The usefulness of nimodipine, an L-calcium channel antagonist, in the treatment of tinnitus.
Thirty-one patients were drawn from a tinnitus clinic, screened for other medical problems and treated for 4 weeks with 30 mg nimodipine four times daily. Before and after treatment, the intensity of their tinnitus was assessed subjectively on a scale 1-10. Five patients reported to have a great improvement in their tinnitus whilst two claimed a worsening of the condition. Of the five positive responders, four were treated further with 30 mg nimodipine per day for 4 weeks and 60 mg per day for a further 4 weeks. During this treatment they were assessed more objectively by the determination of the minimal masking level using narrow band noise. There was a good correlation between the subjective and objective assessment of their responses.
Davies
E
E
Department of Pharmacology, University of Birmingham, UK.
Knox
E
E
Donaldson
I
I
D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D009553:Nimodipine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D009622:Noise; D010470:Perceptual Masking; D014012:Tinnitus / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D009553:Nimodipine