Molecular chaperones in antigen presentation.
As is the case with most proteins of the secretory pathway, the biogenesis of MHC class I and class II molecules occurs in association with molecular chaperones. Considerable progress has been made in identifying the chaperones involved and recent studies on two of these, calnexin and invariant chain, have shown that they influence multiple processes including protein stability, folding, assembly and intercellular retention.
Williams
D B
DB
Department of Biochemistry, University of Toronto, Ontario, Canada.
Watts
T H
TH
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D006801:Humans; D018832:Molecular Chaperones / Q000276:immunology*
D018832:Molecular Chaperones