Vaccinoprophylaxis of mumps using mumps vaccine, strain Sofia 6, in Bulgaria.
A mumps vaccine, using strain Sofia 6 prepared in guinea-pig kidney primary cell cultures, was gradually introduced in Bulgaria to vaccinate 1- to 12-year-old children between 1972 and 1976. It was included in the national vaccine programme in 1977. The vaccine showed a slight reactogenicity, a good immunogenicity and a high epidemiological efficacy. Due to the increased morbidity of mumps, revaccination was carried out in 4- to 12-year-old children in 1982. A high level of side-effects, mainly meningitis, was registered, and led to suspension of the mumps vaccine in Bulgaria.
Department of Virology and Epidemiology, Sofia, Bulgaria.
H
H
Odisseev
N
N
Gacheva
D000818:Animals; D002031:Bulgaria; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002522:Chlorocebus aethiops; D006168:Guinea Pigs; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects; D007223:Infant; D009107:Mumps / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000009:adverse effects / Q000276:immunology*; D014709:Vero Cells
D009108:Mumps Vaccine