[The transplacental passage and distribution of ceftazidime in the fetal and maternal organs in a 2nd-trimester abortion].
Transplacental passage of ceftazidime was studied in 17 women with second-trimester pregnancy which had to be discontinued for medical causes. A single intramuscular injection of the antibiotic resulted in creation of therapeutically active concentrations in fetal blood and organs, amniotic fluid, and placenta. Transplacental passage of ceftazidime from the mother to the fetus was 19.12%, diffusions to the amniotic fluid 14.46%, diffusion to the placenta 48.46%. Ceftazidime may be effective for the prevention and therapy of fetal intrauterine infection and chorioamnionitis.
Kulakov
V I
VI
Voropaeva
S D
SD
Kasabulatov
N M
NM
D000032:Abortion, Therapeutic; D000293:Adolescent; D000328:Adult; D002442:Ceftazidime / Q000032:analysis / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013997:Time Factors; D014018:Tissue Distribution
D002442:Ceftazidime
Transplatsentarnyĭ perekhod i raspredelenie tseftazidima v organakh ploda i zhenshchin pri preryvanii beremennosti vo II trimestre.