[Production technology and in vitro study of rectal suppositories containing chloroquine phosphate].
Chloroquine-phosphate was suspended in various lipophilic and hydrophilic suppository bases in an amount of 250 mg/2.0 g. The authors studied the solidity and the disintegration time of the suppositories as well as the in vitro drug liberation with a membrane diffusion method. The effect of the storage time and the storage circumstances on the stability of the suppositories was observed. Tropics-resistance studies were also carried out at a temperature of 45 degrees C and at a relative humidity content of 75%, thus these suppositories may be used for the treatment of malaria. The Witepsol H 15 base was found to be the best in all respect for use in countries with a continental climate. Finally a function relationship was found between the concentration of the pharmacon and the diffusion time with linear regression analysis.
Regdon Géza
J R
JR
Szent-Györgyi Albert Orvostudományi Egyetem, Gyógyszertechnológiai Intézet, Szeged.
Schirm
I
I
Pittmann
A
A
Regdon
G
G
D000962:Antimalarials / Q000737:chemistry; D002738:Chloroquine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D002980:Climate; D004058:Diffusion; D006801:Humans; D008954:Models, Biological; D012007:Rectum; D012044:Regression Analysis; D013488:Suppositories
D000962:Antimalarials; D013488:Suppositories; C023676:chloroquine diphosphate; D002738:Chloroquine
Klorokinium-foszfát tartalmú végbélkúpok gyártástechnológiája és in vitro vizsgálata.