Malignant change in cutaneous neurofibromas--case reports.
Neurofibromatosis is the most common single gene disorder to affect the nervous system, with an estimated incidence of 1 in 3000 live births. Neurofibromatosis (NF) may be classified into von Recklinghausen NF (NFI) and bilateral acoustic NF (NFII) based on the distribution of lesions. The most common lesion associated with the von Recklinghausen type is the neurofibroma. Various complications are associated with neurofibromatosis, the most feared of which is malignant change in the neurofibroma. This article describes the study of 7 cases of proven malignant change in neurofibromas with regards to presentation, clinical progress and treatment followed by a review of the present literature.
Khoo
A K
AK
Department of Plastic Surgery, Singapore General Hospital.
Foo
C L
CL
D000328:Adult; D002471:Cell Transformation, Neoplastic; D005153:Facial Neoplasms / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009455:Neurofibroma / Q000473:pathology* / Q000503:physiopathology; D018319:Neurofibrosarcoma / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology* / Q000503:physiopathology; D012888:Skull Neoplasms / Q000209:etiology / Q000503:physiopathology / Q000628:therapy