Sensitivity of nucleus accumbens neurons in vivo to intoxicating doses of ethanol.
The nucleus accumbens septi (NAcc) is considered an important component of the final common pathway involved in the reinforcing properties of ethanol. We studied the effects of intraperitoneal administration of ethanol on spontaneous, glutamate-activated, and fimbria-activated NAcc neurons in acute anesthetized and freely moving unanesthetized rats. Ethanol significantly reduced the firing rate of spontaneous and glutamate-activated NAcc neurons in both electrophysiological preparations. Stimulation of the ipsilateral fimbria evoked single-unit activity in NAcc neurons with two characteristic latencies (early, 7.21 +/- 0.74 msec; late, 18.24 +/- 0.66 msec). Intoxicating doses of ethanol inhibited the recruitment of late, but not of early, fimbria-activated NAcc neurons. These data demonstrate electrophysiological evidence for the existence of neurons in the core region of the NAcc that are sensitive and insensitive to acute systemic ethanol administration.
Criado
J R
JR
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA.
Lee
R S
RS
Berg
G I
GI
Henriksen
S J
SJ
D000435:Alcoholic Intoxication / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D000431:Ethanol / Q000633:toxicity; D018698:Glutamic Acid / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011999:Recruitment, Neurophysiological / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D000431:Ethanol; D018698:Glutamic Acid