title: [In vitro bactericidal activity of seven antibiotics and four combinations against Neisseria meningitidis].
abstract: The authors studied, with a time-kill curve method, in a derived Hafiz medium broth the bactericidal effect of 7 antibiotics and 4 associations against N. meningitidis. Their results show a better bactericidal effect for penicillin G, ampicillin and chloramphenicol. Pefloxacin and ceftriaxon are less efficient. The association ampicillin + chloramphenicol in vitro shows no antagonism and has a good bactericidal activity at the early stages of bactericidal killing with N. meningitidis.
authors: Laboratoire de Biologie Médicale, HIA Begin, Saint-Mandé, France.
authors: J Y
authors: JY
authors: Nizou
authors: J D
authors: JD
authors: Cavallo
authors: Y
authors: Y
authors: Crenn
authors: M
authors: M
authors: Bartoli
authors: M
authors: M
authors: Meyran
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D066298:In Vitro Techniques; D009345:Neisseria meningitidis / Q000187:drug effects*; D015366:Pefloxacin / Q000494:pharmacology*; D010400:Penicillin G / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D015572:Spiramycin / Q000494:pharmacology
chemical_list: D015366:Pefloxacin; D002701:Chloramphenicol; D002443:Ceftriaxone; D000667:Ampicillin; D015572:Spiramycin; D010400:Penicillin G; D012293:Rifampin
vernacular_title: Activité bactéricide in vitro de sept antibiotiques et de quatre associations sur Neisseria meningitidis.