Complex formation of human alpha-1-antitrypsin with components in Schistosoma mansoni cercariae.
Human alpha-1-antitrypsin (alpha 1-AT) was incubated with an extract of Schistosoma mansoni cercariae or porcine pancreatic elastase and analysed by immunoelectrophoresis and Western blotting. The inhibitor was shown to form complexes with components in S. mansoni cercariae in the same way as elastase. The role of alpha 1-AT in S. mansoni infection is discussed.
Modha
J
J
Department of Biochemistry, University of Glasgow, UK.
Doenhoff
M J
MJ
D000818:Animals; D015153:Blotting, Western; D002457:Cell Extracts; D006801:Humans; D007122:Immunoelectrophoresis; D010196:Pancreatic Elastase / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000201:enzymology*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D002457:Cell Extracts; D000515:alpha 1-Antitrypsin; D010196:Pancreatic Elastase