[Biological study on prognosis of laryngeal carcinoma with regional metastatic lymph nodes].
The purpose of this study is to find out the biological feature of laryngeal cancer and metastatic lymph nodes with DNA Image Analysis, Argyrophilic Nucleolar Organizer Region (AgNOR), Carcinoembryonic Antigen (EA) and Estrogen Receptor (ER) 30 patients were included in this study. It was found that carcinomatous tissues showed a statistically significantly higher DNA content, AgNOR content, and positive reaction of CEA and ER than those of normal tissue (P < 0.01). Paired comparisons were performed in primary tumor and metastases and didn't show statistical difference (P > 0.05). The group with survival time over 5 years had a significantly lower DNA content, AgNOR content, CEA positive reaction of metastases and higher ER positive reaction of metastases than those with less than 5 years survival (P < 0.01). But there no was consistant relationship between primary tumor CEA or ER positive reaction and survival time (P > 0.05). The patients who accepted radiotheraphy had better prognosis than those who didn't (P < 0.05). The above results indicate that the combined analysis of metastases and primary tumor will provide a good feature for biological activity. In addition, radiotherapy before and after operation will be beneficial.
Xia
Y
Y
Shandong Provincial Hospital, Jinan.
Luo
Z
Z
Liang
M
M
D002272:Carcinoembryonic Antigen / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000737:chemistry / Q000473:pathology*; D008207:Lymphatic Metastasis; D009697:Nucleolus Organizer Region / Q000737:chemistry; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis; D016622:Silver Staining
D002272:Carcinoembryonic Antigen; D004273:DNA, Neoplasm; D011960:Receptors, Estrogen