Protective effects of serum thymic factor to Leptospira interrogans serovar Copenhageni infection in Mongolian gerbils.
The susceptibility to Leptospira interrogans serovar copenhageni in Mongolian gerbils treated with 10 micrograms of serum thymic factor (FTS) 1 day before infection was examined. Susceptibility of gerbils treated 5 times with 10 micrograms of FTS was also investigated. Mortality of FTS-treated gerbils was significantly lower than that of controls when small challenge doses were used. To analyse the FTS-induced resistance to leptospiral infection, natural killer (NK) cell activity and macrophage activity were studied. Macrophage activity was unaltered but NK cell activity was enhanced in FTS-treated gerbils, with or without leptospiral infection. Since no side-effects of FTS were observed, this compound should be considered for the treatment of leptospirosis.
Yukawa
M
M
Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan.
Mochizuki
K
K
Kosaka
T
T
Kamata
H
H
Awaya
A
A
Kobayashi
H
H
Onodera
T
T
D000818:Animals; D004195:Disease Models, Animal; D005849:Gerbillinae; D007694:Killer Cells, Natural / Q000276:immunology; D007921:Leptospira interrogans / Q000145:classification / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D012703:Serotyping; D013935:Thymic Factor, Circulating / Q000008:administration & dosage / Q000494:pharmacology*; D014895:Weil Disease / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*
D013935:Thymic Factor, Circulating