Inhibitors of protein tyrosine kinase pp60v-src: sterol sulfates from the brittle star Ophiarachna incrassata.
Bioactivity-guided fractionation of the extracts of the green brittle star Ophiarachna incrassata using a protein tyrosine kinase pp60v-src inhibition assay led to the isolation of a new sterol sulfate [2] together with four known ones (1,3-5). All five compounds were found to inhibit protein tyrosine kinase pp 60v-src.
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019.
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Fu
F J
FJ
Schmitz
R H
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Lee
J S
JS
Papkoff
D L
DL
Slate
D000818:Animals; D001358:Avian Sarcoma Viruses; D002461:Cell Line, Transformed; D004447:Echinodermata; D015394:Molecular Structure; D015688:Oncogene Protein pp60(v-src) / Q000037:antagonists & inhibitors*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013464:Sulfuric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014020:Tissue Extracts
D013261:Sterols; D013464:Sulfuric Acids; D014020:Tissue Extracts; D011505:Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src)