title: Adjunctive therapy in epilepsy: a cost-effectiveness comparison of alternative treatment options.
abstract: A pharmaco-economic study of the administration of adjunctive therapy in patients with chronic epilepsy is described. A decision-analytic model has been used, which represents the consequences of treatment over a 1-year time period, when one of three drugs is used first. The cost-effectiveness ratio for clobazam, lamotrigine and vigabatrin have been calculated. The expected cost per patient of treatment over the 1-year period was up to 50% higher with vigabatrin and lamotrigine compared with clobazam, with a cost-effectiveness ratio around 40% higher.
authors.affiliation: Arthur D. Little Ltd, Berkley Square, London, UK.
authors.forename: B A
authors.initials: BA
authors.lastname: O'Neill
authors.forename: M R
authors.initials: MR
authors.lastname: Trimble
authors.forename: D S
authors.initials: DS
authors.lastname: Bloom
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D000588:Amines; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000009:adverse effects / Q000191:economics* / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D000078306:Clobazam; D003362:Cost-Benefit Analysis; D003509:Cyclohexanecarboxylic Acids; D003661:Decision Support Techniques; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy* / Q000191:economics*; D005071:Evoked Potentials / Q000187:drug effects; D000077206:Gabapentin; D006801:Humans; D000077213:Lamotrigine; D008134:Long-Term Care / Q000191:economics; D014227:Triazines / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives / Q000191:economics / Q000627:therapeutic use
chemical_list: D000085:Acetates; D000588:Amines; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D003509:Cyclohexanecarboxylic Acids; D014227:Triazines; D001569:Benzodiazepines; D000078306:Clobazam; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D020888:Vigabatrin; D000077213:Lamotrigine