title: Effects of prostaglandin F2 alpha (PGF2 alpha) on secretion of estradiol-17 beta and cortisol in 90 to 100 day hysterectomized, intact and ovariectomized pregnant ewes.
abstract: Vehicle or 8 or 16 mg PGF2 alpha/58 kg/body weight (BW) was given intramuscularly to intact, hysterectomized and ovariectomized 90 to 100 day pregnant ewes in three separate experiments. Hysterectomy alone decreased (P < or = 0.05) estradiol-17 beta in jugular venous blood by 80 percent within 16 hours and profiles of estradiol-17 beta did not differ (P > or = 0.05) among vehicle or 8 or 16 mg PGF2 alpha/58 kg/BW-treated ewes. Profiles of estradiol-17 beta differed (P < or = 0.05) in intact pregnant ewes treated with 8 or 16 mg PGF2 alpha/58 kg/BW when compared to controls and in ovariectomized (P < or = 0.10) 90 to 100 day pregnant ewes treated with 16 mg PGF2/58 kg/BW. Estradiol-17 beta decreased (P < or = 0.05) over time in vehicle and 8 mg PGF2 alpha/58 kg/BW-treated intact and in vehicle-treated ovariectomized 90 to 100 day pregnant ewes. Cortisol decreased (P < or = 0.05) over time in hysterectomized, intact, and ovariectomized 90 to 100 days pregnant ewes, but did not differ (P < or = 0.05) among vehicle or 8 or 16 mg PGF2 alpha/58 kg/BW-treated ewes. It is suggested that estradiol-17 beta has a role in regulating ovine placental steroidogenesis.
authors: Department of Animal Sciences, University of Hawaii, Honolulu, 96822.
authors: Y S
authors: YS
authors: Weems
authors: D L
authors: DL
authors: Vincent
authors: K D
authors: KD
authors: Nusser
authors: Y
authors: Y
authors: Tanaka
authors: K
authors: K
authors: Miller-Patrick
authors: K S
authors: KS
authors: Ledgerwood
authors: C W
authors: CW
authors: Weems
mesh_terms: D000818:Animals; D015237:Dinoprost / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D005260:Female; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007044:Hysterectomy; D010052:Ovariectomy; D011247:Pregnancy; D012756:Sheep
chemical_list: D004958:Estradiol; D015237:Dinoprost; D006854:Hydrocortisone