[The role of thyroid hormones in regulating the activity of phospholipases A1 and A2 in liver cells and nuclei from rats of varying ages].
The activity of phospholipases A1 and A2 in liver cells and liver cell nuclei of rats of various age and the thyroid status of experimental animals have been studied. It was found that phospholipid deacylation and acylation in liver cells is under control of thyroid hormones. Age-specific fluctuations in the activity of the thyroid gland may be one of possible reasons for phospholipase A1 activity and phospholipid level changes in liver nuclei during ontogenesis. Thyroid hormones play an important role in regulation of polyunsaturated fatty acid metabolism and prostaglandin E2 production in the liver.
Babenko
N A
NA
Kavok
N S
NS
D000375:Aging / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology*; D015232:Dinoprostone / Q000096:biosynthesis; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D008297:Male; D010741:Phospholipases A / Q000378:metabolism*; D054466:Phospholipases A1; D051381:Rats; D017208:Rats, Wistar; D013963:Thyroid Hormones / Q000502:physiology*
D005231:Fatty Acids, Unsaturated; D013963:Thyroid Hormones; D010741:Phospholipases A; D054466:Phospholipases A1; D015232:Dinoprostone
Rol' tireoidnykh gormonov v reguliatsii aktivnosti fosfolipaz A1 i A2 v kletkakh i iadrakh kletok pecheni krys raznogo vozrasta.