[Effects of the degree of fish oil oxidation on the state of xenobiotic metabolism enzymes].
Wistar male rats received polysynthetic diets incorporating lard or fish of different oxidation degree as the sourse of fat. The feeding lasted 4 weeks. In the liver of rats on fish oil diet the activity of the enzymes of xenobiotic metabolism phase I (monooxigenase system, epoxide hydrolase, carboxyl esterase) and phase II (native and activated UDP-glucuronosyl transferase, glutathione transferase) located both in microsoma membranes and in cytozole was higher than in the animals on lard diet. The enzyme activity was much more enhanced in the use of oxidated fish oil. No effect of fish oil on serum and lysosome enzyme activity and rat hepatic structure was found.
Kravchenko
L V
LV
Kuz'mina
E E
EE
Avren'eva
L I
LI
Pozdniakov
A L
AL
Kulakova
S N
SN
Levachev
M M
MM
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D004851:Epoxide Hydrolases / Q000378:metabolism; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D015262:Xenobiotics / Q000378:metabolism*
D005395:Fish Oils; D015262:Xenobiotics; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D002265:Carboxylic Ester Hydrolases; D004851:Epoxide Hydrolases
Vliianie stepeni okislennosti ryb'ego zhira na funktsional'noe sostoianie fermentov metabolizma ksenobiotikov.