title: Reflections on the natural history of lipomyelomeningocele.
abstract: A retrospective analysis of patients with lipomyelomeningocele cared for at two referral centers was completed to derive relationships between neurological function and patient age. Thirty-seven percent of 177 patients had intact neurological function on initial examination. Neurological deficits were progressive and linked with a logarithmic relationship to increasing patient age. Each child with intact examination retained normal bladder function following lipomyelomeningocele repair and release of cord tethering; complications of surgery were limited. Our analysis suggests that surgery on patients with intact function offers greater long-term protection of critical function than is offered by conservative management and expectant care. We recommend repair of lipomyelomeningocele at the time of diagnosis regardless of patient age or neurological function.
authors.affiliation: Department of Neurosurgery, Temple University School of Medicine, Philadelphia, Pa., USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Kanev
authors.forename: K S
authors.initials: KS
authors.lastname: Bierbrauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008067:Lipoma / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D008161:Lumbosacral Region / Q000473:pathology / Q000601:surgery*; D008591:Meningomyelocele / Q000150:complications* / Q000601:surgery*; D011183:Postoperative Complications; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D016136:Spina Bifida Occulta / Q000150:complications* / Q000601:surgery*