[The effect of diuretics on the magnitude of the effect of isosorbide dinitrate given as a single dose and after long-term administration. Ergometric study in patients with stable angina pectoris].
The authors assessed in 24 men with stable angina pectoris, using means of ergometry, the antiischaemic and antianginose effects of a combination of the nitrate Iso-Mack retard and the diuretic Moduretic. The effects were compared with the effects of Iso-Mack retard administered alone and with the effects of placebo. The examination was made after a single dose of the drugs and after three-week administration. The authors revealed that a single dose of the diuretic significantly enhanced the effects of nitrate. During long-term administration the diuretic did not prevent a significant diminution of the nitrate effects. Finally the authors discuss possible mechanisms of development of tolerance for nitrates and possibilities how to influence this tolerance by a diuretic.
Rotrekl
P
P
I. interní klinika FNsP Brno-Bohunice.
Vlasínová
J
J
Manousek
J
J
Bocek
O
O
Vlasicová
Y
Y
Janousek
S
S
Semrád
B
B
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D004357:Drug Synergism; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method
D006852:Hydrochlorothiazide; D007548:Isosorbide Dinitrate
Vliv diuretika na velikost úcinku isosorbiddinitrátu pri jednorázovém a dlouhodobém podávání. Ergometrická studie u pacientů se stabilní anginou pectoris.