Cephalosporin-induced recurrent aseptic meningitis.
A 66-year-old woman had several episodes of aseptic meningitis associated with exposure to cephalexin, cefazolin, and ceftazidime. The cerebrospinal fluid IgG index was elevated, specific IgG-ceftazidime binding was shown, and skin allergy testing with cefazolin provoked a recurrence of meningitis. We postulate an acute hypersensitivity reaction involving an antigen-specific humoral immune response.
Creel
G B
GB
Department of Neurology, University of Pittsburgh, PA, USA.
Hurtt
M
M
D000368:Aged; D002511:Cephalosporins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008582:Meningitis, Aseptic / Q000139:chemically induced* / Q000276:immunology; D012008:Recurrence
D002511:Cephalosporins; D007074:Immunoglobulin G