Intermediate lymphocytic lymphoma with both t(14;19)(q32.3;q13.1) and t(3;22)(q27;q11.2).
Chromosome translocations involving various chromosomes sites, including the sites of immunoglobulin loci (14q32,2p12,22q11) represent recurrent aberration in non-Hodgkin lymphoma (NHL). We report a novel case of intermediate lymphocytic lymphoma (ILL) with both t(14;19)(q32.3;q13.1) and t(3;22)(q27;q11.2). The t(14;19)(q32.3;q13.1) and t(3;22) (q27;q11.2) may represent reciprocal recombinations between immunoglobulin (Ig) H chain gene (14q32.3) and bcl-3(19q13.1) and between Ig lambda chain gene (22q11.2) and bcl-6 (3q27), respectively.
Osaka University medical School, Department of Medicine III, Japan.
M
M
Nakagawa
H
H
Sugiyama
H
H
Ogawa
S
S
Tone
H
H
Morishita
H
H
Ikeda
K
K
Aozasa
M
M
Taniwaki
T
T
Abe
T
T
Kishimoto
D000368:Aged; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D002892:Chromosomes, Human, Pair 22; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic