title: Depressed immune surveillance against cancer: role of deficient T cell: extracellular matrix interactions.
abstract: Although T cells infiltrate malignant tumors, the local immune response is usually inefficient and tumors escape destruction. While extracellular matrix proteins strongly costimulate T cell responses in normal individuals, our studies indicate that peripheral blood T cells from cancer patients and tumor infiltrating cells respond poorly or are resistant to stimulative signals mediated by collagen I and IV and fibronectin. Moreover, the adhesive properties of cancer T cells are markedly depressed. Those functional deficiencies are paralleled by variable deficits in integrin and non-integrin T cell receptors for extracellular matrix. Immunotherapy with BCG causes a dramatic but transient increase in T cell: ECM interactions.
authors: Warsaw Medical School, University of Liege, Belgium.
authors: A
authors: A
authors: Górski
authors: V
authors: V
authors: Castronovo
authors: B
authors: B
authors: Stepień-Sopniewska
authors: P
authors: P
authors: Grieb
authors: M
authors: M
authors: Ryba
authors: T
authors: T
authors: Mrowiec
authors: G
authors: G
authors: Korczak-Kowalska
authors: P
authors: P
authors: Wierzbicki
authors: W
authors: W
authors: Matysiak
authors: B
authors: B
authors: Dybowska
mesh_terms: D001500:BCG Vaccine / Q000627:therapeutic use; D005109:Extracellular Matrix / Q000276:immunology*; D016326:Extracellular Matrix Proteins / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D001500:BCG Vaccine; D016326:Extracellular Matrix Proteins