G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.
G-protein-coupled receptor signaling and receptor tyrosine kinase (RTK) signaling are two mechanisms of transmembrane communication used by numerous extracellular agents and stimuli. The beta gamma-subunit complex of G proteins mediates many of the functions associated with G-protein-coupled receptor signaling and may even provide a means to link G proteins to RTK-initiated cascades. This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.
Inglese
J
J
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
Koch
W J
WJ
Touhara
K
K
Lefkowitz
R J
RJ
D000818:Animals; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D010750:Phosphoproteins; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism
D001798:Blood Proteins; D010750:Phosphoproteins; C039077:platelet protein P47; D020794:Receptor Protein-Tyrosine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019204:GTP-Binding Proteins; D018631:ras Proteins