Platelet adenylate cyclase activity in Israeli victims of Iraqi Scud missile attacks with post-traumatic stress disorder.
Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-stimulated, PGE1-stimulated or forskolin-stimulated activity between controls and PTSD subjects. Epinephrine inhibition of forskolin-stimulated activity, an effect mediated by alpha 2 adrenergic receptors, was slightly but not significantly increased in the PTSD patients compared to the controls, while 5-HT induced inhibition, an effect mediated by putative 5-HT1a-like receptors, was unchanged. The relationship of these activities to measures of anxiety and depression in these patients is discussed.
Weizmann
R
R
Tel Aviv Community Mental Health Center, Tel Aviv, Israel.
Gur
E
E
Laor
N
N
Reiss
A
A
Muller
U
U
Yoresh
A
A
Lerer
B
B
Newman
M E
ME
D000262:Adenylyl Cyclases / Q000097:blood*; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology; D005576:Colforsin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007493:Iraq; D007557:Israel; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012969:Sodium Fluoride / Q000494:pharmacology; D013268:Stimulation, Chemical; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000201:enzymology*; D014857:Warfare
D005576:Colforsin; D012969:Sodium Fluoride; D000262:Adenylyl Cyclases; D004837:Epinephrine