[Determination of the sensitivity of echography in prenatal diagnosis of fetal malformations. Methodological aspects].
In the article, following Eddy's work we show that the ratio of the number of cases detected by echography to the total number of cases is not a consistent estimator of test sensitivity of the pathology over time. In such conditions, the sensitivity of the test function is the only correct way to evaluate the test's ability to detect pathologic cases in an asymptomatic population. From a methodological point of view, if the time of detectability of the condition is considered as a random variable, then the function of sensitivity is estimated by fitting a distribution function to the observed date. In order to illustrate the feasibility and the consistency of our methodology, we present results based on simulated data.
Dervaux
B
B
CRESGE (Labores URA CNRS 362), Université Catholique de Lille.
Leleu
H
H
Levi
S
S
D003198:Computer Simulation; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D005333:Fetus / Q000002:abnormalities*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011786:Quality Control; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000592:standards
Détermination de la sensibilité de l'échographie dans le diagnostic anténatal des malformations foetales. Aspects méthodologiques.