Reinfection with Schistosoma japonicum after treatment with praziquantel in Poyang lake region, China.
The study on reinfection with Schistosoma japonicum after treatment was carried out in a cohort of subjects in a heavy endemic village of Poyang lake region, China. After mass treatment with praziquantel in non-transmission time, detailed observations of water contact were estimated using the mean area of skin exposed daily. One year after treatment, the prevalence of infection in study subjects was 54.48%, returning to 83% of initial prevalence. The peak prevalence occurred the 11-15 year age class, but intensity of exposure also varies with age and that age group supporting the higher prevalence of reinfection had high levels of exposure. Among groups of subjects with a similar exposure stratum, young subjects under the age of 21 years were more heavily reinfected, while no heavy reinfection was observed in adults (> or = 25 years). These observations suggest that subjects in this area slowly acquire an increasing degree of immunity to lighten the intensity of infection with S. japonicum.
Wu
Z
Z
Jiangxi Provincial Institute o Parasitic Diseases, Nanchang, China.
Shaoji
Z
Z
Pan
B
B
Hu
L
L
Wei
R
R
Gao
Z
Z
Li
J
J
Uwe
B
B
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005618:Fresh Water; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011223:Praziquantel / Q000627:therapeutic use*; D015995:Prevalence; D012008:Recurrence; D012554:Schistosomiasis japonica / Q000188:drug therapy* / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D017211:Treatment Failure
D011223:Praziquantel