neu overexpression correlates with extent of disease in large cell ductal carcinoma in situ of the breast.
In a retrospective study of ductal carcinoma in situ (DCIS) of the breast, the expression of the neu oncogene was determined immunohistochemically in 76 women treated by local excision or mastectomy. The histopathological features, including the extent of the lesion, histological subtype, cell type, and number of mitoses, were related to neu overexpression. Immunopositivity was found only in DCIS of large cell type, where it correlated with extent of disease but not with mitotic rate. Our findings, together with previous experimental evidence, suggest that this relationship is a consequence of the effect of the neu protein on cell motility.
De Potter
C R
CR
N. Goormaghtigh Institute of Pathology, University Hospital, Ghent, Belgium.
Schelfhout
A M
AM
Verbeeck
P
P
Lakhani
S R
SR
Brünken
R
R
Schroeter
C A
CA
Van den Tweel
J G
JG
Schauer
A J
AJ
Sloane
J P
JP
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D002278:Carcinoma in Situ / Q000378:metabolism* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology*; D018287:Carcinoma, Large Cell / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D012189:Retrospective Studies
D018719:Erb-b2 Receptor Tyrosine Kinases