Ultrastructural modifications in mice spleen after "Imunotim' treatment.
Imunotim, a polypeptidic extract from bovine thymus, induces the appearance of barrier cells in the spleen; these cells form a syncytial network and play an important role in blood cleaning. They are of fibroblastic origin. The cytoplasm of the cells in the network is dense and contains vesicles that seem to be detached from the nucleolemma. The nuclei are of small sizes. Cells (maybe lymphocytes) in different stages of disintegration can be seen in the network.
Mişcalencu
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D
Department of Anatomy, Faculty of Biology, University of Bucharest, Romania.
Mailat
F
F
Ionescu
M D
MD
Popescu
M
M
D000818:Animals; D002417:Cattle; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D010455:Peptides / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects* / Q000648:ultrastructure*; D013949:Thymus Extracts / Q000494:pharmacology*
D010455:Peptides; D013949:Thymus Extracts