[The Amben regulation of the intestinal microflora and macrophage functional activity in an experiment].
The possibility of the correction of intestinal microflora disorders and the functional activity of macrophages in dysbiosis, caused by the intragastric administration of ampiox, with the use of amben (PAMBA), an inhibitor of proteolytic enzymes, was studied. Quantitative and qualitative changes in the main representatives of automicroflora, the functional activity of macrophages in the phagocytosis of 51Cr-labeled sheep red blood cells, the intensity of protein synthesis, the content of cathepsin D, acidic phosphatase and nitro blue tetrazolium activity were determined. The combined administration of ampiox and amben normalized quantitative and qualitative ratios of the main representatives of intestinal microflora, as well as the characteristics of macrophage functional activity, studied in this investigation. The administration of amben to intact animals was found to stimulate bifido- and lactoflora.
Gorskaia
E M
EM
Zaĭtseva
L G
LG
Bondarenko
V M
VM
Vasil'eva
E I
EI
Kornienko
O Iu
OIu
Mazankova
L N
LN
D010129:4-Aminobenzoic Acid / Q000494:pharmacology / Q000627:therapeutic use; D000667:Ampicillin / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D001424:Bacterial Infections / Q000139:chemically induced / Q000188:drug therapy / Q000382:microbiology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use; D007410:Intestinal Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000382:microbiology; D007422:Intestines / Q000187:drug effects* / Q000382:microbiology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D008297:Male; D010068:Oxacillin / Q000009:adverse effects / Q000627:therapeutic use; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014361:Trypsin Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D062366:para-Aminobenzoates
D014361:Trypsin Inhibitors; D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D000667:Ampicillin; C000307:broadcillin; D010129:4-Aminobenzoic Acid; D010068:Oxacillin
Reguliatsiia ambenom kishechnoĭ mikroflory i funktsional'noĭ aktivnosti makrofagov v éksperimente.