Adult height exceeding target height in a patient with congenital panhypopituitarism diagnosed after the age of 25 years.
This case report concerns a prepubertal patient (height 148.7 cm) with congenital anterior panhypopituitarism diagnosed at the chronological age of 25.2 years (bone age 12.5). In spite of his advanced age on initiation of hormonal replacement therapy this patient achieved an adult height (172.8 cm), exceeding those of his father and brothers, because of his markedly delayed bone age. This satisfactory height outcome confirms that final height in hypopituitarism depends on both height at onset of puberty and height with respect to bone age but not chronological age at initiation of growth hormone treatment.
Arrigo
T
T
Institute of Pediatrics, University Hospital, Messina, Italy.
Crisafulli
G
G
Salamone
A
A
Cucinotta
D
D
De Luca
F
F
D000328:Adult; D000365:Age Determination by Skeleton; D001827:Body Height; D003692:Delayed-Action Preparations; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D007018:Hypopituitarism / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D013739:Testosterone / Q000627:therapeutic use; D013974:Thyroxine / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D013739:Testosterone; D013006:Growth Hormone; D013974:Thyroxine; D006854:Hydrocortisone