Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains.
By employing multiprobe oligonucleotide solution hybridisation (MOSH) we have measured the levels of mRNA encoding the NMDA receptor subtypes (R1, R2A, R2B and R2C) and the non-NMDA glutamate receptor subtypes (GluR1, 2, 3, and 4) within rat brain following, 1-32 days of antipsychotic or antidepressant drug administration. The results suggest that the drugs studied do not significantly alter rat glutamatergic system mRNA levels when compared to controls.
Oretti
R G
RG
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Spurlock
G
G
Buckland
P R
PR
McGuffin
P
P
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001483:Base Sequence; D001923:Brain Chemistry / Q000187:drug effects*; D015283:Citalopram / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics; D012559:Schizophrenia; D013469:Sulpiride / Q000494:pharmacology
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D015283:Citalopram; D008803:Mianserin; D013469:Sulpiride; D003024:Clozapine; D006220:Haloperidol