Effects of 5HT3 receptor antagonism by tropisetron on the sleep EEG and on nocturnal hormone secretion.
Two dosages (5 mg and 25 mg) of the selective 5HT3 receptor antagonist tropisetron (ICS 205-930) were administered to healthy male controls, and the effects on the sleep EEG and nocturnal secretory activity of growth hormone (GH) and cortisol were evaluated. The lower dosage was administered to four subjects and the higher dosage to eight on 5 consecutive days, preceded and followed by 2 days of placebo treatment. After 25 mg of tropisetron, there was a slight increase in REM sleep in the first part of the sleep period, and stage 2 was decreased during the total night. In addition, plasma cortisol levels increased earlier than under placebo, and plasma GH levels were reduced in the second part of the night. Thus, only discrete effects of tropisetron upon sleep-endocrine activity were noted, making it unlikely that serotoninergic neurotransmission exerts its well-documented effects upon sleep through 5HT3 receptors.
Rothe
B
B
Max Planck Institute of Psychiatry Clinical Institute, Department of Psychiatry, Munich, Germany.
Guldner
J
J
Hohlfeldt
E
E
Lauer
C J
CJ
Pollmächer
T
T
Holsboer
F
F
Steiger
A
A
D000328:Adult; D004569:Electroencephalography / Q000187:drug effects*; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007211:Indoles / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D000077526:Tropisetron
D006728:Hormones; D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron; D013006:Growth Hormone; D006854:Hydrocortisone