Addition of soybean trypsin inhibitor to bovine colostrum: effects on serum immunoglobulin concentrations in Jersey calves.
Secretion of trypsin by the neonate may reduce absorption of Ig from colostrum and increase failure of transfer of passive immunity, particularly for calves fed after 12 h of age. Jersey calves (n = 48) were used in a 2 x 2 factorial arrangement of soybean trypsin inhibitor (0 or 1 g) added to 1 L of maternal colostrum at the first two feedings and time of initial feeding (.65 or 12 h of age). A second colostrum feeding was offered 12 h after the initial feeding. Maternal colostrum was analyzed for Ig by radial immunodiffusion and trypsin inhibitor by radial protease diffusion. Jugular blood was sampled at 0, 12, 24, and 48 h after initial feeding, and serum was analyzed for IgG and IgM. Addition of trypsin inhibitor increased serum Ig and total serum protein concentrations, regardless of age at first feeding. Concentrations of serum IgG and IgM were increased 16 and 30%, respectively, when trypsin inhibitor was fed. Age of first feeding did not affect concentrations of IgG or IgM in serum. Supplementation of colostrum with trypsin inhibitor improved transfer of passive immunity to neonatal Jersey calves.
Quigley
J D
JD
Department of Animal Science, University of Tennessee, Knoxville 37901-1071, USA.
Martin
K R
KR
Dowlen
H H
HH
Lamar
K C
KC
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D003126:Colostrum; D004435:Eating; D005260:Female; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D010940:Plant Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D013025:Glycine max; D014361:Trypsin Inhibitors; D015430:Weight Gain; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D010940:Plant Proteins; D014361:Trypsin Inhibitors; D000516:alpha-Amylases