Magnetic resonance imaging and neuropathological findings in two patients with Creutzfeldt-Jakob disease.
We report 2 autopsy-proven patients with Creutzfeldt-Jakob disease (CJD) showing bilateral decreased signal intensity in the thalamus on T2-weighted images. On post-mortem examination, all affected areas showed the characteristic features of CJD, such as neuronal loss, gliosis, and status spongiosus. These findings are another distinctive MRI appearance in CJD.
Fourth Department of Internal Medicine, Toho University, Ohashi Hospital, Tokyo, Japan.
Y
Y
Iwasaki
K
K
Ikeda
N
N
Tagaya
M
M
Kinoshita
D000368:Aged; D001479:Basal Ganglia; D001921:Brain / Q000473:pathology*; D003342:Corpus Striatum / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013788:Thalamus / Q000473:pathology