Look-back study of infectivity of anti-HCV ELISA-positive blood components.
The infectivity of blood components from donors who were later found to be anti-HCV ELISA-positive was investigated in recipients who were enrolled in a look-back programme. Recipients received ELISA-positive blood components from donors who were PCR-positive and/or RIBA-2-positive (n = 22, group A) or PCR-negative and indeterminate or negative on RIBA-2 (n = 105, group B). 26 of 32 (81%) recipients of group A donors and none of 140 of group B were HCV-infected. All stored serum samples of previous donations (n = 172) of group A donors were anti-HCV-positive in RIBA-3, indicating a chronic carrier state of HCV in these donors.
Vrielink
H
H
Red Cross Blood Bank, Amsterdam, Netherlands.
van der Poel
C L
CL
Reesink
H W
HW
Zaaijer
H L
HL
Scholten
E
E
Kremer
L C
LC
Cuypers
H T
HT
Lelie
P N
PN
van Oers
M H
MH
D001782:Blood Donors; D016358:Contact Tracing; D004797:Enzyme-Linked Immunosorbent Assay; D006526:Hepatitis C / Q000175:diagnosis* / Q000635:transmission*; D006801:Humans; D015151:Immunoblotting; D016133:Polymerase Chain Reaction; D065227:Transfusion Reaction