Effects of neutron-gamma irradiation on striatal D1 and D2 receptor distribution.
The early effects of neutron irradiation on the striatal D1 and D2 dopaminergic receptor distribution were investigated by quantitative receptor autoradiography. One hour after exposure at the dose of 8.4 Gy, an increase of D1 (+21%) and D2 (+25%) receptor density was observed in the striatum, located at the most anterior levels, containing the richest plexus of dopaminergic fibers afferent from the substantia nigra. Regional differences in changes of D1 and D2 receptor density were observed. This up-regulation could contribute to the development of early radio-induced neuro-vegetative syndrome.
Martin
C
C
Unité de Radioprotection, Centre de Recherches du Service de Santé des Armées, La Tronche, France.
Rubio
I
I
Burckhart
M F
MF
Fatome
M
M
D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D009502:Neutrons; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000378:metabolism / Q000528:radiation effects*; D017448:Receptors, Dopamine D2 / Q000378:metabolism / Q000528:radiation effects*; D012016:Reference Values; D013134:Spiperone / Q000378:metabolism; D014316:Tritium; D014916:Whole-Body Irradiation
D001552:Benzazepines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D014316:Tritium; D013134:Spiperone