31P magnetic resonance spectroscopy of the liver: correlation with standardized serum, clinical, and histological changes in diffuse liver disease.
The goal of this study was to analyze the possibilities of 31P MR spectroscopy to detect abnormal hepatic histological changes in patients with diffuse liver disease. 31P MR spectroscopy was performed, on a 1.5 T whole-body spectrometer using an image guided localization technique (ISIS), on 38 patients with various diffuse liver diseases, who all underwent histological and serum analysis, and 22 healthy volunteers. Phosphomonoester expressed as a fraction of total phosphorus (PME/P) showed a correlation with abnormal serum aspartate transaminase (AST), histological intralobular degeneration/focal necrosis, portal inflammation, and piecemeal necrosis. We found a lower correlation for PME/P with fibrosis. It was not possible to differentiate between fibrosis and cirrhosis. In summary, 31P MR spectroscopy is a technique to detect intralobular degeneration, inflammation and necrosis and to a less extent fibrosis. No diagnostic value was found with respect to steatosis and cholangitis. Furthermore, 31P MR spectroscopy is a poor method for classifying patients into diagnostic categories.
Department of Radiodiagnosis, University Hospital Utrecht, The Netherlands.
H N
HN
van Wassenaer-van Hall
J
J
van der Grond
J
J
van Hattum
C
C
Kooijman
T U
TU
Hoogenraad
W P
WP
Mali
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D016022:Case-Control Studies; D005355:Fibrosis; D006801:Humans; D008099:Liver / Q000737:chemistry; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis*; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009336:Necrosis; D010755:Organophosphates / Q000032:analysis; D010759:Phosphorus Isotopes
D010755:Organophosphates; D010759:Phosphorus Isotopes; D001219:Aspartate Aminotransferases