A complete hydatidiform mole coexisting with a normal fetus was confirmed by variable number tandem repeat (VNTR) polymorphism analysis using polymerase chain reaction.
The diagnosis of a complete hydatidiform mole coexisting with a live fetus is often difficult because of the morphological similarity to a partial mole, but it is crucial to management in the postmolar course. We present a recent case in which DNA polymorphism analysis clearly revealed a different genetic origin for the fetal and molar parts. DNA polymorphisms on three different variable number tandem repeat loci, which were detected by polymerase chain reaction, indicated that the cord/placenta and molar tissue were parental and androgenetic, respectively. Subsequently, the patient was admitted for chemotherapy of metastatic trophoblastic disease.
Osada
H
H
Department of Obstetrics and Gynecology, Chiba University School of Medicine, Japan.
Iitsuka
Y
Y
Matsui
H
H
Sekiya
S
S
D000328:Adult; D004247:DNA / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005313:Fetal Death / Q000235:genetics; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics*; D018598:Minisatellite Repeats; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011247:Pregnancy; D018245:Trophoblastic Tumor, Placental Site / Q000235:genetics*; D014429:Twins, Dizygotic / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm; D004247:DNA