Stress, antidepressant drugs, and the locus coeruleus.
This review presents a synthesis of a large body of seemingly inconsistent literature on the role of the locus coeruleus-norepinephrine (LC-NE) system and the corticotropin-releasing hormone (CRH)-median eminence system in mediating the CNS effects of stress and the therapeutic effects of antidepressant drugs. The clinical implications of these findings for the etiology and treatment of stress-related psychiatric disorders such as depression will be discussed.
Section on Functional Neuroanatomy, NIMH, Bethesda, MD 20892.
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Brady
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D006801:Humans; D008125:Locus Coeruleus / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology
D000928:Antidepressive Agents; D009638:Norepinephrine