Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling.
The effects of the mycotoxin citrinin on renal cortical and liver mitochondrial swelling were studied. Citrinin decreases the rate of swelling induced by the valinomycin-K+ complex, suggesting that the mycotoxin interferes with the mitochondrial membrane fluidity. Citrinin promotes reduction of the amplitude of swelling in the presence of Na+ ions. This alteration reflects interference with complex I of the respiratory chain and ATP synthase complex activity without disarranging the inner mitochondrial membrane, in view of the fact that the shrinkage was not affected. The effect increases with citrinin concentration. Renal tissue is more susceptible than hepatic tissue.
Chagas
G M
GM
Departamento de Bioquímica da Universidade Federal do Paraná, Brasil.
Oliveira
M B
MB
Campello
A P
AP
Klüppel
M L
ML
D000818:Animals; D002953:Citrinin / Q000494:pharmacology / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007672:Kidney Cortex / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000494:pharmacology; D014634:Valinomycin / Q000494:pharmacology
D014634:Valinomycin; D002953:Citrinin; D012964:Sodium