[Image analysis for intercellular adhesion molecule-1 expression in MRI/lpr mice: effects of Chinese herb medicine].
To clarify the role of intercellular adhesion molecule-1 (ICAM-1) on pathogenesis of autoimmune lupus nephritis in MRL/lpr mice and the effects of Chinese herb medicine (stragalin), a computer image analysis system was used to study immunodepositions of ICAM-1, immunoglobulins and C3 in renal tissue sections of the mice. ICAM-1 was found in the mesangial area and deposited along the glomerular capillary walls in MRL/lpr mice. The distribution intensity of ICAM-1, immunoglobulins and C3 were significantly decreased after treatment with stragalin in form of decoction per os in the mice. We found that ICAM-1 might play an important role in pathogenesis of autoimmune lupus nephritis in MRL/lpr mice and Chinese herb medicine has some inhibition effects on immunodepositions in renal tissue of MRL/lpr mice.
Chen
X
X
Department of Nephrology, Chinese PLA General Hospital, Beijing.
Yu
L
L
Lu
Y
Y
D000818:Animals; D003176:Complement C3 / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005920:Glomerular Mesangium / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism* / Q000502:physiology; D008181:Lupus Nephritis / Q000209:etiology / Q000378:metabolism*; D051379:Mice
D003176:Complement C3; D004365:Drugs, Chinese Herbal; D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D018799:Intercellular Adhesion Molecule-1