title: Diet effect on activity product ratios of uric acid, sodium urate, and ammonium urate in urine formed by healthy beagles.
abstract: Urine activity product ratios of uric acid, sodium urate, and ammonium urate and urinary excretion of metabolites were determined in 24-hour samples produced by 6 healthy Beagles during periods of consumption of a low-protein, casein-based diet (diet A) and a high-protein, meat-based diet (diet B). Comparison of effects of diet A with those of diet B revealed: significantly lower activity product ratios of uric acid (P = 0.025), sodium urate (P = 0.045), and ammonium urate (P = 0.0045); significantly lower 24-hour urinary excretion of uric acid (P = 0.002), ammonia (P = 0.0002), sodium (P = 0.01), calcium (P = 0.005), phosphorus (P = 0.0003), magnesium (P = 0.01), and oxalic acid (P = 0.004); significantly (P = 0.0001) higher 24-hour urine pH; and significantly (P = 0.01) lower endogenous creatinine clearance. These results suggest that consumption of diet A minimizes changes in urine that predispose dogs to uric acid, sodium urate, and ammonium urate urolithiasis.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Bartges
authors.forename: C A
authors.initials: CA
authors.lastname: Osborne
authors.forename: L J
authors.initials: LJ
authors.lastname: Felice
authors.forename: T A
authors.initials: TA
authors.lastname: Allen
authors.forename: C
authors.initials: C
authors.lastname: Brown
authors.forename: L K
authors.initials: LK
authors.lastname: Unger
authors.forename: L A
authors.initials: LA
authors.lastname: Koehler
authors.forename: K A
authors.initials: KA
authors.lastname: Bird
authors.forename: M
authors.initials: M
authors.lastname: Chen
mesh_terms: D000818:Animals; D002364:Caseins / Q000008:administration & dosage; D018753:Diet, Protein-Restricted / Q000662:veterinary*; D004044:Dietary Proteins / Q000008:administration & dosage; D004285:Dogs / Q000652:urine*; D005260:Female; D008460:Meat; D014527:Uric Acid / Q000652:urine*; D014545:Urinary Calculi / Q000209:etiology / Q000662:veterinary
chemical_list: D002364:Caseins; D004044:Dietary Proteins; D014527:Uric Acid