[A cytological study of inhibition of secondary cataract with heparin].
Secondary cataract is caused primarily by migration and proliferation of fibroblasts on the posterior capsular surface after extracapsular cataract extraction. Human fetus skin fibroblast cell culture was used, by measurement of cell's life cycle, cellular DNA content, increase of cell number and density, to investigate the heparin inhibitory action on the growth of the cells. It is discovered that the growth rate of the fibroblasts is lowered in the culture medium with heparin and the inhibition takes place at the interval between G1 and S stage and at M stage of the cell's life cycle.
Xia
X P
XP
Department of Ophthalmology, Xinhua Hospital, Shanghai Second Medical University.
Lu
D Y
DY
Wang
L T
LT
D002386:Cataract / Q000209:etiology*; D002453:Cell Cycle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D005333:Fetus; D005347:Fibroblasts / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D012867:Skin / Q000166:cytology
D006493:Heparin; D004247:DNA