Risks and benefits of drugs used in the management and prevention of gout.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are now commonly used for the treatment of acute gout, but caution is required in view of their adverse effects, especially in the elderly. Colchicine is still an effective acute agent, but care must be taken to monitor toxicity. Intra-articular glucocorticosteroid therapy is useful and very safe; oral steroids and corticotrophin (adrenocorticotrophic hormone) may have a small role in acute therapy and seem safe when used over short time spans. Low dose colchicine may have a cost and toxicity advantage over NSAIDs in the prophylaxis of gout when commencing therapy aimed at reducing elevated plasma urate concentrations. Allopurinol is more frequently used than uricosuric agents such as probenecid, and toxicity may be largely avoided by tailoring dosage schedules according to renal function.
Conaghan
P G
PG
Department of Medicine, St Vincent's Hospital, Sydney, Australia.
Day
R O
RO
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003078:Colchicine / Q000008:administration & dosage / Q000627:therapeutic use; D004311:Double-Blind Method; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy* / Q000517:prevention & control; D006074:Gout Suppressants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011339:Probenecid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D013442:Sulfinpyrazone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D006074:Gout Suppressants; D000493:Allopurinol; D000324:Adrenocorticotropic Hormone; D011339:Probenecid; D003078:Colchicine; D013442:Sulfinpyrazone