Synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan: a new analogue of heptylphysostigmine (MF 201).
The synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan is described. The compound is structurally related to the cholinesterase inhibitor heptylphysostigmine (MF 201) because the angular methyl group of the esoroline nucleus has been changed into a bridging carbon and the anilinic nitrogen has been replaced by a methylene group. This compound proved to be a potent cholinesterase in vitro inhibitor.
Brufani
M
M
Dipartimento di Scienze Biochimiche, A. Rossi Fanelli, Università La Sapienza, Roma.
Filocamo
L
L
Imbriani
E
E
Lappa
S
S
Mannina
L
L
D001575:Benzomorphans / Q000138:chemical synthesis*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010830:Physostigmine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
C091667:2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan; D001575:Benzomorphans; D002800:Cholinesterase Inhibitors; C052450:physostigmine heptyl; D010830:Physostigmine