[The search for new antiparasitic agents. 12. The synthesis and study of the anti-Echinococcus and anti-Hymenolepis activity of 6-[4-(4-alkylpiperazinyl-1)-phenylamino]-1,2,5-thiadazolo[3 ,4-h] quinolines].
The paper describes the synthesis of 6-[4-alkylpiperazinyl-1)phenylamino]-1,2,5-thiadiazolo[3,4-h ]quinolines where methyl (Drug G-1574) and ethyl (Drug G-1569) are alkyls. The two agents are as effective as mebendazole against the larval stage of Echinococcus multilocularis infection. Drug G-1574 has been demonstrated to ensure 100% recovery of spontaneously Hymenolepis nana-infected albino mice given doses 2.5-5 times lower than the effective dose of phenasal (niclosamide).
Mikhaĭlitsyn
F S
FS
Kovalenko
F P
FP
Kozyreva
N P
NP
Dzhabarova
V I
VI
Lebedeva
M N
MN
Lychko
N D
ND
Naĭdenova
A S
AS
Uvarova
N A
NA
D000818:Animals; D000923:Anticestodal Agents / Q000138:chemical synthesis* / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D006925:Hymenolepiasis / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D051379:Mice; D009534:Niclosamide / Q000627:therapeutic use; D011804:Quinolines / Q000138:chemical synthesis* / Q000627:therapeutic use* / Q000633:toxicity; D016205:Sigmodontinae
D000923:Anticestodal Agents; D011804:Quinolines; D008463:Mebendazole; D009534:Niclosamide
Izyskanie novykh protivoparazitarnykh sredstv. 12. Sintez i izuchenie protivoékhinokokkoznoĭ i protivogimenolepidoznoĭ aktivnosti 6-[4-(4-alkilpiperazinil-1)-fenilamino]-1,2,5-tiadiazolo[3,4-h] khinolinov.