Linkage analysis: progress and problems.
Linkage analysis involves identifying the locations of genes responsible for disease by identifying other genes that co-segregate through families with the risk of disease. Subsequently, molecular approaches are applied to find the precise gene involved. Although these approaches have been successful to date, applications to diseases which do not show clear Mendelian inheritance have presented problems. The nature of these problems is discussed.
Bishop
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DT
ICRF Genetic Epidemiology Laboratory, St James's University Hospital, Leeds, U.K.
D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D005190:Family; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005826:Genetics, Medical; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011336:Probability; D012307:Risk Factors
D005819:Genetic Markers