3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities.
The synthesis of 4-amino-3,5-diphenyl-1H-pyrazole-1-ethanol, as well as of their N-methyl, N-ethyl and N,N-dimethyl derivatives is described. A series of 1-(2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazole-4-amines and of N-substituted 4-dimethylamino-3,5-diphenyl-1H-pyrazole-1-ethanamines were also prepared. Some of the above compounds showed remarkable local anesthetic, analgesic and in vitro platelet antiaggregating activities, as well as moderate antiinflammatory and antipyretic activities in rats and mice.
Bruno
O
O
Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
Ranise
A
A
Bondavalli
F
F
Schenone
S
S
D'Amico
M
M
Falciani
M
M
Vacca
C
C
Filippelli
A
A
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D051379:Mice; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D000779:Anesthetics, Local; D010975:Platelet Aggregation Inhibitors; D011720:Pyrazoles