Levels of CA-19.9, CA-125, and CA-195 in seminal plasma and in vitro fertilization rates.
OBJECTIVE
To assess the relationship between carbohydrate tumor markers in seminal plasma and fertilization rates in IVF cycles.


METHODS
Prospective study.


METHODS
Academic tertiary hospital.


METHODS
Forty-six consecutive couples subjected to IVF in which at least one oocyte was obtained.


METHODS
Determination of CA-19.9, CA-125, and CA-195 in seminal plasma 1 week before IVF.


RESULTS
CA-125 was higher in the group without fertilization (321 +/- 198 U/mL, mean +/- SD) than in the group in which at least one oocyte was fertilized (155 +/- 165 U/mL), whereas CA-19.9 and CA-195 were similar in both groups. However, at the cutoff 66%, lower values of CA-19.9 were found in the fertilization group rate < 66% (707 +/- 1,217 versus 1,069 +/- 1,084) and of CA-195 (67 +/- 44 versus 218 +/- 274). No correlation was found between tumor marker levels and fertilization rates.


CONCLUSIONS
CA-125 seems to be an indicator of sperm fertilization capacity, whereas the importance of CA-195 and CA-19.9 will require further studies.
Matorras
R
R
Department of Obstetrics and Gynecology, País Vasco University, Hospital de Cruces, Baracaldo, Vizcaya, Spain.
Genollá
J
J
Diez
J
J
Corcóstegui
B
B
Neyro
J L
JL
Fombellida
J C
JC
Rodríguez-Escudero
F J
FJ
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D018394:CA-125 Antigen / Q000032:analysis*; D018395:CA-19-9 Antigen / Q000032:analysis*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D012016:Reference Values; D012661:Semen / Q000737:chemistry*
D015295:Antigens, Tumor-Associated, Carbohydrate; D015415:Biomarkers; C081241:CA 195 antigen; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen