Effect of gugulipid on bioavailability of diltiazem and propranolol.
The effect of single oral dose of 1 gm gugulipid was studied on bioavailability of single oral dose of propranolol (40 mg) and diltiazem (60 mg) in 10 and 7 normal healthy male volunteers respectively. It was a randomised within group crossover study. Blood samples were collected at hourly intervals upto 8 hrs. Gugulipid significantly reduced (P < .01) peak plasma concentration (Cmax) and area under curve (AUC 0-8 hrs) of both the drugs in normal volunteers. Such interaction in patients receiving propanolol or diltiazem with gugulipid may lead to diminished efficacy or nonresponsiveness due to significant reduction in bioavailability.
Dept of Pharmacology, Seth GS Medical College, Parel, Bombay.
S S
SS
Dalvi
V K
VK
Nayak
S M
SM
Pohujani
N K
NK
Desai
N A
NA
Kshirsagar
K C
KC
Gupta
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D029744:Commiphora; D018592:Cross-Over Studies; D004110:Diltiazem / Q000493:pharmacokinetics*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D053149:Plant Gums; D011433:Propranolol / Q000493:pharmacokinetics*
D000960:Hypolipidemic Agents; D010936:Plant Extracts; D053149:Plant Gums; C018562:guggulu extract; D011433:Propranolol; D004110:Diltiazem