title: Acute pneumonitis presumed to be silicone embolism.
abstract: A 39-year-old housewife who underwent intramammary injections of a proprietary silicone fluid mixture showed clinical and novel transbronchial lung biopsy (TBLB) findings. She presented with complaints of progressive dyspnea, dry cough, and pleuritic chest pain 2 days after the last silicone injections. The chest X-ray and CT scan showed diffuse interstitial infiltrates. TBLB demonstrated translucent, presumably silicone globules embolized within the pulmonary capillaries. The documentation of intramammary injections, the clinical and radiographic features of acute pneumonitis, and the histopathologic evidence by TBLB, may support the causal relationship between illicit injections and the silicone embolism. We discuss the pathogenesis and urge that this potentially toxic source of pulmonary embolism be removed.
authors: Department of Medicine, Okinawa Chubu Hospital.
authors: T
authors: T
authors: Matsuba
authors: T
authors: T
authors: Sujiura
authors: M
authors: M
authors: Irei
authors: Y
authors: Y
authors: Kyan
authors: N
authors: N
authors: Kunishima
authors: H
authors: H
authors: Uchima
authors: S
authors: S
authors: Miyagi
authors: Y
authors: Y
authors: Iwata
authors: K
authors: K
authors: Matsuba
mesh_terms: D000208:Acute Disease; D000328:Adult; D018427:Breast Implants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D011859:Radiography; D012828:Silicones / Q000009:adverse effects*
chemical_list: D012828:Silicones