Biodistribution of haematoporphyrin analogues in a lung carcinoma model.
In an attempt to identify novel compounds useful for the optimization of Photodynamic Therapy (PDT), the tissue localization of new synthetic porphyrins was compared with Photofrin II in nude mice xenografted with a human small cell lung cancer (POVD). Three haematoporphyrin analogues were selected for this study based on prior in vitro photosensitivity screening of a series of 15 such derivatives, as well as on the basis of improved localization in C6 gliomas in mice. Two of the porphyrins yielded better tumour:normal lung ratios than Photofrin II and, of these two, one (P13) is known to exhibit good photosensitization properties both in vitro and in vivo, and is therefore a good candidate as a lead compound for the development of porphyrins suitable for the photodynamic treatment of lung tumours.
Department of Health Physics, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
M
M
Tronconi
A
A
Colombo
M
M
De Cesare
R
R
Marchesini
K W
KW
Woodburn
J A
JA
Reiss
D R
DR
Phillips
F
F
Zunino
D000818:Animals; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D017323:Dihematoporphyrin Ether / Q000378:metabolism* / Q000493:pharmacokinetics; D017324:Hematoporphyrin Derivative / Q000378:metabolism* / Q000493:pharmacokinetics; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014018:Tissue Distribution
D017324:Hematoporphyrin Derivative; D017323:Dihematoporphyrin Ether