[Beta-interferon treatment of HPV infections of the lower genital tract in women].
In the period 9-1989/12-1991, 47 fertile women affected by genital HPV infection have been treated with i.m. systemic beta-interferon (3 x 10 x 6 UI every other day for 4 weeks). We have noticed 1 case of drop-out (2, 1%). At the short-medium follow-up (> or = 6 months), the therapy has proved to be probably and/or certainly efficacious in 74.4% of cases (35/47). In patients with condylomas in the cervical region, the less respondent part, we have noticed a reaction in 64.3% of cases; in those who have an extra-cervical or diffused HPV infection, in 89.4%. In the patients with complete follow-up, treated with supplementary DTC if necessary, the recovery ratio reached 92.5%. The i.m. systemic therapy with beta-IFN is efficacious in the treatment of genital HPV infections: it is well tolerated and offers the possibility of obtaining a useful "therapeutic integration" with the traditional destructive physical techniques of therapy.
Divisione di Ostetricia e Ginecologia, Regione Lombardia, USSL n. 63-Ospedale di Desio, Milano.
F
F
Bernasconi
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P
Gritti
G
G
Ersettigh
F
F
Galli
S
S
Arienti
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005831:Genital Diseases, Female / Q000628:therapy*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000628:therapy*; D013997:Time Factors; D014412:Tumor Virus Infections / Q000628:therapy*
D016899:Interferon-beta
Trattamento con beta-interferone delle infezioni da HPV del basso tratto genitale femminile.