(+)-(S)-dihydroaeruginoic acid, an inhibitor of Septoria tritici and other phytopathogenic fungi and bacteria, produced by Pseudomonas fluorescens.
Three antibiotics were isolated from a CH2Cl2 extract of the liquid culture of Pseudomonas fluorescens strain PFM2. Two of the antibiotics were identified as 2,4-diacetylphloroglucinol and pyoluterin. The structure elucidation, absolute stereochemistry, synthesis, and biological activities of the new antibiotic (+)-(S)- dihydroaeruginoic acid [1] are reported.
Carmi
R
R
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Israel.
Carmeli
S
S
Levy
E
E
Gough
F J
FJ
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003470:Culture Media; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011551:Pseudomonas fluorescens / Q000378:metabolism*; D013844:Thiazoles / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003470:Culture Media; D013844:Thiazoles; C055755:2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxylic acid