[Post-transfusion purpura].
Post-transfusion purpura (PTP) is a rare syndrome that may develop a week after blood transfusion. In this syndrome, which occurs mainly in women, blood transfusion is followed by severe thrombocytopenia a week later. A 72-year-old woman with this syndrome is presented. High-dose intravenous gamma-globulin resulted in prompt resolution of her thrombocytopenia. The basic pathophysiologic mechanism of PTP is the development of an alloantibody to a human platelet antigen. The mystery of PTP is why the patients' own, as well as transfused PLA1-negative platelets, are destroyed.
Weiner
P
P
Medical Dept. A, Hillel Yaffe Medical Center, Hadera.
Ganem
R
R
Schechter
Y
Y
D000368:Aged; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D011696:Purpura, Thrombocytopenic / Q000209:etiology* / Q000628:therapy; D065227:Transfusion Reaction
D016756:Immunoglobulins, Intravenous