title: [Angiotensin II induces c-fos and c-myc proto-oncogene expression in the left ventricle].
abstract: In the present study, the effects of angiotension II on the expression of protooncogene c-fos and c-myc in the left ventricle were investigated on Langedorff heart preparations. It was observed that angiotensin induced both c-fos and c-myc expression in a dose-dependent manner and the c-fos expression showed an earlier appearance than c-myc. All these induced expressions were blocked by a Angiotensin II receptor antagonist saralasin. The Angiotensin II induced expression of c-fos was also blocked by TTX, but the c-myc gene expression was unaffected.
authors.affiliation: Laboratory of Receptor, Sun Yat-Sen University of Medical Sciences, Guangzhuo.
authors.forename: W H
authors.initials: WH
authors.lastname: Chen
authors.forename: D D
authors.initials: DD
authors.lastname: Tan
authors.forename: J Y
authors.initials: JY
authors.lastname: Pan
authors.forename: B R
authors.initials: BR
authors.lastname: Hu
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos; D016259:Genes, myc; D006352:Heart Ventricles; D066298:In Vitro Techniques; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012504:Saralasin / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D012333:RNA, Messenger; D000804:Angiotensin II; D013779:Tetrodotoxin; D012504:Saralasin