Urapidil compared with diuretics in the treatment of mild-to-moderate essential hypertensive patients: effects on glucose metabolism, insulin sensitivity, and lipid profile.
In this study, 14 mild-to-moderate essential hypertensive patients of both sexes were studied with regard to the effects of two different treatments, urapidil (60 to 180 mg/day) and diuretics (chlorthalidone and hydrochlorothiazide-25 to 50 mg/day) on glucose metabolism, insulin sensitivity and plasma lipid profile. Blood pressure was equally reduced by both treatments. However, urapidil treatment was accompanied by significant lower plasma levels of cholesterol, HDL-cholesterol and triglycerides as compared with diuretic treatment. Also, a significantly higher insulin sensitivity index, determined by the euglycemic insulin clamp technique, was observed during urapidil therapy. Our results demonstrated that urapidil is as effective as diuretics in reducing blood pressure of essential hypertensive patients, with the potential advantage of a favorable profile in regard to the glucose and lipid metabolisms.
De Lima
M D
MD
Nephrology Division, Escola Paulista de Medicina, São Paulo, Brazil.
Kohlmann
N E
NE
Neves
F A
FA
Zanella
M T
MT
Ribeiro
A B
AB
Kohlmann
O
O
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002752:Chlorthalidone / Q000627:therapeutic use*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D007328:Insulin / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D007328:Insulin; D008055:Lipids; D010879:Piperazines; D006852:Hydrochlorothiazide; C015568:urapidil; D005947:Glucose; D002752:Chlorthalidone