Evolution of immunological abnormalities in HIV infection by vertical transmission.
Forty-four children infected through vertical transmission, from a total of 146 born to HIV-positive mothers, were studied. Immunological data were analysed and compared with those of the noninfected children. Two transmission patterns emerge from the clinical and immunological characteristics: (i) infants infected during pregnancy with severe immunodeficiency and clinical manifestations before the age of 1 year, and (ii) children probably infected perinatally, who have better clinical outcome. Immunological data are important for prognosis and early therapeutic protocols to be established.
Immunology Unit, C.S. Valle Hebrón, Barcelona, Spain.
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Español
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Caragol
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JM
Bertran
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology; D006679:HIV Seropositivity / Q000276:immunology* / Q000635:transmission; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D007375:Interleukin-1 / Q000097:blood / Q000276:immunology; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology; D009035:Mothers; D011379:Prognosis; D012720:Severity of Illness Index
D015483:HIV Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1; D007376:Interleukin-2; D007371:Interferon-gamma