[Kaposi's disease in a female patient with acquired HIV-negative immunodeficiency].
A 79-year-old woman of Mediterranean ascent suffered from corticosteroid-dependent chronic obstructive lung disease, hypogammaglobulinemia (IgG 1 and 2), decreased CD16 natural killer cell function and non-HIV related CD4 and CD8 lymphopenia. Such immunodeficiency could be either a variant of common variable immunodeficiency or an early stage of the idiopathic CD4 + T lymphocytopenia syndrome. She developed bilateral lesions of Kaposi's sarcoma on the lower extremities resembling the classic European type of the disease. The tumors contained both CD34 + and Factor XIIIa + cells. The HLA-DR5 haplotype was not found. Weekly low intravenous dosages of vinblastine improved the lesions but the patient died from pontic infarction.
Service de Dermatopathologie, CHU du Sart Tilman, Liège, Belgique.
A F
AF
Nikkels
J
J
Collignon
M P
MP
Moutschen
P
P
Paquet
C
C
Bouillenne
G E
GE
Piérard
D000368:Aged; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology; D008775:Methylprednisolone / Q000009:adverse effects*; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000276:immunology
D008775:Methylprednisolone
Maladie de Kaposi chez une patiente souffrant d'une immunodéficience acquise VIH négative.