title: Excretion of 3-hydroxy-diflunisal as a monosulphate conjugate--identification using ESI-MS.
abstract: Electrospray-ionization mass spectrometry was used to identify a novel, highly polar metabolite of diflunisal isolated from Gunn rat urine. Negative ion spectra were obtained of the sulphate conjugate of diflunisal and the new metabolite, which was identified as a sulphate conjugate of 3-hydroxydiflunisal.
authors: Department of Medicine, University of Queensland, Royal Brisbane Hospital, Australia.
authors: R G
authors: RG
authors: Dickinson
authors: A R
authors: AR
authors: King
authors: M A
authors: MA
authors: Kelly
authors: I A
authors: IA
authors: Kaltashov
authors: C
authors: C
authors: Fenselau
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004061:Diflunisal / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism* / Q000652:urine; D013058:Mass Spectrometry / Q000379:methods; D051381:Rats; D011911:Rats, Gunn; D013431:Sulfates / Q000378:metabolism
chemical_list: D013431:Sulfates; C091289:3-hydroxydiflunisal; D004061:Diflunisal