NMDA redox site modulates long-term potentiation of NMDA but not of AMPA receptors.
We have compared the effects of redox drugs on long-term potentiation mediated by AMPA or NMDA receptors. A reducing and an oxidizing agent had no effect on long-term potentiation mediated by AMPA receptors. In contrast, the induction of long-term potentiation mediated by NMDA receptors was prevented by a thiol oxidizing drug and restored by a disulfide reducing agent.
Gozlan
H
H
INSERM U-29, Hôpital de Port-Royal, Paris, France.
Chinestra
P
P
Diabira
D
D
Ben-Ari
Y
Y
D000818:Animals; D004220:Disulfides / Q000737:chemistry; D004228:Dithionitrobenzoic Acid / Q000494:pharmacology; D004594:Electrophysiology; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D010720:Phosphines / Q000494:pharmacology; D051381:Rats; D018091:Receptors, AMPA / Q000187:drug effects / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000737:chemistry
D004220:Disulfides; D004228:Dithionitrobenzoic Acid; D007202:Indicators and Reagents; D010720:Phosphines; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D013438:Sulfhydryl Compounds; C080938:tris(2-carboxyethyl)phosphine