Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania.
In an open clomipramine dose finding study, 33 depressed indigenous African outpatients were randomly assigned to two regimens of treatment with 125 mg and 75 mg oral medications daily. At the end of eight weeks of treatment, 16 patients (48.5 pc) were on the 75 mg regime, and 17 (54.8 pc) were on 125 mg. Analysis of depression scores on the Beck-Rafaelsen scale indicated improvements of depression in both regimes of equal magnitude. Analysis of variance showed no statistically significant difference on dose response between the two regimes. The higher doses, however, were associated with more drowsiness and tremulousness. It is suggested that Black African patients respond to tricyclic antidepressants in much lower doses than those recommended in Western textbooks. It is also apparent that side effects of tricyclic antidepressants, which have been implicated in non-compliance to medication, could be avoided without compromising treatment outcome.
Kilonzo
G P
GP
Department of Psychiatry, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.
Kaaya
S F
SF
Rweikiza
J K
JK
Kassam
M
M
Moshi
G
G
D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D044383:Black People; D002997:Clomipramine / Q000008:administration & dosage*; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010045:Outpatients; D012720:Severity of Illness Index; D013636:Tanzania; D016896:Treatment Outcome
D002997:Clomipramine