[Production and some properties of covalent conjugates of total histone and kanamycin].
A complex containing total histone and antibiotic kanamycin was produced under optimal conditions using glutaric aldehyde. The obtained water-soluble covalently bound conjugates of these substances were identified by means of enzyme labelled immunoassay and their molecular mass estimated. The validity of new class of highly effective drugs, which may be produced basing on the principles studied, was substantiated considering that histones exhibit the transport properties and are able to augment hematoencephalic barrier permeability.
Matiushichev
V B
VB
Goriukhina
O A
OA
Nemtsova
N N
NN
D000818:Animals; D001812:Blood-Brain Barrier; D002417:Cattle; D004591:Electrophoresis, Polyacrylamide Gel; D006657:Histones / Q000378:metabolism*; D007612:Kanamycin / Q000378:metabolism*; D008970:Molecular Weight
D006657:Histones; D007612:Kanamycin
Poluchenie i nekotorye sovĭstva kovalentnykh kon''iugatov summarnogo gistona s kanamitsinom.