Phenelzine reduces plasma vitamin B6.
Plasma levels of the active form of vitamin B6 (pyridoxal phosphate) in 19 patients taking phenelzine were found to be reduced on the average to approximately 54% of the value in a control group. There was no correlation of pyridoxal phosphate level with phenelzine daily dosage over the range of 30 mg to 90 mg. No symptoms of vitamin B6 deficiency peripheral neuropathy were found.
Malcolm
D E
DE
Department of Psychiatry, Royal University Hospital, Saskatoon, Saskatchewan.
Yu
P H
PH
Bowen
R C
RC
O'Donovan
C
C
Hawkes
J
J
Hussein
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D010624:Phenelzine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D010949:Plasma / Q000187:drug effects*; D011569:Psychiatric Status Rating Scales; D011732:Pyridoxal Phosphate / Q000097:blood* / Q000378:metabolism*
D011732:Pyridoxal Phosphate; D010624:Phenelzine