title: [Indolent mastocytosis and bronchial hyperreactivity. A case report].
abstract: Mastocytosis (MS) may be exclusively cutaneous or, more rarely, systemic. MS may be indolent (benign), aggressive, leukaemic or associated with a myeloproliferative disorder. The clinical expression of MS may be secondary to the direct consequences of the development of mastocytes in tissue or correspond to the paroxysmal features related to the liberation of vasoactive and spasmogenic mediators by activated mastocytes. Dyspnoeic episodes are classical but the physiopathological mechanism is poorly documented. True asthma or bronchopulmonary mastocytosis seems rare. The authors report evidence of non-specific bronchial hyper-reactivity (HRB) to Carbachol in a patient effected with benign cutaneous mastocytosis with secondary elevation of the total serum IGE. Factors determining the HIB are discussed and appear primarily linked to the mastocytosis.
authors: Service de Pneumologie, Hôpital de la Croix-Rousse, CHU, Lyon.
authors: J Y
authors: JY
authors: Bayle
authors: H
authors: H
authors: Arnouk
authors: D
authors: D
authors: de Perthuis
authors: B
authors: B
authors: Chouvet
authors: M
authors: M
authors: Germain-Pastene
authors: G
authors: G
authors: Cozon
authors: F
authors: F
authors: Béjui-Thivollet
authors: M
authors: M
authors: Pérol
authors: C
authors: C
authors: Sanson
authors: J C
authors: JC
authors: Guérin
mesh_terms: D000328:Adult; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000209:etiology*; D002217:Carbachol / Q000009:adverse effects*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008415:Mastocytosis / Q000097:blood / Q000145:classification / Q000150:complications* / Q000473:pathology
chemical_list: D007073:Immunoglobulin E; D002217:Carbachol
vernacular_title: Mastocytose indolente et hyperréactivité bronchique. A propos d'une observation.