Evolution of immunological abnormalities in HIV infection by vertical transmission.
Forty-four children infected through vertical transmission, from a total of 146 born to HIV-positive mothers, were studied. Immunological data were analysed and compared with those of the noninfected children. Two transmission patterns emerge from the clinical and immunological characteristics: (i) infants infected during pregnancy with severe immunodeficiency and clinical manifestations before the age of 1 year, and (ii) children probably infected perinatally, who have better clinical outcome. Immunological data are important for prognosis and early therapeutic protocols to be established.
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Immunology Unit, C.S. Valle Hebrón, Barcelona, Spain.
Caragol
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Bertran
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D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology; D006679:HIV Seropositivity / Q000276:immunology* / Q000635:transmission; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D007375:Interleukin-1 / Q000097:blood / Q000276:immunology; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology; D009035:Mothers; D011379:Prognosis; D012720:Severity of Illness Index
D015483:HIV Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1; D007376:Interleukin-2; D007371:Interferon-gamma