[Inhibitory effects of fifteen kinds of Chinese herbal drugs, vegetables and chemicals on SOS response].
Effects of 15 kinds of herbal drugs, vegetables and chemicals on lex-dependent sfi-SOS response were determined by micropersistent and/or pulse models induced by 4-Nitroquinoline-N-oxide (4NQO) and Mitomycin C (MMC) in Escherichia coli(E. coli) PQ37 and PQ35, respectively. Results showed the water extract of Rhizoma Polygonati (RP), Fructus Chebulae (FC), Radix Polygoni Multiflori (RPM), Fructus Ligustri Lucidi (FLL), Bulbus Fritillariae Thunbergii (BFT), shell of water chestnut with a pedicle, Chinese chives juice, and solutions of 5-Fluorouracil, Tannic acid and garlicin could inhibit SOS responses with a dose-response relationship and suggested the inhibitory effects took place both inside and outside E. coli cells. Water extract of FC, FLL, BFT, shell of water chestnut with a pedicle, Chinese chives juice and solution of 5-Fluorouracil and Tannic acid could intracellularly inhibit SOS responses induced by MMC in E. coli PQ35, and acetone extract of Grifola Frondosa (GF) could extracellularly inhibit SOS responses in E. coli PQ37 and intracellularly in PQ35 induced by 4NQO or MMC. Water extract of raw hawthorn. Radix Angelicae Duhuricae (RAD), Radix Ophiopogonis (RO), and 5-Fluorodeoxyuridine could extracellularly inhibit SOS responses induced by 4NQO in E coli PQ37. The possible mechanisms of intracellular inhibition and antidamage repair were discussed in the paper.
Department of Pathophysiology, Zhejiang Medical University, Hangzhou.
Z C
ZC
Jin
J
J
Qian
D015112:4-Nitroquinoline-1-oxide; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004926:Escherichia coli / Q000235:genetics; D005472:Fluorouracil / Q000494:pharmacology; D016685:Mitomycin; D010936:Plant Extracts / Q000494:pharmacology; D013014:SOS Response, Genetics / Q000187:drug effects*; D014675:Vegetables
D016587:Antimutagenic Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D016685:Mitomycin; D015112:4-Nitroquinoline-1-oxide; D005472:Fluorouracil