title: Hepatic disease associated with administration of tetanus antitoxin in eight horses.
abstract: Seven horses developed clinical or subclinical hepatitis 48 to 87 days after administration of tetanus antitoxin. One horse had mildly high hepatic enzyme activity 120 days after inoculation with tetanus antitoxin. The first horse developed signs of depression, lethargy, and anorexia. During hospitalization, signs of hepatoencephalopathy were noticed, and laboratory data were consistent with hepatic disease. Another horse that was found dead had gross and histologic lesions compatible with serum hepatitis. Screening of serum gamma-glutamyltransferase (GGT) and aspartate transaminase activities were used to investigate the remaining horses in the herd. High GGT activities (71 to 206 IU/L) were detected in 5 additional herd members. These horses appeared clinically normal, apart from 2 reports of nasal photosensitization and an aborted fetus. In 3 horses, high serum GGT activity persisted over a 44-day testing period. All affected horses had been given tetanus antitoxin within 12 hours of parturition, and a common source of vaccine was identified for 7 horses. Findings in this group of horses indicate that clinical and subclinical serum hepatitis can develop after administration of tetanus antitoxin.
authors.affiliation: Department of Medicine and Surgery, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Guglick
authors.forename: C G
authors.initials: CG
authors.lastname: MacAllister
authors.forename: R W
authors.initials: RW
authors.lastname: Ely
authors.forename: W C
authors.initials: WC
authors.lastname: Edwards
mesh_terms: D000818:Animals; D005260:Female; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000662:veterinary; D006520:Hepatitis, Animal / Q000097:blood / Q000209:etiology*; D006734:Horse Diseases / Q000097:blood / Q000209:etiology*; D006736:Horses; D008297:Male; D011379:Prognosis; D013743:Tetanus Antitoxin / Q000009:adverse effects*; D000637:Transaminases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D013743:Tetanus Antitoxin; D005723:gamma-Glutamyltransferase; D000637:Transaminases