title: An association between successful vaccination against the bovine nodular worm, Oesophagostomum radiatum and induction of eosinophilia.
abstract: Immunization of 48 cattle with somatic antigen extracts of the nodular worm, Oesophagostomum radiatum, reduced faecal egg counts (FEC) by 51% and worm burden by 47%. The antibody titre of each animal was correlated to both worm burden (r = -0.40, P < 0.005) and FEC (r = -0.37, P < 0.01). The vaccinated cattle showed wide variation in their response to vaccination with worm burdens after challenge infection varying from 0 to 4060. Of these 48 vaccinated animals, eight developed sterile immunity (worm burden = 0, FEC = 0) whereas a further 10 had no protective response to immunization (worm burden > 1,000, FEC > 100). A comparison of these two sub-groups showed that the group with sterile immunity had a higher antibody titre (P < 0.05). In addition, the group with sterile immunity developed a blood eosinophilia between 21 and 29 days after challenge infection. Vaccinated, unprotected calves and control, unvaccinated calves did not develop eosinophilia.
authors: CSIRO Division of Tropical Animal Production, Long Pocket Laboratories, Indooroopilly, Queensland, Australia.
authors: I J
authors: IJ
authors: East
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D004802:Eosinophilia / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D008297:Male; D009814:Oesophagostomiasis / Q000150:complications / Q000276:immunology / Q000469:parasitology / Q000628:therapy / Q000662:veterinary*; D009815:Oesophagostomum / Q000276:immunology* / Q000302:isolation & purification; D010270:Parasite Egg Count / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000947:Antigens, Helminth