[Changes in the phosphoinositide metabolism in the blood and tissues of benign and malignant uterine tumors].
Measurements of phosphoinositide levels in the blood, immunocompetent cells, and tumors of 105 patients with uterine myomas, 24 patients with cancer of the corpus uteri, and 17 ones with uterine sarcoma showed that the parameters of phosphoinositide metabolism in the blood of patients with tumors of the uterus reliably differed from those in healthy women. The content of phosphatidylinosites and other phosphoinositide fractions in patients with uterine myomas reliably differed from those in patients with malignant tumors of the uterus, this permitting the use of such measurements in the differential diagnosis. Phosphoinositide mechanism of development of tumors of the uterus is discussed, which is related to the "new" phosphoinositides and secondary messengers directly participating in transfer of cell growth signals.
Damirov
M M
MM
Sliusar'
N N
NN
Kulakov
V I
VI
Bakuleva
I P
IP
Matruk
T A
TA
D000328:Adult; D001402:B-Lymphocytes / Q000737:chemistry / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000737:chemistry / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D010716:Phosphatidylinositols / Q000032:analysis / Q000378:metabolism*; D012509:Sarcoma / Q000737:chemistry / Q000175:diagnosis / Q000378:metabolism*; D013601:T-Lymphocytes / Q000737:chemistry / Q000378:metabolism; D014594:Uterine Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000378:metabolism*
D010716:Phosphatidylinositols
Izmenenie fosfoinozitidnogo obmena v krovi i tkani dobrokachestvennykh i zlokachestvennykh opukholeĭ matki.