title: Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma.
abstract: A white patient with human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma for 10 years died 4 months after the onset of spastic myelopathy. Ultrastructurally, the neuropathologic findings consisted of dystrophic neurites (spheroids) filled with neurofilaments or electron-dense bodies, intense astrocytic reaction with abundant formation of corpora amylacea, and multilamellar bodies. Demyelination and spongiform change were absent. Viruslike particles resembling HTLV-I were detected adjacent to brain endothelial cells.
authors: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
authors: P P
authors: PP
authors: Liberski
authors: P
authors: P
authors: Rodgers-Johnson
authors: R
authors: R
authors: Yanagihara
authors: J W
authors: JW
authors: Lee
authors: B S
authors: BS
authors: Kramer
authors: P
authors: P
authors: Piccardo
authors: C A
authors: CA
authors: Mora
authors: C J
authors: CJ
authors: Gibbs
authors: D C
authors: DC
authors: Gajdusek
mesh_terms: D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000473:pathology* / Q000821:virology; D013116:Spinal Cord / Q000648:ultrastructure* / Q000821:virology