Khusimol, a non-peptide ligand for vasopressin V1a receptors.
In the course of a random screen of various plant extracts, khusimol [1], a non-peptide molecule isolated from the root of Vetiveria zizanioides, was found to competitively inhibit the binding of vasopressin to rat liver V1a receptors (Ki = 50 microM). The 1H- and 13C-nmr spectra of this sesquiterpene alcohol were assigned unambiguously.
Rao
R C
RC
Sanofi Recherche, Toulouse, France.
Serradeil-Le Gal
C
C
Granger
I
I
Gleye
J
J
Augereau
J M
JM
Bessibes
C
C
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D066298:In Vitro Techniques; D008024:Ligands; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D051381:Rats; D017483:Receptors, Vasopressin / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
D008024:Ligands; D000081223:Polycyclic Sesquiterpenes; D017483:Receptors, Vasopressin; D012717:Sesquiterpenes; D001127:Arginine Vasopressin; C091305:khusimol