Serum interleukin 1 beta levels as a marker in hairy cell leukemia: correlation with disease status and sIL-2R levels.
Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder of the B cell lineage. In the search for specific markers with prognostic significance we evaluated the clinical value of IL-1 beta and sIL-2R levels in HCL patients. HCL patients (25) were classified according to their clinical status as "active", "non active" disease or partial or complete remission and response treatment. We found a good correlation between IL-1 beta or IL-2R levels and disease activity: improved clinical status or response to different therapies were associated with decreasing IL-1 beta or sIL-2R levels. In contrast, lack of response to therapy or disease progression was reflected in increases in both IL-1 beta and sIL-2R levels. In some patients increases of both cytokines preceded clinical symptoms. In conclusion our results show that IL-1 beta and s-IL-2R levels may be used as reliable markers for monitoring HCL activity, assessing response to treatment and predicting early progression of disease.
Barak
V
V
Department of Hematology, Hadassah University Hospital, Hebrew University Medical School, Jerusalem, Israel.
Nisman
B
B
Dann
E J
EJ
Kalickman
I
I
Ruchlemer
R
R
Bennett
M A
MA
Polliack
A
A
D014408:Biomarkers, Tumor / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007943:Leukemia, Hairy Cell / Q000097:blood* / Q000473:pathology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012995:Solubility
D014408:Biomarkers, Tumor; D007375:Interleukin-1; D015375:Receptors, Interleukin-2