title: Sex differences in patterns of hemispheric cerebral metabolism: a multiple regression/discriminant analysis of positron emission tomographic data.
abstract: Sex differences in brain hemispheric structure and function have been reported, and sex-related differences in hemispheric interregional correlations were reported in a prior analysis of resting PET glucose metabolic (rCMRglc) data. To explore further the effect of sex on patterns of hemispheric brain functional interactions, we applied a multiple regression/discriminant analysis to resting rCMRglc PET data from young normal men and women to test two hypotheses: (1) women have stronger between-hemisphere functional interactions; (2) men have stronger within-hemisphere functional interactions. Two separate discriminant functions based on these hypotheses distinguished men and women: the first reflected rCMRglc interdependencies between hemispheres and correctly classified all women and 94% of the men; the second reflected rCMRglc interdependencies within the left hemisphere and correctly classified 82% of the women and 88% of the men. Because the discriminant functions successfully distinguished men and women, these results provide support for both hypotheses.
authors.affiliation: Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: N P
authors.initials: NP
authors.lastname: Azari
authors.forename: K D
authors.initials: KD
authors.lastname: Pettigrew
authors.forename: P
authors.initials: P
authors.lastname: Pietrini
authors.forename: D G
authors.initials: DG
authors.lastname: Murphy
authors.forename: B
authors.initials: B
authors.lastname: Horwitz
authors.forename: M B
authors.initials: MB
authors.lastname: Schapiro
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001931:Brain Mapping; D016002:Discriminant Analysis; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012727:Sex Characteristics; D014055:Tomography, Emission-Computed