The novel activation of ABL by fusion to an ets-related gene, TEL.
In human leukemia, activation of the ABL proto-oncogene locus on chromosome 9 most commonly occurs as a result of its fusion to the BCR locus on chromosome 22. The resulting chimeric protein displays an elevated tyrosine kinase activity. We have identified a novel activation of ABL which involves a gene located on chromosome 12, designated TEL. Like BCR, TEL is fused in-frame with ABL and produces a fusion protein with an elevated tyrosine kinase activity when assayed in an immune complex. The amino-terminal sequences of TEL encode a helix-loop-helix motif which may mediate dimerization.
Papadopoulos
P
P
Leukaemia Research Fund Centre, Institute of Cancer Research, London, United Kingdom.
Ridge
S A
SA
Boucher
C A
CA
Stocking
C
C
Wiedemann
L M
LM
D000595:Amino Acid Sequence; D001483:Base Sequence; D002881:Chromosomes, Human, Pair 12; D003001:Cloning, Molecular; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D016313:Genes, abl; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D000090063:Proto-Oncogene Mas; D014157:Transcription Factors / Q000235:genetics*
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D014157:Transcription Factors