title: A description of a new DR allele, DRB1*1113.
abstract: We have discovered a previously unpublished HLA-DRB1 allele, observed in a patient (SB), his mother, and one sibling. The undefined allele gave sporadic positive reactions with sera in the DR52-associated group. SSOPH analysis utilizing both generic and group specific primers and probes also gave ambiguous results. SB typed clearly as a DRB1*0301 (paternal allele) but the DNA from SB also bound probes specific for DRB1*14 and DRB1*11. Sequencing revealed that the undefined allele was similar to a DRB1*14 allele with a segment of sequence found in DRB1*11 alleles. The patient was MLC reactive with donors who express DRB1*0301, *1401 and *0301, *11 and was nonreactive solely to DRB1*0301 (Dw3) homozygous typing cells.
authors.affiliation: Tissue Typing Lab, VAMC, Iowa City, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Rosenberg
authors.forename: T F
authors.initials: TF
authors.lastname: Wollenzien
authors.forename: M M
authors.initials: MM
authors.lastname: Johnson
authors.forename: L
authors.initials: L
authors.lastname: Eberly
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
authors.forename: N L
authors.initials: NL
authors.lastname: Reinsmoen
authors.forename: N
authors.initials: N
authors.lastname: Steiner
authors.forename: N E
authors.initials: NE
authors.lastname: Goeken
mesh_terms: D000483:Alleles; D001483:Base Sequence; D005260:Female; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553502:HLA-DRB1*03:01 antigen; D015345:Oligonucleotide Probes