Chlorpromazine and other psychoactive drug induced alterations of a membrane bound enzyme in rat brain.
Psychoactive drugs like chlorpromazine (CPZ), imipramine, lithium and amphetamine in one way or another affect behaviour. The drug responses are presumably mediated by inducing a change in the activity of membrane bound enzymes. CPZ is very potent in inhibiting the alkaline phosphatase activity in rat brain. The combined effect of CPZ with other drugs shows that CPZ and imipramine together inhibit the enzyme activity significantly greater than the individual inhibition either by CPZ or by imipramine alone. Effective inhibition of the alkaline phosphatase activity with a single drug or combined drugs may lead to a change in neuronal permeability through glucocorticoids thereby affecting mood.
Enzyme Chemistry Department, Indian Institute of Chemical Biology, Calcutta.
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D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors*; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002746:Chlorpromazine / Q000494:pharmacology*; D004347:Drug Interactions; D007099:Imipramine / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D008094:Lithium; D000661:Amphetamine; D000469:Alkaline Phosphatase; D007099:Imipramine; D002746:Chlorpromazine