title: Relationship of infant feeding to recurrent wheezing at age 6 years.
abstract: OBJECTIVE
  To investigate the relationship of infant feeding to recurrent wheezing at age 6 years and to assess whether this relationship is altered by a history of wheezing lower respiratory tract illnesses.
  
  
  METHODS
  Prospective, longitudinal study of healthy infants followed up from birth to 6 years of age.
  
  
  METHODS
  Nonselected health maintenance organization population in Tucson, Arizona.
  
  
  METHODS
  There were 1246 healthy infants enrolled at birth, 988 of whom had data on both infant feeding and wheezing at age 6 years.
  
  
  METHODS
  None.
  
  
  METHODS
  Recurrent wheeze (four or more episodes in the past year) was assessed by a questionnaire that was completed by parents when the children were 6 years old. Children were classified by atopic status on the basis of skin prick tests.
  
  
  RESULTS
  Breast-feeding information was collected prospectively, and lower respiratory tract illnesses in the first 3 years of life were diagnosed by the pediatrician. Being breast-fed was associated with lower rates of recurrent wheeze at age 6 years (3.1% vs 9.7%, P < .01) for nonatopic children; this relationship was not significant for atopic children. The relationship of breast-feeding with recurrent wheeze was apparent among nonatopic children both with and without a wheezing lower respiratory tract illness in the first 6 months of life. When potential confounders, including early wheezing lower respiratory tract illness, were included in a multivariate model, nonatopic children who had not been breast-fed had three times the odds of wheezing recurrently (odds ratio, 3.03; confidence interval, 1.06 to 8.69). Eleven percent of recurrent wheeze among nonatopic children could be attributed to not breast-feeding.
  
  
  CONCLUSIONS
  Recurrent wheeze at age 6 years is less common among nonatopic children who were breast-fed as infants. This effect is independent of whether the child wheezed with a lower respiratory tract illness in the first 6 months of life.
authors.affiliation: Department of Pediatrics, University of Arizona, Tucson, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Wright
authors.forename: C J
authors.initials: CJ
authors.lastname: Holberg
authors.forename: L M
authors.initials: LM
authors.lastname: Taussig
authors.forename: F D
authors.initials: FD
authors.lastname: Martinez
mesh_terms: D001942:Breast Feeding; D002648:Child; D005260:Female; D006801:Humans; D006967:Hypersensitivity; D007231:Infant, Newborn; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012008:Recurrence; D012135:Respiratory Sounds; D012141:Respiratory Tract Infections / Q000453:epidemiology; D012307:Risk Factors