Changes in the virulence of Mycobacterium bovis (BCG Phipps) in carbon tetrachloride treated mice.
Mild grade of liver damage was produced in mice by repeated subcutaneous injection of carbon tetrachloride. These mice along with saline treated mice were challenged with an avirulent vaccine strain of BCG (Phipps), intravenously. The CCl4 treated, BCG challenged mice developed disease and died much earlier than the controls, indicating an increased susceptibility to the avirulent strain in mice with mild hepatitis.
Division of Microbiology, Central Drug Research Institute, Lucknow.
H P
HP
Gupta
A
A
Srivastava
N B
NB
Singh
D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000382:microbiology*; D005260:Female; D008297:Male; D051379:Mice; D009163:Mycobacterium bovis / Q000187:drug effects* / Q000472:pathogenicity*; D014774:Virulence
D002251:Carbon Tetrachloride