Aerosol delivery of antibiotics to the lower airways of patients with cystic fibrosis.
Aerosolized tobramycin is well tolerated in children and adults with cystic fibrosis (CF). It represents a potential alternative to intravenous administration of antibiotics to control respiratory infection with Pseudomonas aeruginosa. Although its exact role in acute therapy for a CF exacerbation is not known, it has been shown to improve lung function and reduce the frequency of exacerbations in the chronic stable outpatient.
Fiel
S B
SB
Pulmonary and Critical Care Division, Medical College of Pennsylvania, Philadelphia.
D000280:Administration, Inhalation; D000336:Aerosols; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D016032:Randomized Controlled Trials as Topic; D014031:Tobramycin / Q000008:administration & dosage* / Q000627:therapeutic use*
D000336:Aerosols; D014031:Tobramycin