Delayed-type allergenicity of triforine (Saprol).
The delayed-type allergenicity of triforine (Saprol), 1,4-bis (2,2,2-trichloro-1-formamidoethyl) piperazine, was studied. In a mass examination of chrysanthemum growers among whom triforine was commonly used, the highest rate of positive patch test reaction was seen to triforine (17%) among the 7 pesticides and chrysanthemum extracts tested. A higher prevalence rate of work-related skin symptoms was seen in subjects with a positive patch test reaction to triforine (44%) than in those with negative reactions to all allergens tested (15%) (p < 0.05). 12 subjects (67%) with positive patch test reactions to triforine were also positive to dichlorvos (DDVP), with a high kappa coefficient (0.65). The grading of guinea pig maximization test to triforine was grade IV (66%), defined as "strong". Cross-sensitization between triforine and dichlorvos was also shown. The present results confirm that triforine is capable of including delayed-type allergy among chrysanthemum growers and of showing cross-reactivity with dichlorvos.
Ueda
A
A
Department of Environmental Medicine, Faculty of Medicine, Kagoshima University, Japan.
Aoyama
K
K
Manda
F
F
Ueda
T
T
Kawahara
Y
Y
D000328:Adult; D000818:Animals; D011723:Chrysanthemum cinerariifolium; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000276:immunology; D004006:Dichlorvos / Q000009:adverse effects; D005260:Female; D005659:Fungicides, Industrial / Q000009:adverse effects*; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010879:Piperazines / Q000009:adverse effects*
D005659:Fungicides, Industrial; D010879:Piperazines; D004006:Dichlorvos; C012591:triforine