title: [Usage of the geno-toxicological studies in the biological evaluation of dental materials].
abstract: The salmonella mutagenicity test (Ames test), the Bacillus subtilis repair test and SOS chromotest are three sorts of sort-term mutagenic test, which were developed recently and had their individual terminal point to examine genotoxins. A battery of short-term tests was made up of these three mutagenic tests to examine the mutagenicity of formaldehyde, glutaraldehyde and resorcinal. The results verified formaldehyde and glutaraldehyde were genetoxins, and discovered resorcinal not only had no mutagenicity, but also had the antimutagenicity to some genotoxic agents. In addition, the methods of three tests were described and the use of the battery was introduced and evaluated.
authors.affiliation: School of Stomatology, Beijing Medical University.
authors.forename: L
authors.initials: L
authors.lastname: Yue
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D004260:DNA Repair; D003764:Dental Materials / Q000633:toxicity*; D005557:Formaldehyde / Q000633:toxicity; D005976:Glutaral / Q000633:toxicity; D009152:Mutagenicity Tests; D012118:Resorcinols / Q000633:toxicity; D012387:Root Canal Filling Materials; D013014:SOS Response, Genetics
chemical_list: D003764:Dental Materials; D012118:Resorcinols; D012387:Root Canal Filling Materials; D005557:Formaldehyde; D005976:Glutaral; C031389:resorcinol