title: [ANSA analysis. II. Aminonaphthalenesulfonamides--detecting groups for polysubstrate analysis of proteases].
abstract: The properties and synthetic methods of aminonaphthalenesulfonamides (ANSA) used as detectable groups of protease substrates are described. A list of chemical and physical properties of seventeen 5.1-ANSA with simple substituents is presented. A comparison of condition for the introduction and removal of acyl protecting groups (acetyl, trifluoroacetyl, phthaloyl, carbobenzoxy) used in ANSA synthesis is given. Examples of applicability of nitronaphthalenesulfonamides as intermediate compounds are given. The possibility of ANSA alkylation at both N(C) and N(S) is demonstrated. Substituted ANSA--sulfonylaziridenes--are used for the production of water-soluble derivatives containing the alcoxy group in the sulfonamide fragment. Criteria for the selection of detectable groups for polysubstrate analysis are discussed. Eighteen typical procedures for ANSA synthesis according to the schemes discussed are presented.
authors: A M
authors: AM
authors: Trushkin
authors: A G
authors: AG
authors: Kazantsev
authors: N V
authors: NV
authors: Kuznetsov
authors: A D
authors: AD
authors: Iakhimovich
authors: G Iu
authors: GIu
authors: Moguchaia
authors: E V
authors: EV
authors: Rodina
authors: N A
authors: NA
authors: Gridneva
authors: I G
authors: IG
authors: Sharina
authors: A A
authors: AA
authors: Nedospasov
mesh_terms: D000478:Alkylation; D000817:Anilino Naphthalenesulfonates; D002863:Chromogenic Compounds; D010450:Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D000817:Anilino Naphthalenesulfonates; D002863:Chromogenic Compounds; C039256:6-anilino-1-naphthalenesulfonic acid; D010450:Endopeptidases
vernacular_title: ANSA-analiz. II. Aminonaftalinsul'fonamidy--detektiruemye gruppy dlia polisubstratnogo analiza proteaz.