Disturbances of morphological parameters in blood of rats orally exposed to aluminum chloride.
The aim of this work was to assess changes of morphological parameters in the blood of rats after oral (po) administration of aluminum (Al), in relation to the time and the administered dose. The experiment was performed on female Wistar rats. The animals were administered aluminum chloride (100 mg Al/kg) daily for 21 d. Morphological assays: red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), iron serum concentration (Fe), MCH, MCHC, absolute corrected reticulocyte count (ACRC), white blood cells (WBC), and platelet count (PLT) were estimated on d 3, 7, 14, and 21, both in the control group and in intoxicated rats. After wk 1 of aluminum administration we observed a decrease of RBC, HCT, HGB and serum iron concentration in the blood of rats. The increase of the platelet count was observed earlier than changes in other parameters. Investigation has proved that the exposure of rats to aluminum administered orally results in normocytic anemia.
Chmielnicka
J
J
Department of Toxicological Chemistry, Medical University, Lódź, Poland.
Nasiadek
M
M
Pínkowski
R
R
Paradowski
M
M
D000284:Administration, Oral; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D000740:Anemia / Q000139:chemically induced*; D000818:Animals; D001773:Blood Cells / Q000187:drug effects*; D002712:Chlorides / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004906:Erythrocyte Count / Q000187:drug effects; D004909:Erythrocyte Indices / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron / Q000097:blood*; D007958:Leukocyte Count / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017701:Reticulocyte Count / Q000187:drug effects
D017607:Aluminum Compounds; D002712:Chlorides; D006454:Hemoglobins; D000077410:Aluminum Chloride; D007501:Iron