Modulation of growth factor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant, which causes a variety of toxic effects including alterations in cell growth and differentiation. In the last years it became increasingly evident that growth factors and their corresponding receptors are involved in toxic responses of this compound. The interference of TCDD with growth factor expression has been studied in several in vitro and in vivo systems. Here, we give a short summary of the published data about interactions between TCDD and growth factors.
Döhr
O
O
Department of Toxicology, Heinrich Heine University of Düsseldorf, Germany.
Vogel
C
C
Abel
J
J
D000818:Animals; D004815:Epidermal Growth Factor / Q000096:biosynthesis; D006133:Growth Substances / Q000096:biosynthesis*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D018336:Receptors, Aryl Hydrocarbon / Q000187:drug effects / Q000502:physiology; D016211:Transforming Growth Factor alpha / Q000096:biosynthesis; D016212:Transforming Growth Factor beta / Q000096:biosynthesis; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D006133:Growth Substances; D007375:Interleukin-1; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D016211:Transforming Growth Factor alpha; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D004815:Epidermal Growth Factor