Evaluation of topical ibuprofen cream in the treatment of acute ankle sprains.
One hundred patients who presented to the accident and emergency (A&E) department with an acute ankle sprain were entered into a study to determine the efficacy of topical ibuprofen cream by using a double-blind placebo controlled design in a single type of soft-tissue injury. The subjects were given either topical ibuprofen cream or a placebo cream in addition to the standard management of the department. Patients kept diaries recording walking ability and pain visual analogue scales for resting, standing and walking. A total of 51 patients returned diaries that were suitable for analysis. Patients using the topical ibuprofen cream had significant reduction in pain scores over the first 48 h of treatment.
Campbell
J
J
Accident and Emergency Department, St John's Hospital at Howden, Livingston.
Dunn
T
T
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D016512:Ankle Injuries / Q000188:drug therapy*; D004311:Double-Blind Method; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D013180:Sprains and Strains / Q000188:drug therapy*
D009824:Ointments; D007052:Ibuprofen