Immune intervention in type I diabetes mellitus--current clinical and experimental approaches.
Experiments with animal models have proven that intervention protocols avoiding immunosuppressants can effectively prevent immune-mediated diabetes. These new approaches aim at either supporting the defence of islet cells against inflammatory attack or at modulating the type of the immune response to beta cells towards a more benign quality. Another approach is to reduce the exposure to putative diabetogenic dietary factors during infancy. All of the three strategies are presently tried in clinical studies.
Kolb
H
H
Diabetes-Forschungsinstitut, Universität Düsseldorf/Germany.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D004704:Endocrinology / Q000639:trends*; D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D007515:Islets of Langerhans / Q000187:drug effects / Q000502:physiology; D009536:Niacinamide / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D009536:Niacinamide