Intestinal T-cell lymphoma with massive tissue and blood eosinophilia mediated by IL-5.
A case of enteropathy associated T-cell lymphoma (EATCL) in a 62-year-old female with a previous history of coeliac disease, complicated during the clinical course by massive blood and tissue eosinophilia is described. The patient's serum contained a factor capable of stimulating the in vitro growth of eosinophilic colonies (CFU-Eo), that was absent in the serum of normal donors. We suggest that such factor was Interleukin-5 (IL-5), as indicated by the presence in the monoclonal tumor T cells of IL-5 encoding mRNA, usually absent in the normal enterocytes of the jejunum.
Gallamini
A
A
Divisione di Medicina, University of Torino, Italy.
Carbone
A
A
Lista
P
P
Cavallero
G
G
Reato
G
G
Fruttero
A
A
Novero
D
D
Asnaghi
G
G
di Celle
P F
PF
Foa
R
R
D002455:Cell Division / Q000502:physiology; D004273:DNA, Neoplasm / Q000032:analysis; D004802:Eosinophilia / Q000097:blood* / Q000209:etiology*; D005260:Female; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D015848:Interleukin-5 / Q000235:genetics / Q000494:pharmacology*; D007414:Intestinal Neoplasms / Q000097:blood* / Q000150:complications* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000097:blood* / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics
D004273:DNA, Neoplasm; D015848:Interleukin-5; D012333:RNA, Messenger