Leukocyte arylsulphatase A activity in acute leukemia.
Lysosomal arylsulphatase A of peripheral leukocytes from patients with acute lymphoblastic and myeloblastic leukemia and from healthy subjects, were studied. Arylsulphatase A activity of both types of leukemic cells was significantly higher than those of cells from healthy subjects. From our present observations, it can be concluded that estimation of lysosomal arylsulphatase A of leukocytes, may be of value clinically as a biochemical assay which can serve to demonstrate the presence of malignancy.
Omer
B
B
Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Capa, Turkey.
Oner
P
P
Manyasli
M
M
Aktan
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D002553:Cerebroside-Sulfatase / Q000097:blood*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000201:enzymology*; D007962:Leukocytes / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000201:enzymology*
D014408:Biomarkers, Tumor; D002553:Cerebroside-Sulfatase