title: Anti-Candida activity of synthetic hydroxychalcones.
abstract: The antifungal activity of different synthetic hydroxychalcones was determined against Candida species. It was revealed that the presence of hydroxyl groups at C-2, C-4, and C-2' in chalcone was essential to inhibit Candida growth. Among the chalcone derivatives examined, 2,4,2'-trihydroxy-5'-methylchalcone showed the most intensive anti-Candida activity, suggesting that it could be a potential therapeutic agent for candidosis.
authors: Department of Dental Pharmacology, Asahi University School of Dentistry, Gifu, Japan.
authors: H
authors: H
authors: Tsuchiya
authors: M
authors: M
authors: Sato
authors: M
authors: M
authors: Akagiri
authors: N
authors: N
authors: Takagi
authors: T
authors: T
authors: Tanaka
authors: M
authors: M
authors: Iinuma
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002175:Candida / Q000187:drug effects*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D002599:Chalcone