Modulation of cytokine secretion by mesenteric lymph node cells from vitamin A-deficient mice during Hymenolepis nana infection.
The influence of vitamin A deficiency on the development of cellular immune responses was examined using vitamin A-deficient mice (A mice)/Hymenolepis nana system. Mesenteric lymph node cells (MLNC) prepared from both normal BALB/c mice and A mice during H. nana infection proliferated extensively when cultured with soluble egg antigen of H. nana as assessed by 3H-thymidine incorporation. MLNC from normal mice secreted significantly more IL-2 and significantly less IFN-gamma than A mice when the cells were cultured in the presence of soluble egg antigen.
Ikeda
K
K
Department of Medical Biology, School of Medicine, Showa University, Tokyo, Japan.
Matsuo
S
S
Asano
K
K
Okamoto
K
K
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D006925:Hymenolepiasis / Q000150:complications / Q000276:immunology*; D007371:Interferon-gamma / Q000378:metabolism*; D007376:Interleukin-2 / Q000378:metabolism*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008643:Mesentery / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D014802:Vitamin A Deficiency / Q000150:complications / Q000276:immunology*
D000947:Antigens, Helminth; D007376:Interleukin-2; D007371:Interferon-gamma