title: Platelet function studies in Indian kala-azar.
abstract: Platelet function studies were conducted on 25 parasitologically positive cases of Indian kala-azar and 25 age and sex matched healthy controls. Ninety-two per cent of patients had thrombocytopenia of variable degree; in 44% of patients, platelets were less than 60,000 mm-3. The platelet adhesive index was less than 30% in 70% of patients with kala-azar (normal 31-60%). Platelet aggregation time with ADP and adrenaline was abnormally prolonged compared to the controls. Platelet factor III availability was poor in 40% of cases. There was a fair degree of correlation between platelet adhesiveness and platelet factor III availability in these patients: 50% of patients with poor platelet adhesiveness showed reduced platelet factor III availability.
authors.affiliation: Department of Medicine, Banaras Hindu University, Varanasi, India.
authors.forename: B
authors.initials: B
authors.lastname: Dube
authors.forename: A
authors.initials: A
authors.lastname: Arora
authors.forename: V P
authors.initials: VP
authors.lastname: Singh
authors.forename: K
authors.initials: K
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Sundar
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D007194:India; D007898:Leishmaniasis, Visceral / Q000097:blood*; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010976:Platelet Count; D010977:Platelet Factor 3 / Q000378:metabolism; D010979:Platelet Function Tests
chemical_list: D010977:Platelet Factor 3