title: [The mechanism(s) of alpha-(aminoethyl)-gamma-butyrolactone. In vivo studies in mice].
abstract: This paper describes the synthesis of alpha-(dimethylaminoethyl)-gamma, gamma-diphenyl-gamma-butyrolactone 4. The study of convulsions induced, on mice, by this compound could show the existence of antiGABAergic and cholinergic action components, but, unlike the homologous alpha- (dialkylaminomethil)-gamma-butyrolactones (with one -CH2- less on the aminoalkyl chain), no antiglycinergic component was detected. The effects of atropine on the aminolactone 4 induced convulsions (antagonism 5mn and synergy 30 mn after atropine) could suggest an activation of the glutamatergic receptors (NMDA), by indirect stimulation of their glycinergic site, by the aminolactone 4.
authors: Université d'Athènes, Département de Pharmacie, Division de Chimie Pharmaceutique, Panepistimioupoli Zografou, Athènes, Grèce.
authors: N
authors: N
authors: Kolocouris
authors: G
authors: G
authors: Fytas
authors: G B
authors: GB
authors: Foscolos
authors: I
authors: I
authors: Kalliteraki
authors: A
authors: A
authors: Vamvakides
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003292:Convulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice
chemical_list: D003292:Convulsants; D001285:Atropine; D015107:4-Butyrolactone
vernacular_title: Les mechanisme(s) d'une a-(aminoéthyl)-gamma butyrolactone. Etudes in vivo chez la souris.