Colocalization of prolyl endopeptidase and amyloid beta-peptide in brains of senescence-accelerated mouse.
Prolyl endopeptidase-like immunoreactivity (PEP-LI) was detected and compared with amyloid beta-peptide-like immunoreactivity (A beta-LI) in the brains of senescence-accelerated mouse (SAM). Granular structures of PEP-LI in the hippocampus appeared progressively, and age- and strain-dependently to form deposits which distributed morphologically similar and closely to those of A beta-LI. These results suggest that PEP has functional relevance to amyloidgenesis in brains of SAM.
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Fukuoka, Japan.
A
A
Fukunari
A
A
Kato
Y
Y
Sakai
T
T
Yoshimoto
S
S
Ishiura
K
K
Suzuki
T
T
Nakajima
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry; D006624:Hippocampus / Q000737:chemistry / Q000201:enzymology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000378:metabolism*; D013045:Species Specificity
D016229:Amyloid beta-Peptides; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases