title: Transient effects of quick changes in myocardial metabolism and perfusion pressure on coronary vasomotor responses.
abstract: The effects of transient changes in coronary transmural pressure on the coronary vasomotor tone were studied in 23 anesthetized dogs. Increases and decreases of the coronary transmural pressure were obtained by constrictions of various duration (2 to 20 s) of the descending thoracic aorta. The maneuvers were performed in animals with intact cardiac innervation, with the vagi sectioned and with vagal section together with beta-blockade. In the absence of beta-blockade the increase in the transmural pressure caused a transient increase in the coronary vasomotor tone attributable to a myogenic contractile response and the extravascular compression. This contractile response was not observed when the transmural pressure was increased in the presence of high vasomotor tone after beta-blockade. In all animals a transient hyperemia was seen with its peak 8 to 12 s after the release of the aortic constriction. Since its timing and amplitude were independent of the duration of the constriction, the metabolic effect of the increased ventricular afterload, although it may have contributed to the decrease of the coronary resistance, cannot be considered entirely responsible for the hyperemia, which was otherwise compatible with a myogenic vasodilatory response triggered by the sudden fall of the transmural pressure at the release of the constriction. It is concluded that, in the coronary circulation of the intact dog, transient changes in transmural pressure can induce vasomotor responses in which myogenic and metabolic mechanisms combine together in regulating the coronary flow. Changes in extravascular compression can also affect the flow when the experimental maneuver implies changes in the diastolic left ventricular pressure and volume. With the present experimental procedure the myogenic responses have been evidenced when the metabolic factors would have been expected to produce opposite changes in the vasomotor tone.
authors: Dipartimento di Anatomia e Fisiologia Umana, Universita' di Torino, Italy.
authors: D
authors: D
authors: Gattullo
authors: R J
authors: RJ
authors: Linden
authors: G
authors: G
authors: Losano
authors: P
authors: P
authors: Pagliaro
mesh_terms: D000818:Animals; D001011:Aorta; D001794:Blood Pressure; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D006339:Heart Rate; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D011312:Pressure; D014655:Vascular Resistance; D014661:Vasoconstriction; D014666:Vasomotor System / Q000502:physiology*