Design of tight-binding human immunodeficiency virus type 1 protease inhibitors.
Vacca
J P
JP
Department of Medical Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486.
D000595:Amino Acid Sequence; D001665:Binding Sites; D003198:Computer Simulation; D015195:Drug Design; D015683:Gene Products, gag / Q000737:chemistry; D015684:Gene Products, pol / Q000737:chemistry; D016333:HIV Protease / Q000737:chemistry* / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D006868:Hydrolysis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D015683:Gene Products, gag; D015684:Gene Products, pol; D017320:HIV Protease Inhibitors; D010455:Peptides; D016333:HIV Protease