An association between successful vaccination against the bovine nodular worm, Oesophagostomum radiatum and induction of eosinophilia.
Immunization of 48 cattle with somatic antigen extracts of the nodular worm, Oesophagostomum radiatum, reduced faecal egg counts (FEC) by 51% and worm burden by 47%. The antibody titre of each animal was correlated to both worm burden (r = -0.40, P < 0.005) and FEC (r = -0.37, P < 0.01). The vaccinated cattle showed wide variation in their response to vaccination with worm burdens after challenge infection varying from 0 to 4060. Of these 48 vaccinated animals, eight developed sterile immunity (worm burden = 0, FEC = 0) whereas a further 10 had no protective response to immunization (worm burden > 1,000, FEC > 100). A comparison of these two sub-groups showed that the group with sterile immunity had a higher antibody titre (P < 0.05). In addition, the group with sterile immunity developed a blood eosinophilia between 21 and 29 days after challenge infection. Vaccinated, unprotected calves and control, unvaccinated calves did not develop eosinophilia.
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IJ
CSIRO Division of Tropical Animal Production, Long Pocket Laboratories, Indooroopilly, Queensland, Australia.
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D004802:Eosinophilia / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D008297:Male; D009814:Oesophagostomiasis / Q000150:complications / Q000276:immunology / Q000469:parasitology / Q000628:therapy / Q000662:veterinary*; D009815:Oesophagostomum / Q000276:immunology* / Q000302:isolation & purification; D010270:Parasite Egg Count / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary*
D000947:Antigens, Helminth