Pharmacokinetics of paeonol after intravenous administration in rats.
A simple high-performance liquid chromatography methodology was developed to study the pharmacokinetics of paeonol in the rat after intravenous (iv) bolus administration of various doses (2.5, 5, or 10 mg/kg). The pharmacokinetics of paeonol in rat plasma at each dose were well described by a two-compartment model. The area under the curve increased proportionally with dose and consequently total body clearance was independent of dose. There was no dose-related difference in the elimination half-life or volume of distribution. These results indicate that the pharmacokinetics of paeonol after iv administration are linear over the 2.5-10 mg/kg dose range.
Tsai
T H
TH
National Research Institute of Chinese Medicine, Taipei, Taiwan.
Chou
C J
CJ
Chen
C F
CF
D000098:Acetophenones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D051381:Rats; D017207:Rats, Sprague-Dawley; D013056:Spectrophotometry, Ultraviolet
D000098:Acetophenones; C013638:paeonol