Benzyl-benzoate foam: effects on mite allergens in mattress, serum and nasal secretory IgE to Dermatophagoides pteronyssinus, and bronchial hyperreactivity in children with allergic asthma.
Home mattresses of 24 asthmatic children with house dust mite allergy were sprayed with either benzyl-benzoate foam or placebo in a double blind fashion, 10 days before the children left the residential house for asthmatic children Istituto Pio XII (located in the Italian Alps in an environment free of mites) and went back to their own home for the Christmas and Easter holidays. A further group of 8 children, whose mattresses received no treatment, was kept as an absolute control. Two days after spraying, benzyl-benzoate or placebo were vacuumed from the mattresses. Acarex test was performed immediately before spraying and at the end of each holiday period of 20 and 10 days, respectively. Bronchial hyperreactivity as well as serum and nasal secretory specific IgE for Dermatophagoides pteronyssinus were assessed in all children immediately before leaving and within 48 hr after returning to the residential house. The results of the study show that sprayed benzyl-benzoate foam was no more effective than placebo in reducing the level of house dust mite recovered from patients' mattresses, or in reducing bronchial hyperreactivity and IgE concentration in serum and nasal secretions.
Pediatric Department, University of Verona, Italy.
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D000293:Adolescent; D000485:Allergens / Q000009:adverse effects / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D001513:Beds; D001565:Benzoates / Q000008:administration & dosage / Q000494:pharmacology*; D016535:Bronchial Hyperreactivity / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D002648:Child; D004311:Double-Blind Method; D004391:Dust / Q000009:adverse effects / Q000032:analysis; D005260:Female; D006798:Housing; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008925:Mites / Q000187:drug effects* / Q000276:immunology; D009297:Nasal Mucosa / Q000378:metabolism; D012129:Respiratory Function Tests; D013997:Time Factors
D000485:Allergens; D001565:Benzoates; D004391:Dust; D007306:Insecticides; D007073:Immunoglobulin E; C006723:benzyl benzoate