Structure and chromosomal localization of the human PD-1 gene (PDCD1).
A cDNA encoding mouse PD-1, a member of the immunoglobulin superfamily was previously isolated from apoptosis-induced cells by subtractive hybridization. To determine the structure and chromosomal location of the human PD-1 gene, we screened a human T cell cDNA library by mouse PD-1 probe and isolated a cDNA coding for the human PD-1 protein. The deduced amino acid sequence of human PD-1 was 60% identical to the mouse counterpart, and a putative tyrosine kinase-association motif was well conserved. The human PD-1 gene was mapped to 2q37.3 by chromosomal in situ hybridization.
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.
T
T
Shinohara
M
M
Taniwaki
Y
Y
Ishida
M
M
Kawaichi
T
T
Honjo
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D002460:Cell Line; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D051379:Mice / Q000235:genetics; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D061026:Programmed Cell Death 1 Receptor; D011506:Proteins; D012333:RNA, Messenger / Q000302:isolation & purification; D017386:Sequence Homology, Amino Acid
D015703:Antigens, CD; D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D007136:Immunoglobulins; D009363:Neoplasm Proteins; C105992:PDCD1 protein, human; C491383:Pdcd1 protein, mouse; D061026:Programmed Cell Death 1 Receptor; D011506:Proteins; D012333:RNA, Messenger