title: Progressive pulmonary cryptococcosis in a patient who is immunocompetent.
abstract: Pulmonary cryptococcal disease can have variable clinical and roentgenographic presentations. Symptoms and radiographic abnormalities can resolve prior to therapy, even in a patient who is immunocompromised. Antifungal therapy is generally not recommended for a patient who is immunocompetent with nonprogressive, nondisseminated pulmonary cryptococcosis. We present a case of pulmonary cryptococcosis that progressed despite fluconazole therapy in a patient who was immunocompetent. This appears to be the second reported case of a discrete endobronchial cryptococcoma.
authors.affiliation: Department of Internal Medicine, National Naval Medical Center, Bethesda, Md. 20889-5600, USA.
authors.forename: W W
authors.initials: WW
authors.lastname: Emmons
authors.forename: S
authors.initials: S
authors.lastname: Luchsinger
authors.forename: L
authors.initials: L
authors.lastname: Miller
mesh_terms: D003453:Cryptococcosis / Q000188:drug therapy / Q000503:physiopathology*; D018450:Disease Progression; D015725:Fluconazole / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007121:Immunocompetence; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008477:Mediastinal Diseases / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology; D008875:Middle Aged
chemical_list: D015725:Fluconazole