Influence of the 5-HT1A receptor agonist ipsapirone on voluntary alcohol intake in rats.
The effect of the azapirone derivative ipsapirone on anxiety and the free-choice consumption of alcohol was studied in male rats. Animals were housed three in a cage with a different composition each day to increase anxiety. The animals were offered a two-bottle free choice consumption of tap water or a 5% ethanol solution. Ipsapirone was given in the drinking fluid daily at about 10 mg/kg per day. As expected, social unstable groups exhibited a higher level of anxiety as compared to social stable groups. Ipsapirone reduced significantly the anxiety in the unstable group. Pretreatment with ipsapirone before alcohol exposure resulted in a marked decrease of subsequent ethanol intake by about 45% as compared to drug free control animals. Administration of the drug to rats already drinking alcohol showed a similar decrease of ethanol intake by about 50%. These results indicate that the relatively specific 5-HT1A receptor agonist ipsapirone, given orally, reduces anxiety as well as alcohol initiation or maintenance in rats.
Wilde
C H
CH
Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Vogel
W H
WH
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D000431:Ethanol; C043077:ipsapirone