Familial occurrence of moyamoya disease. Magnetic resonance angiography as a screening test for high-risk subjects.
The authors report four cases of familial occurrence of moyamoya disease. Although the pathogenesis of moyamoya disease is not clear, there is extensive evidence that this disease has a tendency to show multifactorial inheritance. Therefore, a screening test for those at high risk, i.e., who have a moyamoya patient among their blood relatives, is clinically important. Magnetic resonance angiography (MRA) successfully revealed abnormal findings specific to moyamoya disease in members of the four probands families. MRA is a powerful and noninvasive way of detecting individuals at high risk of developing moyamoya disease.
Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.
K
K
Houkin
N
N
Tanaka
A
A
Takahashi
H
H
Kamiyama
H
H
Abe
N
N
Kajii
D000714:Anastomosis, Surgical; D001163:Arteriovenous Anastomosis; D016893:Carotid Stenosis / Q000503:physiopathology / Q000601:surgery; D002536:Cerebral Arteries / Q000503:physiopathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000503:physiopathology; D018810:Magnetic Resonance Angiography; D009072:Moyamoya Disease / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*