[Type II Charcot-Marie-Tooth and dopa-sensitive Parkinson disease].
The occurrence of a dopa-sensitive parkinsonian syndrome 25 years after a neuropathy suggestive of Charcot-Marie-Tooth disease type II raised the possibility of a relationship between these two diseases. Apart from Machado-Joseph-Azorean disease, an association of this kind seems to be exceptional and it can not be excluded that it was fortuitous. However, the recent description of 7 familial and sporadic cases of a syndrome characterized by a peripheral neuropathy, familial in 5 of the 7 cases, followed, a few years later, by a dopa-sensitive parkinsonian syndrome, makes it possible to consider that this association might have a common genetic origin.
Tranchant
C
C
Service de Neurologie II, Hôpitaux Universitaires de Strasbourg.
Ruh
D
D
Warter
J M
JM
D002607:Charcot-Marie-Tooth Disease / Q000150:complications*; D004295:Dihydroxyphenylalanine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000150:complications* / Q000188:drug therapy
D004295:Dihydroxyphenylalanine
Maladie de Charcot-Marie-Tooth type II et syndrome parkinsonien dopasensible.