[Growth factors: from oocyte maturation to blastocyst].
Developmental arrests and losses of viability are observed in vitro, when embryos are cultured. A harmonious oocyte maturation is essential to obtain a balanced development. Factors that control this maturation are still unknown but growth factors seem to be involved: they are present in ovary and some of them (EGF, TGF-alpha, TGF-beta, PDGF) improve in vitro maturation. These factors are also involved in preimplantation development, either in an autocrine way (ligand and receptor genes expression in the embryo) or in a paracrine way (receptor gene expression in the embryo and ligand gene expression in the tractus). However, the precise role of each one and their interrelations are still speculative.
Croteau
S
S
Laboratoire de biologie appliquée, INSA-Bât. 406, Villeurbanne.
Menezo
Y
Y
D001755:Blastocyst / Q000502:physiology*; D005307:Fertilization in Vitro; D015870:Gene Expression; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D009865:Oocytes / Q000254:growth & development* / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000502:physiology
D006133:Growth Substances; D017978:Receptors, Growth Factor
Les facteurs de croissance: de la maturation ovocytaire au blastocyste.