Effects of formulation, processing and storage parameters on the characteristics and stability of perflubron emulsion.
In this study, the effects of formulation, processing and storage parameters on perflubron (perfluorooctyl bromide; PFOB) emulsions were investigated. Emulsions with varying concentrations of perflubron and egg yolk phospholipid (EYP) were prepared with different processing parameters and placed at different storage temperatures. Their characteristics and stability were compared. The emulsion droplet growth rate was nearly proportional to the perflubron percentage in the range of 15-110% w/v. The initial droplet size of perflubron emulsions was inversely proportional to the concentration of EYP until a certain lower limit of droplet size was reached. The initial droplet size and droplet growth rate of perflubron emulsion were strongly dependent upon the processing parameters. The logarithmic value of the droplet growth rate decreased linearly with l/T in the range of 5-40 degrees C. The formulation and processing parameters are the key variables to be optimized to achieve better emulsion characteristics and stability.
Alliance Pharmaceutical Corp., San Diego, California 92121.
Y
Y
Ni
T J
TJ
Pelura
T A
TA
Sklenar
R A
RA
Kinner
D
D
Song
D004355:Drug Stability; D004530:Egg Yolk / Q000737:chemistry; D004655:Emulsions; D005466:Fluorocarbons / Q000737:chemistry*; D006842:Hydrocarbons, Brominated; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry; D013048:Specimen Handling / Q000379:methods*
D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D010743:Phospholipids; C003072:perflubron