title: [Tubulointerstitial nephritis-uveitis syndrome (TINU syndrome)].
abstract: For 10 weeks a 25-year-old man had been suffering from tiredness, fatigue, nausea and a 16 kg weight loss. Erythrocyte sedimentation rate (83/133 mm), serum C-reactive protein (5.5 mg/dl) and creatinine (5.05 mg/dl) were all elevated. He also had proteinuria (1120 mg daily), sterile leukocytosis and a creatinine clearance of 10 ml/min. Renal biopsy showed interstitial nephritis and bone marrow biopsy revealed non-caseous epithelioid-cell granulomas. 14 days after admission he developed acute iritis in the right eye. Other causes having been excluded, the diagnosis of tubulo-intestinal nephritis with uveitis (TINU syndrome) was made. The clinical symptoms and laboratory findings improved within a few days of the start of glucocorticoid treatment (initially, 100 mg prednisone daily, reduced to 5 mg within 30 days). The patient was discharged after 8 days in good general condition.
authors.affiliation: I. Medizinische Klinik und Poliklinik, Universität Mainz.
authors.forename: F
authors.initials: F
authors.lastname: Gohlke
authors.forename: E
authors.initials: E
authors.lastname: Wandel
authors.forename: M
authors.initials: M
authors.lastname: Christmann
authors.forename: K H
authors.initials: KH
authors.lastname: Meyer zum Büschenfelde
authors.forename: E
authors.initials: E
authors.lastname: Hermann
mesh_terms: D000208:Acute Disease; D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007500:Iritis / Q000188:drug therapy; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D013577:Syndrome; D013997:Time Factors; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D011241:Prednisone
vernacular_title: Tubulointerstitielle-Nephritis-Uveitis-Syndrom (TINU-Syndrom).