Evaluation of the expression of tissue DF-3 and MCA and the corresponding serum values in patients with breast carcinoma.
Two specific monoclonal antibodies for breast tissue (DF3 and MCAb-12) and the corresponding tumor markers CA15-3 and MCA in serum have been evaluated in 50 patients with breast cancer and in 15 controls. The expression of these antigens in tissue was poorly correlated with the common prognostic parameters. Their presence in serum was associated with an altered distribution of the antigens in the cell. The expression of these antigens in tissue enables us to select patients for serological follow-up and to evaluate tumor differentiation from a functional point of view.
Giovagnoli
M R
MR
Department of Experimental Medicine, University, La Sapienza, Roma, Italy.
Reale
G
G
Cosentino
L
L
Manna
A
A
Midulla
C
C
Marchei
G
G
Vecchione
A
A
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D018396:Mucin-1 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D018396:Mucin-1; C057387:mucinous carcinoma-associated antigen