HPV and p53 in urinary bladder carcinoma.
We report a study on human papilloma virus (HPV) and p53 protein in 18 cases of urothelial carcinoma grade 1, 2 and 3. The presence of HPV has been correlated to the p53 protein expression, as this virus, once integrated in the cell nuclei, seems to cause the alteration of some genes expression, involved in the cell-cycle regulation, like p53. One case of urothelial papillary carcinoma grade 2, infiltrating the lamina propria, resulted to be positive for HPV type 31/33/51 and for p53 protein. Our data suggest that HPV type 31/33/51 may have played a role in the pathogenesis of this neoplasia causing an alteration of p53 gene.
Mincione
G P
GP
Instituto di Anatomia e Isologia Patologica, Università di Firenze.
Messerini
L
L
Saltutti
C
C
Di Cello
V
V
Dominici
A
A
Giannelli
E
E
Baroni
G
G
Calzolari
A
A
D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000209:etiology* / Q000378:metabolism / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D001749:Urinary Bladder Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000821:virology
D016159:Tumor Suppressor Protein p53