[First experience in the use of a new Russian narcotic analgesic prosidol in oncology].
Prosidol, a new Russian narcotic analgesic, was used in various dosage forms (buccal and oral tablets, injection solution) in 113 cancer patients for the treatment of chronic pain, as a component of total anesthesia, and for postoperative analgesia. The best results were attained with the universal noninvasive dosage form, buccal tablets, used for the treatment of chronic pain in incurable patients. Analgesic properties of buccal prosidol are close to those of tramadol, the drug is well tolerated by the patients and causes no grave side effects. As a drug for postoperative analgesia prosidol was highly effective in patients after extracavitary oncologic surgery and less effective after thoracal and abdominal interventions. As a component of total anesthesia prosidol is inferior to fentanyl and approximately similar to promedol. An advantage of prosidol is its highly effective universal noninvasive dosage form, buccal tablets, which may be used for rapid analgesia in any situation.
Osipova
N A
NA
Novikov
G A
GA
Vetsheva
M S
MS
Prokhorov
B M
BM
Beresnev
V A
VA
Loseva
N A
NA
Zemskaia
S Iu
SIu
Smolina
T A
TA
D000278:Administration, Buccal; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D000758:Anesthesia; D002908:Chronic Disease; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010149:Postoperative Pain / Q000188:drug therapy; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D011396:Promedol / Q000008:administration & dosage / Q000627:therapeutic use; D014147:Tramadol / Q000008:administration & dosage / Q000627:therapeutic use
D000701:Analgesics, Opioid; D010880:Piperidines; C091183:prosidol; D014147:Tramadol; D011396:Promedol; D005283:Fentanyl
Pervyĭ opyt primeneniia novogo otechestvennogo narkoticheskogo analgetika prosidola v onkologii.