Advances in the biology of gynecologic cancer.
This review discusses recent insights into the roles of the p53 tumor-suppressor gene and growth factors in the development of ovarian cancer and describes the genes implicated in familial ovarian cancer syndromes related to the MSH2 (Lynch II) and BRCA1 (breast and ovarian cancer) genes. Evidence of the monoclonality of ovarian cancer, which contrasts with data supporting the polyclonal origin of primary peritoneal carcinoma, is presented. Finally, the roles of the human papillomavirus and the HIV virus in the etiology of cervical cancer are analyzed in view of the growing importance of this HIV-associated cancer and the poor outcome in these patients.
Gotlieb
W H
WH
Department of Obstetrics and Gynecology, UCLA School of Medicine, Jonsson Comprehensive Cancer Center 90024-1740.
Berek
J S
JS
D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000276:immunology; D027383:Papillomaviridae; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D002578:Uterine Cervical Dysplasia / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000821:virology*
D016159:Tumor Suppressor Protein p53