Rheumatic manifestations in patients with myelodysplastic and myeloproliferative diseases.
OBJECTIVE
To evaluate the rheumatic complications in patients with myelodysplastic and myeloproliferative diseases.


METHODS
A retrospective chart review of patients with a rheumatic disease and either a myelodysplastic or myeloproliferative disorder diagnosed on bone marrow examination.


RESULTS
Nine patients were identified, 5 with myelodysplastic and 4 with myeloproliferative disorders. Polyarthritis was the most common rheumatic presentation, occurring in 6 patients with a positive rheumatoid factor in 4. Necrotizing vasculitis complicated the course in 3 patients. Autoantibodies and hypergammaglobulinemia were present in the majority of patients.


CONCLUSIONS
There is an association between hematologic disorders caused by proliferation of bone marrow derived pluripotent stem cells and rheumatic disorders.
Kuzmich
P V
PV
Division of Rheumatology, Ottawa General Hospital, University of Ottawa, ON, Canada.
Ecker
G A
GA
Karsh
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000209:etiology; D001172:Arthritis, Rheumatoid / Q000209:etiology; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000473:pathology; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000473:pathology; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000209:etiology*; D014657:Vasculitis / Q000209:etiology