[Nootropic substances enhance the N-methyl-D-aspartate-induced short-term potentiation of synaptic transmission in rat hippocampal slices].
The nootropic agents pyracetam, ethymisole, N-5-oxynicotinoyl glutamate and beta-carboline derivative--ambocarb--enhance short-term potentiation of populational EPSP's amplitude of area CA1 pyramidal neurons in the slices of the rat hippocampus, which is evoked by NMDA. The inhibitors of protein kinases diminish the effect of pyracetam and ethymisole (tolbutamide), as well as all the studied nootropic drugs (polymyxin B and trifluoroperazine).
Abramets
I I
II
Andreev
P V
PV
Samoĭlovich
I M
IM
D000818:Animals; D004357:Drug Synergism; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D016202:N-Methylaspartate / Q000494:pharmacology*; D018697:Nootropic Agents / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D018697:Nootropic Agents; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate
Nootropnye veshchestva usilivaiut vyzyvaemuiu N-metil-D-aspartatom kratkosrochnuiu potentsiatsiiu sinapticheskoĭ peredachi v srezakh gippokampa krys.