title: Influence of an antioxidant on the impulse activity of neurons of the prefrontal and inferotemporal cortex during visual recognition in monkeys.
abstract: The impulse activity of individual neurons of the prefrontal and inferotemporal cortex was recorded during the performance of a task of delayed visual differentiation of stimuli of various colors in monkeys before and after the systemic administration of the antioxidant, oxymethacil (4-5 mg/kg). The improvement in cognitive characteristics induced by oxymethacil was accompanied by changes in the activity of neurons of the prefrontal cortex in which activation dependant upon the stage of recognition and intensifying during an increase in the duration of the delay predominated. Inhibition of activity predominated during recognition without delay in these neurons; by contrast, activation predominated in neurons of the inferotemporal cortex under these conditions. During delayed differentiation, the activity of these neurons under the influence of oxymethacil changed principally in the same way as in neurons of the prefrontal cortex: activation predominated in the majority of the stages of recognition. Oxymethacil induced a substantial increase in the coefficients of cross correlation between simultaneous respondent reactions of groups of neurons in these different areas of the cortex. The results obtained attest to the contribution of neuronal structures of the prefrontal and inferotemporal cortex to the improvement of cognitive characteristics of monkeys in the presence of the effect of oxymethacil, and to the increase in synchronization of informational processes in these regions of the cortex.
authors: Laboratory of the Regulation of the Functions of Brain Neurons, I. P Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg.
authors: K N
authors: KN
authors: Dudkin
authors: V K
authors: VK
authors: Kruchinin
authors: I V
authors: IV
authors: Chueva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003116:Color; D007273:Injections, Intramuscular; D008253:Macaca mulatta; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000166:cytology* / Q000187:drug effects; D013702:Temporal Lobe / Q000166:cytology* / Q000187:drug effects; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D014498:Uracil; C003029:oxymethacil