A rabbit ear model for cold stress testing.
A rabbit ear model resembling the human digit was studied to determine the vascular response of the rabbit ear to a cold stress. Following moderate cooling (10 minutes at 5 degrees - 8 degrees C), auricular blood flow and cutaneous perfusion were reduced. This decrease was reversed by 30 minutes of warming. The response in the rabbit ear to cold stress is similar to that of normal human digits. The similarities between the control of the circulation in human digits and rabbit ears may result from the similarities in digital and auricular vascular receptors and receptor subtypes. Verification of the rabbit model provides an experimental method for obtaining important data regarding digital pathophysiology and the treatment of cold intolerance. Further study with this model will provide clinically relevant information regarding the pathophysiology of digital thermoregulatory abnormalities.
Smith
T L
TL
Department of Orthopaedic Surgery, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC.
Gordon
S
S
Holden
M B
MB
Smith
B P
BP
Russell
G B
GB
Koman
L A
LA
D000818:Animals; D001833:Body Temperature Regulation; D003080:Cold Temperature; D004423:Ear / Q000098:blood supply*; D005385:Fingers / Q000098:blood supply / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation / Q000502:physiology; D008955:Models, Cardiovascular; D011817:Rabbits; D013312:Stress, Physiological / Q000503:physiopathology*