[Assessment of anxiolytics (1)--Geller-type conflict tests].
The Geller-type conflict test and its modified tests, which are based on operant conditioning, have been applied for preclinical evaluation of the anxiolytic effect of drugs in parallel with the clinical use of benzodiazepines. Here, the author describes the experimental procedures of the Geller-type conflict test, including its modified tests, using mice and rats in detail. The effects of drugs, particularly benzodiazepines and 5-HT1A receptor agonists, on the established conflict behaviors in rats and mice are also presented.
Kuribara
H
H
Division for Behavior Analysis, Gunma University School of Medicine, Maebashi, Japan.
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003220:Conflict, Psychological; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D051379:Mice; D051381:Rats; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D017366:Serotonin Receptor Agonists; D001569:Benzodiazepines