Polyarthritis in HTLV-1-infected patients. A review of 17 cases.
A retrospective study was conducted in Martinique to identify patients with polyarthritis and positive serologic tests for the human T-cell lymphotropic virus Type I (HTLV-1). Patients with metabolic or bacterial causes of polyarthritis were excluded. We found 17 cases of HTLV-1-positive polyarthritis (6.7% of the total of polyarthritis patients followed in our department); there were 14 females and three males, and all the patients were West-Indian blacks. Mean age at diagnosis was 50 years. Five patients also had tropical spastic paraparesis. The polyarthritis was the inaugural manifestation of T-cell leukemia in one patient. Four patients had received blood transfusions. Fever, myalgia, and/or skin lesions were present at onset of the polyarthritis in seven cases. All 17 patients had peripheral, bilateral, symmetric polyarthritis; the most commonly involved sites were the hands (17/17) and knees (14/17). Three patients had rheumatoid factor and five had antinuclear antibody. Ten patients met at least four American Rheumatism Association criteria for rheumatoid arthritis; they accounted for 6.7% (10/150) of all polyarthritis patients managed in the same hospital department during the same period. We compared these ten patients with 20 HTLV-1-negative rheumatoid arthritis patients matched on gender, ethnic origin, and disease duration. There were no significant differences between the two groups for any of the parameters studied.
Guérin
B
B
Department of Medicine and Rheumatology, Teaching Hospital, Fort-de-France, Martinique.
Arfi
S
S
Numéric
P
P
Jean-Baptiste
G
G
Le Parc
J M
JM
Smadja
D
D
Grollier-Bois
L
L
D000328:Adult; D000368:Aged; D000937:Antigen-Antibody Reactions; D001168:Arthritis / Q000821:virology*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology / Q000821:virology; D002675:Child, Preschool; D006800:Deltaretrovirus Infections; D005260:Female; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies