Temporal distribution of endogenous retinoids in the embryonic mouse mandible.
Retinoids play an important part in embryonic pattern formation. They are necessary for normal differentiation of odontogenic tissues and, in excess, disrupt the pattern of tooth formation. Excess retinoids produce supernumerary buds of the dental lamina in the diastema region of the mouse embryonic mandible where teeth do not normally form. This effect is coincident with an increase in epithelial proliferation and an alteration in epidermal growth factor mRNA expression (a gene product necessary for tooth formation). It was found by high-performance liquid chromatography that endogenous retinoids are present in the developing murine mandible and that concentrations of some retinoids reach a peak at the time of the initiation of odontogenesis (dental lamina formation).
Beeman
C S
CS
Department of Oral Health Practice, College of Dentistry, University of Kentucky, Lexington.
Kronmiller
J E
JE
D000818:Animals; D002454:Cell Differentiation; D002851:Chromatography, High Pressure Liquid; D004815:Epidermal Growth Factor / Q000235:genetics / Q000378:metabolism; D004848:Epithelium / Q000196:embryology; D015870:Gene Expression; D005865:Gestational Age; D015474:Isotretinoin / Q000032:analysis; D008334:Mandible / Q000737:chemistry / Q000196:embryology*; D051379:Mice; D009805:Odontogenesis / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012176:Retinoids / Q000032:analysis*; D013997:Time Factors; D014059:Tongue / Q000737:chemistry / Q000196:embryology; D014083:Tooth Germ / Q000196:embryology; D014096:Tooth, Supernumerary / Q000196:embryology; D014212:Tretinoin / Q000032:analysis; D014801:Vitamin A / Q000032:analysis
D012333:RNA, Messenger; D012176:Retinoids; D014801:Vitamin A; D014212:Tretinoin; D004815:Epidermal Growth Factor; D015474:Isotretinoin