Fluorophotometric study of lens autofluorescence and the blood-retinal barrier in 56 diabetic patients.
We examined lens autofluorescence and the permeability of the blood-retinal barrier in 56 diabetic patients (34 insulin-dependent and 22 non-insulin-dependent), using the Fluorotron Master (R), a commercially available fluorophotometer. Significant relationships were found between age and lens autofluorescence (p < 0.01), between duration of diabetes and lens autofluorescence in insulin-dependent diabetics (p < 0.01), and between duration of diabetes and blood-retinal barrier permeability in all diabetics (p < 0.05). The relationships between lens autofluorescence and duration of diabetes in non-insulin dependent patients (p > 0.05), and between lens autofluorescence or the penetration ratio and HBA Ic during the five preceding years (p > 0.05) were not significant. Fluorophotometry provides an objective and reproducible method for in vivo investigation of the ocular complications of diabetes and of the factors influencing them.
Bordat
B
B
Department of Ophthalmology, Gui de Chauliac Hospital, Montpellier, France.
Arnaud
C
C
Guirguis
I R
IR
Laudeho
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001813:Blood-Retinal Barrier; D002199:Capillary Permeability / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D005453:Fluorescence; D015590:Fluorophotometry; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
D005452:Fluoresceins; D019793:Fluorescein