title: Hypothalamic hamartoma: anatomic, immunohistochemical and ultrastructural features.
abstract: Four patients with hypothalamic hamartoma were examined by CT and/or MR imaging, immunohistochemistry and electron microscopy. The hamartomas arose from the hypothalamus and extended inferiorly. LH-RH neurons were detected in three cases by immunohistochemistry. Electron microscopy revealed large myelinated axons, axon terminals containing dense-core vesicles and axon terminals with clear vesicles forming asymmetrical synapses. The development of hypothalamic hamartoma and its functional manifestations (precocious puberty and laugh attacks) are discussed in reference to the migration of LH-RH neurons from the olfactory placode.
authors.affiliation: Department of Neurosurgery, Gunma University School of Medicine.
authors.forename: H K
authors.initials: HK
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Kanazawa
authors.forename: H
authors.initials: H
authors.lastname: Kohga
authors.forename: A
authors.initials: A
authors.lastname: Zama
authors.forename: N
authors.initials: N
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: C
authors.initials: C
authors.lastname: Ohye
mesh_terms: D001369:Axons / Q000648:ultrastructure; D002675:Child, Preschool; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007027:Hypothalamic Diseases / Q000378:metabolism / Q000473:pathology*; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000737:chemistry / Q000648:ultrastructure; D017729:Presynaptic Terminals / Q000648:ultrastructure; D011629:Puberty, Precocious
chemical_list: D005904:Glial Fibrillary Acidic Protein; D007987:Gonadotropin-Releasing Hormone