Pharmacokinetics and dosage regimen of cefotaxime in cross-bred calves following single intramuscular administration.
The pharmacokinetics, penetration into erythrocytes and plasma protein binding of cefotaxime were investigated in cross-bred calves. Following a single intramuscular dose of cefotaxime (10 mg/kg), the absorption half-life and elimination half-life were 0.13 +/- 0.03 h and 2.97 +/- 0.72 h, respectively. The apparent volume of distribution and total body clearance were 3.28 +/- 0.72 L/kg and 0.78 +/- 0.08 L/kg per h, respectively. The extent of penetration into erythrocytes was 24-40% of the total blood concentration. Cefotaxime was bound to plasma proteins of calves to the extent of 25.5-33.6%. A satisfactory intramuscular dosage regimen for cefotaxime in calves would be 11 mg/kg followed by 10 mg/kg at 7 h intervals.
Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
S K
SK
Sharma
A K
AK
Srivastava
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002417:Cattle / Q000378:metabolism*; D002439:Cefotaxime / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule / Q000662:veterinary; D004912:Erythrocytes / Q000378:metabolism; D066298:In Vitro Techniques; D007273:Injections, Intramuscular / Q000662:veterinary*; D008297:Male; D011485:Protein Binding
D001798:Blood Proteins; D002439:Cefotaxime