Up-regulation of GAP-43 (B50/F1) gene expression in vestibular efferent neurons following labyrinthectomy in the rat: in situ hybridization using an alkaline phosphatase-labeled probe.
Growth-associated protein (GAP)-43 plays a significant role in nerve regeneration and synaptic remodeling. We examined the profiles of GAP-43 mRNA expression in vestibular efferent neurons after labyrinthectomy in adult rats, and clearly demonstrated that labyrinthectomy increased GAP-43 expression in these neurons. This finding suggests the ability of vestibular efferent nerves to regenerate after nerve injury.
Department of Otolaryngology, Osaka University Medical School, Japan.
K
K
Ohno
N
N
Takeda
T
T
Kubo
H
H
Kiyama
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D007758:Ear, Inner / Q000601:surgery; D019922:GAP-43 Protein; D005786:Gene Expression Regulation / Q000235:genetics*; D017403:In Situ Hybridization; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016900:Neurofilament Proteins / Q000235:genetics*; D009476:Neurons, Efferent / Q000166:cytology / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation; D014722:Vestibule, Labyrinth / Q000294:innervation*
D019922:GAP-43 Protein; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; D012333:RNA, Messenger; D000469:Alkaline Phosphatase