title: Serum interleukin 1 beta levels as a marker in hairy cell leukemia: correlation with disease status and sIL-2R levels.
abstract: Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder of the B cell lineage. In the search for specific markers with prognostic significance we evaluated the clinical value of IL-1 beta and sIL-2R levels in HCL patients. HCL patients (25) were classified according to their clinical status as "active", "non active" disease or partial or complete remission and response treatment. We found a good correlation between IL-1 beta or IL-2R levels and disease activity: improved clinical status or response to different therapies were associated with decreasing IL-1 beta or sIL-2R levels. In contrast, lack of response to therapy or disease progression was reflected in increases in both IL-1 beta and sIL-2R levels. In some patients increases of both cytokines preceded clinical symptoms. In conclusion our results show that IL-1 beta and s-IL-2R levels may be used as reliable markers for monitoring HCL activity, assessing response to treatment and predicting early progression of disease.
authors: Department of Hematology, Hadassah University Hospital, Hebrew University Medical School, Jerusalem, Israel.
authors: V
authors: V
authors: Barak
authors: B
authors: B
authors: Nisman
authors: E J
authors: EJ
authors: Dann
authors: I
authors: I
authors: Kalickman
authors: R
authors: R
authors: Ruchlemer
authors: M A
authors: MA
authors: Bennett
authors: A
authors: A
authors: Polliack
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007943:Leukemia, Hairy Cell / Q000097:blood* / Q000473:pathology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012995:Solubility
chemical_list: D014408:Biomarkers, Tumor; D007375:Interleukin-1; D015375:Receptors, Interleukin-2