Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial.
The published studies of topical cyclosporin (CyA) therapy in chronic oral lichen planus (OLP) have shown conflicting results. We report an investigator-blinded study of 13 patients with OLP, who were randomly assigned to treatment with CyA (500 mg as a swish-and-spit medication for 5 min three times daily) or a corticosteroid oral paste (triamcinolone acetonide). The duration of treatment was 6 weeks. Thereafter, patients on corticosteroid therapy were treated with CyA. Only slight, transient clinical improvement was observed in both groups after 6 weeks of treatment, compared with baseline. No significant differences could be demonstrated between the two groups. CyA therapy following corticosteroid treatment did not produce any further clinical improvement. During follow-up of the disease for up to 1 year after treatment, neither the CyA nor the corticosteroid group exhibited long-term improvement in disease activity. Contradictory results from earlier reports are discussed.
Sieg
P
P
Department of Head and Neck Surgery, Medical University of Lübeck, Germany.
Von Domarus
H
H
Von Zitzewitz
V
V
Iven
H
H
Färber
L
L
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy*; D011446:Prospective Studies; D014222:Triamcinolone Acetonide / Q000627:therapeutic use
D016572:Cyclosporine; D014222:Triamcinolone Acetonide