[The effects of injection salviae miltiorrhizae in preventing and treating fat embolism syndrome].
This study was to examine the effects and mechanisms of injectio salviae miltiorrhizae (ISM) in preventing and treating fat embolism syndrome (FES), which was simulated by intravenous injection of homologous bone marrow fat in 16 dogs. PaO2, free fatty acids (FFAs), TXA2/PGI2, SOD/MDA were measured in different times combined with X-ray, conjunctiva microcirculation observation, radioisotope scanning and histologic examination. It was found that in the control group there were a significant fall in PaO alpha and rise in FFAs and MDA; blood clot stained with oil red O showed many fat droplets; radioisotope scanning revealed mild hypoperfusion or perfusion defects. In the treatment group, arterial oxygen levels were maintained, serum level of FFAS and MDA was reduced significantly. It is concluded that there is damage induced by oxygen-derived radicals in FES, LSM is an effective therapy for the FES, and 99mTc radioisotope scanning is a promising technique for noninvasive identification of FES in the early stage.
Gu
Z P
ZP
General Hospital of People's Liberation Army, Beijing.
Ma
C X
CX
Zhang
B X
BX
D000818:Animals; D003228:Conjunctiva / Q000098:blood supply; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004620:Embolism, Fat / Q000188:drug therapy / Q000517:prevention & control*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007275:Injections, Intravenous; D008168:Lung / Q000000981:diagnostic imaging; D008833:Microcirculation; D010936:Plant Extracts; D011877:Radionuclide Imaging; D027561:Salvia miltiorrhiza; D013667:Technetium
D004365:Drugs, Chinese Herbal; D005230:Fatty Acids, Nonesterified; D010936:Plant Extracts; D013667:Technetium