title: The use of long-term acid-suppression therapy.
abstract: Drug therapy to suppress gastric acid secretion is commonly used in the management of dyspepsia, many patients taking such therapy over long periods of time. An audit of patients on long-term (> 12 months) acid-suppression therapy was carried out in the two practices providing primary healthcare to a town in Northeast England. Patients on continuous therapy (> 10 months' supply in the previous year) and intermittent therapy (6-10 months' supply in the previous year) were identified through computerised prescribing records. Their written and computer records were scrutinised to determine diagnosis, duration of therapy, use of NSAIDs and other features. A total of 365 patients were identified (208 men, 157 women): 132 were on intermittent and 233 on continuous therapy. Of the total, 83% were over 45 years and one-fifth were taking NSAIDs. Of the 310 patients investigated for their dyspepsia, only 250 had a positive diagnosis, of which duodenal ulcer (154) was the most common.
authors.affiliation: Thornaby Health Centre, Middlesbrough.
authors.forename: G P
authors.initials: GP
authors.lastname: Rubin
authors.forename: B
authors.initials: B
authors.lastname: Contractor
authors.forename: M G
authors.initials: MG
authors.lastname: Bramble
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D017442:Histamine Agonists / Q000627:therapeutic use; D006801:Humans; D008134:Long-Term Care; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D017442:Histamine Agonists; D011899:Ranitidine; D009853:Omeprazole