[The synaptic proteins of the temporal associative area in the neocortex (field Ep) of cats with normal and decreased cognitive capacities].
Fractions of light and heavy synaptosomes were prepared from associative temporal area of cat brain, which were previously tested behaviorally for ability to solve the generalization, gnostic and abstraction tasks. The synaptic membrane subfractions and synaptoplasma fractions were isolated and the content of the total protein and of the demasked protein sulfhydryl groups (SH groups) was investigated spectrophotometrically. The maximal content of the demasked SH groups was revealed in the upper subfractions (mainly the membranes of cholinergic synapses) and minimal content--in the lower subfractions (mainly noncholinergic synapses). Significantly smaller total protein content in the upper and middle subfractions of light synaptosomes was found, and more demasked SH groups in the membrane-bound proteins of the upper and middle subfractions of light and heavy synaptosomes was found in the cortex area of the "clever" then "silly" cats. Suggestion concerning characteristic for brains of "clever" cats relatively low total quantity of synapses in the area Ep of the cortex and significantly higher proportion of cholinergic ones is discussed.
Zakharova (Orlova)
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Mukhin
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D000818:Animals; D001923:Brain Chemistry; D002415:Cats; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000378:metabolism*; D005260:Female; D008297:Male; D009484:Neuropsychology; D012727:Sex Characteristics; D018709:Statistics, Nonparametric; D013438:Sulfhydryl Compounds / Q000032:analysis / Q000378:metabolism; D016704:Synapsins / Q000032:analysis / Q000378:metabolism*; D013570:Synaptic Membranes / Q000737:chemistry / Q000378:metabolism; D013574:Synaptosomes / Q000737:chemistry / Q000378:metabolism; D013702:Temporal Lobe / Q000737:chemistry / Q000378:metabolism*
D013438:Sulfhydryl Compounds; D016704:Synapsins
Sinapticheskie belki visochnoĭ assotsiativnoĭ zony neokorteksa koshek (pole Ep) s normal'nymi i snizhennymi kognitivnymi sposobnostiami.