Adhesion and matrix in vertebrate development.
The extracellular matrix supports the adhesion and migration of cells during morphogenesis and influences cell differentiation. Cell interactions with the extracellular matrix are mediated in large part by members of the integrin family of cell-surface receptors. Recent progress in this area has resulted in the identification of multiple integrins, many of which are expressed in position-specific patterns during vertebrate development. The contributions of these receptors to specific developmental events are now being investigated in a variety of systems using a combination of genetic, molecular and immunological approaches.
DeSimone
D W
DW
University of Virginia, Department of Cell Biology, School of Medicine, Charlottesville 22908.
D000663:Amphibians; D000818:Animals; D000906:Antibodies; D002448:Cell Adhesion / Q000235:genetics / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D018390:Gene Targeting; D006801:Humans; D016023:Integrins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D051379:Mice; D016372:RNA, Antisense / Q000235:genetics; D014714:Vertebrates / Q000235:genetics / Q000254:growth & development* / Q000502:physiology
D000906:Antibodies; D016023:Integrins; D016372:RNA, Antisense