Effect of immunomodulation on the course of experimental toxocariasis in mice.
Immunosuppressed groups treated with cortisone showed fulmination of Toxocara canis infection in terms of significant increase in brain parasitism, total larval count and significant decrease in the percentage reduction of the total count. Suppression of the host inflammatory responses was detected in the liver, lungs, brain and muscles. Accelerated transit of larvae through the liver was observed when cortisone was given before infection. Whether BCG was given before or after infection, it showed no significant changes regarding all criteria compared to the control group. Induction of diabetes, whether before or after infection, led to persistence of larvae in the liver, insignificant increase in brain and total larval parasitism and insignificant decrease in the percentage reduction of the total count.
Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
N H
NH
Mohamed
S A
SA
Soffar
N M
NM
Sabry
K M
KM
Makled
N M
NM
Otifa
D000818:Animals; D001500:BCG Vaccine; D001921:Brain / Q000469:parasitology; D003348:Cortisone; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D005260:Female; D007114:Immunization; D007165:Immunosuppression Therapy; D007814:Larva / Q000276:immunology; D008099:Liver / Q000469:parasitology; D051379:Mice; D014119:Toxocara / Q000276:immunology; D014120:Toxocariasis / Q000150:complications / Q000276:immunology*
D001500:BCG Vaccine; D003348:Cortisone