[Effects of carbacholine and noradrenaline on tissue reactions in healing of skin wounds].
In experiment on 15 rats, used as a skin wound models, it was established that under the carbachol (CC) influence the inflammatory reaction, granulation tissue development and the degree of her vascularization are intensified, and under the influence of norepinephrine (NE)--are reduced. And vice versa: the fibrillogenesis and the regenerated connective tissue resimulation processes are hold back under the CC action and are stimulated under the NE influence. On the initial stages of the wound healing CC and NE stimulate the epiderm regeneration. But while the CC application the epithelial lining of necrotized tissues then are destructed.
Grabovoĭ
A N
AN
Prosha
M V
MV
Shcherbak
L F
LF
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D006097:Granulation Tissue / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects*
D002217:Carbachol; D009638:Norepinephrine
Vliianie karbakholina i noradrenalina na tkanevye reaktsii pri zazhivlenii rany kozhi.