[The effect of antidote preparations on the immune reactions in acute dimethyl dichlorovinyl phosphate poisoning].
Experiments on CBA mice established that acute intoxication with dimethylchlorovinyl phosphate given in a single LD50 of 1.0 increased mice splenic colony-forming cells, decreased thymic T cells, delayed hypersensitivity, natural and antibody-dependent cellular cytotoxicities, sheep splenic red blood cells, thymus-independent Vi antigen antibody production. The antidote therapy with atropine (20 mg/kg) did not stop the main manifestations of posttoxication immunodeficiency and enhanced the suppression of a humoral immune response to sheep red blood cells. Dipyroxim (15 mg/kg) diminished manifestations of postintoxication immunodeficiency.
Zabrodskiĭ
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D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000931:Antidotes / Q000627:therapeutic use*; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D001285:Atropine / Q000627:therapeutic use; D004006:Dichlorvos / Q000506:poisoning*; D004353:Drug Evaluation, Preclinical; D007111:Immunity, Cellular / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D011041:Poisoning / Q000188:drug therapy / Q000276:immunology; D014289:Trimedoxime / Q000627:therapeutic use
D000931:Antidotes; D014289:Trimedoxime; D001285:Atropine; D004006:Dichlorvos
Vliianie antidotnykh preparatov na immunnye reaktsii pri ostroĭ intoksikatsii dimetildikhlorvinilfosfatom.