Healing of rickets during vitamin D therapy despite defective vitamin D receptors in two siblings with vitamin D-dependent rickets type II.
We report the healing of severe rickets despite hypocalcemia in two siblings with absent vitamin D receptors; long periods of treatment with excessive doses of vitamin D led to relative hypoparathyroidism and a return to normal of calcium metabolism during calcitriol treatment. This finding suggests that some other regulating factor may substitute for the defective vitamin D receptor.
Kruse
K
K
Department of Pediatrics, University of Luebeck and Neunkirchen, Germany.
Feldmann
E
E
D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000209:etiology; D007015:Hypophosphatemia, Familial / Q000188:drug therapy*; D007223:Infant; D008297:Male; D018167:Receptors, Calcitriol / Q000502:physiology*; D014807:Vitamin D / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D018167:Receptors, Calcitriol; D014807:Vitamin D