[Candida endocarditis in non-addict patients: a disease with high mortality. A clinico-pathological study of 3 cases].
Candida endocarditis is a rare infection which occurs under particular epidemiological circumstances, such a drug addiction, immunosuppression, prolonged intravenous therapy and valvular replacement surgery. Diagnosis requires a high suspicious index and is based on the demonstration of the organism in cardiac vegetations, peripheral embolisms or in positive blood-cultures; also when valvular insufficiency murmurs, embolic phenomena and echocardiogram-proved vegetations are present. In spite of antifungal therapy and valvular replacement, the mortality rate in Candida endocarditis is still higher than 80%. Three new cases of the entity are here reported stressing the diagnostic and therapeutical difficulties.
Pastor
E
E
División de Enfermedades Infecciosas (Departamento de Medicina), Fundación Jiménez Díaz, Universidad Autónoma de Madrid.
Renedo
G
G
Fraile
J
J
Gadea
I
I
Fernández Guerrero
M L
ML
D000368:Aged; D001021:Aortic Valve / Q000382:microbiology / Q000473:pathology; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology / Q000473:pathology*; D004696:Endocarditis / Q000382:microbiology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000382:microbiology / Q000473:pathology; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology; D013212:Staphylococcus epidermidis
Endocarditis por Candida en pacientes no adictos: una enfermedad de gran letalidad. Estudio clínico-patológico de tres casos.