Influence of estrogen on cholesterol esterification and fatty acid composition in serum lipoproteins of castrated rats.
Total, free and esterified cholesterol and its fatty acid composition were measured in the serum lipoproteins of castrated rats after estradiol administration. In general, castration and treatment with estradiol led to a decrease in total esterified cholesterol content. However, estradiol induced an effect opposite to that of castration on the fatty acid composition in VLDL. The effects were variable in HDL and insignificant in LDL. Similarly, the ratios of essential fatty acid to non-essential fatty acid (EFA/NEFA) and that to monoenoic acid (EFA/ME) were affected differently in castration and estradiol treatment in VLDL, but not in HDL or LDL. The pattern of lipid metabolism in castrated and estradiol-treated rats thus appears opposite to that described in human pathology.
Cinci
G
G
Institute of Biochemistry and Enzymology, University of Siena, Italy.
Pizzichini
M
M
Arezzini
L
L
Pandolfi
M L
ML
Leoncini
R
R
Terzuoli
L
L
Vannoni
D
D
Pagani
R
R
D000818:Animals; D002788:Cholesterol Esters / Q000378:metabolism*; D004967:Estrogens / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D017208:Rats, Wistar
D002788:Cholesterol Esters; D004967:Estrogens; D005227:Fatty Acids; D008074:Lipoproteins