title: Abrupt-onset diabetes mellitus in the elderly.
abstract: We present three elderly Japanese patients with abrupt onset of diabetes mellitus: a 61-year-old male with a complete defect of insulin secretion without insulin resistance, a 60-year-old male with an incomplete defect of insulin secretion associated with insulin resistance, and a 69-year-old female with a complete defect of insulin secretion and insulin resistance. The findings in these cases indicate the heterogeneity in insulin secretion and sensitivity of abrupt onset diabetes mellitus in the elderly. The changes in insulin secretion and sensitivity over time due to glucose toxicity may at least partially explain the heterogeneity.
authors.affiliation: Second Department of Internal Medicine, Kochi Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Takamatsu
authors.forename: T
authors.initials: T
authors.lastname: Yorioka
authors.forename: H
authors.initials: H
authors.lastname: Kurokawa
authors.forename: T
authors.initials: T
authors.lastname: Itahara
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Numata
authors.forename: S
authors.initials: S
authors.lastname: Uga
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005947:Glucose / Q000009:adverse effects*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose