Analytical inverse supercritical fluid extraction of polar pharmaceutical compounds from cream and ointment matrices.
It has been shown that inverse supercritical fluid extraction (SFE) can be used to analytically isolate a polar analyte from its matrix even at low concentrations (0.016%). Inverse SFE has been shown to be successful not only for the semi-solid Neosporin ointments, but also for the semi-liquid Neosporin creams as well. The technique has been shown to be superior to solid-phase extraction in both cases and affords the analytical chemist a quicker and safer method of sample preparation of analytes from both creams and ointments.
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061.
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Moore
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Taylor
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D009824:Ointments / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011112:Polymyxin B / Q000032:analysis; D013696:Temperature
D009824:Ointments; D004364:Pharmaceutical Preparations; D011112:Polymyxin B