title: [Prevalence of intra-auricular thrombi detected by transesophageal echocardiography in patients with cardiac transplants].
abstract: The aim of this study was to determine the prevalence of intra-atrial thrombi or spontaneous contrast by transoesophageal echocardiography in patients who underwent cardiac transplantation by Lower and Shumway's technique. Transoesophageal echocardiography was performed in 52 transplant patients (43 men, 9 women: average age 51 years) with a high frequency biplane transducer. After surgery, all patients received platelet antiaggregant therapy. Despite this treatment, 4 patients had a sudden systemic embolic episode and were then placed on oral anticoagulants. All patients were in sinus rhythm at the time of the examination and some had signs of acute rejection on endomyocardial biopsy performed the same day. Spontaneous contrast was observed in 27 patients (52%) and was associated with thrombosis in 15 patients (29%). These thrombi were located in the left atrial appendage in 8 cases, on the left atrial posterior wall in 5 cases and on the left atrial sutures in 2 cases. None of these thrombi had been detected by transthoracic echocardiography. No significant difference was observed between those with and those without thrombosis with respect to left atrial dimensions, left ventricular ejection fraction, cardiac index, pulmonary pressures and the number of episodes of acute rejection. The 4 patients with a history of arterial embolism all had an intra-atrial thrombus. This study demonstrates a high incidence of spontaneous contrast and intracardiac thrombi in the dilated left atrium of patients transplanted by Lower and Shumway's technique. It also underlines the value of transoesophageal echocardiography in the follow-up of transplant patients.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Service de cardiologie, hôpital Charles-Nicolle, Rouen.
authors.forename: G
authors.initials: G
authors.lastname: Derumeaux
authors.forename: D
authors.initials: D
authors.lastname: Mouton-Schleifer
authors.forename: M
authors.initials: M
authors.lastname: Redonnet
authors.forename: J P
authors.initials: JP
authors.lastname: Bessou
authors.forename: R
authors.initials: R
authors.lastname: Soyer
authors.forename: N
authors.initials: N
authors.lastname: Saoudi
authors.forename: A
authors.initials: A
authors.lastname: Cribier
authors.forename: B
authors.initials: B
authors.lastname: Letac
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D017548:Echocardiography, Transesophageal; D004617:Embolism / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006325:Heart Atria; D016027:Heart Transplantation / Q000009:adverse effects*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011184:Postoperative Period; D011237:Predictive Value of Tests; D012307:Risk Factors; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors
vernacular_title: Fréquence des thrombus intra-auriculaires détectés par l'échocardiographie transoesophagienne chez les transplantés cardiaques.