Effect of occupational exposure to aldrin on urinary D-glucaric acid, plasma dieldrin, and lymphocyte sister chromatid exchange.
The effects of exposure to the chlorinated cyclodiene termiticide aldrin was evaluated in pest control workers potentially exposed to this material. Sister chromatid exchange (SCE) frequencies were not elevated in workers handling aldrin. This is consistent with the fact that chlorinated cyclodienes are not genotoxic. Plasma dieldrin concentrations (up to 250 ng/ml) confirmed exposure in workers actively performing termiticide treatments and in maintenance and store workers, when compared with unexposed control workers (median concentration, 4.8 ng/ml). Urinary D-glucaric acid (DGA), an index of hepatic enzyme activity, was elevated in pesticide-exposed groups but urinary DGA was poorly correlated with plasma dieldrin level. This indicates that concurrent exposures of these groups to other pesticides may have influenced mixed-function oxidase metabolic activity.
Department of Clinical and Experimental Pharmacology, University of Adelaide, South Australia.
J W
JW
Edwards
B G
BG
Priestly
D000293:Adolescent; D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced / Q000175:diagnosis*; D000452:Aldrin / Q000009:adverse effects*; D003367:Cotinine / Q000652:urine; D003404:Creatinine / Q000652:urine; D004026:Dieldrin / Q000097:blood*; D005260:Female; D005937:Glucaric Acid / Q000652:urine*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis; D010571:Pest Control; D012854:Sister Chromatid Exchange
D003404:Creatinine; D004026:Dieldrin; D003367:Cotinine; D000452:Aldrin; D005937:Glucaric Acid