[An experimental study on cultivation of human trigeminal ganglionic cell in vitro and its sensitivity to infection of herpes simplex virus type 1].
We firstly report an experimental study on the sensitivity of primary cultural human trigeminal ganglionic cells infected by herpes simplex virus type 1 (HSV-1) in different time-points. The results indicate that the neuron of human trigeminal ganglia is the most sensitive cell type, the antigen of HSV-1 replicates rapidly within the cytoplasm and cell nucleus, the fibroblasts and glia cells are infected partly by the virus. Therefore, perhaps the neuron is the main harboring cell type.
Institute of Ophthalmology, Shandong Academy of Medical Sciences, Qingdao, China.
L
L
Xie
X
X
Dong
S
S
Zhu
D
D
Zhang
B M
BM
Gebhardt
H E
HE
Kaufman
D000956:Antigens, Viral / Q000032:analysis; D002478:Cells, Cultured; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000821:virology; D012668:Trigeminal Ganglion / Q000166:cytology* / Q000821:virology*
D000956:Antigens, Viral