A high-resolution genetic map of mouse chromosome 5 encompassing the reeler (rl) locus.
Using interspecific crosses between BALB/c and Mus spretus (SEG) mice, the murine reeler (rl) gene was mapped to the proximal region of chromosome 5 between the hepatocyte growth factor gene (Hgf) and the D5Mit66 microsatellite. The following order was defined: (centromere)-Cchl2a/Hgf-D5Mit1-D5Nam1/D5-Nam2 -rl/D5Mit61-D5Mit72-Xmv45-Htr5a- Peplb-D5Nam3-D5Mit66. Estimated distances between reeler and the nearest flanking markers D5Nam1 and D5Mit72 are 1.5 and 1.0 cM, respectively (95% confidence level), suggesting that the region could be physically mapped using a manageable number of YAC clones.
Department of Physiology, FUNDP School of Medicine, Namur, Belgium.
M C
MC
Beckers
I
I
Bar
T
T
Huynh-Thu
C
C
Dernoncourt
A L
AL
Brunialti
X
X
Montagutelli
J L
JL
Guénet
A M
AM
Goffinet
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000032:analysis / Q000235:genetics; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D017228:Hepatocyte Growth Factor / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D009115:Muridae; D009928:Organ Specificity; D011995:Recombination, Genetic
D004276:DNA, Satellite; D005819:Genetic Markers; D017228:Hepatocyte Growth Factor; D004247:DNA