title: Total synthesis of ardisiaquinone A, a potent 5-lipoxygenase inhibitor, isolated from Ardisia sieboldii, and degree of 5-lipoxygenase inhibitory activity of its derivatives.
abstract: Ardisiaquinone A (1), isolated as a potent 5-lipoxygenase inhibitor from the woods of Ardisia sieboldii, has been synthesized efficiently via a cross-coupling reaction between the yne 5 and the iodide 6 derived from the common intermediate 4. Inhibitory activity for 1 and its derivatives is also reported.
authors: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors: Y
authors: Y
authors: Fukuyama
authors: Y
authors: Y
authors: Kiriyama
authors: M
authors: M
authors: Kodama
authors: H
authors: H
authors: Iwaki
authors: S
authors: S
authors: Hosozawa
authors: S
authors: S
authors: Aki
authors: K
authors: K
authors: Matsui
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D003432:Cross-Linking Reagents; D006168:Guinea Pigs; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D016227:Benzoquinones; D003432:Cross-Linking Reagents; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D011809:Quinones; C091304:ardisiaquinone A