Determination of a maximum number of artificial inseminations by donor children per sperm donor.
OBJECTIVE
To determine a safe maximum number of artificial insemination (donor insemination [DI]) children per anonymous sperm donor.


METHODS
Multiparameter calculation model of contribution of DI to inbreeding.


METHODS
Data of the collaborative DI centers and demographic population data of The Netherlands.


METHODS
Calculations of the contribution of DI to inbreeding were made, taking into account all possible unintentional consanguineous matings and consanguineous inseminations with a coefficient of inbreeding (F) of > or = 1/16 for the offspring.


METHODS
Coefficient of inbreeding (F).


RESULTS
The contribution of DI to inbreeding was estimated to be 46.6 x 10(-6) + k (1.66 x 10(-6)) (k = number of DI children per donor). When only half-sibling matings were considered, the kmax was 32. When all possible consanguineous matings and inseminations were taken into account, kmax decreased with 28% to 25 children.


CONCLUSIONS
Calculations of a maximum number of DI children per sperm donor, based on possible enhancement of inbreeding and given the Dutch population and DI setting, show that 25 children per DI donor is a safe threshold for clinical practice.
de Boer
A
A
Department of Clinical Epidemiology, University Hospital, Leiden, The Netherlands.
Oosterwijk
J C
JC
Rigters-Aris
C A
CA
D003241:Consanguinity; D005260:Female; D006801:Humans; D007316:Insemination, Artificial, Heterologous; D008297:Male; D009426:Netherlands; D011247:Pregnancy; D011336:Probability