Simultaneous onset of Vogt-Koyanagi-Harada syndrome in monozygotic twins.
OBJECTIVE
We examined monozygotic twins of Vietnamese ancestry in whom the Vogt-Koyanagi-Harada syndrome developed.


CONCLUSIONS
Both patients demonstrated typical clinical findings of the Vogt-Koyanagi-Harada syndrome, and HLA typing disclosed HLA-DR4, an antigen that is present in a disproportionate number of patients with the Vogt-Koyanagi-Harada syndrome. Although familial cases of the Vogt-Koyanagi-Harada syndrome are rare, associations with HLA antigens may indicate that genetic factors play a role in this disease.
Doheny Eye Institute, Los Angeles, CA 90033.
A R
AR
Rutzen
G
G
Ortega-Larrocea
I R
IR
Schwab
N A
NA
Rao
D000293:Adolescent; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D015804:HLA-DR4 Antigen / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D014430:Twins, Monozygotic; D014607:Uveomeningoencephalitic Syndrome / Q000235:genetics*
D015804:HLA-DR4 Antigen