[Chronic fatigue syndrome--a controlled cross-sectional study].
Twenty-one patients fulfilling the Center for Disease Control criteria for chronic fatigue syndrome (CFS) were examined in a controlled study. Viral antibodies and tests evaluating the immune system were investigated in the patients and in a control group of 21 sex- and age-matched individuals. Production in vitro of the predominantly T-cell-derived cytokines interleukin-2 and interferon-gamma was significantly higher in patients with CFS compared the control group. Furthermore, the serum concentrations of IgA and IgE were significantly lower in patients with CFS; however, the values were within the normal reference range. All other variables were similar in the two groups. This study does not suggest a clearly disordered immune system or a chronic viral infection as a major pathogenetic factor in CFS. Longitudinal studies of immunological and virological parameters in CFS are warranted as are studies on patients that are severely handicapped.
Medicinsk afdeling TTA og infektionsmedicinsk afdeling M, Rigshospitalet, København.
A K
AK
Rasmussen
H
H
Nielsen
V
V
Andersen
T
T
Barington
K
K
Bendtzen
M B
MB
Hansen
L
L
Nielsen
B K
BK
Pedersen
A
A
Wiik
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D003430:Cross-Sectional Studies; D003718:Denmark; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D001323:Autoantibodies; D007136:Immunoglobulins
Kronisk traethedssyndrom--et kontrolleret tvoersnitsstudie.