title: Coadministration of fluvoxamine increases serum concentrations of haloperidol.
abstract: Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly elevated by fluvoxamine.
authors: Clinical Brain Disorders Branch, NIMH Neuroscience Center at Saint Elizabeths, Washington, D.C.
authors: D G
authors: DG
authors: Daniel
authors: C
authors: C
authors: Randolph
authors: G
authors: G
authors: Jaskiw
authors: S
authors: S
authors: Handel
authors: T
authors: T
authors: Williams
authors: A
authors: A
authors: Abi-Dargham
authors: S
authors: S
authors: Shoaf
authors: M
authors: M
authors: Egan
authors: A
authors: A
authors: Elkashef
authors: S
authors: S
authors: Liboff
mesh_terms: D000328:Adult; D001590:Benztropine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D002908:Chronic Disease; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D016666:Fluvoxamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D001590:Benztropine; D006220:Haloperidol; D016666:Fluvoxamine