title: Design and analysis of chromosome physical mapping experiments.
abstract: Mathematical and statistical aspects of constructing ordered-clone physical maps of chromosomes are reviewed. Three broad problems are addressed: analysis of fingerprint data to identify configurations of overlapping clones, prediction of the rate of progress of a mapping strategy and optimal design of pooling schemes for screening large clone libraries.
authors: School of Mathematical Sciences, Queen Mary & Westfield College, University of London, U.K.
authors: D J
authors: DJ
authors: Balding
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D003001:Cloning, Molecular; D016172:DNA Fingerprinting; D015723:Gene Library; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D013223:Statistics as Topic