title: [The principles for creating drug preparations of natural origin that stimulate hematopoiesis].
abstract: The paper outlines the principles in designing hemostimulators by using glycosamineglycans. Hemostimulating properties of the tested agents is likely to be primarily due to the presence of D-glucuronic acid in their structure. The homotypic mechanisms are largely responsible for all agents' effect in stimulating hemopoiesis. Thus, they all virtually activate the function of the hemopoiesis-inducing microenvironment. In addition, they directly or indirectly stimulate the processes of proliferation and differentiation of precursor cells of erythro- and granulomonocytopoiesis.
authors.forename: E D
authors.initials: ED
authors.lastname: Gol'dberg
authors.forename: A M
authors.initials: AM
authors.lastname: Dygaĭ
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
authors.forename: S G
authors.initials: SG
authors.lastname: Aksinenko
authors.forename: V E
authors.initials: VE
authors.lastname: Gol'dberg
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: V I
authors.initials: VI
authors.lastname: Litvinenko
authors.forename: P A
authors.initials: PA
authors.lastname: Liubavina
authors.forename: M G
authors.initials: MG
authors.lastname: Matiash
authors.forename: E V
authors.initials: EV
authors.lastname: Novitskiĭ
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D015195:Drug Design; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship
chemical_list: D006025:Glycosaminoglycans; D010936:Plant Extracts
vernacular_title: Printsipy sozdaniia lekarstvennykh preparatov--stimuliatorov krovetvoreniia prirodnogo proiskhozhdeniia.