title: Seronegative chronic relapsing neuroborreliosis.
abstract: We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids and free antigen.
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, New York, N.Y., USA.
authors.forename: C
authors.initials: C
authors.lastname: Lawrence
authors.forename: R B
authors.initials: RB
authors.lastname: Lipton
authors.forename: F D
authors.initials: FD
authors.lastname: Lowy
authors.forename: P K
authors.initials: PK
authors.lastname: Coyle
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid; D000937:Antigen-Antibody Reactions; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000188:drug therapy / Q000276:immunology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000188:drug therapy / Q000276:immunology*; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial