title: Correction of anaemia and thrombocytopenia in a case of adult type I osteopetrosis with recombinant human erythropoietin (rHuEPO).
abstract: A case of adult osteopetrosis Type I was diagnosed in a 22-year-old female. She presented for investigation of anaemia with 'myelophthisic' characteristics and extramedullary haemopoiesis which was resistant to haematinics, nandrolone and low-dose corticosteroids. She became progressively transfusion-dependent with gradually worsening thrombocytopenia. She was successfully treated with recombinant erythropoietin. Anaemia as well as thrombocytopenia were corrected. There appeared to be a synergistic action of erythropoietin with steroids.
authors.affiliation: First Department of Internal Medicine,University of Athens School of Medicine, Laikon General Hospital, Greece.
authors.forename: J
authors.initials: J
authors.lastname: Meletis
authors.forename: M
authors.initials: M
authors.lastname: Samarkos
authors.forename: E
authors.initials: E
authors.lastname: Michali
authors.forename: S
authors.initials: S
authors.lastname: Vavourakis
authors.forename: C
authors.initials: C
authors.lastname: Meletis
authors.forename: C
authors.initials: C
authors.lastname: Poziopoulos
authors.forename: N
authors.initials: N
authors.lastname: Stavrogianni
authors.forename: K
authors.initials: K
authors.lastname: Konstantopoulos
authors.forename: G
authors.initials: G
authors.lastname: Vaiopoulos
authors.forename: X
authors.initials: X
authors.lastname: Yataganas
mesh_terms: D000328:Adult; D000740:Anemia / Q000209:etiology / Q000628:therapy*; D001855:Bone Marrow Diseases / Q000150:complications / Q000628:therapy; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010022:Osteopetrosis / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy*
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin