[Experimental study of the effect of antimicrobial substances on the dissemination of solizyme during its purification].
Microorganisms of different taxonomic groups were isolated from intermediate products of microbial lipase and shown to be able to multiply in them. Therefore, the intermediates forming during solizyme production could be potential nutrient media for growth of the contaminating microflora. The effect of chlorhexidine active against the contaminating microorganisms on the growth of the microbial biomass was studied and it was shown that chlorhexidine could lower the dissemination of the intermediates in production of solizyme. Neomycin added at the stage of the solizyme chemical purification retarded solely the growth of staphylococci contaminating the solizyme intermediate products. The use of antimicrobial agents for the solution of the problem of the solizyme microbial contamination requires the consideration of the contamination level, temperature conditions of the production process and susceptibility of the microflora to the antimicrobial agent used.
Kharlamova
Iu A
IuA
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002710:Chlorhexidine / Q000494:pharmacology; D008049:Lipase / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000494:pharmacology
D000890:Anti-Infective Agents; C081378:solysime; D008049:Lipase; D009355:Neomycin; D002710:Chlorhexidine
Eksperimental'noe izuchenie vliianiia antimikrobnykh veshchestv na obsemenennost' solizima v protsesse ego khimicheskoĭ ochistki.