Nephrotoxicity of nonsteroidal anti-inflammatory drugs.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are important therapeutic agents in the management of rheumatologic disorders and other pain syndromes. Over the counter availability of the drugs has expanded the usage of the drugs. This article reviews the nephrotoxicity of these drugs, with some emphasis on NSAID-related proteinuria. Although reversibility of renal involvement upon drug discontinuance is the rule, progression to end-stage renal disease has occurred. A proposed guideline for monitoring renal impairment in low- and high-risk patients is also presented.
Department of Internal Medicine, Veterans Affairs Medical Center, Dallas, Tex.
J
J
Baisac
W L
WL
Henrich
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D011507:Proteinuria / Q000139:chemically induced; D012307:Risk Factors; D013577:Syndrome
D000894:Anti-Inflammatory Agents, Non-Steroidal