Epstein-Barr virus immortalizing genes.
Epstein-Barr virus (EBV) is linked to several types of human cancer and immortalizes human B cells very efficiently; at least six viral genes are required for this. The mechanism by which EBV immortalizes cells is particularly interesting because its immortalization genes are not obvious homologues of those of other DNA tumour viruses.
Farrell
P J
PJ
Ludwig Institute for Cancer Research, St Mary's Hospital Medical School, London, UK.
D001402:B-Lymphocytes / Q000821:virology*; D001483:Base Sequence; D002472:Cell Transformation, Viral / Q000235:genetics*; D005814:Genes, Viral / Q000235:genetics*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data