Insect antifeedant activity of clerodane diterpenoids.
Fourteen clerodane-type diterpenoids isolated from plants in the genera Baccharis, Teucrium, and Salvia were assayed for antifeedant activity against Tenebrio molitor larvae in order to establish structure-activity relationships. Among the compounds tested, furanoditerpenes with alpha, beta-unsaturated-gamma-lactone moieties, or C-4-epoxy substitution with C-5-methylacetoxy or C-12-acyloxy functionalities, exhibited maximal antifeedant and repellent activities.
Sosa
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Departamento de Bioquímica y Ciencias Biológicas, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina.
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Giordano
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D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D007302:Insect Repellents; D007814:Larva; D010944:Plants / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013712:Tenebrio / Q000187:drug effects*
D004224:Diterpenes; D007302:Insect Repellents