[The late sequelae from the body exposure of healthy animals to a superlow dose of nitrosomethylurea].
Time-related changes in essential internal organs (spleen, thymus, liver, kidney, and lung) and peripheral blood cells (leucocytes and large granular lymphocytes) were studied in healthy mice for 50 days after a single injection of 10(-15) M water solution of nitrosomethylurea. Mass and cellularity fluctuations were induced. The longest fluctuation period was 45 days (for the lung) and the shortest one was 15-20 days (for the liver and blood cells). Possible consequences of treatment with extra low doses of the biologically active drug for the organism are discussed.
Khaleev
D V
DV
Potapov
Iu N
IuN
Krutova
T V
TV
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006098:Granulocytes / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D008770:Methylnitrosourea / Q000008:administration & dosage* / Q000633:toxicity; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors
D008770:Methylnitrosourea
Otdalennye posledstviia vozdeĭstviia na organizm zdorovykh zhivotnykh sverkhmaloĭ dozy nitrozometilmocheviny.