Evaluation of prenatal diagnosis of limb reduction defects by a registry of congenital anomalies.
Prenatal diagnosis performed by ultrasound scan is now a routine part of antenatal care in our region. How many fetal anomalies are actually detected by this procedure? We have used our registry of congenital malformations to answer this question regarding limb reduction defects (LRDs). The mean time of detection of LRDs was 26 weeks of pregnancy (range 16-32 weeks). The sensitivity of prenatal diagnosis of LRDs by ultrasonographic examination was much lower for isolated malformations (fetuses with only one anomaly) than for multiply malformed children with LRDs, 4.0 and 18.2 per cent, respectively. For all cases of LRDs, the percentage of prenatal detection was 11.5. Termination of pregnancy was performed in 6.7 per cent of the cases.
Institut de Puériculture, Hôpitaux Universitaires de Strasbourg, France.
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C
Stoll
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Alembik
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Dott
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Roth
D000013:Congenital Abnormalities / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics; D005121:Extremities / Q000000981:diagnostic imaging; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007621:Karyotyping; D017880:Limb Deformities, Congenital; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care; D012042:Registries; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal