Structure-function interrelation and clinical effect of atrial natriuretic peptide (ANP).
Atriopeptin III (AP III) and its six analogues were synthesized by solid phase method and their diuretic and hypotensive activities were determined. Among these analogues, analogue [D-Ala-5, D-Arg-23] AP III was nearly 10 times as potent as AP III in diuretic activity while its hypotensive activity increased only 50% of that of AP III. Analogue des [Ser-15Gly-16Leu-17Gly-18Asn-20Ser-21] AP III was 15% as potent as AP III in diuretic activity, but it still maintained about 60% of the hypotensive activity of AP III. Meanwhile, we tried analogue [D-Ala-5, D-Agr-23] AP III for the treatment of hypertensive syndrome in pregnancy and obtained some good results.
Wang
J
J
Shanghai Institute of Biochemistry, Academia Sinica.
Shi
P
P
D000328:Adult; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004232:Diuretics / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008968:Molecular Conformation; D010446:Peptide Fragments; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D004232:Diuretics; D010446:Peptide Fragments; C062525:atrial natriuretic factor prohormone (103-126); D009320:Atrial Natriuretic Factor