Leukotriene D4-induced signal transduction.
In a human epithelial cell line LTD4 induces a calcium signal that is dependent on both intracellular mobilization and influx of calcium. This calcium signal is generated via the activation of dual G protein pathways. Whereas the intracellular mobilization of calcium is regulated by a pertussis toxin-insensitive G protein, the subsequent influx of calcium is regulated by a pertussis toxin-sensitive G protein. Furthermore, a LTD4-induced cellular elevation of cAMP also participates in the regulation of this calcium signal. The increase in cAMP is directly related to the LTD4-induced influx of calcium, perhaps by an activation of protein kinase A and a subsequent phosphorylation of a plasma membrane channel. This model of the LTD4-induced signaling pathway in epithelial cells is outlined in Figure 2.
Sjölander
A
A
Department of Cell Biology, University of Linköping, Sweden.
Grönroos
E
E
D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism; D004847:Epithelial Cells; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D017998:Leukotriene D4 / Q000378:metabolism*; D015398:Signal Transduction
D017998:Leukotriene D4; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D002118:Calcium