Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways.
Beta-catenin is a cytosolic protein originally identified through its association with the cadherin class of cell-adhesion proteins. However, recent studies have demonstrated that there are cadherin-independent pools of beta-catenin and that beta-catenin binds at least one other protein, the product of the tumor-suppressor gene APC. Furthermore, beta-catenin is the target of two signal transduction pathways mediated by the proto-oncogenes src and wnt-1. This raises the possibility that beta-catenin plays a pivotal role in balancing cellular responses to both adhesive and proliferative signals.
Hinck
L
L
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305.
Näthke
I S
IS
Papkoff
J
J
Nelson
W J
WJ
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology*; D015688:Oncogene Protein pp60(v-src) / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins; D051176:beta Catenin
D003598:Cytoskeletal Proteins; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins; D051176:beta Catenin; D015688:Oncogene Protein pp60(v-src)