Ileal carcinoid tumors and intestinal ischemia.
Three patients with carcinoid tumors of the ileum are presented; two had severe intestinal ischemia, one with infarction of the small intestine. In all three cases, histopathological examination revealed elastic vascular sclerosis (EVS) in the mesenteric blood vessels. Intestinal ischemia in the presence of a carcinoid tumor is probably due to a combination of tumoral secretion products, vascular changes, mesenterial retraction and nodal involvement. Selective superior mesenteric artery arteriography is diagnostic. All the reported carcinoid tumors with ischemic manifestations are ileal and invaded the mesentery or had positive nodes or metastases; two-thirds had EVS, and one-third mesenterial vascular luminal narrowing. Intestinal ischemia may be the underlying cause of vague symptoms in patients with a carcinoid tumor. This tumor may be small and must be looked for during laparotomy, mild intestinal ischemia or mesenterial thickening are important signs. Early resection can prevent intestinal complications. An aggressive attitude, including debulking of metastases, is justifiable.
Department of Surgery, Kliniek Maria's Voorzienigheid, Kortrijk, Belgium.
L
L
Strobbe
E
E
D'Hondt
C
C
Ramboer
H
H
Ceuppens
P
P
Hinnekens
M
M
Verhamme
D000368:Aged; D000369:Aged, 80 and over; D002276:Carcinoid Tumor / Q000150:complications*; D004547:Elastic Tissue / Q000378:metabolism; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications*; D007082:Ileum / Q000098:blood supply*; D007511:Ischemia / Q000209:etiology*; D008638:Mesenteric Arteries / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D012598:Sclerosis / Q000209:etiology / Q000378:metabolism