Excitatory transmitter neurotoxicity.
The major excitatory neurotransmitters in the mammalian CNS--glutamate (Glu) and acetylcholine (ACh)--have vitally important beneficial functions but also harbor treacherous neurotoxic potential which, as described in this review, can be expressed in several different ways.
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
J W
JW
Olney
D000818:Animals; D018846:Excitatory Amino Acids / Q000633:toxicity*; D006801:Humans; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D018377:Neurotransmitter Agents / Q000633:toxicity*; D017470:Receptors, Glutamate / Q000378:metabolism
D018846:Excitatory Amino Acids; D018377:Neurotransmitter Agents; D017470:Receptors, Glutamate