title: Gonadotrophin-independent precocious puberty and dyschondrosteosis.
abstract: We present a case of gonadotrophin-independent precocious puberty, as seen in McCune-Albright syndrome, and Leri-Weill dyschondrosteosis in a six and a half year-old girl. Her father also reports having early puberty and is similarly affected with dyschondrosteosis. This combination of features has not been reported previously, and represents the association of a skeletal dysplasia with an endocrinopathy.
authors: Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, UK.
authors: L
authors: L
authors: Patel
authors: P E
authors: PE
authors: Clayton
authors: M
authors: M
authors: Super
authors: D A
authors: DA
authors: Price
mesh_terms: D001848:Bone Diseases, Developmental / Q000150:complications* / Q000175:diagnosis; D002648:Child; D017373:Cyproterone Acetate / Q000627:therapeutic use; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic; D006801:Humans; D011629:Puberty, Precocious / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D017373:Cyproterone Acetate