title: Needle aspiration lung biopsy: reevaluation of the blood patch technique in an equine model.
abstract: OBJECTIVE
  To reexamine the blood patch technique in a laboratory model of lung biopsy free of confounding clinical variables.
  
  
  METHODS
  An equine model of lung biopsy was developed with an excised lobe connected to an insufflation bulb and pressure monitor. Patched and control unpatched punctures were made in the lung surface, and the pressure within the lung was raised to the maximum achievable. Whether air leakage from the puncture sites could be induced was determined and, if so, at what pressure it occurred.
  
  
  RESULTS
  At statistical analysis with the Kaplan-Meier test and the Cox proportional hazards regression model, the difference between failure of the patched and unpatched punctures was statistically significant (P < .0001).
  
  
  CONCLUSIONS
  The blood patch technique is effective in the laboratory setting and deserves reevaluation in a clinical series with updated biopsy techniques.
authors.affiliation: Department of Radiology, University of California Davis Medical Center, Sacramento 95817, USA.
authors.forename: E H
authors.initials: EH
authors.lastname: Moore
authors.forename: D K
authors.initials: DK
authors.lastname: Shelton
authors.forename: E R
authors.initials: ER
authors.lastname: Wisner
authors.forename: M L
authors.initials: ML
authors.lastname: Richardson
authors.forename: D M
authors.initials: DM
authors.lastname: Bishop
authors.forename: J M
authors.initials: JM
authors.lastname: Brock
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000379:methods*; D006736:Horses; D066298:In Vitro Techniques; D008168:Lung / Q000473:pathology*