[Persistent discrepancy between FDP and D-dimer in a patient with acute leukemia].
In a patient with acute myeloblastic leukemia, serum fibrinogen/fibrin degradation products (FDP) were markedly elevated to 54.91 micrograms/ml, but plasma D-dimer was only slightly elevated (1.44 micrograms/ml). FDP in plasma measured by a method using monoclonal antibody specific to FDP was less than 5 micrograms/ml. Gradual reduction of blastic cells was obtained with the therapy of low-dose cytarabine, G-CSF and etoposide. The serum FDP increased up to 71.74 micrograms/ml accompanied with a transient elevation of D-dimer, and subsequently declined without any anticoagulant therapy. However, a discrepancy between serum FDP and plasma D-dimer lasted for a long time. In this case persistent acceleration of coagulation and fibrinolysis which may result in the elevation of serum FDP was not observed, suggesting that the greater part of increased FDP didn't reflect the true FDP formed by plasmin. There were possibilities that elevated serum FDP values were also caused by the presence of soluble fibrin, unclottable fibrinogen and the degradation products by nonplasmic proteinases. Simultaneous measurements of FDP and D-dimer are useful for a more accurate evaluation of hyperfibrinolytic states and to avoid possible misinterpretations due to falsely positive FDP.
Sato
N
N
First Department of Internal Medicine, Niigata University School of Medicine.
Takahashi
H
H
Nikuni
K
K
Seki
Y
Y
Wada
K
K
Tatewaki
W
W
Shibata
A
A
D000368:Aged; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008297:Male
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D