[Cyclosporin in the treatment of idiopathic aplastic anemia].
Five patients with aplastic anemia were treated with cyclosporine A. In four cases a positive response was noted. In three out of these patients frequency of blood transfusions was decreased. Platelet count increased to 50 x 10(9)/L in two cases and in one case agranulocytosis disappeared. Synergistic effect of cyclosporine A with oxymetholone and prednisone was seen. In one case an improvement lasted only for 1 year. Hepatotoxicity being a complication of therapy was noted in one patient.
Kopeć
I
I
Konopka
L
L
Słomkowski
M
M
Maj
S
S
D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010110:Oxymetholone / Q000494:pharmacology; D010976:Platelet Count; D011241:Prednisone / Q000494:pharmacology; D016896:Treatment Outcome
D016572:Cyclosporine; D010110:Oxymetholone; D011241:Prednisone
Cyklosporyna w leczeniu samoistnej niedokrwistości aplastycznej.