title: Effectiveness of intraoperative mitomycin C in the treatment of recurrent pterygium.
abstract: The effectiveness of intraoperative administration of mitomycin C and the occurrence of postoperative complications have been evaluated in 30 white patients with one recurrence of pterygium. The authors employed the 'bare-sclera technique' and, intraoperatively, placed in the episcleral space for 3 min a sterile sponge soaked in a 4% mitomycin C solution. The control group (30 patients with one recurrent pterygium) underwent only surgical excision. Statistical analysis performed using the chi-square test showed a significant (p = 0.024) reduction of recurrences of pterygium in the group treated intraoperatively with mitomycin C. No heavy side effects occurred during the follow-up period. Mitomycin C, administered intraoperatively, may be considered an effective treatment to improve the success rate after surgical excision.
authors: Institute of Ophthalmology, University G. D'Annunzio, Chieti, Italy.
authors: L
authors: L
authors: Mastropasqua
authors: P
authors: P
authors: Carpineto
authors: M
authors: M
authors: Ciancaglini
authors: L
authors: L
authors: Lobefalo
authors: P E
authors: PE
authors: Gallenga
mesh_terms: D000328:Adult; D004341:Drug Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects / Q000627:therapeutic use*; D011183:Postoperative Complications; D011625:Pterygium / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D012008:Recurrence
chemical_list: D016685:Mitomycin