[The effect of the ecologically adverse factors of a Donets Basin industrial region on the clinico-immunological indices of patients with viral hepatitis A and B].
Clinicoimmunological features of viral hepatitis A and B (VH A and VH B) were studied in residents of unfavorable (from the environmental standpoint) regions. 180 VH A, 86 VII B patients were examined. Clinical picture of VH was characterized by predominance of more severe forms, frequent occurrence of cholestatic variant of VH, high rate of protracted and recurrent (in VH B) course of VH, hepato- and splenomegaly of long duration. The immunologic status was characterized by more pronounced T-lymphopenia, noticeable imbalance of T-helpers and T-suppressors, decrease in the level of immunoglobulins, as well as in phagocytic activity of neutrophilic granulocytes and monocytes in peripheral blood. The use of adaptogens and antioxidants in multimodality treatment promotes rapid normalization of clinicoimmunological parameters in VH.
Petrunia
A M
AM
Frolov
V M
VM
Peresadin
N A
NA
Dekaliuk
I V
IV
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D004463:Ecology; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D006506:Hepatitis A / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007221:Industry; D008297:Male; D008875:Middle Aged; D014455:Ukraine
D004785:Environmental Pollutants
Vliianie ékologicheski neblagopriiatnykh faktorov industrial'nogo regiona Donbassa na kliniko-immunologicheskie pokazateli u bol'nykh virusnym gepatitom A i B.