An experimental trial of artemether in treatment of Pneumocystis carinii in immunosuppressed rats.
An immunosuppressed rat model was established by injecting cortisone acetate 25 mg/rat twice a week for 4 weeks and 12.5 mg/rat for another 2 weeks subcutaneously. A development of Pneumocystis carinii pneumonia (PCP) was found at the end of the 6th week in all rats. These rats were injected intramuscularly with artemether at 100 mg/kg once a day for 5 consecutive days. All rats were necropsied at the end of the 8th week. The lung impression smears were stained with Gomori's stain, and Pneumocystis carinii cysts were counted. The ultrastructural changes of trophozoite, precyst and cyst were investigated by transmission electron microscopy on the 7th day after treatment.
Chen
Y T
YT
Institute of Infectious and Parasitic Diseases, Chongqing University of Medical Sciences.
Ma
L
L
Mei
Q
Q
Tang
Y
Y
Liao
X G
XG
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D000077549:Artemether; D037621:Artemisinins; D003348:Cortisone / Q000031:analogs & derivatives; D005260:Female; D016867:Immunocompromised Host; D008168:Lung / Q000382:microbiology; D011010:Pneumocystis / Q000648:ultrastructure; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000627:therapeutic use*
D000935:Antifungal Agents; D037621:Artemisinins; D012717:Sesquiterpenes; D000077549:Artemether; D003348:Cortisone