Chemical and bioactive constituents from Zanthoxylum simulans.
Two new benzo[c]phenanthridine alkaloids, 6-methyldihydrochelerythrine [1] and 6-methylnorchelerythrine [2], together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline [3], and huajiaosimuline [4], exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.
Chen
I S
IS
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
Wu
S J
SJ
Tsai
I L
IL
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D053119:Benzophenanthridines; D002454:Cell Differentiation / Q000187:drug effects; D004149:Dioxoles / Q000302:isolation & purification* / Q000494:pharmacology; D004950:Esterases / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009580:Nitroblue Tetrazolium; D010617:Phenanthridines / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D014407:Tumor Cells, Cultured
C091071:6-methyldihydrochelerythrine; C091072:6-methylnorchelerythrine; D000972:Antineoplastic Agents, Phytogenic; D053119:Benzophenanthridines; D004149:Dioxoles; D010617:Phenanthridines; D010975:Platelet Aggregation Inhibitors; D009580:Nitroblue Tetrazolium; D004950:Esterases