title: Simulating efficiently the evolution of DNA sequences.
abstract: Two menu-driven FORTRAN programs are described that simulate the evolution of DNA sequences in accordance with a user-specified model. This general stochastic model allows for an arbitrary stationary nucleotide composition and any transition-transversion bias during the process of base substitution. In addition, the user may define any hypothetical model tree according to which a family of sequences evolves. The programs suggest the computationally most inexpensive approach to generate nucleotide substitutions. Either reproducible or non-repeatable simulations, depending on the method of initializing the pseudo-random number generator, can be performed. The corresponding options are offered by the interface menu.
authors.affiliation: Technical University Munich, Garching, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schöniger
authors.forename: A
authors.initials: A
authors.lastname: von Haeseler
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D005075:Biological Evolution; D003198:Computer Simulation; D004247:DNA / Q000235:genetics*; D005069:Evaluation Studies as Topic; D008957:Models, Genetic; D010802:Phylogeny; D012984:Software; D013269:Stochastic Processes
chemical_list: D004247:DNA