Turing structures in a system with regulated gap-junctions.
In two coupled cells, each containing a bisubstrate-kinetics reaction system, the two substrates can cross the membranes through gap-junction protein channels (gating). Passing through the gap-junctions is controlled by one of the substrates, thus resulting in non-linear diffusion. Linear stability analysis gives the conditions, under which the symmetric fixpoint becomes unstable, leading to spatial asymmetry (Turing structures). The implications for morphogenesis are discussed.
Klein
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CT
Institute of Physical and Theoretical Chemistry, University of Tübingen, Germany.
Seelig
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FF
D000818:Animals; D001693:Biological Transport, Active; D002451:Cell Compartmentation; D004058:Diffusion; D004798:Enzymes / Q000378:metabolism; D017629:Gap Junctions / Q000378:metabolism*; D015640:Ion Channel Gating; D007700:Kinetics; D008954:Models, Biological
D004798:Enzymes