[Levels of endothelin-1 in bronchoalveolar lavage fluid of patients with bronchial asthma].
To evaluate the role of endothelin in the pathogenesis of bronchial asthma endothelin-1 levels were studied in the bronchoalveolar lavage fluid of symptomatic (n = 7) and asymptomatic (n = 10) asthmatic patients and healthy volunteers (n = 6). In all patients BAL fluid levels of endothelin-1 was assessed by RIA, total protein concentration by Lowry method. Patients with symptomatic asthma had increased amount of ET-1 in BAL fluid than asymptomatic asthmatics and control group.


CONCLUSIONS
1. Presence of endothelin in BAL fluid indicate that this peptide is involved in the pathogenesis of bronchial asthma. 2. Endothelin-1 BAL fluid levels may correlate with the severity of bronchial asthma.
Gawlik
R
R
Katedry i Kliniki Chorób Wewnetrznych i Alergologii, Akademii Medycznej w Katowicach.
Pluskiewicz
W
W
Ziora
D
D
D000328:Adult; D001249:Asthma / Q000209:etiology / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D016232:Endothelins / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D016232:Endothelins
Zawartość endoteliny-1 w popłuczynach pecherzykowo-oskrzelikowych chorych na astme oskrzelowa.