[Immune system indices for the prediction of the course of human immunodeficiency virus infection].
In 25 persons having HIV infection with different dynamics of the progress of the disease the content of lymphocyte populations was studied (by the methods of rosette formation and with the use of monoclonal antibodies) and the rosette-forming and functional metabolic activity of neutrophils was determined. In comparison with patients with a stable course of HIV, patients with relatively rapid progress infection were found to have a significantly lesser amount of E-rosette-forming cells (E-RFC), active E-RFC, theophylline resistant E-RFC, E-rosette-forming neutrophils (E-RFN) and active E-RFN in combination with a significantly higher neutrophil and phosphatase activity and a significantly higher content of cation proteins. These characteristics may be used as criteria for prognosis of HIV infection progression.
Gabrilovich
D I
DI
Serebrovskaia
L V
LV
Khabarova
V V
VV
Kravchenko
A V
AV
Avdeeva
L A
LA
Shalygina
N B
NB
Pokrovskiĭ
V V
VV
D000328:Adult; D000704:Analysis of Variance; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology; D011379:Prognosis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology; D013997:Time Factors
Nekotorye pokazateli immunnoĭ sistemy dlia prognozirovaniia techeniia infektsii, vyzyvaemoĭ virusom immunodefitsita cheloveka.