Novel antibiotics SF2738A, B and C, and their analogs produced by Streptomyces sp.
Three new antibiotics SF2738A, B and C, and their analogs were isolated from the culture broth of Streptomyces sp. The antibiotics are active against Gram-positive bacteria, Gram-negative bacteria and fungi, and exhibited cytotoxic activity against P388 murine leukemia cells with IC50 values of 0.08, 0.25 and 7.5 micrograms/ml, respectively. Their structures were determined by spectral analyses and chemical conversion. Especially, the structure of SF2738A was confirmed to be (E)-((4-methoxy-5-methylthio-2-(2-pyridyl)pyridin-6-yl)methylene)azan ol by X-ray crystallographic analysis.
Gomi
S
S
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Amano
S
S
Sato
E
E
Miyadoh
S
S
Kodama
Y
Y
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007941:Leukemia P388; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D011725:Pyridines; C091807:SF 2738A; C091808:SF 2738B; C091809:SF 2738C