Physical mapping of 3 candidate tumor suppressor genes relative to Beckwith-Wiedemann syndrome associated chromosomal breakpoints at 11p15.3.
A physical map encompassing the 3 Mb region containing the breakpoints of two Beckwith-Wiedemann Syndrome patients at chromosome band 11p15.3 is presented. The candidate tumor suppressor genes WEE1, ST5, and rhombotin, are positioned on this map relative to these Beckwith-Wiedemann syndrome translocation and inversion breakpoints.
Institute of Human Genetics, University of Amsterdam, The Netherlands.
E
E
Redeker
M
M
Alders
J M
JM
Hoovers
C W
CW
Richard
A
A
Westerveld
M
M
Mannens
D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics*; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence
D015342:DNA Probes