The presence of tumour necrosis factor in CSF and plasma after severe head injury.
In a cohort of victims of traumatic brain injury, 18 out of 50 patients had a plasma tumour necrosis factor (TNF) concentration above 2 pg/ml within 24 h of injury (mean 12.19, SD 45.96 pg/ml). Twenty-six had CSF samples available of which 17 demonstrated TNF concentrations above 1 pg/ml (mean 3.98, SD 3.61 pg/ml). We conclude that traumatized brain parenchyma is a significant source of TNF activity and implicate the cytokine in cellular metabolic derangements following head injury.
Ross
S A
SA
Queen's University of Belfast, Department of Surgery, Northern Ireland.
Halliday
M I
MI
Campbell
G C
GC
Byrnes
D P
DP
Rowlands
B J
BJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier / Q000502:physiology; D001925:Brain Damage, Chronic / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000601:surgery; D001929:Brain Edema / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000601:surgery; D001930:Brain Injuries / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid*
D014409:Tumor Necrosis Factor-alpha