title: Adaptive response to ionizing radiation in normal and aneuploid human lymphocytes.
abstract: The ability to induce an adaptive response by low doses of gamma rays was studied in normal and trisomic lymphocytes (47, XX or XY, +21). The results indicate the presence of an adaptive response in lymphocytes of 3 normal donors, but in lymphocytes of 5 donors with trisomy 21 no significant adaptive response after irradiation with a low dose of gamma rays was found. There was similar chromosomal radiosensitivity in normal and trisomic lymphocytes (47, XX or XY, +21) irradiated with 1.50 Gy at the 48th hour after stimulation.
authors: Department of Medical Biology, Medical Faculty, Safarik University, Kosice.
authors: I
authors: I
authors: Kalina
authors: H
authors: H
authors: Konecná
authors: G
authors: G
authors: Némethová
authors: N
authors: N
authors: Raceková
mesh_terms: D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004314:Down Syndrome / Q000473:pathology; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D011836:Radiation Tolerance / Q000502:physiology*; D014314:Trisomy