Gene targeting and synaptic plasticity.
Gene targeting is revealing new molecular functions by creating very specific developmental, physiological and behavioral perturbations, and providing new insights into biochemical pathways underlying synaptic plasticity. Recent studies of mice carrying mutations in genes thought to be involved in modulating synaptic transmission have been subject to integrated biochemical, physiological and behavioral analyses.
Center for Genome Research, University of Edinburgh, UK.
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Grant
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D018390:Gene Targeting; D006801:Humans; D007858:Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout / Q000523:psychology; D008959:Models, Neurological; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000502:physiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D011494:Protein Kinases / Q000235:genetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics; D015290:Second Messenger Systems; D013569:Synapses / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism
D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate; D011494:Protein Kinases