[The characteristics of the anticonflict action of fenazepam in rats selected by the method of forced swimming].
A method of classification of outbred albino rats by means of forced swimming in a tank filled with water and equipped by freely turning wheels was developed. Using this technique a population of albino rats can be divided into three groups: highly active (HA), low active (LA) animals, and rats with intermediate activity. HA animals exhibit stable behaviour in forced swimming and conflict situation paradigms. They are also more sensitive to a benzodiazepine anxiolytic phenazepam in conflict situation test. At the same time, LA rats decrease their activity and are less sensitive to phenazepam. Both groups (LA and HA) are not homogeneous: each of them includes animals demonstrating quite another type of behaviour compared with a majority of rats.
Seredenin
S B
SB
Voronina
T A
TA
Burlakova
E B
EB
Molodavkin
G M
GM
Cherniavskaia
L I
LI
Khorseva
N I
NI
Mdzinarishvili
A L
AL
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D016009:Chi-Square Distribution; D003220:Conflict, Psychological; D004558:Electric Stimulation; D008297:Male; D010146:Pain / Q000503:physiopathology; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012641:Selection, Genetic; D013550:Swimming / Q000502:physiology; D014868:Water Deprivation / Q000502:physiology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
Osobennosti antikonfliktnogo deĭstviia fenazepama u krys, otobrannykh s pomoshch'iu metoda vynuzhdennogo plavaniia.