[Angiotensin II induces c-fos and c-myc proto-oncogene expression in the left ventricle].
In the present study, the effects of angiotension II on the expression of protooncogene c-fos and c-myc in the left ventricle were investigated on Langedorff heart preparations. It was observed that angiotensin induced both c-fos and c-myc expression in a dose-dependent manner and the c-fos expression showed an earlier appearance than c-myc. All these induced expressions were blocked by a Angiotensin II receptor antagonist saralasin. The Angiotensin II induced expression of c-fos was also blocked by TTX, but the c-myc gene expression was unaffected.
Chen
W H
WH
Laboratory of Receptor, Sun Yat-Sen University of Medical Sciences, Guangzhuo.
Tan
D D
DD
Pan
J Y
JY
Hu
B R
BR
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos; D016259:Genes, myc; D006352:Heart Ventricles; D066298:In Vitro Techniques; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012504:Saralasin / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
D012333:RNA, Messenger; D000804:Angiotensin II; D013779:Tetrodotoxin; D012504:Saralasin