A structure activity relationship study on 1-isopropylamino-3-(2'-substituted naphthoxy)-propan-2-ois analogs.
The structure activity relationship of 1-isopropylamino-3-(2'-substituted naphthoxy) propan-2-ois analogs, which are beta-adrenergic blocking drugs, is discussed. The blocking activity of these compounds is found to be dominantly controlled by electronic and steric factors. Significant correlations have been obtained between the blocking activity and negentropy, equalized eletronegativity and partial charge.
Srivastava
A K
AK
Department of Chemistry, University of Allahabad, India.
Mishra
N
N
Khan
A A
AA
Gupta
D K
DK
D000319:Adrenergic beta-Antagonists / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D006168:Guinea Pigs; D007545:Isoproterenol / Q000494:pharmacology; D007928:Lethal Dose 50; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009284:Naphthols / Q000737:chemistry* / Q000494:pharmacology; D011412:Propanolamines / Q000737:chemistry* / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013329:Structure-Activity Relationship; D014132:Trachea / Q000187:drug effects / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D009284:Naphthols; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol