The specific inhibition of crystal growth of monohydrogen potassium L-tartrate by d-catechin.
Crystal growth of monohydrogen potassium L-tartrate in an ethanolic aqueous solution was specifically inhibited by d-catechin, but not by either its epimeric isomer at C3, l-epicatechin or by gallic acid and caffeic acid. 3D-Structure similarity search of d-catechin with two molecules of the tartrate and docking study of d-catechin with the crystal model of the tartrate suggested that d-catechin mimics a structure consisting of the two tartrate molecules in the inhibition. Differences in the conformation of the catechol moieties of d-catechin and l-epicatechin may explain the distinct inhibitory effects of the epimeric isomers.
Imajo
S
S
Institute for Biomedical Research, Suntory Ltd, Osaka, Japan.
Ishiguro
M
M
Ishiguro
K
K
Murashima
T
T
Isoi
K
K
Tanahashi
H
H
Nishino
H
H
D002392:Catechin / Q000737:chemistry*; D003196:Computer Graphics; D003460:Crystallization; D005419:Flavonoids; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012984:Software; D013644:Tartrates / Q000737:chemistry*
D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D013644:Tartrates; D002392:Catechin