The role of native apolipoprotein B-containing lipoproteins in atherosclerosis: cellular mechanisms.
Apolipoprotein B-containing lipoproteins play a central role in the pathogenesis of atherosclerosis. The processes that determine the atherogenicity of these lipoproteins, however, remain unclear. A new development that involves the interactions of lipoproteins, enzymes, apolipoproteins, and cell-surface heparan sulphate may explain, at least in part, the enhanced atherogenicity of these lipoproteins. In addition, the development of specific transgenic apolipoproteins, and apolipoprotein-deficient mice models that develop atherosclerosis, provide new tools for studies on the role of native apolipoprotein-B containing lipoproteins in atheroma formation.
Sehayek
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Institute of Lipid and Atherosclerosis Research, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Eisenberg
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D000818:Animals; D001055:Apolipoproteins B / Q000502:physiology*; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002914:Chylomicrons / Q000502:physiology; D006801:Humans; D008074:Lipoproteins / Q000502:physiology; D053419:Lipoproteins, IDL; D008077:Lipoproteins, LDL / Q000502:physiology; D008079:Lipoproteins, VLDL / Q000502:physiology
D001055:Apolipoproteins B; D002914:Chylomicrons; D008074:Lipoproteins; D053419:Lipoproteins, IDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL