Aspartyl alpha-((diphenylphosphinyl)oxy)methyl ketones as novel inhibitors of interleukin-1 beta converting enzyme. Utility of the diphenylphosphinic acid leaving group for the inhibition of cysteine proteases.
Dolle
R E
RE
Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania 19426.
Singh
J
J
Whipple
D
D
Osifo
I K
IK
Speier
G
G
Graybill
T L
TL
Gregory
J S
JS
Harris
A L
AL
Helaszek
C T
CT
Miller
R E
RE
D001224:Aspartic Acid / Q000737:chemistry / Q000494:pharmacology*; D002154:Calpain / Q000037:antagonists & inhibitors; D020170:Caspase 1; D002401:Cathepsin B / Q000037:antagonists & inhibitors; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D015853:Cysteine Proteinase Inhibitors; D007659:Ketones; D001224:Aspartic Acid; D002154:Calpain; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D020170:Caspase 1