Breast cancer in first degree relatives of 180 female breast cancer patients.
The risk of breast cancer and of all malignancies was assessed in first degree relatives of 180 women with breast cancer using a historical cohort study approach. The standardized incidence ratio (SIR) was significantly (p < 0.05) increased for breast cancer in mothers: 1.97 (95% Confidence Interval (CI): 1.27 to 2.91) and in all female first degree relatives: 1.55 (95% CI: 1.08 to 2.15). For breast cancer in sisters it was 1.12 (95% CI: 0.56 to 2.01). For all malignancies the SIR for mothers was 1.12 (95% CI: 0.85 to 1.44), for sisters 1.09 (95% CI: 0.77 to 1.49) and for all female first degree relatives 1.08 (95% CI: 0.89 to 1.32). This study confirms previous investigations showing that breast cancer occurs more frequently in female first degree relatives of women with breast cancer than in the general population.
Fürstenberger
G
G
Computing Department, University of Basel, Switzerland.
Christen
H
H
Minder
C E
CE
Spycher
M
M
Weber
W
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors; D013557:Switzerland / Q000453:epidemiology