Differences in serum interleukin-6 (IL-6) between healthy dextral and non-dextral subjects.
Serum interleukin-6 (IL-6) was measured in picograms/ml pg/ml using an immunoassay (ELISA) in healthy individuals (n = 148), of whom 128 were classified as dextral and 20 as non-dextral, as per a laterality questionnaire. Only 3 (15%) non-dextral individuals had serum IL-6 levels above the lower limit of the assay sensitivity as compared to 59 (46%) of dextral individuals (P < 0.013). There were no significant correlations between previously determined mitogen stimulated interleukin-2 production and autoantibodies in a subset of the same individuals. While this data does not provide casual information, it adds to the evidence of the asymmetric regulation of immune functions by the cerebral hemispheres.
Chengappa
K N
KN
Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute and Clinic, Pittsburg, PA 15213-2593.
Ganguli
R
R
Yang
Z W
ZW
Schurin
G
G
Brar
J S
JS
Rosenbleet
J A
JA
Rabin
B S
BS
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007839:Functional Laterality; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D012016:Reference Values; D011795:Surveys and Questionnaires
D001323:Autoantibodies; D015850:Interleukin-6