title: Pulmonary fibrosis correlates with outcome in adult respiratory distress syndrome. A study in mechanically ventilated patients.
abstract: OBJECTIVE
  The present study was carried out to evaluate the prognostic value of pulmonary fibrosis diagnosed on the basis of pulmonary samples obtained by fiberscopic transbronchial lung biopsy (TBLB) in patients treated for severe established adult respiratory distress syndrome (ARDS).
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Intensive Care Unit of a University Hospital.
  
  
  METHODS
  Consecutive patients with a diagnosis of established ARDS.
  
  
  METHODS
  Samples of pulmonary tissue (3 to 6 in each patient) were obtained by fiberoptic TBLB. Severity of pulmonary fibrosis was assessed based on pathologic changes. Hematoxylin and eosin and Masson's trichrome stains were performed on each tissue sample.
  
  
  RESULTS
  Twenty-two lung specimens were obtained from 25 consecutive patients with ARDS of various origin (postsurgical complications, 7 patients; multiple trauma, 8 patients; medical problems, 7 patients). Transbronchial lung biopsy was complicated by small or moderate hemorrhage in three patients. No case of pneumothorax was identified. Pathologic findings showed that 14 patients (64%) had pulmonary fibrosis, either mild (9 patients) or moderate to severe fibrosis (5 patients). In the patients with pulmonary fibrosis, mortality rate was 57% (8 out of 14 patients), which was significantly different (p < 0.02) from the 0% mortality rate observed in patients without pulmonary fibrosis. Severity of pulmonary fibrosis (mild vs moderate and severe) did not influence outcome. With the exception of pathologic findings, characteristics of patients with and without pulmonary fibrosis (PaO2, PaCO2, the ratio of PaO2 to fraction of inspired oxygen, and positive end-expiratory pressure) were not different.
  
  
  CONCLUSIONS
  In the study patients, pulmonary fibrosis diagnosed on the basis of TBLB was closely related to fatality in established ARDS.
authors: Département d' Anesthésie-Réanimation, Hospital Sainte-Marguerite, Marseille, France.
authors: C
authors: C
authors: Martin
authors: L
authors: L
authors: Papazian
authors: M J
authors: MJ
authors: Payan
authors: P
authors: P
authors: Saux
authors: F
authors: F
authors: Gouin
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000473:pathology; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000150:complications* / Q000473:pathology / Q000628:therapy