title: Effect of oral captopril (SQ 14225) on intraocular pressure in man.
abstract: The effects of the angiotensin converting enzyme (ACE) inhibitor captopril (SQ 14225) on intraocular pressure (IOP) were studied. Four groups were analyzed: group A, ten control subjects; group B, ten hypertensive patients with normal IOP; group C, ten normotensive patients with primary open angle glaucoma (POAG); and group D, ten hypertensive patients with POAG. Systolic and diastolic blood pressure, heart rate, pupil diameter, IOP and total outflow facility were recorded at baseline and at 1-h intervals up to 3h after an oral dose of 25 mg captopril or placebo, given in a randomized, double-blind cross-over fashion. The alternative treatment was given a week later. Captopril significantly lowered IOP in all patients, with no effects on heart rate and pupil diameter. Blood pressure changed only in patients with hypertension (groups B and D). Total outflow facility, measured by conventional tonography, increased significantly in all groups. These findings indicate that oral captopril could represent a new antiglaucomatous compound.
authors.affiliation: Eye Clinic, 1st School of Medicine, University of Napoli, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Costagliola
authors.forename: R
authors.initials: R
authors.lastname: Di Benedetto
authors.forename: L
authors.initials: L
authors.lastname: De Caprio
authors.forename: R
authors.initials: R
authors.lastname: Verde
authors.forename: L
authors.initials: L
authors.lastname: Mastropasqua
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001082:Aqueous Humor / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy*; D011680:Pupil / Q000187:drug effects
chemical_list: D002216:Captopril