Ischemic optic neuropathy and high-level anticardiolipin antibodies in primary Sjögren's syndrome.
A 39-year-old woman with recurrent severe anterior ischemic optic neuropathy in the setting of Sjögren's syndrome was found to have high-titer IgM anticardiolipin antibodies (aCL) that were enhanced by the phospholipid-binding glycoprotein beta 2GP1. The recognition of IgM aCL-associated vasculopathy as a possible etiologic factor in the optic neuropathy in Sjögren's syndrome may be relevant in deciding appropriate therapy.
Rosler
D H
DH
LSU Medical Center, Department of Medicine, Section of Rheumatology in New Orleans 70112-2822, USA.
Conway
M D
MD
Anaya
J M
JM
Molina
J F
JF
Carr
R F
RF
Gharavi
A E
AE
Wilson
W A
WA
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D009901:Optic Nerve Diseases / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology*
D017153:Antibodies, Anticardiolipin