Diuresis and natriuresis in non-seizing and in kindled rats from a genetically audiogenic susceptible strain.
Audiogenic seizures are evoked by acoustic stimulation in susceptible (S) but not in resistant (R) rats. Repeated audiogenic seizures recruit limbic areas, a model called audiogenic kindling. In order to evaluate excretory patterns (urinary volume, Na+ and K+ excretion), S and R animals were non-stimulated, submitted to one (acute) or 10 (kindled) stimulations or to two aqueous overloads (5% b.w.). Non-stimulated S animals displayed a significant increase (p < 0.05) in Na+ excretion at 60, 80, 100 and 120 min. Acutely stimulated S animals showed greater natriuresis than non-stimulated animals at 40, 60, 80 and 100 min. Kindled S animals displayed the greatest natriuresis (p < 0.005) at 40, 60, 80, 100 and 120 min and the highest diuretic response (p < 0.05) at 40, 60 and 80 min. Abnormalities of the endogenous hydroelectrolytic profile of non-stimulated S animals and their overt expression in kindled rats may be related to alterations in neuroendocrine systems regulating hydroelectrolytic balance, in addition to the long-lasting effects of kindled seizures.
Neurophysiology and Experimental Neuroethology Laboratory, Ribeirão Preto School of Medicine, University of São Paulo, Brazil.
N
N
Garcia-Cairasco
L C
LC
Reis
V C
VC
Terra
J A
JA
Oliveira
J
J
Antunes-Rodrigues
D000161:Acoustic Stimulation; D000818:Animals; D004231:Diuresis / Q000502:physiology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008032:Limbic System / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000502:physiology*; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000235:genetics / Q000652:urine*
D011188:Potassium