Interferon-alpha facilitates renal transplantation in hemodialysis patients with chronic viral hepatitis.
Interferon-alpha has not been used previously in hemodialysis patients with chronic hepatitis B and C. This uncontrolled report evaluates the biochemical and/or histologic profile resulting from the administration of interferon-alpha in seven hemodialysis patients, two with chronic hepatitis B and five with hepatitis C. Biochemical improvement was noted in all patients. Histologic progression did not occur in the two cases in which such assessment was made, and five of them were subsequently transplanted without recurrence of disease.
Duarte
R
R
Department of Medicine, King Fahad National Guard Hospital, Riyadh, Saudi Arabia.
Huraib
S
S
Said
R
R
Abdel-Khadir
A
A
Sullivan
S
S
Chaballout
A
A
Sbeih
F
F
Mughal
T
T
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy; D006526:Hepatitis C / Q000188:drug therapy; D006525:Hepatitis, Viral, Human / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D006435:Renal Dialysis
D016898:Interferon-alpha