Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents.
The Gfi1 gene encodes a zinc finger protein which binds DNA and is involved in transcriptional regulation. Gfi1 was assigned to the central portion of mouse Chr 5 by interspecific backcross mapping and to human chromosome band 1p22 and rat chromosome band 14p22 by fluorescence in situ hybridization (FISH). Comparative mapping data presented here describes a new syntenic region between man and rodents.
Bell
D W
DW
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Taguchi
T
T
Jenkins
N A
NA
Gilbert
D J
DJ
Copeland
N G
NG
Gilks
C B
CB
Zweidler-McKay
P
P
Grimes
H L
HL
Tsichlis
P N
PN
Testa
J R
JR
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006224:Cricetinae; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D009115:Muridae / Q000235:genetics; D051381:Rats / Q000235:genetics*; D014157:Transcription Factors; D016335:Zinc Fingers / Q000235:genetics*
D004268:DNA-Binding Proteins; C498275:GFI1 protein, human; C079873:Gfi1 protein, mouse; C498276:Gfi1 protein, rat; D014157:Transcription Factors