Antegrade/retrograde cardioplegia in arterial bypass grafting: metabolic randomized clinical trial.
The metabolic effects of combined antegrade/retrograde and antegrade cardioplegia on myocardial protection were evaluated and compared in 30 patients who underwent myocardial revascularization. All patients had three-vessel coronary artery disease, and the revascularization was done with exclusive use of arterial grafts (internal mammary artery, gastroepiploic artery). Myocardial protection consisted of oxygenated crystalloid cardioplegia, topical slushed ice, and moderate systemic hypothermia (34 degrees C). The patients were randomly separated into two groups: group A (n = 15), who received antegrade cardioplegia, and group A/R (n = 15), who received combined antegrade/retrograde cardioplegia. There was no significant difference between the two groups concerning preoperative and intraoperative data. After the first dose of cardioplegia, right ventricular temperature was significantly lower in group A/R (15 +/- 2 degrees versus 19 +/- 5 degrees C; p < 0.05), and there was no significant difference between the two groups in left ventricular temperature. Coronary sinus blood samples were obtained before bypass and 5, 10, and 15 minutes after reperfusion; there was no difference between the two groups concerning lactates, superoxide dismutase, and glutathione peroxidase. After reperfusion, malondialdehyde levels increased significantly in group A and there was no change in group A/R, with a significant difference between the two groups (at 10 minutes after reperfusion, 0.80 +/- 0.20 versus 0.53 +/- 0.16 mumol/L; p < 0.05). Right and left ventricular myocardial biopsies were performed before bypass and 15 minutes after reperfusion; there was no significant difference between the two groups concerning adenosine triphosphate and creatine phosphate myocardial concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Cardiovascular Surgery, Hôpital Cardiologique, Lyon, France.
O
O
Jegaden
A
A
Eker
P
P
Montagna
J
J
Ossette
C
C
Vial
J
J
Guidollet
P H
PH
Mikaeloff
D000255:Adenosine Triphosphate / Q000378:metabolism; D002314:Cardioplegic Solutions; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006324:Heart Arrest, Induced / Q000379:methods*; D006801:Humans; D007527:Isoenzymes; D007773:Lactates / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015425:Myocardial Reperfusion; D009204:Myocardial Revascularization; D009206:Myocardium / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood
D002314:Cardioplegic Solutions; D007527:Isoenzymes; D007773:Lactates; D010725:Phosphocreatine; D008315:Malondialdehyde; D000255:Adenosine Triphosphate; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D003402:Creatine Kinase