title: Identification and characterization of a cDNA encoding ribosomal protein S12 from Xenopus laevis.
abstract: The complete nucleotide (nt) sequence of the cDNA clone XL-S12, encoding a Xenopus laevis (Xl) homologue of the mammalian ribosomal protein S12, has been determined. The sequence predicts a Xl S12 protein of 132 amino acids (aa) with a molecular mass of 14.7 kDa. Xl S12 shares 95 and 97% aa sequence identity with the human and murine S12 proteins, respectively. Analysis of nt substitution patterns and rates indicates that S12 is a very highly constrained protein, evolving at an estimated rate of only 0.03 x 10(-9) non-synonymous (protein-altering) substitutions per site per year.
authors: Department of Genetics, Trinity College, Dublin, Ireland.
authors: L T
authors: LT
authors: Seery
authors: D R
authors: DR
authors: Schoenberg
authors: M E
authors: ME
authors: Canning
authors: A S
authors: AS
authors: Whitehead
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D018076:DNA, Complementary / Q000032:analysis* / Q000737:chemistry; D015186:Hominidae / Q000235:genetics; D006801:Humans; D008322:Mammals; D051379:Mice / Q000235:genetics; D008969:Molecular Sequence Data; D051381:Rats / Q000235:genetics; D012269:Ribosomal Proteins / Q000096:biosynthesis / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014982:Xenopus laevis / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D012269:Ribosomal Proteins; C034212:ribosomal protein S12