title: Very accelerated radiation therapy: preliminary results in locally unresectable head and neck carcinomas.
abstract: OBJECTIVE
  To report preliminary results of a very accelerated radiation therapy Phase I/II trial in locally advanced head and squamous cell carcinomas (HNSCC).
  
  
  METHODS
  Between 01/92 and 06/93, 35 patients with an unresectable HNSCC were entered in this study. Thirty-two (91%) had Stage IV, and 3 had Stage III disease. The mean nodal diameter, in patients with clinically involved nodes (83%), was 6.3 cm. The median Karnovsky performance status was 70. The treatment consisted of a twice daily schedule (BID) giving 62 Gy in 20 days.
  
  
  RESULTS
  In all cases, confluent mucositis was observed, which started about day 15 and resolved within 6 to 10 weeks. Eighty percent of patients had enteral nutritional support. The nasogastric tube or gastrostomy was maintained in these patients for a mean duration of 51.8 days. Eighteen patients (53%) were hospitalized during the course of treatment due to a poor medical status or because they lived far from the center (mean 25 days). Nineteen patients (56%) (some of whom were initially in-patients) were hospitalized posttreatment for toxicity (mean 13 days). Five patients (15%) were never hospitalized. During the follow-up period, 12 local and/or regional failures were observed. The actuarial 18-month loco-regional control rate was 59% (95% confidence interval, 45-73%).
  
  
  CONCLUSIONS
  The dramatic shortening of radiation therapy compared to conventional schedules in our series of very advanced HNSCC resulted in: (a) severe acute mucosal toxicity, which was manageable but required intensive nutritional support in all cases; and (b) high loco-regional response rates, strongly suggesting that the time factor is likely to be critical for tumor control in this type of cancer.
authors.affiliation: Institut Gustave Roussy, Villejuif, France.
authors.forename: J
authors.initials: J
authors.lastname: Bourhis
authors.forename: A
authors.initials: A
authors.lastname: Fortin
authors.forename: O
authors.initials: O
authors.lastname: Dupuis
authors.forename: C
authors.initials: C
authors.lastname: Domenge
authors.forename: A
authors.initials: A
authors.lastname: Lusinchi
authors.forename: P
authors.initials: P
authors.lastname: Marandas
authors.forename: G
authors.initials: G
authors.lastname: Schwaab
authors.forename: J P
authors.initials: JP
authors.lastname: Armand
authors.forename: B
authors.initials: B
authors.lastname: Luboinski
authors.forename: E
authors.initials: E
authors.lastname: Malaise
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011014:Pneumonia / Q000209:etiology; D011879:Radiotherapy Dosage; D013280:Stomatitis / Q000209:etiology