[Characterization by isotope method of the performance of the pneumatic nebulizer NL9 Atomizer in the production of colistin, tobramycin and amiloride aerosols].
The objective of this study was to assess the performance of a new pneumatic nebuliser NL9 Atomisor. The performance was assessed in terms of particle distribution, fraction nebulised, fraction inhaled and percentage of particles of a diameter of between 1 and 4 microns for the nebulisation of physiological serum, colistin, tobramycin and amiloride. The solutions were nebulised in the approved formula for their reconstitution as used in the clinic after the addition of sodium pertechnetate. The validity of this indirect isotopic method has been shown before. The nebuliser was coupled, during the nebulisation, to a pump respirator with six settings. The fraction nebulised was defined as the percentage of the volume of the solution which had left the aerosol generator at the end of the nebulisation. The fraction inhaled was defined as a percentage of the volume of the solution which was gathered at the end of the nebulisation on a filter placed in the inspiratory circuit of the aerosol generator. The study of the distribution of aerosol particle sizes was carried out using a cascade impactor at ten stages. Each of these parameters was determined in triplicate for the four solutions studied. The nebulised fraction consisted of between 33.5 and 58.6% (mean 49.7 +/- 8.1%). The inhaled fraction consisted of between 14 and 30.4% (mean 24.5 +/- 5.5) and the duration of nebulisation was between 10 and 20 minutes. The MMAD was between 1.6 microns with tobramycin 3.5 microns with physiological serum.(ABSTRACT TRUNCATED AT 250 WORDS)
Diot
P
P
Département des Maladies Respiratoires, Unité d'Evaluation Clinique, CHU Bretonneau, Tours.
Le Pape
A
A
Boissinot
E
E
Lemarié
E
E
D000336:Aerosols; D000584:Amiloride / Q000008:administration & dosage*; D003091:Colistin / Q000008:administration & dosage*; D003550:Cystic Fibrosis / Q000188:drug therapy*; D005069:Evaluation Studies as Topic; D006801:Humans; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D013670:Sodium Pertechnetate Tc 99m / Q000032:analysis*; D013500:Surface Tension; D014031:Tobramycin / Q000008:administration & dosage*
D000336:Aerosols; D000584:Amiloride; D013670:Sodium Pertechnetate Tc 99m; D014031:Tobramycin; D003091:Colistin
Caractérisation par méthode isotopique des performances du nébuliseur pneumatique NL9 Atomisor pour la production d'aérosols de colistine, tobramycine et amiloride.