title: Pattern of polyamines and related monoacetyl derivatives in chick embryo retina during development.
abstract: Polyamines and related monoacetyl derivatives were studied in chick embryo retina during development (6th-19th day). Putrescine, which is high in the first phase of retinogenesis, is necessary to sustain both tissue proliferation and via N-acetylputrescine, gamma-aminobutyric acid synthesis. A later increase in spermidine and particularly spermine may play a role in the last phase of development when the retina reaches maturation. The presence of N1-acetylspermidine already at the 8th day indicates that in chick embryo retina, putrescine synthesis can depend on two separate pathways. The first involves ornithine decarboxylase activity; the second, spermidine/spermine N1-acetyltransferase and probably polyamine oxidase that converts spermidine to putrescine via N1-acetylspermidine.
authors: Institute of Biological Chemistry, Faculty of Medicine, University of Palermo, Italy.
authors: G
authors: G
authors: Taibi
authors: M R
authors: MR
authors: Schiavo
authors: G
authors: G
authors: Calvaruso
authors: G
authors: G
authors: Tesoriere
mesh_terms: D000818:Animals; D015317:Biogenic Polyamines / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002642:Chick Embryo; D011700:Putrescine / Q000031:analogs & derivatives* / Q000378:metabolism; D012160:Retina / Q000196:embryology / Q000378:metabolism*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000378:metabolism; D013096:Spermine / Q000031:analogs & derivatives* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
chemical_list: D015317:Biogenic Polyamines; C017988:N(1)-acetylspermidine; C029452:N'-acetylspermine; D013096:Spermine; D005680:gamma-Aminobutyric Acid; C026212:N-acetylputrescine; D013095:Spermidine; D011700:Putrescine