Pharmacokinetics of cadmium following intravenous and oral administration to non-lactating ewes.
In a preliminary study, ewes received daily oral cadmium chloride administrations and cadmium concentration was measured in blood and tissues. A pharmacokinetic analysis of cadmium disposition was then carried out in ewes administered cadmium chloride iv and, 21 months later, orally in the same ewes. Pharmacokinetic parameters were analysed using a 3-compartment open model. The systemic availability was 0.15-0.5%, the half-life of elimination was 100-150 d, the blood clearance was 0.12-0.16 l.kg-1.d-1 and the steady-state volume of distribution was 17-35 l/kg. Following iv administration cadmium was found in tissues about 2 years later.
Houpert
P
P
Ecole nationale vétérinaire d'Alfort, service de pharmacie et toxicologie, Maisons-Alfort, France.
Mehennaoui
S
S
Joseph-Enriquez
B
B
Federspiel
B
B
Milhaud
G
G
D000284:Administration, Oral; D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004032:Diet; D005260:Female; D007275:Injections, Intravenous; D012756:Sheep / Q000097:blood / Q000378:metabolism*; D013054:Spectrophotometry, Atomic / Q000662:veterinary; D014018:Tissue Distribution
D002104:Cadmium