On the pathogenesis of IDDM.
A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2- and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.
Nerup
J
J
Steno Diabetes Center, Gentofte, Denmark.
Mandrup-Poulsen
T
T
Helqvist
S
S
Andersen
H U
HU
Pociot
F
F
Reimers
J I
JI
Cuartero
B G
BG
Karlsen
A E
AE
Bjerre
U
U
Lorenzen
T
T
D000818:Animals; D001363:Awards and Prizes; D003718:Denmark; D003920:Diabetes Mellitus / Q000266:history; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000503:physiopathology*; D005060:Europe; D049673:History, 20th Century; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D007515:Islets of Langerhans / Q000473:pathology* / Q000503:physiopathology / Q000648:ultrastructure; D008954:Models, Biological; D009569:Nitric Oxide / Q000633:toxicity; D017472:Receptors, Interleukin-1 / Q000502:physiology; D012955:Societies, Medical; D013481:Superoxides / Q000633:toxicity
D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D013481:Superoxides; D009569:Nitric Oxide