Effects of oxatomide and KW-4679 on acetylcholine-induced responses in the isolated acini of guinea pig nasal glands.
The antiallergic drugs oxatomide and KW-4679 were assessed to show inhibitory effects on ionic currents and intracellular Ca2+ concentration ([Ca2+]i) increase induced by acetylcholine (ACh) in isolated acini of the guinea pig nasal gland. Both K+ and Cl- currents evoked by ACh were inhibited by addition of oxatomide and KW-4679 at the concentration of 10(-5) M. KW-4679 (10(-5) M) inhibited the increase in [Ca2+]i induced by ACh, whereas no effect of oxatomide (10(-5) M) on Ca2+ responses was observed. These findings suggest that both drugs suppress electrolyte and fluid secretion in the nasal glands by different mechanisms.
Ikeda
K
K
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Wu
D
D
Takasaka
T
T
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D018118:Chloride Channels / Q000187:drug effects; D003990:Dibenzoxepins / Q000494:pharmacology*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism; D000069605:Olopatadine Hydrochloride; D010879:Piperazines / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects
D018118:Chloride Channels; D003990:Dibenzoxepins; D006634:Histamine H1 Antagonists; D010879:Piperazines; D015221:Potassium Channels; D000069605:Olopatadine Hydrochloride; C015408:oxatomide; D000109:Acetylcholine; D002118:Calcium