title: Effects on recipients of exposure to allogeneic donor leukocytes.
abstract: Blood transfusion recipients are exposed to allogeneic donor leukocytes at the time of transfusion. Exposure to allogeneic donor leukocytes has been linked to a variety of complications of transfusion including primary HLA alloimmunization and platelet refractoriness, febrile nonhemolytic transfusion reactions, transmission of leukotropic viruses, transfusion-associated graft versus host disease, and transfusion-induced immune suppression. The development of high-performance leukodepletion blood filters and of low-leukocyte plateletapheresis machines has provided the technology to reduce recipient exposure to allogeneic donor leukocytes. This article provides a brief review of current information on the utility and shortcomings of these technologies for the prevention of leukocyte-mediated transfusion complications.
authors.affiliation: Blood Bank and Tissue Typing Laboratory, Deaconess Hospital, Boston, Massachusetts 02215.
authors.forename: W H
authors.initials: WH
authors.lastname: Dzik
mesh_terms: D001782:Blood Donors; D001804:Blood Transfusion, Autologous / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000209:etiology; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D007108:Immune Tolerance; D007962:Leukocytes / Q000276:immunology* / Q000821:virology
chemical_list: D006680:HLA Antigens