Antianxiety actions of Ca2+ channel antagonists with Vogel-type conflict test in rats.
We examined the effects of various derivatives of Ca2+ channel antagonists in a modified rat Vogel-type conflict model. Flunarizine (10 and 20 mg/kg), nicardipine (20 mg/kg), and verapamil (20 mg/kg), given as single i.p. injections, significantly increased punished lickings by 50-110%. Chronic administration of diltiazem, at 20 mg/kg i.p. for 8 days, a dose ineffective with a single i.p. injection, produced a significant anticonflict action. The possibility that Ca2+ channel antagonists have anxiolytic action should be considered.
Matsumoto
Y
Y
Department of Pharmacology, School Nurse Training, Kyushu Women's Jr. College, Japan.
Kataoka
Y
Y
Watanabe
Y
Y
Miyazaki
A
A
Taniyama
K
K
D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004558:Electric Stimulation; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002121:Calcium Channel Blockers; D002118:Calcium