title: Umbilical cord blood gas analysis at delivery: a time for quality data.
abstract: OBJECTIVE
  To address the practical problems of routine umbilical cord blood sampling, to determine the ranges for pH, PCO2 and base deficit and to examine the relationships of these parameters between cord vessels.
  
  
  METHODS
  An observational study of umbilical cord artery and vein blood gas results.
  
  
  METHODS
  A large district general hospital in the UK.
  
  
  METHODS
  One thousand nine hundred and forty-two cord results from 2013 consecutive pregnancies of 34 weeks or more gestation, monitored by fetal scalp electrode during labour.
  
  
  RESULTS
  Only 1448 (74.6%) of the 1942 supposedly paired samples had validated pH and PCO2 data both from an artery and the vein; 54 (2.8%) had only one blood sample available, 90 (4.6%) had an error in the pH or PCO2 of one vessel and in 350 (18%) pairs the differences between vessels indicated that they were not sampled from artery and vein as intended. Only 60% of the cases with an arterial pH less than 7.05 had evidence of a metabolic acidosis (base deficit in the extracellular fluid 10 mmol/l or more). Of all the cases, 2.5% had a venous-arterial pH difference greater than 0.22 units.
  
  
  CONCLUSIONS
  Both artery and vein cord samples must be taken and the results screened to ensure separate vessels have been sampled. Interpretation of the results requires the examination of PCO2 and base deficit of the extracellular fluid from each vessel as well as the pH. Confusion about the value of cord gas measurements may be due to the use of erroneous data and inadequate definitions of acidosis which do not differentiate between respiratory and metabolic components.
authors: Postgraduate Medical School, Department of Obstetrics, Derriford Hospital, Plymouth, UK.
authors: J
authors: J
authors: Westgate
authors: J M
authors: JM
authors: Garibaldi
authors: K R
authors: KR
authors: Greene
mesh_terms: D002245:Carbon Dioxide / Q000097:blood*; D036861:Delivery, Obstetric; D004739:England; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005323:Fetal Monitoring; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010313:Partial Pressure; D011247:Pregnancy; D011295:Prenatal Care / Q000592:standards*; D011787:Quality of Health Care; D012680:Sensitivity and Specificity; D014469:Umbilical Arteries; D014471:Umbilical Veins
chemical_list: D002245:Carbon Dioxide