Sustained release metoclopramide for prophylaxis of post-operative nausea and vomiting.
Oral metoclopramide may be given as a premedicant to reduce post-operative nausea and vomiting, but there is little evidence that it is effective. We studied the anti-emetic action of a sustained release formulation of metoclopramide (Gastromax 30 mg) in 39 fit women undergoing inpatient laparoscopy under general anaesthesia with a standardized anaesthetic technique in a double-blind placebo-controlled trial. No benefit was demonstrated. (Incidences: nausea: 13 of 20 patients [placebo] and 13 of 19 [metoclopramide]; vomiting: 13 of 20 and 12 of 19.)
Department of Anaesthesia, Derbyshire Royal Infirmary, UK.
R H
RH
Elliott
S G
SG
Graham
J P
JP
Curran
D000284:Administration, Oral; D000328:Adult; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D017558:Elective Surgical Procedures; D005260:Female; D006757:Hospital Units; D006801:Humans; D015994:Incidence; D010535:Laparoscopy; D008787:Metoclopramide / Q000008:administration & dosage / Q000627:therapeutic use*; D009325:Nausea / Q000517:prevention & control*; D010919:Placebos; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011997:Recovery Room; D013693:Temazepam / Q000008:administration & dosage / Q000627:therapeutic use; D014839:Vomiting / Q000517:prevention & control*
D003692:Delayed-Action Preparations; D010919:Placebos; D013693:Temazepam; D008787:Metoclopramide