title: Inositol 1,4,5-trisphosphate receptors, secretory granules and secretion in endocrine and neuroendocrine cells.
abstract: Recent studies have revealed the presence of inositol 1,4,5-trisphosphate receptors in the secretory granules of endocrine and neuroendocrine cells. This distribution suggests that inositol 1,4,5-trisphosphate-regulated release of granule stores of Ca2+ might facilitate the secretory process. In addition, inositol 1,4,5-trisphosphate receptors might participate directly in the biogenesis of secretory granules. The presence of inositol 1,4,5-trisphosphate receptors in synaptic nerve terminals raises the possibility that they might also be involved in the control of neurotransmitter release.
authors.affiliation: Division of Molecular Medicine, Chiba University School of Medicine, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Blondel
authors.forename: G I
authors.initials: GI
authors.lastname: Bell
authors.forename: S
authors.initials: S
authors.lastname: Seino
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism* / Q000502:physiology; D003594:Cytoplasmic Granules / Q000378:metabolism*; D004702:Endocrine Glands / Q000166:cytology / Q000378:metabolism*; D005089:Exocytosis; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007425:Intracellular Membranes / Q000378:metabolism; D009490:Neurosecretory Systems / Q000166:cytology / Q000378:metabolism*; D009994:Osmolar Concentration; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism* / Q000502:physiology; D013569:Synapses / Q000502:physiology
chemical_list: D015220:Calcium Channels; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D002118:Calcium