Aspects of the thromboxane receptor system.
1. The aim of this review is to establish what is known about the thromboxane (TP) receptor, and to identify where future research is headed. In addition, the impact of the recent advances at the molecular level on resolving pharmacological controversies, such as possible subtypes of the TP receptor, is discussed and what molecular information is known about the TP receptor presented. 2. The clinical status of TP receptor antagonists is considered particularly in relation to the potential role of epi prostaglandins. 3. Basic information about TP agonists, antagonists and signal transduction pathways is also given.
Armstrong
R A
RA
University of Edinburgh, Department of Pharmacology, Scotland.
Wilson
N H
NH
D000818:Animals; D006801:Humans; D011453:Prostaglandins / Q000502:physiology*; D017482:Receptors, Thromboxane / Q000819:agonists / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism*
D011453:Prostaglandins; D017482:Receptors, Thromboxane