Hypercalcemia caused by PTH-rP associated with lung metastasis from urinary bladder carcinoma: an autopsied case.
We analyzed the parathyroid-related protein (PTH-rP) content in tissue specimens obtained from a 61-year-old man with hypercalcemia associated with lung metastasis from urinary bladder carcinoma using radioimmunoassay and immunohistochemistry. Radioimmunoassay showed that the PTH-rP content was higher in metastatic lung tumor tissue than in non-tumorous lung tissue. Immunohistochemical analysis revealed the presence of PTH-rP in tumor cells. Furthermore, proliferation of osteoclasts was found in bone marrow at autopsy. The results suggest that PTH-rP induced humoral hypercalcemia of malignancy in a patient with urinary bladder cancer.
Yoshida
T
T
First Department of Internal Medicine, School of Medicine, Fukuoka University.
Suzumiya
J
J
Katakami
H
H
Kimura
N
N
Hisano
S
S
Kikuchi
M
M
Okumura
M
M
D001853:Bone Marrow / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000150:complications* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008168:Lung / Q000737:chemistry / Q000473:pathology; D008175:Lung Neoplasms / Q000737:chemistry / Q000150:complications* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D010010:Osteoclasts / Q000473:pathology; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000032:analysis*; D011863:Radioimmunoassay; D001749:Urinary Bladder Neoplasms / Q000473:pathology*
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins