Polymorphic tandem repeats in dopamine D4 receptor are spread over primate species.
The human dopamine D4 receptor has polymorphic tandem repeats in the third cytoplasmic loop. However, these repeats are not present in the rat counterpart. To determine whether the tandem repeats are specific to humans or not, we analyzed genomic DNA sequences for the D4 receptor of six primate species (human, chimpanzee, gorilla, orangutan, macaque, marmoset). Sequencing data revealed that all primates have the 48-bp tandem repeats in the D4 receptor gene. This finding suggests that these repeats originated before the separation of the New World monkey lineage from the Old World monkey and ape-human lineages.
Neuroscience & Gastrointestinal Research Lab., Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd., Ibaraki, Japan.
M
M
Matsumoto
K
K
Hidaka
S
S
Tada
Y
Y
Tasaki
T
T
Yamaguchi
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002144:Callithrix / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D006071:Gorilla gorilla / Q000235:genetics; D015186:Hominidae / Q000235:genetics; D006801:Humans; D008252:Macaca fascicularis / Q000235:genetics; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011148:Pongo pygmaeus / Q000235:genetics; D011323:Primates / Q000235:genetics*; D011954:Receptors, Dopamine / Q000235:genetics*; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D017931:DNA Primers; C493599:DRD4 protein, human; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D004247:DNA