title: Langerhans cells closely associated with Thy-1-positive dendritic cells in the stratified squamous mucosal epithelium of mice.
abstract: An immunohistochemical study was carried out on two types of dendritic immune cells, Langerhans cells and Thy-1-positive cells, in the epithelium of the forestomach of 1-, 2-, 3-, 4- and 8-week-old mice. Investigation focused on how both types of cells were distributed and might interact in the mucosal epithelium. Langerhans cells and Thy-1-positive dendritic cells appeared in mucosal epithelium at 3 weeks of age, while in the epidermis they were first observed just after birth. In contrast with the epidermal Thy-1-positive cells, mucosal Thy-1-positive cells were closely associated with Langerhans cells. Electron microscopy also confirmed that two types of immune cells interact directly in the stratified squamous mucosal epithelium of mice.
authors: Department of Anatomy, Nagoya University School of Medicine, Japan.
authors: J
authors: J
authors: Niwa
authors: M
authors: M
authors: Kobayashi
authors: Y
authors: Y
authors: Koyama
authors: H
authors: H
authors: Kotani
authors: K
authors: K
authors: Mitsudo
authors: T
authors: T
authors: Hoshino
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D003713:Dendritic Cells / Q000737:chemistry* / Q000166:cytology* / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology* / Q000254:growth & development / Q000648:ultrastructure; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D018800:Thy-1 Antigens / Q000032:analysis*
chemical_list: D018800:Thy-1 Antigens