title: [Total/near-total glossectomy for advanced carcinoma of the tongue].
abstract: Poor survival rates and the limited palliation afforded by radiotherapy alone, together with progress made in reconstructive surgery in restoring mucosal continuity after large resections, make total glossectomy reasonably indicated for treatment of advanced carcinoma of the tongue. The Authors reviewed 19 cases (17 males, 2 females, mean age 58.4 years) of total and near total glossectomy without laryngectomy treated at National Cancer Institute "Regina Elena" of Rome from 1990 to 1993 in order to evaluate oncological and functional results. All patients were reconstructed immediately, 16 with a pectoralis major flap, 2 with a nasolabial flap and 1 with a radial forearm free flap and were available for follow-up from 6 to 45 months (mean 29 months). There was no operative mortality and no patient needed total laryngectomy for aspiration. The rate of local recurrencies was 52.6%, most of them (75%) in patients who had undergone total/near total glossectomy for recurrence. Survival rate was 61.5% after 1 year and 20% after 2 years. 94% of patients resumed swallowing and independent oral alimentation (48% of them without any dysphagia); 84%; of the patients were decannulated and 48% produced easily intellegible speech. Data from our experience let us conclude that, in the light of the acceptable functional results obtained with reconstructive flaps, total glossectomy should be considered as the primary treatment modality in advanced carcinoma of the tongue (including T2 > 3 cm exceeding midline), and should not be reserved only for salvaging hopeless situations.
authors: Divisione di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Isituto per la studio e la cura dei Tumori Regina Elena, Roma.
authors: M G
authors: MG
authors: Vigili
authors: F
authors: F
authors: Marzetti
authors: M
authors: M
authors: Ducci
authors: O
authors: O
authors: Palma
authors: S
authors: S
authors: Pompei
authors: A
authors: A
authors: Marzetti
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D003680:Deglutition Disorders / Q000209:etiology; D005260:Female; D005927:Glossectomy / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010369:Pectoralis Muscles / Q000601:surgery; D013064:Speech Disorders / Q000209:etiology; D013518:Surgery, Plastic; D013524:Surgical Flaps; D014059:Tongue / Q000473:pathology / Q000601:surgery*; D014062:Tongue Neoplasms / Q000473:pathology / Q000601:surgery*
vernacular_title: La glossectoma totale/subtotale nel trattamento dei tumori avanzati della lingua.