title: Elimination studies of antipyrine and its metabolites in healthy Saudi Arabians.
abstract: 1. We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydroxyantipyrine (4-OH AP), norantipyrine (NOR AP) and 3 hydroxymethylantipyrine (3-OHM AP) in 21 subjects. 2. The mean +/- SD of the antipyrine clearance was 2.4 +/- 1.1 h-1 (range 1.0-5.5 l h-1) and the corresponding value per kg body weight was 0.6 +/- 0.2 ml min-1 kg-1. Urinary excretion of antipyrine (AP), 4-OH AP, NOR AP and 3-OHM AP expressed as a percentage of the oral dose of antipyrine given was 2.8 +/- 2.2, 14.5 +/- 6.9, 12.3 +/- 5.6 and 7.6 +/- 3.2 respectively. 3. Compared to Africans, Saudis preferentially metabolize AP to NOR AP and compared to Caucasians to 3-OHM AP, rather than to 4-OH AP. These discrepancies may reflect age differences between the study populations rather than genetic or ethnic variations.
authors: Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors: H A
authors: HA
authors: Ali
authors: A
authors: A
authors: el-Yazigi
authors: J O
authors: JO
authors: Sieck
authors: M
authors: M
authors: Døssing
authors: J
authors: J
authors: Saour
authors: D A
authors: DA
authors: Raines
authors: P
authors: P
authors: Ernst
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000652:urine; D044466:Asian People; D044383:Black People; D002851:Chromatography, High Pressure Liquid; D000077553:Edaravone; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D012529:Saudi Arabia; D044465:White People
chemical_list: C007983:4-hydroxyantipyrine; C031820:3-hydroxymethylantipyrine; D000077553:Edaravone; D000983:Antipyrine