The effect of N-acetylcysteine on the UVB-induced inhibition of epidermal DNA synthesis in rat skin.
The effect of N-acetylcysteine (NAC), on the UVB-induced inhibition of epidermal DNA synthesis in rat skin was investigated. Topical application of NAC, 30 min prior to UVB irradiation (20 kJ m-2), significantly reduced the UVB-induced inhibition of the epidermal (methyl-1',2'-3H)-thymidine uptake. These results indicate that NAC affords protection against at least some of the damaging effects of UVB radiation on epidermal DNA, probably by neutralization of UVB induced reactive species.
van den Broeke
L T
LT
Department of Medicinal Photochemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, Netherlands.
Beijersbergen
G M
GM
van Henegouwen
B
B
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects / Q000528:radiation effects*; D004261:DNA Replication / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
D004247:DNA; D000111:Acetylcysteine