[Renal effects of prolonged indomethacin therapy in premature infants].
BACKGROUND
Indomethacin therapy for large patent ductus arterious would be more effective when it is prescribed for 5 or 6 days vs 2 or 3 days. Effects on renal function of such prolonged therapy is still debated.


METHODS
Seven preterm infants (gestational age: 28.6 +/- 0.9 weeks; birth-weight: 1,169 +/- 267 g) with symptomatic patent ductus arterious were given indomethacin, 0.1 mg/kg/day for 6 days (four patients) and 5 days (three patients). Urinary water excretion, water output/input ratio, creatinine clearance and body weight were measured before and every day during therapy.


RESULTS
Urinary water excretion, water output/input ratio and creatinine clearance were significantly decreased after 5 days of treatment, -40 +/- 30%, -42 +/- 27% and -48 +/- 31%, respectively. Creatinemia and body weight were significantly increased, + 34 +/- 36% and + 9 +/- 7%, respectively. Mean sodium plasma level and fractional excretion of sodium, potassium and chloride remained stable.


CONCLUSIONS
Prolonged therapy with indomethacin does not avoid the renal side effects seen with shorter administration.
Service de pédiatrie 2, hôpital d'Enfants, Dijon, France.
J B
JB
Gouyon
M
M
Chouchane
M
M
Françoise
D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology
D007213:Indomethacin
Effets rénaux d'un traitement prolongé par indométacine chez le prématuré.