title: Evaluation of serum type III procollagen peptide as an exposure marker in retired coal workers.
abstract: Serum type III procollagen peptide (PIIIP), a degradation product of the type III collagen precursor, has been put forward as an exposure marker for mineral dust. We evaluated PIIIP levels as a marker of exposure to and effects of coal dust in retired coal miners (n = 104). To this end: (a) the individual cumulative dust exposure was calculated from job-exposure matrices, and (b) in addition to routine chest radiography (CR) of all miners according to the criteria of the International Labour Organisation (ILO), a subgroup (n = 46) was screened by high-resolution computed tomography (HRCT). Profusion score (CR and HRCT) tended to increase with cumulative dust exposure, even in the absence of CR evidence for pneumoconiosis (i.e. CR < or = 0/1, n = 35). In contrast to our previous findings in active miners, PIIIP levels were not increased in miners as compared with non-dust-exposed controls (n = 29), and no differences were observed between miners without (ILO = 0/0) and miners with coal workers' pneumoconiosis (CWP; ILO > or = 0/1). No trend in PIIIP versus pneumoconiosis stage was present, either by CR or by the more sensitive HRCT score. PIIIP was also unrelated to any lung function parameter (FEV1, FVC, impedance, diffusion capacity). Age, medication, medical history and smoking habits had no significant effect on PIIIP levels. In the miners with CWP (i.e. ILO > 0/0, n = 28) a significant negative correlation was present between PIIIP values and (log) cumulative dust exposure. This decrease in serum PIIIP levels with increasing cumulative exposure may be due to chronic adaptive changes in type III collagen deposition and/or breakdown. Other relations between exposure and PIIIP were not observed. In conclusion, the present findings do not support the use of serum type III procollagen peptide as a marker of exposure to and (early) interstitial or respiratory effects of coal dust.
authors.affiliation: Department of Health Risk Analysis and Toxicology, University of Limburg, Maastricht, The Netherlands.
authors.forename: R P
authors.initials: RP
authors.lastname: Schins
authors.forename: R J
authors.initials: RJ
authors.lastname: Lamers
authors.forename: B
authors.initials: B
authors.lastname: Préat
authors.forename: P J
authors.initials: PJ
authors.lastname: Borm
mesh_terms: D003032:Coal Mining; D015331:Cohort Studies; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis*; D010446:Peptide Fragments / Q000097:blood*; D011009:Pneumoconiosis / Q000000981:diagnostic imaging; D011347:Procollagen / Q000097:blood*; D011859:Radiography; D012179:Retirement; D013997:Time Factors
chemical_list: D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide