title: Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR.
abstract: A rearrangement between the PML and RAR-alpha genes underlies the acute promyelocytic leukemia (APL)-specific t(15;17) translocation, leading to the production of a chimeric mRNA. Recent development of a reverse-transcription polymerase chain reaction (RT-PCR) assay for the PML/RAR-alpha hybrid has proven useful for rapid diagnosis and monitoring of minimal residual disease (MRD) in APL patients. Preliminary studies in which the prognostic significance of RT-PCR was evaluated indicate that this test may identify patients at high risk of relapse.
authors: Department of Human Biopathology, University La Sapienza, Rome, Italy.
authors: D
authors: D
authors: Diverio
authors: P P
authors: PP
authors: Pandolfi
authors: V
authors: V
authors: Rossi
authors: A
authors: A
authors: Biondi
authors: P G
authors: PG
authors: Pelicci
authors: F
authors: F
authors: Lo Coco
mesh_terms: D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000503:physiopathology; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis*; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: D012333:RNA, Messenger