Antidepressant and depressogenic drugs lack consistent effects on hamster circadian rhythms.
The circadian wheel-running rhythm of golden hamsters was monitored during chronic oral treatment with four antidepressants and two potentially depressogenic agents. Desmethylimipramine shortened the circadian period (tau) by 0.1 hour. In contrast, clorgyline lengthened tau by 0.1 hour and delayed light-synchronized wheel-running rhythms by 1.4 hour. Phenelzine, fluoxetine, clonidine, and propranolol did not significantly alter light-entrained phase or free-running period over a range of doses. Other rhythm parameters were also unaffected by antidepressant or depressogenic drugs. These data suggest that mood-altering drugs do not consistently influence circadian rhythms in the hamster.
Klemfuss
H
H
Research Service, Veterans Affairs Medical Center, San Diego, CA 92161.
Kripke
D F
DF
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology*; D003010:Clorgyline / Q000494:pharmacology; D006224:Cricetinae; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D009043:Motor Activity / Q000187:drug effects*; D010624:Phenelzine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*
D000928:Antidepressive Agents; D005473:Fluoxetine; D011433:Propranolol; D003010:Clorgyline; D003000:Clonidine; D010624:Phenelzine; D003891:Desipramine