title: Trimethylsilylated trifluoromethyl ketones, a novel class of acetylcholinesterase inhibitors: biochemical and pharmacological profile of MDL 73,745.
authors: Marion Merrell Dow Research Institute, Strasbourg, France.
authors: J M
authors: JM
authors: Hornsperger
authors: J N
authors: JN
authors: Collard
authors: J G
authors: JG
authors: Heydt
authors: E
authors: E
authors: Giacobini
authors: S
authors: S
authors: Funes
authors: J
authors: J
authors: Dow
authors: D
authors: D
authors: Schirlin
mesh_terms: D000098:Acetophenones / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000110:Acetylcholinesterase / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014297:Trimethylsilyl Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000098:Acetophenones; D002800:Cholinesterase Inhibitors; D014297:Trimethylsilyl Compounds; C082826:zifrosilone; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase