title: Passive urethral resistance to dilation in healthy women: an experimental simulation of urine ingression in the resting urethra.
abstract: The dynamic urethral pressure response to a simulated urine ingression was studied at the bladder neck, in the high pressure zone, and in the distal urethra in 10 healthy female volunteers. The pressure response was characterised by a steep pressure increase simulataneous with the urethral dilation, followed by a decay during the next seconds until a new equilibrium pressure was reached. The pressure decay could be described by a double exponential function in the form Pt = Pequ + P alpha e-t/tau alpha + P beta e-t/tau beta, where Pt represents the pressure at the time t, Pequ represents the pressure at equilibrium, P alpha and P beta express the decline in pressure, and tau alpha and tau beta are time constants. The size of the pressure response proved highly dependent on velocity and size of dilation as well as urethral site of measurement, with the maximum values in the high pressure zone. The time constants, on the other hand, were uninfluenced by these factors. The pressure response represents an integrated stress response from the surrounding tissues which may reflect the visco-elastic properties of the structures involved. The findings indicate that striated muscle fibres are of dominating significance for the pressure response, and the varying size of the response along the urethra is in accordance with the localization of the horseshoe-shaped rhabdosphincter, which quantitatively is the dominating circularly arranged structure around the female urethra. Functionally, the stress response will oppose any dilation, and increasingly with rising size or velocity of dilation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Urology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Bagi
authors.forename: P
authors.initials: P
authors.lastname: Thind
authors.forename: M
authors.initials: M
authors.lastname: Nordsten
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D014521:Urethra / Q000502:physiology*; D014554:Urination; D014556:Urine / Q000502:physiology*; D014563:Urodynamics / Q000502:physiology; D014572:Urology / Q000379:methods*