Effects of a positively charged biomaterial for dermal and subcutaneous augmentation.
Based on previous experimental connective tissue work, the use of a positively charged dextran-based biomaterial in subcutaneous tissue sites was evaluated. After hydration with saline, the biomaterial was injected beneath the abdominal skin in rats. A robust macrophage response was initially seen at 30 days without acute inflammation. By one year postoperatively, extensive intermaterial fibroblast and collagen ingrowth had occurred. No evidence of a foreign-body or chronic inflammatory response was seen. These preliminary findings suggest good tissue compatibility of this biomaterial and suggests that when combined with a biocompatible liquid medium, the potential for development of a bioactive dermal and subcutaneous injectable substance exists.
Eppley
B L
BL
Division of Plastic and Reconstructive Surgery, Indiana University Medical Center, Indianapolis 46202-5200.
Summerlin
D J
DJ
Prevel
C D
CD
Sadove
A M
AM
D000818:Animals; D002412:Cations; D003094:Collagen / Q000276:immunology; D003238:Connective Tissue / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D003637:DEAE-Dextran / Q000494:pharmacology / Q000627:therapeutic use*; D062109:Dermatologic Surgical Procedures; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D007279:Injections, Subcutaneous; D008264:Macrophages / Q000276:immunology; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000276:immunology / Q000473:pathology; D013518:Surgery, Plastic / Q000379:methods*; D014945:Wound Healing
D002412:Cations; D003094:Collagen; D003637:DEAE-Dextran