[The clinical estimate of adiposity is not a good predictor of insulin tissue sensitivity measured with a minimal model analysis].
Fifteen male volunteers, aged 30 to 40 years old, were classified according to body mass index (BMI) as lean (n = 5, BMI less than 20 kg/m2), normal (n = 5, BMI 20-25) or obese (n = 5, BMI over 30). Glucose intolerance was ruled out by a normal oral glucose tolerance test and insulin sensitivity (SI) and glucose effectiveness (SG) were estimated by a minimal model analysis of a frequently sampled intravenous glucose tolerance test modified by an intravenous insulin injection at minute 20. The MINMOD program was fed with 29 or 12 values (reduced sampling schedule). Despite a significant inverse correlation between BMI and SI (r = -0.533 p < 0.05), the latter parameter overlapped among groups and the correlation was lost when obese individuals were not considered. Waist/hip ratio correlated modestly with SI (r = -0.52 p < 0.05). SG did not correlate with BMI. Using the reduced sampling schedule. SI values had a correlation coefficient of 0.78 with those calculated using the usual sampling schedule, although they were 82% lower. We conclude that only a BMI of over 30 accurately predicts a low SI, and that waist/hip ratio does not have a better predictive power.
Contreras
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Departamento de Medicina, Facultad de Medicina, Universidad de Chile Hospital José Joaquín Aguirre, Santiago de Chile.
Zura
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ML
Aguirre
C
C
Sepúlveda
A
A
Depix
M
M
Mella
I
I
D000328:Adult; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D015992:Body Mass Index; D005951:Glucose Tolerance Test; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin
La estimación clínica de la adiposidad no es un buen predictor de la sensibilidad tisular a la insulina medida con un anaĺisis de modelo mínimo.