Use of topical diclofenac in association with external ocular compression.
This study investigated the effect of pretreatment with topical diclofenac 0.1% on the changes in intraocular pressure (IOP) associated with use of an external ocular compression device. The IOP reduction in eyes receiving pretreatment was significantly greater than in controls after 40 minutes of compression, and the recovery in IOP after removal of the compression device was significantly reduced. We conclude that the IOP rise after such compression is largely prostaglandin mediated, and suggest that use of ocular compression devices is associated with marked intraocular prostaglandin release.
Constable
P H
PH
Oldchurch Hospital, Romford, Essex, UK.
Adams
G G
GG
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008875:Middle Aged; D011312:Pressure; D013997:Time Factors
D004008:Diclofenac