Effects of hypericum extract on the expression of serotonin receptors.
The influence of hypericum extract LI 160 on the expression of serotonin receptors was investigated using a neuroblastoma cell line to establish a model for the regulation of neurotransmitters by immunologically active compounds such as cytokines. The cells were incubated with hypericum extract LI 160 in kinetic form for 2, 4, 6, 8, and 10 hours, then washed. The serotonin receptor expression analysis was compared to that of a placebo control solution. The neuroblastoma cells showed a clearly reduced expression of the serotonin receptors under treatment with hypericum extract. First stimulation experiments with interleukin-1 (IL-1) and hypericum extract suggest that a further reduction of the serotonin receptors is possible when IL-1 is added.
Institut für Physiologische Chemie der Johannes-Gutenberg-Universität, Mainz, Germany.
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WE
Müller
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Rossol
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D020902:Hypericum; D007375:Interleukin-1 / Q000494:pharmacology; D009447:Neuroblastoma; D010569:Perylene / Q000031:analogs & derivatives* / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014966:Xanthenes / Q000494:pharmacology*
D000928:Antidepressive Agents; D007375:Interleukin-1; D010936:Plant Extracts; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014966:Xanthenes; D010569:Perylene; D011794:Quercetin