title: Successful liver treatment of a juvenile granulosa cell tumor in a 4-year-old child by regional deep hyperthermia, systemic chemotherapy, and irradiation.
abstract: Juvenile granulosa cell tumors (JGCT) of the ovary are rare in children and adolescents. About 90% are diagnosed in early-stage FIGO I with favorable prognosis. More advanced stages (FIGO II-IV) have a poor clinical outcome and chemotherapy alone cannot avoid tumor progression. Regional deep hyperthermia (RHT) induced by microwave technique has been established as an additional modality for treatment of different tumors. However, in cases with liver involvement there are technical problems which have not yet been solved. We report on a 4-year-old child who suffered from diffuse liver metastases 10 months after JGCT of the left ovary. After chemotherapy including ifosfamide, etoposide, and carboplatin in combination with RHT and consolidation radiotherapy, the patient has been in complete remission for 1 year of follow-up. This Case Report indicates the feasibility of combining surgery, chemotherapy, hyperthermia, and radiation therapy (which can also be an effective treatment modality for advanced granulosa cell tumor) for the treatment of liver metastases of JGCT, but does not allow comparisons of these treatments.
authors.affiliation: Department of Pediatrics, Heinrich-Heine University, Düsseldorf, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Wessalowski
authors.forename: H J
authors.initials: HJ
authors.lastname: Spaar
authors.forename: H
authors.initials: H
authors.lastname: Pape
authors.forename: R
authors.initials: R
authors.lastname: Willers
authors.forename: D
authors.initials: D
authors.lastname: Harms
authors.forename: U
authors.initials: U
authors.lastname: Göbel
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006106:Granulosa Cell Tumor / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects; D007069:Ifosfamide / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D010053:Ovary / Q000601:surgery; D012074:Remission Induction; D013696:Temperature; D000637:Transaminases / Q000378:metabolism
chemical_list: D005047:Etoposide; D016190:Carboplatin; D000637:Transaminases; D007069:Ifosfamide