Interferon-alpha (INF-alpha) and etretinate in the treatment of mycosis fungoides.
A combination therapy of mycosis fungoides (MF) with interferon-alpha (INF-alpha) and etretinate was reported. A 53-year-old patient suffering from MF was treated with intramuscular administration of INF-alpha at a dosage of 9 x 10(6) IU daily; skin lesions poorly responded to the treatment. After oral etretinate with a dosage of 50 mg daily was combined with INF-alpha, marked clinical improvement was seen in skin lesions with minor side effects. INF-alpha in combination with etretinate can have beneficial effects in the treatment of MF.
Torii
H
H
Department of Dermatology, Kanto Teishin Hospital, Japan.
Kaneko
T
T
Matsuyama
T
T
Nakanishi
H
H
Harada
S
S
D000284:Administration, Oral; D003131:Combined Modality Therapy; D005050:Etretinate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy* / Q000532:radiotherapy / Q000628:therapy*; D009364:Neoplasm Recurrence, Local; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000628:therapy*
D016898:Interferon-alpha; D005050:Etretinate