Cytogenetics of cranial base tumors.
Many different tumor types can arise in or invade the skull base. The more common tumors include, but are not limited to, angiofibromas, chondrosarcomas, chordomas, hemangiopericytomas, meningiomas, carcinomas, olfactory neuroblastomas, paragangliomas, pituitary adenomas, and rhabdomyosarcomas. Several of these tumors, including meningiomas, hemangiopericytomas, and rhabdomyosarcomas are characterized by nonrandom cytogenetic abnormalities. In this paper, we review the recognized chromosomal aberrations in cranial base tumors and illustrate the insights that can be gained into the genetic basis of tumor formation using karyotypes from skull base tumors that we have examined. As in tumors in other locations, chromosomal findings may be of diagnostic and prognostic value in cranial base tumors.
Department of Human Genetics, University of Pittsburgh, Pennsylvania.
S M
SM
Gollin
I P
IP
Janecka
D000236:Adenoma / Q000235:genetics / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D002277:Carcinoma / Q000235:genetics / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002813:Chondrosarcoma / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D018304:Esthesioneuroblastoma, Olfactory / Q000235:genetics / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D006393:Hemangiopericytoma / Q000235:genetics / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D007890:Leiomyosarcoma / Q000235:genetics / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000556:secondary; D008577:Meningeal Neoplasms / Q000235:genetics / Q000473:pathology; D008579:Meningioma / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009296:Nasal Cavity; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology; D009669:Nose Neoplasms / Q000235:genetics / Q000473:pathology; D009808:Odontogenic Tumors / Q000235:genetics / Q000473:pathology; D010235:Paraganglioma / Q000235:genetics / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000235:genetics / Q000473:pathology; D010911:Pituitary Neoplasms / Q000235:genetics / Q000473:pathology; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000235:genetics / Q000473:pathology; D012509:Sarcoma / Q000235:genetics / Q000473:pathology; D012888:Skull Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D014407:Tumor Cells, Cultured