The effect of space and parabolic flight on macrophage hematopoiesis and function.
We used weak electric fields to monitor macrophage spreading in microgravity. Using this technique, we demonstrated that bone marrow-derived macrophages responded to microgravity within 8 s. We also showed that microgravity differentially altered two processes associated with bone marrow-derived macrophage development. Spaceflight enhanced cellular proliferation and inhibited differentiation. These data indicate that the space/microgravity environment significantly affects macrophages.
Armstrong
J W
JW
Division of Biology, Kansas State University, Manhattan 66506-4901.
Gerren
R A
RA
Chapes
S K
SK
D000818:Animals; D000943:Antigens, Differentiation / Q000096:biosynthesis; D001853:Bone Marrow / Q000276:immunology*; D002448:Cell Adhesion; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement; D037502:Galectin 3; D006410:Hematopoiesis / Q000187:drug effects; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D007376:Interleukin-2 / Q000494:pharmacology; D015850:Interleukin-6 / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000502:physiology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013026:Space Flight; D013696:Temperature; D014893:Weightlessness
D000943:Antigens, Differentiation; D037502:Galectin 3; D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2; D015850:Interleukin-6