title: The change of carnitine content in seminal plasma after reversible injection occlusion of vas deferens.
abstract: The change in carnitine content in seminal plasma after reversible injection occlusion of vas deferens (RIOVD) was observed. RIOVD is a safe, effective and simple method of male fertility control. Carnitine was determined by microenzymatic method. The incidence of sperm disappearance increased with the duration of RIOVD and reached 90% at the end of 12 months after operation. Before RIOVD, the mean value of carnitine in seminal plasma was 336.9 +/- 78.1 nmol/ml (X +/- SD, n = 58); after RIOVD, the mean value of seminal plasma carnitine was 112.7 +/- 50.7 nmol/ml (n = 172) in the group with sperm disappearance, and 172.5 +/- 71.7 nmol/ml (n = 51) in the group without sperm disappearance. There was a significant difference in carnitine content between pre-operation and postoperation (p < 0.01). After RIOVD, the carnitine concentration in seminal plasma of the group with sperm disappearance was lower than that of the group without sperm disappearance (p < 0.01). The results suggest that carnitine content in seminal plasma following RIOVD may be a reference index for judging the success or failure of the operation.
authors.affiliation: Department of Reproductive Physiology, Shandong Institute of Family Planning, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Qui
authors.forename: K
authors.initials: K
authors.lastname: Tian
authors.forename: D
authors.initials: D
authors.lastname: Yang
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
authors.forename: M
authors.initials: M
authors.lastname: Sun
authors.forename: S
authors.initials: S
authors.lastname: Mingzhang
mesh_terms: D002331:Carnitine / Q000378:metabolism*; D006801:Humans; D008297:Male; D012661:Semen / Q000378:metabolism*; D013076:Sperm Count; D013081:Sperm Motility; D014659:Vasectomy / Q000379:methods
chemical_list: D002331:Carnitine