[Analyses of PCNA and AgNOR on advanced colorectal cancer as predictive indicators of the prognosis].
As part of a search for predictive indicators of the prognosis of advanced colon cancers, the significance of PCNA and AgNORs in terms of grading of biological malignancy was investigated. In 47 selected cases, which had been sufficiently followed up for the present study, PCNA labeling indices (PCNA LI) were 20.96 +/- 8.87 and 54.78 +/- 11.35 in normal colonic mucosa and colon cancer, respectively. With survival durations of more or less than 5 years, the PCNA LI values were 57.27 +/- 9.56 and 48.27 +/- 13.37, thus, suggesting a decrease with poor prognosis. PCNA LI decreased in proportion to the depth of cancer invasion and the progression of stage. In all of these cases statistically significant differences were apparent, whereas other histopathologic factors did not demonstrate any correlation. Numbers of AgNORs were 1.31 +/- 0.10 and 2.43 +/- 0.39 in normal tissues and cancers, the differences being statistically significant. However, no correlation with prognosis or histopathologic factors was noted for this parameter. In conclusion, our data suggest that PCNA LI might be an important predictive indicator of prognosis in advanced colon cancer. In contrast, AgNORs are of no assistance with this problem, although use of both or combination might facilitate differentiation between benign and malignant lesions.
Nishi
Y
Y
Department of Surgery, Ageo Chuo General Hospital, Japan.
Takano
Y
Y
Kakita
A
A
D000230:Adenocarcinoma / Q000276:immunology / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D016622:Silver Staining; D015996:Survival Rate
D018809:Proliferating Cell Nuclear Antigen