Immunocytochemical studies on pancreatic endocrine cells at early stages of development of the pig.
The studies were performed on pig embryos between 23rd and 31st day of intrauterine life. Immunocytochemical markers of neuroendocrine cells, i.e. neuron-specific enolase, chromogranin and synaptophysin as well as basal hormones, i.e. insulin, glucagon, somatostatin, pancreatic polypeptide and, additionally, serotonin and gastrin were detected in serial sections. Our studies indicate that differentiation of pancreatic endocrine cells does not take place unitemporally. At the first stage, the cells acquire the traits of neuroendocrine cells and secrete more than one hormone while final specialization toward cells secreting individual hormones take places at a later stage.
Department of Histology and Embryology, Medical Academy, Poznań, Poland.
M
M
Zabel
J
J
Surdyk-Zasada
I
I
Lesisz
E
E
Jagoda
T
T
Wysocka
J
J
Seidel
J
J
Grzeszkowiak
D000818:Animals; D002454:Cell Differentiation; D005260:Female; D006728:Hormones / Q000378:metabolism; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D010187:Pancreatic Hormones / Q000378:metabolism; D011247:Pregnancy; D013552:Swine
D006728:Hormones; D010187:Pancreatic Hormones