The role of immunoglobulin binding factors in the pathogenesis and therapy of AIDS.
The human immunodeficiency virus (HIV) gp120 and gp41 envelope proteins and Staphylococcus aureus protein A (SPA) all have Fc receptor (FcR)-like immunoglobulin binding factor (IBF) activity for the Fc constant fragments of human immunoglobulin G (IgG). Viral IBF may contribute to the pathology of HIV by jamming the network of FcR signals that control FcR-dependent immunity. Conversely, the bacterial IBF SPA has anti-retroviral activity that may involve antagonism of the immunopathological action of viral IBF, strongly suggesting IBF may act as a double-edged sword that might be turned against viral invaders.
Cowan
F M
FM
Uppsala Inc., Colora, MD 21917.
Madsen
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000628:therapy*; D015483:HIV Antibodies / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015700:HIV Envelope Protein gp41 / Q000276:immunology; D015658:HIV Infections / Q000209:etiology / Q000628:therapy; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D008222:Lymphokines / Q000276:immunology*; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc / Q000276:immunology; D013205:Staphylococcal Protein A / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000276:immunology
D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D013205:Staphylococcal Protein A; D013491:Suppressor Factors, Immunologic; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors