Sequence conservation of the major outer capsid glycoprotein of human group C rotaviruses.
Several outbreaks of Group C rotavirus infection have occurred in the United Kingdom, in one instance infection was associated with the death of a 4-month-old infant in the Bristol area. The origin of human group C rotavirus is unknown although there has been some speculation that porcine species may be a possible source of human infection. Direct reverse transcription-polymerase chain reaction sequencing of VP7 genes from two UK outbreaks (Bristol and Preston) and sequence analysis from a sporadic case of infection from Brazil (Belém) showed that each of these genes was identical in size (1,063 bp) and has revealed a surprising level (97.8-99.8%) of gene sequence conservation. Sequence comparisons with an isolate from Japan imply that the human group C rotaviruses so far characterised originate from a recent common ancestor with a worldwide distribution.
Department of Molecular Microbiology, University Medical School, Southampton General Hospital, United Kingdom.
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Grice
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Lambden
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Caul
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Clarke
D000595:Amino Acid Sequence; D000956:Antigens, Viral; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D017124:Conserved Sequence; D017931:DNA Primers / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D004196:Disease Outbreaks; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D005814:Genes, Viral; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D006113:United Kingdom / Q000453:epidemiology
D000956:Antigens, Viral; D036022:Capsid Proteins; D017931:DNA Primers; D018076:DNA, Complementary; D004279:DNA, Viral; C050779:VP7 protein, Rotavirus