title: Human leucocyte antigen phenotypes and gold-induced remissions in patients with rheumatoid arthritis.
abstract: To assess possible associations between human leucocyte antigens (HLA) and the achievement of remission during gold treatment, HLA typing was performed in 67 rheumatoid arthritis (RA) patients with a gold-induced remission and in 25 control RA patients who discontinued gold therapy because of lack of efficacy. Both groups of RA patients showed a significantly higher frequency of DR4 antigen and lower frequency of DR6 than a control population. There were no significant differences in HLA antigens between remission-responders and non-responders. It is concluded that HLA typing is not helpful in predicting the therapeutic response to parenteral gold therapy.
authors.affiliation: Department of Rheumatology, University Hospital Leiden, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: ten Wolde
authors.forename: B A
authors.initials: BA
authors.lastname: Dijkmans
authors.forename: J J
authors.initials: JJ
authors.lastname: van Rood
authors.forename: F H
authors.initials: FH
authors.lastname: Claas
authors.forename: R R
authors.initials: RR
authors.lastname: De Vries
authors.forename: J M
authors.initials: JM
authors.lastname: Hazes
authors.forename: P L
authors.initials: PL
authors.lastname: van Riel
authors.forename: A
authors.initials: A
authors.lastname: van Gestel
authors.forename: F C
authors.initials: FC
authors.lastname: Breedveld
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology*; D005260:Female; D006046:Gold / Q000627:therapeutic use*; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000032:analysis; D015808:HLA-DR6 Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012074:Remission Induction
chemical_list: D006680:HLA Antigens; D015804:HLA-DR4 Antigen; D015808:HLA-DR6 Antigen; D006046:Gold