Histidine and aspartate phosphorylation: two-component systems and the limits of homology.
Autophosphorylating histidine kinase and response-regulator domains constitute the building blocks of two-component signaling systems. These systems use a unique phosphotransfer chemistry to regulate many aspects of bacterial physiology. Homologous systems are now being found in eukaryotes. Despite their common mechanism of phosphotransfer, the two-component systems display an extensive diversity in the arrangement of their domains, and flexibility in their roles in different signal transduction circuits.
Division of Biology, California Institute of Technology, Pasadena 91125.
R V
RV
Swanson
L A
LA
Alex
M I
MI
Simon
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism*; D010766:Phosphorylation; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology
D001224:Aspartic Acid; D006639:Histidine