title: Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma: an immunohistochemical study on 109 Italian patients.
abstract: The overexpression of p53 protein and the Ki67 proliferative index was evaluated in 96 hepatocellular carcinomas (HCC), 67 in cirrhotic livers and 29 in non-cirrhotic ones, and in 13 non-carcinomatous lesions, all surgically resected from Italian patients. Overexpression of p53 was detected only in carcinomatous lesions, and was significantly related to the grade of HCC (P < 0.001). In fact, p53 was observed in 7/7 (100%) cases of grade IV, 13/43 (30.3%) of grade III, and 10/46 (21.7%) of grade II. The relationship between p53 and Ki67 scores was determined in serial sections from corresponding areas of both diffuse and patchy immunoreactivity. In the overall population, p53-positive tumors showed a significantly higher Ki67 score (15.9 +/- 5.5% vs 9.2 +/- 4.3% [P < 0.001]). This observation was evident in all grades of HCC.
authors: Department of Histopathology, Bologna University, Italy.
authors: A
authors: A
authors: D'Errico
authors: W F
authors: WF
authors: Grigioni
authors: M
authors: M
authors: Fiorentino
authors: P
authors: P
authors: Baccarini
authors: G L
authors: GL
authors: Grazi
authors: A M
authors: AM
authors: Mancini
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000737:chemistry* / Q000473:pathology; D002455:Cell Division / Q000502:physiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen; D008113:Liver Neoplasms / Q000737:chemistry* / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53