title: [Transdermal estradiol--the possibility for replacement therapy in the postmenopause].
abstract: The author presents his experience in the treatment of 21 early postmenopausal women (mean age of 49.2 yrs) with transdermal delivery of 17 beta-oestradiol (Estraderm TTS, Ciba). During the treatment Kuppermann index falls from 28.5 to 10.9. Karyopyknotic index increases from 6.8 to 23.4 and maturation index moves from 39:52:9 to 0:71:29. Genital bleeding occurs in 52% of the patients. The author concludes that the treatment with transdermal delivery of oestradiol could be used more widely for replacement therapy in the postmenopause.
authors.forename: E
authors.initials: E
authors.lastname: Rachev
mesh_terms: D000279:Administration, Cutaneous; D002979:Climacteric / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage* / Q000009:adverse effects; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects*
chemical_list: D004958:Estradiol
vernacular_title: Transdermalen estradiol--vŭzmozhnost za zamestitelna terapiia v postmenopauzata.