title: Antibiotic susceptibility of streptococci isolated from blood from neutropenic patients.
abstract: MICs were performed on 62 streptococci isolated from the blood of neutropenic patients from 1986 to 1992 using the NCCLS broth microdilution procedure. Species isolated were 43 S. mitis, 6 S.pneumoniae, 5 S.sanguis, 1 S.pyogenes, 1 beta-hemolytic streptococcus of the group G, 1 S.adjacens, 1 S.intermedius, 4 not identified isolates (2 alpha-hemolytic, 1 non-hemolytic and 1 nutritionally variant strains). 26% of all strains were resistant or intermediate to penicillin (MIC 90: 2 mg/l) and 89% to norfloxacine (MIC 90: 32 mg/l). All were susceptible to vancomycin. Among cephalosporins, all strains were susceptible to cefotaxime (MIC 90: 1 mg/l), ceftriaxone (MIC 90: 1 mg/l) and cefepime (MIC 90: 2 mg/l) while 19% were R or I to ceftazidime (MIC 90: 16 mg/l). All were susceptible to imipenem (MIC 90: 0.5 mg/l) and meropenem (MIC 90: 1 mg/l). Among the third generation cephalosporins, ceftazidime--the agent of this class of antibiotics that is most often used for the empirical therapy of febrile episodes in neutropenic patients (in combination but also in monotherapy)--has a high resistance rate as compared to the other compounds.
authors: Département de Microbiologie, Hôpital Académique, V. U. B., Bruxelles, Belgique.
authors: D
authors: D
authors: Piérard
authors: A
authors: A
authors: de Meyer
authors: S
authors: S
authors: Lauwers
mesh_terms: D016470:Bacteremia / Q000382:microbiology*; D002511:Cephalosporins / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006801:Humans; D066298:In Vitro Techniques; D009503:Neutropenia / Q000097:blood / Q000382:microbiology*; D010400:Penicillin G / Q000494:pharmacology*; D010403:Penicillin Resistance; D013290:Streptococcal Infections / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects* / Q000302:isolation & purification; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D002511:Cephalosporins; D014640:Vancomycin; D010400:Penicillin G