title: Detection of antibodies to defined M. tuberculosis antigen (38 kDa) in cerebrospinal fluids of patients with tuberculous meningitis.
abstract: Antibodies to the 38 kDa antigen of M. tuberculosis which is serospecific to the tuberculosis complex group of organisms was studied in CSF samples of patients with tuberculosis meningitis. Patients were classified into four groups, viz. post-mortem-proved, culture-proved, clinically suspected and tuberculoma. Anti-38 kDa antibody was detected by ELISA and was positive in 60%, 80% 62.5% and 0%, respectively in the four groups. Controls showed a false-positive detection of 5%. Follow-up of patients was done up to 6 weeks and antibody levels dropped in all the patient groups.
authors: Radiation Medicine Center, Tata Memorial Center Annexe, Parel, Bombay, India.
authors: G V
authors: GV
authors: Kadival
authors: M
authors: M
authors: Kameswaran
authors: R
authors: R
authors: Doshi
authors: S S
authors: SS
authors: Todiwala
authors: A M
authors: AM
authors: Samuel
mesh_terms: D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D008970:Molecular Weight; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D012698:Serologic Tests; D014390:Tuberculosis, Meningeal / Q000175:diagnosis*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial