Serum electrolyte and protein changes after intravenous injection of sodium and meglumine diatrizoate (urograffin-370).
Serum electrolyte and protein changes in 35 Nigerian patients undergoing intravenous urography were evaluated after injection of 60 mls sodium and meglumine diatrizoate (Urograffin-370). Statistically, significant changes were noted in the values of serum calcium, proteins and albumin at 5 and 30 minutes after the injection (P < 0.005). The mean percentage decreases noted were calcium 13%, protein 17% and albumin 13%. At 30 minutes post-injection, the serum protein and albumin levels had incompletely recovered while calcium values continued to decrease. Non-statistically, significant changes were observed in the values of serum sodium, potassium and phosphate at 5 and 30 minutes respectively following contrast medium injection. Alterations in the levels of serum electrolytes especially calcium are most probably responsible for such adverse effects as convulsions and cardiac arrhythmias.
Nzeh
D A
DA
Department of Radiology, University of Ilorin, Nigeria.
Erasmus
R T
RT
Aiyedun
B A
BA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D004573:Electrolytes / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D012709:Serum Albumin / Q000187:drug effects; D012964:Sodium / Q000097:blood
D001798:Blood Proteins; D004573:Electrolytes; D010710:Phosphates; D012709:Serum Albumin; D003974:Diatrizoate Meglumine; D012964:Sodium; D011188:Potassium; D002118:Calcium