Bacteriostatic and bactericidal activities of paromomycin against Mycobacterium avium complex isolates.
The MICs and MBCs of paromomycin for 32 Mycobacterium avium complex (MAC) strains isolated from patients with the acquired immunodeficiency syndrome were determined by a radiometric broth dilution method. The MICs for the majority of strains were either 8 or 16 mg/L and the MBCs were four- to eight-fold higher. Paromomycin merits further evaluation as oral prophylaxis against disseminated MAC infection.
Piersimoni
C
C
Department of Clinical Microbiology, General Hospital Umberto I., Torrette, Ancona, Italy.
Bornigia
S
S
De Sio
G
G
Scalise
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D010303:Paromomycin / Q000494:pharmacology*
D010303:Paromomycin