Detection and diagnostic interpretation of amphetamines in hair.
A review with 22 references on detection and incorporation of amphetamines in hair is presented. This review deals with the detection, incorporation into hair, behavior in the hair shaft, confirmation of past drug use and diagnosis of dependence mainly regarding amphetamine and methamphetamine, along with methoxyphenamine, methylenedioxymethamphetamine, bromomethamphetamine, deprenyl, benzphetamine, fenproporex and mefenorex. First, pretreatment, extraction and analytical methods for amphetamines in hair using immunoassay, HPLC and GC/MS are discussed. This is followed by sections describing the animal experiments, incorporation rates of amphetamines from blood to hair and relationship between drug history and drug distribution in hair. Finally, the diagnosis of amphetamine dependence and confirmation of methamphetamine baby by hair analysis is discussed. The paper concludes with a brief outlook.
National Institute of Health Sciences, Tokyo, Japan.
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Nakahara
D000662:Amphetamines / Q000032:analysis* / Q000493:pharmacokinetics; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007118:Immunoassay; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D008722:Methods; D011247:Pregnancy; D019966:Substance-Related Disorders / Q000175:diagnosis
D000662:Amphetamines