title: Change in cerebral blood flow velocity with onset of EEG silence during inhalation anesthesia in humans: evidence of flow-metabolism coupling?
abstract: In eight subjects anesthetized with moderate to high doses of inhalation anesthetics (isoflurane or desflurane) during normocapnia, the onset of electrical silence in EEG was associated with a sudden reduction of blood flow velocity monitored from the middle cerebral artery. The magnitude of this reduction was 38 +/- 11% (mean +/- SD; range 24-44%). The change in EEG always preceded the change in flow velocity by 5-7 s. These observations suggest that some flow-metabolism coupling mechanism is preserved during inhalation anesthesia in humans.
authors.affiliation: Department of Anesthesiology, University of Washington School of Medicine, Seattle, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Lam
authors.forename: B F
authors.initials: BF
authors.lastname: Matta
authors.forename: T S
authors.initials: TS
authors.lastname: Mayberg
authors.forename: S
authors.initials: S
authors.lastname: Strebel
mesh_terms: D000293:Adolescent; D000328:Adult; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D000077335:Desflurane; D004569:Electroencephalography; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane