Efficacy of a skeletal muscle-powered dynamic patch: Part 2. Right ventricular assistance.
The purpose of this study was to assess the feasibility of using a skeletal muscle-powered dynamic patch to assist the failing right ventricle. Seven adult mongrel dogs were used in the study. The proximal portion of the left latissimus dorsi muscle was harvested and reattached to the actuator to serve as a skeletal muscle energy convertor. The right ventricular free wall was fully excised and the dynamic patch was implanted under cardiopulmonary bypass. After weaning from cardiopulmonary bypass, the latissimus dorsi muscle was stimulated using a burst frequency of 33 Hz, a burst duration of 200 ms, and 1:2 synchronous mode stimulation with the native R wave. Latissimus dorsi muscle stimulation increased systolic aortic pressure (78 versus 91 mm Hg; p < 0.01), mean aortic pressure (56 versus 62 mm Hg; p < 0.05), aortic blood flow (0.73 versus 0.97 mL; p < 0.01), and systolic right ventricular pressure (41 versus 56 mm Hg; p < 0.01). The mean right atrial pressure decreased from 14 to 9.6 mm Hg (p < 0.01). Our results demonstrate that the use of a right ventricular dynamic patch powered by a skeletal muscle linear-type actuator can not only function as a right ventricular free wall substitute but also lead to the augmentation of right ventricular and global cardiac function.
Department of Surgery (1), Toyama Medical and Pharmaceutical University, Japan.
G
G
Watanabe
T
T
Misaki
M
M
Takahashi
H
H
Ohtake
Y
Y
Tsunezuka
M
M
Wada
Y
Y
Watanabe
D000818:Animals; D001011:Aorta / Q000502:physiology; D016275:Atrial Function; D001794:Blood Pressure; D018421:Cardiomyoplasty; D004285:Dogs; D004562:Electrocardiography; D006339:Heart Rate; D006353:Heart-Assist Devices; D011312:Pressure; D016278:Ventricular Function, Right; D017725:Ventricular Pressure