Differential effects of chronic antidepressant treatment on 5-HT1C receptor binding sites in Wistar rat brain.
The effects of chronic clomipramine, imipramine and clorgyline on 5-HT1C receptors were studied in discrete brain regions, in male Wistar rats, using [3H]mesulergine to label the receptor binding sites. Clorgyline treatment significantly reduced [3H]mesulergine binding (Bmax values) in both the hypothalamus and striatum compared to saline-treated animals. There were no differences in the maximum number of [3H]mesulergine binding sites following clorgyline in the hippocampus, frontal cortex or brainstem. Neither clomipramine or imipramine treatment resulted in any significant changes in 5-HT1C receptor number in the brain regions examined here. Furthermore, the Kd values (receptor affinity) for [3H]mesulergine binding were not significantly different comparing treatment groups to control animals. The significant changes in discrete brain regions following chlorgyline treatment suggest that 5-HT1C receptors may be involved in the clinical efficacy for the treatment of depression and other neuropsychiatric disorders.
Hulihan-Giblin
B A
BA
Section on Neurochemistry and Neuroendocrinology, National Institute on Alcoholism and Alcohol Abuse, NIH Clinical Center, Bethesda, MD 20892.
Park
Y D
YD
Aulakh
C S
CS
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002997:Clomipramine / Q000494:pharmacology*; D003010:Clorgyline / Q000494:pharmacology*; D004873:Ergolines / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism
D004873:Ergolines; D011985:Receptors, Serotonin; D003010:Clorgyline; D002997:Clomipramine; D007099:Imipramine; C031649:mesulergine