Reactivation of antibodies of donor and recipient origin to platelet antigens early after allogeneic bone marrow transplantation: a case report.
Reactivation of platelet-reactive antibodies of donor and recipient origin is described in a patient following allogeneic BMT (donor: anti-HPA-5b; recipient: anti-HLA, anti-HPA-1b). The antibodies were detected around day 15 after BMT, peaked around day 25, and then decreased. These antibodies are interpreted as an antigen-independent reactivation of secondary B-cell responses, activated in the context of recognition of host antigens by the graft.
Wernet
D
D
Department of Transfusion Medicine, University Hospital, Tübingen, Germany.
Northoff
H
H
Schnaidt
M
M
D000328:Adult; D000937:Antigen-Antibody Reactions; D016824:Antigens, Human Platelet / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D012189:Retrospective Studies; D014184:Transplantation, Homologous
D016824:Antigens, Human Platelet; D006680:HLA Antigens