Elimination and metabolism of triiodothyronine depend on the thyroid status in the brain of young chickens.
The hypothyroid chicken brain has been found to preserve more triiodothyronine (T3) than expected from plasma T3 levels. A possible explanation is that the elimination of T3 from the hypothyroid brain is decreased. In the present experiments, the elimination rate of T3 was compared in surgically thyroidectomized animals and sham-operated controls. It was found that both T3 coming from the plasma and T3 derived locally in the cells from thyroxine have a significantly lower elimination rate in thyroidectomized chickens than in sham-operated ones. Therefore it is concluded that the adaptation of the brain to hypothyroid conditions is partly regulated by reducing the loss of the active thyroid hormone (i.e. T3) via metabolic and tissue-to-plasma exchange.
Rudas
P
P
Department of Physiology and Biochemistry, University of Veterinary Science, Budapest, Hungary.
Bartha
T
T
Frenyó
V L
VL
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002645:Chickens / Q000097:blood / Q000378:metabolism*; D007037:Hypothyroidism / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D011201:Poultry Diseases / Q000097:blood / Q000378:metabolism*; D011897:Random Allocation; D013965:Thyroidectomy / Q000662:veterinary; D014284:Triiodothyronine / Q000097:blood / Q000378:metabolism*
D014284:Triiodothyronine