[Contribution and role of polymorphonuclear leucocytes in inflammatory reactions of asbestosis].
The mechanism of lung fibrosis after asbestos exposure is unknown. Observations suggest that neutrophils may play a role in the development of the lung injury in asbestosis. They are attracted to the lungs by macrophages mediators and there they phagocyte asbestos fibres. A cytotoxic effect of asbestos exerted on polymorphonuclear leucocytes releases proteolytic enzymes such as collagenase and elastase. Besides, asbestos produces highly reactive oxidants in neutrophils responsible for an additional damage of tissues. However, the role of polymorphonuclear leucocytes in pathogenesis of asbestosis still remains controversial.
Kliniki Chorób Wewnetrznych i Zawodowych, Akademii Medycznej we Wrocławiu.
E
E
Lewczuk
H
H
Owczarek
G
G
Staniszewska
D000818:Animals; D001195:Asbestosis / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D017364:Collagenases / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D010196:Pancreatic Elastase / Q000378:metabolism
D010196:Pancreatic Elastase; D017364:Collagenases
Udział i rola granulocytów obojetnochłonnych w reakcji zapalnej w azbestozie.