Molecular chaperones and the biosynthesis of antigen receptors.
Oligomeric antigen receptors must fold and assemble in the endoplasmic reticulum (ER) before they can be expressed on the surface of lymphocytes. It is increasingly evident that these processes are facilitated by molecular chaperones. Here, Jeffrey Melnick and Yair Argon review the known ER chaperones, summarize their roles in the maturation of antigen receptors, and discuss how they may affect lymphocyte differentiation and function.
Melnick
J
J
Dept of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Argon
Y
Y
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D018832:Molecular Chaperones / Q000276:immunology / Q000378:metabolism*; D017510:Protein Folding; D011946:Receptors, Antigen / Q000096:biosynthesis* / Q000276:immunology
D018832:Molecular Chaperones; D011946:Receptors, Antigen