Craniopharyngioma: endocrine abnormalities at presentation.
Craniopharyngioma is the most common childhood tumor to involve the hypothalamus and pituitary. Although endocrine disturbances can be found in 80-90% of patients at presentation, only a minority of subjects seek medical attention for an endocrine-related complaint. Hormonal studies, while limited, indicate GH deficiency in 75% of children; deficiencies of LH/FSH (40%), ACTH (25%) and TSH (25%) also are common. In contrast, diabetes insipidus has been noted in only 9-17% of subjects prior to surgery. When possible, full evaluation of pituitary function should be performed; the minimum preoperative evaluation must include testing for and treatment of ACTH-adrenal insufficiency and diabetes insipidus.
Sklar
C A
CA
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
D000309:Adrenal Insufficiency / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D002648:Child; D003397:Craniopharyngioma / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D003919:Diabetes Insipidus / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D010901:Pituitary Function Tests; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery
D010907:Pituitary Hormones