title: Changes in etilefrine-induced CNS effects when associated with theophylline.
abstract: A diverse set of techniques (curiosity, chimney test, changes in barbiturate-induced sleep time, spontaneous motor activity, swimming ability, body temperature) was used to study theophylline (T)-induced changes in CNS etilefrine (E). T antagonized the depressive effects produced by high doses of E. Nevertheless, the LD50 of E was not modified when both drugs were administered simultaneously.
authors: Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, Spain.
authors: M P
authors: MP
authors: Pinel
authors: M A
authors: MA
authors: Ocete
authors: M
authors: M
authors: Miró
authors: J
authors: J
authors: Jiménez
authors: S
authors: S
authors: Risco
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004347:Drug Interactions; D005039:Etilefrine / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013806:Theophylline / Q000494:pharmacology*
chemical_list: D013806:Theophylline; D005039:Etilefrine