Integration of antimicrobial host defenses: role of the bactericidal/permeability-increasing protein.
Our understanding of the complex and integrated host-defense systems against microbial infection has progressed rapidly with the characterization of individual components. However, the various factors must be studied not only in isolation, but also in a closer approximation to the in vivo situation, where these factors interact. This is well illustrated in recent studies of the role of the bactericidal/permeability-increasing protein.
Elsbach
P
P
Dept of Medicine, New York University School of Medicine, NY 10016.
Weiss
J
J
Levy
O
O
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000276:immunology; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D005798:Genes, Bacterial; D007249:Inflammation / Q000503:physiopathology; D007963:Leukocytes, Mononuclear / Q000737:chemistry* / Q000276:immunology; D008322:Mammals; D008565:Membrane Proteins; D008854:Microscopy, Electron; D010740:Phospholipases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D008565:Membrane Proteins; C021623:bactericidal permeability increasing protein; D010740:Phospholipases