Genomic imprinting proposed as a surveillance mechanism for chromosome loss.
One consequence of genomic imprinting is that loss of the transcriptionally active chromosomal homologue causes a change in gene expression that might permit surveillance of chromosome-loss events. Possible selective advantages of such surveillance include protection against cancer and early elimination of monosomic and trisomic fetuses. Potential mechanisms for such surveillance are discussed.
Thomas
J H
JH
Department of Genetics, University of Washington, Seattle 98195.
D000818:Animals; D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics; D002872:Chromosome Deletion; D016678:Genome; D018392:Genomic Imprinting; D006801:Humans; D008957:Models, Genetic; D009006:Monosomy; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D014314:Trisomy; D009396:Wilms Tumor / Q000235:genetics