Proton NMR spectroscopy of plasma lipoproteins: a marker of the immune function in cancer disease?
1H-NMR spectroscopy of cancer plasma statistically detects significant narrowing of the methyl and methylene line widths. This change is due to relative increase in light density lipoproteins (VLDL and LDL) compared to heavy density lipoproteins (HDL). This observation had raised great hopes for a simple and universal screening test of cancer patients. Furthermore, the same signal can be observed in the plasma of pregnant women and heart transplanted patients undergoing an immunosuppressive treatment. This signal disappears after child's birth and during graft rejection processes. These observations suggest that the test initially proposed by Fossel in 1986 reveals a specific immunological status developed by the organism in "symbiosis" with "foreign" cells, rather than a cancerous disease.
Leray
G
G
Laboratoire de Résonance Magnétique en Biologie et Medicine, Rennes, France.
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D000276:Adjuvants, Immunologic / Q000097:blood; D000818:Animals; D015317:Biogenic Polyamines / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood*; D002455:Cell Division / Q000502:physiology; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009369:Neoplasms / Q000097:blood* / Q000276:immunology*; D011247:Pregnancy; D011522:Protons; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000276:Adjuvants, Immunologic; D015317:Biogenic Polyamines; D014408:Biomarkers, Tumor; D008074:Lipoproteins; D011522:Protons; D014409:Tumor Necrosis Factor-alpha