title: Synthesis and analgesic activity of new phencyclidine derivatives.
abstract: New phencyclidine derivatives having structural similarities with the well known 4-phenylpiperidine narcotic analgesics were synthesized characterized and their anti-nociceptive activity tested in mice by the hot-plate and tail-flick tests. Structure-activity relationships for these compounds further point to the importance of a second aryl moiety at position 4 of the piperidine ring of phencyclidine. In addition, the presence of a hydroxyl group in close proximate to the lipophilic moiety is vital for analgesic activity.
authors: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: O A
authors: OA
authors: al-Deeb
mesh_terms: D000700:Analgesics / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006358:Hot Temperature; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D013329:Structure-Activity Relationship; D013375:Substance Withdrawal Syndrome / Q000523:psychology
chemical_list: D000700:Analgesics; D009270:Naloxone; D009020:Morphine; D010622:Phencyclidine