title: Experimental supplemental vein grafting and hypoperfusion syndrome.
abstract: An additional saphenous vein graft (SVG) sometimes is required to the same coronary system if acute internal thoracic artery (ITA) graft flow is inadequate. These experiments were conducted to determine the consequences produced by ITA-SVG dual grafting. Fourteen dogs each received two coronary grafts (without bypass, using local occlusion) to the proximal circumflex coronary artery, using the ITA and an SVG, and then the circumflex artery was ligated proximally. Simultaneous flow in both grafts was determined at rest and after pharmacologic (adenosine, phenylephrine) or physiologic (cardiac pacing) stimulation. Serial angiography was performed during the first 4 weeks after grafting to determine patency patterns of the ITAs and SVGs. In the resting heart, flow was 7.5 +/- 1.6 mL/min (17.5%) in the ITA graft and 35.3 +/- 5.2 mL/min (82.5%) in the SVG (mean +/- standard deviation [% total distal perfusion]), and the combined flow was not significantly different from the original native flow. Intravenous adenosine (0.2 mg.kg-1.min-1) preferentially increased both the total ITA flow and its fractional contribution to total distal perfusion (18.4 +/- 3.2 [31.1%]; p < 0.05 versus rest). Saphenous vein graft flow was not changed significantly (40.3 +/- 6.0 mL/min), in part due to a modest decrease in arterial pressure. In contrast, intravenous phenylephrine (0.003 mg.kg-1.min-1) decreased both absolute ITA flow and its relative contribution to distal perfusion (6.1 +/- 1.1 [10.9%]; p < 0.05 versus rest), despite an increased systemic perfusion pressure, which increased SVG flow significantly (50.1 +/- 4.8 [89.1%]; p < 0.05 versus rest).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, East Carolina University School of Medicine, Greenville, NC 27858-4354, USA.
authors.forename: M
authors.initials: M
authors.lastname: Otaki
authors.forename: R M
authors.initials: RM
authors.lastname: Lust
authors.forename: Y S
authors.initials: YS
authors.lastname: Sun
authors.forename: T O
authors.initials: TO
authors.lastname: Norton
authors.forename: D T
authors.initials: DT
authors.lastname: Rock
authors.forename: P A
authors.initials: PA
authors.lastname: Spence
authors.forename: W R
authors.initials: WR
authors.lastname: Chitwood
mesh_terms: D000241:Adenosine; D000818:Animals; D001783:Blood Flow Velocity; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D003326:Coronary Circulation; D004195:Disease Models, Animal; D004285:Dogs; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000503:physiopathology*; D010656:Phenylephrine; D012501:Saphenous Vein / Q000637:transplantation*; D013577:Syndrome; D013895:Thoracic Arteries / Q000637:transplantation*; D014654:Vascular Patency
chemical_list: D010656:Phenylephrine; D000241:Adenosine