Nitric oxide donors preferentially inhibit neuronally mediated rat gastric acid secretion.
Continuous i.v. infusion of the nitric oxide (NO) donors, S-nitroso-glutathione (10-50 micrograms kg-1 min-1) and S-nitroso-N-acetyl-penicillamine (10 micrograms kg-1 min-1) inhibited neuronally mediated gastric acid secretion, as induced by gastric distension (20 cm water) or i.v. bolus administration of 2-deoxy-D-glucose (150 mg kg-1) in the anaesthetized rat. By contrast, gastric acid responses to i.v. infusion of submaximal doses of pentagastrin (8 micrograms kg-1 h-1) or histamine (1 mg kg-1 h-1) were not influenced by these NO donors. These findings suggest that NO does not directly influence acid secretion in vivo but could play an inhibitory modulator role in neuronally mediated acid responses.
Barrachina
D
D
Departamento de Farmacología, Facultad de Medicina, Universidad de Valencia, Spain.
Calatayud
S
S
Esplugues
J
J
Whittle
B J
BJ
Moncada
S
S
Esplugues
J V
JV
D000818:Animals; D003847:Deoxyglucose / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005978:Glutathione / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D009603:Nitroso Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D010396:Penicillamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D026423:S-Nitroso-N-Acetylpenicillamine; D026422:S-Nitrosoglutathione; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D009603:Nitroso Compounds; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; D026423:S-Nitroso-N-Acetylpenicillamine; D006632:Histamine; D003847:Deoxyglucose; D010418:Pentagastrin; D005978:Glutathione; D010396:Penicillamine