Effect of bendazac lysine on lens and retina in diabetics.
The possible beneficial effects on the lens and retina which Bendazac Lysine may have in the treatment of adult diabetic patients were investigated. Twenty patients, ranging in age from 54.80 +/- 5.86 years old, were studied. The average duration of the diabetes was 11.32 +/- 4.10 years. Thirteen patients had background retinopathy. The metabolic controls carried out during the study were satisfactory (HbA1 < 11%). Bendazac Lysine (500 mg three times a day) was administered for 6 months. Blood-retinal barrier permeability (VPR and VPRt) and lens transmittance (t) were evaluated prior to and 6 months after treatment by fluorophotometry. No statistically significant differences between the pre- and post-treatment values of the retina permeability were observed, however, there was a statistically significant improvement (p < 0.05) (initial value: t = 0.813 +/- 0.040 and final value: t = 0.823 +/- 0.037) in the lens transmittance. The authors conclude that Bendazac Lysine has a beneficial effect on the lens in the diabetic adult although no improvement in the permeability of the blood-retinal barrier has been observed.
San Carlos University Hospital, R. Castroviejo Ophthalmic Research Center Complutense University, Madrid, Spain.
J M
JM
Benitez del Castillo
I
I
Jimenez-Alfaro
P
P
Ortega
A
A
Castillo
D
D
Diaz
N
N
Toledano
J
J
Garcia-Sanchez
D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001813:Blood-Retinal Barrier / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000150:complications / Q000503:physiopathology; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D007191:Indazoles / Q000008:administration & dosage / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000187:drug effects* / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007191:Indazoles; C036067:bendazac lysine