(+/-)-Gelliusines A and B, two diastereomeric brominated tris-indole alkaloids from a deep water new caledonian marine sponge (Gellius or Orina sp.).
Two new diastereomeric brominated tris-indole alkaloids occurring as enantiomeric pairs, (+/-)-gelliusines A [1] and B [2], have been isolated from a deep water New Caledonian sponge (Gellius or Orina sp.), whose crude extract exhibited cytotoxicity against KB cells. Their structures were elucidated by spectroscopic methods including one- and two-dimensional nmr spectroscopy. The major compound, (+/-) gelliusine A [1], which showed very weak cytotoxicity, proved to be active at the serotonin receptor.
Bifulco
G
G
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
Bruno
I
I
Minale
L
L
Riccio
R
R
Calignano
A
A
Debitus
C
C
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D007211:Indoles; D017366:Serotonin Receptor Agonists; C091091:gelliusine A