Dysfunctional uterine bleeding in adolescents.
This retrospective, multicenter analysis was conducted on all adolescents admitted to three pediatric hospitals in Montreal, Quebec, Canada, over a 10-year period (1981-1991) with a primary diagnosis of dysfunctional uterine bleeding. The purpose was to assess the frequency of underlying medical disorders and their response to medical therapy. Sixty-one patient charts were identified. Newly diagnosed hematologic abnormalities were found in two patients (one with immune thrombocytopenic purpura and one with acute promyelocytic leukemia). Furthermore, all patients who were evaluated had normal factor VIII levels, partial thromboplastin times and prothrombin times. Twenty-nine percent of the patients had a past history of a significant medical problem. The mean age at presentation was 13.8 +/- 2.1 (SD) years. More than 50% of the patients had a history of irregular bleeding. Most patients (93.4%) responded to medical management. Only five (8.2%) required dilation and curettage. The history of irregular cycles, the early presentation after menarche, the infrequency of hematologic problems but high frequency of significant medical problems led us to conclude that the etiology of dysfunctional uterine bleeding in adolescence is often related to persistent immaturity of the hypothalamic-pituitary-ovarian axis. Medical therapy is highly effective in controlling such bleeding. Dilation and curettage is rarely required.
Institut de médecine de la reproduction de Montréal, Quebec, Canada.
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Desjardins
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Bourque
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Granger
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Hemmings
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Quiros
D000284:Administration, Oral; D000293:Adolescent; D004107:Dilatation and Curettage; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008572:Menarche; D011792:Quebec / Q000453:epidemiology; D017584:Reproductive History; D012189:Retrospective Studies; D014592:Uterine Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy
D004966:Estrogens, Conjugated (USP)