Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus.
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.
Myrup
B
B
Steno Diabetes Center, Gentofte, Denmark.
Hansen
P M
PM
Jensen
T
T
Kofoed-Enevoldsen
A
A
Feldt-Rasmussen
B
B
Gram
J
J
Kluft
C
C
Jespersen
J
J
Deckert
T
T
D000328:Adult; D000419:Albuminuria / Q000188:drug therapy* / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin