title: The effect of clonidine on intra-operative requirements of fentanyl during combined epidural/general anaesthesia.
abstract: The study evaluates the analgesic effects of epidural clonidine in patients undergoing abdominal hysterectomy under combined epidural/general anaesthesia. Forty ASA 1-2 patients were divided into two groups who received epidurally either clonidine 300 micrograms (group 1) or placebo (group 2). Anaesthesia was maintained with oxygen/nitrous oxide, a midazolam infusion, vecuronium, and boluses of fentanyl 100 micrograms administered as needed to maintain cardiovascular stability. The mean (SD) intraoperative fentanyl requirements were 2.05 (0.18) and 3.66 (0.3) micrograms.kg-1.h-1 for groups 1 and 2 respectively (p < 0.001). Patients in Group 1 had a lower heart rate after tracheal intubation and surgical incision (p < 0.02). In the recovery room, pain intensity was lower in group 1 (p < 0.003) and the mean (SD) time until analgesia request was increased from 48.5 (8.4) min in group 2 to 235.7 (33.2) min in group 1 (p < 0.001). Our results demonstrate that epidural clonidine produces decreased fentanyl requirements, improved cardiovascular stability, reduced pain intensity and effective postoperative analgesia in the recovery room.
authors: Anaesthesiology Service, Hospital de Figueres, Spain.
authors: G
authors: G
authors: Murga
authors: E
authors: E
authors: Samsó
authors: J
authors: J
authors: Valles
authors: P
authors: P
authors: Casanovas
authors: M M
authors: MM
authors: Puig
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural; D000762:Anesthesia Recovery Period; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D003000:Clonidine; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007044:Hysterectomy; D010149:Postoperative Pain / Q000517:prevention & control
chemical_list: D003000:Clonidine; D005283:Fentanyl