Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors.
Fourteen quinolizidine alkaloids, isolated from Lupinus albus, L. mutabilis, and Anagyris foetida, were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. Of the compounds tested, the alpha-pyridones, N-methylcytisine and cytisine, showed the highest affinities at the nicotinic receptor, while several quinolizidine alkaloid types were especially active at the muscarinic receptor.
Schmeller
T
T
Universität Heidelberg, Institut für Pharmazeutische Biologie, Germany.
Sauerwein
M
M
Sporer
F
F
Wink
M
M
Müller
W E
WE
D000470:Alkaloids / Q000302:isolation & purification / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D007887:Fabaceae / Q000737:chemistry*; D066298:In Vitro Techniques; D009538:Nicotine / Q000493:pharmacokinetics; D010946:Plants, Medicinal / Q000737:chemistry*; D011807:Quinolizines / Q000302:isolation & purification / Q000378:metabolism*; D011813:Quinuclidinyl Benzilate / Q000493:pharmacokinetics; D011976:Receptors, Muscarinic / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*; D013552:Swine
D000470:Alkaloids; D011807:Quinolizines; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D011813:Quinuclidinyl Benzilate; D009538:Nicotine