Disposition of human drug preparations in the horse. III. Orally administered alclofenac.
Concentrations of the non-steroidal anti-inflammatory drug (NSAID) alclofenac were determined by a sensitive high performance liquid chromatographic procedure in plasma and urine of horses following oral administration of a dose of 3 g. In plasma, alclofenac was present in detectable concentrations for 72 h. The plasma disposition in individual horses was best described by a bi-compartmental model with two successive rate constants ka1 = 0.05 +/- 0.06 h-1 and ka2 = 0.06 +/- 0.01 h-1. Alclofenac half-lives t1/2 alpha and t1/2 beta were 1.0 +/- 0.8 h and 6.9 +/- 1.5 h, respectively. Maximal concentrations (38.9 +/- 16.2 micrograms/ml) were obtained after 8.5 +/- 2.4 h. Alclofenac was detected in urine for at least 48 h after dosing. The percentage of the dose excreted as unchanged alclofenac in 12 h was very low (0.68 +/- 0.19%), total (free+conjugated) alclofenac accounted for 2.16 +/- 0.55% of the dose.
Vakgroep Farmacologie, Farmacie & Toxicologie, Faculteit Diergeneeskunde, Universiteit Gent, Belgium.
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Delbeke
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Landuyt
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Debackere
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D001798:Blood Proteins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D006207:Half-Life; D006736:Horses / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D010648:Phenylacetates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D011485:Protein Binding
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001798:Blood Proteins; D010648:Phenylacetates; C084615:alclofenac