Ultrastructural evaluation of neuronal damages induced by low doses of quinolinic acid in dissociated hippocampal culture.
The effect of a subtoxic level of quinolinic acid (QUIN) on the morphological picture of the rat hippocampus in dissociated cultures was investigated. Addition of 50 microM of QUIN to the culture medium induced only slight advanced and reversible changes of the postsynaptic elements, whereas the majority of pyramidal neurons were undamaged. The results suggest that subtoxic concentration of QUIN is insufficient to produce stable depolarization of cell membranes and severe neuronal damage.
Matyja
E
E
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Szmielew
A
A
Khaspekov
L
L
Victorov
I
I
D000818:Animals; D046508:Culture Techniques; D003712:Dendrites / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000196:embryology / Q000648:ultrastructure*; D051379:Mice; D009410:Nerve Degeneration; D017966:Pyramidal Cells / Q000187:drug effects / Q000648:ultrastructure; D017378:Quinolinic Acid / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects
D017378:Quinolinic Acid