[Critical review of theories on cell aging. From Hayflick's basis concept to the concept of critical threshold of accumulation of errors].
The goal of this review of the theories of cellular ageing is first to distinguish the theories on the basis of logical criteria following the dichotomies genetic/environmental and deterministic/stochastic. The second purpose is to show, from such criteria, that these theories can be integrated in a more general concept, which is the concept of critical threshold of error accumulation, taking into account the protective role of defenses systems avoiding a quick increase in the level of intracellular errors.
Toussaint
O
O
Laboratoire de Biochimie Cellulaire, Facultés Universitaires N.-D. de la Paix, Namur, Belgique.
Remacle
J
J
D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D006801:Humans
Revue critique des théories du vieillissement cellulaire. Du concept de base de Hayflick au concept de seuil critique d'accumulation d'erreurs.