Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.
The aim of this study was to evaluate the efficiency of oral treatment with sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) on reducing mercury deposits in rat kidney after chronic exposure to inorganic mercury. The effect on kidney copper levels was also evaluated. The results showed that after two months of exposure to 50 ppm of mercury (as mercuric chloride) the concentration of mercury in the kidney was 124 micrograms/g wet tissue. At the same time copper concentration rose from 11 to 77 micrograms/g. DMPS treatment caused 2- and almost 4-fold reduction of mercury and copper, respectively. This study demonstrates that chronic exposure to inorganic mercury may alter metabolism of copper and that DMPS is an effective means for reduction of both mercury and copper.
Blanusa
M
M
Institute for Medical Research and Occupational Health, University of Zagreb, Croatia.
Prester
L
L
Radić
S
S
Kargacin
B
B
D000818:Animals; D003300:Copper / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D007669:Kidney Calculi / Q000188:drug therapy / Q000378:metabolism; D008628:Mercury / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution / Q000187:drug effects; D014494:Unithiol / Q000494:pharmacology*
D014494:Unithiol; D003300:Copper; D008628:Mercury