[Metabolic acidosis in the 32nd week of pregnancy--uncontrolled diabetes in pregnancy, dehydration or sequela of tocolysis?].
We describe a case of keto- and lactic acidosis in a 22 year old, healthy woman hospitalized for preterm labor at week 32 of gestation. One former pregnancy was normal. Blood glucose level at admission was 115 mg/dl after 8 mg of betamethasone. Continuous salbutamol infusion was used for management of preterm labour. 18 hours later, the patient complained about nausea and dyspnoea followed by tachypnoea and hyperventilation. Blood gas analysis showed severe metabolic acidosis (ph 7.25, BE-17.5, pO2 114 mm Hg, pCO2 15.5 mm Hg). At this moment blood glucose level was 178 mg/dl. Ketone bodies in urine were positive, serum lactate level was also elevated at 8.6 mmol/l. Cesarean section was performed because of prolonged fetal bradycardia. 6 months post partum type-I-diabetes could be excluded. We conclude that this case of acidosis was due to both, beta-2-adrenergic treatment and beginning gestational diabetes.
Sektion Spezielle Anästhesie, Universitätsklinik für Anästhesiologie, Universität Ulm.
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Gmehlin
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Stenz
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Stoz
D000140:Acidosis, Lactic / Q000097:blood / Q000139:chemically induced / Q000209:etiology*; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects; D001786:Blood Glucose / Q000378:metabolism; D002585:Cesarean Section; D003681:Dehydration / Q000097:blood / Q000150:complications*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis*; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000139:chemically induced / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000175:diagnosis*; D015145:Tocolysis
D001786:Blood Glucose; D000420:Albuterol
Metabolische Azidose in der 32. Schwangerschaftswoche--Entgleister Gestationsdiabetes, Dehydration oder Tokolysefolge?