[Clinical and histological effect of induction chemotherapy with peplomycin, vincristine, mitomycin C and cis-platinum on oral squamous cell carcinomas].
Twenty one patients with resectable oral cancer received two courses of induction chemotherapy with peplomycin (PEP), vincristine (VCR), mitomycin C (MMC) and cisplatin (CDDP). Five patients had a complete response to the therapy and 9 had a partial response. Histological evaluation by Ohboshi-Shimozato classification indicated that Grade IV was obtained in 7 cases, Grade III was in 4 cases. Moreover, the study suggested that this regimen was less effective for metastatic lymph lesions than that for the primary tumors.
Shirasuna
K
K
1st Dept. of Oral and Maxillofacial Surgery, Osaka University Faculty of Dentistry.
Ogura
T
T
Mima
T
T
Hiranuma
T
T
Sakai
T
T
Hayashido
Y
Y
Matsuya
T
T
Usui
M
M
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017663:Peplomycin / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D016685:Mitomycin; D017663:Peplomycin; D014750:Vincristine; D002945:Cisplatin