title: Mathematical model for a new mode of artificial ventilation: volume assisted pressure supported ventilation: a comparative study.
abstract: The patient submitted to artificial ventilation generally is connected to a high impedance flow source with controlled respiratory cycles to assure volume requirements or to a low impedance pressure source with spontaneous cycles to allow synchronization between his effort and system flow delivery. These two types of cycles represent the initial and final stages of artificial ventilation. The patient who needs a volume guarantee and at the same time presents unstable or insufficient inspiratory effort is difficult to manage with assisted cycles which are analogous to the controlled presence of a high impedance flow source. This paper presents a new approach where the respiratory cycles are obtained by the combination of flow and pressure sources using mathematical modeling. These cycles, named volume assisted pressure supported (VAPS) cycles, are compared with conventional assisted cycles showing a decrease in the patient work of breathing (WOB) during assisted ventilation. The theoretical results have been confirmed by clinical trials.
authors.affiliation: Bioengineering Division, Hospital das Clínicas University of São Paulo, Medical School, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Bonassa
mesh_terms: D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D012119:Respiration / Q000502:physiology; D012121:Respiration, Artificial / Q000379:methods*