Continuous arteriovenous hemoperfusion in acute poisoning.
We have investigated the efficacy of a pumpless hemoperfusion technique, continuous arteriovenous hemoperfusion (CAVHP) in 3 cases of acute intoxications with meprobamate, theophylline and phenobarbital. Dramatic responses were noted in both hemodynamic unstable and comatous patients. With this technique, a blood flow of 120 cm3/min could be achieved in severe hypotension. Moreover, with the restoration of blood pressure, blood flow increased to 150-400 cm3/min. Our preliminary experience has shown that CAVHP allows an exceptionally high solute elimination. Hemoperfusion clearances of meprobamate, phenobarbital and theophylline were 198 +/- 5.6 cm3/min, 290.25 +/- 25.33 cm3/min and 192.79 +/- 55 cm3/min, respectively. Our present results suggest that CAVHP is a simple, safe, effective and less costly alterative of conventional hemoperfusion.
Lin
J L
JL
Division of Nephrology and Poison Center, Chang Gung Memorial Hospital, Chang Gung Medical College, Lin-Kou Medical Center, Taipei, Taiwan, ROC.
Lim
P S
PS
D000328:Adult; D000368:Aged; D001166:Arteriovenous Shunt, Surgical; D003128:Coma / Q000139:chemically induced / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006439:Hemodynamics; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D008297:Male; D008620:Meprobamate / Q000097:blood / Q000506:poisoning; D010634:Phenobarbital / Q000097:blood / Q000506:poisoning; D011041:Poisoning / Q000628:therapy*; D013406:Suicide, Attempted; D013806:Theophylline / Q000097:blood / Q000506:poisoning
D008620:Meprobamate; D013806:Theophylline; D010634:Phenobarbital