[Ketorolac protection in damage due to myocardial ischemia and reperfusion].
This study shows that the nonsteroidal anti-inflammatory drug. Ketorolac, has an ionophore-like action for calcium, such a drug may transfer calcium through an hydrophobic phase. This property does not affect the respiratory rate of mitochondria. These results indicate that the ionophoretic effect is not due to an uncoupling action of Ketorolac. The effect of this compound was tested in a reperfusion model where it was observed that Ketorolac (1 mg/Kg weight) administered 30 min before an ischemic period was induced, reverts the arrhythmic effect of reperfusion. These results are in agreement with the analysis of the plasmatic concentrations of the enzymes creatine kinase and lactic dehydrogenase. It was found that the levels of such enzymes were lower in Ketorolac treated group, than in the untreated one. The results clearly indicate that Ketorolac prevents from the myocardial damage induced by reperfusion, probably by avoiding calcium overload in myocytes.
Departamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez.
J
J
Pichardo
R
R
Chávez
C
C
Bravo
C
C
Zazueta
E
E
Chávez
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007476:Ionophores / Q000494:pharmacology / Q000627:therapeutic use*; D020910:Ketorolac; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D017202:Myocardial Ischemia / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D007476:Ionophores; D014046:Tolmetin; D002118:Calcium; D020910:Ketorolac
Protección por Ketorolac en el daño producido por isquemia y reperfusión miocardica.