[The lesion of somatosensory area II of cerebral cortex reducing the effects of electroacupuncture of "zusanli" on nucleus raphe magnus in rats].
This work was to study the influence of lesion of Sm II on effects of electroacupuncture (EA) upon nucleus raphe magnus (NRM). The experiments were performed on rats. The unit discharges of NRM neurons and their responses to noxious stimulation on tail tip were recorded extracellularly with glass microelectrode. The excitatory neurons of NRM were chosen and divided into two groups, one of them (n = 10) was control before lesion of bilateral Sm II and another (n = 17) after lesion, two neurons of this group were also observed before lesion. It was found that the neurons in the control group before lesion of sm II could be activated by EA of "Zusanli", the increase of spontaneous diacharges in 0-10 minutes and the 20th minute, and the decrease of their nociceptive responses in 0-25 minutes were statistically significant (P < 0.05-0.001). But in the group after lesion the neurons were not obviously activated by EA of "Zusanli". The difference of the spontaneous discharges between the two group was statistically significant in 0-10 minutes (P < 0.05-0.001), the nociceptive responses in 0-10 minutes and at the 20th minute (P < 0.05-0.001). The results show that integrity of Sm II is important to acupuncture analgesia, and further suggest that information from EA of "Zusanli" could arrive at Sm II at least partially, and then activate NRM inducing analgesia.
Institute of Acupuncture and Moxibustion, China Academy of T. C. M. Beijing.
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D015667:Acupuncture Analgesia; D015669:Acupuncture Points; D000818:Animals; D015671:Electroacupuncture; D004594:Electrophysiology; D005260:Female; D008297:Male; D009474:Neurons / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D013003:Somatosensory Cortex / Q000502:physiology*