An immunocytochemical study on the distribution of calcitonin gene-related peptidergic nerve fibers in rat nasal mucosa.
The distribution of calcitonin gene-related peptidergic (CGRP) nerve endings in rat nasal mucosa was investigated with immunocytochemical technique (ABC method). The results showed that CGRP endings had a robust localization along the walls of arterioles, venules and around the acini of glands, with the endings near the wall of arterioles being most strongly stained. The typical morphology of CGRP endings could be recognized as multistage-branched terminals with rosary varicosities. CGRP immunoreactive neurons were also found in the trigeminal ganglion (TG). Supported by morphological evidence, we suggest that CGRP endings in rat nasal mucosa are the peripheral fibers originating from the ganglion cells in TG. These fibers may be involved in the perception of mucosal stimuli and the propagation of nerve impulse to the central terminals and will thus release CGRP in the brain stem. There is also possibility that CGRP may be peripherally released following local stimulation in the nasal mucosa and exert influences on the mucosal functions.
Department of Otolaryngology, Xiangya Hospital, Hunan Medical University, Changsha.
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Tao
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009297:Nasal Mucosa / Q000737:chemistry* / Q000294:innervation*; D009411:Nerve Endings; D009474:Neurons / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D015740:Calcitonin Gene-Related Peptide