title: Cardiac baroreflex sensitivity and sodium excretion are reduced both by a deficit and an excess of dietary salt in the conscious dog.
abstract: In 10 conscious, chronically instrumented beagle dogs we studied the effects of four different dietary sodium intakes (mmol Na/kg body wt/day: 14.5 [excess], 7.5 [high], 2.5 [normal], and 0.5 [low] [plus an additional standardized sodium depletion produced by peritoneal dialysis several days before the experiments]) on cardiac baroreflex sensitivity and renal response to an acute saline load. Full sigmoid barocurves were produced by intravenous injection of phenylephrine (2.5 to 20 micrograms/kg) and nitroglycerine (2.5 to 30 micrograms/kg). The gain of this relationship was significantly decreased by both an excess and low sodium intake (8.0 +/- 1.0 and 8.3 +/- 0.8 beats/min/mm Hg, respectively) when compared with the 2.5 and 7.5 (12.1 +/- 1.4 and 16.0 +/- 1.7 beats/min/mm Hg, respectively) mmol Na/kg/day sodium intake. Water and sodium excretion in response to saline infusion were lower in the 0.5 and 14.5 mmol/kg/day sodium intake groups in spite of the higher atrial natriuretic peptide and lower plasma renin activity and plasma aldosterone levels in the latter. Mean arterial blood pressure, heart rate, and central venous pressure increased during saline loading in all groups; hematocrit and plasma protein concentration decreased similarly in all groups. The results suggest that the rapid renal homeostatic response to an acute salt load in animals kept chronically on normal or moderately increased dietary sodium intake is regulated by baroreflex control of the renal homeostatic response. Excess dietary sodium intake attenuates baroreflex sensitivity and delays sodium and water excretion after acute loading.
authors: AG Experimentelle Anästhesie, UKRV-Charlottenburg, Freie Universität Berlin, Germany.
authors: G
authors: G
authors: Kaczmarczyk
authors: L
authors: L
authors: Koch
authors: R
authors: R
authors: Mohnhaupt
authors: T
authors: T
authors: Vogel
authors: M
authors: M
authors: Weinstock
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D004039:Diet, Sodium-Restricted; D004285:Dogs; D005260:Female; D006329:Heart Conduction System / Q000502:physiology*; D006728:Hormones / Q000097:blood; D009318:Natriuresis / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D006728:Hormones; D012965:Sodium Chloride