The effects of ricin on the sympathetic vascular neuroeffector system of the rabbit.
Ricin is a toxic lectin that inhibits protein synthesis. Because ricin decreases arterial pressure and causes cardiovascular collapse, its effects on the vascular neuroeffector system were investigated. Rabbits were given either of two doses of ricin, and then norepinephrine (NE) release from aorta to transmural stimulation, NE uptake into aorta, NE content of aorta, monoamine oxidase activity, and catechol-O-methyl transferase activity in aorta were determined 18 hours, 4 days or 7 days later. Norepinephrine uptake and enzyme activities in the aorta were not altered by ricin administration. Norepinephrine release and content of aorta were increased at most time periods following ricin administration, significantly so for NE content at 4 days and for release at 18 hours following the lower dose of ricin. We conclude that the mechanisms involved in the release of NE from sympathetic nerves in the vasculature are not impaired by ricin administration, but rather show changes that indicate increased compensatory activity.
University of Oklahoma HSC, College of Pharmacy, Oklahoma City 73190.
V J
VJ
Christiansen
C H
CH
Hsu
C P
CP
Robinson
D000818:Animals; D001012:Aorta, Abdominal / Q000201:enzymology / Q000294:innervation / Q000378:metabolism; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004558:Electric Stimulation; D004563:Electrochemistry; D008995:Monoamine Oxidase / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000201:enzymology / Q000294:innervation; D009451:Neuroeffector Junction / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism; D011817:Rabbits; D012276:Ricin / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology
D012276:Ricin; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D009638:Norepinephrine