Developmental and gestational changes of phosphoethanolamine and taurine in rat brain, striated and smooth muscle.
Concentrations of taurine and phosphoethanolamine in rat smooth (intestinal and uterine), skeletal and cardiac muscle, and brain have been determined, using high-performance liquid chromatography (HPLC), to examine possible interrelationships in their tissue content. Concentrations were determined in fetal and neonatal samples, as well as in adult tissue, to investigate whether phosphoethanolamine and taurine levels are influenced by developmental state. The effect of gestational state was also studied. A marked decrease in cerebral phosphoethanolamine concentration during development was found together with a concomitant decrease in striated muscle but not in the two smooth muscles studied. A rise in uterine phosphoethanolamine during the early postpartum period confirmed previous NMR data. This occurred only in the uterus, suggesting it is specific to the process of involution within the myometrium. Taurine concentrations showed no consistent pattern of change with postnatal development. In adult animals, the highest levels of taurine were found in cardiac muscle. Pregnancy was associated with a fall in taurine concentration in all tissues, suggesting an influence of steroid hormones. As taurine is cotransported with Na+ in many systems it may be related to the increased water retention seen in pregnancy. It is concluded that marked changes in phosphoethanolamine and taurine levels occur during development and gestation, but that the changes are not interdependent, i.e., the changes are tissue specific.
Turner
O
O
Physiological Laboratory, University of Liverpool.
Phoenix
J
J
Wray
S
S
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004983:Ethanolamines / Q000378:metabolism*; D005260:Female; D005318:Fetal Heart / Q000378:metabolism; D006321:Heart / Q000254:growth & development; D007421:Intestine, Small / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D009130:Muscle, Smooth / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009215:Myometrium / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000378:metabolism*
D004983:Ethanolamines; D013654:Taurine; C005448:phosphorylethanolamine