Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro.
Marked differences in the abilities of living and heat-killed Brucella abortus and Listeria monocytogenes organisms to induce production of tumor necrosis factor alpha by in vitro-cultured macrophages were observed. Interleukin-1 and interleukin-6 appeared to be under different control. The results are discussed in relation to the induction of gamma interferon-producing Th1 cells and acquired cellular resistance to infection by living vaccines but not killed vaccines.
Zhan
Y
Y
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
Cheers
C
C
D000818:Animals; D001422:Bacterial Adhesion; D002003:Brucella abortus / Q000276:immunology*; D007375:Interleukin-1 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis*; D008089:Listeria monocytogenes / Q000276:immunology*; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha