title: A noninvasive comparative study of myocardial strains in ischemic canine hearts using tagged MRI in 3-D.
abstract: Regional reduction in myocardial function has long been utilized for noninvasive detection and localization of ischemic regions in the left ventricle. In this study, we compared the ability of 13 different myocardial strain indexes to discriminate between ischemic and nonischemic tissue. Using magnetic resonance imaging with tagging and three-dimensional reconstruction, we noninvasively tracked the deformation of 24 myocardial cuboids in each of nine canine hearts with acute ischemia induced by coronary artery ligation. Monastral blue staining was used for postmortem assessment of ischemia. The ability of each index to discriminate between normal and ischemic zones was evaluated using the "t" statistic. The best discrimination was obtained by the endocardial area strain [t = 7.5 +/- 3.0 (SD)], a local measure of systolic shrinkage on the endocardial surface, and by the magnitude of the endocardial principal strain (t = 7.0 +/- 1.9). Transmural wall thickening (t = 6.1 +/- 2.3) was the third best functional index. The same three indexes correlated most closely with perfusion, as assessed by monastral blue staining. These findings imply that these are the preferable functional indexes for mapping of ischemic myocardial regions.
authors.affiliation: Division of Cardiology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA.
authors.forename: H
authors.initials: H
authors.lastname: Azhari
authors.forename: J L
authors.initials: JL
authors.lastname: Weiss
authors.forename: W J
authors.initials: WJ
authors.lastname: Rogers
authors.forename: C O
authors.initials: CO
authors.lastname: Siu
authors.forename: E P
authors.initials: EP
authors.lastname: Shapiro
mesh_terms: D000818:Animals; D004285:Dogs; D006321:Heart / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D013314:Stress, Mechanical