title: Spontaneous osteosarcoma of the meninges in an albino rat.
abstract: A search of the rat tumor literature revealed no papers on naturally occurring primary osteosarcoma of meninges. In humans, this tumor, arising primarily from the meninges, is unusual; only two cases have been reported. We report on a spontaneously occurring osteosarcoma arising from meninges in a 2-year-old female albino rat. The diagnosis was made on the basis of gross, microscopic, and ultrastructural findings. The diagnosis of this neoplasm is supported by the fact that a primitive mesenchymal cell in the meninges is capable of giving rise to a wide variety of neoplasms.
authors.affiliation: Ciba-Geigy, Ltd., Basle, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Pace
authors.forename: E
authors.initials: E
authors.lastname: Persohn
authors.forename: K
authors.initials: K
authors.lastname: Heider
mesh_terms: D000818:Animals; D005260:Female; D008577:Meningeal Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D008854:Microscopy, Electron / Q000662:veterinary; D012516:Osteosarcoma / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D051381:Rats; D017207:Rats, Sprague-Dawley