Landau-Kleffner syndrome with continuous spikes and waves during slow-wave sleep.
The Landau-Kleffner syndrome is sometimes associated with continuous spike-waves during slow-wave sleep. The clinical significance of this association is unclear. In order to investigate differences in glucose metabolic patterns between awake and sleep states in two children with Landau-Kleffner syndrome and continuous spike-waves during slow-wave sleep, fluorodeoxyglucose positron-emission tomographic (PET) studies were performed in each state. In the first patient, the awake interictal PET study revealed moderate hypometabolism in the thalamus and frontal and temporal cortex and mild hypometabolism in the parietal and anterior cingulate cortex bilaterally. Occipital cortex was severely hypometabolic bilaterally. In a repeat PET study performed during sleep in which continuous spike-waves during slow-wave sleep were present, the only difference noted compared to the awake study was a marked bilateral increase in temporal cortex metabolism. The awake interictal PET in the second child was normal, except for mildly increased relative glucose metabolism in the left inferior temporal cortex. The sleep PET study with continuous spike-waves during slow-wave sleep in this child showed hypermetabolism in both temporal lobes; however, this was more pronounced, with a wider distribution in the left temporal cortex. In normal subjects, PET studies performed during awake and sleep states have not revealed such differences. Whether the temporal lobes are involved in the generation of continuous spike-waves during slow-wave sleep remains to be confirmed in a larger group of patients. The first child was treated surgically with multiple subpial transection, following which continuous spike-waves during slow-wave sleep disappeared and language function improved.(ABSTRACT TRUNCATED AT 250 WORDS)
Rintahaka
P J
PJ
Department of Pediatrics, UCLA School of Medicine, USA.
Chugani
H T
HT
Sankar
R
R
D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D004830:Epilepsy, Tonic-Clonic / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D007805:Language Development Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D017286:Polysomnography; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D012894:Sleep Stages / Q000502:physiology*; D013577:Syndrome; D013702:Temporal Lobe / Q000503:physiopathology / Q000601:surgery; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose