title: Pharmacological effects of Azadirachta indica (neem) leaf extract on the ECG and blood pressure of rat.
abstract: Neem leaf alcoholic extract (NLE) was investigated for its effects on the ECG and blood pressure of rat. Intravenous administration of NLE (100, 300 and 1000 mg/kg) resulted in initial bradycardia followed by cardiac arrhythmia in rats. NLE produced a significant and dose-related fall in blood pressure which was immediate, sharp and persistent. Pre-treatment with either atropine or mepyramine failed to prevent the hypotensive effect of NLE.
authors: Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly.
authors: K M
authors: KM
authors: Koley
authors: J
authors: J
authors: Lal
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D001919:Bradycardia / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects*; D000431:Ethanol / Q000737:chemistry; D006339:Heart Rate / Q000187:drug effects*; D007022:Hypotension / Q000139:chemically induced; D007275:Injections, Intravenous; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats
chemical_list: D010936:Plant Extracts; D000431:Ethanol