Common variable immunodeficiency in a renal transplant patient with severe recurrent bacterial infection: a case report and review of the literature.
The second reported case of common variable immunodeficiency (acquired agammaglobulinemia) after renal transplantation is presented. Agammaglobulinemia presumably resulted from long-standing immunosuppression. This case and our review of the literature indicate that agammaglobulinemia is a rare event after transplantation but can be treated successfully with intravenous immunoglobulin. Additionally, hypogammaglobulinemia occurs frequently after transplantation and should be monitored and treated in appropriate clinical situations. The treatment of our patient with intravenous immunoglobulin also suggests that patients with common variable immunodeficiency can undergo renal transplantation.
Miller
B W
BW
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.
Brennan
D C
DC
Korenblat
P E
PE
Goss
J A
JA
Flye
M W
MW
D000293:Adolescent; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D017074:Common Variable Immunodeficiency / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D011018:Pneumonia, Pneumococcal / Q000276:immunology*; D012008:Recurrence
D016756:Immunoglobulins, Intravenous; D001379:Azathioprine