[NK cells and their characteristics and immunogenetic aspects].
This review summarizes knowledge of history and development of the "new" biological phenomenon. NK cells play a pivotal role in immune surveillance against tumors and virus-infected cells. They are also involved in natural resistance to bone marrow transplantations and in the regulation of the growth and activity of immunocompetent and hematopoietic cells. Unlike cytotoxic T lymphocytes NK cell activity is not dependent on thymus maturation and an expression of class I MHC antigens. They lack immunological memory and develop directly from precursor cells of the bone marrow. The lytic activity of NK cells is associated with the population of large granular lymphocytes (LGL). In human peripheral blood there is about 5% of LGL. A great deal of the study is given to still actual about the possible role of class I MHC antigen expression in regulation of NK-cell cytotoxicity. (Fig. 1, Tab. 2, Ref. 118).
Tóth
J
J
Imunologický ústav LFUK v Bratislave, Slovakia.
D000818:Animals; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology*
NK-bunky a ich charakteristika a imunogenetické aspekty.