Genetic determinants of arterial thrombosis.
This chapter describes examples of genetic variation determining plasma levels of three independent risk factors for arterial thrombotic disease, namely fibrinogen, coagulation factor VII and plasminogen activator inhibitor type 1, together with a discussion of the underlying molecular mechanisms. In each case, the data suggest that there is interaction between genotype and environment in determination of the relevant plasma level, providing a possible explanation for the differential response of different individuals to their environment.
Green
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Department of Medicine, UCL Medical School, Rayne Institute, London, UK.
Humphries
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D000347:Afibrinogenemia / Q000097:blood / Q000150:complications / Q000235:genetics; D001158:Arteries; D004777:Environment; D005167:Factor VII / Q000235:genetics; D005168:Factor VII Deficiency / Q000097:blood / Q000150:complications / Q000235:genetics; D015241:Fibrinogens, Abnormal / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000235:genetics; D007375:Interleukin-1 / Q000494:pharmacology; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology; D017395:Plasminogen Activator Inhibitor 1 / Q000172:deficiency / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000187:drug effects; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics*
D015241:Fibrinogens, Abnormal; D007375:Interleukin-1; D017395:Plasminogen Activator Inhibitor 1; D005167:Factor VII