Humulon, a bitter in the hop, inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Humulon, one of the bitters in the hop, was isolated from the female flowers of Humulus lupulus. This component has inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. At 1 mg/mouse, humulon inhibited markedly the tumor-promoting effect of TPA (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 micrograms/mouse). Furthermore, humulon inhibited arachidonic acid-induced inflammatory ear edema in mice.
College of Pharmacy, Nihon University, Chiba, Japan.
K
K
Yasukawa
M
M
Takeuchi
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M
Takido
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016718:Arachidonic Acid; D053138:Cyclohexenes; D004354:Drug Screening Assays, Antitumor; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013729:Terpenes / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate
D053138:Cyclohexenes; D013729:Terpenes; D016718:Arachidonic Acid; D015127:9,10-Dimethyl-1,2-benzanthracene; C007966:humulon; D013755:Tetradecanoylphorbol Acetate