Cyclic amidine analogues of taurine and homotaurine: synthesis and effects on rat skeletal muscle.
A series of amidinosulfonic acids IIIa-f, analogs of taurine and homotaurine, was synthesized by reacting 2-aminoethane or 3-aminopropane sulfonic acid with lactim ethers Ia-c and then cyclized to sultams IVa-c and Vd-f. The effects of some selected amidinosulfonic acids III on membrane ionic conductances of rat skeletal muscle are described.
Campagna
F
F
Dipartimento Farmaco-Chimico, Università degli Studi, Bari, Italy.
Carotti
A
A
Casini
G
G
Palluotto
F
F
Pierno
S
S
Tricarico
D
D
De Luca
A
A
Conte-Camerino
D
D
D000578:Amidines / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D013654:Taurine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D000578:Amidines; D013451:Sulfonic Acids; D013654:Taurine; C001355:tramiprosate