Extracellular matrix gene expression in experimental glomerulonephritis.
Recent studies using animal models of glomerulonephritis indicate that steady-state levels of mRNAs encoding basement membrane proteins are frequently, but not universally, increased in parallel and that mRNAs encoding interstitial matrix proteins represent a separate set of genes that may also display coordinate regulation. A variety of maneuvers that ameliorate progressive glomerulosclerosis may act, at least in part, by suppressing glomerular cell matrix protein gene expression. The observed coordinate regulation of matrix genes may be a consequence of shared genetic regulatory sequences. Future therapies designed to retard glomerulosclerosis may take advantage of similarities among the extracellular mediators and regulatory sequences that influence matrix gene expression.
National Institutes of Dental Research, National Institutes of Health, Bethesda, Maryland.
J B
JB
Kopp
L A
LA
Bruggeman
P E
PE
Klotman
D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D015870:Gene Expression / Q000502:physiology*; D005921:Glomerulonephritis / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis
D012333:RNA, Messenger