Which way for drug-mediated immunosuppression?
The basic immunosuppressive protocol involves the use of multiple drugs, each directed at a discrete site in the T-cell activation cascade. The prevailing paradigm regarding the mechanisms of action of immunosuppressants is that they function to prevent allograft rejection by preventing cell activation, proliferation and/or cytokine production. A new hypothesis is that some of the immunosuppressants might function by stimulating the expression of immunosuppressive molecules and/or cells.
Sharma
V K
VK
Rogsin Institute, Department of Transplantation and Extracorporeal Therapy, New York Hospital-Cornell Medical Center, New York 10021.
Li
B
B
Khanna
A
A
Sehajpal
P K
PK
Suthanthiran
M
M
D000818:Animals; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D007166:Immunosuppressive Agents