title: Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.
abstract: A novel anti-hepatitis B virus (anti-HBV) agent, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU), was synthesized and found to be a potent anti-HBV and anti-Epstein-Barr virus agent. Its in vitro potency was evaluated in 2.2.15 and H1 cells for anti-HBV and anti-Epstein-Barr virus activities, respectively. In vitro cytotoxicity in MT2, CEM, 2.2.15, and H1 cells was also assessed, and the results indicated high antiviral selectivities of L-FMAU in these cells.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens 30602, USA.
authors.forename: C K
authors.initials: CK
authors.lastname: Chu
authors.forename: T
authors.initials: T
authors.lastname: Ma
authors.forename: K
authors.initials: K
authors.lastname: Shanmuganathan
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Xiang
authors.forename: S B
authors.initials: SB
authors.lastname: Pai
authors.forename: G Q
authors.initials: GQ
authors.lastname: Yao
authors.forename: J P
authors.initials: JP
authors.lastname: Sommadossi
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004272:DNA, Mitochondrial / Q000032:analysis; D006515:Hepatitis B virus / Q000187:drug effects*; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D004272:DNA, Mitochondrial; D001086:Arabinofuranosyluracil; C034935:clevudine