[Regulating effect of electro-acupuncture on dysrythmia of gastro-colonic electric activity induced by erythromycine in rabbits].
The myoelectric activity of gastro-colon was recorded in 20 rabbits. The model of gastro-colonic disorder was produced by vena injection of erythromycine (EM) (7 mg/kg). We investigated regulating effect of electro-acupuncture (EA) on the disorder of gastrocolonic electric activity (GEA). After the vagotomy the effect of EA was observed. In fasting and anaesthetic rabbits, the frequency and amplitude of GEA were 4.47 +/- 1.23 cmp, 1.90 +/- 0.27 mV at antrum, 8.33 +/- 2.61 cpm, 0.51 +/- 0.12 mV at ascending colon, 6.74 +/- 2.68 cpm, 0.35 +/- 0.10 mV at descending colon. After injection of EM, the frequency and amplitude of GEA were increased, the latency and duration of EM effect were 36.5 +/- 4.5 min and 3.8 +/- 1.4 min, the great contraction wave was showed. EA could shorten the duration and latency, decrease the frequency, amplitude and variation coefficient of GEA. After vagotomy the effect of EA disappeared. These results indicate that vagus nerve plays an important role in regulating effect of EA on gastro-colonic disorder.
Xu
G
G
Institute of Acupuncture and Meridian, Anhui College of TCM, Hefei, China.
D000818:Animals; D003106:Colon / Q000503:physiopathology*; D015671:Electroacupuncture; D004594:Electrophysiology; D004917:Erythromycin / Q000009:adverse effects*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D011817:Rabbits; D013270:Stomach / Q000503:physiopathology*; D014628:Vagotomy
D004917:Erythromycin