Treatment of pyoderma gangrenosum with cultured keratinocyte autografts.
BACKGROUND
Pyoderma gangrenosum is an uncommon chronic skin disease characterized by rapidly enlarging cutaneous ulcers. Immunosuppressive agents, such as corticosteroids, are the mainstay of therapy.


OBJECTIVE
We describe a patient with pyoderma gangrenosum treated with cultured keratinocyte autografts for a full-thickness ulcer located on the dorsal and lateral aspects of the foot.


METHODS
After stabilizing the ulcer with intralesional and systemic corticosteroids, the ulcer was debrided and cultured keratinocyte autografts were secured with nylon mesh. An outer dressing of gauze and elastic bandage was used.


RESULTS
The patient had > 95% "take" of the grafts and the ulcer was fully healed in less than 1 month. The grafted area preserved the clinical phenotype of the palmar skin from which the original biopsy was taken.


CONCLUSIONS
Cultured keratinocyte autografts can provide permanent wound coverage for patients on high doses of immunosuppressive medications.
Límová
M
M
Department of Dermatology, University of California, San Francisco 94136.
Mauro
T
T
D000284:Administration, Oral; D000328:Adult; D001458:Bandages; D002478:Cells, Cultured; D003131:Combined Modality Therapy; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D015552:Injections, Intralesional; D015603:Keratinocytes / Q000637:transplantation*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000601:surgery*; D013526:Surgical Mesh; D014182:Transplantation, Autologous; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use
D014222:Triamcinolone Acetonide; D011241:Prednisone