Cytomegalovirus-induced T-cell proliferation and the development of progressive multifocal leucoencephalopathy following bone marrow transplantation.
Progressive multifocal leucoencephalopathy (PML) is a rare disorder characterized by progressive demyelination within the brain. It is usually fatal and occurs when there are defects in cell-mediated immunity. We report a case of PML which developed following allogeneic bone marrow transplantation. It was preceded by the development of a persistent polyclonal expansion of large granular lymphocytes (LGLs) which appeared to rise as a consequence of cytomegalovirus infection.
Owen
R G
RG
Department of Haematology, Leeds General Infirmary.
Patmore
R D
RD
Smith
G M
GM
Barnard
D L
DL
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001921:Brain / Q000000981:diagnostic imaging; D002455:Cell Division; D003586:Cytomegalovirus Infections / Q000150:complications*; D006801:Humans; D007111:Immunity, Cellular; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology*; D014057:Tomography, X-Ray Computed