[The relationship of intraacinar pulmonary arterial structural remodelling with pulmonary hypertension].
Pulmonary hypertension (PHT) was induced in rats by a single subcutaneous injection of monocrotaline (MCT). Light and electron microscopy, immunohistochemistry and morphometry were applied to investigate the different pathological changes of the intraacinar pulmonary arteries (IAPA) and their relationship with PHT. The results showed that pulmonary function was related to the morphological structure and indicated that the remodelling in the IAPA structure was the pathological basis of PHT. The results further suggested that the proliferation and myoid differentiation of the pericyte play an important role in the muscularization of the nonmuscular pulmonary artery in IAPA.
Wu
Y
Y
Department of Pathology, Tongji Medical University, Wuhan.
Che
D
D
Zhang
W
W
D000818:Animals; D005260:Female; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000473:pathology*; D007091:Image Processing, Computer-Assisted; D016686:Monocrotaline; D011650:Pulmonary Alveoli / Q000098:blood supply; D011651:Pulmonary Artery / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D016686:Monocrotaline