Topical immunoglobulin is an effective therapy for parainfluenza type 3 in a cotton rat model.
A cotton rat model was used to test the efficacy of topical immunotherapy against parainfluenza type 3 (PIV3) infection. On day 3 after experimental infection with 10(5.5) pfu of PIV3, animals were treated with 2-fold dilutions of convalescent cotton rat serum or with one of two purified human immunoglobulin preparations; all three had moderate titers of anti-PIV3 neutralizing antibody (range, 1:200-1:1000). Therapy with high concentrations of all three preparations resulted in significant reductions of > or = 2 logs (> or = 100-fold) of pulmonary virus titers compared with titers for control animals. Little or no reduction in virus titers were seen in nasal tissues.
Ottolini
M G
MG
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Hemming
V G
VG
Piazza
F M
FM
Johnson
S A
SA
Darnell
M E
ME
Prince
G A
GA
D000287:Administration, Topical; D000818:Animals; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000627:therapeutic use; D008168:Lung / Q000821:virology; D009297:Nasal Mucosa / Q000821:virology; D010224:Parainfluenza Virus 3, Human / Q000302:isolation & purification; D018184:Paramyxoviridae Infections / Q000276:immunology / Q000628:therapy*; D016205:Sigmodontinae
D007136:Immunoglobulins