High CTG repeat number in nodular thyroid tissue from a myotonic dystrophy patient.
CTG triplet expansion was studied in lymphocytes and thyroid tissue in a patient with myotonic dystrophy (DM) and associated thyroid nodular disease. An approximately 7 fold larger amplification was found in abnormal thyroid tissue compared to lymphocytes, suggesting that anomalies in the putative DM kinase gene might contribute to thyroid dysfunction.
Daumerie
C
C
Service d'Endocrinologie, Cliniques Universitaires St Luc, Brussels, Belgium.
Lannoy
N
N
Squifflet
J P
JP
Verellen
G
G
Verellen-Dumoulin
C
C
D000328:Adult; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D009030:Mosaicism; D009223:Myotonic Dystrophy / Q000150:complications / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D013959:Thyroid Diseases / Q000150:complications / Q000235:genetics; D013961:Thyroid Gland / Q000737:chemistry*
D004247:DNA