title: The predictive value of T cell function in vitro and pre-AIDS zidovudine use for survival after AIDS diagnosis in a cohort of homosexual men in Amsterdam.
abstract: The best independent predictors of survival after AIDS diagnosis were determined in 160 homosexual men from the Amsterdam Cohort Study (1987 CDC case definition). In a Cox model, all pre-AIDS laboratory markers gathered during follow-up in the study did not independently predict survival after AIDS. A second analysis, using data available only at AIDS diagnosis, revealed that T cell reactivity after stimulation with phytohemagglutinin and monoclonal CD3 antibodies and the CD4+ cell count at diagnosis were independent predictors of survival. In an interval-based Cox model, the predictive value of pre-AIDS zidovudine use was determined. One year after AIDS diagnosis, participants with pre-AIDS zidovudine use had a worse survival probability (relative hazard = 3.99). In conclusion, the survival probability of homosexual men with AIDS can be estimate adequately using information obtained at clinical AIDS diagnosis. Analysis revealed the important predictive value of T cell function tests in vitro.
authors.affiliation: Department of Public Health, Amsterdam, Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Bindels
authors.forename: A
authors.initials: A
authors.lastname: Krol
authors.forename: M
authors.initials: M
authors.lastname: Roos
authors.forename: J
authors.initials: J
authors.lastname: Veenstra
authors.forename: J A
authors.initials: JA
authors.lastname: van den Hoek
authors.forename: F
authors.initials: F
authors.lastname: Miedema
authors.forename: R A
authors.initials: RA
authors.lastname: Coutinho
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology*; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D015703:Antigens, CD / Q000032:analysis; D015415:Biomarkers; D016516:CD4-CD8 Ratio; D002478:Cells, Cultured; D015331:Cohort Studies; D005500:Follow-Up Studies; D006678:HIV / Q000302:isolation & purification; D006679:HIV Seropositivity / Q000188:drug therapy* / Q000276:immunology* / Q000401:mortality; D018451:Homosexuality, Male; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D015999:Multivariate Analysis; D009426:Netherlands; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D015215:Zidovudine