Isolation and characterization of a cytotoxic metabolite of Talaromyces bacillosporus.
A cytotoxic metabolite, talarotoxin, was isolated from a fungus, Talaromyces bacillosporus IFO 8397, cultured on rice. The structure of the toxin was elucidated and found to contain a pyrrolizidinedione connected with a trans delta 1-octalin through a conjugated triene.
Ishii
K
K
Laboratory of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Itoh
T
T
Kobayashi
K
K
Horie
Y
Y
Ueno
Y
Y
D000818:Animals; D001203:Ascomycota / Q000378:metabolism*; D002455:Cell Division; D003460:Crystallization; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D009183:Mycotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D003603:Cytotoxins; D009183:Mycotoxins; D011763:Pyrrolizidine Alkaloids; C093066:talarotoxin