Increased frequency of micronuclei in lymphocytes of Swedish chimney sweeps.
Forty-five Swedish chimney sweeps and 49 controls were investigated with micronuclei stimulated by phytohemagglutinin and pokeweed mitogen and by analysis of lymphocyte subgroups and neutrophilic leukocytes. There was a statistically significant effect among sweeps with respect to both micronuclei variables and neutrophilic leukocytes. The effect on lymphocyte micronuclei was most prominent in pokeweed mitogen-stimulated cells, which may imply that the T4 lymphocytes were preferentially damaged by the occupational exposure.
Holmén
A
A
Department of Occupational Medicine, Central Hospital, Halmstad, Sweden.
Karlsson
A
A
Bratt
I
I
Raihle
G
G
Högstedt
B
B
D000293:Adolescent; D000328:Adult; D001194:Asbestos / Q000009:adverse effects; D001402:B-Lymphocytes / Q000276:immunology / Q000648:ultrastructure*; D001564:Benzo(a)pyrene / Q000009:adverse effects; D006801:Humans; D015162:Micronucleus Tests; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D016273:Occupational Exposure / Q000009:adverse effects*; D012907:Smoking / Q000009:adverse effects; D013548:Sweden / Q000453:epidemiology; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure*
D001194:Asbestos; D001564:Benzo(a)pyrene