Commissurotomies in children.
Although corpus callosotomy has been used since 1940 to treat severe, medically intractable seizure disorders, controversy remains as to when, or even if, the surgery should be performed. Unlike other types of surgical therapy of epilepsy where the epileptic focus is identified and removed, corpus callosotomy is used to interrupt the propagation of epileptic discharges. The procedure is primarily used in patients with secondarily generalized seizures in whom focal resections are not possible. Long-term follow-up studies of post-callosotomy patients are few and flawed by lack of accurate seizure counts and quality-of-life measures. Although it remains difficult to predict those patients who will benefit from the surgery, it appears that patients with "drop" attacks benefit the most from the procedure.
Carmant
L
L
Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA 02115.
Holmes
G L
GL
D000818:Animals; D001931:Brain Mapping; D002648:Child; D003337:Corpus Callosum / Q000503:physiopathology / Q000601:surgery*; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004827:Epilepsy / Q000145:classification / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000503:physiopathology; D012008:Recurrence