[The cholesterol esterase activity of the blood monocytes and alveolar macrophages in patients with chronic bronchitis].
The activity of cholesterol esterase (CE) in blood monocytes and alveolar macrophages (AMF) of bronchoalveolar fluid (BAF) according to Brecher et al., cell composition of endobronchial cytogram were investigated in 32 patients with chronic bronchitis (CB) and control subjects. In CB sufferers CE activity in AMF was inhibited, while in monocytes it was elevated reaching maximal values in purulent bronchopulmonary CB. Determination of CE activity in AMF and peripheral blood monocytes in CB may serve an additional diagnostic indicator of impaired lipid metabolism and suggests new approaches to investigation of CB pathogenesis.
Sidorova
L D
LD
Shakalite
Iu D
IuD
Logvinenko
A S
AS
Kuznetsov
P O
PO
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001991:Bronchitis / Q000201:enzymology* / Q000209:etiology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002908:Chronic Disease; D006801:Humans; D016676:Macrophages, Alveolar / Q000201:enzymology*; D008297:Male; D009000:Monocytes / Q000201:enzymology*; D011379:Prognosis; D002787:Sterol Esterase / Q000032:analysis*
D015415:Biomarkers; D002787:Sterol Esterase
Aktivnost kholesterinésterazy monotsitov krovi i al'veoliarnykh makrofagovu bol'nykh khronicheskim bronkhitom.