title: Regulation of mouse UBF gene by multiple growth-related control elements.
abstract: Transcription of the mouse Upstream Binding Factor (mUBF) gene, that encodes one of the essential transcription factors for ribosomal DNA transcription, starts from several nucleotides. Neither typical TATA-box nor CCAAT-box is found upstream of the transcription initiation site. In the promoter region, there are eight GC-boxes, eight AP-2 binding consensus sequences, four cAMP response elements, and several serum response element equivalent sequences. These elements appear to play a positive role for the regulation of the mUBF gene as a whole. Among serum response elements, members located between -1182 and -343 are indeed responsive to serum, suggesting their important role in the high expression of mUBF under cell growth conditions.
authors: Department of Biochemistry, University of Tokyo Faculty of Medicine, Japan.
authors: T
authors: T
authors: Nishimura
authors: K
authors: K
authors: Hanada
authors: Y
authors: Y
authors: Maeda
authors: C Z
authors: CZ
authors: Song
authors: K
authors: K
authors: Hisatake
authors: M
authors: M
authors: Muramatsu
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D015500:Chloramphenicol O-Acetyltransferase / Q000096:biosynthesis; D002522:Chlorocebus aethiops; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D005786:Gene Expression Regulation; D007700:Kinetics; D051379:Mice / Q000235:genetics*; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D035463:Pol1 Transcription Initiation Complex Proteins; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis / Q000302:isolation & purification; D011994:Recombinant Proteins / Q000096:biosynthesis; D015183:Restriction Mapping; D016385:TATA Box; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D014158:Transcription, Genetic; D014162:Transfection
chemical_list: D017931:DNA Primers; D004268:DNA-Binding Proteins; D035463:Pol1 Transcription Initiation Complex Proteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D014157:Transcription Factors; C063844:transcription factor UBF; D015500:Chloramphenicol O-Acetyltransferase