title: Chest pain of undetermined origin.
abstract: Chest pain of undetermined origin (CPUO) can be a diagnostic dilemma for both the primary care physician and subspecialist. This article focuses on the diagnostic tools used in the evaluation of CPUO, which include: prolonged ambulatory intraesophageal pH monitoring; esophageal manometry with provocative testing; ambulatory intraesophageal pressure monitoring; the role of radiology and endoscopy in the evaluation of chest pain; the role of psychological abnormalities and abnormal nociception in the pathogenesis of chest pain; and the clinical approach and treatment rationale for CPUO.
authors: Graduate Hospital, Philadelphia, Pennsylvania.
authors: R J
authors: RJ
authors: Just
authors: D O
authors: DO
authors: Castell
mesh_terms: D001466:Barium Sulfate; D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004491:Edrophonium; D016099:Endoscopy, Gastrointestinal; D015154:Esophageal Motility Disorders / Q000150:complications / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D004945:Esophagoscopy; D004947:Esophagus / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008365:Manometry; D008991:Monitoring, Physiologic; D011312:Pressure; D011602:Psychophysiologic Disorders
chemical_list: D001466:Barium Sulfate; D004491:Edrophonium