Aromatase activity in an estrogen-producing adrenocortical carcinoma in a young man.
We report on a 19-year-old man with adrenocortical adenoma producing an excessive amount of estrogen. Determination of aromatase activity of the carcinoma tissue revealed its marked enhancement compared with that of 3 normal adrenal glands and the adipose tissue. The enhanced activity of aromatase was mainly responsible for the overproduction of estrogen in the adrenocortical carcinoma of our case.
Department of Urology, Sapporo Medical University School of Medicine, Japan.
M
M
Kimura
N
N
Itoh
T
T
Tsukamoto
Y
Y
Kumamoto
Y
Y
Takagi
Y
Y
Mori
D000306:Adrenal Cortex Neoplasms / Q000201:enzymology* / Q000378:metabolism; D018268:Adrenocortical Carcinoma / Q000201:enzymology* / Q000378:metabolism; D000328:Adult; D001141:Aromatase / Q000378:metabolism*; D004967:Estrogens / Q000096:biosynthesis*; D006801:Humans; D008297:Male
D004967:Estrogens; D001141:Aromatase