The SWI-SNF complex: a chromatin remodeling machine?
The SWI-SNF complex plays a key role in the regulation of eukaryotic gene expression. Genetic studies in the yeast Saccharomyces cerevisiae suggest that one role for the complex is to antagonize chromatin-mediated repression of transcription. Recent biochemical studies indicate that S. cerevisiae and putative human SWI-SNF complexes use the energy of ATP hydrolysis to disrupt nucleosome structure.
Peterson
C L
CL
Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA.
Tamkun
J W
JW
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D014157:Transcription Factors