title: High serum alpha-tocopherol, albumin, selenium and cholesterol, and low mortality from coronary heart disease in northern Finland.
abstract: OBJECTIVE
  The mortality from coronary heart disease (CHD) is exceptionally low in northernmost Finland, the Sámi (formerly known as Lapp) area. To clarify the reasons for this, the levels of serum cholesterol, other classic risk factors, and major antioxidants, alpha-tocopherol, retinol, albumin and selenium were determined in males living in the low-mortality area and in a reference area.
  
  
  METHODS
  A health survey amongst reindeer herdsmen living in the three northernmost communes of Finland (the Sámi area) and in the six neighbouring communities to the south (the reference area). The mortality from CHD in the two areas was determined from death certificates issued during the period 1981-1990.
  
  
  METHODS
  A total of 350 participants of the health survey, mean age 46 (SD 14) years.
  
  
  RESULTS
  The mortality from CHD was 17% lower in the Sámi area than in the reference area [95% confidence interval (CI) for the difference: 4-29]. Subjects living in the low-mortality area showed higher serum-lipid-adjusted alpha-tocopherol (18.4 vs. 16.1 mumol L-1; 95% CI for difference: 0.7-3.9; P < 0.001), albumin (46.9 vs. 46.2 g L-1; 0.2-1.3; P < 0.02), selenium (1.59 vs. 1.47 mumol L-1; 0.02-0.22; P < 0.02), cholesterol (6.76 vs. 6.34 mmol L-1; 0.12-0.72; P < 0.001) and LDL cholesterol (4.76 vs. 4.45 mmol L-1; 0.05-0.57; P < 0.02) than those in the reference area. The HDL cholesterol:cholesterol ratio was lower in the Sámi area than in the reference area (0.20 vs. 0.21; -0.02-0.00; P < 0.04). The Sámis showed higher serum selenium than the Finns. Serum alpha-tocopherol increased with the consumption of reindeer meat and serum selenium increased with fish consumption.
  
  
  CONCLUSIONS
  Alpha-tocopherol, albumin and selenium may play a role in the low mortality from CHD observed in northernmost Finland. The favourable serum antioxidant status in northerners may be credited to the local diet.
authors: Oulu Regional Institute of Occupational Health, University of Oulu, Finland.
authors: P V
authors: PV
authors: Luoma
authors: S
authors: S
authors: Näyhä
authors: K
authors: K
authors: Sikkilä
authors: J
authors: J
authors: Hassi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000401:mortality*; D004032:Diet; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012643:Selenium / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis*; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood*
chemical_list: D012709:Serum Albumin; D014801:Vitamin A; D014810:Vitamin E; D002784:Cholesterol; D012643:Selenium