Pharmacokinetic profile of conjugated verrucarol urinary metabolites in dogs.
The pharmacokinetics and renal excretion of a trichothecene mycotoxin, verrucarol, were studied in six mongrel dogs following IV administration (0.4 mg kg-1). The fraction of verrucarol excreted intact in the urine ranged from 0.9% to 2.7% of the administered dose. The fraction of verrucarol metabolites excreted in the urine was 32-60% for verrucaryl glucuronides and 32-47% for verrucaryl sulphates. These urinary conjugated metabolites were analysed quantitatively following their enzymatic hydrolysis. The half-life of verrucarol calculated from the urinary data of its conjugated metabolites was not significantly different from the half-life calculated from the plasma data of the parent compound.
Barel
S
S
Department of Pharmacy, School of Pharmacy, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Yagen
B
B
Bialer
M
M
D000818:Animals; D004285:Dogs; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005965:Glucuronates / Q000652:urine; D006207:Half-Life; D006868:Hydrolysis; D008297:Male; D013431:Sulfates / Q000652:urine; D014255:Trichothecenes / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
D005965:Glucuronates; D013431:Sulfates; D014255:Trichothecenes; C011140:verrucarol