title: Regulated secretion. Helper proteins for neuroendocrine secretion.
abstract: The granins, known to be general constituents of neuroendocrine secretory granules, are regulators of the proteolytic processing of peptide precursors and promote their aggregation-mediated sorting into secretory granules.
authors.affiliation: Department of Neurobiology, University of Heidelberg, Germany.
authors.forename: W B
authors.initials: WB
authors.lastname: Huttner
authors.forename: S
authors.initials: S
authors.lastname: Natori
mesh_terms: D000818:Animals; D002460:Cell Line; D002864:Chromogranins / Q000502:physiology*; D003594:Cytoplasmic Granules / Q000502:physiology* / Q000648:ultrastructure; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D008954:Models, Biological; D009490:Neurosecretory Systems / Q000502:physiology* / Q000648:ultrastructure*; D045706:Proprotein Convertase 2; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000502:physiology*; D013381:Subtilisins / Q000378:metabolism*
chemical_list: D002864:Chromogranins; D011506:Proteins; D010450:Endopeptidases; D013381:Subtilisins; D045706:Proprotein Convertase 2