[Does the endocrinal milieu influence the expression and/or the action of ovarian growth factors in polycystic ovary syndrome?].
Polycystic Ovary Syndrome (PCOS) results from endocrine, paracrine and autocrine dysfunction, affecting thecal and granulosa cells. The circulating insulin/IGF system is often dysregulated in PCOS. It could influence the local IGFs/IGF-BPs system, when granulosa, and more putatively thecal cells depend on. It is a new field of research about the physiopathology of PCOS, lying on clinical grounds. However, its practical interest is still limited.
Dewailly
D
D
Service d'endocrinologie, CHRU de Lille.
Cortet-Rudelli
C
C
D005260:Female; D006107:Granulosa Cells / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D013002:Somatomedins / Q000502:physiology*; D013799:Theca Cells / Q000502:physiology
D007328:Insulin; D013002:Somatomedins
Le milieu endocrinien influence-t-il l'expression et/ou l'action des facteurs de croissance ovariens dans le syndrome des ovaires polykystiques?