title: Is neuro-ectodermal differentiation of Ewing's sarcoma of bone associated with an unfavourable prognosis?
abstract: Among Ewing's sarcoma (ES) of bone and related entities are tumours with neuro-ectodermal features that could represent a biologically distinct type. In order to assess the prognostic significance of the various forms of ES, a retrospective joint study involving three cancer centres in Europe and the U.S.A. was initiated. The material from 315 primary ES was reviewed by a panel of five pathologists and classified as typical ES (220 cases), atypical ES (48 cases) or ES with neuro-ectodermal features (47 cases). Prognostic factor analysis on treatment failure-free survival was performed using the Cox model. It included histopathological classification, initial patient characteristics, clinical presentation and treatment type. After multivariate analysis, in addition to treatment type (P < 0.001), metastases (P = 0.003) and proximal tumour location (P = 0.006), two histopathological parameters correlated with poor treatment failure-free survival, the presence of filigree pattern (P = 0.044) and dark cells (P = 0.043). We conclude that ES with neuro-ectodermal features does not appear to have a different outcome to the other subtypes.
authors.affiliation: Département d'Anatomie Pathologique, Institut Gustave Roussy, Villejuif, France.
authors.forename: P
authors.initials: P
authors.lastname: Terrier
authors.forename: M
authors.initials: M
authors.lastname: Henry-Amar
authors.forename: T J
authors.initials: TJ
authors.lastname: Triche
authors.forename: M E
authors.initials: ME
authors.lastname: Horowitz
authors.forename: M J
authors.initials: MJ
authors.lastname: Terrier-Lacombe
authors.forename: J S
authors.initials: JS
authors.lastname: Miser
authors.forename: T J
authors.initials: TJ
authors.lastname: Kinsella
authors.forename: G
authors.initials: G
authors.lastname: Contesso
authors.forename: A
authors.initials: A
authors.lastname: Llombart-Bosch
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001859:Bone Neoplasms / Q000473:pathology* / Q000628:therapy; D002454:Cell Differentiation; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012512:Sarcoma, Ewing / Q000473:pathology* / Q000628:therapy; D016037:Single-Blind Method