The role of 5-HT1A serotonin and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats.
The effects of buspirone (5 and 10 mg/kg i.p.), 8-OH-DPAT (0.25 mg/kg) and raclopride (2.5 mg/kg) on the EEG power spectra of the sensorimotor cortex were studied in freely moving rats. Buspirone (5 mg/kg) and 8-OH-DPAT produced selective slowing of the theta-activity. Buspirone (10 mg/kg) produced slowing of the theta-activity and increased the power of the alpha-band (9-11 Hz). Raclopride alone did not influence EEG power spectra. Simultaneous injection of 8-OH-DPAT and raclopride produced marked slowing of the theta-activity and increased the power of the alpha-band. The role of 5 HT1A and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats was discussed.
Bogdanov
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Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences, Moscow, Russia.
Bogdanov
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MB
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D004357:Drug Synergism; D004569:Electroencephalography / Q000187:drug effects*; D008297:Male; D020891:Raclopride; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D044263:Receptors, Serotonin, 5-HT1; D012457:Salicylamides / Q000494:pharmacology; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000502:physiology
D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012457:Salicylamides; D020891:Raclopride; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D002065:Buspirone