title: Pulmonary deposition and clinical response of 99mTc-labelled salbutamol delivered from a novel multiple dose powder inhaler.
abstract: Pulmonary deposition of 99mTc-labelled sulbutamol was determined after delivery from a novel multiple dose powder inhaler (Easyhaler). The clinical efficacy of the inhalation powder, evaluated simultaneously with gamma camera detection, was compared with that obtained after drug delivery from a metered dose inhaler-spacer combination. The study was performed as an open, non-randomized cross-over trial. A single dose of radiolabelled inhalation powder was inhaled on the first and the inhalation aerosol, as control, on the second study day. Sulbutamol sulphate was labelled with 99mtechnetium, and the inhalation powder was formulated by mixing radioactive drug particles with carrier material. Aerodynamic properties of the radiolabelled inhalation powder were similar to those of the unlabelled salbutamol powder. Delivered dose from the breath-actuated powder inhaler was adjusted to be equal to two puffs from a conventional aerosol actuator with a short plastic mouthpiece. Twelve non-smoking asthmatic patients participated in the trial. The mean pulmonary deposition of 24% was obtained after drug delivery from Easyhaler powder inhaler. Clinical efficacy of the medications was similar in terms of area under the FEV1 curve, maximum FEV1 and the improvement ratio. Thus it can be suggested that powder delivery from Easyhaler powder inhaler and the aerosol delivery through the spacer are equally effective.
authors: Department of Pharmaceutical Technology, University of Kuopio, Finland.
authors: M
authors: M
authors: Vidgren
authors: J
authors: J
authors: Arppe
authors: P
authors: P
authors: Vidgren
authors: L
authors: L
authors: Hyvärinen
authors: P
authors: P
authors: Vainio
authors: M
authors: M
authors: Silvasti
authors: H
authors: H
authors: Tukiainen
mesh_terms: D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D011208:Powders; D013667:Technetium
chemical_list: D011208:Powders; D013667:Technetium; D000420:Albuterol