[The effect of changes in the cultivation conditions on the amplification of different Mycoplasma pneumoniae genes].
In experiments carried out with the use of the polymerase chain reaction the inhibition of the amplification of several regions of M. pneumoniae genome, depending on the conditions of their cultivation, has been observed. We suggest that protein, selectively binding with individual sites of DNA, is capable of inhibiting the expression of genes coding pathogenicity factors and thus contributes to the transformation of mycoplasmas into persistent forms.
Zigangirova
N A
NA
Rakovskaia
I V
IV
Gintsburg
A L
AL
Prozorovskiĭ
S V
SV
D002876:Chromosomes, Bacterial / Q000235:genetics; D003470:Culture Media; D017931:DNA Primers; D004269:DNA, Bacterial / Q000235:genetics; D005784:Gene Amplification; D005798:Genes, Bacterial / Q000235:genetics*; D006801:Humans; D009177:Mycoplasma pneumoniae / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D012692:Serial Passage
D003470:Culture Media; D017931:DNA Primers; D004269:DNA, Bacterial
Vliianie izmeneniĭ usloviĭ kul'tivirovaniia na amplifikatsiiu razlichnykh genov Mycoplasma pneumoniae.