[Metabolism of the basic component of connective tissue at various stages of developing experimental liver cirrhosis].
A system of GAG-hydrolase was studied in liver tissue and blood plasma during development of CCl4-produced cirrhosis of liver tissue in series of experiments involving 400 adult rat males. Dissimilar pathways of the matrix formation, related to dynamics of the GAG-hydrolases activity, were detected within various steps of the chronic CCL4-produced liver tissue impairments in these rats. Alterations in the enzymatic activity were stable and regular in each series of the experiment and correlated with dynamics of the adaptation-compensatory responses.
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Skobeleva
D000818:Animals; D002251:Carbon Tetrachloride; D003238:Connective Tissue / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D006025:Glycosaminoglycans / Q000378:metabolism; D007068:Iduronidase / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D006025:Glycosaminoglycans; D002251:Carbon Tetrachloride; D007068:Iduronidase
Metabolizm osnovnogo veshchestva soedinitel'noĭ tkani na razlichnykh stadiiakh razvitiia éksperimental'nogo tsirroza pecheni.