Postmortem distribution of mexiletine in a fatal overdose.
A case involving a fatal overdose of mexiletine is presented. Quantitation of the drug was accomplished by gas chromatography with a flame-ionization detector. The presence of mexiletine was confirmed by gas chromatography-mass spectrometry. Toxicological analysis revealed the following tissue distribution of mexiletine: heart blood, 44.8 micrograms/mL; femoral blood, 10.0 micrograms/mL; vitreous, 8.6 micrograms/mL; liver, 171.6 micrograms/g; brain, 84.0 micrograms/g; and gastric contents, 1464 mg.
Rohrig
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Office of the Chief Medical Examiner, Oklahoma City, Oklahoma.
Harty
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D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D014018:Tissue Distribution
D008801:Mexiletine