Flow cytometric analysis of uterine sarcomas.
Eighty-four women with sarcoma uteri were evaluated on the basis of histopathological examination findings. In 45 of the 84 cases, a flow cytometric measure of DNA content and S-phase fraction was performed. Thirty-seven cases of the 45 were available for estimation of S-phase fraction. The histopathologic examination of paraffin-embedded tumor tissue revealed 44% leiomyosarcomas, 25% homologous mixed mullerian tumors, 17% endometrial stromacell sarcomas, 7% heterologous mixed müllerian tumors, 1% rhabdomyosarcomas, and 6% unclassified sarcomas. Eighty-six percent of the tumors were aneuploid, 14% were peridiploid, and the 5-year survivals were 20 and 60%, respectively. Clinical stage and lymphocytic reaction were found to be good prognostic parameters. Multivariate analysis of 5-year survival adjusted for age at menopause, clinical stage, mitotic frequency, lymphocytic response, and S-phase fraction did not give any further significant prognostic factors.
Department of Gynecological Oncology, University Hospital, Umeå, Sweden.
K
K
Lennart
B
B
Lennart
S
S
Ulf
T
T
Bernard
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002454:Cell Differentiation; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016196:S Phase; D012509:Sarcoma / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*
D004273:DNA, Neoplasm