[Quantitative computed tomographic determination of spleen size to assess the course of malignant lymphomas].
The purpose of this study was to correlate CT-assessed spleen indices (length x width x depth) and their changes under therapy or in the follow-up, with the clinical course and morphological changes. In 66 patients with 200 CT's of the abdomen the spleen index was calculated and 134 spleen index differences (delta SI) were correlated with the clinical outcome. The normal group showed a mean of delta SI of -8 = 112, equivalent boundaries of -120 and 104. delta SI of progressive lymphomas (n = 32) was 313 (p < 0.01). In 10/14 patients of this group, morphological signs of infiltration were found. In regressive lymphomas (n = 63) we found delta SI = -211 (p < 0.001). 23/29 with delta SI < -120 showed signs of spleen involvement in the preliminary examination. Since there are only slight intraindividual changes of CT-assessed spleen indices and a good correlation of spleen index differences with the clinical outcome. the spleen index is a useful instrument in the follow-up of malignant lymphomas.
Insitut für Röntgendiagnostik, Universität Würzburg.
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Trusen
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Tschammler
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Wittenberg
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Krahe
D018450:Disease Progression; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012008:Recurrence; D012074:Remission Induction; D013154:Spleen / Q000000981:diagnostic imaging*; D013163:Splenomegaly / Q000000981:diagnostic imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000295:instrumentation
Quantitative computertomographische Milzgrössenbestimmung zur Verlaufsbeurteilung bei malignen Lymphomen.