Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection.
Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin.
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
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Hülsken
J
J
Behrens
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W
Birchmeier
D025601:Adenomatous Polyposis Coli Protein; D000818:Animals; D051186:Armadillo Domain Proteins; D015820:Cadherins / Q000235:genetics / Q000502:physiology*; D002448:Cell Adhesion / Q000235:genetics* / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000502:physiology; D004330:Drosophila; D029721:Drosophila Proteins; D017491:Genes, APC; D016147:Genes, Tumor Suppressor; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology; D009361:Neoplasm Invasiveness; D011506:Proteins / Q000235:genetics / Q000502:physiology; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin
C495305:ARM protein, Drosophila; D025601:Adenomatous Polyposis Coli Protein; D051186:Armadillo Domain Proteins; C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; D011506:Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin