title: The HLA class I-CML association revisited taking into account the two forms of gene fusion in the Philadelphia chromosome. A multicenter study.
abstract: CML patients possess either a b3-a2 or a b2-a2 fusion between the BCR and ABL genes. Depending on the type of fusion, two different series of non-self potentially immunogenic peptides may be produced. If they are presented by HLA class I molecules and recognized by cytotoxic CD8 lymphocytes, individuals could be more susceptible or resistant to leukemic cells bearing one or the other form of fusion according to their HLA class I phenotype. To test this point, the frequencies of HLA-A and HLA-B alleles were compared between b3-a2 and the b2-a2 CML patients. In essence, no difference was found whose significance could withstand correction for multiple comparisons.
authors: Dipartimento di Scienze Mediche, Università di Torino, Novara, Italy.
authors: P M
authors: PM
authors: Richiardi
authors: R
authors: R
authors: Tosi
authors: G
authors: G
authors: Martinelli
authors: G
authors: G
authors: Saglio
authors: R
authors: R
authors: Conte
authors: M
authors: M
authors: Barbanti
authors: A
authors: A
authors: Dall'Omo
authors: P
authors: P
authors: Farabegoli
authors: B
authors: B
authors: Favoino
authors: C
authors: C
authors: Gambelunghe
mesh_terms: D001483:Base Sequence; D016009:Chi-Square Distribution; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006801:Humans; D007558:Italy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D010677:Philadelphia Chromosome; D016133:Polymerase Chain Reaction
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D016044:Fusion Proteins, bcr-abl