title: Effects of systemic or oral ad libitum monosodium glutamate administration on striatal glutamate release, as measured using microdialysis in freely moving rats.
abstract: We examined effects of high doses of monosodium glutamate (MSG) on extracellular glutamate levels in rat striata, using in vivo microdialysis. Parenteral doses (0.5, 1.0 and 2.0, but not 0.25, g/kg, i.p.) caused dose- and time-dependent increases, peaking after 40 min (at 174 +/- 47%, 485 +/- 99% and 1021 +/- 301% of basal levels, respectively). In contrast, dietary MSG (1.49 +/- 0.10 g/kg/h) was ineffective.
authors: Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Cambridge 02142.
authors: M B
authors: MB
authors: Bogdanov
authors: R J
authors: RJ
authors: Wurtman
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D017551:Microdialysis / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D018698:Glutamic Acid; D012970:Sodium Glutamate