title: Acute hepatitis A with coexistent hepatitis C virus infection presenting as a virus-associated hemophagocytic syndrome: a case report.
abstract: A 23-yr-old male with acute hepatitis A and coexistent hepatitis C became critically ill 3 wk after the onset of fever and jaundice with progressive anemia, thrombocytopenia, and hepatosplenomegaly. Bone marrow biopsy revealed hemophagocytosis. Despite aggressive supportive treatment with parenteral steroids, the patient died of disseminated intravascular coagulopathy with gastrointestinal bleeding. Necropsy of the liver showed histiocyte aggregation in the portal area with hemophagocytosis.
authors.affiliation: Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
authors.forename: C S
authors.initials: CS
authors.lastname: Wu
authors.forename: K Y
authors.initials: KY
authors.lastname: Chang
authors.forename: P
authors.initials: P
authors.lastname: Dunn
authors.forename: T H
authors.initials: TH
authors.lastname: Lo
mesh_terms: D000208:Acute Disease; D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D006506:Hepatitis A / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male