Hypoglycemic effects of leucodelphinidin derivative isolated from Ficus bengalensis (Linn).
A Leucodelphinidin derivative isolated from the bark of Ficus bengalensis Linn demonstrated hypoglycemic action at a dosage of 250 mg/kg given both in normal and alloxan diabetic rats. It's action is closely similar to that of an effective dose of glibenclamide (2 mg/kg) tested under the same conditions. However, after a glucose load the plant product is only just significantly active but not as effective as the sulphonylurea. The efficacy of the plant product as a hydroglycemic agent adds to its other therapeutic effects, as it belongs to the class of flavonoids.
Geetha
B S
BS
Department of Biochemistry, University of Kerala, Trivandrum.
Mathew
B C
BC
Augusti
K T
KT
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology* / Q000627:therapeutic use; D007003:Hypoglycemia / Q000139:chemically induced*; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D001786:Blood Glucose; D005419:Flavonoids; D010936:Plant Extracts; C031451:leukoefdin; D005905:Glyburide