Capacity for red blood cell aggregation is higher in athletic mammalian species than in sedentary species.
The purpose of this study was to show that two rheological parameters, red blood cell (RBC) sedimentation rate and apparent blood viscosity at low shear rate, characterizing the degree of RBC aggregation, correlate significantly with the maximal mass-specific rate of oxygen consumption or aerobic capacity (VO2max). Comparisons were made within two groups of similarly sized athletic and sedentary species: group 1, pronghorn antelope, dog, goat, and sheep; and group 2, horse and cow. The pronghorn antelope (Antilocapra americana) is one of the most athletic mammals, and we have obtained data on the rheological properties of blood from this species for the first time. The values of apparent viscosity at hematocrit = 40% and shear rate = 0.277 s-1 measured in a rotational viscometer were 59.5, 42.6, and 9.1 cP for antelope, dog, and sheep blood, respectively, and 55.3 and 11.5 cP for horse and cow blood, respectively. The viscosity values for antelope, dog, and sheep blood can be correlated with aerobic capacity: ln viscosity = 4.48-106.3 VO2(-1)max (r2 = 0.998; P < 0.05). The values of RBC sedimentation rate at hematocrit = 40% were 12.8, 7.0, and 0 mm/h for antelope, dog, and sheep blood, respectively, and 45.3 and 0.1 mm/h for horse and cow blood, respectively. Therefore, the data showed that the athletic species exhibit a consistently higher degree of RBC aggregation than do the corresponding nonathletic species.
Popel
A S
AS
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205.
Johnson
P C
PC
Kameneva
M V
MV
Wild
M A
MA
D000818:Animals; D000866:Antelopes / Q000097:blood* / Q000502:physiology; D001809:Blood Viscosity; D002417:Cattle / Q000097:blood / Q000502:physiology; D004285:Dogs / Q000097:blood* / Q000502:physiology; D004903:Erythrocyte Aggregation / Q000502:physiology*; D006041:Goats / Q000097:blood / Q000502:physiology; D006400:Hematocrit; D006736:Horses / Q000097:blood* / Q000502:physiology; D010101:Oxygen Consumption; D012756:Sheep / Q000097:blood / Q000502:physiology; D013045:Species Specificity