Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient.
A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.
Jonveaux
P
P
Unité INSERM U301, Institut de Génétique Moléculaire, Paris, France.
Hillion
J
J
Bernard
O
O
Le Coniat
M
M
Derré
J
J
Flexor
M
M
Larsen
C J
CJ
Berger
R
R
D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D002896:Chromosomes, Human, Pair 6; D005047:Etoposide / Q000009:adverse effects; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000139:chemically induced / Q000235:genetics*; D014178:Translocation, Genetic
D005047:Etoposide