title: Hairy cell leukemia: results of 2-chlorodeoxyadenosine therapy in Jerusalem.
abstract: Since the introduction of adenosine deaminase analogues the vast majority of patients with Hairy cell leukemia obtain lasting complete remission. In this report we describe our experience with 2 CdA in 18 patients with Hairy cell leukemia (HCL). Ten of these had failed previous interferon therapy, 6 were splenectomized before and of these, 4 had also received interferon. Sixteen of the 18 patients receiving 2 CdA achieved complete remission (CR), 1 patient is in good partial response (GPR) and 1 patient has relapsed. These results are in keeping with those reported from other larger centers and confirm the efficacy of 2-CdA. In this report IL-2 receptor (sIL-2R) levels were performed in most of the patients and found to be an accurate indicator of disease activity. Mean levels prior to therapy were 17200 U/ml (+/- 2500) and after successful therapy 970 U/ml (+/- 160). We confirm that 2-CdA treatment is the treatment of choice in HCL and suggest that sIL-2 levels be used as a parameter of disease activity.
authors: Department of Hematology, Hadassah University Hospital, Hebrew University Medical School, Jerusalem, Israel.
authors: E J
authors: EJ
authors: Dann
authors: S
authors: S
authors: Gillis
authors: E A
authors: EA
authors: Rachmilewitz
authors: V
authors: V
authors: Barak
authors: Y
authors: Y
authors: Cass
authors: R
authors: R
authors: Ruchlemer
authors: A
authors: A
authors: Polliack
mesh_terms: D000328:Adult; D017338:Cladribine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007557:Israel; D007943:Leukemia, Hairy Cell / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D017338:Cladribine