Naltrexone, dopamine receptor agonists and antagonists, and food intake in rats: 1. Food deprivation.
Different forms of food intake are reduced by both agonists and antagonists of dopamine D1 and D2 receptors as well as general opioid antagonists. The present study evaluated whether deprivation (24 h)-induced food intake was altered following systemic administration of either the D1 agonist, SKF-38393, the D1 antagonist, SCH-23390, the D2 agonist, quinpirole, or the D2 antagonist, haloperidol, alone or in combination with the general opioid antagonist, naltrexone. Both SKF-38393 (5-10 mg/kg) and SCH-23390 (100-200 micrograms/kg) significantly and dose dependently reduced deprivation-induced intake. Whereas quinpirole (0.5-1 mg/kg) failed to alter deprivation-induced intake, haloperidol increased deprivation-induced intake at low (50 micrograms) doses and decreased intake at higher (100-500 micrograms/kg) doses. Naltrexone (2.5-10 mg/kg) significantly inhibited deprivation-induced intake. When naltrexone was paired with behaviorally ineffective doses of either SCH-23390 (2.5-100 micrograms/kg), quinpirole (0.01-1 mg/kg), or haloperidol (50 micrograms/kg), the degree of reduction of deprivation-induced intake was significantly greater than that produced by naltrexone alone. Pairing naltrexone with SKF-38393 produced reductions of deprivation-induced intake comparable to that of naltrexone alone.
Hobbs
D J
DJ
Department of Psychology, Queens College, CUNY, Flushing 11367.
Koch
J E
JE
Bodnar
R J
RJ
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D004873:Ergolines / Q000494:pharmacology; D005508:Food Deprivation / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009271:Naltrexone / Q000494:pharmacology*; D019257:Quinpirole; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects; D017448:Receptors, Dopamine D2 / Q000187:drug effects
D001552:Benzazepines; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D004873:Ergolines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D009271:Naltrexone; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D006220:Haloperidol