Studies on rehmanniae radix. I. Effect of 50% ethanolic extract from steamed and dried rehmanniae radix on hemorheology in arthritic and thrombosic rats.
Effects of 50% ethanolic extract (JR-ext) from Chinese Rehmanniae Radix (the steamed and dried root of Rehmannia glutinosa, "Jyuku-Jio" in Japanese) on the hemorheology of inflammatory, thrombosic and intact animals were examined in the in vivo models. JR-ext (200 mg/kg, p.o.) inhibited the reduction of fibrinolytic activity and erythrocyte deformability, the decrease in erythrocyte counts and the increase in connective tissue of the thoracic artery in a chronic inflammatory model, adjuvant-induced arthritis. However, JR-ext was ineffective on the development of edema in the arthritic rats and on acute and chronic inflammation. JR-ext inhibited the reduction of erythrocyte deformability, but not the decrease of coagulative factors in a thrombosic model, endotoxin-induced disseminated intravascular coagulation (DIC). JR-ext also showed a promoting effect on erythrocyte deformability and fibrinolytic activity in intact rats. These results suggest that orally administered JR-ext can prevent an inducement of impediment in the peripheral microcirculation of various chronic diseases through the improvement of hemorheology.
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
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Kubo
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Asano
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Shiomoto
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Matsuda
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood*; D001772:Blood Cell Count / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004487:Edema / Q000473:pathology / Q000517:prevention & control; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D006099:Granuloma / Q000473:pathology; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013927:Thrombosis / Q000097:blood*
D000085:Acetates; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D002351:Carrageenan; D006909:Hydroxyproline