title: Heart transplantation in patients with Marfan's syndrome: a survey of attitudes and results.
abstract: Our institution performed an orthotopic heart transplantation in a patient with Marfan's syndrome. The immediate postoperative course was complicated with ultimate discharge; however, this patient died within 1 year as a result of an aortic dissection. On the basis of our experience, we surveyed all heart transplant centers listed with the North American Transplant Coordinator Organization for other patients with Marfan's syndrome who had been referred for transplantation. Nearly one third of responding centers evaluated a total of 30 patients with Marfan's syndrome. Of these, only 13 were formally listed for a donor organ and 11 underwent heart transplantation with an operative mortality of 9.1% (n = 1). Posttransplantation morbidity was significant and includes a 40% (n = 4) incidence of thoracic aorta dissection (one fatal) in operative survivors. There were three other non-dissection-related late deaths for an overall survival of 54.4% after a mean follow-up of 33.0 months. In this shared experience, it appears that the known vascular complications of Marfan's syndrome may diminish the anticipated results after heart transplantation. The reluctance to place these patients on heart transplant donor waiting lists can be justified.
authors: Indiana University School of Medicine, Department of Surgery, Indianapolis 46202.
authors: K A
authors: KA
authors: Kesler
authors: J J
authors: JJ
authors: Hanosh
authors: J
authors: J
authors: O'Donnell
authors: S
authors: S
authors: Faust
authors: M W
authors: MW
authors: Turrentine
authors: Y
authors: Y
authors: Mahomed
authors: J W
authors: JW
authors: Brown
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000209:etiology; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology; D001291:Attitude of Health Personnel; D001807:Blood Vessel Prosthesis; D002423:Cause of Death; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000009:adverse effects; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D015994:Incidence; D008297:Male; D008382:Marfan Syndrome / Q000150:complications / Q000601:surgery*; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D012017:Referral and Consultation; D015996:Survival Rate; D014019:Tissue Donors; D014850:Waiting Lists
chemical_list: D011093:Polyethylene Terephthalates