title: Heterocyclic betaines. XXII. Azinium(azolium) 4-nitrobenzimidazolate inner salts and their derivatives with several interannular spacers. Synthesis, characterization and antitrichomonal activity.
abstract: The synthesis of an ensemble of pyridinium(imidazolium) 4-nitrobenzimidazolate betaines and their derivatives with several interannular linkages has been explored. Their antiprotozoal activity has also been examined.
authors.affiliation: Laboratorio de Química Orgánica, Facultad de Farmacia, Universidad de Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Alcalde
authors.forename: L
authors.initials: L
authors.lastname: Pérez-García
authors.forename: I
authors.initials: I
authors.lastname: Dinarés
authors.forename: J
authors.initials: J
authors.lastname: Frigola
mesh_terms: D000818:Animals; D000994:Antitrichomonal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000994:Antitrichomonal Agents; D001562:Benzimidazoles; D001622:Betaine