Do polyunsaturated fatty acids protect against oxidant-induced lung damage?
Little disagreement exists concerning the importance of early provision of lipid nutrition to very low birth weight (VLBW) infants in terms of growth and development. However, considerable controversy surrounds the relationship of lipid and protection against oxidant-induced lung damage in experimental situations and in the vulnerable premature infant. This article reviews the results of experimental and clinical studies on the protective effects of lipids against oxidant injury and chronic lung disease.
Sosenko
I R
IR
Department of Pediatrics, University of Miami School of Medicine, FL 33101, USA.
D000818:Animals; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008171:Lung Diseases / Q000209:etiology / Q000517:prevention & control*; D016877:Oxidants / Q000009:adverse effects*
D005217:Fat Emulsions, Intravenous; D005231:Fatty Acids, Unsaturated; D016877:Oxidants