Thrombocytopenia associated with platelet-associated immunoglobulin G in alcoholic hepatitis.
A 45 year old Japanese man with alcoholic hepatitis developed thrombocytopenia together with an increase in the level of platelet-associated immunoglobulin G (PAIgG). Bone marrow aspiration revealed a normal nucleated cell count and a slight increase of megakaryocytes. After abstinence from alcohol, laboratory and symptomatic improvement occurred in association with a prompt increase in the platelet count and a corresponding decrease of PAIgG. These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.
Kamisako
T
T
Second Department of Internal Medicine, Kinki University School of Medicine, Osakasayama, Japan.
Saika
Y
Y
Adachi
Y
Y
Itoh
T
T
Fujii
R
R
Yamamoto
T
T
D001792:Blood Platelets / Q000276:immunology*; D006519:Hepatitis, Alcoholic / Q000150:complications* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013921:Thrombocytopenia / Q000209:etiology / Q000276:immunology*
D007074:Immunoglobulin G