title: Genetic analysis of colon cancer susceptibility in mice.
abstract: Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors. Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes. Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q.
authors: Section of Gastroenterology, University of Wisconsin Medical School, Madison 53792.
authors: R F
authors: RF
authors: Jacoby
authors: C
authors: C
authors: Hohman
authors: D J
authors: DJ
authors: Marshall
authors: T J
authors: TJ
authors: Frick
authors: S
authors: S
authors: Schlack
authors: M
authors: M
authors: Broda
authors: J
authors: J
authors: Smutko
authors: R W
authors: RW
authors: Elliott
mesh_terms: D019813:1,2-Dimethylhydrazine; D000818:Animals; D001483:Base Sequence; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000235:genetics*; D003433:Crosses, Genetic; D004127:Dimethylhydrazines; D004195:Disease Models, Animal; D018450:Disease Progression; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D004127:Dimethylhydrazines; D005819:Genetic Markers; D019813:1,2-Dimethylhydrazine