[Effect of cystamine on formation and repair of post-irradiation single-strand DNA breaks].
Content of breaks in single-strand DNA, activity of superoxide dismutase and concentration of malonic dialdehyde were studied in blood lymphocytes of irradiation-impaired rats after treatment with cystamine. Cystamine decreased the effects of irradiation as showed all the patterns studied. The protective action exhibited by the drug in radiation shielding of DNA involved both direct and indirect effects.
Vladimirov
V G
VG
Lebedev
S N
SN
Antushevich
A E
AE
D000818:Animals; D003538:Cystamine / Q000494:pharmacology*; D004249:DNA Damage; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000528:radiation effects*; D008214:Lymphocytes / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000235:genetics; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D004277:DNA, Single-Stranded; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D003538:Cystamine
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