Down syndrome associated with systemic lupus erythematosus: a mere coincidence or a significant association?
An 8-year-old male, who had Down syndrome associated with systemic lupus erythematosus (SLE), is described. He also had a partial complement 4 deficiency. This case is a reminder that the physician should be aware of the possibility of an immune defect in a male presenting with SLE at a young age. The question of whether the association of Down syndrome with SLE is coincidental or whether there is a predilection for autoimmune disorders in Down syndrome is discussed.
Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Sihhiye Ankara, Turkey.
A
A
Bakkaloglu
S
S
Ozen
N
N
Besbas
U
U
Saatci
S
S
Balci
D002648:Child; D003181:Complement C4 / Q000172:deficiency*; D004314:Down Syndrome / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male
D003181:Complement C4