[Incidence of adverse reactions to additives. Our experience over 10 years].
No published information exists about the incidence of food additives reactions in the general population. Most studies have been made in patients with urticaria and bronchial asthma. The majority of them lack an adequate design and, therefore, the reported results should be interpreted with extreme caution. In this article, we expose our ten years experience in this field. We have added up 1941 oral provocation tests, with an ample battery of additives, administering the tested substances directly or in aqueous or acid solution (1110 in patients with urticaria, mainly chronic urticaria, and 831 in asthmatic subjects, with or without aspirin intolerance). From these exhaustive data, we get the following conclusions: 1) in contrast with other-investigators, and using similar or even higher provocation doses, we get a very low incidence of adverse reactions. 2) We are sceptical that food additives play any role in chronic urticaria or in other cutaneous processes (only 0.63% provocation tests resulted in an urticarial exacerbation, and none of them was repeated after re-provocation). 3) In asthmatic patients, similar results were obtained, except with sulfites in acid solution challenge test (10% asthmatic exacerbations), possibly as a sign of nonspecific bronchial hyperreactivity. 4) The prescription of food additives free restrictive diets does not seem to be justified. The should be followed only by those patients with clear evidence of additives reactions. 5) In most cases, with punctual exceptions, the study of food additives reactions, in clinical allergy, implies a waste of time.
Sección de Alergología, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia.
J
J
Hernández García
J
J
García Sellés
J M
JM
Negro Alvarez
J A
JA
Pagán Alemán
J D
JD
López Sánchez
D000328:Adult; D000368:Aged; D001249:Asthma / Q000139:chemically induced; D001986:Bronchial Spasm / Q000139:chemically induced / Q000453:epidemiology; D002908:Chronic Disease; D003875:Drug Eruptions / Q000453:epidemiology / Q000209:etiology; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005503:Food Additives / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000209:etiology / Q000276:immunology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014581:Urticaria / Q000139:chemically induced
D005503:Food Additives
Incidencias de reacciones adversas con aditivos. Nuestra experiencia de 10 años.