Sudden death in elderly women with Fabry's disease.
We report two cases of elderly women who died unexpectedly. In both cases, light- and electron-microscopical examination proved a diagnosis of Fabry's disease. The major pathological changes were myocardial mottling, foamy vacuolation of myocytes and glomerular endothelial cells, and characteristic lamellar inclusions. Neither woman had either a personal or family history of Fabry's disease. Fabry's disease presenting as sudden death is very rare. We present the findings in two cases together with a review of literature particularly relevant to the cardiovascular system.
Carter
N
N
Department of Forensic Pathology, University of Sheffield, England.
Milroy
C M
CM
Shepherd
R T
RT
D000368:Aged; D000369:Aged, 80 and over; D003645:Death, Sudden / Q000209:etiology*; D000795:Fabry Disease; D005260:Female; D006801:Humans; D008875:Middle Aged