7-OHDPAT and alcohol consumption, withdrawal and discriminative stimulus properties in rats.
A series of experiments was performed, which indicated that 7-OHDPAT is only active in rats that are still in the dynamic phase of the development of a high and stable level of alcohol preference and in a drug discrimination test procedure, but not in rats with a matured preference for 3% alcohol. These data may point to a limited use of 7-OHDPAT in conditions of alcohol misuse and dependence.
Meert
T F
TF
Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium.
Clincke
G H
GH
D000428:Alcohol Drinking / Q000503:physiopathology*; D000430:Alcohol Withdrawal Delirium / Q000503:physiopathology*; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013649:Taste / Q000187:drug effects / Q000502:physiology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
C493595:Drd3 protein, rat; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; C031349:7-hydroxy-2-N,N-dipropylaminotetralin