title: Testing for segregation distortion in the HLA complex.
abstract: One of the long-standing issues in HLA research is whether there is segregation distortion in the HLA complex in human populations. In this paper we study some simple statistical models aimed at detecting segregation distortion. We present a statistic to test the Mendelian null hypothesis of equal transmission probabilities. To assess the possible contribution of multiple alleles to segregation distortion, we employ a specific log-linear model for transmission probabilities equivalent to the Bradley-Terry model in the literature of paired comparisons. We also provide a simple method for detecting a single allele effect, if present.
authors.affiliation: Department of Integrative Biology, University of California, Berkeley 94720.
authors.forename: K
authors.initials: K
authors.lastname: Jin
authors.forename: T P
authors.initials: TP
authors.lastname: Speed
authors.forename: W
authors.initials: W
authors.lastname: Klitz
authors.forename: G
authors.initials: G
authors.lastname: Thomson
mesh_terms: D000483:Alleles; D001699:Biometry / Q000379:methods; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009679:Nuclear Family; D011336:Probability
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens