The arterial wall and the atherosclerotic lesion.
The role of the lipid-rich core region in atherogenesis is beginning to be understood, from its inception in early lesions to its catastrophic effects in promoting plaque rupture in late lesions. Besides the lipid-rich core, recent studies on human and animal atherosclerosis have drawn attention to atherogenic lipoproteins larger than LDL, unesterified cholesterol in lesions, apolipoprotein E as an antiatherogenic factor, macrophages as atherogenic effector cells, and unexpectedly slow rates of smooth muscle cell proliferation.
Department of Medicine, Duke University Medical Center, Durham, North Carolina.
J R
JR
Guyton
D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism; D001158:Arteries / Q000473:pathology*; D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002455:Cell Division; D002784:Cholesterol / Q000378:metabolism; D004032:Diet; D004195:Disease Models, Animal; D006801:Humans; D050356:Lipid Metabolism; D051379:Mice; D008822:Mice, Transgenic; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology*; D010084:Oxidation-Reduction
D001057:Apolipoproteins E; D002784:Cholesterol