title: Cytogenetic data in 41 patients with multiple myeloma. Karyotype and other clinical parameters.
abstract: Cytogenetic data of 41 patients diagnosed with multiple myeloma (MM) are reported. In all samples, cytogenetic studies were made of short-term and B-cell-stimulated culture: 20 cases (48.8%) showed chromosome abnormalities; 14 karyotypes were hypo- or pseudodiploid, and six were hyperdiploid. The most frequent numerical changes affected chromosomes 7, 11, 5 (gains), 14, 20, and Y (losses). Chromosome structural rearrangements of 22q were noted in six patients. Other and recurrent cytogenetic abnormalities were changes involving chromosomes 1, 14, and 17. A significant relation was observed between presence of chromosome abnormalities and the following hematologic parameters: clinical stage III (p = 0.0212), bone marrow (BM) plasma cell infiltration greater than 30% (p = 0.0379), presence of bone lesions (p = 0.0051), and beta 2-microglobulin levels greater than 4,000 md/dl (p = 0.0194).
authors: Department of Genetics, University of Navarra, Pamplona, Spain.
authors: J C
authors: JC
authors: Cigudosa
authors: M J
authors: MJ
authors: Calasanz
authors: M D
authors: MD
authors: Odero
authors: F
authors: F
authors: Prosper
authors: A
authors: A
authors: Etxaniz
authors: J
authors: J
authors: Marin
authors: J
authors: J
authors: Rifón
authors: A
authors: A
authors: Gullón
authors: E
authors: E
authors: Rocha
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000737:chemistry; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*