Lipid modifications of trimeric G proteins.
G protein alpha subunits and beta gamma dimers are covalently modified by lipids. The emerging picture is one in which attached lipids provide more than just a nonspecific "glue" for sticking G proteins to membranes. We are only beginning to understand how different lipid modifications of different G protein subunits affect specific protein-protein interactions and localization to specific cellular sites. In addition, regulation of these modifications, particularly palmitoylation, can provide new ways to regulate signals transmitted by G proteins.
Wedegaertner
P B
PB
Department of Pharmacology, University of California, San Francisco 94143.
Wilson
P T
PT
Bourne
H R
HR
D000595:Amino Acid Sequence; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D050356:Lipid Metabolism; D008969:Molecular Sequence Data; D019814:Myristic Acid; D009227:Myristic Acids / Q000737:chemistry; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000737:chemistry; D017368:Protein Prenylation
D009227:Myristic Acids; D010169:Palmitic Acids; D019814:Myristic Acid; D019308:Palmitic Acid; D019204:GTP-Binding Proteins