Plasma lecithin cholesterol acyl transferase activity, high density lipoprotein cholesterol and cholesterol ester in cholestasis.
Lecithin cholesterol acyl transferase activity, cholesterol ester and high density lipoprotein cholesterol concentrations were determined in Nigerian subjects suffering from cholestatic jaundice. Plasma lecithin cholesterol acyl transferase activities in all the study groups were similar. High density lipoprotein cholesterol and cholesterol ester were significantly increased in extrahepatic cholestasis while reduced levels were found in intrahepatic cholestasis. Enhanced cholesterol esterification may occur in extrahepatic cholestasis.
Agbedana
E O
EO
Department of Chemical Pathology, College of Medicine, University of Ibadan, Nigeria.
Taylor
G O
GO
Olubuyide
I O
IO
Ahaneku
J E
JE
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D001651:Cholestasis, Extrahepatic / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000209:etiology; D002780:Cholestasis, Intrahepatic / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000209:etiology; D002788:Cholesterol Esters / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D004951:Esterification; D006801:Humans; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*
D002788:Cholesterol Esters; D008076:Cholesterol, HDL; D007862:Phosphatidylcholine-Sterol O-Acyltransferase