Dynamics of 5-hydroxytryptamine released from dopamine neurons in the caudate putamen of the rat.
Fast-scan cyclic voltammetry has been used for the detection of 5-hydroxytryptamine (5-HT) in vivo. The applied potential waveform was previously optimized to maximize response times to concentration changes. This technique has been used to reinvestigate 5-HT release from striatal dopaminergic terminals after pharmacological pretreatment as reported by Stamford et al. [13]. Our results concur with those set forth by Stamford and further show that the dopamine transporter is responsible for 5-HT uptake in this experiment.
Jackson
B P
BP
Department of Chemistry, University of North Carolina at Chapel Hill 27599-3290, USA.
Wightman
R M
RM
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002421:Caudate Nucleus / Q000166:cytology / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D004558:Electric Stimulation; D004594:Electrophysiology / Q000379:methods; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000378:metabolism*; D009627:Nomifensine / Q000494:pharmacology; D011699:Putamen / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D005473:Fluoxetine; D009627:Nomifensine; D012701:Serotonin; D004298:Dopamine