Lissencephaly-1 is one of the most conserved proteins between mouse and human: a single amino-acid difference in 410 residues.
The nucleotide (nt) sequence of the LIS-1 cDNA encoding the murine lissencephaly-1 (LIS-1) protein has been determined. The deduced protein shows a very high degree (99.8%) of homology with human LIS-1, having a single conservative amino acid (aa) change out of 410 aa and is identical to a subunit of bovine platelet-activating factor (PAF) acetylhydrolase.
Péterfy
M
M
Amgen Inc., Thousand Oaks, CA 91320.
Gyuris
T
T
Basu
R
R
Takács
L
L
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000737:chemistry; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D051379:Mice / Q000235:genetics*; D008869:Microtubule-Associated Proteins; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D008869:Microtubule-Associated Proteins; D011506:Proteins; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C084102:PAFAH1B1 protein, human; C513190:Pafah1b1 protein, mouse