title: Dentine tubule infection and endodontic therapy implications.
abstract: A critical review of the literature suggests that the microenvironment of dentinal tubules appears to favour the selection of relatively few bacterial types irrespective of the aetiology of the infection process; coronal dental caries or pulpar necrosis. These bacteria may constitute an important reservoir from which root canal infection and reinfection may occur following pulp necrosis or during and after endodontic treatment. Previous studies of this microflora have utilized microbiological culture techniques which need to be supplemented by those that allow in situ demonstration as well as identification of the bacteria. Newer treatment strategies that are designed to eliminate this microflora must include agents that can penetrate the dentinal tubules and destroy these microorganisms, since they are located in an area beyond the host defence mechanisms where they cannot be reached by systemically administered antimicrobial agents.
authors: Department of Endodontics, University of Florida, College of Dentistry, Gainesville 32610-0436.
authors: B R
authors: BR
authors: Oguntebi
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D003790:Dental Pulp Necrosis / Q000150:complications*; D003804:Dentin / Q000382:microbiology* / Q000648:ultrastructure; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006095:Gram-Positive Cocci / Q000187:drug effects / Q000302:isolation & purification; D016987:Gram-Positive Rods / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D010485:Periapical Periodontitis / Q000382:microbiology* / Q000517:prevention & control; D012008:Recurrence; D012388:Root Canal Irrigants / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D012388:Root Canal Irrigants