Effect of zimeldine and its metabolites on [3H]thymidine incorporation in lymphocyte cultures from psychiatric patients with or without a hypersensitivity reaction during zimeldine therapy.
Lymphocyte transformation test (LTT) was applied to 28 patients who had developed a hypersensitivity syndrome (HSS) during treatment with the antidepressant drug zimeldine. Twenty-seven patients treated with zimeldine without any symptom of an HSS were matched controls. Zimeldine and its metabolites norzimeldine and CPP 200 all induced statistically significant increased [3H]thymidine incorporation in cultured lymphocytes from the HSS patients compared with the controls, norzimeldine being the most potent inducer. The results indicate an immunoreactive process in the development of the HSS induced by zimeldine.
Kristofferson
A
A
Astra Research Centre, Södertälje, Sweden.
Sohl-Akerlund
A
A
Hall
E
E
Bengtsson
B O
BO
Ogenstad
S
S
Wålinder
J
J
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008875:Middle Aged; D013936:Thymidine / Q000378:metabolism*; D015031:Zimeldine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000276:immunology / Q000627:therapeutic use
D000928:Antidepressive Agents; D015031:Zimeldine; C017578:norzimelidine; D013936:Thymidine