Influence of elevated body temperature on circulating immunoglobulin-secreting cells.
This work was designed to investigate the effect of in vivo hyperthermia in man on circulating immunoglobulin-secreting cells. Eight healthy male volunteers were immersed into a hot waterbath (WI) (water temperature 39.5 degrees C) for 2 h, whereby their body temperature rose to 39.5 degrees C. On another occasion they served as their own controls, being immersed into thermoneutral water (water temperature 34.5 degrees C) for 2 h. Blood samples were drawn before immersion, at body temperatures of 38, 39 and 39.5 degrees C, as well as 2 h after WI when their body temperatures were normalized. In the control experiments, blood samples were drawn at identical time points. A significant increase in the number of IgM-secreting cells per fixed number of blood mononuclear cells (BMNC) occurred 2 h after WI, whereas the number of IgA-secreting cells per fixed number of BMNC did not change. When the possible redistribution of BMNC was taken into account, the concentrations of IgM- and IgA-secreting cells (per ml blood) increased non-significantly during WI.
Kappel
M
M
Department of Infectious Diseases, Rigshospitalet, National University Hospital, Copenhagen, Denmark.
Barington
T
T
Gyhrs
A
A
Pedersen
B K
BK
D000328:Adult; D000921:Antibody-Producing Cells / Q000276:immunology*; D001831:Body Temperature / Q000276:immunology; D005334:Fever / Q000097:blood / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D018655:Lymphocyte Count; D008297:Male
D007070:Immunoglobulin A; D007075:Immunoglobulin M