[The apolipoprotein E-epsilon 4 allele is a risk factor for Alzheimer disease with early and late onset].
The apolipoprotein E genotype was determined in 50 patients with clinically diagnosed and prospectively confirmed Alzheimer's disease of mild to moderate severity and in 50 healthy age- and sex-matched controls. The frequency of the epsilon 4 allele was increased in the patients irrespective of the age at onset and of a possible familial transmission of the disease. It was associated with a relative risk of 2.97. In patients who experienced first symptoms after the age of 65 years there was an inverse correlation between the number of epsilon 4 alleles and age at onset. The results suggest that in the absence of amyloid precursor protein mutations and of a gene which has not yet been precisely localized on chromosome 14, apolipoprotein E is involved in the pathogenesis of Alzheimer's disease. It probably exerts its influence by an acceleration or retardation of amyloid formation and/or tau hyperphosphorylation.
Kurz
A
A
Psychiatrische Klinik, Technischen Universität München.
Lautenschlager
N
N
Haupt
M
M
Zimmer
R
R
von Thülen
B
B
Altland
K
K
Lauter
H
H
Müller
U
U
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers
Das Apolipoprotein E-epsilon 4-Allel ist ein Risikofaktor für die Alzheimer-Krankheit mit frühem und spätem Beginn.