title: Role of excitatory amino-acids in diethyldithiocarbamate-induced cell death in mesencephalic cultures.
abstract: The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 microM was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [3H]dopamine uptake. Moreover, DDC 1 microM greatly potentiated cell death induced by glutamate 10 and 50 microM. (+)MK801, a selective non-competitive antagonist of NMDA receptors, completely prevented the toxicity of the two neurotoxins.
authors.affiliation: Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Vaglini
authors.forename: C
authors.initials: C
authors.lastname: Pardini
authors.forename: R
authors.initials: R
authors.lastname: Maggio
authors.forename: G U
authors.initials: GU
authors.lastname: Corsini
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002478:Cells, Cultured; D004050:Ditiocarb / Q000506:poisoning*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004357:Drug Synergism; D018846:Excitatory Amino Acids / Q000502:physiology*; D018698:Glutamic Acid / Q000506:poisoning; D008636:Mesencephalon / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology
chemical_list: D018846:Excitatory Amino Acids; D018696:Neuroprotective Agents; D018698:Glutamic Acid; D016291:Dizocilpine Maleate; D004050:Ditiocarb