Role of bacteria-specific T cells in the immunopathogenesis of reactive arthritis.
Reactive arthritis is a usually self-limited sterile inflammation of joints that follows certain bacterial gastrointestinal or urogenital infections. The immunopathogenesis involves CD4+ T cells, which mediate an antigen-specific TH1 response to bacterial constituents within the joint. Properties of the arthritogenic bacteria and the physicochemical characteristics of the bacterial antigens may contribute to the development of reactive arthritis.
Probst
P
P
Bernhard-Nocht Institute for Tropical Medicine, Germany.
Hermann
E
E
Fleischer
B
B
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D016918:Arthritis, Reactive / Q000276:immunology* / Q000382:microbiology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D051381:Rats; D012480:Salmonella Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D015009:Yersinia Infections / Q000276:immunology
D000942:Antigens, Bacterial