Effect of p-chloroamphetamine administration on monoamine metabolism in the rat nucleus accumbens and locomotor activity: studies with intracerebral dialysis in freely moving rats.
Changes in the level of dopamine (DA) and its metabolites [3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)] and serotonin (5-HT) and its metabolite [5-hydroxyindoleacetic acid (5-HIAA)] were determined sequentially in freely moving rats by using a brain dialysis method. The purpose of the study was to find the relationship between changes in the monoamine metabolism in the nucleus accumbens and locomotor activities following PCA administration. Subsequently it was found that locomotor activity significantly increased 1 and 2 h after PCA administration (2 mg/kg, i.p.) while the DA content in the dialysis fluid rose significantly after 1 and 2 h. On the other hand, the 5-HT level did not show significant changes. The DOPAC, HVA, and 5-HIAA levels were significantly reduced 1 to 6 h after PCA administration. It was suggested that the increase in locomotor activity caused by PCA administration is an expression of abnormal behavior caused by DA release from the nucleus accumbens.
Department of Psychiatry, Toyota Memorial Hospital, Aichi, Japan.
R
R
Sugita
K
K
Terada
Y
Y
Sekiya
Y
Y
Sawa
S
S
Nomura
T
T
Nakazawa
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009043:Motor Activity / Q000187:drug effects*; D009068:Movement / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D015306:Biogenic Monoamines; D010133:p-Chloroamphetamine