Pharmacokinetics of rec-hirudin in healthy volunteers after intravenous administration.
The pharmacokinetics of recombinant hirudin (rec-hirudin, Ciba-Geigy, CGP 39,393) in healthy volunteers after iv administration was investigated on the basis of the data from five different studies. A total of 77 plasma profiles following a single iv bolus dose of either 0.1, 0.3, 0.5, or 1 mg/kg of rec-hirudin was used for the evaluation. Plasma concentrations and especially AUC were proportional to the dose. Kinetics of rec-hirudin after a bolus iv injection were best described by a three-compartment open model. Mean apparent terminal half-life was 2.8 hr and the total clearance 0.138 L/hr per kg.
Cardot
J M
JM
Centre de Recherche Biopharmaceutique, Laboratories Ciba-Geigy, Rueil-Malmaison, France.
Lefèvre
G Y
GY
Godbillon
J A
JA
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D006207:Half-Life; D006629:Hirudins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D008956:Models, Chemical; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000493:pharmacokinetics
D006629:Hirudins; D011994:Recombinant Proteins