title: The effects of topical indomethacin and clobetasol propionate on post-cryotherapy inflammation.
abstract: The effects of topical indomethacin and clobetasol propionate on erythema and oedema following low-dose cryotherapy to normal skin were examined using a single-blind technique. Both agents significantly reduced erythema, but neither had a significant effect on oedema. A further, controlled, double-blind study comparing topical indomethacin and inert gel base was performed after cryotherapy to hand warts. In this study, topical indomethacin had no significant effect on post-cryotherapy oedema, erythema, pain or blister formation 48 and 96 h after treatment. Both potent topical steroids and cyclo-oxygenase inhibitors reduce erythema after low-dose cryotherapy. In clinical practice, there is no evidence that topical indomethacin significantly inhibits the inflammatory response to cryotherapy.
authors.affiliation: Department of Dermatology, Royal Infirmary, Edinburgh, U.K.
authors.forename: F
authors.initials: F
authors.lastname: Humphreys
authors.forename: J
authors.initials: J
authors.lastname: Spiro
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D002990:Clobetasol / Q000008:administration & dosage*; D017679:Cryotherapy; D003872:Dermatitis / Q000473:pathology / Q000517:prevention & control*; D004311:Double-Blind Method; D004487:Edema / Q000517:prevention & control; D004890:Erythema / Q000517:prevention & control; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D012885:Skinfold Thickness; D014860:Warts / Q000628:therapy
chemical_list: D002990:Clobetasol; D007213:Indomethacin