title: Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections.
abstract: C-reactive protein (CRP) is a well-known serum protein which increases during inflammation and deposits in damaged tissues. To establish whether CRP appears in brain of Alzheimer's disease (AD), we immunohistochemically investigated tissue sections which were pretreated with formic acid. Positive immunostaining by anti-CRP antibodies was clearly recognized in senile plaques (SP) in the pretreated tissue sections, with very weak immunostaining in non-treated sections. These findings may suggest that the formation process of SP includes an acute-phase inflammatory state.
authors: Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
authors: N
authors: N
authors: Iwamoto
authors: E
authors: E
authors: Nishiyama
authors: J
authors: J
authors: Ohwada
authors: H
authors: H
authors: Arai
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000276:immunology; D002097:C-Reactive Protein / Q000032:analysis* / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005557:Formaldehyde; D005561:Formates / Q000494:pharmacology*; D005625:Frontal Lobe / Q000737:chemistry* / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007249:Inflammation; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000276:immunology; D013048:Specimen Handling; D016707:Tissue Fixation
chemical_list: D000911:Antibodies, Monoclonal; D005561:Formates; D009419:Nerve Tissue Proteins; C030544:formic acid; D005557:Formaldehyde; D002097:C-Reactive Protein