[Effect of sodium nucleinate on ventricular arrhythmia and blood level of medium molecular weight peptides in an experiment].
The experiments on 18 isolated albino rat hearts have shown that sodium nucleinate exerts a protective action on the occurrence of reperfusion ventricular arrhythmias. Sodium nucleinate was given orally in a daily dose of 50/kg for 2 weeks. The agent reduced the blood concentrations of medium-weight molecular peptides, which may be regarded as the liquidation of a factor predisposing to arrhythmias. Other possible mechanisms responsible for the antiarrhythmic activity of sodium nucleinate, which are adaptable to the immunomodulating and membranoprotective properties of the drug, as well as to its ability to enhance intracellular metabolism are also discussed in the paper.
Zemskov
V M
VM
Nikitin
A V
AV
Zemskov
A M
AM
Alabovskiĭ
V V
VV
Gusmanov
V A
VA
Trunov
B N
BN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000517:prevention & control*; D066298:In Vitro Techniques; D008970:Molecular Weight; D009696:Nucleic Acids / Q000494:pharmacology*; D010455:Peptides / Q000097:blood*; D051381:Rats; D015427:Reperfusion Injury / Q000097:blood / Q000517:prevention & control*; D018754:Ventricular Dysfunction / Q000097:blood / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; D010455:Peptides; C013683:sodium nucleinate
Vliianie nukleinata natriia na zheludochkovye aritmii i uroven' srednemolekuliarnykh peptidov krovi v éksperimente.