Transient hepatic dysfunction in two brothers receiving heparin and streptokinase: a genetic predisposition?
Two brothers with acute myocardial infarction are presented. Subsequent to a standard thrombolysis treatment with streptokinase and heparin, both developed abnormal liver tests, with elevated transaminases only. This liver dysfunction resolved promptly. The occurrence of such side-effects in two siblings raises the question of genetic predisposition to the otherwise uncommon hepatic complications of thrombolysis treatment.
Pipek
R
R
Department of Internal Medicine D, Rambam Medical Centre, Haifa, Israel.
Avizohar
O
O
Levy
Y
Y
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008107:Liver Diseases / Q000235:genetics*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000235:genetics; D013300:Streptokinase / Q000009:adverse effects* / Q000627:therapeutic use; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D005723:gamma-Glutamyltransferase / Q000097:blood
D006493:Heparin; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013300:Streptokinase