Phaeochromocytoma: intraoperative changes in blood pressure and plasma catecholamines.
The aim of this study was to assess the relationship between changes in plasma catecholamine concentrations and intra-arterial blood pressure (BP) measured simultaneously during resection of phaeochromocytoma (n = 14). Arterial plasma concentrations of noradrenaline (NA), adrenaline (A) and dopamine (DA) were measured by a radio-enzymatic method. Arterial NA concentrations (pmol/ml; median and Wilcoxon 95% CI) were 71.8 (46,162) before induction of anaesthesia, 113.0 (79,231) after intubation, 375.0 (285,931) during tumour handling and 32.5 (18,88) following tumour removal. Simultaneous mean BP values (mmHg; Mean +/- SEM) were 119 +/- 8, 114 +/- 7, 159 +/- 7 (p = 0.0001) and 72 +/- 6 (p < 0.0001) respectively. At the time of tumour handling there was a weak correlation between plasma NA and A combined and mean BP (r = 0.583, p = 0.029) and a stronger correlation between log plasma NA and A combined and pulse pressure (r = 0.749, p = 0.008). The very large rises in plasma catecholamine concentrations and in BP are likely to have been causally related. Individual patients maintained a constant ratio of NA to A in plasma from pre-induction to tumour handling (r = 0.916, p < 0.0001). The maintenance of a constant NA:A ratio suggests that the pattern of catecholamine synthesis and release may be a characteristic of the individual tumour.
Tonkin
A L
AL
Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia.
Frewin
D B
DB
Russell
W J
WJ
Jonsson
J R
JR
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002395:Catecholamines / Q000097:blood*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D012044:Regression Analysis; D012189:Retrospective Studies
D002395:Catecholamines