title: Cytogenetic abnormalities in B-immunoblastic lymphoma.
abstract: We have considered the cytogenetic abnormalities present in 27 unpublished cases of B-immunoblastic lymphoma. Among these 27 patients, the chromosome changes were heterogeneous and complex. The chromosomes most commonly gained were 3 (44% of cases), 18 (44%), 6 (30%) and 11 (30%). The most common structural abnormalities involved band 14q32 (26%), band 18q21 (15%) and bands 6q16-21 (19%). Study of these 27 immunoblastic lymphomas did not allow us to tentatively identify a common primary cytogenetic abnormality unique to B-immunoblastic lymphoma, however, a translocation at 14q32 may be the primary cytogenetic lesion in some of the cases. Rather, we have added to the number of abnormalities reported in immunoblastic lymphoma and in non-Hodgkin's lymphoma in general.
authors: Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198-5440.
authors: M B
authors: MB
authors: Nashelsky
authors: M M
authors: MM
authors: Hess
authors: D D
authors: DD
authors: Weisenburger
authors: J L
authors: JL
authors: Pierson
authors: M A
authors: MA
authors: Bast
authors: J O
authors: JO
authors: Armitage
authors: W G
authors: WG
authors: Sanger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*