A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus.
A vacuole-formation substance, cereulide of Bacillus cereus, is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in Suncus murinus, a new animal model of emesis. Vagotomy or a 5-HT3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5-HT3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells.
Agata
N
N
Nagoya City Public Health Research Institute, Japan.
Ohta
M
M
Mori
M
M
Isobe
M
M
D000818:Animals; D001409:Bacillus cereus / Q000472:pathogenicity*; D001427:Bacterial Toxins / Q000633:toxicity*; D047630:Depsipeptides; D004639:Emetics / Q000633:toxicity*; D008297:Male; D010456:Peptides, Cyclic / Q000633:toxicity*; D011985:Receptors, Serotonin / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology; D012788:Shrews
D001427:Bacterial Toxins; D047630:Depsipeptides; D004639:Emetics; D010456:Peptides, Cyclic; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C089294:cereulide