Dioxides of bicyclic thiadiazines: a new family of smooth muscle relaxants.
The synthesis of dioxides of bicyclic thiadiazine related to diazoxide has been achieved. In a preliminary test, some of these compounds show smooth muscle relaxation similar to that obtained with the reference standard diazoxide.
Castro
A
A
Instituto de Química Médica (C.S.I.C.), Madrid, Spain.
Martínez
A
A
Cardelús
I
I
Llenas
J
J
D000818:Animals; D003981:Diazoxide / Q000494:pharmacology; D006168:Guinea Pigs; D009682:Magnetic Resonance Spectroscopy; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D013829:Thiadiazines; D003981:Diazoxide