Excitatory transmitter neurotoxicity.
The major excitatory neurotransmitters in the mammalian CNS--glutamate (Glu) and acetylcholine (ACh)--have vitally important beneficial functions but also harbor treacherous neurotoxic potential which, as described in this review, can be expressed in several different ways.
Olney
J W
JW
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
D000818:Animals; D018846:Excitatory Amino Acids / Q000633:toxicity*; D006801:Humans; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D018377:Neurotransmitter Agents / Q000633:toxicity*; D017470:Receptors, Glutamate / Q000378:metabolism
D018846:Excitatory Amino Acids; D018377:Neurotransmitter Agents; D017470:Receptors, Glutamate