Computational studies on the interaction between red cone and H1 horizontal cell.
We propose an equivalent circuit model of a discrete formulation to describe the interaction between the red cone syncytium and the H1 horizontal cell syncytium in lower vertebrate retinas. Analytical solutions of the model provide intuitive understandings of spatio-temporal properties of light-induced responses in reference to membrane impedance, strength of chemical synapse and coupling resistance connecting neighbouring cells. Physiologically plausible values of these parameters are estimated using the solutions. Quantitative studies are made to elucidate the function of (1) the negative feedback from the H1 horizontal cell to the red cone, and (2) the resistance increase of H1 horizontal cell coupling by dopamine.
Department of Mechanical Engineering, Nagoya Institute of Technology, Japan.
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Ohshima
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Yagi
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Funahashi
D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D017097:Electric Impedance; D005246:Feedback; D008433:Mathematics; D008564:Membrane Potentials / Q000187:drug effects; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology*; D010775:Photic Stimulation; D012160:Retina / Q000166:cytology* / Q000502:physiology; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology*; D013570:Synaptic Membranes / Q000502:physiology; D009435:Synaptic Transmission
D004298:Dopamine