title: Identification of an activator of the retinoid X receptor.
abstract: A metabolite of all-trans retinoic acid produced by insect cells was discovered to activate the intracellular retinoic acid X receptor. The compound, beta-glucopyranosyl 9-cis-retinoate [1], was purified and its structure was determined by analysis of spectroscopic data.
authors: Ligand Pharmaceuticals Inc., San Diego, California 92121.
authors: C
authors: C
authors: Pathirana
authors: R A
authors: RA
authors: Heyman
authors: S B
authors: SB
authors: Lazarchik
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002478:Cells, Cultured; D004331:Drosophila melanogaster / Q000737:chemistry*; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D018168:Receptors, Retinoic Acid / Q000187:drug effects*; D047488:Retinoid X Receptors; D017550:Spectroscopy, Fourier Transform Infrared; D014157:Transcription Factors / Q000187:drug effects*; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D005960:Glucosides; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D014157:Transcription Factors; D014212:Tretinoin; C091309:glucopyranosyl retinoate