title: Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720).
abstract: The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization with Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.
authors: Department of Microbiology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
authors: A A
authors: AA
authors: Scalzo
authors: S L
authors: SL
authors: Elliott
authors: J
authors: J
authors: Cox
authors: J
authors: J
authors: Gardner
authors: D J
authors: DJ
authors: Moss
authors: A
authors: A
authors: Suhrbier
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D018146:Muromegalovirus / Q000276:immunology*; D009842:Oligopeptides / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000956:Antigens, Viral; D009842:Oligopeptides; D013745:Tetanus Toxoid; D014765:Viral Vaccines