Effect of sodium thiosulfate on the photolysis of phenobarbital: evidence of complex formation.
Photodegradation of phenobarbital in aqueous solutions exposed to short-wave ultraviolet light was studied in presence and in absence of sodium thiosulfate. The degradation process appeared to follow first-order kinetics and was found to be dependent on pH, buffer system and sodium thiosulfate concentration. Ionic strength did not have any appreciable effect. The rate of photodegradation was found to be inversely proportional to phenobarbital concentration, especially below 8 x 10(-4) M. Solutions of phenobarbital containing alcohol, propylene glycol and benzyl alcohol as cosolvents showed markedly improved stability under UV irradiation in absence of sodium thiosulfate. Complex formation between the thiosulfate anion and phenobarbital appeared to be primarily responsible for the photostabilization of the drug. The equilibrium constant for this complex was calculated to be 36.23 M-1.
Asker
A F
AF
College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee.
Islam
M S
MS
D000975:Antioxidants / Q000494:pharmacology*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D010634:Phenobarbital / Q000737:chemistry* / Q000528:radiation effects; D010782:Photolysis / Q000187:drug effects*; D013696:Temperature; D013885:Thiosulfates / Q000494:pharmacology*; D014466:Ultraviolet Rays
D000975:Antioxidants; D013885:Thiosulfates; C017717:sodium thiosulfate; D010634:Phenobarbital