A simple method of correlating pharmacodynamic equivalence with absolute bioavailability following noninvasive delivery of insulin.
Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907-1336.
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D000818:Animals; D001682:Biological Availability; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D007442:Intubation, Intratracheal; D007601:Jugular Veins; D008168:Lung / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013810:Therapeutic Equivalency
D001786:Blood Glucose; D007328:Insulin