Mapping the human genome.
The haploid human genome contains approximately 70,000 different genes in its 3200 megabases of chromosomal DNA. High resolution maps of all chromosomes are urgently required both for functional analysis of the genome as a whole and for the identification and characterization of its constituent gene sequences. To this end, a variety of markers including genes, anonymous DNA segments and sequence-tagged sites are being recruited as single copy landmarks which can be readily incorporated into both genetic and physical maps. Current progress toward the generation of physical, genetic and cytogenetic maps of human chromosomes and their integration is reviewed.
Cooper
D N
DN
Charter Molecular Genetics Laboratory, Thrombosis Research Institute, London, UK.
D002874:Chromosome Mapping; D005819:Genetic Markers; D015894:Genome, Human; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D014158:Transcription, Genetic
D005819:Genetic Markers