[Echocardiographic evaluation of the effect of treatment with captopril in patients with essential hypertension].
Numerous antihypertensive drugs act through different mechanisms so it is natural to expect their various effects on consecutive myocardial changes. This study included 40 patients with mild or moderate hypertension: 30 patients (19 male--63.3% and 11 female--36.7%), their mean age 40.1 year, who were treated with Kaptopril (Zorkaptil), and 10 patients (6 female--60% and 4 male--40%), their mean age 37.7 years, who received placebo. Before the beginning of the treatment and three months later the following data were analyzed: blood pressure, the left ventricular mass, the left ventricular mass index, shortening fraction, ejection fraction and the endsystolic left wall stress. Three months later in the group treated with Kaptopril significant reduction of blood pressure, left ventricular mass, left ventricular mass index and endsystolic left wall stress (p < 0.05) was found. The changes concerning ejection fraction and shortening fraction were not significant. Three months later, in the group which received placebo no changes could be found. It can be concluded that Kaptopril is an effective antihypertensive drug for treating some cases of mild and moderate hypertension as monotherapy not only because it control the blood pressure, but also because it significantly reduces the wall thickness of the left ventricular mass and of the endsystolic left wall stress.
Pavlović
K
K
Institut za kardiovaskularne bolesti, Sremska Kamenica, Medicinski fakultet, Novi Sad.
Atanacković
D
D
Dodić
S
S
D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male
D002216:Captopril
Ehokardiografska procena efekata lecenja kaptoprilom u bolesnika s esencijalnom hipertenzijom.