[Postantibiotic effects (PAE's) of macrolide antibiotics evaluated using Bioscreen C method].
Postantibiotic effects (PAE's) of macrolide antibiotics were determined for Staphylococcus aureus and Enterococcus faecalis using viable counting and Bioscreen C method and the two methods were compared. No major differences between the two methods were observed. The Bioscreen C method was less laborious than the viable counting. The durations of PAE for S. aureus following exposures to erythromycin (EM), josamycin (JM) and rokitamycin (RKM) for 2 hours at twice the MICs were in ranges of 0.85 to 1.45, 2.36 to 3.48 and 1.93 to 5.45 hours, respectively. A definite PAE of 1.0 to 5.8 hours was also observed in E. faecalis strains exposed for 2 hours to EM, JM and RKM at twice the MICs.
Okubo
T
T
Laboratory of Drug Resistance in Bacteria, Gunma University School of Medicine.
Suzuki
T
T
Fujita
K
K
Iyobe
S
S
Inoue
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development*; D001431:Bacteriological Techniques; D002452:Cell Count; D002470:Cell Survival; D013293:Enterococcus faecalis / Q000187:drug effects / Q000254:growth & development; D004917:Erythromycin / Q000494:pharmacology; D015570:Josamycin / Q000494:pharmacology; D015644:Miocamycin / Q000031:analogs & derivatives / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D015644:Miocamycin; D004917:Erythromycin; D015570:Josamycin; C033383:rokitamycin