title: Acoustic shadowing from uterine leiomyomas: sonographic-pathologic correlation.
abstract: OBJECTIVE
  To investigate the origin of discrete shadowing from uterine leiomyomas at ultrasound (US) that does not progress from an echogenic origin.
  
  
  METHODS
  Seven hysterectomy specimens with leiomyomas were scanned in a water bath. With US guidance, 13 self-retaining needles were placed at the origin of shadows that did not (12 cases) or did (one case) arise from an echogenic focus. The localized tissues were inspected for gross pathologic features and microanatomic detail.
  
  
  RESULTS
  In the 12 cases, the shadow originated from transitional zones: the margins of the fibroid with adjacent myometrium (three needles), the edges of nodular whorls of smooth muscle (four needles), and the margin between smooth muscle bundles and hyalinized connective tissue (five needles). There was no evidence of calcification, hemorrhage, or necrosis. In the other case, microcalcifications were found.
  
  
  CONCLUSIONS
  Discrete shadowing not arising from echogenic foci resulted from the structural features of the leiomyomas and occurred at transitional boundaries between juxtaposed tissue types or at the curved margins of organized anatomic structures.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Kliewer
authors.forename: B S
authors.initials: BS
authors.lastname: Hertzberg
authors.forename: P Y
authors.initials: PY
authors.lastname: George
authors.forename: J W
authors.initials: JW
authors.lastname: McDonald
authors.forename: J D
authors.initials: JD
authors.lastname: Bowie
authors.forename: B A
authors.initials: BA
authors.lastname: Carroll
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology