Electrical stimulation of the kindled hippocampus briefly increases extracellular dopamine in the nucleus accumbens.
The effect of electrical stimulation of the dorsal hippocampus on accumbens dopamine release was examined. Stimulation of the kindled hippocampus that produced stage 3 seizures evoked a brief increase in extracellular DA and DOPAC levels in the contralateral nucleus accumbens. In contrast, similar stimulation early in the development of kindling producing a stage 1 seizure did not evoke this increase.
Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, NY 11794-8790.
R E
RE
Strecker
M E
ME
Moneta
D000679:Amygdala / Q000502:physiology; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D004569:Electroencephalography; D005106:Exploratory Behavior / Q000502:physiology; D005110:Extracellular Space / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D017551:Microdialysis; D009043:Motor Activity / Q000502:physiology; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000378:metabolism
D004298:Dopamine