title: Primary plasma cell leukaemia.
abstract: Among 750 previously untreated patients with multiple myeloma, 27 (4%) presented with plasma cell leukaemia. All but one patient had high tumour mass and, when compared with comparable patients without leukaemia, more frequent extraosseous involvement, thrombocytopenia, high serum lactate dehydrogenase and hypodiploid plasma cells. Most patients also had complex cytogenetic abnormalities. Treatment with standard melphalan-prednisone was ineffective, with a median survival of 2 months, but more intensive chemotherapy induced responses in approximately one-half of the patients, with a median survival of 20 months. Primary plasma cell leukaemia usually results from the proliferation and extramedullary expansion of immature plasma cells and requires prompt and intensive chemotherapy.
authors: University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors: M A
authors: MA
authors: Dimopoulos
authors: A
authors: A
authors: Palumbo
authors: K B
authors: KB
authors: Delasalle
authors: R
authors: R
authors: Alexanian
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007952:Leukemia, Plasma Cell / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000401:mortality / Q000473:pathology; D016609:Neoplasms, Second Primary; D010950:Plasma Cells / Q000473:pathology; D016019:Survival Analysis; D016896:Treatment Outcome; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D001613:beta 2-Microglobulin; D007770:L-Lactate Dehydrogenase