title: Acute renal failure and multiorgan failure.
abstract: Acute renal failure is often seen in the context of multiorgan failure, and thus there is likely to be a common mechanism based on septicaemia or endotoxaemia. The role of gut mucosal dysfunction during shock or in infected ICU patients is a potential common factor. With that in mind the probable role of endotoxin as a causative agent in acute renal failure is addressed.
authors.forename: E N
authors.initials: EN
authors.lastname: Wardle
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D004731:Endotoxins / Q000633:toxicity; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007413:Intestinal Mucosa / Q000503:physiopathology; D009102:Multiple Organ Failure / Q000209:etiology* / Q000503:physiopathology; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology; D012769:Shock / Q000150:complications / Q000503:physiopathology; D014115:Toxemia / Q000150:complications / Q000503:physiopathology
chemical_list: D004731:Endotoxins