Hepatitis virus-related hepatocarcinogenesis.
We propose that hepatitis virus can cause an increase in the incidence of liver cancer by a combination of two mechanisms: (1) cell killing and stimulation of mitosis leading to an accumulation of events necessary for transformation, and (2) an increase in chromosomal instability mediated by induced recombinogenic protein(s) during chronic hepatitis.
Hino
O
O
Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
Kajino
K
K
D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics; D006509:Hepatitis B / Q000150:complications*; D006515:Hepatitis B virus / Q000235:genetics; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*