title: Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimization procedure.
abstract: Quantitative analysis of Gd-DTPA enhanced dynamic MR images has potential for discriminating lesions, especially because the introduction of clinical fast imaging techniques has enabled good sampling of the relatively rapid Gd-DTPA wash-in curves. Analysis of such data requires curve fitting to a nonlinear model, which to date has been performed using a nonlinear least squares (NLLS) fitting procedure. However, this method often fails to converge to the appropriate minima without good initial parameter estimates when multi-exponential models are involved, making automated analysis of complete multislice or volume data sets problematic. In this report we demonstrate the robust performance of a simplex minimization procedure compared with NLLS, by the method of Marquardt, using a Monte Carlo simulation. Further, we illustrate the applicability of such a technique to the analysis of dynamic contrast enhanced images on a pixel-by-pixel basis. As a preliminary example, the technique is applied to a breast lesion but is expected to be suitable for examination of many lesion types.
authors: Centre for MR Investigations, Hull Royal Infirmary, United Kingdom.
authors: D L
authors: DL
authors: Buckley
authors: R W
authors: RW
authors: Kerslake
authors: S J
authors: SJ
authors: Blackband
authors: A
authors: A
authors: Horsman
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D003198:Computer Simulation; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D009361:Neoplasm Invasiveness; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D012815:Signal Processing, Computer-Assisted
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA