GLUT-1 glucose transporter is localized heterogeneously within the microvessels of the mouse hippocampus.
We investigated the distribution of the glucose transporter protein within the microvessels in the mouse hippocampus by immunohistochemical methods with an anti-rat brain glucose transporter 1 (GLUT-1) and confocal laser scanning microscopy. All intraparenchymal microvessels in the hippocampus showed intensive immunoreactivity and a heterogeneous distribution of GLUT-1 was seen in the microvessels. These data may suggest that glucose could be heterogeneously incorporated into the endothelial cells of the cerebral microvessels, and therefore morphological and physiological differences may be present among the endothelial cells.
Kawamoto
S
S
Department of Anatomy, Osaka Medical College, Japan.
Goto
H
H
Watanabe
M
M
Shimada
M
M
D000818:Animals; D001360:Avidin; D001710:Biotin; D002196:Capillaries / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology; D051272:Glucose Transporter Type 1; D006624:Hippocampus / Q000098:blood supply* / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018613:Microscopy, Confocal; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*
D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; C495678:Slc2a1 protein, mouse; D001360:Avidin; D001710:Biotin