Comparison of the renal effects of urodilatin and atrial natriuretic factor: effect of changes in sodium status.
Urodilatin is an amino terminally extended form of atrial natriuretic factor (ANF) which is resistant to enzymatic cleavage by renal neutral endopeptidase (NEP: EC 3.4.24.11). The renal effects of infusion into the renal artery of equimolar doses of urodilatin or ANF have been compared following changes in Na status in conscious sheep. In all conditions urodilatin was a more potent natriuretic stimulus than was ANF and the natriuretic response to urodilatin was modulated by sodium status in the same way as the response to ANF: diminished by sodium depletion and enhanced by sodium loading. This study does not support the hypothesis that changes in NEP activity contribute to the modulation of the natriuretic response to ANF which is observed with modification of sodium status.
Yates
N A
NA
Howard Florey Institute, University of Melbourne, Parkville, Vic., Australia.
McDougall
J G
JG
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology*; D012756:Sheep; D012964:Sodium / Q000378:metabolism* / Q000652:urine
D004232:Diuretics; D010446:Peptide Fragments; C056452:Ularitide; D009320:Atrial Natriuretic Factor; D012964:Sodium