[Oligodeoxyribonucleotides containing 1-(beta-D-3'-deoxy-threo-pentofuranosyl)pyrimidine chains].
Effective methods of multiple incorporations of nucleotides with the inverted configuration of C2' hydroxyl group have been developed. The presence of tU and tC as 3'-terminal oligonucleotide modifications is shown to increase their resistance to snake venom phosphodiesterase. The obtained compounds are promising for the use in antisense biotechnology.
Oretskaia
T S
TS
Ibragim
Kh K
KhK
Volkov
E M
EM
Romanova
E A
EA
Tashlitskiĭ
V N
VN
Shabarova
Z A
ZA
D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011743:Pyrimidines / Q000032:analysis*
D009838:Oligodeoxyribonucleotides; D011743:Pyrimidines
Oligodezoksiribonukleotidy, soderzhashchie 1-(beta-D-3'-dezoksi- treo-pentofuranozil)pirimidinovye zven'ia.