title: The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease.
abstract: Approximately one-fourth of neuropathologically confirmed cases of Alzheimer's disease (AD) also have brainstem and neocortical Lewy bodies, constituting a Lewy body variant of AD. Because Lewy bodies are a pathologic hallmark of Parkinson's disease (PD), this subpopulation of AD subjects may have the same risk factors as PD subjects. Analyses of the cytochrome P450 CYP2D6-debrisoquine 4-hydroxylase mutant B allele, a susceptibility gene for PD, revealed a higher representation of this allele in the Lewy body variant of AD than in pure AD or non-AD without Lewy bodies.
authors: Department of Neurosciences, School of Medicine, UCSD, La Jolla 92093-0624.
authors: T
authors: T
authors: Saitoh
authors: Y
authors: Y
authors: Xia
authors: X
authors: X
authors: Chen
authors: E
authors: E
authors: Masliah
authors: D
authors: D
authors: Galasko
authors: C
authors: C
authors: Shults
authors: L J
authors: LJ
authors: Thal
authors: L A
authors: LA
authors: Hansen
authors: R
authors: R
authors: Katzman
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000473:pathology; D002871:Chromosome Banding; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D066298:In Vitro Techniques; D016631:Lewy Bodies / Q000473:pathology; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6