title: Successful therapy for cerebral phaeohyphomycosis due to Dactylaria gallopava in a liver transplant recipient.
abstract: A 68-year-old liver transplant recipient who was being treated with FK 506 and immunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.
authors: Department of Anesthesiology, University of Pittsburgh Medical Center, Pennsylvania.
authors: R B
authors: RB
authors: Vukmir
authors: S
authors: S
authors: Kusne
authors: P
authors: P
authors: Linden
authors: W
authors: W
authors: Pasculle
authors: A W
authors: AW
authors: Fothergill
authors: J
authors: J
authors: Sheaffer
authors: J
authors: J
authors: Nieto
authors: R
authors: R
authors: Segal
authors: H
authors: H
authors: Merhav
authors: A J
authors: AJ
authors: Martinez
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001922:Brain Abscess / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy; D017964:Itraconazole / Q000627:therapeutic use; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D003904:Mitosporic Fungi / Q000302:isolation & purification*; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
chemical_list: D017964:Itraconazole; D000666:Amphotericin B