Immunopathology of cardiac transplant rejection.
Transplant rejection represents a diverse series of complex immunological events beginning with allorecognition and lymphocyte activation and differentiation, followed by interactions of antibodies and activated lymphocytes with the vascular endothelium and subsequent cellular infiltration into the allograft, and, finally, the inflammatory process leading to tissue injury. This paper reviews how these events contribute to the different types of cardiac transplant rejection, including cardiac allograft vasculopathy.
Duquesnoy
R J
RJ
Department of Pathology, University of Pittsburgh Medical Center, PA 15213-2582, USA.
Demetris
A J
AJ
D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D016207:Cytokines / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology*; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D015815:Cell Adhesion Molecules; D016207:Cytokines