Optimization of a fed-batch process for production of a recombinant antibody.
Robinson
D K
DK
Merck Research Laboratories, Rahway, New Jersey 07065.
Seamans
T C
TC
Gould
S L
SL
DiStefano
D J
DJ
Chan
C P
CP
Lee
D K
DK
Bibila
T
T
Glazomitsky
K
K
Munshi
S
S
Daugherty
B
B
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000235:genetics; D046508:Culture Techniques / Q000379:methods*; D003587:Cytomegalovirus / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D017930:Genes, Reporter; D005813:Genes, Synthetic; D005822:Genetic Vectors; D005974:Glutamate-Ammonia Ligase / Q000096:biosynthesis / Q000235:genetics; D015483:HIV Antibodies / Q000096:biosynthesis* / Q000235:genetics; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis* / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D010954:Plasmacytoma / Q000473:pathology; D011401:Promoter Regions, Genetic; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis* / Q000235:genetics; D014407:Tumor Cells, Cultured
D000596:Amino Acids; D000911:Antibodies, Monoclonal; D018076:DNA, Complementary; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D011993:Recombinant Fusion Proteins; D005974:Glutamate-Ammonia Ligase