The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21.
A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17 beta-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.
Department of Medicine, Montreal General Hospital, Quebec, Canada.
P
P
Tonin
O
O
Serova
J
J
Simard
G
G
Lenoir
J
J
Feunteun
K
K
Morgan
H
H
Lynch
S
S
Narod
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D004960:Estradiol Dehydrogenases / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D011995:Recombination, Genetic
D004960:Estradiol Dehydrogenases