Chromosomal assignment of the heparin-binding cytokine genes MDK and PTN in mouse and man.
MDK and PTN are two members of a family of heparin-binding cytokines thought to be involved in a number of developmental processes. The locations for these genes were determined in man and mouse using somatic cell hybrid analysis and interspecific backcross analysis. Human MDK was mapped to 11p13-->p11. MDK in the mouse (Mdk) was mapped to a syntenic region of mouse Chromosome 2. A pseudogene of Mdk was mapped to mouse Chromosome 11. The closely related human gene PTN was mapped to a separate location on human chromosome region 7q22-->qter.
Molecular Biology Research Section, American Cyanamid Company, Pearl River, NY.
B
B
O'Hara
N A
NA
Jenkins
D J
DJ
Gilbert
N G
NG
Copeland
T B
TB
Shows
R L
RL
Eddy
P
P
Böhlen
I
I
Kovesdi
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003433:Crosses, Genetic; D016207:Cytokines / Q000235:genetics*; D005260:Female; D006133:Growth Substances / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D000078792:Midkine; D009115:Muridae
D002352:Carrier Proteins; D016207:Cytokines; D006133:Growth Substances; C066845:pleiotrophin; D000078792:Midkine