Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.
Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.
Mahley
R W
RW
Gladstone Institute of Cardiovascular Disease, Department of Pathology, University of California, San Francisco, USA.
Nathan
B P
BP
Bellosta
S
S
Pitas
R E
RE
D000544:Alzheimer Disease / Q000209:etiology*; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*
D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E