The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event.
We have recently identified a common ALL patient which harboured a chromosomal fusion between the TEL gene on chromosome 12 and the ABL gene on chromosome 9. We designed an RT-PCR assay to screen 186 adult ALL and 30 childhood ALL patients for this novel translocation. We were unable to identify any additional cases with a TEL/ABL fusion product.
Janssen
J W
JW
Department of Paediatrics II, University of Ulm, Germany.
Ridge
S A
SA
Papadopoulos
P
P
Cotter
F
F
Ludwig
W D
WD
Fonatsch
C
C
Rieder
H
H
Ostertag
W
W
Bartram
C R
CR
Wiedemann
L M
LM
D000328:Adult; D001483:Base Sequence; D002648:Child; D002881:Chromosomes, Human, Pair 12; D002899:Chromosomes, Human, Pair 9; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D016313:Genes, abl; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics*; D000097764:ETS Translocation Variant 6 Protein
D004268:DNA-Binding Proteins; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D014157:Transcription Factors; D000097764:ETS Translocation Variant 6 Protein