Fluctuations in autonomic nervous activity during sleep displayed by power spectrum analysis of heart rate variability.
OBJECTIVE
The use of an efficient noninvasive method to investigate the autonomic nervous system and cardiovascular control during sleep.


BACKGROUND
Beat-to-beat heart rate variability displays two main components: a low-frequency (LF) one representing sympathetic and parasympathetic influence and a high-frequency (HF) component of parasympathetic origin. Sympathovagal balance can be defined as LF/HF ratio.


METHODS
We reviewed normal, standardly staged all-night polysomnograms from 10 healthy children aged 6 to 17 years. Recorded 256-second traces of heart rate and respiration were sampled. Power spectra of instantaneous heart rate and respiration were computed using a fast Fourier transform method.


RESULTS
The study revealed a decrease in LF during sleep, with minimal values during non-REM slow-wave sleep and elevated levels similar to those of wakefulness during REM. HF increased with sleep onset, reaching maximal values during slow-wave sleep, and behaved as a mirror image of LF. LF/HF ratio displayed changes similar to those in LF.


CONCLUSIONS
The sympathetic predominance that characterizes wakefulness decreases during non-REM sleep, is minimal in slow-wave sleep, and surges toward mean awake levels during REM sleep. The autonomic balance is shifted toward parasympathetic predominance during slow-wave sleep. This noninvasive method used to outline autonomic activity achieves results that are in complete agreement with those obtained with direct invasive tools.
Baharav
A
A
Department of Pediatric Pulmonary Medicine, Saint Louis University Health Sciences Center, MO, USA.
Kotagal
S
S
Gibbons
V
V
Rubin
B K
BK
Pratt
G
G
Karin
J
J
Akselrod
S
S
D000293:Adolescent; D001341:Autonomic Nervous System / Q000502:physiology*; D002648:Child; D005583:Fourier Analysis; D006339:Heart Rate; D006801:Humans; D012815:Signal Processing, Computer-Assisted; D012890:Sleep / Q000502:physiology*