[Diagnostic and therapeutic strategy of Zollinger-Ellison syndrome. Groupe de Recherches et d'Etudes du Syndrome de Zollinger-Ellison (GRESZE)].
The current strategy recommended for Zollinger-Ellison syndrome (ZES) has significantly improved the outcome of this condition. Diagnosis is based on determinations of basal and post-secretin gastric acid output and serum gastrin levels. A crucial step is differentiation of patients with sporadic ZES from those with multiple endocrine neoplasia type 1 syndrome. Only the former should undergo excision of the tumor when feasible. All available imaging techniques should be used pre- and intra-operatively to detect tumorous lesions. Exploratory laparatomy is warranted in patients who have sporadic ZES without evidence of liver metastases.
Service de Gastro-entérologie, CHU Bichat-Claude-Bernard, Paris.
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G
Bonnaud
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G
Cadiot
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M
Mignon
D005745:Gastric Acidity Determination; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D054328:Proton Pump Inhibitors; D013004:Somatostatin / Q000031:analogs & derivatives; D015043:Zollinger-Ellison Syndrome / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy
D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D013004:Somatostatin
Stratégie diagnostique et thérapeutique du syndrome de Zollinger-Ellison. Groupe de Recherches et d'Etudes du Syndrome de Zollinger-Ellison (GRESZE).