title: Intercellular signaling. A kinase for cell-fate determination?
abstract: GSK-3, a ubiquitous kinase regulated by tyrosine phosphorylation, controls cell-fate decisions in both Drosophila and Dictyostelium; genetic analysis of its interactions with other signaling pathways is now possible.
authors.affiliation: Department of Biology, University of California, San Diego, La Jolla 92093-0634, USA.
authors.forename: C
authors.initials: C
authors.lastname: Briscoe
authors.forename: R A
authors.initials: RA
authors.lastname: Firtel
mesh_terms: D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004023:Dictyostelium / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D004789:Enzyme Activation; D038362:Glycogen Synthase Kinase 3; D008954:Models, Biological; D008961:Models, Structural; D010766:Phosphorylation; D017433:Protein Structure, Secondary; D011953:Receptors, Cyclic AMP / Q000502:physiology; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism
chemical_list: D011953:Receptors, Cyclic AMP; D014443:Tyrosine; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3