Cell surface characteristics of Helicobacter pylori.
Helicobacter pylori is an important gastroduodenal pathogen of humans. Immunological and structural studies have been performed on the phospholipids, lipopolysaccharides (LPS) and some surface proteins of H. pylori strains. H. pylori LPS has, in general, low immunological activity and this property may aid the survival of this chronic infection. Nevertheless, H. pylori LPS has been found to influence the quality of gastric mucin and to stimulate pepsinogen secretion, thereby contributing to gastric disease. A number of putative adhesins of the bacterium have been described. This multiplicity of adhesins may reflect that H. pylori adherence is a multi-step process involving different interactions, and that different adhesins may mediate adherence to various sites in gastric tissue.
Moran
A P
AP
Department of Microbiology, University College, Galway, Ireland.
D018829:Adhesins, Bacterial / Q000737:chemistry / Q000502:physiology; D000818:Animals; D016667:Bacterial Capsules / Q000502:physiology; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000502:physiology; D002240:Carbohydrate Sequence; D002473:Cell Wall / Q000737:chemistry / Q000502:physiology; D006360:Heat-Shock Proteins / Q000737:chemistry; D016480:Helicobacter pylori / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry* / Q000276:immunology*; D008969:Molecular Sequence Data; D018272:Porins / Q000737:chemistry / Q000276:immunology; D051381:Rats
D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D006360:Heat-Shock Proteins; D008070:Lipopolysaccharides; D018272:Porins