Radiotherapy for hepatocellular carcinoma: clinicopathological study of seven autopsy cases.
The clinical value of radiotherapy for hepatocellular carcinoma (total tumor dose: 50-70 Gy) was evaluated in seven autopsied patients with nine tumors. A partial response as defined by the WHO criteria for chemotherapy was observed in three tumors (33%). Progressive and marked shrinkage of the noncancerous liver tissue within the irradiated field was also observed in all cases. Histological examination revealed viable cancer cells in all cases. These results indicate that local radiotherapy applying 50-70 Gy achieved some clinical benefit, but was not capable of curing hepatocellular carcinoma.
Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan.
K
K
Aoki
N
N
Okazaki
S
S
Okada
H
H
Nose
M
M
Yoshimori
Y
Y
Akine
S
S
Egawa
M
M
Sakamoto
S
S
Hirohashi
D000368:Aged; D001284:Atrophy; D002102:Cadaver; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000532:radiotherapy*; D002471:Cell Transformation, Neoplastic / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology / Q000528:radiation effects*; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology; D011879:Radiotherapy Dosage; D012074:Remission Induction