[Immunohistochemical study on diamine oxidase in mammary cancer and adenosis].
In recent years, an obvious increase of diamine oxidase (DAO) in both blood and tumor tissues has been reported In this assay we observed an increased content and distribution of DAO in mammary cancer and adenosis by immunohistochemistry. The results show that: 1. DAO staining was strongly positive in mammary cancer and the brownish granules were spread over the cytoplasm; 2. In the adenosis of mammary gland, DAO was positive or weakly positive, but those hyperplastic ducts in it appeared to be strongly positive and the brownish granules distributed spotted; 3. The normal mammary tissue presented weak positive or negative DAO reaction. These observations indicated that the malignant tumor and hyperplastic changes of mammary gland induce increase of DAO in the cells, and the higher the DAO content, the greater the possibility of malignant changes.
Lu
J Y
JY
Department of Pathology, 304th Hospital of PLA, Beijing.
Yang
Y
Y
Liang
Y J
YJ
D000230:Adenocarcinoma / Q000201:enzymology*; D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001940:Breast / Q000201:enzymology; D001943:Breast Neoplasms / Q000201:enzymology*; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
D014408:Biomarkers, Tumor; D006631:Amine Oxidase (Copper-Containing)