title: Effect of magnesium administered during postischemic reperfusion on myocardial oxidative metabolism in isolated rat hearts.
abstract: To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfusion. Untreated postischemic hearts exhibited after 15 minutes of reperfusion recovery of myocardial oxygen consumption to 65% of the preischemic value despite persistent depression of left ventricular isovolumic pressure development to 21%. Magnesium (15 mM) administered during the initial 30 minutes of reperfusion reduced myocardial oxygen consumption of reperfuse myocardium by 35%. Oxidation of [1-14C]palmitate was slightly more reduced (-55%) than oxidation of [U-14C]glucose (-42%). Magnesium did not influence ultimate recovery of contractile function and cumulative myocardial release of creatine kinase. Thus, 15 mM magnesium administered during reperfusion elicited a reduction of oxidative metabolism. However, magnesium did not modify myocardial injury.
authors: Cardiology Center, University Hospital, Geneva, Switzerland.
authors: C
authors: C
authors: Tamm
authors: I
authors: I
authors: Papageorgiou
authors: I
authors: I
authors: Tardy
authors: B
authors: B
authors: Mermillod
authors: W
authors: W
authors: Rutishauser
authors: R
authors: R
authors: Lerch
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects*; D010168:Palmitates / Q000378:metabolism; D051381:Rats
chemical_list: D010168:Palmitates; D008274:Magnesium; D005947:Glucose