title: Mutagenic activity of the Ganges water with special reference to the pesticide pollution in the river between Kachla to Kannauj (U.P.), India.
abstract: Water samples from Ganga river were collected from 3 different locations viz. Kachla, Fatehgarh and Kannauj (U.P.). High performance liquid chromatography analysis of samples by liquid-liquid extraction procedure showed the presence of some pesticides like DDT, alpha-BHC, aldrin, dieldrin etc. DDT, alpha-BHC, DDD, aldrin and dieldrin were present at concentration ranges of 3.33-5.33 ppb, 1.73-3.01 ppb, 0.88-2.41 ppb, 1.17-2.81 ppb and 0.49-4.11 ppb, respectively. The organophosphorus pesticides like dimethoate and methyl parathion were also detected at the concentration levels of 0.41-0.56 ppb and 0.16-0.50 ppb, respectively. The organic substances in the test samples were extracted by XAD-resin and liquid-liquid extraction procedures, and the extracts were assayed for mutagenic potential by the Ames Salmonella/microsome test. The test samples exhibited a remarkable degree of mutagenicity with TA98, TA100 and TA97a strains with the probable role of contaminating pesticides in the river water.
authors.affiliation: Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
authors.forename: Z
authors.initials: Z
authors.lastname: Rehana
authors.forename: A
authors.initials: A
authors.lastname: Malik
authors.forename: M
authors.initials: M
authors.lastname: Ahmad
mesh_terms: D001482:Base Composition; D002851:Chromatography, High Pressure Liquid; D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects; D005618:Fresh Water / Q000737:chemistry; D007194:India; D009152:Mutagenicity Tests; D010573:Pesticide Residues / Q000032:analysis / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
chemical_list: D004269:DNA, Bacterial; D010573:Pesticide Residues; D014874:Water Pollutants, Chemical