[Value of the TAG-72 (CA 72-4) tumor marker in primary diagnosis of ovarian carcinoma. A comparison with the established CA-125 marker].
The value of the TAG-72 (CA 72-4) serum marker in primary diagnosis was investigated in 110 patients with histologically diagnosed ovarian cancer. A reference group consisted of 103 patients with benign pelvic masses. Compared to the well-established CA-125, TAG-72 showed a low sensitivity of 42% in the detection of ovarian cancer. By contrast, when the cut-off level for TAG-72 was set at 6 U/ml, it showed a very high specificity of 99%. When the measurement of TAG-72 was combined to that of CA-125, improvements in both the specificity (as compared to a single CA-125 determination) and the sensitivity (as compared to a single TAG-72 assay) were observed. In such a combined assay, our results suggest that the best predictive value (positive and negative) was obtained if CA-125 is assigned a relatively high cut-off value (65 U/ml) in conjunction with a low cut-off level (3.2 U/ml or 4 U/ml) for TAG-72. In the present study, at threshold values of 65 U/ml respectively, a sensitivity of 86%, a specificity of 83% and a positive and negative predictive value of 85% were obtained. In mucinous carcinomas of the ovary, however, the additional TAG-72 determination did not lead to a better predictive power than did CA-125 measurement alone.
Zeimet
A G
AG
Universitätsklinik für Frauenheilkunde, Innsbruck.
Guadagni
F
F
Marth
C
C
Amato
T
T
Müller-Holzner
E
E
Huter
O
O
Daxenbichler
G
G
Dapunt
O
O
D018262:Adenocarcinoma, Clear Cell / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D000328:Adult; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D003536:Cystadenocarcinoma / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D018282:Cystadenocarcinoma, Mucinous / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D010053:Ovary / Q000473:pathology; D011230:Precancerous Conditions / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D011237:Predictive Value of Tests
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D006023:Glycoproteins; C047052:tumor-associated antigen 72
Stellenwert des Tumormarkers TAG-72 (CA 72-4) bei der Primärdiagnostik des Ovarialkarzinoms. Ein Vergleich mit dem etablierten Marker CA-125.