[Neuropathology of non conventional infectious agents or prions].
The neuropathological diagnosis of infections by non conventional agents relies on four lesions: astrocytic gliosis (cell hypertrophy and proliferation) usually contrasting with absent mononuclear cell infiltrates (lymphocytes, monocytes-macrophages, and/or microglia) revealed by conventional techniques, and neuronal loss in the most affected areas are little specific findings. Amyloid plaques that are inconstantly found, and spongiosis of gray matter, a characteristic and very frequent finding, are most specific. PrP immunohistochemistry brings additional data. The main diagnostic difficulties are emphasized, and guidelines for Pathological studies are recalled.
Hauw
J J
JJ
Laboratoire de Neuropathologie R. Escourolle, Hôpital de la Salpêtrière, Université Paris VI, INSERM U 360, Association Claude Bernard, France.
Naccache
P Y
PY
Seilhean
D
D
Camilleri
S
S
Mokhtari
K
K
Duyckaerts
C
C
D000818:Animals; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis* / Q000473:pathology; D016098:Gerstmann-Straussler-Scheinker Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007729:Kuru / Q000175:diagnosis* / Q000473:pathology; D017096:Prion Diseases / Q000175:diagnosis* / Q000473:pathology
Neuropathologie des agents infectieux non conventionnels ou prions.