title: The brain tryptophan hydroxylase activity in the sleep-like states in frog.
abstract: The activity of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, was determined in the brain stem in active awake frogs, and frogs in three sleep-like states: with plastic muscle tone (SLS-1), with rigid muscle tone (SLS-2), and with relaxed muscle tone (SLS-3). Significant decrease in the enzyme activity has been found in frogs in SLS-1 and SLS-2 compared to awake animals. The development in frogs a cataleptic-like immobility after treating the animals with rhythmic lighting was accompanied with a decrease in the brain tryptophan hydroxylase activity. These results provide strong evidence for the involvement of the brain serotonin in frogs in the control of evolutionary ancient sleep-like states, probably by the regulation of muscle tone.
authors: Institute of Cytology & Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk.
authors: A V
authors: AV
authors: Kulikov
authors: I G
authors: IG
authors: Karmanova
authors: E Y
authors: EY
authors: Kozlachkova
authors: I P
authors: IP
authors: Voronova
authors: N K
authors: NK
authors: Popova
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002375:Catalepsy / Q000201:enzymology; D006990:Hypnosis; D009129:Muscle Tonus / Q000502:physiology; D011895:Rana ridibunda; D012890:Sleep / Q000502:physiology*; D014365:Tryptophan Hydroxylase / Q000378:metabolism*; D014851:Wakefulness / Q000502:physiology
chemical_list: D014365:Tryptophan Hydroxylase