title: Der(16)t(1;16)(q11;q11) in myelodysplastic syndromes: a new non-random abnormality characterized by cytogenic and fluorescence in situ hybridization studies.
abstract: The der(16)t(1;16)(q11;q11) is a frequent recurrent rearrangement in solid tumours such as breast carcinomas and Ewings sarcomas. Recently, this abnormality was described also in multiple myeloma. We identified a der(16)t(1;16)(q11;q11) in three patients with myelodysplastic syndrome, either during preleukaemic phase (n = 2) or at the time of blastic transformation (n = 1). Breakpoints were ascertained by fluorescence in situ hybridization (FISH) using specific centromeric alpha-satellite probes and whole chromosome painting for chromosome 1 and chromosome 16. These observations, combined with isolated cases of the literature, suggest that der(16)t(1;16)(q11; q11) is a nonrandom abnormality associated with myelodysplastic syndromes.
authors.affiliation: Laboratory of Cytogenetics, Faculty of Medicine, Dijon, France.
authors.forename: F
authors.initials: F
authors.lastname: Mugneret
authors.forename: N
authors.initials: N
authors.lastname: Dastugue
authors.forename: B
authors.initials: B
authors.lastname: Favre
authors.forename: I
authors.initials: I
authors.lastname: Sidaner
authors.forename: B
authors.initials: B
authors.lastname: Salles
authors.forename: F
authors.initials: F
authors.lastname: Huguet-Rigal
authors.forename: E
authors.initials: E
authors.lastname: Solary
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D015342:DNA Probes; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D011289:Preleukemia / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D015342:DNA Probes