[Production of elastase, exotoxin A and alkaline protease during bronchopulmonary exacerbations in patients with mucoviscidosis chronically infected by Pseudomonas aeruginosa].
The authors have studied the production of exoproteins by Pseudomonas aeruginosa in the sputa of 18 patients suffering from cystic fibrosis, during 29 bronchopulmonary exacerbations and also after the recovery of a stable state. Significant levels of exoproteins were detected but with a large heterogenity of intra and inter individual variations. A significant decrease in the production of the three exoproteins was found after twelve days of antibiotherapy, without any correlation between exoprotein levels and colony forming units in the sputa. During the intercrisis phase, exoproteins levels were practically undetectable. These facts and the good correlation between clinical symptoms support the hypothesis of a renewal of virulence of Pseudomonas aeruginosa during these periods of bronchopulmonary exacerbation in cystic fibrosis.
Jaffar-Bandjee
M C
MC
Laboratoire de Biologie, Hôpital R. Sabran, Hyères, France.
Carrere
J
J
Bally
M
M
Chazalette
J P
JP
Galabert
C
C
D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology*; D005098:Exotoxins / Q000302:isolation & purification*; D006801:Humans; D011552:Pseudomonas Infections / Q000150:complications*; D011550:Pseudomonas aeruginosa / Q000201:enzymology / Q000302:isolation & purification / Q000378:metabolism*; D013183:Sputum / Q000737:chemistry*
D005098:Exotoxins
Production d'élastase, exotoxine A et protéase alcaline au cours des exacerbations bronchopulmonaires chez les patients mucoviscidosiques porteurs chroniques de Pseudomonas aeruginosa.