title: Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice.
abstract: Ciliary neurotrophic factor (CNTF) supports the survival of ciliary ganglion neurons and was shown to induce the synthesis of acute-phase proteins and fever. We studied the effect of CNTF, alone or in association with IL-1, on levels of corticosterone (CS), glucose, serum amyloid A (SAA), and IL-6. We also compared the effect of CNTF with that of IL-6, since the gp130 receptor subunit for CNTF is shared with that of IL-6. A single intravenous injection of CNTF induced hypoglycaemia and SAA and potentiated IL-1-induced CS and IL-6. Chronic CNTF, but not IL-6, resulted in decreased food intake and body weight up to days 6-7. After this time, body weight and food intake recovered even if CNTF treatment was continued, indicating that a phenomenon of tolerance occurred. Finally, CNTF (unlike IL-1) was not toxic in adrenalectomized mice. Therefore the similarities of CNTF activities with those of other cytokines, particularly IL-6, might go beyond the activation of the same receptor-signal transduction pathway of IL-6.
authors.affiliation: Mario Negri Institute for Pharmacological Research, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fantuzzi
authors.forename: F
authors.initials: F
authors.lastname: Benigni
authors.forename: M
authors.initials: M
authors.lastname: Sironi
authors.forename: M
authors.initials: M
authors.lastname: Conni
authors.forename: M
authors.initials: M
authors.lastname: Carelli
authors.forename: L
authors.initials: L
authors.lastname: Cantoni
authors.forename: L
authors.initials: L
authors.lastname: Shapiro
authors.forename: C A
authors.initials: CA
authors.lastname: Dinarello
authors.forename: J D
authors.initials: JD
authors.lastname: Sipe
authors.forename: P
authors.initials: P
authors.lastname: Ghezzi
mesh_terms: D000818:Animals; D000855:Anorexia / Q000139:chemically induced*; D001681:Biological Assay; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D020934:Ciliary Neurotrophic Factor; D003345:Corticosterone / Q000096:biosynthesis*; D004357:Drug Synergism; D004361:Drug Tolerance; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology; D000685:Serum Amyloid A Protein / Q000096:biosynthesis*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D020934:Ciliary Neurotrophic Factor; D007375:Interleukin-1; D015850:Interleukin-6; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D000685:Serum Amyloid A Protein; D003345:Corticosterone