Effect of exercise training on the onset of type I diabetes in the BB/Wor rat.
The effects of regular exercise training on the onset and/or severity of hyperglycemia were studied in female diabetes-prone Biobreeding/Worcester (DP BB/Wor) rats. At 38-39 d of age, animals were weight-matched and randomly assigned to exercise-trained (T) and untrained (Unt) groups. The T rats exercised on a rodent treadmill at a moderate workload, 5 successive days with the 6th day being one of rest. Training lasted 5-11 wk until rats became moribund. Red gastrocnemius muscle citrate synthase activity was significantly higher in T (54.2 +/- 4.7 mumol.g-1.min-1) compared with Unt (42.9 +/- 5.1). No significant difference was found between the T and Unt groups in the following: age at onset of hyperglycemia (T = 82.9 +/- 8.7 d; Unt = 82.0 +/- 13.5 d, mean +/- SD), ultimate level of hyperglycemia, age of death (T = 89.9 +/- 9.2 d; Unt = 89.4 +/- 13.9 d), number of days between onset of hyperglycemia and death, or body weights at the onset of hyperglycemia. No significant difference was found between groups in pancreatic insulin concentration (microgram.g-1 of protein), T = 0.22 +/- 0.04; Unt = 0.20 +/- 0.34. These data suggest that a program of regular exercise training may not delay the onset and/or reduce the severity of hyperglycemia in the DP BB/Wor rat. Regular exercise training had no beneficial or detrimental effect on pancreatic beta-cell destruction.
Noble
J D
JD
Noll Physiological Research Center, Pennsylvania State University, University Park 16802.
Farrell
P A
PA
D017668:Age of Onset; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D011913:Rats, Inbred BB
D007328:Insulin