[Chemotherapy against lymphatic metastases of gynecologic cancer via pelvic retroperitoneal cannulation: a preliminary report].
Lymphatic metastasis is one of the most important problems in the treatment of gynecologic malignancy. We conducted a preliminary investigation on the feasibility and practicality of chemotherapy against lymphatic metastases of gynecologic cancer via pelvic retroperitoneal cannulation. 5-FU mixed with Isovist-300 was injected into the pelvic retroperitoneal space. X-ray films revealed that the external iliac, hypogastric, obturator, deep inguinal and most of the common iliac lymph nodes were submerged in the 5-FU solution. 5-FU concentrations in the lymph nodes were measured by high pressure liquid chromatography, which showed that 5-FU concentration of the study group was 2 to 10 times that of the control group. Pathologic findings revealed that most of the metastatic cancer cells in the study group showed obvious degeneration and necrosis while no changes were observed in the control group. No major complications or adverse effects were observed. Our results suggest that this method may be used to treat the lymphatic metastases of gynecologic cancer.
Cao
Z
Z
Second Affiliated Hospital, West China University of Medical Sciences, Chengdu.
You
Z
Z
Zhou
S
S
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000818:Animals; D002404:Catheterization; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011817:Rabbits; D012187:Retroperitoneal Space
D005472:Fluorouracil