Aconite induced myelo-optic neuropathy in a rabbit model.
Aconite is a common remedy of herb doctors and is widely used in the Far East. Clinical aspects of the visual disturbance produced by this drug have been described, but little is known about its pathology. Tinctura aconiti (0.6 mg of total alkaloid/kg 2x) was administered intraperitoneally in rabbits to evaluate its toxic effects on the visual system. The alteration in the visual evoked potential following aconite injection consisted of a delay in the onset and peak latency. Histopathologically, there were damages to the myelin sheath of the visual pathway, spinal cord and peripheral nerves. These findings suggest that aconite may cause primarily myelo-optic neuropathy.
Department of Biochemistry, Hyosung University College of Pharmacy, Korea.
K D
KD
Suk
K C
KC
Yoon
J P
JP
Shin
S H
SH
Kim
D031841:Aconitum / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D009186:Myelin Sheath / Q000187:drug effects* / Q000648:ultrastructure; D009900:Optic Nerve / Q000187:drug effects* / Q000648:ultrastructure; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits; D013116:Spinal Cord / Q000187:drug effects* / Q000648:ultrastructure