Prolactin as a second messenger for interleukin 2.
The generation of an effective immune response requires the selection and proliferation of antigen-specific lymphocytes. Activation of at least some T lymphocytes involves the sequential stimulation of cell surface receptors, including the T-cell receptor for antigen, the interleukin 2 receptor, and the prolactin receptor. Prolactin signaling in T lymphocytes appears to utilize a classical receptor-mediated kinase cascade and a novel peptide hormone activation pathway involving nuclear translocation.
Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York 10467.
M B
MB
Prystowsky
C V
CV
Clevenger
D000941:Antigens / Q000276:immunology; D002467:Cell Nucleus / Q000378:metabolism; D007376:Interleukin-2 / Q000502:physiology*; D008213:Lymphocyte Activation / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D011388:Prolactin / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000502:physiology; D011981:Receptors, Prolactin / Q000502:physiology; D015290:Second Messenger Systems
D000941:Antigens; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell; D015375:Receptors, Interleukin-2; D011981:Receptors, Prolactin; D011388:Prolactin