title: Scopulariopsis endocarditis associated with Duran ring valvuloplasty.
abstract: Fungal endocarditis is rare and is usually caused by Aspergillus and Candida species. We present a patient with endocarditis caused by Scopulariopsis brevicaulis. The patient had a history of mitral valve disease and, 1 year earlier, had undergone valvuloplasty with the placement of a prosthetic Duran ring in the mitral valve position. S. brevicaulis was cultured from samples of a large vegetation on the mitral valve apparatus. The mitral valve was replaced with a St. Jude mechanical prosthesis. The patient was treated with amphotericin B but was later switched to oral itraconazole when antibiotic tests indicated susceptibility to that agent. We believe this is the 1st reported case of endocarditis caused by Scopulariopsis.
authors.affiliation: Infectious Disease Section, St. Luke's Episcopal Hospital, Houston, Texas 77030, USA.
authors.forename: L O
authors.initials: LO
authors.lastname: Gentry
authors.forename: M M
authors.initials: MM
authors.lastname: Nasser
authors.forename: M
authors.initials: M
authors.lastname: Kielhofner
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D004696:Endocarditis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008297:Male; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects / Q000648:ultrastructure; D008943:Mitral Valve / Q000473:pathology; D008944:Mitral Valve Insufficiency / Q000473:pathology / Q000601:surgery*; D009181:Mycoses / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012086:Reoperation; D012214:Rheumatic Heart Disease / Q000473:pathology / Q000601:surgery*
chemical_list: D017964:Itraconazole