Trisomy 5 in long-term cultures from bone marrow of patients with solid tumors.
Long-term cultures of bone marrow from 15 cases diagnosed previously with primary solid tumors were analyzed cytogenetically. Of these cases, 10 had normal karyotypes and five had chromosomal abnormalities. Trisomy 5 was found in four cases, three with trisomy 5 as the only change and one with trisomy 5 and trisomy 12. These results suggest that trisomy 5 may be a nonrandom change associated with an in vitro or in vivo phenomenon.
Ozisik
Y Y
YY
Cancer Center of Southwest Biomedical Research Institute and Genetrix, Inc., Scottsdale, Arizona 85251.
Morgan
R
R
Peier
A
A
Meloni
A M
AM
Sandberg
A A
AA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000737:chemistry; D002648:Child; D002675:Child, Preschool; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D014314:Trisomy / Q000235:genetics*; D014407:Tumor Cells, Cultured