Thrombotic thrombocytopenic purpura: a rare late complication of allogeneic bone marrow transplantation.
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) usually occurs in a setting of systemic infection or graft-versus-host reaction during the first weeks following transplant. We report a case of fatal TTP that developed eight months after allogeneic bone marrow transplantation (BMT) without any evident association with other transplantation-related complications. Conditioning chemotherapy could have induced the disorder by causing damage to the vascular endothelium. The removal of immunosuppression, including cessation of cyclosporin A (CyA), may have precipitated the disease.
Pucci
G
G
Department of Hematology, OORR, Reggio Calabria, Italy.
Martino
M
M
Morabito
F
F
Iacopino
P
P
Arcese
W
W
Iori
A P
AP
Lombardo
V T
VT
L'Abbate
A
A
Santostefano
M
M
Nobile
F
F
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology*; D014184:Transplantation, Homologous