Efficacy of oral amphotericin B in AIDS patients with thrush clinically resistant to fluconazole.
Reports of thrush clinically refractory to azoles in AIDS patients are increasing with the more widespread use of these agents. We studied our own oral preparation of amphotericin B in the treatment of two AIDS patients who developed oral thrush due to Candida glabrata after prolonged fluconazole use. Improvement occurred in both in less than 1 week, with eventual clearing and absence of side effects. Oral amphotericin B may have advantages over alternatives for this increasing problem.
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128-2699.
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Dewsnup
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Stevens
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000284:Administration, Oral; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D002180:Candidiasis, Oral / Q000150:complications / Q000188:drug therapy*; D003362:Cost-Benefit Analysis; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D016896:Treatment Outcome
D000666:Amphotericin B; D015725:Fluconazole