Structure and chromosomal mapping of genes for the mouse kappa-opioid receptor and an opioid receptor homologue (MOR-C).
Recent cDNA cloning studies have defined four members of the opioid receptor family, i.e., delta-, mu- and kappa-subtypes, and an opioid receptor homologue for unknown ligands. In this report, we isolated and analyzed mouse genomic DNA segments containing the kappa-opioid receptor gene and a gene for the opioid receptor homologue (designated as MOR-C). The genes are closely related each other in exon-intron organization, suggesting their evolutional relationship. Using in situ hybridization, we show that the kappa-opioid receptor gene and the MOR-C gene map to mouse chromosome 1A2-3 and 2H2-4, respectively.
Nishi
M
M
Department of Neurochemistry, Tokyo Institute of Psychiatry, Japan.
Takeshima
H
H
Mori
M
M
Nakagawara
K
K
Takeuchi
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry; D005091:Exons; D015698:Genomic Library; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D011957:Receptors, Opioid / Q000235:genetics*; D017473:Receptors, Opioid, kappa / Q000235:genetics*; D015183:Restriction Mapping; D017385:Sequence Homology; D000094942:Nociceptin Receptor
D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D004247:DNA; D000094942:Nociceptin Receptor; C000722287:Oprl1 protein, mouse