Use of flutamide for self-induced androgen excess. A case report.
A 28-year-old woman developed hirsutism, facial edema and clitoromegaly after self-injection of long-acting synthetic androgens. The symptoms were ameliorated by administration of flutamide with a combination oral contraceptive. Flutamide appears to be useful in preventing sequelae of acute androgen excess in women and may be a rational therapy for chronic treatment of androgen excess in women.
Howe
R S
RS
Department of Obstetrics and Gynecology, Baystate Medical Center, Springfield, Massachusetts.
Chow
R P
RP
Stevens
C L
CL
D000328:Adult; D002987:Clitoris / Q000187:drug effects*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005485:Flutamide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006628:Hirsutism / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D006984:Hypertrophy / Q000139:chemically induced / Q000188:drug therapy; D010259:Paranoid Disorders / Q000139:chemically induced* / Q000188:drug therapy; D045165:Testosterone Congeners / Q000009:adverse effects*
D045165:Testosterone Congeners; D005485:Flutamide