title: The role of T cell receptor beta chain genes in susceptibility to rheumatoid arthritis.
abstract: OBJECTIVE
  To evaluate the role of the T cell receptor beta chain locus (TCRB) in genetic susceptibility to rheumatoid arthritis (RA).
  
  
  METHODS
  Twenty-eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V beta 6.7), a V beta 12.2 SSCP marker, and a biallelic C beta restriction fragment length polymorphism. Data were analyzed by the SIBPAL program to assess identity-by-descent in affected sib-pairs.
  
  
  RESULTS
  Using the V beta 12.2 marker, there was suggestive evidence of increased sib-pair sharing (P = 0.005) in affected offspring (a P value of 0.001 is generally taken to establish linkage). Data for V beta 6.7 and C beta yielded significance levels of 0.06 and 0.19, respectively.
  
  
  CONCLUSIONS
  These data suggest that a gene in or linked to the TCRB complex may confer genetic susceptibility to RA in these families. Confirmation in a larger panel of families is required.
authors: Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland.
authors: M
authors: M
authors: McDermott
authors: D L
authors: DL
authors: Kastner
authors: J D
authors: JD
authors: Holloman
authors: G
authors: G
authors: Schmidt-Wolf
authors: A S
authors: AS
authors: Lundberg
authors: A A
authors: AA
authors: Sinha
authors: C
authors: C
authors: Hsu
authors: P
authors: P
authors: Cashin
authors: M G
authors: MG
authors: Molloy
authors: B
authors: B
authors: Mulcahy
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D006684:HLA-DR Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta