Ab-Ag affinity thresholds in inventory optimization.
The role of antibody-antigen affinity and concentrations in adaptive antibody response is analyzed in a framework of probabilistic inventory model for antibody production. Our results indicate significant differences in optimal behaviours of low, moderate and high affinity groups and offer important implications. Interestingly, the involved approach is also of relevance in other production systems. Directions for its applications in industries and information sciences are also presented.
Joshi
R R
RR
Department of Mathematics, Indian Institute of Technology, Powai, Bombay.
D000818:Animals; D000915:Antibody Affinity / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology; D018448:Models, Immunological; D017711:Nonlinear Dynamics; D011336:Probability