title: Inhibitory effects of purified eicosapentaenoic acid and docosahexaenoic acid on growth and metastasis of murine transplantable mammary tumor.
abstract: We studied the effects of purified linoleic acid, eicosapentaenoic acid(EPA) and docosahexaenoic acid (DHA) on mammary tumor MM48 the transplanted into C3H/He mice. The growth of the primary tumor was significantly inhibited in EPA- and DHA-treated groups as compared with control and/or linoleic acid-treated groups (p < 0.05). The number of metastatic tumors in the lungs tended to be inhibited in the EPA- and DHA-treated groups and promoted in the linoleic acid-treated group, as compared with the control group, but not to a statistically significant extent. The EPA-treated group survived significantly longer than the control group (p = 0.002), while the DHA-treated group survived longer than the control group although the difference was not significant (p = 0.070). However, there was no significant difference between EPA- and DHA-treated groups on primary tumor growth, number of lung metastases or survival time of animals.
authors: Department of Surgery(II), Kanazawa University Hospital, School of Medicine, Japan.
authors: K
authors: K
authors: Kinoshita
authors: M
authors: M
authors: Noguchi
authors: M
authors: M
authors: Earashi
authors: M
authors: M
authors: Tanaka
authors: T
authors: T
authors: Sasaki
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004281:Docosahexaenoic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D015118:Eicosapentaenoic Acid / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006131:Growth Inhibitors / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D015996:Survival Rate
chemical_list: D006131:Growth Inhibitors; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid