title: Isolation and characterization of a cytotoxic metabolite of Talaromyces bacillosporus.
abstract: A cytotoxic metabolite, talarotoxin, was isolated from a fungus, Talaromyces bacillosporus IFO 8397, cultured on rice. The structure of the toxin was elucidated and found to contain a pyrrolizidinedione connected with a trans delta 1-octalin through a conjugated triene.
authors.affiliation: Laboratory of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Horie
authors.forename: Y
authors.initials: Y
authors.lastname: Ueno
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000378:metabolism*; D002455:Cell Division; D003460:Crystallization; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D009183:Mycotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D014407:Tumor Cells, Cultured
chemical_list: D003603:Cytotoxins; D009183:Mycotoxins; D011763:Pyrrolizidine Alkaloids; C093066:talarotoxin