Leuprolide acetate depot for the treatment of uterine leiomyomas. Changes in bone density, uterine volume and uterine vascular resistive index.
This study measured the changes in uterine volume, uterine vascular resistive index and lumbar vertebral bone density before and after a six-month course of leuprolide acetate depot in women with uterine leiomyomas. All nine patients studied were black. The high baseline bone density of black women may provide a greater scope for the use of gonadotropin agonists as compared to women in the general population. A significant reduction in uterine volume was achieved in the patients with leuprolide therapy. Uterine vascular resistive indices were not altered consistently following leuprolide therapy in women with leiomyomas.
Rivlin
M E
ME
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson.
Patel
R B
RB
Hess
L W
LW
Hess
D B
DB
Meeks
G R
GR
D000328:Adult; D044383:Black People; D015519:Bone Density / Q000187:drug effects*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D016729:Leuprolide / Q000494:pharmacology / Q000627:therapeutic use*; D009929:Organ Size / Q000187:drug effects; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D014655:Vascular Resistance / Q000187:drug effects*
D003692:Delayed-Action Preparations; D016729:Leuprolide