[The food-acquisition behavior of rats under conditions of the chronic activation and blockade of the neostriatal dopaminergic system].
Effects of three-week daily intrastriatal amphetamine (15 and 45 mcg) and haloperidol (5 mcg) microinjections were studied in rats in a Skinners's box. Enhancement of motor activity, stereotype movements, increase of rate of lever pressings were recorded at the background of amphetamine microinjections in a dose of 45 mcg. In animals with initially low level of conditioning dopaminergic striatal stimulation qualitatively changed behavioural strategy, which promoted the stable long-term activation of instrumental conditioning. Amphetamine in a dose of 15 mcg was ineffective. Haloperidol had the opposite effects, i. e., it impaired conditioned alimentary behaviour and induced parkinsonian-like akinetic status. The findings suggest an involvement of dopaminergic neostriatal system in conditioned food-procuring behavioural strategy.
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D000661:Amphetamine / Q000008:administration & dosage; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D006220:Haloperidol / Q000008:administration & dosage; D008297:Male; D008845:Microinjections; D017072:Neostriatum / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D012054:Reinforcement, Psychology; D013997:Time Factors
D011954:Receptors, Dopamine; D000661:Amphetamine; D006220:Haloperidol
Pishchedobyvatel'noe povedenie krys v usloviiakh khronicheskoĭ aktivatsii i blokady dofaminergicheskoĭ sistemy neostriatuma.