title: Vigabatrin monotherapy in resistant neonatal seizures.
abstract: Seizures in a term infant with Ohtahara syndrome, associated with polymicrogyria, and a pre-term neonate with similar clinical features, failed to respond to conventional anticonvulsants, but were controlled with vigabatrin monotherapy. Another infant with Aicardi syndrome improved with vigabatrin. Autopsy in the first infant showed no evidence of intramyelinic oedema. The developmental outcome in the two survivors was better than expected for their condition.
authors.affiliation: Department of Paediatric Neurology, Newcastle General Hospital, Newcastle-upon-Tyne, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Baxter
authors.forename: D
authors.initials: D
authors.lastname: Gardner-Medwin
authors.forename: D D
authors.initials: DD
authors.lastname: Barwick
authors.forename: P
authors.initials: P
authors.lastname: Ince
authors.forename: J
authors.initials: J
authors.lastname: Livingston
authors.forename: D
authors.initials: D
authors.lastname: Murdoch-Eaton
mesh_terms: D061085:Agenesis of Corpus Callosum; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D001284:Atrophy; D001921:Brain / Q000002:abnormalities*; D002540:Cerebral Cortex / Q000002:abnormalities / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D012008:Recurrence; D013036:Spasms, Infantile / Q000175:diagnosis / Q000188:drug therapy*; D013577:Syndrome; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000927:Anticonvulsants; D005680:gamma-Aminobutyric Acid; D020888:Vigabatrin