[The glutathione content and glutathione-S-transferase activity in the organs and blood of rats following chronic irradiation at low doses].
The effect of chronic low dose-rate irradiation with X-rays up to total doses of 2.58, 5.16, 6.46, 7.75, 10.32, 12.92 mC/kg on glutathione content and glutathione-S-transferase activity in Wistar rats organs, different by radiosensitivity, was studied 1 h after exposure. It has been shown that level of oxidized and reduced glutathione forms was not changed after exposure to 2.58 mC/kg, was enhanced in kidney and brain tissues after exposure to 5.16 and 6.46 mC/kg and was decreased in brain, lungs, small intestines and blood serum after ray exposures to higher doses. Inhibition of glutathione-S-transferase activity was found in liver, kidneys and spleen.
Reva
A D
AD
Zhivaliuk
O B
OB
Luk'ianenko
A I
AI
Egorova
E G
EG
Dvoretskiĭ
A I
AI
D000818:Animals; D002908:Chronic Disease; D004307:Dose-Response Relationship, Radiation; D005470:Fluorometry; D005978:Glutathione / Q000032:analysis / Q000528:radiation effects*; D005982:Glutathione Transferase / Q000032:analysis / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D011836:Radiation Tolerance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
D005982:Glutathione Transferase; D005978:Glutathione
Soderzhanie glutationa i aktivnost' glutation-S-transferazy v organakh i krovi krys posle khronicheskogo oblucheniia v malykh dozakh.