[The sensitivity of tumor cells to low doses of antitumor preparations].
The anticancer activity of water solutions of nitrosomethylurea, adriblastin and cisplatin at low and extra low concentrations (to 10(-15) M) was studied in the mice with experimentally induced tumor. Single and multiple administration of these drugs at extra low doses changed the life duration. Nitrosomethylurea (10(-15) M) increased the life duration by 20-86%. Nitrosomethylurea at extra low concentrations modifies the organism and tumor sensitivity to subsequent action of a high dose of this drug.
Krutova
T V
TV
Ostrovskaia
L A
LA
Rykova
V A
VA
Korman
D B
DB
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000401:mortality; D002945:Cisplatin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage; D004354:Drug Screening Assays, Antitumor; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000401:mortality; D008770:Methylnitrosourea / Q000008:administration & dosage; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy*
D000970:Antineoplastic Agents; D008770:Methylnitrosourea; D004317:Doxorubicin; D002945:Cisplatin
Chuvstvitel'nost' opukholevykh kletok k nizkim dozam protivoopukholevykh preparatov.