A model for the membrane topology of the NS3 protein as predicted from the sequence of segment 10 of epizootic haemorrhagic disease virus serotype 1.
Segment 10, encoding nonstructural proteins 3 (NS3) and 3a (NS3a) of epizootic haemorrhagic disease virus serotype 1 (EHDV-1) was sequenced. Computer motif recognition programs were used for interpretation of the sequence data to predict a structure for NS3. Integral membrane protein theories were then applied to produce a general topological model for the EHDV-1 NS3 protein. Homology was observed between EHDV-1 NS3 integral membrane motifs and those similarly observed in the cognate proteins of other orbiviruses.
Jensen
M J
MJ
USDA, Agricultural Research Service, Arthropod-borne Animal Diseases Research Laboratory, Laramie, Wyoming, USA.
Wilson
W C
WC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D006224:Cricetinae; D018164:Hemorrhagic Disease Virus, Epizootic / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D012703:Serotyping; D014709:Vero Cells; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000235:genetics
C089247:S10 protein, epizootic hemorrhagic disease virus 2; D017361:Viral Nonstructural Proteins