The identification of a Caenorhabditis elegans homolog of p34cdc2 kinase.
We have identified a Caenorhabditis elegans homolog of p34cdc2 kinase. The C. elegans homolog, ncc-1, is approximately 60% identical to p34cdc2 of Homo sapiens. When expressed from a constitutive yeast promoter, ncc-1 is capable of complementing a conditional lethal mutation in the CDC28 gene of Saccharomyces cerevisiae, indicating that this C. elegans homolog can properly regulate the cell cycle.
Mori
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Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125.
Palmer
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Sternberg
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016203:CDC2 Protein Kinase / Q000235:genetics*; D017173:Caenorhabditis elegans / Q000201:enzymology*; D002453:Cell Cycle; D003001:Cloning, Molecular; D017238:Genes, Helminth; D005816:Genetic Complementation Test; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D016203:CDC2 Protein Kinase