title: Antiallergic dimeric prenylbenzoquinones from Ehretia microphylla.
abstract: The ethyl acetate-soluble portion of the MeOH extract of Ehretia microphylla showed inhibitory activity on exocytosis in antigen-stimulated rat basophils. The bioassay-guided separation of this fraction afforded five biologically active compounds. By means of chemical and spectroscopic methods, the structures of these compounds, which include microphyllone, a unique dimeric prenylbenzoquinone, and its congeners, were elucidated.
authors.affiliation: Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamamura
authors.forename: L R
authors.initials: LR
authors.lastname: Simpol
authors.forename: K
authors.initials: K
authors.lastname: Ozawa
authors.forename: K
authors.initials: K
authors.lastname: Ohtani
authors.forename: H
authors.initials: H
authors.lastname: Otsuka
authors.forename: R
authors.initials: R
authors.lastname: Kasai
authors.forename: K
authors.initials: K
authors.lastname: Yamasaki
authors.forename: W G
authors.initials: WG
authors.lastname: Padolina
mesh_terms: D000485:Allergens; D000818:Animals; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005089:Exocytosis / Q000187:drug effects; D006633:Histamine Antagonists / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010679:Philippines; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000485:Allergens; D016227:Benzoquinones; D006633:Histamine Antagonists