Analysing the sequence diversity of the 5' NC-region of HCV-isolates found in southern Germany.
In this study we compared the nucleotide sequence of the 5' NC-region of the HCV genome isolated from seven patients and two blood donors from Southern Germany. We could identify two very distinct groups of isolates: the first very similar to the HCV prototype sequence (HCV1) with homology ranging from 99.5% to 98.7%; the second showing 91.7% homology to the HCV1. Group 1 isolates could be found in five patients and the two blood donors. Group 2 isolates could be found in the two other patients. Finally, we could observe neither nucleotide insertion nor deletion in the isolates described here.
Da Silva Cardoso
M
M
German Red Cross Blood Bank Ulm, University of Ulm.
Epple
S
S
Koerner
K
K
Kubanek
B
B
D001483:Base Sequence; D014644:Genetic Variation / Q000235:genetics*; D016679:Genome, Viral; D005838:Genotype; D005858:Germany; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D012367:RNA, Viral