title: [Study of the spatial organization of the globular fragment of calmodulin. I. Conformational analysis of the domain structure].
abstract: Theoretical conformational analysis of dodecapeptide "loop" of one of four domains of CaM is carried out. It's shown that one of the lowest energy conformations of the "loop" can bring about together E(i)- and F(i)-hands till van-der-waals contacts. Predominance and advantages of the calculated conformations are discussed in connection with structural organization of the domains and their capability to bind Ca(2+)-ions. The proposed "alpha-hairpin" structure of the domains is a part of a supersecondary structure of globular lobe of CaM.
authors: A Ia
authors: AIa
authors: Avanov
mesh_terms: D000595:Amino Acid Sequence; D002147:Calmodulin / Q000378:metabolism*; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary
chemical_list: D002147:Calmodulin
vernacular_title: Issledovanie prostranstvennoĭ organizatsii globuliarnogo fragmenta kalmodulina. I. Konfomatsionnyĭ analiz struktury domena.