Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12-->q13.
We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12-->q13.
Carow
C E
CE
Oncology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kim
E
E
Hawkins
A L
AL
Webb
H D
HD
Griffin
C A
CA
Jabs
E W
EW
Civin
C I
CI
Small
D
D
D000818:Animals; D001483:Base Sequence; D001853:Bone Marrow; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D017931:DNA Primers; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics; D051941:fms-Like Tyrosine Kinase 3
D017931:DNA Primers; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; C497970:FLT3 protein, human; C497971:Flt3 protein, mouse; D020794:Receptor Protein-Tyrosine Kinases; D051941:fms-Like Tyrosine Kinase 3