The value of a single sensitive urine pregnancy test in prediction of pregnancy outcome.
A simple and reliable indicator for pregnancy outcome will be valuable clinically for patient management and for counselling women whose pregnancies are results of subfertility treatment. This study aimed at evaluating the ICON II test, a simple semiquantitative sensitive urine pregnancy test, in predicting pregnancy outcome in women who conceived after various forms of subfertility treatment. The ICON II test was performed on day 20 after the ovulating dose of hCG administration or spontaneous LH surge. One hundred and forty-five consecutive pregnancies were studied, 99 being viable and 46 nonviable which included subclinical abortion, clinical abortion and ectopic pregnancies. There was a significant difference in the luteal serum progesterone and hCG levels between viable and nonviable pregnancies. There was also a significant difference in the ICON II test result, i.e. either weakly positive (hCG of 25-50 IU/l) and positive (hCG > 50 IU/l) and the pregnancy outcome (p < 0.0001). The specificity of a weakly positive ICON II test in predicting poor pregnancy outcome was 98.8% whereas the sensitivity was 28.6%. In conclusion, a weakly positive ICON II test is useful in predicting poor pregnancy outcome.
Department of Obstetrics and Gynaecology, University of Hong Kong.
Y F
YF
Chan
W W
WW
So
W S
WS
Yeung
E Y
EY
Lau
P C
PC
Ho
D000328:Adult; D006063:Chorionic Gonadotropin / Q000652:urine*; D005260:Female; D006801:Humans; D007246:Infertility / Q000628:therapy; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000652:urine*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011259:Pregnancy Tests, Immunologic; D012099:Reproductive Techniques; D012680:Sensitivity and Specificity
D006063:Chorionic Gonadotropin