title: Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects.
abstract: The effects of age and gender on the pharmacokinetics of high-dose intravenous ciprofloxacin in a healthy volunteer study were investigated. Plasma ciprofloxacin concentrations were higher in the elderly than in the young, and the pharmacokinetic parameters were not significantly different between the genders. Ciprofloxacin was well tolerated, with the majority of adverse events related to local reactions at the IV site.
authors.affiliation: Miles Inc., West Haven, Connecticut 06516, USA.
authors.forename: A
authors.initials: A
authors.lastname: Shah
authors.forename: J
authors.initials: J
authors.lastname: Lettieri
authors.forename: D
authors.initials: D
authors.lastname: Nix
authors.forename: J
authors.initials: J
authors.lastname: Wilton
authors.forename: A H
authors.initials: AH
authors.lastname: Heller
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D012737:Sex Factors
chemical_list: D002939:Ciprofloxacin