Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent.
We inoculated four rhesus macaques with molecularly cloned simian immunodeficiency virus SIVmac239/17E env, a chimeric virus whose env gene was derived from the brain of an SIV-encephalitic macaque. Blood and lymphoid tissues had high frequencies of infected cells. The virus was neuroinvasive, but productive virus replication did not occur in the brain, and animals did not develop encephalitis.
Joag
S V
SV
Marion Merrell Dow Laboratory of Viral Pathogenesis, Department of Microbiology, University of Kansas Medical Center, Kansas City 66160-7424.
Stephens
E B
EB
Galbreath
D
D
Zhu
G W
GW
Li
Z
Z
Foresman
L
L
Zhao
L J
LJ
Pinson
D M
DM
Narayan
O
O
D000818:Animals; D001921:Brain / Q000821:virology*; D018791:CD4 Lymphocyte Count; D002678:Chimera; D004660:Encephalitis / Q000821:virology*; D015683:Gene Products, gag / Q000032:analysis; D015752:Genes, env; D008253:Macaca mulatta; D008264:Macrophages / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000472:pathogenicity*; D014774:Virulence
C066594:Gag protein p27, Simian immunodeficiency virus; D015683:Gene Products, gag