title: [Clinico-experimental study of using plant preparations from the flowers of Filipendula ulmaria (L.) Maxim for the treatment of precancerous changes and prevention of uterine cervical cancer].
abstract: The paper reports the results of the experimental and clinical evaluation of the administration of drugs prepared from flowers of Filipendula ulmaria (L.) Maxim for cervical dysplasia and cancer treatment. Local administration of decoction resulted in a 39% drop in the frequency of squamous-cell carcinoma of the cervix and vagina induced in mice by 7,12-dimethyl-benz(a)anthracene treatment. Positive response was recorded in 32 patients (67%), including 25 cases (52%) of complete regression of dysplasia, out of 48 cases of cervical dysplasia treated with courses of ointment application. No recurrence was observed in 10 completely cured patients within 12 months.
authors: A P
authors: AP
authors: Peresun'ko
authors: V G
authors: VG
authors: Bespalov
authors: A I
authors: AI
authors: Limarenko
authors: V A
authors: VA
authors: Aleksandrov
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D001551:Benz(a)Anthracenes; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006801:Humans; D051379:Mice; D008812:Mice, Hairless; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D010946:Plants, Medicinal; D002578:Uterine Cervical Dysplasia / Q000188:drug therapy*; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D014625:Vaginal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D001551:Benz(a)Anthracenes; D010936:Plant Extracts
vernacular_title: Kliniko-éksperimental'noe izuchenie vozmozhnosteĭ primeneniia fitopreparatov iz tsvetkov labaznika viazolistnogo dlia lecheniia predrakovykh izmeneniĭ i profilaktiki raka sheĭki matki.