Enhancement of 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by phenethylphthalimide analogs.
Effects of phenyl-, benzyl-, phenethyl-, and phenylpropylphthalimides on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-alpha production by human leukemia cell line HL-60 were examined. Among the four phthalimide derivatives, only phenethylphthalimide showed potent enhancing effect on TNF-alpha production.
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
K
K
Sasaki
Y
Y
Shibata
K
K
Nishimura
Y
Y
Hashimoto
S
S
Iwasaki
D006801:Humans; D007942:Leukemia, Experimental / Q000378:metabolism; D010797:Phthalimides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D010797:Phthalimides; D014409:Tumor Necrosis Factor-alpha; D013755:Tetradecanoylphorbol Acetate