title: Persistent oxidative stress in cancer.
abstract: DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent normal tissue. We suggest that the concept of 'persistent oxidative stress in cancer' may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto-oncogenes, genomic instability, chemotherapy-resistance, invasion and metastasis.
authors: Department of Pathology, Faculty of Medicine, Kyoto University, Japan.
authors: S
authors: S
authors: Toyokuni
authors: K
authors: K
authors: Okamoto
authors: J
authors: J
authors: Yodoi
authors: H
authors: H
authors: Hiai
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D004273:DNA, Neoplasm / Q000737:chemistry; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000032:analysis; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D004273:DNA, Neoplasm; D017382:Reactive Oxygen Species; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine