Disposition kinetics and dosage regimen of cefotaxime in cross-bred male calves.
The disposition kinetics and dosage regimen of cefotaxime were investigated in cross-bred calves following a single intravenous administration of cefotaxime (10 mg/kg). The elimination rate constant and elimination half-life were 0.273 +/- 0.060 h-1 and 3.48 +/- 1.17 h, respectively. The apparent volume of distribution (Vd area) and total plasma clearance were 3.51 +/- 0.66 l/kg and 0.81 +/- 0.10 l.kg-1.h-1, respectively. To maintain a minimum therapeutic concentration of 0.6 microgram/ml, a satisfactory intravenous dosage regimen of cefotaxime in calves should be 11 mg/kg followed by 9 mg/kg at 6 h.
Sharma
S K
SK
Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
Srivastava
A K
AK
Bal
M S
MS
D000818:Animals; D002417:Cattle / Q000378:metabolism*; D002439:Cefotaxime / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male
D002439:Cefotaxime