Suppression of acute inflammation with liposome associated prostaglandin E1.
Prostaglandin E1 (PGE1) suppresses leucocyte effector function and reduces inflammation in several animal models of acute and chronic inflammation. A drawback to its use as a therapeutic agent is the relatively high doses needed to suppress inflammation. We present evidence in this report that liposome associated PGE1 (LAP) reduces markedly acute inflammation induced in a subcutaneous air pouch by monosodium urate crystals, and by the polypeptide mediators, interleukin 1-beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha). A single dose of 12 micrograms/kg LAP given intravenously 2 hr after inflammation was induced, reduced accumulation of cells and exudate by 31-49%.
Rossetti
R G
RG
Department of Medicine, University of Massachusetts Medical Center, Worcester 01655.
Brathwaite
K
K
Zurier
R B
RB
D000208:Acute Disease; D000818:Animals; D015232:Dinoprostone / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy*; D007375:Interleukin-1 / Q000502:physiology; D008081:Liposomes; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D007375:Interleukin-1; D008081:Liposomes; D014409:Tumor Necrosis Factor-alpha; D015232:Dinoprostone