title: 3'-Demethoxy-3'-hydroxystaurosporine, a novel staurosporine analogue produced by a blocked mutant.
abstract: 3'-Demethoxy-3'-hydroxystaurosporine, 1 (CGP 58,546), a novel staurosporine analogue, was isolated from a mutant of Streptomyces longisporoflavus R19 blocked in the last step of the biosynthetic pathway. CGP 58,546 was less potent than staurosporine, but it showed a more selective inhibition pattern against various subtypes of protein kinase C.
authors.affiliation: Pharmaceutical Research Department, CIBA-GEIGY Ltd., Basle, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Hoehn
authors.forename: O
authors.initials: O
authors.lastname: Ghisalba
authors.forename: T
authors.initials: T
authors.lastname: Moerker
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D016296:Mutagenesis; D009154:Mutation; D016339:Spectrometry, Mass, Fast Atom Bombardment; D019311:Staurosporine / Q000031:analogs & derivatives; D013302:Streptomyces / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: C093980:3'-demethoxy-3'-hydroxystaurosporine; D000470:Alkaloids; D019311:Staurosporine