Hyperestrogenism induced by menotropins alone or in conjunction with luprolide acetate in in vitro fertilization cycles: the impact on hemostasis.
OBJECTIVE
To evaluate coagulation parameters during IVF cycles with elevated E2.


METHODS
Prospective clinical study.


METHODS
Human volunteers in an IVF clinic.


METHODS
Infertile women undergoing IVF procedures.


METHODS
Coagulation factors were measured in blood along with E2 and P after singular hMG or leuprolide acetate (LA) plus hMG up to 14 days after hCG.


METHODS
Plasma coagulation factors.


RESULTS
Some coagulation factors were statistically but not clinically elevated after LA-hMG-induced hyperestrogenism. For the most part, this was not correlated with E2.


CONCLUSIONS
This study suggests that endogenous E2 increases due to fertility drugs cause a molecular activation of some coagulation factors, which do not result in an increased thrombosis.
Lox
C
C
Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, Lubbock.
Cañez
M
M
DeLeon
F
F
Dorsett
J
J
Prien
S
S
D000328:Adult; D000704:Analysis of Variance; D001779:Blood Coagulation Factors / Q000032:analysis*; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D016729:Leuprolide / Q000627:therapeutic use*; D008596:Menotropins / Q000627:therapeutic use*; D010314:Partial Thromboplastin Time; D011374:Progesterone / Q000097:blood; D011486:Protein C / Q000032:analysis; D011517:Prothrombin Time
D001779:Blood Coagulation Factors; D011486:Protein C; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins; D005340:Fibrinogen; D016729:Leuprolide