title: [Comparative study of the effect of antibiotics on the vital activity of plague microbe absorbed by macrophages].
abstract: The influence of aminoglycosides (gentamicin, sisomicin and amikacin), cephalosporins (cefotaxime, ceftazidime and cefazolin) and semisynthetic penicillins (ampicillin and azlocillin) on the vital activity of macrophage-absorbed plague microbe was studied in a model of peritoneal macrophages of albino mice. It was shown that the aminoglycosides and betalactams added to the medium for the cultivation of the macrophages with the absorbed cells of the plaque microbe lowered the intensity of the plague microbe multiplication and promoted the phagocytosis completion when exposed for a prolonged time (24 hours). When the influence was body-mediated (albino mice), even a single administration of the antibiotics was sufficient to retard the vital activity of the macrophage-absorbed plague microbe during the first 6 hours of the observation period. It was also shown that the aminoglycosides were more active than the betalactams.
authors: V A
authors: VA
authors: Zurabian
authors: E I
authors: EI
authors: Markovskaia
authors: G O
authors: GO
authors: Popova
authors: R V
authors: RV
authors: Mikhalevich
authors: L N
authors: LN
authors: Makarovskaia
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D007769:Lactams; D017737:Macrophages, Peritoneal / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology*; D015010:Yersinia pestis / Q000187:drug effects*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007769:Lactams
vernacular_title: Sravnitel'noe izuchenie vliianiia antibiotikov na zhiznedeiatel'nost' chumnogo mikroba, pogloshchennogo makrofagami.