title: Fetal pleural effusion: the risk of fetal trisomy.
abstract: Our objective was to review the association between fetal pleural effusion (FPE) and fetal aneuploidy. We conducted a retrospective survey of pregnant women who presented to our ultrasonographic unit between 1990 and 1991, and in whom the diagnosis of FPE was reached. All fetuses had karyotype investigation and a complete ultrasonographic search for associated anomalies. Six cases of FPE were identified. Trisomy 21 was found in 2 (33%). The English literature was reviewed and an additional 147 cases with FPE were collected, among them 6 cases of trisomy 21 and 1 of monosomy 45X. In this accumulated series the risk of aneuploidy in a fetus with an incidental finding of FPE was 5.8% (9 of 153), thus warranting a karyotype study.
authors.affiliation: Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Achiron
authors.forename: A
authors.initials: A
authors.lastname: Weissman
authors.forename: S
authors.initials: S
authors.lastname: Lipitz
authors.forename: S
authors.initials: S
authors.lastname: Mashiach
authors.forename: B
authors.initials: B
authors.lastname: Goldman
mesh_terms: D000328:Adult; D004314:Down Syndrome; D005260:Female; D005315:Fetal Diseases; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D009006:Monosomy; D010996:Pleural Effusion / Q000000981:diagnostic imaging / Q000196:embryology* / Q000235:genetics; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D016216:Ultrasonography, Prenatal