[Convulsions associated with the administration of excessive dose of ceftazidime in patients with renal failure].
Central neurological diseases caused by beta-lactamins are usually associated with excessive dosages in patients with renal failure. Two case reports of convulsive encephalopathy in patients treated with ceftazidime, show the absolute necessity of adapted posology, in case of renal dysfunction. In one case, we could follow plasma levels of ceftazidime during hemodialysis, and calculated the pharmacokinetic parameters. We conclude that extra renal epuration is an efficient technique in case of acute ceftazidime intoxication.
Service de Pharmacologie clinique, CHU Amiens.
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E
Chetaille
K
K
Masmoudi
L
L
Dimier-David
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L
Hary
J L
JL
Schmit
M
M
Andrejak
D000368:Aged; D002442:Ceftazidime / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D051437:Renal Insufficiency / Q000150:complications*; D012640:Seizures / Q000139:chemically induced*
D002442:Ceftazidime
Crises convulsives associées à l'administration de doses excessives de ceftazidime chez des patients en insuffisance rénale.