[Magnetic resonance spectroscopy in fibromyalgia. A study of phosphate-31 spectra from skeletal muscles during rest and after exercise].
31phosphorus nuclear magnetic resonance (31P NMR) spectroscopy of painful calf muscle was performed in 12 patients with fibromyalgia and 7 healthy subjects during rest, aerobic and anaerobic exercising conditions, and postexercise recovery. Ratios of inorganic phosphate and creatine phosphate (Pi/PCr) and pH were calculated from the collected 31P NMR spectra. Resting values of Pi/PCr were normal in the patients. Patients only tolerated 49% of the workload tolerated by the controls (P = 0.005). Patients and controls had similar rates of Pi/PCr and pH changes during work and recovery. The controls were able to change their Pi/PCr and pH more than the patients, due to the greater workload reached. However, statistical significance was only reached for the anaerobic static exercise (P = 0.003). It was concluded that fibromyalgia patients have a reduced voluntary capacity for work, but with a biochemical response to work and recovery similar to healthy subjects.
Reumatologisk afdeling, Hvidovre Hospital, København.
S
S
Jacobsen
K E
KE
Jensen
C
C
Thomsen
B
B
Danneskiold-Samsøe
O
O
Henriksen
D000328:Adult; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D005356:Fibromyalgia / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus; D012146:Rest
D010710:Phosphates; D010725:Phosphocreatine; D010758:Phosphorus
Magnetisk resonans-spektroskopi ved fibromyalgi. En undersøgelse af fosfat-31 spektra fra skeletmuskulaturen i hvile, under og efter arbejde.