Tuberculosis in relation to a history of peptic ulcer disease and treatment of gastric hyperacidity.
Previous studies described an excess of tuberculosis among persons with a history of partial gastrectomy for the treatment of peptic ulcer disease. It is unknown if any contemporary therapies for peptic ulcer disease, such as histamine type 2 antagonists and antacids, are also associated with elevated risks of tuberculosis. A case-control study was conducted during 1988-1990 in the Seattle-King County Tuberculosis Clinic to address these questions. Self-administered questionnaires were completed by 135 cases with active tuberculosis and 380 controls. A history of daily antacid use was reported by 11 cases (8%) and 23 controls (6%), corresponding to an adjusted odds ratio of 0.9 (95% confidence interval 0.4-2.0). A history of daily histamine type 2 antagonist use was reported by nine cases (7%) and 18 controls (5%) with an adjusted odds ratio of 0.8 (95% confidence interval 0.3-2.1). Our results, while based on a relatively small number of subjects, suggest that treatment for peptic ulcer disease has no influence on the occurrence of tuberculosis.
Seattle-King County Department of Public Health, WA.
S E
SE
Buskin
N S
NS
Weiss
J L
JL
Gale
C M
CM
Nolan
D000328:Adult; D000863:Antacids / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D005744:Gastric Acid / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy / Q000601:surgery*; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014376:Tuberculosis / Q000453:epidemiology / Q000209:etiology*; D014861:Washington / Q000453:epidemiology
D000863:Antacids; D006635:Histamine H2 Antagonists