title: Acute lung injury in lung allografts.
abstract: BACKGROUND
  Acute alveolar injury is a pathologic description of a nonspecific response of the lung to an acute injury. It has been our experience that acute alveolar injury may be seen in transbronchial biopsy and open lung biopsy specimens from patients who have successfully undergone lung transplantation. Because no studies of the clinical significance of acute alveolar injury in lung transplant recipients are available in the literature, we reviewed the impact of this pathologic finding in patients who underwent transplantation in the Toronto Lung Transplant Program.
  
  
  METHODS
  From November 1983 through December 1992, we retrospectively reviewed all transbronchial biopsies and open lung biopsies performed in lung transplant recipients.
  
  
  RESULTS
  Of the 137 transplantations performed (53 single and 84 double) acute alveolar injury was observed in 21 single (34 of 173 transbronchial biopsy and 3 of 11 open lung biopsy) lung biopsy) and 22 double (38 of 415 transbronchial biopsy and 3 of 11 open lung biopsy) lung transplantations. We sought to explain this finding on the basis of the concurrent clinical scenario. Acute alveolar injury occurred most commonly in association with infection (52%) followed by postoperative period (19%) and acute (16%) rejection. Acute alveolar injury occurred as an isolated finding in 7% of patients. It occurred within the first 4 months after transplantation in 80% of cases. In 10 of 21 single lung transplantations and 12 of 22 double lung transplantations, acute alveolar injury was seen at least twice. However, no difference was found in mortality between such patients (6 of 10 single and 6 of 12 double lung transplantations) and patients with only one episode of acute alveolar injury.
  
  
  CONCLUSIONS
  Acute alveolar injury is a relatively common finding in histologic specimens from patients with lung transplantation and is most commonly associated with infection.
authors.affiliation: Department of Medicine, Toronto Hospital, University of Toronto, Ontario, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Chaparro
authors.forename: D
authors.initials: D
authors.lastname: Chamberlain
authors.forename: J
authors.initials: J
authors.lastname: Maurer
authors.forename: A
authors.initials: A
authors.lastname: De Hoyos
authors.forename: T
authors.initials: T
authors.lastname: Winton
authors.forename: S
authors.initials: S
authors.lastname: Kesten
mesh_terms: D001706:Biopsy; D001989:Bronchiolitis Obliterans / Q000473:pathology; D006084:Graft Rejection / Q000473:pathology; D006801:Humans; D007165:Immunosuppression Therapy; D008171:Lung Diseases / Q000382:microbiology / Q000469:parasitology / Q000473:pathology*; D016040:Lung Transplantation / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors