title: Lack of sensitivity of indium-111 mixed leukocyte scans for active disease in Takayasu's arteritis.
abstract: OBJECTIVE
  Currently, a reliable, noninvasive means of detecting the active vasculitic lesions of Takayasu's arteritis does not exist. Based on the cellular infiltrates seen in active lesions, we postulated that indium-111 labelled mixed leukocytes could be used to scintigraphically detect sites of active vasculitis.
  
  
  METHODS
  Fifteen In-111 mixed leukocyte scans were performed in 10 patients with Takayasu's arteritis and correlated with clinical, laboratory, and radiographic findings. Patients had either active, stable/smoldering, or inactive disease at the time when 8, 4, and 3 scans were performed, respectively.
  
  
  RESULTS
  Two of the 8 scans performed in patients with active disease were positive for increased vessel uptake (sensitivity = 25%). All other scans were interpreted as negative for active arteritis.
  
  
  CONCLUSIONS
  We conclude that In-111 mixed leukocyte scans have a low sensitivity for detection of active Takayasu's arteritis.
authors.affiliation: Department of Nuclear Medicine, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: G S
authors.initials: GS
authors.lastname: Kerr
authors.forename: C S
authors.initials: CS
authors.lastname: Carter
authors.forename: E J
authors.initials: EJ
authors.lastname: Read
authors.forename: J A
authors.initials: JA
authors.lastname: Carrasquillo
authors.forename: S F
authors.initials: SF
authors.lastname: Leitman
authors.forename: G S
authors.initials: GS
authors.lastname: Hoffman
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013625:Takayasu Arteritis / Q000000981:diagnostic imaging*
chemical_list: D007205:Indium Radioisotopes