Molecular genetics of neuronal survival.
The past year has witnessed remarkable progress towards understanding the molecular genetics of neuronal survival. Gene-targeting experiments in mice have confirmed the long-standing idea that the nerve growth factor model of neuronal survival--that is, neuronal dependence on target-derived molecules during a critical period in development--is broadly applicable. Furthermore, a variety of biochemical and genetic techniques applied to both mammals and invertebrates have identified new genes involved in regulating cell survival during development.
Silos-Santiago
I
I
Washington University School of Medicine, St Louis, USA.
Greenlund
L J
LJ
Johnson
E M
EM
Snider
W D
WD
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor; D002453:Cell Cycle / Q000502:physiology; D002470:Cell Survival / Q000235:genetics*; D005796:Genes; D051379:Mice; D009414:Nerve Growth Factors / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors