title: [The characteristics of the anticonflict action of fenazepam in rats selected by the method of forced swimming].
abstract: A method of classification of outbred albino rats by means of forced swimming in a tank filled with water and equipped by freely turning wheels was developed. Using this technique a population of albino rats can be divided into three groups: highly active (HA), low active (LA) animals, and rats with intermediate activity. HA animals exhibit stable behaviour in forced swimming and conflict situation paradigms. They are also more sensitive to a benzodiazepine anxiolytic phenazepam in conflict situation test. At the same time, LA rats decrease their activity and are less sensitive to phenazepam. Both groups (LA and HA) are not homogeneous: each of them includes animals demonstrating quite another type of behaviour compared with a majority of rats.
authors: S B
authors: SB
authors: Seredenin
authors: T A
authors: TA
authors: Voronina
authors: E B
authors: EB
authors: Burlakova
authors: G M
authors: GM
authors: Molodavkin
authors: L I
authors: LI
authors: Cherniavskaia
authors: N I
authors: NI
authors: Khorseva
authors: A L
authors: AL
authors: Mdzinarishvili
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D016009:Chi-Square Distribution; D003220:Conflict, Psychological; D004558:Electric Stimulation; D008297:Male; D010146:Pain / Q000503:physiopathology; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012641:Selection, Genetic; D013550:Swimming / Q000502:physiology; D014868:Water Deprivation / Q000502:physiology
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
vernacular_title: Osobennosti antikonfliktnogo deĭstviia fenazepama u krys, otobrannykh s pomoshch'iu metoda vynuzhdennogo plavaniia.