In vitro antibacterial activity of sucralfate.
The effect of sucralfate (12.5 mg/ml) on the growth of Escherichia coli (ATCC 25922), Enterococcus faecalis (ATCC 29212) and two isolates of Pseudomonas aeruginosa (ATCC 27853 and a multi-resistant clinical isolate) was studied in vitro at pH values of 3.0, 4.5, 6.0 and 7.4. A bacteriostatic effect of sucralfate was demonstrated for Pseudomonas aeruginosa at a pH of 6.0 and 7.4 and for Escherichia coli and Enterococcus faecalis at a pH of 6.0. The bacteriostatic effect was most pronounced at high pH values. Sucralfate had no bactericidal effect on the bacteria tested at the concentration used.
Bergmans
D
D
Department of Medical Microbiology, University Hospital Maastricht, The Netherlands.
Bonten
M
M
Gaillard
C
C
van Tiel
F
F
van der Geest
S
S
Stobberingh
E
E
D001419:Bacteria / Q000187:drug effects*; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013392:Sucralfate / Q000494:pharmacology*
D013392:Sucralfate