Identification of multiple transcribed sequences from the spinal muscular atrophy region of human chromosome 5.
We report the isolation and characterization of novel expressed sequences from the spinal muscular atrophy (SMA) region on human chromosome 5q13. Based on the sequence homology studies these cDNAs were grouped in four classes, one of which shows extensive homologies with the beta-glucuronidase (BG) gene, differing in exon arrangement. The other cDNAs do not show any strong homology with known DNA sequences.
Pizzuti
A
A
Istituto di Neurologia, Università di Milano, Italy.
Colosimo
A
A
Ratti
A
A
Capon
F
F
Gennarelli
M
M
Silani
V
V
Ghezzi
C
C
Lo Cicero
S
S
Calabrese
G
G
Palka
G
G
D001483:Base Sequence; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002895:Chromosomes, Human, Pair 5; D003360:Cosmids; D018076:DNA, Complementary; D005091:Exons; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009134:Muscular Atrophy, Spinal / Q000235:genetics*; D009838:Oligodeoxyribonucleotides; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
D018076:DNA, Complementary; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; D005966:Glucuronidase