title: Interstitial laser photocoagulation as a treatment for breast cancer.
abstract: This preliminary report describes the use of interstitial laser photocoagulation to manage small breast cancers. Forty-four patients were treated with a diode laser of 805 nm under local anaesthesia in the interval between diagnosis and surgery. Ultrasonography was used in 42 patients and computed tomography (CT) in two to place the fibre in the tumour and monitor laser effects. Laser-induced necrosis within the resected tumour varied from 0 to 25 mm in diameter. The presence of charring in the tumour around the fibre tip after treatment was associated with significantly larger diameters of necrosis than when charring did not occur (median 13 versus 6 mm, P = 0.002). Precharring the fibre resulted in a more predictable diameter of necrosis (median 14 mm). Ultrasonography was inaccurate in assessing laser damage; dynamic CT and magnetic resonance imaging may be of more use. Interstitial laser photocoagulation is simple and safe, and can produce necrosis of a reasonably predictable extent.
authors: National Medical Laser Centre, University College London Medical School, UK.
authors: S A
authors: SA
authors: Harries
authors: Z
authors: Z
authors: Amin
authors: M E
authors: ME
authors: Smith
authors: W R
authors: WR
authors: Lees
authors: J
authors: J
authors: Cooke
authors: M G
authors: MG
authors: Cook
authors: J H
authors: JH
authors: Scurr
authors: M W
authors: MW
authors: Kissin
authors: S G
authors: SG
authors: Bown
mesh_terms: D001940:Breast / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D017075:Laser Coagulation / Q000379:methods*; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D016217:Ultrasonography, Mammary