The effect of maternal oxygen administration during the second stage of labor on umbilical cord blood gas values: a randomized controlled prospective trial.
OBJECTIVE
Our aim was to determine whether supplemental oxygen during the second stage of normal labor affects cord blood gas and cooximetry values.


METHODS
Patients at term pregnancy were prospectively randomized to the control or treatment group at the onset of the second stage of labor. The treatment group received 10 L/min oxygen by face mask, which result in a mean fractional inspired oxygen concentration of 0.81.


RESULTS
There were 86 patients randomized into the study. In the oxygen group there were significantly more cord arterial pH values < 7.20 (9/41 vs 2/44, p < 0.05). The control group was compared with two subgroups of patients receiving oxygen: those receiving oxygen therapy for < or = 10 minutes and those receiving oxygen for > 10 minutes. Analysis of variance demonstrated significant differences (7.285 +/- 0.058, 7.312 +/- 0.056, 7.237 +/- 0.064; F test 8.3, p = 0.0005). Among several independent variables, regression analysis demonstrated that only duration of oxygen therapy had a significant inverse relation to cord arterial pH (F test = 15.6, p = 0.0002).


CONCLUSIONS
Prolonged oxygen treatment during the second stage of normal labor resulted in a deterioration of cord blood gas values at birth.
Department of Obstetrics and Gynecology, Saint Luke's Hospital of Kansas City, MO 64111.
J A
JA
Thorp
T
T
Trobough
R
R
Evans
J
J
Hedrick
J D
JD
Yeast
D000328:Adult; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn / Q000097:blood*; D007748:Labor Stage, Second; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D011247:Pregnancy; D011446:Prospective Studies
D001639:Bicarbonates; D002245:Carbon Dioxide; D010100:Oxygen