[Synthesis and comparative analysis of antigenic activity of peptides from hypervariable region V3 of human immunodeficiency virus I gp120 surface glycoprotein].
A set of peptides (amino acid positions 10-23) corresponding to seven most widely spread variants of the gp120 V3 domain in the HIV-infected population of South Russia were prepared by the solid-phase synthesis. A laboratory variant of the indirect enzyme-linked immunosorbent assay (ELISA) was developed for the determination of V3 specific antibodies with use of the peptides synthesized. The analysis of the V3-specific antibodies in HIV-infected using the elaborated test-system revealed a correlation between the V3 variants distribution and the occurrence of antibodies against these variants.
Semiletov
Iu A
IuA
Rzhaninova
A A
AA
Garaev
M M
MM
D000595:Amino Acid Sequence; D004797:Enzyme-Linked Immunosorbent Assay; D015488:HIV Antigens / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D015497:HIV-1 / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology*
D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D007135:Immunoglobulin Variable Region; D010446:Peptide Fragments
Sintez i sravnitel'nyĭ analiz antigennoĭ aktivnosti peptidov gipervariable'noĭ oblasti V3 poverkhnostnogo glikoproteida gp120 virusa immunodefitsita cheloveka tipa I.