Pharmacokinetics of cyclosporin A in 16 newborn infants of renal or cardiac transplant mothers.
Fourteen renal transplant and one heart transplant mothers receiving cyclosporin (mean dosage: 273 +/- 19 mg/day) underwent a Caesarean section at a mean gestational age of 34.1 +/- 1.9 weeks. Circulating cyclosporin was assayed by HPLC. The mean blood levels in the mothers before the Caesarean section were 210 +/- 16 ng/ml, in cord blood 62 +/- 16 ng/ml (14 infants) and in the peripheral blood within 6 h of birth 31 +/- 12 ng/ml (15 infants); there was no correlation between maternal and cord levels, nor between peripheral blood levels at 2 h and cord blood levels. Cyclosporin levels were undetectable at day 3 in 12 infants, but low levels were found in 1 infant up to day 12. There was no toxic effect on the fetus or neonate.
Claris
O
O
Department of Neonatology, Hôpital Edouard Herriot, Lyon, France.
Picaud
J C
JC
Brazier
J L
JL
Salle
B L
BL
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D016572:Cyclosporine / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D016030:Kidney Transplantation / Q000502:physiology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications
D016572:Cyclosporine