title: Ganglioside GD1a generates domains of high curvature in phosphatidylethanolamine liposomes as determined by solid state 31P-NMR spectroscopy.
abstract: We have studied the effects of gangliosides on the polymorphic behaviour of phosphatidylethanolamines. The ganglioside GD1a promotes the formation of phases which give rise to isotropic 31P-NMR resonance lines, particularly in the temperature range of the L alpha to HII transition. In addition, higher mol fractions of ganglioside raise the L alpha to HII phase transition temperature. Our results demonstrate that small mol fractions of gangliosides can have profound effects on the molecular organization of phosphatidylethanolamines.
authors.affiliation: Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
authors.forename: L C
authors.initials: LC
authors.lastname: van Gorkom
authors.forename: J J
authors.initials: JJ
authors.lastname: Cheetham
authors.forename: R M
authors.initials: RM
authors.lastname: Epand
mesh_terms: D002152:Calorimetry, Differential Scanning; D005732:Gangliosides / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D005732:Gangliosides; D008081:Liposomes; D010714:Phosphatidylethanolamines; C021298:ganglioside, GD1a