[Disulone hypersensitivity syndrome].
Hypersensitivity to dapsone (Disulone) is a rare side effect of sulfone therapy. The diagnosis is based on variable clinical manifestations and laboratory findings dominated by hyperthermia, skin eruptions and a mixed form of hepatitis. We observed a case of hypersensitivity to dapsone in a 57-year-old woman who was treated with Disulone for cicatricaial pemphigoid. Clinical manifestations and laboratory results returned to normal 3 weeks after drug withdrawal. This case is interesting because the skin eruptions classically described were not observed. In addition this is apparently the first case reported of such a hypersensitivity syndrome occurring during treatment of autoimmune bullous dermatosis.
Service de Dermato-Vénéréologie, CHRU Dupuytren, Limoges.
L
L
Risse
P
P
Bernard
A
A
Brosset
V
V
Enginger
C
C
Bedane
J M
JM
Bonnetblanc
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003622:Dapsone / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D010390:Pemphigoid, Benign Mucous Membrane / Q000188:drug therapy*; D013577:Syndrome
D003622:Dapsone
Syndrome d'hypersensibilité a la Disulone.