Prostaglandins and progesterone receptor antagonists in human fertility regulation.
Anti-progesterone medicines have now been extensively studied for human fertility regulation. The combination of the anti-progesterone Mifepristone with prostaglandin analogues such as Gemeprost and Misoprostol have been used in several European centres for medical abortion. Used before nine weeks gestation, these medicines have similar efficacy to surgical abortion. In addition, administration of progesterone antagonists within five days of unprotected intercourse appear effective in pregnancy prevention. Anti-progesterone medicines are not currently available in Australia. The introduction of progesterone receptor antagonists and modern prostaglandins would save approximately $10,000,000 per year to the Australian Health Budget. Furthermore, the introduction of progesterone receptor antagonists for emergency contraception would have even greater financial and emotional savings for Australian women. In Australia, when known carcinogens can be purchased over the counter, it is surely time for Australians to consider effective emergency contraception bought over the counter.
Monash University, Department of Obstetrics and Gynaecology, Clayton, Victoria.
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Healy
D000028:Abortion, Induced / Q000191:economics; D001315:Australia; D005260:Female; D005298:Fertility / Q000502:physiology*; D017048:Health Care Costs; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology*; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors*; D016387:Women's Health
D011453:Prostaglandins; D011980:Receptors, Progesterone; D015735:Mifepristone