title: Effects of zotepine, haloperidol and clozapine on MK-801-induced stereotypy and locomotion in rats.
abstract: In the present study we compared the effects of the atypical neuroleptic zotepine to haloperidol and clozapine on stereotypies and locomotion induced in rats by the N-methyl-D-aspartate (NMDA) antagonist MK-801. Zotepine caused a dose-dependent reduction of MK-801-induced stereotypies and locomotion. Zotepine at a dosis of 2.5 mg/kg body weight showed a similar effect to 0.25 mg/kg haloperidol in reducing stereotypies and locomotion. Clozapine (5.0 mg/kg) reduced significantly locomotion and non-significantly stereotypies. These results add support to the assumption that MK-801-induced behavior provides an adequate animal model to test the potential efficacy of typical and atypical neuroleptics in the treatment of psychoses.
authors: Neurobiology Unit, Central Institute of Mental Health, Mannheim, Federal Republic of Germany.
authors: W F
authors: WF
authors: Gattaz
authors: B
authors: B
authors: Schummer
authors: S
authors: S
authors: Behrens
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D003988:Dibenzothiepins / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D018492:Dopamine Antagonists; D016291:Dizocilpine Maleate; D003024:Clozapine; D006220:Haloperidol; C022172:zotepine