Elimination studies of antipyrine and its metabolites in healthy Saudi Arabians.
1. We measured the antipyrine clearance in 18 healthy Saudi subjects and determined the urinary excretion of three of its metabolites: 4-hydroxyantipyrine (4-OH AP), norantipyrine (NOR AP) and 3 hydroxymethylantipyrine (3-OHM AP) in 21 subjects. 2. The mean +/- SD of the antipyrine clearance was 2.4 +/- 1.1 h-1 (range 1.0-5.5 l h-1) and the corresponding value per kg body weight was 0.6 +/- 0.2 ml min-1 kg-1. Urinary excretion of antipyrine (AP), 4-OH AP, NOR AP and 3-OHM AP expressed as a percentage of the oral dose of antipyrine given was 2.8 +/- 2.2, 14.5 +/- 6.9, 12.3 +/- 5.6 and 7.6 +/- 3.2 respectively. 3. Compared to Africans, Saudis preferentially metabolize AP to NOR AP and compared to Caucasians to 3-OHM AP, rather than to 4-OH AP. These discrepancies may reflect age differences between the study populations rather than genetic or ethnic variations.
Ali
H A
HA
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
el-Yazigi
A
A
Sieck
J O
JO
Døssing
M
M
Saour
J
J
Raines
D A
DA
Ernst
P
P
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000652:urine; D044466:Asian People; D044383:Black People; D002851:Chromatography, High Pressure Liquid; D000077553:Edaravone; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D012529:Saudi Arabia; D044465:White People
C007983:4-hydroxyantipyrine; C031820:3-hydroxymethylantipyrine; D000077553:Edaravone; D000983:Antipyrine