Disturbances of cementum formation induced by single injection of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) in rats: light and scanning electron microscopic studies.
With the rat molar as a model, evidence is presented that dentin mineralization influences formation of acellular cementum. Formation of acellular cementum did not occur on the surface of experimentally induced unmineralized dentin. Instead, an atypical hyperplastic cementum was formed. The disturbance in acellular cementum formation was permanent.
Alatli-Kut
I
I
Department of Oral Pathology, School of Dentistry, Karolinska Institutet, Huddinge, Sweden.
Hultenby
K
K
Hammarström
L
L
D000818:Animals; D003739:Dental Cementum / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D003743:Dental Enamel / Q000187:drug effects / Q000473:pathology; D003804:Dentin / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D004195:Disease Models, Animal; D012968:Etidronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D006965:Hyperplasia; D007279:Injections, Subcutaneous; D008855:Microscopy, Electron, Scanning; D008963:Molar; D009805:Odontogenesis / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014074:Tooth Calcification / Q000187:drug effects / Q000502:physiology; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology / Q000502:physiology
D012968:Etidronic Acid