Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease.
The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four control subjects and four patients with dementia of the Alzheimer type (DAT). Neuronal counts on sections stained with silver and a polyclonal antibody to human choline acetyltransferase (ChAT) revealed an undiminished number of LVN neurons in patients with DAT. Numerous silver-stained neurofibrillary tangles (NFTs) were found in the DAT group, some also in the LVN of controls. These findings suggest that DAT affects LVN neurons, however without causing neuronal loss.
Ransmayr
G
G
Department of Neurology, University Hospital, Innbruck, Austria.
Benesch
H
H
Nowakowski
C
C
Künig
G
G
Heinsen
H
H
Riederer
P
P
Hersh
L B
LB
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001933:Brain Stem / Q000201:enzymology / Q000473:pathology; D002452:Cell Count; D002795:Choline O-Acetyltransferase / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis; D016874:Neurofibrillary Tangles / Q000473:pathology*; D009474:Neurons / Q000201:enzymology / Q000473:pathology*; D016622:Silver Staining; D014726:Vestibular Nuclei / Q000201:enzymology / Q000473:pathology*
D009419:Nerve Tissue Proteins; D002795:Choline O-Acetyltransferase