title: [Formation of a neofascia after implantation of a composite patch in the inguinal region].
abstract: In this study, a novel patch material composed of polyglactin 910 and polydioxanon was tested in animal experiments for its use in the surgical repair of hernias. The material was implanted laparoscopically into the inner inguinal region of three hybrid running-pigs. No postoperative complications were observed. The animals were killed 14 and 48 days after surgery. Both the macroscopic and microscopic examination showed a de novo formation of connective tissue at the site of implantation, which may be regarded as a new fascia. Due to the cooperation of fibroblasts and free cells of the connective tissue, new intercellular matrix was formed after the resorption of the implanted material. A model of this cell cooperation is outlined in the study. The technical advantages of the implantation material are demonstrated and its benefits for minimally invasive surgery emphasized. Because of its special properties, the material may be recommended for later clinical traits in the surgery of fascia.
authors: Abteilung für Allgemeinchirurgie, Chirurgische Universitätsklinik und Poliklinik Hamburg.
authors: C
authors: C
authors: Seiler
authors: J
authors: J
authors: Brenner
authors: W
authors: W
authors: Lierse
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D005205:Fascia / Q000473:pathology*; D006552:Hernia, Inguinal / Q000473:pathology / Q000601:surgery*; D007264:Inguinal Canal / Q000473:pathology / Q000601:surgery; D010535:Laparoscopy; D008297:Male; D016687:Polydioxanone; D011098:Polyglactin 910; D019736:Prostheses and Implants; D012038:Regeneration / Q000502:physiology; D013552:Swine; D014945:Wound Healing / Q000502:physiology*
chemical_list: D016687:Polydioxanone; D011098:Polyglactin 910
vernacular_title: Bildung einer Neofaszie nach Implantation eines Composite-Vlieses in der Leistenregion.