title: Efficiency of three different hemodialysis membranes for plasma porphyrin removal.
abstract: To assess the capability of three different membranes to remove porphyrins, plasma and dialysate porphyrin levels were fluorometrically measured in 10 patients with end-stage renal failure who were on hemodialysis. Three different hemodialysis membranes were used: cuprophan, polyacrylonitrile, and cellulose triacetate. Total plasma porphyrin concentrations decreased after dialysis, but to a lesser extent when using the cuprophan membrane (19%) than with the polyacrylonitrile (26%) or cellulose triacetate (30%) membranes (P < 0.01). However, since the free plasma porphyrin fraction remained unchanged, it can be assumed that the equilibrium between protein-bound and non-protein-bound (free) porphyrins is displaced toward the latter fraction. Dialysate porphyrin levels were lower (P < 0.01) when using the cuprophan membrane (10.1 micrograms/session) than when using polyacrylonitrile (17.8 micrograms/session) and cellulose triacetate (21.9 micrograms/session). Although most of the plasma porphyrins are protein bound, our results show that hemodialysis can remove significant amounts of non-protein-bound (free) porphyrins. The polyacrylonitrile and cellulose triacetate membranes had a greater capacity for porphyrin removal than cuprophan. Thus, two high-permeability membranes (polyacrylonitrile and cellulose triacetate) should be used whenever a reduction of plasma porphyrin levels is desired.
authors: Porphyria Unit, Hospital Universitario Doce de Octubre, Madrid, Spain.
authors: A
authors: A
authors: Fontanellas
authors: J A
authors: JA
authors: Herrero
authors: M J
authors: MJ
authors: Moran
authors: F
authors: F
authors: Coronel
authors: P
authors: P
authors: Sepulveda
authors: A
authors: A
authors: Barrientos
authors: R
authors: R
authors: Enriquez De Salamanca
mesh_terms: D000180:Acrylic Resins; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011166:Porphyrins / Q000097:blood*; D006435:Renal Dialysis / Q000295:instrumentation*
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011166:Porphyrins; C010504:polyacrylonitrile; D002482:Cellulose; C024671:cellulose triacetate; C009865:cuprammonium cellulose