[The induction of an immune response to influenza virus antigens by anti-idiotypic antibodies].
The present investigation indicate that homologous polyclonal anti-idiotypic antibodies induce both humoral and cell-mediated immune response. Experiments on the exhaustion of immune sera with vaccine have revealed that anti-idiotypic antibodies induce not only specific antibodies to influenza virus antigens, but also antibodies to other epitopes of the globulin molecule of the anti-idiotype. Anti-idiotypic antibodies, when reintroduced into animals, induce the production of anti-influenza antibodies of the anamnestic type, but do not induce the formation of antihemagglutinins. The injection of influenza vaccine to animals, previously immunized with anti-idiotypic antibodies, induces the production of antihemagglutinins; an increase in the level of immune complexes and antibodies to anti-idiotype, i.e. anti-idiotypic antibodies, induces the development of immunological memory with respect to influenza virus antigens, including antihemagglutinins.
Kositskaia
L S
LS
Sofronov
B N
BN
Bichurina
M A
MA
Briantseva
E A
EA
Rozaeva
N R
NR
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology* / Q000302:isolation & purification; D000914:Antibodies, Viral / Q000097:blood; D000936:Antigen-Antibody Complex / Q000097:blood; D000937:Antigen-Antibody Reactions / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D007114:Immunization / Q000379:methods; D007156:Immunologic Memory / Q000276:immunology; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology; D011817:Rabbits; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D007106:Immune Sera; D007252:Influenza Vaccines
Induktsiia immunnogo otveta k antigenam virusa grippa antiidiotipicheskimi antitelami.