Astroglial 5-HT1a receptors and S-100 beta in development and plasticity.
The work described in this article is concerned with the role of the 5-HT1a receptor in mediating the neurotrophic effects of serotonin, principally through the release of the substance S-100 beta from astroglial cells. These receptors are also present in astrocytes of the mature brain and may play a role in the synaptic plasticity necessary for certain experience-driven brain changes, such as memory or learning. The presence of these receptors on astroglial cells of the adult brain also has interesting implications for the mechanism of action of many psychotropic drugs acting through the serotonergic system.
Whitaker-Azmitia
P M
PM
Department of Psychiatry, State University of New York, Stony Brook 11794.
Azmitia
E C
EC
D000375:Aging / Q000502:physiology*; D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000502:physiology*; D006801:Humans; D008322:Mammals; D009414:Nerve Growth Factors; D009473:Neuronal Plasticity; D011619:Psychotropic Drugs / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*
D002135:Calcium-Binding Proteins; D009414:Nerve Growth Factors; D011619:Psychotropic Drugs; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D012701:Serotonin