Nuclear pores in the apoptotic cell.
During apoptosis, nuclear pores undergo strong modifications, which are described here in five different apoptotic models. Conventional electron microscopy, supported by freeze-fracture analysis, showed a constant migration of nuclear pores towards the diffuse chromatin areas. In contrast, dense chromatin areas appear pore-free and are frequently surrounded by strongly dilated cisternae. A possible functional significance of this pore behaviour during apoptosis is discussed.
Istituto di Morfologia Umana Normale, Università di Chieti, Bologna.
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Falcieri
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Gobbi
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Cataldi
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Zamai
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Faenza
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Vitale
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002460:Cell Line; D005614:Freeze Fracturing; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology; D007951:Leukemia, Myeloid / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000473:pathology / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron / Q000379:methods; D009685:Nuclear Envelope / Q000648:ultrastructure*; D013950:Thymus Gland / Q000473:pathology / Q000648:ultrastructure; D014407:Tumor Cells, Cultured