title: Transforming growth factor-beta (TGF-beta) and articular chondrocytes.
abstract: Transforming growth factor-beta (TGF-beta) has a dual effect on the proliferation of joint chondrocytes. In medium with a low serum concentration, it inhibits cell growth, while in medium supplemented with 10% fetal calf serum it stimulates cell growth. This stimulation leads to a higher replication rate an a larger number of cells in the G2/M phase of the cell cycle. Since these cells have already replicated their DNA, they can begin mitosis when stimulated by a EGF type factor. This mechanism involves the systems of the TGF-beta receptors which appear to vary with the cell cycle. In addition, a glycane inositophosphate may play a role as a second messenger for TGG-beta in this action. Finally, TGF-beta cannot restore the chondrocyte phenotype in dedifferentiated cells nor limit the dedifferentiation process. It exerts a opposing effect to the deleterious effects of interleukin-1 by inhibiting the expression of the receptors of this cytokine at the level of transcription. These in vitro effects would suggest that TGF-beta plays an important role in the repair potentiality of joint cartilage especially in arthrosis. In vivo studies are however necessary to verify this hypothesis.
authors: Laboratoire de Biochimie du Tissu Conjonctif (CJF INSERM 91-06), CHU Côte de Nacre, Caen.
authors: J P
authors: JP
authors: Pujol
authors: P
authors: P
authors: Galera
authors: S
authors: S
authors: Pronost
authors: K
authors: K
authors: Boumediene
authors: D
authors: D
authors: Vivien
authors: M
authors: M
authors: Macro
authors: W
authors: W
authors: Min
authors: F
authors: F
authors: Redini
authors: H
authors: H
authors: Penfornis
authors: M
authors: M
authors: Daireaux
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology*; D002455:Cell Division / Q000187:drug effects; D005109:Extracellular Matrix / Q000378:metabolism; D016195:G2 Phase; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D011817:Rabbits; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
chemical_list: D007375:Interleukin-1; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta