[The effect of lipid peroxidation on the lipid and phospholipid composition of mitochondrial membranes during thermal incubation].
Alterations in the content of lipids and phospholipids were studied in rat liver mitochondrial membranes after long-term heating at 37 degrees, pH 7.4, using FeSO4-ascorbate as inductors of lipid peroxidation. Under these conditions, activation of lipid peroxidation in mitochondrial membranes led to a marked increase in the rate of hydrolysis of phosphatidylethanolamine and lysophosphatidylethanolamine, to elevated synthesis of phosphatidylserine, sphingomyelin, phosphatidic and lysophosphatidic acids, diglycerides and cholesterol esters as well as to inhibit hydrolysis of phosphatidylcholine, cardiolipin and their lyso-derivatives.
Almatov
K T
KT
Mirtalipov
D T
DT
Musaev
Kh N
KhN
Dzhamalova
O T
OT
Azimov
D A
DA
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D005296:Ferrous Compounds / Q000378:metabolism; D006358:Hot Temperature; D006868:Hydrolysis; D007425:Intracellular Membranes / Q000378:metabolism*; D007700:Kinetics; D015227:Lipid Peroxidation; D008297:Male; D008563:Membrane Lipids / Q000096:biosynthesis / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010743:Phospholipids / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats
D005296:Ferrous Compounds; D008563:Membrane Lipids; D010743:Phospholipids; C020748:ferrous sulfate; D001205:Ascorbic Acid
Vliianie perekisnogo okisleniia lipidov na lipidnyĭ i fosfolipidnyĭ sostav membran mitokhondriĭ pri teplovoĭ inkubatsii.