title: Inactivation of the macrolide antibiotics erythromycin, midecamycin, and rokitamycin by pathogenic Nocardia species.
abstract: A survey of five Nocardia spp. with respect to susceptibility towards three macrolides (erythromycin, rokitamycin, and midecamycin) showed that the Nocardia spp. have different susceptibility profiles. Most of the resistance was due to the inactivation of the macrolides by phosphorylation, glycosylation, reduction, deacylation, or a combination thereof.
authors: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
authors: K
authors: K
authors: Yazawa
authors: Y
authors: Y
authors: Mikami
authors: T
authors: T
authors: Sakamoto
authors: Y
authors: Y
authors: Ueno
authors: N
authors: N
authors: Morisaki
authors: S
authors: S
authors: Iwasaki
authors: K
authors: K
authors: Furihata
mesh_terms: D001711:Biotransformation; D004917:Erythromycin / Q000493:pharmacokinetics* / Q000494:pharmacology; D006031:Glycosylation; D008658:Inactivation, Metabolic; D007933:Leucomycins / Q000493:pharmacokinetics* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015644:Miocamycin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D009615:Nocardia / Q000187:drug effects* / Q000378:metabolism*; D010084:Oxidation-Reduction; D010766:Phosphorylation
chemical_list: D007933:Leucomycins; D015644:Miocamycin; D004917:Erythromycin; C026483:midecamycin; C033383:rokitamycin