[Experimental study of myocardium protection with warm blood cardioplegia].
The present paper has shown the effects of myocardial protection of isolated rat heart which were infused with different kinds of cardioplegia, and made to be arrested in the state of ischemia and absence of oxygen for 120 min. The heart rate, left ventricular constraction pressure and cardiac output volume, the myocardium water content and calcium content and pathological examination of myocardium were observed. The isolated rabbit heart under the circumstances of ischemia and absence of oxygen at 37 degrees C for 20 min Observations of the different kinds of cardioplegia. was observed that the different pH and oxygen content between artery and vein of the heart during the infusion of cardioplegia, the value of left ventricular constraction pressure multiplied by heart rates after reperfusion with autologous artery blood for 20 min. The values of CPK and MDA in right atrial blood, the ATP and CP volume of myocardium and pathologic study of myocardium were carried out. The results demonstrated that the warm blood cardioplegia had a better myocardial protection effect in supplying sufficient oxygen to myocardium during heart arrest, preserving and increasing energy store; controlling reperfusion in jury after ischemia, buffering acidosis and preserving heart status function. Therefore it has great value for improving the safety of the patients with complex and high risk heart diseases in perioperation.
General Hospital of Shenyang Army of People's Liberation Army.
R W
RW
Chen
Z W
ZW
Wang
F X
FX
Xu
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002314:Cardioplegic Solutions / Q000627:therapeutic use*; D005260:Female; D006324:Heart Arrest, Induced; D066298:In Vitro Techniques; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D002314:Cardioplegic Solutions; D000255:Adenosine Triphosphate; D002118:Calcium