Red cell transfusion therapy in chronic anemia.
This article discusses anemia, the evaluation of symptoms, and the compensatory mechanisms that are brought into play by chronic anemia. The oxygen dissociation curve is described as is the effect of 2,3-DPG on hemoglobin-oxygen binding. Human tolerance to anemia is discussed and the article concludes with proposed transfusion strategies in chronic anemia.
Department of Medicine, Northwestern University Medical School, Chicago, Illinois.
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Rossi
D019794:2,3-Diphosphoglycerate; D000740:Anemia / Q000097:blood / Q000628:therapy*; D002908:Chronic Disease; D004163:Diphosphoglyceric Acids / Q000097:blood; D017707:Erythrocyte Transfusion; D006801:Humans
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate