Neonatal onset of medium-chain acyl-coenzyme A dehydrogenase deficiency with confusing biochemical features.
A female neonate was seen because of shock, ketosis, and undetectable blood glucose. Initial urinary findings indicated the possibility of a defect of fatty acid beta-oxidation; subsequent studies showed that she had medium-chain acyl-coenzyme. A dehydrogenase deficiency. This case highlights the fact that the initial symptoms may occur in the first few days of life, and that the presence of ketosis does not exclude the possibility of a fatty acid oxidation defect; the profiles of urinary organic acids and acylglycines may not be characteristic at that time.
Christodoulou
J
J
Department of Paediatrics and Child Health, University of Sydney, Australia.
Hoare
J
J
Hammond
J
J
Ip
W C
WC
Wilcken
B
B
D042964:Acyl-CoA Dehydrogenase; D001786:Blood Glucose / Q000032:analysis; D002331:Carnitine / Q000097:blood; D044943:Fatty Acid Desaturases / Q000172:deficiency*; D005227:Fatty Acids / Q000652:urine; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007662:Ketosis / Q000175:diagnosis / Q000652:urine; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000008:administration & dosage / Q000627:therapeutic use
D001786:Blood Glucose; D005227:Fatty Acids; D044943:Fatty Acid Desaturases; D042964:Acyl-CoA Dehydrogenase; D002331:Carnitine; D010634:Phenobarbital