The ability of amyloid beta-protein [A beta P (1-40)] to form Ca2+ channels provides a mechanism for neuronal death in Alzheimer's disease.
Arispe
N
N
Laboratory of Cell Biology and Genetics, NIDDK National Institutes of Health, Bethesda, Maryland 20892-0840.
Pollard
H B
HB
Rojas
E
E
D000544:Alzheimer Disease / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000502:physiology*; D015220:Calcium Channels / Q000737:chemistry / Q000502:physiology*; D016923:Cell Death; D006801:Humans; D066298:In Vitro Techniques; D015640:Ion Channel Gating; D009474:Neurons / Q000166:cytology*; D018408:Patch-Clamp Techniques; D010446:Peptide Fragments / Q000502:physiology*; D011487:Protein Conformation; D014325:Tromethamine / Q000494:pharmacology
D016229:Amyloid beta-Peptides; D015220:Calcium Channels; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D014325:Tromethamine