title: How are haemodynamic and metabolic responses to haemorrhage influenced by segmental thoracic and thoracolumbar epidural analgesia? An experimental study in dogs.
abstract: To determine the effects of the spread of sympathetic blockade administered prior to haemorrhage on haemodynamic and metabolic responses to haemorrhage, we compared these responses among dogs treated by segmental thoracic epidural analgesia, thoracolumbar epidural analgesia and general anaesthesia. Group 1 of six dogs received 0.2% halothane plus epidural analgesia ranging from C4 to T5, group 2 of seven 0.2% halothane plus epidural analgesia ranging from C5 to L7, and group 3 of eight 0.9% (1 MAC) halothane anaesthesia. A volume of 35 ml.kg-1 was bled over 30 min. The haemodynamic, metabolic and catecholamine variables were measured repeatedly at 30-min intervals for 2.5 h. The mean arterial pressure decreased significantly in all groups immediately after haemorrhage. It recovered to 80-90 mmHg at 2-2.5 h in groups 1 and 3 but remained at 20-30 mmHg in group 2. The cardiac output decreased significantly in all groups. The systemic vascular resistance increased significantly in group 1 but decreased significantly in group 2. In group 3 it decreased significantly but soon recovered. Arterial pH and base excess decreased significantly in all groups immediately after haemorrhage. After that, base excess recovered slowly in groups 1 and 3 but decreased further in group 2. The plasma epinephrine concentration increased immediately after haemorrhage and then decreased slowly in groups 1 and 3. In group 2 it remained unchanged at the lower level. The decreases in mean arterial pressure, systemic vascular resistance and base excess were significantly larger in group 2 than in groups 1 and 3.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology, Miyazaki Medical College, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Agune
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
mesh_terms: D000137:Acid-Base Imbalance / Q000503:physiopathology; D015360:Analgesia, Epidural; D000769:Anesthesia, Inhalation; D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D005260:Female; D006221:Halothane / Q000008:administration & dosage; D006339:Heart Rate; D006439:Hemodynamics; D006470:Hemorrhage / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology*; D006863:Hydrogen-Ion Concentration; D008159:Lumbar Vertebrae; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage; D009638:Norepinephrine / Q000097:blood; D011669:Pulmonary Wedge Pressure; D013904:Thoracic Vertebrae; D014655:Vascular Resistance
chemical_list: D008619:Mepivacaine; D006221:Halothane; D009638:Norepinephrine; D004837:Epinephrine