Peptides derived from the granins (chromogranins/secretogranins).
This review summarizes the role of granins (chromogranins/secretogranins) as precursors to biologically active peptides. We discuss the structural basis of the proteolytic processing of the granins, the consequences of their processing and the biological effects of granin-derived peptides.
Natori
S
S
Institute for Neurobiology, University of Heidelberg, Germany.
Huttner
W B
WB
D000595:Amino Acid Sequence; D000818:Animals; D002864:Chromogranins / Q000737:chemistry* / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000378:metabolism; D009928:Organ Specificity; D043484:Proprotein Convertases; D011498:Protein Precursors / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D013379:Substrate Specificity; D013381:Subtilisins / Q000378:metabolism
D002864:Chromogranins; D009479:Neuropeptides; D011498:Protein Precursors; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; D010450:Endopeptidases; D043484:Proprotein Convertases; D013381:Subtilisins; C058751:KEX2 protein, S cerevisiae