[Trace elements balance in treated phenylketonuria children. Consequences of selenium deficiency on lipid peroxidation].
We studied Ca and Mg and trace elements (Zn, Cu, Fe, Mn, Se) in 15 P.K.U. children treated with strict Phe-reduced diet and in a control group. P.K.U. children are significantly lower (p < 0.01) plasma and erythrocyte Se as well as significantly lower (p < 0.01) activities of Glutathione-Peroxidase (GSH-Px), a seleno-dependent enzyme in erythrocytes and in plasma. Concomitantly with defective GSH-Px activities we observe significantly (p < 0.01) increased levels of lipid peroxidation products: malonaldialdehyde (MDA) and organic hydroperoxides (O.H.P.). So, Se supplementation appears to be necessary in low phenylalanine products used in P.K.U. treatment.
Wilke
B C
BC
Service de Pédiatrie 3, C.H.U. de Nancy.
Vidailhet
M
M
Richard
M J
MJ
Ducros
V
V
Arnaud
J
J
Favier
A
A
D002648:Child; D002675:Child, Preschool; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007223:Infant; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010649:Phenylalanine / Q000008:administration & dosage; D010661:Phenylketonurias / Q000097:blood* / Q000628:therapy; D012643:Selenium / Q000097:blood / Q000172:deficiency*; D014131:Trace Elements / Q000097:blood*
D014131:Trace Elements; D010649:Phenylalanine; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D012643:Selenium
Equilibre des oligoelements chez l'enfant phenylcetonurique traite. Consequences de la carence en selenium sur la peroxidation lipidique.