title: Outcome of corneal grafting with donor tissue from eyes with primary choroidal melanomas. A retrospective cohort comparison.
abstract: OBJECTIVE
  To determine if melanomas have occurred in the recipients of corneas from donor eyes with primary choroidal melanomas and to determine the success of corneal grafting with tissue taken from eyes with primary choroidal melanomas.
  
  
  METHODS
  Retrospective cohort comparison and follow-up patient questionnaire.
  
  
  METHODS
  A tertiary medical center in Rochester, Minn.
  
  
  METHODS
  In patients who received corneal transplants, we reviewed 47 consecutive corneas transplanted from donor eyes enucleated for choroidal melanomas and compared them with 47 corneal grafts from donor eyes without melanomas matched for recipient age (+/- 10 years), date of operation (+/- 12 months), corneal storage time (+/- 24 hours), and operation type.
  
  
  RESULTS
  No melanomas occurred in either group over a mean follow-up of 5.4 years (range, 0.4 to 15 years). There was no significant difference between the two groups in corneal thickness and endothelial cell loss at 2 months and 1 year after transplantation and in the probability of a rejection episode.
  
  
  CONCLUSIONS
  There is no evidence of tumor transmission by transplantation of corneas from donor eyes with primary choroidal melanomas. Corneas transplanted from donor eyes with primary choroidal melanomas have similar outcomes to corneas transplanted from donor eyes without melanomas.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minn., USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Harrison
authors.forename: D O
authors.initials: DO
authors.lastname: Hodge
authors.forename: W M
authors.initials: WM
authors.lastname: Bourne
mesh_terms: D000328:Adult; D002423:Cause of Death; D002830:Choroid Neoplasms / Q000209:etiology / Q000473:pathology*; D015331:Cohort Studies; D003315:Cornea / Q000473:pathology; D016039:Corneal Transplantation / Q000401:mortality; D005500:Follow-Up Studies; D006801:Humans; D008545:Melanoma / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014019:Tissue Donors; D016896:Treatment Outcome