title: [The effect of the activation of lipid peroxidation on the structure of extraembryonic organs and the liver in rats at different periods of ontogeny].
abstract: The influence of activation of lipid peroxidation (LP) on morphofunctional organization of extraembryonic compounds and liver on different stages of rat's ontogenesis was studied. It is found that LP-activation (paraquat injection) in late pregnancy leads to extensive vacuolization of trophoblastic and yolk sac cells. In the embryonic liver, the number of hemopoietic cells decreases. During the first days after LP activation in the liver of adult animals, enlargement of granular endoplasmic reticulum elements and their degranulation were revealed. In the liver cells of the offsprings, administered paraquat prenatally, signs of bile formation activation were detected.
authors: Iu V
authors: IuV
authors: Gladyshev
authors: S I
authors: SI
authors: Kolesnikov
authors: A V
authors: AV
authors: Semeniuk
authors: V V
authors: VV
authors: Ivanov
mesh_terms: D000818:Animals; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000196:embryology* / Q000254:growth & development* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010269:Paraquat / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D014327:Trophoblasts / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D015017:Yolk Sac / Q000187:drug effects / Q000196:embryology* / Q000254:growth & development* / Q000648:ultrastructure
chemical_list: D010269:Paraquat
vernacular_title: Vliianie aktivatsii perekisnogo okisleniia lipidov na strukturu vnezarodyshevykh organov i pecheni krys v razlichnye periody ontogeneza.