title: Interactive and discontinuous long-lasting potentiation in the dentate gyrus.
abstract: Non-overlapping applications of l-isoproterenol, a beta-adrenergic agonist, and the neuropeptide cholecystokinin 8-S produce long-lasting potentiation of evoked action potentials in the dentate gyrus. There is no corresponding modification of excitatory post-synaptic potentials. This effect, referred to as interactive long-lasting potentiation, is pharmacologically similar to the long-lasting potentiation produced by discontinuous or non-overlapping applications of l-isoproterenol. Metoprolol or propranolol, both beta-adrenergic antagonists, prevent interactive long-lasting potentiation, but D-amino-5-phosphonopentanoic acid, an N-methyl-D-aspartate receptor antagonist, does not. Cholecystokinin 8-S and beta-adrenergic receptors may activate a common intermediate in the interactive paradigm.
authors: School of Human Development, University of Texas at Dallas, Richardson 75080.
authors: D
authors: D
authors: Dahl
authors: J
authors: J
authors: Li
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000494:pharmacology
chemical_list: D015763:2-Amino-5-phosphonovalerate; D011433:Propranolol; D008790:Metoprolol; D007545:Isoproterenol; D012844:Sincalide