Optimum rate of administration of propofol for induction of anaesthesia in rats.
Twenty rats received propofol 2.5, 5, 10 or 20 mg kg-1 min-1 i.v. Brain activity was monitored using the electroencephalogram (EEG). As the endpoint for induction of anaesthesia we used a burst suppression period of 1 s or longer. At a fast (20 mg kg-1 min-1) rate of administration, the induction dose was significantly larger compared with a slower rate (10 mg kg-1 min-1). At a slow rate of administration (2.5 mg kg-1 min-1), the induction dose was also significantly larger compared with a rate of 10 mg kg-1 min-1. In spite of different dose requirements at different rates of administration, duration of anaesthesia was not significantly different.
Larsson
J E
JE
Department of Pharmacology, University of Umeå, Sweden.
Wahlström
G
G
D000771:Anesthesia, Intravenous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D008297:Male; D015742:Propofol / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D015742:Propofol