title: [Adjuvant chemotherapy in the treatment of pharyngolaryngeal cancers in advanced stages].
abstract: Since 1980 we use adjuvant chemotherapy in advanced laryngopharyngeal carcinomas. These cases were resectable and unresectable lesions with tumoral extent to the pharynx as a common characteristic. We analyze the survival of the first 50 cases treated with chemotherapy followed by: A) surgery and radiotherapy (36 cases) and B) radiotherapy alone (14 cases). Results of this not randomized study are compared with a historic group of advanced laryngopharyngeal carcinomas (T4/N+) treated with conventional therapy (surgery +/- radiotherapy). Response to chemotherapy was complete or partial (> 50% reduction) in 56 percent of the patients. There was improvement in overall survival and five-years disease-free survival in the latter group compared with those who did show any response (p < 0.01). We would point out that disease-free survival of the group A was better than historic group (60% vs 36%, p < 0.05), although these result should be carefully interpreted. Laryngeal preservation was achieved in 47 percent in the group A by modification of the initially scheduled radical surgery, in selected cases.
authors.affiliation: Hospital Universitario 12 de Octubre, Madrid.
authors.forename: J J
authors.initials: JJ
authors.lastname: Alvarez Vicent
authors.forename: J A
authors.initials: JA
authors.lastname: Brandariz Castelo
authors.forename: C
authors.initials: C
authors.lastname: Domingo Carrasco
authors.forename: C
authors.initials: C
authors.lastname: Mendiola
authors.forename: J
authors.initials: J
authors.lastname: Guerrero
authors.forename: M
authors.initials: M
authors.lastname: Cornejo
mesh_terms: D002277:Carcinoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D007830:Larynx / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010610:Pharyngeal Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D010614:Pharynx / Q000473:pathology*; D011878:Radiotherapy
vernacular_title: Tratamiento quimioterápico adyuvante en carcinomas laringo-faríngeos en estadios avanzados.