[Microbiologic criteria of the choice of antibiotic for antibiotic prophylaxis in surgery].
The choice of an antibiotic for antimicrobial prophylaxis is based on microbiological, pharmacokinetic, chemical and pharmacodynamic parameters. The knowledge of the bacterial flora allows the identification of bacteria which could be responsible for postsurgical infections. These floras are complex and their equilibrium can be modified by various factors, such as hospitalization, co-existing disease, medico-surgical procedure, administration of antibiotics, which cause the selection of the so-called hospital-bacteria feared by therapists. The infection will develop according to the quantity of bacteria that have been introduced and to their virulence, which is often altered by local factors, especially the biomaterials. The knowledge of pharmacodynamic parameters such as bactericidal activity, postantibiotic effect, activity on virulence factors (bacterial adhesion), allows the refinement of the choice of the antibiotic and the optimization of its posology.
Drugeon
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Centre d'Etudes et de Recherches en Microbiologie Appliquée, Menton.
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity; D018407:Bacterial Physiological Phenomena; D005260:Female; D006801:Humans; D008297:Male; D013530:Surgical Wound Infection / Q000503:physiopathology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents
Critères microbiologiques du choix d'un antibiotique pour l'antibioprophylaxie en chirurgie.