Cholesterol treatment facilitates spatial learning performance in DBA/2Ibg mice.
DBA/2Ibg mice were treated with cholesterol pellets for 11 days. On the seventh day after treatment, animals began 5 consecutive days of training on the spatial form of Morris water task, followed on the third and fourth days by a probe trial, and random platform training on the fifth day. DBA mice with cholesterol pellets exhibited enhanced performance compared to DBA mice that underwent a sham surgery. Our results suggest that subchronic treatment with the steroid hormone precursor, cholesterol, enhances spatial learning performance in DBA mice.
Miller
S
S
Institute for Behavioral Genetics, University of Colorado, Boulder 80309-0447.
Wehner
J M
JM
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D008811:Mice, Inbred DBA; D013028:Space Perception / Q000187:drug effects*; D013268:Stimulation, Chemical
D002784:Cholesterol