Phospholipid base-exchange in brain microvessels.
The capillary endothelium of cerebral microvessels plays an important role in homeostasis within the central nervous system. The flux of fluids and solutes takes place through the lipid matrix of plasma membranes and the maintenance of their structural composition is necessary for cell membrane permeability and the cellular transport systems. Few studies have been carried out to clarify the relationships between brain microvessel lipid metabolism and the role of this metabolism. We have studied a particular aspect of the phospholipid metabolism, i.e. their hydrosoluble head group exchange with free choline, ethanolamine or serine, in capillaries from brains of both 4 month- old and 24 month-old rats. The results obtained indicate that microvessels possess the biochemical machinery of base-exchange reaction, whose activity rate appears unaffected by age.
Terracina
L
L
Istituto di Biochimica e Clinica Medica, Università di Perugia.
De Medio
G E
GE
Trovarelli
G
G
Gaiti
A
A
D000375:Aging / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002196:Capillaries / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D019856:Ethanolamine; D004983:Ethanolamines / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D066298:In Vitro Techniques; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D012694:Serine / Q000378:metabolism
D004983:Ethanolamines; D010743:Phospholipids; D012694:Serine; D019856:Ethanolamine; D002794:Choline