Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619.
NS 1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 microM, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.
A J
AJ
Sellers
M L
ML
Ashford
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D002478:Cells, Cultured; D010455:Peptides / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects*
D001562:Benzimidazoles; D010455:Peptides; D015221:Potassium Channels; C086491:NS 1619; C064719:iberiotoxin; D002118:Calcium