Well differentiated astrocytoma occurring nine years after radiation therapy for medulloblastoma.
Conventional treatment for medulloblastoma includes surgical resection followed by craniospinal irradiation, with the potential risk of subsequent radiotherapy-induced secondary neoplasms. We report a 23-year-old woman previously irradiated nine years earlier for a cerebellar medulloblastoma who developed a new enhancing lesion in the primary radiation field four weeks following completion of high dose chemotherapy with bone marrow transplantation for recurrent disease. Resection of this lesion revealed a low grade glioma with no evidence of recurrent medulloblastoma.
Osumi
A K
AK
Department of Radiology, Duke University Medical Center, Durham, NC 27710.
Mclendon
R E
RE
Tien
R D
RD
Friedman
H S
HS
Graham
M
M
Hockenberger
B
B
Halperin
E C
EC
Oakes
W J
WJ
D000328:Adult; D001254:Astrocytoma / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D002531:Cerebellum / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008527:Medulloblastoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D018714:Radiotherapy, Adjuvant