title: Long-term effects of postoperative total parenteral nutrition supplemented with glycylglutamine on subjective fatigue and muscle protein synthesis.
abstract: Seventeen patients undergoing elective open cholecystectomy were given conventional total parenteral nutrition either with (nine patients) or without (eight) glutamine supplementation of 20 g/day for 3 days after surgery and thereafter ordinary food for the following 27 days. Muscle protein synthesis, as assessed by the total concentration of ribosomes, decreased in control patients on day 3 following surgery and remained low on days 10, 20 and 30 (P < 0.05). In patients who received glutamine the total ribosome concentration was maintained on the third day after operation. Concurrently, the subjective feeling of fatigue increased on days 3 and 10 after surgery and the nitrogen balance was negative after operation in both groups, without any difference related to glutamine supplementation. Intravenous glutamine after surgery counteracts a decline in muscle protein synthesis only for as long as it is provided.
authors: Department of Anaesthesiology and Intensive Care, Karolinska Institute, St Göran's Hospital, Stockholm, Sweden.
authors: B
authors: B
authors: Petersson
authors: A
authors: A
authors: von der Decken
authors: E
authors: E
authors: Vinnars
authors: J
authors: J
authors: Wernerman
mesh_terms: D002763:Cholecystectomy; D004151:Dipeptides / Q000008:administration & dosage* / Q000378:metabolism; D005221:Fatigue / Q000178:diet therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000096:biosynthesis*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D011132:Polyribosomes / Q000378:metabolism; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D004151:Dipeptides; D009124:Muscle Proteins; C039788:glycylglutamine; D009584:Nitrogen