[The effect of para-aminobenzoic acid on the level of proliferative activity in the regenerating cornea of adult rats (a radioautographic study)].
[3H]-Thymidine radioautography showed that 0.005% p-aminobensoic acid (PABA) solution applied three times per day on penetrating wounds in central part of the adult rat cornea selectively stimulates proliferative activity of corneal stroma keratoblasts. In control rats, a curve showing changes in index of labeled nuclei in corneal stroma had two peaks, on the second and sixth day after injury (about 5 and 3%, respectively), whereas in animals receiving PABA treatment it had a single peak on the second day (about 12%). On days 7-14, indices of labeled nuclei in corneal stroma of both experimental and control rats become similarly low. No difference between experimental and control animals was revealed in indices of labeled nuclei in corneal epithelium: in both groups, corresponding curves had two peaks (about 9%) on the first and fifths days, and proliferation still continued two weeks after injury.
Sologub
A A
AA
Panova
I G
IG
Stroeva
O G
OG
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003315:Cornea / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D004728:Endothelium, Corneal / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D010129:4-Aminobenzoic Acid
Vliianie paraaminobenzoĭnoĭ kisloty na uroven' proliferativnoĭ aktivnosti v regeneriruiushcheĭ rogovitse vzroslykh krys (radioavtograficheskoe issledovanie).