title: Incorporation of thioamide linkages into a growing peptide under SPPS conditions improved by salt effects.
abstract: Amino acid methyl dithioesters may be coupled in the presence of DMAP and salts to a growing peptide chain on a polymeric resin with high coupling yields and low racemization.
authors.affiliation: Institute of Natural Product Chemistry, CNRS, Gif sur Yvette, France.
authors.forename: H T
authors.initials: HT
authors.lastname: Le
authors.forename: M
authors.initials: M
authors.lastname: Mayer
authors.forename: S
authors.initials: S
authors.lastname: Thoret
authors.forename: R
authors.initials: R
authors.lastname: Michelot
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives; D000595:Amino Acid Sequence; D001559:Benzhydryl Compounds; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D012117:Resins, Synthetic; D012492:Salts / Q000494:pharmacology; D013854:Thioamides / Q000737:chemistry*
chemical_list: C030545:4-methylbenzhydrylamine resin; D001559:Benzhydryl Compounds; D004952:Esters; D009842:Oligopeptides; D012117:Resins, Synthetic; D012492:Salts; D013854:Thioamides; D015761:4-Aminopyridine; C003885:4-dimethylaminopyridine