title: On the cellular localization and distribution of carbonic anhydrase II immunoreactivity in the rat brain.
abstract: Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO2 formed in activated axons may, via carbonic anhydrase-II, give rise to protons controlling the excitability of surrounding neuropil. Thus, CO2 may represent an important, highly diffusible, signal in brain, involved in the tonic control of neuronal activity.
authors.affiliation: Department of Human Physiology, University of Modena, Italy.
authors.forename: L F
authors.initials: LF
authors.lastname: Agnati
authors.forename: B
authors.initials: B
authors.lastname: Tinner
authors.forename: W A
authors.initials: WA
authors.lastname: Staines
authors.forename: K
authors.initials: K
authors.lastname: Väänänen
authors.forename: K
authors.initials: K
authors.lastname: Fuxe
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000201:enzymology; D002245:Carbon Dioxide / Q000378:metabolism / Q000502:physiology; D002256:Carbonic Anhydrases / Q000378:metabolism* / Q000502:physiology; D002421:Caudate Nucleus / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology*; D005455:Fluorescent Antibody Technique; D006624:Hippocampus / Q000201:enzymology; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008297:Male; D009714:Nucleus Accumbens / Q000201:enzymology; D009836:Oligodendroglia / Q000201:enzymology; D011699:Putamen / Q000201:enzymology; D051381:Rats
chemical_list: D002245:Carbon Dioxide; D002256:Carbonic Anhydrases