Passive cross-protection provided by antisera directed against in-vivo-expressed antigens of Pasteurella multocida.
Chicken antisera produced against the detergent-insoluble fraction of in vivo-grown P-1059 (serotype 3) Pasteurella multocida passively protected against heterologous X-73 (serotype 1) challenge. Likewise, antisera from chickens that survived infection by live P-1059 provided passive heterologous protection. The two antisera, which contained cross-protection antibodies, were adsorbed with the detergent-insoluble fraction of in vitro-grown P-1059 and still passively cross-protected against heterologous serotype challenge. The proteins of in vivo-grown P-1059 that had molecular weights of 204,000, 192,000, 179,000, and 153,000, which were recognized by the adsorbed antisera on immunoblots, may be responsible for cross-protection.
Department of Avian Medicine, University of Georgia, Athens 30602-4875.
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Wang
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Glisson
D000818:Animals; D000907:Antibodies, Bacterial / Q000302:isolation & purification; D000942:Antigens, Bacterial / Q000302:isolation & purification; D001426:Bacterial Proteins / Q000276:immunology / Q000302:isolation & purification; D002645:Chickens; D007116:Immunization, Passive; D008970:Molecular Weight; D010326:Pasteurella Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000145:classification / Q000254:growth & development / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology / Q000517:prevention & control*; D012703:Serotyping; D014422:Turkeys
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins