[Multiple endocrine neoplasia type I. Review and presentation of the study group of multiple endocrine neoplasia type I (GENEM I)].
Multiple endocrine neoplasia type I, also known as Wermer's syndrome, is characterized by the presence of functioning or nonfunctioning tumors or hyperplasia of the parathyroid glands, pancreatic islet cells and pituitary gland. MEN I syndrome may be either familial or sporadic. MEN I locus has recently been mapped to chromosome 11, and further characterization of the abnormal gene appears imminent. The GENEM I, a multidisciplinary study group is in the process of formation. Pathologists have to specify the morphological criteria of hyperplasia vs tumor. Further characterization of the gene and its product requires the application of molecular biology methods to the pathologic tissues of these patients.
Saint-André
J P
JP
Laboratoire d'Anatomie Pathologique, CHU, Angers.
Berger-Dutrieux
N
N
Le Bodic
M F
MF
de Micco
C
C
Trouillas
J
J
D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000473:pathology; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000235:genetics / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology*; D010282:Parathyroid Neoplasms / Q000235:genetics / Q000473:pathology*; D010903:Pituitary Gland, Anterior / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000235:genetics / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology
Les néoplasies endocriniennes multiples de type I. Mise au point et présentation du groupe d'étude des néoplasies endocriniennes multiples de type I (GENEM I).