Diarrhoea and increased intestinal permeability in laboratory beagles associated with proximal small intestinal bacterial overgrowth.
Repeated episodes of diarrhoea were seen in 4 laboratory beagles after experimental renal surgery and feeding a modified diet. Small intestinal bacterial overgrowth (SIBO) was suspected by exclusion of other causes and measurement of plasma folate. SIBO was confirmed by quantitative duodenal bacteriology. Beagles with SIBO can show no clinical signs, experimental stress and dietary change may have been reasons why these 4 beagles exhibited clinical signs with SIBO. Despite normal gut histology an increase in gut permeability was found using sugar absorption tests. This increased permeability had the potential to cause variations in drug absorption during experimental studies.
Morris
T H
TH
Department of Laboratory Animal Science, SmithKline Beecham Pharmaceuticals, Harlow, Essex.
Sorensen
S H
SH
Turkington
J
J
Batt
R M
RM
D000818:Animals; D000830:Animals, Laboratory / Q000097:blood / Q000378:metabolism / Q000382:microbiology*; D001424:Bacterial Infections / Q000150:complications / Q000662:veterinary; D050260:Carbohydrate Metabolism; D003967:Diarrhea / Q000178:diet therapy / Q000382:microbiology / Q000662:veterinary; D004283:Dog Diseases / Q000378:metabolism / Q000382:microbiology; D004285:Dogs / Q000097:blood / Q000378:metabolism / Q000382:microbiology*; D007070:Immunoglobulin A / Q000097:blood; D007421:Intestine, Small / Q000378:metabolism* / Q000382:microbiology*; D008297:Male; D010539:Permeability; D013312:Stress, Physiological / Q000150:complications / Q000662:veterinary
D007070:Immunoglobulin A