[Structure and function of apolipoproteins].
Plasma lipoproteins are macromolecular complexes that transport hydrophobic lipids, cholesteryl ester, and triglycerides, in their cores. Regulation of the plasma levels of the major lipoproteins, very low density lipoprotein (VLDL), low density lipoprotein (LDL), and high density lipoprotein (HDL) is complex, but the rate of secretion of these lipoproteins, and their accompanying apolipoproteins, are clearly key factors in this process. Apo B is the major apolipoprotein of VLDL and LDL, and plays a key role in assembling VLDL as well as in LDL receptor mediated catabolism of LDL. Apo E is the major apolipoprotein of chylomicron remnant and mediates the recognition by remnant receptor, VLDL receptor as well as LDL receptor. Apo A-I and apo C II are well known as activators of LCAT and LPL, respectively. The purpose of this article is to summarize the current information available concerning the relationship between the structure and function of apolipoproteins.
1st Dept. of Internal Medicine, Teikyo University School of Medicine.
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Teramoto
D000595:Amino Acid Sequence; D001053:Apolipoproteins / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D011485:Protein Binding
D001053:Apolipoproteins; D008074:Lipoproteins