Vascular toxicity associated with chemotherapy and hormonotherapy.
Vascular complications associated with chemotherapy and hormonotherapy are being reported with increasing frequency. Such vascular toxicity is clinically heterogenous, ranging from asymptomatic venous lesions to fatal hepatic venoocclusive disease of the liver. Putative mechanisms for such toxicity include drug-induced endothelial cell damage, perturbation of the clotting cascade, platelet activation and aggregation, alteration of thromboxane-prostacyclin homeostasis, and dysregulation of cytokines. Better documentation of the incidence and types of vascular toxicity and studies to help elucidate the pathogenesis and management of such toxicity are needed.
Doll
D C
DC
Department of Medicine, Veterans Affairs Medical Center, Columbia, Missouri.
Yarbro
J W
JW
D000743:Anemia, Hemolytic / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D009202:Cardiomyopathies / Q000139:chemically induced; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced; D006728:Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy; D011928:Raynaud Disease / Q000139:chemically induced; D012164:Retinal Diseases / Q000139:chemically induced; D013629:Tamoxifen / Q000009:adverse effects; D013923:Thromboembolism / Q000139:chemically induced; D014652:Vascular Diseases / Q000139:chemically induced*
D000970:Antineoplastic Agents; D006728:Hormones; D013629:Tamoxifen