Cylindol A, a novel biphenyl ether with 5-lipoxygenase inhibitory activity, and a related compound from Imperata Cylindrica.
Cylindol A [1] and B [2], two novel substances, have been isolated from Imperata cylindrica, and their structures have been elucidated on the basis of their spectral data coupled with chemical evidence and total synthesis. Cylindol A [1] showed 5-lipoxygenase inhibitory activity.
Matsunaga
K
K
Department of Pharmaceutical Molecular Biology, Tohoku University, Sendai, Japan.
Ikeda
M
M
Shibuya
M
M
Ohizumi
Y
Y
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D010226:Parabens / Q000302:isolation & purification* / Q000494:pharmacology; D010647:Phenyl Ethers / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
D004365:Drugs, Chinese Herbal; D016859:Lipoxygenase Inhibitors; D010226:Parabens; D010647:Phenyl Ethers; C091086:cylindrol A; C091087:cylindol B