title: The effect of ranitidine on symptom relief and quality of life of patients with gastro-oesophageal reflux disease.
abstract: A 4-week study involving 354 patients with the symptoms of gastro-oesophageal reflux disease was conducted to assess the effect of ranitidine (as effervescent tablets) on their relief and quality of life. All patients received 150 mg bd for 2 weeks, with those responding to treatment continuing on the same dosage for a further 2-week period and 'non-responders' having the dosage increased to 150 mg qds for a further 2 weeks. Quality of life and symptom assessments were carried out at 0, 2 and 4 weeks. Two weeks' treatment with ranitidine 150 mg bd was effective at controlling the GORD symptoms in 78% of patients. A 4-week treatment with either 150 mg bd or qds controlled the symptoms in 85% of patients. All patients had significant improvements in all dimensions of their quality of life over the study period.
authors.affiliation: Glaxo Laboratories Ltd, Uxbridge, Middlesex.
authors.forename: K L
authors.initials: KL
authors.lastname: Chal
authors.forename: J H
authors.initials: JH
authors.lastname: Stacey
authors.forename: G E
authors.initials: GE
authors.lastname: Sacks
mesh_terms: D000328:Adult; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D011788:Quality of Life; D011899:Ranitidine / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011899:Ranitidine