Temporal lobe abnormalities in multigenerational families with schizophrenia.
Brain structure in familial schizophrenia was studied with computerized tomography in 42 individuals from six multigenerational families. Sulcal enlargement in the lateral temporal cortex, and ventricular and cisternal enlargement in the medial temporal region were observed in psychotic individuals compared to unaffected family members. Genetic factors in familial schizophrenia may exert part of their effect through determining or altering temporal lobe structure.
Honer
W G
WG
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Bassett
A S
AS
Smith
G N
GN
Lapointe
J S
JS
Falkai
P
P
D000328:Adult; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000235:genetics*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed