Quantitative analysis of 1-naphthol in urine of neonates exposed to mothballs: the value in infants with unexplained anaemia.
In Nigeria, severe NNJ is common in babies exposed to mothballs and other icterogenic agents. High-performance liquid chromatographic (HPLC) method was employed for quantitative analysis of 1 and 2-naphtol in the urine of 50 neonates aged one to 19 days. Five of the 25 babies who had a history of exposure to mothballs, and none of the babies without a history of exposure had 1-naphtol in their urine. The value of 1-naphtol ranged between 0.75 and 11.69 micrograms/ml with mean of 5 +/- 5 micrograms/ml. The overall correlation coefficient (r) between bilirubin values and 1-naphtol was 0.1 while it was 1 in the three G-6-PD deficient infants. The procedure will be very useful in the evaluation of infants with unexplained NNJ, anaemia, acute haemolytic jaundice and haemoglobinuria if naphthalene poisoning is suspected.
Owa
J A
JA
Department of Paediatrics, Obafemi Awolowo University, Ile-Ife.
Izedonmwen
O E
OE
Ogundaini
A O
AO
Ogungbamila
F O
FO
D000740:Anemia / Q000097:blood / Q000139:chemically induced / Q000652:urine*; D001663:Bilirubin / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood / Q000139:chemically induced / Q000652:urine*; D008297:Male; D009281:Naphthalenes / Q000506:poisoning*; D009284:Naphthols / Q000652:urine*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D009281:Naphthalenes; D009284:Naphthols; C029350:1-naphthol; D001663:Bilirubin