title: Effect of methacholine on mucociliary transport in bovine trachea in vitro.
abstract: A method is described to evaluate pharmacologic influence on bovine tracheal mucus transport in vitro. In this model, cholinergic agonist methacholine stimulated transport velocity. Methacholine at concentration of 10(-6)M increased velocity by 13.6%, whereas 10(-5)M increased velocity by 26%. Stimulation was inhibited by atropine.
authors.affiliation: Department of Large Animal Medicine and Nutrition, Veterinary Faculty, Utrecht, The Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: Mars
authors.forename: P A
authors.initials: PA
authors.lastname: Henricks
authors.forename: R
authors.initials: R
authors.lastname: Hajer
authors.forename: H J
authors.initials: HJ
authors.lastname: Breukink
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002417:Cattle; D002923:Cilia / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D016210:Methacholine Chloride / Q000494:pharmacology*; D009068:Movement / Q000187:drug effects; D009093:Mucus / Q000187:drug effects / Q000502:physiology*; D014132:Trachea / Q000502:physiology*
chemical_list: D016210:Methacholine Chloride; D001285:Atropine