Interleukin-8 and granulocyte-macrophage colony-stimulating factor secretion in hepatocellular carcinoma and viral chronic active hepatitis.
Interleukin-8 (IL-8) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are important mediators of inflammation and immune response in human disease. To demonstrate their importance in pathophysiological processes in liver disease, we measured the circulating levels of IL-8 and GM-CSF in patients with hepatocellular carcinoma (HCC) and chronic active hepatitis (CAH). IL-8 and GM-CSF levels in serum samples were determined with highly specific and sensitive enzyme-linked immunosorbent assays. IL-8 levels were more elevated in serum samples of patients with HCC and CAH associated with hepatitis C virus infection than HCC and CAH associated with hepatitis B virus infection. However, in all patients with autoimmune CAH and in some patients with HCC and CAH, GM-CSF levels were elevated over the baseline levels measured in all of the normals, but this difference was not statistically significant for any group. We conclude that IL-8 and GM-CSF are increased in some patients with liver diseases, and as such they may play a significant role in host defense and disease.
Department of Internal Medicine, (Gastroenterology Unit), King Saud University, College of Medicine, Saudi Arabia.
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al-Wabel
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al-Knawy
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Raziuddin
D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000378:metabolism*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood / Q000378:metabolism*; D006509:Hepatitis B / Q000097:blood / Q000378:metabolism*; D006526:Hepatitis C / Q000097:blood / Q000378:metabolism*; D006521:Hepatitis, Chronic / Q000097:blood / Q000378:metabolism*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood / Q000378:metabolism*; D008113:Liver Neoplasms / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D016209:Interleukin-8; D016178:Granulocyte-Macrophage Colony-Stimulating Factor