Study on the carcinogenicity of tannic acid in F344 rats.
The carcinogenicity of tannic acid, a compound that is used as a food additive, a clarifying agent and a refining agent, was examined in F344 rats of both sexes. Tannic acid was dissolved in distilled water at concentrations of 0.25 and 0.5%. The doses were selected on the basis of results from a 13-wk subchronic study. Groups of 50 male and 50 female rats were given one of these solutions ad lib. as their drinking water for up to 2 yr. The mean body weights of the treated males were essentially comparable with those of the controls, whereas treated females had lower mean body weights than the control group. A variety of tumours developed in all groups, including the control group, but all the neoplasms were histologically similar to those known to occur spontaneously in this strain of rats, and no statistically significant increase in the incidence of any tumour was found in the treated groups of either sex. Thus, it is concluded that, under the conditions of the experiment, tannic acid has neither carcinogenic potential in F344 rats nor modifying effects on spontaneous tumour development.
Onodera
H
H
Division of Pathology, National Institute of Health Sciences, Tokyo, Japan.
Kitaura
K
K
Mitsumori
K
K
Yoshida
J
J
Yasuhara
K
K
Shimo
T
T
Takahashi
M
M
Hayashi
Y
Y
D000284:Administration, Oral; D000818:Animals; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000633:toxicity*; D047348:Hydrolyzable Tannins / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009369:Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344; D015430:Weight Gain / Q000187:drug effects
D016587:Antimutagenic Agents; D005503:Food Additives; D047348:Hydrolyzable Tannins