title: [In vitro antibacterial activity of a new fluoroquinolone, fleroxacin, against hospital bacteria and regression curve].
abstract: Minimal inhibitory concentrations (MICs) of fleroxacin (FLE) were determined by agar dilution for 1261 bacterial strains isolated in 1992 in 4 university hospitals; in addition, antibiograms by agar diffusion were performed with 5 micrograms disks. Activity of FLE against nalidixic acid (NAL) susceptible (S) Enterobacteriaceae was close to that of other fluoroquinolones (FQ) (MIC 50 and 90: 0.12-0.25 micrograms/ml); like for other FQ, this activity was reduced against NAL intermediate and resistant (R) Enterobacteriaceae (4-32). MICs of FLE against P. aeruginosa were between 1 and 128 (8-128). FLE had also a good activity against NAL-S A. baumannii (0.12-0.5) but this activity is reduced against NAL-R Acinetobacter (64-128). FLE was highly active against Haemophilus (0.06-0.12), Gonococci (0.03-0.25), Meningococci (0.016-0.03) and B. catarrhalis (0.12-0.25). FLE showed activity close to the currently available FQ against methicillin susceptible Staphylococci (0.25-1); the resistant strains (32- > 128) are usually methicillin resistant. FLE is less effective against Enterococci (4-128), Streptococci (8-16) and Pneumococci (4-8). The coefficient correlation of the regression curve is 0.93; for MIC breakpoints of 1 and 4 micrograms/ml, zone diameter breakpoints should be 20 and 15 mm.
authors: Service de Bactériologie, Hôpital Henri-Mondor, Créteil, France.
authors: C J
authors: CJ
authors: Soussy
authors: M
authors: M
authors: Cluzel
authors: E
authors: E
authors: Derlot
authors: M D
authors: MD
authors: Kitzis
authors: M
authors: M
authors: Meyran
mesh_terms: D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000187:drug effects*; D016576:Fleroxacin / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006757:Hospital Units; D066298:In Vitro Techniques
chemical_list: D016576:Fleroxacin
vernacular_title: Activité antibactérienne in vitro d'une nouvelle fluoroquinolone, la fléroxacine, sur les bactéries hospitalières et courbe de concordance.