Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity.
We report a case of a 69-year-old woman with an 11-year history of progressive dementia, who was found at autopsy to have classic Pick's disease pathology, as well as extensive paired helical filament -- immunoreactive neurities, with few Alzheimer's disease (AD)-like neurofibrillary tangles and no senile plaques. Both Pick bodies and neuritic degeneration were extensive in the neocortex and hippocampal complex. In addition, synaptophysin immunostaining of the hippocampal complex showed a bilaminar pattern of immunoreactivity in the outer molecular layer as previously described in AD.
Rush Alzheimer's Disease Center, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
E J
EJ
Cochran
J H
JH
Fox
E J
EJ
Mufson
D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D003704:Dementia / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016501:Neurites / Q000473:pathology*; D016708:Synaptophysin / Q000032:analysis*
D016708:Synaptophysin