[An experimental evaluation of the cutaneous action of the preparation Bulmektin].
The acute and subacute dermal toxicity, skin irritating and sensitizing effect of the preparation "Bulmektin" was examined for a period of 21 days. It contains 0.5% active substance Ivermectin. The experiments were carried out in conformity with the Bulgarian State Standards and the OECD methodical recommendations. The unrepeated dermal application of the preparation in dose 6000 mg/kg-1 for white rats provoked no lethality and signs of intoxication. No cumulative effect was established at the 21-day dermal toxicity. The threshold dose is 2000 mg/kg-1. On the basis of the investigations could be accepted, that the preparation carries no danger for acute and chronic dermal intoxications at observing the regulations for its production and use. No local irritation of the skin is established in rats and guinea pigs from the preparation. There is no development of contact allergy at the application of induced and allowed dose of 25% aqua suspension of the preparation on white guinea pigs.
Zh
Zh
Khalkova
D000818:Animals; D000871:Anthelmintics / Q000633:toxicity*; D001769:Blood / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000633:toxicity; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects; D013997:Time Factors
D000871:Anthelmintics; D007559:Ivermectin; C019264:avermectin
Eksperimentalna otsenka na kozhnoto deĭstvie na preparata "Bulmektin".