Hepatocellular-cholestatic liver injury due to amoxycillin-clavulanic acid combination.
Two cases (first cases from Poland and Eastern Europe) with liver injury due to amoxycillin-clavulanic acid (augmentin) are reported. Pruritus and jaundice were the main symptoms. Liver biopsy revealed mixed hepatocellular-cholestatic liver injury in both cases. In addition, in one case the microgranulomalike aggregate of inflammatory cells was found. Clinical and laboratory abnormalities returned to normal within 13 weeks.
Habior
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A
Department of Gastroenterology, Medical Center for Postgraduate Education, Warsaw, Poland.
Walewska-Zielecka
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B
Butruk
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E
D000658:Amoxicillin / Q000008:administration & dosage / Q000009:adverse effects; D019980:Amoxicillin-Potassium Clavulanate Combination; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006099:Granuloma / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000188:drug therapy; D014069:Tonsillitis / Q000188:drug therapy
D002969:Clavulanic Acids; D004338:Drug Combinations; D019818:Clavulanic Acid; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin