Renal sodium-phosphate cotransport.
Proximal tubular reabsorption of inorganic phosphate (P(i) is a major determinant of the extracellular concentration of phosphate. The net proximal reabsorption of phosphate largely depends on the rate of apical sodium-dependent transport of P(i) (Na/P(i) cotransport), which is controlled by various hormonal and nonhormonal factors. Renal Na/P(i) cotransport systems that represent proximal apical Na/P(i) cotransport systems have recently been identified. Molecular knowledge of proximal tubular Na/P(i) cotransport will lead to a new understanding of the cellular mechanisms of the physiologic control of proximal P(i) reabsorption and to elucidation of the pathophysiologic mechanisms impairing P(i) homeostasis.
Murer
H
H
Institute of Physiology, University of Zürich, Switzerland.
Biber
J
J
D000818:Animals; D002352:Carrier Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003001:Cloning, Molecular; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D050608:Sodium-Phosphate Cotransporter Proteins; D027981:Symporters
D002352:Carrier Proteins; D008565:Membrane Proteins; D050608:Sodium-Phosphate Cotransporter Proteins; D027981:Symporters