Polymorphism of the gene encoding a human minimal potassium ion channel (minK).
A gene (minK) that encodes a minimal potassium channel has been cloned recently. We describe in this paper a human minK sequence which differs from the original sequence with a single A-->G at position 112. This resulted in a change from a Ser codon (AGT) to a Gly codon (GGT) and created a new MspAI restriction site. Of the 32 alleles from 16 subjects studied, 25 had this newly discovered sequence and 7 had the previously described sequence.
Lai
L P
LP
Department of Medicine, University of Rochester Medical Center, NY 14642.
Deng
C L
CL
Moss
A J
AJ
Kass
R S
RS
Liang
C S
CS
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002880:Chromosomes, Human, Pair 11; D003062:Codon / Q000235:genetics; D017931:DNA Primers; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D005998:Glycine; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015221:Potassium Channels / Q000235:genetics*; D024642:Potassium Channels, Voltage-Gated; D012694:Serine
D003062:Codon; D017931:DNA Primers; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; C059983:potassium channel protein I(sk); D012694:Serine; D005998:Glycine