Effect of lipid absorption by perfluorochemical emulsions in the bloodstream and perspectives of its clinical application.
Studies concerning lipid absorption by perfluorochemical particles (PFC) during circulation in the blood stream have been reported in experimental animals. We studied the cholesterol absorption from high density lipoproteins (rats) and erythrocyte membrane [1] and composition of the absorbed lipids [2]. The aim of present investigation is to clarify the influence of the PFC chemical structure and synthetic emulsifier on the composition of the absorbed lipids. The perspectives of clinical application of the effect of the lipid absorption by PFC particles is discussed.
Department of Medical Biotechnology, Research Institute of Experimental and Clinical Immunology, Moscow, Russia.
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EV
Tereshina
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Afonin
D000042:Absorption; D000818:Animals; D004355:Drug Stability; D004655:Emulsions; D005079:Excipients; D005260:Female; D005466:Fluorocarbons / Q000737:chemistry / Q000493:pharmacokinetics*; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D004655:Emulsions; D005079:Excipients; D005466:Fluorocarbons; D008055:Lipids