Effects of chloroquine on pentylenetetrazol-induced convulsions in mice.
The effects of chloroquine pretreatment were investigated on pentylenetetrazol-induced clonic-tonic convulsions in mice. The results demonstrated that lower doses of chloroquine (1.0-5.0 mg kg-1) significantly induced a delay in onset time to the clonic component of convulsions and reduced the incidence of the tonic phase of convulsions and mortality. In contrast, at a higher dose range (10.0-50.0 mg kg-1) chloroquine had opposite effects. This study points out the biphasic action of chloroquine on clonic-tonic PTZ convulsions and its preferential effect against the tonic phase of convulsions.
N'Gouemo
P
P
Laboratory of Experimental Medicine, INSERM U249 CNRS, Montpellier, France.
Ben Attia
M
M
Belaidi
M
M
D000818:Animals; D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control*
D002738:Chloroquine; D010433:Pentylenetetrazole