title: Treatment of intractable gastrointestinal manifestations of chronic granulomatous disease with cyclosporine.
abstract: Gastrointestinal manifestations of chronic granulomatous disease of childhood include granulomatous inflammatory bowel disease. Severe colitis and perirectal disease developed in a 12-year-old boy with chronic granulomatous disease while he was receiving interferon gamma therapy. The boy had a deficiency of the 22 kd light chain of the cytochrome b heterodimer. After conventional medical therapy proved to be ineffective, a rapid clinical response was obtained to cyclosporine.
authors: Department of Pediatrics, Mt. Sinai School of Medicine, New York.
authors: J R
authors: JR
authors: Rosh
authors: H B
authors: HB
authors: Tang
authors: L
authors: L
authors: Mayer
authors: G
authors: G
authors: Groisman
authors: S K
authors: SK
authors: Abraham
authors: A
authors: A
authors: Prince
mesh_terms: D001232:Aspergillus fumigatus / Q000302:isolation & purification; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D003573:Cytochrome b Group / Q000172:deficiency; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy*; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D003573:Cytochrome b Group; D007371:Interferon-gamma; D016572:Cyclosporine