A soluble form of tumour necrosis factor receptor in cerebrospinal fluid and serum of HTLV-I-associated myelopathy and other neurological diseases.
Paired samples of cerebrospinal fluid (CSF) and serum from 17 patients with human T-cell lymphotrophic virus I (HTLV-I)-associated myelopathy, 5 patients with multiple sclerosis and 11 controls with non-inflammatory disorders (migraine, idiopathic epilepsy and myelopathy of unknown aetiology) were examined by enzyme-linked immunosorbent assay for the presence of the 60-kDa soluble form of tumour necrosis factor receptor (sTNF-R). The results were compared with blood-CSF barrier function, cell count and the intrathecal synthesis of HTLV-I antibodies. No correlation could be demonstrated. High levels of sTNF-R were found in CSF of patients with HTLV-I-associated myelopathy and multiple sclerosis. In addition, intrathecal sTNF-R was also detected in the patients with non-inflammatory diseases, indicating that sTNF-R is definitively a normal constituent of CSF.
Puccioni-Sohler
M
M
Klinik und Poliklinik für Neurologie, Georg-August-Universität, Göttingen, Germany.
Rieckmann
P
P
Kitze
B
B
Lange
P
P
Albrecht
M
M
Felgenhauer
K
K
D001812:Blood-Brain Barrier; D002452:Cell Count; D002493:Central Nervous System Diseases / Q000097:blood* / Q000134:cerebrospinal fluid*; D015481:HTLV-I Antibodies / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid*; D015493:Paraparesis, Tropical Spastic / Q000097:blood* / Q000134:cerebrospinal fluid*; D018124:Receptors, Tumor Necrosis Factor / Q000032:analysis*; D012995:Solubility
D015481:HTLV-I Antibodies; D018124:Receptors, Tumor Necrosis Factor