Oral hairy leukoplakia in nonimmunosuppressed patients. Report of four cases.
Hairy leukoplakia was first described in association with HIV infection. Today hairy leukoplakia has come to represent a sign of immunosuppression and not just of HIV infection. Although molecular mechanisms have not been fully elucidated, Epstein-Barr virus appears to play a significant role in its etiopathogenesis. We present four cases that illustrate that HL may be seen in non-HIV and nonimmunocompromised patients. The use of high potency topical steroids for the treatment of oral vesiculoerosive diseases seems to have been a contributing factor in two of these cases.
Department of Stomatology, University of California San Francisco.
F
F
Lozada-Nur
J
J
Robinson
J A
JA
Regezi
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids; D018023:HIV Seronegativity; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007165:Immunosuppression Therapy; D017403:In Situ Hybridization; D017733:Leukoplakia, Hairy / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D004279:DNA, Viral; D005938:Glucocorticoids