title: [Antibiotic prophylaxis in gynecologic surgery].
abstract: Hysterectomies are contaminated procedures; surgical wound related sepsis ranges from 10 to 25%. Several randomised controlled studies demonstrated a significant benefit with prophylactic antibiotics. The study results were more controversial for abdominal hysterectomies. Ureidopenicillins, cephamycins and other antibacterial agents active on Gram negative rods and anaerobes can be recommended as a preoperative flash at anaesthesia induction, followed by a second injection whenever the procedure duration exceeds 3 hours. In case of extended hysterectomy for cancer, broad spectrum antibiotic prophylaxis is usual; some recent studies demonstrated the efficacy of a short duration antibacterial agent use. Mastectomies are at low risk for postoperative infection. Antibacterial prophylaxis is common, especially in plastic surgery.
authors.affiliation: Service des Maladies Infectieuses et tropicales, Hôtel-Dieu, CHU de Clermont-Ferrand.
authors.forename: J
authors.initials: J
authors.lastname: Beytout
authors.forename: A
authors.initials: A
authors.lastname: Mansoor
authors.forename: H
authors.initials: H
authors.lastname: Laurichesse
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D008408:Mastectomy / Q000009:adverse effects; D011292:Premedication; D016032:Randomized Controlled Trials as Topic; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014594:Uterine Neoplasms / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Antibioprophylaxie en chirurgie gynécologique.