Relationship of lithium concentrations in the brain measured by lithium-7 magnetic resonance spectroscopy to treatment response in mania.
Lithium concentrations in the brain were measured in 14 manic patients with bipolar disorder (12 with bipolar disorder, manic, and 2 with bipolar disorder, not otherwise specified, by DSM-III-R) by the use of lithium-7 magnetic resonance spectroscopy ([7Li]MRS). The reduction of Petterson Mania Rating Scale 4 weeks after the initiation of lithium treatment was not significantly correlated with concentrations in serum (r = 0.33), but was correlated with concentrations in the brain (r = 0.64; p < 0.05). These results suggest that the treatment response to lithium in manic patients with bipolar disorder is more closely related to the lithium concentration in the brain as measured by [7Li]MRS than to the concentration in serum.
Kato
T
T
Department of Psychiatry, Shiga University of Medical Science, Japan.
Inubushi
T
T
Takahashi
S
S
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D016651:Lithium Carbonate