Superoxide radical and toxicity of environmental nickel exposure.
Three nickel compounds were tested for pancreatic, hepatic and osteogenic damage in rats by a single i.m. injection Ni++ (7 mg kg-1). The nickel induced biochemical alterations included significantly increased levels of serum alkaline phosphatase in rats with NiS (75%) and NiO (50%). Amylase and aspartate transaminase were also increased, and lipoperoxide was increased in rats with NiO (5.6-fold) and NiS (3.4-fold). No serum changes were observed with NiCl2. Daily injection of Cu-Zn superoxide dismutase (SOD) conjugated with polyethylene glycol prevented the serum level changes, indicating that superoxide radical is an important intermediate in toxicity of nickel insoluble compounds.
Novelli
E L
EL
Departamento de Química, Universidade Estadual Paulista, UNESP, Botucatu, São Paulo, Brasil.
Rodrigues
N L
NL
Ribas
B O
BO
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D004781:Environmental Exposure; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000633:toxicity; D008099:Liver / Q000187:drug effects; D008297:Male; D009532:Nickel / Q000032:analysis / Q000633:toxicity*; D010179:Pancreas / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000378:metabolism / Q000502:physiology; D013481:Superoxides / Q000633:toxicity*
D006898:Hydroxylamines; D013481:Superoxides; D019811:Hydroxylamine; C022838:nickel chloride; D009532:Nickel; C028007:nickel monoxide; D013482:Superoxide Dismutase; C017558:nickel sulfide