Unusual case of leukoencephalopathy after bone marrow transplantation.
A girl with chronic myeloid leukemia received bone marrow transplantation with total body irradiation as part of a conditioning regimen. She developed leukoencephalopathy about 50 days after transplant. There was permanent neurologic impairment afterward. She had not received any cranial irradiation or intrathecal chemotherapy before transplant. She had received 10 months of interferon treatment before transplant, which might have played a part in the development of leukoencephalopathy.
Department of Pediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin.
C K
CK
Li
W H
WH
Kwan
M M
MM
Shing
P M
PM
Yuen
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D003711:Demyelinating Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000628:therapy; D011994:Recombinant Proteins; D014057:Tomography, X-Ray Computed; D014916:Whole-Body Irradiation
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins