The first reported case of human ciguatera possibly due to a farm-cultured salmon.
This study is an individual case report of an imported cultured salmon which may have caused ciguatera. The individual's documented clinical symptoms, along with our immunological tests and bioassays (hemolytic, mouse toxicity and guinea-pig atrial assays) of the salmon extracts, strongly suggest that the salmon may have contained a ciguatoxin-like toxin (or toxins). The unique ability of the toxin(s) to block the sodium channel of the guinea-pig atrium, however, distinguishes it from ciguatoxin-1 isolated from moray eel liver.
Department of Pathology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822.
J S
JS
Ebesu
H
H
Nagai
Y
Y
Hokama
D000818:Animals; D001681:Biological Assay; D036841:Ciguatera Poisoning; D002922:Ciguatoxins / Q000032:analysis; D005260:Female; D005398:Fisheries; D005517:Foodborne Diseases / Q000175:diagnosis* / Q000473:pathology; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D006801:Humans; D051379:Mice; D012474:Salmon
D002922:Ciguatoxins