Vanadium: a modifier of drug-metabolizing enzyme patterns and its critical role in cellular proliferation in transplantable murine lymphoma.
Vanadium, as ammonium monovanadate, has been found to stimulate tumour cell proliferation in mice bearing a transplantable ascitic lymphoma. Markers including microsomal cytochrome P-450, UDP-glucuronyltransferase and cytosolic glutathione-S-transferase showed substantial alterations in a dose-responsive manner with vanadium administration when compared to the controls. Stimulation of tumour progression is also reflected by increased tumour cell count and decreased survival of the host.
Chakraborty
A
A
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Ghosh
R
R
Roy
K
K
Ghosh
S
S
Chowdhury
P
P
Chatterjee
M
M
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005982:Glutathione Transferase / Q000378:metabolism*; D008223:Lymphoma / Q000201:enzymology; D051379:Mice; D013997:Time Factors; D014639:Vanadium / Q000008:administration & dosage / Q000494:pharmacology*
D014639:Vanadium; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase