[An ultrastructure and proteoglycan study of experimental alkali burned cornea of the rabbit].
A rabbit model of alkali burned cornea was made with 1 mol/L NaOH. On days 1, 3, 7 and 14 after the burn, changes in ultrastructure and the ruthenium red (RR) proteoglycan granules were as follows: (1) The epithelium and endothelium peeled off within day 1. In lightly burned cases, the epithelium regenerated on days 3-7; (2) The collagen fibers of corneal stroma became loose and irregular after the burn and began to recover with recovery of the cornea; (3) The RR proteoglycan granules decreased markedly after the burn, in light cases they increased on day 7 and gradually exceeded the normal amount, and then they reapproached the normal when the cornea was essentially recovered.
Yan
Z G
ZG
Department of Ophthalmology, First Affiliated Hospital, Lanzhou Medical College.
Ge
R C
RC
Zhang
L Z
LZ
D000818:Animals; D002057:Burns, Chemical / Q000378:metabolism* / Q000473:pathology; D003315:Cornea / Q000648:ultrastructure*; D065306:Corneal Injuries; D005126:Eye Burns / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D008297:Male; D011509:Proteoglycans / Q000378:metabolism*; D011817:Rabbits; D012972:Sodium Hydroxide
D011509:Proteoglycans; D012972:Sodium Hydroxide