title: Fever in uncomplicated Plasmodium falciparum infection: effects of quinine and paracetamol.
abstract: The effects of quinine and paracetamol on fever were studied in 21 adult patients with acute uncomplicated falciparum malaria. Quinine alone (n = 7) had no significant effect on fever, whereas paracetamol given 2 h after quinine (n = 7) or 2 h before quinine (n = 7) reduced temperature by a mean of 2.1 degrees C (standard deviation [SD] 0.95) and 2.1 degrees C (SD 0.79) respectively. A temperature reduction of 1 degree C was associated with a mean decrement of 9.7 beats/min (SD 3.3) in the pulse rate. Quinine does not possess useful antipyretic activity.
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Krishna
authors.forename: W
authors.initials: W
authors.lastname: Supanaranond
authors.forename: S
authors.initials: S
authors.lastname: Pukrittayakamee
authors.forename: F
authors.initials: F
authors.lastname: ter Kuile
authors.forename: Y
authors.initials: Y
authors.lastname: Supputamangkol
authors.forename: K
authors.initials: K
authors.lastname: Attatamsoonthorn
authors.forename: M
authors.initials: M
authors.lastname: Ruprah
authors.forename: N J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D001831:Body Temperature / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D016778:Malaria, Falciparum / Q000150:complications*; D008297:Male; D011803:Quinine / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000082:Acetaminophen; D011803:Quinine