Propofol injection pain: comparing the addition of lignocaine or metoclopramide.
Lignocaine has been shown to reduce the incidence of pain on injection of propofol. Metoclopramide, a weak local anaesthetic and commonly used antiemetic, was combined with propofol and the mixture compared, in a prospective, randomized trial, with a lignocaine-propofol combination. The incidence of injection pain was similar in both groups, as were recovery times and incidence of vomiting. The metoclopramide-propofol group experienced a lower incidence of nausea. One patient in the metoclopramide-propofol group had a minor extrapyramidal reaction. No adverse local or haemodynamic effects were seen.
Mecklem
D W
DW
Department of Anaesthesia and Intensive Care, Cairns Base Hospital, Queensland.
D000328:Adult; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D005116:Extrapyramidal Tracts / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous / Q000009:adverse effects; D008012:Lidocaine / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage* / Q000494:pharmacology; D009325:Nausea / Q000209:etiology; D010146:Pain / Q000517:prevention & control*; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D011674:Pulse / Q000187:drug effects; D016037:Single-Blind Method; D014839:Vomiting / Q000209:etiology
D008012:Lidocaine; D008787:Metoclopramide; D015742:Propofol