Characterization of an antithrombotic peptide from kappa-casein in newborn plasma after milk ingestion.
Bovine and human kappa-caseinoglycopeptides, two antithrombotic peptides derived from the corresponding kappa-caseins, were detected in physiologically active concentrations in the plasma of 5-d-old newborn infants after ingestion of cow's-milk-based formula or human milk respectively. It is suggested that these two bioactive peptides are released from milk proteins during digestion.
Chabance
B
B
CNRS URA 1188, Laboratoire des Protéines, Université de Paris V, France.
Jollès
P
P
Izquierdo
C
C
Mazoyer
E
E
Francoual
C
C
Drouet
L
L
Fiat
A M
AM
D000595:Amino Acid Sequence; D000818:Animals; D002364:Caseins / Q000097:blood* / Q000378:metabolism*; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005343:Fibrinolytic Agents / Q000097:blood*; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D008894:Milk Proteins / Q000032:analysis; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data
D002364:Caseins; D005343:Fibrinolytic Agents; D006020:Glycopeptides; D008894:Milk Proteins; C094310:kappa-caseinoglycopeptide