title: Breast cancer in first degree relatives of 180 female breast cancer patients.
abstract: The risk of breast cancer and of all malignancies was assessed in first degree relatives of 180 women with breast cancer using a historical cohort study approach. The standardized incidence ratio (SIR) was significantly (p < 0.05) increased for breast cancer in mothers: 1.97 (95% Confidence Interval (CI): 1.27 to 2.91) and in all female first degree relatives: 1.55 (95% CI: 1.08 to 2.15). For breast cancer in sisters it was 1.12 (95% CI: 0.56 to 2.01). For all malignancies the SIR for mothers was 1.12 (95% CI: 0.85 to 1.44), for sisters 1.09 (95% CI: 0.77 to 1.49) and for all female first degree relatives 1.08 (95% CI: 0.89 to 1.32). This study confirms previous investigations showing that breast cancer occurs more frequently in female first degree relatives of women with breast cancer than in the general population.
authors: Computing Department, University of Basel, Switzerland.
authors: G
authors: G
authors: Fürstenberger
authors: H
authors: H
authors: Christen
authors: C E
authors: CE
authors: Minder
authors: M
authors: M
authors: Spycher
authors: W
authors: W
authors: Weber
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors; D013557:Switzerland / Q000453:epidemiology