Effect of sucralfate on gastric bicarbonate secretion in patients with duodenal ulcer.
BACKGROUND
Sucralfate is known to protect gastroduodenal mucosa and thereby facilitate healing of peptic ulcer. The mechanism of action of this drug is still not fully known.


METHODS
We studied the effect of sucralfate treatment on gastric bicarbonate secretion in 16 patients with duodenal ulcer.


RESULTS
Sucralfate administration (3 g daily for 4 weeks) stimulated bicarbonate secretion from 3.1 +/- 1.2 mmol/h to 4.6 +/- 2.0 mmol/h (p < 0.05). Gastric juice volume as well as non-parietal volume secretion also increased significantly after sucralfate therapy (p < 0.05).


CONCLUSIONS
Sucralfate causes stimulation of non-parietal volume-dependent gastric bicarbonate secretion.
Singh
K
K
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Nain
C K
CK
Singh
V
V
Ganguly
N K
NK
D000328:Adult; D001639:Bicarbonates / Q000378:metabolism*; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D013268:Stimulation, Chemical; D013392:Sucralfate / Q000627:therapeutic use*
D001639:Bicarbonates; D013392:Sucralfate