beta-Amyloid protein induces platelet aggregation and supports platelet adhesion.
The amyloid precursor protein (APP) is found in many cells including neurons, endothelial cells and blood platelets. Beta-amyloid protein (beta AP) is derived from APP and is deposited in brain and in cerebral microvasculature of individuals with Alzheimer's disease. In this study we demonstrate that beta AP interacts with human blood platelets. We found that human beta AP peptide (1-40) fibrils aggregate platelets and support their adhesion, and these interactions are mediated through platelet membrane integrin receptors.
Kowalska
M A
MA
Department of Physiology, Temple University School of Medicine, Philadelphia, Pa. 19140.
Badellino
K
K
D000544:Alzheimer Disease / Q000209:etiology; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology; D001665:Binding Sites; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D046911:Macromolecular Substances; D008562:Membrane Glycoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology; D010973:Platelet Adhesiveness / Q000187:drug effects* / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D011485:Protein Binding; D013927:Thrombosis / Q000209:etiology; D019699:Thrombospondins
D016229:Amyloid beta-Peptides; D046911:Macromolecular Substances; D008562:Membrane Glycoproteins; D009842:Oligopeptides; D010446:Peptide Fragments; D010980:Platelet Membrane Glycoproteins; D019699:Thrombospondins; C084358:amyloid beta-protein (1-28); C078592:amyloid beta-protein (1-40); C047981:arginyl-glycyl-aspartic acid; D005340:Fibrinogen