[Comparison of complement activation between tuberculous and malignant pleuritis].
Complement activation products in pleural effusions were studied to clarify the causes of tuberculous and malignant pleuritis. Pleural SC5b-9, an activation product of complement common pathway, was significantly higher in tuberculous effusions than in malignant ones. In the tuberculous effusions, the levels of SC5b-9 and LDH (a marker of tissue damage) were significantly correlated, but in the malignant effusions these two values were not correlated. In the tuberculous effusions, SC5b-9 and Bb values were significantly correlated, but SC5b-9 and C4d were not, and nor were SC5b-9 and immune complex. In the malignant effusions, SC5b-9 and Bb values were low and were not significantly correlated. These results suggest that complement activation plays a significant role in tuberculous pleuritis, but not in malignant pleuritis.
Hidaka
K
K
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Abe
M
M
Tanaka
T
T
Mitsuyama
T
T
Hara
N
N
Hara
N
N
D000936:Antigen-Antibody Complex / Q000378:metabolism; D003167:Complement Activation; D003181:Complement C4 / Q000378:metabolism; D015935:Complement C4b; D015938:Complement Membrane Attack Complex; D003165:Complement System Proteins / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D010996:Pleural Effusion / Q000276:immunology; D016066:Pleural Effusion, Malignant / Q000276:immunology*; D014396:Tuberculosis, Pleural / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003181:Complement C4; D015938:Complement Membrane Attack Complex; D006023:Glycoproteins; D010446:Peptide Fragments; C047610:SC5b-9 protein complex; D015935:Complement C4b; C032261:complement C4d; D003165:Complement System Proteins; D007770:L-Lactate Dehydrogenase