title: The preventive role of chemical sympathectomy on contralateral testicular hypoxic parameters encountered during unilateral testicular torsion.
abstract: OBJECTIVE
  To evaluate the effect of chemical sympathectomy on lactic acid and hypoxanthine concentrations in both testes during unilateral testicular torsion in a rat experimental model.
  
  
  METHODS
  Four groups, comprising 10 rats each, were studied. Group I was the control group, Group II rats received a placebo and underwent unilateral testicular torsion, Groups III and IV received guanethidine monosulphate and 6-OH-dopamine hydrobromide respectively, and underwent unilateral testicular torsion. The levels of lactic acid and hypoxanthine in both testes were measured.
  
  
  RESULTS
  In rats in Group II the levels of lactic acid and hypoxanthine in both testes were significantly elevated when compared to the control group. In the groups of rats that had undergone chemical sympathectomy, the levels of lactic acid and hypoxanthine were significantly decreased in the contralateral testes compared to rats in Groups I and II.
  
  
  CONCLUSIONS
  Chemical sympathectomy prevents the elevation of lactic acid and hypoxanthine levels in the contralateral testis of rats with unilateral testicular torsion. Therefore, we conclude that contralateral testicular damage during unilateral testicular torsion may result through a reflex activating sympathetic system.
authors: Department of Paediatric Surgery, Hacettepe University, School of Medicine, Ankara, Türkiye.
authors: G
authors: G
authors: Karagüzel
authors: F C
authors: FC
authors: Tanyel
authors: K
authors: K
authors: Kilinç
authors: N
authors: N
authors: Büyükpamukçu
authors: A
authors: A
authors: Hiçsönmez
mesh_terms: D000818:Animals; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D008297:Male; D011817:Rabbits; D013086:Spermatic Cord Torsion / Q000378:metabolism*; D013563:Sympathectomy, Chemical; D013737:Testis / Q000737:chemistry* / Q000601:surgery
chemical_list: D007042:Hypoxanthines; D007773:Lactates; D019271:Hypoxanthine; D019344:Lactic Acid