Oral administration of monensin and lead to broiler chicks: effects on haematological and biochemical parameters.
Monensin and lead were administered separately or concurrently at different toxic doses to broiler chicks. Administration of lead alone did not result in a significant depression of haematological parameters. Administration of higher levels of monensin caused a reduction in haematocrit and an increase in blood serum levels of alanine aminotransferase, aspartate aminotransferase and cholesterol. Concurrent administration of monensin and lead caused a severe depression of haematological profiles which indicated the existence of an interaction between the two substances. It was concluded that concurrent administration of monensin and lead potentiated the toxic effects of each other.
Khan
M Z
MZ
Department of Forensic Veterinary Medicine, Faculty of Veterinary Medicine, University of Agriculture and Technology, Olsztyn, Poland.
Szarek
J
J
Koncicki
A
A
Krasnodebska-Depta
A
A
D000284:Administration, Oral; D000818:Animals; D002645:Chickens / Q000097:blood*; D004906:Erythrocyte Count / Q000187:drug effects; D006400:Hematocrit; D006454:Hemoglobins / Q000187:drug effects; D007854:Lead / Q000008:administration & dosage*; D007958:Leukocyte Count / Q000187:drug effects; D008985:Monensin / Q000008:administration & dosage*
D006454:Hemoglobins; D007854:Lead; D008985:Monensin