[New tumor suppressor genes intervening in the regulation of the cycle].
Eukaryotic cell cycle progression is governed by multiple cyclin and cyclin-dependent kinases interactions that are in turn regulated by multiple factors. Recently, inhibitors of cyclin/cyclin-dependent kinases activities have been characterized and their genes have been cloned. Alterations of some these genes may play a major in tumor initiation or progression.
Grandchamp
B
B
INSERM U409, Faculté Xavier Bichat, Paris, France.
D002453:Cell Cycle / Q000235:genetics*; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D016147:Genes, Tumor Suppressor; D006801:Humans
D018844:Cyclin-Dependent Kinases
De nouveaux gènes suppresseurs de tumeurs intervenant dans la régulation du cycle cellulaire.