[Method for daily administration of low-dose CDDP and 5-FU combined with radiotherapy for oral squamous cell carcinoma].
Daily administration of low-dose CDDP and 5-FU combined with radiotherapy was performed in three cases of oral squamous cell carcinoma in aged patients whose general condition was poor. One course of chemotherapy consisted of daily administration of CDDP (10 mg iv, days 1-5) and 5-FU (250-500 mg iv, days 1-5) with radiotherapy (total dose of 60-64 Gy). Two or three courses were performed at some interval. There were no severe side-effects except for mucositis. Tumors disappeared in all three cases, and a complete response was achieved in two cases. The method appeared to be safe and useful for oral squamous cell carcinoma patients of advanced age and poor general condition.
Kishimoto
K
K
Dept. of Oral and Maxillofacial Surgery II, Okayama University Dental School.
Kimura
T
T
Misaki
M
M
Yamada
Y
Y
Terakado
N
N
Matsumura
T
T
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011879:Radiotherapy Dosage; D012074:Remission Induction
D002945:Cisplatin; D005472:Fluorouracil