[Differences in the cellular response of the immune system in patients with Paget's disease of bone after elcatonin and etidronate administration].
A cellular immunological defect is present in patients with Paget's disease of the bone. Low counts of CD4, high counts of CD8, and a low CD4/CD8 ratio were observed in 58 patients compared with controls. These findings were not correlated with the metabolic activity of the disease. After therapy with Elcatonine an improvement in the cellular immunological defect was observed in 15 patients. Etidronate improved the biochemical bone patterns but no changes were observed in the number of lymphocytic subpopulations. These changes can be related to the improvement in the bone metabolic disorder or be the result of an effect on the altered immunity in this disease.
Servicio de Medicina Interna (Unidad Metabólica), Fundación Jiménez Díaz y Universidad Autonoma, Madrid.
A
A
Rapado
E
E
López Gavilanes
P
P
Palomino
M
M
Yagüe
C
C
de la Piedra
M
M
Díaz Curiel
F
F
Ortiz
D000368:Aged; D015415:Biomarkers / Q000032:analysis; D016723:Bone Remodeling / Q000187:drug effects; D016516:CD4-CD8 Ratio / Q000187:drug effects; D002116:Calcitonin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004341:Drug Evaluation; D012968:Etidronic Acid / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism
D015415:Biomarkers; D002116:Calcitonin; D012968:Etidronic Acid; C012755:elcatonin
Diferencias en la respuesta celular del sistema inmune en pacientes con la enfermedad ósea de Paget tras la administración de elcatonina y etidronato.