Risk of atherosclerosis in women six years after uterine leiomyoma surgery as compared with healthy women.
44 women at the age between 40 and 60, who underwent uterine leiomyoma surgery six years previously and 45 healthy women were examined for total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglycerides (TG) and 17 beta-estradiol (E2). The value of the atherogenic coefficient [sequence: see text] and [sequence: see text] were determined. The clinical condition of the women was also evaluated. It was shown that independently on the extent of surgery, significantly (p < 0.01 and p < 0.001) higher values of LDL-C and lower values (p < 0.05) of atherogenic coefficients of [sequence: see text] were recorded, which is evidence of risk atherosclerosis and coronary heart disease (CHD) in all groups of women. A greater intensity of atherosclerotic changes in women with bilateral oophorectomy (group B'beta) may be connected both with older age and a higher body weight inducing these processes and is evidence of pathogenetic disorders caused by laparotomy. We confirmed that oophorectomy in women with leiomyoma during the perimenopausal period does not result in atherosclerosis and CHD risk when preserving the ovaries during laparotomy.
Kamiński
B T
BT
1st Department of Obstetrics and Gynecology, Silesian School of Medicine, Bytom, Poland.
Rzempołuch
J
J
Wiczkowski
A
A
Dyla
L
L
Sobolewska
M
M
D000328:Adult; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D007889:Leiomyoma / Q000601:surgery*; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014594:Uterine Neoplasms / Q000601:surgery*
D014280:Triglycerides; D004958:Estradiol; D002784:Cholesterol