[The experimental study of the canine auxiliary partial liver transplantation for the liver failure].
A model of hepatic failure was established by injection of galactosamine in CCL4-induced liver cirrhosis. Auxiliary partial liver transplantation (APLT) was carried out to treat those dogs. The survival rate, biochemical change patterns, and histologic changes were investigated in both APLT group and control group. The survival rate in APLT and control group was 59.1% and 7.1% respectively, (P < 0.01). Fair supporting graft function was demonstrated by uptake and excretion of 99mTC-HIDA and 99mTC-DIASA at cholescintigraphy, ammonia aetoxification, synthesis of clotting factors and glucohomeostasis. The results indicate that auxiliary transplantation of a partial liver proviae metabolic support and improve survival in animals with hepatic failure. The character of the model, the advantages and the disadvantages of the APLT, were also discussed.
Affiliated Hospital of Sun Yat-Sen University of Medical Sciences, Guangzhou.
J F
JF
Huang
X S
XS
He
W H
WH
Xuan
D000818:Animals; D004285:Dogs; D005688:Galactosamine; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000150:complications; D017093:Liver Failure / Q000139:chemically induced / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male
D005688:Galactosamine