Antimyosin scintigraphy in patients with acquired and hereditary muscular disorders.
Scintigraphy with indium-111 labelled antimyosin has an established role in the evaluation of cardiac muscle damage. This antibody has been shown to cross-react with myosin in skeletal muscle. We therefore studied the usefulness of this method for the detection of skeletal muscle lesions in rhabdomyolysis, myositis and hereditary muscular dystrophies. All nine patients with rhabdomyolysis had focal uptake of antimyosin antibody which correlated with the clinical findings of soft tissue damage. However, a number of symptomless lesions were also detected by immunoscintigraphy. In rhabdomyolysis the target to non-target uptake ratios varied from 1.3 to 7.6. Diffuse uptake of antibody in skeletal muscle was observed in all three patients with polymyositis-dermatomyositis and in 12 out of 13 patients with muscular dystrophies. In myositis the intensity of antibody accumulation correlated reasonably well with the magnitude of oedema detected by magnetic resonance imaging (MRI). Most patients with Becker type or non-X-chromosomal muscular dystrophies showed slight or moderate uptake of antibody, mainly in the lower extremities. In these patients more antibody accumulated in the calves than in the thighs, whereas the findings on MRI were more prominent in the thighs than in the calves, presumably because of the better preserved muscle bulk in the calves. We conclude that antimyosin scintigraphy can be used for the detection of muscle lesions not only in acquired muscle diseases but also in hereditary muscular disorders, and that immunoscintigraphy provides information on muscle disease activity not obtainable with MRI.
Löfberg
M
M
Department of Neurology, Helsinki University Central Hospital, Finland.
Liewendahl
K
K
Savolainen
S
S
Nikkinen
P
P
Lamminen
A
A
Tiula
E
E
Somer
H
H
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000473:pathology; D009136:Muscular Dystrophies / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics; D009220:Myositis / Q000175:diagnosis / Q000000981:diagnostic imaging*; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D012206:Rhabdomyolysis / Q000000981:diagnostic imaging*
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C058899:imciromab pentetate