Interstitial pneumonitis induced in guinea pigs by Triatoma infestans antigens.
Data concerning the experimental induction of hypersensitivity pneumonitis in guinea pigs with a Triatoma infestans antigen are presented. Glycoproteins obtained from the chitinous structures of T. infestans (79 kd + 11 kd) were aerosolized daily to guinea pigs during 7 weeks. The presence of specific antibodies (IgG and IgE) was detected by serological techniques; histopathological studies of the lungs showed interstitial infiltrates of macrophages and T-cells. Single non-necrotizing granulomas were seen at the seventh week of the experiment. The results from this animal model suggest that this hypersensitivity pneumonitis is a typical delayed-type reaction due to chronic contact with the heterologous glycoproteins of T. infestans.
Alonso
A
A
Allergy Center, Clinical Hospital, Buenos Aires, Argentina.
Caccuri
R L
RL
Scavini
L M
LM
Rodríguez
S M
SM
Marino
G A
GA
D000336:Aerosols; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D002686:Chitin / Q000276:immunology; D004195:Disease Models, Animal; D006023:Glycoproteins / Q000276:immunology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology / Q000473:pathology; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D014224:Triatoma / Q000276:immunology*
D000336:Aerosols; D000941:Antigens; D006023:Glycoproteins; D007074:Immunoglobulin G; D002686:Chitin; D007073:Immunoglobulin E