title: Serum neuron-specific enolase in human status epilepticus.
abstract: Neuron-specific enolase (NSE) is a sensitive marker of brain injury after stroke, global ischemia, and coma. We report changes in serum NSE (s-NSE) in 19 patients who sustained status epilepticus. s-NSE peaked within 24 to 48 hours after status epilepticus. The mean peak s-NSE level for the entire group was elevated compared with the levels for normal controls (24.87 ng/ml versus 5.36 ng/ml, p = 0.0001) and for epileptic controls (24.87 ng/ml versus 4.61 ng/ml, p = 0.0001). The mean peak s-NSE level for the 11 subjects without an acute neurologic insult (15.44 ng/ml) was also significantly increased compared with levels for normal and epileptic controls. Further, s-NSE was significantly correlated with outcome and duration. We conclude that s-NSE is a promising in vivo marker of brain injury in status epilepticus and warrants further study in larger populations.
authors.affiliation: Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: DeGiorgio
authors.forename: J D
authors.initials: JD
authors.lastname: Correale
authors.forename: P S
authors.initials: PS
authors.lastname: Gott
authors.forename: D L
authors.initials: DL
authors.lastname: Ginsburg
authors.forename: K A
authors.initials: KA
authors.lastname: Bracht
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Boutros
authors.forename: W J
authors.initials: WJ
authors.lastname: Loskota
authors.forename: A L
authors.initials: AL
authors.lastname: Rabinowicz
mesh_terms: D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D013226:Status Epilepticus / Q000097:blood*
chemical_list: D010751:Phosphopyruvate Hydratase