The what, why and how of hypertensive heart disease.
Left ventricular hypertrophy is now recognised to be an important risk factor associated with such adverse cardiovascular events as myocardial infarction, heart failure, stroke and sudden cardiac death. This is true for the general population and those with uncomplicated hypertension. Herein the what, why and how of hypertensive heart disease (HHD) is reviewed: what is it, why does a structural remodelling of the myocardium occur and how can it be prevented on the one hand or regressed on the other. Clinical and experimental studies are presented to address each of these issues.
Weber
K T
KT
Department of Internal Medicine, University of Missouri Health Sciences Centre, Columbia 65212.
D005355:Fibrosis; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D009206:Myocardium / Q000473:pathology; D012084:Renin-Angiotensin System