[The use of methotrexate in cortico-resistant asthma].
Methotrexate represents a new therapeutic modality in patients with corticoresistant asthma. Its mechanism of action is the competitive inhibition of the folate reducing enzyme, converting folic acid in tetrahydrofolate during the S phase of the cell cycle. It is 50% fixed to albumin and excreted by glomerular filtration and proximal tubule secretion.
Servicio de alergia pediátrica, Instituto Nacional de Pediatría, México, DF.
I
I
Ortíz Aldana
L
L
Arreguín Osuna
R
R
Cariño Javier
E
E
Isart Fagundo
A
A
Meza Morales
D000305:Adrenal Cortex Hormones; D001249:Asthma / Q000188:drug therapy*; D004351:Drug Resistance; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D008727:Methotrexate
Uso de methotrexate en el asma corticorresistente.