Clozapine treatment of polydipsia.
A patient with refractory chronic schizophrenia having severe polydipsia and hyponatremia was treated with clozapine. There followed a dramatic improvement in the polydipsia and correction of the hyponatremia. This improvement has been sustained throughout a 6-month follow-up.
Gupta
S
S
University of Iowa College of Medicine, Mental Health Clinical Research Center, Iowa City 52242-1057.
Baker
P
P
D000328:Adult; D002908:Chronic Disease; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D003192:Compulsive Behavior / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004334:Drug Administration Schedule; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008609:Mental Status Schedule; D012562:Schizophrenia, Disorganized / Q000188:drug therapy* / Q000235:genetics / Q000523:psychology; D014882:Water-Electrolyte Balance / Q000187:drug effects
D003024:Clozapine