title: Standardized microtiter assay for determination of syncytium-inducing phenotypes of clinical human immunodeficiency virus type 1 isolates.
abstract: A standardized assay in 96-well microtiter plates for syncytium-inducing (SI) human immunodeficiency virus type 1 phenotype detection using MT-2 cells has been developed. SI variants were found in 67% of the patients with advanced human immunodeficiency virus disease. The occurrence of the SI phenotype increased with lower CD4+ counts. There was no association between p24 antigenemia and the SI phenotype.
authors: Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215.
authors: A J
authors: AJ
authors: Japour
authors: S A
authors: SA
authors: Fiscus
authors: J M
authors: JM
authors: Arduino
authors: D L
authors: DL
authors: Mayers
authors: P S
authors: PS
authors: Reichelderfer
authors: D R
authors: DR
authors: Kuritzkes
mesh_terms: D001793:Blood Preservation; D018791:CD4 Lymphocyte Count; D002459:Cell Fusion; D015925:Cryopreservation; D003588:Cytopathogenic Effect, Viral; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D010641:Phenotype; D012015:Reference Standards; D014766:Viremia / Q000821:virology
chemical_list: D016655:HIV Core Protein p24