title: High-flux dialysis membranes improve lipid profile in chronic hemodialysis patients.
abstract: In a controlled prospective trial, the effect of a switch from cellulose-based, low-flux dialysis membranes to polysulphone, high-flux membranes on lipid parameters was evaluated. Baseline values of lipid parameters were identical in the study group and the control group in which the dialysis membrane remained unchanged. After 6 wk, total triglyceride, very low-density lipoprotein (VLDL) triglyceride, and VLDL cholesterol decreased, respectively, 28 +/- 17 (P < 0.01), 38 +/- 17 (P < 0.01), and 24 +/- 21% (P < 0.05), and the proportion of total cholesterol that was high-density lipoprotein cholesterol increased from 15 +/- 5 to 18 +/- 5% (P < 0.05) in the high-flux polysulphone group, whereas these variables remained unchanged in the control group. Low-density lipoprotein and total cholesterol as well as Kt/V, protein catabolic rate, parathyroid hormone, albumin, and body weight did not change. No change in lipoprotein lipase activity was found. In a second study, the effects of a single hemodialysis session with high-flux polysulphone and low-flux, cellulose-based membranes on lipid parameters and lipolytic activity were compared in a cross-over fashion. Treatment with both membranes resulted in a significant decrease in plasma triglyceride, VLDL triglyceride, and VLDL cholesterol. Lipoprotein lipase activity increased during hemodialysis. Changes in lipid parameters and lipolytic activity were identical during the two treatments.
authors.affiliation: Department of Nephrology, University Hospital, Utrecht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Blankestijn
authors.forename: P F
authors.initials: PF
authors.lastname: Vos
authors.forename: T J
authors.initials: TJ
authors.lastname: Rabelink
authors.forename: H J
authors.initials: HJ
authors.lastname: van Rijn
authors.forename: H
authors.initials: H
authors.lastname: Jansen
authors.forename: H A
authors.initials: HA
authors.lastname: Koomans
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002482:Cellulose / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000628:therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D011446:Prospective Studies; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones; D013997:Time Factors
chemical_list: D008055:Lipids; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D002482:Cellulose; C009865:cuprammonium cellulose