Orthodontic rare earth magnets--in vitro assessment of cytotoxicity.
The aim of this study was to assess and compare in vitro the cytotoxic effects of uncoated and parylene-coated rare earth magnets, used in orthodontics. Cytotoxicity of samarium-cobalt magnets (SmCo5 and Sm2Co17) and neodymium-iron-boron magnets (Nd2Fe14B) was assessed by two in vitro methods, the millipore filter method and an extraction method. Orthodontic stainless steel brackets served as controls. Uncoated SmCo5-magnets showed high cytotoxicity while uncoated Sm2Co17-magnets demonstrated moderate cytotoxicity. Uncoated neodymium-iron-boron magnets, as well as parylene coated Sm2Co17-magnets and parylene-coated neodymium-iron-boron magnets, showed negligible cytotoxicity. Short-term exposure to a static magnetic field did not cause any cytotoxic effect on the cells.
Tandregleringskliniken (Orthodontic Clinic), Hässleholm, Sweden.
L
L
Bondemark
J
J
Kurol
A
A
Wennberg
D000818:Animals; D002478:Cells, Cultured; D003343:Corrosion; D003722:Dental Alloys / Q000633:toxicity*; D005347:Fibroblasts / Q000187:drug effects; D008280:Magnetics; D008422:Materials Testing; D008674:Metals, Rare Earth / Q000633:toxicity*; D051379:Mice; D008851:Micropore Filters; D009354:Neodymium / Q000633:toxicity; D009499:Neutral Red / Q000032:analysis; D009967:Orthodontic Appliances; D011108:Polymers; D012493:Samarium / Q000633:toxicity; D013499:Surface Properties; D014992:Xylenes
D003722:Dental Alloys; D008674:Metals, Rare Earth; D011108:Polymers; D014992:Xylenes; C011055:parylene; D009499:Neutral Red; D009354:Neodymium; D012493:Samarium