title: Modulatory influence of the oral contraceptive pill, Ovral, on 3-methylcholanthrene-induced carcinogenesis in the uterus of mouse.
abstract: The present study examines the modulatory influence of the combined oral contraceptive pill, Ovral (0.05 mg ethynylestradiol plus 0.25 mg levonorgestrel per pill) on methylcholanthrene (MCA)-induced carcinogenesis in the uterus of Swiss albino mouse. Placement of cotton thread impregnated with beeswax containing approximately 600 micrograms of MCA, yielded endometrial squamous cell carcinomas in 53.33% animals in 90 days. Concomitant treatments with doses D1 (1/200th of a pill) and D2 (1/200th of a pill) of Ovral yielded endometrial squamous cell carcinomas in 6.23 and 0% of animals in 90 days (p < 0.05; p < 0.005) respectively. Ovral did not seem to increase the incidence of uterine hyperplasia.
authors.affiliation: Cancer Biology Laboratory, Jawaharlal Nehru University, New Delhi, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Chhabra
authors.forename: S
authors.initials: S
authors.lastname: Kaur
authors.forename: A R
authors.initials: AR
authors.lastname: Rao
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D008748:Methylcholanthrene; D051379:Mice; D009644:Norgestrel / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000139:chemically induced*
chemical_list: D003278:Contraceptives, Oral, Hormonal; D009644:Norgestrel; D004997:Ethinyl Estradiol; D008748:Methylcholanthrene; D019304:Ethinyl Estradiol-Norgestrel Combination