A possible relation between pressure loading and thickened leaflets of the aortic valve: a model simulation.
A much smaller percentage of thickened leaflets of the aortic valve have been found in the right or left coronary leaflet than in the noncoronary leaflet. This study investigated the pressure loading transferring to the leaflets of the aortic valve and their effects on the valvular thickening. A simple ascending aorta model was established, and a simulation was made. The pressure loading in the coronary and noncoronary leaflets then were estimated. The simulation results showed that 5.8% to 17.% percentage of pressure loading to the coronary leaflet may be decreased by the coronary perfusion in diastole. The coronary arteries play an important role on pressures in the sinuses of Valsalva. The smaller pressure loading transferring to the coronary leaflet than that to the noncoronary leaflet is one reasonable explanation related to the thickened leaflets of the aortic valve.
Young
S T
ST
National Yang-Ming University, Department of Surgery, Taipei, Taiwan, ROC.
Lin
S L
SL
D001011:Aorta / Q000503:physiopathology*; D001021:Aortic Valve / Q000473:pathology* / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D003331:Coronary Vessels / Q000503:physiopathology*; D003971:Diastole; D006801:Humans; D006984:Hypertrophy; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012850:Sinus of Valsalva / Q000503:physiopathology