The monoamine content of the brain in the neurofilament-deficient quail, (the Quiver quail).
Changes in neurotransmission are known to take place in a variety of conditions, such as Parkinson's disease. A neurofilament-deficient mutant of the Japanese quail, named the Quiver quail, exhibits generalized quivering as a clinical sign. The content of monoamines (noradrenaline (NA), dopamine and 5-hydroxytryptamine) and the uptake and release of L-[3H]NA were measured in brain of this bird. In Quiver, the NA content in neostriatum and thalamus, and the 5-hydroxytryptamine content in neostriatum, paleostriatum and thalamus were significantly increased, in comparison with the normal quail. The dopamine content and L-[3H]NA uptake and release in the Quiver mutant were similar to those in normal quail.
Hasegawa
H
H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Murayama
T
T
Takahashi
A
A
Itakura
C
C
Nomura
Y
Y
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001923:Brain Chemistry / Q000235:genetics*; D003370:Coturnix / Q000235:genetics / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics* / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D015306:Biogenic Monoamines; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine