Aerobic-anaerobic gene regulation in Escherichia coli: control by the ArcAB and Fnr regulons.
A variety of pathways for carbon and electron flow in the bacterium Escherichia coli and in other enteric bacteria are differentially expressed depending on whether molecular oxygen is present in the cell environment. This review briefly summarizes the metabolic pathways operative during aerobic versus anaerobic cell growth, and provides a regulatory overview for how the cell controls expression of the many genes involved in these processes. The cell has two distinctly different transcriptional regulators, consisting of the Fnr and the ArcA/ArcB regulatory proteins to accomplish this task. Together, they coordinate gene expression to adjust carbon flow with electron flow and energy generation so that cells can balance growth in an efficiently coupled manner.
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024.
R P
RP
Gunsalus
S J
SJ
Park
D000332:Aerobiosis / Q000235:genetics*; D000693:Anaerobiosis / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029968:Escherichia coli Proteins; D066298:In Vitro Techniques; D007506:Iron-Sulfur Proteins; D008565:Membrane Proteins / Q000235:genetics*; D011494:Protein Kinases; D018085:Regulon / Q000235:genetics; D012097:Repressor Proteins
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C060704:FNR protein, E coli; D007506:Iron-Sulfur Proteins; D008565:Membrane Proteins; D012097:Repressor Proteins; C041610:arcA protein, E coli; D011494:Protein Kinases; C065271:arcB protein, E coli