title: Thrombotic thrombocytopenic purpura: a rare late complication of allogeneic bone marrow transplantation.
abstract: Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) usually occurs in a setting of systemic infection or graft-versus-host reaction during the first weeks following transplant. We report a case of fatal TTP that developed eight months after allogeneic bone marrow transplantation (BMT) without any evident association with other transplantation-related complications. Conditioning chemotherapy could have induced the disorder by causing damage to the vascular endothelium. The removal of immunosuppression, including cessation of cyclosporin A (CyA), may have precipitated the disease.
authors: Department of Hematology, OORR, Reggio Calabria, Italy.
authors: G
authors: G
authors: Pucci
authors: M
authors: M
authors: Martino
authors: F
authors: F
authors: Morabito
authors: P
authors: P
authors: Iacopino
authors: W
authors: W
authors: Arcese
authors: A P
authors: AP
authors: Iori
authors: V T
authors: VT
authors: Lombardo
authors: A
authors: A
authors: L'Abbate
authors: M
authors: M
authors: Santostefano
authors: F
authors: F
authors: Nobile
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology*; D014184:Transplantation, Homologous