title: [General principles of choice of antibiotics for antibiotic prophylaxis in surgery].
abstract: A large amount of knowledge has been obtained in the field of prophylactic antibiotics over the past few years. Only procedures with a reasonable risk (incidence or severity) ought to be covered. Antibiotics must be present not only in plasma but also in the tissues during the surgical procedure. In most cases a very short prophylaxis, usually using a single bolus, is convenient. The best cost/benefit ratio has to be obtained. Several points remain unclear and require further investigations: what is the best dosage? What is the adequate timing for reinjections according to the duration of surgical procedure, and to the risk of postoperative infection using a "risk index"? Must we modulate the type of prophylaxis according to the duration of hospital stay before surgery? What is the value of selective decontamination of the digestive tract?
authors.affiliation: Service de Réanimation-Polyvalente, Hôpital Saint-Joseph, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Carlet
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Principes généraux du choix d'un antibiotique pour l'antibioprophylaxie en chirurgie.