Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor.
We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (> 40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.
Mishina
Y
Y
Department of Molecular Genetics, University of Texas, M. D. Anderson Cancer Center, Houston 77030.
Suzuki
A
A
Gilbert
D J
DJ
Copeland
N G
NG
Jenkins
N A
NA
Ueno
N
N
Behringer
R R
RR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D052004:Bone Morphogenetic Protein Receptors; D019485:Bone Morphogenetic Proteins; D002874:Chromosome Mapping; D016384:Consensus Sequence; D003433:Crosses, Genetic; D005091:Exons; D005260:Female; D007438:Introns; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008969:Molecular Sequence Data; D009115:Muridae / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D017978:Receptors, Growth Factor
D019485:Bone Morphogenetic Proteins; D011506:Proteins; D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor; D052004:Bone Morphogenetic Protein Receptors