Assignment of Tp53 and Tk1 to chromosome 13 in Peromyscus by fluorescence in situ hybridization.
Mus domesticus DNA probes for the tumor suppressor protein-53 (Tp53) and thymidine kinase-1 (Tk1) genetic loci were used to identify clones representing these loci in a Peromyscus leucopus (white-footed mouse) cosmid library. The cosmid-derived homologous probes were biotinylated and hybridized to P. maniculatus (deer mouse) chromosomes. Probes for both genes hybridized to the chromosome 13 pair identified by prior G-banding. Deer mouse chromosome 13 shares a region of homology with mouse chromosome 11, rat chromosome 10 and human chromosome 17.
Department of Biological Sciences, University of South Carolina, Columbia.
Z
Z
Wang
S R
SR
Young
L
L
Liu
W D
WD
Dawson
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D003360:Cosmids; D015723:Gene Library; D016158:Genes, p53; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D010542:Peromyscus / Q000235:genetics*; D051381:Rats; D013937:Thymidine Kinase / Q000235:genetics*
D013937:Thymidine Kinase