Pulmonary capillaritis and alveolar hemorrhage associated with the antiphospholipid antibody syndrome.
Pulmonary hemorrhage due to small vessel vasculitis is a well recognized complication of many autoimmune and collagen vascular disorders. The antiphospholipid antibody syndrome (APS) is a disorder associated with hypercoagulability, thrombocytopenia, and thromboembolic phenomena. Pulmonary manifestations include pulmonary embolism, pulmonary hypertension, and respiratory failure associated with diffuse pulmonary infiltrates. We describe a patient with the APS syndrome, without systemic lupus erythematosus, who developed pulmonary hemorrhage due to pulmonary capillaritis with evidence of perivascular immune complex deposition.
Crausman
R S
RS
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80206, USA.
Achenbach
G A
GA
Pluss
W T
WT
O'Brien
R F
RF
Jennings
C A
CA
D000936:Antigen-Antibody Complex / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002196:Capillaries; D005260:Female; D006470:Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008168:Lung / Q000276:immunology / Q000473:pathology; D008171:Lung Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011650:Pulmonary Alveoli; D011652:Pulmonary Circulation; D013902:Radiography, Thoracic; D014657:Vasculitis / Q000150:complications*
D000936:Antigen-Antibody Complex