Clinical value of soluble interleukin-2 receptor in infectious complications.
In this study, we investigated serum-soluble interleukin-2 receptor (sIL-2r) and neopterin (NPT) levels in five patients with severe postoperative infections. A total of 25 synchronous determinations of sIL-2r and NPT were performed. A marked increase in sIL-2r and NPT levels was observed, and the increase in sIL-2r was significantly correlated to that of NPT which is a marker of macrophage activity. These results suggest that macrophages are involved in the stimulation of sIL-2r release, representing a potentially negative biological effect. The results indicate that sIL-2r may be a useful indicator of the efficacy of antibiotics and of prognosis.
Iwagaki
H
H
First Department of Surgery, Okayama University Medical School, Japan.
Hizuta
A
A
Iwadou
H
H
Perdomo
J A
JA
Tanaka
N
N
Orita
K
K
D000368:Aged; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D010538:Peritonitis / Q000097:blood*; D011014:Pneumonia / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood*; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D015375:Receptors, Interleukin-2; D001708:Biopterins; D019798:Neopterin