Biochemical analysis of breast cyst fluid as a possible predictor of breast carcinoma development.
The occurrence of breast cancer in patients with gross cystic disease is 2-5 times higher as compared to control group of women. During 3 years, 183 cyst fluid samples were analyzed in 129 females, in 30 patients of them the samples were analysed repeatedly. The distribution of the Na+/K+ ratio, considered as the measure of cancer risk, was found to be bimodal. In repeated analyses the type I cyst fluid markedly predominated (Na+/K+ < or = 4.0). A direct dependence on this ratio was found in the concentration of glucose, albumin, carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and its specific form, TPS; an indirect dependence was found for the level of uric acid, phosphates, alkaline phosphatase (ALP) and alpha-amylase (AMS). The predominance of apocrine metaplasia cells released into the cyst fluid is characteristic of type I cysts. A definitive assessment of significance of these parameters will be enabled by a long-term follow-up of the disease in the respective patients.
Masaryk Memorial Cancer Institute, Brno, Czech Republic.
M
M
Simíøcková
L
L
Pecen
K
K
Eben
M
M
Nekulová
I
I
Vermousek
P
P
Stratil
A
A
Rejthar
M
M
Cernoch
B
B
Lang
J
J
Sakalová
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000209:etiology*; D005122:Exudates and Transudates / Q000737:chemistry*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000150:complications* / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010783:Photometry; D011188:Potassium / Q000032:analysis; D011237:Predictive Value of Tests; D012307:Risk Factors; D012964:Sodium / Q000032:analysis
D014408:Biomarkers, Tumor; D012964:Sodium; D011188:Potassium