A miconazole lacquer in the treatment of Candida-associated denture stomatitis.
An open randomized controlled study involving two parallel treatment groups comprising 50 patients with Candida-associated denture stomatitis was performed to evaluate the efficacy and safety of one application of 1 g of miconazole 55 mg/g denture lacquer in comparison with that of a commercially available miconazole 2% gel applied four times daily for 2 weeks. The results showed a pronounced reduction in the yeast scores and a reduction in the palatal erythema in both treatment groups, but there was no apparent difference between the efficacy of the two treatments. The results indicate that a single application of the denture lacquer (55 mg of miconazole) is safe and almost as effective as administration of gel four times a day for 2 weeks (3000 mg of miconazole).
Department of Gerodontology and Removable Prosthodontics, Université de Genève, Switzerland.
E
E
Budtz-Jörgensen
P
P
Carlino
D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D004334:Drug Administration Schedule; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage*; D013282:Stomatitis, Denture / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome
D008825:Miconazole