MHC-unrestricted immune surveillance of leukemia.
The characteristics of natural killer (NK) cells and their role in immunosurveillance of cancer is reviewed. Evidence derived from in vitro and in vivo experiments is in favor of an important role of NK cells in host resistance to leukemia, as illustrated by studies of untreated patients, patients treated with biological response modifiers and by bone marrow transplantation.
Pawelec
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Second Department of Internal Medicine, University of Tübingen Medical School, Federal Republic of Germany.
D000328:Adult; D000818:Animals; D016026:Bone Marrow Transplantation; D002477:Cells / Q000821:virology; D002648:Child; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology / Q000473:pathology; D007157:Immunologic Surveillance; D016219:Immunotherapy, Adoptive; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology / Q000637:transplantation; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology* / Q000637:transplantation; D007938:Leukemia / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000628:therapy; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008819:Mice, Nude; D016513:Mice, SCID; D016879:Salvage Therapy