title: Epidermal carcinogenesis studies of EDS liquids.
abstract: A series of liquids representing different potential design options or operating configurations for the EDS direct coal liquefaction process* were evaluated for skin cancer potential. All of the samples that contained substantial amounts of material boiling above 370 degrees C were active dermal carcinogens; tumor yields were near 100% and median times to tumor development generally ranged from 30 to 40 weeks. Two liquids that boiled below ca. 200 degrees C were tested and each produced one squamous cell tumor. These data suggested that high-boiling-point, coal-derived liquids are likely to be relatively potent dermal carcinogens; whereas low-boiling-point liquids do not possess significant carcinogenic potential. Based on a comparison of the carcinogenic potency data, liquids produced by the EDS process apparently do not present a significantly greater dermal carcinogenic hazard than other coal-derived materials of similar boiling range.
authors.affiliation: Exxon Biomedical Sciences, Inc., East Millstone, NJ 08875-2350, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: McKee
authors.forename: R T
authors.initials: RT
authors.lastname: Plutnick
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D002274:Carcinogens, Environmental; D003031:Coal / Q000633:toxicity*; D005648:Fuel Oils / Q000633:toxicity; D006358:Hot Temperature; D008297:Male; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced*; D013638:Tars / Q000633:toxicity
chemical_list: D002274:Carcinogens, Environmental; D003031:Coal; D005648:Fuel Oils; D013638:Tars