Hyperglycaemia and survival after haemorrhage.
OBJECTIVE
To assess the relation between the degree of hyperglycaemia during a standard haemorrhage and survival.


METHODS
Prospective laboratory study


METHODS
University department of surgery, Sweden


METHODS
5 groups of 8-12 adult male Sprague-Dawley rats.


METHODS
Different degrees of hyperglycaemia were achieved in the 5 groups of rats (which had been starved for 24 hours) by infusion of the same amount of 0.9% saline, or 5%, 10%, 20% or 30% glucose during a 48% standard haemorrhage over 60 minutes. Blood glucose concentration and packed cell volume were measured every 30 minutes, and mean arterial pressure was monitored constantly.


METHODS
Survival at 7 days.


RESULTS
Increases in blood glucose concentrations during haemorrhage correlated with plasma refill as indicated by reductions in packed cell volume (r = 0.85, p < 0.0001). Both increases in blood glucose concentrations and reductions in packed cell volume were inversely related to blood pressure during haemorrhage (p < 0.0001). The more glucose that was infused, the higher the blood glucose concentration and the better the plasma refill during haemorrhage which correlated with improvement in the rate of survival at 7 days (p < 0.001).


CONCLUSIONS
The ability to mount a hyperglycaemic response is an important prognostic factor in survival after experimental haemorrhage.
Department of Surgery, Karolinska Hospital and Institute, Stockholm, Sweden.
O
O
Ljungqvist
A
A
Alibegovic
D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology* / Q000627:therapeutic use; D006400:Hematocrit; D006470:Hemorrhage / Q000097:blood* / Q000401:mortality* / Q000503:physiopathology / Q000517:prevention & control; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015996:Survival Rate
D001786:Blood Glucose; D005947:Glucose