title: A new human gene (DXS1357E) with ubiquitous expression, located in Xq28 adjacent to the adrenoleukodystrophy gene.
abstract: We have isolated a new human gene (DXS1357E; laboratory name: CDM) localized in Xq28. This gene is transcribed from the same CpG island as the adrenoleukodystrophy gene (ALD) and oriented in the opposite direction. It encodes a 1.5-kb transcript that exhibits ubiquitous expression and contains a single open reading frame. The 246 deduced amino acid sequence suggests the presence of membrane-associated segments and a weak similarity with the rod-like tail portion of heavy chain myosins from different species. The DXS1357E gene may be a candidate for one of the many diseases mapping to this region. A preliminary analysis did not show rearrangements of the gene in 19 independent patients with Emery-Dreifuss muscular dystrophy.
authors: Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Génétique Moléculaire de l'INSERM, Strasbourg, France.
authors: J
authors: J
authors: Mosser
authors: C O
authors: CO
authors: Sarde
authors: S
authors: S
authors: Vicaire
authors: J R
authors: JR
authors: Yates
authors: J L
authors: JL
authors: Mandel
mesh_terms: D000326:Adrenoleukodystrophy / Q000235:genetics; D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000235:genetics; D015870:Gene Expression; D005796:Genes; D006801:Humans; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014960:X Chromosome
chemical_list: C091247:BCAP31 protein, human; D018076:DNA, Complementary; D008565:Membrane Proteins; D011506:Proteins