A lymphotropic colloidal carrier system for diethylcarbamazine: preparation and performance evaluation.
Targeting to organs other than the RES-bearing organs is difficult to achieve. A nanoparticle-based emulsion delivery system was prepared and its efficacy in enhancing the lymphatic uptake of the anti-filarial drug diethylcarbamazine was evaluated. It was compared with a simple w/o emulsion and a control aqueous solution. The effect of route of administration on the lymphatic uptake was studied and it was found that the i.p. route gave better results as compared to the i.v. route, in which total lack of lymphatic uptake was observed. The nanoparticle-in-oil emulsion system holds excellent potential as a lymphotropic carrier system.
Karajgi
J S
JS
Project Laboratory, Department of Pharmaceutical Sciences, Sagar, India.
Vyas
S P
SP
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003102:Colloids / Q000008:administration & dosage / Q000493:pharmacokinetics; D004049:Diethylcarbamazine / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D005780:Gelatin / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D012157:Mononuclear Phagocyte System / Q000378:metabolism; D010316:Particle Size; D010587:Phagocytosis; D051381:Rats
D003102:Colloids; D004337:Drug Carriers; D005780:Gelatin; D004049:Diethylcarbamazine