Hair and urine analysis: relative distribution of drugs and their metabolites.
This work studies the distribution of cocaine and heroin metabolites in hair and urine of living polidrug abusers. Cocaine, benzoylecgonine (BEG), ecgonine methyl ester (EME), morphine, codeine and 6-monoacetylmorphine (6-MAM) were simultaneously extracted and analyzed by GC/MS in SIM mode. The results obtained show a different distribution of heroin and cocaine metabolites in urine and hair. In urine, we generally find BEG and EME for cocaine abuse, and morphine for heroin abuse. In hair, we detect cocaine and MAM as major metabolites for cocaine and heroin abuse, respectively.
Department of Legal Medicine, University of Santiago de Compostela, Spain.
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Bermejo Barrera
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Strano Rossi
D003042:Cocaine / Q000031:analogs & derivatives / Q000032:analysis* / Q000652:urine; D003061:Codeine / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D003932:Heroin / Q000032:analysis* / Q000652:urine; D006801:Humans; D009020:Morphine / Q000032:analysis; D009022:Morphine Derivatives / Q000032:analysis; D009294:Narcotics / Q000032:analysis; D019966:Substance-Related Disorders / Q000378:metabolism
D009022:Morphine Derivatives; D009294:Narcotics; C005618:benzoylecgonine; D003932:Heroin; D009020:Morphine; D003042:Cocaine; C026979:6-O-monoacetylmorphine; D003061:Codeine; C034524:ecgonine methyl ester