Avian cellular homolog of the qin oncogene.
We have isolated chicken cDNA clones of the c-qin gene, the cellular counterpart of the v-qin (Chinese for "avian") oncogene of avian sarcoma virus 31. There are several differences between the cellular and the viral qin sequences: (i) two nonconservative amino acid substitutions in the Qin coding region; (ii) a truncation in the carboxyl terminus of the viral protein due to a premature stop codon; (iii) a partial Gag sequence fused to the amino terminus of viral Qin; and (iv) eight cell-coded amino acids which link the cellular Qin coding domain to the viral Gag domain. We have also characterized the expression pattern of c-qin in chicken embryos by in situ hybridization and by Northern blot analysis. c-qin is abundantly expressed in the developing brain, and this expression is restricted to the telencephalon of early embryos.
Scripps Research Institute, La Jolla, CA 92037.
H W
HW
Chang
J
J
Li
D
D
Kretzschmar
P K
PK
Vogt
D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D002642:Chick Embryo / Q000033:anatomy & histology; D002645:Chickens / Q000235:genetics*; D003001:Cloning, Molecular; D015342:DNA Probes; D018076:DNA, Complementary / Q000235:genetics; D051858:Forkhead Transcription Factors; D018628:Gene Dosage; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D015513:Oncogene Proteins; D009857:Oncogenes / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013687:Telencephalon / Q000033:anatomy & histology / Q000737:chemistry; D014018:Tissue Distribution; D014764:Viral Proteins
D030161:Avian Proteins; D015342:DNA Probes; D018076:DNA, Complementary; D051858:Forkhead Transcription Factors; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D014764:Viral Proteins; C490425:v-qin protein, Avian sarcoma virus 31