Heart fatty acid binding protein is a novel regulator of cardiac myocyte hypertrophy.
Heart fatty acid binding protein (H-FABP) is a 15kDa protein that mediates the passage of fatty acids from the plasma membrane to sites of lipid synthesis. We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis and c-jun expression. A high affinity receptor for H-FABP has also been identified. Taken together, these data suggest that H-FABP may participate in the regulation of cardiac myocyte growth and differentiation.
Burton
P B
PB
Dept. of Paediatric Cardiology, UMDS, Guys Hospital, London, UK.
Hogben
C E
CE
Joannou
C L
CL
Clark
A G
AG
Hsuan
J J
JJ
Totty
N F
NF
Sorensen
C
C
Evans
R W
RW
Tynan
M J
MJ
D000818:Animals; D001665:Binding Sites; D006332:Cardiomegaly / Q000209:etiology* / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D048429:Cell Size / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D007700:Kinetics; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism*; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D011487:Protein Conformation; D051381:Rats
D002352:Carrier Proteins; C490174:Fabp7 protein, rat; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins