title: Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin.
abstract: OBJECTIVE
  To determine the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene in several ethnic groups: Caucasian Europeans, Black Nigerians, Samoan Polynesians and Yanomami Indians.
  
  
  RESULTS
  The ratio of the frequencies of the II, ID and DD genotypes were 1:2:1 in the Europeans, but there was a tendency towards a higher frequency of the D allele in the Nigerians. In contrast, the Samoans and the Yanomami Indians displayed a much higher frequency of the I allele than of the D allele.
  
  
  CONCLUSIONS
  The relationship between ACE genotype and disease in these latter groups is still not known, but the present results clearly suggest that ethnic origin should be carefully considered in the increasing number of studies on the association between I/D ACE genotype and disease aetiology.
authors: Medical Genetics Unit, St George's Hospital Medical School, London, UK.
authors: J
authors: J
authors: Barley
authors: A
authors: A
authors: Blackwood
authors: N D
authors: ND
authors: Carter
authors: D E
authors: DE
authors: Crews
authors: J K
authors: JK
authors: Cruickshank
authors: S
authors: S
authors: Jeffery
authors: A O
authors: AO
authors: Ogunlesi
authors: G A
authors: GA
authors: Sagnella
mesh_terms: D000483:Alleles; D044383:Black People; D004251:DNA Transposable Elements; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D014905:Independent State of Samoa / Q000208:ethnology; D007199:Indians, South American; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D044469:Racial Groups / Q000235:genetics*; D044465:White People
chemical_list: D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A