title: Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.
abstract: We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. Our cases include a 35-year-old woman with (sub)fulminant hepatitis, a 67-year-old woman with macronodular cirrhosis, and a 68-year-old man with severe chronic active hepatitis and cirrhosis, with positivity of anti-smooth muscle antibodies. Two patients died. We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis. Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.
authors.affiliation: Academic Hospital, Free University of Brussels, Belgium.
authors.forename: M L
authors.initials: ML
authors.lastname: Hautekeete
authors.forename: J
authors.initials: J
authors.lastname: Henrion
authors.forename: S
authors.initials: S
authors.lastname: Naegels
authors.forename: A
authors.initials: A
authors.lastname: DeNeve
authors.forename: M
authors.initials: M
authors.lastname: Adler
authors.forename: C
authors.initials: C
authors.lastname: Deprez
authors.forename: G
authors.initials: G
authors.lastname: Devis
authors.forename: G
authors.initials: G
authors.lastname: Klöppel
mesh_terms: D000328:Adult; D000368:Aged; D001553:Benzbromarone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D056487:Chemical and Drug Induced Liver Injury, Chronic; D017809:Fatal Outcome; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000473:pathology; D006521:Hepatitis, Chronic / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000473:pathology; D008297:Male; D013924:Thrombophlebitis / Q000188:drug therapy / Q000473:pathology; D014689:Venous Insufficiency / Q000188:drug therapy / Q000473:pathology
chemical_list: D005343:Fibrinolytic Agents; C004528:benzarone; D001553:Benzbromarone