title: Independent associations among maternal alcohol consumption and infant thyroxine levels and pregnancy outcome.
abstract: Studies with animal models of alcohol-related birth defects (ARBDs) suggest that reductions in circulating thyroid hormones, including thyroxine (T4), may be a persistent postnatal effect of fetal alcohol exposure. The few clinical reports of children with fetal alcohol syndrome (FAS) that address thyroid system function generally reported that FAS children have thyroid hormone levels within normal limits. For the current study, data bases from the Fetal Alcohol Research Center and the Michigan Department of Public Health Newborn Screening Program were assessed to correlate measures of maternal drug use during pregnancy and infant outcome (gestational age at birth, birthweight, "fetal growth"), with infant whole-blood T4 levels. Multiple regression analyses accounted for demographic factors, infant age at testing, and variation in the T4 assay. As expected, alcohol intake and smoking each had a substantial negative impact on birthweight, gestational age at birth, and fetal growth, assessed as birthweight corrected for gestational age. Infant T4 levels were positively related to birthweight and gestational age and were more strongly related to fetal growth. Infant T4 levels were not influenced significantly by either maternal smoking or alcohol consumption. Smoking- and alcohol-related reductions in birthweight, gestational age, or fetal growth were not associated significantly with variations in infant T4. Interesting questions remain regarding species differences and the influences of maternal alcohol consumption on T4 metabolism as a mechanism for ARBDs. However, the current data do not support the hypothesis that maternal alcohol consumption, or smoking, during pregnancy leads to compromised thyroid system function in newborn humans.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Obstetrics & Gynecology, Wayne State University, School of Medicine, C.S. Mott Center for Human Growth and Development, Detroit, Michigan 48201, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Hannigan
authors.forename: S S
authors.initials: SS
authors.lastname: Martier
authors.forename: J M
authors.initials: JM
authors.lastname: Naber
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects; D044383:Black People; D002648:Child; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000097:blood* / Q000517:prevention & control; D005312:Fetal Blood / Q000378:metabolism*; D005317:Fetal Growth Retardation / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008875:Middle Aged; D015997:Neonatal Screening; D011247:Pregnancy; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013974:Thyroxine / Q000097:blood*
chemical_list: D013974:Thyroxine