title: 35% CO2 challenge in panic and mood disorders.
abstract: 20 patients with Panic Disorder (PD), 19 patients with Mood Disorder (MD) and 20 healthy controls inhaled one vital capacity of 35% CO2-65% O2 gas mixture and of compressed air in a double-blind, random, cross-over design. Only PD patients showed a strong reaction to 35% CO2 while MD patients and controls did not react significantly. These results support the specificity of the 35% CO2 challenge in PD patients and suggest that PD and MD are separate disorders.
authors.affiliation: Department of Neuropsychiatric Sciences, University of Milan, San Raffaele Hospital, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Perna
authors.forename: B
authors.initials: B
authors.lastname: Barbini
authors.forename: S
authors.initials: S
authors.lastname: Cocchi
authors.forename: A
authors.initials: A
authors.lastname: Bertani
authors.forename: M
authors.initials: M
authors.lastname: Gasperini
mesh_terms: D000328:Adult; D000368:Aged; D001143:Arousal / Q000187:drug effects; D002245:Carbon Dioxide; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects; D016584:Panic Disorder / Q000175:diagnosis* / Q000523:psychology; D010555:Personality Inventory; D011237:Predictive Value of Tests; D012016:Reference Values
chemical_list: D002245:Carbon Dioxide