[LDL apheresis in the treatment of hyperlipoproteinemia].
In order to the reduce the LDL level of Familial hypercholesterolemia (FH), direct LDL removal techniques have been used in several laboratories. In Japan, selective LDL-apheresis by dextran sulfate cellulose column have been developed and is used in treatment of homo- and heterozygous FH patients. In this paper, I reviewed the effectiveness of LDL-apheresis treatment in FH patients with many evidences of regression of atherosclerosis and discussed the potential role of this technique in the future treatment for coronary heart disease. No significant side effect for long term treatment is not experienced.
Kure National Hospital, Department of Internal Medicine.
K
K
Ishikawa
D001161:Arteriosclerosis / Q000628:therapy; D001781:Blood Component Removal / Q000009:adverse effects; D002482:Cellulose; D008078:Cholesterol, LDL / Q000097:blood / Q000302:isolation & purification*; D016264:Dextran Sulfate; D005838:Genotype; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics / Q000628:therapy*
D008078:Cholesterol, LDL; D002482:Cellulose; D016264:Dextran Sulfate