Synthesis of some 4-thiazoline and 4H-1,2,4-triazole derivatives of imidazo[1,2-a]pyridine as possible anticonvulsants.
Several 2-[(2-methylimidazo[1,2-a]pyridine-3-yl)carbonyl]hydrazono- 3-nonsubstituted/substituted-4-phenyl-4-thiazolines (3a-d, 3f-h) and 3-(2-methylimidazo[1,2-a]pyridine-3-yl)-4-nonsubstituted/substitut ed-5- mercapto-4H-1,2,4-triazoles (4a-f, 4i) were synthesized, characterized and evaluated for anticonvulsant activity. Only 3g showed significant activity against MES induced seizures.
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Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Istanbul, Turkey.
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D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D011725:Pyridines; D013844:Thiazoles; D014230:Triazoles