EBV gene expression, EBNA antibody responses and EBV+ peripheral blood lymphocytes in post-transplant lymphoproliferative disease.
Epstein-Barr virus (EBV) is associated with the development of several B cell malignancies including Burkitt's lymphoma (BL), post-transplant lymphoproliferative disease (PTLD), and AIDS-related lymphomas. The latter two diseases result from EBV-driven B cell proliferation in the absence of normal immunosurveillance and as such, represent a heterogenous family of lymphoproliferative disorders. This article reviews studies on EBV gene expression and antibody development in PTLD and introduces recent information on the levels of EBV+ peripheral blood lymphocytes to discuss possible mechanisms of pathogenesis under varying conditions of immunosuppression.
McKnight
J L
JL
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
Cen
H
H
Riddler
S A
SA
Breinig
M C
MC
Williams
P A
PA
Ho
M
M
Joseph
P S
PS
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D001402:B-Lymphocytes / Q000821:virology; D002678:Chimera; D004268:DNA-Binding Proteins / Q000276:immunology*; D019309:Epstein-Barr Virus Nuclear Antigens; D015967:Gene Expression Regulation, Viral; D006566:Herpesviridae Infections / Q000235:genetics* / Q000276:immunology / Q000635:transmission; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D006801:Humans; D016867:Immunocompromised Host; D007157:Immunologic Surveillance; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000276:immunology / Q000821:virology*; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology / Q000821:virology*; D014180:Transplantation / Q000009:adverse effects; D014412:Tumor Virus Infections / Q000235:genetics* / Q000276:immunology / Q000635:transmission; D014764:Viral Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D014775:Virus Activation
D000914:Antibodies, Viral; D000956:Antigens, Viral; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins