Recent developments in the radiobiology of cellular membranes.
We have reviewed the literature on cellular membrane radiobiology over the last ten years and, in particular, report on the development of rapid techniques used to identify damage soon after irradiation. It is clear that damage can now be quantified after low doses, and further refinements can be expected. From the work summarised, it would appear that changes to membranes at low doses may occur soon after damage to other important macromolecules by intercommunicating processes. We believe that there now exists a variety of rapid methods of measuring deposition of damage in vital macromolecules, such as cellular membranes and DNA, which can give a fuller picture of the overall effects of radiation and lead to predictions of eventual cellular mortality.
Cramp
W A
WA
Division of Thermal and Radiation Oncology, Oregon Health Sciences University, Portland 97201.
Yatvin
M B
MB
Harms-Ringdahl
M
M
D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000528:radiation effects*; D006801:Humans; D011853:Radiobiology