Longitudinal growth and final height in long-term survivors of childhood leukaemia.
Survival of children with acute lymphoblastic leukaemia (ALL) has increased considerably in recent years and data on the spontaneous growth and final height of these children are conflicting. Therefore, we analysed the longitudinal growth and final height in 52 survivors (33 females, 19 males) of childhood ALL. These children were diagnosed and treated in a single institution, all remained in first remission and were submitted to cranial irradiation with either 2400 or 1800 cGy. None of the patients received testicular or spinal irradiation. Median age at diagnosis was 4.2 (range 1.3-9.6) years in the first group (2400 cGy) and 3.9 (0.8-10.5) years in the second (1800 cGy). Standing height was measured at diagnosis, at the end of treatment (median 3.1 years after diagnosis), 6, 12, 24 months after the end of treatment, and finally at the completion of growth. In girls a significant decrease of mean height standard deviation score (SDS) during treatment and a catch up in growth after the end of therapy was followed by a second period of reduced growth. Mean final height SDS was significantly lower than the value at diagnosis in both groups of girls, but only in males treated with 2400 cGy. Mean overall loss in height SDS from diagnosis to final height was higher in females (-1.24) than in males (-0.40) (P = 0.009). Females < or = 4 years of age at diagnosis showed a higher loss in final height than females > 4 years.(ABSTRACT TRUNCATED AT 250 WORDS)
Cicognani
A
A
Clinica Pediatrica I, Bologna, Italy.
Cacciari
E
E
Rosito
P
P
Mancini
A F
AF
Carlă
G
G
Mandini
M
M
Paolucci
G
G
D017668:Age of Onset; D001827:Body Height / Q000187:drug effects / Q000528:radiation effects*; D002648:Child; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D013006:Growth Hormone / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007223:Infant; D007558:Italy; D008137:Longitudinal Studies; D008297:Male; D008572:Menarche / Q000187:drug effects / Q000528:radiation effects; D015999:Multivariate Analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012737:Sex Factors; D017741:Survivors
D013006:Growth Hormone