title: Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5.
abstract: The mammalian ribosome is a massive structure composed of 4 RNA species and about 80 different proteins. One of these ribosomal proteins, S3, appears to function not only in translation but also as an endonuclease in repair of UV-induced DNA damage. Moreover, the first intron of human RPS3 transcripts is processed to generate U15A, a small nucleolar RNA. We localized the nested RPS3/U15A genes to the immediate vicinity of D11S356 and D11S533 on human chromosome 11q13.3-q13.5 using a combination of somatic cell hybrid analysis, fluorescence in situ hybridization, and YAC/STS content mapping. These findings add to the evidence that genes encoding ribosomal proteins are scattered about the human genome.
authors.affiliation: Howard Hughes Research Laboratories, Whitehead Institute, Cambridge, Massachusetts 02142, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Polakiewicz
authors.forename: D J
authors.initials: DJ
authors.lastname: Munroe
authors.forename: S N
authors.initials: SN
authors.lastname: Sait
authors.forename: K T
authors.initials: KT
authors.lastname: Tycowski
authors.forename: N J
authors.initials: NJ
authors.lastname: Nowak
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
authors.forename: D E
authors.initials: DE
authors.lastname: Housman
authors.forename: D C
authors.initials: DC
authors.lastname: Page
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002880:Chromosomes, Human, Pair 11; D006224:Cricetinae; D004260:DNA Repair / Q000235:genetics; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012342:RNA, Small Nuclear / Q000235:genetics*; D012269:Ribosomal Proteins / Q000235:genetics*
chemical_list: D012342:RNA, Small Nuclear; D012269:Ribosomal Proteins; C044152:ribosomal protein S3