Different effects of acute and chronic immobilization stress on plasma testosterone levels in male Syrian hamsters.
Time-course variations in plasma testosterone levels after various periods of immobilization stress (10 min, 30 min, 2 h, 6 h) were examined in male Syrian hamsters. The immobilization stress consisted of placing the animals in a prone position and wrapping them with flexible steel wire gauze. This was done at room temperature. Testosterone levels were determined in blood samples taken after the hamsters were decapitated. Chronic (2 h, 6 h) immobilization stress produced a drastic and enduring fall in plasma testosterone levels. Reduction of plasma testosterone following the 6-h immobilization stress was observed even 18 h after the stress had been relieved. However, acute (10 min, 30 min) immobilization stress did not influence plasma testosterone. These findings indicated that the effect of immobilization stress on plasma testosterone in hamsters was not biphasic, which it is in rats. Further, these results suggest that immobilization stress in hamsters would be a valuable technique with which to investigate the effects of physiological ranges of testosterone on physiological and psychological functions.
Shiseido Research Center, Yokohama, Japan.
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Tsuchiya
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D000818:Animals; D001143:Arousal / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D006224:Cricetinae; D007103:Immobilization / Q000502:physiology*; D008297:Male; D008647:Mesocricetus; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D013739:Testosterone