Epstein-Barr virus in familial Hodgkin's disease.
Hodgkin's disease (HD) has been found to be linked to Epstein-Barr virus (EBV). Familial HD (FHD) may be related to a possible unknown agent. We have determined whether EBV small RNAs (EBERs) were found in Reed-Sternberg cells from FHD. Five families were studied for histological subtype and EBER presence. There was a striking similarity in FHD subtypes of each family and 3/11 (27%) of the cases were EBER positive. In conclusion, EBV EBERs are only infrequently found in FHD and other factors including viruses different from EBV should be further investigated in FHD.
Schlaifer
D
D
Service d'Hématologie, Hôpital de Purpan, Toulouse, France.
Rigal-Huguet
F
F
Robert
A
A
Attal
M
M
Abbal
M
M
Fonck
Y
Y
Laurent
G
G
Pris
J
J
Delsol
G
G
Brousset
P
P
D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000235:genetics / Q000821:virology*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D010375:Pedigree; D012367:RNA, Viral / Q000032:analysis
D012367:RNA, Viral