[Macrophage cell cycle control by M-CSF/CSF-1].
Temporally orderly activation of the cyclin-dependent kinases (cdks) governs the progression and the transitions of the cell cycle in mammalian cells. Macrophages require a specific growth factor, M-CSF/CSF-1, for their proliferation throughout the G1 phase of the cell cycle. Once cells enter S phase, macrophages complete mitosis in the absence of M-CSF/CSF-1. During the G1 phase, cyclin D1 is induced by M-CSF/CSF-1 stimulation and forms enzymatically active complex with cdk 4. The enzymatic activity of the cyclin D1 and cdk 4 complex could be negatively regulated by recently reported inhibitory proteins to determine the timing for entry into S phase in macrophages.
Matsushime
H
H
Department of Genetics Institute of Medical Science, University of Tokyo.
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D019938:Cyclin D1; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology*; D008264:Macrophages / Q000166:cytology*; D015513:Oncogene Proteins / Q000378:metabolism
D016213:Cyclins; D015513:Oncogene Proteins; D019938:Cyclin D1; D016173:Macrophage Colony-Stimulating Factor; D018844:Cyclin-Dependent Kinases