title: Cyclic amidine analogues of taurine and homotaurine: synthesis and effects on rat skeletal muscle.
abstract: A series of amidinosulfonic acids IIIa-f, analogs of taurine and homotaurine, was synthesized by reacting 2-aminoethane or 3-aminopropane sulfonic acid with lactim ethers Ia-c and then cyclized to sultams IVa-c and Vd-f. The effects of some selected amidinosulfonic acids III on membrane ionic conductances of rat skeletal muscle are described.
authors: Dipartimento Farmaco-Chimico, Università degli Studi, Bari, Italy.
authors: F
authors: F
authors: Campagna
authors: A
authors: A
authors: Carotti
authors: G
authors: G
authors: Casini
authors: F
authors: F
authors: Palluotto
authors: S
authors: S
authors: Pierno
authors: D
authors: D
authors: Tricarico
authors: A
authors: A
authors: De Luca
authors: D
authors: D
authors: Conte-Camerino
mesh_terms: D000578:Amidines / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D013654:Taurine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000578:Amidines; D013451:Sulfonic Acids; D013654:Taurine; C001355:tramiprosate