Hyperintense lesions of the globus pallidus on MRI in children with chronic liver disease.
In three children with chronic liver disease of different aetiology without obvious hepatic encephalopathy, bilateral and symmetrical hyperintensity of the globus pallidus in T1-weighted images was found on cranial MRI. Reversibility was shown in one child with autoimmune hepatitis after normalisation of liver function tests under immunosuppressive therapy.


CONCLUSIONS
As central nervous system involvement in liver disease is only partially understood, brain imaging by MRI offers a potential additional tool to further elucidate the incidence and time course of previously undetected brain alterations.
Department of Paediatrics, University Hospital, Düsseldorf, Germany.
A
A
Ballauff
V
V
Engelbrecht
T
T
Voit
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005917:Globus Pallidus / Q000473:pathology*; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies