title: Effect of radiofrequency catheter ablation on calcium channel of ventricular myocytes.
abstract: Using whole-cell patch-clamp technique, the effect of radiofrequency catheter ablation (RFCA) on calcium current (Ica) of guinea pig ventricular myocytes was examined. The radiofrequency energy delivered was 20 W x 10 s. RF-CA decreased Ica apparently with the affected area reaching up to 1.2 cm from the ablation focus. In the meanwhile, the pathological lesion size resulted from RFCA was merely 0.41 +/- 0.11 cm. These findings indicate that RFCA, apart from causing tissue necrosis by heat, can affect myocyte membrane currents in a large area. This may explain why RFCA has a very high success rate with a small pathological lesion.
authors.affiliation: Department of Internal Medicine, Tongji Hospital, Tongji Medical University, Wuhan.
authors.forename: Y G
authors.initials: YG
authors.lastname: Wang
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Lu
authors.forename: H Y
authors.initials: HY
authors.lastname: Zhao
authors.forename: M
authors.initials: M
authors.lastname: Tang
authors.forename: Q H
authors.initials: QH
authors.lastname: Liu
mesh_terms: D000818:Animals; D015220:Calcium Channels; D017115:Catheter Ablation; D006224:Cricetinae; D006352:Heart Ventricles / Q000601:surgery; D009206:Myocardium / Q000166:cytology*; D018408:Patch-Clamp Techniques; D012032:Refractory Period, Electrophysiological
chemical_list: D015220:Calcium Channels