[Insulin resistance and hypertension].
In this study, we have measured plasma glucose and insulin levels at fasting and following an oral glucose load (75g) in 39 non-diabetic subjects (22 untreated hypertensive, 17 normotensive subjects). We also assessed plasma cholesterol (Ch), triglyceride (TG) levels and Na(+)-K(+)-pump activity in the membranes of their erythrocytes. Overall, hypertensive subjects have hypercholesterol, hypertriglyceride, glucose intolerance and hyperinsulinemia. These changes accorded with Syndrome X proposed by Reaven. In multivariant analysis, after correcting for age, BMI, diastolic pressure (DBP) was positively related to fasting, 1/2h insulin and insulin area under cure (AUC) (P < 0.05). Both systolic pressure (SBP) and DBP were negatively correlated to Na(+)-K(+)-pump (P < 0.01, 0.001), while Na(+)-K(+)-pump was negatively fasting, 1/2h, 1h, 2h insulin levels and insulin AUC (P < 0.05, 0.05, 0.01, 0.01, respectively). These results showed that insulin may affect Na(+)-K(+)-pump activity to develop hypertension independent of age and obese. We also postulated that insulin resistance was causal in the syndrome X, also one of factors developing coronary artery disease.
He
R H
RH
Department of Endocrinology, First Affiliated Hospital of Nanjing Medical College.
Ding
G X
GX
Chen
J W
JW
D002784:Cholesterol / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase