title: Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells.
abstract: We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells. The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors. The observed early effects of Curcumin were mediated via a cellular mechanism(s), and preceded the period when inhibition of cell growth occurred.
authors: Department of Medicine, Pennsylvania State University College of Medicine, Hershey 17033.
authors: L
authors: L
authors: Korutla
authors: R
authors: R
authors: Kumar
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D010766:Phosphorylation; D014407:Tumor Cells, Cultured
chemical_list: D066246:ErbB Receptors; D003474:Curcumin