Sensory irritating properties of cyanuric chloride as revealed with plethysmographic method.
Sensory respiratory irritation properties of cyanuric chloride (2,4,6-trichlorotriazine; CC) were studied in mice. For this purpose, the respiratory rate was measured in Balb/C male mice by means of the whole body plethysmographic method. Each animal was placed in a body plethysmograph attached to a small (0.25 m3) dynamic inhalation chamber and exposed to various concentrations (2.1, 6.7, 9.1, 11.7 and 14.6 mg/m3) of CC. Respiratory rates were recorded before, during and after termination of the exposure. It was found that exposure to CC caused a concentration-dependant decrease of respiratory rates in mice. After termination of exposure fast and full recovery of respiratory rates were observed within 5 minutes. RD50 value calculated with probit method was established as 5.9 (1.3-13.9 for 95% confidence limits) mg/m3. The slope of the dose response curve was 1.366 (0.78). It is concluded that cyanuric chloride is a strong respiratory irritant.
Rydzyński
K
K
Department of Toxicity Evaluation, Nofer Institute of Occupational Medicine, Lodz, Poland.
Jedrychowski
R
R
D000818:Animals; D003432:Cross-Linking Reagents / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010993:Plethysmography, Whole Body; D012119:Respiration / Q000187:drug effects*; D012137:Respiratory System / Q000187:drug effects; D014227:Triazines / Q000009:adverse effects*
D003432:Cross-Linking Reagents; D014227:Triazines; C019309:cyanuric chloride