Potential applications of apoptosis in modifying the biological behavior of therapeutically refractory cancers.
Recent information about apoptosis or programmed cell death, the anti-apoptotic gene, BCL2, its interaction with reactive oxygen species and the role of these agents in senescence and apoptosis, suggests a discussion of their relationships could be of interest. Such information may eventually provide alternative approaches to modifying the biological behavior of therapeutically resistant cancers. Some of these comments probably are self-evident, others may be less so and provide ideas for further studies.
Anderson
K M
KM
Department of Medicine, Rush Medical College, Chicago, IL 60612.
Harris
J E
JE
Bonomi
P
P
D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D002454:Cell Differentiation; D002675:Child, Preschool; D004351:Drug Resistance; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology* / Q000628:therapy; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species / Q000378:metabolism
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species