Phase behavior of mixtures of cholesterol and saturated phosphatidylglycerols.
The interaction of cholesterol with a series of saturated phosphatidylglycerols was investigated using differential scanning calorimetry and X-ray diffraction. We find that the miscibility of cholesterol in phosphatidylglycerol bilayers is lower than in the corresponding phosphatidylcholine bilayers and decreases with increasing acyl chain length of the phospholipid. The influence of the negative charge of the phosphatidylglycerol on cholesterol miscibility is discussed.
Borochov
N
N
Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.
Wachtel
E J
EJ
Bach
D
D
D002152:Calorimetry, Differential Scanning; D002784:Cholesterol / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry; D006860:Hydrogen Bonding; D008051:Lipid Bilayers / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry; D010715:Phosphatidylglycerols / Q000737:chemistry*; D010718:Phosphatidylserines / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics; D014961:X-Ray Diffraction
D005227:Fatty Acids; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010718:Phosphatidylserines; D002784:Cholesterol