Histological study of tibial dyschondroplasia-like lesion from light-type chicks fed cysteine-supplemented diets.
Tibial dyschondroplasia (TD)-like lesions were induced in New Hampshire x Single-Comb White Leghorn cross chicks (NH x SCWL) by feeding excess levels of cysteine. The chicks fed a corn/soybean-meal-based diet had no spontaneous TD. The chicks fed the basal diet supplemented with 1.5% or 3.0% cysteine showed more than 50% TD-like lesions at 10 days of age; in another experiment, 1.6% cysteine induced TD (15%) at 3 weeks of age. A low incidence of rachitic-like lesions was found in Expt. 2 but was not associated with the dietary treatments. The TD-like lesion had a normal upper growth plate and a large mass of cartilage extending into the metaphysis; in contrast, the rachitic-like lesion had a widened upper growth plate. Microscopic examinations of the growth plates showed a widened prehypertrophic zone for the TD-like lesion and a widened proliferative zone for the rachitic-like lesion compared with the normal growth plate.
Department of Nutritional Sciences, University of Wisconsin, Madison 53706.
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Bai
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Cook
D000818:Animals; D002645:Chickens; D003545:Cysteine / Q000008:administration & dosage / Q000633:toxicity*; D004032:Diet / Q000009:adverse effects; D005260:Female; D006132:Growth Plate / Q000473:pathology; D008297:Male; D010009:Osteochondrodysplasias / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000209:etiology / Q000473:pathology*; D012279:Rickets / Q000473:pathology / Q000662:veterinary; D013977:Tibia / Q000473:pathology; D013997:Time Factors
D003545:Cysteine