title: Amplification of chromosome subregion 12p11.2-p12.1 in a metastasis of an i(12p)-negative seminoma: relationship to tumor progression?
abstract: Cytogenetic analysis of a metastasis of a human testicular germ cell tumor (seminoma) revealed multiple numerical and structural anomalies, including an abnormally banding region (ABR) present on the short arm of one of the chromosome 12 homologs. Fluorescence in situ- and comparative genomic hybridization experiments revealed that the ABR results from the amplification of 12p11.2-p12.1 derived sequences. We speculate that this particular region may harbor gene(s) relevant for testicular germ cell tumor progression.
authors: Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
authors: R F
authors: RF
authors: Suijkerbuijk
authors: R J
authors: RJ
authors: Sinke
authors: D E
authors: DE
authors: Weghuis
authors: L
authors: L
authors: Roque
authors: A
authors: A
authors: Forus
authors: F
authors: F
authors: Stellink
authors: A
authors: A
authors: Siepman
authors: C
authors: C
authors: van de Kaa
authors: J
authors: J
authors: Soares
authors: A
authors: A
authors: Geurts van Kessel
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D004273:DNA, Neoplasm / Q000032:analysis; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D018239:Seminoma / Q000235:genetics* / Q000556:secondary; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm