Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse.
Activation and proliferation of microglia are common cellular hallmarks in many different pathological processes of the central nervous system. Although a number of colony-stimulating factors enhance microglial proliferation in vitro, little is known about the endogenous mitogens. In the present study we show a strong and selective inhibition of microglial proliferation in the facial nucleus of osteopetrotic (op/op) mice, with a genetic deficiency in biologically active macrophage colony-stimulating factor (MCSF). Posttraumatic activation of adjacent axotomized neurons and reactive astrocytes was not affected, emphasizing the specificity of MCSF as a microglial growth factor.
Raivich
G
G
Department of Neuromorphology, Max Planck Institute for Psychiatry, Martinsried, Germany.
Moreno-Flores
M T
MT
Möller
J C
JC
Kreutzberg
G W
GW
D000818:Animals; D002455:Cell Division / Q000502:physiology; D016173:Macrophage Colony-Stimulating Factor / Q000172:deficiency*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D017628:Microglia / Q000166:cytology*; D008957:Models, Genetic; D010022:Osteopetrosis / Q000235:genetics / Q000473:pathology*; D014947:Wounds and Injuries / Q000473:pathology*
D016173:Macrophage Colony-Stimulating Factor