Baclofen poisoning in children.
Six cases of acute baclofen (LIORESAL) overdose in children are reported. Rapid onset of central nervous system depression with respiratory depression was present to a greater or lesser degree in all patients. Agitation, convulsions and ataxia were also seen. The entire cohort responded to supportive management. An accurate assessment of the quantity of drug ingested was not possible. The need for education on safe drug storage and disposal is emphasized.
Cooke
D E
DE
Department of Paediatrics and Child Health, University of Cape Town, Rondebosch, South Africa.
Glasstone
M A
MA
D001259:Ataxia / Q000139:chemically induced; D001418:Baclofen / Q000506:poisoning*; D002490:Central Nervous System / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012137:Respiratory System / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced; D013019:South Africa
D001418:Baclofen