[Cetyltrimethylammonium naproxenate as vaginal lavage in the therapy of vulvovaginal dystrophies in the postmenopause].
A peculiar aspect of the postmenopausal period is atrophy of the lower genital tract, vagina and vulva. This is due to estrogen deficiency and is accompanied by vaginal pH elevation, lower number of lactobacilli and increased incidence of aspecific vulvovaginitis. We tested a new vaginal douche with an antibacterial-anti-inflammatory (non antibiotic-nonsteroidal) principle, cetyltrimethylammonium naproxenate 0.223% as an adjunct to classical estrogen topical replacement therapy. We treated 34 menopausal patients (mean age 67 yrs) in a double parallel controlled (15 A only estrogen topical therapy vs 19 B topical estrogen plus cetyltrimethylammonium naproxenate douches uid) study for 30 days. A significant reduction of symptoms was obtained in both groups although a faster reduction has been seen in the group treated with both drugs (= B). In conclusion a better replacement of physiological pH with reappearance of lactobacilli, a selective action on vaginal pathogens, a faster symptom remission and an higher psychophysical welfare can be attributed to the vaginal douche used in adjunct to classical estrogen topical therapy.
Scuola di Specializzazione in Ginecologia ed Ostetricia, Università Cattolica Sacro Cuore, Roma.
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Plotti
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Giulianelli
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Buttini
D000368:Aged; D002593:Cetrimonium Compounds / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D045166:Estradiol Congeners / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009824:Ointments; D017698:Postmenopause; D007507:Therapeutic Irrigation / Q000379:methods; D013997:Time Factors; D014621:Vagina; D014623:Vaginal Diseases / Q000188:drug therapy*; D014845:Vulvar Diseases / Q000188:drug therapy*
D002593:Cetrimonium Compounds; D045166:Estradiol Congeners; D009824:Ointments
Il naprossenato di cetiltrimetilammonio lavanda vaginale nella terapia delle distrofie vulvo-vaginali in post-menopausa.