[Antimycobacterial acting carbazole derivatives].
Carbazoles are synthesized and tested for antimycobacterial properties (M. tuberculosis H 37 Ra, Middlebrook-7H9-broth). The different antimycobacterial properties of diastereomeres are examined using compounds 32 and 33, those of a racemic compound and the (+)-enantiomer are tested with (+/-)-12/(+)-12 and (+/-)-5/(+)-5, respectively. (+)-12 is prepared by enantioselective synthesis.
Mahboobi
S
S
Institut für Pharmazie, Universität Regensburg.
Kuhr
S
S
Meindl
W
W
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009161:Mycobacterium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects
D000995:Antitubercular Agents; D002227:Carbazoles
Antimycobakteriell wirksame Carbazolderivate.