title: Bioactive anthraquinone glycosides from Picramnia antidesma spp. fessonia.
abstract: A bioactivity guided fractionation, using KB cells and brine shrimp assays, of the methanolic extract from the leaves of Picramnia antidesma yielded two known anthraquinones, aloe-emodin and aloe-emodin anthrone, and three new aloe-emodin C-glycosides, named picramnioside A, picramnioside B and picramnioside C. Structures were established by spectroscopic methods (UV, IR, mass spectrometry, 1H and 13C and 2D NMR including COSY 45, HMQC, HMBC and ROESY). CD was used to establish the absolute configuration of the picramniosides.
authors.affiliation: Department of Pharamacognosy, School of Pharmacy, London, U.K.
authors.forename: P N
authors.initials: PN
authors.lastname: Solis
authors.forename: A G
authors.initials: AG
authors.lastname: Ravelo
authors.forename: A G
authors.initials: AG
authors.lastname: Gonzalez
authors.forename: M P
authors.initials: MP
authors.lastname: Gupta
authors.forename: J D
authors.initials: JD
authors.lastname: Phillipson
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis; D014197:Trees / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D006027:Glycosides