Immunopathogenesis and treatment of the Guillain-Barré syndrome--Part II.
In the second part of our review the role of antecedent infections in the pathogenesis of GBS is discussed. The association with Campylobacter jejuni (C. jejuni) is highlighted and the concept of molecular mimicry, i.e., sharing of epitopes between microbes and peripheral nerve, explained. Alternative mechanisms to relate an infection with the immune-mediated neuropathy are elaborated. Current therapies of the GBS include plasma exchange, high-dose intravenous immunoglobulins, and supportive treatment directed to secondary complications. Published therapeutic trials are reviewed and future approaches are outlined. Principles of general care are also summarized.
Hartung
H P
HP
Department of Neurology, Julius-Maximilians-Universität, Würzburg, Germany.
Pollard
J D
JD
Harvey
G K
GK
Toyka
K V
KV
D002169:Campylobacter Infections; D016123:Campylobacter jejuni; D006801:Humans; D018716:Molecular Mimicry; D011129:Polyradiculoneuropathy / Q000276:immunology / Q000382:microbiology* / Q000628:therapy*