Circulating fluoride changes and hepatorenal function following sevoflurane anaesthesia.
Sevoflurane, a new volatile inhalational agent, undergoes biotransformation to fluoride which is potentially nephrotoxic. We compared the effects of sevoflurane or isoflurane anaesthesia on hepatorenal function and serum fluoride concentrations in 50 ASA 1-3 patients undergoing major intra-abdominal surgery. No patient developed renal or hepatic dysfunction. Mean (SEM) peak fluoride concentrations were 23.1 (1.5) mumol.l-1 for sevoflurane and 5.4 (0.4) mumol.l-1 for isoflurane (p < 0.001). There was a significant correlation in the sevoflurane group between the total dose of agent (MAC h), the total fluoride production (r = 0.78, p = 0.0001) and peak fluoride concentration (r = 0.57, p = 0.003). There was no correlation between these variables in the isoflurane group.
Newman
P J
PJ
Department of Anaesthesia, St George's Hospital Medical School, London.
Quinn
A C
AC
Hall
G M
GM
Grounds
R M
RM
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000768:Anesthesia, General; D000777:Anesthetics; D001663:Bilirubin / Q000097:blood; D004987:Ethers; D005260:Female; D005459:Fluorides / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007530:Isoflurane; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008738:Methyl Ethers; D000077149:Sevoflurane
D000777:Anesthetics; D004987:Ethers; D006454:Hemoglobins; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005459:Fluorides; D001663:Bilirubin