Selenium deficiency triggering intractable seizures.
Two children with severe neurodevelopmental retardation and elevated liver function tests developed intractable seizures during the first year of life. Detectable neurometabolic conditions have been ruled out. At the time of seizures evidence for systemic selenium deficiency could be documented. The youngest patient, who manifested intractable fits from the fourth day of life, died at the age of ten months. Neuropathologic examination was consistent with Progressive Neuronal Degeneration of Childhood (PNDC) with liver disease or formerly known as Alpers disease. In the oldest child, whose diet was normally balanced, fits started from the age of 11 months and features of long-standing selenium deficiency became apparent from the age of 1 1/2 years and consisted of liver function disturbances, depigmented hair and osteoarthropathy. Oral substitution with selenium supplements in both children (3-5 micrograms/kg body weight) resulted in reduction of seizures and improvement of the EEG recordings after two weeks while liver function became normal. Two of the seleno-dependent enzymes Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX) are speculated to play a key-role in the defence of neuronal cells against oxygen radical formation and peroxidative processes. Our findings support the hypothesis that the presence of selenium depletion in the brain amongst patients with epilepsy constitutes an important triggering factor for the origin of intractable seizures and subsequent neuronal damage.
Ramaekers
V T
VT
Department of Paediatric Neurology, University of Aachen, Germany.
Calomme
M
M
Vanden Berghe
D
D
Makropoulos
W
W
D001284:Atrophy; D001921:Brain / Q000473:pathology; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D009410:Nerve Degeneration / Q000502:physiology; D009460:Neurologic Examination; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D017382:Reactive Oxygen Species / Q000378:metabolism; D012643:Selenium / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000172:deficiency*; D013036:Spasms, Infantile / Q000473:pathology / Q000503:physiopathology*
D005609:Free Radicals; D017382:Reactive Oxygen Species; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase; D012643:Selenium