[The pharmacological correction of the activity of lipid peroxidation processes in the dynamics of craniocerebral trauma].
Rat experiments have shown that free radical oxidation processes are activated in the cerebral mitochondrial fraction in the dynamics of craniocerebral injury, which appears as accumulation of malonic dialdehyde and disturbed functional interaction of antiradical protection enzymes. These changes are most marked 24 hours after injury. Some GABA-positive drugs and opioid receptor agonists prevent lipid peroxidation activation. The highest efficiency is displayed by piracetam (1 g/kg) and the synthetic enkephalin analogue DSLET (0.1 mg/kg).
Novikov
V E
VE
Iasnetsov
V V
VV
Evseev
A V
AV
Merkulova
L I
LI
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005260:Female; D018755:GABA Agonists / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011957:Receptors, Opioid / Q000819:agonists; D013997:Time Factors
D018755:GABA Agonists; D011957:Receptors, Opioid
Farmakologicheskaia korrektsiia aktivnosti protsessov perekisnogo okisleniia lipidov v dinamike cherepno-mozgovoĭ travmy.