Cyclical breast pain and swelling in relation to differing patterns of suppression of ovarian activity with the luteinizing hormone-releasing hormone analogue buserelin acetate: case report.
The presenting complaints of an amenorrhoeic (after hysterectomy with ovarian preservation) woman were cyclical breast pain and swelling. These showed synchronicity with fluctuations in E2 levels. Both ovarian activity and symptoms initially responded to (after lag periods of approximately 40 days) daily SC injections of the LH-RH analogue buserelin acetate. After a break in treatment, the interval between reinitiation of therapy and suppression of E2 levels was prolonged markedly, ovarian function being apparently resistant even to very large doses of the analogue.
Magill
P
P
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Maternity Hospital, Oxford, United Kingdom.
Barlow
D
D
D001941:Breast Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002064:Buserelin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004487:Edema / Q000139:chemically induced* / Q000188:drug therapy; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced* / Q000188:drug therapy
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D002064:Buserelin