Immediate and long-term effects of daily glycerol administration on guinea pig hydropic ears.
Oral administration of glycerol at 0.5 g/kg and 1.0 g/kg body weight in the guinea pig with experimentally induced hydrops provoked no obvious modifications of the CAP audiogram within a 3-h recording session. Daily administration of glycerol at the same dose level during a 4-month period did not modify the deterioration of CAP thresholds although some limited beneficial effect was detected for some animals after 8 weeks of treatment.
Huang
W
W
Department of Otorhinolaryngology, Beijing Hospital, People's Republic of China.
Erre
J P
JP
Horner
K C
KC
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001299:Audiometry; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D018159:Endolymphatic Hydrops / Q000188:drug therapy* / Q000503:physiopathology; D005990:Glycerol / Q000008:administration & dosage*; D006168:Guinea Pigs; D013997:Time Factors
D005990:Glycerol