Viridans streptococcal bacteraemia in patients with neutropenia.
Viridans streptococcal bacteraemia is frequent in neutropenic patients. 25 neutropenic patients with viridans streptococcal bacteraemia were compared with 64 control patients. Exposure to repeated chemotherapy or cytarabine were independent risk-factors for streptococcal bacteraemia. The use of carboxyureidopenicillins and a stay in laminar-airflow rooms were protective. In a further cohort study of 49 patients, oral streptococci with the same ribotype as blood isolates were recovered from all 7 bacteraemic patients. The oral cavity is a portal of entry for viridans streptococci bacteraemia in neutropenic patients, especially after oral mucosal damage induced by repeated chemotherapy.
Richard
P
P
Laboratoire de Bactériologie A, Hôtel-Dieu, Nantes, France.
Amador Del Valle
G
G
Moreau
P
P
Milpied
N
N
Felice
M P
MP
Daeschler
T
T
Harousseau
J L
JL
Richet
H
H
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D016470:Bacteremia / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D016022:Case-Control Studies; D003561:Cytarabine / Q000009:adverse effects; D004780:Environment, Controlled; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology; D009503:Neutropenia / Q000150:complications*; D011446:Prospective Studies; D012307:Risk Factors; D012463:Saliva / Q000382:microbiology; D013290:Streptococcal Infections / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D013291:Streptococcus / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003561:Cytarabine