title: [An unusual constellation of findings in polymyositis--differential diagnosis and clinical course].
abstract: Clinical and biochemical findings are described in a 34-year-old female with atypical polymyositis. Uncommon clinical features in this patient included distally accented decreased muscle strength and myalgias, atypical electromyographic findings, a remarkable discrepancy between clinical findings and laboratory parameters of myolysis, unexplained episodes of somnolism, presence of increased serum lactate levels, and a unilateral mamma aplasia. For this combination of signs a polymyositis or an inclusion body myositis, but also a metabolic or heredodegenerative myopathy was considered. Finally, the idiopathic polymyositis was confirmed histologically and a marked improvement in the clinical and biochemical signs occurred after commencement of high-dose methylprednisolone.
authors: Medizinische Universitätsklinik III und Poliklinik, Charité, Humboldt-Universität zu Berlin.
authors: F
authors: F
authors: Buttgereit
authors: J
authors: J
authors: Janda
authors: M
authors: M
authors: Egert
authors: F
authors: F
authors: Hiepe
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D007958:Leukocyte Count / Q000187:drug effects; D017241:MELAS Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D008775:Methylprednisolone / Q000008:administration & dosage; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology; D009136:Muscular Dystrophies / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D017285:Polymyositis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D007773:Lactates; D019344:Lactic Acid; D008775:Methylprednisolone
vernacular_title: Ungewöhnliche Befundkonstellation bei Polymyositis--Differentialdiagnostik und klinischer Verlauf.