title: Tympanic electrocochleography for diagnosis of Menière's disease.
abstract: OBJECTIVE
  Tympanic electrocochleography (ECOG) is a noninvasive technique for recording cochlear potentials with an electrode placed on the tympanic membrane. Electrocochleography is used clinically in the evaluation of patients for endolymphatic hydrops. This study was undertaken to obtain normative data for ECOG responses to clicks and tone bursts and to determine clinical indicators that result in high test specificities.
  
  
  METHODS
  Three cochlear potentials were measured; the eighth nerve compound action potential, the cochlear microphonic, and the summating potential. The subjects were 53 normal hearing adults with negative histories for symptoms of Menière's disease. The ECOG responses were measured with a silver wire-rayon wick electrode that was placed on the tympanic membrane under direct microscopic visualization. Stimuli were condensation, rarefaction, and alternating polarity clicks and 1- and 2-kHz tone bursts.
  
  
  RESULTS
  Measures that appear to be useful in the evaluation of endolymphatic hydrops include the summating potential to action potential ratio, action potential latency difference to condensation and rarefaction clicks, and the tone-burst-evoked summating potential. Relationships among these measures were investigated, and abnormal criteria were determined that result in test specificities of 95%.
  
  
  CONCLUSIONS
  Menière's disease is viewed as a progressive disease in which ECOG characteristics vary with the disease state. Cases are presented to illustrate ECOG responses in various stages of the disease. The normative data presented in this article are useful for the detection of Menière's disease in its early stages.
authors: Department of Otolaryngology, University of Minnesota, Minneapolis.
authors: R H
authors: RH
authors: Margolis
authors: D
authors: D
authors: Rieks
authors: E M
authors: EM
authors: Fournier
authors: S E
authors: SE
authors: Levine
mesh_terms: D000328:Adult; D001300:Audiometry, Evoked Response / Q000379:methods*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008564:Membrane Potentials; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged; D015203:Reproducibility of Results; D014432:Tympanic Membrane / Q000502:physiology; D000159:Vestibulocochlear Nerve / Q000502:physiology