Cyanide poisoning in animals and humans: a review.
Cyanide (CN) is a deadly poison which animals and humans encounter from a number of sources. The following article briefly reviews many of the major studies of CN toxicology in animals and humans. The discussion focuses on sources, body levels, metabolic changes, physiopathology, experimental antidotal studies and the diagnosis and management of CN poisoning in humans.
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201.
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Salkowski
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Penney
D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002395:Catecholamines / Q000097:blood; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects; D003486:Cyanides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D004285:Dogs; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced; D008297:Male; D051379:Mice; D011041:Poisoning / Q000209:etiology / Q000628:therapy; D051381:Rats
D000931:Antidotes; D002395:Catecholamines; D003486:Cyanides; D003576:Electron Transport Complex IV