Cardiac chamber-specific beta-adrenoceptor regulation and sympathetic innervation.
We assessed by radioligand binding techniques the effect of cardiac failure on beta-adrenoceptor density in 5 hearts from patients undergoing repeat transplantation and 5 normal (unused donor) hearts. Right ventricular total and subtype beta-adrenoceptors in the denervated repeat-transplant hearts were down-regulated compared with the normally innervated controls. Within the denervated hearts, beta 1-adrenoceptors were selectively down-regulated in the right ventricle compared with the left ventricle. Tissue noradrenaline content confirmed sympathetic denervation in the transplanted hearts. Thus, regional sympathetic innervation is not necessary for chamber-specific beta-adrenoceptor down-regulation; other mechanisms for this process should be sought.
Chester
M R
MR
National Heart and Lung Institute, London, UK.
Barnett
D B
DB
D000293:Adolescent; D000328:Adult; D003714:Denervation; D015536:Down-Regulation; D006321:Heart / Q000294:innervation; D006333:Heart Failure / Q000378:metabolism*; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012086:Reoperation; D013564:Sympathetic Nervous System / Q000502:physiology*
D011943:Receptors, Adrenergic, beta