Copper/zinc superoxide dismutase mRNA levels are increased in sporadic amyotrophic lateral sclerosis motorneurons.
Mutations of the Cu/Zn superoxide dismutase (SOD-1) gene were recently implicated in the pathogenesis of familial amyotrophic lateral sclerosis (ALS). We measured SOD-1 mRNA levels in motorneurons of the more common sporadic form of the disease and found a 42% increase in ALS motorneurons (P = 0.058) as compared with controls. These results suggest that oxidative stress may also play a role in the pathogenesis of sporadic ALS.
Bergeron
C
C
Centre for Research in Neurodegenerative Diseases, University of Toronto, Ont., Canada.
Muntasser
S
S
Somerville
M J
MJ
Weyer
L
L
Percy
M E
ME
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D008875:Middle Aged; D009046:Motor Neurons / Q000378:metabolism*; D018384:Oxidative Stress; D012333:RNA, Messenger / Q000378:metabolism*; D012016:Reference Values; D013482:Superoxide Dismutase / Q000235:genetics*
D012333:RNA, Messenger; D013482:Superoxide Dismutase