title: [Creutzfeldt-Jakob disease. Report of 2 cases].
abstract: The authors report two cases of Creutzfeldt Jakob disease in a 48 year old woman and a 60 year old man. This demential disorder is induced by a non conventional virus and its characterized from a clinical point of view by progressive dementia, myoclonus and seizures, it follows a subacute course with progressive deteriorization that invariably leads to death. Neuropathological features include: neuronal loss, astrocytosis and neuropil vacuolization in cortical areas of the brain. A review of the medical literature suggests that these constitute the fourth and fifth case respectively reported in Venezuela, of this unusual neurological disorder. This paper emphasizes the clinical and neuropathological features of this entity and suggests its inclussion among the differential diagnoses of the different demential processes.
authors.affiliation: Cátedra de Neuroanatomía, Facultad de Medicina, Universidad del Zulia, Venezuela.
authors.forename: O
authors.initials: O
authors.lastname: Méndez-Martínez
authors.forename: G
authors.initials: G
authors.lastname: Luzardo-Small
authors.forename: O
authors.initials: O
authors.lastname: Molina-Viloria
authors.forename: J
authors.initials: J
authors.lastname: Cardozo-Durán
mesh_terms: D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
vernacular_title: Enfermedad de Creutzfeldt-Jakob. Reporte de dos casos.