title: Glycyrrhizin and 18 beta-glycyrrhetinic acid: a comparative study of the pharmacological effects induced in the rat after prolonged oral treatment.
abstract: Recent clinical and toxicological studies have investigated the mineralcorticoid-like and hypertensive effects of liquorice, and we therefore set out to identify the active component responsible for these effects. We conducted a 30-day comparative analysis of glycyrrhizin and 18 beta-glycyrrhetinic acid and found that the latter causes significant variations both in systolic blood pressure and in the excretion in the urine of Ca++. The effects were fully reversible on suspension of treatment.
authors: Department of Pharmaceutical Sciences, University of Modena, Italy.
authors: T
authors: T
authors: Rossi
authors: G
authors: G
authors: Vampa
authors: S
authors: S
authors: Benvenuti
authors: L A
authors: LA
authors: Pini
authors: I
authors: I
authors: Galatulas
authors: R
authors: R
authors: Bossa
authors: M
authors: M
authors: Castelli
authors: A I
authors: AI
authors: Ruberto
authors: G
authors: G
authors: Baggio
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019695:Glycyrrhizic Acid; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid; D002118:Calcium