Primary liver tumours in children.
An overview is presented of current management strategies in primary hepatic tumours in children. Recent advances include research in the genetic and molecular properties, especially of hepatoblastoma, the application of pre-operative chemotherapy, and the development of pre-surgical staging. Problem areas include management of relapse, chemotherapeutic drug resistance and multifocality. Hepatocellular carcinoma continues to have a much worse outcome than hepatoblastoma.
Paediatric Surgical Centre, Amsterdam, The Netherlands.
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Vos
D000293:Adolescent; D006528:Carcinoma, Hepatocellular; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D018197:Hepatoblastoma; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000628:therapy; D009367:Neoplasm Staging