Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease.
Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD.
Lucotte
G
G
Regional Center of Neurogenetics, CHR of Reims, France.
Visvikis
S
S
Leininger-Müler
B
B
David
F
F
Berriche
S
S
Réveilleau
S
S
Couderc
R
R
Babron
M C
MC
Aguillon
D
D
Siest
G
G
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D013997:Time Factors
D001057:Apolipoproteins E; D004247:DNA