Total sialic acid as a tumor marker for oral cancer.
Serum sialic acid levels were measured in 80 healthy subjects, in 60 patients with benign tumors and in 110 patients with oral cancer. It was shown that these levels were significantly elevated in oral cancer patients compared to healthy controls and patients with benign tumors (p < 0.01); they were higher in patients with stage III and stage IV disease than in those with stage I and II disease (p < 0.01). However, no difference was observed between healthy controls and stage I and II cancer patients. The results of this study suggest that the determination of sialic acid levels may be of value in the diagnosis of oral cancer, but its usefulness as an adjunct in clinical staging is limited.
Xing
R D
RD
Department of Oral and Maxillofacial Surgery, 2nd Teaching Hospital, Hebei Medical College, Shijiazhuang - People's Republic of China.
Wang
Z S
ZS
Li
C Q
CQ
Tang
Q Y
QY
Jiang
C B
CB
Zhang
Y Z
YZ
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood* / Q000473:pathology; D019158:N-Acetylneuraminic Acid; D009367:Neoplasm Staging; D012680:Sensitivity and Specificity; D012794:Sialic Acids / Q000097:blood*
D014408:Biomarkers, Tumor; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid