Aluminum toxicity in rat hippocampal neurons.
A brief exposure of dissociated hippocampal culture to aluminum (AlCl3, 60 min) is toxic to neurons. The aluminum toxicity is independent of calcium or glutamate receptor activation. However, at a high concentration (1 mM), aluminum seems to have a protective effect.
Brenner
S R
SR
Department of Neurology, Saint Louis University Health Science Center, MO 63110-0250.
Yoon
K W
KW
D000535:Aluminum / Q000008:administration & dosage / Q000494:pharmacology / Q000506:poisoning*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D016923:Cell Death; D002478:Cells, Cultured; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005110:Extracellular Space / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology; D011190:Potassium Cyanide / Q000506:poisoning; D051381:Rats; D013997:Time Factors
D018696:Neuroprotective Agents; D016291:Dizocilpine Maleate; D000535:Aluminum; D011190:Potassium Cyanide; D002118:Calcium