Bone mineral density in children and adolescents with juvenile diabetes: selective measurement of bone mineral density of trabecular and cortical bone using peripheral quantitative computed tomography.
Bone mineral density (BMD) was studied in 21 children and adolescents with type I diabetes and in age- and sex-matched healthy controls. BMD was selectively measured in trabecular and total bone using peripheral quantitative computed tomography (pQCT). Cortical bone density was calculated. There was a decrease of trabecular bone density (-18.9%, p < 0.01), total bone density (-9.0%, NS) and cortical bone density (-5.1%, NS) in diabetes. Trabecular bone density was inversely correlated with the duration of diabetes and the concentration of glycosylated hemoglobin (HbA1) (r = -0.48, p = 0.027 and r = -0.63, p = 0.002, respectively). Total BMD correlated inversely with HbA1 (r = -0.52, p = 0.017). pQCT allows the selective measurement of metabolically active trabecular bone where changes of mineralization first occur. We conclude that pQCT is a useful method for investigating BMD in diabetes.
Lettgen
B
B
Department of Pediatrics, University of Essen, Germany.
Hauffa
B
B
Möhlmann
C
C
Jeken
C
C
Reiners
C
C
D000293:Adolescent; D000328:Adult; D015519:Bone Density; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed