Monte Carlo simulation of ligand-receptor interactions on a cell surface.
In this paper we develop a compartmentalized, discrete simulation model for investigating the spatial distribution and dynamic properties of receptor crosslinking on the surface of a cell. Results generated by the model are compared with some of the major results of existing analytical models, and differences are discussed in relation to differences in the model assumptions. Finally, the model is used to evaluate the dynamic effects of a time-varying non-homogeneous ligand concentration.
Weinand
R
R
Department of Computer Science, Wayne State University, Detroit, MI 48202.
Sengstock
D M
DM
Rosenspire
A J
AJ
D004058:Diffusion; D008024:Ligands; D046911:Macromolecular Substances; D008560:Membrane Fluidity; D008962:Models, Theoretical; D009010:Monte Carlo Method; D011940:Receptor Aggregation; D011956:Receptors, Cell Surface / Q000502:physiology*
D008024:Ligands; D046911:Macromolecular Substances; D011956:Receptors, Cell Surface