A diagnostic quartet in leptomeningeal infiltration of the optic nerve sheath.
A rare case of optic leptomeningeal carcinomatosis secondary to a rectal adenocarcinoma is recorded. The presentation of rectal disease with blindness is unique. A diagnostic quartet of symptoms and signs of leptomeningeal infiltration of the optic nerve sheath is proposed and its value emphasized by the inability of further investigation to confirm the clinical diagnosis. The investigation and treatment of leptomeningeal carcinomatosis is reviewed.
McFadzean
R
R
Department of Neuro-ophthalmology, Tennent Institute, University of Glasgow, Scotland.
Brosnahan
D
D
Doyle
D
D
Going
J
J
Hadley
D
D
Lee
W
W
D000230:Adenocarcinoma / Q000556:secondary*; D000328:Adult; D001766:Blindness / Q000175:diagnosis; D003390:Cranial Nerve Neoplasms / Q000556:secondary*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D009186:Myelin Sheath / Q000473:pathology; D009901:Optic Nerve Diseases / Q000473:pathology*; D011681:Pupil Disorders / Q000175:diagnosis; D011859:Radiography; D012004:Rectal Neoplasms / Q000473:pathology; D013346:Subarachnoid Space