Pharmacokinetics of intravenous omeprazole in children.
This study was undertaken to define the pharmacokinetics of omeprazole in children and included 13 patients, heterogeneous in terms of age (0.3 to 19 years), underlying disease and biological constants, indication of omeprazole administration and associated therapy. The dose administered ranged from 36.9 to 139 mg.1.73 m-2. The pharmacokinetic parameters of omeprazole were: systemic clearance, 0.23 l.kg-1.h-1; volume of distribution, 0.45 l.kg-1; elimination half life 0.86 h; but were highly variable between individuals. Dosage, differences in hepatic and renal function and associated therapy may contribute to inter-individual variability. Within the range of doses administered, the pharmacokinetic parameters were similar to those reported in adults. The drug has been well tolerated in all children.
Department of Clinical Pharmacology, Hôpital Robert Debré, Paris, France.
E
E
Jacqz-Aigrain
M
M
Bellaich
C
C
Faure
J
J
Andre
P
P
Rohrlich
V
V
Baudouin
J
J
Navarro
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D004941:Esophagitis / Q000188:drug therapy / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D009853:Omeprazole / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
D009853:Omeprazole