Histoenzymological and ultrastructural investigations regarding the role of the endogenous peroxidase at the pulmonary level in cardiogenic pulmonary hypertension.
We found optically and ultrastructurally endogenous peroxidase in 90 intraoperatory pulmonary biopsies taken from patients with valvular cardiopathies and different degrees of pulmonary hypertension. The enzymatic activity increases proportionally to the pulmonary hypertension and it reaches its maximum in severe cases of hemosiderosis. Ultrastructurally we found two reaction types namely: 1) in peroxisomes of circulating monocytes turning into tissue ones, in medium or slight pulmonary hypertension (PHT) and 2) (as granular reactions on the nuclear membrane and endoplasmic reticle in alveolar macrophages, granular pneumocytes in aggravating and severe medium PHT. The presence of both these two types of reaction in the same cell demonstrates the passing stages from circulating macrophages to tissue ones attesting a transitional process of the phagocytic cells.
Victor Babeş Institute, Bucharest, Romania.
N
N
Nicolau
G
G
Butur
L
L
Dezideriu
D006349:Heart Valve Diseases / Q000150:complications* / Q000201:enzymology / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D008168:Lung / Q000201:enzymology* / Q000648:ultrastructure; D009195:Peroxidase / Q000502:physiology*
D009195:Peroxidase