Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system.
The intrathecal synthesis of interleukin 10 (IL-10) was investigated in 120 paired cerebrospinal fluid (CSF) and serum specimens from patients with various inflammatory and non-inflammatory diseases of the central nervous system (CNS). IL-10 was not demonstrated in the sera, but detectable levels were found in the CSF from: patients with acute viral ("aseptic") meningitis, but only within 48-72 h of symptom onset; human immunodeficiency virus type 1 (HIV)-infected patients with HIV-related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary B cell lymphoma of the CNS, and a patient with encephalomeningeal sarcoidosis (in whom IL-10 was demonstrated in all CSF collected over a period of 6-months). In chronic meningeal infections/inflammations, IL-10 seems to be continuously produced within the CSF. Our findings suggest that IL-10, a cytokine which exerts many immunosuppressive actions, may play different immunomodulatory roles in CNS diseases; in particular, its intrathecal synthesis may explain why some infectious and inflammatory meningeal diseases may have slow development and chronic evolution.
Gallo
P
P
Institute of Neurology, University of Padua School of Medicine, Italy.
Sivieri
S
S
Rinaldi
L
L
Yan
X B
XB
Lolli
F
F
De Rossi
A
A
Tavolato
B
B
D015526:AIDS Dementia Complex / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D002493:Central Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology; D016543:Central Nervous System Neoplasms / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D002556:Cerebrospinal Fluid Proteins / Q000096:biosynthesis*; D002648:Child; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D015497:HIV-1; D006801:Humans; D007249:Inflammation; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D016919:Meningitis, Cryptococcal / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D011129:Polyradiculoneuropathy / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D012507:Sarcoidosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D013587:Syphilis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D016781:Toxoplasmosis, Cerebral / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D014777:Virus Diseases / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology
D002556:Cerebrospinal Fluid Proteins; D016753:Interleukin-10