Thermoregulation and hypothalamic histamine turnover modulated by interleukin-1 beta in rats.
To clarify the involvement of hypothalamic histamine in thermogenic response provoked by high ambient temperature, or interleukin-1 beta (IL-1 beta), changes in rectal temperature and histamine turnover were investigated. Rectal temperature was maintained normally after exposure to high ambient temperature, but elevated by IL-1 beta. In spite of these different responses of body temperature, hypothalamic histamine turnover was increased in each treatment. The results suggest that hypothalamic histaminergic neurons are activated not only peripherally by high ambient temperature, but also centrally by IL-1 beta as endogenous pyrogen.
Department of Internal Medicine I, School of Medicine, Oita Medical University, Japan.
M
M
Kang
H
H
Yoshimatsu
R
R
Ogawa
M
M
Kurokawa
A
A
Oohara
Y
Y
Tamari
T
T
Sakata
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D006632:Histamine / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D007375:Interleukin-1; D006632:Histamine