title: [C-reactive protein and biological defense].
abstract: This article reviews recent findings suggesting a specific tumouricidal effect of C-reactive protein (CRP). A peptidic fragment of CRP, called RS 83277, has shown a significant anti-tumour effect in laboratory animals. The mechanism is not fully understood, but is possibly mediated via the macrophages. Both macrophages and monocytes show increased tumoricidal activity after stimulation with RS 83277. The article also reviews the regulation of CRP synthesis and secretion, as well as the structure, binding capacities, and important biological properties of CRP.
authors.affiliation: Kirurgisk avdeling B, Rikshospitalet, Oslo.
authors.forename: E M
authors.initials: EM
authors.lastname: Hennig
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001665:Binding Sites; D002097:C-Reactive Protein / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C079718:RS 83277; D002097:C-Reactive Protein
vernacular_title: C-reaktivt protein og biologisk forsvar.