[A method of determination of cholesterol contents on the surface of the human skin and prospects of its use. I. Atherosclerosis].
Proceeding from published data on lipid content and composition in human skin and on the possible relationship between cholesterol level in skin biopsy specimens and status of blood vessels, the authors measured cholesterol content in skin layers available for external extraction in patients with atherosclerosis with different types of dyslipoproteinemias. Effective conditions of extraction were developed permitting after external rapid atraumatic treatment extraction of the maximally possible amount of cholesterol, 1.5 to 1.6 mkg from 1 cm2 of the palm skin surface, this being a constant value for each examinee (coefficient of variations after 3-4 repetitions 5%). Though slight, but statistically reliable increase of the amount of surface-extractable cholesterol was observed in atherosclerosis patients. This parameter did not correlate with the blood serum concentration of lipid components. A correlation (r = 0.54, p < 0.001) was observed with an only serum lipoprotein parameter, the so-called dyslipoproteinemia coefficient representing the sum of "atherogenic" parameters (cholesterol+triglycerides) divided by alpha-lipoprotein cholesterol. Measurements of surface-extractable skin cholesterol may be used as an available discriminant of atherosclerosis; the method seems to find application in other diseases as well.
Khalilov
E M
EM
Fortinskaia
E S
ES
Nikitina
N A
NA
Kogan
E M
EM
Torkhovskaia
T I
TI
D001161:Arteriosclerosis / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D001669:Biochemical Phenomena; D001671:Biochemistry; D002784:Cholesterol / Q000032:analysis* / Q000097:blood / Q000302:isolation & purification; D004817:Epidermis / Q000737:chemistry; D006801:Humans; D012867:Skin / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties
D002784:Cholesterol
Metod opredeleniia soderzhaniia kholesterina poverkhnosti kozhi cheloveka i perspektivy ego ispol'zovaniia. 1. Ateroskleroz.