The brain tryptophan hydroxylase activity in the sleep-like states in frog.
The activity of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, was determined in the brain stem in active awake frogs, and frogs in three sleep-like states: with plastic muscle tone (SLS-1), with rigid muscle tone (SLS-2), and with relaxed muscle tone (SLS-3). Significant decrease in the enzyme activity has been found in frogs in SLS-1 and SLS-2 compared to awake animals. The development in frogs a cataleptic-like immobility after treating the animals with rhythmic lighting was accompanied with a decrease in the brain tryptophan hydroxylase activity. These results provide strong evidence for the involvement of the brain serotonin in frogs in the control of evolutionary ancient sleep-like states, probably by the regulation of muscle tone.
Kulikov
A V
AV
Institute of Cytology & Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk.
Karmanova
I G
IG
Kozlachkova
E Y
EY
Voronova
I P
IP
Popova
N K
NK
D000818:Animals; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002375:Catalepsy / Q000201:enzymology; D006990:Hypnosis; D009129:Muscle Tonus / Q000502:physiology; D011895:Rana ridibunda; D012890:Sleep / Q000502:physiology*; D014365:Tryptophan Hydroxylase / Q000378:metabolism*; D014851:Wakefulness / Q000502:physiology
D014365:Tryptophan Hydroxylase