title: Improvement in exercise capacity of candidates awaiting heart transplantation.
abstract: OBJECTIVE
  This study determined the frequency of improvement in peak oxygen uptake and its role in reevaluation of candidates awaiting heart transplantation.
  
  
  BACKGROUND
  Ambulatory candidates for transplantation usually wait > 6 months to undergo the procedure, and during this period symptoms may lessen, and peak oxygen uptake may improve. Whereas initial transplant candidacy is based increasingly on objective criteria, there are no established guidelines for reevaluation to determine who can leave the active waiting list.
  
  
  METHODS
  All ambulatory transplant candidates with initial peak oxygen uptake < 14 ml/kg per min were identified. Of 107 such patients listed, 68 survived without early deterioration or transplantation to undergo repeat exercise. A strategy of reevaluation using specific clinical criteria and exercise performance was tested to determine whether patients with improved oxygen uptake could safely be followed without transplantation.
  
  
  RESULTS
  In 38 of the 68 patients, peak oxygen uptake increased by > or = 2 ml/kg per min to a level > or = 12 ml/kg per min after 6 +/- 5 months, together with an increase in anaerobic threshold, peak oxygen pulse and exercise heart rate reserve and a decrease in heart rate at rest. Increased peak oxygen uptake was accompanied by stable clinical status without congestion in 31 of 38 patients, and these 31 were taken off the active waiting list. At 2 years, their actuarial survival rate was 100%, and the survival rate without relisting for transplantation was 85%.
  
  
  CONCLUSIONS
  Reevaluation of exercise capacity and clinical status allowed removal of 31 (29%) of 107 ambulatory transplant candidates from the waiting list with excellent early survival despite low peak oxygen uptake on initial testing. The ability to increase peak oxygen uptake, particularly with increased peak oxygen pulse, may indicate improved prognosis as well as functional capacity and, in combination with stable clinical status, may be an indication to defer transplantation in favor of more compromised candidates.
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard University School of Medicine, Boston, Massachusetts 02115.
authors.forename: L W
authors.initials: LW
authors.lastname: Stevenson
authors.forename: A E
authors.initials: AE
authors.lastname: Steimle
authors.forename: G
authors.initials: G
authors.lastname: Fonarow
authors.forename: M
authors.initials: M
authors.lastname: Kermani
authors.forename: D
authors.initials: D
authors.lastname: Kermani
authors.forename: M A
authors.initials: MA
authors.lastname: Hamilton
authors.forename: J D
authors.initials: JD
authors.lastname: Moriguchi
authors.forename: J
authors.initials: J
authors.lastname: Walden
authors.forename: J H
authors.initials: JH
authors.lastname: Tillisch
authors.forename: D C
authors.initials: DC
authors.lastname: Drinkwater
mesh_terms: D000293:Adolescent; D000368:Aged; D000704:Analysis of Variance; D006328:Cardiac Catheterization; D005080:Exercise Test / Q000706:statistics & numerical data; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D016027:Heart Transplantation / Q000401:mortality / Q000502:physiology* / Q000706:statistics & numerical data; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D017741:Survivors