Use of hemoperfusion in experimental intoxication with nerve agents.
The aim of this study was to evaluate the efficiency of hemoperfusion (HP) through coated resin adsorbent Synachrom E-5 in animal intoxications with organophosphate inhibitors of cholinesterases type of nerve agents. Five anesthetized dogs were intoxicated with 2 to 6 LD50 of VX substance and another 4 with 2 to 3 LD50 sarine. Both nerve agents were given i.m. after starting 5 h HP. The clinical and laboratory tests were monitored during each HP. HP therapy prevented the development of serious signs of intoxication provided that the administered quantity of both sarine and the VX substance was only 2 doses of LD50. Specific antidote therapy was necessary to prevent cardiorespiratory failure in animals intoxicated with a higher dose of poison. The results obtained show that HP through Synachrom E-5 in intoxication with nerve agents sarine and the VX type is only partially successful.
Monhart
V
V
Third Department of Internal Medicine, Central Army Hospital, Prague, Czech Republic.
Fusek
J
J
Brndiar
M
M
Tlustakova
M
M
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004285:Dogs; D006464:Hemoperfusion; D008297:Male; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D012524:Sarin / Q000506:poisoning*
D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D012524:Sarin; C009680:VX-agent