Nm23 protein expression in thyroid neoplasms.
The nm23 gene production has been heralded as a suppressor of metastasis in many human tumours but it is not clear at which stage in the metastatic process nm23 protein exerts its effect. The aim of this study was to test whether nm23 protein is associated with occurrence or category of angioinvasion. We have made use of the well documented fact that follicular carcinoma of the thyroid may show vascular invasion whereas papillary carcinomas may metastasis via the lymphatics. 65 thyroid tumours (20 follicular adenomas, 22 papillary carcinomas, 23 follicular carcinomas) were stained for nm23 protein using an immunopurified polyclonal antibody. Nm23 protein status showed no correlation with category of thyroid tumour. This is indirect evidence that nm23 does not suppress metastasis by influencing vascular invasion in this tumour type.
Royds
J A
JA
Department of Pathology, University of Sheffield Medical School, England.
Silcocks
P B
PB
Rees
R C
RC
Stephenson
T J
TJ
D018263:Adenocarcinoma, Follicular / Q000235:genetics* / Q000378:metabolism; D000236:Adenoma / Q000235:genetics* / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis*; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis*
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins