Behavioural assessment of pinealectomy and foetal pineal gland transplantation in rats: Part II.
Pineal gland is an endocrine organ which exerts regulatory effects on the activity of various organs and systems. The present study was undertaken to highlight in experimental animals the possible integrative function of this endocrine organ on a behavioural pattern. Pinealectomy and foetal pineal gland transplantation to a subpial cortical area close to the pinealectomized region was performed. Behaviour was defined through motor activity induced by low (2 mg/kg) and high (10 mg/kg) doses of amphetamine in rats. It was shown that pinealectomy produced significant different patterns of behaviour induced by low and high doses of amphetamine. In sham operated animals low dose amphetamine induced a significant locomotor stimulation but without stereotyped activity. High dose amphetamine induced stereotyped activity. After pinealectomy even low dose amphetamine produced the behavioural pattern of stereotyped activity resembling a high dose amphetamine-induced behaviour. This differential effect of amphetamine, seen in pinealectomized rats, was completely restored after transplantation. On the other hand, melatonin treatment did not generate a significant alteration of behavioural profile either in the control or pinealectomized group of rats. Results are discussed with regard to the general regulatory function of the pineal gland.
Department of Neurosurgery, Hacettepe University, Faculty of Medicine, Sihhiye, Ankara, Turkey.
S
S
Palaoglu
O
O
Palaoglu
E S
ES
Akarsu
I H
IH
Ayhan
T
T
Ozgen
A
A
Erbengi
D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D016332:Fetal Tissue Transplantation; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology; D010870:Pineal Gland / Q000196:embryology / Q000637:transplantation*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D000661:Amphetamine; D008550:Melatonin