Human apo A-I in transgenic mice is more efficient in activating lecithin:cholesterol acyltransferase than mouse apo A-I.
This study shows that, in control and transgenic mice, there is a parallel increase in LCAT activity and plasma apo A-I concentrations during postnatal development. We also demonstrate that human apo A-I is a much more efficient activator (1.6-fold) of mouse LCAT activity than mouse apo A-I. We propose that the differences in amino acid sequence between human and mouse apo A-I may account for the higher LCAT activity with human apo A-I.
Golder-Novoselsky
E
E
Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Nichols
A V
AV
Rubin
E M
EM
Forte
T M
TM
D000818:Animals; D016632:Apolipoprotein A-I / Q000494:pharmacology*; D004789:Enzyme Activation; D006801:Humans; D007700:Kinetics; D051379:Mice; D008822:Mice, Transgenic; D013045:Species Specificity; D002785:Sterol O-Acyltransferase / Q000378:metabolism*
D016632:Apolipoprotein A-I; D002785:Sterol O-Acyltransferase