[The role of platelet activating factor in mesenterioangial microcirculatory disturbance complicated with acute pancreatitis in rats].
To study shock in early acute pancreatitis (AP), we observed the change of mesenterio-angial microcirculation in the rat with AP induced by sodium taurocholate infused into the pancreatic duct. Meanwhile, the effect of platelet activating factor (PAF) receptor antagonist BN52021 upon the animal with AP was also investigated. 18 Sprague-Dawley rats were divided into three groups: pancreatitis group pan + BN52021 group and control group. pan + BN52021 group was injected BN52021 (10mg/kg) intravenously 5 minutes and 180 minutes after AP induction. The other groups were injected normal saline. We also studied the survival times of rats. The results showed slow mesenterio-angial small arteriolar and venular blood flow velocity and dilated meseaterio-angial small venular diameter during the early phase of AP. An protective effect of BN52021 on mesenterio-angial microcirculation injuries accompanied by AP was confirmed Animals treated with BN52021 survived 458.3 +/- 9.5 minutes whereas death occurred 243.3 +/- 2.3 minutes after AP induction in untreated rats (P < 0.01).
Ji
Z
Z
Department of Hepatopancreato-Biliary Surgery, General Naval Hospital, Beijing.
Wang
B
B
Li
S
S
D000208:Acute Disease; D000818:Animals; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones / Q000494:pharmacology; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010195:Pancreatitis / Q000139:chemically induced / Q000150:complications*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012772:Shock, Septic / Q000097:blood; D013152:Splanchnic Circulation / Q000187:drug effects; D013656:Taurocholic Acid
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D013656:Taurocholic Acid; C045856:ginkgolide B