Epidemiology of tetracycline-resistance determinants.
Resistance to tetracycline is generally due either to energy-dependent efflux of tetracycline or to protection of the bacterial ribosomes from the action of tetracycline. The genes that encode this resistance are normally acquired via transferable plasmids and/or transposons. Tet determinants have been found in a wide range of Gram-positive and Gram-negative bacteria and have reduced the effectiveness of therapy with tetracycline.
Dept of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
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Roberts
D004251:DNA Transposable Elements; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000378:metabolism; D010957:Plasmids; D012270:Ribosomes / Q000187:drug effects; D013752:Tetracycline / Q000493:pharmacokinetics / Q000494:pharmacology*; D013753:Tetracycline Resistance / Q000235:genetics* / Q000502:physiology
D004251:DNA Transposable Elements; D013752:Tetracycline