title: Subcortical aphasia: distinct profiles following left putaminal hemorrhage.
abstract: Numerous reports of aphasia after subcortical lesions have produced incomplete agreement about basic clinico-anatomic correlations. Some disagreement has arisen from methodologic differences. To control for some of the common differences, we analyzed 13 patients with left putaminal hemorrhage controlled for location--subcortical but not thalamic, and for time postonset--studied in both acute and postacute epochs. There was no apparent correlation between lesion site and acute language profiles. During the postacute epoch, there were several distinct correlations between lesion site (postacute decreased CT density) and specific aphasia dimensions--nonfluency, impaired comprehension, and perhaps impaired repetition. Our correlations were compatible with comparably controlled cases in the literature. A corollary result of this study is that patients fluent during the early epoch are likely to have a better outcome, and those initially nonfluent have a poor prognosis for language recovery.
authors: Department of Neurology, University of Pennsylvania, Philadelphia 19104-4283.
authors: M
authors: M
authors: D'Esposito
authors: M P
authors: MP
authors: Alexander
mesh_terms: D000368:Aged; D001037:Aphasia / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D002543:Cerebral Hemorrhage / Q000150:complications / Q000503:physiopathology*; D006408:Hematoma, Subdural; D006801:Humans; D007802:Language; D008875:Middle Aged; D011379:Prognosis; D011699:Putamen / Q000000981:diagnostic imaging*; D013060:Speech; D014057:Tomography, X-Ray Computed