Mathematical modelling of immunotherapy in HIV infection.
The effect of active or passive immunotherapy on HIV infection was simulated using a mathematical model of CD4+ lymphocyte depletion. Permanently effective active immunotherapy increased CD4+ lymphocyte counts to a steady-state level depending on the intensity of the therapy. Active HIV immunization effective for one or more years increased CD4+ lymphocyte counts during the treatment period and prolonged survival substantially; this prolongation exceeded the time interval of therapy duration. Intensive passive immunotherapy by anti-HIV antibodies led to a temporary increase of CD4+ lymphocyte numbers and an apparent prolongation of survival.
Dolezal
J
J
Institute of Information Theory and Automation, Academy of Sciences of the Czech Republic, Praha.
Hraba
T
T
D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D016219:Immunotherapy, Adoptive; D018448:Models, Immunological