Spurious fibrinogen levels secondary to pyroglobulinemia in Waldenström's macroglobulinemia.
We report two cases of pyroglobulinemia detected in the course of routine determination of fibrinogen levels measured by the heat-precipitation method and that led to the diagnosis of Waldenström's macroglobulinemia. The incidence of pyroglobulinemia is briefly discussed, and the potential significance of this laboratory artifact is emphasized.
Department of Medicine, Mount Sinai School of Medicine, New York, New York.
P J
PJ
Cagnoni
R
R
Lenzi
N
N
Wisch
S
S
Seremetis
J H
JH
Rand
D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000473:pathology; D011232:Chemical Precipitation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood / Q000652:urine; D008875:Middle Aged; D011750:Pyroglobulins / Q000378:metabolism*; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D011750:Pyroglobulins; D005340:Fibrinogen