Bronchoprotective role for endogenous prostaglandin E2.
The possibility that impaired production of bronchoprotective factors contributes to the pathogenesis of asthma cannot be excluded. Prostaglandin E2 (PGE2) could be such a factor. It is a dominant cyclo-oxygenase product of airway epithelium and smooth muscle; it has inhibitory effects on inflammatory cells and pathways involved in bronchoconstriction at concentrations known to occur in the airway; inhalation of PGE2 has considerable bronchoprotective effects in patients with asthma; and manoeuvres that increase or decrease endogenous production of PGE2 have beneficial and deleterious effects on airway function.
Division of Respiratory Medicine, Nottingham University, City Hospital, UK.
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Pavord
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Tattersfield
D001249:Asthma / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000502:physiology; D015232:Dinoprostone / Q000502:physiology*; D006801:Humans
D015232:Dinoprostone