Inhibitory motor seizures: correlation with centroparietal structural and functional abnormalities.
Six adults and 2 children with focal inhibitory motor seizures (ictal paralysis) were evaluated during a 4-year period. Paresthesias at seizure onset occurred during some seizures in all patients, and focal clonic activity followed paralysis in 4. EEG-CCTV recordings of the seizures in 2 patients showed that ictal paralysis coincided with an ictal discharge starting in one centroparietal area. MRI showed centroparietal structural lesions in six patients. One patient with a normal MRI scan had right centroparietal hypometabolism on PET. Inhibitory motor seizures must be differentiated from transient ischemic attacks and migraine. In our patients a centroparietal epileptogenic focus was suggested by neuroimaging studies, and in 2 instances by ictal EEG.
Abou-Khalil
B
B
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA.
Fakhoury
T
T
Jennings
M
M
Moots
P
P
Warner
J
J
Kessler
R M
RM
D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004734:Energy Metabolism / Q000502:physiology; D004829:Epilepsy, Generalized / Q000473:pathology / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000503:physiopathology; D006429:Hemiplegia / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008068:Lipomatosis / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009433:Neural Inhibition / Q000502:physiology*; D010243:Paralysis / Q000473:pathology / Q000503:physiopathology*; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology*; D014055:Tomography, Emission-Computed; D014741:Video Recording