Retroperitoneal fibrosis treated with methylprednisolon pulse and disease-modifying antirheumatic drugs.
The conventional treatment of patients with ureteric obstruction due to retroperitoneal fibrosis (RF) is surgery in combination with long-term corticosteroids. This report describes 11 cases of RF with ureteric obstruction treated with methyl-prednisolon pulse therapy (MPPT) in combination with azathioprine or penicillamine following initial insertion of ureteral stents. The medial treatment suggested was successful in 7 patients, but only moderately effective in the last 4 patients. This principle of non-operative management of RF has not been previously reported.
Harreby
M
M
Department of Rheumatology, Copenhagen County Hospital, Denmark.
Bilde
T
T
Helin
P
P
Meyhoff
H H
HH
Vinterberg
H
H
Nielsen
V A
VA
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D009403:Nephrostomy, Percutaneous; D010396:Penicillamine / Q000008:administration & dosage / Q000627:therapeutic use*; D011859:Radiography; D012185:Retroperitoneal Fibrosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome; D014517:Ureteral Obstruction / Q000209:etiology / Q000628:therapy
D010396:Penicillamine; D001379:Azathioprine; D008775:Methylprednisolone