The elimination peculiarities of perfluorocarbon emulsions stabilized with egg yolk phospholipid.
In order to examine the elimination rate of Perfluorodecalin (FDC) emulsions stabilized with different emulsifiers--yolk phospholipid (EYP) and procsanol P-268 (analog of Pluronic F-68)--we performed controlled trials on excretion of FDC in exhaled air, elimination from blood and accumulation in the liver. Adult Wistar rats were injected intravenously with FDC emulsions stabilized with different emulsifiers at a dose of 11.5 g FDC per kg body weight. The concentration of FDC in blood, exhaled air and liver tissue was examined by means of the gas chromatography method. The circulation time in blood for the emulsion stabilized with EYP was much longer comparatively to the emulsion containing the synthetic emulsifier procsanol P-268. The injection of EYP dispersions prolonged the circulation time of lipid-stabilised FDC emulsions. The rate of PFC elimination in exhaled air from such an emulsion and the rate of its accumulation in liver during the initial period after injection are reduced compared to the procsanol-stabilized emulsion. These data are interpreted as the result of a reduction of phagocytic activity of blood monocytes toward the lipid-coated particles of the emulsion. The circulation time of PFC emulsion can be prolonged by using lipid emulsifier and additional injections of EYP dispersion.
Department of Medical Biotechnology, Research Institute of Experimental and Clinical Immunology, Moscow, Russia.
T K
TK
Putyatina
U D
UD
Aprosin
N I
NI
Afonin
D000818:Animals; D001802:Blood Substitutes / Q000493:pharmacokinetics*; D004355:Drug Stability; D004530:Egg Yolk / Q000737:chemistry*; D004655:Emulsions; D004852:Epoxy Compounds; D005079:Excipients; D005466:Fluorocarbons / Q000493:pharmacokinetics*; D010743:Phospholipids / Q000737:chemistry*; D011060:Poloxalene / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar
D001802:Blood Substitutes; D004655:Emulsions; D004852:Epoxy Compounds; D005079:Excipients; D005466:Fluorocarbons; D010743:Phospholipids; C092023:procsanol P-268; C008805:perfluorodecalin; D011060:Poloxalene