[Synthesis of quinazolino-1,3-benzothiazine derivatives].
The ring-closure reactions of N-(3,4-dimethoxyphenylthio-methyl)-2-nitrobenzamide derivatives 5a,b with phosphoryl chloride gave 4-(2'-nitrophenyl)-2H-1,3-benzothiazine derivatives 7a,b, which on reduction yielded 4-(2'-aminophenyl)-3,4-dihydro-2H-1,3-benzothiazines 8a,b. Reaction of these compounds with phosgene led to the derivatives 9a,b of a new heterocyclic ring system, 6H,8H-quinazolino[3,4-c] [1,3]benzothiazine. The structures of the title compounds were proved by their ir and nmr (1H, 13C) spectra.
Szabó
J
J
Szent-Györgyi Albert Orvostudományi Egyetem, Gyógyszerészi Vegytani Intézet, Szeged.
Bani-Akoto
E
E
Dombi
G
G
Bernáth
G
G
Fodor
L
L
Sohár
P
P
D007202:Indicators and Reagents; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D011799:Quinazolines; D013843:Thiazines
Kinazolino-1,3-benztiazinszármazékok szintézise.