Future directions in pediatric epileptology.
Rapid developments in several areas of epileptology alter or clarify concepts and bring new hope to epileptic patients and their associates. Brief discussions of such advances comprise this report. Experimental and clinical data concerning the pathogenesis of cognitive impairment in some epileptic conditions are reviewed. Epidemiologic studies have altered some long-held concepts concerning etiology of seizures in early life. Molecular genetic studies have disclosed abnormalities in some of the epilepsies: a genetic predisposition to epilepsy may explain why some patients with cortical lesions develop seizures and others do not. It is suggested that many questions regarding surgery in pediatric epilepsy will be resolved only by more reliable techniques of case selection and follow-up. Practitioners in developed countries must realize how rudimentary is the care given to the unfortunate many with seizure disorders in less advantaged areas.
Blume
W T
WT
University Hospital, Epilepsy Unit, University of Western Ontario, London, Canada.
D000927:Anticonvulsants / Q000627:therapeutic use; D001925:Brain Damage, Chronic / Q000209:etiology / Q000235:genetics / Q000628:therapy; D002648:Child; D003337:Corpus Callosum / Q000601:surgery; D004827:Epilepsy / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D011612:Psychosurgery; D012307:Risk Factors
D000927:Anticonvulsants