title: Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma.
abstract: We investigated the mechanism of polyclonal B cell differentiation in mantle cell lymphoma (MCL) using peripheral blood mononuclear cells (PBMC) from a patient with MCL in leukemic stage presenting polyclonal hypergammaglobulinemia. Patient T cells not only responded to autologous non-T cells but induced polyclonal production of IgG in vitro. Flow cytometric analysis of PBMC showed the increased conversion of CD4+ T cells from the naive to the memory state. We propose the possible mechanism that autoreactive T cells may be involved in polyclonal B cell differentiation in this monoclonal B cell disorder.
authors: Department of Internal Medicine, Akita University School of Medicine, Japan.
authors: M
authors: M
authors: Hirokawa
authors: M
authors: M
authors: Lee
authors: A
authors: A
authors: Kitabayashi
authors: A
authors: A
authors: Chubachi
authors: T
authors: T
authors: Itoh
authors: I
authors: I
authors: Miura
authors: M
authors: M
authors: Saitoh
authors: A B
authors: AB
authors: Miura
mesh_terms: D001402:B-Lymphocytes / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000502:physiology*