title: Epithelial mucin genes.
abstract: The last seven years have been exciting in the world of mucin biology. Molecular analyses of mucin genes and deduced protein structures have provided insight into structural features of mucins and tools with which to examine expression, secretion, and glycosylation, thereby enabling a better understanding of the role of mucins in normal physiological processes and in disease. Functional studies are in progress both in vitro using cDNAs and cell lines and in vivo utilizing mutant mice in which a particular mucin gene has been inactivated or overexpressed. These studies should help determine whether the functions of mucins are restricted to protection and lubrication, or if they are involved in the adhesion of tumor cells to other cells or tissue components or in modulation of the immune system.
authors.affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Arizona 85259, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Gendler
authors.forename: A P
authors.initials: AP
authors.lastname: Spicer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001980:Bronchi / Q000737:chemistry; D004848:Epithelium / Q000737:chemistry*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006801:Humans; D007422:Intestines / Q000737:chemistry; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics; D008565:Membrane Proteins / Q000737:chemistry; D008969:Molecular Sequence Data; D018396:Mucin-1; D009077:Mucins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics; D012469:Salivary Glands / Q000737:chemistry; D012795:Sialoglycoproteins / Q000235:genetics; D014132:Trachea / Q000737:chemistry
chemical_list: D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D018396:Mucin-1; D009077:Mucins; D012795:Sialoglycoproteins