title: 5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment.
abstract: The synthesis of some arylpiperazines with a benzamide moiety on N-4 alkyl chain was accomplished and their dopaminergic and serotonergic affinity was assayed by in vitro receptor binding. The results of such investigation showed a moderate affinity on D-2 receptors and a lack of 5-HT receptor affinity.
authors: Dipartimento Farmaco-Chimico, Bari, Italy.
authors: R
authors: R
authors: Perrone
authors: F
authors: F
authors: Berardi
authors: M
authors: M
authors: Leopoldo
authors: V
authors: V
authors: Tortorella
authors: M D
authors: MD
authors: Lograno
authors: E
authors: E
authors: Daniele
authors: S
authors: S
authors: Govoni
mesh_terms: D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism
chemical_list: D001549:Benzamides; D010879:Piperazines; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin