title: [CADISO (Cardiovascular Diseases and Stability of the Organism): 10 years of integrated research on natural substances at the Charles University Pharmacy School in Hradec Králové].
abstract: The research project CADISO (Cardiovascular Diseases and Stability of the Organism--Phytotherapeutical Possibilities) is an alliance board associating approximately 20 professional institutions, its centre and coordinating laboratory being the Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Králové. It aims at the prevention (additives in food industry) and therapy of diseases of the circulatory apparatus using phytotherapeutic agents and substances isolated from higher plants and fungi. The project is divided into three systems of investigation: ADAPRETE, i.e. the substances increasing the nonspecific resistance of the organism (adaptogenes of plant origin, immunostimulants), DIACORD, dealing with the substances acting on the cardiovascular system in a mediated way, i.e. treating the diseases the eventual action of which alters the heart and vessels (antihypercholesterolemics, antihyperlipidemics, antidiabetics, anti-oxidants and quenchers of free radicals, hepatoprotectives, anti-aggregating agents), and CORCORAN studying the taxons and substances isolated from them which act directly on the circulatory system (cardiotonic, anti-arrhythmic and vasodilating agents). To achieve a real purpose of the project, the linking-up of the phytochemical, pharmacological-toxicological, pharmaceutical-technological fields, production of raw materials and legislation is ensured.
authors: Katedra farmaceutické botaniky a ekologie Farmaceutické fakulty UK, Hradec Králové.
authors: L
authors: L
authors: Opletal
authors: M
authors: M
authors: Sovová
authors: L
authors: L
authors: Jahodár
authors: J
authors: J
authors: Dusková
authors: P
authors: P
authors: Zácková
authors: J
authors: J
authors: Slavík
authors: R
authors: R
authors: Hrdina
authors: K
authors: K
authors: Kosar
authors: P
authors: P
authors: Solich
authors: M
authors: M
authors: Muzík
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control* / Q000628:therapy; D018153:Czech Republic; D006801:Humans; D010598:Pharmacognosy; D010946:Plants, Medicinal; D012106:Research; D012580:Schools, Pharmacy
vernacular_title: CADISO: 10 let integrovaného výzkumu prírodních látek na Farmaceutické fakultĕ UK v Hradci Králové.