Neuropsychiatry and SPECT of an acute obsessive-compulsive syndrome patient.
BACKGROUND
A 71-year-old man with no previous psychiatric history presented with an acute onset of obsessive-compulsive disorder (OCD) symptoms associated with a right inferior parietal infarct. There were no abnormal neurological signs. There were no noteworthy abnormalities on neuropsychological testing.


METHODS
Whereas a computerised tomography scan showed only a right inferior parietal infarct, a single photon emission computerised tomography (SPECT) scan revealed that in addition to the infarct there was decreased regional cerebral blood flow in the right basal ganglia and temporal areas. There was higher activity in the right orbitofrontal area than in the left.


RESULTS
The patient improved with standard drug therapy and psychotherapy.


CONCLUSIONS
SPECT is effective in the diagnosis of neuropsychiatric disorders such as OCD, and the pathological changes in brain metabolism detected by SPECT may be reversed by both drug therapy and psychotherapy.
Simpson
S
S
Manchester Royal Infirmary.
Baldwin
B
B
D000368:Aged; D001921:Brain / Q000098:blood supply; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology; D019965:Neurocognitive Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology; D012039:Regional Blood Flow / Q000502:physiology; D013850:Thinking / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon