[The effect of cadmium on the structure of the circadian cycle of waking-sleep and on the EEG in Wistar rats].
The effect of cadmium on spectral EEG parameters of the hippocampus, somatosensory, visual and auditory cortical zones, as well as representation of wakefulness, slow-wave sleep and paradoxical sleep has been studied in the diurnal cycle of Wistar rats. It was shown that single injections of cadmium chloride (3 mg/kg, intraperitoneally) induce significant changes in the structure of wakefulness-sleep cycle, whereas no reliable qualitative changes in EEG parameters were observed. After long-term (9 days) administration of cadmium chloride (1.5 mg/kg, intraperitoneally), epileptiform activity was noticed in the EEG pattern, whereas predisposition of animals to audiogenic seizures increased.
Vataev
S I
SI
Mal'gina
N A
NA
Oganesian
G A
GA
D000208:Acute Disease; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D019256:Cadmium Chloride; D002105:Cadmium Poisoning / Q000503:physiopathology; D002712:Chlorides / Q000494:pharmacology*; D002908:Chronic Disease; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects* / Q000295:instrumentation / Q000379:methods; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D002712:Chlorides; D002104:Cadmium; D019256:Cadmium Chloride
Vliianie kadmiia na strukturu sutochnogo tsikla bodrstvovanie--son i EEG u krys linii Vistar.