title: Recombinant tissue-type plasminogen activator therapy in prosthetic mitral valve thrombosis: assessment by transthoracic and transesophageal echocardiography.
abstract: Prosthetic cardiac thrombosis is a life-threatening complication that needs prompt diagnosis and therapy. We used recombinant tissue-type plasminogen activator (rT-PA), followed by heparin, in three patients with mitral prosthetic thrombosis, which was evident in two and suspect in one. Transthoracic and transesophageal echocardiography were employed in the diagnosis of both thrombosis and its resolution. No complications occurred. Immediately after the end of treatment with rT-PA, clinical status and echocardiographic data improved in all cases: transthoracic echocardiography showed the normalization of prosthetic function and transesophageal echocardiography showed resolution of thrombosis. One patient needed reoperation for rethrombosis due to the presence of prosthetic fibrous clot. rT-PA, followed by heparin, led to a good clinical result without bleeding and embolic complications in selected patients with mitral prosthetic thrombosis. Transthoracic and transesophageal echocardiography are complementary diagnostic tools in the diagnosis and management of patients with prosthetic thrombosis.
authors.affiliation: Department of Cardiology and Cardiac Surgery, Federico II University School of Medicine, Naples, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Losi
authors.forename: S
authors.initials: S
authors.lastname: Betocchi
authors.forename: C
authors.initials: C
authors.lastname: Briguori
authors.forename: F
authors.initials: F
authors.lastname: Manganelli
authors.forename: P P
authors.initials: PP
authors.lastname: Elia
authors.forename: N
authors.initials: N
authors.lastname: Spampinato
authors.forename: M
authors.initials: M
authors.lastname: Chiariello
mesh_terms: D000328:Adult; D000368:Aged; D015150:Echocardiography, Doppler; D017548:Echocardiography, Transesophageal; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D006493:Heparin; D010959:Tissue Plasminogen Activator