title: Activation of mechanonociceptors by pro-inflammatory peptides melittin and PLAP peptide.
abstract: Studies were conducted to characterize the chemical reactivity of A and C fiber mechanical and mechanoheat nociceptors that innervate the goat palatal mucosa. In mechanical nociceptors, no significant chemical reactivity to either serotonin, bradykinin, prostaglandin E1, or prostaglandin E2 was observed, regardless of whether substances were injected singly or in spaced sequential combinations. Weak reactivity was observed in mechanoheat nociceptors. In contrast, both mechanical and mechanoheat nociceptors were activated by novel proinflammatory peptides. Nineteen of 30 mechanonociceptors and 12 of 13 mechanoheat nociceptors were activated by the insect venom peptide, melittin or its endogenous mammalian homologue PLAP (phospholipase A2 activating protein) peptide. Low threshold mechanoreceptors were never activated by melittin or PLAP peptide.
authors: Department of Oral and Maxillofacial Surgery, JHM Health Center, University of Florida, Gainesville 32610.
authors: B
authors: B
authors: Cooper
authors: J S
authors: JS
authors: Bomalaski
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004558:Electric Stimulation; D006041:Goats; D006358:Hot Temperature; D008297:Male; D008555:Melitten / Q000494:pharmacology*; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects; D009475:Neurons, Afferent / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects*; D010159:Palate / Q000187:drug effects / Q000294:innervation; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D011458:Prostaglandins E / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D012668:Trigeminal Ganglion / Q000187:drug effects
chemical_list: D011458:Prostaglandins E; D011506:Proteins; C055324:phospholipase A2-activating protein; D008555:Melitten; D012701:Serotonin; D010741:Phospholipases A; D054467:Phospholipases A2; D001920:Bradykinin