Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy.
We have investigated the influence of the functional insertion (I) and deletion (D) polymorphism in intron 16 of the gene for angiotensin-converting enzyme (ACE) in a retrospective study of 100 patients with IgA nephropathy. There was no difference in genotype frequency compared with normal subjects. However, patients homozygous for the D allele tended to present at an earlier age (medians: DD, 33; ID, 34; II, 42 years) and to require renal replacement therapy at a younger age (medians 37, 42, and 48 years, respectively). The rate of progression was significantly worse in patients homozygous for the D allele. The DD genotype is associated with increased severity of disease in patients with IgA nephropathy.
Harden
P N
PN
Renal Unit, Western Infirmary, Glasgow, UK.
Geddes
C
C
Rowe
P A
PA
McIlroy
J H
JH
Boulton-Jones
M
M
Rodger
R S
RS
Junor
B J
BJ
Briggs
J D
JD
Connell
J M
JM
Jardine
A G
AG
D000328:Adult; D000483:Alleles; D001483:Base Sequence; D001794:Blood Pressure / Q000502:physiology; D003404:Creatinine / Q000097:blood; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007438:Introns; D008875:Middle Aged; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies
D017931:DNA Primers; D004247:DNA; D003404:Creatinine; D007703:Peptidyl-Dipeptidase A