[Protective effect of putrescine on oleic acid-induced respiratory distress syndrome (RDS)].
The effect of putrescine on oleic acid-induced RDS were studied in rat, it was found that preadministration of putrescine to rat with RDS significantly improved its hypoxemia, pulmonary edema and histologic injury; inhibited the leakage of protein from plasma; lowered increase of pulmonary lipid peroxidation products (malondialdehde, MDA). The result suggests that putrescine could have significant potential for clinical treatment of acute pulmonary injury.
Zhao
D
D
Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University.
Liu
P H
PH
Fu
A H
AH
D000818:Animals; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D019301:Oleic Acid; D009829:Oleic Acids; D009929:Organ Size / Q000187:drug effects; D011700:Putrescine / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000517:prevention & control*
D009829:Oleic Acids; D019301:Oleic Acid; D008315:Malondialdehyde; D011700:Putrescine