[A pharmacological study of the hepatoprotective activity of fructose-1,6-diphosphate].
A fructose-1,6-diphosphate preparation was tested for hepatoprotective activity through biochemical and morphologic studies in experiments on Wistar rats sustaining D-galactosamine- and paracetamole-induced hepatotoxicity. Findings indicated the modeled hepatic lesions to be readily reproducible, to simulate some characteristics of human liver pathology, and to be suitable for testing substances expected to have hepatoprotective action; intraperitoneal administration of fructose-1,6-diphosphate at a dose of 1000 mg/kg body weight proved moderately protective against liver damage by D-galactosamine; the benefit observed concerned mostly dystrophic and inflammatory changes in the liver; in a number of cases, correlation was noted between biochemical serum parameters and pathomorphologic liver alterations.
Klouchek
E
E
Markov
M
M
Popov
A
A
D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005635:Fructosediphosphates / Q000494:pharmacology*; D005688:Galactosamine / Q000633:toxicity; D007155:Immunologic Factors / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005635:Fructosediphosphates; D007155:Immunologic Factors; D000082:Acetaminophen; D005688:Galactosamine; C029063:fructose-1,6-diphosphate
Farmakologichno prouchvane za khepatoprotektivna aktivnost na fruktozo-1,6-difosfat.