Activity of some Mannich bases of conjugated styryl ketones against Candida albicans.
A number of Mannich bases of conjugated styryl ketones displayed activity against Candida albicans strains 3153A and B311. Antifungal potency was influenced by the relative hydrophobicities of the molecules and on occasions by the electronic nature of the aryl substituents. The compounds inhibited one or more of the following enzymes in the glutathione metabolic pathway namely glutathione S-transferases, glutathione reductase, gamma-glutamyl transpeptidase and glutathione peroxidase. Nearly half of the compounds examined on the yeast-to-mycelium transition in C. albicans 3153A prevented this conversion from occurring.
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
J R
JR
Dimmock
P
P
Kumar
E K
EK
Manavathu
N
N
Obedeanu
J
J
Grewal
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology; D005978:Glutathione / Q000378:metabolism; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008352:Mannich Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D007659:Ketones; D008352:Mannich Bases; D005978:Glutathione