Correlation between disease activity and T-cell CD3 zeta chain expression in a B-cell lymphoma.
The T-cell receptor (TCR)/CD3 complex is the surface molecule responsible for the highly specific response to foreign antigens, including tumour-associated antigens. and correlations have been observed with disease status. Recently, low amounts of CD3 gamma and CD3 zeta chains in the CD3/TCR complex have been reported in long-term tumour-bearing mice as a possible mechanism for the impaired T-cell responses. In this study we report a B-cell lymphoma in which T-cell CD3 zeta expression correlated with disease activity.
Massaia
M
M
Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Italy.
Attisano
C
C
Beggiato
E
E
Bianchi
A
A
Pileri
A
A
D017252:CD3 Complex / Q000097:blood*; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology*; D008213:Lymphocyte Activation; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000276:immunology*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014057:Tomography, X-Ray Computed
D017252:CD3 Complex; D006684:HLA-DR Antigens