title: The influence of vascular pressure and different primes on the fluid balance of, and oxygen supply to, the patient during CABG.
abstract: Detrimental changes of blood and erythrocyte rheology, and fluid exchange between the vascular and interstitial spaces, which influence the rate that oxygen is supplied to the patient, occur during cardiac bypass surgery. Venous flow is subject to a pulsatile and uncertain variation, because the vena cava is more than 30 mmHg below atmospheric pressure. This occurs because the patient is about 1 m above the air-blood surface of the bypass reservoir. Before any reliable study of fluid exchange can be undertaken this effect must be controlled. It was then established that optimum oxygen exchange occurs when equilibration of the plasma oncotic pressure and the capillary hydrostatic pressure is achieved without alteration of the interstitial fluid volume. At the lower arterial blood pressures used during bypass, it is necessary to reduce the plasma oncotic pressure by using an appropriate volume of crystalloid prime.
authors.affiliation: Department of Cardiothoracic Surgery, St Mary's Hospital, London, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Sirs
authors.forename: B
authors.initials: B
authors.lastname: Glenville
authors.forename: R L
authors.initials: RL
authors.lastname: Stanbridge
authors.forename: F
authors.initials: F
authors.lastname: Sogliani
authors.forename: G
authors.initials: G
authors.lastname: Stavrides
authors.forename: A W
authors.initials: AW
authors.lastname: Griffiths
authors.forename: J
authors.initials: J
authors.lastname: Jones
authors.forename: K
authors.initials: K
authors.lastname: Macleod
authors.forename: A
authors.initials: A
authors.lastname: Akins
authors.forename: J
authors.initials: J
authors.lastname: Powell
mesh_terms: D001026:Coronary Artery Bypass; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006874:Hydrostatic Pressure; D007552:Isotonic Solutions; D010101:Oxygen Consumption; D000077325:Ringer's Lactate; D013696:Temperature; D014690:Venous Pressure / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate