The effect of age on the penetration of fluorescein into the human eye.
The penetration into the eye of fluorescein from a normal drop was found to increase with age and averaged twelve times more in the elderly than in the young. Examination of the literature suggests that this is a result of a greater contact time with the cornea rather than a rise in epithelial permeability.
Department of Ophthalmology, Stanford Medical School, California.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002463:Cell Membrane Permeability; D003315:Cornea / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions
D005452:Fluoresceins; D009883:Ophthalmic Solutions; D019793:Fluorescein