Motion sickness in mice and conditioned taste aversion.
Forty-eight male mice in 6 groups were studied. Conditioned taste aversion (CTA) in mice was produced by various motions including cross-coupled acceleration, rotation to two directions (with or without visual field) and linear acceleration. Deprived of water for 24 hours, the mice were exposed to motion immediately after drinking a novel solution, 0.15% saccharin. All groups received two pairings of CTA training related to motion. The results showed that both of cross-coupled and rotation produced frank CTA and former was far more obvious than the latter. In addition, motion with visual field had a trend to intensify sickness response.
Wang
Z
Z
Department of Aviation, Fourth Military Medical University, Xian.
Liu
L
L
Jiang
B
B
D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D008297:Male; D051379:Mice; D009041:Motion Sickness; D011897:Random Allocation; D013649:Taste; D014794:Visual Fields