title: Acute stress stimulates secretion of GHRH and somatostatin into hypophysial portal blood of conscious sheep.
abstract: The effects of acute stress on growth hormone (GH) secretion and the mechanisms involved in its changes have been investigated in sheep. An acute isolation-restraint stress induced a rapid and significant increase in jugular GH levels in 12 out of 14 rams. GH-releasing hormone (GHRH) and somatostatin secretion during the same stress were studied in 5 animals prepared for hypophysial portal blood collection. A 3.5-fold increase in portal GHRH levels was observed concomitantly with a slight elevation in portal somatostatin. Portal corticotropin-releasing hormone (CRH) and jugular cortisol plasma levels increased during the same stress. Our data suggest that an isolation-restraint stress stimulates GH secretion in the sheep and that GHRH may be responsible for GH response.
authors: INSERUM U 297, Intitut Fédératif Jean Roche, Faculté de Médicine Nord, Marseille, France.
authors: M
authors: M
authors: Cataldi
authors: E
authors: E
authors: Magnan
authors: V
authors: V
authors: Guillaume
authors: A
authors: A
authors: Dutour
authors: N
authors: N
authors: Sauze
authors: L
authors: L
authors: Mazzocchi
authors: B
authors: B
authors: Conte-Devolx
authors: C
authors: C
authors: Oliver
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D013007:Growth Hormone-Releasing Hormone / Q000097:blood / Q000378:metabolism*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010902:Pituitary Gland / Q000098:blood supply / Q000378:metabolism*; D012149:Restraint, Physical; D012756:Sheep; D012934:Social Isolation; D013004:Somatostatin / Q000097:blood / Q000378:metabolism*; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D013004:Somatostatin; D003346:Corticotropin-Releasing Hormone; D013007:Growth Hormone-Releasing Hormone; D006854:Hydrocortisone