title: Expression of alpha and beta thyroid receptors during oligodendrocyte differentiation.
abstract: To determine which thyroid receptor (TR) isoforms are expressed during oligodendrocyte differentiation, we studied the expression of the mRNAs encoding two alpha (alpha 1 and alpha 2) and one beta (beta 1) TR isoforms in a bipotential oligodendrocyte-type 2-astrocyte (O-2A) progenitor cell line (CG-4) as well as in rat O-2A progenitor cells and oligodendrocytes. O-2A progenitor cells expressed only TR alpha-mRNAs, whereas oligodendrocytes and type 2-astrocytes also expressed TR beta 1-mRNAs. The differential expression of alpha 1 and beta 1 TRs suggests specific functions for both types of TRs during oligodendrocyte differentiation. We present evidence for a possible role of TR alpha 1 in the effect of thyroid hormones on the proliferation of CG-4 cells maintained as progenitor cells.
authors: Unité de Médecine Génétique et Moléculaire, Centre de recherche du CHU Laval, Sainte-Foy, Québec, Canada.
authors: D
authors: D
authors: Baas
authors: D
authors: D
authors: Bourbeau
authors: J L
authors: JL
authors: Carre
authors: L L
authors: LL
authors: Sarlieve
authors: J H
authors: JH
authors: Dussault
authors: J
authors: J
authors: Puymirat
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015152:Blotting, Northern; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D007536:Isomerism; D009457:Neuroglia / Q000378:metabolism; D009836:Oligodendroglia / Q000378:metabolism / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D011988:Receptors, Thyroid Hormone / Q000096:biosynthesis*; D013234:Stem Cells / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D011988:Receptors, Thyroid Hormone; D013936:Thymidine