title: Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial protein map to HSA9 and MMU2.
abstract: The lipocalin superfamily encompasses a large set of quite distantly related proteins that act as carriers for small, lipophilic molecules. The lipocalin genes coding for orosomucoid, the alpha 1-microglobulin/bikunin precursor, and the major urinary protein map to MMU4, while their human counterparts map to the homologous HSA9q34 area where three other lipocalin genes for complement C8 gamma chain (C8G), progestagen-associated endometrial protein (PAEP), and prostaglandin D synthase (PTGDS) are also located. By linkage analyses in an interspecific backcross progeny in mouse, the Lcn2 gene coding for the oncogenic lipocalin 24p3, as well as the 3 lipocalin genes for C8G, PTGDS, and PAEP, have now been assigned to MMU2. The first three genes map to proximal MMU2, which is known to be homologous to HSA9q34. Paep is more distally located, which extends the number of regions with conserved syntenies between HSA9q34 and MMU2. By in situ hybridization, the human LCN2 gene maps to HSA9q34. Our data indicate that the lipocalin locus arrangement in the human/mouse ancestor is closer to that found at HSA9q than to that in the MMU genome.
authors: Institute National de la Santé et de la Recherche Médicale, Unit-78, Boisguillaume, France.
authors: P
authors: P
authors: Chan
authors: D
authors: D
authors: Simon-Chazottes
authors: M G
authors: MG
authors: Mattei
authors: J L
authors: JL
authors: Guenet
authors: J P
authors: JP
authors: Salier
mesh_terms: D000209:Acute-Phase Proteins; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D003185:Complement C8 / Q000235:genetics*; D003433:Crosses, Genetic; D005796:Genes; D008040:Genetic Linkage; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D019746:Intramolecular Oxidoreductases; D007535:Isomerases / Q000235:genetics*; D000071068:Lipocalin-2; D054834:Lipocalins; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D005810:Multigene Family; D009115:Muridae / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics*; D011257:Pregnancy Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D051381:Rats; D013045:Species Specificity
chemical_list: D000209:Acute-Phase Proteins; D003185:Complement C8; C489046:Gd protein, rat; D000071816:Glycodelin; D006023:Glycoproteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D015513:Oncogene Proteins; C045246:PAEP protein, human; C489047:Paep protein, mouse; D011257:Pregnancy Proteins; D011518:Proto-Oncogene Proteins; C071332:Lcn2 protein, mouse; D007535:Isomerases; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase