title: Individual and combined toxicity of T-2 toxin and cyclopiazonic acid in broiler chicks.
abstract: The effects of feeding 6 mg T-2 toxin (T-2) and 34 mg cyclopiazonic acid (CPA)/kg of diet singly and in combination were characterized in male broiler chicks from 1 d to 3 wk of age. Body weights were depressed by T-2, CPA, and the combination of T-2 and CPA. There was a significant synergistic interaction between T-2 and CPA for relative liver and kidney weights and serum cholesterol and triglyceride concentrations and a significant interaction between T-2 and CPA for 3-wk body weights and relative bursa of Fabricius weights, which were less than additive. Neither the efficiency of feed utilization nor mortality was affected by dietary treatments. Oral lesions were present in a majority of the chicks fed diets containing T-2 with or without CPA. When compared with controls, other variables measured exhibited additive or less than additive toxicity. These data demonstrate that T-2 and CPA alone and in combination can cause reduced performance and adversely affect broiler health. The effects of these mycotoxins may be exacerbated by other factors when under field conditions; hence, the potential detrimental effects of these two mycotoxins when present alone or in combination cannot be dismissed.
authors.affiliation: USDA, Agricultural Research Service, Food Animal Protection Research Laboratory, College Station, Texas 77845.
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: E E
authors.initials: EE
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Gentles
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
authors.forename: T S
authors.initials: TS
authors.lastname: Edrington
authors.forename: T D
authors.initials: TD
authors.lastname: Phillips
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D002784:Cholesterol / Q000097:blood; D004357:Drug Synergism; D007211:Indoles / Q000008:administration & dosage / Q000506:poisoning*; D008297:Male; D009059:Mouth Diseases / Q000139:chemically induced; D009929:Organ Size / Q000187:drug effects; D013605:T-2 Toxin / Q000008:administration & dosage / Q000506:poisoning*; D014280:Triglycerides / Q000097:blood
chemical_list: D007211:Indoles; D014280:Triglycerides; D002784:Cholesterol; D013605:T-2 Toxin; C000543:cyclopiazonic acid