Reduction of GABAA and GABAB receptor densities in the cerebellar cortex from 3-acetylpyridine-induced ataxic rats.
We measured GABAA and GABAB receptor densities in the cerebellar cortex from 3-acetylpyridine-induced ataxic rats using receptor autoradiography. GABAA and GABAB receptor densities were significantly reduced both in the molecular layer and the granule cell layer. Reduction of GABA receptor densities may be induced by loss of GABA receptors on the degenerated climbing fibers or by secondary or compensatory changes of neuronal activities in the cerebellum.
Kannari
K
K
Third Department of Medicine, Hirosaki University School of Medicine, Japan.
Tomiyama
M
M
Matsunaga
M
M
D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D001345:Autoradiography; D002525:Cerebellar Cortex / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D018080:Receptors, GABA-B / Q000378:metabolism*
D011725:Pyridines; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; C010835:3-acetylpyridine