Risk factors for the development of non-insulin-dependent diabetes mellitus (NIDDM) in Japan.
Follow-up studies of subjects with impaired glucose tolerance in Japan have shown that a higher level of blood glucose is a major predictor of the subsequent development of non-insulin-dependent diabetes mellitus (NIDDM). In addition, subjects with a lower insulin response to glucose show a higher risk for the development of NIDDM. In fact, most of the subjects who later develop diabetes show a lower insulin response to glucose at the initial examination. Moreover, obesity is generally associated with a higher risk of developing NIDDM. We conclude that low insulin secretion forms an important basis and obesity plays a precipitating role among low-insulin responders in the pathogenesis of the majority of NIDDM patients in Japan.
Third Department of Internal Medicine, University of Tokyo, Japan.
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Kadowaki
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Yoshinaga
D001786:Blood Glucose / Q000032:analysis; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D005500:Follow-Up Studies; D005947:Glucose / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007564:Japan / Q000453:epidemiology; D009765:Obesity / Q000150:complications; D011237:Predictive Value of Tests; D012307:Risk Factors
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose