[The effects of aging on renal function test].
To determine the effect of aging on renal functions, I measured the concentration of blood urea nitrogen (BUN), serum uric acid and serum creatinine. Seven hundred and forty-six healthy women who underwent health screening were divided into 4 groups, 28-39 years old (thirties), 40-49 (forties), 50-59 (fifties) and 60-69 (sixties). I found no significant differences between groups of thirties and forties in the BUN and serum uric acid concentrations. The BUN and uric acid concentrations in groups of fifties and sixties were significantly higher than those in groups of thirties and forties (p < 0.01). On the other hand, no significant differences were found among the four groups in the serum creatinine level. In conclusion, women over the age 50 had significantly higher BUN and serum uric acid values. On the other hand, the serum creatinine concentration remained constant in the thirties to sixties groups. Between the age of 45 and 54, the serum uric acid level in postmenopausal women was significantly higher than that in women prior to the menopause. Considering that the mean age of the menopause is 50 years, the results suggested that female sex hormones had some effect on renal function tests. But further examination, for example comparing the levels of renal function tests in men and women is needed to confirm the effects of female sex hormones.
Department of Internal Medicine, Shinbashi Hospital, Gunma.
K
K
Yoshida
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D008593:Menopause / Q000378:metabolism; D008875:Middle Aged; D014527:Uric Acid
D014527:Uric Acid; D003404:Creatinine