Receptor-mediated effects of angiotensin II on neurons.
Aside from its well-known and numerous actions at peripheral tissues, the octapeptide angiotensin II (ANG II) elicits specific receptor-mediated effects within the central nervous system. In this review we focus on the receptor-mediated actions of ANG II on neurons. The distribution of ANG II receptors in the brain and physiological, electrophysiological, and cellular effects mediated by these receptors are discussed. This is extended to a review of the characteristics of ANG II receptor subtypes on cultured neurons and the cellular and genomic actions mediated by these receptors. Finally, we develop this information into speculative models for the cellular effects mediated by each ANG II receptor subtype in neurons.
Sumners
C
C
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610.
Raizada
M K
MK
Kang
J
J
Lu
D
D
Posner
P
P
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000187:drug effects / Q000502:physiology; D001923:Brain Chemistry; D004594:Electrophysiology; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D011945:Receptors, Angiotensin / Q000032:analysis / Q000235:genetics / Q000502:physiology*
D011945:Receptors, Angiotensin; D000804:Angiotensin II