The role of serum tetranectin, CA 125, and a combined index as tumor markers in women with pelvic tumors.
Serum tetranectin (Se-TN) and CA-125 were measured in 315 patients with a pelvic tumor and 458 healthy females. At a false-positive rate of 0.7% the sensitivity for ovarian cancer stage 1 and 2 was 33% for Se-TN and 76% for both CA 125 and an index based on Se-TN and CA 125 (Index 1). At a false-positive rate of 0.4% the sensitivity was 29% for Se-TN, 62% for CA 125 (35 U/ml), and 76% for Index 1. A negative correlation was found between the Se-TN level and the stage of cancer. The sensitivity for benign tumors was 6% for Se-TN, 17% for CA 125, and 21% for Index 1 at a false-positive rate of 0.4%. In the present study the sensitivity and specificity levels of Se-TN were not sufficiently high to warrant the use of Se-TN as an individual marker for ovarian cancer. The sensitivity rose with the index-based Se-TN and CA 125 without causing a concomitant increase in the rate of false-positive results. None of the markers rose to levels that would allow their use in clinical diagnosis to discriminate between localized cancer and benign tumors.
Høgdall
C K
CK
Department of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark.
Mogensen
O
O
Tabor
A
A
Mogensen
B
B
Jakobsen
A K
AK
Nørgaard-Pedersen
B
B
Larsen
S O
SO
Clemmensen
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D018394:CA-125 Antigen / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D037181:Lectins, C-Type; D016014:Linear Models; D008875:Middle Aged; D009367:Neoplasm Staging; D010386:Pelvic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D018394:CA-125 Antigen; D037181:Lectins, C-Type; C048648:tetranectin