[The effect of prostaglandin E1 on myocardial ischemia reperfusion injury].
The effect of prostaglandin E1 (PGE1) on ischemia reperfusion injury (IRI) was investigated. The changes of leucocytes in venous blood and infarcted myocardial tissue and the level of lipid peroxide (LPO), superroxide dismutase (SOD) and catalase (CAT) were also studied in these animal models at the same time. The experimental results were as follows: the count and activity of leucocytes and the level of LPO in IRI were obviously increased. The activity of SOD and CAT in the untreated group was much lower than that in the treated group (P < 0.01). The infarcted size (IS) was larger in the untreated group. The count of leucocytes was positively related with the level of LPO and IS, but negatively related with the activity of SOD and CAT. However, the relationship disappeared after the administration of PGE1. These data suggested that leucocyte plays an important role in IRI. PGE1 can inhibit leucocyte activity, decrease peroxidation, reduce LPO production and increase the activity of SOD and CAT. It can decrease the infarct size. PGE1 takes the main role in protecting IRI.
Wang
L
L
3rd Teaching Hospital, Bethune University of Medical Sciences, Changchun.
Wu
J
J
Sun
X
X
D000527:Alprostadil / Q000627:therapeutic use*; D000818:Animals; D002374:Catalase / Q000097:blood; D004285:Dogs; D005260:Female; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology; D009504:Neutrophils / Q000502:physiology; D013482:Superoxide Dismutase / Q000097:blood
D008054:Lipid Peroxides; D002374:Catalase; D013482:Superoxide Dismutase; D000527:Alprostadil