[Effect of Salvia miltiorrhiza on lipid peroxidation antioxidant enzymes activity in patients with chronic cor pulmonale].
This paper studied the effect of Salvia miltiorrhiza (SM) on plasma lipid peroxidation (LPO), RBC superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activity in patients with chronic cor pulmonale. 30 patients were randomly divided into two treatment groups (routine and SM). The four parameters have been measured in 22 healthy subjects as control and patients of two treatment groups. The results showed: (1) Before treatment both treatment groups had significantly higher LPO and SOD and markedly lower GSH-Px and CAT level than that of healthy control (P < 0.001) respectively. (2) After treatment in routine group the four parameters have normalized, P < 0.05. (3) Routine treatment was compared with SM treatment, except SOD, the other three parameters were significantly different between two treatment groups (P < 0.001). The increased levels of GSH-Px and CAT and the decreased LPO were significantly greater in SM group than routine treatment (P < 0.001). The above-mentioned results indicated patients with cor pulmonale in acute exacerbation their lipid peroxide reaction was enhanced, the antioxidant enzymes lost their balance. SM could attenuate markedly lipid peroxide reaction, adjust the imbalance of the three antioxidant enzymes, enhance body's defence capability against damage of active oxygen free radical induced lipid peroxidation.
Zhang
P T
PT
Nanjing Steelworks Hospital.
Chen
Z R
ZR
D000328:Adult; D002374:Catalase / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D010936:Plant Extracts; D011660:Pulmonary Heart Disease / Q000097:blood / Q000188:drug therapy*; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D010936:Plant Extracts; D002374:Catalase; D005979:Glutathione Peroxidase