Quantitative combined phosphorus and proton PRESS of the brains of newborn human infants.
Techniques for quantitative, combined phosphorus and proton, point-resolved spectroscopy (PRESS) studies of newborn-infant brain have been developed. Phosphorus PRESS advantages include: voxel-shimming; rapid transmitter-pulse setting; novel use of brain-water as a localized quantitation reference; and reduced broad components. Proton spectra from 1-ml voxels and phosphorus spectra can both be acquired quantitatively within acceptable time. Cerebral lactate was consistently detected by proton PRESS and the normal concentration (approximately 3 mmol/kg wet weight) may be higher than in adult brain. Phosphorus PRESS provided metabolite peak-area ratios and concentrations comparable with those obtained using ISIS.
Cady
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Department of Medical Physics and Bio-Engineering, University College London Hospitals NHS Trust, United Kingdom.
D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D006801:Humans; D007231:Infant, Newborn; D007773:Lactates / Q000032:analysis; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D010759:Phosphorus Isotopes
D007773:Lactates; D010759:Phosphorus Isotopes; D019344:Lactic Acid