[Effect of some drugs on electroacupuncture analgesia and cytosolic free Ca2+ concentration of mice brain].
In this paper, the effects of some analgesic drugs such as corydalis yanhusuo, Angelica dahurica and Analginum on electroacupuncture analgesic function were studied. In the meantime, the concentrations of cytosolic free Ca2+ ([Ca2+]i) in mice hypothalamus (HT) and periaqueductual grey (PAG) were determined by use of the fluorescence dye Fura-2/AM and AR-CM cation measurement system. The results showed that Corydalis yanhusuo obviously strengthened the analgesic function produced by electroacupuncture. Besides, the [Ca2+]i in the two brain regions of mice in these analgesic experiments with electroacupuncture and Corydalis yanhusuo were all decreased (compared with saline control group, P < 0.01), In the same experimental condition, the [Ca2+]i in Angelica dahurica group and Analginum group has no significant difference compared with the control group, the analgesic mechanisms may be different from that of electroacupuncture and Corydalis yanhusuo.
Hu
J
J
Hospital affiliated to Zhenjiang Medical College.
Xie
J
J
Hu
J
J
Zhang
Y
Y
Wang
J
J
Chen
R
R
D015667:Acupuncture Analgesia; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D004177:Dipyrone / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015671:Electroacupuncture; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D017288:Pain Threshold / Q000187:drug effects
D000700:Analgesics; D004365:Drugs, Chinese Herbal; D004177:Dipyrone; D002118:Calcium