title: Anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis in rats.
abstract: The anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis was investigated. Local application of this manganese superoxide dismutase given every 2 days not only significantly reduced foot swelling but also retarded radiological bone destruction in adjuvant arthritis. Copper zinc superoxide dismutase had little effect on foot swelling.
authors: Department of Clinical Immunology, Kyushu University, Beppu, Japan.
authors: M
authors: M
authors: Shingu
authors: S
authors: S
authors: Takahashi
authors: M
authors: M
authors: Ito
authors: N
authors: N
authors: Hamamatu
authors: Y
authors: Y
authors: Suenaga
authors: Y
authors: Y
authors: Ichibangase
authors: M
authors: M
authors: Nobunaga
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins; D013482:Superoxide Dismutase / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011994:Recombinant Proteins; D013482:Superoxide Dismutase