[The effect of substances produced by a strain of Streptococcus sp. Thom-1606 on phagocytic activity].
Among the substances produced by Streptococcus sp. strain TOM-1606 two fractions having the opposite influence on the phagocytic activity of peritoneal macrophages of white mice were detected. The fraction corresponding to peptides with a molecular weight not exceeding 10 kD activated natural phagocytosis. As shown in our earlier works, this fraction also had the maximum antimicrobial activity. The fraction with a molecular weight of 70-100 kD inhibited natural phagocytosis, acting as an immunosuppressive agent.
Golshmid
V K
VK
Landsman
N M
NM
Savranskaia
S Ia
SIa
Zakharova
N E
NE
D000276:Adjuvants, Immunologic / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001430:Bacteriocins; D004352:Drug Resistance, Microbial; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D010587:Phagocytosis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D007166:Immunosuppressive Agents; C026129:tomicide
Vliianie substantsiĭ, produtsiruemykh shtammom Streptococcus sp. TOM-1606, na fagotsitarnuiu aktivnost'.