Genetic mapping of the mouse neuromuscular mutation kyphoscoliosis.
The ky mouse mutant, kyphoscoliosis, exhibits a degenerative muscle disease resulting in chronic deformation of the spinal column. Using an interspecific backcross segregating the ky mutation, we have mapped the ky locus to a small region of mouse chromosome 9. ky is nonrecombinant with the microsatellites D9Mit24 and D9Mit169 and lies in a conserved linkage group that encompasses human chromosome 3. s-Laminin (LAMS) and the gene for dystrophin-associated glycoprotein 1 (DAG1), which map to human chromosome 3, are both recombinant with ky, ruling them out as candidates.
Skynner
M J
MJ
Department of Biochemistry, Charing Cross and Westminster Hospital Medical School, London, United Kingdom.
Gangadharan
U
U
Coulton
G R
GR
Mason
R M
RM
Nikitopoulou
A
A
Brown
S D
SD
Blanco
G
G
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D017124:Conserved Sequence; D003433:Crosses, Genetic; D003598:Cytoskeletal Proteins / Q000235:genetics; D017931:DNA Primers; D049030:Dystroglycans; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007797:Laminin / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D051381:Rats; D012600:Scoliosis / Q000235:genetics*
D003598:Cytoskeletal Proteins; C483081:DAG1 protein, human; D017931:DNA Primers; D005819:Genetic Markers; D007797:Laminin; D008562:Membrane Glycoproteins; D049030:Dystroglycans