Heat shock protein-peptide complexes in cancer immunotherapy.
Heat shock proteins (HSPs) are associated with a broad spectrum of peptides derived from the cells from which they are isolated. Vaccination with such HSP-peptide complexes elicits protective immunity against tumors or other cells used as the source of HSPs. These observations suggest that HSP-peptide complexes are suitable as vaccines against cancers and infectious diseases.
Srivastava
P K
PK
Department of Biological Sciences, Fordham University, Bronx, New York 10458.
Udono
H
H
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D014612:Vaccines / Q000276:immunology
D000951:Antigens, Neoplasm; D006360:Heat-Shock Proteins; D014612:Vaccines