Rapidly progressive pulmonary alveolar proteinosis in a patient with chronic myelogenous leukemia.
A 46-year-old man with chronic myelogenous leukemia (CML) was admitted to our hospital because of high fever. The chest radiographs showed bilateral groundglass-like infiltrates in the perihilar region. Transbronchial lung biopsy (TBLB) and autopsy revealed PAS-positive granular materials characteristic of pulmonary alveolar proteinosis (PAP). He had received interferon-alpha since the time of CML diagnosis. Busulfan had never been administered. Altered cell-mediated immunity was thought to be closely related to the development of PAP.
Department of Internal Medicine, Kawakita General Hospital, Tokyo.
K
K
Ito
K
K
Iwabe
T
T
Okai
S
S
Kouda
M
M
Tadokoro
T
T
Isiko
D018450:Disease Progression; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000628:therapy; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D011859:Radiography; D013997:Time Factors
D016898:Interferon-alpha