[Use of oral macrolide and azalide antibiotics in children with bronchopulmonary diseases].
The therapeutic efficacy of oral macrolides (erythromycin base and midekamycin, macropen) and azalides (azithromycin, sumamed) in the treatment of children with acute and chronic (during the aggravation) bronchopulmonary diseases was studied. The main etiological factors of acute and chronic pneumonia were Streptococcus pneumoniae and Haemophilus influenzae. The proportion of Staphylococcus aureus was high in infants with acute pleuropulmonary inflammations. The susceptibility of the isolates to the antibiotics was found to be high. The results of the trials showed that erythromycin, macropen and azithromycin were efficient in the treatment of acute and chronic pneumonia. The foci of acute pneumonia dissolved after oral administration of the drugs within the same periods as after the use of other parenteral antibiotics. The comparative estimation of the drug efficacy revealed that azithromycin was more active. The ease of the azithromycin administration (in the form of a suspension) in infants and children once a day for a shorter treatment course up to 5 days, high efficacy and no adverse reactions permitted to consider the antibiotic as the most promising antibacterial agent for the treatment of respiratory infections in children in hospitals and outpatient departments.
Sereda
E V
EV
Tatochenko
V K
VK
Katosova
L K
LK
D000284:Administration, Oral; D017963:Azithromycin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000378:metabolism; D004917:Erythromycin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007933:Leucomycins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008171:Lung Diseases / Q000188:drug therapy* / Q000378:metabolism
D007933:Leucomycins; D004917:Erythromycin; D017963:Azithromycin; C026483:midecamycin
Primenenie peroral'nykh makrolidnykh i azalidnykh antibiotikov pri bronkholegochnoĭ patologii u deteĭ.