[Changes in the contents of plasma SOD and MDA in 50% III degree burn dogs after delayed fluid replacement].
The plasma SOD and MDA content were determined in 50% III degree burn dogs with delayed fluid replacement. The results showed that the activity of plasma total SOD and CuZn-SOD rapidly declined and were obviously lower during the first 5 days postburn than preburn values, while the content of Mn-SOD did not show significant change. The plasma MDA was evidently elevated in 24 hour but returned to the normal level in 48-72 hours after burn, however it distinctly rose again after 72 hours post-burn. The results suggest that delayed fluid replacement induced generation of free radicals after burn injury, with the result of the occurrence of lipid peroxidation.
Burn Institute, Third Military Medical College, Chongqing.
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Cui
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Z
Yang
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Cheng
D000818:Animals; D002056:Burns / Q000378:metabolism* / Q000628:therapy*; D004285:Dogs; D005440:Fluid Therapy; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors
D008315:Malondialdehyde; D013482:Superoxide Dismutase