In vitro and in vivo effect of the nootropic agent adafenoxate on the 5-HT1 sites in different rat brain structures.
1. The effect of the nootropic agent adafenoxate (a structural analogue of meclofenoxate) on the binding parameters of 5-HT1 receptors in vitro and in vivo in rat cerebral cortex, striatum, hippocampus and hypothalamus was studied. 2. The chronic (100 mg/kg per os for 7 days) adafenoxate treatment produced a significant (24.6%) decrease in the density of 5-HT1 sites in the hippocampus. 3. In vitro adafenoxate inhibited specific [3H]5-HT binding with equal potency in all the regions studied with IC50s in the microM range. 4. It is suggested that the decrease in the density of the 5-HT1 sites in rat hippocampus might contribute to the nootropic action of adafenoxate.
Department of Pharmacology, Bulgarian Academy of Sciences, Sofia.
C I
CI
Hadjiivanova
S L
SL
Stancheva
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D002504:Meclofenoxate / Q000031:analogs & derivatives* / Q000494:pharmacology; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000032:analysis / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism
D018697:Nootropic Agents; D011985:Receptors, Serotonin; D012701:Serotonin; C054061:adafenoxate; D002504:Meclofenoxate