[Gingival overgrowth in patients under cyclosporin-A treatment. A clinical study].
The aim of the present study was to investigate possible background factors causing gingival overgrowth (GO) among transplant patients treated with cyclosporine-A (Cy-A). Nineteen subjects were evaluated with regard to Cy-A therapy including: whole blood concentration, oral dosage, duration of therapy, cumulative exposure factor. Periodontal condition was assessed using Plaque Index, probing depth and probing attachment level. GO was assessed on plaster study models by a semiquantitative method. The occurrence of GO was 88%, with a total 35.9% of gingival sites presenting overgrowth. Statistical analysis showed no correlation between GO score on one hand, oral dosage, exposure factor and plaque score on the other. ANOVA revealed a significant relationship between GO score and percentage of affected sites.
Schincaglia
G P
GP
Istituto di Clinica Odontoiatrica, Università degli Studi di Ferrara.
Trombelli
L
L
Zangari
F
F
Scabbia
A
A
Griselli
A
A
Calura
G
G
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005885:Gingival Hyperplasia / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D007165:Immunosuppression Therapy; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009911:Oral Hygiene Index; D016035:Pancreas Transplantation
D016572:Cyclosporine
Aumento di volume gengivale nei pazienti in trattamento con cyclosporina-A. Studio clinico.