Molecular characterization of a novel, serologically detectable, HLA-C allele: Cw*1602.
Cw*1602, a novel HLA-C allele belonging to the newly assigned Cw*16 group, has been cloned and sequenced from a Spanish Caucasoid cell expressing a "Cw6.2" phenotype. Some of the polymorphic substitutions of the new allele, and linkage disequilibrium to B51, had been predicted on the basis of previously published studies. The primary structure of Cw*1602 is in agreement with its serologic reactivity and, in comparison with that of Cw*1601, underlines the dimorphism of HLA-C molecules at residues 77 and 80 of the alpha 1-domain alpha helix.
Immunology Department, Puerta de Hierro Hospital, Madrid, Spain.
C
C
Vilches
M J
MJ
Herrero
R
R
de Pablo
M E
ME
Moreno
M
M
Bunce
M
M
Kreisler
D000483:Alleles; D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D002460:Cell Line; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data
D015236:HLA-C Antigens