title: [Autoimmune paraneoplastic cerebellar degeneration].
abstract: Paraneoplastic cerebellar degeneration is a well-defined clinical entity typically associated with ovarian or breast carcinoma. Serum or CSF of these patients has been shown to contain autoantibodies against the cytoplasm of Purkinje cells. These antibodies have been referred to as anti-Yo. We report the case of a 67-year old woman with ovarian adenocarcinoma presenting with subacute cerebellar dysfunction. Her serum was found to react with the cytoplasm of Purkinje cells and HeLa cells. On Western blot analysis a 60 to 70 kD reaction was obtained. This suggests the presence of a classical anti-Yo antibody.
authors: Service de Neurologie, CHUV, Lausanne, Suisse.
authors: K O
authors: KO
authors: Lövblad
authors: C
authors: C
authors: Henny
authors: J
authors: J
authors: Boucraut
authors: F
authors: F
authors: Graus
authors: J F
authors: JF
authors: Delaloye
authors: D
authors: D
authors: Bernard
authors: A J
authors: AJ
authors: Steck
authors: F
authors: F
authors: Regli
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D001327:Autoimmune Diseases; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000276:immunology; D011689:Purkinje Cells / Q000276:immunology; D013132:Spinocerebellar Degenerations / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014407:Tumor Cells, Cultured
vernacular_title: Dégénérescence cérébelleuse paranéoplasique auto-immune.