The endocrine outcome after surgical removal of craniopharyngiomas.
The postoperative course of children undergoing surgery for craniopharyngioma was reviewed. Typically they were below height at presentation. All had an attempt at radical surgical resection of the tumor. Most developed diabetes insipidus in the postoperative period, which was permanent in all but 1 child. 94% required thyroid replacement therapy, and sex steroids were administered in 100% when they reached the age of puberty. 91% required maintenance corticosteroids. 54% required growth hormone replacement, but some children showed continued growth despite apparent growth hormone deficiency. Postoperative obesity develops in one half of patients, and may be improved with administration of growth hormone; a controlled trial is underway.
Division of Endocrinology, Hospital for Sick Children, Toronto, Ont., Canada.
J
J
Curtis
D
D
Daneman
H J
HJ
Hoffman
R M
RM
Ehrlich
D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003397:Craniopharyngioma / Q000097:blood / Q000601:surgery*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000008:administration & dosage / Q000172:deficiency; D006801:Humans; D007016:Hypophysectomy; D007018:Hypopituitarism / Q000097:blood / Q000188:drug therapy*; D007223:Infant; D008297:Male; D010901:Pituitary Function Tests; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000097:blood / Q000601:surgery*; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy*; D013974:Thyroxine / Q000008:administration & dosage / Q000097:blood
D010907:Pituitary Hormones; D013006:Growth Hormone; D003894:Deamino Arginine Vasopressin; D013974:Thyroxine