Localization of the 9p melanoma susceptibility locus (MLM) to a 2-cM region between D9S736 and D9S171.
A familial melanoma susceptibility locus (MLM) was identified on the short arm of chromosome 9 in a set of Utah and Texas kindreds. Subsequent confirmation was reported for a set of 26 Australian kindreds, a set of 7 Dutch kindreds, and a set of 13 NIH melanoma kindreds. The original localization report placed the locus near the IFNA-D9S126 interval on chromosome 9p. We report further localization using D9S171 and a newly developed marker, D9S736, both of which lie in the IFNA-D9S126 interval. Analysis of this set of kindreds places the melanoma susceptibility locus in a 2-cM region that is proximal to D9S736 and distal to D9S171.
Cannon-Albright
L A
LA
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84108.
Goldgar
D E
DE
Neuhausen
S
S
Gruis
N A
NA
Anderson
D E
DE
Lewis
C M
CM
Jost
M
M
Tran
T D
TD
Nyguen
K
K
Kamb
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D005060:Europe / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008126:Lod Score; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010375:Pedigree; D013781:Texas / Q000453:epidemiology; D014589:Utah / Q000453:epidemiology