Hypersensitivity and cross-reactivity to cisplatin and analogues.
We report on a 49-year-old woman with relapsing ovarian cancer who developed a hypersensitivity reaction (HSR) to carboplatin and, subsequently, to cisplatin. This patient was known to be allergic to Co-Amoxiclav and talc, both giving rise to a transient macular skin rash, but had no other history of atopy. Similar cases, including some of life-threatening severity, have been reported in the literature. These severe reactions may prevent a small population of young patients from receiving effective therapy with cisplatin or its analogues, treatment known to be associated with a significant improvement in survival in germ-cell tumours, ovarian cancer and osteogenic sarcoma.
Shlebak
A A
AA
Department of Haematology, Glasgow Royal Infirmary, UK.
Clark
P I
PI
Green
J A
JA
D016190:Carboplatin / Q000009:adverse effects* / Q000276:immunology; D002945:Cisplatin / Q000009:adverse effects* / Q000276:immunology; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy
D016190:Carboplatin; D002945:Cisplatin