[Changes in the sensitivity of leukocytes to the inhibiting effect of CO2 on their generation of active forms of oxygen in bronchial asthma patients].
30 bronchial asthma (BA) patients and 15 donors were exposed to 8.3% and 20.8% CO2 to bring out leukocytes sensitivity to CO2 by generation of active oxygen (AO) in bronchial asthma. CO2 effects on leukocyte AO generation were defined by luminol-dependent chemiluminescence (CL) before and after the exposure to CO2. It was found that in healthy subjects 8.3% and 20.8% CO2 noticeably inhibits leukocyte CL. However, in 70% of asthmatics with BA exacerbation leukocyte sensitivity to CO2 inhibition diminished. This was normal in 30% of BA patients. With BA aggravation, leukocyte sensitivity to CO2 tended to a decrease. Remission brought a complete or partial recovery of the above sensitivity. Thus, on the one hand, CO2 is involved in BA pathogenesis in terms of its inhibitory effect on AO generation by leukocytes; on the other hand, only in 30% of BA patients high CO2 concentrations as a treatment may be justified.
Daniliak
I G
IG
Kogan
A Kh
AKh
Sumarokov
A V
AV
Bolevich
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood*; D001782:Blood Donors; D002245:Carbon Dioxide / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*
D002245:Carbon Dioxide; D008165:Luminol; D010100:Oxygen
Izmenenie chuvstvitel'nosti leĭkotsitov k ingibiruiushchemu vliianiiu CO2 na generatsiiu imi aktivnykh form kisloroda u bol'nykh bronkhial'noĭ astmoĭ.