[Clinical and experimental studies of feiyaning in treating pulmonary arterial hypertension in cor pulmonale].
40 Patients with chronic cor pulmonale (CCP) were treated with Feiyaning (FYN), a Yiqi Huoxue compound prescription, and ligustrazine (LT) were reported. The results showed that FYN and LT could lower the pulmonary artery pressure (PAP) significantly; decrease the pulmonary vascular resistance (PVR) as well as the consumption of oxygen in cardiac muscle; increase cardiac output (CO); improve some indices in hemorrheology; while PaO2 and SaO2 didn't change apparently. Moreover, lowering of FYN on PAP and PVR were superior to that of LT. The experimental studies showed that LT and injection of FYN could completely inhibit the hypoxia caused increase of PAP and PVR in rats; reduce the hypoxia caused pulmonary artery hypertension (PAH) and improve PVR of rats, as well as increase CO. The effects of FYN were superior to LT's. Although LT and FYN could decrease systemic arterial pressure to certain extent, they didn't induce systemic artery hypotension. It suggest that LT could reduce PAH definitely.
Liu
S M
SM
Dept. of Internal Medicine, Affiliated Hospital, Jinan University Medical College, Guangzhou.
Tang
T Q
TQ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D018592:Cross-Over Studies; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000188:drug therapy* / Q000503:physiopathology; D011719:Pyrazines / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D011719:Pyrazines; C017953:tetramethylpyrazine