Bronchiectasis and homozygous (P1ZZ) alpha 1-antitrypsin deficiency in a young man.
Pulmonary complications of alpha 1-antitrypsin deficiency are most commonly manifested by panlobular emphysema. This report describes histologically proven bronchiectasis in a 21 year old man with massive haemoptysis and homozygous deficiency of alpha 1-antitrypsin. Neither panlobular emphysema nor cirrhosis of the liver were present. Bronchiectasis must be considered part of the spectrum of the pulmonary pathology that may be encountered in individuals with alpha 1-antitrypsin deficiency.
Rodriguez-Cintron
W
W
Department of Pulmonary Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Guntupalli
K
K
Fraire
A E
AE
D000328:Adult; D001987:Bronchiectasis / Q000209:etiology* / Q000473:pathology; D006469:Hemoptysis / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D010641:Phenotype; D019896:alpha 1-Antitrypsin Deficiency