[Molecular and clinical abnormalities of apolipoprotein A-I].
Several epidemiological and clinical studies have shown an inverse correlation between low plasma concentration of high density lipoprotein (HDL) cholesterol as well as its major protein component, apolipoprotein A-I (apo A-I), and the risk of coronary artery disease. Apo A-I plays an important role in a reverse cholesterol transport. In this model, HDL mediates the cholesterol flux from peripheral cells to the liver. The structure and function of HDL-deficiency syndromes and apo A-I variants provides genetic markers of whether the presence of these molecular defects accounts for low HDL cholesterol levels and the coronary risk.
Takada
Y
Y
Department of Internal Medicine, School of Medicine, Fukuoka University.
Sasaki
J
J
D016632:Apolipoprotein A-I / Q000172:deficiency* / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood / Q000172:deficiency; D003327:Coronary Disease; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009154:Mutation; D012306:Risk
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL