Immunogenicity of rabies vaccines used during an urban epizootic of rabies in Mexico.
From 1 July 1987 to 31 December 1988, 30% of 247 rabid dogs in Hermosillo, Mexico had a positive history of rabies vaccination. Serosurveys suggested that inactivated suckling mouse brain vaccine (INACT-SMBV) and inactivated tissue culture vaccine (INACT-TC) used before and during the epizootic were poor immunogens. Prospective studies showed that only about one-third of dogs vaccinated with INACT-SMBV were seropositive 5 weeks after vaccination. Lack of vaccine potency was the most likely cause of poor immunogenicity. Rabies vaccines should be evaluated periodically by measuring antibody responses in animals. In some circumstances, minimum seroconversion rates and antibody titres in vaccinated animals may be better measures of immunogenicity than relative potency.
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
T R
TR
Eng
D B
DB
Fishbein
H E
HE
Talamante
M
M
Fekadu
G F
GF
Chavez
F J
FJ
Muro
G M
GM
Baer
D000818:Animals; D004196:Disease Outbreaks / Q000662:veterinary; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D011446:Prospective Studies; D011818:Rabies / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*
D011819:Rabies Vaccines