[Effect of ucrinol on lipid metabolism in liver tissue].
Alterations in content of phospholipids as well as dynamics of lipid free-radical oxidation were studied in the hepatocytes of the rats poisoned with various doses of the toxic agent ucrinol within 1.3 and 6 months. Low concentrations of the toxin (1.5 mg/kg) did not cause any detectable alterations of the patterns studied. However, higher concentrations of ucrinol (15-150 mg/kg) produced markedly pronounced destructions which were dose- and time-dependent.
Karagezian
K G
KG
Ovsepian
L M
LM
Adonts
K G
KG
Pogosian
A Iu
AIu
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005609:Free Radicals; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008899:Mineral Oil / Q000633:toxicity*; D010084:Oxidation-Reduction; D051381:Rats
D005609:Free Radicals; C059084:Ukrinol-1; D008899:Mineral Oil
Vliianie ukrinola na lipidnyĭ metabolizm v tkani pecheni.