The n-3 polyunsaturated fatty acid levels in rat tissue lipids increase in response to dietary olive oil relative to sunflower oil.
In the present study, changes in phospholipid compositions of liver microsomes, erythrocyte membranes, platelets, aorta, cardiac muscle and brain of rats fed olive oil were compared with those of rats fed sunflower oil. Four groups of rats starting at weaning were fed for four weeks a basal diet containing 5 or 25% olive oil or sunflower oil. We found that oleic acid was higher and linoleic acid was lower in membrane phospholipids of olive oil fed rats compared to sunflower oil fed rats. Polyunsaturated fatty acids of the n-3 series were markedly elevated in all tissues of rats on the olive oil diets relative to those on the sunflower oil diets. The results are consistent with a lower linoleic/linolenic acid ratio induced by the olive oil diets, suggesting a positive correlation between olive oil ingestion and n-3 polyunsaturated fatty acid levels in cell and tissue lipids. The study suggests that an adequate intake of olive oil may enhance the conversion of n-3 fatty acids.
Navarro
M D
MD
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Granada, Spain.
Periago
J L
JL
Pita
M L
ML
Hortelano
P
P
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004910:Erythrocyte Membrane / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000032:analysis*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D000069463:Olive Oil; D010743:Phospholipids / Q000378:metabolism*; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil
D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D000069463:Olive Oil; D010743:Phospholipids; D010938:Plant Oils; D000074242:Sunflower Oil