Low cholesterol and impaired cardiac function following heart transplantation.
1. During follow-up of 59 cardiac transplant recipients over 2 or more years, a small group of subjects was observed who displayed an unpredictable, relatively marked, reduction in plasma cholesterol. 2. A significant proportion of these subjects were subsequently observed as having experienced a marked decline in left ventricular function at the time of routine radionuclide ventriculography. 3. While the mechanism for this fall in cholesterol is unclear, the observation of such an unexpected reduction in total cholesterol, late after heart transplantation should be considered significant and prompt further investigation including an assessment of allograft function.
Kaye
D M
DM
Alfred and Baker Medical Unit, Baker Medical Research Institute, Melbourne, Victoria, Australia.
Johnston
L
L
Dart
A M
AM
D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000503:physiopathology*; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D015635:Radionuclide Ventriculography; D012189:Retrospective Studies; D013318:Stroke Volume; D014280:Triglycerides / Q000097:blood; D016277:Ventricular Function, Left / Q000502:physiology
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol