The effect of ethanol upon early development in mice and rats. XIX. The late effect of acute preimplantation intoxication with beer and cognac, on the background of chronic consumption, in mice.
The effect upon late foetal development of acute preimplantation intoxication with beer and cognac, on the background of chronic consumption was investigated in mice (controlled on day 19 of pregnancy), by using the following criteria: mean number of embryos/animal, number of resorptions, mean foetal and placental weight, changes of internal organs (Wilson's sections), skeletal development. The results showed that both beverages applied had a noxious foetal effect, manifested by: a decrease of the mean number of embryos/animal (cognac), an increased late mortality (beer), a decrease of the mean foetal and placental weight (both beverages) and the presence of some structural anomalies (especially after beer consumption). The more marked effect of beer and the correlation of late effects with preimplantation changes are discussed.
Fazakaş-Todea
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Laboratory of Embryology and Teratology, Center of Hygiene and Public Health, Timişoara, Romania.
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001515:Beer / Q000009:adverse effects*; D001755:Blastocyst / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy; D051381:Rats