[Evidence of fluoride-induced effects on the calcaneus by measurements of broadband ultrasound attenuation (BUA)].
We measured broadband ultrasound attenuation (BUA) of the calcaneus as well as radial (RBD) and spinal bone density (SBD) in normal and osteoporotic females (n = 188) both before treatment and after long-term fluoride therapy. RBD was measured using single photon absorptiometry of the non-dominant distal forearm (SPA) and spinal bone density (SBD) was assessed using quantitative CT (QCT). In untreated osteoporotic patients (n = 62), BUA as well as the other densitometric methods showed significantly lower values (p < 0.05) when compared to age matched controls (n = 75). Females with osteoporosis and long-term treatment with fluoride (n = 51) had both significantly higher BUA values and higher spinal bone density when compared to women with untreated osteoporosis. BUA and SBD were correlated in the entire group (r = 0.5, r < 0.0001) as well as in the subgroups of untreated (r = 0.48, p < 0.001) and fluoride-treated patients with osteoporosis (r = 0.4, p < 0.05). These results suggest that BUA provides further evidence of an osteogenic response to fluoride at peripheral weight-bearing skeletal sites such as the calcaneus.
Resch
A
A
Universitätsklinik für Radiodiagnostik, Wien, Austria.
Pietschmann
F
F
Bernecker
P
P
Rand
T
T
Willvonseder
R
R
Resch
H
H
D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density; D002111:Calcaneus / Q000000981:diagnostic imaging* / Q000187:drug effects*; D003720:Densitometry / Q000379:methods; D005069:Evaluation Studies as Topic; D005260:Female; D005459:Fluorides / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011884:Radius / Q000000981:diagnostic imaging; D013131:Spine / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D005459:Fluorides
Hinweis auf fluoridinduzierte Effekte am Kalkaneus durch Messungen der Breitband-Ultraschallabschwächung (BUA).