Concentration dependence of adenosine and the protection of rat cortical neurones during anoxia.
Aglycaemic/anoxic slices of rat olfactory cortex lose all electrical activity. On reoxygenation, 10 microM adenosine enhanced recovery from 23 +/- 7% to 53 +/- 12%; an increased tissue endurance of 5-7 min. 100 microM adenosine slightly depressed recovery to 11.5 +/- 2.1%. Dipyridamole increased whereas adenosine deaminase reduced recovery. These observations question the therapeutic effectiveness of high adenosine concentrations.
Donaghy
K M
KM
School of Biomedical Science, Queen's University, Belfast, UK.
Scholfield
C N
CN
D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000243:Adenosine Deaminase / Q000494:pharmacology; D000818:Animals; D004176:Dipyridamole / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D000860:Hypoxia / Q000473:pathology* / Q000503:physiopathology; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009833:Olfactory Pathways / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D004176:Dipyridamole; D000243:Adenosine Deaminase; D000241:Adenosine