Effect of an endovascular stent on healing of an end-to-end polytetrafluoroethylene-artery anastomosis in a canine model.
A canine model of end-to-end anastomosis between the iliac arteries and polytetrafluoroethylene grafts was developed; a self-expanding Wallstent was placed across one anastomosis. The opposite limb acted as a control. Animals were killed at 4 or 12 weeks. Sections were taken and the intimal thickness and luminal area calculated. At 12 weeks intimal thickness was significantly greater at anastomoses in control sections (P = 0.007), and at the interface between the proximal stent and graft in stented graft limbs (P = 0.01). Control graft limbs had significantly enhanced intimal thickness at the anastomotic level at 12 weeks compared with that at 4 weeks (P = 0.0002), while there was no such increase for the stented side. There was no significant difference in luminal area between control and stented graft limbs. Anastomotic neointimal hyperplasia in a canine graft-artery bypass model is modified by endovascular stenting.
Chalmers
R T
RT
Department of Surgery, University of Iowa, Iowa City.
Hoballah
J J
JJ
Sharp
W J
WJ
Kresowik
T F
TF
Corson
J D
JD
D000714:Anastomosis, Surgical; D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D006965:Hyperplasia / Q000473:pathology; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008855:Microscopy, Electron, Scanning; D011138:Polytetrafluoroethylene; D015607:Stents; D017539:Tunica Intima / Q000473:pathology*; D014463:Ultrasonography; D014945:Wound Healing
D011138:Polytetrafluoroethylene