title: Free radicals and ocular disease.
abstract: Ames, Shigenaga, and Hagen recently published a thorough review of the relationship between oxidants, antioxidants, and degenerative diseases of ageing. They point out that only 9% of Americans daily consume the two fruits and three vegetables recommended by the National Cancer Institute and the National Research Council/National Academy of Science. In addition to antioxidants, these foodstuffs contain many essential micronutrients. To date, specific recommendations for antioxidant supplementation have not been made by any governmental agency or professional association. A number of clinical, basic, and epidemiological studies have implicated free radical induced lipid peroxidation in various ocular disorders. It would seem prudent that those persons at greatest risk for these disorders take some precautions, which could include sunglasses that filter ultraviolet light; hats that shield the eyes from direct sunlight; and the ingestion of fruits, vegetables, and antioxidants.
authors.affiliation: Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Anderson
authors.forename: F L
authors.initials: FL
authors.lastname: Kretzer
authors.forename: L M
authors.initials: LM
authors.lastname: Rapp
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use; D002386:Cataract / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D005128:Eye Diseases / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008027:Light / Q000009:adverse effects; D015227:Lipid Peroxidation; D008268:Macular Degeneration / Q000378:metabolism / Q000503:physiopathology; D012160:Retina / Q000473:pathology / Q000528:radiation effects; D012178:Retinopathy of Prematurity / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D014815:Vitamins