[Ubiquinones and the body's antimutagenic defense].
The effects of ubiquinone-10 given in oral doses of 0.2-20 mg/kg on cytogenetic effects of intraperitoneal photrinum (7 and 14 mg/kg), dioxydinum (100 and 300 mg/kg) and cyclophosphanum (20 mg/kg) were studied in the bone marrow metaphasic cells of male C57Bl/6 mice. Ubiquinone-10 (2 to 20 mg/kg) statistically significantly reduced the clastogenic action of these mutagens, except photrinum used in a dose of 7 mg/kg. The antimutagenic effect of the drug was dose-independent and no more than 50%. The findings enable ubiquinone-10 be considered as an endogenous antimutagen. It is suggested that the antimutagenic activity of the compound is due to its antioxidative properties.
V N
VN
Georgiev
A D
AD
Durnev
S B
SB
Seredenin
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D001388:Aziridines / Q000633:toxicity; D003520:Cyclophosphamide / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000633:toxicity*; D011810:Quinoxalines / Q000633:toxicity; D014451:Ubiquinone / Q000494:pharmacology* / Q000502:physiology
D016587:Antimutagenic Agents; D000975:Antioxidants; D001388:Aziridines; D009153:Mutagens; D011810:Quinoxalines; D014451:Ubiquinone; C001077:dioxidine; C007779:fotrin; D003520:Cyclophosphamide; C025204:Ubiquinone Q2
Ubikhinony i antimutagennaia zashchita organizma.