3q aberration and monosomy 7 in ANLL presenting with high platelet count and diabetes insipidus.
Diabetes insipidus and thrombocytosis were presenting symptoms in a case of adult ANLL-M1. Cytogenetic investigations revealed a typical 3q rearrangement, i.e. inv(3)(q21q26). A subclone with monosomy 7 was also found and documented by FISH analysis. Correlations between clinical/hematological features and cytogenetic/FISH results are discussed.
La Starza
R
R
Ematologia ed Immunologia Clinica, Università degli Studi di Perugia, Italy.
Falzetti
D
D
Fania
C
C
Tabilio
A
A
Martelli
M F
MF
Mecucci
C
C
D002869:Chromosome Aberrations; D002893:Chromosomes, Human, Pair 3; D003919:Diabetes Insipidus / Q000097:blood / Q000150:complications / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D010976:Platelet Count