Correlations between platelet aggregation, fibrinolysis, peripheral and central serotonergic measures in subhuman primates.
We have studied the relationships between whole blood and plasma serotonin (5-hydroxytryptamine, 5-HT), its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) and serum lipids, platelet aggregation in the whole blood and in the platelet-rich plasma (PRP), and some fibrinolytic parameters in monkeys. Plasma 5-HT was found to be positively related to 5-HT- and ADP-induced platelet aggregation, tissue plasminogen activator (tPA) activity, serum cholesterol and LDL-cholesterol, whereas 5-HT in cerebrospinal fluid correlated inversely with serum cholesterol. Plasminogen activator inhibitor (PAI) activity was positively related to LDL. Euglobulin clot lysis time was related to both tPA and PAI activities. The significance of these findings and the possible role of 5-HT in atherogenesis and hemostasis are discussed.
Department of Physiology, Hamamatsu University School of Medicine, Shizuoka, Japan.
J
J
Malyszko
T
T
Urano
R
R
Knofler
H
H
Ihara
I
I
Shimoyama
K
K
Uemura
Y
Y
Takada
A
A
Takada
D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D008297:Male; D010974:Platelet Aggregation / Q000502:physiology*; D012701:Serotonin / Q000097:blood / Q000134:cerebrospinal fluid / Q000494:pharmacology*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D012701:Serotonin; D002784:Cholesterol