title: Lymphocyte membrane modifications induced by HIV infection.
abstract: Novel carbohydrate antigen expressions were observed on T lymphocytes from HIV infected patients using flowcytometric analysis with four mAbs; BM-1, ACFH-18, FH-2 and C-6. These carbohydrate antigens were also expressed on oncogenic transformed cells but were either not expressed or were weakly expressed in lymphocyte populations from healthy subjects. A dramatic change in glycosylation was induced on CD8+T cells from HIV infected patients. The glycosylation change correlated with the progression of the disease. The incidence of Ley antigen expression on CD8+T cells increased as the disease progressed with the ongoing impairment of immune function. The phenotype change that occurred with Ley antigen expression might reflect the abnormal activation of T lymphocytes of some specific, but unknown, population of CD8+T cells. Thus, carbohydrate changes on the cell surface may induce immunological abnormality and accelerate the damage within the CD4+T cell subset, resulting in an impairment of the antigen specific immune system.
authors: Department of Medical Biochemistry, Foothills Hospital, University of Calgary, Alberta, Canada.
authors: N
authors: N
authors: Kashiwagi
authors: M J
authors: MJ
authors: Gill
authors: M
authors: M
authors: Adachi
authors: D
authors: D
authors: Church
authors: S J
authors: SJ
authors: Wong
authors: M C
authors: MC
authors: Poon
authors: S
authors: S
authors: Hakomori
authors: T
authors: T
authors: Tamaoki
authors: C
authors: C
authors: Shiozawa
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001773:Blood Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002241:Carbohydrates / Q000276:immunology; D002460:Cell Line; D002462:Cell Membrane / Q000648:ultrastructure; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000097:blood / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D016256:Lewis X Antigen / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D002241:Carbohydrates; D016256:Lewis X Antigen