Effects of clinofibrate on plasma fibrinogen level in high fructose diet-induced hyperlipidemic rats.
Effects of clinofibrate on the coagulative and fibrinolytic activity in an intrinsic hyperlipidemia induced by a cholesterol free-high fructose diet (HFD) for 14 days were studied using male Wistar rats. There were significant and positive correlations between plasma fibrinogen level and serum lipid content, and between fibrinogen level and VLDL-LDL-lipid content. Clinofibrate administration (50 and 100 mg/kg/day, p.o.) significantly inhibited the increase in plasma fibrinogen level as well as serum- and VLDL-LDL-lipids. It is concluded that clinofibrate, in addition to its beneficial effect on the serum lipid profile, can effectively reduce the plasma fibrinogen level.
Okazaki
M
M
Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan.
Zhang
H
H
Ichino
K
K
Amamiya
M
M
Nakayama
S
S
Oguchi
K
K
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001835:Body Weight; D004040:Dietary Carbohydrates; D005340:Fibrinogen / Q000378:metabolism*; D005342:Fibrinolysis / Q000187:drug effects; D005632:Fructose; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010642:Phenoxyacetates / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D004040:Dietary Carbohydrates; D000960:Hypolipidemic Agents; D010642:Phenoxyacetates; C006231:clinofibrate; D005632:Fructose; D005340:Fibrinogen