Observations on therapeutic effects of huangdan decoction and Tripterygium Wilfordii compound tablet on membranous glomerulonephritis in rats.
The model of membranous glomerulonephritis (MGN) in rats was successfully established using self-made cationic bovine serum albumin (C-BSA) and treated with Huangdan Decoction (HDD) and Tripterygium Wilfordii Co. tablet (TW). Results indicated that the levels of urinary protein, blood urea nitrogen (BUN) and serum creatinine (Scr) in treated groups (groups A, B and C) were significantly decreased as compared with the control group (group D) (P < 0.01). By light and electron microscope and immunofluorescent technique, the damage to kidney in groups A, B and C was found much milder than that in group D with lesion in group A being slightest. These findings suggest that HDD and TW may alleviate the pathological lesions of MGN, prevent or retard its progression, and have remarkable therapeutic effects on MGN.
Zheng
J F
JF
Department of Traditional Chinese Medicine, Xiehe Hospital, Tongji Medical University, Wuhan.
Chen
S Y
SY
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine; D029757:Tripterygium
D004365:Drugs, Chinese Herbal; D012710:Serum Albumin, Bovine