Prospective, randomized, placebo-controlled, double-blind testing of colour vision and electroretinogram at therapeutic and subtherapeutic digitoxin serum levels.
In a prospective, randomized, double-blind study with 10 healthy probands, changes in colour discrimination and in the pattern electroretinogram (P-ERG) and visually evoked cortical potentials (P-VECP) were monitored at therapeutic and subtherapeutic digitoxin serum levels. There was a slight increase in the total error score in the Farnsworth-Munsell 100-hue test at 0.1 mg digitoxin per day in comparison with the placebo. P-ERG and P-VECP did not show any significant changes.
Duncker
G I
GI
Hospital of Ophthalmology, University of Kiel, FRG.
Kisters
G
G
Grille
W
W
D000328:Adult; D003118:Color Perception / Q000187:drug effects / Q000502:physiology*; D003117:Color Vision Defects / Q000139:chemically induced / Q000503:physiopathology*; D004074:Digitoxin / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D004311:Double-Blind Method; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000502:physiology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011863:Radioimmunoassay; D012160:Retina / Q000187:drug effects
D004074:Digitoxin