Hyperaggregation of platelets in intestinal tuberculosis: role of platelets in chronic inflammation.
Eighty-eight percent (38/43) patients of intestinal tuberculosis showed significant hyperaggregation of platelets (P < 0.001). Serum and plasma from 15 patients when incubated with normal platelets caused hyperaggregation. Gel filtered platelets from 2 patients suspended in normal plasma showed hyperaggregation of platelets with arachidonic acid. Tubercular protein had no effect on platelet aggregation. A role of hyperactive platelets in chronic inflammatory response is discussed.
Sarode
R
R
Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Bhasin
D
D
Marwaha
N
N
Roy
P
P
Singh
K
K
Panigrahi
D
D
Garewal
G
G
Mehta
S K
SK
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D014385:Tuberculosis, Gastrointestinal / Q000097:blood* / Q000503:physiopathology