Characterization of the PSG11 gene.
The pregnancy-specific beta 1-glycoproteins (PSG) form the major group of proteins synthesized in the human placenta. There are over 30 proteins in the family, encoded by 11 genes located on chromosomes 19q13.1-13.3. The genes can be divided into three subgroups based on the C-terminal exons expressed. The subgroup 1 genes have been well characterized. In this study the organization and sequence of a complete, functional, subgroup 3 gene is described. It contains the C-terminal exons, Cw, Cr, and Cs, which are expected from the transcripts characterized. Down-stream from these exons are sequences homologous to the C-termini of the subgroup 1 type genes. This demonstrates that the subgroup 1, 2, and 3 genes are related via insertions/deletions. Comparison of the C-terminal sequences of the three subgroups of genes shows that the subgroup 2 and 3 genes are more closely related than, and are distinct from, the subgroup 1 genes.
McLenachan
P A
PA
Department of Microbiology and Genetics, Massey University, Palmerston North, New Zealand.
Rutherfurd
K J
KJ
Beggs
K T
KT
Sims
S E
SE
Mansfield
B C
BC
D000595:Amino Acid Sequence; D001483:Base Sequence; D005091:Exons; D005796:Genes; D008969:Molecular Sequence Data; D005810:Multigene Family; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000235:genetics*; D016415:Sequence Alignment; D017384:Sequence Deletion; D012689:Sequence Homology, Nucleic Acid
D011268:Pregnancy-Specific beta 1-Glycoproteins