[Synthesis of terephthalic acid derivatives and their activity on human promyelocytic leukaemia cells HL-60].
There were 13 derivatives of terephthalic acid were synthesized, in which 9 compounds were not found in literature. The 9 compounds were evaluated for their differentiation-inducing activities on human promyelocytic leukaemia cells HL-60. Compounds N1 and N4 possessed potential activity. Their percentage of differentiating effect was 55% (5 x 10(-6) mol/L), but it was less than that of retinoic acid (79%, 10(-7) mol/L).
Chen
B
B
Xu
P
P
Zeng
Z
Z
D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D010795:Phthalic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D010795:Phthalic Acids; C011363:terephthalic acid