Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma.
We investigated the mechanism of polyclonal B cell differentiation in mantle cell lymphoma (MCL) using peripheral blood mononuclear cells (PBMC) from a patient with MCL in leukemic stage presenting polyclonal hypergammaglobulinemia. Patient T cells not only responded to autologous non-T cells but induced polyclonal production of IgG in vitro. Flow cytometric analysis of PBMC showed the increased conversion of CD4+ T cells from the naive to the memory state. We propose the possible mechanism that autoreactive T cells may be involved in polyclonal B cell differentiation in this monoclonal B cell disorder.
Hirokawa
M
M
Department of Internal Medicine, Akita University School of Medicine, Japan.
Lee
M
M
Kitabayashi
A
A
Chubachi
A
A
Itoh
T
T
Miura
I
I
Saitoh
M
M
Miura
A B
AB
D001402:B-Lymphocytes / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000502:physiology*