title: Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains.
abstract: By employing multiprobe oligonucleotide solution hybridisation (MOSH) we have measured the levels of mRNA encoding the NMDA receptor subtypes (R1, R2A, R2B and R2C) and the non-NMDA glutamate receptor subtypes (GluR1, 2, 3, and 4) within rat brain following, 1-32 days of antipsychotic or antidepressant drug administration. The results suggest that the drugs studied do not significantly alter rat glutamatergic system mRNA levels when compared to controls.
authors: Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
authors: R G
authors: RG
authors: Oretti
authors: G
authors: G
authors: Spurlock
authors: P R
authors: PR
authors: Buckland
authors: P
authors: P
authors: McGuffin
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001483:Base Sequence; D001923:Brain Chemistry / Q000187:drug effects*; D015283:Citalopram / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics; D012559:Schizophrenia; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D015283:Citalopram; D008803:Mianserin; D013469:Sulpiride; D003024:Clozapine; D006220:Haloperidol