title: Indirect myocardial revascularization--an experimental study in the dog.
abstract: It has been shown in previous studies that grafting a free skeletal muscle flap onto the heart of the dog produces myocardial revascularization. In order to evaluate the functional aspect of these neovessels, an Ameroid constrictor was implanted into the LADs (left anterior descending coronary artery) of five dogs. At the same time, the free muscle flap was grafted onto the anterior wall of the heart. The arterial anastomosis was achieved with the internal mammary artery. Venous flow was drained into the right atrium. About 12 months later, the regional myocardial blood flow was evaluated adopting the radioactive microsphere technique. This was carried out with the LAD occluded by the Ameroid constrictor and the circumflex artery (CX) open (control conditions). Then the CX was occluded in order to exclude collateral blood flow. Afterwards another occlusion of the CX was performed ("preconditioning") to produce maximal opening of the anatomical collaterals. It was found that regional myocardial blood flow was unchanged in the antero-lateral parts of the hearts despite complete occlusion of the coronaries supplying this area. In the parts supplied by the CX, though, flow was minimal. "Preconditioning" positively influenced the perfusion of this region only in the epicardial parts. Histologically large sinusoid-like blood conductors connected the graft and the heart. Thus, grafting a free skeletal muscle flap onto the heart in the dog produces functional myocardial revascularization in the dog.
authors: Department of Cardiac Surgery, University of Ulm Hospital, Germany.
authors: M
authors: M
authors: Beyer
authors: U
authors: U
authors: Beyer
authors: S
authors: S
authors: Mierdl
authors: J
authors: J
authors: Sirch
authors: H
authors: H
authors: von Behren
authors: A
authors: A
authors: Hannekum
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D003097:Collateral Circulation; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000601:surgery; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D008297:Male; D008323:Mammary Arteries / Q000601:surgery; D009204:Myocardial Revascularization / Q000379:methods*; D013524:Surgical Flaps