title: An examination of linkage of schizophrenia and schizoaffective disorder to the pseudoautosomal region (Xp22.3)
abstract: We investigated linkage between schizophrenia and the loci DXYS14, DXYS17, and MIC2 within the pseudoautosomal region in 85 families with two or more siblings suffering from schizophrenia or schizoaffective disorder. A maximum lod score of 2.44 was reached at MIC2, with a dominant model of inheritance at a recombination fraction of 0.367 in females and 0.046 in males (a F:M sex ratio > 1, i.e. opposite to that expected with a pseudoautosomal locus). Evidence consistent with linkage (P = 0.01) was also obtained with a sibling pair analysis at the MIC2 locus. These data do not support (although they do not definitively exclude) a locus within the pseudoautosomal region; they are consistent with the presence of a gene that predisposes to schizophrenia in the sex-specific regions of the X and Y chromosomes.
authors: Division of Psychiatry, Northwick Park Hospital, Harrow, Middlesex, UK.
authors: T J
authors: TJ
authors: Crow
authors: L E
authors: LE
authors: Delisi
authors: R
authors: R
authors: Lofthouse
authors: M
authors: M
authors: Poulter
authors: T
authors: T
authors: Lehner
authors: N
authors: N
authors: Bass
authors: T
authors: T
authors: Shah
authors: C
authors: C
authors: Walsh
authors: A
authors: A
authors: Boccio-Smith
authors: G
authors: G
authors: Shields
mesh_terms: D000328:Adult; D000483:Alleles; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D015331:Cohort Studies; D015342:DNA Probes; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011618:Psychotic Disorders / Q000235:genetics* / Q000523:psychology; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D005819:Genetic Markers