title: Effect of bile obstruction on liver regeneration following major hepatectomy: an experimental study in the rat.
abstract: The regeneration of the liver following resection is regulated by a variety of factors and it might be expected that jaundice influences the process. We therefore evaluated the regenerative response to major hepatectomy in bile-obstructed rats. Two weeks after ligation of the common bile duct, a standardized 77% hepatectomy was undertaken. The jaundiced animals showed an augmented liver regeneration compared to nonjaundiced individuals (p < 0.01). However, blood clearance of radiolabelled Escherichia coli bacteria was impaired (p < 0.01) in animals with bile obstruction at 7 days after the hepatectomy, accompanied by reduced bacterial uptake in the liver as a sign of impaired reticuloendothelial system function.
authors.affiliation: Department of Surgery, National Hospital, Oslo University, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Foss
authors.forename: R
authors.initials: R
authors.lastname: Andersson
authors.forename: J W
authors.initials: JW
authors.lastname: Ding
authors.forename: P
authors.initials: P
authors.lastname: Hochbergs
authors.forename: J E
authors.initials: JE
authors.lastname: Paulsen
authors.forename: S
authors.initials: S
authors.lastname: Bengmark
authors.forename: B
authors.initials: B
authors.lastname: Ahrén
mesh_terms: D000818:Animals; D002779:Cholestasis / Q000503:physiopathology*; D006498:Hepatectomy; D008115:Liver Regeneration; D008297:Male; D012157:Mononuclear Phagocyte System / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley