Anticancer effects of adriamycin-loaded hydroxyapatite implants determined in a Swarm rat chondrosarcoma model.
We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.
Yamamura
K
K
Department of Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Iwata
H
H
Osada
T
T
Yotsuyanagi
T
T
Nabeshima
T
T
D000818:Animals; D001859:Bone Neoplasms / Q000188:drug therapy*; D002813:Chondrosarcoma / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D017886:Durapatite / Q000737:chemistry / Q000378:metabolism; D005260:Female; D008017:Life Expectancy; D008297:Male; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley
D003692:Delayed-Action Preparations; D004317:Doxorubicin; D017886:Durapatite