Clinical aspects of contact allergy to corticosteroids.
Because of their anti-inflammatory activity, corticosteroids generally mask the clinical signs of a contact dermatitis to a corticosteroid preparation. The lesions usually present as chronic dermatitis, and the patients mostly report not exacerbations but failures to respond to corticosteroid therapy. Moreover, masking also occurs with patch-test reactions obtained with corticosteroid preparations and the corticosteroid molecules themselves. These are important reasons why contact allergy to such preparations has frequently been missed in the past.
Dooms-Goossens
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Department of Dermatology, K.U. Leuven, Universitair Ziekenhuis, Belgium.
Degreef
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D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D006801:Humans
D000305:Adrenal Cortex Hormones