title: The effect of space and parabolic flight on macrophage hematopoiesis and function.
abstract: We used weak electric fields to monitor macrophage spreading in microgravity. Using this technique, we demonstrated that bone marrow-derived macrophages responded to microgravity within 8 s. We also showed that microgravity differentially altered two processes associated with bone marrow-derived macrophage development. Spaceflight enhanced cellular proliferation and inhibited differentiation. These data indicate that the space/microgravity environment significantly affects macrophages.
authors: Division of Biology, Kansas State University, Manhattan 66506-4901.
authors: J W
authors: JW
authors: Armstrong
authors: R A
authors: RA
authors: Gerren
authors: S K
authors: SK
authors: Chapes
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000096:biosynthesis; D001853:Bone Marrow / Q000276:immunology*; D002448:Cell Adhesion; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement; D037502:Galectin 3; D006410:Hematopoiesis / Q000187:drug effects; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D007376:Interleukin-2 / Q000494:pharmacology; D015850:Interleukin-6 / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000502:physiology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013026:Space Flight; D013696:Temperature; D014893:Weightlessness
chemical_list: D000943:Antigens, Differentiation; D037502:Galectin 3; D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2; D015850:Interleukin-6