title: In vitro fertilization and oocyte donation in women 45 years of age and older.
abstract: OBJECTIVE
  To assess the reproductive potential in women > or = 45 years of age.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  In vitro fertilization-embryo transfer unit, standard IVF and oocyte donation programs.
  
  
  METHODS
  One hundred twenty-seven patients > or = 45 years old who applied for treatment of infertility.
  
  
  METHODS
  Thirty-one patients underwent 52 treatment cycles in standard IVF. Ninety-six patients underwent 220 oocyte donation cycles.
  
  
  RESULTS
  Of the 52 standard IVF cycles, oocytes were retrieved successfully in only 32. Of these, fertilization and ET were performed in 21 cycles. None of these treatment cycles resulted in a clinical pregnancy. Of the 220 oocyte donation cycles, fertilization and ET were accomplished in 189 cycles. These resulted in 33 (17.5% per transfer) clinical pregnancies.
  
  
  CONCLUSIONS
  These results suggest that oocyte donation may extend the reproductive potential in women > or = 45 years old when little hope is offered by standard IVF.
authors: In Vitro Fertilization-Embryo Transfer Units, Tel Aviv Sourasky Medical Center, Israel.
authors: Y
authors: Y
authors: Yaron
authors: A
authors: A
authors: Amit
authors: S M
authors: SM
authors: Brenner
authors: M R
authors: MR
authors: Peyser
authors: M P
authors: MP
authors: David
authors: J B
authors: JB
authors: Lessing
mesh_terms: D004624:Embryo Transfer; D005240:Feasibility Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D018587:Oocyte Donation; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies