title: Survival after surgery for cancer of the gallbladder.
abstract: The records of 45 patients with carcinoma of the gallbladder who had undergone surgical resection at least 5 years previously were reviewed retrospectively to determine which factors influence long-term survival. Seventeen patients survived at least 5 years and 23 died from recurrence (five patients were excluded from analysis). Of the 17 long-term survivors 15 had tumours superficial to the subserosa that showed a non-infiltrative growth pattern. Those alive at 5 years were more likely than short-term survivors to have tumours that were papillary (P < 0.05) or well differentiated (P < 0.01) adenocarcinoma. Venous, lymphatic and perineural invasion was more common in short- than in long-term survivors (87 versus 29 per cent, P < 0.001). Patients with tumours limited to the muscularis and those with non-infiltrative subserosal involvement are likely to have better survival and may have a chance of cure after extended cholecystectomy.
authors: Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
authors: K
authors: K
authors: Ouchi
authors: M
authors: M
authors: Suzuki
authors: T
authors: T
authors: Tominaga
authors: S
authors: S
authors: Saijo
authors: S
authors: S
authors: Matsuno
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002763:Cholecystectomy / Q000379:methods* / Q000401:mortality; D005260:Female; D005706:Gallbladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies