title: Quadruple cancer including Bowen's disease after arsenic injections 40 years earlier: report of a case.
abstract: This report describes the successful treatment of quadruple cancer including Bowen's disease in a 71-year-old man who had been given injections of salvarsan, an arsenic compound, for syphilis more than 40 years earlier. Resection of a skin lesion on his chest subsequently confirmed a diagnosis of Bowen's disease, 3 years after which he was operated on for concurrent gastric cancer and sigmoid colon cancer. A fourth cancer was discovered on his left vocal cord 2 weeks after this operation; it was resected 2 years later. A discussion of multiple malignant neoplasms and the possible relationship between arsenic and cancer is presented following this case report.
authors.affiliation: Department of Surgery, Kinki Central Hospital of the Mutual Aid Association of Public School Teachers, Itami, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Murata
authors.forename: T
authors.initials: T
authors.lastname: Iwazawa
authors.forename: T
authors.initials: T
authors.lastname: Takayama
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: K
authors.initials: K
authors.lastname: Okagawa
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000601:surgery; D000236:Adenoma / Q000175:diagnosis / Q000601:surgery; D000368:Aged; D001153:Arsphenamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001913:Bowen's Disease / Q000175:diagnosis / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery; D003082:Colectomy; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis / Q000601:surgery; D007642:Keratosis / Q000139:chemically induced; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D009378:Neoplasms, Multiple Primary; D012008:Recurrence; D012811:Sigmoid Neoplasms / Q000175:diagnosis / Q000601:surgery; D012812:Sigmoidoscopy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000601:surgery; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000601:surgery; D013587:Syphilis / Q000188:drug therapy; D013997:Time Factors; D014827:Vocal Cords / Q000601:surgery
chemical_list: D001153:Arsphenamine