[The effect of deprenil on the dopaminergic system of the brain in mice of different genotypes during aging].
Effects of aging on brain dopaminergic system, e.g., neurotransmitter metabolism and different kinds of dopamine-dependent behaviour, were studied in mice of three inbred strains. Homovanillic acid concentrations in structures of both nigrostriatal (striatum) and mesolimbic (n. accumbens with tuberculum olfactorium) systems were found to be increased in the aged animals. Aged mice of the strains studied were characterized by decreased locomotor activity and stereotypic climbing; CC57Br mice, in contrast to A/He and C3H/He, demonstrated significantly diminished level of investigatory activity. However, genotypic differences in these kinds of behaviour were less pronounced in the aged animals in comparison to the young adults, but interstrain differences in swimming activity (Porsolt's "despair test") which was almost unchanged in aged mice, remained enough pronounced. In the aged mice postsynaptic dopamine receptor sensitivity, assessed after administration of a high dose of the mixed agonist apomorphine, was markedly decreased. Chronic treatment with deprenyl, a specific MAO-B inhibitor, produced a clear-cut genotype-dependent effect on investigatory activity in the aged animals. High level of this activity, characteristic for the young adults, was restored in CC57Br, in A/He it was elevated in comparison both with young and old untreated animals, and the same tendency was observed in C3H/He. This fact seems to reflect an interesting property of deprenyl to increase general adaptation in the aged organism, that might have valuable clinical implications.
Skrinskaia
Iu A
IuA
Nikulina
E M
EM
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D005838:Genotype; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D012642:Selegiline / Q000494:pharmacology*
D011954:Receptors, Dopamine; D012642:Selegiline
Vliianie deprenila na dofaminergicheskuiu sistemu mozga mysheĭ razlichnykh genotipov pri starenii.