Age-dependent decrease in platelet aggregation in rats.
The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7- to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activation is highly age-dependent, with rats of advanced age showing a lower response than younger rats.
Oshima
K
K
Fuji Chemical Industries Ltd., Toyama, Japan.
Morikawa
T
T
Hagiwara
M
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000375:Aging / Q000097:blood*; D000818:Animals; D003094:Collagen / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D000244:Adenosine Diphosphate; D003094:Collagen