Carba analogues of triglycerides--isosteric mimics for natural lipids. Novel substrates for the determination of regio- and enantioselectivities displayed by lipases.
The novel carba analogues 1a,b and 2 were synthesized and demonstrated to be isosteric identical mimics for natural triglycerides. They can be used for the system independent determination of regio- and enantioselectivities displayed by lipases. They are, moreover, attractive starting materials for novel carba analogues of phospholipids, PAF analogues and PAF antagonists.
Bergische Universität-GH-Wuppertal, Germany.
M
M
Berger
B
B
Jakob
M P
MP
Schneider
D000818:Animals; D001419:Bacteria / Q000201:enzymology; D005658:Fungi / Q000201:enzymology; D007202:Indicators and Reagents; D008049:Lipase / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D010179:Pancreas / Q000201:enzymology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013552:Swine; D014280:Triglycerides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*
D007202:Indicators and Reagents; D014280:Triglycerides; D008049:Lipase