title: [Assessment of the sensitivity to antifungal agents of clinical isolates of Candida albicans serotype A and B by the ATB Fungus method].
abstract: BACKGROUND
  Candida albicans is the most frequently species isolated in patients with candidiasis. This species may be antigenically divided in serotypes A and B, which have a different pathogenic behavior and antifungal susceptibility pattern.
  
  
  METHODS
  The antifungal susceptibility of 443 clinical isolates from both serotypes of C. albicans to 5-fluorocytosine (5FC), amphotericin B, nystatin, econazole, miconazole and ketoconazole has been tested by means of the ATB Fungus method.
  
  
  RESULTS
  Both serotypes showed a similar in vitro susceptibility to amphotericin B, nystatin, econazole, miconazole and ketoconazole. All the isolates were susceptible to amphotericin B and nystatin. A small number of in vitro resistant isolates were observed to azole compounds. However, serotype B was significantly more resistant than serotype A (p = 0.0001) to 5FC.
  
  
  CONCLUSIONS
  C. albicans serotype B shows a lower susceptibility than serotype A to 5FC, an antifungal product not marketed in Spain. Serotyping of C. albicans does not offer additional information on antifungal susceptibility of clinical isolates from this species.
authors.affiliation: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao.
authors.forename: G
authors.initials: G
authors.lastname: Quindós
authors.forename: R
authors.initials: R
authors.lastname: San Millán
authors.forename: A
authors.initials: A
authors.lastname: Burgos
authors.forename: V
authors.initials: V
authors.lastname: Lipperheide
authors.forename: M
authors.initials: M
authors.lastname: Tellaetxe
authors.forename: R
authors.initials: R
authors.lastname: Alonso
authors.forename: B
authors.initials: B
authors.lastname: Barturen
authors.forename: J
authors.initials: J
authors.lastname: Pontón
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000145:classification / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D012703:Serotyping
chemical_list: D000935:Antifungal Agents
vernacular_title: Evaluación de la sensibilidad a los antifúngicos de aislamientos clínicos de los serotipos A y B de Candida albicans mediante el método ATB Fungus.