title: Leuprolide acetate depot for the treatment of uterine leiomyomas. Changes in bone density, uterine volume and uterine vascular resistive index.
abstract: This study measured the changes in uterine volume, uterine vascular resistive index and lumbar vertebral bone density before and after a six-month course of leuprolide acetate depot in women with uterine leiomyomas. All nine patients studied were black. The high baseline bone density of black women may provide a greater scope for the use of gonadotropin agonists as compared to women in the general population. A significant reduction in uterine volume was achieved in the patients with leuprolide therapy. Uterine vascular resistive indices were not altered consistently following leuprolide therapy in women with leiomyomas.
authors: Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson.
authors: M E
authors: ME
authors: Rivlin
authors: R B
authors: RB
authors: Patel
authors: L W
authors: LW
authors: Hess
authors: D B
authors: DB
authors: Hess
authors: G R
authors: GR
authors: Meeks
mesh_terms: D000328:Adult; D044383:Black People; D015519:Bone Density / Q000187:drug effects*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D016729:Leuprolide / Q000494:pharmacology / Q000627:therapeutic use*; D009929:Organ Size / Q000187:drug effects; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D003692:Delayed-Action Preparations; D016729:Leuprolide