Effect of bentonite incorporated in a feed ration with tilmicosin in the prevention of induced Mycoplasma gallisepticum airsacculitis in broiler chickens.
A factorial arrangement of tilmicosin and bentonite was evaluated for efficacy in broiler chickens infected with Mycoplasma gallisepticum and correlated to tilmicosin recovery in a feed assay method. Tilmicosin at 300-500 g/ton prevented development of airsacculitis. The addition of 2% bentonite to the ration caused tilmicosin at 300 g/ton to be ineffective in controlling air-sac lesions, whereas 400 and 500 g/ton were moderately effective. Six percent bentonite rendered tilmicosin completely ineffective at all dose levels. There was a direct correlation between the percentage of bentonite in the feed rations, the percentage of the tilmicosin recovered in the assay procedure, and the increased incidence of air-sac lesions.
Animal Science Research Division, Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana 46140.
T R
TR
Shryock
P R
PR
Klink
R S
RS
Readnour
L V
LV
Tonkinson
D000400:Air Sacs; D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents; D001546:Bentonite / Q000008:administration & dosage* / Q000009:adverse effects; D002645:Chickens; D005069:Evaluation Studies as Topic; D018942:Macrolides; D009175:Mycoplasma Infections / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000517:prevention & control*; D012141:Respiratory Tract Infections / Q000517:prevention & control / Q000662:veterinary*; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors
D000900:Anti-Bacterial Agents; D018942:Macrolides; D001546:Bentonite; C052319:tilmicosin; D015645:Tylosin