[Changes in and significance of atrial natriuretic peptide, angiotensin II after experimental brain injury].
We used the method of RIA determined the contents of atrial natriuretic peptide (ANP), angiotensin II (ANG II) in plasma and brain tissues after brain injury in 70 rats. The results showed that the ANP was significantly decreased in brain tissues on 6, 72 hours after brain injury. At the same time, the plasma and brain tissues ANG II, brain water contents were significantly increased. The results suggested that the unbalance of ANP and ANG II may be related to the pathophysiological process of brain edema.
Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an.
Z W
ZW
Zhang
S Y
SY
Yi
X
X
Zhang
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000804:Angiotensin II; D009320:Atrial Natriuretic Factor