title: Determination of octanol-water partition coefficients by an HPLC method for anticonvulsant structure-activity studies.
abstract: Octanol-water partition coefficients have been measured and calculated for eight clinically relevant anticonvulsants. For some compounds, these are the first experimentally available log P values. For the remainder of the molecules, new values have been suggested. The utility of the micro shake-flask experimental method and the ALOGP calculational method in determining anticonvulsant log P values has been demonstrated.
authors.affiliation: Department of Chemistry, Queen's University, Kingston, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Henczi
authors.forename: J
authors.initials: J
authors.lastname: Nagy
authors.forename: D F
authors.initials: DF
authors.lastname: Weaver
mesh_terms: D020003:1-Octanol; D000927:Anticonvulsants / Q000737:chemistry* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D000442:Octanols; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D000442:Octanols; D020003:1-Octanol