Motor neuron disease and exposure to chemicals--aetiological suggestions from a case-control study.
A recent case-control study indicates that some males are genetically predisposed to develop motor neuron disease if they are exposed to chemicals, particularly solvents. Markers for such a predisposition are hereditary for a neurodegenerative disease and/or a thyroid disease. The reason for this susceptibility might be pharmacogenetic polymorphism, which causes deficient detoxification entailing oxidative stress and cell death.
Gunnarsson
L G
LG
Department of Neurology, Orebro Medical Center Hospital, Sweden.
D000368:Aged; D016022:Case-Control Studies; D004560:Electricity; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000139:chemically induced* / Q000453:epidemiology; D016273:Occupational Exposure; D018570:Risk Assessment; D013548:Sweden / Q000453:epidemiology; D014896:Welding
D005819:Genetic Markers