Disturbances in the production of interleukin-1 and tumor necrosis factor in disseminated murine sporotrichosis.
Production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) by adherent peritoneal cells from BALB/c mice was measured at week 2, 4, 6, 8 and 10 after intravenous inoculation with 10(6) Sporothrix schenckii yeasts. As compared with age-matched controls, IL-1 and TNF production by adherent peritoneal cells from S. schenckii-infected mice was reduced severely at week 4 and 6 of infection and greater than normal at week 8 and 10. Moreover, between week 4 and 6 of infection there was a depression of delayed type hypersensitivity response to a specific whole soluble antigen, and an increase in fungal multiplication in the livers and spleens of infected mice. Thus, the deficits of cell-mediated immunity in mice with systemic S. schenckii infection may derive, in part, from impaired amplification of the immune response consequent to abnormal generation of IL-1 and TNF.
Carlos
I Z
IZ
Department of Parasitology, Microbiology and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Zini
M M
MM
Sgarbi
D B
DB
Angluster
J
J
Alviano
C S
CS
Silva
C L
CL
D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007375:Interleukin-1 / Q000096:biosynthesis*; D008099:Liver / Q000382:microbiology; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013154:Spleen / Q000382:microbiology; D013175:Sporothrix / Q000276:immunology; D013174:Sporotrichosis / Q000276:immunology* / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000946:Antigens, Fungal; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha