Biocidal action of chlorhexidine is annulled by nicotinic acid.
An analytical system comprising a bacterium and a protozoan was used to pinpoint the metabolic lesion whereby chlorhexidine (CLX) produced cell death. Nicotinic acid but not nicotinamide annulled the biocidal action of CLX. The results suggest that CLX may not permit bioconversion of nicotinamide to nicotinic acid to annul the growth inhibition induced by CLX.
Baker
H
H
Department of Preventive Medicine and Community Health and Medicine, New Jersey Medical School, Newark 07107.
Frank
O
O
DeAngelis
B
B
Baker
E R
ER
D000818:Animals; D002710:Chlorhexidine / Q000494:pharmacology*; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects; D056890:Eukaryota / Q000187:drug effects; D009525:Niacin / Q000378:metabolism / Q000494:pharmacology*; D009536:Niacinamide / Q000378:metabolism / Q000494:pharmacology
D009536:Niacinamide; D009525:Niacin; D002710:Chlorhexidine