Autologous transfusion: current trends and research issues. National Heart, Lung, and Blood Institute Autologous Transfusion Symposium Working Group.
Dr. Toy concluded the meeting by summarizing the major controversial issues highlighted by the speakers. PABD PABD is, in principle, a safe and effective method for avoiding exposure to allogeneic blood in appropriate circumstances, and a substantial amount of clinical literature has been published to support its role. However, additional research is needed in the following areas: The optimal number of units that should be collected for specific surgical procedures to ensure maximum savings in use of allogenic blood and minimum wastage; The safety of PABD in patients, including a better understanding of which patients are at risk for complications, what the risks are, and what alternative collection strategies should be employed. Adequate control groups are needed in these studies; A definition of the transfusion trigger as it applies to autologous RBCs; An investigation of the role of rEPO in facilitating PABDs; The development of better collection logistics (e.g., double-unit collections) and storage protocols (e.g., improved additive solutions); and Additional studies of the costs associated with autologous blood collection and development of more cost-effective strategies. Acute normovolemic hemodilution Much of the published literature related to hemodilution describes the concept and specific protocols; in contrast, relatively little clinical research relating to the efficacy of this technique exists.(ABSTRACT TRUNCATED AT 250 WORDS)
D001804:Blood Transfusion, Autologous / Q000639:trends; D003362:Cost-Benefit Analysis; D006801:Humans; D012306:Risk; D014481:United States