title: On the pathogenesis of IDDM.
abstract: A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2- and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.
authors: Steno Diabetes Center, Gentofte, Denmark.
authors: J
authors: J
authors: Nerup
authors: T
authors: T
authors: Mandrup-Poulsen
authors: S
authors: S
authors: Helqvist
authors: H U
authors: HU
authors: Andersen
authors: F
authors: F
authors: Pociot
authors: J I
authors: JI
authors: Reimers
authors: B G
authors: BG
authors: Cuartero
authors: A E
authors: AE
authors: Karlsen
authors: U
authors: U
authors: Bjerre
authors: T
authors: T
authors: Lorenzen
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D003718:Denmark; D003920:Diabetes Mellitus / Q000266:history; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000503:physiopathology*; D005060:Europe; D049673:History, 20th Century; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D007515:Islets of Langerhans / Q000473:pathology* / Q000503:physiopathology / Q000648:ultrastructure; D008954:Models, Biological; D009569:Nitric Oxide / Q000633:toxicity; D017472:Receptors, Interleukin-1 / Q000502:physiology; D012955:Societies, Medical; D013481:Superoxides / Q000633:toxicity
chemical_list: D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D013481:Superoxides; D009569:Nitric Oxide