Chronic granulocytic leukaemia presenting with an extramedullary T lymphoblastic crisis.
A 33-year-old man presented with hepatosplenomegaly and lymphadenopathy. Bone marrow findings were consistent with Philadelphia-positive accelerated-phase chronic granulocytic leukaemia (CGL). Lymph node histology and immunhistochemistry were diagnostic of T lymphoblastic lymphoma. Molecular studies on lymph node DNA identified rearrangement within the major breakpoint cluster region (M-bcr), indicating a common clonal origin of CGL and the T lymphoblastic lymphoma. We report the second case where extramedullary T lymphoblastic crisis was the presenting feature of CGL.
Jacob
A
A
Department of Haematology, Queen Elizabeth Hospital, Birmingham.
Rowlands
D C
DC
Patton
N
N
Holmes
J A
JA
D000328:Adult; D001752:Blast Crisis / Q000473:pathology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D015465:Leukemia, Myeloid, Accelerated Phase / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*