Spurious fibrinogen levels secondary to pyroglobulinemia in Waldenström's macroglobulinemia.
We report two cases of pyroglobulinemia detected in the course of routine determination of fibrinogen levels measured by the heat-precipitation method and that led to the diagnosis of Waldenström's macroglobulinemia. The incidence of pyroglobulinemia is briefly discussed, and the potential significance of this laboratory artifact is emphasized.
Cagnoni
P J
PJ
Department of Medicine, Mount Sinai School of Medicine, New York, New York.
Lenzi
R
R
Wisch
N
N
Seremetis
S
S
Rand
J H
JH
D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000473:pathology; D011232:Chemical Precipitation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood / Q000652:urine; D008875:Middle Aged; D011750:Pyroglobulins / Q000378:metabolism*; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D011750:Pyroglobulins; D005340:Fibrinogen