The effect of oral treatment with 6-O-butanoyl castanospermine (MDL 28,574) in the murine zosteriform model of HSV-1 infection.
Oral treatment of mice, cutaneously infected with herpes simplex virus type 1 (HSV-1) (strain SC16), with the alpha-glucosidase 1 inhibitor 6-O-butanoyl castanospermine (MDL 28,574) produced a significant delay in lesion development and reduced the amount of virus recovered from the brain. Virus load in the brains of mice, whose treatment started 2 days prior to infection, was reduced approximately 100-fold when compared to untreated controls. Treatment initiated at the time of infection, while less effective than pre-treatment, nevertheless reduced virus recovery from the brain by 10-fold. Consistent with its antiviral activity, orally administered MDL 28,574 was rapidly incorporated by brain tissue and mice fed with compound over extended periods maintained relatively high levels of drug at this site.
Bridges
C G
CG
MRC Collaborative Centre, London, UK.
Ahmed
S P
SP
Kang
M S
MS
Nash
R J
RJ
Porter
E A
EA
Tyms
A S
AS
D000212:Acyclovir / Q000627:therapeutic use; D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology / Q000821:virology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy* / Q000473:pathology; D007212:Indolizines / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000302:isolation & purification*; D013997:Time Factors; D054836:Indolizidines
D000212:Acyclovir; D000998:Antiviral Agents; D007212:Indolizines; C070715:celgosivir; D054836:Indolizidines