title: Alcohol inhibits 11-beta-hydroxysteroid dehydrogenase activity in rat kidney and liver.
abstract: Male Wistar rats were treated with different ethanol concentrations diluted in drinking water in order to evaluate the effect of acute ethanol intoxication on 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) activity in liver and kidney tissue homogenates. Rats with the highest ethanol consumption (15% ethanol supplementation) showed a significant decrease in both hepatic and renal 11 beta-OHSD activity as compared to the control group (p < 0.005). In the same group, aldosterone plasma levels were significantly lower than in controls (p < 0.01), while corticosterone (B) plasma levels were slightly higher, suggesting that the increase in intrarenal B concentrations, probably related to the acute ethanol consumption, might be responsible for a nonspecific B mineralocorticoid activity.
authors.affiliation: Department of Cellular and Molecular Biology and Pathology, C.N.R., Naples; Italy.
authors.forename: R
authors.initials: R
authors.lastname: Valentino
authors.forename: A P
authors.initials: AP
authors.lastname: Tommaselli
authors.forename: S
authors.initials: S
authors.lastname: Savastano
authors.forename: P M
authors.initials: PM
authors.lastname: Stewart
authors.forename: M R
authors.initials: MR
authors.lastname: Ghiggi
authors.forename: F
authors.initials: F
authors.lastname: Galletti
authors.forename: P
authors.initials: P
authors.lastname: Mariniello
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
authors.forename: C R
authors.initials: CR
authors.lastname: Edwards
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D000431:Ethanol / Q000494:pharmacology*; D006913:Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
chemical_list: D000431:Ethanol; D000450:Aldosterone; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D003345:Corticosterone