Comparative analysis of HIV-1 and HIV-2 indeterminate western blot patterns.
A comparison of HIV-1 and HIV-2 indeterminate Western blot patterns of Ghanaian sera collected between 1989 and 1990 was made. Antibodies to group specific antigen (GAG) gene products were most frequently detected both HIV-1 and HIV-2 indeterminate sera. HIV-2 GAG gene product p26 was shown to be a non-specific indicator of infection. Antibody to gp120, and envelope gene product of HIV-1 never occurred in indeterminate sera whereas antibodies to all the envelope gene products of HIV-2 were detected in indeterminate sera.
Virology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon.
N K
NK
Ayisi
M
M
Aidoo
D015153:Blotting, Western / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D005869:Ghana / Q000453:epidemiology; D015483:HIV Antibodies / Q000097:blood*; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D006679:HIV Seropositivity / Q000453:epidemiology / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D015498:HIV-2 / Q000276:immunology; D006801:Humans; D011159:Population Surveillance; D016036:Seroepidemiologic Studies
D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120