Stability of amoxycillin and potassium clavulanate in co-amoxiclav oral suspension.
A study was carried out using high performance liquid chromatography (HPLC) to determine the chemical stability of amoxycillin and potassium clavulanate in 250/62 co-amoxyclav oral suspension (Augmentin), stored at room temperature (RT, 20 degrees C) and 8 degrees C over a period of 11 days. The suspension was judged to be acceptable if its components maintained at least 90% of their label concentrations. During the test period, the amoxycillin component was found to be more stable than the clavulanate. Amoxycillin was stable for 7 days at both temperatures. Potassium clavulanate maintained at least 90% of its initial concentration for 7 days at 8 degrees C but showed more than 40% degradation in the same time period at RT. For potassium clavulate the shelf-life, or time taken for the original concentration to drop to 90% of its value (t90) at RT was found to be 2 days.
Mehta
A C
AC
Department of Pharmacy, General Infirmary, Leeds, U.K.
Hart-Davies
S
S
Payne
J
J
Lacey
R W
RW
D000658:Amoxicillin; D019980:Amoxicillin-Potassium Clavulanate Combination; D002851:Chromatography, High Pressure Liquid; D002969:Clavulanic Acids; D004355:Drug Stability; D004359:Drug Therapy, Combination; D013535:Suspensions; D013696:Temperature
D002969:Clavulanic Acids; D013535:Suspensions; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin