title: [Circulation time determined by carotid angiography in patients with chronic internal carotid artery occlusion: comparison with cerebral blood flow and oxygen metabolism measured by PET].
abstract: The degree of collateral circulation in patients with unilaterally chronic internal carotid artery occlusion was estimated by mean transit time of contrast material in rapid sequence carotid angiography (Angiographic MTT), and compared with cerebral blood flow and oxygen metabolism measured by PET. In normal density region on X-ray CT, a significant negative correlation was observed between Angiographic MTT and cerebral blood flow (CBF). This indicates that cerebral blood flow can be estimated by Angiographic MTT. It has been reported that the ratio of cerebral blood volume (CBV) to CBF (CBV/CBF), i.e., mean transit time determined by PET well agreed with OEF, and is good indicator for brain circulation reserve. In this study, no significant correlation was observed between Angiographic MTT and CBV/CBF. However, a significant positive correlation was observed between Angiographic MTT and oxygen extraction fraction (OEF), and no significant correlation was observed between Angiographic MTT and oxygen consumption rate (CMRO2). These indicates that Angiographic MTT may be indicator for brain circulation reserve.
authors: Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita.
authors: H
authors: H
authors: Ito
authors: A
authors: A
authors: Inugami
authors: F
authors: F
authors: Shishido
authors: T
authors: T
authors: Okudera
authors: T
authors: T
authors: Ogawa
authors: J
authors: J
authors: Hatazawa
authors: H
authors: H
authors: Fujita
authors: E
authors: E
authors: Shimosegawa
authors: I
authors: I
authors: Kanno
authors: H
authors: H
authors: Fukuda
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002341:Carotid Artery Thrombosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002343:Carotid Artery, Internal; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D013997:Time Factors; D014055:Tomography, Emission-Computed
chemical_list: D010100:Oxygen