title: Effects of thyroid hormone on coenzyme Q and other free radical scavengers in rat heart muscle.
abstract: Active oxygen species are reported to cause organ damage. This study was therefore designed to determine the behaviour of antioxidants and free radical scavengers so as to reveal changes in animals in the hyper- and hypothyroid state. Levels of antioxidant factors (i.e. coenzyme Q (CoQ)10, CoQ9 and vitamin E) and free radical scavengers (catalase, glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD)) were measured in the heart muscles of rats rendered hyper- or hypothyroid by 4 weeks of thyroxine (T4) or methimazol treatment. Serum levels of CoQ9 and total SOD were also measured. A significant reduction in CoQ9 levels was observed in the heart muscles of both hyper- and hypothyroid rats when compared with control hearts. There was no difference in serum CoQ9 levels in thyroid dysfunction when compared with control animals. Levels of vitamin E in the heart muscles of hyperthyroid rats were significantly increased, and there was no reduction in vitamin E levels in hypothyroid rats when compared with control hearts. GSH-PX levels in the heart muscle were reduced in hyperthyroid rats and increased in hypothyroid rats when compared with control hearts. However, there were no differences in catalase levels in heart muscle between hyper- and hypothyroid rats. The concentration of SOD in heart muscle was increased in hyperthyroid rats and was not decreased in hypothyroid rats compared with control rats, suggesting the induction of SOD by excessive production of O2-. These data suggest that the changes in these scavengers have some role in cardiac dysfunction in the hyper- and hypothyroid state in the rat.
authors.affiliation: Department of Internal Medicine, Fujita Health University School of Medicine, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mano
authors.forename: R
authors.initials: R
authors.lastname: Sinohara
authors.forename: Y
authors.initials: Y
authors.lastname: Sawai
authors.forename: N
authors.initials: N
authors.lastname: Oda
authors.forename: Y
authors.initials: Y
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Mokuno
authors.forename: M
authors.initials: M
authors.lastname: Kotake
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: R
authors.initials: R
authors.lastname: Masunaga
authors.forename: A
authors.initials: A
authors.lastname: Nakai
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003067:Coenzymes; D016166:Free Radical Scavengers / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013963:Thyroid Hormones / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism
chemical_list: D003067:Coenzymes; D016166:Free Radical Scavengers; D013963:Thyroid Hormones; D014280:Triglycerides; D014451:Ubiquinone; D014810:Vitamin E; D008713:Methimazole; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C024989:coenzyme Q10; C030571:ubiquinone 9; D013974:Thyroxine