Monitoring of neuromuscular function in the clinical setting.
This paper will review the basics of neurostimulation in the perioperative period. Following a brief overview of neuromuscular physiology, the mechanism of action of depolarizing and non-depolarizing relaxants will be discussed. The principles of neurostimulation will then be applied clinically when different patterns of stimulation (single twitch, train-of-four, post-tetanic twitch count, double burst) are described. Clinical assessment of neuromuscular function will then be compared with both subjective and objective means of assessment of adequacy of intraoperative relaxation and postoperative reversal. The principles reviewed in this paper will then be applied in the clinical setting, and risks and benefits associated with perioperative use of muscle relaxants will be discussed.
Kelly
D
D
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut.
Brull
S J
SJ
D006801:Humans; D007430:Intraoperative Care; D008991:Monitoring, Physiologic; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D011182:Postoperative Care; D011300:Preoperative Care
D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents