Aromatase activity in an estrogen-producing adrenocortical carcinoma in a young man.
We report on a 19-year-old man with adrenocortical adenoma producing an excessive amount of estrogen. Determination of aromatase activity of the carcinoma tissue revealed its marked enhancement compared with that of 3 normal adrenal glands and the adipose tissue. The enhanced activity of aromatase was mainly responsible for the overproduction of estrogen in the adrenocortical carcinoma of our case.
Kimura
M
M
Department of Urology, Sapporo Medical University School of Medicine, Japan.
Itoh
N
N
Tsukamoto
T
T
Kumamoto
Y
Y
Takagi
Y
Y
Mori
Y
Y
D000306:Adrenal Cortex Neoplasms / Q000201:enzymology* / Q000378:metabolism; D018268:Adrenocortical Carcinoma / Q000201:enzymology* / Q000378:metabolism; D000328:Adult; D001141:Aromatase / Q000378:metabolism*; D004967:Estrogens / Q000096:biosynthesis*; D006801:Humans; D008297:Male
D004967:Estrogens; D001141:Aromatase