title: Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.
abstract: Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.
authors.affiliation: Gladstone Institute of Cardiovascular Disease, Department of Pathology, University of California, San Francisco, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Mahley
authors.forename: B P
authors.initials: BP
authors.lastname: Nathan
authors.forename: S
authors.initials: S
authors.lastname: Bellosta
authors.forename: R E
authors.initials: RE
authors.lastname: Pitas
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology*; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E