title: Bistramides A, B, C, D, and K: a new class of bioactive cyclic polyethers from Lissoclinum bistratum.
abstract: The isolation and characterization is described of four novel cyclic polyethers, bistramides B [2], C [3], D [4], and K [5], which are closely related to the previously reported bistramide A [1] from the New Caledonian urochordata Lissoclinum bistratum. The structures of these metabolites were defined by spectroscopic methods. The four compounds exhibited in vitro cytotoxicity toward six tumor cell lines, including the human non-small cell lung carcinoma (NSCLC-N6) line. Cytofluorimetric analysis with bistramide K showed a complete block of NSCLC-N6 cells in the G1 phase. Bistramide D and particularly bistramide K are less toxic than bistramides A, B, and C and are thereby effective in vivo against NSCLC-N6.
authors: Institut Substances et Organismes de la Mer (ISOMER), Faculté de Pharmacie, Université de Nantes, France.
authors: J F
authors: JF
authors: Biard
authors: C
authors: C
authors: Roussakis
authors: J M
authors: JM
authors: Kornprobst
authors: D
authors: D
authors: Gouiffes-Barbin
authors: J F
authors: JF
authors: Verbist
authors: P
authors: P
authors: Cotelle
authors: M P
authors: MP
authors: Foster
authors: C M
authors: CM
authors: Ireland
authors: C
authors: C
authors: Debitus
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology; D002470:Cell Survival; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004988:Ethers, Cyclic