Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.
The murine Unp proto-oncogene encodes a nuclear ubiquitin protease whose overexpression leads to oncogenic transformation of NIH3T3 cells. We have cloned cDNAs originating from the human homolog of this gene, designated herein as Unph (Unp, human), and have used these cDNAs to map the gene to 3p21.3, a region frequently rearranged in human tumor cells. Unph mRNA levels are consistently elevated in small cell tumors and adenocarcinomas of the lung, suggesting a possible causative role for the gene in the neoplastic process.
Gray
D A
DA
Department of Medicine, University of Ottawa, Canada.
Inazawa
J
J
Gupta
K
K
Wong
A
A
Ueda
R
R
Takahashi
T
T
D016475:3T3 Cells; D000230:Adenocarcinoma / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018288:Carcinoma, Small Cell / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3; D018076:DNA, Complementary; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D015513:Oncogene Proteins / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D017386:Sequence Homology, Amino Acid; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases
D018076:DNA, Complementary; C000715470:MAS1 protein, human; D015513:Oncogene Proteins; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; C486203:USP4 protein, human; C082325:Usp4 protein, mouse; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases