[Tactics in choosing a vascular collector and drug administration method in intra-arterial infusion therapy of organs of vision].
Anatomical variants of the direction and diameter of the supraorbital artery revealed by the authors and the clinical variants of the intensity and direction of periorbital bloodstream shown by doppler studies helped optimize the selection of a facial artery for inserting an infusion system for drug delivery to the vascular system of the eye. The advantages of intraarterial infusion of drugs in the system of ocular blood supply using an automated thermo-infusion dispenser vs. the traditional methods are demonstrated: no side effects on the intraocular and regional hemodynamics, purposeful delivery of drugs to the site of ocular blood supply with a simple and convenient device. This method for the choice of a collector for intraarterial infusions and the method of drug infusion were clinically tried in 2 groups of patients: with retrobulbar intoxication neuritis and partial atrophy of the optic nerve (a total of 21 patients, 23 operations for implantation of infusion system; control group consisted of 11 patients). 120-Hour infusion therapy with, alternately, trental and actovegin resulted in improvement of the vision acuity from 0.03-0.06 to 0.3-0.8 in virtually all group 1 patients. Moreover, central scotomas disappeared and the conductivity of the axial bundle of the optic nerve recovered from 28-32 to 38-40 Hz. In group 2 defects in the visual field disappeared and its peripheral borders widened. In controls no improvement of the visual function was observed.
Krasnov
M M
MM
Baiandin
D L
DL
Vorob'eva
O K
OK
Klimchenko
Iu G
IuG
D000328:Adult; D000368:Aged; D000697:Central Nervous System Stimulants / Q000008:administration & dosage; D005123:Eye / Q000098:blood supply*; D005128:Eye Diseases / Q000188:drug therapy*; D005260:Female; D006418:Heme / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D009896:Optic Atrophy / Q000188:drug therapy; D009902:Optic Neuritis / Q000188:drug therapy; D010431:Pentoxifylline / Q000008:administration & dosage; D014792:Visual Acuity; D014794:Visual Fields
D000697:Central Nervous System Stimulants; D006418:Heme; C015646:Actovegin; D010431:Pentoxifylline
Taktika vybora sosudistogo kollektora i sposoba vvedeniia lekarstvennykh veshchestv v metodike vnutriarterial'noĭ infuzionnoĭ terapii organov zreniia.