title: Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease.
abstract: Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD.
authors: Regional Center of Neurogenetics, CHR of Reims, France.
authors: G
authors: G
authors: Lucotte
authors: S
authors: S
authors: Visvikis
authors: B
authors: B
authors: Leininger-Müler
authors: F
authors: F
authors: David
authors: S
authors: S
authors: Berriche
authors: S
authors: S
authors: Réveilleau
authors: R
authors: R
authors: Couderc
authors: M C
authors: MC
authors: Babron
authors: D
authors: D
authors: Aguillon
authors: G
authors: G
authors: Siest
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D013997:Time Factors
chemical_list: D001057:Apolipoproteins E; D004247:DNA