title: 2-Phenyl-4-(aminomethyl)imidazoles as potential antipsychotic agents. Synthesis and dopamine D2 receptor binding.
abstract: A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D2 selective benzamide antipsychotics. The title compounds were synthesized and tested for blockade of [3H]YM-09151 binding in cloned African green monkey dopamine D2 receptor preparations. The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)-pyrroles.
authors.affiliation: Department of Chemistry, Neurogen Corporation, Branford, Connecticut 06405, USA.
authors.forename: A
authors.initials: A
authors.lastname: Thurkauf
authors.forename: A
authors.initials: A
authors.lastname: Hutchison
authors.forename: J
authors.initials: J
authors.lastname: Peterson
authors.forename: L
authors.initials: L
authors.lastname: Cornfield
authors.forename: R
authors.initials: R
authors.lastname: Meade
authors.forename: K
authors.initials: K
authors.lastname: Huston
authors.forename: K
authors.initials: K
authors.lastname: Harris
authors.forename: P C
authors.initials: PC
authors.lastname: Ross
authors.forename: K
authors.initials: K
authors.lastname: Gerber
authors.forename: T V
authors.initials: TV
authors.lastname: Ramabhadran
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D016466:CHO Cells; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D006224:Cricetinae; D018076:DNA, Complementary; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D014150:Antipsychotic Agents; D018076:DNA, Complementary; D007093:Imidazoles; D017448:Receptors, Dopamine D2