Chromophore-enhanced laser-tumor tissue photothermal interaction using an 808-nm diode laser.
A diode laser was used to irradiate tumor tissue, with indocyanine green as the chromophore. The 808-nm wavelength radiation falls within the absorption peak of the chromophore (about 780 nm). The preliminary results in this report revealed clear and significant coupling of this laser and indocyanine green in laser-tissue photothermal interaction. The chromophore targeted tissue showed laser damage while peripheral tissues remained intact. Without the chromophore, this laser inflicted no apparent tissue damage in the non-contact mode with irradiance up to 1755 J/cm2.
Chen
W R
WR
Oklahoma School of Science and Mathematics, Oklahoma City 73104.
Adams
R L
RL
Heaton
S
S
Dickey
D T
DT
Bartels
K E
KE
Nordquist
R E
RE
D000818:Animals; D005260:Female; D006358:Hot Temperature; D066298:In Vitro Techniques; D007208:Indocyanine Green; D007834:Lasers; D008325:Mammary Neoplasms, Experimental / Q000628:therapy*; D017319:Photosensitizing Agents; D051381:Rats; D011920:Rats, Inbred WF
D017319:Photosensitizing Agents; D007208:Indocyanine Green