Prolongation of the prothrombin time after organophosphate poisoning.
Prolongation of the prothrombin time owing to a transient reduction in factor VII activity is described in a 14-month-old child with organophosphate poisoning. Correction after vitamin K administration suggested an organophosphate-related effect on vitamin K-dependent factor VII activity. Historically, coagulation screening has not been routinely recommended after organophosphate intoxications. We suggest, however, that routine screening in such patients may be important. A brief review of organophosphate poisoning and the unique features of our case are presented.
Murray
J C
JC
Section of Hematology-Oncology, Texas Children's Hospital, Houston 77030.
Stein
F
F
McGlothlin
J C
JC
McClain
K L
KL
D000110:Acetylcholinesterase / Q000097:blood; D005167:Factor VII; D005260:Female; D006801:Humans; D007223:Infant; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000188:drug therapy*; D011517:Prothrombin Time; D014812:Vitamin K / Q000627:therapeutic use*
D014812:Vitamin K; D005167:Factor VII; D000110:Acetylcholinesterase