Vitamin A ameliorates the genotoxicity in mice of aflatoxin B1-containing Aspergillus flavus infested food.
Young weaning Swiss albino mice were orally administered crude aflatoxin B1 in a dose mimicking human exposure condition, i.e. at 0.05 micrograms/kg body weight/day for 14 weeks. Vitamin A (retinol) was orally administered along with the toxin in double (132 IU/kg body wt/day) the human equivalent therapeutic dose. The results suggested that vitamin A minimised the frequency of toxin-induced clastogeny in both mitotic and meiotic chromosomes. The decreases in sperm count as well as increases in abnormality in the gross morphology of the sperm-head, as observed upon toxin treatment, was ameliorated by the vitamin A.
Sinha
S P
SP
Department of Zoology, Bhagalpur University, India.
Dharmshila
K
K
D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000737:chemistry*; D002869:Chromosome Aberrations; D005260:Female; D005516:Food Microbiology; D006801:Humans; D008297:Male; D008540:Meiosis; D051379:Mice; D015162:Micronucleus Tests; D008938:Mitosis; D013076:Sperm Count / Q000187:drug effects; D013077:Sperm Head / Q000187:drug effects; D014801:Vitamin A / Q000494:pharmacology*
D016587:Antimutagenic Agents; D014801:Vitamin A; D016604:Aflatoxin B1