title: Prospective study of the impact of broad-spectrum antibiotics on the yeast flora of the human gut.
abstract: The effects of four antibiotics on the yeast flora of the human gut were evaluated. Forty adult cancer patients who received therapy with amoxicillin-clavulanate, ciprofloxacin, sulfamethoxazole-trimethoprim or ampicillin were studied prospectively. Quantitative stool cultures for yeasts were performed immediately before, at the end of and one week after the end of the antibiotic treatment. Amoxicillin-clavulanate caused a higher and more persistent increase in gastrointestinal colonization by yeasts compared to ciprofloxacin, sulfamethoxazole-trimethoprim or ampicillin. The present results are similar to those obtained in a mouse model of gastrointestinal colonization by Candida albicans when the same antibiotics were used.
authors: Department of Medicine, University of Crete, Greece.
authors: G
authors: G
authors: Samonis
authors: A
authors: A
authors: Gikas
authors: P
authors: P
authors: Toloudis
authors: S
authors: S
authors: Maraki
authors: G
authors: G
authors: Vrentzos
authors: Y
authors: Y
authors: Tselentis
authors: N
authors: N
authors: Tsaparas
authors: G
authors: G
authors: Bodey
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology; D002969:Clavulanic Acids / Q000494:pharmacology; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D002939:Ciprofloxacin; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination