title: Curative treatment of clinical stage II endometrial carcinoma.
abstract: In a retrospective study of 54 patients we compared three treatment policies of clinical stage II endometrial carcinoma: One group of patients (n = 29) was surgically staged with histological examination made at surgery and treated by abdominal total hysterectomy with bilateral salpingo-oophorectomy. In case of cervical infiltration by tumour, a pelvic node sampling was added. The second group was treated by radical hysterectomy (n = 9) and the third group of patients (n = 16) was treated by abdominal total hysterectomy with bilateral oophorectomy only. The median follow-up time was 68 months. The overall five year-survival was 64%. The overall five year-survival rates according to surgical procedure were not significantly different. The survival curves were significantly different from each other as were those according to surgical stage and age. In a multivariant analysis stage, grading and age proved to have an independent relation with the survival rate whereas type of surgical procedure, depth of myometrial infiltration and type of radiotherapy had no influence on survival. Intraoperative histological staging allows adaption of treatment to the true stage, thus minimising treatment-related morbidity.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Berne, Switzerland.
authors.forename: W
authors.initials: W
authors.lastname: Haenggi
authors.forename: A
authors.initials: A
authors.lastname: Gasser
authors.forename: J
authors.initials: J
authors.lastname: Feyereisl
authors.forename: R
authors.initials: R
authors.lastname: Maibach
authors.forename: S
authors.initials: S
authors.lastname: Spoerri
authors.forename: R
authors.initials: R
authors.lastname: Greiner
authors.forename: E
authors.initials: E
authors.lastname: Dreher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D004717:Endometrium / Q000473:pathology; D005187:Fallopian Tubes / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010052:Ovariectomy; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016896:Treatment Outcome