Changes in Na and K ions in mouse liver following in vivo exposure to ultrasound.
Mouse liver was exposed in vivo to a continuous and unfocussed ultrasound of 875 KHz at 5, 10 or 15 W/cm2 for 300 sec spread over five days and excised on day 0, 1, 5 and 10 for studying the changes in Na+ and K+ reserves and Na-K-ATPase activity. At 5 and 10 W intensities the change in ionic concentrations and Na-K-ATPase activity were almost in linear. At 15 W intensity the loss of both the ions and suppression of Na-K-ATPase indicated the damage of hepatic tissue caused by high intensity ultrasound. By day 10, all the animals of three exposures showed a normal ionic concentration with an optimum Na-K-ATPase activity in liver indicating the recovery process. The results indicate that ultrasound induces permeability changes in a glandular tissue exposed in vivo.
Varma
B M
BM
Department of Zoology, Sri Krishnadevaraya University, Anantapur, India.
Nath
B S
BS
Kumar
R P
RP
D000818:Animals; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D051379:Mice; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014463:Ultrasonography
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium