Regulation of sex-hormone-binding globulin production by endogenous estrogens in vitro.
The effect of endogenous estrogens on sex-hormone-binding globulin (SHBG) production was studied in HepG2 cells. 17 beta-estradiol, estrone, and estrogens from both 2- and 16 alpha-hydroxylative pathways stimulated SHBG production, but not in parallel with their binding affinities for the estrogen receptor. Thus, the underlying mechanism may be other than a pure interaction with the estrogen receptor.
Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland.
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Loukovaara
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Carson
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Adlercreutz
D000077584:2-Methoxyestradiol; D006528:Carcinoma, Hepatocellular; D004958:Estradiol / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology*; D004970:Estrone / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D006894:Hydroxyestrones / Q000494:pharmacology; D008113:Liver Neoplasms; D012333:RNA, Messenger / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000096:biosynthesis* / Q000235:genetics; D014407:Tumor Cells, Cultured
D004967:Estrogens; D006894:Hydroxyestrones; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D012738:Sex Hormone-Binding Globulin; C026702:16-hydroxyestrone; D004970:Estrone; D004958:Estradiol; D000077584:2-Methoxyestradiol; C001390:2-hydroxyestradiol; D004964:Estriol