Low levels of hepatic cytochrome P-450 in Mexicans with uncomplicated cholelithiasis.
The multienzymatic complex known as cytochrome P-450 represents one of the most important hemoprotein families of the liver. It participates in the metabolism of steroids, fatty acids, prostaglandins and liposoluble vitamins, and also plays a role in the bioactivation of xenobiotic compounds (generates reactive metabolites which produce acute and chronic lesions in liver tissue). This is a report on the low concentrations of total microsomal P-450 (0.093 +/- SD = 0.069 nMoles/mg protein) found in liver biopsies of 19 mexican patients diagnosed as having biliary lithiasis, as compared to an anglosaxon population with the same liver pathology (0.415 +/- 0.105 nMoles/mg protein). These low values are in agreement with the observation of a high incidence in normal mexicans (91.7%) of poor nifedipine metabolizers. Our findings justify an analyses of hepatic RNAm and cDNA of mexican individuals according to ethnic background, diet and environmental contaminants.
Martínez-Zedillo
G
G
Departamento de Farmacología, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, México D.F.
Amézcua
J
J
González Barranco
D
D
D000328:Adult; D002769:Cholelithiasis / Q000208:ethnology / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D008800:Mexico; D008875:Middle Aged
D003577:Cytochrome P-450 Enzyme System