title: Physiology and pathology of islet metabolism.
abstract: This review reevaluates the possible roles of glut-2 underexpression, glucokinase gene mutation, glucose-6-phosphate hyperactivity, glycerophosphate dehydrogenase (FAD-linked) deficiency and glycogen accumulation in the pancreatic B-cell as contributive factors in the pathogenesis of Type 2 diabetes.
authors: Laboratory of Experimental Medicine, Brussels Free University, Erasmus Medical School, Belgium.
authors: W J
authors: WJ
authors: Malaisse
mesh_terms: D000818:Animals; D005941:Glucokinase / Q000235:genetics; D051273:Glucose Transporter Type 2; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology; D009004:Monosaccharide Transport Proteins / Q000096:biosynthesis; D009154:Mutation
chemical_list: D051273:Glucose Transporter Type 2; D005958:Glucosephosphates; D009004:Monosaccharide Transport Proteins; D019298:Glucose-6-Phosphate; D006003:Glycogen; D005993:Glycerolphosphate Dehydrogenase; D005941:Glucokinase