35% CO2 challenge in panic and mood disorders.
20 patients with Panic Disorder (PD), 19 patients with Mood Disorder (MD) and 20 healthy controls inhaled one vital capacity of 35% CO2-65% O2 gas mixture and of compressed air in a double-blind, random, cross-over design. Only PD patients showed a strong reaction to 35% CO2 while MD patients and controls did not react significantly. These results support the specificity of the 35% CO2 challenge in PD patients and suggest that PD and MD are separate disorders.
Perna
G
G
Department of Neuropsychiatric Sciences, University of Milan, San Raffaele Hospital, Italy.
Barbini
B
B
Cocchi
S
S
Bertani
A
A
Gasperini
M
M
D000328:Adult; D000368:Aged; D001143:Arousal / Q000187:drug effects; D002245:Carbon Dioxide; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects; D016584:Panic Disorder / Q000175:diagnosis* / Q000523:psychology; D010555:Personality Inventory; D011237:Predictive Value of Tests; D012016:Reference Values
D002245:Carbon Dioxide