title: [The effect of nimodipine on cochlear blood flow in the guinea pig].
abstract: The influence of nimodipine (Nimotop, CAS 66085-59-4), a selectively cerebrovascularly acting 1,4-dihydropyridine calcium antagonist, on the cochlear blood flow (CBF) was studied in 19 guinea pigs (6 controls). The hydrogen clearance measurements were carried out under alpha-chloralose-ethylurethane anaesthesia, artificial respiration with simultaneous control of electrocardiogram, blood pressure, body temperature and arterial pH (hourly). The indirect measurement of CBF was carried out by means of hydrogen clearance in the perilymphatic space (basal turn) before and after intravenous application of 1 microgram nimodipine/kg/min. The mean arterial blood pressure remained within the +/- 5% range of the initial value during the experiment. Under treatment with nimodipine the CBF showed a non-significant average increase of 4.69% and under placebo (20% ethanol, 17% polyethylenglycol 400, citrate buffer), a non-significant average decrease of 6.16%. The influence of nimodipine on CBF was underlined by the overcompensation of the placebo effect.
authors: Ernst-Moritz-Arndt-Universität Greifswald, Klinik für Hals-Nasen-Ohrenkrankheiten.
authors: P
authors: P
authors: Meyer
authors: E
authors: E
authors: Werner
authors: R
authors: R
authors: Schmidt
authors: W
authors: W
authors: Grützmacher
authors: W
authors: W
authors: Gehrig
authors: F
authors: F
authors: Seuter
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003051:Cochlea / Q000098:blood supply* / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D006168:Guinea Pigs; D009553:Nimodipine / Q000493:pharmacokinetics / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D009553:Nimodipine
vernacular_title: Beeinflussung der kochleären Durchblutung des Meerschweinchens durch Nimodipin.