title: [Tumor markers CEA, CA 15-3, MCA, TPA, ferritin and PTH in the diagnosis and monitoring of primary breast cancer].
abstract: Sera from 254 females were assayed for markers of tumor growth, such as cancer embryonal antigen (CEA), breast cancer-associated antigen (CA 15-3), mucinoid cancer antigen (MCA), ferritin, tissue polypeptide antigen (TPA), parathyroid hormone (PTH) by means of monoclonal antibody kits by using radioimmunoassay and enzyme immunoassay. Forty nine patients were diagnosed as having benign breast neoplasms, 171 patients were admitted to the clinic for primary breast cancer of varying severities, 34 patients without any breast abnormalities and somatic diseases comprised a control group. There was a close correlation between the higher levels of markers and the stage of a tumorous process. Various therapies-induced decreases in the levels of the markers serve as an objective criterion for the efficiency of the latter. Steady increases in the mean concentrations of tumor markers in the intra- and post-therapeutical periods are indicative of an extremely poor prognosis in this group of patients.
authors.forename: V P
authors.initials: VP
authors.lastname: Letiagin
authors.forename: I V
authors.initials: IV
authors.lastname: Vysotskaia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000628:therapy; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D005293:Ferritins / Q000097:blood*; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D015409:Mastectomy, Radical; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D011184:Postoperative Period; D011379:Prognosis; D011879:Radiotherapy Dosage
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D010281:Parathyroid Hormone; C057387:mucinous carcinoma-associated antigen; D005293:Ferritins; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Opukholevye markery REA, CA 15-3. MCA, TPA, ferritin i PTG v diagnostike i monitoringe pervichnogo raka molochnoĭ zhelezy.