Oxybutynin administration diminishes the high gastric muscular tone associated with bladder reconstruction.
Oxybutynin has a proved role in correcting uninhibited detrusor contractions in the intact and the bowel augmented bladder. Beneficial responses to oxybutynin have also been noted after gastrocystoplasty. It has been questioned whether this response reflects a selective effect on the bladder segment or whether there is an additional effect on the gastric patch musculature. We report a case of improved function of a previously poorly complaint gastric neobladder caused by oxybutynin, thereby demonstrating a direct action on gastric smooth muscle.
Sheldon
C A
CA
Division of Urology, Children's Hospital Medical Center, University of Cincinnati, Ohio.
Reeves
D
D
Lewis
A G
AG
D005260:Female; D006801:Humans; D007223:Infant; D016014:Linear Models; D008333:Mandelic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D009119:Muscle Contraction / Q000187:drug effects*; D009129:Muscle Tonus / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010276:Parasympatholytics / Q000494:pharmacology / Q000627:therapeutic use*; D013270:Stomach / Q000187:drug effects / Q000502:physiology / Q000637:transplantation*; D001743:Urinary Bladder / Q000601:surgery*
D008333:Mandelic Acids; D010276:Parasympatholytics; C005419:oxybutynin