Drug-related pathological lesions of the intestinal tract.
Pathologists need to be more aware of the capacity of drugs, in particular non-steroidal anti-inflammatory agents, to produce a wide spectrum of lesions in the intestinal tract. Whilst the histological changes brought about by drugs are generally non-specific in character, certain features such as tissue eosinophilia, the presence of apoptotic bodies in the crypts of Leiberkhun or an increase in intra-epithelial lymphocytes in the colon should always raise the suspicion of drug effects.
Pathology Department, Glasgow Royal Infirmary, UK.
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Lee
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003092:Colitis / Q000139:chemically induced / Q000473:pathology; D004751:Enteritis / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D007415:Intestinal Obstruction / Q000139:chemically induced / Q000473:pathology; D007420:Intestine, Large / Q000187:drug effects / Q000473:pathology*; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology*; D014456:Ulcer / Q000139:chemically induced / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal