[Efficacy of oral administration of a micellaar solution of vitamin K during the neonatal period].
BACKGROUND
Oral administration of vitamin K to neonates is quite satisfactory for preventing hemorrhagic disease of the newborn. The aim of this study is to test efficacy of a micellar solution of vitamin K at birth.


METHODS
Thirty full term infants, exclusively breast-fed during the first month of life, were included in this study. Seven of them (control group Cos) were given oral supplementation with 5 mg vitamin K1, cremophor; 15 other infants were given oral supplementation with 3 mg micellar solution of vitamin K1 (group MMos) and 7 were given an intramuscular injection of 1.5 mg micellar solution of vitamin K1 (group MMim). Prothrombin time activity and plasma vitamin K concentration were measured in the cord blood, 24 +/- 12 hours and 1 month after supplementation.


RESULTS
No hemorrhage was seen and tolerance to vitamin K was good in the 3 groups. Mean prothrombin time activity was 54% in the cord blood, around 55% and 75%, 24 hrs and 1 month after supplementation, respectively; only one infant had low value (41%) by 1 month despite normal plasma vitamin K concentration. Two infants had low plasma vitamin K1 concentration by the second control despite normal prothrombin time activity; one belonged to the MMos group and the other to the Cos group. Mean values of plasma vitamin K1 concentration were higher by 1 month in the MMos group.


CONCLUSIONS
A unique dose of micellar solution of vitamin K given orally at birth seems effective to prevent hemorrhagic disease.
Maurage
C
C
Service de pédiatrie R-gastroentérologie et nutrition, hôpital Clocheville, CHU Tours, France.
Dalloul
C
C
Moussa
F
F
Cara
B
B
Dudragne
D
D
Lion
N
N
Amédée-Manesme
O
O
D000284:Administration, Oral; D001942:Breast Feeding; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D008823:Micelles; D011516:Prothrombin / Q000032:analysis; D012996:Solutions; D014812:Vitamin K / Q000008:administration & dosage*; D010837:Vitamin K 1 / Q000008:administration & dosage* / Q000627:therapeutic use; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control
D008823:Micelles; D012996:Solutions; D014812:Vitamin K; D010837:Vitamin K 1; D011516:Prothrombin
Efficacité de l'administration orale d'une solution micellaire de vitamine K en période néonatale.