1 alpha,25(OH)2 vitamin D3-regulated expression of the eukaryotic genome.
1 alpha,25(OH)2vitamin-D3, [1 alpha,25(OH)2D3] is a potent steroid hormone that produces a wide array of biologic effects in a variety of target tissues within the body through its ability to modulate gene transcription of specific target genes. Evidence for transcription regulation of a specific gene typically includes 1 alpha,25(OH)2D3-induced modulation in mRNA levels. Additionally, evidence may include measurements of transcription and/or the presence of a vitamin D response element within the promoter region of the gene. To date, over 50 genes have been reported to be transcriptionally regulated by 1 alpha,25(OH)2D3. We present a current list of these genes and the evidence supporting their inclusion on the list.
Hannah
S S
SS
Department of Chemistry, University of California, Riverside.
Norman
A W
AW
D000818:Animals; D002117:Calcitriol / Q000096:biosynthesis / Q000235:genetics*; D005786:Gene Expression Regulation; D005796:Genes / Q000235:genetics; D016678:Genome; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics
D012333:RNA, Messenger; D002117:Calcitriol