[Changes in the immune status in patients with basal cell carcinoma of the eyelids of various TNM stages].
Various lymphocyte populations/subpopulations--Leu-4+ (CD3+), Leu-2+ (CD8+), CD4+/CD8+ ratio, Leu-14+ (CD22+), Leu-M5+ and HLA-DR+--were studied in 104 patients with basal cell carcinoma (BCC) of the eyelid in different TNM stages by Coulter EPICS flow cytometry preoperatively. For comparison, an age-matched control group of 60 clinically healthy individuals (30 male and 30 female) was used. The mean percentage of CD4+ T-lymphocytes was significantly decreased in T3N0M0 and T4N0M0 stages. In all TNM stages, especially in T3N0M0 and T4N0M0, the CD8+ T-lymphocyte subpopulation was significantly larger than in the control group. In all TNM stages the CD4+/CD8+ ratio was significantly lower than that of the control group. The degree of immune imbalance correlated directly with tumor size. The immunosuppression may be one factor in the development of BCC of the eyelid. Age- or genetic-related depression of cell-mediated immunity and increased exposure to carcinogenic agents, especially UV light, may play a part.
Sivkova
N
N
Universitäts-Augenklinik, Medizinische Universität Plovdiv.
Grigorov
L
L
Kreissig
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016516:CD4-CD8 Ratio; D002280:Basal Cell Carcinoma / Q000276:immunology* / Q000473:pathology; D005142:Eyelid Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016176:T-Lymphocyte Subsets / Q000276:immunology*
Veränderungen des Immunstatus bei Patienten mit Basalzellkarzinom der Lider in verschiedenen TNM-Stadien.