title: Experimental beta beta'-iminodipropionitrile (IDPN) neuropathy: neurofilament profile of sensory, motor and autonomic nerves as seen by immunocytochemistry on whole-mount preparations.
abstract: IDPN-induced changes in a variety of sensory, motor and autonomic nerves were studied by whole-mount immunocytochemistry. A full range of proximo-distal accumulations of neurofilament-like material was found, from paranuclear round bodies in perikarya to distal and preterminal axonal dilations. Conversely, both terminal areas and nodal-paranodal regions of myelinated axons showed striking, sharply localized loss of neurofilament-immunostaining. The latter change, when transport of neurofilaments is halted by IDPN, may indicate their local processing and/or differential transport at nodal-paranodal regions.
authors: Department of Cytomorphology, University of Cagliari, Italy.
authors: G L
authors: GL
authors: Ferri
authors: A
authors: A
authors: Cichi
authors: A
authors: A
authors: Bastone
authors: R M
authors: RM
authors: Gaudio
authors: N
authors: N
authors: Frontali
authors: D
authors: D
authors: Dahl
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000737:chemistry*; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000737:chemistry*; D008297:Male; D009046:Motor Neurons / Q000737:chemistry*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000378:metabolism*; D009475:Neurons, Afferent / Q000737:chemistry*; D009498:Neurotoxins; D009570:Nitriles; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009498:Neurotoxins; D009570:Nitriles; C008110:3,3'-iminodipropionitrile