Fluorinated phospholipid-based vesicles as potential drug carriers: encapsulation/sustaining of drugs and stability in human serum.
The release of entrapped 5(6)-carboxyfluorescein from fluorinated vesicles in a buffer or in human serum is considerably less than that from hydrogenated liposomes. The presence of a fluorinated core inside the liposomal membrane definitely reduces its permeability. In some cases, the stability of liposomes made from fluorinated phospholipids alone is better than that of egg phosphatidylcholine cholesterol 1/1 vesicles, which are among the least permeable and most stable hydrogenated liposomes.
Unité de Chimie Moléculaire, associée au Centre National de la Recherche Scientifique, Université de Nice-Sophia Antipolis, France.
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Frezard
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Santaella
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Vierling
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JG
Riess
D001790:Blood Physiological Phenomena; D002021:Buffers; D004337:Drug Carriers; D004355:Drug Stability; D005452:Fluoresceins / Q000008:administration & dosage*; D005456:Fluorescent Dyes; D017611:Fluorine Compounds; D006801:Humans; D008081:Liposomes; D015394:Molecular Structure; D010743:Phospholipids
D002021:Buffers; D004337:Drug Carriers; D005452:Fluoresceins; D005456:Fluorescent Dyes; D017611:Fluorine Compounds; D008081:Liposomes; D010743:Phospholipids; C024098:6-carboxyfluorescein