Effects of nimodipine, felodipine, and verapamil on isolated human arteries.
OBJECTIVE
To evaluate whether there might be some difference in the action modes of nimodipine (Nim) and felodipine (Fel).


METHODS
Compare the inhibitory effects of Nim and Fel with that of verapamil (Ver) as a representative of phenylalklamine on norepinephrine (NE)- and CaCl2-evoked contractions of human arteries.


RESULTS
In Ca(2+)-free and high K+ depolarized solution, inhibitory effects of Nim, Fel, and Ver were more potent on CaCl2-induced contractions on isolated human arteries than those on NE-induced contractions. In CaCl2-induced contraction, the pD2 values for Nim, Fel, and Ver were 7.5, 7.42, 6.35 on uterine arteries; 7.38, 7.65, 7.20 on mesenteric arteries and 7.87, 9.10, 7.32 on renal arteries, respectively. Ver inhibited 2 components of NE-evoked contraction, while Nim and Fel only inhibited extracellular Ca(2+)-dependent contractions.


CONCLUSIONS
The result indicates that Fel has a selective action on human renal arteries.
Yao
M H
MH
Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical University, China.
Dai
Z X
ZX
Xu
D Z
DZ
Yang
Z C
ZC
D000328:Adult; D002122:Calcium Chloride / Q000037:antagonists & inhibitors; D015736:Felodipine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009553:Nimodipine / Q000494:pharmacology*; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D012077:Renal Artery / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D009553:Nimodipine; D014700:Verapamil; D002122:Calcium Chloride; D015736:Felodipine; D009638:Norepinephrine