[Oncogenic activity of head and neck tumors].
Some types of malignant neoplasms are consequence of genetic changes. The starting of oncogenesis begins when some genetic alterations arises, or the genome acquires some peculiar and pathological traits owing to the action of physical, chemical or viral agents. These alterations set in motion an activatory phenomenon upon the proto-oncogene which is turned into an oncogene. The oncogene is responsible for fixed alterations of the genome inducing to an anomalous cellular growth. In squamous carcinomata of the head and neck has been observed mutations of the p-53 tumour-suppressor gene, alike amplifications of the ras-gene, of the C-myc proto-oncogene and also of the epidermal growth factor gene (EGFG). The viruses induce mutations on the genome. That would be the explanatory reason for the association carcinoma of the rhinopharynx-Epstein-Barr virus.
Basterra
J
J
Hospital General Universitario, Facultad de Medicina, Valencia.
Armengot
M
M
Martorell
M
M
Barona
R
R
Montalt
J
J
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004279:DNA, Viral; D004815:Epidermal Growth Factor / Q000235:genetics; D005784:Gene Amplification; D011905:Genes, ras; D015894:Genome, Human; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D009305:Nasopharynx / Q000473:pathology* / Q000821:virology; D017354:Point Mutation; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D012367:RNA, Viral
D004279:DNA, Viral; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012367:RNA, Viral; D004815:Epidermal Growth Factor
Actividad oncogénica en tumores de cabeza y cuello.