Localization of apoptosis (programmed cell death) in mice by administration of lipopolysaccharide.
Localization of apoptotic cells by administration of lipopolysaccharide into mice was studied by using the in situ specific labeling of fragmented DNA. This method clearly stained the nuclei of thymocytes at the cortex of the thymus. The nuclei of cells in the bone marrow and in the spleen were also positively stained. It was suggested that the cortex in the thymus is where the LPS-induced programmed cell death occurs.
Zhang
X M
XM
Department of Microbiology, Aichi Medical University, Japan.
Morikawa
A
A
Takahashi
K
K
Jiang
G Z
GZ
Kato
Y
Y
Sugiyama
T
T
Kawai
M
M
Fukada
M
M
Yokochi
T
T
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D001854:Bone Marrow Cells; D004247:DNA / Q000032:analysis; D004249:DNA Damage; D004926:Escherichia coli; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology*
D008070:Lipopolysaccharides; D004247:DNA