Depot drug delivery system for 5-fluorouracil after filtration surgery in the rabbit.
We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) significantly lengthened the survival time of filtration fistulae compared with discs without 5-FU (18 eyes) or no disc (10 eyes) (p < 0.0001). Use of PGLA copolymer impregnated with 5-FU could prove valuable for patients undergoing glaucoma filtering surgery.
Department of Ophthalmology, University of Toronto, ON.
G E
GE
Trope
Y L
YL
Cheng
H
H
Sheardown
G S
GS
Liu
I A
IA
Menon
J G
JG
Heathcote
D S
DS
Rootman
W J
WJ
Chiu
L
L
Gould
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D003228:Conjunctiva / Q000187:drug effects; D016503:Drug Delivery Systems; D018463:Filtering Surgery; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006016:Glycolates; D007773:Lactates; D019344:Lactic Acid; D011108:Polymers; D011817:Rabbits; D011897:Random Allocation
D001672:Biocompatible Materials; D006016:Glycolates; D007773:Lactates; D011108:Polymers; C031149:glycolic acid; D019344:Lactic Acid; D005472:Fluorouracil