Hepatocellular adenoma in a beta-thalassemic woman having secondary iron overload.
An 18-year-old woman had a hepatocellular adenoma of 4 cm across in the right lobe of the liver which was severely hemosiderotic because of beta-thalassemia hemoglobin E disease with numerous blood transfusions. The lesion was an accidental postmortem finding. To our knowledge, this is the second example of liver-cell adenoma occurring in a patient with beta-thalassemia hemoglobin E disease with secondary iron overload. It is suggested that this is an association between hepatocellular adenoma and secondary iron overload of liver cells, a similar event to the relation observed in hepatocellular carcinoma and secondary iron overload of hepatocytes.
Shuangshoti
S
S
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Thaicharoen
A
A
D018248:Adenoma, Liver Cell / Q000209:etiology*; D000293:Adolescent; D005260:Female; D006446:Hemoglobin E / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008113:Liver Neoplasms / Q000209:etiology*; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000378:metabolism* / Q000628:therapy
D006446:Hemoglobin E; D007501:Iron