Mannose-binding protein gene polymorphism in systemic lupus erythematosus.
OBJECTIVE
To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE).


METHODS
MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls.


RESULTS
The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3).


CONCLUSIONS
Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.
Davies
E J
EJ
Epidemiology Research Unit, University of Manchester, UK.
Snowden
N
N
Hillarby
M C
MC
Carthy
D
D
Grennan
D M
DM
Thomson
W
W
Ollier
W E
WE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D003165:Complement System Proteins / Q000172:deficiency; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D037241:Mannose-Binding Lectins; D008875:Middle Aged; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
D002352:Carrier Proteins; D037241:Mannose-Binding Lectins; D003165:Complement System Proteins