Long-term sedation with propofol and green discolouration of the liver.
Propofol has been reported to cause discolouration of urine and hair. A case of green discolouration of the liver is reported in a 56-year-old man after long-term sedation with propofol in the intensive care unit. After discontinuation of propofol the discolouration of the liver disappeared. This phenomenon is due to metabolism of propofol which may lead to a phenolic green chromophore which is conjugated in the liver and excreted in the urine.
Department of Anaesthesia, University of Heidelberg, Germany.
J
J
Motsch
H
H
Schmidt
A
A
Bach
B W
BW
Böttiger
H
H
Böhrer
D056486:Chemical and Drug Induced Liver Injury; D016292:Procedural Sedation / Q000009:adverse effects*; D006801:Humans; D007813:Laparotomy; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010533:Peritoneal Lavage; D019800:Phenol; D010636:Phenols / Q000378:metabolism / Q000652:urine; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000378:metabolism; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D013997:Time Factors
D010636:Phenols; D019800:Phenol; D015742:Propofol