Cystic fibrosis in children from ethnic minorities in the West Midlands.
BACKGROUND
We have observed that Doctors often perceive that cystic fibrosis (CF) is exceptionally rare in non-whites, and that this bias has repeatedly resulted in diagnostic delay. We therefore compared the age at diagnosis, genetic features and relative prevalence of CF in non-whites and white patients in the West Midlands.


METHODS
Analysis of data on all CF patients diagnosed in childhood and stored in the West Midlands CF register.


RESULTS
Sixteen of the 514 children on the register were not of white European extraction, comprising 13 patients whose families originated from the Indian subcontinent, two of mixed AfroCaribbean/white European extraction and one of mixed Pakistani/white European extraction. The median age of diagnosis was similar in the white European and non-white patients (0.42 vs. 0.33 years, 95% CI for the difference of the medians -0.15, 0.37). However, in five cases with typical clinical features the diagnosis appears to have been delayed because of the child's racial origin (median age of diagnosis 3.87 years), and in five others the diagnosis was obvious (two siblings with CF, three had meconium ileus). There was a degree of consanguinity in nine cases. Five patients were homozygous or heterozygous for the delta F508 mutation, but no mutation could be identified in the remaining 11 patients.


CONCLUSIONS
The possibility of CF needs to be considered in any patient with relevant clinical problems, regardless of racial origin. These findings need to be considered when planning any mass population screening programme for CF.
Spencer
D A
DA
Cystic Fibrosis Unit, Birmingham Children's Hospital, U.K.
Venkataraman
M
M
Higgins
S
S
Stevenson
K
K
Weller
P H
PH
D001459:Bangladesh / Q000208:ethnology; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D004739:England / Q000453:epidemiology; D005006:Ethnicity; D006801:Humans; D007194:India / Q000208:ethnology; D007223:Infant; D009154:Mutation; D010154:Pakistan / Q000208:ethnology; D015995:Prevalence; D013997:Time Factors