Effects of intensive exercise training on lipid levels in high risk post-MI patients.
One hundred and two patients participated in a 4 week programme of intensive exercise training early after myocardial infarction. Lipid levels were measured before and after exercise training. The mean exercise capacity increased by 49% (P = 0.0001). Twenty-one patients who continued smoking and 25 non-beta-blocked patients were considered to have an increased risk of recurrent cardiac events, as were patients with high initial lipid levels. In the smokers and non-beta-blocked patients total cholesterol decreased by 0.30 mmol.l-1 (P = 0.031) and 0.37 mmol.l-1 (P = 0.042) respectively and triglycerides by 0.28 mmol.l-1 (P = 0.058) and 0.13 mmol.l-1 (P = 0.11). Patients with high initial cholesterol and triglyceride levels had the largest cholesterol and triglyceride decrease, r = 0.43 (P = 0.0001) and r = 0.38 (P = 0.001) respectively. After adjusting for initial lipid levels, cholesterol (P = 0.036) as well as triglycerides (P = 0.034) decreased in patients without beta-blocker treatment whereas smoking no longer had an independent effect on lipid level decrease. HDL-cholesterol did not change in any group. Thus, after 4 weeks of exercise training lipid profiles were improved in patients with an increased risk of recurrent cardiac events. Beta-blocker treatment, however, seemed to hinder the beneficial effects of exercise training on lipid levels.
Heldal
M
M
Department of Medicine, Aker University Hospital, Oslo, Norway.
Sire
S
S
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D000075202:Contraindications; D005081:Exercise Therapy; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000534:rehabilitation*; D012008:Recurrence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D000319:Adrenergic beta-Antagonists; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol