Azole resistance in oropharyngeal Candida albicans strains isolated from patients infected with human immunodeficiency virus.
For 212 oropharyngeal isolates of Candida albicans, the fluconazole MICs for 50 and 90% of strains tested were 0.5 and 16 micrograms/ml, respectively, and those of itraconazole were 0.05 and 0.2 micrograms/ml, respectively. Of 16 isolates for which fluconazole MICs were > 64 micrograms/ml, itraconazole MICs for 14 were < or = 0.8 micrograms/ml and for 2 were > 6.4 micrograms/ml. Most fluconazole-resistant strains remained susceptible to itraconazole; whether itraconazole will prove effective for refractory thrush remains to be shown.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor.
X
X
He
R N
RN
Tiballi
L T
LT
Zarins
S F
SF
Bradley
J A
JA
Sangeorzan
C A
CA
Kauffman
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D002176:Candida albicans / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009960:Oropharynx / Q000382:microbiology*
D017964:Itraconazole; D015725:Fluconazole