Changes in etilefrine-induced CNS effects when associated with theophylline.
A diverse set of techniques (curiosity, chimney test, changes in barbiturate-induced sleep time, spontaneous motor activity, swimming ability, body temperature) was used to study theophylline (T)-induced changes in CNS etilefrine (E). T antagonized the depressive effects produced by high doses of E. Nevertheless, the LD50 of E was not modified when both drugs were administered simultaneously.
Pinel
M P
MP
Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, Spain.
Ocete
M A
MA
Miró
M
M
Jiménez
J
J
Risco
S
S
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004347:Drug Interactions; D005039:Etilefrine / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013806:Theophylline / Q000494:pharmacology*
D013806:Theophylline; D005039:Etilefrine