Fever in uncomplicated Plasmodium falciparum infection: effects of quinine and paracetamol.
The effects of quinine and paracetamol on fever were studied in 21 adult patients with acute uncomplicated falciparum malaria. Quinine alone (n = 7) had no significant effect on fever, whereas paracetamol given 2 h after quinine (n = 7) or 2 h before quinine (n = 7) reduced temperature by a mean of 2.1 degrees C (standard deviation [SD] 0.95) and 2.1 degrees C (SD 0.79) respectively. A temperature reduction of 1 degree C was associated with a mean decrement of 9.7 beats/min (SD 3.3) in the pulse rate. Quinine does not possess useful antipyretic activity.
Krishna
S
S
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Supanaranond
W
W
Pukrittayakamee
S
S
ter Kuile
F
F
Supputamangkol
Y
Y
Attatamsoonthorn
K
K
Ruprah
M
M
White
N J
NJ
D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D001831:Body Temperature / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D016778:Malaria, Falciparum / Q000150:complications*; D008297:Male; D011803:Quinine / Q000627:therapeutic use*; D013997:Time Factors
D000082:Acetaminophen; D011803:Quinine