[Effects of haloperidol therapy on dynamics of serum albumin binding capacity in patients with schizophrenia].
Time course of blood serum albumin binding capacity was studied by the fluorescent method in schizophrenics, including those treated with haloperidol. Effective and total albumin concentrations were measured and binding reserve estimated, which was equal to ratio of effective to total albumin concentrations multiplied by 100%. Effective albumin concentrations and albumin binding reserve were found markedly reduced in the patients vs. healthy donors. Drastic changes of albumin binding reserve from one examination to another and a trend to increase of effective concentration of albumin were characteristic of patients administered haloperidol. In the patients administered no haloperidol albumin binding reserve was as a rule unchanged and effective albumin concentration had a trend to reduction.
Gryzunov
Iu A
IuA
Misionzhnik
E Iu
EIu
Uzbekov
M G
MG
Molodetskikh
A V
AV
D000328:Adult; D005453:Fluorescence; D006220:Haloperidol / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*; D012709:Serum Albumin / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism
D012709:Serum Albumin; D006220:Haloperidol
Vliianie terapii galoperidolom na dinamiku pokazateleĭ sviazyvaiushcheĭ sposobnosti al'bumina syvorotki krovi u bol'nykh shizofrenieĭ.