[Neurogenic pain syndromes and their pathogenetic therapy].
Analgesic effects of morphine, clofelin, sirdalud, propranolol, and verapamil were studied in animals with the neurogenic painful syndrome induced by cutting the sciatic nerve and in patients with phantom painful syndrome after limb amputation. In animals with cut sciatic nerve morphine not only failed to prevent neurogenic pain, but was conducive to its increase. And, on the contrary, nontraditional analgesics clofelin, sirdalud, propranolol, and verapamil showed a high therapeutic efficacy both in experiments and in clinical trials. The results are discussed from the viewpoint of pathogenetic mechanisms of development of neurogenic painful syndromes.
Kukushkin
M L
ML
Reshetniak
V K
VK
Vorobeĭchik
Ia M
IaM
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000818:Animals; D003000:Clonidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010591:Phantom Limb / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve; D013577:Syndrome; D014700:Verapamil / Q000627:therapeutic use
D000700:Analgesics; D000701:Analgesics, Opioid; C023754:tizanidine; D009020:Morphine; D011433:Propranolol; D014700:Verapamil; D003000:Clonidine
Neĭrogennye bolevye sindromy i ikh patogeneticheskaia terapiia.