Adenoid cystic carcinoma of the uterine cervix with malignant stroma. An unusual variant of carcinosarcoma?
An 80-year-old woman developed vaginal bleeding caused by a large tumor of the cervix. Histologically, the tumor proved to be composed predominantly of adenoid cystic carcinoma focally associated with squamous cell carcinoma. Of special interest was the stroma, which displayed pleomorphism, multinucleated tumor giant cells, and numerous mitoses, justifying the designation of carcinosarcoma. A single similar reported case also regarded as a carcinosarcoma described a primary cervical neoplasm in a postmenopausal woman containing an admixture of heterologous sarcoma and conventional cervical adenocarcinoma, which focally demonstrated areas of adenoid cystic carcinoma.
Pennsylvania Hospital, Ayer Clinical Laboratories, Philadelphia, Pennsylvania 19107.
D T
DT
Manhoff
R
R
Schiffman
H M
HM
Haupt
D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry / Q000473:pathology*; D002296:Carcinosarcoma / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology*