Hypersensitivity hepatitis due to pyrazinamide.
Pyrazinamide hepatotoxicity is considered secondary to a direct and dose-related toxic effect. At currently used doses, pyrazinamide provides effective short-term treatment and is free from serious side effects. We report a case of pyrazinamide-induced hepatitis for which the rechallenge data strongly suggest a hypersensitivity mechanism.
Corbella
X
X
Department of Infectious Diseases, Hospital de Bellvitge, University of Barcelona, Spain.
Vadillo
M
M
Cabellos
C
C
Fernandez-Viladrich
P
P
Rufi
G
G
D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008875:Middle Aged; D011718:Pyrazinamide / Q000009:adverse effects*
D011718:Pyrazinamide