Renal tissue endothelin in long-term complete ureteric obstruction in the young rat.
Complete obstruction of one ureter was created in 3-week-old weanling rats. The endothelin concentration in the renal tissue was measured by radioimmunoassay. In the obstructed kidney, a substantial increase was observed, after 1 week +90%, after 2 weeks +55%, and after 4 weeks +145% compared to the control rat kidneys. The endothelin-1/endothelin-3 ratio was found to be considerably raised, indicating a predominance of the vasoconstrictor effects of the--with reference to vasoactivity--bi-potential endothelin. Its contribution to vasoconstriction and to glomerular destruction in obstructive nephropathy is discussed.
Josephson
S
S
Department of Paediatric Surgery, St. Göran's Children's Hospital, Stockholm, Sweden.
Hemsén
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A
D000818:Animals; D000831:Animals, Newborn; D016232:Endothelins / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014517:Ureteral Obstruction / Q000378:metabolism*
D016232:Endothelins