The 5-amino-3-methyl-4-ureidoisoxazoles, synthesis and antileucemic activity.
Some new substituted 5-amino-3-methyl-4-ureidoisoxazoles and the 4-ethyl urethane of the 5-amino-3-methyl-isoxazole have been synthesized from 5-amino-3-methyl-4-isoxazolecarboxylic acid azide. Some representative ureides with primary, secondary, and heterocyclic amines were tested for their antileucemic activity.
Ryng
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Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
Duś
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D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007624:KB Cells; D007938:Leukemia / Q000188:drug therapy*; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007555:Isoxazoles