[Effects of Chinese herb decoction sizunzituang on metabolism and nutrition in burnt guinea pigs].
Sizunzituang is a decoction prepared by boiling water extraction of codonopsis pilosulae, Acractylodes, poria and glycyrrhiza. Male burnt (30% TBSA) guinea pigs weighing 380-420 grams with a pre-formed gastrostomy were studied. The animals were divided into two groups, both of them were fed with pellet chow. One received sizunzituang, while the other group served as controls. The treated group was found to eat more food, with better nitrogen balance, higher body and ileum mucosal weights, and higher nitrogen contents of the liver and ileum mucosa than control group. However, the body and carcase weights as well as gastrocnemius muscle nitrogen contents in the treated group were reduced significantly as compared with those in the control group. In addition, Sizunzituang can also regulate the secretion of hormones and visceral water contents. The above findings indicate that the decoction may be beneficial in improving the metabolism, nutrition, and visceral organ functions after a burn injury.
Burns Research Unit Southwestern Hospital, Third Military Medical University, Chongqing.
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Ruan
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Wang
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Li
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002056:Burns / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D011897:Random Allocation
D004365:Drugs, Chinese Herbal