Unicortical critical size defect of rabbit tibia is larger than 8 mm.
The critical-size defect is important as an experimental model to test bone repair materials. Guided tissue regeneration is an established method for tissue regeneration within periodontal surgery. Bony defects covered by a membrane are allowed to be filled by bony tissue. Healing of 8-mm unicortical trephine defects was tested in Copenhagen White rabbit tibia using 3 different membranes. The critical-size defect in Copenhagen White rabbit tibia is larger than 8 mm, because control defects 8 mm in diameter healed spontaneously. However, it is anatomically not possible to create defects larger than 8 mm in an adult Copenhagen White rabbit tibia.
Aaboe
M
M
Department of Oral & Maxillofacial Surgery, School of Dentistry, Faculty of Health Science, University of Copenhagen, Denmark.
Pinholt
E M
EM
Hjørting-Hansen
E
E
D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D004195:Disease Models, Animal; D048091:Guided Tissue Regeneration; D008297:Male; D011817:Rabbits; D013977:Tibia / Q000503:physiopathology; D014945:Wound Healing