A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics.
A new peptide antibiotic, cypemycin, with a molecular weight of 2,097 (M+H), was isolated from the culture broth of Streptomyces sp. OH-4156. The antibiotic possesses cytocidal activity against P388 leukemia cells in vitro at a concentration of 1.3 microgram/ml (IC50 values), and the antibiotic showed antimicrobial activities against Micrococcus luteus (MIC, 0.2 microgram/ml).
Komiyama
K
K
Kitasato Institute, Tokyo, Japan.
Otoguro
K
K
Segawa
T
T
Shiomi
K
K
Yang
H
H
Takahashi
Y
Y
Hayashi
M
M
Otani
T
T
Omura
S
S
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001430:Bacteriocins; D005285:Fermentation; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001430:Bacteriocins; D010455:Peptides; C085033:cypemycin