Cancer procoagulant.
Cancer procoagulant is a unique cysteine proteinase. The enzyme has been purified by several procedures and many of its characteristics and enzymatic properties have been determined. Several sensitive and reproducible assays are now available. Many proteinase inhibitors have been evaluated for their effect on CP; most low molecular weight inhibitors work well in a reduced environment. In the foreseeable future, protein and gene sequence information, expression vectors, molecular probes, and highly specific antibodies and inhibitors should provide the research tools to delineate a functional understanding of CP at the molecular and cellular level.
Gordon
S G
SG
Department of Pathology, University of Colorado, Health Sciences Center, Denver 80262.
D000818:Animals; D003546:Cysteine Endopeptidases / Q000032:analysis* / Q000737:chemistry; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D005170:Factor X; D006801:Humans; D009363:Neoplasm Proteins; D009369:Neoplasms / Q000201:enzymology; D014914:Whole Blood Coagulation Time
D015853:Cysteine Proteinase Inhibitors; D009363:Neoplasm Proteins; D005170:Factor X; D003546:Cysteine Endopeptidases; C030910:cancer procoagulant