Carbidopa/levodopa and selegiline do not affect platelet mitochondrial function in early parkinsonism.
Previous studies have demonstrated impaired complex I activity in platelets from Parkinson's disease (PD) patients who were receiving levodopa and other medications for their disease. Eleven patients with early PD underwent three sequential plateletphereses: while on no medication, after receiving carbidopa/levodopa for 1 month, and after receiving carbidopa/levodopa plus selegiline for 1 additional month. As expected, carbidopa/levodopa and selegiline significantly improved motor function in these patients. Treatment with carbidopa/levodopa alone and carbidopa/levodopa plus selegiline did not affect the activities of complexes I, II/III, and IV and citrate synthetase. These observations support the hypothesis that impaired complex I activity in PD patients is a characteristic of the disease and not due to medications.
Department of Neurosciences, University of California, San Diego.
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Shults
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Nasirian
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Ward
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Nakano
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Pay
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Hill
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Haas
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D002230:Carbidopa / Q000627:therapeutic use*; D002950:Citrate (si)-Synthase / Q000097:blood; D004579:Electron Transport; D042963:Electron Transport Complex II; D014450:Electron Transport Complex III / Q000097:blood; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000097:blood; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000097:blood; D010088:Oxidoreductases / Q000097:blood; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy*; D010983:Plateletpheresis; D012642:Selegiline / Q000627:therapeutic use*; D013385:Succinate Dehydrogenase / Q000097:blood
D009097:Multienzyme Complexes; D012642:Selegiline; D007980:Levodopa; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; D016660:NAD(P)H Dehydrogenase (Quinone); D002950:Citrate (si)-Synthase; D014450:Electron Transport Complex III; D002230:Carbidopa