title: Turing structures in a system with regulated gap-junctions.
abstract: In two coupled cells, each containing a bisubstrate-kinetics reaction system, the two substrates can cross the membranes through gap-junction protein channels (gating). Passing through the gap-junctions is controlled by one of the substrates, thus resulting in non-linear diffusion. Linear stability analysis gives the conditions, under which the symmetric fixpoint becomes unstable, leading to spatial asymmetry (Turing structures). The implications for morphogenesis are discussed.
authors.affiliation: Institute of Physical and Theoretical Chemistry, University of Tübingen, Germany.
authors.forename: C T
authors.initials: CT
authors.lastname: Klein
authors.forename: F F
authors.initials: FF
authors.lastname: Seelig
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002451:Cell Compartmentation; D004058:Diffusion; D004798:Enzymes / Q000378:metabolism; D017629:Gap Junctions / Q000378:metabolism*; D015640:Ion Channel Gating; D007700:Kinetics; D008954:Models, Biological
chemical_list: D004798:Enzymes