Genetic analysis of susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease in the SWR strain.
SWR/J mice are susceptible to immune-mediated central (CNS) demyelination following infection by Theiler's murine encephalomyelitis virus (TMEV). SWR/J susceptibility is genetically dominant, when outcrossed to resistant H-2b strains. Non-H-2 differences between C57BL/6 and C57L/J (both H-2b) alter effects of 'susceptibility' genes, especially H-2q, from SWR/J. Genetic analysis of differential susceptibility to demyelination between SWR/J and C57L/J indicates that one copy of H-2q is sufficient for disease, and that SWR/J mice carry a non-H-2 gene which can lead to disease in the absence of H-2q. Differential susceptibility between SWR/J and C57BL/6 is determined by a single non-H-2 locus, which may or may not be the same as that differing between SWR/J and C57L/J.
Nicholson
S M
SM
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611, USA.
Jokinen
D M
DM
Canto
M C
MC
Kim
B S
BS
Melvold
R W
RW
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003711:Demyelinating Diseases / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D006183:H-2 Antigens / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011051:Poliomyelitis / Q000235:genetics*; D012737:Sex Factors
D006183:H-2 Antigens