Central auditory processing in Alzheimer's disease.
OBJECTIVE
This investigation was designed to determine whether people in the early to middle phases of Alzheimer's disease (AD) show impaired central auditory processing as compared with nondemented elderly.


METHODS
A peripheral and central auditory test battery was administered to 10 subjects diagnosed with mild-to-moderate AD based on a neuropsychological test battery and radiographic techniques, and a control group of 10 subjects with no evidence of dementia, matched for age, gender, and average degree of hearing loss. Immittance audiometry, pure-tone and speech audiometry, and otoacoustic emissions were recorded in all subjects. Central auditory assessment included the synthetic sentence identification with ipsilateral competing message, dichotic digits, dichotic sentence identification, pitch patterns, and duration patterns.


RESULTS
Peripheral auditory status was statistically similar between subject groups. Neither average high frequency hearing sensitivity nor mean speech recognition ability was significantly different. However, a significant difference was noted between groups for average low frequency hearing sensitivity in the left ear (p < 0.05). Subjects with AD showed slightly poorer low frequency thresholds versus matched controls. Based on analysis of performance on each measure of the central auditory test battery, the AD group scored significantly lower than the matched control group on four of the five measures utilized. Differences for right versus left ear performance were found among AD subjects.


CONCLUSIONS
Overall patterns in findings cannot be easily explained as artifacts of cognitive decline. Results support screening for central auditory dysfunction in the AD population, since impaired processing could influence psychiatric assessment of cognitive deficit as well as audiologic management of peripheral hearing loss in this population.
Strouse
A L
AL
Division of Hearing and Speech Sciences, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Hall
J W
JW
Burger
M C
MC
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology; D001301:Audiometry, Pure-Tone; D001302:Audiometry, Speech; D003072:Cognition Disorders / Q000209:etiology; D005260:Female; D006311:Hearing Disorders / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D010296:Parietal Lobe / Q000503:physiopathology; D013067:Speech Perception; D013702:Temporal Lobe / Q000503:physiopathology