Ivermectin detection in serum of onchocerciasis patients: relationship to adverse reactions.
Ivermectin treatment of onchocerciasis patients can be accompanied by adverse reactions. Not much is known concerning the pathogenesis of these reactions. Previous studies have demonstrated that the occurrence and extent of adverse reactions are related to infection intensity. However, some severely infected patients experience relatively few adverse effects. The aim of the present study was to investigate whether this seeming discrepancy could be due to diminished ivermectin absorption. Ivermectin concentrations one and two days after treatment were measured by high-performance liquid chromatography in sera of 71 skin snip-positive onchocerciasis patients (21 without reactions, 25 with mild reactions, 14 with moderate reactions, and 11 with severe reactions). The overall mean +/- SD ivermectin concentrations one and two days after a single oral dose (150 micrograms/kg) were 16.4 +/- 6.4 and 6.6 +/- 3.1 ng/ml, respectively. The overall mean +/- SD half-life was estimated to be 19.9 +/- 8.6 hr. The data presented did not show a relationship between ivermectin concentrations and the grade of adverse reactions.
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
F L
FL
Njoo
W M
WM
Beek
H J
HJ
Keukens
H
H
van Wilgenburg
J
J
Oosting
J S
JS
Stilma
A
A
Kijlstra
D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects* / Q000097:blood* / Q000493:pharmacokinetics; D016015:Logistic Models; D009855:Onchocerciasis / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D012867:Skin / Q000469:parasitology
D007559:Ivermectin