Prognostic values of preoperative and postoperative CEA and CA19.9 levels in pancreatic cancer.
Preoperative serum levels of carcinoembryonic antigen (CEA) and/or carbohydrate antigen 19.9 (CA19.9) were measured in 90 patients with advanced pancreatic cancer. CEA antigen was above the cutoff levels of 5.0 ng/ml in 51% of patients and CA19.9 was above the cutoff limit of 37 U/ml in 87% of patients. High preoperative CEA and CA19.9 levels were related to a poor prognosis of the patients. In multivariate analysis, the hazard rate was significantly higher in the high-CEA group (> 2.5 ng/ml) compared to the low-CEA group (< 2.4 ng/ml). An increase in CEA and/or CA19.9 within 1 month after the operation was also significantly related to the hazard rate. This study reconfirms the prognostic importance of preoperative and postoperative CEA and CA19.9.
Yasue
M
M
Department of Surgery, Aichi Prefectural Hospital, Okazaki, Japan.
Sakamoto
J
J
Teramukai
S
S
Morimoto
T
T
Yasui
K
K
Kuno
N
N
Kurimoto
K
K
Ohashi
Y
Y
D018395:CA-19-9 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D006801:Humans; D015592:Immunoradiometric Assay; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D011379:Prognosis; D011863:Radioimmunoassay; D012680:Sensitivity and Specificity
D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen