Dynamical analysis of neuromuscular transmission jitter.
Utilizing prolonged axonal stimulation single fiber EMG, neuromuscular transmission becomes a time-series of interpotential intervals (IPIs). In this form, the underlying processes of neuromuscular transmission can be studied using standard numerical techniques to determine whether these processes can be described by a simple mathematical model. In particular, neuromuscular transmission jitter can be examined in this way. In this article, we attempt to determine whether healthy jitter is noise or deterministic chaos. The presence of deterministic chaos was assessed by analysis of the IPI time-series using visual inspection of both phase-space plots and their principal component dimensions, and using the Grassberger-Procaccia algorithm to determine the correlation dimension of the time-series dynamics. These graphical and mathematical techniques provided little evidence for the existence of deterministic chaos. Linear autoregression time-series prediction also failed to account for the variability of the data and IPI histograms exhibited simple gaussian distributions. These results suggest normal neuromuscular transmission jitter is the result of intrinsic noise.
Gilchrist
J M
JM
Department of Clinical Neuroscience, Brown University School of Medicine, Providence, Rhode Island, USA.
Perrone
M
M
Ross
J
J
D000200:Action Potentials; D000465:Algorithms; D001369:Axons / Q000502:physiology*; D004558:Electric Stimulation; D004576:Electromyography; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation* / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D012044:Regression Analysis; D009435:Synaptic Transmission; D013997:Time Factors