KR-25003, a potent analgesic capsaicinoid.
The crystal structure of N-[3-(3,4-dimethylphenyl)propyl] (4-hydroxy-3-methoxyphenyl)acetamide, C20H25NO3, was determined to a final R value of 0.047. The vanilloid, amide and dimethylphenyl groups of the compound are nearly perpendicular with respect to one another. The overall conformation in the crystalline state is somewhat different from that of other capsaicinoids. The molecules are stabilized by intermolecular hydrogen bonds.
Park
N S
NS
Korea Research Institute of Chemical Technology, Taejon.
Park
I Y
IY
Lee
J C
JC
Kim
Y B
YB
D000700:Analgesics / Q000737:chemistry*; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000737:chemistry; D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D015394:Molecular Structure
D000700:Analgesics; C094051:KR 25003; D002211:Capsaicin