Successful therapy for cerebral phaeohyphomycosis due to Dactylaria gallopava in a liver transplant recipient.
A 68-year-old liver transplant recipient who was being treated with FK 506 and immunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.
Vukmir
R B
RB
Department of Anesthesiology, University of Pittsburgh Medical Center, Pennsylvania.
Kusne
S
S
Linden
P
P
Pasculle
W
W
Fothergill
A W
AW
Sheaffer
J
J
Nieto
J
J
Segal
R
R
Merhav
H
H
Martinez
A J
AJ
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001922:Brain Abscess / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy; D017964:Itraconazole / Q000627:therapeutic use; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D003904:Mitosporic Fungi / Q000302:isolation & purification*; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
D017964:Itraconazole; D000666:Amphotericin B