title: Systemic sarcoidosis initially presenting as an orbital tumour.
abstract: A 73 year old woman presented with redness, itching and painless proptosis of the left eye. Clinical examination and computed tomographic (CT) scan of the orbit revealed a postero-ocular mass, the biopsy of which showed a noncaseating, giant cellular, epithelioid granuloma compatible with sarcoidosis. The patient had no respiratory complaints, but the thoracic CT scan showed multiple bilateral hilar and mediastinal adenopathies. Gallium scan showed increased uptake in both hilar regions, in the left orbit and in the right parotid gland. Multiple bronchial biopsies revealed sarcoid granulomas, with a bronchoalveolar lavage (BAL) cytological pattern of active sarcoidosis. The evolution was favourable with prednisolone given at a dose of 0.5 mg.kg-1 daily. It is suggested that in an unusual presentation of sarcoidosis, a thorough search should be made for localization at other sites, lungs in particular, even in the absence of respiratory complaints.
authors.affiliation: Service de Pneumologie, Hôpital Civil, Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Faller
authors.forename: A
authors.initials: A
authors.lastname: Purohit
authors.forename: N
authors.initials: N
authors.lastname: Kennel
authors.forename: F
authors.initials: F
authors.lastname: de Blay
authors.forename: J
authors.initials: J
authors.lastname: Sahel
authors.forename: G
authors.initials: G
authors.lastname: Pauli
mesh_terms: D000368:Aged; D005260:Female; D006099:Granuloma / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D009916:Orbital Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D011239:Prednisolone