title: Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study.
authors.affiliation: Department of Chemistry, Wichita State University, KS 67260, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Groutas
authors.forename: R
authors.initials: R
authors.lastname: Venkataraman
authors.forename: L S
authors.initials: LS
authors.lastname: Chong
authors.forename: J E
authors.initials: JE
authors.lastname: Yoder
authors.forename: J B
authors.initials: JB
authors.lastname: Epp
authors.forename: M A
authors.initials: MA
authors.lastname: Stanga
authors.forename: E H
authors.initials: EH
authors.lastname: Kim
mesh_terms: D056649:Cathepsin G; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D019272:Leukocyte Elastase; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053146:Myeloblastin; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D007555:Isoxazoles; D011480:Protease Inhibitors; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; D053146:Myeloblastin