Expression of a novel non-angiotensin II [125I]CGP 42112 binding site in healing wounds of the rat brain.
We characterized a novel non-angiotensin II binding site that is recognized by the angiotensin II AT2 receptor ligand [125I]CGP 42112, in healing brain wounds of adult rats. The binding, which was highest at 3 days after injury, appears to be localized to activated microglia surrounding the wound. The novel CGP 42112 binding site may have a role in the function of microglia and in mechanisms of tissue repair in the brain.
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
M
M
Viswanathan
A M
AM
de Oliveira
F M
FM
Correa
J M
JM
Saavedra
D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D001665:Binding Sites; D001930:Brain Injuries / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D009842:Oligopeptides / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000502:physiology*
D007457:Iodine Radioisotopes; D009842:Oligopeptides; D000804:Angiotensin II; C060894:CGP 42112A