title: Potential radioprotective agents--V. Melatonin analogs. Oral activity of p-aminopropiophenone and its ethylene ketal.
abstract: Seven new amides of 5-methoxytryptamine were synthesized and tested for radioprotective activity in mice. One of them, the heptafluorobutyramide 4, is moderately active (57% survivors), the rest demonstrate little or no activity. Of twelve compounds that had been found to exhibit high radioprotective activity by ip injection, only two [p-aminopropiophenone (9) and its ethylene ketal 8] retain that high activity (92-95% survivors) when administered orally. Three are moderately active: p-aminobenzonitrile (10, 55%), 5-methoxytryptamine octanoic amide (11, 50%), and p-aminobenzophenone (12, 48%).
authors.affiliation: Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Blickenstaff
authors.forename: S
authors.initials: S
authors.lastname: Reddy
authors.forename: R
authors.initials: R
authors.lastname: Witt
mesh_terms: D008735:5-Methoxytryptamine / Q000737:chemistry; D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D008550:Melatonin / Q000031:analogs & derivatives*; D051379:Mice; D008815:Mice, Inbred Strains; D011427:Propiophenones / Q000737:chemistry / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000577:Amides; D011427:Propiophenones; D011837:Radiation-Protective Agents; D008735:5-Methoxytryptamine; C029564:4-aminopropiophenone; D008550:Melatonin