Stimulation of erythrocyte membrane Mg(2+)-ATPase activity by dinitrophenol and other membrane-disturbing agents.
Erythrocyte membrane Mg(2+)-ATPase activity was stimulated by echinocytogenic agents (2,4-dinitrophenol and salicylate), a stomatocytogenic agent Triton X-100 and other membrane-disturbing agents including hydrophobic organic anions, alcohols and detergents. Various possible mechanisms of the stimulation are possible but apparently most probable one consists in induction of membrane phospholipid scrambling by the compounds studied (as demonstrated for DNP) and of aminophospholipid translocase (flippase) activity.
Bartosz
G
G
Department of Molecular Biophysics, University of Lodz, Poland.
Bartosz
M
M
Sokal
A
A
Gebicki
J M
JM
D019297:2,4-Dinitrophenol; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects; D004140:Dinitrophenols / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D017830:Octoxynol / Q000494:pharmacology
D004140:Dinitrophenols; D017830:Octoxynol; D017301:Ca(2+) Mg(2+)-ATPase; D019297:2,4-Dinitrophenol