Comparison of topical ciprofloxacin to conventional antibiotic therapy in the treatment of experimental Pseudomonas aeruginosa keratitis.
We evaluated the efficacy of topical ciprofloxacin (3.0 mg/ml) in the treatment of experimental Pseudomonas aeruginosa keratitis in 60 rabbits. We compared ciprofloxacin treatment with double drug therapy consisting of tobramycin (13.6 mg/ml) plus polymyxin B (25,000 U/ml) or carbenicillin (6 mg/L). Two strains of P. aeruginosa were used. One was a strain well characterized for use in experimental Pseudomonas keratitis (ATCC organism 27853); the second was an organism from a patient with a Pseudomonas corneal ulcer. Rabbits were treated for 16 h, after which the corneas were excised, homogenized, and plated serially for residual colony-forming units. Both organisms responded significantly better to topical off-the-shelf ciprofloxacin than to therapy with two conventional antipseudomonal fortified antibiotic drugs (p < or = 0.0001).
Guzek
J P
JP
Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California 92357.
Chacko
D
D
Kettering
J D
JD
Wessels
I F
IF
Aprecio
R M
RM
D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003315:Cornea / Q000382:microbiology; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000254:growth & development; D011817:Rabbits; D011897:Random Allocation
D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin