Changes in circulating immune complex and charge distribution with upper respiratory tract inflammation in IgA nephropathy.
The circulating IgA class immune complex (IgA-IC) and its charge distribution, at the appearance of macroscopic hematuria and after tonsillectomy in patients with IgA nephropathy, were investigated in the present study. 3.5% polyethylene glycol precipitate (3.5% PEG-IgA) was used for IgA-IC detection and isoelectric focusing for its charge distribution. The level of IgA in 3.5% PEG-IgA, principally IgA1, and the proportion of anionic 3.5% PEG-IgA (isoelectric point, pl, 4.8-5.6) were significantly elevated in episodes of macroscopic hematuria with upper respiratory tract inflammation and with the appearance of macroscopic hematuria 1 day after tonsillectomy. Therefore, an increase in anionic IgA-IC (pl 4.8-5.6), principally IgA1, and the tonsils were considered to be concerned with the mechanism involved in the appearance of macroscopic hematuria.
Yamaguchi
K
K
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Ozono
Y
Y
Harada
T
T
Hara
K
K
D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000276:immunology*; D006417:Hematuria / Q000150:complications / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000737:chemistry / Q000145:classification; D007249:Inflammation / Q000150:complications / Q000276:immunology; D007526:Isoelectric Point; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D012140:Respiratory Tract Diseases / Q000150:complications* / Q000276:immunology*; D014068:Tonsillectomy
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D011092:Polyethylene Glycols