Prevalence of antihuman parvovirus B19 IgG antibodies in patients with refractory rheumatoid arthritis and polyarticular juvenile rheumatoid arthritis.
We investigated the prevalence of antihuman parvovirus B19 immunoglobulin G (IgG) antibody in 108 Japanese patients with rheumatoid arthritis (RA) and 11 patients with polyarticular juvenile rheumatoid arthritis (JRA). Seropositivity of anti-B19 was significantly higher in patients with refractory RA (57.6%, 38/66) compared with patients with remittent RA (19.0%, 8/42; P < 0.001) or age-matched controls (24.3%, 19/78; P < 0.001). Patients with refractory polyarticular JRA had a significantly higher frequency of anti-B19 seropositivity (71.4%, 5/7) than age-matched controls (8.3%, 5/60; P < 0.001), while none of the remittent group was positive for the antibody (0/4).
Department of Medicine, Jichi-Medical School, Tochigi, Japan.
A
A
Mimori
Y
Y
Misaki
T
T
Hachiya
K
K
Ito
S
S
Kano
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D001171:Arthritis, Juvenile / Q000276:immunology* / Q000821:virology; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000821:virology; D016022:Case-Control Studies; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D016732:Parvovirus B19, Human / Q000276:immunology*; D015995:Prevalence; D012075:Remission, Spontaneous; D012698:Serologic Tests
D000914:Antibodies, Viral; D007074:Immunoglobulin G