[In vivo neurochemical effects of electroconvulsive shock on the forced swimming rat].
The effects of electroconvulsive shock (ECS) on monoamine metabolism in the forced swimming rat were studied using on-line microdialysis. In the present experiment, we measured forced swimming-induced immobility time and interstitial concentrations of dopamine (DA), its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the anterior hypothalamus. Mean immobility time was short in the ECS-treated group compared with shamECS group but the difference was not statistically significant. DA and 5-HT tended to increase following a single ECS. Interstitial concentration of 5-HIAA increased significantly. Forced swimming test caused an increase in both DA and 5-HT turnover in the hypothalamus. In contrast, pretreatment with ECS tends to suppress these forced swimming-induced increases in DA and 5-HT turnover. These data suggest that ECS may regulate excess activation in central dopaminergic and serotonergic system following forced swimming stress.
Sasaki
N
N
Department of Neuropsychiatry, School of Medicine, Kyorin University, Tokyo, Japan.
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D004554:Electric Countershock; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
D015306:Biogenic Monoamines