Propentofylline enhances the formation of long-term potentiation in guinea pig hippocampal slices.
The postsynaptic field potential (population spike; PS) was recorded in the CA1 area of guinea pig hippocampal slices in response to electrical stimulation of Schaffer's collateral. After tetanic stimulation (100 Hz for 1 s) to Schaffer's collateral, the PS amplitude increased to 127.9 +/- 7.7% (mean +/- S.E.M.) of the original level at 20 min and 140.1 +/- 7.7% at 60 min, and formed long-term potentiation (LTP). After application of 10 nM propentofylline, a synthetic xanthine derivative, which did not enhance the amplitude of the PS evoked by the test stimulus, the tetanic stimulation increased the amplitude to 160.3 +/- 3.8% at 20 min and 173.3 +/- 4.3% at 60 min. Thus, propentofylline enhances the formation of LTP in hippocampal slices.
Department of Physiology, School of Medicine, Kobe University, Japan.
Y
Y
Yamada
H
H
Nakamura
Y
Y
Okada
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000241:Adenosine / Q000378:metabolism; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D009435:Synaptic Transmission / Q000187:drug effects; D014970:Xanthines / Q000494:pharmacology*
D016194:Receptors, N-Methyl-D-Aspartate; D014970:Xanthines; C032114:propentofylline; D015763:2-Amino-5-phosphonovalerate; D000241:Adenosine