[The correlation between occurrence of intracranial germ cell tumors and p53 tumor suppressor gene mutations].
Using PCR-SSCP molecular biological techniques and sequencing analysis, an investigation on intracranial germ cell tumors for a correlation between the p53 tumor suppressor gene mutations and the occurrence of these tumors was performed. The results were as follows: 1. The p53 gene mutations were closely related with the development of intracranial germ cell tumors; 2. Among the germ cell tumors, different types of tumors had different p53 tumor gene mutations.
Feng
X L
XL
Department of Pathology, Capital Institute of Pediatrics, Beijing.
Kumanishi
T
T
D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D001932:Brain Neoplasms / Q000235:genetics*; D018236:Carcinoma, Embryonal / Q000235:genetics; D002648:Child; D005260:Female; D016158:Genes, p53; D018237:Germinoma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction