Potential anxiolytic agents. Pyrido[1,2-a]benzimidazoles: a new structural class of ligands for the benzodiazepine binding site on GABA-A receptors.
Maryanoff
B E
BE
Drug Discovery, R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477.
Ho
W
W
McComsey
D F
DF
Reitz
A B
AB
Grous
P P
PP
Nortey
S O
SO
Shank
R P
RP
Dubinsky
B
B
Taylor
R J
RJ
Gardocki
J F
JF
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D001569:Benzodiazepines / Q000378:metabolism*; D001665:Binding Sites; D007700:Kinetics; D051379:Mice; D011725:Pyridines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D011725:Pyridines; D011963:Receptors, GABA-A; D001569:Benzodiazepines