Effects of chronic dietary aluminum on local cerebral glucose utilization in rats.
Beginning at 4 weeks of age normal, male, Sprague-Dawley rats were reared on Purina Laboratory Chow and drinking water containing 100 microM AlCl3. After 2 years, local rates of cerebral glucose utilization were determined with the autoradiographic [14C] deoxyglucose method in the brain as a whole and in 25 brain regions in 6 treated rats and 4 age-matched controls. The results indicate that any effects of chronic aluminum in the diet on rates of cerebral glucose utilization are small. In the brain as a whole, the mean rate of glucose utilization in the aluminum-treated rats was 6% lower than that of the controls (p = 0.09). In 21 of the 25 brain regions examined mean rates of glucose utilization were generally lower in the aluminum-treated rats but in none of the region were the effects statistically significant.
Clauberg
M
M
Department of Biochemistry, University of Tennessee, Knoxville 37996-0840.
Smith
C B
CB
Dang
T
T
Sokoloff
L
L
Joshi
J G
JG
D000375:Aging / Q000378:metabolism*; D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry / Q000187:drug effects*; D002849:Chromatography, Gas; D003847:Deoxyglucose / Q000378:metabolism; D004032:Diet; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D003847:Deoxyglucose; D000535:Aluminum; D005947:Glucose