title: [Effects of selenium on endogenous synthesis of N-nitrosamines and toxicity of nitrites in rats].
abstract: Male Wistar rats were fed selenium (0.2, 2.9 or 5.5 mg/kg of dry feed) in the form of selenomethionine. They also received for 6 weeks amidopyrine (33 mg/kg b.w.) and/or sodium nitrite (20 mg/kg b.w.) administered intragastrically. The quantitation of endogenously synthetized volatile nitrosamines in the stomach, selenium in the serum, biochemically evaluated nitrite and nitrosamines toxicity revealed an inverse relationship between feed selenium concentrations and the amount of endogenously produced nitrosodimethylamine from equal precursor doses. A protective selenium effect on methemoglobin-producing action of nitrite ions was established. It is shown that introduction of precursors induces increased body need in selenium.
authors: E M
authors: EM
authors: Mamaeva
authors: G F
authors: GF
authors: Zhukova
authors: S G
authors: SG
authors: Vlaskina
authors: V P
authors: VP
authors: Deriagina
authors: N A
authors: NA
authors: Golubkina
authors: A B
authors: AB
authors: Sokolov
authors: S A
authors: SA
authors: Khotimchenko
mesh_terms: D000632:Aminopyrine / Q000008:administration & dosage; D000821:Animal Feed; D000818:Animals; D001669:Biochemical Phenomena; D001671:Biochemistry; D004128:Dimethylnitrosamine / Q000378:metabolism; D008297:Male; D009573:Nitrites / Q000633:toxicity*; D009602:Nitrosamines / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D012645:Selenomethionine / Q000008:administration & dosage / Q000494:pharmacology; D012977:Sodium Nitrite / Q000008:administration & dosage
chemical_list: D009573:Nitrites; D009602:Nitrosamines; D000632:Aminopyrine; D012645:Selenomethionine; D012643:Selenium; D012977:Sodium Nitrite; D004128:Dimethylnitrosamine
vernacular_title: Vliianie selena na éndogennyĭ sintez N-nitrozaminov i toksicheskoe deĭstvienitritov u krys.