Intracerebral co-grafting of Schwann's cells and fetal adrenal medulla in the treatment of Parkinson's disease.
Intracerebral co-grafting of Schwann's cells and human fetal adrenal medullary tissue was performed in 10 patients with Parkinson's disease. One to six months after grafting, symptoms were improved significantly for 1 to 3 grade. Among them, 2 patients resumed nearly normal daily activities. Long-term follow-up showed that the symptoms were not improved satisfactorily in some patients. It is considered that careful selection of patients, administration of amantadine, and co-grafting of Schwann's cells which prompts the survival of chromaffin cells are essential to better results.
Zhang
W C
WC
Department of Neurological Surgery, Xuanwu Hospital, Beijing.
Ding
Y J
YJ
Cao
J K
JK
Du
J X
JX
Zhang
G F
GF
Liu
Y J
YJ
D000313:Adrenal Medulla / Q000196:embryology / Q000637:transplantation*; D000328:Adult; D000547:Amantadine / Q000627:therapeutic use; D001921:Brain / Q000601:surgery*; D016380:Brain Tissue Transplantation; D005260:Female; D016332:Fetal Tissue Transplantation; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery*; D012583:Schwann Cells / Q000637:transplantation*; D013497:Sural Nerve / Q000473:pathology
D000547:Amantadine