title: Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.
abstract: We report the characterization of a member of the ras gene family that is overexpressed in cells transformed by abl tyrosine kinase oncogenes. The gene, named kir (for kinase-inducible ras-like), is induced at the transcriptional level. kir mRNA has a rapid turnover and encodes a protein of 33 kDa with guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. kir was cloned by differential screening of genes present in fully malignant versus growth factor-independent cell lines expressing wild-type or mutant forms of BCR/ABL. BCR/ABL and v-Abl induce transcription of the kir gene via specific signaling pathway(s), but kir overexpression alone is not sufficient to mediate transformation.
authors: Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024-1662.
authors: L
authors: L
authors: Cohen
authors: R
authors: R
authors: Mohr
authors: Y Y
authors: YY
authors: Chen
authors: M
authors: M
authors: Huang
authors: R
authors: R
authors: Kato
authors: D
authors: D
authors: Dorin
authors: F
authors: F
authors: Tamanoi
authors: A
authors: A
authors: Goga
authors: D
authors: D
authors: Afar
authors: N
authors: N
authors: Rosenberg
mesh_terms: D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D002471:Cell Transformation, Neoplastic; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D017874:Immediate-Early Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D020559:Monomeric GTP-Binding Proteins; D016374:Oncogene Proteins v-abl / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D018076:DNA, Complementary; D017874:Immediate-Early Proteins; D016374:Oncogene Proteins v-abl; D012333:RNA, Messenger; D011505:Protein-Tyrosine Kinases; D016044:Fusion Proteins, bcr-abl; D019204:GTP-Binding Proteins; C088119:Gem protein, mouse; D020559:Monomeric GTP-Binding Proteins