The effect of nebulized salbutamol therapy on the incidence of postoperative chest infection in high risk patients.
Patients who smoke heavily and those with pre-existing airflow obstruction are at particular risk of postoperative respiratory infection following upper abdominal surgery. This invariably prolongs hospital stay and increases morbidity. In order to determine whether high dose bronchodilator therapy in the perioperative period reduced the risk of infection, all patients undergoing elective upper abdominal surgery were assessed for risk of developing postoperative infection. Fifty-three patients were identified as high risk according to previously published criteria and were randomly allocated to receive nebulized salbutamol (5 mg) or saline placebo 6 hourly for 48 h beginning 1 h preoperatively. There was no difference in rates of postoperative chest infection in the two groups and this study, therefore, provides no support for the routine preoperative use of bronchodilators in these patients.
Dilworth
J P
JP
Department of Medicine, Frenchay Hospital, Bristol, U.K.
Warley
A R
AR
Dawe
C
C
White
R J
RJ
D000368:Aged; D000420:Albuterol / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D012141:Respiratory Tract Infections / Q000517:prevention & control*
D000420:Albuterol