[Experimental techniques for developing new drugs acting on dementia (9)--Brain ischemia models].
Many brain ischemia models have so far been developed and used for investigating the pathophysiology of ischemic stroke. Among these stroke models, gerbil models of brain ischemia have been widely used because of several advantages such as easy operability and convenience. In the present paper, we first discuss several subjects related to the use of animal models of brain ischemia for the development of new therapeutic agents against vascular dementia, and the theoretical, technical and clinical implications of gerbil models of brain ischemia have been outlined. Secondly, we describe the detailed procedures for obtaining forebrain ischemia or four different grades of unilateral cerebral ischemia in Mongolian gerbils. The advantages and drawbacks of these models are also discussed and compared with other models for investigation of the pathophysiology of vascular dementia.
Matsumoto
M
M
First Department of Medicine, Osaka University School of Medicine, Suita, Japan.
Kamada
T
T
Yanagihara
T
T
D000818:Animals; D002545:Brain Ischemia; D002339:Carotid Arteries; D015140:Dementia, Vascular; D004195:Disease Models, Animal; D005849:Gerbillinae; D008026:Ligation