The synthesis of novel HIV-protease inhibitors.
The syntheses, enzyme inhibition and antiviral activity of potent HIV-protease inhibitors containing novel beta-hydroxy ether and thioethers based on the transition state mimetic concept are discussed.
Girijavallabhan
V M
VM
Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Bennett
F
F
Patel
N M
NM
Ganguly
A K
AK
Dasmahapatra
B
B
Butkiewicz
N
N
Hart
A
A
D000595:Amino Acid Sequence; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D015497:HIV-1 / Q000187:drug effects; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D004987:Ethers; D017320:HIV Protease Inhibitors; D013440:Sulfides