Urinary N-acetyl-beta-D-glucosaminidase activity in leukaemic children during high-dose methotrexate therapy.
Urinary N-acetyl-beta-D-glucosaminidase (NAG-ase) activity is a very sensitive parameter of kidney proximal tubular damage. Using urinary NAG-ase activity/urinary creatinine as the NAG index, the serum methotrexate (MTX) level and urinary pH were investigated simultaneously. These parameters were measured in 17 leukaemic children. During MTX treatment, NAG indices were normal in 5 children and only slightly elevated occasionally in 9 patients. Among them, transiently high serum MTX levels (Patient A) or low urinary pH (Patient B) were accompanied by high NAG indices. MTX toxicity has been diagnosed in 3 cases, when permanently high NAG indices were in accordance with other clinical signs.
Oláh
V A
VA
Pediatric Department, University Medical School, Debrecen, Hungary.
Békési
A
A
Tóth
A
A
Kovács
I
I
Balla
G
G
D000118:Acetylglucosaminidase / Q000652:urine*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers / Q000652:urine; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000652:urine; D002648:Child; D003404:Creatinine / Q000652:urine; D004231:Diuresis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007674:Kidney Diseases / Q000139:chemically induced* / Q000201:enzymology; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D002955:Leucovorin / Q000627:therapeutic use; D007938:Leukemia / Q000188:drug therapy* / Q000652:urine; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000652:urine; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D009363:Neoplasm Proteins / Q000652:urine; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000652:urine
D015415:Biomarkers; D009363:Neoplasm Proteins; D003404:Creatinine; D000118:Acetylglucosaminidase; D002955:Leucovorin; D008727:Methotrexate