Effects of gliclazide on fibrin network.
Fibrin network structure is altered by diabetes, peripheral vascular disease, and by some drugs. The antidiabetic drug, gliclazide, increases fibrin fiber thickness but reduces whole network permeability. The networks are, however, more lysable. These effects are further examined in this study using electron microscopy. Changes were observed in protein concentrations in fibrin fibers, in fibrin fiber alignment and in fiber porosity. These results show that gliclazide modifies fibrin monomer polymerization so that the fibrin network is rendered more susceptible to fibrinolysis. This pharmacological action of gliclazide may be useful in the treatment of thromboembolism.
Dhall
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DP
Vascular and Thrombosis Research Unit, Woden Valley Hospital, ACT, Australia.
Nair
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CH
D005337:Fibrin / Q000187:drug effects* / Q000648:ultrastructure; D005907:Gliclazide / Q000494:pharmacology*; D006801:Humans; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D013923:Thromboembolism / Q000188:drug therapy
D005337:Fibrin; D005907:Gliclazide