[Fatal course of infectious mononucleosis in an 11-month-old girl].
Fatal infectious mononucleosis is vary rare in the human population. Only two case reports of girls suffering an Epstein-Barr virus-associated lymphoproliferation without evidence of an underlying immunodeficiency came to our knowledge. We report on the case of an 11-months-old girl with fatal infectious mononucleosis. Some findings allow distinct delineation from previous reports. Firstly, the present "pulmonary lymphoid hyperplasia" has been formerly described in patients with HIV infection exclusively. Secondly, only the EBV surface antigen LMP was expressed on infected B-cells. The nuclear antigen complex EBNA could not be demonstrated. Overall, the results suggest a so far unrecognised type of EBV-associated lymphoproliferation in a female infant.
Lackmann
G M
GM
Klinik für Kinder- und Jugendmedizin, Städtisches Klinikum Fulda.
Töllner
U
U
Schauer
U
U
Kraft
U
U
Rieger
C
C
D001402:B-Lymphocytes / Q000276:immunology; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D006965:Hyperplasia; D007223:Infant; D007244:Infectious Mononucleosis / Q000276:immunology / Q000473:pathology*; D008168:Lung / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016131:Lymphocyte Subsets / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000473:pathology*
Tödliche Verlaufsform einer infektiösen Mononukleose bei einem 11 Monate alten Mädchen.