[Paraneoplastic edema syndromes in acute myelomonocytic leukemia: role of TNF-alpha and IL-6?].
We report the case of a 56 year-old man in remission of a Hodgkin's disease who had an acute myelomonocytic leukemia with major edemas. Chemotherapy temporarily allowed a concomitant regression of edemas, hyperleukocytosis and tumor necrosis factor and interleukin-6 levels which were initially elevated. We discuss the role of these two cytokines in endothelium permeability disorders.
Sotto
A
A
Service de médecine interne B, hôpital Carémeau, CHU, Nîmes, France.
Richard
B
B
Assens
C
C
Porneuf
M
M
Bes
G
G
Jourdan
J
J
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects / Q000502:physiology; D004487:Edema / Q000503:physiopathology*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis / Q000494:pharmacology / Q000502:physiology*; D015479:Leukemia, Myelomonocytic, Acute / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000503:physiopathology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000494:pharmacology / Q000502:physiology*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
Syndrome oedémateux paranéoplasique au cours d'une leucémie aiguë myélomonocytaire: rôle du TNF alpha et de l'IL-6?