title: Natural course of perfused central retinal vein occlusion.
abstract: OBJECTIVE
  To investigate the visual prognosis in perfused (nonischemic) central retinal vein occlusion (CRVO), to determine the frequency of conversion from perfused to nonperfused CRVO, and to identify risk factors for poor visual outcome.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Retina referral centre in Portland, Ore.
  
  
  METHODS
  Fifty-eight patients (59 eyes) with perfused CRVO followed for at least 1 year (average 2.5 years).
  
  
  METHODS
  Visual acuity, progression to nonperfused CRVO.
  
  
  RESULTS
  At the final follow-up visit the visual acuity had improved by two or more lines in 9 eyes (15%), remained the same in 33 eyes (56%) and decreased by two or more lines in 17 eyes (29%). Factors significantly related to visual outcome were initial visual acuity (p = 0.0001) and age, older patients having a worse visual outcome (p = 0.0029). Nine eyes (15%) progressed to nonperfused CRVO. None of the factors analysed, including age, sex, duration of symptoms and initial visual acuity, were predictive of progression.
  
  
  CONCLUSIONS
  Perfused CRVO frequently results in significant, permanent visual loss, and a poor visual outcome is most likely in older patients and those with poor initial visual acuity.
authors.affiliation: Department of Ophthalmology, McGill University, Montreal, Que.
authors.forename: J C
authors.initials: JC
authors.lastname: Chen
authors.forename: M L
authors.initials: ML
authors.lastname: Klein
authors.forename: R C
authors.initials: RC
authors.lastname: Watzke
authors.forename: I L
authors.initials: IL
authors.lastname: Handelman
authors.forename: J E
authors.initials: JE
authors.lastname: Robertson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D011379:Prognosis; D012170:Retinal Vein Occlusion / Q000209:etiology* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D014785:Vision, Ocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology*