Differences in plasminogen activator inhibitor 1 activity between blacks and whites may be diet related.
Two matched groups of healthy non-smoking male volunteers between 18 and 23 years old and with a body mass index of 19-24 kg/m2 were selected from urban whites (n = 15) and from rural Vendas (blacks; n = 17). Fasting venous blood samples were collected between 07.00 and 10.00 h, and a validated food frequency questionnaire was administered. The results showed highly significant differences in dietary patterns. Significant differences were observed with regard to serum cholesterol (p < 0.02), percentage high-density lipoprotein cholesterol (p < 0.02), calculated insulin sensitivity index (p < 0.04), and plasma fibrinogen levels (p < 0.03). Tissue plasminogen activator antigen did not differ significantly. The plasminogen activator inhibitor 1 activity was significantly lower (p < 0.0001) in the Vendas than in the whites. It is concluded that diet may be an important determinant of plasminogen activator inhibitor 1 activity.
Jerling
J C
JC
Department of Nutrition, Potchefstroom University for Christian Higher Education, Potchefstroom, South Africa.
Vorster
H H
HH
Oosthuizen
W
W
Silvis
N
N
Venter
C S
CS
D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D044383:Black People; D004032:Diet; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011863:Radioimmunoassay; D012424:Rural Population / Q000706:statistics & numerical data; D013019:South Africa; D011795:Surveys and Questionnaires; D014505:Urban Population / Q000706:statistics & numerical data; D044465:White People / Q000706:statistics & numerical data*
D017395:Plasminogen Activator Inhibitor 1