Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720).
The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization with Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.
Scalzo
A A
AA
Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
Elliott
S L
SL
Cox
J
J
Gardner
J
J
Moss
D J
DJ
Suhrbier
A
A
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D018146:Muromegalovirus / Q000276:immunology*; D009842:Oligopeptides / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000956:Antigens, Viral; D009842:Oligopeptides; D013745:Tetanus Toxoid; D014765:Viral Vaccines