Modification of the responses of endothelin-1 to exhaustive physical exercise under simulated high-altitude conditions with acute hypoxia.
To assess whether acute alveolar hypoxia leads to the release of endothelin-1 (ET) in vivo, ET, cortisol (CORT), and lactate (LA) levels were determined in 15 healthy subjects at rest and during exhaustive incremental cycle ergometry on two separate test days. The subjects were to breathe a gas mixture with reduced O2 content ([H] fraction of inspired O2, 0.14) on one day and normal air on the other (N). Modified responses of LA and CORT to exhaustive incremental cycle ergometry on the H day indicated elevated anaerobic tissue metabolism and increased physical stress. With acute alveolar hypoxia, the response of ET to exhaustive physical labor was found to be augmented.
Department of Internal Medicine, University Hospital Frankfurt am Main, Germany.
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Kullmer
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Jungmann
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Haak
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Usadel
D000208:Acute Disease; D000328:Adult; D000531:Altitude; D016232:Endothelins / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D000860:Hypoxia / Q000097:blood*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D005082:Physical Exertion
D016232:Endothelins; D007773:Lactates; D019344:Lactic Acid; D006854:Hydrocortisone