title: Topical antiseptic mouthwash in oncological surgery of the oral cavity and oropharynx.
abstract: A multivariant analysis of the value of the use of a pre-operative topical antiseptic mouthwash to reduce the incidence of post-operative wound complications in 106 consecutive patients undergoing head and neck surgery involving the oral cavity or oropharynx was carried out at the University of Iowa, Department of Otolaryngology--Head and Neck Surgery. An oral presentation employing povidone-iodine solution was used for 43 patients. The remaining 63 patients studied received no oral presentation. Unfavourable wound outcome was not associated with age, sex, presence and condition of teeth, or serious pre-existing medical illnesses. A significant correlation was found between post-operative wound breakdown and type of closure, stage of disease, and previous operation or radiotherapy. The use of an oral preparation correlated significantly with favourable wound outcome independent of all other variables (p < 0.01). Our data support the use of a topical antiseptic mouthwash to reduce the incidence of post-operative wound complications in surgery of the oral cavity and oropharynx.
authors: Division of Otolaryngology--Head and Neck Surgery, University of Chicago Medical Centre, IL 60637.
authors: M I
authors: MI
authors: Redleaf
authors: C A
authors: CA
authors: Bauer
mesh_terms: D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D007455:Iodine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000601:surgery; D009067:Mouthwashes / Q000627:therapeutic use*; D015999:Multivariate Analysis; D009959:Oropharyngeal Neoplasms / Q000601:surgery; D011292:Premedication; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D007455:Iodine