Increased levels of antibodies to food proteins in Down syndrome.
An increased level of immunoglobulin A (IgA) antibodies to food antigens has been found in Down syndrome. Biopsy did not show any anomaly of the gut. Increased IgA levels against specific proteins reflect increased transmucosal transport of antigens. The antigens presented may be immunogenic peptides or intact antigens. In this paper, we wished to exclude an institutional cause such as infections and also age differences.
Reichelt
K L
KL
Department of Pediatric Research, National Hospital, Rikshospitalet, Oslo, Norway.
Lindback
T
T
Scott
H
H
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004044:Dietary Proteins / Q000276:immunology*; D004314:Down Syndrome / Q000276:immunology*; D005260:Female; D005903:Gliadin / Q000276:immunology; D005983:Glutens / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged
D000888:Antibodies, Anti-Idiotypic; D004044:Dietary Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005983:Glutens; D005903:Gliadin