Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy.
We examined the inferior olivary nucleus from four cases of olivary hypertrophy and six control cases immunohistochemically with an anti-synaptophysin (SYP) antibody. Our study revealed the altered SYP-immunoreactive pattern in the hypertrophied olives, consisting of an increased number of SYP-immunoreactive dots on neuronal cell bodies in spite of its decreased immunoreactivity in the neuropil. Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy.
Kawanami
T
T
Department of Pathology, Montefiore Medical Center, New York.
Kato
T
T
Llena
J F
JF
Hirano
A
A
Sasaki
H
H
D000368:Aged; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009847:Olivary Nucleus / Q000378:metabolism / Q000473:pathology*; D017729:Presynaptic Terminals / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism*
D016708:Synaptophysin