Role of naproxen as anti-oxidant in selenite cataract.
Naproxen, a nonsteroidal anti-inflammatory drug has been evaluated for its anticataract action in the prevention of cataracts induced by selenite. Administration of a single dose of sodium selenite intraperitoneally resulted in the development of advanced cataracts in 100% of the eyes within 5-6 days. Treatment with naproxen resulted in showing a significant preventive effect. The biochemical parameters like glutathione, malonaldehyde or soluble and insoluble protein contents indicate that selenite causes cataract due to oxidative stress. The observations also suggest that naproxen acts as an anti-oxidant.
Gupta
S K
SK
Dr. Rajendra Prasad Centre for Ophthalmology, All India Institute of Medical Sciences, New Delhi.
Joshi
S
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002386:Cataract / Q000139:chemically induced / Q000517:prevention & control*; D003459:Crystallins / Q000032:analysis; D004195:Disease Models, Animal; D005260:Female; D005978:Glutathione / Q000032:analysis; D007274:Injections, Intraperitoneal; D007908:Lens, Crystalline / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009288:Naproxen / Q000494:pharmacology*; D009929:Organ Size; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite
D000975:Antioxidants; D003459:Crystallins; D008315:Malondialdehyde; D009288:Naproxen; D005978:Glutathione; D018038:Sodium Selenite