Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans.
As part of a community-based study of Alzheimer's disease (AD) in the African-American population age 65 and over, we have determined apolipoprotein E (Apo E) genotypes in 85 subjects (31 AD patients and 54 controls). The epsilon 4 allele of Apo E was strongly associated with AD in this population sample. The epsilon 4 allele frequency in AD patients was 40.3% compared with 13.9% in the control group, and 22.6% of the AD patients were homozygous for this allele compared with 3.7% of the control subjects (p = 0.01). This study extends the association of Apo E-epsilon 4 and AD to nonwhite populations and provides further evidence that the observed allelic association is biologically relevant.
Hendrie
H C
HC
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202-5111.
Hall
K S
KS
Hui
S
S
Unverzagt
F W
FW
Yu
C E
CE
Lahiri
D K
DK
Sahota
A
A
Farlow
M
M
Musick
B
B
Class
C A
CA
D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D004247:DNA / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015994:Incidence; D007196:Indiana / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012044:Regression Analysis
D001057:Apolipoproteins E; D004247:DNA