Cisplatin and carboplatin-mediated activation of murine peritoneal macrophages in vitro: production of interleukin-1 alpha and tumor necrosis factor-alpha.
Analysis of tissue culture supernatants collected from cisplatin (10 micrograms/ml) and carboplatin (50 micrograms/ml)-treated macrophages show enhanced activity of interleukin-1 alpha and tumor necrosis factor-alpha. Cytotoxicity of these supernatants was demonstrated using mouse sarcoma-180 cells. These results demonstrate the ability of cisplatin and carboplatin to enhance the immune system suggestive of yet another mechanism of their action in the regression of tumors.
Palma
J P
JP
Department of Zoology, Michigan State University, East Lansing 48824-1115, USA.
Aggarwal
S K
SK
D000818:Animals; D016190:Carboplatin / Q000494:pharmacology*; D002478:Cells, Cultured; D002945:Cisplatin / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis*; D008262:Macrophage Activation / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D016190:Carboplatin; D002945:Cisplatin