[Estimation of 24-h excretion of some promotors and inhibitors of crystallization and degree of urine saturation with calcium oxalate in calcium urinary calculi].
The aim of the study was to estimate the renal citrate excretion in basal condition and to find out the relationship between their excretion and excretion of calcium, oxalate, magnesium and phosphate in patients with calcium stone disease and in control group. In 93 patients with urolithiasis and 46 healthy subjects 24-h excretion of calcium, magnesium, oxalate, phosphate and citrate as well as the degree of urine saturation with calcium oxalate was evaluated. 24-h renal excretion of calcium was significantly higher in patients with urolithiasis than in control group (p < 0001). Excretion of magnesium, phosphate and oxalate were'nt significantly different between patients with urolithiasis and healthy subjects. Daily excretion of citrate was significantly lower in patients with calcium stone disease (p < 0.01) and the degree of urine saturation with calcium oxalate was significantly higher in this group (p < 0.001). Hypocitraturia was observed in 61.3% stone-formers. A significant positive correlation was observed between excretion of citrate and calcium (r = 0.2760 p < 0.01) as well as citrate and oxalate (r = 0.5310 p < 0.001) in patients with urolithiasis.


CONCLUSIONS
1. In 61.3% of patients with urolithiasis the daily citrate excretion was reduced. In 50% of patients with urolithiasis and reduced citrate excretion "idiopathic" hypocitraturia was recognized. The daily citrate excretion was reduced in 70.2% of stone-formers with infected urine. 2. The positive correlation between 24-h excretion of calcium and citrate suggests that high excretion of lithogenic factor is accompanied by high excretion of this inhibitor of crystallization.
Kliniki Nadciśnienia Tetniczego Instytutu Kardiologii AM w Poznaniu.
A
A
Boruczkowska
D000328:Adult; D002118:Calcium / Q000032:analysis*; D002129:Calcium Oxalate / Q000652:urine*; D002951:Citrates / Q000652:urine*; D003460:Crystallization; D005260:Female; D006801:Humans; D008274:Magnesium / Q000652:urine; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000652:urine; D014545:Urinary Calculi / Q000737:chemistry / Q000652:urine*
D002951:Citrates; D010710:Phosphates; D002129:Calcium Oxalate; D008274:Magnesium; D002118:Calcium
Ocena wydalania niektórych prekursorów złogów kamiczych i inhibitorów krystalizacji oraz stopnia nasycenia moczu szczawianem wapnia w wapniowej kamicy moczowej.