Genomic organization of human histo-blood group ABO genes.
We have isolated human genomic DNA clones encompassing 30 kbp of the histo-blood group ABO locus. The locations of the exons have been mapped and the nucleotide sequences of the exon-intron boundaries have been determined. The human ABO genes consist of at least seven exons, and the coding sequence in the seven coding exons spans over 18 kb of the genomic DNA. The exons range in size from 28 to 688 bp, with most of the coding sequence lying in exon 7.
Yamamoto
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F
Department of Molecular Biology, Biomembrane Institute, Seattle, WA 98119, USA.
McNeill
P D
PD
Hakomori
S
S
D000017:ABO Blood-Group System / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005091:Exons; D005700:Galactosyltransferases / Q000235:genetics; D015698:Genomic Library; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D012326:RNA Splicing; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D000017:ABO Blood-Group System; D017931:DNA Primers; D005700:Galactosyltransferases; C037959:beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase