title: Time course of recovery from pancreatic hypertrophy during partial exclusion of bile-pancreatic juice in rats.
abstract: The time course of recovery from hypertrophied pancreas to the normal size was examined and compared with the time course of normal size pancreas getting hypertrophied in rats. The bile-pancreatic duct was cannulated and bile-pancreatic juice was partly bypassed the proximal intestine. Trypsin and bile salts disappeared from the lumen of proximal quarter of intestine during the first 7 postoperative days; however, these appeared again after the 14th postoperative day and luminal trypsin activity reached 3 to 4 times the control level during the postoperative days 14-56. Conversely, the plasma cholecystokinin (CCK) concentration significantly increased on day 7, then declined thereafter, and the mRNA level of CCK in the proximal intestinal mucosa increased and reached the maximal level on day 7. Pancreatic wet weight, as an index of size, was significantly increased and remained high on postoperative days 7-28, then returned to the control size on day 56. Therefore, it took 7 d for the pancreas to become hypertrophied by high circulating CCK, however the pancreatic size recovered to the normal size on the 56th postoperative day although the plasma CCK level decreased with the appearance of luminal bile salt and trypsin during postoperative days 14-56. In conclusion, it took longer for the hypertrophied pancreas to return to the normal size (14 or more d) than for the normal size pancreas to become hypertrophied (7d).
authors: Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
authors: K
authors: K
authors: Miyasaka
authors: K
authors: K
authors: Tateishi
authors: M
authors: M
authors: Matsumoto
authors: A
authors: A
authors: Funakoshi
mesh_terms: D000818:Animals; D001483:Base Sequence; D001646:Bile / Q000737:chemistry / Q000502:physiology*; D001647:Bile Acids and Salts / Q000378:metabolism; D002766:Cholecystokinin / Q000097:blood* / Q000378:metabolism; D006984:Hypertrophy; D007413:Intestinal Mucosa / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008969:Molecular Sequence Data; D009929:Organ Size; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D010189:Pancreatic Juice / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism*
chemical_list: D001647:Bile Acids and Salts; D012333:RNA, Messenger; D013004:Somatostatin; D002766:Cholecystokinin; D014357:Trypsin