Dose-response relationship for radiation carcinogenesis in the low-dose region.
Evidence that low-level radiation substantially enhances the effectiveness of repair mechanisms is summarized. This finding destroys the theoretical basis (there is no other basis) for use of a linear-no threshold dose-response relationship to estimate the cancer risk of exposure to low-level radiation. Such a methodology will exaggerate the risk. This conclusion is further supported by epidemiological evidence and by studies of the effects of radon exposure in the home, which are reviewed.
Cohen
B L
BL
University of Pittsburgh, PA 15260.
D000818:Animals; D002274:Carcinogens, Environmental / Q000009:adverse effects; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011886:Radon / Q000009:adverse effects; D012307:Risk Factors
D002274:Carcinogens, Environmental; D004247:DNA; D011886:Radon