Maternal environment defines blood pressure and its response to troleandomycin in spontaneously hypertensive rats.
Relationship between family-3A cytochrome P-450-dependent (troleandomycin inhibitable) and maternal environmental-dependent systolic blood pressure (SBP) was investigated in spontaneously hypertensive rats (SHR). Adult SHR nursed by foster or natural SHR mothers had indistinguishable SBP. Troleandomycin reduced 50% of Wistar-Kyoto (WKY)-SHR strain difference in SBP. SHR having WKY foster mothers had SBP similar to troleandomycin-reduced SHR levels, which was unaffected by troleandomycin. The two components of SBP elevation appear identical. Because observations of others demonstrated that WKY fostered to SHR show no SBP increase, the maternally dependent/troleandomycin-sensitive component of SBP elevation may reflect epistatic interaction between genes determining maternal differences and offspring sensitivity, respectively.
Basu
A K
AK
Department of Medicine and Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0145, USA.
Hagley
R D
RD
Ghosh
S S
SS
Kramer
L
L
Nance
W E
WE
Watlington
C O
CO
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004777:Environment; D005260:Female; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D008425:Maternal Behavior / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013045:Species Specificity; D014217:Troleandomycin / Q000494:pharmacology*
D003577:Cytochrome P-450 Enzyme System; D014217:Troleandomycin