Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics.
Resistance to beta-lactam antibiotics in some naturally transformable bacterial pathogens has arisen by interspecies recombinational events that have generated hybrid penicillin-binding proteins with reduced affinity for the antibiotics. This type of resistance is of particular concern in pneumococci, in which it is increasing worldwide.
Microbial Genetics Group, School of Biological Sciences, University of Sussex, Brighton, UK.
C G
CG
Dowson
T J
TJ
Coffey
B G
BG
Spratt
D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000235:genetics*; D002999:Clone Cells; D018014:Gene Transfer Techniques; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase / Q000235:genetics*; D010403:Penicillin Resistance / Q000235:genetics*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D011008:Pneumococcal Infections / Q000453:epidemiology; D011995:Recombination, Genetic; D013296:Streptococcus pneumoniae / Q000235:genetics*; D018440:beta-Lactam Resistance / Q000235:genetics
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase