Evaluation of traditional African medicine "Compound R" for the treatment of thermal burn wounds in fuzzy rats.
The efficacy of an oil-in-water emulsion of a traditional Kenyan medicine, Compound R, on thermal burn wounds in fuzzy rats is reported. The burn wounds were inflicted on the depilated skin of rats with a 2 cm diameter aluminum template heated at 65 degrees C. Mean +/- SD days to healing (complete closure) were 9.9 +/- 2.2 (range 7 to 14 days) and 13.3 +/- 2.4 (range 10 to 16 days) for the treated and control (untreated) wounds, respectively (paired Student's t test, t value -5.667, p = 0.0003). Preliminary microbiologic results showed no activity of Compound R against some of the commonly encountered pathogens in burn wounds. Compound R appears to decrease the days to burn wound healing in fuzzy rats. This study provides preliminary data for further investigations of Compound R in managing burn wounds.
Division of Clinical and Administrative Pharmacy, College of Pharmacy, University of Iowa, Iowa City 52242.
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Noormohamed
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Kumar
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Min
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000503:physiopathology / Q000628:therapy*; D004655:Emulsions; D008297:Male; D016488:Medicine, African Traditional; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000382:microbiology / Q000628:therapy
D004655:Emulsions