[A case of pulmonary aspergillosis effectively treated with itraconazole. Possible interaction of the antimycotic agent with hydroquinidine].
This study describes a case of pulmonary aspergilloma in a neutropenic patient affected with myelodysplastic syndrome. It reports the therapeutic efficacy of itraconazole, emphasizing in particular the possible interaction with quinidine, with QT prolongation--at ECG--disappeared after quinidine withdrawal.
Cruccu
V
V
Divisione Medica III, Ospedale Fatebenefratelli, Milano.
Pedretti
D
D
Confalonieri
F
F
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001919:Bradycardia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D004347:Drug Interactions; D004562:Electrocardiography; D017964:Itraconazole / Q000627:therapeutic use*; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000188:drug therapy; D009503:Neutropenia / Q000150:complications; D011802:Quinidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013902:Radiography, Thoracic
D000889:Anti-Arrhythmia Agents; D000935:Antifungal Agents; D017964:Itraconazole; C014486:hydroquinidine; D011802:Quinidine
Un caso di aspergillosi polmonare trattato efficacemente con itraconazolo. Possibile interferenza dell'antimicotico con la idrochinidina.