The effects of chronic treatment with N-tert-butyl-alpha-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats.
We examined if a 2 week treatment with the spin trapping agent N-tert-butyl-alpha-phenylnitrone (PBN) would alleviate age-related deficits in cerebellar noradrenergic function of male 21-22 month old F344 rats compared to age-matched controls. Noradrenergic receptor function of PBN-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with PBN may reverse age-related deficits in cerebellar noradrenergic receptor function.
Gould
T J
TJ
Veterans Administration Medical Center, Denver, CO.
Bickford
P C
PC
D000375:Aging / Q000502:physiology*; D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D003497:Cyclic N-Oxides; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009589:Nitrogen Oxides / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology*; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D012016:Reference Values; D013113:Spin Labels; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D003497:Cyclic N-Oxides; D009589:Nitrogen Oxides; D013113:Spin Labels; C029217:phenyl-N-tert-butylnitrone; D005680:gamma-Aminobutyric Acid; D007545:Isoproterenol; D009638:Norepinephrine