title: Adhesion molecules: a new target for immunoliposome-mediated drug delivery.
abstract: The anti-ICAM-1 monoclonal antibody F10.2 was conjugated to liposomes to target to cells expressing the cell adhesion molecule ICAM-1. We demonstrate that F10.2 immunoliposomes bind to human bronchial epithelial cells (BEAS-2B) and human umbilical vein endothelial cells (HUVEC) in a specific, dose- and time-dependent manner. It appears that the degree of ICAM-1 expression is the limiting factor in the degree of immunoliposome binding to the cells. These results are a first step in the strategy for specific drug delivery to target sites characterised by increased expression of adhesion molecules.
authors: Department of Pharmacology, Utrecht University, The Netherlands.
authors: P G
authors: PG
authors: Bloemen
authors: P A
authors: PA
authors: Henricks
authors: L
authors: L
authors: van Bloois
authors: M C
authors: MC
authors: van den Tweel
authors: A C
authors: AC
authors: Bloem
authors: F P
authors: FP
authors: Nijkamp
authors: D J
authors: DJ
authors: Crommelin
authors: G
authors: G
authors: Storm
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D001980:Bronchi / Q000166:cytology / Q000276:immunology; D002460:Cell Line; D016503:Drug Delivery Systems; D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D008081:Liposomes; D014471:Umbilical Veins
chemical_list: D000911:Antibodies, Monoclonal; D008081:Liposomes; D018799:Intercellular Adhesion Molecule-1