Impact of cefetamet-pivoxil on intestinal microflora: in vivo study.
In our study we considered the possible interference of cefetamet-pivoxil with the intestinal microflora. We used 60 germ-free mice in which an intestinal microflora similar to the human one had been implanted. They were treated with 14.3 mg/Kg/die (standard dose) and a 28.6 mg/kg/die (daily dose) of cefetamet-pivoxil by oral route. The results obtained in vivo proved that cefetamet-pivoxil at therapeutic doses does not influence the normal intestinal microflora.
Gismondo
M R
MR
Institute of Medical Microbiology, University of Milan, Italy.
Drago
L
L
Lombardi
A
A
Fassina
C
C
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005856:Germ-Free Life; D007422:Intestines / Q000382:microbiology*; D008297:Male; D051379:Mice
D015296:Ceftizoxime; C047445:cefetamet pivoxyl