p53: a cellular Achilles' heel revealed.
Many human cancers result from the inactivation of p53, a protein central to DNA repair. Recent papers reporting the structures of two p53 domains help to rationalize the wealth of information about this protein.
Burley
S K
SK
Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021.
D000595:Amino Acid Sequence; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D008958:Models, Molecular; D009369:Neoplasms / Q000378:metabolism; D017433:Protein Structure, Secondary; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism
D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D016159:Tumor Suppressor Protein p53