title: Image registration of SPECT and CT images using an external fiduciary band and three-dimensional surface fitting in metastatic thyroid cancer.
abstract: Image registration of 131I SPECT with CT scans was performed in a patient with metastatic thyroid carcinoma using an external fiduciary band and a three-dimensional surface-fitting algorithim. Areas of metastatic disease taking up 131I were accurately localized to the liver, lungs and vertebral bodies; providing information that could not be obtained by planar or SPECT images alone. Based on these findings, further invasive diagnostic procedures were not performed, therefore considerably altering management in this patient. This approach to image registration has immediate clinical utility in the registration and interpretation of SPECT studies with corresponding CT or MRI scans.
authors.affiliation: Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: A M
authors.initials: AM
authors.lastname: Scott
authors.forename: H
authors.initials: H
authors.lastname: Macapinlac
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Daghighian
authors.forename: N
authors.initials: N
authors.lastname: Montemayor
authors.forename: H
authors.initials: H
authors.lastname: Kalaigian
authors.forename: G
authors.initials: G
authors.lastname: Sgouros
authors.forename: M C
authors.initials: MC
authors.lastname: Graham
authors.forename: K
authors.initials: K
authors.lastname: Kolbert
authors.forename: S D
authors.initials: SD
authors.lastname: Yeh
mesh_terms: D000465:Algorithms; D018265:Carcinoma, Papillary, Follicular / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D013125:Spinal Neoplasms / Q000556:secondary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed