title: Differences in airway responsiveness between children and adults living in the same environment: an epidemiological study in two regions of New South Wales.
abstract: The aim of the present study was to compare the severity of asthma in children and adults living in the same home environments. In winter 1991 and 1992, we studied two large random samples of children living in two different regions; and, three months later, we conducted a study of adults who lived with enrolled children. A total of 805 children and 814 adults attended in Lismore, and 850 children and 711 adults in Wagga Wagga. Questionnaires were used to measure symptom history, histamine inhalation challenge to measure airway hyperresponsiveness (AHR) and skin-prick tests to measure allergy. There was a higher prevalence of asthma in children than in adults: recent wheeze was 1.5 times higher; asthma medication use was 1.5 times higher; diagnosed asthma was 1.6 times higher; and AHR was two times higher. Current asthma (AHR and recent wheeze) was 9.5-11.3% in children and 5.4-5.6% in adults. These differences were statistically significant. In both regions, airway responsiveness was more severe in children who were sensitized to common allergens than in similarly sensitized adults. These results suggests that airways can develop protective mechanisms with age, or that recent environmental changes in factors such as allergen levels, diet or treatment practices have led to immunological changes and to increased airway responsiveness in this generation of children.
authors: Dept of Medicine, University of Sydney, NSW, Australia.
authors: J K
authors: JK
authors: Peat
authors: E J
authors: EJ
authors: Gray
authors: C M
authors: CM
authors: Mellis
authors: S R
authors: SR
authors: Leeder
authors: A J
authors: AJ
authors: Woolcock
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000453:epidemiology; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012882:Skin Tests
chemical_list: D000485:Allergens