The role of regulated phosphorylation in the biological activity of transcription factors SRF and Elk-1/SAP-1.
The promoters of many genes whose expression is rapidly and transiently increased upon growth factor or mitogen stimulation of susceptible cells harbor a common regulatory element, the serum response element (SRE). The transcription factors that interact with the SRE of these immediate-early genes are being intensively studied so as to elucidate the signal transduction cascades that link cell surface receptors to the SRE, and to determine the mechanisms by which signal-dependent phosphorylation events modulate their function.
European Molecular Biology Laboratory, Differentiation Programme, Heidelberg, Germany.
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Papavassiliou
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D011518:Proto-Oncogene Proteins / Q000378:metabolism / Q000502:physiology*; D026362:Serum Response Factor; D014157:Transcription Factors; D050807:ets-Domain Protein Elk-1; D050808:ets-Domain Protein Elk-4
D004268:DNA-Binding Proteins; C494112:ELK1 protein, human; C494193:ELK4 protein, human; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D026362:Serum Response Factor; D014157:Transcription Factors; D050807:ets-Domain Protein Elk-1; D050808:ets-Domain Protein Elk-4