title: High cerebrospinal fluid and serum levels of tumor necrosis factor-alpha in asymptomatic HIV-1 seropositive individuals. Correlation with interleukin-2 and soluble IL-2 receptor.
abstract: The relationship between tumour necrosis factor-alpha (TNF-alpha) and the interleukin-2 (ILL-2) system in HIV-1 infection is important in understanding the dynamics of early immune response before the development of acquired immunodeficiency syndrome. Levels of TNF-alpha, IL-2 and soluble IL-2 receptor (sIL-2R) in serum and cerebrospinal fluid (CSF) samples from 31 asymptomatic HIV-1 seropositive individuals were measured. High levels of TNF-alpha were detected in CSF of 17 (55%) and serum of 22 (71%) subjects, 15 (88%) of whom had elevated CSF IL-2 levels and 16 (94%) had high sIL-2R levels. Moreover, CSF levels of TNF-alpha significantly correlated with CSF levels of IL-2 and sIL-2R. TNF-alpha, IL-2 and sIL-2R seem to be released within the intrathecal compartment early in the course of HIV-1 infection. In view of the known cytotoxic effects of TNF-alpha, an early release may contribute to subsequent development of neurological complications.
authors: Institute of Infectious Diseases, University of Rome, La Sapienza, Italy.
authors: M
authors: M
authors: Ciardi
authors: M K
authors: MK
authors: Sharief
authors: E J
authors: EJ
authors: Thompson
authors: A
authors: A
authors: Salotti
authors: V
authors: V
authors: Vullo
authors: F
authors: F
authors: Sorice
authors: A
authors: A
authors: Cirelli
mesh_terms: D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D006679:HIV Seropositivity / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007376:Interleukin-2 / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000134:cerebrospinal fluid
chemical_list: D002556:Cerebrospinal Fluid Proteins; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha