title: [Neuropathology of 20 centenarians. I. Clinical data].
abstract: We report a clinical study of 20 patients aged more than 100 years, and deceased in Charles Foix Hospital, Ivry/Seine, France, where they had stayed for 10 days to 16 years (mean: 3.3 years, median: 4 years). Each of them was studied neuropathologically (the results of this study will be published later on). The case selection excluded only those patients whose neuropathological study could not be complete. The prevalence of sensorial deficits was high: 15/20 patients had deterioration of hearing, 8 of them were deaf; 14/20 patients had deterioration of sight, 4 of them were blind. Motor deficits were numerous: 15 patients were not ambulatory. The patients were classified as demented or not, according to the criteria of the DSMIII R (American Psychiatric Association 1987), on the basis of a retrospective evaluation of clinical records, and of an inquiry among the caring staff. Their mental status was also evaluated by the Global Deterioration Scale of Reisberg et al (1985). Five patients had been demented, four had been intellectually normal, and 11 had suffered from mild disturbances of memory or cognitive functions. This series was not representative of the general population of centenarians, but probably of those institutionalized in France. We observed a low proportion of demented patients despite the prevalence expected from epidemiological studies. This is difficult to interpret. The low proportion of dementia in this small sample is not due to the short duration of the course of diseases responsible for dementia.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Laboratoire de Neuropathologie Raymond Escourolle, INSERM U 360, Hôpital de la Salpêtrière, Paris.
authors: G
authors: G
authors: Fayet
authors: J J
authors: JJ
authors: Hauw
authors: P
authors: P
authors: Delaère
authors: Y
authors: Y
authors: He
authors: C
authors: C
authors: Duyckaerts
authors: H
authors: H
authors: Beck
authors: F
authors: F
authors: Forette
authors: C
authors: C
authors: Gallinari
authors: M
authors: M
authors: Laurent
authors: R
authors: R
authors: Moulias
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006311:Hearing Disorders / Q000453:epidemiology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology; D016743:Mental Competency; D012189:Retrospective Studies; D012494:Sampling Studies; D014786:Vision Disorders / Q000453:epidemiology
vernacular_title: Neuropathologie de 20 centenaires. I. Données cliniques.