Breast feeding in neonatal alloimmune thrombocytopenia.
Infants with neonatal alloimmune thrombocytopenia are at risk of severe intracranial haemorrhage. Placental transfer of maternal immunoglobulin G (IgG) directed against fetal platelet antigens is known to be the underlying mechanism. Since breast milk contains IgG it is theoretically possible that breast feeding of these infants could cause thrombocytopenia. The following case report shows that an infant with neonatal alloimmune thrombocytopenia may be safely breast fed, even when the breast milk contains the platelet specific antibody (HPA-1a).
Department of Paediatrics, Monash Medical Centre, Clayton, Victoria, Australia.
J
J
Reese
T S
TS
Raghuveer
P M
PM
Dennington
C P
CP
Barfield
D016824:Antigens, Human Platelet / Q000276:immunology; D001942:Breast Feeding; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis; D008297:Male; D008895:Milk, Human / Q000276:immunology; D011247:Pregnancy; D013921:Thrombocytopenia / Q000276:immunology
D016824:Antigens, Human Platelet; D007074:Immunoglobulin G; D007518:Isoantibodies