[Fatal generalized AA amyloidosis in mutilating psoriatic arthropathy].
Autopsy findings are reported of a 51-year-old female patient with a 40-year history of mutilating psoriatic arthritis. As a result of this disease the patient developed reactive amyloidosis (AA-type) with generalized vascular involvement, amyloid kidneys and unusual amyloid goitre. The cause of death was ischaemic left ventricular failure due to massive amyloid deposits in the coronary arteries and left ventricular hypertrophy, the latter resulting from renal hypertension. Thus, amyloidosis and ischaemic heart disease were late complications of the underlying inflammatory disease.
Departement Pathologie, Universität, Zürich.
H
H
Klünemann
J
J
Schneider
R P
RP
Linke
C
C
Stey
S
S
Schröder
D000686:Amyloidosis / Q000473:pathology*; D015535:Arthritis, Psoriatic / Q000473:pathology*; D003327:Coronary Disease / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006042:Goiter / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000473:pathology; D007719:Knee Joint / Q000473:pathology; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D000685:Serum Amyloid A Protein / Q000032:analysis*; D013961:Thyroid Gland / Q000473:pathology
D000685:Serum Amyloid A Protein
Letale generalisierte AA-Amyloidose bei mutilierender Psoriasisarthropathie.