[A possible risk for geriatric risk patients caused by intraoperative disorder of cerebral energy utilization?].
OBJECTIVE
This study was carried out on cerebrospinal fluid (CSF) to investigate the perioperative course of certain ischaemic markers, namely neurone-specific enolase (NSE), creatine kinase (CK-BB), hypoxanthine, and lactate in order to identify a disturbed cerebral energy utilisation which could be responsible for the development of temporary mental dysfunctions. Those dysfunctions are characterised by preserved memory content and perception, but the coordination and association of these functions are disturbed. Typical clinical signs are motor restlessness, disordered emotions, and symptoms of dementia. Little is known about the aetiology of those symptoms, but they are most likely due to various events, such as direct drug effects, the extent of surgical trauma, sensorial deprivation, and disturbed perfusion.


METHODS
Eight orthopaedic patients (ASA III or IV) scheduled for removal of their total hip replacement were anaesthetised by catheter-spinal anaesthesia (CSA) for pain relief in combination with standardised, modified neuroleptanalgesia (NLA). At six defined times (15 hours preoperatively, immediately before and after surgery and 6, 24, and 36 hours postoperatively) CSF samples were drawn and the ischaemic markers were determined by means of radioimmunoassay (NSE), electrophoresis (CK-BB), photometry (lactate), and high-pressure liquid chromatography (hypoxanthine). The release of ischaemic markers into CSF correlates linear with the extent of ischaemic brain damage.


RESULTS
Mean concentrations of the following ischaemic markers increased in all patients intraoperatively: NSE from 12.3 ng/ml to 13.4 ng/ml, hypoxanthine from 1.86 mumol/l to 3.73 mumol/l, and lactate from 1.4 mmol/l to 2.0 mmol/l respectively, all of which returned to normal within 36 hours. The CK-BB concentrations were all within normal values and not affected by the operation during this investigation.


CONCLUSIONS
Although no clinical signs of temporary mental dysfunction have been observed, the results indicate that in CSF ischaemic markers temporarily undergo certain changes in their concentrations during the removal of total hip replacements in elderly patients. These changes are reason for assuming that risk patients may suffer a temporary disturbed cerebral energy utilisation intraoperatively, even if stable clinical and cardiovascular conditions prevail under anaesthesia. Such a temporary ischaemic penumbra might be responsible for the postoperative development of temporary mental dysfunctions.
Kuhn
D F
DF
Abteilung Anaesthesiologie und Operative Intensivmedizin, Justus-Liebig-Universität Giessen.
Fritz
T
T
Oehmke
M J
MJ
Bachmann
B
B
Hempelmann
G
G
D000368:Aged; D000775:Anesthesia, Spinal; D001812:Blood-Brain Barrier / Q000502:physiology; D002545:Brain Ischemia / Q000503:physiopathology* / Q000517:prevention & control; D003402:Creatine Kinase / Q000134:cerebrospinal fluid; D015140:Dementia, Vascular / Q000503:physiopathology / Q000517:prevention & control; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000134:cerebrospinal fluid; D007431:Intraoperative Complications / Q000503:physiopathology* / Q000517:prevention & control; D007773:Lactates / Q000134:cerebrospinal fluid; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D019965:Neurocognitive Disorders / Q000503:physiopathology* / Q000517:prevention & control; D009458:Neuroleptanalgesia; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D012086:Reoperation
D007042:Hypoxanthines; D007773:Lactates; D019271:Hypoxanthine; D019344:Lactic Acid; D003402:Creatine Kinase; D010751:Phosphopyruvate Hydratase
Ein mögliches Risiko für geriatrische Risikopatienten durch eine intraoperative Störung der zerebralen Energieutilisation?