Tear concentrations of topically applied ciprofloxacin.
An open-label study of 20 normal, healthy volunteers was conducted to determine the tear concentrations after topical ocular application of ciprofloxacin 0.3% ophthalmic solution (Ciloxan). Tear samples were collected on Schirmer tear strips at 30 min, 2, 3, and 4 h, and were analyzed for ciprofloxacin using reverse-phase high-performance liquid chromatography. The results of this study showed the mean concentration, 4 h after dosing of ciprofloxacin, to be 16.0 micrograms/ml with 95% confidence limits of 8.15 and 23.79. It is concluded that concentrations of ciprofloxacin in tears were significantly greater than the minimum inhibitory concentrations for 90% of strains tested commonly reported for a majority of potential pathogens (i.e., < or = 2 micrograms/ml) 4 h after a single application of ciprofloxacin ophthalmic solution 0.3%.
Medical and Surgical Eye Care, San Luis Obispo, California 93401.
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Limberg
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Buggé
D000287:Administration, Topical; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009883:Ophthalmic Solutions; D013666:Tears / Q000378:metabolism*
D009883:Ophthalmic Solutions; D002939:Ciprofloxacin