Genetics in cancer prediction, screening, and counseling: Part I, Genetics in cancer prediction and screening.
OBJECTIVE
To review molecular biology and gene technology as they relate to cancer prediction and screening.


METHODS
Published professional articles, texts, and proceedings; computerized data bases.


RESULTS
Basic principles of inheritance and mutations; a discussion of proto-oncogenes, oncogenes, and anti-oncogenes; a summary of gene-mapping techniques; and a review of genes linked to familial, breast, ovarian, and colorectal cancers.


CONCLUSIONS
Most human cancers are influenced genetically but are not inherited. Discoveries about cancer genes play a major role in identifying individuals and families who are likely to develop cancer.


CONCLUSIONS
Nurses need to heighten their awareness of this science and its ramifications, which ultimately will affect recommendations for early detection and screening.
Loescher
L J
LJ
University of Arizona, Arizona Cancer Center, Tucson, USA.
D016147:Genes, Tumor Suppressor; D005817:Genetic Counseling; D006801:Humans; D008403:Mass Screening; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000451:nursing / Q000517:prevention & control; D009857:Oncogenes; D011379:Prognosis