[Significance of cutaneous microangiopathy for the pathogenesis of dermatitis in venous congestion due to chronic venous insufficiency].
Skin damage due to chronic venous insufficiency is preceded by severe microangiopathy of skin. With increasing clinical symptoms like edema, hyperpigmentation, induration, ulcer and atrophy blanche number of nutritive capillaries and transcutaneous oxygen-tension decreases, transcapillary, and interstitial leakage increases and cutaneous vascular reserve disappears. These congruent results were found by means of capillaroscopy, fluorescence-videomicroscopy, transcutaneously measured oxygen partial pressure and Laser Doppler Fluxmetry. Most of capillaries are elongated and tortuous, especially in ulcer stage they look glomerular. Compared to pin-shaped capillaries glomerular capillaries contribute less to nutrition because of functional AV-shunts. As dilated capillaries are already seen in skin areas without any trophic skin changes, cutaneous microangiopathy seems to be first consequence of venous hemodynamic disturbances which then is followed by skin disease. As severe microangiopathy still remains after healing of ulcer, it explains frequent recurrencies.
Universitäts-Hautklinik Tübingen, Deutschland.
M
M
Jünger
U
U
Hahn
S
S
Bort
T
T
Klyscz
M
M
Hahn
G
G
Rassner
D001783:Blood Flow Velocity / Q000502:physiology; D002196:Capillaries / Q000473:pathology; D002199:Capillary Permeability / Q000502:physiology; D003872:Dermatitis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008209:Lymphedema / Q000473:pathology / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology; D011186:Postphlebitic Syndrome / Q000473:pathology / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply*; D014647:Varicose Ulcer / Q000473:pathology / Q000503:physiopathology; D014689:Venous Insufficiency / Q000473:pathology / Q000503:physiopathology*
Bedeutung der kutanen Mikroangiopathie für die Entstehung von Stauungsdermatosen bei chronischer Veneninsuffizienz (CVI).