Bovine spongiform encephalopathy in Germany.
Bovine spongiform encephalopathy (BSE) has been described as an epidemic central nervous disorder in cattle from the United Kingdom. The disease is thought to have emerged by an interspecies transmission of the scrapie agent of sheep to cattle, after feeding scrapie-contaminated meat and bone meal (MBM). The disease has caused substantial economic losses for the British cattle industry. Because of strict veterinary regulations for the import of adult British cattle by the European Union and for MBM by most of the member states the spread of BSE to continental Europe could be efficiently controlled, and only few cases have been described outside the UK. Here we report the first German case of BSE diagnosed in a Scottish Highland cow. The affected cow was imported into Germany before the import ban for cattle from the UK was implemented. BSE was confirmed by histopathology, immunohistochemistry, animal experiments, immunoblotting and by electron microscopic detection of scrapie-associated fibrils (SAFs).
Ludwig-Maximilians-Universität, Institute for Medical Microbiology, Munich, Germany.
O R
OR
Kaaden
U
U
Truyen
M H
MH
Groschup
A
A
Uysal
E
E
Kaiser
H
H
Kretzschmar
T
T
Bogumil
J
J
Pohlenz
H
H
Diringer
P
P
Steinhagen
D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005858:Germany / Q000453:epidemiology; D015151:Immunoblotting; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D018622:PrP 27-30 Protein / Q000032:analysis
D018622:PrP 27-30 Protein