Dose-response analysis using spreadsheets.
The task of fitting dose-response models to experimental data can be performed using a spreadsheet with a built-in optimization engine. This paper shows how the task of point and interval estimation can be performed using Microsoft EXCEL. A case study is presented on the carcinogenic dose-response behavior of chloroform.
Department of Civil and Architectural Engineering and Environmental Studies Institute, Drexel University, Philadelphia, Pennsylvania 19104.
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Haas
D000818:Animals; D002725:Chloroform / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008432:Mathematical Computing; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D018570:Risk Assessment; D012984:Software
D002725:Chloroform