The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA.
A 2618-bp cDNA that encodes the human mitochondrial glycerol-3-phosphate dehydrogenase has been isolated from a HeLa cell cDNA library and the nucleotide sequence determined. An open reading frame encodes a protein of 727 amino acids that is 96% similar to the rat protein and, like the rat protein, contains sites homologous to the Ca(2+)-binding sites of calmodulin, as well as FAD- and putative glycerol-phosphate-binding sites.
Lehn
D A
DA
University of Wisconsin Childrens Diabetes Center, Madison 53706.
Brown
L J
LJ
Simonson
G D
GD
Moran
S M
SM
MacDonald
M J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism; D018076:DNA, Complementary; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D015723:Gene Library; D005993:Glycerolphosphate Dehydrogenase / Q000235:genetics*; D005994:Glycerophosphates / Q000378:metabolism; D006367:HeLa Cells; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D051381:Rats; D017386:Sequence Homology, Amino Acid
D002147:Calmodulin; D018076:DNA, Complementary; D005994:Glycerophosphates; D005182:Flavin-Adenine Dinucleotide; D005993:Glycerolphosphate Dehydrogenase; D002118:Calcium