title: Continuous aspiration of subglottic secretions in preventing ventilator-associated pneumonia.
abstract: OBJECTIVE
  To determine whether continuous subglottic aspiration prevents nosocomial pneumonia in mechanically ventilated patients.
  
  
  METHODS
  A randomized, controlled, blinded study.
  
  
  METHODS
  Medical-surgical intensive care unit.
  
  
  METHODS
  190 patients who were admitted to the intensive care unit during a 33-month period and whose condition suggested the need for prolonged intubation (> 3 days).
  
  
  METHODS
  76 patients were randomly allocated to receive continuous aspiration of subglottic secretions, and 77 control patients were allocated to receive usual care.
  
  
  METHODS
  The numbers of cases of ventilator-associated pneumonia, ventilated days, days in intensive care unit, and deaths were recorded. The amount of subglottic secretions aspirated daily and surveillance cultures in the subglottic secretions were also obtained periodically. Etiologic diagnosis was based on the quantitative culture of secretions obtained by protected specimen brush or bronchoalveolar lavage.
  
  
  RESULTS
  The incidence rate of ventilator-associated pneumonia was 19.9 episodes/1000 ventilator days in the patients receiving continuous aspiration of subglottic secretions and 39.6 episodes/1000 ventilator days in the control patients (relative risk, 1.98; 95% CI, 1.03 to 3.82). This difference was due to a significant (P < 0.03) reduction in the number of gram-positive cocci and Haemophilus influenzae organisms in the patients receiving continuous aspiration. However, no differences were observed in the number of Pseudomonas aeruginosa or Enterobacteriaceae organisms. Episodes of ventilator-associated pneumonia occurred later in patients receiving continuous aspiration (12.0 +/- 7.1 days) than in the control patients (5.9 +/- 2.1 days) (P = 0.003). The same microorganisms isolated from protected specimen brush or bronchoalveolar lavage cultures in patients with ventilator-associated pneumonia were previously isolated from cultures of subglottic secretions in 85% of cases. No significant differences in outcome were found.
  
  
  CONCLUSIONS
  The incidence of nosocomial pneumonia in mechanically ventilated patients can be significantly reduced by using a simple method that decreases the chronic microaspirations through the cuff of endotracheal tubes.
authors: Intensive Care Department, Hospital de Sabadell, Barcelona, Spain.
authors: J
authors: J
authors: Vallés
authors: A
authors: A
authors: Artigas
authors: J
authors: J
authors: Rello
authors: N
authors: N
authors: Bonsoms
authors: D
authors: D
authors: Fontanals
authors: L
authors: L
authors: Blanch
authors: R
authors: R
authors: Fernández
authors: F
authors: F
authors: Baigorri
authors: J
authors: J
authors: Mestre
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003428:Cross Infection / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005931:Glottis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000009:adverse effects*; D012307:Risk Factors; D013396:Suction; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents