Teleocidins and benzolactams inhibit cell killing by human immunodeficiency virus type 1 (HIV-1).
Teleocidin B-4 and structurally related synthetic benzolactams were found to be potent inhibitors of cell killing by HIV-1. One of the benzolactams, (-)-BL-V8-310, showed a high selectivity index.
Endo
Y
Y
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Ohno
M
M
Hirano
M
M
Fujiwara
T
T
Sato
A
A
Hinuma
Y
Y
Shudo
K
K
D000998:Antiviral Agents / Q000494:pharmacology*; D004396:Coloring Agents; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007509:Irritants / Q000494:pharmacology*; D008235:Lyngbya Toxins / Q000494:pharmacology*; D013778:Tetrazolium Salts; D013844:Thiazoles; D014779:Virus Replication / Q000187:drug effects; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D004396:Coloring Agents; D007509:Irritants; D008235:Lyngbya Toxins; D013778:Tetrazolium Salts; D013844:Thiazoles; C022176:teleocidins; C022616:thiazolyl blue