[Prospective validation of PMN-elastase as a prognostic parameter in the surgical intensive care unit].
The study presented investigates prospectively the clinical value of the PMN-elastase as a sequel parameter in 954 patients of a surgical intensive care unit. The elastase-values measured discriminate highly significant between patients with and without complications (p < 0.001) as well as between survivors and non-survivors (p < 0.001). Furthermore in patients underlying shock-phases in the course of treatment significantly higher elastase values are measured as in the patients remaining (p < 0.001). The highest prognostic evidence is determined by the elastase at the 9th day of course of disease concerning the prediction of a patient's death (sensitivity 78%, specificity 75%, positive predictive value 63%, respectively negative predictive value 87%).
Windolf
J
J
Unfallchirurgische Klinik, Johann-Wolfgang-Goethe-Universität Frankfurt am Main.
Oremek
G
G
Inglis
R
R
Zega
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003422:Critical Care; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000175:diagnosis* / Q000201:enzymology / Q000401:mortality; D009504:Neutrophils / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012772:Shock, Septic / Q000175:diagnosis* / Q000201:enzymology / Q000401:mortality; D013530:Surgical Wound Infection / Q000175:diagnosis* / Q000201:enzymology / Q000401:mortality; D015996:Survival Rate
D015415:Biomarkers; D010196:Pancreatic Elastase
Prospektive Validierung der PMN-Elastase als Verlaufs-parameter auf der Chirurgischen Intensivstation.