Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats.
In intact, non-ovariectomized female rats in spontaneous behavioral estrus, the i.c.v. injection of oxytocin significantly increased lordosis quotient and lordosis duration, starting from a dose of 1 ng/rat. On the other hand, the oxytocin antagonist, d(CH2)5Tyr(Me)-[Orn]8-vasotocin, injected at the same doses and by the same route, decreased lordosis quotient and lordosis duration, and prevented the effect of oxytocin. These data further support the notion that oxytocin plays a physiological role in female sexual receptivity.
Benelli
A
A
Department of Biomedical Sciences, University of Modena, Italy.
Poggioli
R
R
Luppi
P
P
Ruini
L
L
Bertolini
A
A
Arletti
R
R
D000818:Animals; D005260:Female; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000502:physiology*; D011187:Posture; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D018709:Statistics, Nonparametric
D010121:Oxytocin; C042951:oxytocin,1-(beta-mercapto-(beta, beta-cyclopentamethylene)propionic acid)-Tyr(OMe)(2)-Orn(8)-