Identification of the TCL1 gene involved in T-cell malignancies.
The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas. The chromosome 14 region translocated or rearranged involves approximately 350 kb of DNA at chromosome band 14q32.1. Within this region we have identified a gene coding for a 1.3-kb transcript, expressed only in restricted subsets of cells within the lymphoid lineage and expressed at high levels in leukemic cells carrying a t(14;14)(q11;q32) chromosome translocation or a inv(14)(q11;q32) chromosome inversion. The cognate cDNA sequence reveals an open reading frame of 342 nt encoding a protein of 14 kDa. The TCL1 gene sequence, which, to our knowledge, shows no sequence homology with other human genes, is preferentially expressed early in T- and B-lymphocyte differentiation.
Virgilio
L
L
Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107.
Narducci
M G
MG
Isobe
M
M
Billips
L G
LG
Cooper
M D
MD
Croce
C M
CM
Russo
G
G
D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000502:physiology*; D001483:Base Sequence; D001853:Bone Marrow / Q000502:physiology; D002454:Cell Differentiation; D002883:Chromosomes, Human, Pair 14; D003001:Cloning, Molecular; D017931:DNA Primers / Q000737:chemistry; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005796:Genes; D006801:Humans; D015458:Leukemia, T-Cell / Q000235:genetics; D008969:Molecular Sequence Data; D009857:Oncogenes; D011518:Proto-Oncogene Proteins; D015183:Restriction Mapping; D013601:T-Lymphocytes / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic
D017931:DNA Primers; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C090851:TCL1A protein, human; D014157:Transcription Factors