[New achievements in the fluoroquinolone problem: possibilities of increasing activity and expansion of the spectrum of action].
Studies of antibacterial compounds and drugs belonging to the derivatives of 6-fluoroquinolones are reviewed. The structure-function dependencies, the introduction of additional fluorine atoms to the structure and the cycle substitutions at positions 5 and 8 are discussed from the viewpoint of the antibacterial activity increasing and the spectrum broadening. The data on the activity of new 6-fluoroquinolones against gram positive bacteria, including pneumococci, anaerobic organisms, mycobacteria, chlamydia, and mycoplasma are presented. Compounds belonging to 6-fluoroquinolones substituted at positions 2 and 3 are discussed. The activity of 6-fluoroquinolones and their nonfluorinated derivatives is compared in general.
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Padeĭskaia
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D024841:Fluoroquinolones
Novoe v probleme ftorkhinolonov: vozmozhnosti povysheniia aktivnosti i rasshireniia spektra deĭstviia.