Gamma chain-associated cytokine receptors signal through distinct transducing factors.
The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand-specific binding chains that associate with a shared signaling subunit, the common gamma (gamma c) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the gamma c-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.
Pernis
A
A
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Gupta
S
S
Yopp
J
J
Garfein
E
E
Kashleva
H
H
Schindler
C
C
Rothman
P
P
D000595:Amino Acid Sequence; D001483:Base Sequence; D002460:Cell Line; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D018123:Receptors, Interleukin / Q000378:metabolism*; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism
D007378:Interleukins; D018123:Receptors, Interleukin; D014443:Tyrosine