[Possible existence of non-identified anti-leukemic factor in the crude sampling of natural human interferon gamma].
Human natural interferon gamma (IFN-gamma) exerts differentiating and cytocidal effects in vitro on the human myeloblastic leukemia cell line ML-2. The anti-leukemic effects of the crude preparation of IFN-gamma are more intensive than those of the mixture of purified IFN-gamma, IFN-alpha, tumor necrosis factor alpha and lipopolysaccharide, suggesting existence of an unknown anti-leukemic factor in the crude IFN-gamma sample.
Tamura
M
M
Laboratoires Biochimiques Hayashibara, Okayama, Japan.
Nagano
Y
Y
D006801:Humans; D007371:Interferon-gamma / Q000737:chemistry* / Q000494:pharmacology*; D007951:Leukemia, Myeloid / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D007371:Interferon-gamma
Existence possible d'un facteur anti-leucémique non-identifié dans l'échantillon brut d'interféron gamma humain naturel.