[The CD2, CD4 and CD8 mRNA expression of T lymphocytes in patients with acromegaly and hyperprolactinemia].
The CD2, CD4 and CD8 mRNA expression of human peripheral blood lymphocytes (HPBL) from 49 female patients with acromegaly and hyperprolactinemia and 15 healthy women were studied by dot blotting assay using corresponding CD2, CD4 and CD8 antisense RNA probes. It was found that CD2 mRNA expression increased in women with growth hormone over-expression and the ratio of CD4 and CD8 mRNA declined significantly in the women with prolactin over-expression. These suggested that the mRNA expression of these cluster differentiation antigens in peripheral T lymphocytes was affected by the pituitary hormones. The significance of these findings relevant to the study of the neuroendocrine and immune network was discussed.
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
J X
JX
Liu
D X
DX
Zheng
Z S
ZS
Zhang
D000172:Acromegaly / Q000235:genetics / Q000276:immunology*; D000328:Adult; D000368:Aged; D018801:CD2 Antigens / Q000235:genetics*; D015704:CD4 Antigens / Q000235:genetics*; D016827:CD8 Antigens / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D006966:Hyperprolactinemia / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology
D018801:CD2 Antigens; D015704:CD4 Antigens; D016827:CD8 Antigens; D012333:RNA, Messenger