Design and analysis of chromosome physical mapping experiments.
Mathematical and statistical aspects of constructing ordered-clone physical maps of chromosomes are reviewed. Three broad problems are addressed: analysis of fingerprint data to identify configurations of overlapping clones, prediction of the rate of progress of a mapping strategy and optimal design of pooling schemes for screening large clone libraries.
Balding
D J
DJ
School of Mathematical Sciences, Queen Mary & Westfield College, University of London, U.K.
D002874:Chromosome Mapping / Q000379:methods*; D003001:Cloning, Molecular; D016172:DNA Fingerprinting; D015723:Gene Library; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D013223:Statistics as Topic