Dopamine does not mediate protein-induced hyperfiltration.
Dopamine and a meat meal have both been used to stimulated hyperfiltration. Urinary dopamine has been said to rise after a meal. It has been suggested that the responses are the same. In order to clarify this relationship, the DOPA decarboxylase inhibitor carbidopa was used to abolish dopamine synthesis during a meat meal. Eight normal individuals were studied twice. On each occasion they ate a meat meal and resting and post-prandial haemodynamics were measured. On 1 of the 2 study days they received carbidopa which abolished renal dopamine synthesis. Despite this there was no change in resting haemodynamics and the meat meal response was preserved. We conclude that urinary dopamine does not rise after a meal and that dopamine does not mediate the meat meal response.
Thomas
D M
DM
Institute of Nephrology, Cardiff Royal Infirmary, UK.
Coles
G A
GA
Williams
J D
JD
D002230:Carbidopa / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology* / Q000652:urine; D004435:Eating / Q000502:physiology*; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology; D011506:Proteins / Q000494:pharmacology*
D011506:Proteins; D002230:Carbidopa; D004298:Dopamine