title: Circadian variations of atrial natriuretic peptide in normal people and its relationship to arterial blood pressure, plasma renin activity and aldosterone level.
abstract: To investigate the circadian variations of plasma atrial natriuretic peptide (ANP) and its relationship to arterial blood pressure, plasma renin activity and aldosterone level, we determined 24-h blood pressure in 14 healthy volunteers. Plasma ANP concentration, renin activity and aldosterone levels were measured every 3 h by radioimmunoassay. We found no significant circadian variation of plasma ANP level (pg/ml) (daytime level, 62 +/- 24 vs. nighttime level, 57 +/- 19, P = 0.146) and plasma renin level (ng/ml/h) (1.32 +/- 0.78 vs. 1.15 +/- 0.57, P = 0.148), but there was diurnal change of blood pressure (mmHg) (systolic, 122 +/- 7 vs. 116 +/- 11, P < 0.001; diastolic, 80 +/- 11 vs. 72 +/- 11, P = 0.025) and plasma aldosterone level (pg/ml) (86 +/- 42 vs. 62 +/- 37, P < 0.001). The blood pressure and aldosterone levels reached maxima (11:00 h and 08:00 h, respectively) before that of ANP (17:00 h) and then decreased together until the nadir at 02:00 h. This might indicate that elevation of arterial blood pressure and plasma aldosterone level stimulate release of ANP under normal physiological conditions.
authors: Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, ROC.
authors: F T
authors: FT
authors: Chiang
authors: C D
authors: CD
authors: Tseng
authors: K L
authors: KL
authors: Hsu
authors: H M
authors: HM
authors: Lo
authors: Y Z
authors: YZ
authors: Tseng
authors: P S
authors: PS
authors: Hsieh
authors: T L
authors: TL
authors: Wu
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin