Quantitative diagnosis of Schistosoma infections by measurement of circulating antigens in serum and urine.
Recent research on the detection of the schistosome circulating antigens, circulating anodic antigen (CAA) and circulating cathodic antigen (CCA), has greatly expanded the scope of applications. In the present paper aspects of assay development, in particular of highly sensitive assays and of field-applicable assays, are discussed. The progress in the use of CAA- and CCA-detection for diagnosis, follow-up of chemotherapy and sero-epidemiological studies is evaluated.
Deelder
A M
AM
Department of Parasitology, University of Leiden, The Netherlands.
Qian
Z L
ZL
Kremsner
P G
PG
Acosta
L
L
Rabello
A L
AL
Enyong
P
P
Simarro
P P
PP
van Etten
E C
EC
Krijger
F W
FW
Rotmans
J P
JP
D000818:Animals; D000947:Antigens, Helminth / Q000097:blood* / Q000652:urine*; D002986:Clinical Trials as Topic; D004797:Enzyme-Linked Immunosorbent Assay; D015200:Fluoroimmunoassay; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000097:blood* / Q000652:urine*; D015801:Helminth Proteins / Q000097:blood* / Q000652:urine*; D006801:Humans; D012547:Schistosoma / Q000276:immunology*; D012552:Schistosomiasis / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000652:urine*; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies
D000947:Antigens, Helminth; C091532:CCA protein, Schistosoma mansoni; D006023:Glycoproteins; D015801:Helminth Proteins; C090907:circulating anodic antigen, Schistosoma mansoni