Chromatin self-organization by mutation bias.
Proteins, on binding to a DNA sequence, alter the frequency and quality of mutations that occur in the sequence. This represents a reverse flow of information from proteins to DNA. Nucleosome binding causes patterns of UV-induced damage which, when converted to mutations by replication, will phase nucleosomes. We propose that DNA binding proteins create their own high- or low-affinity binding sites along DNA sequences by biased mutational pressure.
Holmquist
G P
GP
Department of Biology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010.
D005075:Biological Evolution; D002843:Chromatin / Q000235:genetics* / Q000648:ultrastructure; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D008957:Models, Genetic; D016296:Mutagenesis / Q000235:genetics*; D009707:Nucleosomes / Q000378:metabolism; D014466:Ultraviolet Rays
D002843:Chromatin; D004268:DNA-Binding Proteins; D009707:Nucleosomes; D004247:DNA