[Study on Na(+)-K(+)-ATPase of the spiral ganglion neuron and acetylcholinesterase of the cochlea efferent nerve after electric stimulation in the scale media].
In this study, it was found the concentration of Na(+)-K(+)-ATPase of the spiral ganglion neuron (SGN) increased 3 months after electric stimulation (0.1 mA) for 3 hours. However, current at 1.0 mA would destroy the enzyme production mechanism of SGN. Therefore 0.4 mA might be thought as a critical level because the concentration of the enzyme decreased with just above this level of stimulation. We suggest that the appropriate intensity range of the current stimulation of SGN should be controlled from 0.1 mA-0.4 mA. Acetylcholinesterase of the cochlea efferent nerve would increase with weak current stimulation (0.1 mA) which might play an important role in the protection of SGN during ototoxicity. This experimental results led to the conclusion that Na(+)-K(+)-ATPase of the SGN could be taken as an objective indicator presenting the functional changes of SGN quantitatively.
Wang
Z
Z
EENT Hospital of Shanghai Medical University.
Shen
Y
Y
Shen
Y
Y
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D003056:Cochlear Nerve / Q000201:enzymology*; D004525:Efferent Pathways; D004558:Electric Stimulation; D006168:Guinea Pigs; D009474:Neurons / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013136:Spiral Ganglion / Q000201:enzymology*
D000110:Acetylcholinesterase; D000254:Sodium-Potassium-Exchanging ATPase