Intracellular and extracellular penetration of azithromycin into inflammatory and noninflammatory blister fluid.
The penetration of azithromycin into the blister fluids of six volunteers was analyzed after a 5-day regimen (total of 1.5 g). Differences in drug concentrations in a paper disk and serum and in the mass of azithromycin from inflammatory blister chamber leukocytes and noninflammatory blister chamber leukocytes were significant (P < 0.05).
Department of Pharmacy, Hartford Hospital, Connecticut 06115.
C D
CD
Freeman
C H
CH
Nightingale
D P
DP
Nicolau
P P
PP
Belliveau
M A
MA
Banevicius
R
R
Quintiliani
D017963:Azithromycin / Q000493:pharmacokinetics*; D001768:Blister / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male
D017963:Azithromycin