The effect of mannitol on reperfusion after severe induced subtotal ischemia of the leg. A hemodynamic, biochemical and metabolic study in a pig hind limb model.
Revascularization of acutely ischemic muscle tissue is followed by edema, decreased oxygen utilization, increased vascular resistance and massive efflux of intracellular compounds indicating loss of cellular integrity, with resultant irreversible damage. In this pig hindlimb study, 8 pigs were submitted to standardized subtotal ischemia of one leg and mannitol was administered i.v. prior to and during 2.5 hours of reperfusion. Compared to 9 controls, the mannitol treated pigs had increased blood flow to the legs, increased oxygen consumption and decreased release of intracellular compounds (CK). This indicates that mannitol attenuates the ischemia/reperfusion syndrome. Muscle energy metabolic parameters showed a similar response to ischemia for both mannitol-treated pigs and controls and no differences in recovery were detected during 2.5 hours of reperfusion between the groups.
Aldman
A
A
Department of Surgery, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Lewis
D H
DH
Elfström
J
J
Mårtensson
J
J
Larsson
J
J
D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D004195:Disease Models, Animal; D004573:Electrolytes / Q000097:blood; D004734:Energy Metabolism / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply*; D007275:Injections, Intravenous; D007511:Ischemia / Q000188:drug therapy / Q000378:metabolism*; D008353:Mannitol / Q000494:pharmacology* / Q000627:therapeutic use; D018482:Muscle, Skeletal / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D015424:Reperfusion; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D013552:Swine
D004573:Electrolytes; D008353:Mannitol; D003402:Creatine Kinase