Bronchodilator activity of theophylline derivatives substituted at the 7-position.
Theophylline derivatives with several groups linked at the 7-position were synthesized and their pharmacological activities were studied on guinea pig. Relaxant action in the tracheal muscle was increased in comparison with that of theophylline when the 3(2H)-pyridazinone system was linked to 7-(2-ethyl)-theophylline through the piperazine ring, but decreased when the 7-(2-ethyl)-theophylline was linked to 3(2H)-pyridazinone ring through an amino group.
Corsano
S
S
Institute of Pharmaceutical Chemistry, University of Perugia, Italy.
Scapicchi
R
R
Strappaghetti
G
G
D000818:Animals; D001993:Bronchodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D001993:Bronchodilator Agents; D013806:Theophylline