Model for cooperative control of positional information in Drosophila by bicoid and maternal hunchback.
The blastoderm of the fruit fly Drosophila melanogaster is unusually well suited for analysis of fundamental questions in animal development. One such question is how genes specify the positional information which determines the developmental pathways (fate) of cells at appropriate spatial locations. In this paper we propose a dynamical model of gene regulation which explicitly describes how positional information is used in the blastoderm. The model is applied to analyze important experimental findings on the dependence of cell fate on the concentration of the Bicoid morphogen. The model shows that positional information in the presumptive middle body is cooperatively determined by maternal products of the bicoid and hunchback genes.
Reinitz
J
J
Center for Medical Informatics, Yale Medical School, New Haven, Connecticut 06510.
Mjolsness
E
E
Sharp
D H
DH
D000818:Animals; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics; D018628:Gene Dosage; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins; D007301:Insect Hormones / Q000235:genetics*; D007605:Juvenile Hormones / Q000235:genetics*; D008957:Models, Genetic; D015534:Trans-Activators; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones; D007605:Juvenile Hormones; D015534:Trans-Activators; D014157:Transcription Factors; C056478:bcd protein, Drosophila; C061245:hb protein, Drosophila