title: Detection of lymph node metastases of squamous-cell cancer of the head and neck with FDG-PET and MRI.
abstract: The uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) in neck lymph nodes of twelve patients with a squamous-cell carcinoma of the oral cavity was studied with PET in order to detect and locate lymphogenic metastases.
  
  
  METHODS
  The results of FDG-PET imaging were compared with clinical, MRI and histopathologic findings. Standardized uptake values (SUV) were also calculated.
  
  
  RESULTS
  A sensitivity of 91% and a specificity of 88% were calculated for FDG-PET. In contrast, a sensitivity of 36% and a specificity of 94% were calculated for MRI. Calculated SUVs for reactive lymph nodes, metastatic lymph nodes and the primary tumor were undifferentiated.
  
  
  CONCLUSIONS
  Using FDG-PET, lymph node metastases of squamous-cell carcinomas of the oral cavity can be visualized with a high sensitivity and specificity. FDG-PET can be an improvement in the evaluation of the neck.
authors: Department of Oral and Maxillofacial Surgery, National Research PET Center, Groningen, The Netherlands.
authors: J W
authors: JW
authors: Braams
authors: J
authors: J
authors: Pruim
authors: N J
authors: NJ
authors: Freling
authors: P G
authors: PG
authors: Nikkels
authors: J L
authors: JL
authors: Roodenburg
authors: G
authors: G
authors: Boering
authors: W
authors: W
authors: Vaalburg
authors: A
authors: A
authors: Vermey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D011877:Radionuclide Imaging
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose