HLA in familial and nonfamilial Mediterranean Kaposi's sarcoma in Greece.
Fifty-four (54) unrelated patients with Mediterranean Kaposi's sarcoma (MKS) and 8 patients members of 4 unrelated families with familial MKS were serotyped for HLA-A,B and DR antigens. The diagnosis was histologically confirmed and all patients were negative for anti-HIV antibodies. An increased frequency of HLA-B18 (44.4% vs 14.2% in the controls, p < 0.001, RR = 4.8) and HLA-DR5 (57.6% vs 37.2% in the controls, p < 0.025, RR = 2.29) was observed in the group of patients with MKS. Seven (7) of the 8 family members with FMKS possessed HLA-DR5, and the affected members in the 3 families shared a common haplotype which included HLA-DR5. These findings support the hypothesis that genetic factors linked to HLA-DR5 antigen may contribute to the pathogenesis of MKS.
Kaloterakis
A
A
Second Department of Medicine, University of Athens Medical School, Greece.
Papasteriades
C
C
Filiotou
A
A
Economidou
J
J
Hadjiyannis
S
S
Stratigos
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006115:Greece / Q000453:epidemiology; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015805:HLA-DR5 Antigen / Q000032:analysis / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012514:Sarcoma, Kaposi / Q000145:classification / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
D006680:HLA Antigens; D015805:HLA-DR5 Antigen