Enhanced expression of catalytic subunits of protein phosphatase type 1 and high S-phase fraction in liposarcoma.
The expression of the three catalytic subunits of protein phosphatase (PP) type 1 and 2A, PP1 alpha, PP1 gamma 1, and PP2AC, was examined in 8 cases of lipoma as a benign tumor and 4 cases of liposarcoma as a malignant tumor using immunohistochemical analysis. Both types of of tumor cells stained positively with antisera against PP1 catalytic subunit isoforms PP1 alpha and PP1 gamma 1 were significantly higher in liposarcoma than in lipoma. Furthermore, liposarcoma showed a markedly high S-phase fraction in the cell cycle of tumor cells, as compared with lipoma. These results suggest that PP1 is involved in the accelerated growth of malignant cells in liposarcoma.
Sogawa
K
K
Department of Pathology, Kagawa Medical School, Japan.
Yamada
T
T
Masaki
T
T
Nishikawa
H
H
Cai
Y
Y
Oka
S
S
Norimatsu
H
H
Matsumoto
K
K
D000328:Adult; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D008067:Lipoma / Q000201:enzymology* / Q000473:pathology; D008080:Liposarcoma / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D016196:S Phase
D004273:DNA, Neoplasm; D010749:Phosphoprotein Phosphatases