[Adaptation of renewal of rat liver proteins to dietary protein with low biological value].
The study of the dynamics of adaptation to the rations containing casein and wheat protein showed some accumulation of hepatic protein on days 4-9. Evaluation of 14C-Leucine and protein turnover from the kinetics of precursor elimination from the pool and that of incorporation into proteins, demonstrated that there were no significant differences in the rate of endogenous protein synthesis, and the higher protein levels are associated with the lower secretion of these export proteins from the liver. In another experiment after adaptation to the casein feed, the animals were fed a wheat protein-containing feed, there were no changes in protein levels, yet the rate of total liver protein turnover was significantly increased on day 5, as shown by massive label estimation and calculation using the modified equation. Adaptation to new rations is accompanied by the initial accumulation of protein in the liver tissue and the subsequent adaptation to proteins of low biological value may be related to increases in the turnover of blood proteins exported from liver tissue.
Mal'tsev
G Iu
GIu
Gapparov
M M
MM
D000222:Adaptation, Physiological; D000818:Animals; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage*; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration / Q000502:physiology*; D051381:Rats
D001798:Blood Proteins; D004044:Dietary Proteins; D007930:Leucine
Adaptatsiia obnovleniia belkov pecheni krys k pishchevomu belku s nizkoĭ biologicheskoĭ tsennost'iu.