title: Acquired idiopathic pure red cell aplasia in a hemodialyzed patient with inactive systemic lupus erythematosus.
abstract: A male patient suffered chronic renal failure due to lupus nephritis and was undergoing hemodialysis. Six years after beginning hemodialysis, anemia developed, which improved by erythropoietin. Unresponsiveness to erythropoietin gradually appeared, and with a suspicion of pure red cell aplasia, he was treated with a high-dose corticosteroid but the unresponsiveness did not improve. Neither his serum nor lymphocytes inhibited erythropoiesis of either normal bone marrow stem cells or his own in vitro. These observations suggest an impaired hematopoietic microenvironment in his bone marrow.
authors: Department of Internal Medicine, Keio University School of Medicine, Tokyo.
authors: H
authors: H
authors: Okada
authors: H
authors: H
authors: Suzuki
authors: H
authors: H
authors: Uchida
authors: Y
authors: Y
authors: Kanno
authors: Y
authors: Y
authors: Kitamura
authors: T
authors: T
authors: Hisamatsu
authors: N
authors: N
authors: Deguchi
authors: D
authors: D
authors: Hayashi
authors: T
authors: T
authors: Saruta
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002908:Chronic Disease; D003114:Colony-Forming Units Assay; D004359:Drug Therapy, Combination; D004920:Erythropoiesis; D004921:Erythropoietin / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008181:Lupus Nephritis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006435:Renal Dialysis
chemical_list: D000305:Adrenal Cortex Hormones; D004921:Erythropoietin