title: Structure-function interrelation and clinical effect of atrial natriuretic peptide (ANP).
abstract: Atriopeptin III (AP III) and its six analogues were synthesized by solid phase method and their diuretic and hypotensive activities were determined. Among these analogues, analogue [D-Ala-5, D-Arg-23] AP III was nearly 10 times as potent as AP III in diuretic activity while its hypotensive activity increased only 50% of that of AP III. Analogue des [Ser-15Gly-16Leu-17Gly-18Asn-20Ser-21] AP III was 15% as potent as AP III in diuretic activity, but it still maintained about 60% of the hypotensive activity of AP III. Meanwhile, we tried analogue [D-Ala-5, D-Agr-23] AP III for the treatment of hypertensive syndrome in pregnancy and obtained some good results.
authors.affiliation: Shanghai Institute of Biochemistry, Academia Sinica.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Shi
mesh_terms: D000328:Adult; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004232:Diuretics / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008968:Molecular Conformation; D010446:Peptide Fragments; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D010446:Peptide Fragments; C062525:atrial natriuretic factor prohormone (103-126); D009320:Atrial Natriuretic Factor