title: [Decrease in common carotid artery intimal thickness after hypolipemic therapy].
abstract: BACKGROUND
  In recent years evidence was provided that it is possible to assess sonographically the thickness of the intima of the common carotid artery, whereby an increase of the thickness of the intima is considered an early stage of atherosclerosis. In the submitted work the authors tried to assess whether it is possible to influence the thickness of the intima by therapy.
  
  
  RESULTS
  In 32 patients with familial hyperlipoproteinaemia sonographic control examinations of the common carotid artery were performed after 27 months of comprehensive treatment. In 21 subjects with familial hypercholesterolaemia the thickness of the intima decreased from 0.83 mm to 0.68 mm (p < 0.01), in 8 subjects with familial combined hyperlipoproteinaemia from 0.77 mm to 0.74 mm (a decline was recorded in half the subjects). In the whole group the greatest decrease was recorded in subjects treated with statins and a smaller decrease in those treated with fibrates.
  
  
  CONCLUSIONS
  The authors assume that the decrease of the thickness of the intima of the common carotid artery recorded in hyperlipoproteinaemic patients after hypolipidaemic treatment is a manifestation of regression of atherosclerosis.
authors.affiliation: III. interní klinika VFN a l. LF UK, Praha.
authors.forename: J
authors.initials: J
authors.lastname: Spácil
authors.forename: R
authors.initials: R
authors.lastname: Ceska
authors.forename: J
authors.initials: J
authors.lastname: Sobra
authors.forename: J
authors.initials: J
authors.lastname: Petrásek
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000150:complications / Q000473:pathology*; D017536:Carotid Artery, Common / Q000473:pathology*; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017539:Tunica Intima / Q000473:pathology*
vernacular_title: Zmensení tloustky intimy arteria carotis communis pri hypolipidemické lécbĕ.