title: Cross calibration of QDR-2000 and QDR-1000 dual-energy X-ray densitometers for bone mineral and soft-tissue measurements.
abstract: Replacement of dual energy X-ray densitometry (DXA) equipment may be necessary in many labs with time, or new equipment may be added. In this context we compared patient scans between a Hologic QDR-1000W and a QDR-2000 (n = 29-43, depending on anatomic region) and between QDR-2000 single beam (SB) and fan beam (FB) modes (n = 40-62) as a quality control measure. A total of 83 subjects (79 females and four males) with a wide range of bone mineral densities (BMD) were studied. There was a linear relationship between results with the QDR-1000W and QDR-2000 in SB mode, and between SB and FB mode on the QDR-2000, but the magnitude of the coefficients and constants differed for the different anatomic regions. In SB mode the QDR-2000 underestimated whole body and forearm BMD by 3% relative to the QDR-1000W, even after cross calibration using a spine phantom. Femoral total BMD was slightly, but not significantly, underestimated. Thus, additional postanalysis correction had to be applied to forearm and whole-body scans. In FB with the QDR-2000, spine and whole-body BMD was underestimated by 3%, but femur total and neck BMD was overestimated by 2.2 and 2.8%, respectively, compared with SB scans on the same device. Soft-tissue composition with FB (enhanced analysis protocol) on the QDR-2000 differed greatly from that obtained using SB (standard protocol). Lean tissue mass was 4 kg lower and fat mass 4 kg higher in FB mode.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medical Endocrinology M, Odense University Hospital, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Abrahamsen
authors.forename: J
authors.initials: J
authors.lastname: Gram
authors.forename: T B
authors.initials: TB
authors.lastname: Hansen
authors.forename: H
authors.initials: H
authors.lastname: Beck-Nielsen
mesh_terms: D015502:Absorptiometry, Photon / Q000295:instrumentation* / Q000592:standards; D001823:Body Composition / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D002138:Calibration; D003238:Connective Tissue / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D011786:Quality Control; D012015:Reference Standards