title: Cefetamet pivoxil in the treatment of uncomplicated gonorrhea.
abstract: We studied the efficacy and safety of cefetamet pivoxil (CAT), an oral aminothiazolyl cephalosporin, in a series of open, comparative multicenter studies in 207 women (four study centers) with uncomplicated gonorrhea, and summarized and pooled the results with those of earlier open dose-finding trials (360 men; six study centers). We compared single-dose treatment regimen of CAT--over the range of 400-1500 mg--with spectinomycin, thiamphenicol, ampicillin, or amoxicillin plus probenecid. The overall cure rates were 100% in 88 women treated with 1500 mg CAT and in 137 men treated with 1200 or 1500 mg CAT, 98% (114 of 116 men) in those treated with 800 or 1000 mg CAT, and 93% (42 of 45 men) in those treated with 400 or 500 mg CAT; the composite cure rate of the comparators was 97%. The tolerability of CAT (n = 428) compared favorably (1.8% adverse events) with that of the standard drugs (n = 139) (4.3% adverse events). Single-dose treatment with 1500 mg CAT is effective and safe in adults with uncomplicated gonorrhea.
authors: Public Institution-Urology, Clinical Urogynecologists Association, Rio de Janeiro, Brazil.
authors: R
authors: R
authors: Lucena
authors: C E
authors: CE
authors: Borges
authors: L F
authors: LF
authors: Vieiralves
authors: J M
authors: JM
authors: Kanga
authors: P
authors: P
authors: Hohl
authors: M
authors: M
authors: Zappelini
authors: M
authors: M
authors: Kissling
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015296:Ceftizoxime / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: C047444:cefetamet; D015296:Ceftizoxime