Role of interleukin-6 in T-cell activation during primary and secondary infection with Listeria monocytogenes.
Injection of recombinant interleukin-6 (IL-6) into mice enhances recovery from infection with Listeria monocytogenes. In this study, the role of IL-6 during primary and secondary Listeria infection was further tested. Neutralization of IL-6 by polyclonal antibody exacerbated primary infection and significantly delayed gamma interferon production by cultured spleen cells. In contrast, administration of anti-IL-6 antibody at the time of secondary infection did not affect the recovery of mice from infection or gamma interferon production, showing that activated T cells are not dependent on IL-6.
Liu
Z
Z
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
Simpson
R J
RJ
Cheers
C
C
D000818:Animals; D005260:Female; D007156:Immunologic Memory; D015850:Interleukin-6 / Q000502:physiology*; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*
D015850:Interleukin-6