title: Pharmacologically active components from a Peruvian medicinal plant, huira-huira (Culcitium canescens H. & B.).
abstract: The methanol extract of Huira-Huira (Culcitium canescens) showed analgesic effects in acetic acid-induced writhing and tail pressure tests, and it also produced potent prolongation of hypnosis induced by pentobarbital. The latter activity was used as an isolation-guide to determine the active components which were identified as dehydrocacalohastine, cacalohastine and cacalonol.
authors: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors: E
authors: E
authors: Okuyama
authors: K
authors: K
authors: Umeyama
authors: S
authors: S
authors: Ohmori
authors: M
authors: M
authors: Yamazaki
authors: M
authors: M
authors: Satake
mesh_terms: D000700:Analgesics / Q000302:isolation & purification* / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D006993:Hypnotics and Sedatives / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D006993:Hypnotics and Sedatives; D009281:Naphthalenes; D010936:Plant Extracts; C091301:dehydrocacalohastine; C091300:cacalohastine; C091299:cacalonol