title: [Sigmoid diverticulitis in immunosuppressive drug therapy].
abstract: In a retrospective study we evaluated the data of 92 patients (41 women, 51 men, age median: 63 years) with diverticulitis of the sigma who were treated surgically in our clinic from January 1986 till December 1992. Twelve patients (13%) suffered from suppression of the immune system due to a corticoid therapy (n = 3), chemotherapy (n = 1), combination of corticoid therapy and chemotherapy (n = 1), combination of chemotherapy and azathioprine, leucopenia due to carbimazole therapy as a side effect (n = 1) and immunosuppression with prednisone, azathioprine and cyclosporine after renal and heart transplantations (n = 5). The therapy was Hartmann's procedure in 5 patients, drainage and loop colostomy in one patient, sigma resection with primary anastomosis without a protective enterostomy in 5 patients and with a loop ileostomy in one patient. One patient died in the early postoperative course. Sigma diverticulitis in immunosuppressed patients is a well-known problem especially in large clinics with organ transplantation units. In contrast to reports from up to the eighties we found no significant difference in the postoperative morbidity and mortality after surgical treatment of acute sigma diverticulitis in immunosuppressed patients compared to non immunosuppressed patients.
authors: Klinik für Allgemein- und Unfallchirurgie, Heinrich-Heine-Universität Düsseldorf.
authors: R
authors: R
authors: Hesterberg
authors: F
authors: F
authors: Müller
authors: W U
authors: WU
authors: Schmidt
authors: G
authors: G
authors: Möslein
authors: B
authors: B
authors: Lammers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003125:Colostomy; D004239:Diverticulitis, Colonic / Q000139:chemically induced / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000601:surgery*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012810:Sigmoid Diseases / Q000139:chemically induced / Q000601:surgery*
chemical_list: D007166:Immunosuppressive Agents
vernacular_title: Sigmadiverticulitis unter medikamentöser Immunsuppression.