[Long-term antihypertensive effect of delayed-action molsidomine].
The long-term antihypertensive efficacy of molsidomine 8 mg bid was studied in 24 patients with coronary artery disease in a double-blind, placebo-controlled trial of 3 weeks duration. Ambulatory 24-h blood pressure measurements were performed at days 1, 2, 7, 14, and 21. Sphygmomanometric measurements of blood pressure heart rate and a protocol for number and time of angina pectoris attacks were also taken. Following the application of molsidomine a reduction of mean 24-h systolic blood pressure of 14% and of mean diastolic blood pressure of 11% was observed. The duration of the blood-pressure-lowering action was 7 h. After 3 weeks of treatment with 8 mg molsidomine sr bid a persistent and significant reduction of systolic and diastolic blood pressure was found. A similar acute and long-term effect was found by manually measured blood pressures. Heart rate was unchanged under molsidomine while the frequency of angina pectoris was diminished. In conclusion, a long-lasting antihypertensive efficacy (without signs of tolerance) was found over a 3-week period of treatment with 8 mg molsidomine in a slow-release formulation given twice a day.
Fach
W A
WA
Klinik Nordrhein mit Abteilung Rhein-Ruhr.
Kostanecka
T
T
Kober
G
G
D001794:Blood Pressure / Q000187:drug effects; D015924:Blood Pressure Monitors; D003327:Coronary Disease / Q000188:drug therapy; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D008981:Molsidomine / Q000008:administration & dosage* / Q000009:adverse effects
D003692:Delayed-Action Preparations; D008981:Molsidomine
Antihypertensive Langzeitwirkung von retardiertem Molsidomin.