RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.
Three novel 36-membered macrolide antibiotics, RS-22A, B and C produced by Streptomyces violaceusniger have been isolated. These antibiotics were purified from an acetone extract of the mycelia followed by butanol extraction, centrifugal partition chromatography and HPLC. RS-22A, B, C showed antimicrobial activity against fungi and Gram-positive bacteria.
Ubukata
M
M
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Shiraishi
N
N
Kobinata
K
K
Kudo
T
T
Yamaguchi
I
I
Osada
H
H
Shen
Y C
YC
Isono
K
K
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002498:Centrifugation; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D018942:Macrolides; D015394:Molecular Structure; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C093977:RS 22A; C093978:RS 22B; C093979:RS 22C