Preclinical testing of iopromide. 2nd communication: toxicological evaluation.
Toxicological characteristics of the non-ionic monomeric X-ray contrast agent iopromide (Ultravist, CAS 73334-07-3) were evaluated in rats, rabbits, guinea-pigs and dogs. The scope of investigations included acute toxicity studies, systemic tolerance investigations with repeated applications, reproduction toxicity studies, examinations on the genotoxic and contact-sensitizing potential and local tolerance studies. Iopromide could be shown to be well tolerated in all the tests and species.
Research Laboratories, Schering Aktiengesellschaft, Berlin, Fed. Rep. of Germany.
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D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D004285:Dogs; D004342:Drug Hypersensitivity / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects
D003287:Contrast Media; D007472:Iohexol; C038192:iopromide