title: In vivo reactions of Ca,P particle containing surface reactive glasses.
abstract: Four Ca,P particle containing surface reactive glass composites and two glasses (in the SiO2-CaO-P2O5-Na2O-Al2O3-B2O3 system) were implanted in the diaphyseal area of goat femora up to 24 weeks. Scanning electron microscopic, energy dispersive x-ray, and histological analysis were performed to evaluate the material-tissue interactions. A new type of integration mechanism was observed. Instead of the bone growing to the material surface, a gel-like silica formation appeared between the cortex bone and the material surface. In time the gel-like formation was replaced by a Ca,P layer. The results provided indirect evidence that pure silica gel formed in the tissues could also achieve an apatite layer formation and bone bonding on its surface.
authors: Biomaterials Project, University of Turku, Finland.
authors: I M
authors: IM
authors: Kangasniemi
authors: K
authors: K
authors: Vähätalo
authors: R P
authors: RP
authors: Happonen
authors: A
authors: A
authors: Yli-Urpo
authors: K
authors: K
authors: de Groot
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002118:Calcium / Q000032:analysis*; D003460:Crystallization; D005260:Female; D005269:Femur; D005898:Glass / Q000737:chemistry*; D006041:Goats; D010758:Phosphorus / Q000032:analysis*; D019736:Prostheses and Implants; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D010758:Phosphorus; D002118:Calcium