Biological models of carcinogenesis and quantitative cancer risk assessment.
Biologically-based models of carcinogenesis were originally developed to explain certain quantitative phenomena associated with carcinogenesis, and to provide a framework within which questions regarding the process could be addressed. Some limitations in the use of these models for quantitative cancer risk assessment are discussed.
Moolgavkar
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SH
D000818:Animals; D002273:Carcinogens; D016022:Case-Control Studies; D015331:Cohort Studies; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D006801:Humans; D015994:Incidence; D016013:Likelihood Functions; D008175:Lung Neoplasms / Q000209:etiology; D008906:Mining; D008954:Models, Biological; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D009784:Occupational Diseases / Q000209:etiology; D011886:Radon / Q000009:adverse effects; D018570:Risk Assessment
D002273:Carcinogens; D011886:Radon