title: [Static and dynamic MR tomography of the pancreas: contrast media kinetics of the normal pancreatic parenchyma in pancreatic carcinoma and chronic pancreatitis].
abstract: OBJECTIVE
  We aimed both at improving image quality and diagnostic value of pancreatic MRI by using fast multislice imaging techniques and at demonstrating normal and pathologic signal enhancement in the pancreas after i.v. gadopentate-dimeglumine.
  
  
  METHODS
  MR imaging at was performed in 30 patients with suspicion of pancreatic neoplasm or chronic disease and in 15 patients without pancreatic abnormalities.
  
  
  RESULTS
  SNR, CNR, mean signal enhancement, and time/signal-intensity curves were calculated. Signal enhancement after i.v. Gd-DTPA averaged 34.4% in neoplasms (n = 14) vs 58.8% in pancreatic tissue not involved by tumour (p < 0.05) in T1-w SE and was also significant in the T1-w GE sequence (p < 0.005). CNR (pancreas vs lesion) and SNR improved significantly (p < 0.005; pancreas: p < 0.001; lesion: p < 0.05) after i.v. Gd-DTPA administration. In patients without pancreatic disease enhancement curves of pancreas demonstrate a rapid signal increase (79.0% after 34 s). Patients with adenocarcinoma or chronic pancreatitis demonstrated flattened signal intensity curves and higher peak signal intensity values (90.1, 111.3% after 68 s). The slope of signal increase of neoplastic tissue was significantly different (p < 0.01) from unaffected parenchyma (48.3% after 51 s, 90.1% after 68 s).
  
  
  CONCLUSIONS
  MR imaging with fast T2-w SE and T1-w SE sequences provides excellent visualisation of the pancreas and adequate conspicuity of pancreatic adenocarcinoma. Following i.v. Gd-DTPA significant enhancement of tumour/parenchyma contrast is found.
authors.affiliation: Institut für Radiologische Diagnostik, Klinikum Grosshadern LMU München.
authors.forename: H
authors.initials: H
authors.lastname: Sittek
authors.forename: A F
authors.initials: AF
authors.lastname: Heuck
authors.forename: C
authors.initials: C
authors.lastname: Fölsing
authors.forename: J
authors.initials: J
authors.lastname: Gieseke
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D010195:Pancreatitis / Q000175:diagnosis*; D004369:Pentetic Acid / Q000031:analogs & derivatives
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA
vernacular_title: Statische und dynamische Kernspintomographie des Pankreas: Kontrastmittelkinetik des normalen Pankreasparenchyms bei Pankreaskarzinomen und chronischer Pankreatitis.