beta 2-Glycoprotein I-dependent and -independent anticardiolipin antibodies in healthy pregnant women.
The purpose of this study was to determine the association between beta 2-glycoprotein I (beta 2GPI)-dependent anticardiolipin antibodies (aCL) and beta 2GPI-independent aCL and their respective relevance to adverse pregnancy outcomes. Therefore, we prospectively studied 210 normal pregnant women, utilizing a modified enzyme-linked immunosorbent assay method for beta 2GPI-dependent and -independent aCL. Seven of the 210 pregnant women (3.3%) demonstrated evidence for beta 2GPI-independent immunoglobulin G (IgG)-aCL. Two patients, who also appeared positive for beta 2GPI-dependent IgG-aCL, were proven to be false positives. Amongst the 210 patients, not one was thus positive for beta 2GPI-dependent aCL. Women with beta 2GPI-independent aCL demonstrated no adverse pregnancy outcomes. These results suggest that the presence of beta 2GPI-independent aCL is not associated with the presence of beta 2GPI-dependent aCL, though it may give rise to false positive results. Since the presence of beta 2GPI-independent aCL does not appear to be associated with adverse pregnancy outcomes, beta 2GPI-dependent assays may represent better markers of miscarriage risk.
Department of Obstetrics and Gynaecology, Nagoya City University Medical School, Japan.
K
K
Aoki
E
E
Matsuura
H
H
Sasa
Y
Y
Yagami
A B
AB
Dudkiewicz
N
N
Gleicher
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D001053:Apolipoproteins; D005260:Female; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D011247:Pregnancy / Q000276:immunology*; D011446:Prospective Studies; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D001053:Apolipoproteins; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I