title: Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part I: Brain glucose metabolism is increased after GABAA receptors activation.
abstract: Though gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the human central nervous system, the metabolic response to GABA system activation remains imperfectly known. We studied in vivo with positron emission tomography (PET) the variations of glucose metabolism in the human brain after stimulation of the GABAA receptors by systemic administration of the specific GABAA agonist, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP). These investigations were performed in three normal volunteers and as part of presurgical evaluation for temporal lobe epilepsy in six patients. While clinical and electroencephalographic (EEG) monitoring showed a sedative effect and sleepiness after THIP administration, glucose metabolism was paradoxically increased in grey matter structures, which are known to have a high density of GABAA receptors. These findings suggest that the pharmacological activation of GABA pathways, although inhibitory and producing a decrease of vigilance, increases the energetic demand at least during a phase of GABA agonist action, probably at the synaptic or at the glial cell level.
authors: Centre d'Exploration et de Recherches Médicales par Emission de Positons, Lyon, France.
authors: R
authors: R
authors: Peyron
authors: D
authors: D
authors: Le Bars
authors: L
authors: L
authors: Cinotti
authors: L
authors: L
authors: Garcia-Larrea
authors: G
authors: G
authors: Galy
authors: P
authors: P
authors: Landais
authors: P
authors: P
authors: Millet
authors: F
authors: F
authors: Lavenne
authors: J C
authors: JC
authors: Froment
authors: P
authors: P
authors: Krogsgaard-Larsen
mesh_terms: D000328:Adult; D001519:Behavior / Q000187:drug effects; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005462:Fluorine Radioisotopes; D018755:GABA Agonists / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011869:Radioligand Assay; D011963:Receptors, GABA-A / Q000187:drug effects*; D012016:Reference Values; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D018755:GABA Agonists; D007555:Isoxazoles; D011963:Receptors, GABA-A; D005947:Glucose; C015542:gaboxadol