title: Incidence of venereal warts in human immunodeficiency virus-infected and uninfected women.
abstract: A cohort of human immunodeficiency virus (HIV)-infected (n = 253) and uninfected (n = 658) women was prospectively studied to assess the relationship between venereal warts and HIV status, adjusting for self-reported and biologic measures of sexual risk behavior. Participants were assessed every 6 months for venereal warts and other sexually transmitted diseases, self-reported sexual behavior, and CD4 cell counts. The incidence of venereal warts was significantly increased in HIV-infected women (8.2 vs. 0.8/100 person-years of follow-up). This difference remained after adjusting for measures of high-risk sexual behavior and was observed in women at all levels of immune function, including those with > or = 500/mm3 CD4 cells. The increased risk of venereal warts in HIV infection can occur relatively early in HIV disease and appears chiefly attributable to a higher risk of progression from subclinical to clinical human papillomavirus (HPV) disease rather than to a higher risk of HPV acquisition.
authors.affiliation: Department of Medicine, State University of New York Health Science Center at Brooklyn 11203, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Chirgwin
authors.forename: J
authors.initials: J
authors.lastname: Feldman
authors.forename: M
authors.initials: M
authors.lastname: Augenbraun
authors.forename: S
authors.initials: S
authors.lastname: Landesman
authors.forename: H
authors.initials: H
authors.lastname: Minkoff
mesh_terms: D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D017280:Condoms; D003218:Condylomata Acuminata / Q000150:complications / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D018023:HIV Seronegativity; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009519:New York City; D012307:Risk Factors; D012725:Sexual Behavior; D012749:Sexually Transmitted Diseases / Q000150:complications / Q000453:epidemiology