title: Rheumatoid nodules located in the penis of a methotrexate-treated patient with rheumatoid arthritis.
abstract: A case is reported in which a patient with a rheumatoid factor-negative rheumatoid arthritis developed rheumatoid nodules in the penis during treatment with methotrexate. The development of rheumatoid nodules in seronegative rheumatoid arthritis patients is extremely rare. An acceleration of rheumatoid nodules in methotrexate-treated rheumatoid arthritis patients is reported in literature. Regarding the case reported here, we propose a causal relationship between methotrexate-treatment and the development of rheumatoid nodules in our patient. Methotrexate should not be the preferential treatment for patients with rheumatoid arthritis developing rheumatoid nodules and suffering from vasculitis.
authors: I. Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität Mainz.
authors: K M
authors: KM
authors: Essig
authors: W J
authors: WJ
authors: Mayet
authors: A M
authors: AM
authors: Mottrie
authors: I
authors: I
authors: Helmreich-Becker
authors: K H
authors: KH
authors: Meyer zum Büschenfelde
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009336:Necrosis; D010409:Penile Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D010413:Penis / Q000473:pathology; D012217:Rheumatoid Factor / Q000097:blood; D012218:Rheumatoid Nodule / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
chemical_list: D012217:Rheumatoid Factor; D008727:Methotrexate