Effects of acute and chronic ethanol administration on neurotensinergic systems.
A summary of pharmacogenetic studies designed to test the hypothesis that NT receptors might mediate or regulate some of the actions of ethanol is presented. Indeed, there are significant genetic correlations between ethanol-induced locomotor activation and high-affinity NT receptor densities in the FC. The results suggest that further studies are needed to determine the role of NT receptors in the FC and MPFC in regulating locomotor activity. In other studies, chronic ethanol treatment, under conditions that produced tolerance to ethanol and caused NT receptor downregulation in the NA and VMB, caused tolerance to locomotor inhibitory effects of centrally administered NT and blunted the effects of intra-VTA NT on dopamine metabolism in the NA and CP. The results show a relationship between NT receptor densities and pharmacological effects of ethanol.
Alcohol Research Center, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262.
V G
VG
Erwin
B C
BC
Jones
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R
Myers
D000437:Alcoholism / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D002552:Cerebral Ventricles / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D018028:Receptors, Neurotensin / Q000378:metabolism; D011995:Recombination, Genetic; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
D018028:Receptors, Neurotensin; D000431:Ethanol; D004298:Dopamine