The remarkable coding strategy of borna disease virus: a new member of the nonsegmented negative strand RNA viruses.
BDV uses a remarkably broad range of mechanisms to direct expression of its 8.9-kb genome. Although much remains to be elucidated, it is clear that BDV genome expression is modulated by the use of multiple strategies, including differential gene transcription, post-transcriptional modification, and translational efficiency. Further insights into the details of this multilevel system will be essential to understanding BDV biology, pathogenesis, and neurotropism.
Schneemann
A
A
Department of Neurology, University of California at Irvine 92717, USA.
Schneider
P A
PA
Lamb
R A
RA
Lipkin
W I
WI
D000818:Animals; D001483:Base Sequence; D001891:Borna disease virus / Q000235:genetics*; D016384:Consensus Sequence; D015870:Gene Expression; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D014176:Protein Biosynthesis; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012328:RNA Viruses / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D013728:Terminator Regions, Genetic; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics
D012333:RNA, Messenger; D014764:Viral Proteins