title: Systemic lupus erythematosus, rheumatoid arthritis and HLA phenotypes in Jamaicans.
abstract: The HLA phenotypes were investigated in 30 Jamaican patients with Systemic Lupus Erythematosus (SLE), 30 with Rheumatoid Arthritis (RA) and 40 healthy controls. HLA phenotypes were determined by the microcytoxicity technique, using commercially prepared typing trays. In this study, the HLA phenotypic associations with SLE (HLA-B14, RR 4.3: HLA-A28, RR 4.3) were not statistically significant. However, a statistically significant lack of HLA-A9 (p < 0.01; CP < 0.1) was observed in SLE patients compared to healthy controls. In RA patients, a statistically significant association was noted with HLA-A2 (RR 5.1; CP < 0.01). No HLA class II associations were noted with SLE. Class II associations with RA did not achieve statistical significance but included those previously established in other populations. The preliminary data obtained from this study indicate differences in the patterns of HLA phenotypes in Jamaican patients with SLE and RA compared to those observed in such patients elsewhere. Further studies involving larger groups of patients and typing at the serological, cellular and molecular levels are clearly warranted.
authors.affiliation: Department of Microbiology, U.W.I., Jamaica.
authors.forename: M F
authors.initials: MF
authors.lastname: Smikle
authors.forename: E N
authors.initials: EN
authors.lastname: Barton
authors.forename: K
authors.initials: K
authors.lastname: DeCeulaer
authors.forename: W N
authors.initials: WN
authors.lastname: Williams
authors.forename: O B
authors.initials: OB
authors.lastname: James
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007563:Jamaica; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D010641:Phenotype; D012306:Risk
chemical_list: D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II