title: 99mTechnetium labelled leucocyte scanning in acute lower abdominal pain: can it reduce the negative appendectomy rate?
abstract: While the incidence of 'negative' appendectomy has long been justified as a necessary evil in the management of acute appendicitis, attempts to improve diagnostic accuracy have met with mixed results. In a prospective study of 34 selected patients who presented with acute lower abdominal pain the potential role of 99mTechnetium labelled leucocyte scanning in the diagnosis of acute appendicitis has been evaluated. Patient management was not based on the result of the nuclear scan. The clinical outcome was correlated with the scan diagnosis. There was one false positive and one false negative scan result with respect to the clinical diagnosis of appendicitis yielding a sensitivity of 90% and a specificity of 96%. 99mTechnetium labelled leucocyte scanning may have an important role in the assessment of selected patients presenting with acute lower abdominal pain.
authors.affiliation: Department of Surgery, Royal Adelaide Hospital, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Moore
authors.forename: D
authors.initials: D
authors.lastname: Bartholomeusz
authors.forename: A
authors.initials: A
authors.lastname: Wycherley
authors.forename: P
authors.initials: P
authors.lastname: Devitt
authors.forename: J
authors.initials: J
authors.lastname: Toouli
authors.forename: P
authors.initials: P
authors.lastname: Drew
mesh_terms: D000006:Abdomen, Acute / Q000000981:diagnostic imaging* / Q000209:etiology; D000293:Adolescent; D000328:Adult; D001062:Appendectomy / Q000706:statistics & numerical data*; D001064:Appendicitis / Q000000981:diagnostic imaging* / Q000601:surgery; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013667:Technetium
chemical_list: D013667:Technetium