Unilateral grafting of fetal neocortex into a cortical cavity improves healing of a symmetric lesion in the contralateral cortex of adult rats.
Fetal neocortical tissue (ED 14) was grafted unilaterally into a cortical cavity made bilaterally in the sensorimotor cortex of adult rats. Transplantation was done immediately after the lesion (group TR0, n = 8) or with 14-day delay (group TR14, n = 8). Six rats served as lesion only controls (group LES). After long-term survival (up to 15 months) the brains were photographed and surface areas of transplant and contralateral cavities were measured by means of a graphic tablet. The results show that (a) the presence of a transplant in one lesion cavity in the cortex decrease the size of a similar cavity in the contralateral cortex and that (b) the better host transplant integration there is, the greater the effect on the contralateral lesion. No correlation between the size of the transplant and the size of the symmetric traumatic lesion was found. The ameliorating effect of the transplant on the contralateral cortical lesion size is most likely related the long-term influence of growth of trophic factors released by transplanted cells which lead to the healing of the symmetric lesion.
Valousková
V
V
Institute of Physiology, Czech Academy of Sciences, Prague.
Gálik
J
J
D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D002540:Cerebral Cortex / Q000293:injuries* / Q000502:physiology* / Q000503:physiopathology; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D051381:Rats