Experimental beta beta'-iminodipropionitrile (IDPN) neuropathy: neurofilament profile of sensory, motor and autonomic nerves as seen by immunocytochemistry on whole-mount preparations.
IDPN-induced changes in a variety of sensory, motor and autonomic nerves were studied by whole-mount immunocytochemistry. A full range of proximo-distal accumulations of neurofilament-like material was found, from paranuclear round bodies in perikarya to distal and preterminal axonal dilations. Conversely, both terminal areas and nodal-paranodal regions of myelinated axons showed striking, sharply localized loss of neurofilament-immunostaining. The latter change, when transport of neurofilaments is halted by IDPN, may indicate their local processing and/or differential transport at nodal-paranodal regions.
Ferri
G L
GL
Department of Cytomorphology, University of Cagliari, Italy.
Cichi
A
A
Bastone
A
A
Gaudio
R M
RM
Frontali
N
N
Dahl
D
D
D000818:Animals; D001341:Autonomic Nervous System / Q000737:chemistry*; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000737:chemistry*; D008297:Male; D009046:Motor Neurons / Q000737:chemistry*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000378:metabolism*; D009475:Neurons, Afferent / Q000737:chemistry*; D009498:Neurotoxins; D009570:Nitriles; D051381:Rats; D017207:Rats, Sprague-Dawley
D009498:Neurotoxins; D009570:Nitriles; C008110:3,3'-iminodipropionitrile