Changes of enzyme activities in the rat myocardium caused by experimental hypoxia with and without ginkgo biloba extract EGb 761 pretreatment. A cytophotometrical study.
Using cytophotometry activity changes of succinate dehydrogenase, glycerol-3-phosphate dehydrogenase and myofibrillar adenosine triphosphatase, were measured in the rat myocardium under normal and different experimental conditions. After hypoxia all enzyme activities were significantly decreased in comparison to the normal situation, and the alterations differed in both ventricles. Ginkgo biloba extract treatment over three months before exposition to hypoxia resulted in a lower inhibition of succinate dehydrogenase, a higher inhibition of glycerol-3-phosphate dehydrogenase and an unchanged activity of adenosine triphosphatase after hypoxia of 20 min. These results were interpreted as a protective effect of the Ginkgo biloba extract on the hypoxic myocardium.
Punkt
K
K
Institute of Anatomy, University of Leipzig, Germany.
Welt
K
K
Schaffranietz
L
L
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D016166:Free Radical Scavengers; D020441:Ginkgo biloba; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006651:Histocytochemistry; D000860:Hypoxia / Q000201:enzymology* / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D008297:Male; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D009210:Myofibrils / Q000201:enzymology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D000096983:Ginkgo Extract
D000251:Adenosine Triphosphatases; D016166:Free Radical Scavengers; D005993:Glycerolphosphate Dehydrogenase; D010936:Plant Extracts; D013385:Succinate Dehydrogenase; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract