The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein.
An unusually small (8 kD) protein (p8MTCP-1) is coded by the putative oncogene MTCP-1 (also called c6.1B), involved in the translocation t(X;14)(q28;q11) associated with some mature T-cell proliferations. Here, we show by subcellular fractionation and by confocal microscopy that this protein is located in the mitochondria. This localization orientates toward a role of p8MTCP-1 in the mitochondrial metabolism which may be relevant for the oncogenic process.
Madani
A
A
Laboratoire d'Hématologie Moléculaire, Hôpital Saint Louis, Paris, France.
Soulier
J
J
Schmid
M
M
Plichtova
R
R
Lermé
F
F
Gateau-Roesch
O
O
Garnier
J P
JP
Pla
M
M
Sigaux
F
F
Stern
M H
MH
D000595:Amino Acid Sequence; D005455:Fluorescent Antibody Technique; D006801:Humans; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000378:metabolism*; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics; D017386:Sequence Homology, Amino Acid
C082870:MTCP1 protein, human; D011518:Proto-Oncogene Proteins