Human cortical neuronal (HCN) cell lines: a model for amyloid beta neurotoxicity.
Human cortical neuronal cell lines HCN-1A and HCN-2 are killed for following exposure of the differentiated cells to amyloid beta-peptide(1-40), a component of senile plaques and other amyloid deposits in brains from Alzheimer's patients. We present a model of A beta toxicity uncomplicated by the presence of other cell types that can be used to address the mechanism of A beta neurotoxicity. This model will be useful in the evaluation of neuroprotective compounds which may attenuate cortical neuronal loss in Alzheimer's disease.
Zhang
Z
Z
Department of Central Nervous System Research, Lilly Research Laboratory, Lilly Corporate Center, Indianapolis, IN 46285.
Drzewiecki
G J
GJ
Hom
J T
JT
May
P C
PC
Hyslop
P A
PA
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D015415:Biomarkers; D016923:Cell Death; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D009474:Neurons / Q000187:drug effects*; D010446:Peptide Fragments / Q000633:toxicity*
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)