Molecular aspects concerning antigen oligopeptide selection by MHC class I molecules.
T cells can recognize the antigen only if it is associated with self MHC molecules on the surface of antigen presenting cells (APC). There are several characteristic parameters defining interaction of MHC molecule with antigenic peptides giving circumstances for specific antigen presentation and an individualized immune response. Here are assessed some size and conformational parameters of the peptides presented by MHC class I molecules-lengths, widths, van der Waals volumes and surfaces-using COSMIC 2.0 software. The peptides derived from HIV gp 160 are obtained from literature and are known to be active and inactive in a cytotoxicity assay. An increased tendency for beta- or beta-like structures and volumes close to those of the MHC binding site are encountered in the case of active peptides.
Drugărin
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D
Department of Physiology, University of Medicine and Pharmacy, Timişoara, Romania.
Simon
Z
Z
Sulea
T
T
Tatu
C A
CA
D000595:Amino Acid Sequence; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000235:genetics / Q000276:immunology*; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology; D015686:Gene Products, env / Q000235:genetics / Q000276:immunology; D005805:Genes, MHC Class I / Q000235:genetics / Q000276:immunology*; D015488:HIV Antigens / Q000235:genetics / Q000276:immunology; D019302:HIV Envelope Protein gp160; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000235:genetics / Q000276:immunology*; D011498:Protein Precursors / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D000954:Antigens, Surface; D015686:Gene Products, env; D015488:HIV Antigens; D019302:HIV Envelope Protein gp160; D008024:Ligands; D009842:Oligopeptides; D011498:Protein Precursors