[The effect of emotional-painful stress, hypoxia, and adaptation to it on the activity of enzymes for metabolizing glutathione and concentration of glutathione in rat organs].
The stress activates glutathione peroxidase in the heart, liver, and kidney, glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the liver; the activity of glutathione reductase and the content of reduced glutathione were unchanged. Two-four-minute hypercapnic hypoxia unchanged the activity of glutathione metabolic enzymes. The activity of the above enzymes decreases in some organs at the death caused by 2-15-minute hypoxia. Long-term intermittent adaptation to hypobaric hypoxia lowers the activity of glutathione peroxidase, -transferase and -reductase. The biological value of the two types of enzymatic responses may be different: stress-induced activation of glutathione metabolic enzymes can enhance resistance to stress and xenobiotics; however, their inhibition during hypoxic adaptation may produce the opposite effect.
L S
LS
Kolesnichenko
V I
VI
Kulinskiĭ
M V
MV
Ias'ko
E N
EN
Ekimov
L M
LM
Stanevich
E F
EF
Glushkova
S B
SB
Belogorov
G T
GT
Filippova
D000222:Adaptation, Physiological; D000818:Animals; D004789:Enzyme Activation; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D000860:Hypoxia / Q000201:enzymology* / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D010146:Pain / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D013315:Stress, Psychological / Q000201:enzymology* / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005978:Glutathione
Vliianie émotsional'no-bolevogo stressa, gipoksii i adaptatsii k neĭ na aktivnost' fermentov metabolizma glutationa i kontsentratsiiu glutationa v organakh krys.