The inhibitory effect of radix Salviae miltiorrhizae on hypoxic structural remodeling of intra-acinar pulmonary arteries.
The inhibitory effect of Radix Salviae Miltiorrhizae (RSM) on hypoxic structural remodeling of intra-acinar pulmonary arteries (IAPA) was observed by light and electron microscopy and morphometry. It was found that RSM can not only dilate IAPA and relieve the hypoxic injuries to endothelia cells, but also inhibit the active muscularization of IAPA in the hypoxic animals, suggesting that RSM plays a very important role in inhibiting structural remodeling of IAPA and pulmonary hypertension.
Xi
S C
SC
Department of Pathology, Tongji Medical University, Wuhan.
Che
D Y
DY
Zhang
W R
WR
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000473:pathology*; D000860:Hypoxia / Q000188:drug therapy / Q000473:pathology*; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010936:Plant Extracts; D011651:Pulmonary Artery / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts