Regulation of gene expression by transcription factors Ets-1 and Ets-2.
The ETS family of transcription factors have a DNA-binding domain in common that binds a core GGA(A/T) DNA sequence. A large number of proteins have now been identified that contain an ETS DNA-binding domain (see review by Wasylyk et al., 1993). Ets-1 was first described as the cellular homolog of v-ets. which is translated as a 135-kDa gag-myb-ets fusion protein from the replication-deficient retrovirus E26 in chickens. Ets-2 was subsequently described as a closely related protein that contains the highly conserved ETS DNA-binding domain. This paper considers the manner by which the two closely related genes, Ets-1 and Ets-2, apparently play distinct roles in embryo development and in the immune system of adult mice. Although both Ets-1 and Ets-2 transform fibroblasts (Seth et al., 1989), the temporal and tissue-specific expression patterns suggest that these two proteins play distinct biological roles and consequently transactivate different downstream cellular target genes.
Tymms
M J
MJ
Molecular Embryology and Birth Defects Laboratory, Monash University, Clayton, Victoria, Australia.
Kola
I
I
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins; D005314:Embryonic and Fetal Development; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D050784:Proto-Oncogene Protein c-ets-1; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D050783:Proto-Oncogene Proteins c-ets; D012333:RNA, Messenger / Q000378:metabolism; D012097:Repressor Proteins; D017386:Sequence Homology, Amino Acid; D016385:TATA Box; D015534:Trans-Activators; D014157:Transcription Factors; D015533:Transcriptional Activation; D014982:Xenopus laevis
D004268:DNA-Binding Proteins; C107465:ERF protein, human; C494041:ETS1 protein, human; C494069:ETS2 protein, human; D050784:Proto-Oncogene Protein c-ets-1; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D012333:RNA, Messenger; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D004247:DNA