title: Induction of Fos-like immunoreactivity in rat oxytocin neurons following insulin injections.
abstract: Double immunostaining for oxytocin (OT) and Fos was used to study the oxytocinergic system of the rat hypothalamic paraventricular nucleus (PVN) following intraperitoneal insulin injections. The expression of c-fos in the PVN appeared about 3 h after insulin treatment and was very high after 5 h while no labelling was observed in isotonic saline-injected animals. Twelve to 18% of OT neurons expressed Fos-like immunoreactivity and these activated neurons were found in both the magno- and the parvocellular compartments of the PVN suggesting that the OT neuron responses to insulin induced disturbances are complex and involve hormonal as well as autonomic pathways.
authors: CNRS URA 561, Faculté de Médecine, Besançon, France.
authors: B
authors: B
authors: Griffond
authors: A
authors: A
authors: Deray
authors: M
authors: M
authors: Bahjaoui-Bouhaddi
authors: C
authors: C
authors: Colard
authors: C
authors: C
authors: Bugnon
authors: D
authors: D
authors: Fellmann
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010121:Oxytocin / Q000032:analysis / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D007328:Insulin; D016760:Proto-Oncogene Proteins c-fos; D010121:Oxytocin