Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study.
Membrane phospholipid metabolism was studied with 31P magnetic resonance spectroscopy in the left dorsal prefrontal cortex of 19 male, medicated, schizophrenic patients and compared to 18 normal male controls matched in age, education and parental education level. The schizophrenic patients had significantly decreased phosphomonoester levels (PMEs, metabolites predominantly involved in the synthesis of membrane phospholipids). Phosphodiester levels (PDEs, breakdown products of membrane phospholipids) were not statistically different in schizophrenic patients compared to controls. However, a significant increase in the PDE levels was observed in the newly diagnosed patient subgroup. This observed pattern of the PMEs and PDEs would be consistent with the presence of an abnormal neurodevelopment early in the illness of schizophrenia.
Department of Nuclear Medicine and Magnetic Resonance, St. Joseph's Health Centre, London, Ontario, Canada.
J A
JA
Stanley
P C
PC
Williamson
D J
DJ
Drost
T J
TJ
Carr
R J
RJ
Rylett
S
S
Morrison-Stewart
R T
RT
Thompson
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013570:Synaptic Membranes / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
D008563:Membrane Lipids; D010743:Phospholipids