Phylogenetic analysis of the rpoB gene from the plastid-like DNA of Plasmodium falciparum.
Malaria and other Apicomplexan parasites harbour two extrachromosomal DNAs. One is mitochondrial and the other is a 35-kb circle with some plastid-like features but whose provenance and function is unknown. In addition to genes for rRNAs, tRNAs and ribosomal proteins, the 35-kb circular DNA of Plasmodium falciparum carries an rpoBC operon which encodes subunits of a eubacteria-like RNA polymerase. The phylogenetic analysis of the complete rpoB sequence presented here supports our inference that the 35-kb circle is the remnant of a plastid genome.
Gardner
M J
MJ
Parasitology Division, National Institute for Medical Research, Mill Hill, London, UK.
Goldman
N
N
Barnett
P
P
Moore
P W
PW
Rangachari
K
K
Strath
M
M
Whyte
A
A
Williamson
D H
DH
Wilson
R J
RJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003062:Codon / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D004270:DNA, Circular / Q000235:genetics; D016054:DNA, Protozoan / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D005111:Extrachromosomal Inheritance; D017125:Genes, Protozoan; D008969:Molecular Sequence Data; D010802:Phylogeny; D010963:Plasmodium falciparum / Q000201:enzymology / Q000235:genetics*; D018087:Plastids / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D003062:Codon; D017931:DNA Primers; D004270:DNA, Circular; D016054:DNA, Protozoan; D012321:DNA-Directed RNA Polymerases