title: Concordance of smooth pursuit and saccadic measures in normal monozygotic twin pairs.
abstract: Although the range of normal ocular motor performance is broad, little is known about the sources of variability. Genetic transmission of eye movement deficits has been described but such possible control of normal function has been little investigated. Characteristics of smooth pursuit and saccades can be examined for the degree of concordance in related individuals. In this pilot study, we studied saccades and pursuit in eight monozygotic (MZ) twin pairs. The statistical analysis of the data used the intraclass correlation of MZ twins (rMZ) to estimate what fraction the covariance of the twin pairs was of the population variance. All saccadic measures showed significant MZ correlations (p < 0.05). Smooth pursuit gains were even more highly correlated (p < 0.001). These results indicate considerable similarity within pairs of twins, particularly for horizontal smooth pursuit, and suggest that larger studies on monozygotic and dizygotic twins would be desirable, to help separate out the relative contributions of environmental and genetic factors.
authors: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis.
authors: B B
authors: BB
authors: Bell
authors: L A
authors: LA
authors: Abel
authors: W
authors: W
authors: Li
authors: J C
authors: JC
authors: Christian
authors: R D
authors: RD
authors: Yee
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype; D010865:Pilot Projects; D011698:Pursuit, Smooth / Q000235:genetics*; D012438:Saccades / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*