Behavioural effects of two cholecystokinin analogues: JMV 236 and JMV 179.
The behavioural effects of two cholecystokinin analogues Boc-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 (JMV 236), a potent CCK agonist, and Boc-Tyr(SO3H)-Nle-Gly-DTrp-Nle-Asp-2-Phenylethylester (JMV 179), a CCK antagonist were studied. JMV 236 (3.125, 12.5 and 50 micrograms/kg i.p.) dose-dependently decreased the exploratory activity of rats, the effect being significant for horizontal activity (ambulation) at doses of 12.5 and 50 micrograms/kg and for vertical activity (rearing) at a dose of 50 micrograms/kg. JMV 179 (3.125, 12.5 and 50 micrograms/kg i.p.) did not change the horizontal activity but dose-dependently decreased the vertical activity, the effect being significant at a dose of 50 micrograms/kg. JMV 236 administered immediately after training significantly facilitated short-term memory in passive avoidance situation but only tended to increase the mean latency upon retention testing on the 7th day. JMV 179 tended to increase the latency of the passive avoidance response upon retention testing at the 24th hour but not on the 7th day after training.
Hadjiivanova
C
C
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Petkov
V V
VV
Kehayov
R
R
Martinez
J
J
D000595:Amino Acid Sequence; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012054:Reinforcement, Psychology; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology
D010446:Peptide Fragments; D011949:Receptors, Cholecystokinin; C062315:JMV 236; C070096:JMV 179; D002766:Cholecystokinin; D012844:Sincalide