Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.
Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.
Sepetov
N F
NF
Selectide Corporation, Tucson, AZ 85737, USA.
Krchnák
V
V
Stanková
M
M
Wade
S
S
Lam
K S
KS
Lebl
M
M
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal; D001426:Bacterial Proteins / Q000276:immunology; D015195:Drug Design; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D019809:Streptavidin; D001615:beta-Endorphin / Q000276:immunology
D000911:Antibodies, Monoclonal; D001426:Bacterial Proteins; D010455:Peptides; D001615:beta-Endorphin; D019809:Streptavidin