Muscle GSH-Px activity after prolonged exercise, training, and selenium supplementation.
A double-blind study of the effects of supplementing with selenium vs. placebo on the physiological responses to acute and chronic exercise was conducted in 24 healthy, nonsmoking males, mean age 22.9 +/- 2.1 yr, randomly divided into two groups of 12 (Pla/Sel). After a controlled period in the absence of training, all subjects were put on an individualized endurance training program with the same rules of progression and overload (3 sessions/wk x 10 wk). Supplementation, either real (240 micrograms of organic selenium/d in Sel group) or imaginary (Pla group) was administered during the same period. In each of the conditions Pre- and Post- (training +/- sel supplementation), muscle, plasma, and systemic parameters were determined before (BF) and after (AF) acute exercise, involving the repetition of muscle work cycles separated by 5-min recovery periods, combining 20 min at 65% and a maximal duration of 100% VO2 max of running on a treadmill, leading the subjects to exhaustion between 2 h 40 min and 3 h 30 min. Changes in parameters as a function of three independent variables: 1. Acute exercise (E); 2. Chronic exercise (T); and 3. Selenium supplementing (S) were tested with ANOVA and the Student's t-test on paired series. Among the variables examined, muscle glutathione peroxidase (GPx) presented a remarkable behavior.(ABSTRACT TRUNCATED AT 250 WORDS)
Tessier
F
F
Laboratory of Biomechanics and Biology of Exercise, University of Nice, France.
Hida
H
H
Favier
A
A
Marconnet
P
P
D000328:Adult; D000704:Analysis of Variance; D001707:Biopsy, Needle; D015444:Exercise; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D005082:Physical Exertion; D010919:Placebos; D012643:Selenium / Q000097:blood / Q000494:pharmacology*; D014810:Vitamin E / Q000097:blood
D010919:Placebos; D014810:Vitamin E; D005979:Glutathione Peroxidase; D012643:Selenium