Retroviral inhibition by antisense oligonucleotides determined by intracellular stability.
A 15-mer oligodeoxyribonucleotide was found to be efficient toward the Friend retrovirus only when modified or encapsulated in liposomes. The nonmodified oligomer was inefficient. We have measured the intracellular stability of this 15-mer when encapsulated or modified and we have observed a direct relationship between the intracellular stability of the oligonucleotides and their antiretroviral efficiency.
URA 147 CNRS, U 140 INSERM, Institut Gustave Roussy, Villejuif, France.
C
C
Ropert
A
A
Okruszek
P
P
Couvreur
C
C
Malvy
D000998:Antiviral Agents / Q000494:pharmacology*; D001483:Base Sequence; D002460:Cell Line; D004355:Drug Stability; D005622:Friend murine leukemia virus / Q000187:drug effects*; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*
D000998:Antiviral Agents; D016376:Oligonucleotides, Antisense