[Spinal cord injuries: comments on preventive and curative strategy].
Research for the cure for paralysis caused by spinal cord injury has followed three complementary lines: Limitation of secondary lesions; the use of antagonists of excitatory amino acids has proven affective in reducing the extent of the lesions. Control of the glial scar; an oxygenated derivative of cholesterol can reduce the proliferation of reactive astrocytes and their hypertrophy, and permit the regrowth of axons in a denervated territory. Transplantation of embryonic neurons below the lesion allows to reinnervate denervated sites and reestablish reflex functions.
Privat
A
A
336 INSERM-USTL Montpellier.
Pencalet
P
P
Gimenez-Ribotta
M
M
Mersel
M
M
Rajaofetra
N U
NU
D006801:Humans; D011379:Prognosis; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000628:therapy*; D013997:Time Factors
Lésions médullaires traumatiques: réflexions sur une stratégie préventive et curative.