Thyroid hormone treatment alters phospholipid composition and membrane fluidity of rat brain mitochondria.
We examined effects of graded doses of thyroid hormones 3,3', 5-tri-iodo-L-thyronine (T3) and L-thyroxine (T4) on the lipid composition of rat brain mitochondria. Neither hormone significantly affected the mitochondrial cholesterol or total phospholipid content, but did increase phosphatidylethanolamine (PE) at the expense of phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC). The phosphatidic acid (PA) content was also elevated, suggesting enhanced phospholipid turnover. Changes in sphingomyelin (SPM) and diphosphatidylglycerol (DPG) were minimal. Mitochondrial membrane fluidity also increased after thyroid-hormone treatment, and the increase was closely correlated with PC/PE and SPM/PE molar ratios.
Bangur
C S
CS
Department of Biochemistry, Faculty of Science, M.S. University of Baroda, India.
Howland
J L
JL
Katyare
S S
SS
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005454:Fluorescence Polarization; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D010743:Phospholipids; D014284:Triiodothyronine; D002784:Cholesterol; D013974:Thyroxine