Coadministration of fluvoxamine increases serum concentrations of haloperidol.
Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly elevated by fluvoxamine.
Daniel
D G
DG
Clinical Brain Disorders Branch, NIMH Neuroscience Center at Saint Elizabeths, Washington, D.C.
Randolph
C
C
Jaskiw
G
G
Handel
S
S
Williams
T
T
Abi-Dargham
A
A
Shoaf
S
S
Egan
M
M
Elkashef
A
A
Liboff
S
S
D000328:Adult; D001590:Benztropine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D002908:Chronic Disease; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D016666:Fluvoxamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D001590:Benztropine; D006220:Haloperidol; D016666:Fluvoxamine