title: Child and adolescent (juvenile onset) schizophrenia. A case control study of premorbid developmental impairments.
abstract: BACKGROUND
  The study tests the hypothesis that juvenile-onset schizophrenia is associated with premorbid developmental impairments. It was predicted that the pattern of developmental impairments would vary with age of onset and with gender.
  
  
  METHODS
  A case-control design was used to examine developmental impairments in 61 consecutive juvenile-onset (age 7-17) referrals with ICD-9 schizophrenia; 61 non-psychotic psychiatric controls were matched on age and gender. Cases and controls were divided into childhood-onset (age 7-13) and adolescent-onset (age 14-17).
  
  
  RESULTS
  The schizophrenic cases had a significantly higher risk of premorbid social (chi 2 = 9.1, P < 0.005), motor (chi 2 = 9.1, P < 0.005) and language impairments (chi 2 = 10.1, P < 0.005). Specific impairments of language production and comprehension were associated with childhood-onset schizophrenia and were independent of gender.
  
  
  CONCLUSIONS
  Juvenile-onset schizophrenia is associated with a range of developmental antecedents. There may be a specific link between cases with a very early onset and an impairment in the processes underlying the development of language.
authors.affiliation: Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London.
authors.forename: C
authors.initials: C
authors.lastname: Hollis
mesh_terms: D017668:Age of Onset; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000209:etiology; D008297:Male; D011569:Psychiatric Status Rating Scales; D011596:Psychomotor Disorders / Q000209:etiology; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012737:Sex Factors