Induction of the renal pelvic and ureteral carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine in SD/cShi rats with spontaneous hydronephrosis.
We attempted to establish an animal model for renal pelvic and ureteral carcinomas. In Experiment 1, Sprague-Dawley (SD)/cShi and SD/gShi strains of male and female rats and Fischer-344 (F-344)/DuCrj and LEW/Crj strains of male rats, 6 wk old, were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 12 wk and then treated without chemical for 10 wk. Only the SD/cShi strain, which has spontaneous hydronephrosis and hydroureter, showed high incidences of carcinomas in the renal pelvises and ureters, whereas the other strains did not. In Experiment 2, SD/cShi and Crj:CD strains of male and female rats, 6 wk old, were exposed to 0.05% BBN for 20 wk. Both sexes of SD/cShi rats had high incidences of bilateral carcinomas in renal pelvises and/or ureters associated with urinary bladder carcinomas, whereas both sexes of Crj:CD rats had urinary bladder tumors only. These results indicate that the SD/cShi strain may be a suitable animal for the induction of renal pelvic and ureteral carcinomas that appear to depend on urine stagnation secondary to hydronephrosis and hydroureter.
Mori
S
S
Aburahi Laboratories, Shionogi & Co., Ltd., Shiga, Japan.
Hosono
M
M
Machino
S
S
Nakai
S
S
Makino
S
S
Nakao
H
H
Takeuchi
Y
Y
Takeda
R
R
Murai
T
T
Fukushima
S
S
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity*; D002277:Carcinoma / Q000139:chemically induced*; D004195:Disease Models, Animal; D005260:Female; D006869:Hydronephrosis / Q000150:complications*; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007682:Kidney Pelvis / Q000187:drug effects; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D014516:Ureteral Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002085:Butylhydroxybutylnitrosamine