Cerebrospinal fluid concentration of neuron-specific enolase in diagnosis of Creutzfeldt-Jakob disease.
Neuron-specific enolase (NSE) is among the biochemical markers in cerebrospinal fluid reported to be useful in the differential diagnosis of Creutzfeldt-Jakob disease from other dementing illnesses. In a group of 58 patients with definite and probable Creutzfeldt-Jakob disease, NSE concentrations (median 94.0, interquartile range 256 ng/mL) were significantly higher (p < 0.001) than in 26 control patients (9.5, 15.5 ng/mL). At a cut-off of 35 ng/mL an optimum sensitivity of 80% with a specificity of 92% for the diagnosis of Creutzfeldt-Jakob disease by NSE in cerebrospinal fluid was obtained.
Zerr
I
I
Neurologische Klinik, Georg-August-Universität Göttingen, Germany.
Bodemer
M
M
Räcker
S
S
Grosche
S
S
Poser
S
S
Kretzschmar
H A
HA
Weber
T
T
D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D004796:Clinical Enzyme Tests; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood / Q000134:cerebrospinal fluid*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
D010751:Phosphopyruvate Hydratase