title: Fetal hepatosplenomegaly associated with transient myeloproliferative disorder in trisomy 21.
abstract: The in utero diagnosis of fetal myeloproliferative disease was made by cordocentesis following the ultrasound appearance of fetal hepatosplenomegaly and mild hydrops. The 2 fetuses reported both had leukocyte counts greater than 75,000/mm3 with a predominance of blast forms. In both cases the karyotype revealed trisomy 21.
authors.affiliation: Department of Obstetrics and Gynecology, Jefferson Medical College, Philadelphia, Pa., USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Macones
authors.forename: A
authors.initials: A
authors.lastname: Johnson
authors.forename: D
authors.initials: D
authors.lastname: Tilley
authors.forename: R
authors.initials: R
authors.lastname: Wade
authors.forename: R
authors.initials: R
authors.lastname: Wapner
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005315:Fetal Diseases / Q000175:diagnosis*; D006529:Hepatomegaly / Q000150:complications*; D006801:Humans; D007938:Leukemia / Q000151:congenital; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000175:diagnosis; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013163:Splenomegaly / Q000150:complications