Myocardial damage during ischaemia and reperfusion.
Large quantities of oxygen free radicals can be generated on reperfusion of the ischemic myocardium. This phenomenon is probably responsible for a specific component of cell damage separate from ischemic injury and may blunt the beneficial effects of thrombolysis. Anti-free radical interventions may reduce the severity of this "reperfusion injury". However, reports of treatment failures indicate that reperfusion injury is a complex phenomenon, and suggest that the beneficial effects of treatment may be critically dependent on factors that are not clearly understood.
Chiariello
M
M
Division of Cardiology, Federico II School of Medicine, Naples, Italy.
Ambrosio
G
G
D000818:Animals; D005609:Free Radicals; D006801:Humans; D017202:Myocardial Ischemia / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000209:etiology*; D017382:Reactive Oxygen Species
D005609:Free Radicals; D017382:Reactive Oxygen Species