Amisulpride poisoning: a report on two cases.
The first two observations of human poisoning involving the recently developed neuroleptic amisulpride are described. In both cases drug determination was performed using reversed-phase HPLC coupled with diode array detection. Case 1 was a nonfatal overdosage in which the ingestion of 3.0 g amisulpride induced an attack of seizures, then light coma with agitation, hyperthermia, mydriasis, minimal extrapyramidal features, tachycardia and slight prolongation of the QT interval; the blood concentration of amisulpride was 9.63 micrograms ml-1. Case 2 was a fatality attributed to amisulpride in which the measured blood concentration was 41.70 micrograms ml-1. Our results are discussed in the light of data previously reported on the toxicity of substituted benzamides.
Tracqui
A
A
Institut de Médecine Légale, Faculté de Médecine de Strasbourg, France.
Mutter-Schmidt
C
C
Kintz
P
P
Berton
C
C
Mangin
P
P
D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000032:analysis / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000032:analysis / Q000506:poisoning
D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride