O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
Tumour samples obtained from one primary melanoma and several lymph node and skin metastases were analysed for O6-methylguanine-DNA methyltransferase (MGMT) activity. While lymph node and skin metastases had similar average MGMT activity, the variance was significantly higher in lymph node metastases. Variability in MGMT activity was frequently observed in different metastases in the same individual and to a lesser extent within metastases.
Egyházi
S
S
Department of Experimental Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Hansson
J
J
Ringborg
U
U
D001706:Biopsy; D006801:Humans; D008545:Melanoma / Q000201:enzymology* / Q000473:pathology; D008780:Methyltransferases / Q000378:metabolism*; D019853:O(6)-Methylguanine-DNA Methyltransferase
D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase