Antinociceptive action of N-octanoyl GABA--a new GABA mimetic agent.
A new derivative of gamma-aminobutyric acid (GABA) was synthesized. The compound, N-octanoyl GABA (O-GABA), exhibited positive analgesic response in four different models in mice--tail immersion, hot plate, tail clip and acetic acid induced writhing. The antinociceptive activity was significantly blocked by picrotoxin but not by bicuculline or 3-mercaptopropionic acid. Naloxone failed to reverse the antinociceptive response of O-GABA but a synergistic action was observed with pethidine. Pretreatment with atropine significantly reduced the antinociceptive action of O-GABA. Biochemical tests revealed that O-GABA significantly increased brain GABA levels.
Sen
S
S
Department of Pharmaceutical Technology, Jadaypur University, Calcutta, India.
Habibuddin
M
M
Pal
S P
SP
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D018755:GABA Agonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000700:Analgesics; D018755:GABA Agonists; C091500:N-octanoyl-4-aminobutyric acid; D005680:gamma-Aminobutyric Acid