title: Fluorophotometric study of lens autofluorescence and the blood-retinal barrier in 56 diabetic patients.
abstract: We examined lens autofluorescence and the permeability of the blood-retinal barrier in 56 diabetic patients (34 insulin-dependent and 22 non-insulin-dependent), using the Fluorotron Master (R), a commercially available fluorophotometer. Significant relationships were found between age and lens autofluorescence (p < 0.01), between duration of diabetes and lens autofluorescence in insulin-dependent diabetics (p < 0.01), and between duration of diabetes and blood-retinal barrier permeability in all diabetics (p < 0.05). The relationships between lens autofluorescence and duration of diabetes in non-insulin dependent patients (p > 0.05), and between lens autofluorescence or the penetration ratio and HBA Ic during the five preceding years (p > 0.05) were not significant. Fluorophotometry provides an objective and reproducible method for in vivo investigation of the ocular complications of diabetes and of the factors influencing them.
authors.affiliation: Department of Ophthalmology, Gui de Chauliac Hospital, Montpellier, France.
authors.forename: B
authors.initials: B
authors.lastname: Bordat
authors.forename: C
authors.initials: C
authors.lastname: Arnaud
authors.forename: I R
authors.initials: IR
authors.lastname: Guirguis
authors.forename: A
authors.initials: A
authors.lastname: Laudeho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001813:Blood-Retinal Barrier; D002199:Capillary Permeability / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D005453:Fluorescence; D015590:Fluorophotometry; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D005452:Fluoresceins; D019793:Fluorescein