title: Stability of cefodizime in solution and compatibility with other injectable drugs.
abstract: The stability of cefodizime in five intravenous infusion fluids (0.9% sodium chloride, 5% dextrose in water, 10% dextrose in water, 5% amino acid injection, 3% polygeline) was studied at room temperature and at 4 degrees C. The compatibility of cefodizime with commonly used injectable drugs (ranitidine, metoclopramide, folinic acid, furosemide, aminophilline, methylprednisolone, betamethasone, hydrocortisone, dexamethasone, ketoprofen, noramidopyrine, acetylcysteine, digoxin, diazepam, acetylsalicylic acid, chlorpromazine, clonidine, clomipramine) was studied in 0.9% sodium chloride and 5% dextrose at room temperature. At intervals during the storage periods (up to 24 hrs at room temperature; up to 6 days at 4 degrees C) color, clarity and solution pH were examined; cefodizime content was determined by a microbiological method. Cefodizime concentrations remained greater than 90% of the initial concentrations in all infusion fluids for at least 24 hrs at room temperature and 6 days at 4 degrees C. No visual changes or appreciable changes in pH were observed for any of the solutions. Immediate clouding was observed when chlorpromazine was combined with the solution of cefodizime. A color change was observed when acetylcysteine was mixed with cefodizime. An increase in pH was noted when aminophilline was added to the solution of cefodizime. However, cefodizime concentrations remained greater than 90% of the initial concentrations of the solutions after mixture with all the tested drugs for at least 24 hrs at room temperature.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Institute of Immunology and Infectious Diseases, University of Verona, Ospedale Civile Maggiore, Italy.
authors: M
authors: M
authors: Merighi
authors: A
authors: A
authors: Carlotto
authors: L
authors: L
authors: Guella
authors: S
authors: S
authors: Bonora
authors: G C
authors: GC
authors: Fibbia
authors: R
authors: R
authors: Mazzi
authors: L
authors: L
authors: Lazzarini
authors: F
authors: F
authors: Mirandola
authors: M
authors: M
authors: Cruciani
authors: E
authors: E
authors: Concia
mesh_terms: D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000737:chemistry; D004344:Drug Incompatibility; D004355:Drug Stability; D007267:Injections; D012996:Solutions; D013696:Temperature
chemical_list: D012996:Solutions; D002439:Cefotaxime; C033356:cefodizime