title: New chlorine-containing prenylated C6-C3 compounds increasing choline acetyltransferase (ChAT) activity in culture of postnatal rat septal neurons from Illicium tashiroi.
abstract: The structures of two new chlorine-containing C6-C3 compounds isolated from the woods of Illicium tashiroi have been established as 2(R)-12-chloro-2,3-dihydroillicinone E (1) and 12-chloroillicinone E (2) by X-ray crystallographic analysis and spectroscopic data, respectively. Compound 1 has been found to significantly increase ChAT activity in culture of P10 rat septal neurons.
authors: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors: Y
authors: Y
authors: Fukuyama
authors: K
authors: K
authors: Okamoto
authors: Y
authors: Y
authors: Kubo
authors: N
authors: N
authors: Shida
authors: M
authors: M
authors: Kodama
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004149:Dioxoles / Q000302:isolation & purification* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D012686:Septal Nuclei / Q000166:cytology; D013329:Structure-Activity Relationship
chemical_list: C091303:12-chloro-2,3-dihydroillicinone E; C091302:12-chloroillicinone E; D001572:Benzofurans; D004149:Dioxoles; D010936:Plant Extracts; D002795:Choline O-Acetyltransferase