[Optimal induction and maintenance of the hypertensive state an important factor in clinical advantages of angiotensin II induced hypertension chemotherapy (IHC)].
Angiotensin II induced hypertension chemotherapy (IHC) is a drug delivery system in which the functional difference of microcirculation between tumor and normal tissue was applied. IHC records of the patients with advanced gastrointestinal cancer, admitted in our hospitals were analysed according to the patterns of the maintenance level and range of blood pressure. Those who were possible to get ambulatory life had significantly good response and long survival in addition to better performance status before IHC, comparing with those who had continued admission life. An optimal range of elevation level and stable maintenance of hypertension induced by the infusion of angiotensin II was essentially required to obtain a good response.
Sato
H
H
Institute of Aging, Development and Cancer, Tohoku University.
Hoshi
M
M
Sugiyama
K
K
Urushiyama
M
M
Ishizuka
K
K
D000804:Angiotensin II / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D003131:Combined Modality Therapy; D016503:Drug Delivery Systems; D005770:Gastrointestinal Neoplasms / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D000804:Angiotensin II