Structure-activity relationships and interactions among trichothecene mycotoxins as assessed by yeast bioassay.
A yeast (Kluyveromyces marxianus) bioassay was used to establish the relative toxicity of 16 trichothecenes and some of their interactions. Removal of an isovaleryl group, one or two acetyl groups, or two acetyl plus an isovaleryl groups from T-2 toxin (T2) to form diacetoxyscirpenol, HT-2 toxin (HT2), T2-triol and T-2 tetraol (T2-4ol) decreased toxicity 7, 36, 276 and 558-fold, respectively. A combination of T2 and HT2, T2 and T2-4ol, deoxynivalenol (DON) and nivalenol (NIV), or DON and T2 exhibited synergistic (T2 and HT2 or DON and NIV) or antagonistic (DON and T2) responses.
Madhyastha
M S
MS
Department of Animal Science, University of Manitoba, Winnipeg, Canada.
Marquardt
R R
RR
Abramson
D
D
D001681:Biological Assay; D004347:Drug Interactions; D006863:Hydrogen-Ion Concentration; D007716:Kluyveromyces / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013605:T-2 Toxin / Q000633:toxicity; D014255:Trichothecenes / Q000737:chemistry / Q000633:toxicity*
D014255:Trichothecenes; D013605:T-2 Toxin