[Changes in the chrono-inotropic properties of the myocardium and oxygen consumption as affected by strophanthin-K, isoptin and their combination].
In the experiments on isolated frog atria isometrically contracting, the author studied myocardial contractility and oxygen consumption under the action of strophanthin K, isoptin, and their combination. Strophanthin was demonstrated to exert two-phase effects on the inotropic function of an isolated myocardial stripe, which depended on the time of cardiotonic action. The calcium antagonist isoptin in combination with strophanthin K reduced myocardial oxygen uptake, potentiated the negative chronotropic effect of the cardiac glycoside, decreased the cardiostimulant action of the latter, slowing down its development.
Lemkina
S M
SM
D000818:Animals; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D011895:Rana ridibunda; D013328:Strophanthins / Q000494:pharmacology*; D014700:Verapamil / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D013328:Strophanthins; D014700:Verapamil; C029082:strophanthin K
Izmeneniia khronoinotropnykh svoĭstv miokarda i potrebleniia im kisloroda pod vliianiem strofantina-K, izoptina i ikh kombinatsii.