Fluctuations in circulating cell numbers following chemotherapy or bone marrow transplant.
We study the effect of noise on the behaviour of a dynamic cell population model in which cell replication and maturation take place simultaneously. We assume that the maximum proliferative potential v fluctuates uniformly about a mean value of v, and show that a decrease in v and/or the input flux uin into the population can lead to an increase in the variance in the cellular efflux uf. We draw a qualitative correspondence between this behaviour and the commonly observed increase in the variance of circulating blood cell numbers following chemotherapy and radiotherapy, both of which lead to a decrease in v and uin, and bone marrow transplant which probably corresponds to a decrease in uin.
Schwegler
H
H
Institute of Theoretical Physics, University of Bremen, Germany.
Mackey
M C
MC
D001773:Blood Cells / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D016026:Bone Marrow Transplantation / Q000502:physiology*; D002455:Cell Division; D004358:Drug Therapy; D004921:Erythropoietin / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical
D004921:Erythropoietin