Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat.
By using substance P receptor (SPR) immunofluorescence histochemistry combined with fluorescent retrograde labeling, SPR-like immunoreactive (SPR-LI) neurons sending their axons to the lateral parabrachial region were observed in the lumbar spinal cord of the rat. After injection of Fluoro-Gold into the lateral parabrachial region, retrogradely labeled neurons with SPR-LI were seen frequently in lamina I and the lateral spinal nucleus, and occasionally in laminae IV and V, with a predominantly contralateral distribution. Some of these neurons, especially those in lamina I, may convey nociceptive information to the lateral parabrachial region.
Ding
Y Q
YQ
Department of Morpholgoical Brain Science, Faculty of Medicine, Kyoto University, Japan.
Takada
M
M
Shigemoto
R
R
Mizumo
N
N
D000818:Animals; D007150:Immunohistochemistry; D008297:Male; D008856:Microscopy, Fluorescence; D009434:Neural Pathways / Q000378:metabolism; D009619:Nociceptors / Q000502:physiology; D011149:Pons / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
D018040:Receptors, Neurokinin-1