The basic reproduction ratio of HIV among intravenous drug users.
A new approach for the estimation of the Basic Reproduction Ratio R0 for HIV among intravenous drug users (IVDU) is proposed. This approach is based in an adaptation of the models proposed by Ross and Macdonald for vector-borne infections. A straightforward adaptation of Macdonald's model is presented first: biological vectors are replaced by needles and syringes and we consider a homogeneous population of IVDUs; next we present a modified model where several heterogeneities are considered. Some of those heterogeneities are due to intrinsic differences between needles and syringes and biological vectors; others, such as those related to movements of individuals between communities, should apply to both biological vectors and injection apparatuses. An example of the calculations of R0 for a real IVDUs community is presented.
Massad
E
E
School of Medicine, University of São Paulo, Brazil.
Coutinho
F A
FA
Yang
H M
HM
De Carvalho
H B
HB
Mesquita
F
F
Burattini
M N
MN
D000818:Animals; D004199:Disease Vectors; D015658:HIV Infections / Q000150:complications* / Q000635:transmission*; D006801:Humans; D008288:Malaria / Q000150:complications / Q000635:transmission; D008433:Mathematics; D008954:Models, Biological; D016485:Needle Sharing / Q000009:adverse effects; D015819:Substance Abuse, Intravenous / Q000150:complications*