title: Profiles of emetic action of cisplatin in the ferret: a potential model of acute and delayed emesis.
abstract: The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was investigated in the ferret over a 72 and 40 h period respectively. Cisplatin 10 mg/kg induced retching and vomiting which rapidly declined after the first 8 h. Cisplatin 5 mg/kg induced a less intense emetic response which declined after 16 h but reappeared at approximately 32 h to reveal a 'delayed' retching and vomiting response. The use of cisplatin 5 mg/kg may offer a regimen to model cytotoxic acute and delayed emesis.
authors: School of Pharmacy, University of Bradford, UK.
authors: J A
authors: JA
authors: Rudd
authors: C C
authors: CC
authors: Jordan
authors: R J
authors: RJ
authors: Naylor
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005289:Ferrets; D007274:Injections, Intraperitoneal; D008297:Male; D014839:Vomiting / Q000139:chemically induced*
chemical_list: D002945:Cisplatin