Synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan: a new analogue of heptylphysostigmine (MF 201).
The synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan is described. The compound is structurally related to the cholinesterase inhibitor heptylphysostigmine (MF 201) because the angular methyl group of the esoroline nucleus has been changed into a bridging carbon and the anilinic nitrogen has been replaced by a methylene group. This compound proved to be a potent cholinesterase in vitro inhibitor.
Dipartimento di Scienze Biochimiche, A. Rossi Fanelli, Università La Sapienza, Roma.
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M
Brufani
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L
Filocamo
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E
Imbriani
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S
Lappa
L
L
Mannina
D001575:Benzomorphans / Q000138:chemical synthesis*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010830:Physostigmine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
C091667:2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan; D001575:Benzomorphans; D002800:Cholinesterase Inhibitors; C052450:physostigmine heptyl; D010830:Physostigmine