Neurocristopathy in mother (ganglioneuroblastoma) and daughter (aganglionosis): incidental or causal?
We report on a mother who had been treated for a ganglioneuroblastoma and her daughter who had a long segment aganglionosis. Review of the relevant literature and recent molecular findings warrant the conclusion that most likely, there is a causal relation between these two neurocristopathies.
Hamel
C J
CJ
Department of Human Genetics, Center S.E. Netherlands, University Hospital Nijmegen.
Severijnen
R S
RS
De Vaan
G A
GA
D000328:Adult; D002675:Child, Preschool; D005260:Female; D018305:Ganglioneuroblastoma / Q000175:diagnosis / Q000235:genetics*; D006627:Hirschsprung Disease / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010641:Phenotype; D011247:Pregnancy; D013577:Syndrome; D013899:Thoracic Neoplasms / Q000175:diagnosis / Q000235:genetics*