Interaction of chlorpromazine with tricyclic anti-depressants in schizophrenic patients.
Interaction of Chlorpromazine with tricyclic antidepressants was investigated in twenty schizophrenic patients after their concurrent administration. A significant increase in serum chlorpromazine concentration was observed when administered in combination with both amitriptyline and imipramine with chlorpromazine. If combined therapy is indicated, the dose of chlorpromazine should be reduced or the time of administration of other two drugs should be adjusted to maintain therapeutic levels of chlorpromazine.
Rasheed
A
A
Faculty of Pharmacy, Punjab University, Department of Psychiatry, Mayo Hospital, Lahore.
Javed
M A
MA
Nazir
S
S
Khawaja
O
O
D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage*; D002746:Chlorpromazine / Q000008:administration & dosage* / Q000097:blood; D004347:Drug Interactions; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*
D000639:Amitriptyline; D007099:Imipramine; D002746:Chlorpromazine