[Anti-hypoxia and anti-glucose deficiency effects of PQS on guinea pig papillary muscle in low frequency electrical stimulation].
Panax quinquefolium saponin (PQS) increases the contractibility of papillary muscle of guinea pigs during electrical stimulation with frequency of 1/8-1/64Hz (P < 0.05). In Krebs-Henseleit solution purged with gas containing 95% N2 and 5% CO2 regardless of containing glucose or not, PQS (0.3mg/kg) has the effect of anti-hypoxia and anti-glucose deficiency (P < 0.05, P < 0.01) in the electrical stimulation with frequency of 1/8-1/64Hz.
Yang
S J
SJ
Norman Bethune University of Medical Sciences, changchun.
Li
H
H
Wang
Q J
QJ
Takeya
K
K
D000818:Animals; D015687:Cell Hypoxia; D036145:Ginsenosides; D005947:Glucose / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D005894:Panax / Q000737:chemistry*; D010210:Papillary Muscles / Q000187:drug effects; D010946:Plants, Medicinal; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D036145:Ginsenosides; D012503:Saponins; D005947:Glucose