Excretion of 3-hydroxy-diflunisal as a monosulphate conjugate--identification using ESI-MS.
Electrospray-ionization mass spectrometry was used to identify a novel, highly polar metabolite of diflunisal isolated from Gunn rat urine. Negative ion spectra were obtained of the sulphate conjugate of diflunisal and the new metabolite, which was identified as a sulphate conjugate of 3-hydroxydiflunisal.
Dickinson
R G
RG
Department of Medicine, University of Queensland, Royal Brisbane Hospital, Australia.
King
A R
AR
Kelly
M A
MA
Kaltashov
I A
IA
Fenselau
C
C
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004061:Diflunisal / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism* / Q000652:urine; D013058:Mass Spectrometry / Q000379:methods; D051381:Rats; D011911:Rats, Gunn; D013431:Sulfates / Q000378:metabolism
D013431:Sulfates; C091289:3-hydroxydiflunisal; D004061:Diflunisal