Vascular mineralization in the monkey brain.
Mineralization of various degrees was found in the brains of 79 (59%) of 134 cynomolgus monkeys (Macaca fascicularis). There was no age dependency in the incidence or severity, nor were there any abnormalities in growth, weight gain, or neurologic signs, although a slight sex difference was observed. The lesions, which were basophilic and intensely positive for periodic acid-Schiff or von Kossa stain, occurred in the vascular walls of the globus pallidus in two types: globoid bodies with prominent concentric lamellar structures in and around the arteriolar and venular wall (type A) and fine granules in the media of small or medium-sized arteries (type B). Electron microscopic examination revealed dense deposits in the degenerated media of small or medium-sized arteries or the thickened walls of the arterioles. X-ray microanalysis demonstrated the presence of calcium, phosphorus, iron, zinc, magnesium, and aluminum.
Yanai
T
T
Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.
Masegi
T
T
Ueda
K
K
Manabe
J
J
Teranishi
M
M
Takaoka
M
M
Matsunuma
N
N
Fukuda
K
K
Goto
N
N
Fujiwara
K
K
D000818:Animals; D002114:Calcinosis / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005917:Globus Pallidus / Q000098:blood supply* / Q000473:pathology*; D008252:Macaca fascicularis; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D008992:Monkey Diseases / Q000473:pathology*