No evidence of linkage or allelic association of schizophrenia with DNA markers at pericentric region of chromosome 9.
Based on our previous study suggesting the pericentric region of chromosome 9 as of potential importance in schizophrenia, we have carried out a linkage study between the schizophrenia phenotype and the dinucleotide repeat polymorphisms D9S55, D9S15, and D9S202 in three pedigrees multiply affected with schizophrenia. In addition, we have conducted allelic association studies using 60 patients with schizophrenia and 60 controls with polymorphisms at D9S55 and D9S15 markers. No evidence for linkage or association was found. The results indicate that susceptibility genes for schizophrenia are less likely to be located at the pericentric region of chromosome 9, assuming genetic homogeneity of the pedigrees.
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
S
S
Nanko
R
R
Fukuda
M
M
Hattori
T
T
Sasaki
X Y
XY
Dai
M
M
Gill
S
S
Kuwata
Y
Y
Shibata
H
H
Kazamatsuri
D000483:Alleles; D002899:Chromosomes, Human, Pair 9; D004247:DNA / Q000032:analysis; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers; D004247:DNA