Appearance of isochromosome 18q can be associated with in vitro immortalization of human T lymphocytes.
T lymphocytes cultured from a skin biopsy specimen of a patient with atopic dermatitis developed isochromosome 18q concomitant to escape from replicative senescence. Furthermore, two T-cell lines established from patients with cutaneous T-cell lymphoma also developed isochromosome 18q during continuous growth. The results indicate that a pathway leading to immortalization of human T lymphocytes could involve genes located at chromosome 18.
Kaltoft
K
K
Institute of Human Genetics, Aarhus University, Denmark.
Pedersen
C B
CB
Hansen
B H
BH
Thestrup-Pedersen
K
K
D002455:Cell Division / Q000235:genetics*; D002460:Cell Line / Q000648:ultrastructure; D002478:Cells, Cultured / Q000648:ultrastructure; D002887:Chromosomes, Human, Pair 18; D003876:Dermatitis, Atopic / Q000235:genetics; D006801:Humans; D018404:Isochromosomes / Q000235:genetics*; D007621:Karyotyping; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics; D009182:Mycosis Fungoides / Q000235:genetics; D012751:Sezary Syndrome / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics; D013601:T-Lymphocytes / Q000166:cytology* / Q000648:ultrastructure