title: Comparison of two shampoos for treatment of Malassezia pachydermatis-associated seborrhoeic dermatitis in basset hounds.
abstract: A randomised-double-blind parallel study compared the clinical and antimicrobial efficacies of a miconazole-chlorhexidine shampoo with a selenium sulphide shampoo for the treatment of seborrhoeic dermatitis associated with Malassezia pachydermatis in 33 basset hounds. All 16 miconazole-chlorhexidine treated hounds and 11 of 17 selenium sulphide treated hounds improved when shampooed at three-day intervals for three weeks. The miconazole-chlorhexidine treated hounds showed significantly greater reductions in pruritus (P < 0.01), erythema (P < 0.001), exudation (P < 0.01) and overall severity (P < 0.001), and in counts of M pachydermatis (P < 0.001), total bacteria (P < 0.001) and coagulase-positive staphylococci (P < 0.001), when compared to the selenium sulphide treated group. Improvements in scaling and coat condition did not vary significantly between the two groups. These results indicate that seborrhoeic dermatitis in basset hounds is often associated with elevated cutaneous populations of M pachydermatis and bacteria, and that the miconazole-chlorhexidine shampoo is more effective than the selenium sulphide product for the treatment for this disease.
authors.affiliation: Department of Small Animal Medicine and Surgery, Royal Veterinary College, Hatfield, Hertfordshire.
authors.forename: R
authors.initials: R
authors.lastname: Bond
authors.forename: J F
authors.initials: JF
authors.lastname: Rose
authors.forename: J W
authors.initials: JW
authors.lastname: Ellis
authors.forename: D H
authors.initials: DH
authors.lastname: Lloyd
mesh_terms: D000818:Animals; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use*; D012628:Dermatitis, Seborrheic / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D003881:Dermatomycoses / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D008290:Malassezia / Q000187:drug effects* / Q000302:isolation & purification; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D018036:Selenium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000382:microbiology; D012915:Soaps; D016896:Treatment Outcome
chemical_list: D018036:Selenium Compounds; D012915:Soaps; D008825:Miconazole; D002710:Chlorhexidine; C025698:selenium disulfide