Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage.
Interleukin-1 (IL-1) is a key mediator in the pathogenesis of cartilage destruction in arthritis-related disorders. Human recombinant superoxide dismutase (SOD) blocked IL-1-mediated cartilage destruction but had no effect on IL-1-mediated changes in glycosaminoglycan and prostaglandin E2 synthesis. These data suggest that superoxide anions may be one factor of IL-1-mediated cartilage destruction.
Fukuda
K
K
Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, Japan.
Dan
H
H
Saitoh
M
M
Takayama
M
M
Tanaka
S
S
D000368:Aged; D000369:Aged, 80 and over; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism; D015232:Dinoprostone / Q000096:biosynthesis; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000633:toxicity; D007700:Kinetics; D008875:Middle Aged; D009924:Organ Culture Techniques; D013482:Superoxide Dismutase / Q000494:pharmacology*
D006025:Glycosaminoglycans; D007375:Interleukin-1; D013482:Superoxide Dismutase; D015232:Dinoprostone