[Difficulties in diagnosing atypical primary HIV-1 infection: report of a case].
Several cases of primary HIV-1 infection are not identified, either because the diagnosis is not suspected or because they test negative for HIV-1 antibody. This work presents an uncommon case of primary HIV-1 infection in an young parenteral drug abuser man, who presented symptoms of acute hepatitis. During the initial acute phase the serum sample of the patient tested negative for the presence of antibodies against several viruses, including HIV-1. Nevertheless, the diagnosis of primary HIV-1 infection was suspected by using an alternative method for "in vitro" induced antibody production (IVIAP), and confirmed by p24 antigen serum positivity and seroconversion in serial plasma samples of the patient. The authors suggest the use of the IVIAP and others complementary assays to help the diagnosis of acute HIV-1 infection in persons at high risk conditions.
Casseb
J S
JS
Médico Infectologista, Instituto de Infectologia Emílio Ribas, São Paulo, SP, Brasil.
Caterino-de-Araujo
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis*; D000208:Acute Disease; D000328:Adult; D003937:Diagnosis, Differential; D015483:HIV Antibodies / Q000276:immunology; D015488:HIV Antigens / Q000276:immunology; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male
D015483:HIV Antibodies; D015488:HIV Antigens
Dificuldades no diagnóstico de infecção primária atípica por HIV-1. Relato de um caso.