[Chronic gastritis and prostaglandins. Results of endoscopic screening].
An endoscopic screening was carried out during the period between July 1989 and December 1991 in the Municipality of Roccagorga (LT) in order to: a) evaluate the presence of various forms of gastritis and pre-cancerous lesions; 2) verify the effect of the administration of prostaglandins (Misoprostol) on the evolution of superficial chronic gastritis (CG). A total of 468 endoscopy were performed (17% of the population aged between 20 and 75 years old). 22% of the subjects examined were found to be endoscopically normal; 34% presented symptoms of mild esophagitis and 4% of moderate esophagitis. The prevalence of duodenal ulcer was 10.6% and gastric ulcer 3.4%. Gastric carcinoma was diagnosed in 6 patients (1.2%). 8.5% of patients were found to have atrophic CG and 15.3% superficial CG. Thirty-six patients with superficial CG were randomly divided into two groups: A) treated with Misoprostol 600 mg/day for 6 months; B) controls (placebo). The administration of Misoprostol did not influence the evolution of CG, whereas it caused a reduction in the incidence of type 1 intestinal metaplasia. Misoprostol also led to an improvement in dyspeptic symptoms. The results of the present study do not suggest a role of prostaglandins in the natural evolution of CG.
Spaziani
E
E
Cattedra di Patologia Chirurgica VII, Università degli Studi di Roma La Sapienza.
Genco
A
A
Neri
T
T
Surgo
D
D
Scucchi
L
L
Di Stefano
D
D
Guarino
E
E
Tretola
V
V
Di Gennaro
G
G
Silecchia
G
G
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004381:Duodenal Ulcer / Q000175:diagnosis; D005260:Female; D005756:Gastritis / Q000175:diagnosis* / Q000188:drug therapy*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016595:Misoprostol / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000175:diagnosis; D013276:Stomach Ulcer / Q000175:diagnosis
D016595:Misoprostol
Gastriti croniche e prostaglandine. Risultati di uno screening endoscopico.