[The mechanisms of the teratogenic action of alcohol].
Under study was the influence of different doses and methods of administration of ethanol on embryogenesis of rats and the effect of some shifts in homeostasis of a female rat on a manifestation of teratogenic effect of ethanol. Embryogenesis of rats is resistant to action of ethanol and acetaldehyde. Shift in the acid-base balance to the acid side is not thought to be determining in the mechanism of the appearance of the fetal alcohol syndrome, while the embryotoxic effect of ethanol manifests itself against the background of an iron-deficient state of the maternal organism.
Chebotar'
N A
NA
Konopistseva
L A
LA
D015082:2,2'-Dipyridyl / Q000633:toxicity; D000014:Abnormalities, Drug-Induced / Q000209:etiology* / Q000473:pathology; D018798:Anemia, Iron-Deficiency / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D004221:Disulfiram / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004622:Embryo, Mammalian / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D000431:Ethanol; D015082:2,2'-Dipyridyl; D004221:Disulfiram
Mekhanizmy teratogennogo deĭstviia alkogolia.