Recent concepts of lipoprotein pathophysiology.
Molecular genetic approaches have added greatly to the understanding of the human hyperlipoproteinemias. Studies in mice have added interesting new information. Transgenic mice over-expressing or deficient in various individual proteins important in lipoprotein metabolism have reproduced some dyslipidemias and permitted further pinpointing of the functions of apolipoproteins, lipoprotein receptors, lipid transfer proteins and enzymes. Cross-breeding of mice with single defects has reproduced certain dyslipidemia syndromes and permits examination of the combined etiologic effects of more than one gene.
Division of Atherosclerosis, Washington University School of Medicine, St. Louis, MO 63110.
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D000818:Animals; D006949:Hyperlipidemias / Q000503:physiopathology*; D007009:Hypolipoproteinemias / Q000503:physiopathology*; D008074:Lipoproteins / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic
D008074:Lipoproteins