title: Viridans streptococcal bacteraemia in patients with neutropenia.
abstract: Viridans streptococcal bacteraemia is frequent in neutropenic patients. 25 neutropenic patients with viridans streptococcal bacteraemia were compared with 64 control patients. Exposure to repeated chemotherapy or cytarabine were independent risk-factors for streptococcal bacteraemia. The use of carboxyureidopenicillins and a stay in laminar-airflow rooms were protective. In a further cohort study of 49 patients, oral streptococci with the same ribotype as blood isolates were recovered from all 7 bacteraemic patients. The oral cavity is a portal of entry for viridans streptococci bacteraemia in neutropenic patients, especially after oral mucosal damage induced by repeated chemotherapy.
authors.affiliation: Laboratoire de Bactériologie A, Hôtel-Dieu, Nantes, France.
authors.forename: P
authors.initials: P
authors.lastname: Richard
authors.forename: G
authors.initials: G
authors.lastname: Amador Del Valle
authors.forename: P
authors.initials: P
authors.lastname: Moreau
authors.forename: N
authors.initials: N
authors.lastname: Milpied
authors.forename: M P
authors.initials: MP
authors.lastname: Felice
authors.forename: T
authors.initials: T
authors.lastname: Daeschler
authors.forename: J L
authors.initials: JL
authors.lastname: Harousseau
authors.forename: H
authors.initials: H
authors.lastname: Richet
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D016470:Bacteremia / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D016022:Case-Control Studies; D003561:Cytarabine / Q000009:adverse effects; D004780:Environment, Controlled; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology; D009503:Neutropenia / Q000150:complications*; D011446:Prospective Studies; D012307:Risk Factors; D012463:Saliva / Q000382:microbiology; D013290:Streptococcal Infections / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D013291:Streptococcus / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003561:Cytarabine