Inhalation sedation with sevoflurane: a comparative study with nitrous oxide.
OBJECTIVE
To evaluate the possibility of using sevoflurane for inhalation sedation.


METHODS
Thirty-five volunteers were divided randomly into two groups: sevoflurane group (n = 20) and nitrous oxide (N2O) group (n = 15). At the beginning of the sedation they all inhaled 100% O2, then a 0.1 minimum alveolar concentration (MAC) of sevoflurane or 10% N2O with oxygen, a 0.2 MAC of sevoflurane or 20% N2O with oxygen, and 0.3 MAC of sevoflurane or 30% N2O with oxygen for 10 minutes each.


RESULTS
The respiratory and cardiovascular functions were stable during inhalation of the gas mixtures. There were five negative comments about breathing N2O, but none about breathing sevoflurane.


CONCLUSIONS
All subjects in the sevoflurane group stated they would be willing to submit to the same inhalation procedure again.
Haraguchi
N
N
1st Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
Furusawa
H
H
Takezaki
R
R
Oi
K
K
D000766:Anesthesia, Dental; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D004987:Ethers / Q000008:administration & dosage*; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000187:drug effects; D008297:Male; D008738:Methyl Ethers; D009609:Nitrous Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage; D017060:Patient Satisfaction; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane; D013990:Tidal Volume / Q000187:drug effects
D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D009609:Nitrous Oxide; D010100:Oxygen