Profiles of emetic action of cisplatin in the ferret: a potential model of acute and delayed emesis.
The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was investigated in the ferret over a 72 and 40 h period respectively. Cisplatin 10 mg/kg induced retching and vomiting which rapidly declined after the first 8 h. Cisplatin 5 mg/kg induced a less intense emetic response which declined after 16 h but reappeared at approximately 32 h to reveal a 'delayed' retching and vomiting response. The use of cisplatin 5 mg/kg may offer a regimen to model cytotoxic acute and delayed emesis.
Rudd
J A
JA
School of Pharmacy, University of Bradford, UK.
Jordan
C C
CC
Naylor
R J
RJ
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005289:Ferrets; D007274:Injections, Intraperitoneal; D008297:Male; D014839:Vomiting / Q000139:chemically induced*
D002945:Cisplatin