Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics.
Resistance to beta-lactam antibiotics in some naturally transformable bacterial pathogens has arisen by interspecies recombinational events that have generated hybrid penicillin-binding proteins with reduced affinity for the antibiotics. This type of resistance is of particular concern in pneumococci, in which it is increasing worldwide.
Dowson
C G
CG
Microbial Genetics Group, School of Biological Sciences, University of Sussex, Brighton, UK.
Coffey
T J
TJ
Spratt
B G
BG
D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000235:genetics*; D002999:Clone Cells; D018014:Gene Transfer Techniques; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase / Q000235:genetics*; D010403:Penicillin Resistance / Q000235:genetics*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D011008:Pneumococcal Infections / Q000453:epidemiology; D011995:Recombination, Genetic; D013296:Streptococcus pneumoniae / Q000235:genetics*; D018440:beta-Lactam Resistance / Q000235:genetics
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase