Biochemical markers of nutrition in type-I and type-II osteoporosis.
We studied nutritional deficits, using as markers the levels of transferrin, retinol-binding protein, and prealbumin, in 20 women with osteoporotic hip fractures (type II), 40 women with vertebral fractures (type I), and two groups of age-matched control subjects. The concentrations of all three nutritional markers were lower in the two groups of patients than in their matched controls, and in type-I as compared with type-II osteoporosis. In the osteoporotic patients, simple linear regression showed a significant correlation between the variables which we studied (r2 ranged from 0.5 to 0.7; p < 0.001), the best correlation being between prealbumin and retinol-binding protein in type-II osteoporosis. Our results suggest that there is a more marked nutritional deficit in type-II than in type-I osteoporosis.
Rico
H
H
Department of Medicine, School of Medicine, Universidad de Alcalá de Henares, Madrid, Spain.
Relea
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P
Crespo
R
R
Revilla
M
M
Villa
L F
LF
Arribas
I
I
Usabiaga
J
J
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D016014:Linear Models; D009748:Nutrition Disorders / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D009752:Nutritional Status; D010024:Osteoporosis / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D011228:Prealbumin / Q000032:analysis; D012177:Retinol-Binding Proteins / Q000032:analysis; D014168:Transferrin / Q000032:analysis
D015415:Biomarkers; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D014168:Transferrin