[The metabolic syndrome. Pathophysiologic causes, diagnosis, therapy].
The individual components of the metabolic syndrome such as central obesity, dyslipidemia with increased triglycerides and decreased HDL-cholesterol, hyperuricemia, hypertension and progressive glucose intolerance are markers for an increased risk of atheroma and type 2 (non-insulin-dependent) diabetes. All components, with the exception of hyperuricemia, are associated with skeletal muscle insulin resistance, leading to compensatory chronic hyperinsulinemia. Insulin resistance/hyperinsulinemia, in turn, is associated with a series of hypertensiogenic and atherogenic side effects, aggravating the individual components of the metabolic syndrome. From a more pathophysiologically orientated point of view, early identification of individuals obviously at risk for atheroma and type 2 diabetes, as well as early intervention aimed at the improvement of reduced insulin action may play a central role in an integrated life-style approach of primary prevention of atherosclerosis and type 2 diabetes.
Medizinische Abteilung, Institut für Diabetesforschung am Krankenhaus München-Schwabing, Bundesrepublik Deutschland.
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Standl
D001161:Arteriosclerosis / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D006946:Hyperinsulinism / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D018482:Muscle, Skeletal / Q000503:physiopathology; D009765:Obesity; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D008055:Lipids; D014527:Uric Acid
Das metabolische Syndrom. Pathophysiologische Ursachen, Diagnostik, Therapie.