Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: in vivo degradation behaviour.
Copolymers of 1,5-dioxepan-2-one (DXO) and L- or D,L-dilactide have been synthesized and characterized. The molar ratio of the two monomers was around 20/80 of DXO and L- or D,L-lactide respectively. In vivo studies on rats revealed significant differences in tissue response between the semicrystalline DXO/L-LA copolymer and the amorphous DXO/D,L-LA copolymer. The materials were characterized pre- and post-implantation by size-exclusion chromatography (SEC), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and light-microscopy. Degradation seems to follow an autocatalytic hydrolysis mechanism. The amorphous copolymer was degraded at a faster rate and gave a less pronounced foreign body reaction as compared to the semicrystalline one.
Löfgren
A
A
Department of Polymer Technology, Royal Institute of Technology, Stockholm, Sweden.
Albertsson
A C
AC
Zhang
Y
Y
Bjursten
L M
LM
D000818:Animals; D001673:Biodegradation, Environmental; D004146:Dioxanes / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000378:metabolism*; D007700:Kinetics; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D004146:Dioxanes; D006571:Heterocyclic Compounds; C091881:1,5-dioxepan-2-one; C091880:dilactide