A case of nephrotic syndrome associated with protein S deficiency and cerebral thrombosis.
Protein S is found in two forms in plasma; as free and functionally active protein S, and complexed to C4b-binding protein. Patients with nephrotic syndrome are at risk for arterial and venous thrombosis at various localizations, and acquired protein S deficiency due to the selective urinary loss of the free form may be a risk factor for the development of thromboembolic complications. We report a case of cerebral arterial thrombosis associated with decreased level of free protein S antigen (44%) in a 39-year-old female patient with nephrotic syndrome.
Song
K S
KS
Department of Clinical Pathology, College of Medicine, Yonsei University, Seoul, Korea.
Won
D I
DI
Lee
A N
AN
Kim
C H
CH
Kim
J S
JS
D000328:Adult; D005260:Female; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology*; D009404:Nephrotic Syndrome / Q000150:complications*; D018455:Protein S Deficiency / Q000150:complications*