t(8;21) myelodysplasia, an early presentation of M2 AML.
The reciprocal translocation of genetic material between chromosomes 8 and 21, t(8;21), is usually restricted to cases of acute myeloid leukaemia (AML). Cases of AML with t(8;21) exhibit characteristic dysplastic features in myeloid and erythroid lineages with reduction in megakaryocytes. We report details of three patients presenting with myelodysplastic features; two had a typical t(8;21), and the third had a variant t(8;21) translocation. We discuss the significance of t(8;21) in the aetiology of myelodysplastic syndrome (MDS) and implications for the management of such patients.
Taj
A S
AS
Royal South Hants Hospital, Southampton.
Ross
F M
FM
Vickers
M
M
Choudhury
D N
DN
Harvey
J F
JF
Barber
J C
JC
Barton
C
C
Smith
A G
AG
D000328:Adult; D015139:Blotting, Southern; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014178:Translocation, Genetic