The prognosis for live birth among untreated infertile couples.
OBJECTIVE
To estimate the likelihood of live birth and the impact of prognostic factors among untreated infertile couples.


METHODS
Cohort follow-up study.


METHODS
Eleven infertility clinics in academic medical centers.


METHODS
Two thousand one hundred ninety-eight couples with infertility of > 1 year in duration. Untreated months of observations on 873 untreated couples (18,364 months) were combined with observations before the first treatment among 1,325 treated couples (9,761 months).


METHODS
Diagnostic tests as indicated.


METHODS
Time to conception for live birth; effect of baseline characteristics estimated by means of proportional hazards analysis.


RESULTS
There were 263 live birth conceptions during 28,125 months of untreated observations. The cumulative rate of conceptions leading to live birth was 14.3% at 12 months. The relevant prognostic factors were pregnancy history, duration of infertility, female partner's age, male defect, endometriosis, and tubal disease. A prediction score based on these factors would be accurate in approximately 62% of cases.


CONCLUSIONS
The estimation of live birth among untreated infertile couples is sufficiently accurate to be useful in the clinical management of infertility and in the planning of clinical trials.
Collins
J A
JA
Department of Obstetrics and Gynecology, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Burrows
E A
EA
Wilan
A R
AR
D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007246:Infertility / Q000503:physiopathology*; D007743:Labor, Obstetric; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D016016:Proportional Hazards Models