Association of neuromyotonia with peripheral neuropathy, myasthenia gravis and thymoma: a case report.
A case of neuromuscular hyperactivity syndrome associated with a thymoma, high serum titres of anti-acetylcholine receptor and anti-DNA antibodies is reported. The study of peripheral nerve conduction revealed a peripheral neuropathy. Repetitive stimulation showed a decrease in the fifth M response. Myasthenic symptoms were anamnestically reported but were absent at clinical observation. The clinical picture and EMG examination improved after phenytoin administration.
Divisione di Neurologia, Ospedale di Gallarate, Italia.
M
M
Perini
A
A
Ghezzi
P F
PF
Basso
R
R
Montanini
D001323:Autoantibodies / Q000032:analysis; D004247:DNA / Q000276:immunology; D004576:Electromyography; D004594:Electrophysiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D009222:Myotonia / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D010672:Phenytoin / Q000627:therapeutic use; D011950:Receptors, Cholinergic / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology; D013945:Thymoma / Q000150:complications* / Q000503:physiopathology; D013953:Thymus Neoplasms / Q000150:complications* / Q000503:physiopathology
D001323:Autoantibodies; D011950:Receptors, Cholinergic; D010672:Phenytoin; D004247:DNA