Differential effect of amygdaloid lesions on CRF-41, ACTH and corticosterone responses following neural stimuli.
The effect of amygdaloid (AMG) lesions on changes in median eminence (ME) CRF-41 and serum ACTH and corticosterone (CS) levels following neural stimuli were investigated in rats. In intact animals photic or acoustic stimuli caused CRF-41 depletion from the ME and a rise in serum ACTH and CS levels. In rats with medial or central AMG nuclei lesions, these responses were blocked. Basal AMG lesions were not effective. Also, all groups of animals responded normally to ether stress. These results indicate a differential effect of AMG nuclei on the hypothalamo-pituitary-adrenocortical (HPA) axis and demonstrate that the facilitatory effect of the AMG nuclei on the HPA axis responses involves the release of ME CRF-41, which stimulates ACTH and consequently CS secretion.
Department of Neurology, Hadassah-University Hospital, Jerusalem, Israel.
S
S
Feldman
N
N
Conforti
A
A
Itzik
J
J
Weidenfeld
D000161:Acoustic Stimulation; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D010775:Photic Stimulation; D051381:Rats
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone