[Efficacy of oral midazolam as premedication in adult].
Midazolam was administered as a premedicant to 90 patients aged from 20 to 55 years with ASA status 1 or 2. The patients were divided into 3 groups: group I 10 mg orally, group II 20 mg orally, group III 5 mg intramuscularly. All premedications were given 30 minutes before entering the operating room. The perioperative effects of midazolam on blood pressure, pulse rate, respiratory rate and SpO2 as well as sedative, hypnotic and amnemonic effects were evaluated in these patients. There were no remarkable changes in the blood pressure, pulse rate or respiratory rate. There was no problem on the upper airway tract, but a slight decrease in SpO2 was observed in a few patients. In this study, sedative and hypnotic effects were almost satisfactory. Midazolam produced significant anterograde amnesia, and the amnemonic rate was 66.7% in group I and 86.7% in group II and III. In conclusion, oral midazolam is an effective preanesthetic medication in adult.
Department of Anesthesia, New Tokyo Hospital, Matsudo.
K
K
Kikuchi
A
A
Konishi
Y
Y
Watanabe
D000284:Administration, Oral; D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D011229:Preanesthetic Medication; D011674:Pulse; D012119:Respiration
D008874:Midazolam