[Features of reoxygenation-induced damage to ischemic kidney during heparin administration].
Albino rat experiments were undertaken to examine the protective action of heparin and the specific features of secondary renal ischemic changes when the agent was administered in different doses during revascularization. Ischemia was induced by 90-min ligation of the renal vessels and the ureter. Heparin was found to have a dose-dependent capacity to prolong rats' survival after ischemia of a single kidney. There were qualitative distinctions of morphological changes in the heparin-treated kidneys as compared with those in the control.
Vorob'eva
N D
ND
Anikin
G D
GD
D000818:Animals; D006493:Heparin / Q000627:therapeutic use*; D007511:Ischemia / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D010100:Oxygen / Q000009:adverse effects*; D051381:Rats; D015427:Reperfusion Injury / Q000517:prevention & control*
D006493:Heparin; D010100:Oxygen
Osobennosti reoksigenatsionnykh povrezhdeniĭ ishemizirovannoĭ pochki na fone vvedeniia geparina.