[Effects of fibronectin on cell attachment and migration of human tongue squamous cancer line Tca8113].
By using the cell culture technique in vitro, quantitative studies were carried out to test the effects of fibronectin (FN) on cell biological behaviour of human tongue squamous cancer line Tca8113 in terms of cell attachment to rat-tail collagen substrata supplemented with different concentration of FN or/and anti-FN serum as well as cell migrating distance from the agarose drop cultured with different media containing FN or/and anti-FN serum. The results displayed that FN could increase the density of cells attached to collagen substrata; the cell attachment was dose-dependent on FN. In addition, cell migration from the agarose drop might be induced and cell motility might be promoted by FN. Anti-FN serum could abolish or weaken the above-mentioned FN effects.
Xiao
Y
Y
Yang
F
F
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D005353:Fibronectins / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D014062:Tongue Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured
D005353:Fibronectins; D007106:Immune Sera