Augmentation of host resistance against bacterial infection by treatment with leustroducsin B, a new CSF inducer.
We tested the in vivo activity of leustroducsin B (LSN B), a new colony-stimulating factor (CSF) inducer isolated from the culture broth of Streptomyces platensis, with mice infected with Escherichia coli. Treatment with LSN B augmented the host resistance to lethal infection of E. coli at doses between 0.1 mg/kg and 1 mg/kg. Serum interleukin-6 (IL-6) levels were found to increase after this treatment, and superoxide anion generation of neutrophils was enhanced in vivo, suggesting that LSN B augmented the host resistance at least in part by inducing IL-6, which subsequently enhanced the bactericidal activity of the neutrophils.
Kohama
T
T
Biological Research Laboratory, Sankyo Co., Ltd., Tokyo, Japan.
Katayama
T
T
Inukai
M
M
Maeda
H
H
Shiraishi
A
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D004927:Escherichia coli Infections / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D007109:Immunity / Q000187:drug effects; D015850:Interleukin-6 / Q000097:blood; D007783:Lactones / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011753:Pyrones; D013481:Superoxides / Q000378:metabolism
D000900:Anti-Bacterial Agents; D003115:Colony-Stimulating Factors; D015850:Interleukin-6; D007783:Lactones; D009943:Organophosphorus Compounds; D011753:Pyrones; D013481:Superoxides; C084414:leustroducsin B