Telomere repeat fragment sizes do not limit the growth potential of uterine leiomyomas.
We have compared the length of telomere repeat fragments (TRF's) in 19 uterine leiomyomas from 6 patients with the corresponding myometrium. The advantage of this study of TRF length is that cells from uterine leiymyoma and cells from corresponding myometrium do not contain any considerable proportions of other cells as revealed by analysis of clonality. In all tumor samples a loss of TRF length ranging from 1120 to 4690 bp was noted. There was no correlation between tumor volume or size of tumor population as revealed by histological examination and loss of TRF length. From the obtained TRF length data (an average myometrial TFR length of 13 kb and an average loss of TRF length in myoma cells of 83 bp per cell division) we concluded that TRF length reduction does not limit the growth potential of uterine leiomyomas.
Rogalla
P
P
Centre of Human Genetics and Genetic Counselling, University of Bremen, Germany.
Rohen
C
C
Hennig
Y
Y
Deichert
U
U
Bonk
U
U
Bullerdiek
J
J
D001483:Base Sequence; D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology*; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D016615:Telomere / Q000235:genetics*; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology*
D004273:DNA, Neoplasm