Effects of water deprivation for 48 hours on the pharmacokinetics and pharmacodynamics of furosemide in rats.
The effects of water deprivation for 48 h on the pharmacokinetics and pharmacodynamics of furosemide were examined after intravenous, 8 mg/kg body weight, and oral administration, 16 mg/kg body weight, of furosemide to control and water deprived rats. After i.v. administration, the total body and nonrenal clearances decreased significantly in water-deprived rats. The urine output, urinary excretion of sodium, potassium and chloride based on grams of kidney weight, and the diuretic, natriuretic and chloruretic efficiencies decreased significantly in water-deprived rats after both intravenous and oral administration of furosemide, suggesting that the dose of furosemide for water-deprived patients may require modification.
Kang
M J
MJ
College of Pharmacy, Sookmyung Women's University, Yongsan-Gu, Seoul, South Korea.
Yoon
W H
WH
Kim
O N
ON
Lee
M G
MG
D000284:Administration, Oral; D000818:Animals; D002712:Chlorides / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D004231:Diuresis / Q000187:drug effects*; D005665:Furosemide / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D007262:Infusions, Intravenous; D008297:Male; D011188:Potassium / Q000652:urine; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000652:urine; D014868:Water Deprivation / Q000502:physiology*
D002712:Chlorides; D005665:Furosemide; D012964:Sodium; D011188:Potassium