title: Relative and combined effects of ethanol and protein deficiency on gonadal function and histology.
abstract: The aim of the present study is to analyse the relative and combined effects of ethanol and protein deficiency on serum testosterone and LH, and on gonadal histology, in ethanol fed rats. The study was performed in 32 animals divided into four groups, fed with the Lieber & DeCarli control, 36% ethanol, 2% protein, and 36% ethanol 2% protein containing diets, respectively. Two months later, rats were anaesthetized with pentobarbital and sacrificed, and the right testes and epididymus were carefully removed. Both ethanol and protein deficiency independently lead to a decrease in serum testosterone levels, and to testicular atrophy, lowest testosterone levels and highest degrees of atrophy being observed in the rats receiving the 36% ethanol, 2% protein containing diet. Both serum testosterone and testicular size and weight significantly correlated with final weight and serum albumin. Hypospermia, atrophy of the seminiferous tubules, and reduced epididymal diameter were also observed in this last group of animals. Thus, protein deficiency may contribute to hypogonadism of alcoholics.
authors: Department of Medicina Interna, Facultad de Medicina, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
authors: E
authors: E
authors: Gonzalez-Reimers
authors: A
authors: A
authors: Martinez-Riera
authors: F
authors: F
authors: Santolaria-Fernandez
authors: A
authors: A
authors: Conde-Martel
authors: H
authors: H
authors: Alvarez-Argüelles
authors: C
authors: C
authors: Santana-Herrera
authors: F
authors: F
authors: Rodriguez-Moreno
mesh_terms: D000818:Animals; D001284:Atrophy; D004822:Epididymis / Q000473:pathology; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D011488:Protein Deficiency / Q000473:pathology* / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D013076:Sperm Count; D013737:Testis / Q000473:pathology* / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood
chemical_list: D012709:Serum Albumin; D000431:Ethanol; D013739:Testosterone; D007986:Luteinizing Hormone