Age and tolerance to secondary ischemia in rat epigastric flaps.
The use of microvascular procedures is increasing as the population continues to age. The purpose of this study was to observe the survival of skin flaps after ischemic injury. Skin flaps (n = 50) underwent either 3 hours of primary (1 degree) or secondary (2 degrees) venous occlusion in young (2-3 mo) and old (18-22 mo) rats. Skin flap survival was assessed on postoperative day 7. Survival rates for young and old after 3 hours of 1 degree ischemia was 100% and 90% (ns). Survival rats for young and old after 2 degrees ischemia were 67% and 47% (ns).
Division of Plastic Surgery, University of Mississippi School of Medicine, Jackson.
M F
MF
Angel
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AM
Ress
L R
LR
Amiss
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Morgan
D000375:Aging / Q000502:physiology*; D000818:Animals; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013524:Surgical Flaps / Q000473:pathology / Q000502:physiology*; D013997:Time Factors; D014022:Tissue Survival