Successful continuous treatment with all-trans retinoic acid for acute promyelocytic leukemia; secondary malignancy after the treatment of osteosarcoma.
We report a rare case of complete remission for 32 months with continuous treatment with all-trans retinoic acid (ATRA) alone in a patient with acute promyelocytic leukemia which developed as a second malignancy after the treatment of osteosarcoma after failure of conventional chemotherapy. The adverse effects of ATRA were apparently tolerable.
Mahmud
N
N
Second Department of Internal Medicine, Mie University School of Medicine, Tsu.
Tsukada
T
T
Taniguchi
M
M
Takahashi
T
T
Kihira
H
H
Sekine
T
T
Miwa
H
H
Kobayashi
T
T
Kita
K
K
Deguchi
K
K
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D005266:Femoral Neoplasms / Q000628:therapy*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D012516:Osteosarcoma / Q000628:therapy*; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*
D014212:Tretinoin