[Olfactory neuroblastoma: a histopathological ultrastructural and immunohistochemical study of 11 cases].
Eleven cases of olfactory neuroblastoma (ONB) were studied histopathologically, ultrastructurally and immunohistochemically. Light microscopical examination showed the tumor cell nests separated by fibrous connective tissue (present in 10/11 ONB), Homer-Wright rosette and/or Flexner rosette (9/11 ONB) and acidophilic fibrillary background (8/11 ONB). Ultrastructurally, there were neurosecretory granules (2/2 ONB) and neurofibrils (1/2 ONB) in cytoplasm of tumor cells. A panel of antibodies were used to characterize the immunohistochemical staining profile of ONB. The following results were obtained for the 11 neoplasms that were immunostained: NSE 11/11 (+), S-100 3/11 (+), Vimentin 4/11 (+), Keratin 1/11 (+) and NF, EMA, CEA, LCA all negative respectively. The significance of the morphological and immunohistochemical features of ONB in diagnosis and differential diagnosis were discussed.
Yang
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Department of Pathology, Human Medical University, Changsha.
Zeng
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D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018304:Esthesioneuroblastoma, Olfactory / Q000737:chemistry / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000648:ultrastructure*; D009669:Nose Neoplasms / Q000737:chemistry / Q000648:ultrastructure*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase