Effect of bismuth subsalicylate on ciprofloxacin bioavailability.
A single oral dose of 528 mg of bismuth subsalicylate (30 ml of Pepto-Bismol) had no significant effect on the plasma pharmacokinetics of a single oral dose of 750 mg of ciprofloxacin administered to 12 healthy volunteers (six men and six women). These results suggest that ciprofloxacin bioavailability will not be significantly decreased by single doses of bismuth subsalicylate when the two medications are administered simultaneously.
Rambout
L
L
Clinical Investigation Unit, Ottawa General Hospital, Ontario, Canada.
Sahai
J
J
Gallicano
K
K
Oliveras
L
L
Garber
G
G
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D001729:Bismuth / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D012459:Salicylates / Q000494:pharmacology*
D009942:Organometallic Compounds; D012459:Salicylates; D002939:Ciprofloxacin; C015715:bismuth subsalicylate; D001729:Bismuth