title: [Timing of radical operation on Hirschsprung's disease in newborns].
abstract: From June 1987 to June 1993, 42 neonates with Hirschsprung's disease (NHD) were treated with modified Duhamel's procedure. The follow-up from 2 months to 5 years (mean 30 mons) showed satisfactory results in all survivors. Comparing with 21 infants with Hirschsprung's disease treated (IHD) with modified Swenson's method showed that: (1) The follow-up results of NHD were better than IHD; (2) The extent and degree of hypertrophy and dilatation of proximal and transitional segment were less serious in NHD and the length of resection was shorter than that of IHD (NHD: 14.5-24.1 cm, IHD: 33-40.5 cm); (3) The degree of pathological changes such as mucosal inflammation, ulcer formation, and degeneration of ganglion cells was related to the age, duration and the length of agangliosis. Hirschsprung's disease has a chronic progressive course. Early operation can decrease the secondary structural and functional damage to the intestine.
authors.affiliation: Wuhan Children's Hospital.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Jiang
authors.forename: J G
authors.initials: JG
authors.lastname: Hu
authors.forename: J S
authors.initials: JS
authors.lastname: Lu
mesh_terms: D002675:Child, Preschool; D003082:Colectomy / Q000379:methods; D003106:Colon / Q000473:pathology; D003125:Colostomy; D005260:Female; D005500:Follow-Up Studies; D006627:Hirschsprung Disease / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013997:Time Factors