In vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent.
This study evaluated the in vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent. The drug inhibited all tested members of the family Enterobacteriaceae at < or = 0.5 microgram/ml and all tested Pseudomonas aeruginosa, Burkholderia (Pseudomonas) cepacia, and Xanthomonas maltophilia strains at < or = 2 micrograms/ml. All but two strains of gram-positive bacteria were inhibited by < or = 1 microgram of the new drug per ml, including isolates highly resistant to ciprofloxacin.
Eliopoulos
G M
GM
Department of Medicine, Deaconess Hospital, Boston, Massachusetts 02215, USA.
Wennersten
C B
CB
Cole
G
G
Chu
D
D
Pizzuti
D
D
Moellering
R C
RC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000494:pharmacology*; D011807:Quinolizines / Q000494:pharmacology*
C094159:A 86719.1; D000900:Anti-Bacterial Agents; D011728:Pyridones; D011807:Quinolizines