Experimental studies on immune-complex in situ type glomerulonephritis in rabbits treated with mai-luo-tong and natural indigo.
By injection of C-BSA, immune-complex in situ type glomerulonephritis was duplicated in rabbits and treated with Mai-Luo-Tong and natural Indigo. The results showed that proteinuria in the treated groups M and Q was decreased. The difference between group M and control group is statistically significant (P < 0.05). Under light and electron microscope, although glomerular basement membrane was irregularly thickened and subepithelial dense electron deposited in the treated group, but microthrombus, erythrocytes and platelets aggregation and leukocytes impaction were not seen within glomerular capillaries. Also in groups C, Q, M, mesenteric cell count was 99.40 +/- 18.53, 92.87 +/- 17.89, 66.55 +/- 7.75 respectively, the M. Q groups are compared with group C, the result is of statistical significance (P < 0.05) and there is no apparent glomerular fibrosis in the treated groups.
Sun
S L
SL
Department of Nephrology, Tongji Hospital, Tongji Medical University, Wuhan.
Yi
H P
HP
Wang
Q L
QL
Huang
S Z
SZ
Liu
X C
XC
D000818:Animals; D000936:Antigen-Antibody Complex / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology*; D007203:Indigo Carmine; D007211:Indoles / Q000627:therapeutic use*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D011507:Proteinuria / Q000188:drug therapy; D011817:Rabbits; D012710:Serum Albumin, Bovine
D000936:Antigen-Antibody Complex; D004365:Drugs, Chinese Herbal; D007211:Indoles; D012710:Serum Albumin, Bovine; D007203:Indigo Carmine