[Levels of gastrin and somatostatin in blood and gastroduodenal gastrin and somatostatin cells in the differentiation of treatment of patients with duodenal ulcer].
Radioimmunoassay and immunomorphological methods were used in the study of pepsinogen 1, basal and food-stimulated gastrin and somatostatin blood levels, the number of gastroduodenal G- and D-cells as well as gastric secretion during routine-dose treatment with gastrozepin and ranisan of 45 gastroduodenal ulcer patients versus 15 controls. The patients were divided into 2 types according to blood gastrin levels and the number of pyloric G-cells: with hypergastrinemia and/or hyperplasia of the G-cells, with normogastrinemia and normal number of G-cells. A course treatment with gastrozepin of type 1 patients brought about normalization of serum gastrin and the number of the G-cells with elevation of blood somatostatin levels. In patients of type 2 the above parameters did not change. The same picture in them remained after ranisan treatment, though they developed hypergastrinemia. In patients of type 1 after ranisan treatment the above parameters did not change. The data obtained demonstrate once more heterogeneity of duodenal ulcer.
Zverkov
I V
IV
Minushkin
O N
ON
Sokolov
L K
LK
Maslovskiĭ
L V
LV
D000328:Adult; D004381:Duodenal Ulcer / Q000097:blood / Q000188:drug therapy*; D004386:Duodenum / Q000166:cytology*; D005500:Follow-Up Studies; D005755:Gastrins / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D006801:Humans; D008297:Male; D010890:Pirenzepine / Q000627:therapeutic use*; D011899:Ranitidine / Q000627:therapeutic use*; D013004:Somatostatin / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D013270:Stomach / Q000166:cytology*; D013997:Time Factors
D005755:Gastrins; D010890:Pirenzepine; D013004:Somatostatin; D011899:Ranitidine
Urovni gastrina i somatostatina v krovi, gastroduodenal'nye gastrinovye i somatostatinovye kletki pri differentsirovannom lechenii bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki.