Inhaled mycotoxins lead to acute renal failure.
Mysterious deaths of archeologists after opening Egyptian tombs have been suspected, but never proved, to be secondary to inhalation of mycotoxin. We observed a case of acute renal failure (ARF) due to inhalation of ochratoxin A produced by a mould of the species Aspergillus ochraceus. After working 8 h in a granary closed for several months, a farmer and his wife suffered respiratory distress; the woman developed non-oliguric ARF and biopsy revealed tubulonecrosis. A strain of Aspergillus ochraceus producing ochratoxin was isolated from the wheat.
Di Paolo
N
N
Nephrology and Dialysis Unit, USL 30, Siena Regional Hospital, Italy.
Guarnieri
A
A
Garosi
G
G
Sacchi
G
G
Mangiarotti
A M
AM
Di Paolo
M
M
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000280:Administration, Inhalation; D000383:Agriculture; D000818:Animals; D001235:Aspergillus ochraceus / Q000302:isolation & purification; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology / Q000473:pathology; D009793:Ochratoxins / Q000008:administration & dosage / Q000009:adverse effects* / Q000302:isolation & purification; D011817:Rabbits; D014908:Triticum / Q000382:microbiology
D009793:Ochratoxins; C025589:ochratoxin A