Quantitative analysis of 1-naphthol in urine of neonates exposed to mothballs: the value in infants with unexplained anaemia.
In Nigeria, severe NNJ is common in babies exposed to mothballs and other icterogenic agents. High-performance liquid chromatographic (HPLC) method was employed for quantitative analysis of 1 and 2-naphtol in the urine of 50 neonates aged one to 19 days. Five of the 25 babies who had a history of exposure to mothballs, and none of the babies without a history of exposure had 1-naphtol in their urine. The value of 1-naphtol ranged between 0.75 and 11.69 micrograms/ml with mean of 5 +/- 5 micrograms/ml. The overall correlation coefficient (r) between bilirubin values and 1-naphtol was 0.1 while it was 1 in the three G-6-PD deficient infants. The procedure will be very useful in the evaluation of infants with unexplained NNJ, anaemia, acute haemolytic jaundice and haemoglobinuria if naphthalene poisoning is suspected.
Department of Paediatrics, Obafemi Awolowo University, Ile-Ife.
J A
JA
Owa
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Izedonmwen
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Ogundaini
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Ogungbamila
D000740:Anemia / Q000097:blood / Q000139:chemically induced / Q000652:urine*; D001663:Bilirubin / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood / Q000139:chemically induced / Q000652:urine*; D008297:Male; D009281:Naphthalenes / Q000506:poisoning*; D009284:Naphthols / Q000652:urine*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D009281:Naphthalenes; D009284:Naphthols; C029350:1-naphthol; D001663:Bilirubin