The effect of captopril on the oxidation of plasma lipoproteins.
The antihypertensive drug captopril was found to inhibit the oxidation of low density lipoproteins by copper in a dose dependent manner in vitro. Up to 65% inhibition of oxidation was observed at the concentration of 100 micrograms/ml of captopril. During subsequent studies with patients, captopril protected low density lipoproteins against oxidation slightly better than enalapril, although this difference was not statistically significant. Captopril had no effect on the levels of Lp(a) as compared to the levels established during enalapril treatment.
Clearfield
M B
MB
Department of Medicine, University of North Texas Health Science Center, Fort Worth.
Lee
N
N
Armstrong
L
L
DeFazio
P
P
Kudchodkar
B J
BJ
Lacko
A G
AG
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004656:Enalapril / Q000494:pharmacology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy; D008054:Lipid Peroxides / Q000032:analysis; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction
D008054:Lipid Peroxides; D008074:Lipoproteins; D004656:Enalapril; D002216:Captopril