[Protein profile in malnutrition states of the Ivory Coast child].
Prospectively assessment of nutritional status, besides anthropometric parameters measurements, included determination of the following plasma proteins: albumin, transferrin, retinol-binding protein and thyroxine-binding prealbumin, usually regarded as useful indices of protein depletion states. Patients' inflammatory or infectious diseases were investigated by measuring the two most reliable acute-phase reactants (orosomucoid and c-reactive protein). This study was conducted on a group of 56 pediatric patients malnourished and 54 age- and sex-matched healthy subjects as controls. Data showed a higher prevalence of inflammatory process during the course of malnutrition as revealed progressive but severe alteration of the Prognostic Inflammatory and Nutritional Index (PINI) or CRP x a1-GPA/Alb x TBPA. On the other hand, kwashiorkor and marasmus seemed to be a precipitating cause of infectious or/and inflammatory process. We, therefore, conclude that the PINI scoring system should be for the pediatricians, a sensitive and precious tool allowing the correct follow-up of inflammatory pole in nutritional disorders in developing countries.
Monnet
D
D
Laboratoire de Biochimie, Faculté de Pharmacie, Abidjan et Institut Pasteur.
Ahouty
C P
CP
Malan
K A
KA
Houenou
A Y
AY
Tebi
A
A
Yapo
A E
AE
D001798:Blood Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D002675:Child, Preschool; D007560:Cote d'Ivoire; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood / Q000150:complications; D008297:Male; D009748:Nutrition Disorders / Q000097:blood* / Q000150:complications; D009961:Orosomucoid / Q000378:metabolism; D011446:Prospective Studies; D012177:Retinol-Binding Proteins / Q000378:metabolism; D054839:Retinol-Binding Proteins, Plasma; D012709:Serum Albumin / Q000378:metabolism; D013975:Thyroxine-Binding Proteins / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
D001798:Blood Proteins; D009961:Orosomucoid; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D012709:Serum Albumin; D013975:Thyroxine-Binding Proteins; D014168:Transferrin; D002097:C-Reactive Protein
Profil protétique dans les états de malnutrition de l'enfant Ivoirien.