title: [A simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics].
abstract: OBJECTIVE
  To establish a simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics.
  
  
  METHODS
  A linear relationship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple method is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection.
  
  
  CONCLUSIONS
  The elimination half-life can be read from the regression line. The method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.
authors.affiliation: Department of Biomathematics, Nanjing Medical University, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.forename: D K
authors.initials: DK
authors.lastname: Huang
authors.forename: J P
authors.initials: JP
authors.lastname: Luo
mesh_terms: D006207:Half-Life; D008433:Mathematics; D010599:Pharmacokinetics