Interleukin-6 and coagulation-fibrinolysis fluctuations after laparoscopic and conventional cholecystectomy.
This study assesses quantitatively the fluctuations of interleukin-6 (IL-6) and coagulation-fibrinolysis proteins in patients undergoing elective laparoscopic (n = 14) and conventional (n = 10) cholecystectomy. The patients in both groups were comparable in age and sex. Serum levels of interleukin-6, and plasma levels of fibrinogen, von Willebrand factor-antigen, tissue-type plasminogen activator-antigen, and plasminogen activator inhibitor-1 were determined for up to 48 h postoperatively. The postoperative changes of all parameters tested were comparable in both patient groups with a trend toward a higher interleukin-6 response at 8 h postincision (NS) and a trend toward a higher fibrinolysis inhibition (NS) after conventional cholecystectomy.
Vander Velpen
G
G
Department of Abdominal Surgery, U.Z. Gasthuisberg, University of Leuven, Belgium.
Penninckx
F
F
Kerremans
R
R
Van Damme
J
J
Arnout
J
J
D001779:Blood Coagulation Factors / Q000032:analysis*; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011184:Postoperative Period; D011446:Prospective Studies; D013312:Stress, Physiological / Q000097:blood; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000097:blood*
D001779:Blood Coagulation Factors; D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator