The Sex combs reduced gene of Drosophila melanogaster has multiple transcripts.
The Sex combs reduced (Scr) homeotic gene of Drosophila melanogaster specifies the development of structures within the most posterior head segment, the labium and the most anterior thoracic segment, the prothorax or T1. Here, the structure of Scr and correct sequence of the SCR protein are presented. Scr encodes a 417-amino-acid DNA-binding protein with sequence similarity to the mouse homologues, HOXA5, B5 and C5. The greatest similarity is within the DNA-binding homeodomain (hdm); shorter conserved motifs are found near the N terminus and a region N-terminal to the hdm. As with most of the D. melanogaster homeotic genes, Scr has alternative exons.
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305-5247.
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D005091:Exons; D005801:Genes, Homeobox; D007301:Insect Hormones / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors
D029721:Drosophila Proteins; D007301:Insect Hormones; D012333:RNA, Messenger; C059627:Scr protein, Drosophila; D014157:Transcription Factors; D004247:DNA