Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia.
Serotonin 5-HT1A and 5-HT2 receptors were examined in the postmortem brains of controls and patients with chronic schizophrenia. In the prefrontal cortex from patients with schizophrenia, 5-HT1A receptor binding was increased, while 5-HT2 receptor binding was decreased, when compared to controls. The increased 5-HT1A receptor binding or the decreased 5-HT2 receptor binding was observed in both the patients who had been medicated with neuroleptics at time of death and those who had not, at least 2 months prior to death. Thus, abnormalities of 5-HT receptor subtypes seem to exist in the brains of patients with chronic schizophrenia. 5-HT related agents might be beneficial for the treatment of schizophrenia.
Hashimoto
T
T
Department of Psychiatry and Neurology, Kobe University School of Medicine, Japan.
Kitamura
N
N
Kajimoto
Y
Y
Shirai
Y
Y
Shirakawa
O
O
Mita
T
T
Nishino
N
N
Tanaka
C
C
D002908:Chronic Disease; D006801:Humans; D011985:Receptors, Serotonin / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*
D011985:Receptors, Serotonin