title: [Molecular mechanisms of the effects of sodium hypochlorite on thrombocytes and lipoproteins].
abstract: Hypochlorite seems to inhibit platelet aggregation in the platelet-rich plasma (PRP) by modifying fibrinogen receptors. The hypochlorite-inactivated isolated platelets are completely repaired by native plasma. Platelet aggregation in PRP is suppressed by hypochlorite by its direct interaction with cells and indirectly due to plasma modification. The indirect action of hypochlorite is a reversible reaction between the platelet active groups and the products of plasma modification. The reaction may involve sulphur-containing groups. The spin-probe method shows that hypochlorite penetrates into the lipid phase of human blood lipoproteins. It initiates lipid peroxidation and causes the disturbance of the lipid structure and the protein please.
authors.forename: V I
authors.initials: VI
authors.lastname: Sergienko
authors.forename: M A
authors.initials: MA
authors.lastname: Murina
authors.forename: O M
authors.initials: OM
authors.lastname: Panasenko
authors.forename: N N
authors.initials: NN
authors.lastname: Trunilina
authors.forename: S A
authors.initials: SA
authors.lastname: Evgina
authors.forename: R K
authors.initials: RK
authors.lastname: Aĭdyraliev
authors.forename: D I
authors.initials: DI
authors.lastname: Roshchupkin
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D005453:Fluorescence; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects*; D008954:Models, Biological; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010980:Platelet Membrane Glycoproteins / Q000187:drug effects; D011817:Rabbits; D012973:Sodium Hypochlorite / Q000494:pharmacology*; D013113:Spin Labels
chemical_list: D008074:Lipoproteins; D010975:Platelet Aggregation Inhibitors; D010980:Platelet Membrane Glycoproteins; D013113:Spin Labels; D012973:Sodium Hypochlorite
vernacular_title: Molekuliarnye mekhanizmy deĭstviia gipokhlorita natriia na trombotsity i lipoproteiny.