Erythropoietin cell biology.
Erythropoietin (EPO) mediates its biologic actions in responsive cells through the 78 kDa cell surface form of the EPO receptor. The biosynthesis, activations, and destruction of EPO receptors are described. The binding of EPO to its receptor leads to the activation of a tyrosine protein kinase(s) that results in the phosphorylation of the receptor and other proteins.
Division of Hematology, Vanderbilt University School of Medicine, Nashville, Tennessee.
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Sawyer
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D000818:Animals; D004921:Erythropoietin / Q000378:metabolism*; D005622:Friend murine leukemia virus / Q000502:physiology; D006801:Humans; D017467:Receptors, Erythropoietin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship
D017467:Receptors, Erythropoietin; D004921:Erythropoietin