Altered lipid metabolism in the failing heart of cardiomyopathic hamsters (UM-X7.1).
The lipid composition of different anatomic regions of 150 day-old UM-X7.1 cardiomyopathic hamster and age-matched controls (Syrian golden hamsters) was examined. Cardiomyopathic hamsters exhibit a phospholipid to protein ratio higher than healthy animals in atria, whereas the contrary is true in the other anatomic regions examined. In all tissues the cholesterol to phospholipid ratio is higher in cardiomyopathic hamster than in controls. Healthy and UM-X7.1 hamsters differ substantially as far as the percent distribution of fatty acids in total lipids is concerned, the lipids from cardiomyopathic animals accumulating fatty acids of the omega-6 series and being relatively poor in monoenoic fatty acids. The different fatty acid composition of heart lipids appears to be a consequence of a generalized disturbance of the lipid metabolism in cardiomyopathic hamsters during congestive heart failure.
Vecchini
A
A
Institute of Biochemistry and Medical Chemistry, University of Perugia, Italy.
Binaglia
L
L
Di Nardo
P
P
Minieri
M
M
Panagia
V
V
Dhalla
N S
NS
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D006224:Cricetinae; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism; D008647:Mesocricetus; D009206:Myocardium / Q000378:metabolism; D010743:Phospholipids / Q000097:blood / Q000378:metabolism
D005227:Fatty Acids; D010743:Phospholipids; D002784:Cholesterol