Deficient repair of UV-induced DNA damage in immature human T cells.
As compared with quiescent lymphocytes, human thymocytes were found in the nucleoid sedimentation assay to be deficient in UV-induced DNA repair. Therefore, the age-related repair deficiency of human lymphocytes can result from the increased proportion of immature T cells occurring with age.
Hartwig
M
M
Max Delbrück Center for Molecular Medicine, Berlin.
D000293:Adolescent; D016922:Cellular Senescence / Q000528:radiation effects*; D002499:Centrifugation, Density Gradient; D002648:Child; D002675:Child, Preschool; D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D011829:Radiation Dosage; D013601:T-Lymphocytes / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*