title: High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium.
abstract: Lithium (Li) reduces brain inositol levels. Berridge has suggested that this effect is related to Li's mechanism of action. It had previously been shown that pilocarpine causes a limbic seizure syndrome in lithium treated rats, and that these lithium-pilocarpine seizures are reversible by intracerebroventricular inositol administration to rats. We now show that although inositol passes the blood-brain barrier poorly, large doses of intraperitoneal (IP) inositol can also reverse Li-pilocarpine seizures. Using gas chromatography, IP inositol can raise brain inositol levels. Demonstration that inositol enters brain after peripheral administration provides a basis for possible pharmacological intervention in psychiatric disorders at the level of second messengers linked to the phosphatidylinositol cycle.
authors: Laboratory of Biochemistry, Soroka Medical Center, Beer-Sheva, Israel.
authors: G
authors: G
authors: Agam
authors: Y
authors: Y
authors: Shapiro
authors: Y
authors: Y
authors: Bersudsky
authors: O
authors: O
authors: Kofman
authors: R H
authors: RH
authors: Belmaker
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002849:Chromatography, Gas; D005947:Glucose / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007294:Inositol / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics* / Q000494:pharmacology; D008094:Lithium / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D010862:Pilocarpine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D010862:Pilocarpine; D007294:Inositol; D008094:Lithium; D005947:Glucose