Decreased T3 and T4 levels following topical application of povidone-iodine in premature neonates.
Thyroid function and iodine levels of 30 preterm neonates were examined before and up to five days after topical exposure to 10% povidone-iodine application. Urinary iodine excretion significantly increased in the group closest to term (8.9 +/- 1.2 mg I/g creatinine x 10) vs controls (3.5 +/- 0.5 mg; p < 0.01). T3 levels significantly decreased at all sub-group gestational ages vs controls (p < 0.01-0.05). Similarly, both FT4 and TT4 levels were lower in the subgroups vs controls (p < 0.01-0.05). TSH levels however did not rise in any group. These data suggest partial failure of thyroid hormone synthesis, in a population of high-risk infants possibly already exhibiting features of the euthyroid-sick syndrome. Topical iodine-containing antiseptic solutions should be used with caution in this population since these antiseptics may modify serum thyroid hormone concentrations rapidly.
AvRuskin
T W
TW
Department of Pediatrics, Brookdale Hospital Medical Center, State University of New York, Brooklyn 11212.
Greenfield
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E
Prasad
V
V
Greig
F
F
Juan
C S
CS
D000287:Administration, Topical; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D007455:Iodine / Q000652:urine; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000009:adverse effects*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D011206:Povidone-Iodine; D007455:Iodine; D013974:Thyroxine