Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. III. Structure elucidation of matlystatins A to F.
The structures of matlystatins, novel type IV collagenase inhibitors isolated from Actinomadura atramentaria, have been determined by a systematic application of homo- and heteronuclear 2D NMR and FAB-MS/MS techniques. Their structures were characterized by the presence of piperazic acid and hydroxamic acid moieties, structural motifs often seen in protease inhibitors.
Haruyama
H
H
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Ohkuma
Y
Y
Nagaki
H
H
Ogita
T
T
Tamaki
K
K
Kinoshita
T
T
D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D061965:Matrix Metalloproteinase Inhibitors; D008968:Molecular Conformation; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors