Suppression of sucrose intake by continuous near-celiac and intravenous cholecystokinin infusions in rats.
We compared suppression of intake of 30% sucrose produced by continuous aortal (near celiac) and intravenous infusions of cholecystokinin octapeptide (CCK-8). Adult, male Sprague-Dawley rats received 21-min infusions of saline or 100-1,600 ng CCK-8. Sucrose was available for 20 min, beginning 1 min after onset of infusions. Significant reductions in intake were produced by near-celiac infusions of 400, 800, and 1,600 ng CCK-8, but only the two highest doses affected intake when infused intravenously. In a second experiment, which replicated previous observations, near-celiac bolus infusions of 70 ng CCK-8 significantly reduced sucrose intake but intravenous infusions did not. Behavioral observations indicated that although bolus infusions produced immediate disruption of feeding, suggesting an aversive effect, effects of continuous CCK-8 infusions on temporal intake patterns were consistent with enhancement of satiety. These data provide further evidence that CCK-8 acts on a site within the upper gastrointestinal tract to produce satiety.
Department of Psychology, University of Alabama at Birmingham 35294.
J E
JE
Cox
G S
GS
Perdue
W J
WJ
Tyler
D000704:Analysis of Variance; D000818:Animals; D002445:Celiac Artery; D004040:Dietary Carbohydrates; D004305:Dose-Response Relationship, Drug; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012527:Satiation / Q000187:drug effects*; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology*; D013395:Sucrose
D004040:Dietary Carbohydrates; D013395:Sucrose; D012844:Sincalide