[The relationship between serum uric acid and the prognosis of children admitted to pediatric intensive care unit].
To investigate the relationship between hyperuricemia and the prognosis of acute ill children, we evaluated the usefulness of serum uric acid (SUa) and urinary uric acid concentration on admission as prognostic indices in 94 consecutive children admitted to a pediatric intensive care unit. Patients with hyperuricemia (13.1 +/- 5.6 mg/dl) had a higher mortality (13/26, 50% vs 7/68, 10%, P < 0.001), lower blood pH (7.20 +/- 0.18 vs 7.37 +/- 0.10, p < 0.05), lower systolic blood pressure (85 +/- 24 vs 102 +/- 28 mmHg, p < 0.05) and lower body temperature (36.6 +/- 0.8 vs 37.4 +/- 1.0 degrees C, p < 0.05) than did patients with normouricemia (5.0 +/- 1.5 mg/dl). There are no significant difference in uric acid and sodium excretion between hyperuricemic and normouricemic patients. We concluded that elevated serum uric acid on admission is associated with a higher mortality in pediatric ICU patients, therefore it may be used as an important prognostic index to evaluate patients' outcome in acute ill children. Hyperuricemia should also alert physicians to the possibility of profound cell injury caused by various etiology.
Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Y H
YH
Chen
C L
CL
Wang
A J
AJ
Lee
M L
ML
Chu
D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D011379:Prognosis; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid