Glycogenic effect of an alkali soluble fraction from sepia shell.
The alkali soluble fraction of the sepia shell possesses both anticonvulsant and hypoglycemic effect. The investigation regarding the fate of the blood sugar during the hypoglycemia revealed that the sepia shell extract acts as a glycogenic agent by mobilising the blood sugar towards liver glycogen reserve through the modulation of the enzymes glycogen phosphorylase a and ab in normal and streptozotocin diabetic mice. The glucose tolerance test (GTT) showed a depression in the GTT curve in experimental mice. The available literature on the biochemistry of the shell reveals that it contains glucosamines and some amino acid residues. The presence of amine group may resemble the sulfonylureas like tolbutamide which also possesses both anticonvulsant and hypoglycemic effect.
Reddy
T N
TN
Department of Zoology, Osmania University, Hyderabad, India.
Reddy
C P
CP
Srinivas
V
V
Divan
P V
PV
Reddy
P U
PU
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051379:Mice; D006005:Phosphorylases / Q000378:metabolism
D007004:Hypoglycemic Agents; D006003:Glycogen; D006005:Phosphorylases