Isolation, characterization and structure of a new allenic polyine antibiotic produced by fungus LL-07F275.
Antibiotic 07F275 (1), produced by submerged fermentations of fungal culture LL-07F275, was isolated and characterized despite its inherent instability. Its UV spectrum was identical with that of nemotin, a member of the allenic polyacetylene family, but a molecular weight of 218 daltons indicated a new compound. Structure 1 was determined on the basis of spectroscopic evidence, particularly NMR. Since 1 is a thirteen carbon-containing allenic diyne, it is closely related to mycomycin.
Schlingmann
G
G
American Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, N.Y. USA 10965, USA.
Milne
L
L
Pearce
C J
CJ
Borders
D B
DB
Greenstein
M
M
Maiese
W M
WM
Carter
G T
GT
D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000378:metabolism; D008826:Microbial Sensitivity Tests
D000480:Alkynes; D000900:Anti-Bacterial Agents; C094348:antibiotic 07F275