Synthesis and antitumor activity evaluation of 1-[(arylidene)amino]adamantanes.
Several 1-[(arylidene)amino]adamantanes were synthesized and evaluated in vitro as antitumor agents against 60 human tumor cell lines. Some of these derivatives showed specificity for human leukemia cell lines and 1-[(2-bromobenzylidene)amino]adamantane (2) (NSC 631076-L), the most active compound, was selected by the Biological Evaluation Committee (BEC), for in vivo testing.
Chimirri
A
A
Dipartimento Farmaco-Chimico, Università di Messina, Italy.
Gitto
R
R
Grasso
S
S
Monforte
A M
AM
Zappalà
M
M
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D000218:Adamantane