title: Excitotoxicity and cholinergic chemical markers during programmed motor neurone death.
abstract: We measured cholinergic markers and acetylcholinesterase (AChE) molecular forms after glutamate receptor stimulation of superfused slices of mouse spinal cord at different developmental ages. AChE globular forms were secreted in a dose-dependent fashion. A period of selective sensitivity to excitotoxic agents was detected by increased acetylcholine (ACh) release and AChE secretion (sAChE) at postnatal day 14. Strychnine-resistant glycine stimulation potentiated glutamate-induced AChE release, suggesting N-methyl-D-aspartate (NMDA) receptor involvement.
authors: Division of Neuromyology, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Montevideo, Uruguay.
authors: D
authors: D
authors: Rodríguez-Ithurralde
authors: O
authors: O
authors: Vincent
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers; D018846:Excitatory Amino Acids / Q000633:toxicity*; D018698:Glutamic Acid / Q000378:metabolism; D051379:Mice; D009046:Motor Neurons / Q000201:enzymology / Q000378:metabolism* / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000201:enzymology / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000201:enzymology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018846:Excitatory Amino Acids; D017470:Receptors, Glutamate; D018698:Glutamic Acid; D000110:Acetylcholinesterase; D000109:Acetylcholine