[Mechanism of disorders of the cerebral blood supply during stress in spontaneously hypertensive rats].
The immobilization- and sound stimulus-induced changes in cerebral circulation were studied in spontaneously hypertensive rats. It was found that there was a stress-induced increase in the levels of epinephrine and norepinephrine in brain tissue, which was associated with lower levels of vasoactive prostaglandins E and F2 and with their imbalance with vasodilator prostaglandins E being prevalent. The change in the cerebral ratio of biologically active substances results in cerebral blood flow autoregulation failure and development of large cerebral hemorrhages.
Romanova
T P
TP
Karpel'
G G
GG
Brill'
G E
GE
Markov
Kh M
KhM
D000818:Animals; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*
K mekhanizmu narusheniia krovosnabzheniia golovnogo mozga pri stresse u spontanno gipertenzivnykh krys.