[The neuroendocrine regulation of gonadotropin and prolactin secretion and the role of neuromediators].
The paper deals with the neuroendocrine relationships between true neuromediators of adrenergic and cholinergic nature as well as the neuromediators of peptidic character and the neurosecretory neurons controlling the secretion of gonadotropines and prolactine. The properties of about 30 neuromediators of different character with consideration for the structures of the central nervous system, participation in the synthesis and secretion of gonadoliberine, gonadotropines and prolactine and hence functioning of the reproductive system as a whole are characterized. The significance of the hormonal background of sexual steroids in the system of these complex relationships is analyzed. The author's and literature findings on the time-course of changing the contents of catecholamines in the hypothalamic structures relating to the control of the gonadotropic function of pituitary body are studied; the correlation relationships between a changed level of sexual steroids and gonadotropines in the blood during the cycle and the time-course of changing the catecholamines and luliberine in the hypothalamus are discussed. The possible mechanisms of coordinating the different neuromediators of adrenergic character and amino neuromediators with various mechanisms of action in the regulation of normal activity of the reproductive system are investigated.
Babichev
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D000818:Animals; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009490:Neurosecretory Systems / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism*
D006065:Gonadotropins, Pituitary; D018377:Neurotransmitter Agents; D011388:Prolactin
Neĭroéndokrinnaia reguliatsiia sekretsii gonadotropinov i prolaktina i rol' neromediatorov v neĭ.