Hodgkin's disease associated with chronic myeloid leukemia. Determination of bcr-abl rearrangement in paraffin-embedded tumors using the polymerase chain reaction.
A patient showing lymph node enlargement and tumors in the neck and axilla in the course of Philadelphia (Ph1) chromosome-positive chronic myeloid leukemia (CML) was seen. There were no hematological findings suggestive of crisis. RNA was isolated from formalin-fixed and paraffin-embedded tissue specimens for the polymerase chain reaction of bcr-abl. CML-type products were detected in the peripheral blood, but no bcr-abl products were found in the lymph nodes. These findings indicate a very rare case in which Hodgkin's disease developed during the course of CML.
Takimoto
Y
Y
Department of Internal Medicine, Hiroshima University, Japan.
Tanabe
O
O
Kuramoto
A
A
Sasaki
N
N
Nanba
K
K
D001483:Base Sequence; D001856:Bone Marrow Examination; D002908:Chronic Disease; D016044:Fusion Proteins, bcr-abl / Q000032:analysis*; D006689:Hodgkin Disease / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D012334:RNA, Neoplasm / Q000032:analysis
D012334:RNA, Neoplasm; D016044:Fusion Proteins, bcr-abl