[Home therapy approach in cancer patients-chemotherapy (case 2-2)].
We have performed intra-arterial biochemical modulation chemotherapy of 5-FU with Leucovorin for patients with unresectable liver metastases from colorectal cancer. Three regimens were performed. A; weekly bolus injection of 5-FU and Leucovorin (6 cases), B; 7 days continuous injection of 5-FU after bolus injection of Leucovorin (4 cases), C; 5 days simultaneously continuous injection of 5-FU with Leucovorin (6 cases). The results were; response rate was A:0%, B:25%, C:33% and survival rate for patients of C method was better than that for patients of A and B method. Four patients complained mild nausea of less than Grade 2, but only one patient of C method. These results suggest that simultaneously continuous intra-arterial injection of 5-FU with Leucovorin is an excellent therapy for patients with unresectable liver metastases from colorectal cancer.
Yamamura
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First Dept. of Surgery St. Marianna University School of Medicine.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage; D018718:Home Infusion Therapy; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary
D002955:Leucovorin; D005472:Fluorouracil