[Endogenous anti-analgesic systems].
Nociception is of vital importance for the organism, while its inhibition by endogenous opioid systems is usually a sign of surrender. Therefore, it must be assumed that endogenous analgesic systems are balanced, and in fact, under normal conditions, overwhelmed, by teleologically far more important anti-analgesic systems. The two main anti-analgesic systems--i.e., the melanotropinergic and the cholecystokininergic--are here reviewed for their role, not only in nociception, but in a wide variety of vital functions (endocrine, gastrointestinal, ingestive, reproductive, cardiovascular, immune, etc.). Available data strongly suggest that these systems (particularly the melanotropinergic one) play a key role in the overall homeostasis of the body. Moreover, modulation of endogenous anti-analgesic systems may disclose a new, unforeseen approach to the treatment of pain.
Bertolini
A
A
Dipartimento di Scienze Biomediche, Università degli Studi di Modena.
Poggioli
R
R
Bernardi
M
M
Genedani
S
S
Guarini
S
S
Bazzani
C
C
Arletti
R
R
Benelli
A
A
Bertolini
E
E
Balugani
A
A
D000698:Analgesia; D002766:Cholecystokinin / Q000502:physiology; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000502:physiology; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology*; D011949:Receptors, Cholecystokinin / Q000502:physiology; D011979:Receptors, Pituitary Hormone / Q000502:physiology
D011949:Receptors, Cholecystokinin; D011979:Receptors, Pituitary Hormone; C029446:MSH receptor; D009074:Melanocyte-Stimulating Hormones; D002766:Cholecystokinin
Sistemi anti-analgesici endogeni.