Quantitative mapping of ocular oxygenation using magnetic resonance imaging.
Retinal hypoxia is hypothesized to initiate angiogenesis, a leading cause of blindness in developed countries. Attempts to test this hypothesis suffer from the need to use highly invasive oxygen electrodes. In this communication, noninvasive and quantitative mapping of ocular oxygenation using magnetic resonance imaging is demonstrated for the first time.
Berkowitz
B A
BA
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-8592, USA.
Wilson
C A
CA
D000818:Animals; D002415:Cats; D015687:Cell Hypoxia / Q000502:physiology; D003930:Diabetic Retinopathy / Q000175:diagnosis; D005123:Eye / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010101:Oxygen Consumption; D011817:Rabbits; D015861:Retinal Neovascularization / Q000175:diagnosis; D012178:Retinopathy of Prematurity / Q000175:diagnosis; D012815:Signal Processing, Computer-Assisted