title: [Quantitative analysis of individual renal function using 99mTc-DMSA scintigram--comparison with 131I-OIH renogram].
abstract: 99mTc-2,3-di-mercapto-succinic acid (DMSA) is able to be used for the quantitative analysis of individual renal function by calculating the uptake ratio. The purpose of this study is to assess the clinical feasibility of DMSA uptake ratio as compared with 131I-ortho-iodo-hippuran (OIH) renogram pattern. Two hundred eleven cases (191 patients, 1 to 87 years old) with renal disorders and 4 normal volunteers (27.8 +/- 2.4 years old) were studied. Just prior to the DMSA study in the same day, OIH renogram was carried out. They were divided into 6 types by OIH renogram patterns. In 24 cases of normal renogram pattern and normal blood data who were defined as the normal group and 4 normal volunteers, DMSA uptake ratio showed negative correlation with increasing age (r = 0.61, p < 0.05). Patients of the severe impaired functioning and the non functioning patterns showed significantly decreased DMSA uptake ratios as compared with the normal pattern. There was also a significant difference in DMSA uptake between impaired functioning patterns. Compensative hemi-hypertrophy kidneys showed significantly higher DMSA uptake ratios than those of atrophic kidneys. The possibility of the quantitative analysis of the functional compensation was presumed. In conclusion, quantitative analysis of individual renal function using DMSA uptake ratio is considered to be useful to evaluate the renal functional reserve.
authors.affiliation: Department of Radiology, Fujita Health University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Komai
authors.forename: H
authors.initials: H
authors.lastname: Toyama
authors.forename: A
authors.initials: A
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: S
authors.initials: S
authors.lastname: Koga
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D007465:Iodohippuric Acid; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer