Cytokines in alcoholic liver cirrhosis.
Interest for cytokines involvement in experimental and human liver injury has considerably increased over recent years. The present paper reviews the current knowledge in the field of alcoholic cirrhosis. The role of interleukin-1, tumor necrosis factor, interleukin-6, interleukin-8 and interleukin-10 are discussed together with their possible diagnostic and prognostic significance. Prospects for future investigations such as immunotherapy are underlined.
Le Moine
O
O
Department of Gastroenterology and Immunology, ULB, Hôpital Erasme, Bruxelles.
Marchant
A
A
Goldman
M
M
Dupont
E
E
Devière
J
J
D001424:Bacterial Infections / Q000097:blood / Q000150:complications; D015415:Biomarkers; D016207:Cytokines / Q000096:biosynthesis* / Q000494:pharmacology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D015415:Biomarkers; D016207:Cytokines; D007070:Immunoglobulin A; D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10