title: Psychosis in an adolescent patient with Wilson's disease: effects of chelation therapy.
abstract: Wilson's disease is a rare genetic disorder involving the liver and brain, with onset frequently in adolescence. Psychiatric symptoms are often the first manifestation of the disease and can obscure the diagnosis. Chelation therapy can reverse the fatal outcome of untreated patients, so early detection is critically important. This paper describes an adolescent with Wilson's disease who, after initiation of penicillamine therapy, developed florid psychosis that improved as copper levels were decreased and that did not require use of neuroleptic medication.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, Kansas City 66160-7341, USA.
authors.forename: L V
authors.initials: LV
authors.lastname: McDonald
authors.forename: C R
authors.initials: CR
authors.lastname: Lake
mesh_terms: D000293:Adolescent; D003300:Copper / Q000652:urine; D005500:Follow-Up Studies; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000523:psychology / Q000652:urine; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000523:psychology / Q000652:urine; D009483:Neuropsychological Tests; D010396:Penicillamine / Q000627:therapeutic use*; D012008:Recurrence
chemical_list: D003300:Copper; D010396:Penicillamine