A comparison of low vs standard dose intramuscularly administered hepatitis B vaccine.
In a randomised, controlled, single-blind trial we compared different doses of a yeast-derived recombinant hepatitis B vaccine: a low dose intramuscular (i.m.) regimen (using 2 micrograms at first followed by 1 microgram each at 1, 2 and 6 months) with the standard dose (10 micrograms each at 0, 1 and 6 months) for post vaccination anti-HBs seropositivity. At the end of 7 months, only 78% of volunteers on the low dose (n = 77) tested positive for anti-HBs whereas 100% of volunteers on the standard dose (n = 43) were seropositive. Therefore, low dose regimen is not satisfactory for primary HBV vaccination.
Department of Medicine, Christian Medical College and Hospital, Vellore.
E A
EA
Venkatesan
D
D
Mathai
B U
BU
Samuel
T J
TJ
John
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines