[Is sarcoidosis a chronic persistent infection?].
The study carried out with the use of microbiological diagnostic methods has revealed that in 67% of cases specimens obtained from sarcoidosis patients for analysis contain different forms of mycobacteria (typical Mycobacterium tuberculosis and granular forms of mycobacteria). The content of typical and granular forms of mycobacteria detected in diagnostic specimens has been shown to differ, depending on the clinical form of sarcoidosis: as a rule, in cases of the sluggish course of sarcoidosis granular forms of mycobacteria are detected, while during the exacerbation of the disease and in cases of the acute course of newly diagnosed sarcoidosis the proportion of typical M.tuberculosis increases. To verify M.tuberculosis with greater certainty, two highly sensitive and specific amplification test systems have been developed on the basis of polymerase chain reaction. In this article the goals of microbiological and molecular genetic investigations which may jointly give direct proofs of the etiological importance of mycobacteria in sarcoidosis are considered and discussed; sarcoidosis may probably be regarded as chronic persistence infection.
Khomenko
A G
AG
Golyshevskaia
V I
VI
Shaginian
I A
IA
Safonova
S G
SG
Nesterenko
L N
LN
Grishina
T D
TD
Gintsburg
A L
AL
Prozorovskiĭ
S V
SV
D000818:Animals; D001483:Base Sequence; D002908:Chronic Disease; D017931:DNA Primers; D004269:DNA, Bacterial / Q000302:isolation & purification; D006168:Guinea Pigs; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D016133:Polymerase Chain Reaction / Q000379:methods; D012507:Sarcoidosis / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D014774:Virulence
D017931:DNA Primers; D004269:DNA, Bacterial
Iavliaetsia li sarkoidoz khronicheskoĭ persistiruiushcheĭ infektsieĭ?