Prevention of neonatal infections by vaginal chlorhexidine disinfection during labour.
Comparison of two different methods of vaginal disinfection was made with regard to prevention of neonatal infections. In method I, an antepartum vaginal douche with a chlorhexidine solution was used; method II involved the use of chlorhexidine gluconate obstetrical gel during vaginal exploration. We studied 2853 normal deliveries from a total number of 3236 deliveries: 1467 deliveries were allocated randomly to receive a vaginal douche whereas 1386 underwent vaginal exploration using chlorhexidine gel. A total of 203 neonates were transferred to the neonatal unit (120 males and 83 females): 101 belonged to the group where the mothers were subjected to method I, whereas in 102 method II had been used. Within 48 h postpartum 30 neonates from the method I group and 34 neonates from the method II group received systemic antibiotics. There was a tendency towards a higher proportion of full-term neonates with verified septicaemia in the method II group (6 versus 2), whereas the numbers of probable infections were 8 versus 12. The corresponding total numbers in preterm infants were 3 and 2, respectively. These differences were not statistically significant. We conclude that the use of chlorhexidine douche compared with vaginal exploration with chlorhexidine gel provides no additional advantages.
Henrichsen
T
T
Department of Paediatrics, Ullevål Hospital, Oslo, Norway.
Lindemann
R
R
Svenningsen
L
L
Hjelle
K
K
D000282:Administration, Intravaginal; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000503:physiopathology / Q000517:prevention & control*; D001724:Birth Weight; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D036861:Delivery, Obstetric; D004203:Disinfection; D005260:Female; D005782:Gels; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000503:physiopathology / Q000517:prevention & control*; D007363:Intensive Care Units, Neonatal; D008297:Male; D049590:Postpartum Period; D011247:Pregnancy; D012189:Retrospective Studies; D012996:Solutions
D000900:Anti-Bacterial Agents; D005782:Gels; D012996:Solutions; C010882:chlorhexidine gluconate; D002710:Chlorhexidine