Pulmonary damage due to paraquat poisoning through skin absorption.
A case of recovery from acute respiratory insufficiency due to paraquat is described. A 57-year-old farmer developed breathlessness, high fever and interstitial infiltrates in the upper and middle lung fields few days after percutaneous paraquat poisoning with rapid evolution to pulmonary fibrosis. Anti-inflammatory drugs and antioxidants, were administered to the patient, though with a delay, with some improvement; the patient survived despite residual lung fibrosis. Paraquat lung, as confirmed by this paper, is not invariably fatal.
Papiris
S A
SA
Department of Internal Medicine, University of Ioannina, Greece.
Maniati
M A
MA
Kyriakidis
V
V
Constantopoulos
S H
SH
D000208:Acute Disease; D000382:Agricultural Workers' Diseases / Q000139:chemically induced*; D001205:Ascorbic Acid / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010269:Paraquat / Q000493:pharmacokinetics* / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000188:drug therapy; D012869:Skin Absorption; D014810:Vitamin E / Q000627:therapeutic use
D014810:Vitamin E; D010269:Paraquat; D001205:Ascorbic Acid; D008775:Methylprednisolone