Anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis in rats.
The anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis was investigated. Local application of this manganese superoxide dismutase given every 2 days not only significantly reduced foot swelling but also retarded radiological bone destruction in adjuvant arthritis. Copper zinc superoxide dismutase had little effect on foot swelling.
Shingu
M
M
Department of Clinical Immunology, Kyushu University, Beppu, Japan.
Takahashi
S
S
Ito
M
M
Hamamatu
N
N
Suenaga
Y
Y
Ichibangase
Y
Y
Nobunaga
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins; D013482:Superoxide Dismutase / Q000008:administration & dosage*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011994:Recombinant Proteins; D013482:Superoxide Dismutase