title: [Delay of the formation of retroperitoneal fibrosis after lymphadenectomy. An experimental study].
abstract: The goal of our study was to evaluate peritoneal and retroperitoneal healing and therefore to assess the optimal date for surgery after laparoscopic lymphadenectomy. A para-aortic lymphadenectomy was carried out in 5 groups of 5 New Zealand female rabbits. The perivascular cicatricial tissue was dissected after specific delay for each group (48 hours, 1 week, 2 weeks, 4 weeks, and 6 weeks). Peritoneal reconstruction was observed in 80% of the "48 h" group, and in 100% in the other groups (from 1 to 6 weeks). Vascular injury complicated dissection in 40% for the "1 week" group, in 80% for the "2 weeks" group, and in 20% for the "6 weeks" group. No vascular complication was observed in the "48 h" and "4 weeks" groups. The results of "1 week" and "2 weeks" were combined. The results of the "4 weeks" group were compared, with the Fisher test, to the results of a "1 week" and "2 weeks" combined group as well as to the results of the "six weeks" group. Four weeks seem to be the optimal date for a possible surgical excision after a laparoscopic lymphadenectomy.
authors: Clinique Universitaire de Gynécologie, d'Obstétrique et de Pathologie de la Reproduction, Pavillon Paul-Gelle, Roubaix.
authors: A
authors: A
authors: Elhage
authors: A
authors: A
authors: Delest
authors: N
authors: N
authors: Tordjman
authors: F
authors: F
authors: Carpentier
authors: D
authors: D
authors: Querleu
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001011:Aorta / Q000293:injuries; D002921:Cicatrix / Q000473:pathology / Q000601:surgery; D003094:Collagen; D004210:Dissection; D004487:Edema / Q000473:pathology; D005260:Female; D005355:Fibrosis; D010535:Laparoscopy / Q000009:adverse effects*; D008197:Lymph Node Excision / Q000009:adverse effects*; D010532:Peritoneal Diseases / Q000473:pathology / Q000601:surgery; D010537:Peritoneum / Q000473:pathology* / Q000601:surgery; D011817:Rabbits; D012185:Retroperitoneal Fibrosis / Q000473:pathology / Q000517:prevention & control*; D013997:Time Factors; D014945:Wound Healing
chemical_list: D003094:Collagen
vernacular_title: Délai de formation de la fibrose rétropéritonéale après lymphadénectomie. Etude expérimentale.