[Use of liquid sorbents based on chitosan for treatment of diffuse forms of peritonitis].
Chitosan-based gelatinous affinity sorbent containing 9 mg/ml of polymyxin B was injected into the infected peritoneal cavity for twenty-four hours for detoxification in diffuse peritonitis. The clinical assay of blood plasma (Spectrum Abbot, USA) revealed that the lavage of the infected abdomen by polymyxin B-containing adsorbent resulted in systemic detoxification. The effect was associated with normalization of direct bilirubin, cholesterol, and triglyceride levels, a 4-fold decrease in uric acid levels, and a 34-fold increase in alkaline phosphatase activity, and a greater than 70-fold enhancement of hepatic aspartate aminotransferase activity.
Bol'shakov
I N
IN
Nasibov
S M
SM
Kulaev
D V
DV
Lopukhin
Iu M
IuM
D000818:Animals; D002686:Chitin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D048271:Chitosan; D010538:Peritonitis / Q000188:drug therapy*; D011112:Polymyxin B / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D016060:Sorption Detoxification / Q000379:methods*
D002686:Chitin; D048271:Chitosan; D011112:Polymyxin B
Ispol'zovanie zhidkikh sorbentov na osnove khitozana dlia lecheniia razlitoĭ formy peritonita.