Mutagenic and carcinogenic risk of oxygen containing chlorinated C-3 hydrocarbons: putative secondary products of C-3 chlorohydrocarbons and chlorination of water.
Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water. These compounds are mutagenic, genotoxic and carcinogenic. 2-Chloroacroleins are extremely strong mutagens and genotoxins and form 1,N2-cyclic deoxyguanosine adducts. The role of such adducts in mutagenicity and carcinogenicity is discussed.
Eder
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Institute of Toxicology, University of Würzburg, Germany.
Weinfurtner
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D000818:Animals; D002273:Carcinogens; D002728:Chlorohydrins / Q000633:toxicity; D004811:Epichlorohydrin; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens; D010100:Oxygen / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014881:Water Supply
D002273:Carcinogens; D002728:Chlorohydrins; D006843:Hydrocarbons, Chlorinated; D009153:Mutagens; D004811:Epichlorohydrin; D010100:Oxygen