[Pathogenic approach of thrombopenia in dengue and its hemorrhagic complications].
Dengue is a frequent viral infection in the intertropical countries. The frequency and the severe forms of this infection are a real problem of public health. The haemorrhagic forms of the disease are constantly associated with thrombocytopenia. Its pathophysiology is still unclear. Among the different hypothesis, immune mechanisms play the main role. The authors discussed here the responsibility of the binding of immune complexes and the role of cytokines.
De Pina
J J
JJ
Service de Biologie Clinique, Hôpital d'Instruction des Armées Laveran, Marseille Armées.
Raphenon
G
G
Morillon
M
M
Fourcade
L
L
Martet
G
G
Touze
J E
JE
D000936:Antigen-Antibody Complex; D016207:Cytokines / Q000502:physiology; D003715:Dengue / Q000150:complications*; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D013921:Thrombocytopenia / Q000209:etiology* / Q000276:immunology
D000936:Antigen-Antibody Complex; D016207:Cytokines
Approche pathogénique de la thrombopénie dans la dengue et dans ses complications hémorragiques.