[Nuclear proteins of human leukocytes in health and in chronic leukemias].
The levels and fractional composition of nuclear proteins of human leukocytes (histones, total non-histone proteins and HMG-proteins) have been studied in healthy subjects and cases of leukemia. It has been shown that the levels of histones and total non-histone proteins in normal myeloid cells are, on the average, 1.5 times those in lymphoid cells. Leukemia has been shown to involve elevated concentrations of high-molecular components in the histone and HMG-protein fraction of white blood cells as well as a slight decrease in both high- and low-molecular components in the fraction of total non-histone proteins. This points to disturbances in the epigenomic regulation of the genome involved in leukemia.
Rybakova
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LP
D006098:Granulocytes / Q000378:metabolism; D006609:High Mobility Group Proteins / Q000097:blood; D006657:Histones / Q000097:blood; D006801:Humans; D007938:Leukemia / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood; D007962:Leukocytes / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D009363:Neoplasm Proteins / Q000097:blood*; D009687:Nuclear Proteins / Q000097:blood*
D006609:High Mobility Group Proteins; D006657:Histones; D009363:Neoplasm Proteins; D009687:Nuclear Proteins
Iadernye belki leĭkotsitov cheloveka v norme i pri khronicheskikh leĭkozakh.