title: Phylogenetic relationships among Homo sapiens and related species based on restriction site variations in rDNA spacers.
abstract: A rapid method, using 12 restriction enzymes, was employed to analyze variations in ribosomal DNA (rDNA) spacers in a study of phylogenetic relationships between Homo sapiens and related species. We mapped restriction sites in the external and internal spacer regions and compared the arrangements of sites. The estimated sequence divergence between Homo sapiens and Pan troglodytes, Pan paniscus, Gorilla gorilla, Pongo pygmaeus, Hylobates lar, H. agilis, and Macaca fuscata was 2.7, 2.3, 3.8, 7.3, 6.8, 7.8, and 14.1%, respectively. The genetic relationships inferred from these distances generally correspond to those inferred from analyses of other molecular markers in the literature. The divergence between H. lar and H. agilis and between H. lar and H. syndactylus was 0.34 and 2.4%, respectively.
authors: Division of Molecular Genetics, Jikei University School of Medicine, Tokyo, Japan.
authors: H
authors: H
authors: Suzuki
authors: Y
authors: Y
authors: Kawamoto
authors: O
authors: O
authors: Takenaka
authors: I
authors: I
authors: Munechika
authors: H
authors: H
authors: Hori
authors: S
authors: S
authors: Sakurai
mesh_terms: D000818:Animals; D004275:DNA, Ribosomal / Q000097:blood / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D006922:Hylobates / Q000235:genetics; D008251:Macaca / Q000235:genetics; D010802:Phylogeny; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D004275:DNA, Ribosomal