Mutants of dermatophytes resistant to ketoconazole.
Authors describe the frequency and properties of mutants resistant to ketoconazole, obtained from the dermatophytes Microsporum gypseum and Trichophyton mentagrophytes. Spontaneous mutants occurred with the frequency of 10(-9) to spore and nucleus. Ultraviolet radiation increased the frequency of mutants by two numeric orders. The resistance level was relatively small in both types of mutants (RL within the range of 2-5).
Lenhart
K
K
Institute of Biology, Medical faculty Olomouc, Czech Republic.
Merkunová
A
A
D004352:Drug Resistance, Microbial; D007654:Ketoconazole / Q000494:pharmacology*; D008864:Microsporum / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D014249:Trichophyton / Q000187:drug effects* / Q000235:genetics
D007654:Ketoconazole