[Usefulness of newly developed 99mTc-labeled STA-R12 for tumor imaging].
We synthesized four new tumor imaging agents, 99mTc-labeled metalloporphyrins (99mTc-STA-R12, -STA-R21, -STA-RN101 and -ATN-12) for the tumor imaging. We compared the differences of tumor imaging potency among these agents in CDF1 mice implanted with colon 26 tumor. Tumor images with these agents were obtained by using digital gamma-camera (RC135-E, Hitachi, Tokyo) and the biodistributions were analyzed by computerized medical radionuclide imageanalyser (RP-200, Hitachi, Tokyo). The highest tumor organ ratio and the excellent tumor image were obtained by 99mTc-STA-R12 (13,17-Bispropanyl aspartic acid-3-ethenyl-8-[N,N',N",N"-tetrakis (carboxylmethyl-2,7,12,18-tetramethyl-porphyrinato]-manga nes e(III). The maximum concentration of 99mTc-STA-R12 in tumor tissue was observed at around 120 minutes after i.v. injection. On the contrary, the uptake rates of other organs and tissues such as liver, brain, muscle, lung, bone and blood continuously decreased. The rapid accumulation of STA-R12 in cancer tissue and the clearance from other tissue suggested a potential usefulness of this compound for tumor imaging agent.
Division of Surgical Operation, Asahikawa Medical College.
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Nakajima
N
N
Shuke
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T
Aburano
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Ishikawa
J
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Sato
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I
Sakata
T
T
Takemura
D000818:Animals; D005069:Evaluation Studies as Topic; D008665:Metalloporphyrins; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013667:Technetium
C091730:13,17-bispropanoylaspartic acid-3-ethenyl-8-((N,N',N'', N'''-tetrakis(carboxylmethyl)diethylenetriaminoacetyloxy)methyl-2,7,12,18-tetramethylporphyrinato)manganese(III); D008665:Metalloporphyrins; D013667:Technetium