Deletion 20q in association with Philadelphia chromosome positive acute lymphoblastic leukemia. A report of two cases.
Cytogenetic deletions involving the long arm of chromosome 20 are thought to be characteristic of myeloid disorders. We report clinical and cytogenetic observations of two adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia: one with a smaller 20q deletion that was the sole cytogenetic abnormality in a persisting remission clone, the other with a larger 20q deletion that was a late addition to the leukemic clone at disease relapse following allogeneic bone marrow transplantation.
Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.
P E
PE
Hollings
S M
SM
Benjes
I
I
Rosman
P H
PH
Fitzgerald
D000293:Adolescent; D000328:Adult; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*