Proliferative effects of humoral factors derived from neuroblastoma cells on cultured astrocytes.
The proliferative effects of humoral factors released from N18-RE105 neuroblastoma (NRE) cells on cultured astrocytes were assessed in separate co-culture and conditioned medium studies. In both experimental conditions, the humoral factors derived from neuroblastoma cells had growth-promoting effects on C6 glioma cells of astroglial lineage, but not on primary cultured astrocytes from new-born rat cerebral cortex. It is assumed that neuron-derived humoral factors include astroglial growth factors and that differences in responsiveness between two kinds of cells are probably related to the stages of astroglial maturation processes.
Ohashi
M
M
Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan.
Amano
S
S
Hazama
F
F
Handa
J
J
D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D017077:Culture Media, Conditioned; D051379:Mice; D009447:Neuroblastoma / Q000378:metabolism*; D051381:Rats; D014407:Tumor Cells, Cultured
D017077:Culture Media, Conditioned