title: A simple modification in operative technique can reduce the incidence of nonanastomotic biliary strictures after orthotopic liver transplantation.
abstract: Nonanastomotic strictures after liver transplantations are a source of significant morbidity, often necessitating retransplantation. The purpose of this study was twofold: first to identify features associated with the development of this lesion; second, to make technical modifications that will decrease the incidence of this problem. In the first part of this study, 15 of 131 patients were diagnosed with nonanastomotic biliary stricture. A stepwise logistic-regression analysis associated donor cold ischemic time and dopamine dose with the development of nonanastomotic biliary strictures. All these patients had arterial reconstruction after partial revascularization of the liver with portal venous blood. Because the bile duct receives its blood supply from only the hepatic artery, we hypothesized that the prolonged period of warm ischemia from staged reconstruction of the vascular supply would promote the development of this lesion. In a second part of this study, the stricture rate in 45 patients with simultaneous revascularization using both the hepatic artery and portal vein was compared with that in 83 patients from the first part of this study initially revascularized with portal venous blood. All patients in the second study had grafts preserved using UW solution. Only 1 patient with simultaneous revascularization developed a nonanastomotic biliary stricture. Because we were unable to identify any significant complications related to this method of revascularization, we propose that the hepatic artery and portal vein should be released simultaneously, especially in patients receiving a graft with prolonged storage time.
authors: Department of Surgery, Rush Presbyterian St. Lukes Medical Center, Chicago, IL 60612.
authors: H N
authors: HN
authors: Sankary
authors: L
authors: L
authors: McChesney
authors: E
authors: E
authors: Frye
authors: S
authors: S
authors: Cohn
authors: P
authors: P
authors: Foster
authors: J
authors: J
authors: Williams
mesh_terms: D000241:Adenosine; D000493:Allopurinol; D000714:Anastomosis, Surgical; D001158:Arteries / Q000473:pathology; D001649:Bile Duct Diseases / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D002758:Cholangiography; D005978:Glutathione; D006801:Humans; D007328:Insulin; D008099:Liver / Q000473:pathology; D008102:Liver Circulation; D016031:Liver Transplantation / Q000379:methods*; D019188:Organ Preservation Solutions; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011309:Preservation, Biological; D011887:Raffinose; D012086:Reoperation; D012307:Risk Factors
chemical_list: D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose