Intact survival with transfusion-associated graft-versus-host disease proved by human leukocyte antigen typing of lymphocytes in skin biopsy specimens.
A transient transfusion-associated graft-versus-host disease occurred in a premature infant of 30 weeks of gestation. We demonstrated donor lymphocytes in a skin biopsy specimen with a two-step immunoperoxidase technique using monoclonal antibodies against human leukocyte antigen determinants specific for the donor. The girl survived and is immunocompetent.
Hentschel
R
R
Department of Pediatrics, University Hospital, Münster, Germany.
Broecker
E B
EB
Kolde
G
G
Frosch
M
M
Friedrich
W
W
Holzgreve
W
W
Westphal
E
E
Harms
E
E
D000911:Antibodies, Monoclonal / Q000276:immunology; D001706:Biopsy; D001787:Blood Group Incompatibility / Q000175:diagnosis / Q000276:immunology; D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology* / Q000401:mortality; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000276:immunology; D012867:Skin / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006680:HLA Antigens