Intrinsic insensitivity to cadmium of the L-lactate oxidizing system in staphylococcoccus aureus.
Starved cells of cadmium-sensitive Staphylococcus aureus 17810S accumulated 109Cd via the Mn2+ porter energized by the membrane potential (delta psi) generated by L-lactate oxidation. However, Cd2+ accumulation did not result in inhibition of respiration and consequent generation of electrochemical proton gradient (delta muH+) via the respiratory chain. Thus, delta muH(+)-consuming processes, such as ATP synthesis and [14C]glutamate transport proceeded normally, despite the presence of Cd2+ in the cytoplasm. The mechanism of the intrinsic cadmium-insensitivity of the L-lactate oxidizing system is discussed.
Tynecka
Z
Z
Department of Pharmaceutical Microbiology, Medical Academy, Lublin, Poland.
Malm
A
A
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D002104:Cadmium / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D010084:Oxidation-Reduction; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism
D007773:Lactates; D002104:Cadmium; D019344:Lactic Acid; D000255:Adenosine Triphosphate