[Insulin receptors and mechanism of action of insulin and of insulin-like growth factors].
A novel mechanism of activation of the insulin and IGF-I receptors by their respective ligands is proposed, whereby the bivalent ligand bridges the two receptor alpha subunits at opposite sites in a symmetrical receptor structure. The proposed mechanism accounts for the binding stoichiometry and the phenomenon of negative cooperativity. It may play an important role in the regulation of mitogenesis.
De Meyts
P
P
Unité de Biochimie, département de Chimie de l'Université catholique de Louvain.
D006801:Humans; D007328:Insulin / Q000493:pharmacokinetics / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000493:pharmacokinetics / Q000494:pharmacology*; D008024:Ligands; D011485:Protein Binding; D011972:Receptor, Insulin / Q000187:drug effects* / Q000378:metabolism
D007328:Insulin; D008024:Ligands; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin
Récepteurs et mécanismes d'action de l'insuline et des facteurs de croissance insulino-semblables.