[Role of synovial inflammation, cytokines and IGF-1 in the physiopathology of osteoarthritis].
The role of cytokines in the progression of arthritic diseases such as osteoarthritis (OA) has received particular attention because of the important interaction between articular cartilage and synovium in the pathology of the diseased state. Chondrocytes and synovial cells are targeted by cytokines such as interleukin 1 (IL-1) and tumor necrosis factor (TNF-alpha) to produce matrix proteases and to suppress the synthesis of collagen and proteoglycan. Thus, cytokines not only favor tissue destruction, but also inhibit tissue repair. Furthermore, growth factors such as insulin-like growth factor (IGF-1), may not be able to counteract the effect of cytokines on the synthesis of matrix components or natural inhibitors of cartilage degrading enzymes due to a resistance of the chondrocyte to the action of this hormone. This article discusses the action of cytokines and growth factor IGF-1 and their relationship to the pathophysiology of OA.
Rheumatic Disease Unit, Notre-Dame Hospital, Montréal, Québec, Canada.
J P
JP
Pelletier
J
J
Martel-Pelletier
D002358:Cartilage, Articular / Q000378:metabolism; D016207:Cytokines / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D010003:Osteoarthritis / Q000503:physiopathology*; D013585:Synovitis / Q000503:physiopathology*
D016207:Cytokines; D016326:Extracellular Matrix Proteins; D007334:Insulin-Like Growth Factor I
Rôle de l'inflammation synoviale, des cytokines et de l'IGF-1 dans la physiopathologie de l'arthrose.