Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis.
Inflammation and the cytokines clearly affect the coagulation system. Less clear are the specific influences of the coagulation system on inflammation. In this chapter only some of the coagulation systems affected by the cytokines are discussed, and the influences on the fibrinolytic system, which is also downregulated by selected cytokines are not mentioned; see Schneiderman and Loskutoff (1991) for a brief review. The major focus is on possible models by which inflammation and coagulation are linked, and examples where in vitro studies have led to correct in vivo predictions and where the results remain ambiguous. Finally, this chapter is clearly a biased perspective with the primary emphasis on the components and pathways with which the author has personal experience.
Esmon
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Howard Hughes Medical Institute, Oklahoma Medical Research Foundation, Oklahoma City 73104.
D000818:Animals; D001779:Blood Coagulation Factors / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D002478:Cells, Cultured; D016207:Cytokines / Q000502:physiology* / Q000633:toxicity; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D008954:Models, Biological; D009369:Neoplasms / Q000097:blood / Q000150:complications; D010215:Papio; D011486:Protein C / Q000502:physiology; D012772:Shock, Septic / Q000097:blood / Q000150:complications; D018180:Thrombomodulin / Q000502:physiology; D013925:Thromboplastin / Q000502:physiology; D013927:Thrombosis / Q000139:chemically induced / Q000503:physiopathology*
D001779:Blood Coagulation Factors; D015815:Cell Adhesion Molecules; D016207:Cytokines; D011486:Protein C; D018180:Thrombomodulin; D013925:Thromboplastin