TGF-beta-receptor-mediated signaling.
Transforming growth factor beta (TGF-beta) and its many relatives are thought to play key roles in the control of cell proliferation and differentiation. In particular, the ability of TGF-beta to induce growth arrest in epithelial cells has drawn considerable attention. The recent cloning of TGF-beta receptors, which are considered to be prototypes of a new class of cell-surface receptors, has provided a first insight into how TGF-beta signaling induces a variety of intracellular changes. Furthermore, recent advances in the characterization of the cell-cycle machinery have stimulated studies aimed at understanding how TGF-beta signaling leads to growth arrest in the late G1 phase of the cell cycle.
Derynck
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Department of Growth and Development, University of California at San Francisco 94143-0640.
D000595:Amino Acid Sequence; D002453:Cell Cycle / Q000502:physiology; D016213:Cyclins / Q000494:pharmacology; D008969:Molecular Sequence Data; D047428:Protein Kinase Inhibitors; D018125:Receptors, Transforming Growth Factor beta / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000494:pharmacology
D016213:Cyclins; D047428:Protein Kinase Inhibitors; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta