Diterpenoids from Isodon eriocalyx var. laxiflora.
Three new, seco-ent-kaurane diterpenoids, laxiflorins A, B and C, together with four known diterpenoids eriocalyxin B, oriodonin, and maeocrystals A and B, were isolated from the leaves of Isodon eriocalyx var. laxiflora. Their structures were assigned by a combination of one- and two-dimensional NMR techniques and computer modeling calculations. Laxiflorin C displayed weak cytotoxic activity.
Sun
H D
HD
Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Yunnan, P.R. China.
Lin
Z W
ZW
Niu
F D
FD
Shen
P Q
PQ
Pan
L T
LT
Lin
L Z
LZ
Cordell
G A
GA
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D001254:Astrocytoma; D001943:Breast Neoplasms; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D008175:Lung Neoplasms; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D010946:Plants, Medicinal; D011471:Prostatic Neoplasms; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; C516552:eriocalyxin B