title: Accuracy of surface fit registration for PET and MR brain images using full and incomplete brain surfaces.
abstract: OBJECTIVE
  The accuracy of a surface-fitting image registration technique has been investigated for matching [18F]fluorodeoxyglucose (FDG) and [15O]H2O PET brain images with MR images. Use of partial-brain surfaces (a single hemisphere or a limited number of slices) was investigated to simulate cases in which severe brain defects or limited axial field of view would preclude using the entire brain surface.
  
  
  METHODS
  Three FDG and three H2O scans were performed on five volunteers, in addition to volume MR studies. Fiducial markers were placed on the subjects' scalps to provide references for registration accuracy. The registration procedure was applied to each PET-MR set, using the surfaces defined by locating the brain edge in multiple slices for each set.
  
  
  RESULTS
  The surfaces fit well, with only 1% scaling necessary for the best fit. Errors in fiducial marker positions between MRI and transformed PET were < 2 mm in the transverse directions and < 4.5 mm in the axial direction. Fits based on the partial surfaces worked well and gave results very similar to the full-brain fits.
  
  
  CONCLUSIONS
  The surface-fitting technique is accurate for FDG and H2O PET studies, even when part of the brain surface cannot be used.
authors: Department of Radiology, Duke University, Durham, North Carolina.
authors: T G
authors: TG
authors: Turkington
authors: J M
authors: JM
authors: Hoffman
authors: R J
authors: RJ
authors: Jaszczak
authors: J R
authors: JR
authors: MacFall
authors: C C
authors: CC
authors: Harris
authors: C D
authors: CD
authors: Kilts
authors: C A
authors: CA
authors: Pelizzari
authors: R E
authors: RE
authors: Coleman
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012535:Scalp; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose