title: [The immunogenetic status of patients with infectious endocarditis].
abstract: On the basis of a deep clinico-immunological examination of 23 patients with septic endocarditis it was established that HLA B35 antigen and haplotype A2-B35 are the most probable markers of the genetic predisposition to the development of infective endocarditis. Immune deficiency is accompanied by a decreased content of T-helpers, decreased activity of natural killers and phagocytic activity of granulocytes. A combination of a genetically determined defect of the immune response with a modification of histocompatibility antigens by infective agents, drugs (narcotics, antigens etc.) and other factors are thought to be of pathogenetic significance in the development of infective endocarditis.
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Shevchenko
authors.forename: V V
authors.initials: VV
authors.lastname: Danil'chenko
authors.forename: E B
authors.initials: EB
authors.lastname: Zhiburt
authors.forename: N B
authors.initials: NB
authors.lastname: Serebrianaia
authors.forename: G G
authors.initials: GG
authors.lastname: Khubulava
authors.forename: I V
authors.initials: IV
authors.lastname: Katkova
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve; D002648:Child; D004198:Disease Susceptibility; D004697:Endocarditis, Bacterial / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006349:Heart Valve Diseases / Q000235:genetics / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D014261:Tricuspid Valve
chemical_list: D006680:HLA Antigens
vernacular_title: Immunogeneticheskiĭ status bol'nykh infektsionnym éndokarditom.