title: [Perfusion of the left ventricular myocardium in patients with aortic valve diseases using single photon emission computerized tomography].
abstract: To determine resting myocardial perfusion in 30 patients with aortic valve disease (AVD) TI-201 emission computer tomography (ECT) studies and heart catheterization were performed. 16 patients had a predominant aortic regurgitation (AR); an aortic stenosis (AS) was found in 14 patients at catheterization. Perfusion defects were documented in 10 of 16 patients with AR, and in 5 of 14 patients with AS. Regional determination demonstrated in 10 of these 15 abnormal cases at least one of the perfusion defects in the postero-basal segment. In patients with aortic valve disease and normal myocardial perfusion scintigraphy, the ejection fraction (EF) was significantly higher (p < 0.05) as compared to the patients with abnormal TI-201 ECT (EF 65.2 +/- 15.0% vs. 58.9 +/- 15.1%). Additionally, in the 15 patients with abnormal TI-201 ECT, the left ventricular end-diastolic volume index (LVEDVI) and the left ventricular end-systolic volume index (LVESVI) were both increased (LVEDVI in AVD: 130.3 +/- 15.3 ml/m2 vs. 107.4 +/- 13.6 ml/m2, LVESVI in AVD: 61.9 +/- 14.6 ml/m2 vs. 48.0 +/- 9.8 ml/m2). In conclusion, left ventricular perfusion defects at rest can be detected by TI-201 ECT in many patients with aortic valve disease. Such myocardial perfusion defects indicate left ventricular enlargement and impaired left ventricular function, especially in patients with aortic regurgitation.
authors: Abt. III, Universität Tübingen.
authors: R
authors: R
authors: Nies
authors: H
authors: H
authors: Hanke
authors: U
authors: U
authors: Helber
authors: W
authors: W
authors: Müller-Schauenburg
authors: H M
authors: HM
authors: Hoffmeister
mesh_terms: D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D013794:Thallium Radioisotopes
vernacular_title: Untersuchungen zur Perfusion des linksventrikulären Myokards bei Patienten mit Aortenklappenvitien mittels Single-Photon-Emissions-Computertomographie.