Acute myeloid leukaemia with +i(12p) shortly after treatment of mediastinal germ cell tumour.
We report a patient who developed acute myeloid leukaemia (M2) shortly after successful treatment of a mediastinal germ cell tumour. The leukaemia was preceded by a documented myelodysplastic phase. Complex cytogenetic abnormalities were found in bone marrow and peripheral blood cells including +i(12p), typical of germ cell malignancy. Fluorescence in situ hybridization revealed the presence of +i(12p) in myeloblasts, erythroblasts and neutrophils but not in lymphocytes. This case provides further evidence for a common clonal origin of haematological malignancies and mediastinal germ cell tumours.
Vlasveld
L T
LT
Department of Haematology, Erasmus University, Rotterdam, The Netherlands.
Splinter
T A
TA
Hagemeijer
A
A
Van Lom
K
K
Löwenberg
B
B
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018236:Carcinoma, Embryonal / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D002999:Clone Cells; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018404:Isochromosomes; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D016609:Neoplasms, Second Primary