title: Regulation of proteolytic activity in tissues.
abstract: Degradation of tissue proteins is controlled by multiple means. These include regulation of the synthesis of proteinases, activation of the zymogen forms, the activity of the mature proteinase, and the degradation of these enzymes and the substrates. Mature proteinases can be controlled by pH, calcium ions, ATP, lipids and the formation of complexes with other proteinases, proteoglycans, and inhibitors.
authors: Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226.
authors: S S
authors: SS
authors: Twining
mesh_terms: D000595:Amino Acid Sequence; D002451:Cell Compartmentation; D003546:Cysteine Endopeptidases; D010450:Endopeptidases / Q000096:biosynthesis / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D004789:Enzyme Activation; D015971:Gene Expression Regulation, Enzymologic; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes; D011480:Protease Inhibitors / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex
chemical_list: D009097:Multienzyme Complexes; D011480:Protease Inhibitors; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex