Central alveolar hypoventilation associated with paraneoplastic brain-stem encephalitis and anti-Hu antibodies.
We describe a patient with a paraneoplastic brain-stem encephalitis due to an occult small cell carcinoma of the lung. He developed episodes of central sleep apnoea culminating in acute respiratory failure. Antibodies resembling anti-Hu antibodies were demonstrated in both serum and cerebrospinal fluid.
Ball
J A
JA
Department of Neurology, St Mary's Hospital, London, UK.
Warner
T
T
Reid
P
P
Howard
R S
RS
Gregson
N A
NA
Rossor
M N
MN
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis*; D001933:Brain Stem; D018288:Carcinoma, Small Cell / Q000150:complications*; D002531:Cerebellum / Q000276:immunology; D051959:ELAV Proteins; D004660:Encephalitis / Q000276:immunology*; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D016601:RNA-Binding Proteins / Q000276:immunology*; D051381:Rats; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000276:immunology
D001323:Autoantibodies; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins