Cytogenetic study of a case of synchronous bilateral seminoma.
Cytogenetic analysis of a case of synchronous bilateral seminoma revealed, for each tumor, a chromosomal hypotetraploid mode with gain and loss of chromosomes and only one structural rearrangement, del(1p) and i(12p), which were secondary chromosomal events for the left and right tumors, respectively. This study allowed us to discriminate between a sole or independent origin for these two tumors.
Vénuat
A M
AM
Laboratoire de Cytogénétique et de Génétique Oncologiques, UA 1158 CNRS, Institut Gustave Roussy, Villejuif, France.
Droz
J P
JP
Terrier-Lacombe
M J
MJ
Machavoine
C
C
Bernheim
A
A
D000328:Adult; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009378:Neoplasms, Multiple Primary; D018239:Seminoma / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics*