Synthesis and separation of optically active compounds. Part II.
This review is the second part of an article devoted to the synthesis and separation of optically active compounds. This article deals mainly with chiral chromatography which represents an important component of the state of art for the preparation of enantiomers, as illustrated by a description and a classification of the main packing materials available to date. The various phases are based on different principles of molecular recognition and show advantages and drawbacks according to the molecules to separate. The preparative aspect of this method is particularly emphasized here and in the same context, trends and future developments are mentioned.
Sepracor Inc., Marlborough, MA 01752.
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Gao
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Boschetti
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Guerrier
D002851:Chromatography, High Pressure Liquid / Q000145:classification / Q000379:methods*; D009904:Optical Rotation