Promoter analysis meets pattern formation: transcriptional regulatory genes in sea urchin embryogenesis.
Analyses of spatial and temporal gene control mechanisms in the sea urchin embryo have identified several important trans-regulatory factors, including some that are related to known developmental control genes of the fly and mouse. Recent advances in gene perturbation technologies, including the use of antisense oligonucleotides to target mRNAs in early-stage embryos, as well as the injection of mRNAs into zygotes to express genes ectopically, have made it possible to test the functions of such factors directly.
Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033.
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D000818:Animals; D018507:Gene Expression Regulation, Developmental; D005809:Genes, Regulator; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics; D012617:Sea Urchins / Q000196:embryology* / Q000235:genetics*; D014158:Transcription, Genetic
D012333:RNA, Messenger