title: Esophageal aperistalsis and gastroesophageal reflux disorder: return of peristalsis after H2-blocker therapy.
abstract: OBJECTIVE
  Distal esophageal aperistalsis has rarely been reported among patients with gastroesophageal reflux disorder. The purpose of this study, therefore, was to address the frequency with which disorders of peristalsis in general--and distal esophageal aperistalsis in particular--occur in adults with gastroesophageal reflux disorder.
  
  
  METHODS
  We studied 314 patients who were referred to our gastrointestinal motility laboratory. On the basis of the endoscopic data, they were divided into three groups: group I, symptomatic patients without endoscopic esophagitis; group II, patients with mild endoscopic esophagitis; and group III, patients with erosive esophagitis. An age-matched group of patients with chest pain unrelated to reflux served as the control.
  
  
  RESULTS
  Some form of peristaltic dysfunction was recorded in 56% of the patients with gastroesophageal reflux disorder, significantly more than in the control group (p < 0.01). A significant correlation existed between the esophageal motor dysfunction scores and the severity of reflux disease. Distal esophageal aperistalsis was present in 3.1% of the reflux groups. There was a correlation between severity of reflux disease and the prevalence of aperistalsis. Aperistalsis occurred in none of the patients in group I, in 3.6% of group II, and in 12.5% of group III (p < 0.0001). Seven of the patients with aperistalsis who has been treated with H2-blockers were reexamined 4 months later. Return of peristalsis was seen in three of them.
  
  
  CONCLUSIONS
  Esophageal aperistalsis can be seen in a minority of patients with severe gastroesophageal reflux disorder and is probably a reversible condition.
authors.affiliation: Department of Medicine, University of California, Irvine, USA.
authors.forename: H
authors.initials: H
authors.lastname: Meshkinpour
mesh_terms: D004942:Esophagitis, Peptic / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010528:Peristalsis / Q000187:drug effects; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D011899:Ranitidine