Immunochemical characterisation of megakaryocyte potentiator activity from mouse bone marrow.
Megakaryocyte potentiator derived from mouse bone marrow has been shown to be immunologically similar to Interleukin-6 (IL-6). In this study the activity has been characterised by biochemical and immunochemical techniques. The activity is described as a O-linked glycosylated molecule with an apparent MW of 15 Kd and pl of the range pH 5.9-6.35. The data show that mouse bone marrow potentiator activity is a variant of IL-6 and with the potential to enhance megakaryocyte growth.
Banu
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Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
Williams
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D000818:Animals; D001671:Biochemistry / Q000379:methods; D001853:Bone Marrow / Q000378:metabolism*; D058851:GPI-Linked Proteins; D007120:Immunochemistry / Q000379:methods; D015850:Interleukin-6 / Q000737:chemistry / Q000276:immunology; D008533:Megakaryocytes / Q000502:physiology; D008562:Membrane Glycoproteins; D000090204:Mesothelin; D051379:Mice; D011506:Proteins / Q000737:chemistry* / Q000276:immunology* / Q000502:physiology
D058851:GPI-Linked Proteins; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D011506:Proteins; D000090204:Mesothelin