[Pharmacokinetic validation of intra-arterial lymphotropic antibiotic therapy of pyo-inflammatory diseases of organs of the peritoneal cavity].
Intraarterial infusion of antibiotics provided a 1.39-2.84-fold regional increase in the antibiotic concentration as compared to that after the intravenous infusion in the organs and tissues of the abdominal cavity affected by an inflammatory process. Regional intraarterial lymphostimulation provided a 1.31-1.64-fold increase in the antibiotic resorption from the affected organs and tissues of the abdominal cavity to the relevant regional lymph nodes. Combined intraarterial administration of the antibiotic and lymphostimulant made it possible to provide high antibiotic concentrations in both the affected organs and tissues of the abdominal cavity and the respective portions of the regional lymphatic system.
Buianov
V M
VM
Danilov
K Iu
KIu
Stupin
I V
IV
Kharitonov
S V
SV
D000818:Animals; D005839:Gentamicins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007269:Injections, Intra-Arterial; D008208:Lymphatic System / Q000187:drug effects* / Q000378:metabolism; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical
D005839:Gentamicins
Farmakokineticheskoe obosnovanie vnutriarterial'noĭ limfotropnoĭ antibiotikoterapii gnoĭno-vospalitel'nykh zabolevaniĭ organov briushnoĭ polosti.