title: Invasive Haemophilus influenzae disease: epidemiology and clinical spectrum before large-scale H. influenzae type b vaccination.
abstract: In a prospective study between January 1987 and December 1992, 103 patients with invasive Haemophilus influenzae (Hi) infection were identified in a well-defined population before large-scale Haemophilus influenzae type b (Hib) vaccination was introduced. The incidence (case/100,000/year) of invasive Hi infection was 5.9 for the whole population, 55 for children 0-4 years old and as high as 2.8 for adults. Hib was the predominant cause of the infection (83 cases) in children but, in adults, 13/39 (30%) cases were caused by non-typable Hi and 6/39 (19%) by Hi serotype f. Three patients (3%) died and 6 (5.8%) suffered a permanent sequel from the infection. All patients with such a sequel had invasive Hib infection. No significant difference between patients 0-6 years old and matched controls regarding the frequency of subnormal serum levels of immunoglobulins was found.
authors.affiliation: Department of Otorhinolaryngology, Orebro Medical Center Hospital, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Hugosson
authors.forename: S A
authors.initials: SA
authors.lastname: Silfverdal
authors.forename: O
authors.initials: O
authors.lastname: Garpenholt
authors.forename: E
authors.initials: E
authors.lastname: Esbjörner
authors.forename: B
authors.initials: B
authors.lastname: Lindquist
authors.forename: T
authors.initials: T
authors.lastname: Vikerfors
authors.forename: B
authors.initials: B
authors.lastname: Werner
authors.forename: P
authors.initials: P
authors.lastname: Olcén
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004826:Epiglottitis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D018073:Haemophilus Vaccines; D006193:Haemophilus influenzae / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D008875:Middle Aged; D011446:Prospective Studies; D012703:Serotyping; D013548:Sweden / Q000453:epidemiology
chemical_list: D018073:Haemophilus Vaccines; D007136:Immunoglobulins