Arf proteins: the membrane traffic police?
Cofactor for cholera toxin; activator of phospholipase D; regulator of coat-protein assembly; inhibitor of membrane traffic; ability to cause expansion of the endoplasmic reticulum and vesiculation of the Golgi; sensitivity to membrane phospholipids--each of these activities has been attributed to Arf proteins. Can a single molecular mechanism link them all?
Boman
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Laboratory of Biological Chemistry, Developmental Therapeutics Program, DCT, NCI, Bethesda, MD 20892, USA.
Kahn
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RA
D020727:ADP-Ribosylation Factors; D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D010743:Phospholipids / Q000378:metabolism
D008563:Membrane Lipids; D010743:Phospholipids; D019204:GTP-Binding Proteins; D020727:ADP-Ribosylation Factors