[Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman].
We report a woman with insulin resistance associated with hyperandrogenism and acanthosis nigricans (HAIR-AN syndrome) treated during 30 days with the prolonged action opioid antagonist Naltrexone. During its administration, decreases in basal blood glucose and serum insulin, insulin and glucose response to a glucose load and plasma testosterone were observed. These findings suggest that opioid activity could play a critical role in the physiopathology of hyperinsulinemia in hyperandrogenic women.
Sir
T
T
Unidad de Endocrinología, Facultad de Medicina (Campus Occidente), Hospital San Juan de Dios.
López
G
G
Alba
F
F
Cipriano
A
A
Candía
M
M
Castillo
T
T
Devoto
L
L
D000052:Acanthosis Nigricans / Q000097:blood / Q000188:drug therapy*; D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D009271:Naltrexone / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D001786:Blood Glucose; D006062:Gonadotropins; D007328:Insulin; D013739:Testosterone; D009271:Naltrexone
Efecto del bloqueo crónico del receptor opioidergico sobre la insulino-resistencia en una mujer hiperandrogénica.