Rapid development of D1 and D2 dopamine receptor supersensitivity as indicated by striatal and pallidal Fos expression.
Rats were injected with a single dose of the monoamine-depleting agent reserpine (5 mg/kg s.c.) or its vehicle. Twenty-four hours later rats were injected with either the selective D1 agonist SKF 38393 (5 mg/kg i.p.), the selective D2 agonist quinpirole (0.1 mg/kg i.p.) or saline, and perfused 2 h later. Fos-like immunoreactivity was visualized using a polyclonal antibody to the Fos protein and standard ABC methods. Reserpine rendered striatal D1 and D2 receptors supersensitive as indicated by 10- to 12-fold increases in striatal and pallidal Fos immunoreactivity. The short latency of the development of both D1 and D2 supersensitivity limits the candidate causative mechanisms to those that occur within hours of the initiating stimulus.
Department of Physical Medicine & Rehabilitation, University of California, Irvine 92717-4550.
G J
GJ
LaHoste
J F
JF
Marshall
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D018491:Dopamine Agonists / Q000494:pharmacology; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology; D004873:Ergolines / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology*; D016762:Genes, fos / Q000187:drug effects / Q000502:physiology*; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D011699:Putamen / Q000187:drug effects / Q000378:metabolism; D019257:Quinpirole; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000819:agonists / Q000187:drug effects*; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology
D018491:Dopamine Agonists; D004873:Ergolines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D012110:Reserpine