Penetration of cefotetan into suction skin blister fluid and tissue homogenates in patients undergoing abdominal surgery.
The penetration of cefotetan (2-g intravenous bolus) into the suction blister fluid and tissue homogenates of 11 patients was investigated. Mean concentrations in tissue were significantly lower than contemporary suction blister fluid levels. These data show that the determination of beta-lactam concentrations by the tissue homogenate method may seriously underestimate the actual antibiotic levels in extracellular fluid.
Mazzei
T
T
Department of Pharmacology, University of Florence, Italy.
Tonelli
F
F
Novelli
A
A
Ficari
F
F
Mazzoni
C
C
Anastasi
A
A
Periti
P
P
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D001768:Blister / Q000209:etiology / Q000378:metabolism*; D015313:Cefotetan / Q000493:pharmacokinetics*; D003106:Colon / Q000378:metabolism / Q000601:surgery; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000601:surgery; D012867:Skin / Q000378:metabolism; D013396:Suction; D014018:Tissue Distribution
D015313:Cefotetan