[A case of subcutaneous sarcoid nodules induced by interferon-alpha].
A 57-year-old woman came to our hospital complaining of multiple subcutaneous nodules that developed while she received corticosteroid therapy for pulmonary sarcoidosis. She was treated with interferon-alpha (IFN-alpha) at another hospital for C-type chronic hepatitis and she noticed these nodules with tenderness two months after treatment began. A biopsy specimen of the nodule revealed subcutaneous sarcoid granuloma. Her abnormally high serum-ACE value and subcutaneous nodules resolved after the dose of IFN-alpha was gradually reduced. IFN therapy should be used with care in cases of sarcoidosis in which IFN-gamma and T-lymphocytes are mainly involved.
Fourth Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan.
I
I
Ohhata
T
T
Ochi
S
S
Kurebayashi
H
H
Masutani
M
M
Kikui
D005260:Female; D006526:Hepatitis C / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008875:Middle Aged; D012507:Sarcoidosis / Q000139:chemically induced*; D012871:Skin Diseases / Q000139:chemically induced*
D016898:Interferon-alpha