[The new epidemiologic situation in the Czech Republic caused by the C:2a:P1.2 (P1.5) strain of meningococci].
A new epidemiological situation for invasive meningococcal disease developed in the Czech Republic in 1993. The investigation of meningococcal noncapsular antigens revealed that the new strain Neisseria meningitidis C:2a:P1.2 (P1.5) is the causative agent. This strain has never been found in the Czech Republic before, at least not since 1973 (Czech meningococci have been sero/subtyped since). The investigation of the relationships by ET-typing revealed that this Neisseria meningitidis C:2a:P1.2 (P1.5) belongs to the ET-37 clone. In spring 1993 this new meningococcal clone caused an unusual increase of morbidity in two districts in one region of the Czech Republic and during the next winter/spring season (1993/1994) it spread to all regions of the country. This new strain causes severe and frequently atypical clinical manifestations, with the highest morbidity and fatality rates in the age group of 15-19 years (20% fatality in 1993).
Krízová
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Národní referencní laborator pro meningokokové nákazy, Státní zdravotní ústav, Praha.
Musílek
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Lebedová
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D018153:Czech Republic / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000145:classification*
Nová epidemiologická situace v Ceské republice způsobená meningokokem C:2a:P1.2 (P1.5).