Persistence of multilineage host haemopoiesis following allogeneic bone marrow transplantation.
The survival of host cells following high-dose cytotoxic therapy and allogeneic marrow transplantation has been established previously, but the identity of these cells has not been elucidated in detail. Four patients who received sex-mismatched marrow have been studied for up to 12 months post-transplant using a simultaneous immunophenotyping/fluorescence in situ hybridization technique. The results demonstrate residual host T cells (CD3+), B cells (CD22+) and myeloid cells (CD11c+ and CD13+), and additionally cells of progenitor cell phenotype (CD34+). The long-term persistence of host haemopoiesis may have major relevance to the post-transplant complications of marrow rejection, graft-versus-host disease, and malignant relapse.
Price
C M
CM
Leukaemia Research Fund Centre, Institute of Cancer Research, London.
Colman
S M
SM
Kanfer
E J
EJ
D001402:B-Lymphocytes; D016026:Bone Marrow Transplantation; D002470:Cell Survival / Q000235:genetics; D005260:Female; D006086:Graft vs Host Disease / Q000235:genetics / Q000473:pathology; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D013601:T-Lymphocytes; D018183:Transplantation Chimera; D014184:Transplantation, Homologous