Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1.
The human CCND1/PRAD1 gene, located in the 11q13 chromosomal region, encodes a cyclin D protein with potential oncogenic capacity and is involved in several human malignancies. The amplification and expression status of CCND1 was investigated in a series of oesophageal tumours. CCND1 is amplified in 54% and overexpressed in 63% of the tumours of the squamous cell type.
Adélaide
J
J
Laboratoire de Biologie des Tumeurs, Institut Paoli-Calmettes, Marseille, France.
Monges
G
G
Dérdérian
C
C
Seitz
J F
JF
Birnbaum
D
D
D002880:Chromosomes, Human, Pair 11; D016213:Cyclins / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D005784:Gene Amplification; D006801:Humans
D016213:Cyclins