Malignant mixed Müllerian tumors of the uterus.
OBJECTIVE
To review the prognostic factors of Chinese women with mixed Müllerian tumors of the uterus.


METHODS
A retrospective review of 21 cases of malignant mixed Müllerian tumors of the uterus treated during the 10-year period from 1980 to 1990.


RESULTS
All patients except one were postmenopausal. The incidence of previous pelvic irradiation was 9.5%. The most common presenting symptom was abnormal vaginal bleeding. One-third of patients yielded an abnormal cervical smear. Treatment included surgery, chemotherapy and radiotherapy in the majority of patients. Prognosis was poor with only three long-term survivors, all with stage-I homologous tumors with superficial myometrial invasion. The survival rate for stage-I and -II disease at 2 years was 50% and for more advanced disease extending beyond the uterus was 0%. The survival rate for all stages at 5 years was 14.3%, and the cumulative probability of survival at 5 years was 0.165.


CONCLUSIONS
The most important prognostic factors appear to be the extent of tumor involvement at the time of diagnosis and the depth of myometrial invasion.
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W W
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Department of Obstetrics and Gynecology, University of Hong Kong, Queen Mary Hospital.
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H Y
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D003131:Combined Modality Therapy; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015993:Life Tables; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000401:mortality* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000401:mortality* / Q000628:therapy