Effect of water temperature on diuresis-natriuresis: AVP, ANP, and urodilatin during immersion in men.
Effects of water temperature on diuresis, natriuresis, and associated endocrine responses during head-out immersion were studied in eight men (23.4 +/- 0.3 yr) during four 5-h experimental conditions: air control at 28 degrees C and immersion at 34.5 degrees C [thermoneutral (Tnt)], 36 degrees C [above Tnt (aTnt)], and 32 degrees C [below Tnt (bTnt)]. Esophageal temperature decreased by approximately 0.4 degrees C in bTnt and increased by approximately 0.5 degrees C in aTnt. Cardiac output increased by approximately 80% in aTnt and approximately 40% in bTnt while thoracic impedance, an index of central blood pooling, decreased by 7.5 omega in bTnt (NS vs. Tnt) and 8.8 omega in aTnt (P < 0.05 vs. Tnt and bTnt). Total peripheral resistance decreased at all temperatures (50% in aTnt, 20% in bTnt). Urine flow and Na+ excretion increased by sixfold in bTnt and Tnt but by only threefold in aTnt. Creatinine clearance was unchanged while osmolal clearance (but not free water clearance) increased two-fold with all immersions. Plasma atrial natriuretic peptide (ANP), urinary urodilatin, and urinary guanosine 3',5'-cyclic monophosphate increased while plasma renin activity, aldosterone, and arginine vasopressin (AVP) decreased similarly at all temperatures. bTnt did not potentiate diuresis by selective attenuation of AVP. The overall natriuretic response exhibited a higher correlation with urodilatin (r = 0.45, P < 0.001) than with ANP (r = 0.26, P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
S
S
Nakamitsu
S
S
Sagawa
K
K
Miki
F
F
Wada
K
K
Nagaya
L C
LC
Keil
C
C
Drummer
R
R
Gerzer
J E
JE
Greenleaf
S K
SK
Hong
D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000652:urine*; D001831:Body Temperature; D004231:Diuresis / Q000502:physiology*; D004562:Electrocardiography; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007101:Immersion; D008297:Male; D009318:Natriuresis / Q000502:physiology*; D009638:Norepinephrine / Q000097:blood; D010446:Peptide Fragments / Q000652:urine*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood; D013696:Temperature; D014867:Water
D010446:Peptide Fragments; D014867:Water; D001127:Arginine Vasopressin; C056452:Ularitide; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin; D009638:Norepinephrine