Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation.
Welton
A F
AF
Department of Bronchopulmonary Research, Roche Research Center, Nutley, New Jersey 07110.
O'Donnell
M
M
Renzetti
L
L
Simko
B
B
Tocker
J
J
Cashin
C
C
Newbold
P
P
Wasserman
M A
MA
D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects; D006168:Guinea Pigs; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010617:Phenanthridines / Q000494:pharmacology* / Q000627:therapeutic use; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011014:Pneumonia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D013189:SRS-A / Q000037:antagonists & inhibitors*; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use
D010617:Phenanthridines; D010972:Platelet Activating Factor; D013189:SRS-A; D013844:Thiazoles; D014227:Triazines; C071318:Ro 24-4736; C071436:cinalukast