The role of semicarbazide-sensitive amine oxidase with a high affinity for benzylamine (Bz. SSAO) in the catabolism of histamine in the mesenteric arterial bed of the rat.
In the mesenteric arterial bed of the rat the semicarbazide-sensitive amine oxidase with a high affinity for benzylamine (Bz. SSAO) (E.C. 1.4.3.6) is also able to oxidize histamine. In the perfused mesenteric arterial bed of the rat the complete inhibition of the Bz. SSAO obtained with a specific inhibitor, B24, almost completely reduces the efflux of imidazole acetic acid and increases the relaxing effect of histamine. Bz. SSAO appears to be the only enzyme present in these blood vessels able to catabolize histamine.
Department of Pharmacology, University of Florence, Italy.
F
F
Buffoni
G
G
Banchelli
G
G
Ignesti
R
R
Pirisino
L
L
Raimondi
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism; D006632:Histamine / Q000378:metabolism* / Q000494:pharmacology; D007093:Imidazoles / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000201:enzymology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013618:Tachyphylaxis / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects
D007093:Imidazoles; D011506:Proteins; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D006152:Cyclic GMP; C005954:imidazoleacetic acid