Improvement in circulatory and oxygenation status by perflubron emulsion (Oxygent HT) in a canine model of surgical hemodilution.
To examine the effect of a low dose of Oxygent HT on hemodynamics and oxygen transport variables in a canine model of profound surgical hemodilution, two groups of adult anesthetized splenectomized beagles were hemodiluted with Ringer's solution to Hb 7 g/dL. The treated group received 1 mL/kg Oxygent HT (90% w/v perflubron emulsion [perfluorooctyl bromide], Alliance Pharmaceutical Corp.) and both groups (7 controls and 10 treated) were further hemodiluted using 6% hydroxyethyl starch until cardiorespiratory decompensation occurred. Pulmonary artery catheterization data and oxygen transport variables were recorded at Hb decrements of 1 g/dL breathing room air. There was no difference among groups during initial hemodilution. However, in the Oxygent HT group there was a statistically significant improvement in mean arterial pressure, CVP, cardiac output, PvO2, SvO2, DO2, and pulmonary venous admixture shunt during profound hemodilution to Hb levels of 6, 5, and 4 g/dL. A low dose of Oxygent HT offered benefit in improving hemodynamics and oxygen transport parameters even under air breathing conditions in a model of surgical hemodilution. This effect was most apparent at lower levels of Hb.
Cernaianu
A C
AC
Department of Surgery and Medicine, UMDNJ-Robert Wood Johnson Medical School, Camden.
Spence
R K
RK
Vassilidze
T V
TV
Gallueci
J G
JG
Gaprindashvili
T
T
Olah
A
A
Weiss
R L
RL
Cilley
J H
JH
Keipert
P E
PE
Faithfull
N S
NS
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001802:Blood Substitutes / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D004655:Emulsions; D005466:Fluorocarbons / Q000494:pharmacology*; D006438:Hemodilution; D006439:Hemodynamics / Q000187:drug effects*; D006842:Hydrocarbons, Brominated; D010100:Oxygen / Q000097:blood*
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron; D010100:Oxygen