A case of hyperalphalipoproteinemia associated with albumin complexing.
We present a 3 year follow up of a new type of hyperalphalipoproteinemia with stable high density lipoprotein (HDL) concentrations around 6.0 mmol/l in a female with persistently elevated erythrocyte sedimentation rate (ESR). By density gradient ultracentrifugation, next to the intensively colored HDL2-fraction, an additional band between HDL3 and the serum proteins was seen consistently. The patient's plasma contained an unique complex of albumin with apoprotein A-I. Her IgM was 3- to 4-fold elevated was not complexed to HDL. Familial forms of hyperalphalipoproteinemia could be excluded. As a presumed reason for the existence of the HDL-albumin complex we found that the patient's post-heparin plasma lipoprotein lipase activity was over 2-fold increased, while that of hepatic lipase was over 2-fold decreased: no common cause for the existence of the albumin complex and the increased concentration of IgM was found.
Department of General Internal Medicine, University Hospital Nijmegen, The Netherlands.
P N
PN
Demacker
R T
RT
Jansen
A G
AG
Hijmans
H P
HP
van Gorp
D000936:Antigen-Antibody Complex / Q000097:blood; D016632:Apolipoprotein A-I / Q000097:blood*; D001799:Blood Sedimentation; D002499:Centrifugation, Density Gradient; D002784:Cholesterol / Q000097:blood; D004586:Electrophoresis; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism*
D000936:Antigen-Antibody Complex; D016632:Apolipoprotein A-I; D007075:Immunoglobulin M; D008075:Lipoproteins, HDL; D012709:Serum Albumin; D002784:Cholesterol; D008071:Lipoprotein Lipase