[Nuclear magnetic resonance relaxation times for human lung cancer and lung tissues].
We investigated the nuclear magnetic resonance (NMR) relaxation times, T1 and T2, for lung cancer tissue, and other samples of lung tissue obtained from surgical specimens. The samples were nine squamous cell carcinoma, five necrotic squamous cell carcinoma, 15 adenocarcinoma, two benign mesothelioma, and 13 fibrotic lungs. The relaxation times were measured with a 90 MHz NMR spectrometer and the results were correlated with histological changes. The values of T1 and T2 for squamous cell carcinoma and mesothelioma were significantly longer than those of adenocarcinoma and fibrotic lung tissue. There were no significant differences in values of T1 and T2 between adenocarcinoma and lung tissue. The values of T1 and T2 for benign mesothelioma were similar to those of squamous cell carcinoma, which suggested that increases in T1 and T2 are not specific to malignant tissues.
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Y
Y
Matsuura
S
S
Shioya
D
D
Kurita
T
T
Ohta
S
S
Suda
M
M
Haida
M
M
Fukuzaki
Y
Y
Ohta
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy; D008654:Mesothelioma / Q000175:diagnosis / Q000473:pathology