Preliminary structure determination of the capsular polysaccharide of Vibrio cholerae O139 Bengal Al1837.
Vibrio cholerae O139 Bengal has recently been identified as a cause of epidemic cholera in Asia. In contrast to V. cholerae O1, V. cholerae O139 Bengal has a polysaccharide capsule. As determined by high-performance anion-exchange chromatography and 1H nuclear magnetic resonance analysis, the capsular polysaccharide of V. cholerae O139 Bengal strain Al1837 has six residues in the repeating subunit; this includes one residue each of N-acetylglucosamine, N-acetylquinovosamine (QuiNAc), galacturonic acid (GalA), and galactose and two residues of 3,6-dideoxyxylohexose (Xylhex). The proposed structure is [formula: see text]
Department of Chemistry and Biochemistry, University of Maryland Baltimore County 21228.
L M
LM
Preston
Q
Q
Xu
J A
JA
Johnson
A
A
Joseph
D R
DR
Maneval
K
K
Husain
G P
GP
Reddy
C A
CA
Bush
J G
JG
Morris
D016667:Bacterial Capsules / Q000737:chemistry*; D002240:Carbohydrate Sequence; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D014734:Vibrio cholerae / Q000737:chemistry*
D011135:Polysaccharides, Bacterial