Combined testosterone treatment in pubertal and adult periods induces male-specific acetohexamide reductase activity in liver microsomes of female rats.
The influence of testosterone treatment on acetohexamide reductase activities in liver microsomes and cytosol of female rats was examined. Acetohexamide reductase activity in liver microsomes was much lower in female rats than in male rats. Combined testosterone treatment in pubertal and adult periods induced male-specific acetohexamide reductase activity in liver microsomes of female rats. However, testosterone treatment only during puberty or during adulthood was without effect. Testosterone secreted from the testes during puberty appeared to have a significant effect similar to neonatal imprinting in the induction of acetohexamide reductase activity in liver microsomes of female rats. The combined testosterone treatment, or testosterone treatment only during puberty or during adulthood had no effect on acetohexamide reductase activity in liver cytosol of female rats.
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Y
Y
Imamura
Y
Y
Honda
Y
Y
Kozono
A
A
Ryu
M
M
Otagiri
D000375:Aging / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004789:Enzyme Activation; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D000429:Alcohol Oxidoreductases; C064152:acetohexamide reductase