title: Preparation and characterization of ethylcellulose microspheres containing 5-fluorouracil.
abstract: Ethylcellulose microspheres containing 5-fluorouracil (5-FU) were prepared by a solvent evaporation technique using light mineral oil as the continuous phase. The drug was suspended in the acetone solution of the polymer. Three drug/polymer ratios (1/1, 1/2 and 1/3) were utilized. The microspheres were studied with respect to size, drug content and surface characteristics; the higher the polymer content, the smoother the microspheres. The drug was suspended in the polymer and the drug loading was important (more than 90%) with the three types of microspheres. In vitro dissolution studies in phosphate buffer showed that the 5-FU release was dependent on the drug/polymer ratio for the 400-500 microns granulometric fraction.
authors: Faculté des Sciences Pharmaceutiques et Biologiques, Université de Nancy I, France.
authors: C
authors: C
authors: Zinutti
authors: F
authors: F
authors: Kedzierewicz
authors: M
authors: M
authors: Hoffman
authors: P
authors: P
authors: Maincent
mesh_terms: D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004355:Drug Stability; D005472:Fluorouracil / Q000008:administration & dosage* / Q000737:chemistry*; D008863:Microspheres; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; C013517:ethyl cellulose; D002482:Cellulose; D005472:Fluorouracil