Mechanisms of inflammation and histopathology in inflammatory myopathy.
The term inflammatory myopathy describes a group of disorders characterized by mononuclear cell infiltration of muscle tissue. Abnormalities of cell-mediated immunity have been implicated repeatedly in the pathogenesis of these disorders. In recent years, considerable evidence supporting this view has been obtained, strongly suggesting a central role to T cells in the pathogenetic process. This article reviews the immunopathology and the cellular mechanisms involved in the pathogenesis of inflammatory myopathy.
Indiana University School of Medicine, Indianapolis.
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Kalovidouris
D006801:Humans; D007111:Immunity, Cellular; D007150:Immunohistochemistry; D016131:Lymphocyte Subsets / Q000276:immunology; D009132:Muscles / Q000276:immunology; D009220:Myositis / Q000276:immunology* / Q000473:pathology*