Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis.
Cu/Zn superoxide dismutase (SOD)-like immunoreactivity (LI) was found within Lewy body-like inclusions (LBIs) in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (ALS) by using an antibody to human Cu/ZnSOD. LBIs were detected in the anterior horn cells in 10 of 20 patients with sporadic ALS. In each of these patients, 7 to 60% of LBIs showed Cu/ZnSOD-LI. No Cu/ZnSOD-LI was detected in intact neurons and glia in the 20 ALS patients, as well as in these cells in 10 normal control individuals. The skein-like inclusions and Bunina bodies, which were found in all of the 20 ALS cases, showed no Cu/ZnSOD-LI. Thus, Cu/ZnSOD appears to play roles in the production and/or degradation process of LBIs.
Department of Pathology, Tokyo Women's Medical College, Japan.
N
N
Shibata
A
A
Hirano
M
M
Kobayashi
S
S
Sasaki
T
T
Kato
S
S
Matsumoto
Z
Z
Shiozawa
T
T
Komori
A
A
Ikemoto
T
T
Umahara
D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D013116:Spinal Cord / Q000201:enzymology* / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism*
D013482:Superoxide Dismutase