Induction of Cu,Zn-superoxide dismutase after cortical contusion injury during hypothermia.
To determine the effect of hypothermia on superoxide injury after cerebral contusion, the induction of Cu,Zn-superoxide dismutase was examined 6 h after contusion in rats using Northern blotting. Cu,Zn-superoxide dismutase gene expression increased at the periphery of the contusion, which may indicate the severity of the superoxide stimulus. This increase was preserved after contusion under hypothermia, which may show that superoxide injury is still severe although brain edema is decreased.
Fukuhara
T
T
Department of Neurological Surgery, Okayama University Medical School, Japan.
Nishio
S
S
Ono
Y
Y
Kawauchi
M
M
Asari
S
S
Ohmoto
T
T
D000818:Animals; D015152:Blotting, Northern; D001833:Body Temperature Regulation / Q000502:physiology*; D001924:Brain Concussion / Q000201:enzymology*; D004790:Enzyme Induction; D015870:Gene Expression; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000235:genetics
D013482:Superoxide Dismutase