title: Trials of Hypertension Prevention, phase II. Structure and content of the weight loss and dietary sodium reduction interventions. Trials of Hypertension Prevention (TOHP) Collaborative Research Group.
abstract: Identifying effective, nonpharmacologic means of preventing or significantly delaying the onset of hypertension would be a major advance in the primary prevention of cardiovascular disease. In the first phase of the Trials of Hypertension Prevention (TOHP I), adults with high-normal diastolic blood pressure were randomly assigned to one of seven nonpharmacologic interventions. Only weight loss and reduction of dietary sodium proved to be effective strategies for reducing blood pressure. The second phase of TOHP (TOHP II) will test the effectiveness of weight loss, reduction of dietary sodium, and their combination of lowering blood pressure and preventing the onset of hypertension over a 3- to 4-year follow-up period. This article describes the three interventions used in TOHP II, methods used to maintain continued participation in this long-term trial, and protocol enhancements designed to maximize intervention effectiveness.
authors.affiliation: New Jersey Medical School, Newark, USA.
authors.forename: V I
authors.initials: VI
authors.lastname: Lasser
authors.forename: J M
authors.initials: JM
authors.lastname: Raczynski
authors.forename: V J
authors.initials: VJ
authors.lastname: Stevens
authors.forename: M K
authors.initials: MK
authors.lastname: Mattfeldt-Beman
authors.forename: S
authors.initials: S
authors.lastname: Kumanyika
authors.forename: M
authors.initials: M
authors.lastname: Evans
authors.forename: E
authors.initials: E
authors.lastname: Danielson
authors.forename: A
authors.initials: A
authors.lastname: Dalcin
authors.forename: D M
authors.initials: DM
authors.lastname: Batey
authors.forename: L K
authors.initials: LK
authors.lastname: Belden
mesh_terms: D000328:Adult; D001794:Blood Pressure; D017321:Clinical Trials, Phase I as Topic; D003131:Combined Modality Therapy; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000517:prevention & control*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012107:Research Design; D012982:Sodium, Dietary / Q000008:administration & dosage; D015431:Weight Loss
chemical_list: D012982:Sodium, Dietary