title: Scedosporium prolificans sclerokeratitis.
abstract: BACKGROUND
  The fungus Scedosporium prolificans was first described as a human pathogen in 1984, and has been associated with metastatic endophthalmitis and one previously reported case of sclerokeratitis.
  
  
  METHODS
  We report a case of S. prolificans sclerokeratitis in the setting of late scleral necrosis complicating pterygium surgery with adjunctive beta-irradiation.
  
  
  RESULTS
  A poor clinical response to topical natamycin and amphotericin B, and systemic itraconazole and ketoconazole was encountered. Enucleation was required, with subsequent microbiological cure. Pathological correlation is described.
  
  
  CONCLUSIONS
  S. prolificans infections often respond poorly to medical therapy. Early surgical intervention is indicated in culture-proven scleritis due to Scedosporium prolificans.
authors: University of Melbourne Department of Ophthalmology, Royal Victorian Eye and Ear Hospital.
authors: L J
authors: LJ
authors: Sullivan
authors: G
authors: G
authors: Snibson
authors: C
authors: C
authors: Joseph
authors: H R
authors: HR
authors: Taylor
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D015353:Eye Enucleation; D015821:Eye Infections, Fungal; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008271:Mycetoma; D009336:Necrosis / Q000209:etiology; D011183:Postoperative Complications; D011625:Pterygium / Q000532:radiotherapy / Q000601:surgery; D015423:Scleritis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents