title: Ultrasound-guided injection of methotrexate versus laparoscopic salpingotomy in ectopic pregnancy.
abstract: OBJECTIVE
  To compare local injection of methotrexate (MTX) under sonographic control to laparoscopic salpingotomy for conservative management of ectopic pregnancy (EP).
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  Forty patients were randomized into two groups using a random number table. Inclusion criteria were an EP visualized by ultrasound with a pretherapeutic score < or = 13 as assessed by six criteria graded from 1 to 3: gestational age, hCG level, P level, abdominal pain, volume of the hemoperitoneum, and diameter of the hematosalpinx.
  
  
  METHODS
  Group 1 patients injected transvaginally with 1 mg/kg MTX into the EP without anesthesia versus group 2 patients undergoing laparoscopic salpingotomy.
  
  
  METHODS
  Postoperative hospital stay, decrease of hCG levels, success rate.
  
  
  RESULTS
  The success rates, defined by hCG levels returned to normal (< 10 mIU/mL [conversion factor to SI units, 1.00]), were 19 of 20 in both groups. Medical treatment was associated significantly with shorter postoperative stay (24 versus 46 hours) and a higher initial hCG level. Human chorionic gonadotropin returned to normal more quickly after laparoscopic treatment (14 versus 28 days).
  
  
  CONCLUSIONS
  In selected cases of EP with a pretherapeutic score < or = 13, MTX treatment appeared to be as safe and efficient as was conservative treatment by laparoscopy.
authors: Department of Obstetrics and Gynecology, Hôpital Antoine Beclere, Clamart, France.
authors: H
authors: H
authors: Fernandez
authors: S
authors: S
authors: Pauthier
authors: S
authors: S
authors: Doumerc
authors: C
authors: C
authors: Lelaidier
authors: F
authors: F
authors: Olivennes
authors: Y
authors: Y
authors: Ville
authors: R
authors: R
authors: Frydman
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006801:Humans; D007047:Hysterosalpingography; D007267:Injections; D010535:Laparoscopy; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000628:therapy*; D011446:Prospective Studies; D012489:Salpingostomy; D014463:Ultrasonography; D014621:Vagina
chemical_list: D006063:Chorionic Gonadotropin; D008727:Methotrexate