T-cell activation. Transcriptional regulation in activated T cells.
Assembly of the activated T-cell transcription factor, NF-AT, from two different types of subunit is sensitive to immunosuppressive drugs and is a striking example of gene regulation by convergent intracellular signals.
Goodbourn
S
S
Department of Cellular and Molecular Sciences, St George's Hospital Medical School, University of London, UK.
D000818:Animals; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation; D016328:NF-kappa B / Q000378:metabolism; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D013601:T-Lymphocytes / Q000276:immunology*; D014157:Transcription Factors / Q000032:analysis* / Q000235:genetics; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D007166:Immunosuppressive Agents; D016328:NF-kappa B; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors; D004247:DNA