Effects of adrenergic receptor blockers on adrenaline and nicotine-induced hyperglycaemia in the rat.
Studies in fasted, anaesthetized rats have shown that adrenaline and nicotine-induced hyperglycaemia is mediated via activation of beta-adrenoceptors. The hyperglycaemic response to nicotine is different from that of adrenaline in that, unlike adrenaline hyperglycaemia, nicotine hyperglycaemia is characterized by a long latent period, delayed attainment of peak of response and sustained hyperglycaemia throughout the 120 minutes post-injection observation. Comparison with previous studies in dogs showed that different receptors are involved in nicotine hyperglycaemia in fasted dogs and fasted rats.
Oyebola
D D
DD
Department of Physiology, College of Medicine, University of Ibadan, Nigeria.
Alada
A R
AR
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004195:Disease Models, Animal; D004285:Dogs; D004837:Epinephrine; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009538:Nicotine; D011217:Practolol / Q000627:therapeutic use*; D011224:Prazosin / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001786:Blood Glucose; D009538:Nicotine; D011433:Propranolol; D011217:Practolol; D011224:Prazosin; D004837:Epinephrine