title: Factors influencing between-laboratory variability of C-reactive protein results as evidenced by the Belgian External Quality Assessment(EQA) Scheme.
abstract: Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using homogeneous systems with several calibration points generally achieved better performance. Working temperatures influenced the results to a lesser extent. The present study stresses the importance for EQA organizers to collect more detailed information about CRP analytical methods used by the participants. It also suggests that manufacturers should be more involved in the management of quality, in particular by striving for standardization of the material (kit and calibrator) they produce for CRP assay.
authors: Institut d'Hygiène et d'Epidémiologie, Service de Biologie Clinique, Brussels, Belgium.
authors: N
authors: N
authors: Devleeschouwer
authors: J C
authors: JC
authors: Libeer
authors: J P
authors: JP
authors: Chapelle
authors: C L
authors: CL
authors: Struway
authors: C
authors: C
authors: Gyssels
authors: A
authors: A
authors: L'Hoir
authors: A
authors: A
authors: Albert
mesh_terms: D001530:Belgium; D002097:C-Reactive Protein / Q000032:analysis*; D002138:Calibration; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D005779:Immunodiffusion; D007753:Laboratories / Q000592:standards*; D009391:Nephelometry and Turbidimetry; D011786:Quality Control; D015203:Reproducibility of Results
chemical_list: D002097:C-Reactive Protein