[Outcome of hemorrhage treatment in children with hemophilia A related to factor VIII inhibitor].
The results of bleedings treatment in 11 children with haemophilia A and factor VIII (f. VIII) inhibitor was presented. Concentrates of human and porcine f. VIII and activated prothrombin complex concentrate were used in the treatment. The method of treatment depended on the level of human and porcine f. VIII inhibitors. In patients with level of human f. VIII inhibitor lower than 10 jB/ml the concentrates of human f. VIII in doses 2-3 times higher than usually used in haemophiliacs without inhibitor were successful. When inhibitor level was higher than 10 jB/ml, but low cross-reactivity of porcine f. VIII was stated, concentrates of porcine f. VIII were used with good result. In children with high level of antibody against human and porcine f. VIII, the best results were achieved using activated prothrombin complex concentrates.
Katedry i Kliniki Pediatrii, Hematologii i Onkologii AM, Warszawie.
A
A
Klukowska
B
B
Zieleniewska
D000293:Adolescent; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000627:therapeutic use*; D006467:Hemophilia A / Q000628:therapy*; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans
D001779:Blood Coagulation Factors; D005169:Factor VIII
Wyniki leczenia krwawień u dzieci chorych na hemofilie A, powikłana inhibitorem czynnika VIII.