title: MR imaging of intrahepatic cholangiocarcinoma.
abstract: BACKGROUND
  The purpose of this study was to determine the magnetic resonance (MR) features of intrahepatic cholangiocarcinoma.
  
  
  METHODS
  MR imaging studies of seven cases of pathologically proven intrahepatic cholangiocarcinoma were retrospectively reviewed.
  
  
  RESULTS
  On MR images the tumors presented as a single mass (N = 5) or multiple nodules (N = 2), as well-delineated (N = 5) or ill-defined (N = 2), and as nonencapsulated (N = 7). Mean tumor diameter ranged from 6-14 cm (mean, 10 cm). On T1-weighted (TR/TE = 400-600/10-17 msec) images, the tumors were hypointense compared to the liver. The five tumors studied with dynamic MR imaging showed progressive centripetal filling-in after intravenous administration of a gadolinium chelate. On T2-weighted (TR/TE = 2000-2500/80-100 msec) images, all tumors were hyperintense compared to the liver; five were markedly hyperintense and two moderately hyperintense. Vascular encasement, bile duct dilatation within the tumor, and central scar were depicted on MR images in four, three, and two tumors respectively.
  
  
  CONCLUSIONS
  The typical MR appearance of intrahepatic cholangiocarcinoma is a large well-delineated nonencapsulated tumor associated with intrahepatic venous encasement.
authors.affiliation: Department of Radiology, Johns Hopkins Hospital, Baltimore, MD 21287-2180, USA.
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.forename: D A
authors.initials: DA
authors.lastname: Bluemke
authors.forename: A
authors.initials: A
authors.lastname: Sibert
authors.forename: J P
authors.initials: JP
authors.lastname: Laissy
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D005682:Gadolinium