title: A defined region of loss of heterozygosity at 11q23 in cutaneous malignant melanoma.
abstract: Karyotypic and molecular data indicate that genetic alterations of the long arm of chromosome 11 (11q) may be involved in malignant melanoma. To test this we analyzed 5 polymorphic microsatellite repeats on 11q using a PCR-based assay for loss of heterozygosity in normal and tumor tissues from 24 individuals with cutaneous malignant melanoma of various stages. Our findings indicate that a tumor suppressor gene that plays a role in malignant melanoma is located on the long arm of chromosome 11, likely within a 51 cM region at 11q23. Its loss appears to be a late event in tumor progression and may serve as an indicator for a less favorable clinical outcome.
authors.affiliation: Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla 92093-0660, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Herbst
authors.forename: A
authors.initials: A
authors.lastname: Larson
authors.forename: J
authors.initials: J
authors.lastname: Weiss
authors.forename: W K
authors.initials: WK
authors.lastname: Cavenee
authors.forename: G M
authors.initials: GM
authors.lastname: Hampton
authors.forename: K C
authors.initials: KC
authors.lastname: Arden
mesh_terms: D000328:Adult; D000368:Aged; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004247:DNA / Q000097:blood; D004273:DNA, Neoplasm / Q000032:analysis; D005819:Genetic Markers; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008545:Melanoma / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers; D004247:DNA