Fibromuscular dysplasia of the brachial artery: an endovascular approach.
Fibromuscular dysplasia (FMD) is a nonatherosclerotic segmental disease of unknown etiology primarily affecting muscular arteries of intermediate size. The pathology affects the renal arteries in the majority of cases, followed by the carotid, vertebral, and ilio-femoral arteries. There have been only six reported cases of FMD involving the brachial artery. This case report describes the seventh case and illustrates an endovascular approach to this clinical entity. A 63-year-old female with a history of hypertension presented to vascular surgery clinic with a 4-day history of numbness, pain, and coolness of her left hand. On physical exam, the patient had a normal axillary and brachial pulse, but had only a Doppler signal of the left ulnar artery. There was no Doppler signal of the radial artery. Segmental pressures and PVR waveforms were normal in the upper arm, but there was a significant blunting of the waveform and decrease in pressure at the level of the wrist. An arteriogram revealed significant narrowing and irregularity of the brachial artery with a characteristic "string-of-beads" appearance. There was complete thrombosis of the radial artery and evidence of fresh thrombus in the distal brachial artery. The patient was treated with intra-arterial infusion of urokinase with restoration of the radial pulse and resolution of her symptoms. Subsequently, the patient had a percutaneous transluminal balloon angioplasty of the involved segment of brachial artery, with normal PVR's and segmental pressures upon completion. FMD of the brachial artery and its sequelae are extremely rare, and therefore, there is no consensus on proper management.(ABSTRACT TRUNCATED AT 250 WORDS)
Division of Vascular Surgery, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, New Brunswick 08903.
R G
RG
Ciocca
D L
DL
Madson
D K
DK
Wilkerson
A M
AM
Graham
D000800:Angioplasty, Balloon; D001916:Brachial Artery; D005260:Female; D005352:Fibromuscular Dysplasia / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D011674:Pulse; D017534:Radial Artery; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
D014568:Urokinase-Type Plasminogen Activator