PD135158, a CCK-B antagonist, reduces "state," but not "trait" anxiety in mice.
It has recently been proposed that Balb/c neophobic responses in a free exploratory paradigm are related to "trait" anxiety, while the behavior of mice in the light/dark choice test paradigm is related to "state" anxiety. The purpose of this study was to assess the action of the CCK-B receptor antagonist PD135158 in both models. Results show that PD135158 was effective in the light/dark choice test but not on the Balb/c neophobic reactions in the free exploratory situation. It is suggested that PD135158 is specially effective in state anxiety induced by fear provoking situations.
Belzung
C
C
Laboratoire d'Ethologie et de Psychophysiologie, UFR Sciences et Techniques, Tours, France.
Pineau
N
N
Beuzen
A
A
Misslin
R
R
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D003624:Darkness; D005106:Exploratory Behavior / Q000187:drug effects; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects
D014151:Anti-Anxiety Agents; D007211:Indoles; C065600:PD 135158; D008536:Meglumine; D002766:Cholecystokinin