title: [Relationship between levels of aspartate aminotransferase in gingival crevicular fluid and periodontal disease activity].
abstract: This paper describes a longitudinal study in which clinical parameters and aspartate aminotransferase (AST) in gingival crevicular fluid (GCF) were monitored bimonthly over a 6-12 months period in 970 sites from 7 treated periodontitis patients. In this study, 21 out of 970 sites exhibited new attachment loss (AL) of at least 2mm between two consecutive visits. The GCF-AST levels and clinical parameters at sites with active tissue destruction (> or = 2mm AL within two months) were significantly higher than those at control sites on the same tooth. The GCF-AST levels and clinical parameters at sites with active tissue destruction decreased significantly after re-treatment. The measurement of GCF-AST could be an useful adjunctive criterion for detection of disease activity. However, it seems to be unsatisfactory in predicting disease activity.
authors.affiliation: School of Stomatology, Beijing Medical University.
authors.forename: F
authors.initials: F
authors.lastname: Yan
authors.forename: C
authors.initials: C
authors.lastname: Cao
authors.forename: X
authors.initials: X
authors.lastname: Li
mesh_terms: D001219:Aspartate Aminotransferases / Q000378:metabolism*; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D006801:Humans; D008137:Longitudinal Studies; D017622:Periodontal Attachment Loss / Q000201:enzymology; D010518:Periodontitis / Q000188:drug therapy / Q000201:enzymology*; D015572:Spiramycin / Q000627:therapeutic use
chemical_list: D015572:Spiramycin; D001219:Aspartate Aminotransferases