[Does vitamin E protect against experimental lithiasis?].
We have recently suggested that vitamin A could protect against experimental lithiasis by repairing tubular membrane cells or protection against membrane damage caused by free radicals generated during experimental lithiasis. Although vitamin E treatment demonstrated no beneficial effect on stone formation, it promoted the repair mechanism by vitamin A during experimental lithiasis and by supported the hypothesis that oxalate crystals may be destructive to renal epithelium because they are large and irregular.
Sakly
A
A
Ecole Supérieure des Sciences et Techniques de la Santé, Monastir, Tunisie.
Achour
A
A
Zouaghi
H
H
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D004357:Drug Synergism; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005609:Free Radicals / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007669:Kidney Calculi / Q000378:metabolism / Q000517:prevention & control*; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D010070:Oxalates / Q000009:adverse effects / Q000378:metabolism; D019815:Oxalic Acid; D051381:Rats; D017208:Rats, Wistar; D014508:Urea / Q000097:blood / Q000378:metabolism; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
D005609:Free Radicals; D010070:Oxalates; D014801:Vitamin A; D014810:Vitamin E; D014508:Urea; D019815:Oxalic Acid; D002118:Calcium
La vitamine E protège-t-elle contre la lithiase expérimentale?