title: Immunohistochemical localization of the neuron-specific glucose transporter (GLUT3) to neuropil in adult rat brain.
abstract: The precise histologic localization of GLUT3, a glucose transporter thought to be restricted to neurons, is unknown. Using a high-affinity, specific antiserum against rodent GLUT3 for immunocytochemistry, light microscopic staining concentrates heterogeneously in the neuropil in a region- and lamina-specific manner; intense staining characterizes areas with high rates of glucose utilization such as inferior colliculus and pyriform cortex. Neuropil localization with little perikaryal staining suggests that GLUT3 may provide the energy needed locally for synaptic transmission.
authors: Department of Cell Biology, Oregon Health Sciences University, Portland.
authors: A L
authors: AL
authors: McCall
authors: A M
authors: AM
authors: Van Bueren
authors: M
authors: M
authors: Moholt-Siebert
authors: N J
authors: NJ
authors: Cherry
authors: W R
authors: WR
authors: Woodward
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D051274:Glucose Transporter Type 3; D007150:Immunohistochemistry; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D009415:Nerve Net / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D051274:Glucose Transporter Type 3; D009004:Monosaccharide Transport Proteins; D009419:Nerve Tissue Proteins; C495690:Slc2a3 protein, rat