Influence of acute arterial hypertension on blood-brain barrier permeability in streptozocin-induced diabetic rats.
The effect of acute arterial hypertension on blood-brain barrier (BBB) permeability was studied in streptozocin-induced diabetic rats using Evans blue as a barrier tracer. Four groups of rats were studied: Group 1, normotensive normoglycemia; Group II, normotensive+diabetes mellitus; Group III, arterial hypertension+diabetes mellitus; Group IV, arterial-hypertension+normoglycemia. During adrenaline-induced acute arterial hypertension the mean arterial blood pressure increased in both non-diabetic and diabetic animals. Changes in BBB permeability were observed in 52% of the non-diabetic rats, and in 72% of the diabetic rats after adrenaline-induced acute arterial hypertension. Mean levels of Evans blue in the whole brain were found to be 0.63 +/- 0.1 mg% in non-diabetic and 0.90 +/- 0.2 mg% in diabetic rats. The difference between the non-diabetic and the diabetic rats was found to be statistically significant (P < 0.01). From these results it was suggested that the extravasation of Evans blue albumin is more pronounced in the brains of diabetic rats in comparison with non-diabetic rats after adrenaline-induced acute hypertension, which is indicative of changes in BBB permeability due to diabetes mellitus.
Oztaş
B
B
Department of Physiology, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
Küçük
M
M
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D005070:Evans Blue; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D005070:Evans Blue; D004837:Epinephrine