Survival of yogurt-containing organisms and Lactobacillus gasseri (ADH) and their effect on bacterial enzyme activity in the gastrointestinal tract of healthy and hypochlorhydric elderly subjects.
The effect of the live bacterial yogurt cultures, namely Streptococcus thermophilus and Lactobacillus bulgaricus, and a mucosal adhering strain of Lactobacillus gasseri (ADH) on small intestinal and fecal bacterial characteristics was examined in 10 elderly subjects with atrophic gastritis and 23 elderly normal volunteers (11 received yogurt and 12 received ADH). Neither S thermophilus nor L bulgaricus was recovered from the stomach or small intestine of subjects fed yogurt or pasteurized yogurt. ADH was recovered from gastric or small intestinal aspirates in three of four subjects and in the stools of four of five subjects diagnosed with atrophic gastritis. In 11 of 12 normal subjects, ADH was isolated from stools. There was a significant reduction in fecal bacterial enzyme activity in both normal volunteers and subjects with atrophic gastritis after being fed with viable ADH. Adherent strains of bacteria such as ADH are likely to survive passage through the gastrointestinal tract and thus have greater metabolic effects.
US Department of Agriculture Human Nutrition Research on Aging, Tufts University, Boston, MA.
M C
MC
Pedrosa
B B
BB
Golner
B R
BR
Goldin
S
S
Barakat
G E
GE
Dallal
R M
RM
Russell
D000368:Aged; D000369:Aged, 80 and over; D004032:Diet; D005243:Feces / Q000201:enzymology; D005757:Gastritis, Atrophic / Q000382:microbiology*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007583:Jejunum / Q000382:microbiology; D007778:Lactobacillus / Q000201:enzymology*; D008875:Middle Aged; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D009601:Nitroreductases / Q000378:metabolism; D015014:Yogurt / Q000382:microbiology*
D009247:NADH, NADPH Oxidoreductases; D009601:Nitroreductases; C021106:azoreductase; D005966:Glucuronidase