[Effectiveness of isoniazid in tuberculosis chemoprophylaxis in children with rising tuberculin sensitivity].
70 children aged 4-15 with growing tuberculin sensitivity received preventive treatment with isoniazid in children's sanatorium. The drug was taken for 2 or 3 months in a dose 10 mg/kg daily (19 and 51 children, respectively). Preventive isoniazid course proved effective as none of the children treated developed tuberculosis within 3 years. The 3-month course is preferable as it is more potent in relation to tuberculin sensitivity immediately after the treatment termination and 1, 2 years after it.
Mitinskaia
L A
LA
Elufimova
V F
VF
Iukhimenko
N V
NV
Demeshko
N D
ND
Zriachkina
L I
LI
Pesnia
N P
NP
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013997:Time Factors; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*
D007538:Isoniazid
Effektivnost' khimioprofilaktiki tuberkuleza izoniazidom u deteĭ s usilivaiushcheĭsia tuberkulinovoĭ chuvstvitel'nost'iu.