[An echocardiographic study of the left ventricular functional indices in pediatric patients on hemodialysis and in treatment with recombinant human erythropoietin (r-HuEPO)].
Recombinant human erythropoietin (r-HuEPO) is efficient in the treatment of anaemia in chronic renal failure on hemodialysis. We investigated the changes in cardiac function under r-HuEPO therapy using echocardiography. Seven patients with severe renal anaemia (Ht 19%) were treated with 50 U/kg r-HuEPO EV three times/week. Echocardiographic studies were performed in the anemic state and when hematocrit values were stable at levels (Ht 30%). Left ventricular function as showed by fractional shortening (D%) improved, the thickness of the interventricular septum and left ventricular hypertrophy were reduced. Our data indicate that the correction of renal anaemia by r-HuEPO can improve myocardial function in patients on maintenance hemodialysis.
Seracini
D
D
Divisione di Nefrologia e Dialisi, Università di Firenze, Italia.
Pollini
I
I
Lavoratti
G C
GC
Pela
I
I
Materassi
M
M
Danti
D
D
De Simone
L
L
Favilli
S
S
Manetti
A
A
D000740:Anemia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D002648:Child; D004341:Drug Evaluation; D004452:Echocardiography; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects; D016277:Ventricular Function, Left / Q000187:drug effects
D011994:Recombinant Proteins; D004921:Erythropoietin
Studio ecocardiografico degli indici di funzione ventricolare sinistra in pazienti pediatrici emodializzati e in trattamento con eritropoietina umana ricombinante (r-HuEPO).