Nonsteroidal antiinflammatory drug-induced colonic stricture. An unusual cause of large bowel obstruction and perforation.
Nonsteroidal antiinflammatory drugs (NSAIDs) are widely prescribed drugs that can result in gastroduodenal ulceration. Adverse effects upon the small and large intestine are now more often recognized. Small intestinal obstruction secondary to both mucosal diaphragms and broad-based stenoses is reported, but colonic strictures appear to be less common. A case of NSAID-induced colonic stricture leading to large bowel obstruction and secondary cecal perforation (previously unreported) is presented. Twelve additional cases of NSAID-induced colonic stricture are reviewed from the literature and its possible pathogenesis is discussed.
Department of Surgery, University Hospital, Nottingham, U.K.
M H
MH
Robinson
T
T
Wheatley
I H
IH
Leach
D000082:Acetaminophen / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D003106:Colon / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D003108:Colonic Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D003692:Delayed-Action Preparations; D011431:Dextropropoxyphene / Q000009:adverse effects; D004008:Diclofenac / Q000009:adverse effects; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004630:Emergencies; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D011899:Ranitidine / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004008:Diclofenac; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; D011899:Ranitidine; D001241:Aspirin; D011431:Dextropropoxyphene