[Early treatment of attacks of pernicious malaria with artemisinine per os].
416 cases of P. falciparum cerebral malaria are treated with various anti-M drugs: mortality rate is 25% with quinacrine, 12.3%; quinine alone, and 10.1% with quinine associated to sulfonamide. During 1991-1992, artemisinin per os is used in the early treatment of 21 cases of cerebral malaria, in according to propose a regimen practicable at primary health care units, where parenteral injection is sometimes unavailable: coma clearance after 14-21 hours in 100%, fever clearance after 54-97 hours in 100%, and parasite clearance in 100% after 101 hours; no case of death is found.
Bùi
D
D
Hôpital général, Hanoï, Viet-nam.
Dình
V B
VB
D037621:Artemisinins; D006801:Humans; D007700:Kinetics; D016779:Malaria, Cerebral / Q000188:drug therapy* / Q000401:mortality; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000627:therapeutic use*
D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin
Traitement précoce de l'accès pernicieux palustre par l'artémisinine per os.