c-erbB-3 protein expression in human breast cancer: comparison with other tumour variables and survival.
c-erbB-3 protein expression was investigated immunohistochemically in a series of 97 malignant breast tumours using the monoclonal antibody RTJ1. Twenty-eight cases (28.8%) showed c-erbB-3 overexpression, 31 cases (32%) showed normal levels of c-erbB-3 and 38 cases (39.2%) were c-erbB-3 negative. c-erbB-3 overexpression was positively but not significantly related to negative lymph node status and survival over a 10-year follow-up period.
Quinn
C M
CM
Department of Histopathology, General Infirmary at Leeds, UK.
Ostrowski
J L
JL
Lane
S A
SA
Loney
D P
DP
Teasdale
J
J
Benson
F A
FA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology*; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D020893:Receptor, ErbB-3; D016019:Survival Analysis
D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors; D020893:Receptor, ErbB-3