[Lipid peroxidation, antioxidant enzyme activity and trace element concentration in II and III trimester of pregnancy in pregnant women with diabetes].
The aim of the study was to evaluate the concentration of malondialdehyde (MDA)--end product of lipid peroxidation, activity of antioxidant enzymes: superoxide dismutase (CuZn-SOD), glutathione peroxidase (GSH-Px), and catalase (Cat) as well as selenium (Se), zinc (Zn) and copper (Cu) concentration in erythrocytes in 63 patients divided into the three groups: I--control group, II--normal pregnancy, III--pregnant type I diabetics. All parameters were investigated in hemolysate of erythrocytes. MDA concentration increased significantly in pregnant women when compared with control group, as well as in pregnant diabetics when compared with healthy pregnant women. The activity of GSH-Px decreased significantly in pregnant diabetics in comparison with groups I and II. The activity of CuZn-SOD and Cat was significantly lower in III group than in control group. The concentration of Se and Zn decreased, and the concentration of Cu increased significantly in pregnant diabetics in comparison with the other groups. No differences in concentration of MDA, Se, Zn, Cu and activity of GSH-Px were found between particular trimesters in studied patients. The activity of CuZn-SOD and Cat were significantly higher in III trimester than in II one in pregnant diabetics while the activity of GSH-Px remained unchanged during pregnancy.


CONCLUSIONS
Increased lipid peroxidation and the lack of compensatory mechanisms--an increase in antioxidant enzymes activity as well as disorder of trace elements concentration are found in pregnant type I diabetics.
Katedra i Klinika Chorób Wewnetrznych i Zawodowych Slaskiej Akademii Medycznej w Zabrzu.
K
K
Twardowska-Saucha
W
W
Grzeszczak
B
B
Lacka
J
J
Froehlich
D
D
Krywult
D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008315:Malondialdehyde / Q000097:blood; D010088:Oxidoreductases / Q000378:metabolism*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000378:metabolism; D011263:Pregnancy Trimester, Third / Q000378:metabolism; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D014131:Trace Elements / Q000097:blood*
D014131:Trace Elements; D008315:Malondialdehyde; D010088:Oxidoreductases
Peroksydacja lipidów, aktywność enzymów antyoksydacyjnych oraz stezenie metali śladowych w II I III trymestrze ciaźy u cieźarnych z cukrzyca.