Brain aromatase activity and plasma testosterone levels are elevated in aggressive male mice during early ontogeny.
Testosterone (T) and estradiol (E2) are involved in intraspecific aggressive behavior. Both steroids exert their effects on behaviour via the hypothalamus and the amygdala (Am) of the central nervous system (CNS). In these brain areas T is converted to E2, by the enzyme aromatase. Both the levels of brain aromatase activity (AA) and the effects of T and E2 on aggressive behavior in adulthood depend on steroidal organization of the CNS during ontogeny. In this study we measured plasma T and in vitro brain AA of males fetuses and neonates derived from two strains of wild house mice, which had been genetically selected for aggression, based upon attack latency. There were no differences in preoptic area (POA) AA levels between selection lines on either embryonic day (E) 17 or 18, or the day after birth (day 1). In the non-aggressive long attack latency (LAL) males the POA AA increases with age, i.e. was higher on E18 than on E17, which is correlated with brain weight (BrW). This was in contrast to aggressive short attack latency (SAL) fetuses, which only showed a slight, but not significant differences between embryonic days or a correlation with BrW. Neonatally, the POA AA of LAL males tended to decrease in contrast to SAL males. However, SAL neonates had a higher AA in the amygdala (Am) than LAL neonates, whereas no differences exist in the anterior hypothalamus. Thus, a differential brain AA distribution exists in SAL and LAL pups.(ABSTRACT TRUNCATED AT 250 WORDS)
Compaan
J C
JC
University of Groningen, Department of Animal Physiology, Haren, The Netherlands.
Hutchison
J B
JB
Wozniak
A
A
de Ruiter
A J
AJ
Koolhaas
J M
JM
D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001141:Aromatase / Q000378:metabolism*; D001835:Body Weight; D001921:Brain / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D005260:Female; D005333:Fetus; D008297:Male; D051379:Mice; D009929:Organ Size; D011247:Pregnancy; D011301:Preoptic Area / Q000201:enzymology; D011863:Radioimmunoassay; D013045:Species Specificity; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D001141:Aromatase