title: Changes in end-expiratory lung volume on induction of anaesthesia with thiopentone or propofol.
abstract: To determine the effects of induction agent and obesity on the change in functional residual capacity caused by induction of anaesthesia, we measured the change in end-expiratory respiratory volume (EERV) during induction of anaesthesia with either thiopentone or propofol. Female patients breathed via a face mask from a closed circle system connected to a water spirometer. The spirometer tracing was used to measure the decrease in EERV. The median decrease was 200 (95% confidence limits 90-280) ml after thiopentone and 285 (200-425) ml after propofol. The decrease in each group was significant (P < 0.01) but there was no difference between the two groups. The change in EERV, expressed as a proportion of the predicted functional residual capacity, was not related to obesity (estimated as the ratio of actual to predicted body weight).
authors: Department of Anaesthetics, Royal Infirmary, Edinburgh.
authors: J S
authors: JS
authors: Rutherford
authors: M R
authors: MR
authors: Logan
authors: G B
authors: GB
authors: Drummond
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D008397:Masks; D009765:Obesity / Q000503:physiopathology; D015742:Propofol; D012115:Residual Volume; D013874:Thiopental; D013997:Time Factors
chemical_list: D013874:Thiopental; D015742:Propofol