Cytokines as adjuvants in immunocompromised hosts.
Vaccination of immunocompromised subjects may be ineffective due to the poor immune responses induced. In addition, vaccination with live attenuated organisms may also be dangerous due to the possible lack of control of the infection. This review describes the protection of cytokines in the vaccination of immunocompromised individuals. Cytokines have possible roles as immunological adjuvants, enhancing immune responses to vaccination, and can also have effects on the growth of live vaccines or vaccine vectors.
Heath
A W
AW
Department of Medical Microbiology, University of Sheffield Medical School, UK.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D014611:Vaccination / Q000379:methods
D000276:Adjuvants, Immunologic; D016207:Cytokines