D1 receptors modulate striatal dopamine release induced by the stimulation of both D1 and D2 receptors: in vivo voltammetric data revisited.
Here we re-examine previous data that demonstrated lasting effects of the selective D1 receptor agonist SKF 38393, the selective D2 receptor agonist LY 171555, and of mixed SKF 39383 + LY 171555 upon striatal DA release. We demonstrate that the administration of mixed SKF 38393 + LY 171555 and of SKF 38393 administered alone induced similar time-course effects upon striatal DA release that showed significant parallel developments. We discuss these data in the light of the current literature and we suggest that D1 receptors could play a modulating role on the striatal DA activity and the release of DA in the caudate-putamen.
Fechtali
T
T
Laboratoire de Physiologie, Faculté des Sciences Molay Ismail, Meknes, Morócco.
Issoual
D
D
Abraini
J H
JH
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D004558:Electric Stimulation; D004594:Electrophysiology; D004873:Ergolines / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D019257:Quinpirole; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*
D018491:Dopamine Agonists; D065127:Dopamine D2 Receptor Antagonists; D004873:Ergolines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D004298:Dopamine