title: Long-term clinical effect of nilvadipine in patients with chronic heart failure: a double-blind placebo-controlled study.
abstract: The long-term effect of calcium channel blockers on chronic heart failure is disappointing, probably because of reflex sympathetic activation through arterial vasodilation. However, nilvadipine may be beneficial for treatment of chronic heart failure since this drug has minimal effects on sympathetic activation. In this study, the effects of 12-week administration of nilvadipine or placebo on symptoms of heart failure and cardiac function were investigated in 23 patients with mild-to-moderate chronic heart failure in a double-blind trial. The patients were randomly assigned to either a nilvadipine group (16 mg daily) or a placebo group. Intergroup comparisons did not show significant differences in any parameters. Serious adverse effects were not observed during the study. Thus, this study failed to show any beneficial effect of nilvadipine in the long-term treatment of patients with chronic heart failure. We conclude that the long-term administration of nilvadipine (16 mg daily) is neither effective nor harmful in the treatment of patients with chronic heart failure.
authors: First Department of Medicine, Osaka University School of Medicine, Japan.
authors: M
authors: M
authors: Hori
authors: H
authors: H
authors: Sato
authors: M
authors: M
authors: Karita
authors: K
authors: K
authors: Kodama
authors: N
authors: N
authors: Hoki
authors: T
authors: T
authors: Hayashi
authors: M
authors: M
authors: Naka
authors: S
authors: S
authors: Nanto
authors: Y
authors: Y
authors: Yamada
authors: T
authors: T
authors: Kamada
mesh_terms: D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D017079:Exercise Tolerance / Q000187:drug effects; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D002121:Calcium Channel Blockers; C035100:nilvadipine; D009543:Nifedipine