Synthesis and anti-HIV activity of new urea and nitrosourea derivatives of diamino acids.
A series of N1-methyl,N1-allyl,N1-(2-chloroethyl) and N1-propargyl urea and nitrosourea derivatives of diamino acids (L-ornithine and L-lysine) was synthesized and was shown to have weak activity in counteracting the cytopathic effects of the HIV-1 on a T4 lymphocyte cell line (CEM-IW). However, selected compounds may possess some immunomodulatory activity.
Dulude
H
H
Medicinal Chemistry Laboratory, Faculty of Pharmacy, University of Montreal, Quebec, Canada.
Salvador
R
R
Gallant
G
G
D000599:Amino Acids, Diamino / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000821:virology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009603:Nitroso Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000599:Amino Acids, Diamino; D000998:Antiviral Agents; D009603:Nitroso Compounds; D014508:Urea