title: A novel glycoprotein in the olfactory and pituitary systems of larval and adult lampreys.
abstract: A novel homodimeric glycoprotein was isolated and characterized from the pituitaries of adult sea lampreys, Petromyzon marinus, modern representatives of the earliest vertebrates. The monomer consists of 121 amino-acid residues in a sequence that has no resemblance to any known pituitary hormone. Whereas this protein is localized in most cells of the rostral pars distalis of adult lampreys, we have chosen to name it, nasohypophysial factor (NHF), because it first appears in the olfactory system of developing larval lampreys. Not only may NHF be a new pituitary hormone but a useful probe for examining the ontogenetic and phylogenetic relationships of the pituitary and olfactory systems in vertebrates.
authors: Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham 03824.
authors: S A
authors: SA
authors: Sower
authors: A
authors: A
authors: Takahashi
authors: M
authors: M
authors: Nozaki
authors: A
authors: A
authors: Gorbman
authors: J H
authors: JH
authors: Youson
authors: J
authors: J
authors: Joss
authors: H
authors: H
authors: Kawauchi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006023:Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007150:Immunohistochemistry; D007798:Lampreys / Q000254:growth & development / Q000378:metabolism*; D007814:Larva; D008969:Molecular Sequence Data; D009833:Olfactory Pathways / Q000378:metabolism*; D010449:Peptide Mapping; D010902:Pituitary Gland / Q000378:metabolism*; D010907:Pituitary Hormones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011863:Radioimmunoassay
chemical_list: D006023:Glycoproteins; D010907:Pituitary Hormones; C091586:nasohypophysial factor