Studies regarding a fibrosarcoma induced in Sprague-Dawley rats by a murine cytomegalovirus. Note I. Aspects related to the character and reproduction of the tumor.
Through passages on Sprague-Dawley rats (performed during seven years) the serial transmissibility of a fibrosarcoma type tumor, with a tendency to local recurrence and locoregional metastasis formation, is demonstrated. The tumor was initially obtained by in vitro transformation of primary total rat embryonic cultures under the influence of a murine cytomegalovirus (M-CMV). In the course of passages, susceptible (S) and resistant (R) animal lines to the respective tumor could be obtained. The R and S crossings demonstrated the dominant transmission of S.
Lupu
A
A
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Iftimovici
R
R
Jucu
V
V
Prodescu
S T
ST
D000818:Animals; D002472:Cell Transformation, Viral; D003587:Cytomegalovirus / Q000472:pathogenicity*; D004198:Disease Susceptibility; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology* / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012692:Serial Passage; D013997:Time Factors