Trachyspic acid, a new metabolite produced by Talaromyces trachyspermus, that inhibits tumor cell heparanase: taxonomy of the producing strain, fermentation, isolation, structural elucidation, and biological activity.
Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191. Its structure was deduced from NMR spectral analyses and chemical reactions as a tricarboxylic acid derivative containing a spiroketal. The IC50 value of trachyspic acid against heparanase was 36 microM.
Shiozawa
H
H
Biomedical Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Takahashi
M
M
Takatsu
T
T
Kinoshita
T
T
Tanzawa
K
K
Hosoya
T
T
Furuya
K
K
Takahashi
S
S
Furihata
K
K
Seto
H
H
D001203:Ascomycota / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005966:Glucuronidase; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental / Q000201:enzymology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D000099175:Heparanase
D004791:Enzyme Inhibitors; D005966:Glucuronidase; D006026:Glycoside Hydrolases; D013141:Spiro Compounds; D000099175:Heparanase; C094346:trachyspic acid