Increased levels of circulating intercellular adhesion molecule-1 in patients with systemic sclerosis.
OBJECTIVE
To determine the value of the circulating intercellular adhesion molecule (cICAM-1) as a marker for the inflammatory and fibrotic processes in systemic sclerosis (SSc).


METHODS
We determined serum levels of cICAM-1 and of the soluble interleukin-2 receptor (sIL-2R) by an enzyme-linked immunosorbent assay in 33 patients with SSc. These values were compared to the concentrations of acute phase reactants and to the extent of skin involvement in diffuse and limited scleroderma.


RESULTS
cICAM-1 was elevated in patients with diffuse SSc (498 +/- 134 ng/ml) as compared with 82 healthy controls (312 +/- 71 ng/ml) (mean +/- SD, p < 0.0001). The elevation of cICAM-1 did not correlate with the duration of disease, the pattern of organ manifestations or the type of treatment. While the concentrations of acute phase proteins were not elevated in SSc, a significant correlation between increased serum sIL-2R and cICAM-1 was observed.


CONCLUSIONS
Increased levels of cICAM-1 indicate an activation of immune processes in SSc. The clinical value of the cICAM-1 determination in SSc can only be judged in longitudinal studies.
Department of Internal Medicine I, University of Vienna, Austria.
H
H
Kiener
W
W
Graninger
K
K
Machold
M
M
Aringer
W B
WB
Graninger
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000097:blood* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012995:Solubility
D015415:Biomarkers; D015375:Receptors, Interleukin-2; D018799:Intercellular Adhesion Molecule-1