Effect of procainamide on platelet adhesion in rats.
Effect of procainamide on platelet adhesion in rats was studied with the improved rotating glass sphere method. Procainamide of 136.0, 34.0, 8.5 mumol.L-1 in vitro and 10 mg.kg-1 in vivo inhibited significantly the platelet adhesion with the inhibitory rates of 56%, 28%, 8%, and 24%, respectively. It showed that procainamide given in vitro or in vivo produced an inhibition on platelet adhesion.
Yang
Y S
YS
Department of Physics, First Military Medical University, Guangzhou, China.
Zhou
Y X
YX
Ma
F B
FB
Shan
C W
CW
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011342:Procainamide / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011342:Procainamide