[Follow-up study of porcine bioprosthetic valve replacement in 15 children].
GD-I porcine bioprosthetic valve replacement were performed in 15 cases from Jul. 1978 to Nov. 1982. Pathology: RHD 11, CHD 4, 13 with MVR, 1 AVR, 1 TVR. One patient died during operation (operative mortality 6.7%). 13 cases were followed up for 3-10 years: in the early years the symptoms and cardiac function were greatly improved and the size reduced. However dysfunction of bioprosthetic valve was detected 2-8 years after operation in 12 patients (19.37%/patient year). The main cause of damage and dysfunction of porcine valve is calcification of the leaflet. As compared with the adult group(dysfunction rate 3.6%/patient year) in this institute, more calcification of the porcine valve in children is considered because of: (1) stronger metabolism of calcium in children, (2) less mobility of the leaflet due to lower cardiac output in children, and (3) stronger immunoreaction to porcine valve in children.
Guangdong Provincial People's Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou.
J G
JG
He
J F
JF
Zhang
Z X
ZX
Luo
D000293:Adolescent; D001705:Bioprosthesis; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000601:surgery*; D006349:Heart Valve Diseases / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D012214:Rheumatic Heart Disease / Q000601:surgery