[Clinical and experimental studies of the dynamic changes in neuropeptides after trauma].
Dynamic changes of contents of beta-endorphin, leu-enkephalin and oxytocin in plasma were determined in seventeen fracture patients with shock, fascial space syndromes, or infection postoperation. There was significant rise of contents in beta-endorphin and leu-enkephalin but not in oxytocin after trauma, Of those accompanied by infection postoperation, beta-endorphin and oxytocin remained high. The contents of beta-endorphin and enkephalin decreased gradually in non-infectious group, but were still higher than normal. The most obvious change was seen in beta-endorphin, suggesting that beta-endorphin plays a more important role in trauma. This was also confirmed in rat injury model.
Hong
X R
XR
Changhai Hospital, Second Military Medical College, Shanghai.
Li
M
M
Cao
J Z
JZ
D000818:Animals; D004743:Enkephalin, Leucine / Q000097:blood; D050723:Fractures, Bone / Q000097:blood*; D006801:Humans; D008297:Male; D009104:Multiple Trauma / Q000097:blood*; D010121:Oxytocin / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012774:Shock, Traumatic / Q000097:blood / Q000209:etiology; D001615:beta-Endorphin / Q000097:blood*
D010121:Oxytocin; D004743:Enkephalin, Leucine; D001615:beta-Endorphin