Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat.
We have examined the expression of protein tyrosine phosphatase genes in the embryonic brain of mouse and rat with reverse transcription-polymerase chain reaction. Several receptor and cytoplasmic types of tyrosine phosphatase genes were detected. Among them a novel gene was identified from mouse and rat brain, respectively. The partial amino acid sequences reveal that the new genes found in the developing brain of mouse and rat are homologous each other. Since they retain conserved phosphatase sequences, they may represent a family of protein tyrosine phosphatase gene that is commonly expressed in rodent brain.
Tagawa
M
M
Department of Biochemistry, School of Medicine, Chiba University, Japan.
Shirasawa
T
T
Fujimura
S
S
Sakiyama
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D001921:Brain / Q000196:embryology / Q000201:enzymology*; D016384:Consensus Sequence; D017124:Conserved Sequence; D004247:DNA / Q000032:analysis; D017931:DNA Primers; D005347:Fibroblasts / Q000201:enzymology; D015870:Gene Expression; D005865:Gestational Age; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D016133:Polymerase Chain Reaction / Q000379:methods; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis*; D051381:Rats; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid
D017931:DNA Primers; D004247:DNA; D017027:Protein Tyrosine Phosphatases