Intravesical oxybutinin chloride in children with intermittent catheterization: sonographic findings.
The sonographic findings in the bladder are presented in four children with myelomeningocele and neurogenic dysfunction of the bladder, who were treated with intermittent self-catheterization and intravesical oxybutinin chloride. All were referred for routine sonography of the urinary tract. Each had infused a crushed tablet of oxybutinin chloride intravesically 30-120 min before the examination. In two children, brightly echogenic, non-shadowing particles were suspended in the bladder urine. In one of these, the particles swirled giving the impression of a "snowstorm"; in the other, most of the particles gradually settled forming an irregular clump on the bladder base. In the remaining two children, the urine appeared diffusely hazy with innumerable tiny particles giving the impression of a fine mist filling the bladder. The sonographic appearance of the urine in the bladder after intravesical instillation of crushed tablets can be dramatic and can simulate pus, blood, fungus, or other debris in the bladder lumen. In the absence of clinical symptoms or hematuria, a history of recent infusion of medication into the bladder should be sought.
Zerin
J M
JM
Department of Radiology, Riley Hospital for Children, Indiana University Medical Center, Indianapolis 46202-2920.
DiPietro
M A
MA
Ritchey
M L
ML
Bloom
D A
DA
D000283:Administration, Intravesical; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D008591:Meningomyelocele / Q000150:complications; D010276:Parasympatholytics / Q000008:administration & dosage* / Q000627:therapeutic use; D013607:Tablets; D014463:Ultrasonography; D001743:Urinary Bladder / Q000000981:diagnostic imaging*; D001750:Urinary Bladder, Neurogenic / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000209:etiology; D014546:Urinary Catheterization
D008333:Mandelic Acids; D010276:Parasympatholytics; D013607:Tablets; C005419:oxybutynin