The evaluation of hepatoprotective effects of Taiwan folk medicine 'teng-khia-u'.
'Teng-khia-u' is a folk medicine of Taiwan, derived from the entire plants of Elephantopus scaber L., E. mollis H.B.K. and Pseudoelephantopus spicatus (Juss.) Rohr. The hepatoprotective effects of water extracts of these three plants against beta-D-galactosamine (D-GalN)- and acetaminophen (APAP)-induced acute hepatic damage were determined in rats. The results indicated that the serum glutamate-oxalate-transaminase (sGOT) and the serum glutamate-pyruvate-transaminase (sGPT) levels caused by D-GalN and APAP decreased after treatment with crude extracts of 'teng-khia-u' (P < 0.005). The pathological changes of hepatic lesions, caused by D-GalN and APAP, improved following treatment with the drug extracts mentioned above.
Lin
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Graduate Institute of Natural Products of Kaohsiung Medical College, Taiwan, ROC.
Tsai
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CC
Yen
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D000082:Acetaminophen / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002455:Cell Division / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D005688:Galactosamine / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy* / Q000517:prevention & control; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013624:Taiwan
D010936:Plant Extracts; D000082:Acetaminophen; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase