Comparison of Cryptosporidium parvum and Cryptosporidium wrairi by reactivity with monoclonal antibodies and ability to infect severe combined immunodeficient mice.
Twenty-three monoclonal antibodies raised to Cryptosporidium parvum and 12 raised to C. wrairi reacted with equal intensity with the heterologous species. Despite demonstration of a close immunologic relationship between these two species, C. wrairi did not induce persistent infection in severe combined immunodeficient mice as did C. parvum.
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Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor 48109.
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Perryman
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D000818:Animals; D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan / Q000276:immunology*; D003429:Cross Reactions; D003457:Cryptosporidiosis / Q000276:immunology; D003458:Cryptosporidium / Q000276:immunology* / Q000472:pathogenicity*; D016785:Cryptosporidium parvum / Q000276:immunology / Q000472:pathogenicity; D005260:Female; D051379:Mice; D016513:Mice, SCID
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan