[The effect of chemical mutagens on mammalian spermatogenesis. A quantitative evaluation].
A quantitative analysis of spermatogenesis in mice and rats has shown that the response of various germ cells to cytotoxic effects of Dipin or NMU differs. The spermatogonial compartment consisting of actively proliferating cells and some stem cells are the main targets for these drugs. The advanced I order spermatocytes, spermatids and spermatozoa proved to be less susceptible. Species specific differences have been established in the character of destructive and restorative processes during spermatogenesis.
S T
ST
Zakhidov
L P
LP
Paraniushkina
H H
HH
Mahran
E S
ES
Abdel-Hadi
V A
VA
Golichenko
D000818:Animals; D001388:Aziridines / Q000494:pharmacology / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009153:Mutagens / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
D001388:Aziridines; D009153:Mutagens; D008770:Methylnitrosourea; C007526:dipin
Vliianie khimicheskikh mutagenov na spermatogenez mlekopitaiushchikh. Kolichestvennaia otsenka.