An in situ hybridization study on interleukin-1 beta mRNA induced by transient forebrain ischemia in the rat brain.
Expression of interleukin-1 beta (IL-1 beta) mRNA in the rat brain after transient forebrain ischemia was investigated by in situ hybridization histochemistry. Thirty min after the start of recirculation, IL-1 beta mRNA was induced in the several brain regions, including the olfactory bulb, cerebral cortex, hippocampus, striatum and thalamus where neuronal degeneration was reported to be observed after transient forebrain ischemia. The hybridization signals were observed both on the glial cells and around the vascular walls.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
K
K
Yabuuchi
M
M
Minami
S
S
Katsumata
A
A
Yamazaki
M
M
Satoh
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism; D002560:Cerebrovascular Circulation; D003342:Corpus Striatum / Q000378:metabolism; D004027:Diencephalon / Q000378:metabolism; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism; D017403:In Situ Hybridization; D007375:Interleukin-1 / Q000096:biosynthesis*; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D009410:Nerve Degeneration; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D009830:Olfactory Bulb / Q000378:metabolism; D009928:Organ Specificity; D015347:RNA Probes; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013687:Telencephalon / Q000378:metabolism; D013788:Thalamus / Q000378:metabolism
D007375:Interleukin-1; D015347:RNA Probes; D012333:RNA, Messenger