title: Optimization of the analytical performance of the magnetic sector mass spectrometer for the identification of residual chloramphenicol in shrimp.
abstract: Chemical noise limits mass spectrometric detection of chloramphenicol (CAP) with electron capture ionization at low resolution, and makes CAP identification at concentrations of 5 parts per billion (ppb) difficult. Increasing the resolution from 1000 to 3500, however, was sufficient to separate the analyte signals from the noise signals, and resulted in a 100 times higher analytical sensitivity. The introduction of sweep gas in the ion source decreased the scattering of the quantitative results on average by a factor of 7, and thereby improved the precision of the analyses to an acceptable level (CV < 10%). Under such conditions, CAP residues of 1.5 and 2.1 ppb in shrimp as determined by electron capture gas chromatography/mass spectrometry can readily be identified by monitoring four diagnostic ions.
authors: Gulf Coast Seafood Laboratory, US Food and Drug Administration, Dauphin Island, AL 36528.
authors: F A
authors: FA
authors: Bencsath
authors: S M
authors: SM
authors: Plakas
authors: A R
authors: AR
authors: Long
mesh_terms: D000818:Animals; D002701:Chloramphenicol / Q000032:analysis*; D033364:Decapoda / Q000737:chemistry*; D004350:Drug Residues / Q000032:analysis*; D013058:Mass Spectrometry
chemical_list: D002701:Chloramphenicol