Intravenous sodium lactate decreases plasma GABA levels in man.
Gamma aminobutyric acid (GABA), an inhibitory neurotransmitter, may play an important role in anxiety. We studied changes in plasma GABA levels in nine healthy subjects before and after infusions of sodium lactate and dextrose. Plasma GABA significantly decreased during infusions of sodium lactate (109.3 +/- 4.4 versus 91.6 +/- 5.1 pmol/ml; P = 0.0001) but not during infusions of dextrose.
Department of Psychiatry, Wayne State University School of Medicine and Lafayette Clinic, Detroit, MI 48207.
R
R
Balon
F
F
Petty
V K
VK
Yeragani
G L
GL
Kramer
R
R
Pohl
D000328:Adult; D001007:Anxiety / Q000139:chemically induced; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007262:Infusions, Intravenous; D007773:Lactates / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D019344:Lactic Acid; D008297:Male; D005680:gamma-Aminobutyric Acid / Q000097:blood*
D007773:Lactates; D019344:Lactic Acid; D005680:gamma-Aminobutyric Acid; D005947:Glucose