[High dosage intravenous gamma globulin therapy in juvenile dermatomyositis].
In the last few years high-dose intravenous therapy with gammaglobulin in juvenile dermatomyositis with steroid resistant myopathy has been discussed as an alternative to cytostatic therapy. The 12-year-old Filipinogirl suffered from dermatomyositis with pronounced weakness of the limbs and masticatory muscles; creatinine-kinase was increased 22-fold. After 5 weeks of therapy with prednisolone (1.5 mg/kg body/weight/daily), the creatinine kinase decreased to sixfold of its standard value; the muscular weakness, however, progressed to almost complete paralysis of the scapular abductors and rotators and the coxofemoral flectors and rotators. Additional therapy with gammaglobulin at a dose of 1 g/kg body weight on two consecutive days at 4-week intervals led to complete restoration of muscular strength, normalization of muscle enzymes, and stabilization of these results after 12 courses of gammaglobulin and discontinuation of the steroid medication after 8 courses. This observation suggests that high-dose intravenous application of gammaglobulin represents an efficient therapy with minimal side effects in steroid-resistant juvenile dermatomyositis.
Hautklinik, Klinikum Minden.
K
K
Schmidt
M
M
Westenberger-Treumann
R
R
Stadler
D001706:Biopsy; D002648:Child; D003131:Combined Modality Therapy; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000473:pathology / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D009460:Neurologic Examination / Q000187:drug effects; D011239:Prednisolone / Q000008:administration & dosage; D012867:Skin / Q000473:pathology
D011239:Prednisolone; D003402:Creatine Kinase
Hochdosierte intravenöse Gammaglobulin-Therapie bei juveniler Dermatomyositis.