[A comparative evaluation of the toxic and cumulative properties of the Takal drug group].
The acute oral and dermal toxicity was studied as well as subacute oral toxicity [30 successive days] and skin irritating effect on experimental animals of new drug form "Takal 9", "Takal 14" and "Takal 16" with proved bactericidal and virucidal activity. A complex of toxicometric, unspecific, haematological, biochemical and histological studies were performed. The compositions "Takal 9", "Takal 14" and "Takal 16" are slightly toxic at oral and dermal application. LD50 for "Takal 9" and "Takal 16" is above 15,000 mg/kg-1 while for preparation "Takal 14" is not reached. At unrepeated dermal application LD50 for the examined group of preparations surpasses 5000 mg/kg-1. The products have no skin-irritative effect. No cumulative effect is established in the conditions of a 30-day oral treatment. On the background of no changes in the serum indices an activation of the aerobic and anaerobic oxidation in the liver is registered in animals treated with ethyl alcohol, "Takal 9" and "Takal 16". These deviations are due, most probably, to the participation of ethyl alcohol as solvent, in "Takal 9" and "Takal 16". On the basis of the experiments, as most suitable for use, is established the preparation "Takal 14".
Mikhaĭlova
A
A
Khalkova
Zh
Zh
Antov
G
G
Zaĭkov
Kh
Kh
Shumkov
N
N
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D000998:Antiviral Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D001769:Blood / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects
D000890:Anti-Infective Agents; D000998:Antiviral Agents
Sravnitelna otsenka na toksichnite i kumulativnite svoĭstva na lekarstvenata grupa "Takali".