[The cytochrome P-450-dependent mono-oxygenase system of the liver and interleukin-1 production by the macrophages in adjuvant arthritis in rats under the influence of beta-carotene].
A relationship between the production of interleukin 1 (IL-1) by macrophages from adjuvant-induced arthritic rats and cytochrome P-450-dependent hepatic microsomal monooxygenase was studied. The synthesis of IL-1 by splenic and peritoneal macrophages on day 17 postadjuvant treatment was not altered, but the hepatic cytochrome P-450 levels and monooxygenase activity were significantly decreased. Beta-carotene treatment of arthritic rats reduced hind paw swelling and concurrently stimulated the ability of macrophages to secrete IL-1 and increased the cytochrome P-450 levels and the activity of hepatic monooxygenase. The findings did not establish a definite relationship between the production of IL-1 by systemic macrophages on the one hand, and the hepatic cytochrome P-450 levels a and monooxygenase activity on the other hand. It thus appears that IL1 is unable to play a role of a mediator between the immune system and the hepatic cytochrome P-450-dependent monooxygenase system of rats with adjuvant-induced arthritis.
Korsova
T L
TL
Potapova
A A
AA
Buiuklinskaia
O V
OV
Efimova
L V
LV
Morozova
N A
NA
Malakhova
E A
EA
Poznanskaia
A A
AA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology; D002338:Carotenoids / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D007375:Interleukin-1 / Q000096:biosynthesis*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D019207:beta Carotene
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D019207:beta Carotene; D002338:Carotenoids; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases
Tsitokhrom P-450-zavisimaia monooksigenaznaia sistema pecheni i produktsiia interleĭkina-1 makrofagami pri ad''iuvantnom artrite u krys pod vliianiem beta-karotina.