Protein kinase C inhibitors: novel spirosesquiterpene aldehydes from a marine sponge Aka (= Siphonodictyon) coralliphagum.
Two novel spirosesquiterpene aldehydes, corallidictyals A [1] and B [2], were isolated as a mixture from the marine sponge Aka (= Siphonodictyon) coralliphagum, and their structures were determined by detailed spectroscopic methods. These compounds were identified in a screen for inhibitors of protein kinase C.
Chan
J A
JA
Research and Development, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
Freyer
A J
AJ
Carté
B K
BK
Hemling
M E
ME
Hofmann
G A
GA
Mattern
M R
MR
Mentzer
M A
MA
Westley
J W
JW
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002522:Chlorocebus aethiops; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011161:Porifera; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013141:Spiro Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014709:Vero Cells
D011994:Recombinant Proteins; D012717:Sesquiterpenes; D013141:Spiro Compounds; C091979:corallidictyal A; D011493:Protein Kinase C