Miniglucagon production from glucagon: an extracellular processing of a hormone used as a prohormone.
Glucagon is secondarily processed into its C-terminal (19-29) fragment, referred to as 'miniglucagon', which modulates the glucagon action. This extracellular processing, occurring at the level of of the glucagon target cells, is due to the presence at the cell surface of a new 100-kDa processing enzyme with characteristics of both thiol- and metalloprotease.
Blache
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INSERM U 376, CCIPE, Montpellier, France.
Kervran
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Le-Nguyen
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Bataille
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D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D005260:Female; D005934:Glucagon / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008666:Metalloendopeptidases / Q000378:metabolism*; D008954:Models, Biological; D009928:Organ Specificity; D010446:Peptide Fragments / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D051381:Rats
D010446:Peptide Fragments; C039265:glucagon (19-29); D005934:Glucagon; D003546:Cysteine Endopeptidases; D008666:Metalloendopeptidases