Putative functional domain within ORF2 on the Mycobacterium insertion sequences IS900 and IS902.
Repeated DNA sequences have been identified in a range of mycobacterial species and have been implicated in the increased virulence of some of these species, namely, Mycobacterium paratuberculosis and M. avium subsp. silvaticum. Here we present a case to suggest that the insertion sequences IS900 and IS902 encode a protein from a putative gene positioned on the complementary strand to their transposase genes. Based on amino acid homology analyses, this open reading frame (ORF2) could encode a transport protein. The ORF2 protein thus IS900 and IS902, may have a role in the increased pathogenicity of M. paratuberculosis and M. avium subsp. silvaticum from an M. avium background.
Doran
T J
TJ
CSIRO Division of Animal Health, Melbourne, Victoria, Australia.
Davies
J K
JK
Radford
A J
AJ
Hodgson
A L
AL
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000032:analysis; D001483:Base Sequence; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000032:analysis; D008969:Molecular Sequence Data; D009161:Mycobacterium / Q000235:genetics* / Q000472:pathogenicity; D009713:Nucleotidyltransferases / Q000235:genetics; D016366:Open Reading Frames; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D019895:Transposases; D014774:Virulence
D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D009713:Nucleotidyltransferases; D019895:Transposases