Effects of Panax notoginseng saponins on myocardial adenosinetriphosphatase.
Effects of total Panax notoginseng saponins (PNS) and Panax notoginseng saponin monomers Rb1 and Rg1 (Rb1, Rg1) on total ATPase and Na(+)-K(+)-exchanging ATPase of guinea pig heart were studied. It was found that PNS inhibited the total myocardial ATPase, but had no significant effect on the myocardial Na(+)-K(+)-exchanging ATPase. The total ATPase was inhibited by Rg1, and more clearly by Rb1. The automaticity and contractility of isolated guinea pig atria were inhibited by Rb1. Rg1 decreased the spontaneous frequency of isolated guinea pig right atrium, but not markedly the contractility of the left atrium. These results demonstrate that Rb1 is the main ingredient in PNS.
Chen
J Q
JQ
Department of Pathophysiology, Guilin Medical College, China.
Zhang
Y G
YG
Li
S L
SL
Zeng
Q
Q
Rong
M Z
MZ
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D012503:Saponins; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase