Effect of hachimijiogan, an oriental herbal medicinal mixture, on experimental amnesia in mice.
The effect of Hachimijiogan on cognitive disturbance was investigated using step-through passive avoidance failure techniques: scopolamine-, cycloheximide- and cerebral ischemia-induced amnesia. Pre-acquisition trial administration of Hachimijiogan (0.5 g/kg, p.o.) prolonged the step-through latency reduced by scopolamine and cycloheximide. Hachimijiogan (0.5 and 1.0 g/kg, p.o.) also ameliorated the cerebral ischemia-induced amnesia. Physostigmine (0.1 mg/kg, i.p.) ameliorated all three amnesia models. The ameliorating effects of Hachimijiogan and physostigmine on cycloheximide-induced amnesia were diminished by the combination with scopolamine. These results suggest that Hachimijiogan possesses a wide-ranging pharmacological profile in anti-amnesic actions and that its anti-amnesic activities may be related to the cholinergic neuronal system.
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
S
S
Hirokawa
M
M
Nose
A
A
Ishige
S
S
Amagaya
Y
Y
Ogihara
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002545:Brain Ischemia / Q000523:psychology; D003071:Cognition / Q000187:drug effects; D003513:Cycloheximide; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D010830:Physostigmine; D012601:Scopolamine
D004365:Drugs, Chinese Herbal; C054591:hachimijiogan; D003513:Cycloheximide; D010830:Physostigmine; D012601:Scopolamine