title: Psychological stress and immunological responsiveness in normally cycling, follicular-stage women.
abstract: Nineteen women in the follicular stage of their menstrual cycles were assessed for immunological responsiveness to a 50-min series of three psychological tasks which reliably elicit cardiovascular and neuroendocrine stress responses. Ten follicular-stage women not subjected to stress served as controls. Stress decreased lymphocyte responsiveness to PHA and PWM, percent of CD4+ cells and the ratio of CD4+/CD8+ cells. Conversely, stress increased natural killer cell number and cytolytic activity, white blood cell, lymphocyte, T and B cell count. Except for natural killer cell number, none of these changes was exhibited by controls. Most of these stress responses are similar to those reported for men and form the basis for a continuing study of the effects of reproductive hormones and stress on cardiovascular and immunological function in women.
authors.affiliation: Department of Psychology, University of Pittsburgh, PA 15260, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Caggiula
authors.forename: C G
authors.initials: CG
authors.lastname: McAllister
authors.forename: K A
authors.initials: KA
authors.lastname: Matthews
authors.forename: S L
authors.initials: SL
authors.lastname: Berga
authors.forename: J F
authors.initials: JF
authors.lastname: Owens
authors.forename: A L
authors.initials: AL
authors.lastname: Miller
mesh_terms: D000328:Adult; D016516:CD4-CD8 Ratio; D005260:Female; D005498:Follicular Phase; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D013315:Stress, Psychological / Q000276:immunology*