[Concentration of amoxicillin in neonates after infusion to the mother during labor].
Amoxicillin is effective against S. agalactiae (MIC 50 = 0.03 mg/l). Neonatal prophylaxis of GBS infection had already been studied but very few data are available regarding pharmacokinetic of these antibiotics. In this study, 58 pregnant women with GBS colonisation and/or with epidemiologic risk factors received intrapartum antibiotic infusion at the beginning of the labor (1 g amoxicillin every 6 hours until the delivery). At delivery, cord blood and gastric fluid were taken in delay from 0.5 to 6 hours after the beginning of the infusion. Dosages were done in triplicate with a microbiological method using Bacillus subtilis ATCC 6633 as test strain. In cord blood amoxicillin appeared as early as the first half hour. Concentration were from 5 to 7 mg/l between 1 hour and 4 hours after the beginning of the infusion, and from 3 to 4 mg/l after 4 hours. In gastric fluid, concentrations obtained were over 1 mg/l after 1.5 hour and over 3 mg/l after 2.5 hours with good efficiency even after the sixth hour. The protocol using a slow intrapartum amoxicillin infusion (1 g) gave concentrations in gastric fluid and cord blood over S. agalactiae MIC.
Delclève
S
S
Service de Bactériologie-Virologie, CHU Dupuytren, Limoges, France.
Mounier
M
M
Renaudie
J
J
Brosset
P
P
Baudet
J
J
Denis
F
F
D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000032:analysis* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005315:Fetal Diseases / Q000382:microbiology / Q000517:prevention & control; D005750:Gastric Juice / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007743:Labor, Obstetric; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D011247:Pregnancy; D013290:Streptococcal Infections / Q000382:microbiology / Q000517:prevention & control* / Q000635:transmission; D013292:Streptococcus agalactiae / Q000302:isolation & purification*
D000658:Amoxicillin
Concentration d'amoxicilline chez le nouveau-né après perfusion de la mère durant le travail.