Plasma beta-thromboglobulin and platelet factor 4 are not increased in insulin-dependent diabetic patients with microalbuminuria.
To evaluate the possibility that platelet dysfunctions contribute to the cardiovascular risk of microalbuminuric insulin-dependent diabetic (IDD) patients, we have measured beta-thromboglobulin (BTG) and platelet factor 4 (PF4) in 74 IDD patients with different degrees of albuminuria (8 macro-, 36 micro- and 30 normoalbuminuric) and in 30 non-diabetic control subjects. BTG values (20.4 +/- 1.5 SEM in normo-, 22.2 +/- 1.2 in micro-, 101.1 +/- 2.9 in macroalbuminuric patients and 21.8 +/- 1.1 IU/ml in control subjects) were significantly higher (P < 0.001) in the macroalbuminuric patients, but similar among the other groups. These results suggest that platelet hyperactivation is not present in the microalbuminuric stage of diabetic nephropathy, only in overt nephropathy.
Gruden
G
G
Institute of Internal Medicine, University of Turin, Italy.
Cavallo-Perin
P
P
Romagnoli
R
R
Ruiu
G
G
Pagano
G
G
D000328:Adult; D000419:Albuminuria; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology / Q000652:urine; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D010978:Platelet Factor 4 / Q000032:analysis*; D012016:Reference Values; D014280:Triglycerides / Q000097:blood; D001620:beta-Thromboglobulin / Q000032:analysis*
D002784:Cholesterol; D003404:Creatinine; D006442:Glycated Hemoglobin; D010978:Platelet Factor 4; D014280:Triglycerides; D001620:beta-Thromboglobulin