[Effects of opioid analgesics on pulmonary ventilation and metabolism in patients with acute postoperative pain].
Opioid analgesics buprenorphine, nubain, and morphine were used in 33 patients suffering from acute postoperative pain on days 1-3 after operations on the lungs, heart and main vessels, abdominal organs. Buprenorphine was used in dose 0.01 mg/kg, nubain in dose 0.3 mg/kg, and morphine in dose 0.3 mg/kg. Effects of opioid analgesics on O2 consumption, carbon dioxide exhalation, minute respiration volume, and total energy metabolism were monitored. Effects of buprenorphine on metabolism and ventilation were the most manifest: it lead to reduction of metabolism by 26.2% and minute respiration volume by 36%. Nubain had no noticeable effect on metabolism or ventilation parameters. Morphine lead to moderately expressed changes in metabolism and ventilation reducing metabolism by 12.5% and minute respiration volume by 10.3%.
Nikoda
V V
VV
Petrov
R O
RO
Sandrikov
V A
VA
Chizhov
A I
AI
D000208:Acute Disease; D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology* / Q000627:therapeutic use*; D002047:Buprenorphine / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D008875:Middle Aged; D009020:Morphine / Q000494:pharmacology / Q000627:therapeutic use; D009266:Nalbuphine / Q000494:pharmacology / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D000701:Analgesics, Opioid; D002047:Buprenorphine; D009020:Morphine; D009266:Nalbuphine
Vliianie opioidnykh analgetikov na legochnuiu ventiliatsiiu i metabolizm u bol'nykh s ostroĭ posleoperatsionnoĭ bol'iu.