title: Vulnerability of conducted vasomotor response to ischemia.
abstract: Many vasoactive substances induce two responses, a direct effect at the site of application and a conducted response that spreads along the vessel length. In the microcirculation, we find that these two components of the vasomotor response display quite different sensitivities to occlusion and/or ischemia. Conducted vasomotor responses were induced in arterioles of the hamster cheek pouch by micropipette application of two test agents: phenylephrine (PE), which causes a receptor-mediated vasomotor response, and KCl, which causes an alteration in the membrane potential by a simple change in the K+ gradient. Ischemia was produced either by total occlusion of the vascular supply, which resulted in a complete cessation of flow in all vessels, or by venous occlusion, which was achieved by gradually inflating a pressurized cuff positioned across the pedicle of the pouch until venous return from the pouch was arrested while the feed arterioles remained patent. Both types of occlusion produced ischemia, the former with low intravascular pressure, the latter with high intravascular pressure. During both types of occlusion, arterioles were initially maximally dilated and unresponsive to both agonists, but over a subsequent 3- to 5-min period, resting arteriolar tone and local responses to both agonists returned. With total occlusion, the conducted response to KCl returned in parallel with the local response, whereas the conducted response to PE was diminished or absent. With venous occlusion, the local responses recovered as with total occlusion, but the conducted responses to both PE and KCl recovered as well.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Molecular Physiology and Biological Physics, School of Medicine, University of Virginia, Charlottesville 22908.
authors: Y
authors: Y
authors: Lin
authors: B R
authors: BR
authors: Duling
mesh_terms: D000818:Animals; D001160:Arterioles / Q000503:physiopathology; D001696:Biomechanical Phenomena; D002610:Cheek / Q000098:blood supply*; D006224:Cricetinae; D015237:Dinoprost / Q000494:pharmacology; D004594:Electrophysiology; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D008647:Mesocricetus; D010656:Phenylephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D010656:Phenylephrine; D011189:Potassium Chloride; D015237:Dinoprost