Clinical studies with agents active on the 5-lipoxygenase pathway.
Leukotrienes may be considered asthmatic mediators. Compounds inhibiting their production and activity show promise in the treatment of asthma. Further clinical studies will determine the clinical usefulness of such agents.
Drazen
J
J
Combined Program in Pulmonary/Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
D001249:Asthma / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D001980:Bronchi / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D015289:Leukotrienes / Q000502:physiology; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*
D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors