title: Enterococcus faecalis colonisation and endocarditis in five intensive care patients as late sequelae of selective decontamination.
abstract: OBJECTIVE
  To describe Enterococcus faecalis colonisation and endocarditis in 5 intensive care patients after treatment with selective decontamination (SDD).
  
  
  METHODS
  Intensive care unit (ICU) in a general hospital.
  
  
  METHODS
  The patients were admitted to the ICU because of adult respiratory distress syndrome, polytrauma (2 patients), abdominal aortic surgery and gastrointestinal surgery. Because these patients needed mechanical ventilation they received systemic cefotaxime and SDD (polymyxin E, amphotericin B and norfloxacin).
  
  
  RESULTS
  Colonisation with E. faecalis was documented in all patients. Intravascular catheter-related infection with E. faecalis occurred in 4 patients. None of the patients received antibiotics active against, E. faecalis, because body temperature normalised after catheter removal. In the course of his ICU stay one patient died. Autopsy showed E. faecalis endocarditis. The other 4 patients recovered from their primary illness, but had to be readmitted after several months because of E. faecalis endocarditis. One of these patients died. One patient recovered of endocarditis, but one year later valve surgery was necessary. The other 2 patients needed acute valve replacement. The latter 3 patients survived.
  
  
  CONCLUSIONS
  We observed 5 patients with E. faecalis endocarditis as a late and severe sequela of SDD during their ICU stay.
authors.affiliation: Department of Internal Medicine, Westeinde Hospital, The Hague, The Netherlands.
authors.forename: Y W
authors.initials: YW
authors.lastname: Sijpkens
authors.forename: E J
authors.initials: EJ
authors.lastname: Buurke
authors.forename: C
authors.initials: C
authors.lastname: Ulrich
authors.forename: G J
authors.initials: GJ
authors.lastname: van Asselt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy*; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D013293:Enterococcus faecalis / Q000302:isolation & purification*; D004866:Equipment Contamination; D017809:Fatal Outcome; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission
chemical_list: D000900:Anti-Bacterial Agents