Biomimetic pulmonary surfactants.
Considerable progress has been made in the development of defined mixtures of proteins or peptides with phospholipids which mimic the activity of natural pulmonary surfactants. Several of these biomimetic surfactants are active in animal models and clinical syndromes of surfactant deficiency. This review summarizes the structure and composition of natural surfactants and the development of defined mixtures of peptides and lipids that may be useful in the treatment of respiratory distress.
McLean
L R
LR
Marion Merrell Dow Research Institute, Cincinnati, Ohio.
Lewis
J E
JE
D000595:Amino Acid Sequence; D015198:Designer Drugs; D015195:Drug Design; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011663:Pulmonary Surfactants / Q000494:pharmacology* / Q000502:physiology
D015198:Designer Drugs; D011663:Pulmonary Surfactants