Severe granular dystrophy: a pedigree with presumed homozygotes.
Three siblings with severe granular corneal dystrophy are described. They are most likely to be homozygous for the dominantly inherited gene. They are offspring of a consanguineous marriage, with both parents affected with corneal dystrophies. The case reports describe the severe course of this condition, requiring multiple grafting procedures. Clinical pictures of the family are shown.
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D000293:Adolescent; D001766:Blindness / Q000209:etiology; D002648:Child; D003317:Corneal Dystrophies, Hereditary / Q000150:complications / Q000235:genetics* / Q000601:surgery; D016039:Corneal Transplantation; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012008:Recurrence; D014792:Visual Acuity