title: Severe granular dystrophy: a pedigree with presumed homozygotes.
abstract: Three siblings with severe granular corneal dystrophy are described. They are most likely to be homozygous for the dominantly inherited gene. They are offspring of a consanguineous marriage, with both parents affected with corneal dystrophies. The case reports describe the severe course of this condition, requiring multiple grafting procedures. Clinical pictures of the family are shown.
authors: C J
authors: CJ
authors: Diaper
mesh_terms: D000293:Adolescent; D001766:Blindness / Q000209:etiology; D002648:Child; D003317:Corneal Dystrophies, Hereditary / Q000150:complications / Q000235:genetics* / Q000601:surgery; D016039:Corneal Transplantation; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012008:Recurrence; D014792:Visual Acuity