Variations in oral glucose tolerance tests: the 100- versus 75-g controversy.
This study compared the results of a 75-g, 3-hour oral glucose tolerance test with those of a traditional 100-g oral glucose tolerance test. Thirty-two pregnant women participated in the study. Each patient served as her own control, undergoing both a 100- and a 75-g oral glucose tolerance test within 1 week. Despite a strong positive correlation between the results of the two tests, the 1-, 2-, and 3-hour glucose values of the 100-g glucose load were significantly higher than the comparable values of the 75-g oral glucose tolerance test. Sixteen of 32 women were diagnosed as having gestational diabetes mellitus using the National Diabetes Data Group criteria and the 100-g oral glucose tolerance test, whereas only 6 of these 16 women would have been identified with the 75-g oral glucose tolerance test. If data from one test are to be compared with the other, new thresholds of glucose abnormality need to be developed.
Brustman
L E
LE
Department of Obstetrics and Gynecology, Our Lady of Mercy Medical Center, Bronx, New York, USA.
Gela
B D
BD
Moore
M
M
Reilly
K D
KD
Langer
O
O
D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D016640:Diabetes, Gestational / Q000175:diagnosis*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D015203:Reproducibility of Results
D005947:Glucose