Antibiotic prophylaxis for urodynamic testing in patients with spinal cord injury: a preliminary study.
This study was performed in order to: (i) determine the incidence of symptomatic urinary tract infection (UTI) in patients with spinal cord injury after urodynamic testing; (ii) evaluate the role of antibiotic prophylaxis for such a procedure; and (iii) investigate whether pre-existing bacteriuria predisposes to the development of symptomatic UTI after urodynamic testing. Forty patients were prospectively randomized in a double-blind fashion to receive a 3-day oral course of either ciprofloxacin (18 patients) or placebo (22 patients), beginning 2 days prior to the urodynamic procedure. None of 18 (0%) patients who received ciprofloxacin developed symptomatic UTI within 5 days after the procedure compared with three of 22 (14%) subjects randomized to the placebo group; the protective efficacy of antibiotic prophylaxis, however, did not attain statistical significance (P = 0.24). None of the three bacterial isolates that were responsible for symptomatic infection were grown in corresponding urine cultures prior to the procedure. These findings may serve as a pilot for a larger study.
Darouiche
R O
RO
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.
Smith
M S
MS
Markowski
J
J
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000453:epidemiology / Q000517:prevention & control*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013119:Spinal Cord Injuries / Q000503:physiopathology*; D013781:Texas / Q000453:epidemiology; D001743:Urinary Bladder / Q000503:physiopathology; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000517:prevention & control*; D014563:Urodynamics
D002939:Ciprofloxacin