Drenching sweats as an off phenomenon in Parkinson's disease: treatment and relation to plasma levodopa profile.
We followed 4 patients with Parkinson's disease and severe, intermittent, drenching sweats. One patient was studied with serial plasma levodopa levels and simultaneous clinical examinations. She was observed during a severe sweating episode; this was associated with subtherapeutic plasma levodopa levels (low dopa state). All 4 patients' sweats responded favorably to the institution of agonist therapy. Drenching sweats should be considered part of the spectrum of off-period levodopa-related fluctuations in Parkinson's disease.
Sage
J I
JI
Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
Mark
M H
MH
D000368:Aged; D001971:Bromocriptine / Q000627:therapeutic use; D000077465:Cabergoline; D002819:Chorea / Q000139:chemically induced / Q000188:drug therapy; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004873:Ergolines / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy*; D010479:Pergolide / Q000009:adverse effects / Q000627:therapeutic use; D013546:Sweating / Q000187:drug effects*
D018491:Dopamine Agonists; D004873:Ergolines; D010479:Pergolide; D001971:Bromocriptine; D007980:Levodopa; D000077465:Cabergoline