title: CT muscle imaging and the clinical assessment of neuromuscular disease.
abstract: Twenty patients with neurogenic disorders, polymyositis, or muscular dystrophies were assessed clinically and by CT imaging of limb, limb girdle, and trunk muscles, using a standard protocol. On each side of these patients 26 movements were graded by the MRC scale, and 20 muscles were assessed by CT imaging. The clinical and CT findings could be compared, in a blind evaluation, in 10 muscles on each side. A quantitative assessment of the CT muscle images were also made. The CT images showed striking abnormalities, even in many muscles of normal strength by clinical testing. Asymmetrical involvement of muscles was found in all the disorders studied, even when not suspected on clinical examination. Muscles in patients with muscular dystrophy were more abnormal than those in patients with neurogenic disorders. In polymyositis the attenuation values were intermediate to the other two groups. A "washed-out" appearance with very low attenuation values was very suggestive of muscular dystrophy. Involvement of paraspinal and rectus abdominis muscles was uncommon in neurogenic disorders. The gracilis muscle was relatively resistant to degeneration. CT imaging can enhance the clinical assessment of patients with neuromuscular disease, often revealing unexpected abnormalities.
authors.affiliation: Department of Neurology, Royal London Hospital, UK.
authors.forename: M
authors.initials: M
authors.lastname: Swash
authors.forename: M M
authors.initials: MM
authors.lastname: Brown
authors.forename: C
authors.initials: C
authors.lastname: Thakkar
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000000981:diagnostic imaging; D006801:Humans; D007249:Inflammation; D009132:Muscles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009134:Muscular Atrophy, Spinal / Q000000981:diagnostic imaging; D009135:Muscular Diseases / Q000000981:diagnostic imaging; D009136:Muscular Dystrophies / Q000000981:diagnostic imaging; D009468:Neuromuscular Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017285:Polymyositis / Q000000981:diagnostic imaging / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000000981:diagnostic imaging; D012016:Reference Values; D014057:Tomography, X-Ray Computed