Lithium- and carbamazepine-associated sinus node dysfunction: nine-year experience in a psychiatric hospital.
The cardiac effects of lithium and carbamazepine are considered rare, but both are known to induce sinus node dysfunction. The author presents the 9-year experience in a state mental hospital with lithium-induced sinus node dysfunction. Four of the five patients were also on carbamazepine. The clinical features of previously reported cases of lithium- and carbamazepine-associated sinus node dysfunction are reviewed. A role for carbamazepine in lithium-induced sinus node dysfunction is discussed.
Steckler
T L
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Department of Mental Health and Mental Retardation, Western State Hospital, Staunton, Virginia.
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D012804:Sick Sinus Syndrome / Q000097:blood / Q000139:chemically induced*
D016651:Lithium Carbonate; D002220:Carbamazepine