Randomized double-blind study comparing the efficacy of terazosin versus placebo in women with prostatism-like symptoms.
OBJECTIVE
We attempt to determine whether terazosin is effective therapy for the treatment of prostatism-like symptoms in women.


METHODS
A total of 29 women 47 to 79 years old with prostatism-like symptoms entered a randomized double-blind study comparing terazosin (14) versus placebo (15). The salient inclusion and exclusion criteria consisted of an American Urological Association (AUA) symptom score of 8 or more, post-void residual volume less than 300 ml. and absence of stress urinary incontinence.


RESULTS
The baseline and final visit AUA symptom scores were 12.7 and 10.7 respectively, in the placebo group, and 16.4 and 13.6, respectively, in the terazosin group. The differences between the change in AUA symptom score in the placebo and terazosin groups were not clinically or statistically significant.


CONCLUSIONS
Our study demonstrates that terazosin is not effective for the treatment of prostatism-like symptoms in aging women.
Lepor
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H
Department of Urology, New York University School of Medicine, New York, USA.
Theune
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D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D004244:Dizziness / Q000139:chemically induced; D004311:Double-Blind Method; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D010919:Placebos; D011224:Prazosin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000139:chemically induced; D014555:Urination Disorders / Q000188:drug therapy*
D000317:Adrenergic alpha-Antagonists; D010919:Placebos; C041226:Terazosin; D011224:Prazosin