Effect of tonsillectomy on peripheral blood T cell surface markers and cytokine production in patients with IgA nephropathy accompanied by chronic tonsillitis.
The present study investigated changes in peripheral blood T cell surface markers and cytokines (interleukin-2, IL-2; tumor necrosis factor-alpha, TNF-alpha; and interferon-gamma, IFN-gamma) following tonsillectomy in patients with IgA nephropathy accompanied by chronic tonsillitis. Peripheral blood CD8+ cells, CD45RA+CD4+ cells and CD8+CD11b- cells increased significantly after tonsillectomy, compared with their preoperative values. In some cases, the preoperative serum TNF-alpha and IFN-gamma levels were higher than normal before surgery, but decreased after surgery. These results suggest that tonsillectomy suppresses a decrease in suppressor T cells in patients with IgA nephropathy and corrects abnormal cell-mediated immune responses in these patients.
2nd Department of Internal Medicine, Nagasaki University, Japan.
Y
Y
Kanamoto
R
R
Shibata
Y
Y
Ozono
T
T
Harada
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis*; D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D014068:Tonsillectomy; D014069:Tonsillitis / Q000150:complications / Q000276:immunology*
D000954:Antigens, Surface; D016207:Cytokines