3-(3-Hydroxyphenyl)-N-(1-propyl)piperidine elicits convulsant effects in mice.
1. The behaviour and EEG effects of the dopamine and sigma (sigma) ligands (+) 3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)3-PPP) were studied in mice. 2. (+) 3-PPP dose-dependently (60-100 mg/kg i.p.) produced behavioural and electrical tonic-clonic seizures. 3. The incidence of the tonic seizures elicited by 100 mg/kg of the drug was significantly (P < 0.05) prevented by spiperone (0.5 mg/kg i.p.) and haloperidol (0.5 mg/kg i.p.). 4. The results show an influence on the behavioural and electrical threshold of convulsions by (+) 3-PPP depending on a prevalent interference on dopamine receptors.
Pieretti
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Pharmacology Department, Istituto Superiore di Sanità, Rome, Italy.
Di Giannuario
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A
Sagratella
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D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003292:Convulsants / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D008297:Male; D051379:Mice; D010880:Piperidines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D017480:Receptors, sigma / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced / Q000523:psychology; D013237:Stereoisomerism
D014150:Antipsychotic Agents; D003292:Convulsants; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D010880:Piperidines; D017480:Receptors, sigma; C026539:preclamol