1994 William J. Stickel Bronze Award. Amino acids, dipeptides, and leg skeletal muscle wound healing in diabetes.
The authors determined the effects of active amino acids and dipeptides as anabolic agents on surgically induced wound healing in lower extremity skeletal muscles in diabetic and normal rats. In order to induce diabetes, adult male Sprague-Dawley rats (200 g; 10 to 12 animals per group) were injected with streptozotocin (65 mg/kg) 30 days before the onset of the experiment. Their blood sugars were checked at this time. Each group of rats was injected with either one stimulatory amino acid or dipeptide (150 mg/kg body weight) subcutaneously in saline for 7 days and their anabolic effects (RNA, DNA, protein, and collagen contents) on lower extremity skeletal muscle wound healing determined in both diabetic and normal control groups. It is hoped that a treatment regimen will be developed using synergistic anabolic agents locally to decrease the lower extremity muscle healing time. This will enable the diabetic patient to become mobile sooner after surgery.
Pitkow
H S
HS
Pennsylvania College of Podiatric Medicine, Philadelphia 19107.
Brekke
M
M
Harte
G
G
Labbad
Z G
ZG
Bitar
M S
MS
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004151:Dipeptides / Q000494:pharmacology*; D006614:Hindlimb / Q000293:injuries; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects*
D000596:Amino Acids; D004151:Dipeptides