title: A bioimaging integration system implemented for neurological applications.
abstract: A system aimed at the management and fusion of multimodal biomedical images, including X-ray computed tomography, magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography, has been implemented for neurological applications. This bioimaging integration system (BIS) consists of a network for image transmission from acquisition machines to dedicated image processing workstations, a software library for image standardization, and an image registration technique to project multimodal volumetric images into a common reference space. The registration procedure was evaluated in MRI/PET correlation studies, in which misalignment errors of 2.6 mm in the xy transaxial plane and 3.4 mm along the z axis were found. BIS has been validated for the anatomical-functional correlation analysis of MRI and PET images in neurological research protocols and clinical studies.
authors.affiliation: INB-CNR, University of Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rizzo
authors.forename: M C
authors.initials: MC
authors.lastname: Gilardi
authors.forename: A
authors.initials: A
authors.lastname: Prinster
authors.forename: G
authors.initials: G
authors.lastname: Lucignani
authors.forename: V
authors.initials: V
authors.lastname: Bettinardi
authors.forename: F
authors.initials: F
authors.lastname: Triulzi
authors.forename: A
authors.initials: A
authors.lastname: Cardaioli
authors.forename: S
authors.initials: S
authors.lastname: Cerutti
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003195:Computer Communication Networks; D003952:Diagnostic Imaging; D006801:Humans; D007256:Information Systems; D008279:Magnetic Resonance Imaging; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed