title: Gonadal steroids and neuronal plasticity. Studies in the adult rat hypothalamus.
abstract: In this chapter, recent studies on gonadal steroid-induced neural plasticity in the adult rat hypothalamus have been described. Neurons in the VMN and DMN are capable of rapid, reversible structural alterations in response to a changing hormonal environment. Given the importance of the VMN in mediating lordosis in female rats, the present studies suggest that hormonally induced morphological changes in the VMN may be necessary for the manifestation of lordosis. This possibility is supported by the 5,7-DHT studies which indicate that the induction of dendritic spines on VMN neurons may somehow decrease the threshold of E needed to elicit lordosis. Moreover, the sex differences in hormonal requirements for lordosis in 5,7-DHT-treated rats are probably the result of organizational effects of gonadal steroids. Our data support the idea that activational effects can only be superimposed on existing brain circuitry to a certain degree. Finally, the neuronal plasticity seen in the hypothalamus may be an important physiological mechanism by which gonadal steroid feedback mediates reproductive and behavioral function.
authors: Rockefeller University, New York, New York 10021.
authors: M
authors: M
authors: Frankfurt
mesh_terms: D000818:Animals; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D004967:Estrogens / Q000502:physiology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology* / Q000648:ultrastructure; D009473:Neuronal Plasticity; D051381:Rats; D012701:Serotonin / Q000502:physiology; D012726:Sexual Behavior, Animal / Q000502:physiology
chemical_list: D004967:Estrogens; D012739:Gonadal Steroid Hormones; D012701:Serotonin