Parasitological appraisal of TFX-thymomodulin effect on the course of intestinal and muscular invasion in mice infected with Trichinella spiralis.
Studies were undertaken to evaluate by parasitological techniques the course of intestinal and muscular invasions in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin (TFX-Th). Studies were conducted on 120 mice of BALB/c and SWISS strains, infected each with a mean invasive dose of 300 T. spiralis larvae. TFX-Th (Thymoorgan GmbH Pharmazie Co. KG, Vienenburg, Germany) was administered subcutaneously at 30 mg/kg body weight. Depending upon duration of TFX-Th administration and stages of intestinal and muscular invasions, three experiments were distinguished in the study. The results indicated that TFX-Th promoted eradication of larvae from muscles, whether administered at the early of the late stage of T. spiralis invasion.
Department of Parasitic and Tropical Diseases, University of Medical Sciences, Poznań, Poland.
M
M
Iwanow
D000818:Animals; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D007814:Larva / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018482:Muscle, Skeletal / Q000469:parasitology; D011716:Pyrantel Pamoate / Q000627:therapeutic use; D013949:Thymus Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D017160:Trichinella spiralis / Q000187:drug effects* / Q000254:growth & development; D014235:Trichinellosis / Q000188:drug therapy*
C019108:TFX; D013949:Thymus Extracts; D011716:Pyrantel Pamoate; C051006:thymomodulin