title: A reduced dose approach to hepatitis B vaccination for low-risk newborns and preschool children.
abstract: The effectiveness of a 2.5 micrograms dose of the hepatitis B vaccine (B-Hepavac II) was compared with that of 5 micrograms in 587 low-risk neonates and 777 preschool children of age 3-8 years. The vaccines were administered at months 0, 1 and 3, with postvaccination serology tested at months 4 and 12. The seroconversion rates of the 2.5 microgram recipients (newborn: 93.5%; preschool children: 97.4%) are comparable with the 5 micrograms group (newborn: 95.7%; preschool children: 98.7%). The seroconversion rates of the newborns are, however, significantly lower in the 2.5 micrograms group if positive response is taken as a titre > 10 IU l-1, instead of > 0 IU l-1. The older children, on the other hand, achieved a higher seroconversion rate and geometric mean titre (GMT) when compared with the newborns. irrespective of the dose received.
authors.affiliation: Department of Health, Hong Kong Government.
authors.forename: S S
authors.initials: SS
authors.lastname: Lee
authors.forename: Y C
authors.initials: YC
authors.lastname: Lo
authors.forename: B W
authors.initials: BW
authors.lastname: Young
authors.forename: K H
authors.initials: KH
authors.lastname: Wong
authors.forename: W L
authors.initials: WL
authors.lastname: Lim
mesh_terms: D002675:Child, Preschool; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012306:Risk; D014611:Vaccination
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines