title: Endothelin-induced vasoconstriction in rabbit nasal mucosa.
abstract: Nasal blood flow is finely regulated by local release of neurotransmitters, neuropeptides and other bioactive molecules acting via paracrine mechanisms. We have investigated the effects of endothelin-1 (ET-1), a potent vasoconstrictor peptide, on the blood perfusion of rabbit nasal mucosa by laser Doppler flowmetry. After injection with ET-1, a potent and prolonged nasal vasoconstriction was observed. ET-immunoreactivity has previously been detected in nasal tissues and it is therefore suggested that ET-1 may participate in the regulation of nasal blood flow via paracrine mechanisms.
authors: Department of Otolaryngology, University of Pavia, Italy.
authors: M
authors: M
authors: Benazzo
authors: A
authors: A
authors: Casasco
authors: P
authors: P
authors: Lovotti
authors: A
authors: A
authors: Icaro Cornaglia
authors: M
authors: M
authors: Casasco
authors: J M
authors: JM
authors: Polak
mesh_terms: D000818:Animals; D016232:Endothelins / Q000494:pharmacology*; D005260:Female; D017078:Laser-Doppler Flowmetry; D009297:Nasal Mucosa / Q000098:blood supply / Q000187:drug effects*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D016232:Endothelins