The synaptic vesicle cycle: a cascade of protein-protein interactions.
The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neurotransmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all cellular transport pathways, the synaptic vesicle cycle is the fastest and the most tightly regulated. A convergence of results now allows formulation of molecular models for key steps of the cycle. These developments may form the basis for a mechanistic understanding of higher neural function.
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Department of Molecular Genetics, University of Texas Southwestern Medical School, Dallas 75235, USA.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology; D002135:Calcium-Binding Proteins; D004705:Endocytosis; D005089:Exocytosis; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D008561:Membrane Fusion; D008562:Membrane Glycoproteins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009473:Neuronal Plasticity; D013572:Synaptic Vesicles / Q000187:drug effects / Q000502:physiology*; D050857:Synaptotagmins; D020692:rab3 GTP-Binding Proteins
D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D050857:Synaptotagmins; D019204:GTP-Binding Proteins; D020692:rab3 GTP-Binding Proteins