The effects of sodium valproate and its metabolites (5-OH-VPA and 4-OH-VPA) on electroconvulsions in rats.
Effects of sodium valproate (VPA) and the omega-oxidation metabolites (5-OH-VPA and 4-OH-VPA) on the electroconvulsions in rats were analyzed. The drug (100 and 200 mg/kg/day) revealed marked dose-related anticonvulsant effect which manifested themselves by shortening the convulsions time and their intensity. The anticonvulsant effect of the omega-oxidation (50, 100 and 200 mg/kg/day) were weaker compared with the parent drugs.
Sobaniec
W
W
Department of Neurology, Medical School, Białystok, Poland.
Sobaniec-Lotowska
M
M
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004597:Electroshock; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014635:Valproic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000927:Anticonvulsants; C091208:5-hydroxyvalproate; C091207:4-hydroxyvalproate; D014635:Valproic Acid