title: Determinants of left ventricular function two weeks and one year after an acute myocardial infarction.
abstract: This study examines possible covariates of left ventricular function two weeks and sixteen months after an acute infarction. It was performed in a group of 312 patients randomized double blindly to recombinant tissue plasminogen activator (rt-PA) (n = 156) or placebo treatment and followed thereafter for at least one year. Two weeks after the infarction, enzymatic infarct size, infarct-related vessel, and number of diseased coronary arteries were significant determinants of the infarct-related regional wall motion (centerline method) (R2 = 0.25 to 0.60, P = 0.0001). Enzymatic infarct size, regional wall motion of both infarct-related and remote areas, reinfarction, and treatment allocation were significant independent correlates of ejection fraction (R2 = 0.76), end-diastolic volume (R2 = 0.20), and end-systolic volume (R2 = 0.69, P < 0.0001). Infarct-related coronary artery and predischarge end-systolic volume were significant independent covariates of ejection fraction at rest (R2 = 0.47) after sixteen months. Age, enzymatic infarct size, and predischarge end-diastolic volume were independent determinants of the maximal (R2 = 0.49, P < 0.0001) and peak exercise ejection fraction (R2 = 0.49, P < 0.0001).
authors: Department of Cardiology, K. U. Leuven, Belgium.
authors: T
authors: T
authors: Brzostek
authors: F
authors: F
authors: Van de Werf
authors: I
authors: I
authors: Scheys
authors: L
authors: L
authors: Mortelmans
authors: A
authors: A
authors: Aubert
authors: J S
authors: JS
authors: Dubiel
authors: H
authors: H
authors: De Geest
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D012044:Regression Analysis; D012189:Retrospective Studies; D013318:Stroke Volume; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000494:pharmacology / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator