[HELLP syndrome and manifestation of type I diabetes mellitus in pregnancy].
HELLP syndrome (haemolysis, elevated liver function tests and low platelets) is a multiorganic disease and has been described in combination with pre-eclampsia/eclampsia, but even without symptoms of gestosis. There are signs, that HELLP syndrome represents an "acute status of autoimmunity". Since immune mechanisms play a fundamental role together with other factors in the development of type I diabetes mellitus, a combination of autoimmune reactions could explain the development of type I diabetes during an altered immune status. We report on the course of a pregnancy complicated by HELLP syndrome, which developed type I diabetes mellitus in the same pregnancy. A subsequent pregnancy with adequate diabetes therapy was uncomplicated and without recurrence of HELLP syndrome.
Landesfrauenklinik Salzburg.
D
D
Spitzer
R
R
Weitgasser
H
H
Steiner
A
A
Graf
S
S
Sailer
A
A
Staudach
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology; D001786:Blood Glucose / Q000378:metabolism; D017604:Cesarean Section, Repeat; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D017359:HELLP Syndrome / Q000175:diagnosis* / Q000276:immunology; D006461:Hemolysis / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007332:Insulin Infusion Systems; D008111:Liver Function Tests; D010976:Platelet Count; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000175:diagnosis* / Q000276:immunology
D001323:Autoantibodies; D001786:Blood Glucose; D006442:Glycated Hemoglobin
HELLP-Syndrom und Manifestation eines Typ-I-Diabetes mellitus in der Schwangerschaft.