Concentration of dopamine in plasma, activity of dopamine beta-hydroxylase in serum and urinary excretion of free catecholamines and vanillylmandelic acid in women chronically exposed to carbon disulphide.
The authors studied 140 women, selected at random, aged 22-55, divided into two groups. Group I (control) included 50 women, mean age 40.1 +/- 1.7 years. Group II included 90 women, mean age 39.7 +/- 2.1 years, chronically exposed to 15.6 - 21.84 mg/m3 of carbon disulphide from 0.5 to over 20 years. It was found that women chronically exposed to CS2 showed significantly lower levels of dopamine and lower activities of DBH (p < 0.001), significantly lower urinary excretion of adrenaline (p < 0.001), but insignificantly lower excretion of noradrenaline and vanillylmandelic acid.
Department of Gynecology, Institute of Gynecology and Obstetrics, Pomeranian Medical Academy, Szczecin, Poland.
S
S
Stanosz
D
D
Kuligowski
A
A
Pieleszek
E
E
Zuk
D
D
Rzechuła
D
D
Chlubek
D000328:Adult; D001794:Blood Pressure; D002246:Carbon Disulfide / Q000009:adverse effects*; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D004837:Epinephrine / Q000652:urine*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects*; D011044:Poland; D011897:Random Allocation; D014642:Vanilmandelic Acid / Q000652:urine*
D014642:Vanilmandelic Acid; D004299:Dopamine beta-Hydroxylase; D002246:Carbon Disulfide; D009638:Norepinephrine; D004837:Epinephrine