title: Vascular mineralization in the monkey brain.
abstract: Mineralization of various degrees was found in the brains of 79 (59%) of 134 cynomolgus monkeys (Macaca fascicularis). There was no age dependency in the incidence or severity, nor were there any abnormalities in growth, weight gain, or neurologic signs, although a slight sex difference was observed. The lesions, which were basophilic and intensely positive for periodic acid-Schiff or von Kossa stain, occurred in the vascular walls of the globus pallidus in two types: globoid bodies with prominent concentric lamellar structures in and around the arteriolar and venular wall (type A) and fine granules in the media of small or medium-sized arteries (type B). Electron microscopic examination revealed dense deposits in the degenerated media of small or medium-sized arteries or the thickened walls of the arterioles. X-ray microanalysis demonstrated the presence of calcium, phosphorus, iron, zinc, magnesium, and aluminum.
authors: Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.
authors: T
authors: T
authors: Yanai
authors: T
authors: T
authors: Masegi
authors: K
authors: K
authors: Ueda
authors: J
authors: J
authors: Manabe
authors: M
authors: M
authors: Teranishi
authors: M
authors: M
authors: Takaoka
authors: N
authors: N
authors: Matsunuma
authors: K
authors: K
authors: Fukuda
authors: N
authors: N
authors: Goto
authors: K
authors: K
authors: Fujiwara
mesh_terms: D000818:Animals; D002114:Calcinosis / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005917:Globus Pallidus / Q000098:blood supply* / Q000473:pathology*; D008252:Macaca fascicularis; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D008992:Monkey Diseases / Q000473:pathology*