4H-pyrrolo[1,2-a]thieno[3,2-f] and 4H-pyrrolo[1,2-a]thieno-[2,3-f][1,4]diazepines: synthesis and pharmacological evaluation.
As an extension of a previous work, in which a number of 4H-pyrrolo-[1,2-a]thieno[2,3-f][1,4]diazepines were described, a new series of derivatives of the isomeric pyrrolo[1,2-a]thieno[3,2-f]diazepines ring system has been synthesized. The products obtained, together with those reported in the previous paper, were tested for acute toxicity and CNS activity in mice.
Vega
S
S
Instituto de Química Médica, CSIC, Madrid, Spain.
Gil
M S
MS
Darias
V
V
Sánchez Mateo
C C
CC
Expósito
M A
MA
Tello
M L
ML
Albertos
L M
LM
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D014151:Anti-Anxiety Agents; D001381:Azepines; D011758:Pyrroles