[The effect of D-penicillamine on the metabolism of the basic substance of the connective tissue and the indices of the liver parenchyma in experimental cirrhosis in rats].
While examining the effects of D-penicillamine [correction of D-penicillin] on the formation of hepatic toxic damage in mature male Wistar rats from the stage of developing cirrhosis to that of the developed one, the author revealed a high antifibrotic activity of the drug which significantly normalized the metabolism of the major agent of the hepatic connective tissue; there was a slight improvement of parenchymal metabolism when the agent was taken for 2 months. There were apparently healthy animals in the experimental group following 4-month course of the therapy. Control rats developed hepatic damage, as evidenced by electron microscopic studies.
Skobeleva
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TV
D000118:Acetylglucosaminidase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D003238:Connective Tissue / Q000187:drug effects* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006025:Glycosaminoglycans / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D010396:Penicillamine / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D006025:Glycosaminoglycans; D000118:Acetylglucosaminidase; D010396:Penicillamine
Vliianie D-penitsillamina na obmen osnovnogo veshchestva soedinitel'noĭ tkani i nekotorye pokazateli parenkhimy pecheni pri éksperimental'nom tsirroze u krys.