High CTG repeat number in nodular thyroid tissue from a myotonic dystrophy patient.
CTG triplet expansion was studied in lymphocytes and thyroid tissue in a patient with myotonic dystrophy (DM) and associated thyroid nodular disease. An approximately 7 fold larger amplification was found in abnormal thyroid tissue compared to lymphocytes, suggesting that anomalies in the putative DM kinase gene might contribute to thyroid dysfunction.
Service d'Endocrinologie, Cliniques Universitaires St Luc, Brussels, Belgium.
C
C
Daumerie
N
N
Lannoy
J P
JP
Squifflet
G
G
Verellen
C
C
Verellen-Dumoulin
D000328:Adult; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D009030:Mosaicism; D009223:Myotonic Dystrophy / Q000150:complications / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D013959:Thyroid Diseases / Q000150:complications / Q000235:genetics; D013961:Thyroid Gland / Q000737:chemistry*
D004247:DNA