Clinical and immunological markers in Kenyan pulmonary tuberculosis patients with and without HIV-1.
Amongst newly diagnosed pulmonary tuberculosis patients, 44% were co-infected with human immunodeficiency virus (HIV). Pulmonary tuberculosis patients with HIV-1 presented more frequently with lymphadenopathy and diarrhoea than those without HIV-1. Peripheral blood CD4+ counts were significantly lower in patients with pulmonary tuberculosis with HIV-1 than those with pulmonary tuberculosis alone, P = 0.0292. CD4+ lymphocyte counts, lymphadenopathy and BCG scar could serve as indicators of HIV-1 infection in pulmonary tuberculosis (PTB) patients.
Diseases Research Unit, Kenya Medical Research Institute, Nairobi.
L E
LE
Kivihya-Ndugga
J J
JJ
Ochola
G
G
Otieno
L N
LN
Muthami
S
S
Gathua
D017088:AIDS-Related Opportunistic Infections / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D000328:Adult; D001500:BCG Vaccine; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D015897:Comorbidity; D005260:Female; D018023:HIV Seronegativity; D015497:HIV-1; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000453:epidemiology / Q000276:immunology
D001500:BCG Vaccine; D015415:Biomarkers