Role of histamine in regulation of blood flow in the injured gastric mucosa of the cat.
Superficial mucosal damage caused by a mild irritant (2 M NaCl) results in release of histamine and probably prostaglandins giving increased GMBF. This hyperemic response contributes to protect the mucosa during the early phase of repair after damage by supplying the mucosa with bicarbonate and by eliminating back diffusing acid and other toxic substances such as ethanol. We conclude that histamine plays an important role in the blood flow regulation in the stomach.
Gislason
H
H
Surgical Research Laboratory, University of Bergen, Norway.
Svanes
K
K
D000818:Animals; D002415:Cats; D005753:Gastric Mucosa / Q000098:blood supply* / Q000293:injuries*; D006632:Histamine / Q000502:physiology*; D012039:Regional Blood Flow
D006632:Histamine