Gonadotrophin-independent precocious puberty and dyschondrosteosis.
We present a case of gonadotrophin-independent precocious puberty, as seen in McCune-Albright syndrome, and Leri-Weill dyschondrosteosis in a six and a half year-old girl. Her father also reports having early puberty and is similarly affected with dyschondrosteosis. This combination of features has not been reported previously, and represents the association of a skeletal dysplasia with an endocrinopathy.
Patel
L
L
Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, UK.
Clayton
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PE
Super
M
M
Price
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DA
D001848:Bone Diseases, Developmental / Q000150:complications* / Q000175:diagnosis; D002648:Child; D017373:Cyproterone Acetate / Q000627:therapeutic use; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic; D006801:Humans; D011629:Puberty, Precocious / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D017373:Cyproterone Acetate