[The use of 3rd-generation antacid preparations for the treatment of patients with nonulcerous dyspepsia and peptic ulcer complicated by reflux esophagitis].
In the present investigation on the treatment of patients with nonulcerous dyspepsia and peptic ulcer, hiatus hernia complicated with reflux esophagitis, a mechanism has been studied of the action of topalkan, a 3rd generation aluminium-magnesium antacid, that involves not only its antacid properties but in an even greater degree the availability of alginic acid in its formula which has antipeptic and protective effect with respect of the mucous membrane of the stomach and esophagus, and provides, together with the magnesium salts, a floating layer of the preparation in the stomach. In grave course of nonulcerous dyspepsia (preulcerous condition) and peptic ulcer complicated by reflux disease of the esophagus topalkan was used in combination with present-day antisecretory preparations pyrenzepine or H2-blockaders of histamine receptors capable of enhancing the antisecretory effect of topalkan as well as endowed with cytoprotective properties with respect of the mucous membrane of the stomach and duodenum promoting healing of erosions and healing and scarring of ulcerous defects.
I I
II
Degtiareva
A
A
Bogdanov
Z
Z
Khatib
N V
NV
Kharchenko
E V
EV
Lodianaia
O L
OL
Palladina
N D
ND
Opanasiuk
D000536:Aluminum Hydroxide; D000863:Antacids / Q000494:pharmacology / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy*; D004415:Dyspepsia / Q000188:drug therapy*; D004942:Esophagitis, Peptic / Q000188:drug therapy* / Q000209:etiology; D005745:Gastric Acidity Determination; D006551:Hernia, Hiatal / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008276:Magnesium Hydroxide; D013607:Tablets; D013997:Time Factors
D000863:Antacids; D004338:Drug Combinations; D013607:Tablets; C091591:topalkan; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide
Primenenie antatsidnykh preparatov III pokoleniia dlia lecheniia bol'nykh neiazvennoĭ dispepsieĭ i iazvennoĭ bolezn'iu, oslozhnennoĭ refliuks-ézofagitom.