RAP1: a protean regulator in yeast.
The yeast protein RAP1 is a sequence-specific DNA-binding protein that binds to many promoters, to two elements that silence mating-type genes, and to [(C)1-3A]n tracts at telomeres. RAP1 is essential for cell viability and can function as either an activator or a repressor of transcription, depending upon the context of its binding site. Recent experiments suggest that its function may be determined by different sets of protein-protein interactions at promoters and silencers. At the ends of chromosomes, RAP1 plays an important role in both silencing (telomere position effect) and telomere structure.
Shore
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Department of Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
D004247:DNA / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D016615:Telomere; D020668:rap GTP-Binding Proteins
D005656:Fungal Proteins; D004247:DNA; D019204:GTP-Binding Proteins; D020668:rap GTP-Binding Proteins