title: A clinical and laboratory profile of symptomatic women with silicone breast implants.
abstract: One hundred seventy-six patients with breast prosthetic implants were evaluated. All women were symptomatic and were referred by either attorneys (152) or physicians (24) for rheumatic evaluation. The women ranged in age from 24 to 72 with a mean of 45 years. Indications for surgery were cosmetic (128), cancer (34), and other (14). Implants had been in place for 7 years or more in 120 patients and < 2 years in only 8. Eighty-three women required explantation of their original prostheses, and 63 had new implants inserted of which 47 were silicone and 16 were saline. Capsular contractures were present in 128 women, and documented implant rupture occurred in 67. Sixty-four women underwent manual closed capsulotomies. Of the 63 revisions, 37 resulted in contractures of the new implant. The most frequent symptoms seen in the women were chronic fatigue (77%) cognitive dysfunction (65%), arthralgia (56%), dry mouth (53%), dry eye (50%), alopecia (40%), and dysphagia (35%). The most common findings on physical examination were telangiectasias (60%), erythema of the chest wall (56%), carpal tunnel syndrome (47%), petechiae (46%), lacrimal gland enlargement (26%), thyroid tenderness (22%), thyroid enlargement (21%), and parotid enlargement (18%). Laboratory findings included elevated cholesterol (59%), elevated erythrocyte sedimentation rate (32%), elevated serum immunoglobulin (28%), and positive autonuclear antibody (25%) seen most often. Despite clinical features suggesting Sjögren's syndrome, antibodies to Ro (SSA) were seen in only 2 patients, and antibodies to La (SSB) were seen in only 4 patients. Siliconosis is a novel systemic disease with symptoms of chronic fatigue, cognitive dysfunction, sicca syndrome, and arthralgia.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Rheumatology and Molecular Medicine, Hospital For Joint Diseases Orthopaedic Institute, New York, NY 10003.
authors: G
authors: G
authors: Solomon
mesh_terms: D000328:Adult; D000368:Aged; D018427:Breast Implants / Q000009:adverse effects*; D003240:Connective Tissue Diseases / Q000175:diagnosis* / Q000209:etiology; D005221:Fatigue / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D016462:Mammaplasty; D008875:Middle Aged; D011183:Postoperative Complications; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000175:diagnosis / Q000209:etiology; D012828:Silicones / Q000009:adverse effects*; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000209:etiology; D013577:Syndrome
chemical_list: D012828:Silicones