title: A Canadian multicentre placebo-controlled study of a fixed dose of brofaromine, a reversible selective MAO-A inhibitor, in the treatment of major depression.
abstract: In a 6-week double-blind study, 220 patients with major depression (mostly outpatients) were randomly assigned to receive a fixed dose of brofaromine 150 mg daily (n = 111) or placebo (n = 109) after a 1-week single-blind placebo washout. Except for the HAM-D sleep items, brofaromine was superior to placebo on measures of depression as determined by the four methods of assessing drug efficacy: (1) psychiatric symptom rating (HAM-D 17-item less the three sleep items); (2) self-rating scale (Beck Depression Inventory); (3) Clinical Global Assessment of Efficacy; and (4) drop-out rate due to lack of efficacy. Most commonly reported adverse events with brofaromine were: headache, nausea, dizziness and sleep disturbance. Brofaromine was found to be an effective antidepressant, superior to placebo with a good tolerability profile.
authors: Hôpital Louis-H. Lafontaine, Montréal, Québec, Canada.
authors: G
authors: G
authors: Chouinard
authors: B M
authors: BM
authors: Saxena
authors: N P
authors: NP
authors: Nair
authors: S P
authors: SP
authors: Kutcher
authors: D
authors: D
authors: Bakish
authors: J
authors: J
authors: Bradwejn
authors: S H
authors: SH
authors: Kennedy
authors: V
authors: V
authors: Sharma
authors: R A
authors: RA
authors: Remick
authors: S A
authors: SA
authors: Kukha-Mohamad
mesh_terms: D000293:Adolescent; D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D010555:Personality Inventory; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; C038213:brofaromine