[Molecular and clinical abnormalities of apolipoprotein A-I].
Several epidemiological and clinical studies have shown an inverse correlation between low plasma concentration of high density lipoprotein (HDL) cholesterol as well as its major protein component, apolipoprotein A-I (apo A-I), and the risk of coronary artery disease. Apo A-I plays an important role in a reverse cholesterol transport. In this model, HDL mediates the cholesterol flux from peripheral cells to the liver. The structure and function of HDL-deficiency syndromes and apo A-I variants provides genetic markers of whether the presence of these molecular defects accounts for low HDL cholesterol levels and the coronary risk.
Department of Internal Medicine, School of Medicine, Fukuoka University.
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Y
Takada
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Sasaki
D016632:Apolipoprotein A-I / Q000172:deficiency* / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood / Q000172:deficiency; D003327:Coronary Disease; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009154:Mutation; D012306:Risk
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL