[Monitoring of malignant gynecologic tumors using the immune response to lactate dehydrogenase virus antigens].
The cell mediated immunity was examined by the leukocyte adherence inhibition (LAI) test in 21 patients with CIN III and 146 patients with invasive gynaecologic malignancies before treatment and at 3-month intervals. Our own LDV antigen and organ specific antigens were used. The test was highly specific (95.1%) in comparison with a control group of healthy blood donors. The sensitivity of the test was lower (64.7-86.8%). There was no correlation with the development of disease (remission or relapse). The test in a two-year investigation does not seem suitable for monitoring of disease. Depending the nature of LDV infection, only a longer investigation extending over more years would enable further conclusions.
Freitag
P
P
II. gynek.-porod. klinika, 1. LF UK, Praha.
Jandová
A
A
Macků
J
J
Bendová
M
M
Nedbalová
M
M
D000956:Antigens, Viral / Q000276:immunology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007772:Lactate dehydrogenase-elevating virus / Q000276:immunology*; D007957:Leukocyte Adherence Inhibition Test; D012680:Sensitivity and Specificity
D000956:Antigens, Viral
Monitorování gynekologických maligních nádorů imunitní odpovĕdí na LDH virový antigen.