Accumulation of platinum in the intervertebral discs and vertebrae of ovarian tumor-bearing patients treated with cisplatin.
Platinum was determined by the inductively coupled plasma mass spectrometry (ICP-MS) in the intervertebral discs and vertebrae of ovarian tumor bearing patients treated with cis-diamminedichloro-platinum (II) (cisplatin). Platinum was 0.05 ng/mL at the absolute detection limit, and platinum was undetectable in the intervertebral discs and vertebrae of human specimens without cisplatin treatments. On the other hand, platinum was detected in the intervertebral discs and vertebrae of patients administered cisplatin, and platinum concentration was at levels of 1.06-10.31 micrograms/g dry tissue in the intervertebral discs and 0.60-1.28 micrograms/g dry tissue in the vertebrae, respectively. The platinum level of intervertebral discs was 4.3-fold higher than that of the vertebrae. Thus, platinum accumulates greatly in the intervertebral discs and somewhat in the vertebrae after administering cisplatin to patients for therapy.
Minami
T
T
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Hashii
K
K
Tateyama
I
I
Kadota
E
E
Tohno
Y
Y
Tohno
S
S
Utsumi
M
M
Yamada
M O
MO
Ichii
M
M
Namikawa
K
K
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism; D002945:Cisplatin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism*; D007553:Isotope Labeling; D008159:Lumbar Vertebrae / Q000378:metabolism*; D013058:Mass Spectrometry; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010984:Platinum / Q000378:metabolism*
D010984:Platinum; D002945:Cisplatin