title: Polychlorinated biphenyls, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) in human plasma related to fish consumption.
abstract: Fatty fish species, e.g., salmon and herring, in the Baltic Sea have high levels of polychlorinated biphenyls (PCBs) and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT), and its main metabolite: 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE). We determined levels of 10 different PCB congeners, including non- and mono-ortho-PCBs, as well as DDT and DDE, in human blood plasma from 37 subjects with varying intake of fish (0-1 750 g/wk) from the Baltic Sea. With respect to all of the PCB congeners we investigated, as well as for DDT and DDE, there were statistically significant associations with fish intake. Thus, fish from the Baltic Sea is a major source of exposure to these compounds in Swedes. Polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) had been determined earlier in 29 of the subjects. The PCB contribution to "dioxin-like" effects among high consumers of fish (calculated as Nordic TCDD equivalents) was almost 80%, whereas that from PCDD and PCDF was only 20%.
authors: Institute of Applied Environmental Research, Stockholm University, Solna, Sweden.
authors: L
authors: L
authors: Asplund
authors: B G
authors: BG
authors: Svensson
authors: A
authors: A
authors: Nilsson
authors: U
authors: U
authors: Eriksson
authors: B
authors: B
authors: Jansson
authors: S
authors: S
authors: Jensen
authors: U
authors: U
authors: Wideqvist
authors: S
authors: S
authors: Skerfving
mesh_terms: D000328:Adult; D000818:Animals; D003634:DDT / Q000097:blood*; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood*; D004032:Diet; D005399:Fishes; D005506:Food Contamination; D006801:Humans; D008297:Male; D008875:Middle Aged; D009792:Oceans and Seas; D011078:Polychlorinated Biphenyls / Q000097:blood; D012474:Salmon; D013548:Sweden
chemical_list: D003633:Dichlorodiphenyl Dichloroethylene; D003634:DDT; D011078:Polychlorinated Biphenyls