Quantitative and qualitative fluctuation of water in the mouse submandibular gland under secretagogue effect.
The short-term effects of two different secretagogues on the water contained in the mouse submandibular gland were studied using the thermal analysis as investigation method. Isoproterenol induced a retention while pilocarpine promoted a release of weakly and strongly bound water. In addition, submandibular glands of subjects administered with isoproterenol were characterized by a thermal behaviour different in males and females above all as concerns the time of reaction to the secretagogue; the reaction delay observed in females was correlated with the effects of this pharmacological substance on the convoluted granular tubules that are responsible for the sexual dimorphism in mice.
Materazzi
S
S
Dipartimento di Scienze Chimiche, Università La Sapienza, Roma, Italy.
Curini
R
R
Gabrielli
M G
MG
Fava
L
L
Menghi
G
G
D000818:Animals; D001834:Body Water / Q000378:metabolism*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010862:Pilocarpine / Q000494:pharmacology*; D012737:Sex Factors; D013363:Submandibular Gland / Q000187:drug effects / Q000502:physiology*; D013696:Temperature
D010862:Pilocarpine; D007545:Isoproterenol