Treatment of intoxication with GV compound in laboratory rats.
Changes of some physiological functions in rats were studied following intoxication with new type of highly toxic organophosphate GV [2-dimethylaminoethyl-(dimethylamido)-fluorophosphate] in doses of 2x and 4x LD50 i.m. The intoxication has begun with increasing motoric activity followed by increased salivation, rumination and bristling. Tachypnoe and fasciculations followed by convulsions and death were observed later. Therapy of intoxication with GV compound (in dose of 2x LD50) in rats demonstrated the best antidotal effect of combination of benactyzine, atropine and HI-6. In GV intoxication in higher doses (4x LD50), therapeutic efficacy (survival of experimental animals) was limited for 24 hours. HI-6 can be therefore considered as potentially universal reactivator for the treatment of nerve agents intoxication.
Fusek
J
J
Military Medical Academy, Hradec Králové.
Bajgar
J
J
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D008297:Male; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar
D000931:Antidotes; D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; C086875:2-dimethylaminoethyl-(dimethylamido)fluorophosphate