title: Platelet monoamine oxidase activity and deficit syndrome schizophrenia.
abstract: Measures of affective flattening that combine self-reported emotional experience with observed affect may identify deficit syndrome patients better than ratings based on observed affect alone. In this study, we examined 23 clinically stable but chronically ill schizophrenic patients, 15 of whom were found to have a deficit syndrome. After exclusion of patients with self-reported depressed mood from the deficit syndrome group, the remaining patients with a deficit syndrome not accompanied by self-reported depressed mood showed a strikingly homogeneous distribution of platelet monoamine oxidase activity. Results suggest that inclusion of self-reported emotional experience in clinical definitions of the deficit syndrome will increase the specificity of diagnosis.
authors.affiliation: Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Samson
authors.forename: R J
authors.initials: RJ
authors.lastname: Gurrera
authors.forename: L
authors.initials: L
authors.lastname: Nisenson
authors.forename: J J
authors.initials: JJ
authors.lastname: Schildkraut
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000201:enzymology* / Q000523:psychology; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D002908:Chronic Disease; D003863:Depression / Q000175:diagnosis / Q000201:enzymology / Q000523:psychology; D004644:Emotions / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010552:Personality Assessment; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000201:enzymology*; D012565:Schizophrenic Psychology
chemical_list: D008995:Monoamine Oxidase