HLA typing in hairy cell leukemia.
In HCL patients some cases of familial occurrence of the disease were reported, without an association with a specific haplotype or HLA antigen. In a series of a non familial HCL patients an increase in DR11 frequency was reported. We performed HLA class I and class II antigens in a series of 38 consecutive HCL patients. An increased frequency of B17 (10/38-27%) and DR11 (22/38-57%) antigens compared with the normal Caucasian population was recorded. As clinical characteristics, no significant differences were recognized between DR11 positive and DR11 negative patients. In response to IFN treatment, a complete response (CR) was achieved in 20% of DR11 patients and in 46% of DR11 negative patients. In this study an increase frequency of B17 and DR11 antigens was found; furthermore DR11 positive patients seem to be less responsive to IFN treatment but a larger series of patients will have to be studied in the future in order to establish this observation with more certainty.
Annino
L
L
Hematology, Dept. of Human Biopathology, University La Sapienza, Rome, Italy.
Ferrari
A
A
Laurenti
L
L
Perrone
M P
MP
Romani
C
C
Pacchiarotti
A
A
Girelli
G
G
Mandelli
F
F
D000328:Adult; D000368:Aged; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015235:HLA-B Antigens / Q000032:analysis / Q000235:genetics; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D006650:Histocompatibility Testing; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D015235:HLA-B Antigens; C037449:HLA-B17 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C080766:HLA-DR11 antigen