Antitumor and cardiotonic activity of imidazo[2,1-b]thiazole guanylhydrazones.
A number of imidazo[2,1-b]thiazole guanylhydrazones, whose antitumor activity has already been described, were tested as potential cardiotonic agents. The guanylhydrazone of 2,3-dihydro-6-chloroimidazo[2,1-b]thiazole-5-carboxaldehyde (2a) was the most interesting compound showing both antitumor and cardiotonic activity.
Andreani
A
A
Dipartimento di Scienze Farmaceutiche dell'Universita, Bologna, Italy.
Rambaldi
M
M
Locatelli
A
A
Bossa
R
R
Galatulas
I
I
Salvatore
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D006835:Hydrazones / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D015394:Molecular Structure
D000970:Antineoplastic Agents; D002316:Cardiotonic Agents; D006835:Hydrazones; D007093:Imidazoles