Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock.
Interleukin (IL)-10 is a potent immunosuppressant of monocyte/macrophage function and may help control the inflammatory response induced by bacterial infection. To analyze whether IL-10 is detectable in plasma of patients with septic shock and to evaluate its relationship with endotoxin (lipopolysaccharide [LPS])-induced and monocyte/macrophage-induced inflammatory response, plasma IL-10, tumor necrosis factor (TNF)-alpha, IL-1 beta, IL-6, IL-8, LPS, and neopterin were studied in 24 patients with septic shock and in 12 critically ill patients. Eighty-three percent of patients with septic shock and 25% of critically ill patients had detectable levels of IL-10 (P < .001). There was a significant correlation between plasma IL-10, neopterin (r = .72), TNF-alpha (r = .76), IL-6 (r = .68), and IL-8 (r = .61) levels in patients with septic shock. Monocyte/macrophage activation leads to massive secretion of IL-10, which, however, seems to be unable to control the increased production of proinflammatory mediators during septic shock.
Department of Biochemistry, Vall d'Hebron General Hospital, Autonomous University, Barcelona, Spain.
J
J
Gómez-Jiménez
M C
MC
Martín
R
R
Sauri
R M
RM
Segura
F
F
Esteban
J C
JC
Ruiz
X
X
Nuvials
J L
JL
Bóveda
R
R
Peracaula
A
A
Salgado
D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation; D016753:Interleukin-10 / Q000097:blood*; D008070:Lipopolysaccharides / Q000097:blood; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D019798:Neopterin; D011446:Prospective Studies; D012772:Shock, Septic / Q000097:blood / Q000175:diagnosis / Q000276:immunology*
D016207:Cytokines; D008070:Lipopolysaccharides; D016753:Interleukin-10; D001708:Biopterins; D019798:Neopterin