Down syndrome and male fertility: PCR-derived fingerprinting, serological and andrological investigations.
Down syndrome, the most common birth defect causing mental retardation, is characterized by a specific phenotype including subfertility or sterility and hypogonadism in males. In contrast, several females with Down syndrome have borne offspring. Here, a male with trisomy 21 fathering an infant is described. This observation is verified by serological markers, DNA fingerprinting using different DNA micro- or minisatellites and andrological investigations.
Zühlke
C
C
Institut für Humangenetik, Universität Göttingen, Germany.
Thies
U
U
Braulke
I
I
Reis
A
A
Schirren
C
C
D000328:Adult; D016172:DNA Fingerprinting; D004314:Down Syndrome / Q000503:physiopathology*; D005260:Female; D005298:Fertility / Q000235:genetics; D006801:Humans; D008297:Male; D010334:Paternity; D010375:Pedigree; D012661:Semen / Q000166:cytology