[Effects of chloroform, chlorobenzene and polychlorinated biphenyls on erythrocyte lipid peroxidation and membrane fluidity in poisoned rabbits].
Effects of three chlorinated compounds, i.e., chloroform, chlorobenzene and Aroclor 1254 (PCBs), on lipid peroxidation and membrane fluidity of erythrocytes in poisoned rabbits were studied. Results revealed daily intraperitoneal injection of peanut oil containing chlorinated compounds into rabbits showed nonenzymic promotion effects on its erythrocyte lipid peroxidation in varying degrees, but different effects on erythrocyte membrane fluidity, promoting by chloroform and inhibiting by Aroclor 1254. It suggested the constitutional characteristics of toxicant molecules also had effects on membrane fluidity. In addition, it was found there existed potential relationship between maintenance of cell morphology and membrane fluidity.
Xue
J H
JH
Naval Medical Research Institute PLA of China, Shanghai.
Wang
J Z
JZ
Xin
P Z
PZ
D000818:Animals; D002722:Chlorobenzenes / Q000633:toxicity*; D002725:Chloroform / Q000633:toxicity*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008560:Membrane Fluidity / Q000187:drug effects*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011817:Rabbits
D002722:Chlorobenzenes; D008315:Malondialdehyde; D002725:Chloroform; D011078:Polychlorinated Biphenyls