Evaluation of anti-HTLV-1 antibody in primary glomerulonephritis.
Human T-cell leukaemia virus type-1 (HTLV-1) is known to cause adult T-cell leukaemia. The prevalence of anti-HTLV-1 antibody in haemodialysis patients has been reported to be higher than that in the general population. The anti-HTLV-1 antibody-positive rate in patients with primary glomerulonephritis in the Nagasaki district, an endemic area of HTLV-1, was evaluated. The antibody-positive rates in patients with primary glomerulonephritis (9.9%) and in haemodialysis patients (18.4%) were significantly higher than the rate in general blood donors (6.6%). Of 142 patients with primary glomerulonephritis, 14 (9.9%) were positive for the antibody; histological evaluation of these patients showed minor glomerular abnormality in one, mesangial proliferative glomerulonephritis in eight (IgA nephropathy in six and non-IgA nephropathy in two), membranous nephropathy in three, and crescentic glomerulonephritis in two. Evaluation of 10 antibody-positive patients by immunofluorescent microscopy showed immunocomplex-type nephritis in nine, suggesting the involvement of HTLV-1-associated antigen in the development and progression of glomerulonephritis.
Namie
S
S
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Shimamine
R
R
Ichinose
H
H
Nishikawa
Y
Y
Ideguchi
M
M
Ozono
Y
Y
Harada
T
T
Hara
K
K
D000293:Adolescent; D000328:Adult; D005069:Evaluation Studies as Topic; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology* / Q000276:immunology / Q000821:virology*; D015481:HTLV-I Antibodies / Q000097:blood*; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence
D015481:HTLV-I Antibodies