[Participation of neutrophils in the pathogenesis of allergic inflammation: inhibitory-protease index in assessing and predicting atopic illnesses].
Total trypsin-like (BAEE esterase), elastase-like (BOC esterase) and antitryptic activities were studied in blood serum of patients with atopic diseases. The elastase-like activity was increased in blood serum of all the patients examined during the acute period of the disease; the enzyme activation depended on the pathology severity and clinical picture manifestations. The increase in blood plasma total proteolytic activity correlated with reverse alteration in blood antitryptic potential. The data obtained suggest that activation of neutrophils occurred in atopic diseases, thus the rate of elastase-like activity in blood might be used as an objective pattern in examination of patients and in checking of treatment course. The developed inhibitory-protease index may serve also as a criterion in evaluation of the pathological state severity.
Puzhko
S G
SG
Dotsenko
V L
VL
Neshkova
E A
EA
Goriachkina
L A
LA
Nenasheva
N M
NM
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood* / Q000209:etiology; D006801:Humans; D006868:Hydrolysis; D006969:Hypersensitivity, Immediate; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D010196:Pancreatic Elastase / Q000097:blood; D011480:Protease Inhibitors / Q000097:blood
D011480:Protease Inhibitors; D010196:Pancreatic Elastase
Uchastie neĭtrofilov v patogeneze allergicheskogo vospaleniia: ingibitorno-proteaznyĭ indeks v otsenke i prognozirovanii atopicheskikh zabolevaniĭ.