Differences in blood glutathione levels of patients with advanced or localized carcinoma.
OBJECTIVE
The increased level of blood glutathione (GSH) is an important biochemical feature in animal epithelial tumor. The aim of this study was to investigate the blood GSH concentrations in well characterized cancer patients and healthy volunteers.


METHODS
Two different groups of carcinoma cases were used. The first group consisted of 15 blood samples drawn from disseminated gastric adenocarcinoma patients, and the second group comprised 15 samples obtained from localized or locally advanced skin carcinoma cases without lymph node metastasis. GSH and hemoglobin concentrations were measured by using the method of Beutler et al.


RESULTS
The mean blood GSH in patients who had advanced malignant disease was 129.13 +/- 7.49 mg/dl and in patients who had localized cancer was 96.24 +/- 3.90 mg/dl. These results indicate that the blood GSH level is 31% higher in localized carcinoma cases and 78% higher in metastatic disease than those of controls. Blood GSH concentrations were expressed on the basis of blood volume and also on hemoglobin content. Similar results were calculated with either mode of expression.


CONCLUSIONS
By comparing the two groups of patients, we found that higher blood GSH concentration was correlated with metastatic growth.
Engin
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Department of Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey.
D000230:Adenocarcinoma / Q000097:blood; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000097:blood* / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood; D005260:Female; D005978:Glutathione / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000097:blood; D013274:Stomach Neoplasms / Q000097:blood
D006454:Hemoglobins; D005978:Glutathione