Production of a murine monoclonal antibody to the low-incidence red cell antigen Wra: characterisation and comparison with human anti-Wra.
The production of a monoclonal antibody which detects the low-incidence red cell antigen Wra is described. The antibody (BGU1-WR) was isolated following immunization of BALB/tk mice with Wr(a+) cells. BGU1-WR is an IgG1 antibody and reacted in a manner similar to human polyclonal anti-Wra with untreated, protease treated and chemically modified Wr(a+) cells.
Ring
S M
SM
MRC Blood Group Unit, University College London, UK.
Green
C A
CA
Swallow
D M
DM
Tippett
P
P
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D015994:Incidence; D007519:Isoantigens / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D007519:Isoantigens