[Diabetic glomerulosclerosis--a prolonged stage of diabetic glomerulopathy].
Formation of diabetic glomerulosclerosis was followed by the electron microscopy of 21 puncture renal biopsy and 12 incisive pancreatic biopsies from patients with insulin-dependent diabetes mellitus. The influence of the B-cell destruction and the decrease or absence of their activity (the presence of serum C-peptide) on the degree of renal damage and clinical symptoms of the diabetic nephropathy (proteinuria, hypertension) is noted. Dynamics of the diabetic glomerulosclerosis formation is as follows: 1st group--thickening of capillary basal membrane in the glomeruli, mesangial ectopy, formation of nodules at the periphery of loops; 2nd group--increase of the mesangial matrix, doubling of the glomerular capillary basal membrane, hyalin droplets in the capsule membrane. 4 stages in the development of diabetic glomerulopathy are distinguished: diabetic segmentary mesangioproliferative glomerulonephritis, mesangiolysis, two stages of glomerulosclerosis progression. Duration of the disease more than 15 years predetermines the development of diabetic glomerulosclerosis.
Severgina
E S
ES
Ponomarev
A B
AB
Diuzheva
T G
TG
Shestakova
M V
MV
Maĭorova
E M
EM
D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology* / Q000503:physiopathology; D008297:Male
Diabeticheskiĭ glomeruloskleroz--prolongirovannaia stadiia diabeticheskoĭ glomerulopatii.