First report of t(8;21)(q22;q22) in a case of de novo acute monoblastic leukemia.
Here we describe the case of a 30-year-old man with a diagnosis of de novo acute monoblastic leukemia (FAB M5a), whose karyotype analysis revealed the presence of the translocation (8;21)(q22;q22) as the sole chromosome anomaly. In spite of the rather good prognosis patients suffering from acute leukemia and carrying this translocation are supposed to have, our patient had a very poor outcome, including an early relapse resistant to any treatment and meningeal localization. Death occurred within 5 months from diagnosis. To our knowledge this is the first report of t(8;21)(q22;q22) in de novo acute monoblastic leukemia.
Cox-Froncillo
M C
MC
Cattedra di Ematologia, 2. Università degli studi di Roma, Tor Vergata, Italy.
Genuardi
M
M
Bajer
J
J
Livdi
E
E
Adorno
G
G
Venditti
A
A
Masi
M
M
Giudiceandrea
P
P
Neri
G
G
Papa
G
G
D000328:Adult; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic