Experimental saccular aneurysms. II. A new model in swine.
A new technique for surgical construction of experimental lateral saccular aneurysms on the common carotid artery of swine is described. It involves end-to-side suturing of an isolated segment of vein to an artery. During a short period of parent artery clamping, an elliptical arteriotomy is fashioned through the open-ended vein graft, the open end of which is subsequently tied and clamps are removed to form an aneurysmal vein pouch. The principal advantage of this technique is the short period of vascular clamping necessary to isolate a segment of the parent artery. This prevents severe endothelial injury and prolonged postoperative vasospasm, both of which may promote intra-aneurysmal thrombosis. Narrow- or wide-necked aneurysms can be created. Steps in the surgical construction of this model are detailed, and specific advantages of using swine are highlighted.
Guglielmi
G
G
Endovascular Therapy Service, University of California, Los Angeles Medical Center.
Ji
C
C
Massoud
T F
TF
Kurata
A
A
Lownie
S P
SP
Viñuela
F
F
Robert
J
J
D000818:Animals; D004195:Disease Models, Animal; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging*; D011859:Radiography; D013552:Swine