title: Propagation of interictal epileptic activity in temporal lobe epilepsy.
abstract: We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal electrodes in four patients with temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, and functional relationship of the neuronal sources underlying the epileptic spike complexes. In all patients, we found two significant sources generating the interictal spikes which showed considerable overlap in both space and time. Source 1 was located in the mesiobasal temporal lobe and generated a restricted negativity at the ipsilateral sphenoidal electrode and a widespread positivity over the vertex. Source 2 could be attributed to the lateral temporal neocortex and was associated with a relatively restricted negativity at the ipsilateral temporal electrodes and a more widespread positivity over the contralateral hemisphere. The sources were well separated in space, with an average distance of 45 mm between them. The time activities of both sources showed similar biphasic patterns, with the mesial source leading the lateral source by approximately 40 msec, suggesting propagation of interictal epileptic activity from the mesiobasal to the lateral temporal lobe.
authors: Neurological University Clinic, Vienna, Austria.
authors: C
authors: C
authors: Baumgartner
authors: G
authors: G
authors: Lindinger
authors: A
authors: A
authors: Ebner
authors: S
authors: S
authors: Aull
authors: W
authors: W
authors: Serles
authors: A
authors: A
authors: Olbrich
authors: S
authors: S
authors: Lurger
authors: T
authors: T
authors: Czech
authors: R
authors: R
authors: Burgess
authors: H
authors: H
authors: Lüders
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology*