title: Decreased corneal complications after no-reflux, low-dose 5 fluorouracil subconjunctival injection following trabeculectomy.
abstract: In order to reduce corneal complications in 27 glaucomatous eyes that underwent trabeculectomy and postoperative subconjunctival injection of 5-fluorouracil we tried 1) a low-dose administration of 5-fluorouracil and 2) a modified subconjunctival injection technique. The mean total 5-fluorouracil dose was 18.0 +/- 6 mg. A life-table analysis showed a success rate, at 15 months, of 78% (+/- 7 S.E.). Four of the 27 eyes (13%) had corneal complications, limited to punctate keratopathy, with no corneal epithelial defects and/or abrasions. Our study shows that corneal complications decreased when the contact between 5-fluorouracil and the ocular surface was reduced.
authors.affiliation: University Eye Clinic, Genova, Italy.
authors.forename: C E
authors.initials: CE
authors.lastname: Traverso
authors.forename: M
authors.initials: M
authors.lastname: Facino
authors.forename: U
authors.initials: U
authors.lastname: Murialdo
authors.forename: M
authors.initials: M
authors.lastname: Corazza
authors.forename: E
authors.initials: E
authors.lastname: Gandolfo
authors.forename: G
authors.initials: G
authors.lastname: Calabria
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003228:Conjunctiva; D003316:Corneal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D005355:Fibrosis / Q000188:drug therapy; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007267:Injections; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced / Q000517:prevention & control*; D014130:Trabeculectomy
chemical_list: D005472:Fluorouracil