Adaptive control in drug therapy.
In medical practice, drugs are administered with the goal of attaining a therapeutic effect without exceeding predetermined safety limits on any adverse action. This paper is intended to provide an introduction to pharmacokinetic-model based adaptive control of drug levels that can be of use in achieving such therapeutic objectives. The principles are illustrated by the problem of providing rapid relief of acute asthmatic symptoms by infusing theophylline.
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Computer Centre, Semmelweis University of Medicine, Budapest, Hungary.
D000222:Adaptation, Physiological / Q000502:physiology*; D016903:Drug Monitoring / Q000592:standards; D004358:Drug Therapy / Q000592:standards*; D006801:Humans; D010599:Pharmacokinetics; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics
D013806:Theophylline