Structure of microcin C51, a new antibiotic with a broad spectrum of activity.
The structure of microcin C51, a new antibiotic produced by E. coli, has been determined. This antibiotic was shown to be a 1.18 kDa nucleotide peptide. It consists of a heptapeptide with formylmethionine as the N-terminus and a C-terminal asparagine linked with nebularin-5'-monophosphate through the three-methylene bridge. The OH-group of threonine is substituted. The peptide chain of microcin C51 synthesized on ribosomes is the longest among the known biologically active nucleotide peptides.
Metlitskaya
A Z
AZ
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow.
Katrukha
G S
GS
Shashkov
A S
AS
Zaitsev
D A
DA
Egorov
T A
TA
Khmel
I A
IA
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001430:Bacteriocins / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D011487:Protein Conformation
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C020411:microcin