[A comparative assessment of the effect of different methods of glucocorticosteroid therapy on the hypophyseal-adrenal system in bronchial asthma patients].
As shown by morphofunctional examinations of hypophyseal-adrenal system in 137 BA patients and post mortem examinations of adrenal cortex in 72 BA cases, most pronounced defects in glucocorticosteroid (GCS) biosynthesis and metabolism were recorded in patients on long-term GCS regiments (5-10 years and more). They displayed low levels of 11-OCS and 17-OCS, enhanced transcortin binding capacity, diminished adrenocortical reserves. Beclometasone propionate, endobronchial liposomes with hydrocortisone had no negative adrenal effects.
Landyshev
Iu S
IuS
Grigorenko
A A
AA
Marikhina
N S
NS
Molochnaia
S V
SV
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000503:physiopathology; D014156:Transcortin / Q000032:analysis
D015062:11-Hydroxycorticosteroids; D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D014156:Transcortin; D006854:Hydrocortisone
Sravnitel'naia otsenka vliianiia razlichnykh metodov gliukokortikosteroidnoĭ terapii na gipofizarno-nadpochechnikovuiu sistemu u bol'nykh bronkhial'noĭ astmoĭ.