Synthesis and antiulcer activity of some (1S, 5R)-2-thiabicyclo (3, 3, 0) oct-5-ene derivatives.
The preparation of (1S,5R)-2-Thiabicyclo[3,3,0]oct-6-ene derivatives (Sn;n=0,1,2) is described. Spectral and optical data (IR, NMR, Mass, alphaD20) are reported. These compounds can be considered as thiaprostacyclin-like derivatives. Studies of anti-ulcer activity in comparison with two reference compounds (cimetidine, pirenzipine) have shown that all the new compounds own a good anti-ulcer activity. Further studies are in progress to establish the mechanisms of their action.
Passarotti
C M
CM
Formenti Group Research Laboratories. Origgio, Italy.
Valenti
M
M
Grianti
M
M
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared
D000897:Anti-Ulcer Agents; D001643:Bridged Bicyclo Compounds