Protein level in testes, kidneys and liver after AET or MEA treatment of mice.
The adult male Swiss mice were treated intraperitoneally with AET (2-aminoethylisothiouronium Br.HBr) or MEA (cysteamine HCl), in a toxic dose of 400 mg/kg body weight. The measurements of the protein content in crude homogenates of testes, kidneys and liver were done every fourth hour throughout a 24-hour period. Treatment of mice with AET and MEA resulted in different patterns of temporal changes in the protein content in testes, kidneys and liver expressed in mg per 1 g of fresh tissue and per the whole organ weight. The extent and timing of the alterations in the protein level appeared to depend on the particular organ chosen and the thiol agent applied.
Mazur
L
L
Department of Animal Physiology, Jagiellonian University, Cracow, Poland.
Bobik
R
R
Manowska
J
J
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003543:Cysteamine / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000187:drug effects* / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism; D000338:beta-Aminoethyl Isothiourea / Q000633:toxicity*
D011506:Proteins; D000338:beta-Aminoethyl Isothiourea; D003543:Cysteamine