Imipramine reduces the local inflammatory response to carrageenin.
Imipramine was administered chronically to LEW/N, outbred and F344/N rats which were then exposed to the aseptic irritant carrageenin in order to determine whether the decreased hypothalamic expression of CRH m-RNA previously shown to be associated with imipramine affects peripheral immune processes. Both LEW/N and outbred but not F344/N rats had vigorous inflammatory responses to carrageenin, and imipramine was associated with significant decreases in the local cellular inflammatory response to carrageenin. Imipramine was also associated with changes in the expression of peripheral blood cell MHC class II expression in LEW/N and outbred rats. These results suggest that at doses comparable to those used clinically imipramine has significant effects on response to an inflammatory stimulus.
Michelson
D
D
Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892.
Misiewicz-Poltorak
B
B
Raybourne
R B
RB
Gold
P W
PW
Sternberg
E M
EM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D005122:Exudates and Transudates / Q000187:drug effects / Q000276:immunology; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D007099:Imipramine / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D008285:Major Histocompatibility Complex / Q000276:immunology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013045:Species Specificity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D007099:Imipramine