SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl.
The Src homology domains SH2 and SH3 are modular components present in many signal transduction proteins. They allow rapid formation of stable protein complexes and may also regulate protein function through intramolecular binding events. SH2 domains recognize phosphotyrosyl residues in a specific sequence context, while SH3 domains recognize a PxxP motif and additional residues that mediate binding specificity.
Feller
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SM
Rockefeller University, New York, NY 10021.
Ren
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R
Hanafusa
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H
Baltimore
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D000268:Adhesiveness; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000737:chemistry*; D016315:Proto-Oncogene Proteins c-abl / Q000737:chemistry*; D050737:Proto-Oncogene Proteins c-crk; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology*
D011518:Proto-Oncogene Proteins; D050737:Proto-Oncogene Proteins c-crk; D016315:Proto-Oncogene Proteins c-abl