Effects of low-fat milk and fermented low-fat milk on cholesterol absorption and excretion in ileostomy subjects.
OBJECTIVE
To study small bowel cholesterol absorption and sterol excretion in order to explain possible serum cholesterol-lowering mechanisms of low-fat milk products.


METHODS
Two 24-h sterol balance studies with 1 litre of low-fat milk or one litre of fermented milk, in random order, added to a controlled diet. [3H]Cholesterol absorption was measured during each period. The results were compared to those on two 24-h periods with isocaloric amounts of lemonade given to the same basic diet, before and after the study. One litre of the two milk products was also consumed in addition to their normal diets in a cross-over design of 3 weeks and with run-in and run-out periods of 2 weeks each with 1000 ml of lemonade preceding the balance studies:


METHODS
Outpatient clinic, where the subjects were eating their meals during the day and ileostomy bags collected.


METHODS
Nine ileostomy subjects, who have earlier participated in similar studies, volunteered for the study. All subjects completed the study.


RESULTS
Cholesterol absorption was highest (66%) in the lemonade period, intermediate in the low-fat milk period (61%) and lowest in the fermented low-fat period (55%) (P < 0.05 for differences). Net cholesterol excretion (excretion minus intake) and calculated endogenous cholesterol excretion were significantly (P < 0.05 for differences) higher in the low-fat milk period than in the lemonade period and the fermented low-fat milk period. No significant change in serum cholesterol was, however, seen after 3 weeks on each milk regimen.


CONCLUSIONS
Assimilation of cholesterol by microorganisms could possibly explain the reduced uptake of cholesterol with fermented milk. The mechanism behind the increased endogenous cholesterol excretion, induced by low-fat milk, is unclear.
Andersson
H
H
Department of Internal Medicine, Göteborg University, Sweden.
Bosaeus
I
I
Ellegård
L
L
Grahn
E
E
Tidehag
P
P
Hallmans
G
G
Holm
S
S
Sandberg
A S
AS
D000328:Adult; D000368:Aged; D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D018592:Cross-Over Studies; D004032:Diet; D004041:Dietary Fats; D005243:Feces / Q000737:chemistry; D005260:Female; D005285:Fermentation; D006801:Humans; D007081:Ileostomy; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D008892:Milk; D013261:Sterols / Q000378:metabolism
D004041:Dietary Fats; D013261:Sterols; D002784:Cholesterol