title: [Tumor-induced anemia and markers of inflammation].
abstract: Anemia of cancer patients is multifactorial but often resembles anemia of chronic inflammatory disorders. We investigated the possibility of measurably increased parameters of inflammation in the serum of cancer patients and examined the correlation of hemoglobin levels, serum iron, and markers of inflammatory response in 201 cancer patients. Serum levels of CRP, ferritin, s-IL-2R, neopterin levels and TNF were assayed with ELISA tests. Statistically significant correlations were found between hemoglobin levels, CRP (Pearson's R = -0.451; p < 0.0001), serum iron (R = 0.326) and ferritin levels (R = -0.449). No significant correlations were seen between hemoglobin levels and neopterin or s-IL-2R. The correlation between hemoglobin levels in cancer patients and elevated markers of inflammatory responses, such as CRP, suggest that cytokines involved in the inflammatory responses may be at least partially responsible, directly or indirectly, for anemia in cancer patients.
authors: Medizinische Klinik C, Kantonsspital St. Gallen.
authors: R
authors: R
authors: Morant
authors: L
authors: L
authors: Bacchus
authors: J
authors: J
authors: Meyer
authors: W F
authors: WF
authors: Riesen
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000209:etiology*; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D002097:C-Reactive Protein / Q000302:isolation & purification; D005260:Female; D005293:Ferritins / Q000097:blood*; D006454:Hemoglobins / Q000302:isolation & purification; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications*; D019798:Neopterin; D015375:Receptors, Interleukin-2 / Q000302:isolation & purification; D014409:Tumor Necrosis Factor-alpha / Q000302:isolation & purification
chemical_list: D006454:Hemoglobins; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D001708:Biopterins; D019798:Neopterin; D002097:C-Reactive Protein; D005293:Ferritins
vernacular_title: Tumoranämie und Entzündungsmarker.