title: Parameterized complexity analysis in computational biology.
abstract: Many computational problems in biology involve parameters for which a small range of values cover important applications. We argue that for many problems in this setting, parameterized computational complexity rather than NP-completeness is the appropriate tool for studying apparent intractability. At issue in the theory of parameterized complexity is whether a problem can be solved in time O(n alpha) for each fixed parameter value, where alpha is a constant independent of the parameter. In addition to surveying this complexity framework, we describe a new result for the Longest Common Subsequence problem. In particular, we show that the problem is hard for W[t] for all t when parameterized by the number of strings and the size of the alphabet. Lower bounds on the complexity of this basic combinatorial problem imply lower bounds on more general sequence alignment and consensus discovery problems. We also describe a number of open problems pertaining to the parameterized complexity of problems in computational biology where small parameter values are important.
authors.affiliation: Computer Science Department, Utrecht University, The Netherlands.
authors.forename: H L
authors.initials: HL
authors.lastname: Bodlaender
authors.forename: R G
authors.initials: RG
authors.lastname: Downey
authors.forename: M R
authors.initials: MR
authors.lastname: Fellows
authors.forename: M T
authors.initials: MT
authors.lastname: Hallett
authors.forename: H T
authors.initials: HT
authors.lastname: Wareham
mesh_terms: D000465:Algorithms; D001699:Biometry / Q000379:methods*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005069:Evaluation Studies as Topic; D015233:Models, Statistical; D009690:Nucleic Acid Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D011506:Proteins; D004247:DNA