Does the HIV-1 manipulate immune network via gp120 immunoglobulin-like domain involving V3 loop?
According to the multiple criteria used, the consensus sequences of HIV-1 gp120 and immunoglobulin heavy chain variable segment, which is more than 40 amino acids long, show structural similarities. We assume that this gp120 sequence might encode idiotopes. If this is the case then the particular idiotope-bearing gp120, either soluble or expressed in multiple form on the surface of the infected cell, can influence the immune response in idiotype(Id)-anti-Id fashion. This might be the mechanism by which HIV induces immunological abnormalities and it should be taken into consideration in vaccine production as suggested by the authors previously.
Metlas
R
R
Laboratory for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, Beograd, Yugoslavia.
Veljković
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V
D000595:Amino Acid Sequence; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000276:immunology
D015699:HIV Envelope Protein gp120; D007130:Immunoglobulin Idiotypes; D007135:Immunoglobulin Variable Region