Protection against alloxan-induced diabetes by various dialkyldithiocarbamates.
Dialkyldithiocarbamates injected into mice 0.5 h prior to alloxan protected dose-dependently against the diabetogenic action of alloxan, and increased blood glucose levels at the time of alloxan injection. Furthermore, they exhibited anti-oxidative properties in vitro such as inhibition of lipid peroxidation, removal of hydrogen peroxide and reduction of the stable free radical, 1, 1-diphenyl-2-picrylhydrazyl (DPPH). These results suggest that dialkyldithiocarbamates protect against the development of alloxan-induced diabetes by the indirect mechanism of producing hyperglycemia at the time of alloxan injection and possibly by their anti-oxidative effects as well.
Department of Clinical Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
T
T
Masukawa
K
K
Nakanishi
J
J
Katakawa
T
T
Tetsumi
D000496:Alloxan / Q000037:antagonists & inhibitors*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D004125:Dimethyldithiocarbamate / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D013859:Thiocarbamates / Q000494:pharmacology*
D004125:Dimethyldithiocarbamate; D008054:Lipid Peroxides; D013859:Thiocarbamates; D000496:Alloxan; D004050:Ditiocarb; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase