Subtype of insulin-dependent diabetes mellitus (IDDM) in Japan: slowly progressive IDDM--the clinical characteristics and pathogenesis of the syndrome.
A prospective observation on the natural history of beta-cell function in islet cell antibody (ICA)-positive NIDDM disclosed characteristic findings of slowly progressive IDDM distinct from those of acute onset IDDM. The characteristic features includes: (1) late onset; (2) slow progression of beta-cell failure over several years with persistently positive low-titer ICA; (3) incomplete beta-cell loss; (4) frequent involvement of exocrine pancreas; (5) higher family history of NIDDM; and (6) association with some genetic predisposition including HLA-DQA1*0301-DQB1*0401 and/or mitochondrial gene mutation at nucleotide pair 3243.
Department of Endocrinology and Metabolism, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
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Kobayashi
D000208:Acute Disease; D001323:Autoantibodies / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000145:classification* / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D018450:Disease Progression; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007564:Japan / Q000453:epidemiology; D011446:Prospective Studies; D013577:Syndrome
D001323:Autoantibodies; D006680:HLA Antigens; C024211:islet cell antibody