Dual infections with Staphylococcus aureus and Streptococcus pyogenes causing toxic shock syndrome. Possible synergistic effects of toxic shock syndrome toxin 1 and streptococcal pyrogenic exotoxin C.
We describe a 35-year-old woman with clinical, microbiologic, and serologic findings suggesting that the patient developed toxic shock syndrome as a result of dual infections caused by toxin-producing strains of Staphylococcus aureus and Streptococcus pyogenes. Certain aspects of the pathogenesis of this toxin-related syndrome are reviewed.
Department of Medicine, University of Tennessee Medical Center at Knoxville 37920-6999.
R J
RJ
Smith
P M
PM
Schlievert
I M
IM
Himelright
L M
LM
Baddour
D000328:Adult; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins / Q000009:adverse effects / Q000494:pharmacology*; D005098:Exotoxins / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008565:Membrane Proteins; D012698:Serologic Tests; D012772:Shock, Septic / Q000175:diagnosis / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000150:complications* / Q000175:diagnosis; D013211:Staphylococcus aureus / Q000472:pathogenicity; D013290:Streptococcal Infections / Q000150:complications* / Q000175:diagnosis; D013297:Streptococcus pyogenes / Q000472:pathogenicity; D018089:Superantigens
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; D005098:Exotoxins; D008565:Membrane Proteins; C117980:SpeA protein, Streptococcus pyogenes; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; C027951:erythrogenic toxin