title: Postoperative complications predict recurrence of Crohn's disease.
abstract: OBJECTIVE
  To find out if any of six variables influenced the incidence and timing of recurrence after a first resection for Crohn's disease.
  
  
  METHODS
  Open study.
  
  
  METHODS
  University hospital, Germany.
  
  
  METHODS
  104 surviving patients of 106 who underwent a first resection for Crohn's disease between January 1976 and December 1990.
  
  
  METHODS
  Association between 6 variables (age, sex, site of diseased bowel, histological evidence of Crohn's disease, indication for operation, and incidence of postoperative complications) and incidence and time of recurrence after the first operation.
  
  
  RESULTS
  Patients were followed up for a mean of 4.5 years (range 1-16). Presentation with acute perforation was associated with a higher incidence of recurrence (10/14 compared with 26/90), chi square 7.90, p = 0.005) and more than doubled the risk of that recurrence developing with six years (log rank chi square 11.7, p = 0.02); the same was true for development of a postoperative complication for which the corresponding figures were 14/26 compared with 22/78, chi square 4.59, p = 0.03, and log rank chi square 6.1, p = 0.01.
  
  
  CONCLUSIONS
  These data support the hypothesis that there may be two types of Crohn's disease: an aggressive type that perforates and is prone to early relapse, and one that develops more slowly with an obstructive pattern, and which relapses less often and after a longer disease free interval. The development of postoperative complications is a previously unrecognised risk factor for early recurrence in Crohn's disease.
authors.affiliation: Department of Surgery, Brigham & Women's Hospital, Boston, Massachusetts, USA.
authors.forename: R G
authors.initials: RG
authors.lastname: Holzheimer
authors.forename: R G
authors.initials: RG
authors.lastname: Molloy
authors.forename: D H
authors.initials: DH
authors.lastname: Wittmann
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D003424:Crohn Disease / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology; D008297:Male; D011183:Postoperative Complications; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate