title: Growth of the internal and external eye in term and preterm infants.
abstract: BACKGROUND
  Better knowledge of the growth patterns of the external and internal eyes of neonates would permit more accurate diagnosis of disorders that affect ocular size such as infantile glaucoma and microphthalmos. Such disorders preferentially may affect certain parts of the internal eye but not other parts. No previous study statistically has evaluated internal ocular growth in preterm newborns.
  
  
  METHODS
  A-scan ultrasonography was applied directly to the corneas of 101 healthy preterm and term newborns to determine axial length, anterior chamber depth, lens thickness, and vitreous chamber depth. The growth of these structures was evaluated by correlation and regression analyses.
  
  
  RESULTS
  At term, the mean measurements were axial length, 16.2 mm; anterior chamber depth, 2.0 mm; lens thickness, 3.8 mm; and vitreous chamber depth, 10.5 mm. Postconceptional age correlated to axial length (P < 0.001), anterior chamber depth (P = 0.032), and vitreous chamber depth (P < 0.001), but not to lens thickness (P = 0.48). By regression analysis, the eyes of males grew faster than those of females (P < 0.001) mainly due to the vitreous chamber.
  
  
  CONCLUSIONS
  In the last trimester and first 2 postnatal months, lens thickness remains constant, while the anterior chamber and, especially, the vitreous chamber deepen.
authors.affiliation: Jules Stein Eye Institute, Department of Ophthalmology, Harbor-UCLA Medical Center, UCLA School of Medicine, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Isenberg
authors.forename: D
authors.initials: D
authors.lastname: Neumann
authors.forename: P Y
authors.initials: PY
authors.lastname: Cheong
authors.forename: Y L
authors.initials: YL
authors.lastname: Ling
authors.forename: L C
authors.initials: LC
authors.lastname: McCall
authors.forename: A J
authors.initials: AJ
authors.lastname: Ziffer
mesh_terms: D000867:Anterior Chamber / Q000000981:diagnostic imaging / Q000254:growth & development*; D000886:Anthropometry; D001835:Body Weight; D036861:Delivery, Obstetric; D005123:Eye / Q000000981:diagnostic imaging / Q000254:growth & development*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000254:growth & development*; D007234:Infant, Premature / Q000254:growth & development*; D007908:Lens, Crystalline / Q000000981:diagnostic imaging / Q000254:growth & development*; D008297:Male; D011247:Pregnancy; D012044:Regression Analysis; D012727:Sex Characteristics; D014463:Ultrasonography; D014822:Vitreous Body / Q000000981:diagnostic imaging / Q000254:growth & development*