Clinical heterogeneity of silent-gene b-thalassemia among Indians.
This paper describes six Indian families in which silent-gene beta-thalassemia was encountered by us in the past 2 years. This stresses the importance of globin-chain synthesis in the diagnosis of beta-thalassemia. Of these six cases, five were diagnosed retrospectively when they had a homozygous beta-thalassemia offspring. The beta/alpha synthetic ratios ranged from 0.45 to 0.60. Four belong to group-I silent beta-thalassemia and two cases to group II. The severity of thalassemia major in the offspring of these silent carriers cannot be predicted.
Nadkarni
A
A
Institute of Immunohematology (ICMR), Kem Hospital Campus, Parel, Bombay, India.
Pawar
A
A
Mudera
V C
VC
Mohanty
D
D
Colah
R
R
D000328:Adult; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D044465:White People / Q000235:genetics; D017086:beta-Thalassemia / Q000097:blood / Q000453:epidemiology / Q000235:genetics*