875:Middle Aged; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections; D011859:Radiography