Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation.
Aloe vera at doses of 100 and 300 mg/kg daily for 4 days blocked the wound healing suppression of hydrocortisone acetate up to 100% using the wound tensile strength assay. This response was because of the growth factors present in A. vera masking the wound healing inhibitors such as sterols and certain amino acids. The sterols showed good anti-inflammatory activity (-36%) in reducing the croton oil-induced ear swelling. This activity displayed a dose-response relationship.
Davis
R H
RH
Pennsylvania College of Podiatric Medicine, Philadelphia.
DiDonato
J J
JJ
Johnson
R W
RW
Stewart
C B
CB
D000504:Aloe; D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003436:Croton Oil; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004423:Ear / Q000293:injuries* / Q000503:physiopathology; D006854:Hydrocortisone / Q000494:pharmacology* / Q000627:therapeutic use; D007762:Labyrinthitis / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D053978:Pentacyclic Triterpenes; D010840:Phytosterols; D010946:Plants, Medicinal; D012855:Sitosterols / Q000494:pharmacology* / Q000627:therapeutic use; D013718:Tensile Strength / Q000187:drug effects*; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*; D000094042:Lupanes
D002784:Cholesterol; D003436:Croton Oil; D006854:Hydrocortisone; D053978:Pentacyclic Triterpenes; D010840:Phytosterols; D012855:Sitosterols; D014315:Triterpenes; C021273:campesterol; C025473:gamma-sitosterol; C010480:lupeol; D000094042:Lupanes