Frequency of anti-nuclear antibodies in multiple sclerosis.
We found anti-nuclear antibodies (ANA) in 26.7% of 150 relapsing-remitting and in 30.4% of 23 chronic progressive definite multiple sclerosis (MS) patients by retrospective chart review. These patients did not have systemic lupus erythematosus. Since ANA are not pathogenically relevant in MS, they are false-positive, and likely reflect systemic immune dysregulation in MS.
Barned
S
S
Department of Neurology, University of Rochester Medical Center, NY.
Goodman
A D
AD
Mattson
D H
DH
D000328:Adult; D000367:Age Factors; D000974:Antibodies, Antinuclear / Q000097:blood*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D012189:Retrospective Studies; D012727:Sex Characteristics; D012737:Sex Factors
D000974:Antibodies, Antinuclear