Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.
Infection of cattle with the protozoan parasite Theileria parva results in a fatal lymphoproliferative syndrome that is associated with the overexpression of casein kinase II. The role of this enzyme in the pathogenesis of lymphoproliferative disorders was investigated by expressing the catalytic subunit in lymphocytes of transgenic mice. Adult transgenic mice displayed a stochastic propensity to develop lymphoma; co-expression of a c-myc transgene in addition to casein kinase II resulted in neonatal leukemia. Thus, the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c-myc.
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115.
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D047390:Casein Kinase II; D002417:Cattle; D002471:Cell Transformation, Neoplastic; D003001:Cloning, Molecular; D015971:Gene Expression Regulation, Enzymologic; D015329:Gene Rearrangement, T-Lymphocyte; D016259:Genes, myc; D007938:Leukemia / Q000209:etiology; D008214:Lymphocytes / Q000201:enzymology; D008223:Lymphoma / Q000201:enzymology / Q000209:etiology* / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D013801:Theileriasis / Q000201:enzymology*; D015854:Up-Regulation
D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases