Anti-class II MHC antibodies prevent and treat EAE without APC depletion.
We have demonstrated that a murine IgG1 anti-class II major histocompatibility complex (MHC) antibody (OX6) is able both to prevent and treat experimental autoimmune encephalomyelitis (EAE) in the Biozzi AB/H mouse. We have confirmed that this antibody is poorly cytotoxic, allowing mechanisms of action other than depletion of antigen-presenting cells (APC) to be assessed. Despite its effect on disease, OX6 administration does not prevent priming of T cells in the draining lymph node, implying an alternative mechanism for regulation of the autoimmune disease process.
Smith
R M
RM
Department of Pathology, University of Cambridge, UK.
Morgan
A
A
Wraith
D C
DC
D000208:Acute Disease; D000595:Amino Acid Sequence; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001327:Autoimmune Diseases / Q000517:prevention & control / Q000628:therapy*; D003602:Cytotoxicity, Immunologic; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000517:prevention & control / Q000628:therapy*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G