Analgesic and antiinflammatory activity screening of 6-acyl-3-piperidinomethyl-2(3H)-benzoxazolone derivatives.
6-Acetyl-2(3H)-benzoxazolone derivatives were reacted with appropriate piperidine derivatives and formaldehyde in methanol to give the corresponding 6-acyl-3-piperidinomethyl-2(3H)-benzoxazolones. The obtained compounds were screened for their analgesic and antiinflammatory activities. Analgesic activity of these compounds was investigated by modified Koster test. Antiinflammatory activity was assayed by using carrageenan induced mouse paw edema test and arachidonic acid edema. The 15 compounds synthesized showed good analgesic activities; compounds 1,3 and 6 moved to be active inhibitors of edema.
Erol
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Hacettepe University, Faculty of Pharmacy Pharmaceutical Chemistry Department, Sihhiye-Ankara/Turkey.
Demirdamar
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D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D051379:Mice
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001583:Benzoxazoles; C017057:benzoxazolone