[The carcinogen urethane induces high-amplitudes circaseptan variations in target tissues and disrupts the rhythm of cell count in lymphoid organs].
The presence of tumor is accompanied by biological rhythms disturbance both in damaged (target) organ, and in nondamaged systems. As discoordination of biorhythms is sometimes one of the causes of pathologic states, we have investigated, which changes in system of about 7-day duration (circaseptan) biorhythms preceded the tumor appearance. The model of lung carcinogenesis, induced by single dose (0.25 mg/g of body weight) of carcinogen urethan in A mice, was used. Characteristics of both target organ, and other organs was studied at the stage, preceding the tumor appearance. The data obtained were compared with the analogous characteristics of the control group, once injected with noncarcinogenic analog of urethan, methylcarbamate. The presence of about 7-day rhythms in several organs, nonsensitive to carcinogenic action of urethan, was demonstrated in the control group. The periods of oscillations were: in bone marrow (the number of nuclear cells)--5.2 days; in thymus (mass; the number of nuclear cells)--7.8, 8.2 days; in liver (mass)--6.2 days; in kidney) mass)--8.9 days; in blood (the number of leukocytes)--10.6 and 4.0 days, ect. In the control lungs low-amplitude rhythm of tissue mechanical characteristics (T = 3.5 days), was revealed (these characteristics indicate the extent to which cells are integrated into tissue). Single carcinogen injection resulted in statistically significant decrease (1.4-1.8 fold) of the periods of the main garmonic in the resistant organs. In lungs (target organ) powerful high-amplitude circaseptan oscillations, not inherent to the lungs of control mice, arise in this tissue after the carcinogen injection.(ABSTRACT TRUNCATED AT 250 WORDS)
Riabykh
T P
TP
Modianova
E A
EA
Kasatkina
N N
NN
Bodrova
N B
NB
D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001773:Blood Cells; D002940:Circadian Rhythm / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size; D014520:Urethane / Q000633:toxicity*
D014520:Urethane
Kantserogen uretan indutsiruet vysokoamplitudnye tsirkaseptannye kolebaniia v tkani-misheni i narushaet ritmiku chislennosti kletok v limfoidnykh organakh.