Effect of selected dietary antioxidants on fatty liver-haemorrhagic syndrome in laying hens.
1. Single comb White Leghorn hens of an inbred line highly susceptible to fatty liver haemorrhagic syndrome (FLHS) were fed supplemented dietary ascorbic acid (200 mg/kg), alpha-tocopherol (75 mg/kg), or L-cysteine (3 g/kg, and 6 g/kg) for 28 d in order to evaluate the potential therapeutic effect of these compounds against the disease. 2. Supplementation of ascorbic acid, alpha-tocopherol, or a low level of L-cysteine (3 g/kg) did not significantly affect any of the hepatic variables evaluated. Hepatic glutathione was not increased by the supplementation of dietary L-cysteine. 3. L-cysteine supplemented at a level of 6 g/kg decreased hepatic dry matter and fat contents without affecting the hepatic malondialdehyde or the liver haemorrhagic score. 4. Because one of the predisposing factors of FLHS is a high hepatic fat content it was concluded that dietary supplementation of L-cysteine (6 g/kg) may be useful in the prevention of the disease.
Diaz
G J
GJ
Department of Pathology, University of Guelph, Ontario, Canada.
Squires
E J
EJ
Julian
R J
RJ
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology; D002645:Chickens; D003545:Cysteine / Q000008:administration & dosage / Q000494:pharmacology*; D005234:Fatty Liver / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D005527:Food, Fortified; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D006470:Hemorrhage / Q000517:prevention & control / Q000662:veterinary*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010058:Oviposition; D011201:Poultry Diseases; D013577:Syndrome; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D005978:Glutathione; D003545:Cysteine; D001205:Ascorbic Acid