Can haloperidol disguise fever?
Haloperidol when applied intraperitoneally to cold-exposed febrile rabbits induces a strong hypothermic effect. This effect is due to the downward shift of the threshold central temperature for induction of cold thermogenesis and vasomotion. The shift occurs during the early phase of the fever and is less prominent during the late phase of the fever. The hypothermic effect of high doses of haloperidol can eliminate the increase of body temperature in febrile individuals.
Vybíral
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Department of Physiology and Development Biology, Faculty of Science, Charles University, Prague, Czech Republic.
Veselá
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D000818:Animals; D001481:Basal Metabolism / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D003080:Cold Temperature; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D006220:Haloperidol / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D008070:Lipopolysaccharides / Q000494:pharmacology; D011817:Rabbits
D008070:Lipopolysaccharides; D006220:Haloperidol