Effect of S-carboxymethylcysteine lysine salt on mucociliary clearance in rabbits with secretory cell metaplasia.
A single intratracheal instillation of porcine pancreatic elastase (PPE, 100 U/Kg) induces in rabbits bronchial secretory cell metaplasia as well as emphysematous changes. The mucus hypersecretion and the marked reduction of ciliated cells matched by a high percentage of atypical cilia are responsible for the delayed mucociliary clearance in this model. S-Carboxymethylcysteine lysine salt (SCMC-LYS, 0.35 g/Kg b.w.), given per os daily for 10 days starting 2 days before elastase administration, significantly ameliorated the mucociliary clearance. The pharmacological treatment did not modify the degree of secretory cell metaplasia and the percentage of atypical cilia, or prevent the alveolar wall destruction. At TEM examination, the morphological aspects of secretion occurring in bronchial tree of PPE-treated animals were rarely visible in the PPE + SCMC-LYS treated group. The beneficial effect of SCMC-LYS on mucociliary clearance may be ascribed to an antisecretagogue effect of this drug through elastase inhibition and to a reduction of mucus viscosity.
Istituto di Patologia Generale, Università di Siena, Italy.
L
L
Daffonchio
M M
MM
De Santi
C
C
Gardi
G
G
Lungarella
C
C
Omini
D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D002233:Carbocysteine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005100:Expectorants / Q000627:therapeutic use*; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D008297:Male; D008679:Metaplasia / Q000139:chemically induced / Q000378:metabolism; D008954:Models, Biological; D009079:Mucociliary Clearance / Q000187:drug effects*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000633:toxicity; D011817:Rabbits
D005100:Expectorants; C034932:carbocysteine-lysine; D002233:Carbocysteine; D010196:Pancreatic Elastase