title: [Changes in gut hormones after Roux-en-Y cholangio-jejunostomy].
abstract: In order to explore the mechanism of secondary gastric acid hypersecretion after Roux-en-Y Cholangio-jejunostomy (CJR-Y), we studied the changes of gastric acid secretion and determined the levels of somatostatin (SS), gastrin (Gn), neurotensin (NT), beta-endorphin (beta-EP) in serum, gastric juice and pyloric antrum in patients with CJR-Y. The results showed that gastric hypersecretion developed, levels of SS in those specimens decreased significantly and the content of Gn increased obviously after CJR-Y; whereas the content of NT and beta-EP did not change significantly. We concluded that the decreased level of SS plays a role in the mechanism.
authors.affiliation: South-West Hospital, Third Military Medical College, Chongqing.
authors.forename: K S
authors.initials: KS
authors.lastname: Ma
authors.forename: G X
authors.initials: GX
authors.lastname: Qian
authors.forename: Z P
authors.initials: ZP
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D000713:Anastomosis, Roux-en-Y; D001652:Bile Ducts / Q000601:surgery*; D001660:Biliary Tract Diseases / Q000378:metabolism / Q000601:surgery; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D008875:Middle Aged; D009496:Neurotensin / Q000378:metabolism; D011183:Postoperative Complications; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D005755:Gastrins; D009496:Neurotensin; D013004:Somatostatin