title: High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases.
abstract: The relationship of prostatic intraepithelial neoplasia (PIN) and invasive carcinoma of the prostate is not fully understood. It is generally accepted that HGPIN is a probable preinvasive malignant change or at least a marker lesion for carcinoma. The prevalence of HGPIN in younger men is not known. Two hundred and forty nine entirely processed prostates from men aged 20-69 were thoroughly evaluated for the presence of PIN and carcinoma. The histologic diagnosis of all positive cases was confirmed by two pathologists. Our results are summarized as follows: Seventy seven percent of the prostates with HGPIN harbored adenocarcinoma, whereas the frequency of cancer in prostates without HGPIN was 24%. HGPIN was encountered in 0, 5, 10, 41 and 63% of men in the 3rd, 4th, 5th and 7th decades, respectively. The corresponding figures for invasive carcinoma were 2, 29, 32, 55, and 64% respectively.
authors: Department of Pathology, Harper Hospital, Detroit, Michigan 48201.
authors: W A
authors: WA
authors: Sakr
authors: D J
authors: DJ
authors: Grignon
authors: J D
authors: JD
authors: Crissman
authors: L K
authors: LK
authors: Heilbrun
authors: B J
authors: BJ
authors: Cassin
authors: J J
authors: JJ
authors: Pontes
authors: G P
authors: GP
authors: Haas
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001344:Autopsy; D044383:Black People; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology; D044465:White People