title: Hypersensitivity hepatitis due to pyrazinamide.
abstract: Pyrazinamide hepatotoxicity is considered secondary to a direct and dose-related toxic effect. At currently used doses, pyrazinamide provides effective short-term treatment and is free from serious side effects. We report a case of pyrazinamide-induced hepatitis for which the rechallenge data strongly suggest a hypersensitivity mechanism.
authors.affiliation: Department of Infectious Diseases, Hospital de Bellvitge, University of Barcelona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Corbella
authors.forename: M
authors.initials: M
authors.lastname: Vadillo
authors.forename: C
authors.initials: C
authors.lastname: Cabellos
authors.forename: P
authors.initials: P
authors.lastname: Fernandez-Viladrich
authors.forename: G
authors.initials: G
authors.lastname: Rufi
mesh_terms: D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008875:Middle Aged; D011718:Pyrazinamide / Q000009:adverse effects*
chemical_list: D011718:Pyrazinamide