title: Genetic analysis of IgE and the IGHE, IGHEP1 and IGHEP2 genes in atopic families.
abstract: The familial occurrence of allergic diseases was studied in 478 individuals and their family members. The results showed that there was pronounced familial clustering. Total serum IgE concentrations of atopic patients and their parents were well correlated. Moreover, the concentration of specific IgE of the patients and their parents was also well correlated, suggesting that IgE production was genetically determined. To determine if major structural abnormalities of IGHE, IGHEP1 and IGHEP2 genes might lead to aberrant control and subsequent increase in IgE concentration, genomic DNAs from 55 individuals, i.e., 31 atopic patients and their family members, were examined. We detected the IGHE, IGHEP1 and IGHEP2 genes in all 55 leukocyte DNAs. We could not find any large deletions or duplications in the IGHE, IGHEP1 and IGHEP2 genes of atopic patients with high serum IgE concentrations.
authors: Department of Pediatrics, Gifu University, School of Medicine, Japan.
authors: H
authors: H
authors: Fujii
authors: N
authors: N
authors: Kondo
authors: H
authors: H
authors: Agata
authors: O
authors: O
authors: Fukutomi
authors: S
authors: S
authors: Shinoda
authors: N
authors: N
authors: Kuwabara
authors: S
authors: S
authors: Tomatsu
authors: T
authors: T
authors: Kondo
authors: R
authors: R
authors: Inoue
authors: T
authors: T
authors: Orii
mesh_terms: D000293:Adolescent; D015139:Blotting, Southern; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D003876:Dermatitis, Atopic / Q000235:genetics*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000235:genetics*; D007223:Infant; D007962:Leukocytes / Q000378:metabolism; D010375:Pedigree
chemical_list: D015342:DNA Probes; D007073:Immunoglobulin E; D004247:DNA