[Effect of cetirizine therapy on the rate of adverse reactions to specific desensitization].
An effect of cetirizine--one of antihistaminic agents--on the rate of adverse reactions to the specific desensitization has been evaluated in patients with atopic respiratory diseases. The study included 270 patients desensitized in 1988-1993 for the atopic diseases due to hypersensitivity to grass pollens and Dermatophagoides pteronyssinus. Standard Alvac-P. Pollinex, and Alvac-S HDM vaccines have been used. Occurrence and severity of the adverse reactions noted during 3,368 injections of vaccines have been analysed. Frequency and adverse reactions severity have been compared for two periods--1988-1990 when patients have not been given antihistaminic agent, and 1991-1993--when ceterizine has been administered during the whole period of desensitization. It has been found that simultaneous cetirizine administration decreases frequency and severity of adverse reaction to the used vaccines. Such a procedure may be recommended to patients with advance hypersensitivity given vaccines in out-patient clinics.
Kliniki Chorób Zakaźnych Instytutu Medycyny Wewnetrznej Centralnego Szpitala Klinicznego WAM, Warszawie.
J
J
Kruszewski
E
E
Zaraś
D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control; D017332:Cetirizine / Q000627:therapeutic use*; D002648:Child; D003888:Desensitization, Immunologic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000517:prevention & control; D008297:Male; D012130:Respiratory Hypersensitivity / Q000276:immunology* / Q000628:therapy*
D017332:Cetirizine
Wpływ podawania cetirizyny na wystepowanie objawów niepozadanych odczulania swoistego.