Demonstration of the potassium channel opening activity of GYKI-12743 by 86Rb+ efflux studies.
It has been demonstrated that the novel antihypertensive compounds GYKI-12743 showed a potassium channel opening effect as studied in rabbit ear arteries with 86Rb+ as K+ marker. GYKI-12743 produced a concentration dependent 86Rb+ efflux in the same concentration range as the well-known K(+)-channel openers, pinacidil and cromakalim.
Bakonyi
A
A
Institute for Drug Research, Budapest, Hungary.
Horváth
E J
EJ
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001158:Arteries / Q000187:drug effects / Q000378:metabolism; D001578:Benzopyrans / Q000494:pharmacology; D019806:Cromakalim; D004146:Dioxanes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004423:Ear / Q000098:blood supply; D006146:Guanidines / Q000494:pharmacology; D015640:Ion Channel Gating / Q000187:drug effects; D020110:Pinacidil; D015221:Potassium Channels / Q000502:physiology*; D011724:Pyridazines / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology; D011817:Rabbits; D012414:Rubidium Radioisotopes
D000959:Antihypertensive Agents; D001578:Benzopyrans; D004146:Dioxanes; D006146:Guanidines; D015221:Potassium Channels; D011724:Pyridazines; D011758:Pyrroles; D012414:Rubidium Radioisotopes; D019806:Cromakalim; C064892:GYKI 12743; D020110:Pinacidil