title: t(8;21) myelodysplasia, an early presentation of M2 AML.
abstract: The reciprocal translocation of genetic material between chromosomes 8 and 21, t(8;21), is usually restricted to cases of acute myeloid leukaemia (AML). Cases of AML with t(8;21) exhibit characteristic dysplastic features in myeloid and erythroid lineages with reduction in megakaryocytes. We report details of three patients presenting with myelodysplastic features; two had a typical t(8;21), and the third had a variant t(8;21) translocation. We discuss the significance of t(8;21) in the aetiology of myelodysplastic syndrome (MDS) and implications for the management of such patients.
authors.affiliation: Royal South Hants Hospital, Southampton.
authors.forename: A S
authors.initials: AS
authors.lastname: Taj
authors.forename: F M
authors.initials: FM
authors.lastname: Ross
authors.forename: M
authors.initials: M
authors.lastname: Vickers
authors.forename: D N
authors.initials: DN
authors.lastname: Choudhury
authors.forename: J F
authors.initials: JF
authors.lastname: Harvey
authors.forename: J C
authors.initials: JC
authors.lastname: Barber
authors.forename: C
authors.initials: C
authors.lastname: Barton
authors.forename: A G
authors.initials: AG
authors.lastname: Smith
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014178:Translocation, Genetic