Worsening of liver function with fluconazole and review of azole antifungal hepatotoxicity.
OBJECTIVE
To report a case of fluconazole worsening of liver dysfunction.


METHODS
A patient with hepatitis experienced worsening of her liver function when treated with fluconazole for a Candida infection in her urine. Elevations in aspartate aminotransferase, alanine aminotransferase, and total bilirubin concentrations along with increased prothrombin time and activated partial thromboplastin time were noted as early as the second day of therapy. After discontinuation of the fluconazole, the liver parameters returned to their normal baseline level.


CONCLUSIONS
Hepatotoxicity associated with azole antifungal therapy is reviewed. This patient experienced elevations in liver function enzymes; the literature relating to this topic is evaluated.


CONCLUSIONS
It is probable that fluconazole therapy was involved in the worsening of this patient's liver function. Liver function should be monitored during the course of fluconazole therapy in patients with underlying liver dysfunction. It appears from the published reports that HIV-positive patients may be at risk for hepatotoxicity with fluconazole.
Department of Pharmacy, Good Samaritan Hospital, Dayton, OH 45406.
M O
MO
Gearhart
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002177:Candidiasis / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000009:adverse effects*; D006784:Hospitals, Teaching; D006801:Humans; D008107:Liver Diseases / Q000201:enzymology; D008111:Liver Function Tests; D008875:Middle Aged; D014230:Triazoles / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy
D014230:Triazoles; D015725:Fluconazole; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase