title: Pulmonary capillaritis and alveolar hemorrhage associated with the antiphospholipid antibody syndrome.
abstract: Pulmonary hemorrhage due to small vessel vasculitis is a well recognized complication of many autoimmune and collagen vascular disorders. The antiphospholipid antibody syndrome (APS) is a disorder associated with hypercoagulability, thrombocytopenia, and thromboembolic phenomena. Pulmonary manifestations include pulmonary embolism, pulmonary hypertension, and respiratory failure associated with diffuse pulmonary infiltrates. We describe a patient with the APS syndrome, without systemic lupus erythematosus, who developed pulmonary hemorrhage due to pulmonary capillaritis with evidence of perivascular immune complex deposition.
authors.affiliation: Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80206, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Crausman
authors.forename: G A
authors.initials: GA
authors.lastname: Achenbach
authors.forename: W T
authors.initials: WT
authors.lastname: Pluss
authors.forename: R F
authors.initials: RF
authors.lastname: O'Brien
authors.forename: C A
authors.initials: CA
authors.lastname: Jennings
mesh_terms: D000936:Antigen-Antibody Complex / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002196:Capillaries; D005260:Female; D006470:Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008168:Lung / Q000276:immunology / Q000473:pathology; D008171:Lung Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011650:Pulmonary Alveoli; D011652:Pulmonary Circulation; D013902:Radiography, Thoracic; D014657:Vasculitis / Q000150:complications*
chemical_list: D000936:Antigen-Antibody Complex