title: Ischemic tolerance can be induced repeatedly in the gerbil hippocampal neurons.
abstract: We investigated whether ischemic tolerance can be induced repeatedly in the gerbil hippocampal neurons. The gerbils were firstly treated with two episodes of 2-min forebrain ischemia 1 day apart, which procedure is known to induce ischemic tolerance. After 4 weeks of recirculation, the animals were subjected to a 2-min period of preconditioning ischemia again and then to a 3-min period of ischemia after 3 days. The hippocampal CA1 neurons were destroyed 7 days after 3-min ischemia without the second preconditioning but not in animals with the second preconditioning. Thus, ischemic tolerance can be induced repeatedly when the first ischemic tolerance has disappeared.
authors: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
authors: T
authors: T
authors: Chen
authors: H
authors: H
authors: Kato
authors: X H
authors: XH
authors: Liu
authors: T
authors: T
authors: Araki
authors: Y
authors: Y
authors: Itoyama
authors: K
authors: K
authors: Kogure
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D002452:Cell Count; D016923:Cell Death; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000473:pathology; D012008:Recurrence