Specific thrombopoietin cloned and sequenced--with personal retrospect and clinical prospects.
Description of some properties, and nomination of human thrombopoietin (TP) had already occurred in Hungary, in 1958. In 1994 five laboratories (three in USA, one in France and one in Japan) independently published clonal purification, sequencing, and chromosomal localization of TP. This breakthrough now approaches therapeutic use in humans.
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Kelemen
D000818:Animals; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D013926:Thrombopoietin / Q000235:genetics / Q000627:therapeutic use*
D011994:Recombinant Proteins; D013926:Thrombopoietin