Reducing the incidence of coronary heart disease by managing hypertension: implications of syndrome X.
Syndrome X is a constellation of abnormalities; it appears to be strongly linked to insulin resistance and the risk of atherosclerosis. It consists of hypertension, glucose intolerance, obesity, dyslipidemia and, observed more recently, coagulation abnormalities. It is possible that treating blood pressure levels alone while ignoring or worsening other strongly associated risk factors has resulted in minimal effects on the incidence of coronary heart disease (CHD). Syndrome X has raised the awareness of these associated risk factors and has further led to the consideration of hypertension as a metabolic disease. The epidemiologic evidence in support of the link between insulin resistance and hypertension is reviewed, and the public health implications of these data are outlined.
Reddy
S S
SS
Dalhousie University Halifax, NS.
D003327:Coronary Disease / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000517:prevention & control*; D015994:Incidence; D007333:Insulin Resistance; D017566:Microvascular Angina / Q000150:complications* / Q000517:prevention & control*; D011634:Public Health; D012307:Risk Factors