title: [Paraplegia associated with HTLV 1 in Martinique. Study of 271 cases including 70 with neuromuscular involvement].
abstract: To date, 271 cases of HTLV1-associated paraplegia have been observed in Martinique (French West Indies). The clinical picture consisted mostly in a spastic paraparesis or paraplegia with sphincter disturbances (80%) and lower limbs pains (60%). The severity of the disease appeared variable: after a mean disease duration of 6.5 years, 40% of the patients could walk without help, 35% used a single crutch, and 25% used a couple of crutches or were confined to a wheelchair. A variable neuromuscular component was observed in 70 cases (25.4%). In 38 cases, the peripheral signs (SIGNS) or the myositis were only mild. In contrast, 25 patients presented with severe amyotrophy evoking amyotrophic lateral sclerosis, and 7 other had features of dermatopolymyositis. Lastly, an extra-neural spreading of the disease was extremely frequent, including lymphocytic alveolitis (76%), sicca syndrome (69%) and more rarely uveitis, arthritis or vasculitis.
authors: Service de neurologie, Hôpital Pierre Zobda-Quitman, Fort-de-France.
authors: D
authors: D
authors: Smadja
authors: P
authors: P
authors: Cabre
authors: R
authors: R
authors: Bellance
authors: J C
authors: JC
authors: Vernant
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008297:Male; D008395:Martinique; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology
vernacular_title: Paraplégie associée à l'HTLV1 en Martinique. Etude de 271 cas dont 70 avec atteinte neuromusculaire.