[Comparative secretory profiles of benign and malignant pheochromocytomas].
Distant metastases are the only clue for diagnosis of malignancy in pheochromocytoma patients. This study was designed to define a secretory profile possibly suggestive of malignancy. Among 79 pheochromocytomas (55 benign, 24 malignant), dopamine-secretion, either exclusive or blended with other catecholamines was found in 34.5% of benign and in 75% of malignant tumors. Dopamine secretion, although if more frequent and more abundant in cases of malignant pheochromocytomas, is therefore not actually diagnostic, but only suggestive of malignancy. It demands life-long follow-up as metachronous metastases may supervene extremely late in the course of the disease.
Proye
C
C
Service de Chirurgie Générale et Endocrinienne, CHU de Lille, Hôpital, Huriez.
Racadot-Leroy
N
N
Vix
M
M
Vermesse
B
B
Carnaille
B
B
D000310:Adrenal Gland Neoplasms / Q000652:urine*; D004298:Dopamine / Q000031:analogs & derivatives / Q000652:urine*; D004837:Epinephrine / Q000652:urine*; D006801:Humans; D009638:Norepinephrine / Q000652:urine*; D010673:Pheochromocytoma / Q000652:urine*
C001746:3-methoxytyramine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Profils sécrétoires comparatifs des phéochromocytomes bénins et des phéochromocytomes malins.