Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding.
Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on specific [3H]SCH23390 binding to dopamine D1 receptors and [3H]ketanserine binding to serotonin 5-HT2A receptors in the rat brain. Specific binding of both compounds was affected by aging. Long-term administration of KKT resulted in decreases in [3H]SCH23390 binding to the cortex and hippocampus in aged rats, and in decreases in [3H]ketanserine binding to the caudate/putamen in young rats. These results suggest that the changes in dopamine Di and serotonin 5-HT2A receptor binding may be involved in the central effects of KKT.
Ishihara
S
S
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Yamada
K
K
Hayashi
T
T
Hasegawa
T
T
Kameyama
T
T
Morimasa
T
T
Kaneyuki
T
T
Shohmori
T
T
Nabeshima
T
T
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000493:pharmacokinetics; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007650:Ketanserin / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*
D001552:Benzazepines; D004365:Drugs, Chinese Herbal; D017447:Receptors, Dopamine D1; D011985:Receptors, Serotonin; C073747:kamikihi-to; D007650:Ketanserin