Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by dinitrofluorobenzene.
The effects of a topical preparation of mycophenolic acid on the experimental allergic contact dermatitis induced by dinitrofluorobenzene was investigated. Visual assessment of skin reactions showed significant efficacy of a topical preparation of mycophenolic acid. This efficacy appeared from the early stage and endured up to 3 days. Morphological changes in the epidermis and dermis layers of animals treated with a mycophenolic acid cream were moderate compared with that in animals treated with vehicle only. In particular, hyperkeratosis was strongly suppressed. Since suppression of inflammatory cell infiltration was also observed, this efficacy might reach to the epidermis and dermis layer.
Shoji
Y
Y
Department of Clinical Pharmacology, St Marianna University School of Medicine, Kawasaki, Japan.
Fukumura
T
T
Kudo
M
M
Yanagawa
A
A
Shimada
J
J
Mizushima
Y
Y
D000287:Administration, Topical; D000818:Animals; D002070:Butadienes / Q000737:chemistry; D003652:Decanoic Acids / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy*; D004139:Dinitrofluorobenzene / Q000633:toxicity; D004195:Disease Models, Animal; D004817:Epidermis / Q000187:drug effects / Q000473:pathology; D000431:Ethanol / Q000737:chemistry; D005233:Fatty Alcohols / Q000737:chemistry; D005260:Female; D006168:Guinea Pigs; D045782:Hemiterpenes; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009226:Myristates / Q000737:chemistry; D009227:Myristic Acids / Q000737:chemistry; D010168:Palmitates / Q000737:chemistry; D016612:Paraffin Embedding; D010420:Pentanes; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers; D012867:Skin / Q000187:drug effects*; D013229:Stearic Acids / Q000737:chemistry
D002070:Butadienes; D003652:Decanoic Acids; D005233:Fatty Alcohols; D045782:Hemiterpenes; D009226:Myristates; D009227:Myristic Acids; D010168:Palmitates; D010420:Pentanes; D011108:Polymers; D013229:Stearic Acids; C005059:isoprene; C008205:isopropyl myristate; D000431:Ethanol; D011092:Polyethylene Glycols; C031183:stearic acid; C006957:cetyl palmitate; C005031:cetyl alcohol; D004139:Dinitrofluorobenzene; D009173:Mycophenolic Acid; C029410:ethyl sebacate