Cerebral dysgenesis. An overview.
A significant portion of patients with neurodevelopmental abnormalities (mental retardation, learning disabilities, and so forth) have no definable cause for these problems. Mounting evidence suggests a substantial number of these idiopathic conditions have subtle abnormalities of brain development (cerebral dysgenesis) as the inherent pathophysiologic event. In this article the authors summarize normal and abnormal brain development, the diagnostic approach to idiopathic neurodevelopmental anomalies, and the new molecular genetic insights into the underlying causes of brain malformations.
Department of Pediatrics, Meyer Rehabilitation Institute, University of Nebraska Medical Center, Omaha.
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GB
Schaefer
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Sheth
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JB
Bodensteiner
D001921:Brain / Q000002:abnormalities* / Q000196:embryology; D003952:Diagnostic Imaging; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology; D008487:Medical History Taking / Q000379:methods; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000209:etiology; D013723:Teratogens
D013723:Teratogens