The effect of aspirin on neurodeficit and platelet aggregability in acute ischemic cerebral strokes.
We examined the role of aspirin in modifying platelet aggregability (PA) and neurodeficit (ND) in patients presenting within 48 hours of acute ischemic cerebral strokes of the carotid territory. 28 adult patients were studied at baseline and after 7 days of treatment with a single daily dose of aspirin 325mg (group A, n = 12) and 160 mg (Group B, n = 16). We also evaluated the neurologic outcome at the beginning and at the end of 7 days using a scoring system. There was no significant difference in the ND scores and in vitro PA between these two groups. PA, as measured in vitro, does not appear to have any significant role as a predictor of neurologic outcome in acute ischemic strokes. The change in ND scores of patients with ischemic cerebral strokes treated acutely with aspirin was not significant upto first 7 days therapy.
Department of Neurology, King Edward VII Memorial Hospital, Bombay.
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Chaudhuri
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Medhekar
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D016893:Carotid Stenosis / Q000097:blood / Q000188:drug therapy; D002544:Cerebral Infarction / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*
D001241:Aspirin