[The cellular level of integration in the body of the workers at a poultry plant with extrinsic allergic alveolitis].
Studied at the cell level of integration were the following indices for nonspecific reactivity: phagocytic activity of leucocytes (PhAL), a parameter characterizing damage to neutrophils (PDN), nitroblue tetrasolium test (NBT-test), the activity of alkaline phosphatase (AlPhA) of neutrophils, and the activity of acid phosphatase (AcPhA) of lymphocytes in EAA (exogenous allergic alveolitis) workers with reference to the service duration. PDN was shown to be raised in EAA workmen who had worked at the integrated poultry farm for 6-10 and 16-20 years. The parameter characterizing damage to neutrophils did not differ from control values in the workmen with 1-5 and 11-15 yr service duration. It was found that the activity of AlPh of neutrophils was decreased in EAA workers with 1-5 and 11-15 yr service duration. The activity of AlPh did not change with 6-10- and 16-20 yr service duration. The results from NBT-test, determinations of PhAL, and the activity of AcPh of lymphocytes showed their elevation in EAA workmen with the service duration 1-20 years. In summary, study at the cell level of integration into the indices of nonspecific reactivity in workmen with 1-2-yr length of service showed a decrease in the activity of AlPh neutrophils and an increase in the activity of AcPh of lymphocytes, PhAL, PDN, NBT-test, suggesting some disturbance in metabolism in leucocytes and involvement of nonspecific mechanisms of protection of organism in EAA.
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D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D008297:Male; D008462:Meat-Packing Industry; D008875:Middle Aged; D009784:Occupational Diseases / Q000276:immunology*; D011202:Poultry Products; D014455:Ukraine
Doslidzhennia klitynnoho rivnia intehratsiï orhanizmu robotnykiv ptakhofabryky pry ekzohennomu alerhichnomu al'veoliti.