TSH response to TRH and ECT.
In 31 female patients diagnosed according to DSM-III-R criteria as suffering from 'functional' psychosis (e.g., major depression, schizophrenia, mania) TRH tests were administered before, during and after a course of electroconvulsive therapy (ECT) to investigate the effects of ECT on HPT (hypothalamic-pituitary-thyroid) axis as well as the predictive value of TSH response to TRH on treatment outcome. In 20 patients all three TRH tests were available; no significant changes in the mean TSH response were found over the course of ECT; however, a change towards blunted TSH response at the end of treatment was observed. The initial TSH response did not predict the treatment outcome.
Hofmann
P
P
Department of Psychiatry, University Hospital Graz, Austria.
Gangadhar
B N
BN
Probst
C
C
Koinig
G
G
Hatzinger
R
R
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000523:psychology / Q000628:therapy*; D003866:Depressive Disorder / Q000097:blood / Q000523:psychology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood / Q000628:therapy*; D012565:Schizophrenic Psychology; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone; D016896:Treatment Outcome
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin