Acute generalized exanthemic pustulosis.
Acute generalized exanthemic pustulosis often presents dramatically with the abrupt onset of a widespread pustular eruption on an erythematous base, with a frequently positive Nikolsky sign. In most cases, penicillins or macrolides are causally related. The main differential diagnosis of a generalized pustular eruption in a febrile patient is pustular psoriasis, which can be differentiated on both a clinical and histologic basis.
Manders
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SM
Division of Dermatology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Marlton.
Heymann
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D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000667:Ampicillin / Q000009:adverse effects; D002437:Cefazolin / Q000009:adverse effects; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000209:etiology*; D005076:Exanthema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects; D010406:Penicillins / Q000009:adverse effects*; D011565:Psoriasis / Q000139:chemically induced*
D010406:Penicillins; D008795:Metronidazole; D000667:Ampicillin; D002437:Cefazolin