Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice.
Immunological tolerance is the process of inhibiting or eliminating lymphocytes that recognize self-derived antigens. By removing potentially harmful self-reactive clones, this mechanism allows for the random generation of a diverse repertoire of T-cells capable of responding to foreign pathogens. Although all self-reactive T-cells should be removed from the repertoire, it is quite clear from many recent studies that a significant fraction of T-cells bearing gamma delta T-cell receptors (TCR) recognize self-derived antigens in normal healthy mice. The presence of self-reactive T-cells in healthy animals presents a paradox which may be explained by understanding the transient expression of the antigens (e.g., MHC class Ib, Heat Shock Proteins) that have been identified for gamma delta T-cells thus far. Data from experiments with V gamma 1.1C gamma 4 transgenic mice demonstrating the presence of self-reactive gamma delta T-cells and their influence on lymphoid development and immune surveillance will be examined in this review.
Ferrick
D A
DA
Department of Veterinary Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616.
Gemmell-Hori
L
L
Sydora
B
B
Mulvania
T
T
Penninger
J M
JM
Kronenberg
M
M
Mak
T W
TW
D000818:Animals; D000831:Animals, Newborn; D015551:Autoimmunity; D004848:Epithelium / Q000276:immunology; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology*; D017634:Self Tolerance; D016176:T-Lymphocyte Subsets / Q000276:immunology
D016692:Receptors, Antigen, T-Cell, gamma-delta