Sequence of the 5'-flanking region of the gene encoding human muscle glycogen synthase.
The 5'-flanking region of the gene encoding human muscle glycogen synthase was isolated from a human placental genomic library and sequenced. The sequence is TATA-less and G+C-rich, and putative transcription-controlling sequences were identified. Furthermore, a simple (dC-dA)n sequence repeat was identified about 4 kb upstream from the start codon. This sequence was highly polymorphic and five alleles were typed in the Japanese population using the polymerase chain reaction.
Nakayama
T
T
Medical Research Institute, Nihon University School of Medicine, Tokyo, Japan.
Esumi
M
M
Nakabayashi
H
H
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000378:metabolism; D017931:DNA Primers; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D015698:Genomic Library; D006006:Glycogen Synthase / Q000096:biosynthesis / Q000235:genetics*; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009132:Muscles / Q000201:enzymology*; D010920:Placenta / Q000201:enzymology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011401:Promoter Regions, Genetic; D051381:Rats; D012091:Repetitive Sequences, Nucleic Acid; D016385:TATA Box; D014157:Transcription Factors / Q000378:metabolism
D017931:DNA Primers; D004276:DNA, Satellite; D014157:Transcription Factors; D004247:DNA; D006006:Glycogen Synthase