[The comparative characteristics of the spectrum of the pharmacological action of azaleptin and GCh-46].
Experiments on mice and rats were made to make a comparative evaluation of the psychotropic properties of asaleptin (leponex) and GCh-46. There were significant differences between the agents. Asaleptin, as a typical neuroleptic, had no anticonvulsant activity. But preserving some properties of asaleptin, GCh-46 produced pronounced anticonvulsant effects comparable with those shown by traditional antiepileptic agents.
Tregubov
A L
AL
Kolla
V E
VE
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D002375:Catalepsy / Q000139:chemically induced; D003024:Clozapine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D014150:Antipsychotic Agents; C094038:seleptin; D003024:Clozapine
Sravnitel'naia kharakteristika spektra farmakologicheskogo deĭstviia azaleptina i GCh-46.