[Chronic fatigue syndrome--a controlled cross-sectional study].
Twenty-one patients fulfilling the Center for Disease Control criteria for chronic fatigue syndrome (CFS) were examined in a controlled study. Viral antibodies and tests evaluating the immune system were investigated in the patients and in a control group of 21 sex- and age-matched individuals. Production in vitro of the predominantly T-cell-derived cytokines interleukin-2 and interferon-gamma was significantly higher in patients with CFS compared the control group. Furthermore, the serum concentrations of IgA and IgE were significantly lower in patients with CFS; however, the values were within the normal reference range. All other variables were similar in the two groups. This study does not suggest a clearly disordered immune system or a chronic viral infection as a major pathogenetic factor in CFS. Longitudinal studies of immunological and virological parameters in CFS are warranted as are studies on patients that are severely handicapped.
Rasmussen
A K
AK
Medicinsk afdeling TTA og infektionsmedicinsk afdeling M, Rigshospitalet, København.
Nielsen
H
H
Andersen
V
V
Barington
T
T
Bendtzen
K
K
Hansen
M B
MB
Nielsen
L
L
Pedersen
B K
BK
Wiik
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D003430:Cross-Sectional Studies; D003718:Denmark; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D001323:Autoantibodies; D007136:Immunoglobulins
Kronisk traethedssyndrom--et kontrolleret tvoersnitsstudie.