Brain SPECT imaging for laminar heterotopia.
Brain perfusion SPECT was performed in an epileptic patient with a rare form of diffuse subcortical laminar heterotopia using 99mTc-HMPAO. MRI demonstrated generalized laminar heterotopia underlying the cortical mantle. Interictal SPECT imaging revealed identical or increased perfusion of the laminar heterotopia as compared with that of the overlying cortical mantle. Moreover, SPECT revealed low perfusion in the left temporal lobe that agreed with the seizure type of complex partial seizures and the EEG finding of frequent generalized spike-wave complexes with a slight left-sided dominance. Brain SPECT imaging may be useful for appropriate diagnosis of gray matter heterotopia and for detection of functionally focal abnormality associated with epilepsy.
Matsuda
H
H
Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, NCNP, Tokyo, Japan.
Onuma
T
T
Yagishita
A
A
D000328:Adult; D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D004827:Epilepsy / Q000209:etiology; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology; D015899:Tomography, Emission-Computed, Single-Photon