Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach progressing to overt B cell malignancy.
A 70 year old man, who underwent subtotal gastrectomy under the diagnosis of reactive lymphoid hyperplasia 6 years earlier, suffered from diffuse large-cell-type B cell lymphoma in the remnant stomach. Retrospectively reviewed, the initial lesion was consistent with mucosa-associated lymphoid tissue (MALT) lymphoma, a low-grade B cell malignancy, based upon histologic, cytologic and immunohistochemical features. Both the initial and recurrent tumors revealed the phenotypes of mantle zone cells, DBA44-positive. It is noteworthy that the overt lymphoma cells retained the capacity for inducing germinal center-like nodules consisting of LN1 and DNA7-positive cells even in the invading site. The diagnosis of reactive lymphoid hyperplasia of the stomach should be made after careful exclusion of the possibility of MALT lymphoma.
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
S
S
Umemura
X
X
Tang
H
H
Aihara
Y
Y
Tsutsumi
D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology*