title: [Mechanisms of natural detoxication and antioxidant protection].
abstract: This paper considers the mechanisms of energy-dependent and synchronized detoxication and antioxidative defense (AOD) when synchronized detoxication and antioxidative defense (AOD) when the body is exposed to chemicals. It emphasizes the role of glutathione as a binder of this system involving in the regulation of this activity. It also discusses the mechanisms that define the reliability and efficiency of detoxication and AOD. The paper discusses whether the body's resistance to technogenic toxicants can be enhanced by using metabolic precursors of glutathione and other natural and (or) synthetic agents activating natural detoxication and AOD.
authors.forename: L A
authors.initials: LA
authors.lastname: Tiunov
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008658:Inactivation, Metabolic; D051379:Mice; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism; D013997:Time Factors; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004798:Enzymes; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione
vernacular_title: Mekhanizmy estestvennoĭ detoksikatsii i antioksidantnoĭ zashchity.