Localization of the human HTF4 transcription factors 4 gene (TCF12) to chromosome 15q21.
Identification and localization of genes that encode regulators of transcription could provide landmarks for functional analysis of the human genome. Toward this goal, we examined a panel of somatic cell hybrids and assigned the gene (TCF12) encoding the helix-loop-helix transcription factors 4 (HTF4) to chromosome 15. Fluorescence in situ hybridization further localized TCF12 to chromosome 15q21. Northern analysis revealed that the relative abundance of HTF4 gene transcripts is not constant but varies depending on the human cell-line or tissue examined.
Department of Chemistry, Purdue University, W. Lafayette, IN 47907-1393.
Y
Y
Zhang
W L
WL
Flejter
C L
CL
Barcroft
M
M
Rivière
J
J
Szpirer
C
C
Szpirer
M
M
Bina
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002460:Cell Line; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D051381:Rats; D014157:Transcription Factors / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C489532:Tcf12 protein, mouse; C073366:TCF12 protein, human