[The antianginal action of calcium antagonists: the results of instrumental examination and their clinical assessment].
In 88 patients with coronary heart disease and stable exercise-induced angina pectoris, the efficiency of calcium antagonists was examined by using myocardial Tl-199 scintigraphy and comparing its data with the parameters of angiography and their intracoronary injection. Three types of therapy-induced changes in myocardial perfusion were identified, which were as follows: 1) significant decreases in hypoperfusion area dimensions; 2) no changes in scintigraphic parameters, and 3) clinically asymptomatic increases in the number of hypoperfused sectors. There was a relationship between the therapy-induced changes and the number of sclerotic arteries though the ability of large coronary vessels to dilate was substantially decreased, as shown by angiopharmacological studies.
Karpov
R S
RS
Mordovin
V F
VF
Pavliukova
E N
EN
Chernov
V I
VI
Krylov
A L
AL
D000328:Adult; D000787:Angina Pectoris / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006334:Heart Function Tests / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes; D013997:Time Factors
D002121:Calcium Channel Blockers; D013794:Thallium Radioisotopes
Antianginal'noe deĭstvie antagonistov kal'tsiia: rezul'taty instrumental'nogo obsledovaniia i ikh klinicheskaia otsenka.