[Postradiation structural changes in the thymocyte and lymphocyte plasma membranes in the fractional irradiation of rats].
On days 1 and 4 after fractionated irradiation of rats with dose of 0.75 Gy changes in thymocyte and lymphocyte plasma membrane structures were studied. Structural parameters of fluorescence probe auramin binding, viscosity of free lipids and lipids bound with integral proteins as well as structural changes of membrane protein structure were determined. It was shown that after exposure to low doses the changes in membrane protein structures occurred both in thymocytes and lymphocytes. The changes in viscosity of membrane lipids and patterns of auramin binding were more pronounced in lymphocytes than in thymocytes. It is suggested that radiosensitivity of lymphocytes is higher than that of thymocytes.
Gubskiĭ
V I
VI
Dreval'
V I
VI
Mitriaeva
N A
NA
Ishkhanova
M A
MA
Ianovskaia
L G
LG
D000818:Animals; D001576:Benzophenoneidum; D002462:Cell Membrane / Q000378:metabolism / Q000528:radiation effects / Q000648:ultrastructure; D004307:Dose-Response Relationship, Radiation; D005456:Fluorescent Dyes; D008214:Lymphocytes / Q000378:metabolism / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male; D008563:Membrane Lipids / Q000528:radiation effects; D008565:Membrane Proteins / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects* / Q000648:ultrastructure; D013997:Time Factors; D014783:Viscosity / Q000528:radiation effects
D005456:Fluorescent Dyes; D008563:Membrane Lipids; D008565:Membrane Proteins; D001576:Benzophenoneidum
Postradiatsionnye izmeneniia struktury plazmaticheskikh membran timotsitov i limfotsitov pri fraktsionirovanii obluchenii krys.