title: Penetration of cefotetan into suction skin blister fluid and tissue homogenates in patients undergoing abdominal surgery.
abstract: The penetration of cefotetan (2-g intravenous bolus) into the suction blister fluid and tissue homogenates of 11 patients was investigated. Mean concentrations in tissue were significantly lower than contemporary suction blister fluid levels. These data show that the determination of beta-lactam concentrations by the tissue homogenate method may seriously underestimate the actual antibiotic levels in extracellular fluid.
authors: Department of Pharmacology, University of Florence, Italy.
authors: T
authors: T
authors: Mazzei
authors: F
authors: F
authors: Tonelli
authors: A
authors: A
authors: Novelli
authors: F
authors: F
authors: Ficari
authors: C
authors: C
authors: Mazzoni
authors: A
authors: A
authors: Anastasi
authors: P
authors: P
authors: Periti
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D001768:Blister / Q000209:etiology / Q000378:metabolism*; D015313:Cefotetan / Q000493:pharmacokinetics*; D003106:Colon / Q000378:metabolism / Q000601:surgery; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000601:surgery; D012867:Skin / Q000378:metabolism; D013396:Suction; D014018:Tissue Distribution
chemical_list: D015313:Cefotetan