Effects of alpha,beta-unsaturated sulphones and phosphonium salts on ecto-ATPase activity and contractile responses mediated via P2 chi-purinoceptors.
1. In the guinea-pig urinary bladder and vas deferens, several alpha,beta-unsaturated sulphones and phosphonium salts that were tested inhibited ecto-ATPase activity. The sulphones were more active in the bladder but the phosphonium salts were more effective in the vas deferens. 2. These compounds either potentiated or inhibited purinergic contractile responses in the guinea-pig urinary bladder and vas deferens. 3. alpha,beta-Unsaturated sulphones and phosphonium salts represent a new promising class of compounds, capable of modulating purinergic neurotransmission.
Ziganshin
A U
AU
Department of Anatomy and Developmental Biology, University College London, U.K.
Berdnikov
E A
EA
Ziganshina
L E
LE
Tantasheva
F R
FR
Hoyle
C H
CH
Burnstock
G
G
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D018048:Receptors, Purinergic P2 / Q000187:drug effects*; D013450:Sulfones / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects / Q000201:enzymology; D014649:Vas Deferens / Q000187:drug effects / Q000201:enzymology
D009943:Organophosphorus Compounds; D018048:Receptors, Purinergic P2; D013450:Sulfones; D000251:Adenosine Triphosphatases; C027201:ectoATPase