A modified liquid diet of chronic ethanol administration: validation by ethanol withdrawal syndrome in rats.
The validity of a modified liquid diet prepared from cow's milk, 7.2% ethanol, vitamin A and sucrose mixture has been investigated for chronic ethanol administration in rats. The rats fed by the modified liquid diet lost 3.8% of their body weight along 20 days. The mean ethanol consumption was in the range of 12.6 to 17.6 g kg-1 day-1. The blood ethanol level just before the withdrawal of ethanol was found to be 301.38 +/- 36.68 mg dl-1. A severe ethanol withdrawal syndrome was observed after 20-day exposure to ethanol in the modified liquid diet. The results suggest that the modified liquid diet can be used satisfactorily for chronic ethanol administration in rats.
Uzbay
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IT
Department of Pharmacology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey.
Kayaalp
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SO
D000428:Alcohol Drinking; D000437:Alcoholism / Q000209:etiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D005526:Food, Formulated; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D013997:Time Factors
D000431:Ethanol