Evan's blue dye blocks capsaicin-induced cough and bronchospasm in the guinea pig.
The influence of Evan's blue dye on capsaicin-induced bronchoconstrictor and cough responses was investigated in the guinea pig. Evan's blue (30 mg kg-1 i.v.) pretreatment shifted the bronchoconstrictor dose-response to capsaicin (0.3-100 micrograms kg-1 i.v.) to the right by 10-fold, but had no effect on the bronchospasm elicited by neurokinin A (0.3-10 micrograms kg-1 i.v.). Evan's blue (0.3-30 mg kg-1 s.c.) also inhibited capsaicin-induced cough in a dose-dependent manner. Evan's blue blocked capsaicin responses by the intravenous, subcutaneous, or inhaled routes of administration. We conclude bronchoconstrictor responses and cough in vivo.
Bolser
D C
DC
Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Del Prado
M
M
O'Reilly
S
S
Mingo
G
G
Hey
J A
JA
D000818:Animals; D001986:Bronchial Spasm / Q000517:prevention & control*; D002211:Capsaicin / Q000494:pharmacology*; D003371:Cough / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005070:Evans Blue / Q000494:pharmacology*; D006168:Guinea Pigs
D005070:Evans Blue; D002211:Capsaicin