[Dynamic observation and significance of autoantibody against ADP/ATP carrier in dilated cardiomyopathy].
The presence and dynamic change of autoantibody against ADP/ATP carrier in patients with dilated cardiomyopathy (DCM) was studied by using indirect micro-solid-phase radioimmunoassay. A significant antibody titre was present in 16 of 48 DCM patients and most of them were in early stage of the disease. The titre of anti-ADP/ATP carrier antibody in DCM patients decreased gradually in a follow-up period of three months. The titre of this antibody in the serum from patients with coronary and rheumatic heart disease were within normal limits. Anti-ADP/ATP carrier antibody may play an important role in the pathogenesis, diagnosis and treatment of DCM.
Zhang
W
W
Department of Internal Medicine, First Affiliated Hospital, Xi'an Medical University.
Liu
Z
Z
Yang
D
D
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D016827:CD8 Antigens / Q000276:immunology; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D000226:Mitochondrial ADP, ATP Translocases / Q000276:immunology*; D011863:Radioimmunoassay
D001323:Autoantibodies; D016827:CD8 Antigens; D000226:Mitochondrial ADP, ATP Translocases