Fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion: a geriatric case report and a review of the literature.
In a frail, elderly, depressed patient, hyponatremia can present a difficult diagnostic and management challenge. We report the case of a severely depressed 83-year-old woman presenting with severe hyponatremia, eventually attributed to a syndrome of inappropriate, antidiuretic hormone (SIADH) secretion induced by fluoxetine. This case is discussed in the context of the multiple potential causes of hyponatremia in an elderly depressed patient, with a focus on fluoxetine-induced SIADH, as reported in 9 other published cases.
Druckenbrod
R
R
Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pennsylvania.
Mulsant
B H
BH
D000368:Aged; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D004565:Electroconvulsive Therapy; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology* / Q000652:urine; D009994:Osmolar Concentration
D005473:Fluoxetine