title: B cell activation, tolerance and antigen-presenting function.
abstract: Recent advances in the understanding of the collaboration between T cells and B cells have provided a novel framework within which to analyse the mechanisms of B-cell tolerance and its breakdown. Of particular interest has been the finding that B cell anergy is due to defective antigen receptor mediated functions, while the antigen-processing machinery and CD40-dependent activation pathways are unaffected. Thus, the anergic B cell, which otherwise has a short lifespan, can be rescued by a number of regimes to participate in autoimmune responses.
authors.affiliation: John Curtin School of Medical Research, Australian National University, ACT.
authors.forename: P D
authors.initials: PD
authors.lastname: Hodgkin
authors.forename: A
authors.initials: A
authors.lastname: Basten
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D017951:Antigen Presentation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008211:Lymphocyte Cooperation / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology