A suggested mechanism for aluminum biotoxicity.
Following earlier work on the relevance of silica (SiO2) and fluoride (F) to the biotoxicity of aluminum (Al), it is shown that relatively high risks of a measure of mental impairment are frequently associated with relatively low SiO2 and F in the drinking water available in different parts of Ontario. Also, because of a negative association between SiO2 and F concentrations in the treated water available in different municipalities, a low SiO2 concentration can account for the observed association involving high F concentrations, and low F concentrations can similarly account for associations involving high SiO2 concentrations. In the light of these observations, the biotoxic effects at low Al concentrations can be explained by assuming that interactions occur with membranes. Such interactions may be less likely at higher SiO2 and F concentrations, because at these concentrations, interactions between Al-, SiO2- and F-containing species are more important. Generally, the various associations with a measure of mental impairment can be explained on the assumption that F exerts a protective effect against the biotoxic effects of Al, as does SiO2 under certain conditions, but the effects of SiO2 only become important at higher SiO2 concentrations. The results from this and other studies suggest that the neurotoxic effects of Al depend on other water constituents. The results also indicate that absorption through the lung or skin, rather than through the stomach or the bowel, can better explain the reported associations.
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Statistics Canada, Health Statistics Division, Ottawa, Ontario.
Agwani
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D000535:Aluminum / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D000544:Alzheimer Disease / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005461:Fluorine / Q000008:administration & dosage*; D006801:Humans; D009864:Ontario; D012822:Silicon Dioxide / Q000008:administration & dosage*; D014867:Water / Q000008:administration & dosage; D014881:Water Supply
D014867:Water; D005461:Fluorine; D012822:Silicon Dioxide; D000535:Aluminum