Recurrence of immunoglobulin A-kappa crystalline deposition disease after kidney transplantation.
Cases of immunoglobulin A heavy chain and kappa light chain deposition disease are rare and their clinical presentations vary. We report one patient with histopathologic and clinical findings of a microangiopathic glomerulonephritis due to immunoglobulin A-kappa deposition. Ultrastructural studies revealed highly ordered deposits in the capillary lumen, mesangium, and basement membrane. The disease recurred at 2.5 years after a cadaveric kidney transplantation. Pulse steroid therapy was repeatedly effective in retarding further progression of renal deterioration in this patient.
Lin
J J
JJ
Department of Pediatrics, State University of New York at Stony Brook 11794.
Miller
F
F
Waltzer
W
W
Kaskel
F J
FJ
Arbeit
L
L
D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006362:Heavy Chain Disease / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D008875:Middle Aged; D012008:Recurrence
D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains