title: [New acetylcholinesterase inhibitors--derivatives of vitamin B6].
abstract: A new approach to design of reversible inhibitors of acetylcholinesterase (ACHE)--derivatives of natural compounds--has been worked out, as exemplified by vitamins of the B6 group. Analysis of the data obtained revealed main structural elements of the 3-hydroxypyridine molecule related to the inhibitory properties. Pyridoxamine derivatives are of interest in constructing new potent inhibitors of ACHE.
authors: M Ia
authors: MIa
authors: Karpeĭskiĭ
authors: N Sh
authors: NSh
authors: Padiukova
authors: V P
authors: VP
authors: Varlamov
authors: G E
authors: GE
authors: Bannikova
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D011736:Pyridoxine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014101:Torpedo
chemical_list: D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase; D011736:Pyridoxine
vernacular_title: Novye ingibitory atsetilkholinésterazy--proizvodnye vitamina B6.