title: Dopamine hypersensitivity in migraine: role in apomorphine syncope.
abstract: There is some evidence supporting a potential role of hypersensitivity of the dopaminergic system in the pathogenesis of migraine. In this case report, we describe a syncopal episode in a patient with migraine without aura after the administration of a very low dose of apomorphine, a classical agonist of dopaminergic receptors. The absence of cardiovascular risk factors in this patient suggests that the clinical event might have been caused by hypersensitivity of the dopaminergic system.
authors.affiliation: Department of Neurosciences B.B. Brodie, Headache Center, University of Cagliari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Del Zompo
authors.forename: M
authors.initials: M
authors.lastname: Lai
authors.forename: V
authors.initials: V
authors.lastname: Loi
authors.forename: M R
authors.initials: MR
authors.lastname: Pisano
mesh_terms: D000328:Adult; D001058:Apomorphine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008881:Migraine Disorders / Q000503:physiopathology*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013575:Syncope / Q000209:etiology*
chemical_list: D011954:Receptors, Dopamine; D001058:Apomorphine