Elevated porphyrins following propofol anaesthesia in acute intermittent porphyria.
A patient with acute intermittent porphyria was anaesthetised with propofol for a minor orthopaedic procedure. Postoperative urinary porphyrins were markedly raised compared to pre-operative values, although the patient remained clinically well. Caution should continue to be exercised when propofol is used in patients with acute porphyrias.
Elcock
D
D
Department of Anaesthesia, Lincoln County Hospital.
Norris
A
A
D000328:Adult; D000622:Aminolevulinic Acid / Q000652:urine; D000768:Anesthesia, General; D006801:Humans; D008297:Male; D011162:Porphobilinogen / Q000652:urine; D017118:Porphyria, Acute Intermittent / Q000652:urine*; D011166:Porphyrins / Q000652:urine*; D015742:Propofol / Q000009:adverse effects*
D011166:Porphyrins; D011162:Porphobilinogen; D000622:Aminolevulinic Acid; D015742:Propofol