[In vitro bactericidal activity of seven antibiotics and four combinations against Neisseria meningitidis].
The authors studied, with a time-kill curve method, in a derived Hafiz medium broth the bactericidal effect of 7 antibiotics and 4 associations against N. meningitidis. Their results show a better bactericidal effect for penicillin G, ampicillin and chloramphenicol. Pefloxacin and ceftriaxon are less efficient. The association ampicillin + chloramphenicol in vitro shows no antagonism and has a good bactericidal activity at the early stages of bactericidal killing with N. meningitidis.
Nizou
J Y
JY
Laboratoire de Biologie Médicale, HIA Begin, Saint-Mandé, France.
Cavallo
J D
JD
Crenn
Y
Y
Bartoli
M
M
Meyran
M
M
D000667:Ampicillin / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D066298:In Vitro Techniques; D009345:Neisseria meningitidis / Q000187:drug effects*; D015366:Pefloxacin / Q000494:pharmacology*; D010400:Penicillin G / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D015572:Spiramycin / Q000494:pharmacology
D015366:Pefloxacin; D002701:Chloramphenicol; D002443:Ceftriaxone; D000667:Ampicillin; D015572:Spiramycin; D010400:Penicillin G; D012293:Rifampin
Activité bactéricide in vitro de sept antibiotiques et de quatre associations sur Neisseria meningitidis.