Familial risks for Alzheimer disease from a population-based series.
Kaplan-Meier risks estimates are calculated and compared for two consecutive series (N1 = 840, N2 = 819) of first-degree relatives of Alzheimer disease (AD) patients diagnosed as either "probable" or "autopsy-confirmed" AD. The consistency of results increases confidence in estimates and suggests consistent case ascertainment over 8 years. Lifetime risk estimates to age 88 for the combined sample (23.4% +/- 3.0%) do not approach the 50% risk compatible with an autosomal dominant model of transmission. These results support our previous finding and suggest that an autosomal dominant gene(s) is not responsible for all cases of AD.
Hirst
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Department of Medical Genetics, University Hospital-UBC Site, University of British Columbia, Vancouver, Canada.
Yee
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Sadovnick
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AD
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D015982:Bias; D001955:British Columbia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008957:Models, Genetic; D017720:Molecular Epidemiology; D009017:Morbidity; D010375:Pedigree; D011159:Population Surveillance; D016016:Proportional Hazards Models; D012307:Risk Factors