title: Positional distribution of fatty acids in dietary triglycerides: effects on fasting blood lipoprotein concentrations in humans.
abstract: We examined the effect of the positional distribution of fatty acids within dietary triglycerides on serum lipoproteins. Sixty subjects consumed two diets of equal fatty acid composition for 3 wk each. In the palm oil diet 82% of palmitic acid was attached to the outer two carbon atoms of glycerol, and 18% to the middle carbon. In the diet rich in enzymatically modified palm oil these figures were 35% and 65%, respectively. On the modified-fat diet, average lipoprotein concentrations showed nonsignificant (P > 0.13) increases of 0.06 mmol/L for total, 0.03 mmol/L for HDL, and 0.04 mmol/L for LDL cholesterol compared with palm oil. The small increases in total and LDL cholesterol were statistically significant in the men (n = 23) but not in the women (n = 37). The ratio of HDL to LDL cholesterol and serum triglyceride concentrations were unchanged. Thus, a large difference in dietary fatty acid configuration had little effect on lipoprotein concentrations in humans.
authors: Department of Human Nutrition, Wageningen Agricultural University, Netherlands.
authors: P L
authors: PL
authors: Zock
authors: J H
authors: JH
authors: de Vries
authors: N J
authors: NJ
authors: de Fouw
authors: M B
authors: MB
authors: Katan
mesh_terms: D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000494:pharmacology*; D005215:Fasting; D005227:Fatty Acids / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000073878:Palm Oil; D010938:Plant Oils / Q000494:pharmacology*; D013237:Stereoisomerism; D014280:Triglycerides / Q000008:administration & dosage* / Q000097:blood
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D010938:Plant Oils; D014280:Triglycerides; D000073878:Palm Oil; D002784:Cholesterol