title: A linear relationship between ATP degradation and fatigue during high-intensity dynamic exercise in rat skeletal muscle.
abstract: The relationship between changes in work output (fatigue) and metabolite concentrations was measured in rat skeletal muscle during the course of dynamic exercise (10 s). After 4 s, work output decreased rapidly to approximately 30% at 8 s. In contrast to the changes in phosphocreatine and lactate, the change in ATP concentration paralleled the reduction in work output. A strong linear relationship (r = 0.95) was found between the relative decrease in ATP and the extent of fatigue. Possible mechanisms underlying this relationship are discussed.
authors: Faculty of Human Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands.
authors: A
authors: A
authors: de Haan
authors: J C
authors: JC
authors: Koudijs
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009119:Muscle Contraction; D018763:Muscle Fatigue / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007773:Lactates; D010725:Phosphocreatine; D019344:Lactic Acid; D000255:Adenosine Triphosphate