Response to glucagon in imipramine overdose.
A 25-year-old woman, severely hypotensive following a massive imipramine overdose, had an immediate and sustained rise in blood pressure following intravenous glucagon (10 mg bolus followed by an infusion of 10 mg over 6 h). The QRS interval on the electrocardiogram shortened from 129 to 89 msec. Glucagon should be considered in hypotension following tricyclic antidepressant overdose; it may also be antiarrhythmic.
Poisons Unit, Guy's Hospital, London, United Kingdom.
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Sener
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Gabe
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Henry
D000328:Adult; D003975:Diazepam / Q000627:therapeutic use; D062787:Drug Overdose / Q000188:drug therapy; D004562:Electrocardiography; D005260:Female; D005934:Glucagon / Q000627:therapeutic use*; D006801:Humans; D007099:Imipramine / Q000506:poisoning*; D007262:Infusions, Intravenous; D012640:Seizures / Q000188:drug therapy; D013406:Suicide, Attempted
D005934:Glucagon; D007099:Imipramine; D003975:Diazepam