Dissociation of selective renal venous plasma endothelin-1 activity and corresponding plasma renin activity in a patient with hypertension, severe stenosis of unilateral renal artery and ipsilaterally decreased renal function.
Plasma endothelin-1 (ET-1)-like immunoreactivity in selective renal venous blood and peripheral venous blood was measured and compared with plasma renin activity and aldosterone level in a 26-year-old woman with suspected renovascular hypertension due to stenosis of the left renal artery. Although there was no significant step-up in plasma renin activity between the right and the left renal vein, left/right ratio of plasma ET-1 in the renal vein was 2.18. This case suggests that ET-1 may be one of the hypertensive mechanisms of suspected renovascular hypertension in addition to the renin-angiotensin system.
Department of Urology, Niigata University School of Medicine, Japan.
M
M
Takeda
T
T
Komeyama
Y
Y
Katayama
T
T
Tsutsui
T
T
Mizusawa
H
H
Takahashi
H
H
Go
M
M
Tamaki
D000328:Adult; D000450:Aldosterone / Q000097:blood; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology*; D007677:Kidney Function Tests; D015609:Organotechnetium Compounds; D011863:Radioimmunoassay; D011877:Radionuclide Imaging; D012078:Renal Artery Obstruction / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D012083:Renin / Q000097:blood*; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
D016232:Endothelins; D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D000450:Aldosterone; D004113:Succimer; D012083:Renin