Modulation of cytokine expression by hypericum extract.
The effect of hypericum extract LI 160 on the stimulated cytokine expression was investigated in vitro in a whole blood culture system. Blood samples were taken from five healthy volunteers and four depressive patients. The release of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) was measured quantitatively after an incubation time of 24 hours on microtiter plates. A massive suppression of the interleukin-6 release was found for PHA-stimulated hypericum extract. Possible relations to the antidepressive effects of hypericum extract are discussed.
Thiele
B
B
Medizinische Fakultät (Charité) der Humboldt Universität zu Berlin, Germany.
Brink
I
I
Ploch
M
M
D000928:Antidepressive Agents / Q000494:pharmacology*; D016207:Cytokines / Q000187:drug effects* / Q000378:metabolism; D003863:Depression / Q000276:immunology; D006801:Humans; D020902:Hypericum; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D010569:Perylene / Q000031:analogs & derivatives* / Q000494:pharmacology; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000378:metabolism; D014966:Xanthenes / Q000494:pharmacology*
D000928:Antidepressive Agents; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D014966:Xanthenes; D010569:Perylene; D011794:Quercetin