title: Herpes simplex virus induces Fos expression in rat brainstem neurons.
abstract: After the injection of Herpes Simplex Virus type 1 into the rat cervical vagus nerve, transneuronally labelled virus-containing neurons and glial cells were present in the medulla oblongata. Fos-containing nuclei were present in the same regions of the brain. A double-labelling procedure revealed that most of the virus-positive neurons also contained Fos-positive nuclei. Appearance of HSV1 antigen within the CNS is associated with Fos expression in neurons and glial cells.
authors.affiliation: Department of Medicine, Flinders University, Bedford Park, Australia.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Gieroba
authors.forename: B S
authors.initials: BS
authors.lastname: Zhu
authors.forename: W W
authors.initials: WW
authors.lastname: Blessing
authors.forename: S L
authors.initials: SL
authors.lastname: Wesselingh
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D005786:Gene Expression Regulation / Q000502:physiology*; D016762:Genes, fos; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006561:Herpes Simplex / Q000378:metabolism* / Q000821:virology; D018259:Herpesvirus 1, Human; D007124:Immunoenzyme Techniques; D007700:Kinetics; D008297:Male; D009457:Neuroglia / Q000821:virology; D009474:Neurons / Q000821:virology; D051381:Rats
chemical_list: D005904:Glial Fibrillary Acidic Protein