[Changes in immune status due to anesthesia and surgical intervention. The role of thymopentin and interleukins].
OBJECTIVE
Purpose of the study was clinical evaluation of thymopentin and interleukins in the changes of immunity due to anesthesia and surgical operation.


METHODS
After randomization the patients were divided into four groups according to starter type (thiopental or propofol) and immunological pre-treatment (tymopentin or saline of control group) administered for three days before and two days after operation.


METHODS
The study was effected on 40 patients undergoing venous vascular surgery in operating rooms of Medical School of University of Genoa.


METHODS
At pre-established times (basal, before and after induction, recovery and 72 postoperative hours) were measured some immunological data (plasmatic concentrations of red blood cells, white blood cells, lymphocyte cells, antibodies, complement analysis, interleukins 1 and 2).


RESULTS
The results show a depression of immunity with hypoleucocistosis and hyperlymphocytosis due to surgical trauma or to anesthesia drugs.


CONCLUSIONS
Pre-treatment with thymopentin no change perioperative immunity and the role of interleukins isn't clear; the immunological depression is the same in thiopental of propofol groups.
Launo
C
C
Istituto di Anestesia e Rianimazione, Università degli Studi di Genova.
De Grandi
R
R
Augeri
C
C
Palermo
S
S
Cammardella
M P
MP
Mauro
E
E
Doveri
A
A
Maio
M
M
Mantelli
C
C
D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D007970:Leukopenia / Q000209:etiology* / Q000517:prevention & control; D008218:Lymphocytosis / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology*; D011292:Premedication; D015742:Propofol / Q000009:adverse effects*; D013874:Thiopental / Q000009:adverse effects*; D016305:Thymopentin / Q000008:administration & dosage / Q000627:therapeutic use*; D014648:Varicose Veins / Q000601:surgery
D007375:Interleukin-1; D007376:Interleukin-2; D013874:Thiopental; D016305:Thymopentin; D015742:Propofol
Modificazioni dello stato immunitario indotte dall'anestesia e dall'intervento chirurgico. Il ruolo della timopentina e delle interleuchine.