title: HIV disease progression in 854 women and men infected through injecting drug use and heterosexual sex and followed for up to nine years from seroconversion. Italian Seroconversion Study.
abstract: OBJECTIVE
  To compare the progression of HIV-1 infection in men and women followed up for up to nine years after an accurately estimated date of seroconversion.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  16 HIV outpatient clinics across Italy.
  
  
  METHODS
  321 women and 533 men infected with HIV through injecting drug use or heterosexual sex and with accurately estimated dates of seroconversion.
  
  
  METHODS
  Progression to severe CD4 lymphocytopenia (CD4 lymphocyte count < 200 x 10(6)/l), development of AIDS defining diseases, and death from AIDS.
  
  
  RESULTS
  Thirty two women and 67 men developed AIDS at Kaplan-Meier progression rates of 25% (95% confidence interval 13.8% to 35.5%) and 23% (15.6% to 30.4%), respectively, 7 years after seroconversion. In a Cox proportional hazards model the relative hazard was 0.93 (that is, a slightly lower hazard in women) before and 1.10 (0.70 to 1.72) after adjusting for age, HIV exposure group, and year of seroconversion. When CD4 lymphocytopenia and death from AIDS were used as end points the results were similar, with adjusted relative hazards of 0.95 (0.63 to 1.42) and 0.72 (0.48 to 1.79) respectively. In both women and men the risk of developing AIDS before the CD4 lymphocyte count had declined below 200 x 10(6)/l was small (3% in women, 6% in men). The estimated median count at which AIDS developed in women (34 x 10(6)/l; 10 x 10(6) to 44 x 10(6)) was similar to that for men (44 x 10(6)/l; 22 x 10(6) to 60 x 10(6)).
  
  
  CONCLUSIONS
  There seems to be little evidence for appreciable differences in the natural course of HIV infection between men and women followed up from the time of seroconversion.
authors: Istituto Superiore di Sanità, Laboratorio di Epidemiologia e Biostatistica, Centro Operativo AIDS, Rome, Italy.
authors: A
authors: A
authors: Cozzi Lepri
authors: P
authors: P
authors: Pezzotti
authors: M
authors: M
authors: Dorrucci
authors: A N
authors: AN
authors: Phillips
authors: G
authors: G
authors: Rezza
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality* / Q000635:transmission; D018791:CD4 Lymphocyte Count; D002423:Cause of Death; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000401:mortality; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000401:mortality*