[The host-opportunistic protozoa system. The dissemination of Leishmania infantum infection in naturally susceptible laboratory animals subjected to drug-induced immunosuppression].
The possibility to awake the disseminated infection of Leishmania infantum in golden hamsters Mesocricetus auratus, hispid cotton rats Sigmodon hispidus, soft furred rats Mastomys natalensis by means of different immunodepressants has been examined. On the background of the immunosuppression caused by corticosteroids of short time activity (metipred, hydrocortison) leishmaniae were revealed both in the target organs (spleen, liver, marrow) and in lungs, in cases of using the corticosteroid of prolonged activity (tricort-40) leishmaniae were observed also in lungs, kidneys, testis.
Kovalenko
F P
FP
Lysenko
A Ia
AIa
Lavdovskaia
M V
MV
D000818:Animals; D006224:Cricetinae; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D006790:Host-Parasite Interactions; D006854:Hydrocortisone / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects*; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000209:etiology* / Q000276:immunology / Q000469:parasitology; D008297:Male; D008647:Mesocricetus; D008775:Methylprednisolone / Q000494:pharmacology; D051381:Rats; D016205:Sigmodontinae; D014222:Triamcinolone Acetonide / Q000494:pharmacology
D003692:Delayed-Action Preparations; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone; D008775:Methylprednisolone
Sistema "khoziain--uslovno-patogennye prosteĭshie". Disseminatsiia infektsii Leishmania infantum u estestvenno vospriimchivykh laboratornykh zhivotnykh, podvergnutykh medikamentoznoĭ immunosupressii.