Renal cell carcinoma developing in the pediatric recipient of an adult cadaveric donor kidney.
Renal cell carcinoma is an uncommon renal tumor in children, comprising between 1.8% and 6.3% of all malignant renal tumors of childhood (whereas renal cell carcinoma is the commonest renal tumor in adults). We describe a 15-year-old girl with chronic renal failure secondary to renal dysplasia and branchio-oto-renal syndrome, who received a cadaveric renal transplant at 8 years of age from a 25-year-old male donor. She developed severe chronic rejection 4 years after the transplant. A transplant nephrectomy was performed because of persistent gross hematuria. Histopathology of this graft showed chronic severe rejection and papillary necrosis. A fortuitous finding was a 1.5-cm renal cell carcinoma at one of the poles. We suggest that tumors which occur more commonly in adults and less commonly in children must be considered in children receiving adult organ transplants.
Agrawal
R
R
Division of Pediatric Nephrology, Loyola University Medical Center, Maywood, Illinois 60153.
Picken
M
M
Kinzler
G J
GJ
Hatch
D
D
Moel
D I
DI
D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002292:Carcinoma, Renal Cell / Q000209:etiology* / Q000473:pathology; D005260:Female; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology* / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009392:Nephrectomy; D014019:Tissue Donors