Lymphoproliferative disorders in non-AIDS-associated Kaposi's sarcoma. The Johannesburg Hospital experience, 1980-1992.
The association of the non-AIDS-related, classic form of Kaposi's sarcoma (KS) with secondary malignancies, especially lymphoproliferative disorders, has frequently been noted. However, in endemic African-type KS, such an association has been reported only rarely. A review of 62 non-AIDS-related cases of KS treated and followed up at Johannesburg General Hospital between 1980 and 1992 revealed 8 patients (13%) in whom KS was associated with malignant lymphoproliferative disorders. The prevalence of secondary lymphoproliferative disorders was not significantly different among patients with classic KS (3/15; 20%) when compared with those who had African KS (4/47; 8%). In both forms of KS subtle disturbances of immunity have been described which may play a role in the pathogenesis of secondary lymphoproliferative disorders, although the factors responsible and the pathogenetic mechanisms involved in malignant lymphoid transformation in these patients have not been fully elucidated.
Stein
M E
ME
Department of Medical Oncology and Haematology, Johannesburg Hospital.
Spencer
D
D
Dansey
R
R
Perner
Y
Y
Gunther
K
K
Bezwoda
W R
WR
D000328:Adult; D000368:Aged; D005871:Castleman Disease / Q000150:complications; D018450:Disease Progression; D005260:Female; D006689:Hodgkin Disease / Q000150:complications; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008258:Waldenstrom Macroglobulinemia / Q000150:complications