The morphological properties of the blood thrombocytes in bronchial asthma patients before and after thrombocytapheresis.
Morphological characteristics of platelets were assessed electron microscopically in 15 patients with atopic and aspirin bronchial asthma (BA) before and after thrombocytapheresis (TA). All the patients had a definite shift of platelet subpopulations to greater percentage of spherical forms as well as defects in cell ultrastructure. This makes evident platelet activation in patients with BA aggravation. TA entails a positive trend to normalization of platelet subpopulations and cytoskeleton. The ability to normalize platelet morphofunctional status determines its clinical effectiveness in bronchial asthma.
Tatarskiĭ
A R
AR
Alieva
K M
KM
Buriachkovskaia
L I
LI
Petrova
L E
LE
Bobkov
E V
EV
Chuchalin
A G
AG
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood* / Q000628:therapy; D001792:Blood Platelets / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010976:Platelet Count; D010983:Plateletpheresis
Morfologicheskie svoĭstva trombotsitov krovi u bol'nykh bronkhial'noĭ astmoĭ do i posle trombotsitafereza.