title: [Efficacy of oral administration of a micellaar solution of vitamin K during the neonatal period].
abstract: BACKGROUND
  Oral administration of vitamin K to neonates is quite satisfactory for preventing hemorrhagic disease of the newborn. The aim of this study is to test efficacy of a micellar solution of vitamin K at birth.
  
  
  METHODS
  Thirty full term infants, exclusively breast-fed during the first month of life, were included in this study. Seven of them (control group Cos) were given oral supplementation with 5 mg vitamin K1, cremophor; 15 other infants were given oral supplementation with 3 mg micellar solution of vitamin K1 (group MMos) and 7 were given an intramuscular injection of 1.5 mg micellar solution of vitamin K1 (group MMim). Prothrombin time activity and plasma vitamin K concentration were measured in the cord blood, 24 +/- 12 hours and 1 month after supplementation.
  
  
  RESULTS
  No hemorrhage was seen and tolerance to vitamin K was good in the 3 groups. Mean prothrombin time activity was 54% in the cord blood, around 55% and 75%, 24 hrs and 1 month after supplementation, respectively; only one infant had low value (41%) by 1 month despite normal plasma vitamin K concentration. Two infants had low plasma vitamin K1 concentration by the second control despite normal prothrombin time activity; one belonged to the MMos group and the other to the Cos group. Mean values of plasma vitamin K1 concentration were higher by 1 month in the MMos group.
  
  
  CONCLUSIONS
  A unique dose of micellar solution of vitamin K given orally at birth seems effective to prevent hemorrhagic disease.
authors.affiliation: Service de pédiatrie R-gastroentérologie et nutrition, hôpital Clocheville, CHU Tours, France.
authors.forename: C
authors.initials: C
authors.lastname: Maurage
authors.forename: C
authors.initials: C
authors.lastname: Dalloul
authors.forename: F
authors.initials: F
authors.lastname: Moussa
authors.forename: B
authors.initials: B
authors.lastname: Cara
authors.forename: D
authors.initials: D
authors.lastname: Dudragne
authors.forename: N
authors.initials: N
authors.lastname: Lion
authors.forename: O
authors.initials: O
authors.lastname: Amédée-Manesme
mesh_terms: D000284:Administration, Oral; D001942:Breast Feeding; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D008823:Micelles; D011516:Prothrombin / Q000032:analysis; D012996:Solutions; D014812:Vitamin K / Q000008:administration & dosage*; D010837:Vitamin K 1 / Q000008:administration & dosage* / Q000627:therapeutic use; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control
chemical_list: D008823:Micelles; D012996:Solutions; D014812:Vitamin K; D010837:Vitamin K 1; D011516:Prothrombin
vernacular_title: Efficacité de l'administration orale d'une solution micellaire de vitamine K en période néonatale.