Synthesis and in vitro cytotoxic activity of aza- and diazaanthraquinone derivatives.
Some 1,4-dihydro aza- and 1,4-dihydro diazaanthraquinone derivatives have been synthesized and submitted to in vitro cytotoxicity tests towards L 1210, MDA-MB 231 and PC3 cell lines. Some of the new substances showed significant activity.
Laboratoire de Chimie Organique, Institut des Sciences Pharmaceutiques et Biologiques, Lyon, France.
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P
Nebois
S C
SC
do Nascimento
M
M
Boitard
M H
MH
Bartoli
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H
Fillion
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D014407:Tumor Cells, Cultured
D000880:Anthraquinones; D000970:Antineoplastic Agents