title: Clomiphene citrate reduces procarbazine-induced sterility in a rat model.
abstract: Chemotherapy with the cytotoxic drug procarbazine (PCB) causes permanent infertility in most male patients. Since many patients treated with this cytotoxic drug are of reproductive age, it is important to develop a method to protect spermatogenesis and fertility. It has been hypothesised that 'spermatogenic arrest' by pharmacological intervention may render the testes less susceptible to the effects of chemotherapy. The present study investigated whether recovery of fertility in a male rat model could be achieved by suppression of spermatogenesis with high doses of clomiphene citrate (CC) prior to PCB administration. It was demonstrated that young male rats treated with a combination of CC and PCB partially recovered spermatogenesis and achieved almost normal fertility. In contrast, animals treated with PCB alone exhibited abnormal spermatogenesis and remained infertile.
authors: Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Israel.
authors: R
authors: R
authors: Weissenberg
authors: M
authors: M
authors: Lahav
authors: P
authors: P
authors: Raanani
authors: R
authors: R
authors: Singer
authors: A
authors: A
authors: Regev
authors: M
authors: M
authors: Sagiv
authors: S
authors: S
authors: Giler
authors: E
authors: E
authors: Theodor
mesh_terms: D000818:Animals; D002996:Clomiphene / Q000494:pharmacology*; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D011344:Procarbazine / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000473:pathology
chemical_list: D002996:Clomiphene; D011344:Procarbazine