Depressed immune surveillance against cancer: role of deficient T cell: extracellular matrix interactions.
Although T cells infiltrate malignant tumors, the local immune response is usually inefficient and tumors escape destruction. While extracellular matrix proteins strongly costimulate T cell responses in normal individuals, our studies indicate that peripheral blood T cells from cancer patients and tumor infiltrating cells respond poorly or are resistant to stimulative signals mediated by collagen I and IV and fibronectin. Moreover, the adhesive properties of cancer T cells are markedly depressed. Those functional deficiencies are paralleled by variable deficits in integrin and non-integrin T cell receptors for extracellular matrix. Immunotherapy with BCG causes a dramatic but transient increase in T cell: ECM interactions.
Górski
A
A
Warsaw Medical School, University of Liege, Belgium.
Castronovo
V
V
Stepień-Sopniewska
B
B
Grieb
P
P
Ryba
M
M
Mrowiec
T
T
Korczak-Kowalska
G
G
Wierzbicki
P
P
Matysiak
W
W
Dybowska
B
B
D001500:BCG Vaccine / Q000627:therapeutic use; D005109:Extracellular Matrix / Q000276:immunology*; D016326:Extracellular Matrix Proteins / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*
D001500:BCG Vaccine; D016326:Extracellular Matrix Proteins