[An analysis of the chromosome aberrations in the peripheral blood lymphocytes of workers in the manufacture of pyromellitic dianhydride].
The report covers results of cytogenetic screening of workers engaged into pyromellitic dianhydride production. Occurrence of chromosomal aberrations in peripheral lymphocytes was studied in 42 workers and 35 donors. The group of the workers exposed to pyromellitic dianhydride demonstrated reliably increased occurrence of aberrant metaphases (4.47%) in comparison with the value in the reference group (2.29%). The principles showing formation of chromosomal aberrations were studied, and their dependences on sex, age, length of service and smoking were revealed. The data obtained prove potential mutagenic danger of the stated production. Revealed stabilization of genetic disorders, depending on longer length of service, could be connected with peculiarities of vital cycle of the lymphocyte units studied.
Viktorova
T V
TV
Khustnutdinova
E K
EK
Lobanov
V V
VV
Rafikov
Kh S
KhS
D000328:Adult; D000375:Aging / Q000097:blood / Q000187:drug effects; D001565:Benzoates / Q000009:adverse effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004391:Dust / Q000009:adverse effects; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012727:Sex Characteristics
D001565:Benzoates; D004391:Dust; C012019:pyromellitic dianhydride
Analiz khromosomnykh aberratsiĭ v limfotsitakh perifericheskoĭ krovi rabochikh v usloviiakh proizvodstva piromellitovogo diangidrida.