Inhalation MR lymphography: a new method for selective enhancement of the lung hilar and mediastinal lymph nodes.
On MR lymphography, a new approach to the lung hilar and mediastinal nodes was developed in an animal model. Five rabbits were made to inhale iron colloid (cideferron) that was nebulized to aerosol. Two days after inhalation of the agent, the mediastinal lymph nodes decreased in signal on SE 2000/30 and SE 2000/60 images and proved to have iron on histological evaluation, whereas the popliteal nodes did not have any iron. Experimental results indicate that inhalational administration can deliver the agent to the pulmonary lymphatic system and has the potential of lung hilar and mediastinal MR lymphography.
Okuhata
Y
Y
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
Xia
T
T
Urahashi
S
S
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D003102:Colloids; D003287:Contrast Media; D007501:Iron; D008168:Lung / Q000033:anatomy & histology; D008198:Lymph Nodes / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008482:Mediastinum / Q000033:anatomy & histology; D011817:Rabbits
D000336:Aerosols; D003102:Colloids; D003287:Contrast Media; D007501:Iron