title: Tiapride in the prevention of relapse in recently detoxified alcoholics.
abstract: BACKGROUND
  The aim was to investigate the effect of tiapride (100 mg three times a day for at least one month) on outcome following detoxification.
  
  
  METHODS
  The setting was a tertiary referral centre. The study design was randomised, double-blind, and placebo-controlled. One hundred routinely admitted alcohol-dependent patients were entered, and 54 completed the trial. Outcome was assessed by considering drinking status at three months and six months follow-up, and by comparing psychological status at intake and follow-up using the Crown-Crisp Experiential index, the Litman Self-esteem scale and a Satisfaction with Life Situations scale. We also compared performance over the six months before admission with the three and six months of follow-up on measures of health, social and drinking variables.
  
  
  RESULTS
  Tiapride proved better (usually at statistically highly significant levels) than placebo at promoting: abstinence, self-esteem, and satisfaction with life situations; and at reducing: alcohol consumption, use of health service resources, and levels of neuroticism.
  
  
  CONCLUSIONS
  Tiapride merits serious consideration in the longer-term treatment of alcoholic patients.
authors: Bexley Hospital, Kent.
authors: G K
authors: GK
authors: Shaw
authors: S
authors: S
authors: Waller
authors: S K
authors: SK
authors: Majumdar
authors: J L
authors: JL
authors: Alberts
authors: C J
authors: CJ
authors: Latham
authors: G
authors: G
authors: Dunn
mesh_terms: D000428:Alcohol Drinking; D000437:Alcoholism / Q000517:prevention & control / Q000534:rehabilitation*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D010549:Personal Satisfaction; D010919:Placebos; D012008:Recurrence; D012649:Self Concept; D012917:Social Adjustment; D013695:Temperance; D013976:Tiapamil Hydrochloride / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D013976:Tiapamil Hydrochloride