[The effect of emotional stress on the efficacy of chemotherapy in experimental trichochephaliasis].
In DBA/2st mice experimentally infected with Trichocephalus muris the emotional stress caused by a cat that was placed for 2 hours twice a day during 14 days or more was found to reduce the efficiency of specific drug therapy with albendasole. At the same time there was an increase in the ED84:ED16 ratio (the effective dose of the drug which allows 84 or 16% of helminths to be eliminated), which decreased elimination probability in the whole helminth populations.
Astaf'ev
B A
BA
Silla
M
M
Solomashin
N V
NV
D015766:Albendazole / Q000008:administration & dosage; D000818:Animals; D002415:Cats; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D013315:Stress, Psychological / Q000209:etiology / Q000503:physiopathology*; D013997:Time Factors; D014257:Trichuriasis / Q000188:drug therapy* / Q000469:parasitology / Q000503:physiopathology; D014258:Trichuris / Q000302:isolation & purification
D015766:Albendazole
Vliianie émotsional'nogo stressa na éffektivnost' khimioterapii pri éksperimental'nom trikhotsefaleze.