title: Cholesterol absorption and cholesterol and bile acid synthesis in two brothers with IDDM and diarrhea.
abstract: OBJECTIVE
  To determine the best possible treatment for two brothers who had IDDM and bile acid malabsorption-associated disabling diarrhea that was resistant to cholestyramine, antibiotics, clonidine, loperamide, or anticholinergic drugs.
  
  
  METHODS
  Our study paired these two brothers with control subjects. Serum noncholesterol sterols and fecal elimination of cholesterol and plant sterols were quantitated by gas-liquid chromatography.
  
  
  RESULTS
  Fecal losses of bile acids exceeded four to six times the control values, and cholesterol synthesis was increased two to three times. Cholesterol absorption efficiency and serum cholesterol concentrations were, respectively, within the high and low control range.
  
  
  CONCLUSIONS
  Bile acid malabsorption might have resulted from deranged intestinal motility, possibly contributed by gastrointestinal neuropathy, and some genetic factor.
authors: Second Department of Medicine, University of Helsinki, Finland.
authors: H
authors: H
authors: Gylling
authors: T A
authors: TA
authors: Miettinen
mesh_terms: D000328:Adult; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D002784:Cholesterol / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D003967:Diarrhea / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013261:Sterols / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D013261:Sterols; D002784:Cholesterol