Assessment of MRI criteria for MS in Japanese MS and HAM/TSP.
We evaluated the usefulness of the MRI criteria for multiple sclerosis (MS) proposed by Paty et al and Fazekas et al in 36 Japanese MS patients, using HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) as the control. Although 30 of 36 HAM/TSP patients had multiple white matter lesions on T2-weighted cranial MRI, only two fulfilled the MRI criteria for MS. At the same time, 31 of the 36 MS patients fulfilled the primary MRI criterion, yielding 93% specificity and 86% sensitivity for the criterion. MS has disease-specific MRI abnormalities.
Kuroda
Y
Y
Department of Internal Medicine (Division of Neurology), Saga Medical School, Japan.
Matsui
M
M
Yukitake
M
M
Kurohara
K
K
Takashima
H
H
Takashima
Y
Y
Endo
C
C
Kato
A
A
Mihara
F
F
D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000473:pathology*; D015493:Paraparesis, Tropical Spastic / Q000175:diagnosis* / Q000453:epidemiology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity