Abnormalities in adrenal androgens, but not of glucocorticoids, in early Alzheimer's disease.
In an attempt to evaluate possible adrenal abnormalities in Alzheimer's disease (AD), prestimulus levels and ACTH-stimulated serum levels of steroid hormones, corticosteroid-binding globulin (CBG), and insulin-like growth factor I (IGF-I) were measured in 18 patients with early AD (8 men, 10 women; 74.6 +/- 6.5 years, mean +/- SD) and 19 healthy controls (10 men, 9 women; 74.2 +/- 7.6 years, mean +/- SD). Steroid hormone levels were measured before and after an intravenous bolus injection of 250 micrograms ACTH. AD per se had an independent influence on hormone levels when evaluated in MANOVA models. AD patients had significantly higher prestimulus levels of dehydroepiandrosterone and androstenedione (p = .04 and p = .003, respectively) with accentuated differences after ACTH (p = .02 and p < .001 for peak responses, respectively). Serum levels of cortisol, CBG, free cortisol, 17 alpha-hydroxyprogesterone (17 alpha-OHP), and IGF-I did not differ between groups. These abnormalities may have implications for neuronal degeneration as well as for behavioural symptoms in AD.
Näsman
B
B
Department of Geriatric Medicine, University Hospital of Northern Sweden, Umeå.
Olsson
T
T
Seckl
J R
JR
Eriksson
S
S
Viitanen
M
M
Bucht
G
G
Carlstrom
K
K
D000311:Adrenal Glands / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D000728:Androgens / Q000097:blood*; D005260:Female; D005938:Glucocorticoids / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012016:Reference Values; D014156:Transcortin / Q000378:metabolism
D000728:Androgens; D005938:Glucocorticoids; D007334:Insulin-Like Growth Factor I; D000324:Adrenocorticotropic Hormone; D014156:Transcortin