Alpha tocopherol improves focal glomerulosclerosis in rats with adriamycin-induced progressive renal failure.
The effect of d-alpha-tocopherol on the progression of renal dysfunction was investigated in rats injected with adriamycin (ADR), a model of progressive glomerulosclerosis associated with the nephrotic syndrome. Treatment with d-alpha-tocopherol was started 1 day before or 1 day after ADR injections (BE-TOC or AF-TOC rats). When compared to rats without d-alpha-tocopherol treatment (ADR-CON rats), the serum total cholesterol and triglyceride levels were significantly lower in the BE-TOC and AF-TOC groups. In week 16, the LDL cholesterol level and the atherogenic index were both significantly lower in BE-TOC and AF-TOC rats than in ADR-CON rats. The urinary protein, serum creatinine, blood urea nitrogen, malondialdehyde, and systolic blood pressure levels as well as the glomerulosclerosis score were high in ADR-CON rats, and reduced in BE-TOC or AF-TOC rats. There were no significant differences in body weight and serum albumin between the three groups in week 16. It is concluded that d-alpha-tocopherol can improve hyperlipidemia and ameliorate glomerulosclerosis in rats with ADR-induced progressive renal failure. Thus, d-alpha-tocopherol may have the potential for clinical application to treat focal glomerulosclerosis.
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
M
M
Washio
F
F
Nanishi
S
S
Okuda
K
K
Onoyama
M
M
Fujishima
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D004317:Doxorubicin / Q000633:toxicity*; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D007668:Kidney / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew; D051437:Renal Insufficiency / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D004317:Doxorubicin