[The naloxone-dependent effects of the psychostimulant sidnofen: a study on identified neurons of the snail].
Excitatory and oscillogenic action of psychostimulant sydnophen on identified serotoninergic and peptidergic neurons was shown in the Helix brain. Sydnophen induced marked depolarizing shift, increase of the firing activity, activated excitatory synaptic input and generation of endogenous slow depolarizing potentials and burst activity in these neurons. The effect of sydnophen was blocked by naloxone and was imitated by the agonists of opiate receptors morphine and met-enkephalin. Majority of the other studied identified and non-identified neurons in the Helix brain did not react to sydnophen. Selective naloxone-dependent effect of sydnophen and the possible role of endogenous opioid system in the action of psychotropic agents are discussed.
D'iakonova
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Samonina
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D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004347:Drug Interactions; D017952:Ganglia, Invertebrate / Q000187:drug effects / Q000502:physiology; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008839:Microelectrodes; D009270:Naloxone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018000:Receptors, Peptide / Q000187:drug effects / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D013558:Sydnones / Q000494:pharmacology*
D000928:Antidepressive Agents; D018000:Receptors, Peptide; D011985:Receptors, Serotonin; D013558:Sydnones; C013271:sydnophen; D009270:Naloxone
Naloksonzavisimye éffekty psikhostimuliatora sidnofena: issledovanie na identifitsirovannykh neĭronakh vinogradnoĭ ulitki.