title: Reciprocal modulation of corticotropin-releasing factor and interleukin-1 receptors following ether-laparotomy stress in the mouse.
abstract: Ether-laparotomy stress resulted in a dramatic decrease in specific iodine-125-labeled ovine CRF binding ([125I]oCRF) in the pituitary at 6 h after the onset of the stress although it did not affect [125I]oCRF binding in the pituitary at 2 h after the stress. [125I]oCRF binding was unchanged in the frontal cortex after the stress. In contrast, [125I]interleukin-1 (IL-1)alpha binding was significantly increased in the pituitary at 2 h after the stress and tended to be higher than non-stressed levels at 6 h after the stress but was not statistically significant. Ether-laparotomy stress did not affect [125I]IL-1 alpha binding in hippocampus, spleen and testis at any time after the stress. Plasma adrenocorticotropic hormone (ACTH) and corticosterone were increased at 2 h after the stress. These data demonstrate complex interactions between CRF and IL-1 receptors on HPA axis during stress.
authors: Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan.
authors: T
authors: T
authors: Takao
authors: C
authors: C
authors: Tojo
authors: T
authors: T
authors: Nishioka
authors: H
authors: H
authors: Kurokawa
authors: T
authors: T
authors: Takemura
authors: K
authors: K
authors: Hashimoto
authors: E B
authors: EB
authors: De Souza
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000758:Anesthesia; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004986:Ether; D007375:Interleukin-1 / Q000378:metabolism; D007813:Laparotomy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010902:Pituitary Gland / Q000378:metabolism; D018019:Receptors, Corticotropin-Releasing Hormone / Q000378:metabolism*; D017472:Receptors, Interleukin-1 / Q000378:metabolism*; D012756:Sheep; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D018019:Receptors, Corticotropin-Releasing Hormone; D017472:Receptors, Interleukin-1; D004986:Ether; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone