[Low-dose continuous infusion therapy 5-FU and CDDP enabled terminal patients with lung and rectal cancer to remain at home].
CDDP and 5-FU are time dependent drugs and their increasing effect is expected because of the dual chemical modulation. The low dose continuous infusion of CDDP and 5-FU was applied to the terminal adenocarcinoma patients with the metastatic lesions. One patient was 42 years old lung cancer patient with the metastatic lesions in the liver, the bone, the pericardial space, the underskin, the muscles and the lymph nodes (stage IV). The another patient was 61 years old rectum cancer patient with lung and hepatic metastasis (stage V). Both patients were directly informed of the true name of the disease and the poor curability from the physician in charge. The physician promised them to take the home therapy as much as possible in order to pursuit their own life value at home. The lung cancer patient got the radiotherapy first to remove the bone pain and the rectum cancer patient was operated to make the stoma to avoid the obstructive ileus beforehand. After the therapy, two patients took the low dose continuous infusion of CDDP and 5-FU. In both cases, the abdominal symptoms such as nausea and vomiting due to the therapy were not recognized and the hematopoietic disorders and the renal failure were slight, so they could get the therapy continuously for very long. The lung cancer patient lived 9 months after the diagnosis and the low dose infusion chemotherapy has continued for 7 months, the home stay for 4 months. The rectum cancer patient lived 13 months and the same chemotherapy has continued for 12.5 months, the home stay for 7.5 months. The low dose continuous infusion therapy of CDDP and 5-FU is an effective treatment for terminal cancer patients as one of the home therapies from the point of the QOL (quality of life).
Hayashi
K
K
Dept. of Internal Medicine, Hoshigaoka Koseinenkin Hospital.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D018575:Home Care Services, Hospital-Based; D018718:Home Infusion Therapy; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy*; D013727:Terminal Care
D002945:Cisplatin; D005472:Fluorouracil