Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.
Epithelia and mesenchyme interact during various physiologic and pathologic processes. Scatter factor is a mesenchyme-derived cytokine that stimulates motility, proliferation, and morphogenesis of epithelia. Recent studies suggest that scatter factor and its receptor (c-met) mediate mesenchyme/epithelia signalling and even interconversion. In this mini-review, we will discuss how scatter factor and c-met may mediate interactions between mesenchyme and epithelia during embryogenesis, organ repair, and neoplasia.
Rosen
E M
EM
Long Island Jewish Medical Center, Long Island Campus for Albert Einstein College of Medicine, Department of Radiation Oncology, New Hyde Park, New York 11042.
Nigam
S K
SK
Goldberg
I D
ID
D000818:Animals; D002450:Cell Communication; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D012038:Regeneration; D015398:Signal Transduction
D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases