title: Resistance to activated protein C activity of an anti-beta 2-glycoprotein I antibody in the presence of beta 2-glycoprotein I.
abstract: Some researchers claim that lupus anticoagulant-positive plasma may cause a false-positive reaction in the test for activated protein C (APC) resistance, a hereditary thrombophilic state characterized by abnormal factor V, which frequently causes venous thrombosis. We investigated whether anti-beta 2-glycoprotein I antibody (aGPI), which has recently come to be regarded as an anti-cardiolipin antibody (aCL) itself, might have an effect on the APC resistance test.
authors.affiliation: Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: K
authors.initials: K
authors.lastname: Gohchi
authors.forename: K
authors.initials: K
authors.lastname: Kawasugi
authors.forename: M
authors.initials: M
authors.lastname: Tsukamoto
authors.forename: N
authors.initials: N
authors.lastname: Saitoh
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004306:Dose-Response Relationship, Immunologic; D005189:False Positive Reactions; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D011486:Protein C / Q000494:pharmacology*; D013924:Thrombophlebitis; D053482:beta 2-Glycoprotein I
chemical_list: D017153:Antibodies, Anticardiolipin; D006023:Glycoproteins; D007074:Immunoglobulin G; D011486:Protein C; D053482:beta 2-Glycoprotein I