Plasticity of excitatory synaptic transmission in kitten visual cortex depends on voltage-dependent Ca2+ channels but not on NMDA receptors.
Long-term potentiation (LTP) of excitatory synaptic transmission occurs in in vitro slices of cat and rat visual cortex. Earlier studies suggested that activation of N-methyl-D-aspartate (NMDA)-selective glutamate receptors is essential for the induction of LTP. However, our studies on kitten visual cortex demonstrate that LTP induction requires the activation of low-threshold Ca2+ channels in postsynaptic cells but not of NMDA receptors.
Komatsu
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Department of Physiology, Kyoto Prefectural University of Medicine, Japan.
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D002415:Cats; D004594:Electrophysiology; D017774:Long-Term Potentiation / Q000502:physiology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*
D015220:Calcium Channels; D016194:Receptors, N-Methyl-D-Aspartate