The angiotensin I-converting enzyme gene polymorphism: implication in hypertension and myocardial infarction.
The angiotensin I-converting enzyme gene is one of the major genes of the renin-angiotensin and kallikrein-kinin systems and is a candidate gene for several cardiovascular diseases for which a genetic predisposition has been established. Based on analysis of the level of the enzyme in plasma, a genetic polymorphism of its expression has been well characterized. Use of a DNA marker on the angiotensin I-converting enzyme gene has shown that the gene polymorphism is located within the angiotensin I-converting enzyme gene itself. This review summarizes the results of various studies of this polymorphism in cardiovascular diseases and the hypotheses that can be proposed to explain this effect.
INSERM, Paris, France.
F
F
Soubrier
F
F
Cambien
D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D009203:Myocardial Infarction / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D007703:Peptidyl-Dipeptidase A