Morphological changes in the tectorial and basilar membranes of aged rats.
Using both light and transmission electron microscopy presbycusic degeneration of the cochlea was observed in particular in the tectorial and basilar membranes, in naturally aged rats. These animals showed a descending auditory pattern as determined by auditory brainstem response. Ultrastructurally, the number of collagen fibers in the tectorial membrane was reduced and straight type A fibers were increased relative to branched, coiled type B fibers. The basilar membrane in the basal turn was also thickened by an increased homogeneous ground substance. These findings indicate that the specificity of vibration of the tectorial and basal membranes is very different in aged and young rats.
Department of Otorhinolaryngology, Saitama Medical Center, Saitama Medical School, Japan.
K
K
Ishii
T
T
Murofushi
N
N
Takeuchi
D000375:Aging / Q000473:pathology*; D000818:Animals; D001309:Auditory Threshold; D001489:Basilar Membrane / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D003094:Collagen / Q000378:metabolism; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar; D013680:Tectorial Membrane / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
D003094:Collagen