title: Carcinomas of the colon with multidirectional differentiation. Report of two cases and review of the literature.
abstract: Two cases of colonic carcinomas with multidirectional differentiation are presented. Both tumors showed light microscopic and immunohistochemical evidence of areas of adenocarcinomatous, squamous cell carcinomatous, and neuroendocrine differentiation. Only six similar cases have been previously reported. These highly malignant tumors support the recent concept of a multipotential stem cell within the mucosa of the gastrointestinal tract capable of differentiation in several directions.
authors: Department of Gastroenterology, Institut Gustave-Roussy, Villejuif, France.
authors: P
authors: P
authors: Novello
authors: P
authors: P
authors: Duvillard
authors: S
authors: S
authors: Grandjouan
authors: D
authors: D
authors: Elias
authors: P
authors: P
authors: Rougier
authors: C
authors: C
authors: Bognel
authors: M
authors: M
authors: Prade
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged