Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion.
A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (< or = 1 week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-D-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]alpha-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.
Blandini
F
F
Neurological Institute C. Mondino, University of Pavia, Italy.
Porter
R H
RH
Greenamyre
J T
JT
D000818:Animals; D001345:Autoradiography; D001479:Basal Ganglia / Q000201:enzymology*; D016291:Dizocilpine Maleate / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism*; D012402:Rotenone / Q000031:analogs & derivatives / Q000378:metabolism; D013787:Thalamic Nuclei / Q000502:physiology*
D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D012402:Rotenone; C044985:1',2'-dihydrorotenone; D016291:Dizocilpine Maleate; D016660:NAD(P)H Dehydrogenase (Quinone)