[Soluble interleukin-2 receptor level in the sera and ascitic fluids in patients with ovarian cancer].
In 31 patients with ovarian cancer, the sIL-2R level of the sera and ascitic fluids were measured by ELISA, to investigate the inhibitive effect of sIL-2R purified from ascitic fluids on normal lymphocyte transformation, stimulated with phytohemagglutinin (PHA). The results showed that the sera sIL-2R levels in the patients were much higher than those in the normal controls (857 +/- 428kU/L vs 235 +/- 90kU/L, P < 0.001). The sera sIL-2R levels in mucinous cancer were significantly higher than those in serous cancer (988 +/- 539kU/L vs 488 +/- 233kU/L P < 0.01). But no obvious correlation was observed with the histopathological grading, nor with metastasis. Higher levels of sIL-2R were also observed in the ascitic. The normal lymphocyte transformation stimulated with PHA was significantly inhibited by high sIL-2R purified from the ascitic fluids.
Pu
F R
FR
Third Teaching Hospital, Bethune University of Medical Sciences, Changchun.
Cheng
S W
SW
Zhu
D
D
D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000737:chemistry; D018282:Cystadenocarcinoma, Mucinous / Q000276:immunology*; D018283:Cystadenocarcinoma, Papillary / Q000276:immunology*; D005260:Female; D006801:Humans; D007725:Krukenberg Tumor / Q000276:immunology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D015375:Receptors, Interleukin-2