[Localized magnetic resonance spectroscopy: diagnostic applications].
Some of the main experimental requirements limiting, till now, the clinical development of nuclear magnetic resonance (NMR) spectroscopy are discussed, with particular attention to the scarce sensitivity, low resolution and problems of spatial localization. A concise description is then given of the principal biological compounds which can be studied by this peculiar type of spectroscopy, together with the main categories of biochemical information that can be extracted from their detection, i.e. especially at the level of intermediate and energetic metabolism. In conclusion, some of the more outstanding examples selected from human clinical studies are depicted, particularly emphasizing those focused on the skeletal muscle system.
Di Vito
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Laboratorio di Biologia Cellulare, Istituto Superiore di Sanità, Roma.
D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
Spettroscopia di risonanza magnetica localizzata: applicazioni diagnostiche.