title: Proliferative effects of humoral factors derived from neuroblastoma cells on cultured astrocytes.
abstract: The proliferative effects of humoral factors released from N18-RE105 neuroblastoma (NRE) cells on cultured astrocytes were assessed in separate co-culture and conditioned medium studies. In both experimental conditions, the humoral factors derived from neuroblastoma cells had growth-promoting effects on C6 glioma cells of astroglial lineage, but not on primary cultured astrocytes from new-born rat cerebral cortex. It is assumed that neuron-derived humoral factors include astroglial growth factors and that differences in responsiveness between two kinds of cells are probably related to the stages of astroglial maturation processes.
authors: Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan.
authors: M
authors: M
authors: Ohashi
authors: S
authors: S
authors: Amano
authors: F
authors: F
authors: Hazama
authors: J
authors: J
authors: Handa
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D017077:Culture Media, Conditioned; D051379:Mice; D009447:Neuroblastoma / Q000378:metabolism*; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D017077:Culture Media, Conditioned