Involvement of eosinophils in acute myeloid leukaemia with monosomy 7 demonstrated by fluorescence in situ hybridization.
Monosomy 7 is the commonest monosomy in acute myeloid leukaemia (AML). A patient with AML and monosomy 7 was investigated by fluorescence in situ hybridization. Monosomy 7 could be demonstrated in the blasts and also in mature eosinophils, but apparently not in lymphocytes. Monosomy 7 may occur in a multipotential myeloid progenitor cell as part of the multi-step leukaemogenic process.
Kwong
Y L
YL
University Department of Medicine, Queen Mary Hospital, Hong Kong.
Chan
L C
LC
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002897:Chromosomes, Human, Pair 7; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D009006:Monosomy