Woringer-Kolopp disease. A lymphomatoid hypersensitivity reaction.
We report two cases of unilesional pagetoid reticulosis (Woringer-Kolopp disease). Histopathological, immunohistological, ultrastructural, and genotypic studies showed both lesions to be lymphomatoid hypersensitivity reactions, as characterized by polyclonal proliferations of T-lymphocytes; CD8+ T cytotoxic-suppressor (Tc/s) lymphocytes were predominant in one case, whereas CD4+ T helper (Th) lymphocytes were predominant in the other. The nosology of Woringer-Kolopp disease is discussed.
Crowson
A N
AN
Central Medical Laboratories, Misericordia General Hospital, Winnipeg, Canada.
Magro
C M
CM
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D003094:Collagen; D003593:Cytoplasm / Q000648:ultrastructure; D004817:Epidermis / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D006967:Hypersensitivity / Q000473:pathology*; D007223:Infant; D007801:Langerhans Cells / Q000473:pathology; D008206:Lymphatic Diseases / Q000473:pathology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012878:Skin Neoplasms / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*; D013602:T-Lymphocytes, Cytotoxic / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology
D011948:Receptors, Antigen, T-Cell; D003094:Collagen