A bioactive fullerene peptide.
The highly hydrophobic C60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-1,2-methanofullerene [60]-61-carboxylic acid to the alpha-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a UV spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.
Toniolo
C
C
Dipartimento di Chimica Organica, Universitá di Padova, Italy.
Bianco
A
A
Maggini
M
M
Scorrano
G
G
Prato
M
M
Marastoni
M
M
Tomatis
R
R
Spisani
S
S
Palú
G
G
Blair
E D
ED
D000595:Amino Acid Sequence; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D015717:Peptide T / Q000031:analogs & derivatives* / Q000494:pharmacology
D017320:HIV Protease Inhibitors; D015717:Peptide T