title: [Toxicology of toluene: aspects related to its abuse].
abstract: Toluene, present in many industrial and domestic products, is the main solvent involved in solvent abuse and occupational exposure. The main problem in studying toluene-related pathologies is the fact that it is frequently combined with other substances. This review focuses on its potential toxicity. The following subjects are discussed: pharmacologic parameters; physico-chemical features; exposure; clinical trials; experimental research; diagnosis; tolerance and dependence; acute and chronic effects; neurotoxicity; teratogenicity; psychiatric disorders; carcinogenicity; and treatment. It is concluded that is important more research on larger population samples with a view to better definition of the consequences of chronic use should be undertaken.
authors: Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, RS, Brasil.
authors: L M
authors: LM
authors: Forster
authors: M
authors: M
authors: Tannhauser
authors: S L
authors: SL
authors: Tannhauser
mesh_terms: D000818:Animals; D004781:Environmental Exposure; D006801:Humans; D016273:Occupational Exposure; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications / Q000175:diagnosis; D014050:Toluene
chemical_list: D014050:Toluene
vernacular_title: Toxicologia do tolueno: aspectos relacionados ao abuso.