title: Mesangial cell ion transport and tubuloglomerular feedback.
abstract: Mesangial cells possess Ca(2+)-activated Cl- channels, Ca(2+)-activated K+ channels, voltage-gated Ca2+ channels, ATP-sensitive K+ channels, and two types of nonselective cation channels. Angiotensin II and arginine vasopressin depolarize the membrane. This membrane depolarization is caused by the activation of Ca(2+)-activated Cl- and Ca(2+)-activated nonselective cation channels through an elevation of intracellular Ca2+ concentration. The Ca(2+)-independent nonselective cation channel is activated by platelet-derived growth factor and is a candidate for the receptor-activated Ca2+ influx system. It has been suggested that macula densa Cl- reabsorption determines the Cl- concentration of juxtaglomerular apparatus interstitial fluid and thereby affects the resistance of afferent arterioles. In addition, angiotensin II-mediated and arginine vasopressin-mediated mesangial cell Ca2+ signals and contraction are attenuated via prostaglandin production by the mesangial cells themselves when the ambient Cl- concentration is reduced. Thus, Cl- plays an essential role in the tubuloglomerular feedback mechanism. The intracellular Ca2+ concentration appears to be important for the signal transduction mechanism of tubuloglomerular feedback. The ionic channels on the mesangial cell membrane may participate in controlling the intracellular Ca2+ concentration. The association of disturbed tubuloglomerular feedback and the development of hypertension has recently been reported.
authors: First Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
authors: H
authors: H
authors: Matsunaga
authors: N
authors: N
authors: Yamashita
authors: T
authors: T
authors: Okuda
authors: K
authors: K
authors: Kurokawa
mesh_terms: D000818:Animals; D001692:Biological Transport; D005246:Feedback; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007477:Ions; D007678:Kidney Glomerulus / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology*
chemical_list: D007477:Ions