title: Dexamethasone recruits atrial natriuretic peptide secretory cells in the rat left atrium and apex of the ventricle.
abstract: The response of the atrial natriuretic peptide (ANP) secreting cells from both rat atria and the apex of the ventricles to dexamethasone (DEX) was analyzed by the plaque assay. In right atrial cardiocytes, 25% of the cells secreted ANP basally; DEX treatment did not alter this percentage. However, in the left atrial secretory population, a discordance between the basal (15%) and DEX stimulated (25%) percent plaque formation was found. ANP secreting cells from the ventricular apex responded similarly to DEX exposure (26%), with 8% of the cells basally releasing the hormone. These data suggest that in both the left atria and apex of the rat ventricles, exposure to DEX recruits ANP secretory cells from a non-secreting population. Consequently, the release of ANP from these tissues would increase after glucocorticoid stimulation.
authors.affiliation: Department of Biological Sciences, East Tennessee State University, Johnson City 37601-0703, USA.
authors.forename: H A
authors.initials: HA
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Haste
authors.forename: T
authors.initials: T
authors.lastname: Carpenter
authors.forename: S
authors.initials: S
authors.lastname: Maulden
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006325:Heart Atria / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006352:Heart Ventricles / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D009206:Myocardium / Q000166:cytology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D010948:Viral Plaque Assay
chemical_list: D003907:Dexamethasone; D009320:Atrial Natriuretic Factor