title: Khusimol, a non-peptide ligand for vasopressin V1a receptors.
abstract: In the course of a random screen of various plant extracts, khusimol [1], a non-peptide molecule isolated from the root of Vetiveria zizanioides, was found to competitively inhibit the binding of vasopressin to rat liver V1a receptors (Ki = 50 microM). The 1H- and 13C-nmr spectra of this sesquiterpene alcohol were assigned unambiguously.
authors: Sanofi Recherche, Toulouse, France.
authors: R C
authors: RC
authors: Rao
authors: C
authors: C
authors: Serradeil-Le Gal
authors: I
authors: I
authors: Granger
authors: J
authors: J
authors: Gleye
authors: J M
authors: JM
authors: Augereau
authors: C
authors: C
authors: Bessibes
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D066298:In Vitro Techniques; D008024:Ligands; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D051381:Rats; D017483:Receptors, Vasopressin / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D008024:Ligands; D000081223:Polycyclic Sesquiterpenes; D017483:Receptors, Vasopressin; D012717:Sesquiterpenes; D001127:Arginine Vasopressin; C091305:khusimol