Immunorestorative effect of glucan immunomodulator on guinea pigs with experimental ascariosis.
The immunorestorative effect of glucan immunomodulator, combined with porcine immunoglobulin and zinc (GI) on T- and B-lymphocytes and peritoneal macrophage phagocytic ability was studied in guinea pigs with experimental ascariosis (Ascaris suum) after a cyclophosphamide (CY)-evoked immunosuppression. During the migration phase of A. suum infection GI exerted a significant restorative effect on the CY-reduced percentage occurrence of T- and B-cell populations in the mesenteric, mediastinal and hepatic lymph nodes and spleen of A. suum hosts. On the contrary, it did not influence the CY-suppressed phagocytic activity and index of phagocytic activity of the peritoneal macrophages. The protective effect of the GI evaluated by the reduction in the number of migrating ascarid larvae in the lungs of guinea pigs after immunosuppression with CY and administration of GI was 14.46% higher, compared with the suppressed and infected group without administration of GI.
Soltýs
J
J
Parasitological Institute SAS, Kosice, Slovak Republic.
Benková
M
M
Borosková
Z
Z
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001196:Ascariasis / Q000276:immunology / Q000662:veterinary*; D017165:Ascaris suum / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D005936:Glucans / Q000494:pharmacology*; D006168:Guinea Pigs / Q000276:immunology* / Q000469:parasitology; D007136:Immunoglobulins / Q000494:pharmacology; D008168:Lung / Q000469:parasitology; D008221:Lymphoid Tissue / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects; D008297:Male; D008954:Models, Biological; D010587:Phagocytosis / Q000276:immunology; D012376:Rodent Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D015032:Zinc / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D005936:Glucans; D007136:Immunoglobulins; D003520:Cyclophosphamide; D015032:Zinc