Are neuropsychiatric manifestations of folate, cobalamin and pyridoxine deficiency mediated through imbalances in excitatory sulfur amino acids?
Folate, cobalamin and pyridoxine deficiency are associated with psychiatric or neurological symptomatology. Disturbances in sulfur amino acid metabolism leading to accumulation of homocysteine occurs in all three conditions as the metabolism of homocysteine depends on enzymes requiring these vitamins as cofactors. Oxidation products of homocysteine (homocysteine sulfinic acid and homocysteic acid) and cysteine (cysteine sulfinic acid and cysteic acid) are excitatory sulfur amino acids and may act as excitatory neurotransmitters, whereas taurine and hypotaurine (decarboxylation products of cysteic acid and cysteine sulfinic acid) may act as inhibitory transmitters. Homocysteic acid and cysteine sulfinic acid have been considered as endogenous ligands for the N-methyl-D-aspartate (NMDA) type of glutamate receptors. The profile of these sulfur amino acid neurotransmitters could be altered in a similar fashion in states of decreased availability of folate, cobalamin or pyridoxine. It is proposed that the mechanism of neuropsychiatric manifestations in all three conditions result from a combination of two insults to homocysteine catabolism in the brain.
Department of Medicine, University of Colorado Health Sciences Center, Denver.
C R
CR
Santhosh-Kumar
K L
KL
Hassell
J C
JC
Deutsch
J F
JF
Kolhouse
D000603:Amino Acids, Sulfur / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000209:etiology*; D018846:Excitatory Amino Acids / Q000378:metabolism*; D005494:Folic Acid Deficiency / Q000150:complications*; D006801:Humans; D001523:Mental Disorders / Q000209:etiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D014806:Vitamin B 12 Deficiency / Q000150:complications*; D026681:Vitamin B 6 Deficiency / Q000150:complications*
D000603:Amino Acids, Sulfur; D018846:Excitatory Amino Acids; D016194:Receptors, N-Methyl-D-Aspartate