Diagnosis and treatment of patients with "frontal lobe" syndromes.
Nine case descriptions illustrate the three major prefrontal syndromes seen in clinical practice: disorganized type, disinhibited type, and apathetic type. A mixture of symptoms from each subtype is usually seen, but dysfunction in one prefrontal system often dominates. A careful history and examination are essential for accurate diagnosis. A complete history can rarely be elicited from the patient alone. Structural brain imaging, especially MRI, and neuropsychological testing are key to the diagnostic workup. EEG, video-EEG, and functional brain imaging can be valuable in the evaluation of possible partial complex seizures of frontal lobe origin and other atypical frontal lobe disorders. Effective treatment requires educating the patient and the family about the illness and modulating environmental factors that influence the patient's behavior. Judicious use of psychoactive medication may be helpful, but adverse effects are common.
Department of Neurology and Psychiatry, Brown University School of Medicine, Providence, Rhode Island.
S P
SP
Salloway
D000328:Adult; D000368:Aged; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D001931:Brain Mapping; D003131:Combined Modality Therapy; D003704:Dementia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D009483:Neuropsychological Tests; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use; D013577:Syndrome
D011619:Psychotropic Drugs