[Changes in the contents of plasma SOD and MDA in 50% III degree burn dogs after delayed fluid replacement].
The plasma SOD and MDA content were determined in 50% III degree burn dogs with delayed fluid replacement. The results showed that the activity of plasma total SOD and CuZn-SOD rapidly declined and were obviously lower during the first 5 days postburn than preburn values, while the content of Mn-SOD did not show significant change. The plasma MDA was evidently elevated in 24 hour but returned to the normal level in 48-72 hours after burn, however it distinctly rose again after 72 hours post-burn. The results suggest that delayed fluid replacement induced generation of free radicals after burn injury, with the result of the occurrence of lipid peroxidation.
Cui
L
L
Burn Institute, Third Military Medical College, Chongqing.
Yang
Z
Z
Cheng
F
F
D000818:Animals; D002056:Burns / Q000378:metabolism* / Q000628:therapy*; D004285:Dogs; D005440:Fluid Therapy; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors
D008315:Malondialdehyde; D013482:Superoxide Dismutase