[Osteocalcin and smoking].
Smoking is a risk factor for osteoporosis. Nicotine and nonnicotine tobacco smoke components have been shown to depress osteoblast activity in a number of in vitro and animal studies. To determine whether smoking is associated with depressed osteoblast activity in humans, we measured serum osteocalcin levels (using a radioimmunological method based on an antibody to human osteocalcin) in 24 male or female smokers and 24 matched nonsmokers. Overall, osteocalcin levels were significantly lower in smokers (15 +/- 6.95 ng/ml) than in nonsmokers (21.27 +/- 8.34 ng/ml) (p = 0.007). The difference between smokers and nonsmokers was significant in males (15.3 +/- 4.5 vs 23.27 +/- 9.7; p = 0.02) but not in females (16.27 +/- 8.9 vs 19.45 +/- 6.7; p = 0.2). These data suggest that smoking may induce osteoblast depression, either directly or via hormonal changes.
Service de Rhumatologie, CHU Rangueil Toulouse.
M
M
Laroche
Y
Y
Lasne
A
A
Felez
L
L
Moulinier
E
E
Bon
A
A
Cantagrel
P
P
Léophonte
B
B
Mazières
D000328:Adult; D016723:Bone Remodeling; D005260:Female; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000378:metabolism; D015675:Osteocalcin / Q000097:blood*; D012737:Sex Factors; D012907:Smoking / Q000378:metabolism
D015675:Osteocalcin
Ostéocalcine et tabagisme.