Effects of adrenergic receptor blockers on adrenaline and nicotine-induced hyperglycaemia in the rat.
Studies in fasted, anaesthetized rats have shown that adrenaline and nicotine-induced hyperglycaemia is mediated via activation of beta-adrenoceptors. The hyperglycaemic response to nicotine is different from that of adrenaline in that, unlike adrenaline hyperglycaemia, nicotine hyperglycaemia is characterized by a long latent period, delayed attainment of peak of response and sustained hyperglycaemia throughout the 120 minutes post-injection observation. Comparison with previous studies in dogs showed that different receptors are involved in nicotine hyperglycaemia in fasted dogs and fasted rats.
Department of Physiology, College of Medicine, University of Ibadan, Nigeria.
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Oyebola
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Alada
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004195:Disease Models, Animal; D004285:Dogs; D004837:Epinephrine; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009538:Nicotine; D011217:Practolol / Q000627:therapeutic use*; D011224:Prazosin / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001786:Blood Glucose; D009538:Nicotine; D011433:Propranolol; D011217:Practolol; D011224:Prazosin; D004837:Epinephrine