title: Prevention of bovine ketosis with glucogenic substance and its effect on fertility in Finnish dairy cows.
abstract: To avoid a harmful peak of negative energy balance, 200 ml of a 50% propylene glycol and 1% nicotinic amide solution were given twice a day to dairy cattle for ten days starting at day 14 post partum (p.p). Acetone content in milk was used as an indicator of energy balance and fertility was used as an indicator of the efficiency of the treatment. In addition, other factors affecting fertility were evaluated. During the prevention period, the acetone level in the prevention group (N = 31) decreased from 0.40 +/- 0.1 O mmol/l to 0.23 +/- 0.06 mmol/l (p = 0.09), but in the control group (N = 35) it increased from 0.23 +/- 0.04 mmol/l to 0.43 +/- 0.29 mmol/l acetone from the beginning to the end of the trial (p > 0.10). At day 50 p.p., however, the acetone levels in the two groups were the same. The treatment did not prevent clinical ketosis. Clinical ketosis tended to be associated with impaired fertility; in contrast, cows in the prevention group treated for ketosis had high fertility. A high daily milk yield at the first monthly recording test as well as high annual milk, fat and protein yields were correlated with the interval from calving to conception, r = 0.33, r = 0.50, r = 0.37 and r = 0.47, respectively. A low percentage of annual milk protein and at test 1 was significantly correlated with a long interval from calving to conception, r=-0.31 and r=-0.45, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anatomy, University of Kuopio, Finland.
authors.forename: P V
authors.initials: PV
authors.lastname: Miettinen
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D019342:Acetic Acid; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D005260:Female; D005298:Fertility / Q000187:drug effects; D007662:Ketosis / Q000517:prevention & control / Q000662:veterinary*; D007774:Lactation / Q000187:drug effects; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000627:therapeutic use*; D013402:Sugar Alcohols / Q000627:therapeutic use*
chemical_list: D000085:Acetates; D011409:Propylene Glycols; D013402:Sugar Alcohols; D019946:Propylene Glycol; D019342:Acetic Acid