title: Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation.
abstract: Several fast-growing Mycobacterium strains were found to inactivate rifampin. Two inactivated compounds (RIP-Ma and RIP-Mb) produced by these organisms were different from previously reported derivatives, i.e., phosphorylated or glucosylated derivatives, of the antibiotic. The structures of RIP-Ma and RIP-Mb were determined to be those of 3-formyl-23-[O-(alpha-D-ribofuranosyl)]rifamycin SV and 23-[O-(alpha-D-ribofuranosyl)]rifampin, respectively. To our knowledge, this is the first known example of ribosylation as a mechanism of antibiotic inactivation.
authors.affiliation: Division of Experimental Chemotherapy, Chiba University, Japan.
authors.forename: E R
authors.initials: ER
authors.lastname: Dabbs
authors.forename: K
authors.initials: K
authors.lastname: Yazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: M
authors.initials: M
authors.lastname: Miyaji
authors.forename: N
authors.initials: N
authors.lastname: Morisaki
authors.forename: S
authors.initials: S
authors.lastname: Iwasaki
authors.forename: K
authors.initials: K
authors.lastname: Furihata
mesh_terms: D008658:Inactivation, Metabolic; D009161:Mycobacterium / Q000378:metabolism*; D012293:Rifampin / Q000378:metabolism*
chemical_list: D012293:Rifampin