Resuscitative retrograde blood cardioplegia. Are amino acids or continuous warm techniques necessary?
This experiment was designed to determine the relative degree of cardiac functional recovery provided by various forms of resuscitative retrograde blood cardioplegia after global ischemic injury. Twenty-four dogs were subjected to 20 minutes of normothermic global myocardial ischemia followed by 60 minutes of cardioplegic arrest by one of three methods: group 1, standard cold blood cardioplegia with a cold terminal dose (n = 8); group 2, aspartate-glutamate-enhanced blood cardioplegia with warm induction and terminal enhancement (n = 8); and group 3, continuous warm blood cardioplegia (n = 8). Sonomicrometry was used to analyze left ventricular function for maximal elastance and preload recruitable stroke work area. Data were recorded at baseline and after 30 and 60 minutes of unloaded reperfusion. The results showed improved early recovery of preload recruitable stroke work area, but not of maximal elastance, after reperfusion of ischemic hearts with warm resuscitative blood cardioplegic solution enhanced with amino acids. The functional improvement provided by this technique was transient, however, and no significant differences were detectable among the groups after 60 minutes of unloaded reperfusion. Neither amino acid enhancement nor continuous warm cardioplegia offered a significant advantage in functional recovery over the standard method of cold blood cardioplegia reperfusion.
Department of Surgery, New York University Medical Center, N.Y. 10016.
T
T
Asai
E A
EA
Grossi
M
M
LeBoutillier
M A
MA
Parish
F G
FG
Baumann
F C
FC
Spencer
S B
SB
Colvin
A C
AC
Galloway
D000818:Animals; D001224:Aspartic Acid; D001769:Blood; D002314:Cardioplegic Solutions / Q000737:chemistry*; D004285:Dogs; D018698:Glutamic Acid; D006324:Heart Arrest, Induced / Q000379:methods*; D009200:Myocardial Contraction / Q000502:physiology; D017682:Myocardial Stunning / Q000503:physiopathology / Q000517:prevention & control*; D012151:Resuscitation; D013318:Stroke Volume / Q000502:physiology; D013696:Temperature; D016277:Ventricular Function, Left / Q000502:physiology
D002314:Cardioplegic Solutions; D001224:Aspartic Acid; D018698:Glutamic Acid