Murine recombinant interleukin-12 increases the acquisition of allergic contact dermatitis in the mouse.
Interleukin-12 (IL-12) is a heterodimeric cytokine that has pleiotropic effects on the immune response. We have studied the effect of recombinant IL-12 on allergic contact dermatitis in the mouse. IL-12 substantially up-regulates the induction of sensitivity to the contact allergens dinitrofluorobenzene and oxazolone.
Maguire
H C
HC
Department of Medicine, Thomas Jefferson University School of Medicine, Philadelphia, Pa.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004139:Dinitrofluorobenzene / Q000276:immunology; D005260:Female; D018664:Interleukin-12 / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D011994:Recombinant Proteins; D018664:Interleukin-12; D004139:Dinitrofluorobenzene