title: Heart fatty acid binding protein is a novel regulator of cardiac myocyte hypertrophy.
abstract: Heart fatty acid binding protein (H-FABP) is a 15kDa protein that mediates the passage of fatty acids from the plasma membrane to sites of lipid synthesis. We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis and c-jun expression. A high affinity receptor for H-FABP has also been identified. Taken together, these data suggest that H-FABP may participate in the regulation of cardiac myocyte growth and differentiation.
authors: Dept. of Paediatric Cardiology, UMDS, Guys Hospital, London, UK.
authors: P B
authors: PB
authors: Burton
authors: C E
authors: CE
authors: Hogben
authors: C L
authors: CL
authors: Joannou
authors: A G
authors: AG
authors: Clark
authors: J J
authors: JJ
authors: Hsuan
authors: N F
authors: NF
authors: Totty
authors: C
authors: C
authors: Sorensen
authors: R W
authors: RW
authors: Evans
authors: M J
authors: MJ
authors: Tynan
mesh_terms: D000818:Animals; D001665:Binding Sites; D006332:Cardiomegaly / Q000209:etiology* / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D048429:Cell Size / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D007700:Kinetics; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism*; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D011487:Protein Conformation; D051381:Rats
chemical_list: D002352:Carrier Proteins; C490174:Fabp7 protein, rat; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins