[Acute pancreatitis in children with acute lymphoblastic leukemia treated with L-asparaginase].
The treatment of the acute lymphoblastic leukemia in childhood includes frequent administration of L-asparaginase by intravenous route. L-asparaginase is an enzyme produced by E. coli and Erwinia chrysanthemi strains. Adverse reactions produced by L-asparaginase are numerous, and pancreatitis is being the most severe. Children with the acute lymphoblastic leukemia were followed up for 2 years. Hyperglycaemia and glycosuria were noted in 10% of them resulting in L-asparaginase cessation or replacement by less toxic agents. The acute pancreatitis was produced in 8% of the patients, and was treated typically.
Wlazłowski
M
M
I Kliniki Chorób Dzieci w Gdańsku.
Celińska
W
W
Maciejka-Kapuścińska
L
L
Płoszyńska
A
A
Idczak
E
E
D000208:Acute Disease; D001215:Asparaginase / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
D001215:Asparaginase
Ostre zapalenie trzustki u dzieci z ostra białaczka limfoblastycana leczonych L-asparaginaza.