[An experimental study on cultivation of human trigeminal ganglionic cell in vitro and its sensitivity to infection of herpes simplex virus type 1].
We firstly report an experimental study on the sensitivity of primary cultural human trigeminal ganglionic cells infected by herpes simplex virus type 1 (HSV-1) in different time-points. The results indicate that the neuron of human trigeminal ganglia is the most sensitive cell type, the antigen of HSV-1 replicates rapidly within the cytoplasm and cell nucleus, the fibroblasts and glia cells are infected partly by the virus. Therefore, perhaps the neuron is the main harboring cell type.
Xie
L
L
Institute of Ophthalmology, Shandong Academy of Medical Sciences, Qingdao, China.
Dong
X
X
Zhu
S
S
Zhang
D
D
Gebhardt
B M
BM
Kaufman
H E
HE
D000956:Antigens, Viral / Q000032:analysis; D002478:Cells, Cultured; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000821:virology; D012668:Trigeminal Ganglion / Q000166:cytology* / Q000821:virology*
D000956:Antigens, Viral