8;21 and 15;17 translocations: abnormalities in a single cell lineage in acute myeloid leukemia.
We studied lineage involvement in two cases of acute myeloid leukemia (subtypes M2 and M3 expressing translocations 8;21 and variant 15;17, respectively) using the combined immunophenotype and chromosome painting technique known as the MAC (Morphology Antibody Chromosomes) method. We only found the translocations in CD13-positive granulocytic metaphases and not in glycophorin-A-positive erythroid metaphases. These results suggest that the translocations 8;21 and 15;17 only appear in one cell lineage. The karyotype of the cells with a variant 15;17 translocation was 46;XX,der(1)t(1;15)(p?21; q?22)t(1;17)(q?23;q?12),der(15)t(1;15)(q?23;q?22),der(17)t(1;17)(p?21; q?12)/46,XX.
Knuutila
S
S
Department of Medical Genetics, University of Helsinki, Finland.
Majander
P
P
Ruutu
T
T
D000328:Adult; D018826:CD13 Antigens / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic / Q000235:genetics*; D014407:Tumor Cells, Cultured
D018826:CD13 Antigens