title: Mannose-binding protein gene polymorphism in systemic lupus erythematosus.
abstract: OBJECTIVE
  To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE).
  
  
  METHODS
  MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls.
  
  
  RESULTS
  The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3).
  
  
  CONCLUSIONS
  Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.
authors: Epidemiology Research Unit, University of Manchester, UK.
authors: E J
authors: EJ
authors: Davies
authors: N
authors: N
authors: Snowden
authors: M C
authors: MC
authors: Hillarby
authors: D
authors: D
authors: Carthy
authors: D M
authors: DM
authors: Grennan
authors: W
authors: W
authors: Thomson
authors: W E
authors: WE
authors: Ollier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D003165:Complement System Proteins / Q000172:deficiency; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D037241:Mannose-Binding Lectins; D008875:Middle Aged; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
chemical_list: D002352:Carrier Proteins; D037241:Mannose-Binding Lectins; D003165:Complement System Proteins