[The antithrombotic and thrombolytic activity of a plasminogen activator isolated from a monolayer cell culture].
Plasminogen activator has been isolated from the culture of pig kidney cells by gel-filtration on Sephadex G-75. The plasminogen activator (181.9 MU/200 g body weight) protected the animals against thrombosis hazard in case of provocation by thromboplastin and exerted a thrombolytic effect in case of thrombus appearance.
L A
LA
Liapina
V E
VE
Pastorova
G A
GA
Koval'chuk
M I
MI
Leĭkina
G A
GA
Leĭkina
I A
IA
Poliakova
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D005342:Fibrinolysis / Q000187:drug effects; D007601:Jugular Veins; D007668:Kidney; D008297:Male; D010960:Plasminogen Activators / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013552:Swine; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy
D010960:Plasminogen Activators
Antitromboticheskaia i tromboliticheskaia aktivnost' aktivatora plazminogena, vydelennogo iz kletok monosloĭnoĭ kul'tury.