title: Membranoproliferative glomerulonephritis associated with hepatitis C virus infection responsive to interferon-alpha.
abstract: A 42-year-old man with hepatitis C virus infection, cryoglobulinemia, hypocomplementemia, and nephrotic syndrome is reported. The kidney biopsy showed membranoproliferative glomerulonephritis. The patient was treated with interferon-alpha for 2 months. After the treatment, serum hepatitis C virus RNA became negative and nephrotic syndrome remitted. Repeat biopsy of the kidney revealed an improvement in renal histology. This case confirms an association between hepatitis C virus infection and membranoproliferative glomerulonephritis and the usefulness of interferon-alpha for treatment.
authors: Second Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
authors: H
authors: H
authors: Yamabe
authors: R J
authors: RJ
authors: Johnson
authors: D R
authors: DR
authors: Gretch
authors: H
authors: H
authors: Osawa
authors: H
authors: H
authors: Inuma
authors: T
authors: T
authors: Sasaki
authors: M
authors: M
authors: Kaizuka
authors: N
authors: N
authors: Tamura
authors: S
authors: S
authors: Tsunoda
authors: Y
authors: Y
authors: Fujita
mesh_terms: D000328:Adult; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology / Q000821:virology*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male
chemical_list: D016898:Interferon-alpha