Telomere shortening in chronic liver diseases.
We measured the telomere length in patients with chronic hepatitis or liver cirrhosis and found a significant telomere shortening in the liver with chronic liver disease compared to that in the normal liver. The telomere length tended to decrease with the progression of chronic liver disease.
Kitada
T
T
Department of Public Health, Osaka City University Medical School, Japan.
Seki
S
S
Kawakita
N
N
Kuroki
T
T
Monna
T
T
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001483:Base Sequence; D015139:Blotting, Southern; D005260:Female; D006505:Hepatitis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000235:genetics* / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D012016:Reference Values; D016615:Telomere / Q000473:pathology / Q000648:ultrastructure*
D015345:Oligonucleotide Probes