Immunomodulatory properties of 9-(2-phosphonomethoxyethyl)-adenine (PMEA).
PMEA was found to influence the immune system of the mouse and rat in vivo in different ways. PMEA administered after injection of parental splenocytes to F1 recipients reduced the development of local graft-versus-host reaction (GVHR). However, PMEA treatment of donors of splenocytes had no influence on GVHR. Modifications in the immune system triggered by PMEA were confirmed in the rat model by evaluation of subsets of white blood cells isolated from peripheral blood by a set of monoclonal antibodies. Enhanced formation of nitric oxide (NO) was found in both unconditioned and LPS-stimulated macrophage cultures on day 14 of the drug treatment of rats.
Department of Biology, First Faculty of Medicine, Charles University, Praha.
B
B
Otová
Z
Z
Zídek
A
A
Holý
I
I
Votruba
D
D
Franková
D000225:Adenine / Q000031:analogs & derivatives* / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000911:Antibodies, Monoclonal; D002478:Cells, Cultured; D006087:Graft vs Host Reaction; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D063065:Organophosphonates
D000276:Adjuvants, Immunologic; D000911:Antibodies, Monoclonal; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine