Plasma interleukin 8 levels are increased by hemodialysis.
The effects of hemodialysis on plasma interleukin 8 (IL-8) levels and the expression of IL-8 mRNA in peripheral blood mononuclear cells (PBMC) were studied in uremic patients undergoing maintenance hemodialysis (HD) using regenerated cellulose dialyzers. The plasma IL-8 levels in the patients after HD sessions were significantly higher than before HD. Comparison of the IL-8 mRNA levels obtained from PBMC before and after HD indicated that the expression of IL-8 mRNA was increased by HD. The enhancement of production of IL-8 in PBMC during HD may be responsible for inflammatory complications and impaired host defense in HD patients.
Miyazaki
T
T
Department of Endocrinology and Metabolism, Nagoya University, Japan.
Niwa
T
T
Sato
M
M
Kambe
F
F
Maeda
K
K
Seo
H
H
D000328:Adult; D000368:Aged; D001483:Base Sequence; D002482:Cellulose; D005260:Female; D005786:Gene Expression Regulation; D005921:Glomerulonephritis / Q000097:blood / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000209:etiology; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008969:Molecular Sequence Data; D009000:Monocytes / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation
D016209:Interleukin-8; D008567:Membranes, Artificial; D012333:RNA, Messenger; D002482:Cellulose