title: [Treatment of puerperal endometritis. Evaluation of the efficacy and safety of clindamycin + gentamycin vs. penicillin + chloramphenicol + gentamycin].
abstract: This was a prospective, single-blind, comparative study in patients with diagnosis of puerperal endometritis, carried out at the Loayza Hospital in Lima, Peru. The objective of this study was to evaluate the efficacy and safety of clindamycin and gentamicin in the management of endometritis vs. penicillin, chloramphenicol and gentamicin for 10 days. Sixty-five patients were enrolled and 62 were evaluable for efficacy. Both treatment groups were comparable in the pre-treatment period in terms of age, history of pregnancies, controls by gynecologist, days of disease and fever, clinical symptoms like fever, pelvic pain, pulse, uterine size and in laboratory, in hematocrit and leukocytes count. In the culture of endometrium tissue, 27/32 patients (84.4%) in Group A (penicillin + CAF + gentamicin) and 27/30 patients (90%) in Group B (clindamycin + gentamicin) had positive cultures at baseline; 18 and 22 patients showed anaerobes; 8 and 4 patients showed anaerobes plus aerobes and, one patient in each treatment group showed aerobes only. Peptostreptococcus and Bacteroides fragilis were the most frequently isolated pathogens. Improvement in lochia fetidity was more rapid in Group B, it turned transparent and not fetid since day 3. Complete cure was significantly better in Group B 24/30 (80%) in comparison with Group A 16/32 (50%) (p = 0.02). Partial response was found in 15 patients (43.3%) in Group A and 5 patients (16.6%) in Group B. Only one case was considered as bacteriological failure in Group A and only one patient in Group B was considered as failure and required an additional operation due to residual abscess.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Departamento de Ginecología y Obstetricia Hospital Arzobispo Loayza, Universidad Peruana Cayetano Heredia, Lima, Perú.
authors: C
authors: C
authors: Gutiérrez
authors: C
authors: C
authors: Carrillo
authors: F
authors: F
authors: Escudero
authors: S
authors: S
authors: Caciano
authors: M
authors: M
authors: García Hjarles
mesh_terms: D000328:Adult; D001419:Bacteria / Q000302:isolation & purification; D002701:Chloramphenicol / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004716:Endometritis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D010406:Penicillins / Q000627:therapeutic use; D011446:Prospective Studies; D011644:Puerperal Disorders / Q000188:drug therapy*; D012449:Safety; D016037:Single-Blind Method
chemical_list: D005839:Gentamicins; D010406:Penicillins; D002981:Clindamycin; D002701:Chloramphenicol
vernacular_title: Tratamiento de endometritis puerperal. Evaluación de la eficacia y seguridad de clindamicina + gentamicina vs. penicilina + cloranfenicol + gentamicina.