title: In utero surfactant administration to preterm human fetuses using endoscopy.
abstract: Our purpose was to assess the feasibility of the endoscopic delivery of surfactant directly to the fetus during active preterm labor. A gas-sterilized intraoperative fiberscope was introduced through the cervical canal into the amniotic cavity after spontaneous rupture of membranes during preterm labor in 3 patients. The flexible fiberscope was inserted under constant endoscopic visual control to avoid possible trauma to the fetus and the mother. Surfactant was injected into the mouths of 3 preterms fetuses through a catheter placed through the biopsy channel of the fiberscope. Fetal heart rate tracings as well as neonatal and maternal outcome are reported for each case. In utero surfactant placement was successful in each case. The fetal heart rate remained normal throughout the procedure. No maternal or neonatal complications/infections were detected. Our preliminary experience indicates that in utero endoscopic delivery of surfactant to a preterm human fetus is feasible. The usefulness of intrapartum endoscopy in the prophylactic administration of surfactant directly to the fetus, prior to the first breath, has to be assessed in a prospective controlled study.
authors.affiliation: North Shore University Hospital, Cornell University Medical College, Manhasset, N.Y., USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Petrikovsky
authors.forename: A
authors.initials: A
authors.lastname: Lysikiewicz
authors.forename: L B
authors.initials: LB
authors.lastname: Markin
authors.forename: Z
authors.initials: Z
authors.lastname: Slomko
mesh_terms: D000328:Adult; D004333:Drug Administration Routes; D004724:Endoscopy / Q000379:methods*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control; D013997:Time Factors
chemical_list: D011663:Pulmonary Surfactants