Effect of praziquantel on sex hormone levels in murine schistosomiasis mansoni.
Changes in sex hormonal levels were studied in Schistosoma mansoni infected and praziquantel treated mice (400 x 2 mg/Kg), drug control and in normal control groups. It was observed that schistosomiasis lead to increase in the level of testosterone, progesterone and 17B-esteradiol, 60 and 70 days postinfection in male and female mice, respectively. In praziquantel treated group the level of testosterone was lowered 10, 20 & 30 days post treatment, progesterone and 17 beta-estradiol fell 30 days post treatment after primary rise. The mechanism of recorded changes will be discussed in details.
Abdalla
K F
KF
Department of Parasitology, Benha Faculty of Medicine, Benha Branch of Zagazig University, Egypt.
Abdel-Aziz
S M
SM
el Fakahany
A F
AF
el-Hamshary
A S
AS
Afifi
L M
LM
D000818:Animals; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D010053:Ovary / Q000187:drug effects; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D011374:Progesterone / Q000378:metabolism*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000378:metabolism; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D011223:Praziquantel