Fibronectin expression in the cardiovascular system.
Fibronectin (FN) is a dimeric glycoprotein found in the extracellular matrix (ECM) of most tissues and serves as a bridge between cells and the interstitial collagen meshwork. It also influences diverse processes including cell growth, adhesion, migration, and wound repair. Multiple FN forms arise by the alternative splicing of a primary transcript originating from a single gene. The spatial and temporal alterations in FN expression in the cardiovascular system have been studied in vitro in cell culture and in vivo during fetal development, hypertrophy, infarction, arterial injury and aging. This review describes characteristics of FN expression in cardiovascular system: 1. the FN phenotype is regulated during development. A high FN mRNA level is related to an early cardiac organogenesis and a progressive decrease that begins at the fetal stage and continues through senescence. During cardiac ontogeny, there is a linear correlation between total FN mRNA accumulation and the relative amounts of FN-EIIIA and EIIIB RNA. This correlation is absent during cardiac growth in the adult. 2. A differential reexpression of the FN isoforms is observed in both myocardium and aorta in different models of hypertension or infarction but with different threshold and time course. Changes in total FN mRNA levels in hypertensive models vary depending on the authors. Nevertheless the differences in the expression of the fetal forms of FN mRNA observed among the various models of hypertension-induced hypertrophy indicate that the process of FN pre-mRNA splicing in the adult myocardium is specifically regulated and depends on the pathological situations and the type of cell.(ABSTRACT TRUNCATED AT 250 WORDS)
Sabri
A
A
Unité 127 INSERM, IFR Circulation, Université D Diderot, Hôpital Lariboisiére, Paris, France.
Farhadian
F
F
Contard
F
F
Samuel
J L
JL
Rappaport
L
L
D000328:Adult; D000367:Age Factors; D000818:Animals; D006332:Cardiomegaly / Q000235:genetics*; D005260:Female; D005353:Fibronectins / Q000235:genetics*; D015870:Gene Expression; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007231:Infant, Newborn; D009203:Myocardial Infarction / Q000235:genetics*; D010641:Phenotype; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics*; D012016:Reference Values
D005353:Fibronectins; D012333:RNA, Messenger