Ketoconazole for prevention of postoperative penile erection.
OBJECTIVE
To determine if ketoconazole, an inhibitor of testosterone synthesis, can prevent postoperative spontaneous erections in patients undergoing penile surgery.


METHODS
Ketoconazole was administered to 8 patients, aged 14 to 42 years, who underwent penile surgery. All patients received ketoconazole 400 mg orally three times daily starting on the day of surgery. Liver function tests were obtained preoperatively and after the completion of treatment.


RESULTS
Ketoconazole successfully prevented erections in all patients. None of the patients demonstrated liver function abnormalities.


CONCLUSIONS
Ketoconazole is a reliable method to prevent postoperative penile erection. With the proper monitoring of liver function tests and the avoidance of drug interactions, ketoconazole therapy also appears to be safe.
Children's Hospital and Health Center, San Diego, California.
J A
JA
Stock
G W
GW
Kaplan
D000293:Adolescent; D000328:Adult; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*
D007654:Ketoconazole