title: A distinct coagulopathy associated with interleukin-2 therapy.
abstract: We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL-2). A 43% prolongation of the PTT (P < 0.001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL-2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII, VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.
authors: Montefiore Medical Center, Bronx, New York 10467.
authors: L
authors: L
authors: Oleksowicz
authors: M
authors: M
authors: Strack
authors: J P
authors: JP
authors: Dutcher
authors: I
authors: I
authors: Sussman
authors: G
authors: G
authors: Caliendo
authors: J
authors: J
authors: Sparano
authors: P H
authors: PH
authors: Wiernik
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology*; D001779:Blood Coagulation Factors / Q000032:analysis; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D009369:Neoplasms / Q000097:blood / Q000628:therapy; D010314:Partial Thromboplastin Time; D011446:Prospective Studies
chemical_list: D001779:Blood Coagulation Factors; D007376:Interleukin-2