title: 5-Fluorouracil filtering surgery and neovascular glaucoma. Long-term follow-up of the original pilot study.
abstract: BACKGROUND
  The long-term efficacy and safety of filtering surgery with 5-fluorouracil (5-FU) in eyes with neovascular glaucoma are unknown.
  
  
  METHODS
  Kaplan-Meier survival curve analysis of surgical outcome was performed on all 34 patients (34 eyes) enrolled from May 1982 through April 1986 in the original pilot study of filtering surgery with 5-FU.
  
  
  RESULTS
  Success rates at the 1-, 2-, 3-, 4-, and 5-year intervals were 71%, 67%, 61%, 41%, and 28%, respectively. The median filter survival time was 38.7 months (95% confidence interval: 32-45 months). Twelve (35%) of 34 patients lost light perception vision, and phthisis bulbi developed in 8 (24%) of 34 patients. Age of 50 years or younger (P < 0.0001) and type 1 diabetes (P = 0.0004) were significant risk factors for surgical failure. The 1-year success rate for patients no older than 50 years of age was 23% compared with a 95% success rate in patients older than 50 years of age. After adjustment for age, type 1 diabetes was a borderline risk factor (P = 0.06).
  
  
  CONCLUSIONS
  There is a high risk of long-term failure of filtering surgery with 5-FU in neovascular glaucoma. Patients 50 years of age or younger have an extremely poor prognosis. Patients older than 50 years of age have initial short-term success with an accelerated failure rate after 3 years.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Tsai
authors.forename: W J
authors.initials: WJ
authors.lastname: Feuer
authors.forename: R K
authors.initials: RK
authors.lastname: Parrish
authors.forename: A L
authors.initials: AL
authors.lastname: Grajewski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018463:Filtering Surgery; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D015355:Glaucoma, Neovascular / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007431:Intraoperative Complications; D008137:Longitudinal Studies; D008875:Middle Aged; D010865:Pilot Projects; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D005472:Fluorouracil