title: High prevalence of Helicobacter pylori metronidazole resistance in migrants to east London: relation with previous nitroimidazole exposure and gastroduodenal disease.
abstract: A high prevalence of metronidazole resistance in Helicobacter pylori is reported in developing countries. This study examined whether migrants referred for diagnostic gastroscopy at a United Kingdom centre (n = 54), had a higher prevalence of metronidazole resistance than subjects born in the United Kingdom attending endoscopy (n = 46). Records of nitroimidazole treatment prescribed in the United Kingdom was obtained in 83 patients to find out if there was an association between H pylori metronidazole resistance and previous ingestion of either metronidazole or tinidazole. The prevalence of metronidazole resistant isolates varied according to country of birth: Bangladesh (90%, 27 of 30), other countries (67%, 16 of 24), and United Kingdom (37%, 17 of 46) (p < 0.001). Among those born in the United Kingdom, women were more likely to harbour resistant H pylori than men (54% v 18% respectively, p = 0.01) and more likely to have a history of previous nitroimidazole ingestion (41% v 11% respectively, p = 0.02). Patients previously exposed to either metronidazole or tinidazole were more likely to harbour resistant strains (84% (27 of 32) v 41% (21 or 51), p < 0.0001). The distribution of gastroduodenal disease, assessed endoscopically, was not affected by metronidazole resistance status.
authors: Department of Epidemiology and Medical Statistics, London Hospital Medical College, QMW.
authors: N
authors: N
authors: Banatvala
authors: G R
authors: GR
authors: Davies
authors: Y
authors: Y
authors: Abdi
authors: L
authors: L
authors: Clements
authors: D S
authors: DS
authors: Rampton
authors: J M
authors: JM
authors: Hardie
authors: R A
authors: RA
authors: Feldman
mesh_terms: D000328:Adult; D003906:Developing Countries; D004352:Drug Resistance, Microbial; D004378:Duodenal Diseases / Q000208:ethnology / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000208:ethnology*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008131:London / Q000453:epidemiology; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008875:Middle Aged; D009593:Nitroimidazoles / Q000008:administration & dosage*; D011446:Prospective Studies; D012737:Sex Factors; D013272:Stomach Diseases / Q000208:ethnology / Q000382:microbiology
chemical_list: D009593:Nitroimidazoles; D008795:Metronidazole