7-OH-DPAT produces place conditioning in rats.
The rewarding properties of the putative dopamine D3 receptor-selective agonist, 7-OH-DPAT ((+/-)-2-dipropylamino-7-hydroxy-1,2,3,4- tetrahydronaphthalene hydrobromide), were investigated using a place conditioning paradigm consisting of three phases: preconditioning (three undrugged exposures to an apparatus consisting of two visually distinct compartments); conditioning (four pairings of one compartment with drug); and test (one undrugged exposure to the same apparatus). Rats received either saline, amphetamine (2.0 mg/kg), or 7-OH-DPAT (0.5, 2.0 or 5.0 mg/kg) during conditioning. Amphetamine and 7-OH-DPAT produced a place preference.
Mallet
P E
PE
Department of Psychology, Queen's University, Kingston, Ontario, Canada.
Beninger
R J
RJ
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D018491:Dopamine Agonists / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D018491:Dopamine Agonists; C493595:Drd3 protein, rat; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; D000661:Amphetamine; C031349:7-hydroxy-2-N,N-dipropylaminotetralin