title: Beta-lactamase inhibitor combinations.
abstract: The beta-lactamase inhibitor combinations present a novel approach to the problem of beta-lactamase-induced resistance to antibiotics. These agents are derived from the generally safe beta-lactam class of antibiotics. They are all principally excreted through the kidneys and require dosage adjustment in the face of significant renal insufficiency. They show significantly increased activity against methicillin-sensitive S. aureus, H. influenzae, B. catarrhalis, and B. fragilis. The activity against Enterococcus, Pseudomonas, and most gram-negative bacilli, however, remains limited to that of the respective antibiotic component. Although shown to be clinically useful in a variety of clinical situations, they appear to be most useful for skin and soft tissue infections and lower respiratory tract infections as well as intra-abdominal and gynecologic infections caused by susceptible pathogens.
authors.affiliation: Saint Michael's Medical Center, Newark, New Jersey, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Sensakovic
authors.forename: L G
authors.initials: LG
authors.lastname: Smith
mesh_terms: D000900:Anti-Bacterial Agents / Q000191:economics / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams