Multiple serotonin receptors: clinical and experimental aspects.
Serotonin (5-hydroxytryptamine; 5-HT) has been implicated in a large number of psychophysiologic processes including the regulation of sleep, appetite, mood, aggression, perception, memory, and anxiety. To mediate this large array of physiologic processes, at least 14 separate 5-HT receptors have evolved, which are divided into seven main families. Not surprisingly, alterations of 5-HT receptor activity have been shown to occur in many psychiatric diseases including anxiety, depression, eating disorders, schizophrenia, personality disorders, and many drug-induced psychotic states. Additionally, a number of effective psychopharmacologic agents for diseases as diverse as schizophrenia and anxiety have been developed which either specifically alter brain levels of serotonin or bind to 5-HT receptor subtypes. This review article summarizes recent advances in the burgeoning field of serotonin receptor pharmacology and integrates this information into a coherent perspective on the importance of serotonergic agents for clinical psychiatry.
Roth
B L
BL
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001931:Brain Mapping; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D011985:Receptors, Serotonin / Q000145:classification* / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012701:Serotonin / Q000502:physiology; D018490:Serotonin Agents / Q000627:therapeutic use
D014150:Antipsychotic Agents; D011985:Receptors, Serotonin; D018490:Serotonin Agents; D012701:Serotonin