Necrotizing retinitis in severe combined immunodeficiency mice following intracameral inoculation of herpes simplex virus type 1.
Necrotizing retinitis in severe combined immunodeficiency (SCID) mice following intracameral inoculation of herpes simplex virus type 1 provided an experimental model for acute retinal necrosis in AIDS and other immunocompromised patients. In order to assess the involvement of the immunological response in the pathogenesis, adoptive transfer experiments were conducted. Without transfer, SCID mice developed predominantly unilateral necrotizing retinitis and died within 10 days. Transfer of immune serum lengthened the survival time but resulted in bilateral necrotizing retinitis. Two of 5 mice transferred with CD4+ T cells and none of 7 transferred with CD8+ T cells developed bilateral necrotizing retinitis. Our results indicate that ipsilateral retinal necrosis occurs with or without a specific immunological response, and that antibodies and/or CD4+ T cells accelerate the contralateral retinal necrosis.
Minagawa
H
H
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Liu
Y
Y
Ishibashi
T
T
Inomata
H
H
Mori
R
R
D000818:Animals; D000867:Anterior Chamber / Q000821:virology; D000914:Antibodies, Viral / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002522:Chlorocebus aethiops; D015828:Eye Infections, Viral / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D016219:Immunotherapy, Adoptive; D051379:Mice; D008807:Mice, Inbred BALB C; D015882:Retinal Necrosis Syndrome, Acute / Q000276:immunology* / Q000821:virology; D016511:Severe Combined Immunodeficiency / Q000276:immunology*; D014709:Vero Cells
D000914:Antibodies, Viral