The identification of a Caenorhabditis elegans homolog of p34cdc2 kinase.
We have identified a Caenorhabditis elegans homolog of p34cdc2 kinase. The C. elegans homolog, ncc-1, is approximately 60% identical to p34cdc2 of Homo sapiens. When expressed from a constitutive yeast promoter, ncc-1 is capable of complementing a conditional lethal mutation in the CDC28 gene of Saccharomyces cerevisiae, indicating that this C. elegans homolog can properly regulate the cell cycle.
Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125.
H
H
Mori
R E
RE
Palmer
P W
PW
Sternberg
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016203:CDC2 Protein Kinase / Q000235:genetics*; D017173:Caenorhabditis elegans / Q000201:enzymology*; D002453:Cell Cycle; D003001:Cloning, Molecular; D017238:Genes, Helminth; D005816:Genetic Complementation Test; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D016203:CDC2 Protein Kinase