Cell shape changes and detachment in cell culture: models of renal injury.
Loss of tubular cell adhesion may be important in the pathophysiology of injury to renal tubular cell epithelium. In-vitro model systems have been utilized to examine altered cell adhesion in response to hypoxic/anoxic and oxidant-induced cell injury. Alterations in cell cytoskeleton and cell surface adhesion molecules, including L-CAM and integrins, have been demonstrated in these systems, and are probably important in the pathogenesis of altered structure and function in response to injury in renal tubular epithelium.
Racusen
L C
LC
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
D000818:Animals; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion; D015687:Cell Hypoxia; D048429:Cell Size; D002478:Cells, Cultured; D004847:Epithelial Cells; D004848:Epithelium / Q000293:injuries; D006801:Humans; D016023:Integrins / Q000502:physiology; D007684:Kidney Tubules / Q000166:cytology / Q000293:injuries* / Q000502:physiology; D008954:Models, Biological
D015820:Cadherins; D016023:Integrins