The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations.
From clinical, chemical carcinogenesis and transgenic animal studies, it is evident that wounding has a tumor-promoting effect. We discuss the role of TGF-beta (with special emphasis on TGF-beta 1) in this process and suggest that stromal alterations during wound healing, induced by TGF-beta, can be an important determinant of tumor growth. A tumor and a wound both require similar stromal microenvironments. Thus, a chemically initiated or an oncogene-expressing cell could be complemented to grow into a tumor if it finds itself in a hospitable wound-healing stroma.
Cell and Molecular Biology Department, University of California, Berkeley 94720.
M H
MH
Sieweke
M J
MJ
Bissell
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D003043:Cocarcinogenesis; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000503:physiopathology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
D016212:Transforming Growth Factor beta