title: Radical AGEing in Alzheimer's disease.
abstract: The pathological presentation of Alzheimer's disease, the leading cause of senile dementia, involves regionalized neuronal death and an accumulation of intracellular and extracellular filamentous protein aggregates that form lesions termed neurofibrillary tangles and senile plaques, respectively. Several independent parameters have been suggested as the primary factor that is responsible for this pathogenesis, including apolipoprotein epsilon genotype, hyperphosphorylation of cytoskeletal proteins, or metabolism of amyloid beta. However, at present, no one theory explains adequately the host of complex biochemical and pathological facets of the disease. Recent findings suggest that age-related increases in oxidative stress and protein glycation either individually, or more probably in a synergistic manner, could, exclusive of the other theories or in concert with them, account for all aspects of Alzheimer's disease.
authors.affiliation: Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: L M
authors.initials: LM
authors.lastname: Sayre
authors.forename: V M
authors.initials: VM
authors.lastname: Monnier
authors.forename: G
authors.initials: G
authors.lastname: Perry
mesh_terms: D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000503:physiopathology*; D005609:Free Radicals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000502:physiology; D018384:Oxidative Stress
chemical_list: D005609:Free Radicals; D009419:Nerve Tissue Proteins