title: Respiratory function after cardiopulmonary bypass: a comparison of bubble and membrane oxygenators.
abstract: A consecutive sample of 500 adults undergoing cardiac surgery was randomly allocated to extracorporeal circulation with either a Bard bubble oxygenator H1700 or a Bard membrane oxygenator HF5700 (Bard Ltd, Crawley, UK). Alveolar-arterial oxygen tension gradient (AaDO2) was calculated prebypass, then 20, 90, 180, and 420 minutes postbypass. Preoperative, initial postoperative, and first-day postoperative chest x-rays were assigned an extravascular lung water (EVLW) score and an atelectasis score. There was a comparable increase in AaDO2 after bypass in each group. The increase in EVLW score was significantly greater in the bubble group (mean 2.91, 95% CI 2.28-3.54) than the membrane group (mean 2.06, 95% CI 1.43-2.69) for the initial postoperative x-rays (P < 0.01) and also for the x-rays on the first postoperative day (P < 0.01). The increase in atelectasis score was significantly greater in the bubble group (mean 1.06, 95% CI 0.94-1.18) than the membrane group (mean 0.86, 95% CI 0.74-0.98) for the initial postoperative x-rays (P < 0.01) but not for the x-rays on the first postoperative day. There was no difference in duration of ventilation, intensive care, hospital stay, or hospital mortality between bubble and membrane groups. Although there was a statistically significant difference in x-ray scores between oxygenator groups, neither intrapulmonary shunting nor clinical outcome was influenced by the type of oxygenator used during bypass.
authors: Western Infirmary, Glasgow, Scotland.
authors: W G
authors: WG
authors: Reeve
authors: S M
authors: SM
authors: Ingram
authors: D C
authors: DC
authors: Smith
mesh_terms: D000328:Adult; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D003422:Critical Care; D015633:Extravascular Lung Water / Q000502:physiology; D005260:Female; D006801:Humans; D007902:Length of Stay; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010106:Oxygenators; D010107:Oxygenators, Membrane; D001261:Pulmonary Atelectasis / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000502:physiology; D011859:Radiography; D012119:Respiration / Q000502:physiology*; D012121:Respiration, Artificial; D015996:Survival Rate; D013997:Time Factors
chemical_list: D010100:Oxygen