Anomalous origin of the left main pulmonary artery from the ascending aorta associated with DiGeorge syndrome.
We place on record 2 infants with the DiGeorge syndrome and anomalous origin of the left pulmonary artery from the ascending aorta. We postulate that: (1) embryogenesis of anomalous origin of the left pulmonary artery from the ascending aorta might be due to the persistent fifth aortic arch connecting both arterial systems; (2) an anomalous pulmonary artery arising from the ascending aorta is part of the aortic arch abnormality accompanied by normal conotruncal septation; and (3) in the DiGeorge syndrome, cardiac anomalies that originate from the conotruncus or aortic arch, or both, may have the same embryologic mechanisms.
Dodo
H
H
Department of Pediatrics, University of California, Los Angeles, USA.
Alejos
J C
JC
Perloff
J K
JK
Laks
H
H
Drinkwater
D C
DC
Williams
R G
RG
D001011:Aorta / Q000002:abnormalities*; D001027:Aortography; D002648:Child; D004062:DiGeorge Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011651:Pulmonary Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging