[The effect of the level of lipid peroxidation and the pH value of a liposomal suspension on its antibacterial activity].
Multilamellar phosphatidylcholine liposomes have been shown to possess antibacterial activity with respect to Pseudomonas aeruginosa and Staphylococcus aureus. An increase in the level of lipid peroxidation products in liposomal suspension as the consequence of the earlier oxidation of liposomal lipid leads to a considerable increase in the antibacterial activity of liposomes. The pH of the liposomal suspension has also an essential influence on its activity. If the pH of the suspension has acidic values, its antibacterial activity increases. The bactericidal action of liposomal suspension is more pronounced with respect to S. aureus, than to P. aeruginosa.
Mel'iantseva
L P
LP
Kreĭnes
V M
VM
Bulgakov
V G
VG
D004337:Drug Carriers; D006863:Hydrogen-Ion Concentration; D015227:Lipid Peroxidation / Q000276:immunology*; D008081:Liposomes / Q000276:immunology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013535:Suspensions; D013997:Time Factors
D004337:Drug Carriers; D008081:Liposomes; D013535:Suspensions
Vliianie urovnia perekisnogo okisleniia lipidov i velichiny pH liposomal'noĭ suspenzii na ee antibakterial'nuiu aktivnost'.