Pdha-2: a model for studying transcriptional regulation in early spermatocytes.
Precise temporal and tissue-specific expression of genes during spermatocyte differentiation is crucial for the formation of functional spermatozoa. However, the mechanisms that regulate gene expression during spermatogenesis are poorly understood. One testis-specific gene, Pdha-2, is beginning to emerge as a potentially important model for the study of these events. This review focuses on our current understanding of the expression and regulation of Pdha-2 during spermatogenesis.
Iannello
R C
RC
Molecular Embryology and Birth Defects Laboratory, Monash Medical Centre, Clayton, Victoria, Australia.
Young
J C
JC
Kola
I
I
D000818:Animals; D001483:Base Sequence; D016384:Consensus Sequence; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D030481:Pyruvate Dehydrogenase (Lipoamide); D011768:Pyruvate Dehydrogenase Complex / Q000096:biosynthesis* / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid; D013090:Spermatocytes / Q000378:metabolism*; D013091:Spermatogenesis; D014158:Transcription, Genetic; D014960:X Chromosome
D011768:Pyruvate Dehydrogenase Complex; D030481:Pyruvate Dehydrogenase (Lipoamide); C065640:pyruvate dehydrogenase E1alpha subunit