5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment.
The synthesis of some arylpiperazines with a benzamide moiety on N-4 alkyl chain was accomplished and their dopaminergic and serotonergic affinity was assayed by in vitro receptor binding. The results of such investigation showed a moderate affinity on D-2 receptors and a lack of 5-HT receptor affinity.
Perrone
R
R
Dipartimento Farmaco-Chimico, Bari, Italy.
Berardi
F
F
Leopoldo
M
M
Tortorella
V
V
Lograno
M D
MD
Daniele
E
E
Govoni
S
S
D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism
D001549:Benzamides; D010879:Piperazines; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin