Vasopressin mediated vasodilation of cerebral arteries.
The bolus injection of vasopressin into the vertebral artery produced a dose-dependent vasodilation in the major cerebral arteries, detected angiographically, while it elicited a decrease in vertebral blood flow. One nanomol of vasopressin was the optimal dose for producing maximal vasodilation. The basilar, posterior communicating, and internal carotid arteries showed the most dilatation, followed by the middle cerebral, the intracranial portion of the vertebral artery and the anterior spinal artery. The extracranial portion of the vertebral artery was less sensitive to vasopressin. The vasodilation was inhibited by a V1-antagonist and NG-monomethyl-L-arginine. These results suggest that the arteries of the circle of Willis at the base of the brain are more sensitive to nitric oxide release induced by vasopressin compared with other intracranial and extracranial arteries.
Department of Neurosurgery, Nagoya University School of Medicine, Japan.
Y
Y
Suzuki
S
S
Satoh
H
H
Oyama
M
M
Takayasu
M
M
Shibuya
K
K
Sugita
D000758:Anesthesia; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000033:anatomy & histology / Q000187:drug effects*; D002941:Circle of Willis / Q000033:anatomy & histology / Q000187:drug effects; D004285:Dogs; D007269:Injections, Intra-Arterial; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D014664:Vasodilation / Q000187:drug effects*; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology*; D014711:Vertebral Artery / Q000187:drug effects; D019323:omega-N-Methylarginine
D014667:Vasopressins; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine