Monoclonal antibody studies on rabies-related viruses.
Rabies and rabies-related viruses are divided into four serotypes, although it has been suggested that the inclusion of European bat lyssaviruses results in six genotypes. Sixty-four rabies-related viruses were tested against a panel of 36 anti-nucleocapsid monoclonal antibodies prepared from the immunization of Balb/c mice with five prototypic rabies-related viruses. Reaction patterns obtained confirmed the original distinction between serotype 1-4 viruses and revealed multiple variants of Lagos bat and Mokola viruses. In addition, two biotypes of European bat lyssavirus were identified and a clear distinction was shown between these biotypes and Duvenhage virus of Africa. The origins and importance of the rabies-related viruses are discussed.
King
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Central Veterinary Laboratory, New Haw, Weybridge, Surrey, United Kingdom.
D000818:Animals; D000911:Antibodies, Monoclonal; D001921:Brain / Q000821:virology; D002685:Chiroptera / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D011820:Rabies virus / Q000145:classification* / Q000302:isolation & purification; D012703:Serotyping
D000911:Antibodies, Monoclonal