title: Increased oxygen radical and high-dietary-carbohydrate pancreatic damage.
abstract: These data suggest that an improved understanding of the relationship between high dietary carbohydrate and the rate of lipid peroxidation may give some insight into possible treatment modalities for pancreatic damages and may shed light on molecular mechanisms underlying certain pathological processes. High dietary carbohydrate lesions are age related and induced alterations on ceruloplasmin, phospholipids, total proteins, copper and zinc serum levels. Significantly increased serum and pancreatic amylase, and lipoperoxide determinations were observed in 20 month old rats. Cu-Zn superoxide dismutase was decreased in these animals. Daily injection of Cu-Zn superoxide dismutase conjugated with polyethylene glycol (SOD-PEG) prevented the serum and pancreatic changes, indicating that superoxide radical is an important intermediate to high dietary carbohydrate lesion.
authors.affiliation: Departamento de Química, Universidade Estadual Paulista e UNESP, Botucatu, Sao Paulo, Brazil.
authors.forename: E L
authors.initials: EL
authors.lastname: Novelli
authors.forename: J L
authors.initials: JL
authors.lastname: Novelli Filho
authors.forename: N L
authors.initials: NL
authors.lastname: Rodrigues
authors.forename: B O
authors.initials: BO
authors.lastname: Ribas
mesh_terms: D000818:Animals; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D010182:Pancreatic Diseases / Q000201:enzymology / Q000209:etiology*; D011092:Polyethylene Glycols / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004040:Dietary Carbohydrates; D017382:Reactive Oxygen Species; D011092:Polyethylene Glycols; D013482:Superoxide Dismutase