Neonatal lupus erythematosus with cardiac involvement in offspring of mothers with experimental systemic lupus erythematosus.
Neonatal lupus erythematosus (NLE) syndrome is characterized by a transient dermatitis, a variety of systemic and hematological abnormalities, and isolated cases of congenital complete heart block. The latter has been reported to be due to the presence of autoantibodies specific to La (SS-B) and/or Ro (SS-A). As female mice with experimental systemic lupus erythematosus (SLE) induced by immunization with the human monoclonal anti-DNA antibody bearing the 16/6 Id produce variety of autoantibodies including anti-Ro and anti-La antibodies, we looked for NLE related symptoms in the murine model. Offspring of BALB/c mice with SLE possessed high levels of autoantibodies that declined gradually till reduced to normal levels at day 60 after delivery. Electrocardiograms recorded in groups of offspring from mothers with experimental SLE indicated that a high percentage of the offspring had defects in their conductive system including first-, second-, and third-degree heart block, significant bradycardia, and a wide QRS complex. In contrast, a normal pattern was observed in offspring of healthy mothers.
Kalush
F
F
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Rimon
E
E
Keller
A
A
Mozes
E
E
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D001919:Bradycardia / Q000151:congenital*; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000151:congenital*; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000276:immunology; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy
D000974:Antibodies, Antinuclear