title: Synthesis of some 4-thiazoline and 4H-1,2,4-triazole derivatives of imidazo[1,2-a]pyridine as possible anticonvulsants.
abstract: Several 2-[(2-methylimidazo[1,2-a]pyridine-3-yl)carbonyl]hydrazono- 3-nonsubstituted/substituted-4-phenyl-4-thiazolines (3a-d, 3f-h) and 3-(2-methylimidazo[1,2-a]pyridine-3-yl)-4-nonsubstituted/substitut ed-5- mercapto-4H-1,2,4-triazoles (4a-f, 4i) were synthesized, characterized and evaluated for anticonvulsant activity. Only 3g showed significant activity against MES induced seizures.
authors: Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Istanbul, Turkey.
authors: N
authors: N
authors: Cesur
authors: Z
authors: Z
authors: Cesur
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D011725:Pyridines; D013844:Thiazoles; D014230:Triazoles