A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity.
Seventy natural and synthetic compounds were tested for potential to inhibit mutation induced by 7,12-dimethylbenz(a)anthracene (DMBA) in Salmonella typhimurium strain TM677. Results were compared with their ability to inhibit DMBA-induced preneoplastic lesions in a mouse mammary gland organ culture system. The response mediated by fifty-five of the test compounds was either positive or negative in both test systems, indicating that the combined use of these assays should aid in the discovery of antimutagenic agents that have cancer chemopreventive potential.
Shamon
L A
LA
Program for Collorative Research in the Pharmaceutical Sciences, University of Illinois at Chicago 60612.
Chen
C
C
Mehta
R G
RG
Steele
V
V
Moon
R C
RC
Pezzuto
J M
JM
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016587:Antimutagenic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D009152:Mutagenicity Tests
D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D015127:9,10-Dimethyl-1,2-benzanthracene