Antigravitropic activity of 2-(2-arylamino-1,2-dioxoethyl) benzoic acid methyl esters.
Methylation of 1,3-dihydro-1-hydroxy-3-oxo-1-isobenzofurancarboxamides (A-I) yields 2-(2-arylamino-1,2-dioxoethyl)benzoic acid methylesters. The esters 1-7 allowed the evaluation of the intrinsic activity of 2-(2-arylamino-1,2-dioxoethyl)benzoic structure, to whom the antigravitropic effect of the carboxamides A-I may be probably assigned. The comparison of activities of methylesters 1-7 (B) and 8-14 (C) shows how conformational differences as those between the arylamino-1,2-dioxoethylic portion of B and the arylamino-2-oxoethylic portion of C may deeply effect phytotropin interaction with the receptor site.
Modena
T
T
Pavanetto
F
F
Mazza
M
M
D001565:Benzoates / Q000138:chemical synthesis / Q000494:pharmacology*; D019817:Benzoic Acid; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology; D006112:Gravitation; D012639:Seeds; D013329:Structure-Activity Relationship
D001565:Benzoates; D004952:Esters; D019817:Benzoic Acid