title: Isomer-specific analysis of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEQs) in red fox and human adipose tissue from central Italy.
abstract: The general exposure of humans and foxes to polychlorinated biphenyls (PCBs) and DDT in Italy was determined by analysis of adipose tissue samples collected from 1991-1992. sigma PCB concentrations varied between 1.0 and 2.6 micrograms/g (wet wt.). sigma DDT concentrations ranged from 1.6 to 5.0 micrograms/g (wet wt.). About thirty-five PCB congeners were identified in most samples. PCB congeners of IUPAC Nos. 138, 153, and 180 were the most abundant compounds, accounting for an average of 50% of the sigma PCBs in humans and 64% in foxes. Generally, higher chlorinated biphenyls and those with a 2,4,5-chlorine substitution in one ring and at least one substitution in the 4-position of the other ring were preferentially accumulated. Coplanar PCB congeners were detected at considerable concentrations and there is no sign of decline in their concentrations with respect to previously reported data. IUPAC Nos. 118, 156 and 126 were the main contributors to toxicity in humans and foxes. The significant contribution of mono-ortho congeners in humans and non-ortho congeners in foxes suggests that differences in metabolic potential may affect the PCB toxicity pattern.
authors.affiliation: Dipartimento di Biologia Ambientale, Università di Siena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Corsolini
authors.forename: S
authors.initials: S
authors.lastname: Focardi
authors.forename: K
authors.initials: K
authors.lastname: Kannan
authors.forename: S
authors.initials: S
authors.lastname: Tanabe
authors.forename: R
authors.initials: R
authors.lastname: Tatsukawa
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D005589:Foxes / Q000378:metabolism*; D006801:Humans; D007558:Italy; D011078:Polychlorinated Biphenyls / Q000009:adverse effects / Q000032:analysis*; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects / Q000032:analysis*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls