Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.
Alzheimer's disease results in the appearance of cytoskeletal disorders yielding pathological structures such a neurofibrillary tangles or dystrophic neurites. It has been previously described that the microtubule-associated protein, tau, modified by phosphorylation in serines adjacent to prolines, is a major component of these structures. Here, we show that another microtubule associated protein, MAP1B, aberrantly phosphorylated by a proline-dependent protein kinase, is a component of these previously mentioned structures. Thus, a possible common phosphorylation of axonal MAPs such as tau or MAP1B may correlate with their association with those aberrant cytoskeletal structures present in AD.
Ulloa
L
L
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Fac. de Ciencias, Univ. Autónoma de Madrid, Spain.
Montejo de Garcini
E
E
Gómez-Ramos
P
P
Morán
M A
MA
Avila
J
J
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000378:metabolism; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D005333:Fetus; D006801:Humans; D008297:Male; D016253:Microscopy, Immunoelectron; D008869:Microtubule-Associated Proteins / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism; D010750:Phosphoproteins / Q000032:analysis / Q000378:metabolism; D010766:Phosphorylation; D038461:Proline-Directed Protein Kinases; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051381:Rats; D012016:Reference Values; D016875:tau Proteins / Q000378:metabolism
D008869:Microtubule-Associated Proteins; D010750:Phosphoproteins; C085284:microtubule-associated protein 1B; D016875:tau Proteins; D038461:Proline-Directed Protein Kinases; D017346:Protein Serine-Threonine Kinases