title: Seromuscular colocystoplasty lined with urothelium: experience with 16 patients.
abstract: OBJECTIVE
  Report of initial clinical experience with seromuscular colocystoplasty lined with urothelium (SCLU), a new operation to increase bladder capacity and compliance without incorporating intestinal mucosa into the urinary tract. We have previously reported the technique and results of this procedure in a canine model.
  
  
  METHODS
  Sixteen patients underwent SCLU at two institutions. Their charts were reviewed retrospectively. The patients have been observed for a mean of 12 months.
  
  
  RESULTS
  Postoperatively, the bladder capacity increased an average of 2.4-fold from a mean of 139 mL (+/- 23.7 SEM) to 335 mL (+/- 38.9 SEM) in 14 patients (P < 0.001). Two patients required reaugmentation. Preoperative and postoperative bladder end filling pressures were available in 13 patients and decreased from a mean of 51.6 cm H2O (+/- 4.2 SEM) to 27.7 cm H2O (+/- 2.4 SEM) (P < 0.001). Of the 16 patients, 13 were incontinent preoperatively; 5 had renal insufficiency. Three patients have undergone renal transplantation following SCLU. After SCLU, 13 patients were dry day and night, 1 incontinent at night only, and 2 remained incontinent. Ten patients have undergone postoperative bladder biopsy. Seven demonstrate urothelium covering the augmented portion of the bladder, 2 have regrowth of colonic mucosa, and 1 shows a mixture of colonic mucosa and urothelium.
  
  
  CONCLUSIONS
  The results presented suggest that SCLU is a viable alternative to the more conventional forms of bladder augmentation in selected patients.
authors: Department of Pediatric Urology, Children's Hospital of Michigan, Wayne State University, Detroit.
authors: R
authors: R
authors: Gonzalez
authors: H
authors: H
authors: Buson
authors: C
authors: C
authors: Reid
authors: Y
authors: Y
authors: Reinberg
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000637:transplantation*; D003404:Creatinine / Q000097:blood; D004848:Epithelium / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009130:Muscle, Smooth / Q000601:surgery*; D012086:Reoperation; D001743:Urinary Bladder / Q000473:pathology / Q000601:surgery*; D001745:Urinary Bladder Diseases / Q000150:complications / Q000601:surgery*; D001750:Urinary Bladder, Neurogenic / Q000601:surgery; D014549:Urinary Incontinence / Q000209:etiology / Q000601:surgery
chemical_list: D003404:Creatinine