[The association of Epstein-Barr virus with Hodgkin's lymphoma in childhood].
Specimens from 82 children with Hodgkin's lymphoma were studied by immunohistochemical technique for Epstein-Barr virus encoded latent membrane protein (LMP). LMP was demonstrated in 67 cases 81.7%, the positive rate for the mixed cellular subtype was 90.9%. The positive rate for the 3-5 year old group of patients was 100%, 75% for the 6-10 year old group and only 62.5% for the 11-14 year old group. These findings suggest that Epstein-Barr virus is strongly associated with Hodgkin's lymphoma, the younger the age, the stronger the association. Mixed cellular subtype of Hodgkin's lymphoma had the strongest association with Epstein-Barr virus among all subtypes.
Li
P J
PJ
Department of Pathology, Beijing Children's Hospital.
Zhou
X G
XG
Liu
S R
SR
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000378:metabolism / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009856:Oncogene Proteins, Viral / Q000032:analysis*; D014763:Viral Matrix Proteins / Q000032:analysis*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D009856:Oncogene Proteins, Viral; D014763:Viral Matrix Proteins