Inhibition of the A1 area prevents hemorrhage-induced secretion of vasopressin in rats.
In rats, secretion of vasopressin initiated by hemorrhage was completely abolished after muscimol-induced inhibition of neuronal function in the A1 region of the ventrolateral medulla oblongata. The A1 neurons are essential links in the central pathway to hypothalamic vasopressin-synthesizing neurons in this species.
Gieroba
Z J
ZJ
Department of Medicine and Physiology, Flinders Medical Centre for Neuroscience, Flinders University, Bedford Park, Australia.
Shapoval
L N
LN
Blessing
W W
WW
D000818:Animals; D006470:Hemorrhage / Q000503:physiopathology*; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology / Q000187:drug effects*; D008845:Microinjections; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins; D009118:Muscimol