[Influence of endothelin-1 on ventricular fibrillation threshold in acute myocardial ischemic rats].
The influence of endothelin-1 on ventricular fibrillation threshold was studied in acute myocardial ischemic rats. Endothelin-1 (1.5-3.0 micrograms.kg-1 i.v.) given 5 min before ischemia reduced the ventricular fibrillation threshold in a dose- and time-dependent manner. Its effect lasted at least 60 min. A marked increase of spontaneous ventricular tachycardia and myocardial infarct size was seen and the arterial blood pressure was at a higher level (18.5-20.1/14.4-15.8 kPa) after 3.0 micrograms.kg-1. Diltiazem prevented partially from reduction of ventricular fibrillation threshold, eliminated completely the vasopressor response and limited the extension of myocardial necrosis induced by endothelin-1.
Zhao
X
X
Department of Physiology, Second Military Medical University, Shanghai, China.
Fu
W J
WJ
Yuan
W J
WJ
Hou
G X
GX
Chen
J G
JG
Xia
J H
JH
Zhu
H N
HN
D000818:Animals; D004110:Diltiazem / Q000627:therapeutic use*; D016232:Endothelins / Q000633:toxicity*; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications; D051381:Rats; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control*
D016232:Endothelins; D004110:Diltiazem