[Absolute and relative bioavailability of germanium in the rabbit].
The debated consumption of germanium suggested the authors to compare biopharmaceutical parameters of germanium oxide and germanium sesquioxide. A first evaluation, in rabbit, has been based on Germanium blood levels determined by atomic absorption spectrometry, after cross administration of both products by the I.V. and oral routes. When given orally, the apparent oxide bioavailability is very low (about 10%) but better than that of the sesquioxide. That difference could result from differences of disposition parameters of both products, which have to be studied late.
Laboratoire de Toxicologie, Faculté des Sciences Pharmaceutiques et Biologiques, Rennes.
F S
FS
Anger
J P
JP
Anger
P A
PA
Sado
F
F
Chevanne
D000818:Animals; D016587:Antimutagenic Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D005857:Germanium / Q000493:pharmacokinetics*; D008297:Male; D011817:Rabbits
D016587:Antimutagenic Agents; D005857:Germanium; C040516:germanium oxide
Biodisponibilités absolue et relative du germanium chez le lapin.