title: Occupation and the risk of malignant melanoma.
abstract: BACKGROUND
  The incidence of malignant melanoma is increasing rapidly. The risk for development of malignant melanoma has been reported to be higher in persons of higher socioeconomic status.
  
  
  METHODS
  This case-control study explores the relation between occupation and malignant melanoma relative risk through analysis of data collected by the American Cancer Society. A total of 1.2 million people were enrolled in a study of lifestyles and environmental factors in relation to mortality from cancer and other diseases. A total of 2780 persons had a history of malignant melanoma when the study began or developed malignant melanoma during the 6-year study follow-up period. The controls were matched for age, sex, race, and geographic location on an approximately 1:3 basis to persons selected from the remaining people enrolled.
  
  
  RESULTS
  In men, malignant melanoma risk was significantly higher in high-paying versus low-paying occupations (odds ratio [OR], = 1.58; P < 0.001) and in white-collar versus blue-collar occupations (OR = 1.33; P < 0.001). No significant conclusions could be drawn for women. No significant difference in risk was noted between those with indoor versus outdoor occupations. Among specific occupational exposures, only exposure to X-rays significantly raised malignant melanoma risk (OR = 1.37; P = 0.002).
  
  
  CONCLUSIONS
  Upper pay scale and white-collar occupations significantly increase the risk for development of malignant melanoma.
authors: Ronald O. Perelman Department of Dermatology, New York University (NYU) School of Medicine.
authors: I A
authors: IA
authors: Pion
authors: D S
authors: DS
authors: Rigel
authors: L
authors: L
authors: Garfinkel
authors: M K
authors: MK
authors: Silverman
authors: A W
authors: AW
authors: Kopf
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007182:Income; D008019:Life Style; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D008875:Middle Aged; D009790:Occupations; D016017:Odds Ratio; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology*; D012923:Social Class; D014481:United States / Q000453:epidemiology