Sodium lactate response and familial risk for panic disorder.
OBJECTIVE
The authors used the family study method to test the hypothesis that sodium lactate response defines two subtypes of panic disorder.


METHODS
Rates of panic disorder in 142 first-degree relatives of patients who responded to sodium lactate, 88 first-degree relatives of patients who did not respond to sodium lactate, and 231 first-degree relatives of never mentally ill subjects were compared.


RESULTS
No difference in familial transmission of panic disorder was found between the two patient groups.


CONCLUSIONS
The findings do not support the notion that panic disorder subtypes are associated with lactate sensitivity.
Department of Therapeutics, New York State Psychiatric Institute, New York.
A H
AH
Reschke
S
S
Mannuzza
T F
TF
Chapman
J D
JD
Lipsitz
M R
MR
Liebowitz
J M
JM
Gorman
D F
DF
Klein
A J
AJ
Fyer
D015415:Biomarkers; D005190:Family; D005260:Female; D006801:Humans; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D016584:Panic Disorder / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors
D015415:Biomarkers; D007773:Lactates; D019344:Lactic Acid