title: Immunoglobulin replacement in patients with chronic lymphocytic leukaemia: a comparison of two dose regimes.
abstract: Previous studies have shown that intravenous immunoglobulin (IVIg) therapy is useful prophylaxis against infection in patients with secondary hypogammaglobulinaemia due to a low-grade lymphoproliferative disease. This randomized double-blind study was undertaken to determine prospectively the dose regime required. 34 such patients received IVIg at either 500 or 250 mg/kg every 4 weeks for 1 year. There was no significant difference in the rates of serious infections between the two groups of patients, which were well matched for disease and laboratory parameters. The rates of infection seen were similar to those in IVIg groups of previous studies and strikingly different from those in the placebo group in the previously randomized placebo-controlled study.
authors: Department of Immunology, John Radcliffe Hospital, Oxford.
authors: H
authors: H
authors: Chapel
authors: M
authors: M
authors: Dicato
authors: H
authors: H
authors: Gamm
authors: V
authors: V
authors: Brennan
authors: F
authors: F
authors: Ries
authors: C
authors: C
authors: Bunch
authors: M
authors: M
authors: Lee
mesh_terms: D000368:Aged; D016638:Critical Illness; D004306:Dose-Response Relationship, Immunologic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G