Role of low-density lipoproteins in atherogenesis and development of coronary heart disease.
There is a strong association between increased blood concentrations of low-density lipoprotein (LDL) and severity of coronary atherosclerosis. Multiple mechanisms affect hypercholesterolemia, e.g., diet, aging, hormones, and genetics. LDL receptors apparently are also important--through down-regulation, defects in structure, or decreased numbers--as are changes in LDL binding characteristics caused by alterations in apolipoprotein B content or structure. Current concepts of LDL metabolism are extensively reviewed, including the role of modified or oxidized LDL in atherogenesis.
Grundy
S M
SM
Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas 75235-9052.
D001161:Arteriosclerosis / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D012307:Risk Factors
D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL