Effect of subacute toluene administration on the enkephalinergic neuromodulatory system in rats and protective action of ganglioside treatments.
Gangliosides perform protective functions in the central nervous system. This paper describes a study of the effect of ganglioside administration on toluene neurotoxicity. Rat brain met-enkephalin immunostaining in the central amygdaloid nuclei showed changes in rats treated simultaneously with gangliosides and toluene with respect to rats treated with toluene alone. It is suggested that gangliosides prevent toluene neurotoxicity at this level, leading to hypothetical neurobehavioral changes.
Department of Physiology Medical School, University of the Basque Country, Bilbao, Spain.
J M
JM
De Gandarias
E
E
Echevarria
R
R
Serrano
J
J
Irazusta
L
L
Casis
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000187:drug effects / Q000378:metabolism*; D005732:Gangliosides / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014050:Toluene / Q000008:administration & dosage / Q000494:pharmacology*
D005732:Gangliosides; D014050:Toluene; D004744:Enkephalin, Methionine