[Effects of isorhynchophylline on physiological characteristics of isolated guinea pig atrium].
Isorhynchophylline (Iso) inhibits the automaticity and contractile force of isolated guinea pig atrium in a concentration-dependent manner, 30 mumol/L markedly depresses adrenaline-induced automaticity, 10 mumol/L prolongs functional refractory period and decreases excitability. Furthermore, 10 mumol/L of Iso reduces the effect of ouabain on contractile force in left atrium and 0.3 mmol/L markedly inhibits the response to paired stimulation.
Zhu
Y
Y
Zunyi Medical College.
Huang
X
X
Liu
G
G
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000302:isolation & purification / Q000494:pharmacology*; D016279:Atrial Function, Left / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D006168:Guinea Pigs; D006325:Heart Atria; D066298:In Vitro Techniques; D026121:Indole Alkaloids; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010042:Ouabain / Q000037:antagonists & inhibitors; D000078183:Oxindoles; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; D000078183:Oxindoles; C052714:rhyncophylline; D010042:Ouabain