[Oncogenes and tumor suppressor genes in the signal transduction pathways of growth factors].
Growth factors, such as insulin, EGF, PDGF, are indispensable elements of the regulation of cell proliferation. In the last years signal transduction pathways of many growth factors have been elucidated. p21 ras, a proto-oncogene product, plays a central role in growth signalling. The medical importance of the investigation of Ras proteins comes from the fact that mutant forms of Ras genes were found in a number of human tumours. The review summarizes the signal transduction pathways of growth factors, with special respect to the connection of protooncogenes, tumour suppressor genes and cancer research.
Buday
L
L
I. sz. Kémiai-Biokémiai Intézet, Semmelweis Orvostudományi Egyetem, Budapest.
D005809:Genes, Regulator; D016147:Genes, Tumor Suppressor; D011905:Genes, ras; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000502:physiology; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism
D006133:Growth Substances; D007328:Insulin; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011505:Protein-Tyrosine Kinases; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins
Onkogének és tumor szuppresszor gének a növekedési faktorok jelátvivö pályáiban.