Adaptive response to ionizing radiation in normal and aneuploid human lymphocytes.
The ability to induce an adaptive response by low doses of gamma rays was studied in normal and trisomic lymphocytes (47, XX or XY, +21). The results indicate the presence of an adaptive response in lymphocytes of 3 normal donors, but in lymphocytes of 5 donors with trisomy 21 no significant adaptive response after irradiation with a low dose of gamma rays was found. There was similar chromosomal radiosensitivity in normal and trisomic lymphocytes (47, XX or XY, +21) irradiated with 1.50 Gy at the 48th hour after stimulation.
Kalina
I
I
Department of Medical Biology, Medical Faculty, Safarik University, Kosice.
Konecná
H
H
Némethová
G
G
Raceková
N
N
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004314:Down Syndrome / Q000473:pathology; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D011836:Radiation Tolerance / Q000502:physiology*; D014314:Trisomy