Parvalbumin expression reveals a vibrissa-related pattern in rabbit SI cortex.
The expression of parvalbumin-like immunoreactivity (PV-LIR) was examined in the mystacial representation within the primary somatosensory cortex (SI) of postnatal day 21 and adult rabbits. PV-LIR was expressed in a prominent vibrissa-like array of patches in layer IV despite the fact that barrels were indistinct in the cytoarchitecture. Each patch consisted of dense terminal-like PV-LIR and a preferential concentration of intensely labeled stellate neurons. Layer V contained scattered small and large intensely labeled basket cells. Layer Vb had a distinct layer of lightly labeled large pyramidal cells that received labeled basket cell terminations. Upper layer VI also contained patches of terminal-like PV-LIR that were in register with the overlying vibrissae pattern. These patches also contained a preferential distribution of labeled non-pyramidal cells as well as modified pyramidal cells. These results suggest that PV-LIR in rabbits delineates cortical modules composed of thalamocortical afferents and inhibitory local circuits in the absence of a distinct barrel cytoarchitecture. In contrast, prior studies of rat SI cortex have revealed a distinct barrel cytoarchitecture but a uniform distribution of PV-LIR. The differences in PV-LIR between rodents and lagomorphs within the vibrissae representation in SI may be related to species differences in thalamic and local cortical circuits devoted to the whisker sense.
McMullen
N T
NT
Department of Cell Biology and Anatomy, University of Arizona College of Medicine Tucson 85724.
Smelser
C B
CB
Rice
F L
FL
D000375:Aging / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping; D007150:Immunohistochemistry; D008751:Methylene Blue; D009411:Nerve Endings / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010320:Parvalbumins / Q000032:analysis / Q000096:biosynthesis*; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology; D011817:Rabbits; D013003:Somatosensory Cortex / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation*
D010320:Parvalbumins; D008751:Methylene Blue