title: Macrophage colony-stimulating factor-producing malignant histiocytosis.
abstract: We describe a patient with malignant histiocytosis who had a prominent neutrophilia uncommonly observed in this disease. Serum concentration of macrophage colony-stimulating factor (M-CSF) was markedly elevated, and correlated with clinical symptoms and neutrophil counts during clinical course. Moreover, M-CSF was detected in the cytoplasm of malignant histiocytes of the lymph node and bone marrow by immunohistochemical staining. These results indicate that the neutrophilia observed in this patient was caused by M-CSF produced by the malignant histiocytes.
authors.affiliation: First Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ozaki
authors.forename: T
authors.initials: T
authors.lastname: Matsushita
authors.forename: M
authors.initials: M
authors.lastname: Ide
authors.forename: K
authors.initials: K
authors.lastname: Ozaki
authors.forename: T
authors.initials: T
authors.lastname: Sano
authors.forename: M
authors.initials: M
authors.lastname: Kosaka
authors.forename: S
authors.initials: S
authors.lastname: Saito
mesh_terms: D000328:Adult; D005260:Female; D015614:Histiocytosis / Q000150:complications / Q000378:metabolism*; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D009503:Neutropenia / Q000150:complications / Q000378:metabolism
chemical_list: D016173:Macrophage Colony-Stimulating Factor