title: Aspartyl alpha-((diphenylphosphinyl)oxy)methyl ketones as novel inhibitors of interleukin-1 beta converting enzyme. Utility of the diphenylphosphinic acid leaving group for the inhibition of cysteine proteases.
authors: Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania 19426.
authors: R E
authors: RE
authors: Dolle
authors: J
authors: J
authors: Singh
authors: D
authors: D
authors: Whipple
authors: I K
authors: IK
authors: Osifo
authors: G
authors: G
authors: Speier
authors: T L
authors: TL
authors: Graybill
authors: J S
authors: JS
authors: Gregory
authors: A L
authors: AL
authors: Harris
authors: C T
authors: CT
authors: Helaszek
authors: R E
authors: RE
authors: Miller
mesh_terms: D001224:Aspartic Acid / Q000737:chemistry / Q000494:pharmacology*; D002154:Calpain / Q000037:antagonists & inhibitors; D020170:Caspase 1; D002401:Cathepsin B / Q000037:antagonists & inhibitors; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D015853:Cysteine Proteinase Inhibitors; D007659:Ketones; D001224:Aspartic Acid; D002154:Calpain; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D020170:Caspase 1