[The effect of calcitonin gene-related peptide on the hepatic hemodynamics after releasing of hepatic ischemia].
The effect of synthetic chicken calcitonin gene-related peptide (CGRP) on the hepatic circulation was studied using adult mogrel dogs. Infusion of CGRP (10(-9) M/kg) decreased the mean arterial blood pressure to 56.8% of the pre-infusion value and increased heart rates to 106.3%. 10(-10) M/kg CGRP increased blood flow of the superior mesenteric artery, hepatic artery and portal vein by 130.1%, 130.2%, and 121.2% respectively of the basal levels. The hepatic blood flow was discontinued for 20 minutes by clamping the hepato-duodenal ligament. After reestablishing effects of CGRP on the hepatic hemodynamics became more evident. These results offer the possibility that CGRP may be used to maintain the hepatic blood flow stable during and after hepatic surgery.
Department of Surgery, Omiya Medical Center, Jichi Medical School, Saitama, Japan.
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Yamamoto
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Yasuda
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D007511:Ischemia / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply*; D008102:Liver Circulation / Q000187:drug effects*; D015424:Reperfusion
D015740:Calcitonin Gene-Related Peptide