Analysing the sequence diversity of the 5' NC-region of HCV-isolates found in southern Germany.
In this study we compared the nucleotide sequence of the 5' NC-region of the HCV genome isolated from seven patients and two blood donors from Southern Germany. We could identify two very distinct groups of isolates: the first very similar to the HCV prototype sequence (HCV1) with homology ranging from 99.5% to 98.7%; the second showing 91.7% homology to the HCV1. Group 1 isolates could be found in five patients and the two blood donors. Group 2 isolates could be found in the two other patients. Finally, we could observe neither nucleotide insertion nor deletion in the isolates described here.
German Red Cross Blood Bank Ulm, University of Ulm.
M
M
Da Silva Cardoso
S
S
Epple
K
K
Koerner
B
B
Kubanek
D001483:Base Sequence; D014644:Genetic Variation / Q000235:genetics*; D016679:Genome, Viral; D005838:Genotype; D005858:Germany; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D012367:RNA, Viral