[A new method for assessment of mental performance during simultaneous, quantitative, topographical electroencephalometry and psychometry in pharmacology. Proof of the effect of a combination of biogenic amines, vitamins, minerals and trace elements].
Assessment of the Mental Performance during Simultaneous Quantitative Topographical Electroencephalometry and Psychometry in Pharmacology/Proof of influence of a biogenic amine-vitamin combination. The aim of this study was to verify the effect of a combination medicine (Vita-Gerin-Geistlich) on the human EEG pattern during psychometric (cognitive) tests given to 43 patients with poor concentration and thinking problems. A randomised, parallel, placebo-controlled double-blind study was performed. Applying 17-channel quantitative electroencephalometry and psychometric tests simultaneously this study revealed a test-dependent increase in absolute spectral EEG power in the delta and theta frequency bands, mainly observed in the frontotemporal cortex. After 8 weeks the increase in EEG power differed significantly with respect to taking placebo and verum (1 capsule/day). Verum caused a stronger rise in spectral delta and theta power, the psychometric test performance also improved. Both effects could be verified statistically. The novel EEG-controlled psychometric test set (enabling artefact-free EEG recording during psychometric tests) which was developed and used in this study represents a valid tool for future pharmacological research.
Pro Science Private Research Institute GmbH, Linden.
F
F
Schober
R
R
Schellenberg
W
W
Dimpfel
D000328:Adult; D000368:Aged; D001679:Biogenic Amines / Q000494:pharmacology*; D001931:Brain Mapping; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy / Q000523:psychology; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000494:pharmacology*; D011594:Psychometrics; D014131:Trace Elements / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology*
D001679:Biogenic Amines; D008903:Minerals; D014131:Trace Elements; D014815:Vitamins
Neue Wege zur Beurteilung der mentalen Leistungsfähigkeit mittels simultaner topographischer Elektroenzephalometrie und Psychometrie in der Pharmakologie. Nachweis des Einflusses einer Wirkstoffkombination aus biogenem Amin, Vitaminen, Mineralstoffen und Spurenelementen.