In vivo proton magnetic resonance spectroscopy in a case of Reye's syndrome.
A case of a 14-year-old boy with Reye's syndrome (RS) and complete neurologic recovery is presented. 1H magnetic resonance spectroscopy was performed on days 1 (admission to ICU), 8 and 62: During the acute phase of RS substantial cerebral metabolic imbalances were observed and their normalization monitored. The spectra from day 1 featured extremely high glutamine content (approximately 18 mmol/kg excess) and low concentrations of choline compounds pounds (approximately 1 mmol/kg deficit). Also some excess lactate was present. The subsequent spectra demonstrated the return to an almost normal brain metabolite profile.
Kreis
R
R
Department of Magnetic Resonance Spectroscopy, University and Inselspital, Bern, Switzerland.
Pfenninger
J
J
Herschkowitz
N
N
Boesch
C
C
D000293:Adolescent; D001921:Brain / Q000378:metabolism*; D002796:Choline Deficiency / Q000378:metabolism; D015600:Glasgow Coma Scale; D005973:Glutamine / Q000097:blood; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D012202:Reye Syndrome / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy
D005973:Glutamine