Gaucher's disease, type I (adult type), with massive involvement of the kidneys and lungs.
A 33-year-old Japanese male, first diagnosed as having Gaucher's disease at the age of 3 years, died of renal and pulmonary failure. Autopsy findings disclosed the proliferation of Gaucher's cells in the liver, bone marrow, lymph nodes, kidneys and lungs. Electron-microscopical findings suggested that the Gaucher's cells observed in the renal glomeruli might be derived from circulating macrophages.
Department of First Pathology, Fukushima Medical College, Japan.
Y
Y
Morimura
H
H
Hojo
M
M
Abe
H
H
Wakasa
D000328:Adult; D005776:Gaucher Disease / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron