Chromosomal aberrations in Nigerians with haematological malignancies: preliminary report.
Cytogenetic studies were carried out on the blood/bone marrow samples of three patients with chronic granulocytic leukaemia (CGL) and one patient with Burkitt's lymphoma. The karyotypes determined were 46, XY, Ph+ for patient O. A; 46, XY, t(9q+, 22q) for T. A. and 46, XX, t(9q+, 22q) for patient E. O. Patient O. L. with Burkitt's lymphoma presented two karyotypes: 46, XY and 46, XY, +18. The results showed that Philadelphia (Ph1) chromosome was detected in all the patients with CGL and a chromosome marker for African Burkitt's lymphoma in the boy with the disease.
Haematology and Immunology Department, Obafemi Awolowo University, Ile-Ife, Nigeria.
M A
MA
Durosinmi
J O
JO
Faluyi
B A
BA
Ogunsanwo
D000328:Adult; D001856:Bone Marrow Examination; D002051:Burkitt Lymphoma / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D010677:Philadelphia Chromosome
D005819:Genetic Markers