Photolytic destruction and polymeric resin decontamination of aqueous solutions of pharmaceuticals.
Amoxicillin, ampicillin, bleomycin, carmustine, cephalothin, dacarbazine, lomustine, metronidazole, norethindrone, streptozocin, sulfamethoxazole, and verapamil were completely degraded in solution, without the production of mutagenic residues, by photolysis using a medium-pressure mercury lamp in an all-quartz apparatus. A stream of air was passed through the solution and for amoxicillin, ampicillin, bleomycin, lomustine, metronidazole, and norethindrone it was necessary to add hydrogen peroxide. Dilute aqueous solutions of ampicillin, bleomycin, carmustine, cephalothin, lomustine, norethindrone, streptozocin, trimethoprim, and verapamil can be decontaminated using polymeric Amberlite resins.
Lunn
G
G
Program Resources, Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, MD 21702-1201.
Rhodes
S W
SW
Sansone
E B
EB
Schmuff
N R
NR
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006256:Hazardous Waste; D006861:Hydrogen Peroxide; D066298:In Vitro Techniques; D017744:Medical Waste Disposal; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity; D004364:Pharmaceutical Preparations / Q000528:radiation effects*; D010782:Photolysis; D051381:Rats; D012116:Resins, Plant / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays; D014867:Water
D006256:Hazardous Waste; D017744:Medical Waste Disposal; D009153:Mutagens; D004364:Pharmaceutical Preparations; D012116:Resins, Plant; D012996:Solutions; D014867:Water; D006861:Hydrogen Peroxide