[Preoperative hypoxia-radiotherapy in multimodal treatment of patients with stage III colonic cancer].
The paper analyzes the results of surgical and multimodality therapies for 237 patients with Stage III colonic cancer, which were divided into 3 groups. Group 1 included 119 patients undergone only surgical management, Group 2 comprised 43 who were additionally treated with intensive radiation (4 Gy daily for 5 days) and Group 3 consisted of 75 patients who were irradiated in the presence of overall hypoxia evoked by breathing a gaseous mixture containing 9% oxygen. A five-year follow-up has indicated that there are significantly higher survival rates among those who have received a multimodality therapy rather than those merely operated on (82 +/- 5 and 53 +/- 9%, respectively). A short-term gaseous hypoxia has been found to reduce the incidence of systemic radiation reactions in patients during preoperative radiation and to fail to lower the efficiency of multimodality therapy.
Goldobenko
G V
GV
Prorokov
V V
VV
Knysh
V I
VI
Barkanov
A I
AI
D003110:Colonic Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D000860:Hypoxia; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D013997:Time Factors
Predoperatsionnaia gipoksiradioterapiia pri kombinirovannom lechenii bol'nykh rakom obodochnoĭ kishki III stadii.