Fibrinolytic and thrombotic factors in atherosclerosis and IHD: the influence of triglyceride rich lipoproteins (TGRLP).
TGRLP interactions with the endothelium may increase the likelihood that a suppressed fibrinolytic capacity and/or an increased procoagulant activity enhances the risk for an ischemic event, that is, for the production of a focal thrombus. The cellular mechanisms and characteristics of TGRLP in hyperlipemia and in the postprandial state that contribute to their potential pathology in IHD are considered.
Bradley
W A
WA
University of Alabama, Department of Medicine, Birmingham.
Booyse
F M
FM
Gianturco
S H
SH
D001161:Arteriosclerosis / Q000097:blood / Q000503:physiopathology*; D001779:Blood Coagulation Factors / Q000502:physiology*; D002914:Chylomicrons / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology; D005342:Fibrinolysis; D006801:Humans; D008079:Lipoproteins, VLDL / Q000502:physiology*; D017202:Myocardial Ischemia / Q000097:blood / Q000503:physiopathology*; D018110:Receptors, Lipoprotein / Q000502:physiology; D013927:Thrombosis / Q000150:complications / Q000503:physiopathology; D014280:Triglycerides / Q000502:physiology*
D001779:Blood Coagulation Factors; D002914:Chylomicrons; D008079:Lipoproteins, VLDL; D018110:Receptors, Lipoprotein; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride