Age-specific prevalence of antibodies to hepatitis A and E viruses in Pune, India, 1982 and 1992.
The age-specific seroprevalence of antibody to hepatitis A virus (HAV) and antibody to hepatitis E virus (HEV) were studied in persons in Pune, India, where both viruses are endemic. The data showed that HAV infected the majority of persons by age 3 years and virtually 100% by late childhood. In contrast, infection with HEV was rare in children and did not reach peak prevalence (33%-40%) until early adulthood. The reason for the differences in infection rates between HAV and HEV is not known. Age-specific antibody patterns in serum samples obtained 10 years apart show that neither HAV nor HEV has diminished in medical importance in this Indian community.
Arankalle
V A
VA
National Institute of Virology, Indian Council of Medical Research, Pune.
Tsarev
S A
SA
Chadha
M S
MS
Alling
D W
DW
Emerson
S U
SU
Banerjee
K
K
Purcell
R H
RH
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology* / Q000276:immunology; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000097:blood*; D016751:Hepatitis E / Q000453:epidemiology* / Q000276:immunology; D016752:Hepatitis E virus / Q000276:immunology*; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D013997:Time Factors
D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies