Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach progressing to overt B cell malignancy.
A 70 year old man, who underwent subtotal gastrectomy under the diagnosis of reactive lymphoid hyperplasia 6 years earlier, suffered from diffuse large-cell-type B cell lymphoma in the remnant stomach. Retrospectively reviewed, the initial lesion was consistent with mucosa-associated lymphoid tissue (MALT) lymphoma, a low-grade B cell malignancy, based upon histologic, cytologic and immunohistochemical features. Both the initial and recurrent tumors revealed the phenotypes of mantle zone cells, DBA44-positive. It is noteworthy that the overt lymphoma cells retained the capacity for inducing germinal center-like nodules consisting of LN1 and DNA7-positive cells even in the invading site. The diagnosis of reactive lymphoid hyperplasia of the stomach should be made after careful exclusion of the possibility of MALT lymphoma.
Umemura
S
S
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Tang
X
X
Aihara
H
H
Tsutsumi
Y
Y
D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology*