title: Reverse redistribution of thallium-201 represents a low-risk finding in thrombolysed patients following myocardial infarction.
abstract: The aim of the study was to evaluate the prevalence and clinical significance of reverse redistribution on thallium-201 imaging in post-myocardial infarction patients who have undergone thrombolytic therapy. Sixty-two patients aged 35-79 (mean 60) years with proven myocardial infarction who had undergone thrombolysis were studied 6 weeks post infarction. Standard stress and 4-h redistribution imaging was performed with 201Tl following treadmill exercise. Separate day rest injection of 201Tl was given after sublingual nitroglycerine; imaging was performed at 1 h. Planar images were acquired in three standard views and semiquantitative segmental analysis of the images was performed from the unprocessed images. All patients had radionuclide ventriculography for the assessment of left ventricular ejection fraction and wall motion abnormality. Thirty-three patients also had coronary angiography. 201Tl scintigraphy revealed fixed defects in 19 patients, reversible defects in 22, and reverse redistribution in 21. Those with reverse redistribution had a significantly higher exercise capacity (P < 0.01). Mean (SD) left ventricular ejection fraction was 46 (12)% for those with fixed defects, 47 (9)% for those with reversible defects and 45 (15)% for patients with reverse redistribution (P = NS). The regional wall motion abnormality score was 8 (5), 11.8 (2.2) and 14.2 (6) respectively in patients with reverse redistribution, redistribution alone and fixed defects. Regions with reverse redistribution revealed less regional wall motion abnormality compared to the other two groups (P < 0.01). Fifteen patients demonstrated significant 201Tl uptake in the region showing reverse redistribution, with rest injection of 201Tl following sublingual nitroglycerine, suggesting viable myocardium in that region.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, Harrow, Middlesex, UK.
authors: B S
authors: BS
authors: Sridhara
authors: E
authors: E
authors: Dudzic
authors: S
authors: S
authors: Basu
authors: R
authors: R
authors: Senior
authors: A
authors: A
authors: Lahiri
mesh_terms: D006328:Cardiac Catheterization; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005996:Nitroglycerin / Q000627:therapeutic use; D015635:Radionuclide Ventriculography; D013794:Thallium Radioisotopes; D015912:Thrombolytic Therapy; D013997:Time Factors
chemical_list: D013794:Thallium Radioisotopes; D005996:Nitroglycerin