Effect of gugulipid on bioavailability of diltiazem and propranolol.
The effect of single oral dose of 1 gm gugulipid was studied on bioavailability of single oral dose of propranolol (40 mg) and diltiazem (60 mg) in 10 and 7 normal healthy male volunteers respectively. It was a randomised within group crossover study. Blood samples were collected at hourly intervals upto 8 hrs. Gugulipid significantly reduced (P < .01) peak plasma concentration (Cmax) and area under curve (AUC 0-8 hrs) of both the drugs in normal volunteers. Such interaction in patients receiving propanolol or diltiazem with gugulipid may lead to diminished efficacy or nonresponsiveness due to significant reduction in bioavailability.
Dalvi
S S
SS
Dept of Pharmacology, Seth GS Medical College, Parel, Bombay.
Nayak
V K
VK
Pohujani
S M
SM
Desai
N K
NK
Kshirsagar
N A
NA
Gupta
K C
KC
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D029744:Commiphora; D018592:Cross-Over Studies; D004110:Diltiazem / Q000493:pharmacokinetics*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D053149:Plant Gums; D011433:Propranolol / Q000493:pharmacokinetics*
D000960:Hypolipidemic Agents; D010936:Plant Extracts; D053149:Plant Gums; C018562:guggulu extract; D011433:Propranolol; D004110:Diltiazem