title: Deficiency of endogenous arginine synthesis provokes hypertension by exhausting substrate arginine for nitric oxide synthesis.
abstract: Effect of deficiency in endogenous arginine synthesis was studied in connection with NO synthesis and blood pressure. Rats with massive resection of small intestine were fed an arginine-free diet (AF rats) for 24 days. Control rats were pair-fed an isonitrogenous and isocaloric arginine-replete diet. AF rats lost weight by a mean of 28 g whereas control rats kept original weight. Urinary excretion of nitrate and cGMP was reduced in AF rats by about 40% after the feeding. Blood pressure became elevated by 20-25 mmHg in AF rats after the feeding. The concentrations of arginine in muscle and plasma of AF rats were reduced to 17 and 39%, respectively, of control rats. AF rats may be a novel animal model for the in vivo study of NO.
authors: Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
authors: Y
authors: Y
authors: Wakabayashi
authors: E
authors: E
authors: Yamada
authors: T
authors: T
authors: Yoshida
authors: H
authors: H
authors: Takahashi
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000096:biosynthesis* / Q000172:deficiency*; D001794:Blood Pressure; D003404:Creatinine / Q000652:urine; D006152:Cyclic GMP / Q000652:urine; D004435:Eating; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007421:Intestine, Small / Q000502:physiology* / Q000601:surgery; D009132:Muscles / Q000378:metabolism; D009566:Nitrates / Q000652:urine; D009569:Nitric Oxide / Q000096:biosynthesis*; D009963:Orotic Acid / Q000652:urine; D011674:Pulse; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D015431:Weight Loss
chemical_list: D000596:Amino Acids; D009566:Nitrates; D009569:Nitric Oxide; D009963:Orotic Acid; D001120:Arginine; D003404:Creatinine; D006152:Cyclic GMP