Indications of reduced pulmonary function in type 1 (insulin-dependent) diabetes mellitus.
Abnormalities of pulmonary function tests have been described in type 1 (insulin-dependent) diabetes mellitus (IDDM). To better characterise such abnormalities and to verify whether these latter are associated with the presence of diabetic microvascular disease we compared 23 non-smoking patients who had IDDM with 24 non-smoking healthy control subjects strictly matched for sex, age, and body mass index. Compared with controls, diabetic patients had a reduced forced vital capacity (FVC) (87.5 +/- 13.1% vs. 96.4 +/- 13.6% of the predicted; P = 0.03) and forced expiratory volume in 1 s (FEV1) (90.5 +/- 17.7% vs. 101.2 +/- 13.2% of the predicted; P = 0.02). While within the group of patients the presence of retinopathy and autonomic neuropathy were not associated with modifications of pulmonary function tests, those with altered urinary albumin excretion rate (AER > or = 20 micrograms/min; range 21-589) (n = 7) had a significantly lower pulmonary diffusion capacity (DLCO) than the 16 normoalbuminuric subjects (62.6 +/- 7.2% vs. 88.7 +/- 20.1% of the predicted; P = 0.01). Moreover, in the group of patients, DLCO was inversely related with AER (r = -0.43; P = 0.04). In conclusion, IDDM is characterised by reduced FVC and FEV1, while a significant decrease in DLCO may be considered as selectively associated with renal disease.
Servizio di Fisiopatologia Respiratoria, Spedali Riuniti, Pistoia, Italy.
F
F
Innocenti
A
A
Fabbri
R
R
Anichini
S
S
Tuci
G
G
Pettinà
F
F
Vannucci
L A
LA
De Giorgio
G
G
Seghieri
D000328:Adult; D000419:Albuminuria; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D003928:Diabetic Nephropathies / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood; D006801:Humans; D008297:Male; D012123:Pulmonary Ventilation; D012016:Reference Values; D012044:Regression Analysis; D012119:Respiration; D012129:Respiratory Function Tests; D014636:Valsalva Maneuver; D014797:Vital Capacity
D001786:Blood Glucose; D006595:Hexosamines; D019270:Fructosamine