[The effect of Sandimmun on the rate of oxygen consumption by lymphocytes].
Experiments on male Wistar rat thymocytes have demonstrated that cyclosporin A, an active substance of the immunodepressive agent sandimmune given in concentrations of 1 to 10 micrograms/ml, has no effects on cellular oxygen consumption rates measured by the polarographic technique by using a Clarke electrode. At the same time cyclosporin A suppressed thymocyte respiration stimulated by the oxidative phosphorylation release 2,4-DNP (40 micrograms/M) by 18 and 56% when given by concentrations of 2 and 10 micrograms/ml, respectively. The relationship between the adverse effects clinically observed and the findings was also examined.
Ratnikova
L A
LA
Astashkin
E I
EI
D000818:Animals; D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism*
D016572:Cyclosporine
Vliianie sandimmuna na skorost' potrebleniia kisloroda limfotsitami.