Glycyrrhizin and 18 beta-glycyrrhetinic acid: a comparative study of the pharmacological effects induced in the rat after prolonged oral treatment.
Recent clinical and toxicological studies have investigated the mineralcorticoid-like and hypertensive effects of liquorice, and we therefore set out to identify the active component responsible for these effects. We conducted a 30-day comparative analysis of glycyrrhizin and 18 beta-glycyrrhetinic acid and found that the latter causes significant variations both in systolic blood pressure and in the excretion in the urine of Ca++. The effects were fully reversible on suspension of treatment.
Rossi
T
T
Department of Pharmaceutical Sciences, University of Modena, Italy.
Vampa
G
G
Benvenuti
S
S
Pini
L A
LA
Galatulas
I
I
Bossa
R
R
Castelli
M
M
Ruberto
A I
AI
Baggio
G
G
D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019695:Glycyrrhizic Acid; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid; D002118:Calcium