[Inhibitory effects of OK-432 administered orally on colon carcinoma induced by DMH in rats].
Inhibitory effects of OK-432 administered orally on DMH-induced colon tumors in rats were examined. As for the immunological parameter, NK activity was measured. ODC activity and nuclear DNA ploidy pattern of the tumor involved areas were evaluated and the histological examination was done in the process of the occurrence of tumors. Rats were divided into four groups as follows; control group, OK-432 group, DMH group and DMH+OH-432 group. As for the appearance of DMH induced colon tumors, the average numbers of tumors per rat in the DMH+OK-432 group were inhibited significantly compared with those in the DMH group, and the rate of cancer in situ in the DMH+OK-432 group significantly increased compared with that in the DMH group. NK activity of lymphocytes in the spleen and lymph nodes in the colon was increased after the oral administration of OK-432, but it was decreased following the peak activity, and it was lower level than that of the control group. An appropriate oral administration of OK-432 may be effective against chemically induced carcinoma of the colon.
Department of Surgery, Showa University School of Medicine, Tokyo, Japan.
N
N
Yasuda
M
M
Shibusawa
A
A
Tsunoda
K
K
Nakao
F
F
Yoshizawa
N
N
Komatsu
M
M
Kusano
D019813:1,2-Dimethylhydrazine; D000284:Administration, Oral; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D003602:Cytotoxicity, Immunologic; D004127:Dimethylhydrazines; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D010844:Picibanil / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004127:Dimethylhydrazines; D010844:Picibanil; D019813:1,2-Dimethylhydrazine