Evaluation of detomidine anesthetic combinations in the rabbit.
Detomidine, a potent alpha 2-adrenergic receptor agonist, was chosen for study alone and in combination with ketamine with or without diazepam. Four regimens were evaluated: detomidine (150 micrograms/kg of body weight) alone (D); ketamine (35 mg/kg) and detomidine (150 micrograms/kg) (KD); ketamine (35 mg/kg) and high-dose detomidine (300 micrograms/kg) (KDh); and ketamine (35 mg/kg), diazepam (1 mg/kg), and detomidine (150 micrograms/kg) (KDD). The same six rabbits were anesthetized with each combination at weekly intervals. Atropine (0.04 mg/kg) was administered as a preanesthetic 5 min prior to test substance administration. All agents were administered IM, except for diazepam, which was administered IV. Heart and respiratory rates, mean arterial blood pressure, and arterial blood gas tensions were measured. Pedal, palpebral, and righting reflexes also were evaluated. Cardiopulmonary depression, as indicated by decrease in heart and respiratory rates, blood pH, PO2, and increase in PCO2, was observed in all groups. With the exception of heart rate, detomidine used alone caused the least depression of these parameters. Reflexes were consistently lost only after KDh and KDD administrations. The pedal reflex, used as an index of anesthetic depth, was lost in response to KDh and KDD for 56.7 +/- 11.6 and 43.8 +/- 7.4 min, respectively (mean +/- SEM). Three of the six rabbits were anorectic after KDh administration. Necropsy and histologic evaluation revealed myocardial necrosis and fibrosis in five animals. Due to the inconsistent reflex loss in response to KD and D and inappetance associated with KDh, these combinations were not considered safe or reliable.(ABSTRACT TRUNCATED AT 250 WORDS)
Hurley
R J
RJ
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
Marini
R P
RP
Avison
D L
DL
Murphy
J C
JC
Olin
J M
JM
Lipman
N S
NS
D000700:Analgesics; D000758:Anesthesia / Q000379:methods / Q000662:veterinary*; D000818:Animals; D001285:Atropine / Q000008:administration & dosage; D002245:Carbon Dioxide / Q000097:blood; D003864:Depression, Chemical; D003975:Diazepam / Q000008:administration & dosage; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D007649:Ketamine / Q000008:administration & dosage; D008297:Male; D010100:Oxygen / Q000097:blood; D011817:Rabbits; D012018:Reflex / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013047:Specific Pathogen-Free Organisms
D000700:Analgesics; D007093:Imidazoles; D002245:Carbon Dioxide; D007649:Ketamine; D001285:Atropine; C041255:detomidine; D003975:Diazepam; D010100:Oxygen