Central nervous system and peripheral immune functions and the sleep-wake system.
This paper reviews the relationship of aspects of the immune system to the sleep-wake system in animals and humans. In addition to the influence of certain cytokines such as interleukin-1 (IL-1) on the sleeping-waking brain, circadian measures of plasma IL-1 and peripheral immune cellular functions, for example, natural killer cell activities and cortisol are related to the sleep-wake system in humans. Changes in the circadian patterns of immune functions over the menstrual cycle are associated with the amount of progesterone and slow wave sleep. The harmonious inter-relationship of the circadian pattern of the immune, endocrine and sleep-wake systems may be important in the cause and functions of sleep.
Moldofsky
H
H
University of Toronto Centre for Sleep and Chronobiology, Ontario.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002940:Circadian Rhythm; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007111:Immunity, Cellular; D007375:Interleukin-1 / Q000097:blood; D007694:Killer Cells, Natural / Q000502:physiology; D011374:Progesterone / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
D007375:Interleukin-1; D011374:Progesterone