Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins.
Equations (1) through (8) provide a general mathematical model of combined pulsatile and basal effector molecule secretion, distribution, association, dissociation, and metabolic removal. Independent and interactive dynamics of multiple effector molecules and multiple distinct acceptor/transport proteins can be modeled explicity to test relevant hypotheses of ligand binding and clearance.
Veldhuis
J D
JD
Department of Medicine, University of Virginia Health Sciences Center, Charlottesville 22903.
Faunt
L M
LM
Johnson
M L
ML
D002352:Carrier Proteins / Q000097:blood*; D013006:Growth Hormone / Q000097:blood* / Q000378:metabolism; D006207:Half-Life; D006728:Hormones / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008024:Ligands; D008962:Models, Theoretical; D012984:Software; D013997:Time Factors
D002352:Carrier Proteins; D006728:Hormones; D008024:Ligands; D013006:Growth Hormone; C051815:somatotropin-binding protein