title: Canine eosinophilic folliculitis and furunculosis in three cases.
abstract: The historical, clinical and histopathological features of three dogs with eosinophilic folliculitis and furunculosis are described. The disease was characterised by the rapid development of pruritic, papular, pustular and ulcerative lesions on the dorsum of the muzzle. Skin lesions were confined to the face in two cases. The third dog had more generalised pustular lesions. Skin biopsy specimens showed marked eosinophil infiltration particularly centred on pilosebaceous units. Dermal collagen necrosis was evident in two cases. Similar facial lesions have previously been described as 'nasal pyoderma'. The three dogs failed to respond to initial antibacterial therapy but showed a rapid clinical response when prednisolone was given orally at doses ranging from 1 to 2.2 mg/kg, in addition to the antibacterial therapy, suggesting that glucocorticoids are indicated for the treatment of eosinophilic folliculitis and furunculosis. The aetiology of the disease was not determined.
authors.affiliation: Department of Small Animal Medicine and Surgery, Royal Veterinary College, Hatfield, Hertfordshire.
authors.forename: C F
authors.initials: CF
authors.lastname: Curtis
authors.forename: R
authors.initials: R
authors.lastname: Bond
authors.forename: A S
authors.initials: AS
authors.lastname: Blunden
authors.forename: D G
authors.initials: DG
authors.lastname: Thomson
authors.forename: P E
authors.initials: PE
authors.lastname: McNeil
authors.forename: T W
authors.initials: TW
authors.lastname: Whitbread
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D004802:Eosinophilia / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005499:Folliculitis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D005667:Furunculosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000473:pathology
chemical_list: D011239:Prednisolone