CD30-positive lymphoma in human T-cell leukaemia virus type 1 carrier without monoclonal integration of HTLV-1.
CD30, Ki-1 antigen, an activated T-cell antigen, is a member of the nerve growth factor receptor family. This antigen is expressed on the lymphoma cells of some adult T-cell leukaemia/lymphoma (ATL/L) patients and some patients with Epstein-Barr virus infection. CD30-positive large cell cutaneous T-cell lymphomas occasionally integrate a defective HTLV-1 provirus. We describe here an HTLV-1 carrier who developed Ki-1 lymphoma with no evidence of monoclonal integration of the HTLV-1 proviral sequence.
Hori
M
M
Division of Haematology, University of Tsukuba, Ibaraki, Japan.
Mitsuhashi
S
S
Kobayashi
T
T
Nagasawa
T
T
Mori
N
N
Miwa
M
M
Abe
T
T
D015139:Blotting, Southern; D002353:Carrier State / Q000821:virology*; D015490:HTLV-I Infections / Q000150:complications*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000821:virology*; D008875:Middle Aged; D011533:Proviruses / Q000302:isolation & purification; D016662:Virus Integration