Genome analysis of South American adenovirus strains of serotype 7 collected over a 7-year period.
DNA restriction analysis was carried out on a sample of 212 epidemiologically unrelated adenovirus (Ad) strains of serotype 7 isolated in Chile, Uruguay, and Argentina from nasopharyngeal aspirates of children with acute lower respiratory disease between 1984 and 1990. The identified genome types were Ad7b (n = 12), Ad7c (n = 21), and Ad7h (n = 179). The analysis of the occurrence of the three genome types throughout the study period revealed that Ad7c was the predominant virulent variant in 1984 and indicated that a shift to genome type 7h took place in 1986. Ad7b cocirculated with the other genomic variants at a relatively low frequence.
Kajon
A
A
Department of Virology, University of Umeå, Sweden.
Wadell
G
G
D000257:Adenoviridae Infections / Q000453:epidemiology / Q000382:microbiology*; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D002648:Child; D016679:Genome, Viral; D006801:Humans; D009305:Nasopharynx / Q000382:microbiology; D012150:Polymorphism, Restriction Fragment Length; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology*; D012189:Retrospective Studies; D013020:South America / Q000453:epidemiology; D014774:Virulence / Q000235:genetics