KK mouse.
The KK mouse strain shows inherently glucose intolerance and insulin resistance. When KK mice become obese by aging, dietary means or other ways, such a chemical diabetic state is changed to overt diabetic state associated with frank hyperglycemia and glucosuria. Therefore, the KK mouse is a good model for investigating a process of expression of obesity-associated diabetes.
Ikeda
H
H
Pharmaceutical Research Laboratories II, Takeda Chemical Ind., Ltd., Osaka, Japan.
D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics; D004195:Disease Models, Animal; D007333:Insulin Resistance / Q000235:genetics*; D007515:Islets of Langerhans / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009765:Obesity