[Beta-lactam antibiotics (ampicillin, cefotaxime) in prevention of experimental plague in albino mice, caused by non-fractioned strains of the pathogen].
The prophylactic action of betalactam antibiotics such as ampicillin and cefotaxime in plague was studied on albino mice infected subcutaneously by Fra+ (Y. pestis 231) and Fra- (Y. pestis 231 Fra-, K-16) variants of the plague microbe. Ampicillin, a semisynthetic penicillin, was prophylactically less active in experimental plague infection induced by the fraction I defect forms of Y. pestis. Cefotaxime, a 3rd generation cephalosporin, was active in experimental plague induced by both the type and the fraction-free strains of Y. pestis.
Samokhodkina
E D
ED
Ryzhko
I V
IV
Tsuraeva
R I
RI
Pasiukov
V V
VV
D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D002439:Cefotaxime / Q000494:pharmacology*; D002458:Cell Fractionation; D014644:Genetic Variation; D051379:Mice; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D010930:Plague / Q000382:microbiology / Q000517:prevention & control*; D015010:Yersinia pestis / Q000235:genetics*
D000667:Ampicillin; D002439:Cefotaxime
Betalaktamnye antibiotiki (ampitsillin, tsefotaksim) v profilaktike éksperimental'noĭ chumy belykh mysheĭ, vyzvannoĭ besfraktsionnymi shtammami vozbuditelia.