Muscle extract of hedgehog, Erinaceus europaeus, inhibits hemorrhagic activity of snake venoms.
The antihemorrhagic activity of muscle extract of hedgehog, Erinaceus europaeus, was tested on various snake venoms with hemorrhagic activity. The extract inhibited strongly hemorrhagic activity of venoms from Bitis arietans, Bothrops jararaca and Vipera latastei gaditana, and remarkably that of venoms from Agkistrodon halys blomhoffi, Bitis gabonica rhinoceros, Bitis nasicornis, Bothrops atrox asper, Crotalus horridus horridus and Vipera berus. The antihemorrhagic activity against eight other snake venoms was below the detection level.
Department of Biochemistry and Cell Biology, National Institute of Health, Tokyo, Japan.
T
T
Omori-Satoh
Y
Y
Nagaoka
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D
Mebs
D000818:Animals; D000997:Antivenins / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001798:Blood Proteins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D017837:Bothrops; D003435:Crotalid Venoms / Q000633:toxicity; D006364:Hedgehogs / Q000378:metabolism*; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy*; D009132:Muscles / Q000378:metabolism*; D012910:Snake Venoms / Q000633:toxicity*; D014757:Viper Venoms / Q000633:toxicity
D000997:Antivenins; D001798:Blood Proteins; D003435:Crotalid Venoms; D012910:Snake Venoms; D014757:Viper Venoms; C003941:antihemorrhagic factor