title: Low-dose cyclosporin A and Tripterygium wilfordii inhibited porcine intestinal allograft rejection.
abstract: The aim of this study was to evaluate whether Tripterygium wilfordii (TW) could be used as an immunosuppressant, and whether antirejection therapy with low-dose cyclosporin A (CsA) and TW was better than the treatment with large-dose CsA alone in intestinal transplantation in pigs. 100 cm intestines were transplanted by using two-step models. Four pigs which received large-dose CsA for 100 days and then were given TW survived 251.5 +/- 181.5 days; 2 of these died of pneumonia 92 and 97 days after the operations respectively. Five pigs which received low-dose CsA and TW for 100 days, then TW was the only drug used in the survival animals, survived 243.2 +/- 90.9 days; none of these succumbed to infection. All the grafts in those which were administered with low-dose CsA were destroyed by acute rejection at 12.4 +/- 2.6 days. These results indicated that TW had some immunosuppressive effects, and antirejection treatment with low-dose CsA and TW could be considered as an acceptable therapy in small bowel transplantation.
authors: Department of General Surgery, Nanfang Hospital, Guangzhou.
authors: C X
authors: CX
authors: Liao
authors: J S
authors: JS
authors: Li
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006084:Graft Rejection / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007421:Intestine, Small / Q000637:transplantation*; D013552:Swine; D029757:Tripterygium
chemical_list: D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D016572:Cyclosporine