[Angioimmunoblastic lymphadenopathy. Apropos a case with unusual clinical manifestations and evolution to T-cell lymphoma].
We present the case of a 67-years-old patient which, after treatment with ciprofloxacin, developed fever, exanthema, arthralgias, polyadenopathies, hepatosplenomegaly, autoimmune hemolytic anemia, hypergammaglobulinemia and severe inversion of the CD4/CD8 ratio. Latter, he developed ischemic signs in several locations (splenic and cerebral infarcts), as well as polyneuropathy and inflammatory myopathy. The diagnosis of angioimmunoblastic lymphadenopathy was established through ganglionary biopsy. The patient improved initially with the administration of corticoids, but in a few months, he developed pleomorphic T lymphoma with quick fatal evolution. We discuss the rarity of some of the clinical and laboratory manifestations in this patient and we comment on the association of ciprofloxacin and the angioimmunoblastic lymphadenopathy, which has never been previously described in the international literature.
de la Torre Lima
F J
FJ
Servicio de Medicina Interna, H.U. Virgen Macarena, Sevilla.
Rubio Rubio
J M
JM
Garrachón Vallo
F
F
Pichardo Carballo
J J
JJ
Sánchez López
M P
MP
Zamora Madaria
E
E
D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002939:Ciprofloxacin / Q000009:adverse effects; D017809:Fatal Outcome; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008297:Male; D009132:Muscles / Q000473:pathology; D009333:Neck
D002939:Ciprofloxacin
Linfadenopatía angioinmunoblástica. A propósito de un caso con manifestaciones clínicas inusuales y evolución a linfoma T.