title: Effect of selected dietary antioxidants on fatty liver-haemorrhagic syndrome in laying hens.
abstract: 1. Single comb White Leghorn hens of an inbred line highly susceptible to fatty liver haemorrhagic syndrome (FLHS) were fed supplemented dietary ascorbic acid (200 mg/kg), alpha-tocopherol (75 mg/kg), or L-cysteine (3 g/kg, and 6 g/kg) for 28 d in order to evaluate the potential therapeutic effect of these compounds against the disease. 2. Supplementation of ascorbic acid, alpha-tocopherol, or a low level of L-cysteine (3 g/kg) did not significantly affect any of the hepatic variables evaluated. Hepatic glutathione was not increased by the supplementation of dietary L-cysteine. 3. L-cysteine supplemented at a level of 6 g/kg decreased hepatic dry matter and fat contents without affecting the hepatic malondialdehyde or the liver haemorrhagic score. 4. Because one of the predisposing factors of FLHS is a high hepatic fat content it was concluded that dietary supplementation of L-cysteine (6 g/kg) may be useful in the prevention of the disease.
authors: Department of Pathology, University of Guelph, Ontario, Canada.
authors: G J
authors: GJ
authors: Diaz
authors: E J
authors: EJ
authors: Squires
authors: R J
authors: RJ
authors: Julian
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology; D002645:Chickens; D003545:Cysteine / Q000008:administration & dosage / Q000494:pharmacology*; D005234:Fatty Liver / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D005527:Food, Fortified; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D006470:Hemorrhage / Q000517:prevention & control / Q000662:veterinary*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010058:Oviposition; D011201:Poultry Diseases; D013577:Syndrome; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D005978:Glutathione; D003545:Cysteine; D001205:Ascorbic Acid