title: In vivo effect of omeprazole on HLA-DR expression and the monocyte-macrophage function in patients with duodenal ulcer disease.
abstract: It is not known if omeprazole possesses any action on immune system. Therefore, we examined the effect of omeprazole on parameters of cellular immunity [T-cell subsets-CD3+, CD4+, CD(8+)- and HLA-DR expression on peripheral blood lymphocytes (PBLs)] and on function of peripheral blood monocyte-macrophages (PBMMs) [random migration (RM), directed migration (DM), phagocytosis index (P-I) and HLA-DR expression] in 13 duodenal ulcer patients before and during 3-mo omeprazole treatment. The number of T-cell subsets varied at pretreatment values (p > 0.05), whereas the percentage of HLA-DR positive PBLs increased significantly after 3-mo therapy (p < 0.001). On the other hand, all studied parameters concerning PBMMs (RM, DM, P-I and HLA-DR expression) increased significantly after 3-mo therapy (p < 0.001, p < 0.001, p < 0.003, p < 0.001, respectively vs. baseline values). In conclusion, omeprazole exerts an immunopotentiating effect on functions of PBMMs and may also influence T-cell function. These effects can be considered as an advantage of omeprazole in long-term treated patients with peptic ulcer disease.
authors.affiliation: 2nd Medical Department, Aristotelian University, Thessaloniki, Greece.
authors.forename: J
authors.initials: J
authors.lastname: Kountouras
authors.forename: P
authors.initials: P
authors.lastname: Boura
authors.forename: G
authors.initials: G
authors.lastname: Apostolides
authors.forename: E
authors.initials: E
authors.lastname: Zaharioudaki
authors.forename: G
authors.initials: G
authors.lastname: Tsapas
mesh_terms: D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects; D009853:Omeprazole / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D016176:T-Lymphocyte Subsets / Q000187:drug effects
chemical_list: D006684:HLA-DR Antigens; D009853:Omeprazole