[Second malignancy in patients with Hodgkin disease in full remission. Interim results].
Among 345 patients with Hodgkin's disease (HD) in full remission and followed for a mean of 7.2 years (11 months-26 years) since the initial diagnosis, 33 were found to have a second malignancy. The cumulative incidence after 10 years was 13.5%, after 15 years 21%. Non-Hodgkin lymphoma was the most frequent (n = 7), followed by bronchial carcinoma (n = 5) and acute myeloid leukaemia (n = 3). There was a definitely increased risk in elder patients (P < 0.001) and in those who had had a splenectomy. There was no demonstrable effect of type of therapy, primary stage and frequency of recurrence. It is concluded that patients with Hodgkin's disease should have life-long oncological follow-up. This preliminary study is being extended into a multicentre investigation of a larger number of patients.
Munker
R
R
Medizinische Klinik III, Universität, München.
Schmidt
M
M
Christel
K
K
Hölzel
D
D
Hiller
E
E
D000328:Adult; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000453:epidemiology; D010865:Pilot Projects; D012074:Remission Induction; D012307:Risk Factors; D013997:Time Factors
Sekundäre Malignome bei Patienten mit Morbus Hodgkin in Vollremission. Eine Zuischenbilanz.