title: Effect of pinealectomy and melatonin treatment during pregnancy on the sexual development of the female and male rat offspring.
abstract: Sexual development of female and male rat offspring of control, pinealectomized (PIN-X) or melatonin (MEL 250 micrograms/100 g body wt)-treated mother rats during pregnancy was studied. Newborns were studied at the following phases of sexual development: neonate (5 days old), infantile (15 days old), juvenile (25 and 30 days old) and pubertal phase (55 days). In female offspring, MEL treatment during pregnancy significantly increased plasma luteinizing hormone (LH) in 15- and 25-day-old rats; however, at the end of the prepubertal period (30 days) the concentration of plasma LH decreased significantly as compared to control rats. This hormonal pattern was different from that observed in offspring of control and PIN-X rats, which had low LH levels at 25 days of age and higher LH levels at 30 days of age. Follicle-stimulating hormone (FSH) did not vary significantly among the three groups. Plasma prolactin levels were affected by PIN-X of the mother, showing significantly higher levels in the 5-day-old offspring than in the controls; plasma prolactin levels were also affected by MEL treatment of the mother, producing hyperprolactinemia in the 30-day-old female offspring. In male offspring, sexual development in control male rats progressed rapidly with significantly increased LH and FSH levels at 25 and 30 days compared to those measured during the neonatal and infantile periods.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Dpto. de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Díaz López
authors.forename: M D
authors.initials: MD
authors.lastname: Colmenero Urquijo
authors.forename: M E
authors.initials: ME
authors.lastname: Díaz Rodriguez
authors.forename: A
authors.initials: A
authors.lastname: Arce Fraguas
authors.forename: A
authors.initials: A
authors.lastname: Esquifino Parras
authors.forename: B
authors.initials: B
authors.lastname: Marín Fernández
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000196:embryology / Q000502:physiology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012733:Sex Differentiation / Q000187:drug effects* / Q000502:physiology; D012741:Sexual Maturation / Q000187:drug effects* / Q000502:physiology
chemical_list: D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008550:Melatonin