Kinetics of serum cytokines in adults undergoing peripheral blood progenitor cell transplantation.
We investigated the serum cytokine levels (G-CSF, GM-CSF, IL-1 beta, IL-3 and IL-6) using an ELISA in 14 patients with haematological malignancies undergoing peripheral blood progenitor cell transplantation (PBPCT). Serum G-CSF levels in all patients rose immediately after PBPCT, then gradually decreased as the neutrophil counts began to rise. No detectable serum levels of GM-CSF or IL-1 beta were observed, but serum levels of IL-3 rose transiently immediately following PBPCT. Serum levels of IL-6 rose transiently during a fever in four patients. These observations suggest that G-CSF and IL-3 may contribute to the early haemopoietic reconstitution in PBPCT.
Uchiyama
H
H
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Shimazaki
C
C
Fujita
N
N
Tatsumi
T
T
Yamagata
N
N
Hirata
T
T
Ashihara
E
E
Oku
N
N
Goto
H
H
Inaba
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D016207:Cytokines / Q000493:pharmacokinetics*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000097:blood*; D008223:Lymphoma / Q000097:blood*; D008297:Male; D008875:Middle Aged
D016207:Cytokines