[A comparative study of the anticonvulsant action of a new table salt substitute].
Murine experiments have demonstrated that excess sodium chloride intake has an aggravating effect on the course of convulsions caused by corazolum, thiosemicarbaside and maximum electric shock rather than strychnine. The new sodium chloride substitute hyposol given to animals ad libitum for a fortnight produces an anticonvulsant effect which is more pronounced in corazolum-induced convulsions and potentiates the anticonvulsant effect of diazepam. The official drug sanasol is antagonistic to strychnine and corazolum, but it displays a proconvulsant activity on a thiosemicarbaside model.
Shtrygol'
D V
DV
Shtrygol'
S Iu
SIu
D000643:Ammonium Chloride / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002125:Calcium Gluconate / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D003292:Convulsants; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010433:Pentylenetetrazole; D011189:Potassium Chloride / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D012663:Semicarbazides; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage; D013331:Strychnine
D000927:Anticonvulsants; D003292:Convulsants; D004338:Drug Combinations; D012663:Semicarbazides; D017673:Sodium Chloride, Dietary; D000643:Ammonium Chloride; C094274:sanasol; C005151:thiosemicarbazide; D011189:Potassium Chloride; D013331:Strychnine; D002125:Calcium Gluconate; D010433:Pentylenetetrazole
Sravnitel'noe issledovanie protivosudorozhnogo deĭstviia novogo zamenitelia povarennoĭ soli.