The brain beyond the synapse: a review.
Several topics in contemporary neuroscience are treated in historical perspective. These include the localizationist-connectionist model of brain function and its influence on experimental neuroscience and clinical management of brain damaged persons; brain plasticity; the accumulating evidence for non-synaptic diffusion neurotransmission (NDN) as a major mechanism of information transmission in the brain; and the co-existence of plasticity and localization as well as of synaptic and non-synaptic mechanisms. The status of theory in the neurosciences is examined.
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Department of Rehabilitation Medicine, University of Wisconsin, Madison 53706.
D000818:Animals; D001921:Brain / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure