title: Change of flow cytometric DNA content in para-aortic lymph node showing recurrence after adjuvant chemotherapy for gastric cancer.
abstract: A para-aortic lymph node showing recurrence was resected from a patient who had received adjuvant chemotherapy after curative resection of an advanced gastric cancer. A flow cytometric analysis of DNA content was carried out for the primary lesion, a metastatic lymph node and the resected lymph node. A peri-diploid cell population in addition to diploid cells appeared in the recurrent lesion, whereas a major diploid cell population and a minor aneuploid cell population were found in the primary lesion and the metastatic lymph node, indicating that a clone of chemo-resistant tumor cells selectively multiplied after the cytotoxic therapy. The characters of a recurrent lesion may be changed by clonal selection following chemotherapy.
authors.affiliation: Department of Surgery II, Osaka University Medical School, Suita, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsujinaka
authors.forename: Y
authors.initials: Y
authors.lastname: Doki
authors.forename: H
authors.initials: H
authors.lastname: Shiozaki
authors.forename: A
authors.initials: A
authors.lastname: Miyamoto
authors.forename: T
authors.initials: T
authors.lastname: Mori
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D001011:Aorta; D017024:Chemotherapy, Adjuvant; D004273:DNA, Neoplasm / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics*; D008297:Male; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm