Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy.
We examined the inferior olivary nucleus from four cases of olivary hypertrophy and six control cases immunohistochemically with an anti-synaptophysin (SYP) antibody. Our study revealed the altered SYP-immunoreactive pattern in the hypertrophied olives, consisting of an increased number of SYP-immunoreactive dots on neuronal cell bodies in spite of its decreased immunoreactivity in the neuropil. Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy.
Department of Pathology, Montefiore Medical Center, New York.
T
T
Kawanami
T
T
Kato
J F
JF
Llena
A
A
Hirano
H
H
Sasaki
D000368:Aged; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009847:Olivary Nucleus / Q000378:metabolism / Q000473:pathology*; D017729:Presynaptic Terminals / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism*
D016708:Synaptophysin