Vintage reds and whites: combinatorial transcription factor utilization in hematopoietic differentiation.
Pluripotent hematopoietic stem cells can differentiate into a number of distinct specialized cell types; however, no single lineage-specific master regulators have been identified that can activate individual patterns of gene expression. Recent evidence suggests that such lineage determination is regulated by a combinatorial matrix of regulatory proteins with overlapping tissue specificities which cooperate to define individual cell types.
Ness
S A
SA
Northwestern University Department of Biochemistry, Molecular Biology and Cell Biology, Evanston, Illinois 60208-3500.
Engel
J D
JD
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D050981:Erythroid-Specific DNA-Binding Factors; D004920:Erythropoiesis / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000235:genetics; D020598:Proto-Oncogene Proteins c-myb; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D014157:Transcription Factors