[The effect of reaferon on the opioid systems of chronically alcoholized rats].
Chronic alcoholic intoxication is followed by a fall in 3H-(D-ala-2,D-leu-5)-enkephalin affinity of mu-opioid receptors with their unchanged concentrations in the rat brain cortex, by reductions in the tissue and plasma levels of beta-endorphine and met-enkephalin. A daily administration of reaferon in a dose of 10,000 IU during two fortnights completely restored both the binding affinity of the receptors and the concentrations of the peptides tested: those of beta-endorphine in the adenohypophysis and plasma and those of metenkephalin in the adrenals and plasma.
Petrichenko
O B
OB
Balashov
A M
AM
Aliab'eva
T N
TN
Panchenko
L F
LF
D000427:Alcohol Deterrents / Q000494:pharmacology / Q000627:therapeutic use*; D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004744:Enkephalin, Methionine / Q000187:drug effects / Q000378:metabolism; D007370:Interferon Type I / Q000494:pharmacology / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008024:Ligands; D008297:Male; D011485:Protein Binding / Q000187:drug effects; D011869:Radioligand Assay; D051381:Rats; D011957:Receptors, Opioid / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D011994:Recombinant Proteins; D001615:beta-Endorphin / Q000187:drug effects / Q000378:metabolism
D000427:Alcohol Deterrents; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008024:Ligands; D011957:Receptors, Opioid; D011994:Recombinant Proteins; D004744:Enkephalin, Methionine; D001615:beta-Endorphin
Vliianie reaferon na opioidnye sistemy khronicheski alkogolizirovannykh krys.