Use of in vitro human metabolism studies in drug development. An industrial perspective.
Rodrigues
A D
AD
Drug Metabolism Department, Abbott Laboratories, Abbott Park, IL 60064.
D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004345:Drug Industry / Q000379:methods*; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013347:Subcellular Fractions / Q000201:enzymology; D014019:Tissue Donors
D065607:Cytochrome P-450 Enzyme Inhibitors; D007527:Isoenzymes; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System