Nicotine chewing gum and nicotine patch.
The nicotine gum is a flexible dosing form that allows for self-titration of nicotine. In order to secure adequate use instructions and guidance are necessary. The patches are fixed dose systems with no possibility to adjust dose, generally or momentarily. Because of its convenience to use, patch may be the first choice in a general practice setting while gum may prove more effective in a cessation clinic setting where more time and experience is available. Using both patch and gum in combination a certain base level of nicotine is established with patch, often insufficient in itself, but with adding of gum the desire for smoking will be better controlled.
Fagerström
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KO
Pharmacia Forschungsabteilung, Helsingborg, Sweden.
Tönnesen
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D000279:Administration, Cutaneous; D002638:Chewing Gum; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008134:Long-Term Care; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D012907:Smoking / Q000009:adverse effects*; D016540:Smoking Cessation / Q000379:methods*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D002638:Chewing Gum; D009538:Nicotine