[19F-MR imaging of transplanted tumor: perfluorochemicals as a fluorine tumor imaging agent].
OBJECTIVE
The purpose of our study was to detect tumor selectively using 19F-magnetic resonance imaging (MRI) and to assess Fluosol-DA, a perfluorochemical emulsion, as a tumor imaging agent for 19F-MRI.


METHODS
SCC VII cells were transplanted in the right leg of mice. After 6 days, Fluosol-DA was administrated intravenously (40 ml/kg). 19F-MR imaging was performed on a Bruker CSI Omega 2 at 4.7 Tesla using a homemade volume coil.


RESULTS
In vitro, the concentration and 19F signal intensity of FDA showed a very high correlation (r = 0.9997). Detection on MRI was possible at a concentration of 2%. In vivo, images of 19F in SCC VII tumors were achieved in animals 2 days after the administration of FDA.


CONCLUSIONS
Our study confirms the feasibility of 19F-MR in vivo imaging of tumors using the fluorine compound FDA.
Itoh
Y H
YH
Department of Radiology, Aichi Medical University.
Kandori
Y
Y
Takahashi
M
M
Fritz-Zieroth
B
B
Miyata
N
N
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D004338:Drug Combinations; D005260:Female; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D008279:Magnetic Resonance Imaging; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination