Induction of insulin antibodies and insulin allergy under alpha-interferon treatment of renal cell carcinoma in a patient with insulin-treated diabetes mellitus--a case report.
The induction of insulin antibodies and the development of an insulin allergy were observed in a male diabetic patient treated with insulin during alpha-IFN therapy of renal cell carcinoma. Diabetes and renal cell carcinoma were diagnosed at the same time. The patient was treated with biosynthetic human insulin and nephrectomy was performed. Four months later, antineoplastic chemotherapy was started (alpha-IFN, vinblastin). Six weeks after initiation of alpha-IFN injections, the patient reported signs of insulin allergy. Significant titers of insulin antibodies of both the IgG and IgE subclasses were found in the serum at that time and during follow-up, but not before the treatment with alpha-IFN. None of the other autoantibodies investigated were positive.
Krug
J
J
City Hospital Leipzig, Germany.
Fritzsch
J
J
Aust
G
G
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000628:therapy*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D007328:Insulin / Q000276:immunology*; D007330:Insulin Antibodies / Q000096:biosynthesis*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D011994:Recombinant Proteins
D007328:Insulin; D007330:Insulin Antibodies; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins