Antroduodenal manometry in children and adults with severe non-ulcer dyspepsia.
BACKGROUND
Nonulcer dyspepsia is common in adults but has been recognized only recently in children.


METHODS
We compared signs, symptoms, and antroduodenal motility findings in 34 children and 35 adults with severe nonulcer dyspepsia.


RESULTS
Symptoms and signs were similar in the two groups. Ten children (29%) and one adult (3%) required tube feedings (p = 0.01). Abdominal surgery had been performed on 6 of 34 (18%) children and 18 of 35 adults (51%) (p < 0.01), without relief of symptoms. Esophageal manometry was abnormal in 5 of 23 (22%) children and 6 of 31 (19%) adults. Antroduodenal manometry was suggestive of neuropathy in 25 children and 26 adults and of myopathy in 3 children and 2 adults. Absence of phase 3 of the migrating motor complex was found in 4 children and 17 adults (p = 0.01). Antroduodenal manometry was normal in six children and seven adults.


CONCLUSIONS
Signs, symptoms, and discrete manometric abnormalities of childhood nonulcer dyspepsia resembled those of adult nonulcer dyspepsia. Manometric findings in nonulcer dyspepsia resembled those reported in chronic intestinal pseudo-obstruction, suggesting that these conditions are on a continuum of enteric neuromuscular diseases.
Di Lorenzo
C
C
Dept. of Pediatrics, Harbor-UCLA Medical Center.
Hyman
P E
PE
Flores
A F
AF
Kashyap
P
P
Tomomasa
T
T
Lo
S
S
Snape
W J
WJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004386:Duodenum / Q000503:physiopathology*; D004415:Dyspepsia / Q000503:physiopathology*; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating; D011706:Pyloric Antrum / Q000503:physiopathology*