Interleukin-6 production by macrophages from BALB/c mice with a chronic infection of lactic dehydrogenase virus.
The production of interleukin-6 (IL-6), which is known as a B cell differentiation factor, by peritoneal macrophages from mice with a chronic lactic dehydrogenase virus (LDV) infection was compared with that from uninfected mice. The same amounts of IL-6 were detected in the culture supernatant of macrophages from LDV-infected mice as those from uninfected mice. Furthermore IL-6 production of macrophages from LDV-infected and uninfected mice was not affected by the addition of indomethacin. These results suggested that many immunological alterations seen in LDV-infected mice may not be due to, at least in part, altered IL-6 production ability of macrophages and the IL-6 production may not be affected by cyclooxygenase-derived products.
Iwata
H
H
Laboratory of Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, Japan.
Hayashi
T
T
D000818:Animals; D018174:Arterivirus Infections / Q000378:metabolism*; D002908:Chronic Disease; D015850:Interleukin-6 / Q000096:biosynthesis*; D007772:Lactate dehydrogenase-elevating virus; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C
D015850:Interleukin-6