Allopurinol dose is important for attenuation of liver dysfunction after normothermic ischemia: correlation between bile flow and liver enzymes in circulation.
We have investigated the effect of two doses of allopurinol (ALL) (100 and 50 mg/kg) administered i.v. on liver function after 1 h of normothermic ischemia. ALL given in a concentration of 100 mg/kg significantly improved bile output after 1 and 24 h of reperfusion. Hepatocyte injury reflected by alanine aminotransferase (ALT) and lactic dehydrogenase (LDH) in plasma was also significantly reduced at 24 h, but not at 1 h of reperfusion compared with controls. ALL administered at a concentration of 50 mg/kg had some protective effect. Significant correlation between circulating liver enzymes and bile output at 24 h after reperfusion indicates an important pathophysiologic link between hepatocyte function and injury in this time window.
Karwinski
W
W
Department of Surgery, University of Bergen, Norway.
Garcia
R
R
Helton
W S
WS
D000410:Alanine Transaminase / Q000097:blood*; D000493:Allopurinol / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D001646:Bile / Q000378:metabolism*; D001831:Body Temperature; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*
D000493:Allopurinol; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase