Genomic organization and DNA sequence of the human catecholamine-sulfating phenol sulfotransferase gene (STM).
The human monoamine neurotransmitter-preferring phenol sulfotransferase (M-PST) plays an essential role in the sulfation of catecholamines, such as dopamine. The cDNA encoding M-PST has been reported, and we have recently identified cosmid clones from human chromosome 16p11.2 for this gene, STM. Plasmid subclones derived from the STM cosmid clones were subjected to dideoxynucleotide chain termination sequencing to determine the genomic organization and DNA sequence of STM. The gene encoding full-length STM is approximately 6.4 kb and contains 8 exons and 7 introns.
Dooley
T P
TP
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228.
Probst
P
P
Munroe
P B
PB
Mole
S E
SE
Liu
Z
Z
Doggett
N A
NA
D000818:Animals; D015239:Arylsulfotransferase / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D003001:Cloning, Molecular; D003360:Cosmids; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D017931:DNA Primers; D018076:DNA, Complementary; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping
D017931:DNA Primers; D018076:DNA, Complementary; D004247:DNA; D015239:Arylsulfotransferase