FISH diagnosis of t(8;21) in a myelodysplasia secondary to Hodgkin lymphoma.
A t(8;21)(q22;q22) translocation without blood and bone marrow invasion by immature myeloid precursors was suspected in a conventional karyotype and confirmed by fluorescence in situ hybridization (FISH) with chromosome 8 and 21 painting in a patient previously treated for Hodgkin's lymphoma. Six weeks later, the diagnosis was confirmed by the onset of acute myeloid leukemia (AML) M2 with a t(8;21) in the bone marrow.
Laboratoire de Cytogénétique et de Génétique Oncologiques, URA 1158 CNRS, Villejuif, France.
A
A
Bernheim
A
A
Duverger
F
F
Fouquet
C
C
Bayle
O
O
Oberlin
D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic