title: Conjugated hyperbilirubinemia in a newborn infant after maternal (transplacental) treatment with flecainide acetate for fetal tachycardia and fetal hydrops.
abstract: An infant with intrauterine supraventricular tachycardia and fetal hydrops, successfully treated with administration of flecainide acetate to the mother had conjugated hyperbilirubinemia shortly after birth. An extensive evaluation failed to disclose a known cause. We believe that in utero exposure to flecainide acetate resulted in conjugated hyperbilirubinemia in this infant.
authors.affiliation: Division of Neonatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Vanderhal
authors.forename: J
authors.initials: J
authors.lastname: Cocjin
authors.forename: T V
authors.initials: TV
authors.lastname: Santulli
authors.forename: D E
authors.initials: DE
authors.lastname: Carlson
authors.forename: P
authors.initials: P
authors.lastname: Rosenthal
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D005424:Flecainide / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015160:Hydrops Fetalis / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013610:Tachycardia / Q000188:drug therapy*
chemical_list: D005424:Flecainide