IFN-gamma-stimulated human vascular endothelial cells function as accessory cells for superantigen-induced TNF production in human T cells.
In the presence of IFN-gamma-stimulated vascular endothelial cells which have acquired HLA class II molecules, T cells produced tumor necrosis factors (TNF-alpha and TNF-beta) and IL-2 in response to stimulation with streptococcal pyrogenic exotoxin A.
Imanishi
K
K
Department of Microbiology and Immunology, Tokyo Women's Medical College, Japan.
Akatsuka
H
H
Inada
K
K
Uchiyama
T
T
D000938:Antigen-Presenting Cells / Q000502:physiology*; D001426:Bacterial Proteins; D016207:Cytokines / Q000096:biosynthesis*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D005098:Exotoxins / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis; D008233:Lymphotoxin-alpha / Q000096:biosynthesis; D008565:Membrane Proteins; D013297:Streptococcus pyogenes / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D001426:Bacterial Proteins; D016207:Cytokines; D005098:Exotoxins; D006684:HLA-DR Antigens; D007376:Interleukin-2; D008233:Lymphotoxin-alpha; D008565:Membrane Proteins; C117980:SpeA protein, Streptococcus pyogenes; D018089:Superantigens; D014409:Tumor Necrosis Factor-alpha; C027951:erythrogenic toxin; D007371:Interferon-gamma