title: Genetic alterations in prostate adenocarcinoma.
abstract: The genetic alterations associated with prostate carcinogenesis, its progression, and the emergence of androgen independence gradually are being defined. This article focuses on a number of genetic defects that have been identified in prostate cancer, specifically as they relate to disease progression, radiation resistance, and androgen independence.
authors.affiliation: Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: N J
authors.initials: NJ
authors.lastname: Prendergast
authors.forename: P J
authors.initials: PJ
authors.lastname: Walther
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D018450:Disease Progression; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D008297:Male; D009857:Oncogenes / Q000235:genetics; D011230:Precancerous Conditions / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics*; D011836:Radiation Tolerance / Q000235:genetics; D011944:Receptors, Androgen / Q000235:genetics
chemical_list: D011944:Receptors, Androgen