title: Implications of gynaecological abnormalities in pre-selection criteria for cervical screening: preliminary evaluation of 3602 subjects in south India.
abstract: Early detection and eradication of cervical cancer and its precursor lesions through organized mass cytological screening programmes have recently gained considerable attention in developing countries. Strategies for both cost saving and effective implementation are however required for mass cervical screening in developing countries. In an early cancer detection programme conducted in South India, we analysed cytological abnormalities in 3602 women and correlated the results with other factors, including age, gynaecological complaints, number of years of married life and parity to see if pre-selection for cytologic screening was possible. Only lower grades of dysplasia were found in asymptomatic women below the age of 40 years. In asymptomatic women, malignancy and higher grades of dysplasia were confined to women with a clinically abnormal cervix only. Univariate analysis also revealed that subjects with a parity of more than 3 and a married life of more than 20 years had a significantly higher number of cytological abnormalities. However, on a multivariate analysis the increased number of marital years was not found to be an independent variable. These results suggest that asymptomatic women below the age of 40 years with a married life of less than 20 years and parity below 3, may be excluded from screening campaigns, and that pre-selection for cytologic screening is possible by introducing a programme of clinical and speculum examination of the cervix.
authors.affiliation: Regional Cancer Centre, Thiruvananthapuram, Kerala State, India.
authors.forename: K
authors.initials: K
authors.lastname: Sujathan
authors.forename: S
authors.initials: S
authors.lastname: Kannan
authors.forename: K R
authors.initials: KR
authors.lastname: Pillai
authors.forename: A
authors.initials: A
authors.lastname: Mathew
authors.forename: M
authors.initials: M
authors.lastname: Joseph
authors.forename: B
authors.initials: B
authors.lastname: Symalakumari
authors.forename: M K
authors.initials: MK
authors.lastname: Nair
mesh_terms: D000328:Adult; D000367:Age Factors; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007194:India; D017533:Marital Status; D008403:Mass Screening; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010298:Parity; D018579:Patient Selection; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000517:prevention & control; D014626:Vaginal Smears / Q000706:statistics & numerical data*