title: Peptide T from human immunodeficiency virus does not interact with VIP receptor-effector system in immunocompetent cells of rat and mouse.
abstract: Human immunodeficiency virus (HIV) infection is initiated by attachment of the virus to specific target cells. An octapeptide sequence contained within the envelope of HIV, peptide T, mediates the viral binding. Since there is an appreciable structural similarity between peptide T and an eight amino acid sequence of VIP, it is interesting to investigate the interaction of peptide T with the VIP receptor-effector system of immunocompetent cells from both rat and mouse. In this paper, we show the lack of interaction between peptide T and VIP receptor-effector system in peripheral blood lymphocytes, spleen lymphocytes and macrophages of rat and in macrophages of mouse. These results do not support the hypothesis that HIV through peptide T may interact with the VIP receptor-effector system present in immunocompetent cells.
authors.affiliation: Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Pozo
authors.forename: J J
authors.initials: JJ
authors.lastname: Segura
authors.forename: J M
authors.initials: JM
authors.lastname: Guerrero
authors.forename: J R
authors.initials: JR
authors.lastname: Calvo
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000096:biosynthesis; D006678:HIV / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D015717:Peptide T / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
chemical_list: D015717:Peptide T; D014660:Vasoactive Intestinal Peptide; D000242:Cyclic AMP