title: Cyclic GMP levels in the rat brain and plasma during clinical death and after resuscitation.
abstract: Changes of cGMP content in the rat brain and plasma have been evaluated by means of the radioimmunologic method after 5-min clinical death and up to 2 hours after resuscitation. Ischemia produced a decrease of cGMP in the brain, however, at the 15th min after resuscitation a reversible significant rise of nucleotide concentration was noted. In plasma at the end of ischemia and in the postischemic period a significant decrease of cGMP level was observed. The mechanisms of cGMP regulation in the central nervous system and the significance of the obtained results are discussed.
authors.affiliation: Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
authors.forename: A
authors.initials: A
authors.lastname: Kapuściński
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D001926:Brain Death; D005260:Female; D006157:Guanosine Monophosphate / Q000032:analysis* / Q000097:blood*; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012151:Resuscitation; D013997:Time Factors
chemical_list: D006157:Guanosine Monophosphate