title: Modification of the circadian variation of symptom onset of acute myocardial infarction in diabetes mellitus.
abstract: BACKGROUND
  The effects of diabetes mellitus and its treatment on the circadian variation of symptom onset in acute myocardial infarction were examined.
  
  
  METHODS
  We obtained the time of symptom onset in 336 patients who had suffered acute myocardial infarction.
  
  
  RESULTS
  As in earlier studies, the peak of symptom onset occurred in the late morning, between 6:01 a.m. and 12:00 noon. Although a similar circadian variation was observed in non-diabetic patients, the late-morning peak was less prominent in diabetic patients. In diabetic patients receiving treatment, however, the circadian pattern was well preserved, whereas in untreated diabetic patients there were no peaks in the distribution of symptom onset of acute myocardial infarction.
  
  
  CONCLUSIONS
  These findings suggest that autonomic disturbances in diabetes mellitus may blunt the late-morning peak in the frequency of onset of acute myocardial infarction.
authors.affiliation: Takeda Hospital, College of Medical Technology, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Fudo
authors.forename: S
authors.initials: S
authors.lastname: Tamaki
authors.forename: R
authors.initials: R
authors.lastname: Nohara
authors.forename: S
authors.initials: S
authors.lastname: Sasayama
mesh_terms: D000368:Aged; D002940:Circadian Rhythm; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis