Accidental intravenous administration of 50 mg of racemic adrenaline in a 2-year-old boy.
A 2-year-old boy received, by mistake, 50 mg racemic adrenaline intravenously, equivalent to 1.8 mg kg-1 of L-adrenaline. The blood pressure increased to 160/105 mmHg, the heart rate to 160 beats min-1, and pulmonary oedema developed over the next 2 h. He was treated with nitroprusside, nitroglycerin and digitoxin, and was intubated and ventilated. After 3 h a hypotensive phase occurred which required infusions of very high concentrations of catecholamines for 72 h. Renal failure required renal transplantation after which the child made an uneventful recovery.
Dybvik
T
T
Department of Anaesthesiology, Ullevål University Hospital, Oslo, Norway.
Halvorsen
P
P
Steen
P A
PA
D058186:Acute Kidney Injury / Q000139:chemically induced; D002675:Child, Preschool; D062787:Drug Overdose; D004837:Epinephrine / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008508:Medication Errors; D011041:Poisoning / Q000628:therapy; D064705:Racepinephrine
D064705:Racepinephrine; D004837:Epinephrine