Chondroitin sulfate proteoglycans are a common component of neuronal inclusions and astrocytic reaction in neurodegenerative diseases.
Previously, we showed three differentially sulfated forms of chondroitin sulfate proteoglycans (CSPG) associated with senile plaques, astrocytes and neurofibrillary tangles in Alzheimer's disease. Here, monoclonal antibodies were used to demonstrate CSPGs in other neurodegenerative diseases. CSPGs were found associated with inclusions of Parkinson's, diffuse Lewy body, Pick's diseases, and progressive supranuclear palsy. Reacting astrocytes in each of these neurodegenerative diseases and Huntington's disease showed immunoreactivity for CSPG. CSPG distribution in a variety of neurodegenerative diseases suggests that similar mechanisms may be involved in the accumulation of proteoglycans in a number of filamentous inclusions.
DeWitt
D A
DA
Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106.
Richey
P L
PL
Praprotnik
D
D
Silver
J
J
Perry
G
G
D000368:Aged; D000369:Aged, 80 and over; D001253:Astrocytes / Q000737:chemistry*; D011508:Chondroitin Sulfate Proteoglycans / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D002479:Inclusion Bodies / Q000737:chemistry*; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000737:chemistry*
D011508:Chondroitin Sulfate Proteoglycans