title: Endometrial morphometry in users of intrauterine contraceptive devices and women with ovulatory dysfunctional uterine bleeding: a comparison with normal endometrium.
abstract: Copper-bearing intrauterine contraceptive devices (IUCD) are commonly associated with menorrhagia. They cause certain morphological changes in the endometrium. These have been extensively reported and the mechanisms of menorrhagia have been investigated in a number of studies. By contrast, ovulatory dysfunctional uterine bleeding has not been as widely studied and mechanisms of menorrhagia in these patients are still not well understood. In this study, we examined endometrial morphometry in a group of women using IUCD, a group of women with ovulatory dysfunctional bleeding, and a control group of women with entirely normal cycles. There was increased leukocytic infiltration of the endometrium in both groups of women with menorrhagia compared to control cases. In addition, IUCD use was associated with greater luteal phase glandular epithelial height, supporting the concept of a secretory function defect in glandular epithelium. Possible links are postulated between static morphometric observations and dynamic biochemical changes.
authors.affiliation: Department of Obstetrics & Gynaecology, University of Sydney, NSW, Australia.
authors.forename: I Y
authors.initials: IY
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Russell
authors.forename: I S
authors.initials: IS
authors.lastname: Fraser
mesh_terms: D001315:Australia; D001706:Biopsy; D004717:Endometrium / Q000473:pathology*; D004727:Endothelium / Q000473:pathology; D005260:Female; D006801:Humans; D007435:Intrauterine Devices, Copper / Q000009:adverse effects*; D007962:Leukocytes / Q000473:pathology; D008183:Luteal Phase; D010049:Ovarian Diseases / Q000150:complications* / Q000473:pathology; D014592:Uterine Hemorrhage / Q000209:etiology* / Q000473:pathology