title: Sequence of a P-methyltransferase-encoding gene isolated from a bialaphos-producing Streptomyces hygroscopicus.
abstract: The nucleotide sequence of the Streptomyces hygroscopicus gene encoding P-methyltransferase, catalyzing the formation of a carbon-phosphorus bond, involved in bialaphos biosynthesis, has been determined. The amino-acid sequence deduced from the nt sequence, shows homology with those of magnesium-protoporphyrin IX monomethyl ester oxidative cyclase (Mg-ProtoMe cyclase) of Rhodobacter capsulatus and the enzyme catalyzing the methylation of the aldehyde carbon of phosphonoacetaldehyde in fosfomycin biosynthesis.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hidaka
authors.forename: M
authors.initials: M
authors.lastname: Hidaka
authors.forename: T
authors.initials: T
authors.lastname: Kuzuyama
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004269:DNA, Bacterial; D006540:Herbicides / Q000378:metabolism*; D008780:Methyltransferases / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D009943:Organophosphorus Compounds / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism
chemical_list: D004269:DNA, Bacterial; D006540:Herbicides; D009943:Organophosphorus Compounds; C003122:bialaphos; D008780:Methyltransferases; C094206:P-methyltransferase