Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer.
High levels of IL-6 were found in 50% of 114 patients with primary ovarian cancer. IL-6 sensitivity was lower than that of CA 125, and the combination of both assays did not increase the sensitivity of CA 125 alone. However, elevated IL-6 serum levels were correlated with a poor prognosis since patients with low IL-6 levels had a better survival than patients with high IL-6 levels (P = 0.0009). Multivariate analysis revealed that IL-6 positivity has an independent value.
Department of Gynecology and Obstetrics, Catholic University, Rome, Italy.
G
G
Scambia
U
U
Testa
P
P
Benedetti Panici
E
E
Foti
R
R
Martucci
A
A
Gadducci
A
A
Perillo
V
V
Facchini
C
C
Peschle
S
S
Mancuso
D000328:Adult; D000368:Aged; D001201:Ascites; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D015993:Life Tables; D008875:Middle Aged; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000097:blood*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012680:Sensitivity and Specificity; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D015850:Interleukin-6; D009363:Neoplasm Proteins