title: A pilot clinical and pharmacological study of intra-arterial infusion of thiotepa.
abstract: Fourteen patients with progressive localized tumors were treated on a clinical and pharmacological study with intra-arterial Thiotepa. A transfemoral percutaneous catheter was inserted into the major artery supplying the tumor. A venous catheter was inserted into the vein draining the tumor area for blood sampling. Doses of Thiotepa ranged from 0.3 mg/kg to 1.0 mg/kg. Courses were repeated monthly and doses of drug escalated as tolerated. Toxicity was mild and doses of drug at least up to 0.9-1.0 mg/kg were tolerable. Pharmacokinetic parameters suggest increasing binding of Thiotepa to tissue when the drug is administered by the intra-arterial route. Clinical responses were observed in a patient with melanoma and in another patient with unknown primary cancer.
authors: Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136.
authors: N
authors: N
authors: Savaraj
authors: L G
authors: LG
authors: Feun
authors: G
authors: G
authors: Blyden
authors: J M
authors: JM
authors: Yrizarry
authors: J T
authors: JT
authors: Hsiang
authors: J
authors: J
authors: Curtas
authors: S
authors: S
authors: Waldman
authors: J D
authors: JD
authors: Post
authors: P
authors: P
authors: Benedetto
authors: H
authors: H
authors: Landy
mesh_terms: D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007261:Infusions, Intra-Arterial; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D010865:Pilot Projects; D013852:Thiotepa / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D013852:Thiotepa