[Pulmonary capacity and volume, forced expiratory flow measured by whole body plethysmography in acute pancreatitis: experimental study in rats].
Up to 70% of the patients with acute pancreatitis suffer a sort of pulmonary dysfunction. Twenty-nine rats with pancreatitis induced by 2.5% taurocholic and solution have been studied by whole body plethysmography in order to evaluate pulmonary volumes and expiratory flows. They were divided into three groups: a sham operation control group-10 rats,a two pancreatitis group-10 rats and eight hours pancreatitis group-9 rats. The results showed a significant decrease of expiratory reserve volumes and forced vital capacity (FVC) and also a significant increase of expiratory flow in the 2 and 8 hours pancreatitis groups. These findings indicate a restrictive pneumopathy.
Chaib
E
E
Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo.
Saldiva
P H
PH
Criado
P M
PM
Sakae
R S
RS
Machado
M C
MC
D000208:Acute Disease; D000704:Analysis of Variance; D000818:Animals; D016022:Case-Control Studies; D005540:Forced Expiratory Flow Rates; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced / Q000503:physiopathology*; D010993:Plethysmography, Whole Body; D012123:Pulmonary Ventilation; D051381:Rats; D017208:Rats, Wistar; D013147:Spirometry; D013656:Taurocholic Acid; D014109:Total Lung Capacity
D013656:Taurocholic Acid
Volumes e capacidades pulmonares, fluxos expiratórios forçados, estudados com pletismografia de corpo inteiro na pancreatite aguda: estudo experimental em ratos.