title: [A case of secondary carnitine deficiency due to anorexia nervosa and severe liver damage].
abstract: We reported an 18-year-old woman with anorexia nervosa and liver damage who showed carnitine deficiency. Her unbalanced diet had little carnitine, and severely damaged liver could not synthesize carnitine. Since total parenteral nutrition (TPN) and tube-feed formulas contain little or no carnitine, the patient had progressive weakness and muscle atrophy. Muscle biopsy revealed variability of fiber diameter, type 1 fiber atrophy and copious amount of lipid granules. Carnitine deficiency must be diagnosed in the early stage by muscle biopsy or muscle carnitine levels, and treated with oral intake of L-carnitine.
authors.affiliation: Department of Neurology, Yamaguchi University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Fukusako
authors.forename: K
authors.initials: K
authors.lastname: Negoro
authors.forename: N
authors.initials: N
authors.lastname: Tsuda
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Morimatsu
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000150:complications*; D002331:Carnitine / Q000172:deficiency*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*
chemical_list: D002331:Carnitine