[Short-term prophylaxis with ceftriaxone in planned intrathoracic operations].
The purpose of the investigation was to evaluate the effect of short-term prophylaxis with a cephalosporin of the IIIrd generation, ceftriaxone, in 20 patients with an elective intrathoracic operation. The investigation comprised patients operated on account of bronchogenic carcinoma, metastases in the lungs, relapsing spontaneous pneumothorax and carcinoma of the distal cesophagus. ceftriaxone - 1 g was administered before the introduction to anaesthesia. The second 1 g dose was administered after 12 hours. In addition to the microbiological examination of the bronchial secretion and evaluation of the minimal inhibitory concentration of ceftriaxone to the isolated bacteria the ceftriaxone serum level was assessed in the patients and its concentration in the pulmonary parenchyma. Postoperative inflammatory complications/pneumonia/ were detected in two patients. With regard to the long serum half-life/longer than surgery/ ceftriaxone is suitable for short-term prophylaxis in thoracic surgery. The serum level and ceftriaxone penetration into the pulmonary parenchyma is higher than the minimal inhibitory concentration in the majority of isolated bacteria.
Vyhnánek
F
F
Chirurgická klinika 3.LF UK, Praha.
Lochmann
O
O
Fanta
J
J
D001419:Bacteria / Q000302:isolation & purification; D001980:Bronchi / Q000382:microbiology; D002443:Ceftriaxone / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017558:Elective Surgical Procedures; D006801:Humans; D011292:Premedication; D013903:Thoracic Surgery; D014132:Trachea / Q000382:microbiology
D002443:Ceftriaxone
Krátkodobá profylaxe ceftriaxonem u plánovaných nitrohrudních operací.