Further studies on the occurrence of serum autoantibodies against a membrane bound AChE fraction in ALS/MND patients and controls.
Autoantibodies of the IgG and IgA types against a membrane bound AChE fraction were studied in the serum of ALS/MND patients, controls with neurological or autoimmune diseases, and normal controls. About 70% of ALS and progressive spinal muscle atrophy (PMA) patients had antibodies of both Ig types (titre > 1/81), compared to about 12% of neurologically diseased controls and about 8% of the other controls. A higher proportion of individuals having autoantibodies was found in the older age group in both patients and controls.
Conradi
S
S
Department of Neurology, Karolinska Hospital, Stockholm, Sweden.
Ronnevi
L O
LO
D000110:Acetylcholinesterase / Q000276:immunology*; D000368:Aged; D000375:Aging / Q000276:immunology; D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D002462:Cell Membrane / Q000201:enzymology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000201:enzymology / Q000276:immunology*
D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D000110:Acetylcholinesterase