Thalamic stroke: correlation of clinical symptoms, somatosensory evoked potentials, and CT findings.
We studied 18 patients with a single ischemic thalamic lesion, who had somatosensory disturbances and/or central pain in the opposite hemibody, by correlating their clinical symptoms, somatosensory evoked potentials (SEPs), and computed tomography (CT) findings. Patients were divided into three groups: (1) those with somatosensory deficits, central pain, and abnormal SEPs, which comprised two thirds of the patients (classic thalamic pain syndrome), (2) those with somatosensory deficits, no central pain, and abnormal SEPs (analgetic thalamic syndrome), and (3) those with almost normal sense perception, central pain, and normal SEPs (pure algetic thalamic syndrome). CT evidence of a paramedian or anterolateral thalamic lesion might be an indicator for the development of central pain, because these types of infarctions occurred only in patients with the classic thalamic syndrome or the pure algetic thalamic syndrome. The differentiation of the thalamic syndrome into three subtypes is of prognostic value, because patients with a loss of cortical SEPs and a posterolateral ischemic thalamic lesion on the CT scan probably will not exhibit central pain.
Department of Neurology, Medical University of Lübeck, Germany.
K
K
Wessel
P
P
Vieregge
C
C
Kessler
D
D
Kömpf
D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000175:diagnosis / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006429:Hemiplegia / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009619:Nociceptors / Q000503:physiopathology; D010146:Pain / Q000503:physiopathology; D017288:Pain Threshold / Q000502:physiology; D012678:Sensation Disorders / Q000175:diagnosis / Q000503:physiopathology; D013003:Somatosensory Cortex / Q000503:physiopathology; D013786:Thalamic Diseases / Q000175:diagnosis* / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology; D014057:Tomography, X-Ray Computed