title: [Personal experience with administration of Zinacef in the form of a "protected coagulum" in patients after heart surgery].
abstract: Antibiotic prophylaxis in the form of a so-called protected coagulum is an important part of prevention of postoperative infections in cardiosurgery. The selection of a suitable antibiotic depends on many factors--its effectiveness against the most frequent pathogens, the tissue penetration, undesirable effects. The authors compared two groups of patients operated on account of IHD using prophylaxis with cefalotine (491 patients) and cefuroxime (241 patients). The groups are comparable as to baseline parameters. In the cefuroxime-treated group was a significantly lower incidence of infections of the surgical wound (12.6 % vs. 5.8 %). The number of serious infectious complications (mediastinitis, osteomyelitis) and the incidence of other infections did not differ in the two groups.
authors.affiliation: Klinika kardiovaskulární a transplantacní chirurgie IKEM, Praha.
authors.forename: V
authors.initials: V
authors.lastname: Rohn
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D002444:Cefuroxime / Q000008:administration & dosage*; D002512:Cephalothin / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D011292:Premedication
chemical_list: D002444:Cefuroxime; D002512:Cephalothin
vernacular_title: Nase zkusenosti s podáváním Zinacefu formou "chránĕného koagula " u nemocných po operaci srdce.