Successful treatment of Finnish congenital nephrotic syndrome with captopril and indomethacin.
Two infants with biopsy-proven microcystic Finnish congenital nephrotic syndrome (onset at birth) were treated with a combination of captopril and indomethacin for 2 1/2 and 2 years, respectively; they had a marked reduction of urinary protein excretion without further need for albumin infusions. One infant has end-stage renal disease; the other infant's glomerular filtration rate has remained within normal limits.
Pomeranz
A
A
Department of Nephrology, Meir General Hospital, Kfar Saba, Israel.
Wolach
B
B
Bernheim
J
J
Korzets
Z
Z
Bernheim
J
J
D002216:Captopril / Q000627:therapeutic use*; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D007668:Kidney / Q000503:physiopathology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000503:physiopathology; D016030:Kidney Transplantation; D008297:Male; D009392:Nephrectomy; D009404:Nephrotic Syndrome / Q000151:congenital* / Q000188:drug therapy* / Q000503:physiopathology; D011507:Proteinuria / Q000652:urine
D002216:Captopril; D007213:Indomethacin