[Apoptosis of mouse MS-2 fibrosarcoma cells induced by photodynamic therapy with LDL-administered zinc-phthalocyanine].
Photodynamic destruction of MS-2 fibrosarcoma cells in mice induced by LDL-administered Zinc-phthalocyanine and red light irradiation was studied by electron microscopy. The pronounced structural changes such as chromatin condensation, disappearance of nuclear pores, karyopyknosis, karyorrhexis, leakage of chromatin aggregates, autophagocytosis, bleb formation on the cell surface, cytoplasmic vacuolization and cell fragmentation suggest that the tumor cell death was induced by apoptosis. However, its exact mechanism and regulating pathways remain to be further investigated.
Zhou
C
C
Cancer Institute, CAMS, Beijing.
Chi
S
S
Deng
J
J
Liang
J
J
Biolo
R
R
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology / Q000648:ultrastructure*; D007211:Indoles / Q000494:pharmacology*; D008027:Light; D008077:Lipoproteins, LDL; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D015032:Zinc
D007211:Indoles; D008077:Lipoproteins, LDL; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C064328:zinc phthalocyanine sulfonate; D015032:Zinc