USF-19A, a new lipoxygenase inhibitor from Streptomyces sp.
USF-19A, a soybean lipoxygenase (SBL) and human 5-lipoxygenase (5-LO) inhibitor, was isolated from Streptomyces sp. USF-19 strain. Its chemical structure was determined by spectroscopic evidence to be a new member of the antimycin antibiotic family. The IC50 value of USF-19A against 5-LO was 28.0 microM.
Komoda
T
T
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Morimitsu
Y
Y
Hirota
H
H
Hirota
A
A
D001549:Benzamides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012988:Soil Microbiology; D013025:Glycine max / Q000201:enzymology; D013302:Streptomyces / Q000737:chemistry* / Q000201:enzymology*
D001549:Benzamides; D007783:Lactones; D016859:Lipoxygenase Inhibitors; C094259:USF 19A