[Tumor infiltrating lymphocytes inhibit spontaneous lung metastasis of LA795 adenocarcinoma in mice].
Tumor Infiltrating Lymphocytes (TILs) isolated from LA795 lung adenocarcinoma in mice have a remarkable antitumor activity, by using T739 syngeneic mice. TILs cytolytic activity in vitro is higher than that of LAK cells. TILs significantly inhibit spontaneous lung metastasis in vivo. The results in experiment I showed the following: TILs injection in tail vein, the inhibitory rate is 73.3%; TILs injection at tumor, 79.9%. The results in experiment II are similar to these in experiment I, and TILs antitumor activity in vivo is as three times as that of LAK cells.
Shen
Y Q
YQ
Beijing Tuberculosis and Thoracic Tumor Research Institute.
Lai
B T
BT
Wang
H
H
D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy*; D000818:Animals; D005260:Female; D016219:Immunotherapy, Adoptive; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation