Eosinophil eicosanoid relations in allergic inflammation of the airways.
Eosinophils are prominent features of allergic inflammation and can contribute to this process through release of inflammatory enzymes, granule-associated proteins, and leukotriene products. There is considerable interest in the fact that selected cytokines enhance eosinophil generation of leukotrienes. Therefore, future directions must include efforts to identify factors that regulate eosinophil synthesis of leukotrienes and therapeutic agents that might control these specific inflammatory responses.
Busse
W W
WW
University of Wisconsin Medical School, Allergy Section, Madison 53792, USA.
Sedgwick
J B
JB
D001249:Asthma / Q000276:immunology; D003545:Cysteine / Q000378:metabolism; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity; D017997:Leukotriene C4 / Q000096:biosynthesis; D015289:Leukotrienes / Q000502:physiology*; D012140:Respiratory Tract Diseases / Q000276:immunology*
D015289:Leukotrienes; D017997:Leukotriene C4; D003545:Cysteine