Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema.
Papaverine salicylate (MR-800) has been tested as a topical antiinflammatory agent in several models of skin inflammation in rodents, such as mouse ear dermatitis induced by croton oil, cantharidin or zymosan, and rat paw oedema induced by PAF. MR-800 exerted a dose-dependent inhibitory activity in all assays, when equimolar doses of sodium salicylate or papaverine were less effective, suggesting the existence of a favourable synergism between salicylate and papaverine.
Institute of Pharmacology, University of Catania Medical School, Italy.
E
E
de Bernardis
G
G
Leonardi
A
A
Caruso
V M
VM
Cutuli
M
M
Amico-Roxas
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002193:Cantharidin; D003436:Croton Oil; D003872:Dermatitis / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010208:Papaverine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010972:Platelet Activating Factor; D051381:Rats; D017207:Rats, Sprague-Dawley; D015054:Zymosan
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010972:Platelet Activating Factor; C091797:papaverine salicylate; D003436:Croton Oil; D015054:Zymosan; D010208:Papaverine; D002193:Cantharidin