title: The relationship between learning performance and dopamine in the prefrontal cortex of the rat.
abstract: To clarify the relationship between dopamine (DA) release in the prefrontal cortex and learning performance, extracellular DA was measured by an in vivo microdialysis method during a discrimination learning task. Rats were trained to discriminate between lamp-on and -off states under an operant-type learning procedure. After stable discriminative behavior was established, a microdialysis experiment was conducted. Inverse relationships were seen between the relative ratio of DA after the beginning of a learning session to the basal level and the responses (total, correct and error responses) during a session. The results indicate that the degree of DA release in the prefrontal cortex is involve in the inhibitory mechanism of the response during discrimination learning performance.
authors: Department of Physiology, Saitama Medical School, Japan.
authors: Y
authors: Y
authors: Yamamuro
authors: K
authors: K
authors: Hori
authors: H
authors: H
authors: Iwano
authors: M
authors: M
authors: Nomura
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D004192:Discrimination, Psychological / Q000502:physiology*; D004298:Dopamine / Q000032:analysis / Q000378:metabolism*; D005110:Extracellular Space / Q000737:chemistry; D005625:Frontal Lobe / Q000737:chemistry / Q000502:physiology*; D006719:Homovanillic Acid / Q000032:analysis; D007858:Learning / Q000502:physiology*; D008297:Male; D017551:Microdialysis; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid