[The problem of a high content of vitamin A in the liver of calves, cattle, sheep and swine for the consumer. Amount of accumulation and mechanism of teratogenic effect (review article)].
Cases of hypervitaminosis A in men--especially in pregnant women, with development of malformations--are reported. The existence of withdrawal times to slaughter after the application of vitamin-A-containing preparations with a content of 10,000 to 10(6) international units and more is described. The content of vitamin A in the liver of monogastric animals is closely related to that in the feed. In ruminants about 40 to 70% of the vitamin A of the feed is decomposed by the microorganisms in the forestomachs. The amount of vitamin A stored in the liver after a therapeutic application is dependent of the initial content. The velocity of the depletion of the stores at a carotene- and vitamin-A-poor feeding is described. In ruminants and pigs in the account of the properties of the placenta no embryotoxicity of a therapeutic dose of vitamin A is to be expected. The mechanism of the teratogenesis by vitamin A in mice is described.
Kolb
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Veterinär-Physiologisch-Chemisches Institut, Universität Leipzig.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D002417:Cattle; D004350:Drug Residues / Q000009:adverse effects / Q000032:analysis; D005260:Female; D006801:Humans; D006986:Hypervitaminosis A / Q000209:etiology*; D008099:Liver / Q000737:chemistry*; D008460:Meat / Q000009:adverse effects*; D051379:Mice; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D012756:Sheep; D013552:Swine; D014801:Vitamin A / Q000009:adverse effects / Q000032:analysis*
D014801:Vitamin A
Probleme eines hohen Gehalts an Vitamin A in der Leber von Kälbern, Rindern, Schafen und Schweinen für den Verbraucher. Umfang der Speicherung und teratogener Wirkungsmechanismus (Ubersichtsreferat).