[Analysis of cellular and humoral mechanisms of the anti-radiation action of the drug HC-1539].
The agent HC-1539, an analogue of tamoxifen, was studied for its effects on the blood system of intact animals and on the time course of postradiation recovery of hemopoiesis. HC-1539 given to the mice unexposed to radiation reduced bone marrow levels of CFUs (a colony of forming units in the spleen) and CFU-GM (that in the granulocyte-macrophages) and increased splenic counts of granulocyte-macrophage precursors. There was also a decrease in the proliferative activity of CFU-GM 1 and 5 days after the drug administration and an increase in serum GM-CCP levels when the agent showed the peak of its radioprotective effect. In the HC-1539-treated mice, there was a more intensive normalization of the CFUs of CFU-GM myeloid and erythroid hemopoietic populations than in the radiation-exposed ones. Thus, the mechanisms responsible for the radioprotective action of HC-1539 may be associated both with its direct effects on the proliferation and differentiation of hemopoietic cellular precursors and with the stimulation of release of growth-differential factors by hemopoietic microenvironmental elements.
Lebedev
V G
VG
Vorotnikova
T V
TV
Deshevoĭ
Iu B
IuB
D000818:Animals; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology
D011837:Radiation-Protective Agents; C091454:indometafen; D013629:Tamoxifen; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
Analiz kletochnykh i gumoral'nykh mekhanizmov protivoluchevogo deĭstviia preparata HC-1539.