[Effects of phenytoin and cabamazepine on sex hormones in male patients with epilepsy: a controlled study].
We measured the levels of estradiol (E2), total testosterone (TT) and free testosterone (FT) in 24 male patients with epilepsy receiving phenytoin (DPH), 21 male patients with epilepsy receiving cabamazepine (CBZ), 23 male epileptics receiving no treatment, and in 10 healthy age-matched male controls. The FT and TT levels of the DPH group were significantly lower and higher than those of the normal control group, respectively. The E2, FT and TT of the CBZ group were all lower than those of the normal controls. The results showed the difference between DPH and CBZ in the mechanism of affecting the levels of sex hormones; therefore, the treatments should not be the same.
Ma
S
S
Zhou
S
S
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000627:therapeutic use*; D016022:Case-Control Studies; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D004958:Estradiol / Q000097:blood*; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood*
D002220:Carbamazepine; D013739:Testosterone; D004958:Estradiol; D010672:Phenytoin