[Single dose toxicity study of lactitol (NS-4) in dogs].
Male beagle dogs were orally given lactitol, a hepatic encephalopathy drug, in a single dose of 7.5, 15.0 or 30.0 g/kg. Vomiting was seen within 30 minutes after dosing in all treated groups. Diarrhea was observed 3 or 5 hours after dosing in the 15.0 and 30.0 g/kg dose groups. There were no drug related effects on survival, food and water consumption, body weight gain or tissues and organs.
Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan.
R
R
Nagata
M
M
Onishi
K
K
Okasaki
Y
Y
Hamasu
N
N
Sumi
D000284:Administration, Oral; D000818:Animals; D003967:Diarrhea / Q000139:chemically induced; D004285:Dogs; D008297:Male; D013402:Sugar Alcohols / Q000008:administration & dosage / Q000633:toxicity*; D014839:Vomiting / Q000139:chemically induced
D013402:Sugar Alcohols; C014635:lactitol