Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study.
The effects of acute intraperitoneal administration of ethanol (1-3 g/kg body wt) on the extracellular concentrations of glutamate (GLU), taurine (TAU) and gamma-aminobutyric acid (GABA) in rat brain nucleus accumbens were studied by the microdialysis technique coupled to HPLC-EC detection. Levels of GLU and GABA were not affected by ethanol, whereas those of TAU were increased by doses of the drug of 2-3 g/kg.
Dahchour
A
A
Laboratoire de Psychobiologie, Université de Louvain, Belgium.
Quertemont
E
E
De Witte
P
P
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol / Q000008:administration & dosage; D018698:Glutamic Acid / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D017551:Microdialysis; D009714:Nucleus Accumbens / Q000187:drug effects / Q000503:physiopathology*; D051381:Rats; D013654:Taurine / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D013654:Taurine; D000431:Ethanol; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid