Continuing increase in mesothelioma mortality in Britain.
Mesothelioma is closely related to exposure to asbestos, and mesothelioma mortality can be taken as an index of past exposure to asbestos in the population. We analysed mesothelioma mortality since 1968 to assess the current state of the mesothelioma epidemic, and to predict its future course. We found that rates of mesothelioma in men formed a clear pattern defined by age and date of birth. Rates rose steeply with age showing a very similar pattern in all five-year birth cohorts. By date of birth, rates increased from mid-1893 to mid-1948, and then fell. Relative to the 1943-48 cohort, the risk for the 1948-53 cohort is 0.79 and for the 1953-58 cohort 0.48. Despite these falls, if the age profile of rates for these cohorts follows the pattern of past cohorts, their predicted lifetime mesothelioma risks will be 1.3%, 1.0%, and 0.6%. Combining projections for all cohorts results in a peak of annual male mesothelioma deaths in about the year 2020 of between 2700 and 3300 deaths. If diagnostic trend is responsible for a 20% growth in recorded cases every 5 years--an extreme but arguable case--and if this trend has now ceased, the peak of annual male deaths will be reduced to 1300, reached around the year 2010. Analysis of occupations recorded on death certificates indicate that building workers, especially plumbers and gas fitters, carpenters and electricians are the largest high-risk group. These data indicate that mesothelioma deaths will continue to increase for at least 15 and more likely 25 years. For the worst affected cohorts--men born in the 1940s--mesothelioma may account for around 1% of all deaths. Asbestos exposure at work in construction and building maintenance will account for a large proportion of these deaths, and it is important that such workers should be aware of the risks and take appropriate precautions.
Peto
J
J
Section of Epidemiology, Institute of Cancer Research, Belmont, Surrey, UK.
Hodgson
J T
JT
Matthews
F E
FE
Jones
J R
JR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001194:Asbestos / Q000009:adverse effects; D015331:Cohort Studies; D003644:Death Certificates; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D016273:Occupational Exposure / Q000009:adverse effects; D009790:Occupations; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D012306:Risk; D006113:United Kingdom / Q000453:epidemiology
D001194:Asbestos