Cytokine regulation of mucosal responses: a rational basis for new vaccine delivery strategies.
In this review, cytokine regulation of mucosal responses is discussed in relation to the mucosal immune network and regulation of IgA responses. Based on this understanding, aspects of gene therapy for manipulation of the host environment and vaccine delivery systems are discussed. Although evidence obtained in vitro is briefly reviewed the general focus of this article is on evidence obtained from models in vivo.
Department of Veterinary Pathology, University of Sydney, NSW, Australia.
A J
AJ
Husband
S
S
Bao
W
W
Muir
A J
AJ
Ramsay
I A
IA
Ramshaw
D000818:Animals; D000906:Antibodies / Q000378:metabolism; D016207:Cytokines / Q000502:physiology*; D016503:Drug Delivery Systems; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology*; D014611:Vaccination
D000906:Antibodies; D016207:Cytokines; D007070:Immunoglobulin A