title: Compositional properties of nuclear genes from Plasmodium falciparum.
abstract: We have analyzed the compositional distributions of coding sequences and their different codon positions, as well as the codon usage of the nuclear genes of Plasmodium falciparum, a parasite characterized by an extremely GC-poor genome. As expected, coding sequences are AT-rich, codon usage is strongly biased towards A or T in third codon positions, and some particular amino acids (aa) are especially abundant in the encoded proteins. Remarkably, however, no difference was detected between housekeeping (HK) and antigen (Ag) genes, in spite of differences in expression level and evolutionary constraints. Moreover, all the features found in P. falciparum are very similar to those found in a bacterium characterized by a very GC-poor genome, Staphylococcus aureus. These findings stress the importance of compositional constraints in determining codon usage and aa utilisation.
authors: Laboratoire de Génétique Moléculaire, Institut Jacques Monod, Paris, France.
authors: H
authors: H
authors: Musto
authors: H
authors: H
authors: Rodriguez-Maseda
authors: G
authors: G
authors: Bernardi
mesh_terms: D000596:Amino Acids / Q000235:genetics; D000818:Animals; D001482:Base Composition; D002467:Cell Nucleus / Q000235:genetics*; D003062:Codon / Q000235:genetics; D017125:Genes, Protozoan / Q000235:genetics*; D005815:Genetic Code / Q000235:genetics*; D010963:Plasmodium falciparum / Q000235:genetics*; D013211:Staphylococcus aureus / Q000235:genetics
chemical_list: D000596:Amino Acids; D003062:Codon