[Clinico-pathogenetic substantiation of comprehensive therapy of Klebsiella infection with the syndrome of water diarrhea in infants].
The data on the examination of 70 infants with Klebsiella infection are presented. The patho-chemical disorders in the intestine under the action of Klebsiella were followed up in the time course and the adequacy of the pathogenetic therapy of the antiinflammatory and membrane protective destination was substantiated. The efficacies of the comprehensive therapy with the use of indomethacin, essential and dimephosphone and the therapy with antibacterial drugs such as monomycin, kanamycin, polymyxin and gentamicin administered orally were compared. The laboratory investigations, pharmaco-immunologic tests and clinical time course observations demonstrated the preference of the pathogenetic therapy of the patients with Klebsiella infection at the early stages of the watery diarrhea syndrome, when the functional disorders at the cellular level prevailed over the structural-and-morphological ones. In cases with complications the combined use of the pathogenetic and antibacterial drugs was more efficient.
Kashuba
E A
EA
Orlov
M D
MD
Kniazeva
E F
EF
Argunova
G A
GA
Tiumentseva
T S
TS
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects; D003968:Diarrhea, Infantile / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D007710:Klebsiella Infections / Q000188:drug therapy*; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D010713:Phosphatidylcholines / Q000627:therapeutic use; D012307:Risk Factors; D013577:Syndrome
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009943:Organophosphorus Compounds; D010713:Phosphatidylcholines; C011246:essential 303 forte; C049638:dimephosphon; D007213:Indomethacin
Kliniko-patogeneticheskoe obosnovanie kompleksnoĭ terapii pri klebsielleznoĭ infektsii s sindromom "vodianistoĭ" diarei u deteĭ rannego vozrasta.