[Effects of inorganic fluoride, inhalation time and dosage of sevoflurane on renal function during sevoflurane anesthesia of long duration].
In sevoflurane anesthesia of long duration, we studied correlations with renal function of the area under the curve (AUC), rate of decrease and maximum level of serum inorganic fluoride (F), sevoflurane dosage, and duration of administration. In 15 neurosurgical patients, we measured serum and urine levels of F, blood urea nitrogen (BUN), creatinine, serum and urine beta 2-microglobulin (BMG), and urine N-acetyl-beta-D-glucosaminidase (NAG). AUC and the rate of decrease of serum F were calculated. There were no correlations among the maximum level, AUC, the rate of decrease of serum F, sevoflurane dosage, duration of administration, BUN, creatinine, BMG, and NAG. It is concluded that in sevoflurane anesthesia of long duration, F, sevoflurane dosage and duration of administration do not affect renal function.
Department of Anesthesiology, JR Tokyo General Hospital.
T
T
Nishiyama
M
M
Nagase
H
H
Tamai
S
S
Watanabe
A
A
Hirasaki
D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D004987:Ethers / Q000008:administration & dosage*; D005260:Female; D005459:Fluorides / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D009493:Neurosurgery; D000077149:Sevoflurane; D013997:Time Factors
D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D005459:Fluorides