title: Inhibitory motor seizures: correlation with centroparietal structural and functional abnormalities.
abstract: Six adults and 2 children with focal inhibitory motor seizures (ictal paralysis) were evaluated during a 4-year period. Paresthesias at seizure onset occurred during some seizures in all patients, and focal clonic activity followed paralysis in 4. EEG-CCTV recordings of the seizures in 2 patients showed that ictal paralysis coincided with an ictal discharge starting in one centroparietal area. MRI showed centroparietal structural lesions in six patients. One patient with a normal MRI scan had right centroparietal hypometabolism on PET. Inhibitory motor seizures must be differentiated from transient ischemic attacks and migraine. In our patients a centroparietal epileptogenic focus was suggested by neuroimaging studies, and in 2 instances by ictal EEG.
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA.
authors.forename: B
authors.initials: B
authors.lastname: Abou-Khalil
authors.forename: T
authors.initials: T
authors.lastname: Fakhoury
authors.forename: M
authors.initials: M
authors.lastname: Jennings
authors.forename: P
authors.initials: P
authors.lastname: Moots
authors.forename: J
authors.initials: J
authors.lastname: Warner
authors.forename: R M
authors.initials: RM
authors.lastname: Kessler
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004734:Energy Metabolism / Q000502:physiology; D004829:Epilepsy, Generalized / Q000473:pathology / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000503:physiopathology; D006429:Hemiplegia / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008068:Lipomatosis / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009433:Neural Inhibition / Q000502:physiology*; D010243:Paralysis / Q000473:pathology / Q000503:physiopathology*; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology*; D014055:Tomography, Emission-Computed; D014741:Video Recording