title: Does early growth delay occur in diabetic pregnancy?
abstract: OBJECTIVE
  To identify the date of ovulation in pregnant women with Type 1 diabetes in order to assess the validity of the concept of early growth delay.
  
  
  METHODS
  Identification of ovulation by measurement of urinary luteinising hormone and assessment of fetal growth using ultrasound scan.
  
  
  METHODS
  Diabetic pre-pregnancy and antenatal clinic in a teaching hospital.
  
  
  METHODS
  Twenty women with Type 1 diabetes who had attended a pre-pregnancy clinic.
  
  
  METHODS
  Urinary LH, by laboratory and kit methods, during conception cycles. Human chorionic gonadotrophin measured in early pregnancy. Early ultrasound scans by a single observer blind to menstrual and ovulation dates.
  
  
  RESULTS
  Gestation calculated from ovulation date and gestation estimated from menstrual dates, compared with gestation at age indicated by early ultrasound scan.
  
  
  RESULTS
  When the date of ovulation was identified in 20 women with Type 1 diabetes there was no evidence of growth delay in any pregnancy. When gestation was estimated from menstrual dates there was apparent early growth delay in six pregnancies.
  
  
  CONCLUSIONS
  This study, together with others discussed, indicates that early growth delay is probably an artefact of incorrectly estimated ovulation date.
authors.affiliation: Department of Diabetes, Royal Infirmary Edinburgh.
authors.forename: J M
authors.initials: JM
authors.lastname: Steel
authors.forename: P S
authors.initials: PS
authors.lastname: Wu
authors.forename: F D
authors.initials: FD
authors.lastname: Johnstone
authors.forename: B B
authors.initials: BB
authors.lastname: Muir
authors.forename: V M
authors.initials: VM
authors.lastname: Sweeting
authors.forename: S G
authors.initials: SG
authors.lastname: Hillier
mesh_terms: D003922:Diabetes Mellitus, Type 1; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine; D010061:Ovulation Detection; D016742:Preconception Care; D011247:Pregnancy; D011254:Pregnancy in Diabetics
chemical_list: D007986:Luteinizing Hormone