[Puerperium after threatened premature labor--positive effects of infection screening by determination of CRP in pregnancy].
Silent intrauterine infection as cause of preterm labour should be recognised early by measuring C-reactive protein (CRP) levels in the maternal serum. Ensuing antibiotic therapy may not only cause gestational prolongation, but also has a positive effect on pathology during the puerperal period. Consequently, we examined the rate of infectious puerperal complications of 181 patients who suffered from so-called idiopathic preterm labour. 84 patients showed normal CRP-levels at the onset of tocolysis (< 5 mg/l); an elevated level was found in 97 patients (> 5 mg/l). Patients with elevated CRP-levels and supplemented antibiotic therapy during pregnancy (n = 51) showed significantly fewer symptoms of postpartal endometritis than women with similarly elevated CRP-levels but without antibiotics (n = 46). This effect was not produced when preterm labour was associated with normal CRP-levels. Patients with premature contractions and elevated CRP-values at the onset of tocolysis seem to benefit from the antibiotic therapy during pregnancy because they show reduced infectious complications throughout the puerperal period.
Winkler
M
M
Frauenklinik der Rheinisch-Westfälischen Technischen Hochschule Aachen.
Gellings
R
R
Pütz
I
I
Funk
A
A
Goetz
M
M
D000328:Adult; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000378:metabolism*; D015310:Cefotiam / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004716:Endometritis / Q000097:blood / Q000517:prevention & control*; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007752:Obstetric Labor, Premature / Q000097:blood / Q000517:prevention & control*; D011247:Pregnancy; D011645:Puerperal Infection / Q000097:blood / Q000517:prevention & control*; D015145:Tocolysis
D000900:Anti-Bacterial Agents; D005280:Fenoterol; D004917:Erythromycin; D000667:Ampicillin; D002097:C-Reactive Protein; D015310:Cefotiam
Wochenbett nach drohender Frühgeburt--positive Auswirkungen eines Infektions-Screenings mittels CRP-Bestimmung in der Schwangerschaft.