Acute 2,4-dichlorophenoxyacetic acid intoxication in cattle.
The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) was studied in cattle. Steers were orally treated with 100, 300 or 600 mg 2,4-D/kg. Behavioral alterations, heart and respiratory functions, rectal temperature and ruminal movements were observed at 2, 4, 8, 12, 24, 48, 72 and 96 h after treatment. At these moments, blood and urine samples were collected and serum 2,4-D levels were determined. Results show that animals' vital function and hematocrit were not modified by the herbicide. Other signs were doses and time-dependent and included motor alterations (weakness, lethargy, decreased general activity) and decreased ruminal movements and proteinuria. The herbicide was rapidly excreted and the intoxication signs were completely reserved. 2,4-D is an herbicide of small toxicological consequences for cattle kept under in natural grazing systems.
Research Center for Veterinary Toxicology (CEPTOX), School of Veterinary Medicine, University of Sao Paulo, Brazil.
C A
CA
Paulino
G H
GH
Oliveira
J
J
Palermo-Neto
D015084:2,4-Dichlorophenoxyacetic Acid / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D006400:Hematocrit / Q000662:veterinary; D008297:Male; D008409:Mastication / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D011507:Proteinuria / Q000139:chemically induced / Q000662:veterinary; D011897:Random Allocation; D012137:Respiratory System / Q000187:drug effects
D015084:2,4-Dichlorophenoxyacetic Acid