Hereditary nephrotic syndrome with progression to renal failure in a mouse model (ICGN strain): clinical study.
The clinical course of murine hereditary nephrotic syndrome (ICGN strain) was determined by examining 201 animals under different conditions. In the early stage, significant hypoproteinemia and hypoalbuminemia developed (p < 0.001) in parallel with a progressive rise in urinary protein concentration (p < 0.001). In the middle stage, the concentrations of total cholesterol, triglyceride, and beta-lipoprotein markedly increased (p < 0.01, p < 0.001, and p < 0.001, respectively), suggesting that type IIb hyperlipoproteinemia developed as in human nephrotic patients. Systemic edema appeared in 8 of 24 animals. In the terminal stage, both BUN and creatinine values greatly increased (p < 0.001), indicating rapid deterioration of renal function. The present study suggests that ICGN mice could be a useful model to study the pathophysiology of human nephrotic syndrome and its progression to renal failure.
Ogura
A
A
Department of Veterinary Science, National Institute of Health, Japan.
Asano
T
T
Suzuki
O
O
Yamamoto
Y
Y
Noguchi
Y
Y
Kawaguchi
H
H
Yamaguchi
Y
Y
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D004487:Edema / Q000209:etiology / Q000378:metabolism; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
D001798:Blood Proteins