Dissolution kinetics of griseofulvin in mixed micellar solutions.
The dissolution kinetics of the poorly water soluble, lipophilic model drug substance griseofulvin were studied in solutions containing simple and mixed micelles of sodium cholate (BS) and phosphatidylcholine (PC). Variables under investigation were the concentration of BS and the ratio PC/BS. A rotating disk apparatus was used to monitor the dissolution process. With this method, (mixed) micellar diffusion coefficients could be calculated and some detailed information about the physicochemical behavior and composition of mixed PC/BS micelles could be derived.
de Smidt
J H
JH
Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, The Netherlands.
Grit
M
M
Crommelin
D J
DJ
D001647:Bile Acids and Salts; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019826:Cholic Acid; D002793:Cholic Acids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D006118:Griseofulvin / Q000737:chemistry*; D007700:Kinetics; D008823:Micelles; D010713:Phosphatidylcholines / Q000737:chemistry; D012995:Solubility; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
D001647:Bile Acids and Salts; D002793:Cholic Acids; D008823:Micelles; D010713:Phosphatidylcholines; D012996:Solutions; D006118:Griseofulvin; D019826:Cholic Acid