[The plasticity of the snail cholinoreceptor neurons following exposures to the inositol 1,4,5-triphosphate- and Ca2(+)-dependent mobilization of deposited Ca2(+) and the level of phosphatidic acid].
Effects of some substances (which influence on mobilization of deported Ca2+ and intracellular level of second messengers) on identified neurons RPa3 and LPa3 of Helix lucorum were studied using two-electrode voltage clamp technique. The action of inositol-1,4,5-trisphosphate (IP3), inositolhexakisphosphate (IP6), TMB-8 inhibitor of IP3-dependent Ca2+ mobilization), tetracaine (inhibitor of Ca(2+)-dependent mobilization of Ca2+), and phospholipase D (which catalyzes phosphatidic acid formation from membrane phosphatidylcholine) was studied. Participation of IP3, IP3-dependent-, Ca(2+)-dependent mobilized intracellular Ca2+ and phosphatidic acid in regulation of cholinoreceptor plasticity was shown in Helix neurons.
Pivovarov
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D000818:Animals; D002118:Calcium / Q000494:pharmacology* / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D017952:Ganglia, Invertebrate / Q000187:drug effects / Q000378:metabolism; D006372:Helix, Snails / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D015544:Inositol 1,4,5-Trisphosphate / Q000494:pharmacology* / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D010712:Phosphatidic Acids / Q000378:metabolism*; D010739:Phospholipase D / Q000494:pharmacology; D010833:Phytic Acid / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000378:metabolism; D015290:Second Messenger Systems / Q000187:drug effects / Q000502:physiology; D013748:Tetracaine / Q000494:pharmacology
D002121:Calcium Channel Blockers; D010712:Phosphatidic Acids; D011950:Receptors, Cholinergic; D013748:Tetracaine; C006014:8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate; D005707:Gallic Acid; D010833:Phytic Acid; D015544:Inositol 1,4,5-Trisphosphate; D010739:Phospholipase D; D002118:Calcium
Plastichnost' kholinoretseptorov neĭronov vinogradnoĭ ulitki posle vozdeĭstviĭ na zavismuiu ot inozitol-1,4,5-trifosfata i Ca2(+) mobilizatsiiu deponirovannogo Ca2(+) i uroven' fosfatidnoĭ kisloty.