[Inhibition of glutamate uptake in rat brain synaptosome by pyrethroids].
In vitro studies showed deltamethrin (1 x 10(-7)-1 x 10(-4) mol/L) could inhibit 3H-DL-glutamate uptake in rat cerebral cortex and hippocampus synaptosome by 7.2%-21.5% and 10.4%-25.1%, respectively, with a dose-response pattern. But only in high-dose permethrin (1 x 10(-4) mol/L) can significantly reduce 3H-DL-glutamate uptake in rat hippocampus synaptosome. In addition, deltamethrin also can reduce 3H-DL-glutamate uptake in cerebellum and striatum of rats by 16.5% and 31.8%, respectively. It is suggested that both deltamethrin and permethrin, especially the former, can disturb the function of brain tissue in high-affinity-glutamate uptake with their alpha-cyano-group. So pyrethroids could play an important role in cerebral stimulation in mammals.
Zhao
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X
Department of Environmental Toxicology, Tongji Medical University, Wuhan.
Dai
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S
Chen
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G
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism* / Q000493:pharmacokinetics; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009570:Nitriles; D026023:Permethrin; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013574:Synaptosomes / Q000378:metabolism*
D005971:Glutamates; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D026023:Permethrin