title: Effect of inhaled furosemide on lung clearance of technetium-99m-DTPA.
abstract: The diuretic furosemide has been reported to have a protective effect on allergic asthmatic reactions. This study was performed to investigate the effect of aerosolized furosemide on the lung clearance of 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA).
  
  
  METHODS
  Pulmonary clearance rates of 99mTc-DTPA were measured by a computerized gamma camera with and without the inhalation of aerosol furosemide in 6 nonsmoking normal volunteers (Group 1), 7 smokers without pulmonary disease (Group 2) and 11 patients with asthma (Group 3).
  
  
  RESULTS
  None of the six normal volunteers showed significant effects of inhaled furosemide on the 99mTc-DTPA clearance rates. Three of seven smokers presented an accelerated 99mTc-DTPA clearance by inhaled furosemide and the other four showed no significant change of 99mTc-DTPA clearance by furosemide inhalation. However, in 10 of 11 patients with asthma, there was significant suppression of 99mTc-DTPA clearance by furosemide inhalation.
  
  
  CONCLUSIONS
  Asthmatics possess a furosemide-sensitive mechanism. Pulmonary aerosol scintigraphy with 99mTc-DTPA will be useful in predicting the effect of inhaled furosemide therapy.
authors.affiliation: Department of Nuclear Medicine, Gunma University, School of Medicine, Maebashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Shigeta
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: A
authors.initials: A
authors.lastname: Morikawa
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Tateno
authors.forename: N
authors.initials: N
authors.lastname: Oriuchi
authors.forename: T
authors.initials: T
authors.lastname: Hirano
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005665:Furosemide / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D012907:Smoking / Q000378:metabolism; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics*
chemical_list: D005665:Furosemide; D016284:Technetium Tc 99m Pentetate