Soluble transferrin receptor following bone marrow transplantation from donors heterozygous for beta thalassemia.
This study analyzes the serum transferrin receptor (sTfR) levels in a series of 184 ex-thalassemic patients with a follow-up of 1 to 9 years after bone marrow transplantation (BMT) for homozygous beta thalassemia. A significant inverse correlation between sTfR and Hb levels was observed (r = -0.36, p < 0.001). Patients who received the marrow from an HLA-identical sibling donor heterozygous for beta thalassemia displayed significantly higher levels of sTfR than patients transplanted from a normal sibling donor (p < 0.001). A cut-off value of 2600 ng/mL of sTfR was established. Only 3 out of 56 (5%) patients who received the marrow from a normal sibling, reached a sTfR value above the cut-off level, while 64 out of 128 (50%) patients transplanted from a heterozygous sibling donor showed sTfR values > 2600 ng/mL (p < 0.001). These results suggest that the level of sTfR helps to identify ex-thalassemic patients with enhanced or normal erythropoietic activity among those transplanted from HLA-identical sibling donors heterozygous for beta thalassemia. The physiologic and clinical significance of different patterns of sTfR levels in ex-thalassemic patients with beta thalassemia trait deserves to be investigated.
Centis
F
F
Division of Hematology & BMT Center, Hospital of Pesaro, Italy.
Delfini
C
C
Agostinelli
F
F
Tonucci
P
P
Gaziev
J
J
Annibali
M
M
Lucarelli
G
G
D016026:Bone Marrow Transplantation; D005500:Follow-Up Studies; D006579:Heterozygote; D006801:Humans; D011990:Receptors, Transferrin / Q000378:metabolism*; D012995:Solubility; D014019:Tissue Donors; D017086:beta-Thalassemia / Q000235:genetics / Q000378:metabolism / Q000628:therapy*
D011990:Receptors, Transferrin