[A comparative study of homoharringtonine with 5-fluorouracil in filtering surgery].
With a prospective, randomized and double-masked control method, homoharringtonine(H.H) and 5-Fluorouracil (5-FU) were used in filtering surgery. We compared the effect and side effect of H.H with those of 5-FU. 24 eyes were in H.H group and 23 eyes in 5-FU group. An average follow-up of 18 months revealed: (1) the cumulative percentage of functioning bleb in H.H group (84.9%) was significantly higher than that in 5-FU group (62.2%) (P < 0.05); (2) the cumulative surgical success rate in H.H group (85.7%) was significantly higher than that in 5-FU group (61.1%) (P < 0.05); (3) the rate of corneal erosion in H.H group (20.8%) was significantly lower than that in 5-FU group (52.2%) (P < 0.05), the difference of other complications between H.H group and 5-FU group was not significant.
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
K
K
Yu
D
D
Peng
X
X
Liu
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D005901:Glaucoma / Q000601:surgery*; D006248:Harringtonines / Q000009:adverse effects / Q000627:therapeutic use*; D000077863:Homoharringtonine; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012590:Sclera / Q000601:surgery; D014130:Trabeculectomy
D006248:Harringtonines; D000077863:Homoharringtonine; D005472:Fluorouracil