Effect of praziquantel on sex hormone levels in murine schistosomiasis mansoni.
Changes in sex hormonal levels were studied in Schistosoma mansoni infected and praziquantel treated mice (400 x 2 mg/Kg), drug control and in normal control groups. It was observed that schistosomiasis lead to increase in the level of testosterone, progesterone and 17B-esteradiol, 60 and 70 days postinfection in male and female mice, respectively. In praziquantel treated group the level of testosterone was lowered 10, 20 & 30 days post treatment, progesterone and 17 beta-estradiol fell 30 days post treatment after primary rise. The mechanism of recorded changes will be discussed in details.
Department of Parasitology, Benha Faculty of Medicine, Benha Branch of Zagazig University, Egypt.
K F
KF
Abdalla
S M
SM
Abdel-Aziz
A F
AF
el Fakahany
A S
AS
el-Hamshary
L M
LM
Afifi
D000818:Animals; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D010053:Ovary / Q000187:drug effects; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D011374:Progesterone / Q000378:metabolism*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000378:metabolism; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D011223:Praziquantel