[A simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics].
OBJECTIVE
To establish a simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics.


METHODS
A linear relationship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple method is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection.


CONCLUSIONS
The elimination half-life can be read from the regression line. The method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.
Ding
Y
Y
Department of Biomathematics, Nanjing Medical University, China.
Huang
D K
DK
Luo
J P
JP
D006207:Half-Life; D008433:Mathematics; D010599:Pharmacokinetics