Periodontal manifestation of hypophosphatasia. A family case report.
Hypophosphatasia is a rare inherited disease, the 1st clinical sign of which is often a premature loss of deciduous teeth. We describe clinical, histological and SEM findings of 2 cases of hypophosphatasia from a single family and discuss the pathological mechanisms with reference to the literature.
Sektion Parodontologie, Klinik für Zahnerhaltungskunde und Parodontologie im Zentrum für Zahn-, Mund- und Kieferheilkunde, Kiel, Germany.
H C
HC
Plagmann
T
T
Kocher
N
N
Kuhrau
A
A
Caliebe
D000469:Alkaline Phosphatase / Q000097:blood; D016301:Alveolar Bone Loss / Q000209:etiology; D002675:Child, Preschool; D003739:Dental Cementum / Q000473:pathology; D003782:Dental Pulp / Q000473:pathology; D005260:Female; D006801:Humans; D007014:Hypophosphatasia / Q000235:genetics* / Q000473:pathology; D007223:Infant; D008297:Male; D010510:Periodontal Diseases / Q000209:etiology*; D010513:Periodontal Ligament / Q000473:pathology; D012391:Root Resorption / Q000209:etiology / Q000473:pathology; D014080:Tooth Exfoliation / Q000209:etiology* / Q000473:pathology; D014094:Tooth, Deciduous / Q000473:pathology
D000469:Alkaline Phosphatase