Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.
Alzheimer's disease results in the appearance of cytoskeletal disorders yielding pathological structures such a neurofibrillary tangles or dystrophic neurites. It has been previously described that the microtubule-associated protein, tau, modified by phosphorylation in serines adjacent to prolines, is a major component of these structures. Here, we show that another microtubule associated protein, MAP1B, aberrantly phosphorylated by a proline-dependent protein kinase, is a component of these previously mentioned structures. Thus, a possible common phosphorylation of axonal MAPs such as tau or MAP1B may correlate with their association with those aberrant cytoskeletal structures present in AD.
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Fac. de Ciencias, Univ. Autónoma de Madrid, Spain.
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L
Ulloa
E
E
Montejo de Garcini
P
P
Gómez-Ramos
M A
MA
Morán
J
J
Avila
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000378:metabolism; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D005333:Fetus; D006801:Humans; D008297:Male; D016253:Microscopy, Immunoelectron; D008869:Microtubule-Associated Proteins / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism; D010750:Phosphoproteins / Q000032:analysis / Q000378:metabolism; D010766:Phosphorylation; D038461:Proline-Directed Protein Kinases; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051381:Rats; D012016:Reference Values; D016875:tau Proteins / Q000378:metabolism
D008869:Microtubule-Associated Proteins; D010750:Phosphoproteins; C085284:microtubule-associated protein 1B; D016875:tau Proteins; D038461:Proline-Directed Protein Kinases; D017346:Protein Serine-Threonine Kinases