[Preventive anti-D after massive fetomaternal hemorrhage].
In the 36th week of gestation intrauterine death of both twins occurred in a 31-year old primigravida. The examination of the C- and the D-antigen of the mother's blood (result of previous testing: AB Rhesus negative) immediately before delivery showed a mixed field agglutination which pointed to a fetomaternal macrotransfusion. Fetal haemoglobin in the mother's circulation was 7.8% of her total haemoglobin, so that a fetomaternal haemorrhage of about 440 ml whole blood had to be suspected. For Rhesus-prophylaxis 17 standard doses of anti-D-immunoglobulin were administered intramuscularly distributed over 4 days. No adverse effects were seen; fetal haemoglobin dropped to 2.0% 5 days and to 0.1% 15 days after the beginning of the treatment. A control examination after 9 months showed no signs of a Rhesus-(D)-sensitisation of the patient.
Strobel
E
E
Institut für Medizinische Mikrobiologie, Immunologie und Krankenhaushygiene, Städtisches Krankenhaus München-Schwabing.
Hofmeister
G
G
Wüllenweber
J
J
D005260:Female; D005313:Fetal Death / Q000209:etiology; D005331:Fetomaternal Transfusion / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D007518:Isoantibodies / Q000008:administration & dosage*; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000276:immunology; D012203:Rh Isoimmunization / Q000517:prevention & control*; D018029:Rho(D) Immune Globulin
D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin
Anti-D-Prophylaxe nach massiver fetomaternaler Hämorrhagie.