Genomic imprinting proposed as a surveillance mechanism for chromosome loss.
One consequence of genomic imprinting is that loss of the transcriptionally active chromosomal homologue causes a change in gene expression that might permit surveillance of chromosome-loss events. Possible selective advantages of such surveillance include protection against cancer and early elimination of monosomic and trisomic fetuses. Potential mechanisms for such surveillance are discussed.
Department of Genetics, University of Washington, Seattle 98195.
J H
JH
Thomas
D000818:Animals; D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics; D002872:Chromosome Deletion; D016678:Genome; D018392:Genomic Imprinting; D006801:Humans; D008957:Models, Genetic; D009006:Monosomy; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D014314:Trisomy; D009396:Wilms Tumor / Q000235:genetics