Use of Norplant contraceptive implants in the immediate postpartum period: safety and tolerance.
OBJECTIVE
Our purpose was to determine the safety and tolerance of levonorgestrel contraceptive implants (Norplant, Wyeth-Ayerst, Philadelphia) when inserted immediately post partum, to document the effects on weight and blood pressure, and to determine the side effects.


METHODS
After vaginal delivery, 250 women were randomized to receive Norplant within 48 hours of delivery (study group) or at the 4- to 6-week postpartum visit (control group). Baseline measurements were recorded and compared with those obtained at the 4- to 6-week follow-up visit. A diary was maintained by patients who recorded bleeding and side effects. Statistical analysis was performed with t test and chi 2 analysis.


RESULTS
There were no episodes of acute postpartum hemorrhage or clinically significant bleeding. Compared with the control group, the immediate group reported significantly more bleeding days (p < 0.01). There was no significant difference between the two groups in the hemoglobin values obtained at 4 to 6 weeks post partum. The immediate insertion group reported significantly more headaches (p < 0.01) and acne (p = 0.01).


CONCLUSIONS
Norplant is well tolerated and should be available for interested patients immediately post partum.
Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte 28232.
D A
DA
Phemister
S
S
Laurent
F N
FN
Harrison
D000152:Acne Vulgaris / Q000139:chemically induced; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D016912:Levonorgestrel / Q000009:adverse effects / Q000494:pharmacology; D049590:Postpartum Period; D011446:Prospective Studies; D014592:Uterine Hemorrhage / Q000503:physiopathology
D016912:Levonorgestrel