Reduced urinary kallikrein excretion in human renovascular hypertension caused by nonspecific aortoarteritis and other disorders.
In this study urinary kallikrein excretion was measured using the kininogenase bioassay technique in 12 normal volunteers and 23 patients with angiographically-proven renovascular hypertension (RVHT). In 13 of these (group I), RVHT was due to nonspecific aortoarteritis (NSAA) and in 10 (group II) due to other causes. Urinary kallikrein (UKa) excretion was significantly lower in patients, with values still lower in NSAA. PRA was high in both the groups in comparison with controls; however, the levels were significantly lower in group I compared with group II. Finding of both UKa and PRA lower in group I is suggestive of long standing hypertension becoming volume dependent with nephrosclerotic changes in the kidney. These results point to decreased renal kallikrein-kinin system activity as a feature of NSAA that probably contributes chiefly to the maintenance of the hypertensive state. Normalisation of BP with restoration of UKa and PRA towards normal in three patients of group I and five in group II further support the role of UKa not only when over activity of renin-angiotensin system is responsible for RVHT as in group II but also in group I when the hypertension becomes volume dependent.
Dave
V
V
Department of Pharmacology, All-India Institute of Medical Sciences, New Delhi.
Lall
S B
SB
Dash
S C
SC
Seth
S D
SD
D000293:Adolescent; D000328:Adult; D001025:Aortitis / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000209:etiology / Q000652:urine*; D007610:Kallikreins / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood
D007610:Kallikreins; D012083:Renin