Radial glia in the neocortex of adult rats: effects of neonatal brain injury.
Microgyria can be induced in otherwise normal rat neocortex by a freezing injury to the cortical plate before the completion of neuronal migration. We had previously reported radial glial like-immunoreactive fibers in the area of the microgyria in 32-day-old rats. Here we demonstrate that these glial fibers, which are immunoreactive to Rat-401, vimentin, and glial fibrillary acidic protein (GFAP) antibodies, are seen in adult rats. The appearance of these fibers is hypothesized to result from the release of a trophic factor during the recovery from neonatal injury which acts to either (1) halt the transformation of radial glia to astrocytes and/or dedifferentiate already committed astrocytes, (2) create a hybrid cell, or (3) induce increased proliferation of glia.
Dyslexia Research Laboratory, Beth Israel Hospital, Boston, MA 02215.
G D
GD
Rosen
G F
GF
Sherman
A M
AM
Galaburda
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal; D001930:Brain Injuries / Q000473:pathology*; D002540:Cerebral Cortex / Q000254:growth & development / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007150:Immunohistochemistry; D009336:Necrosis; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology*; D009457:Neuroglia / Q000473:pathology* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014746:Vimentin / Q000032:analysis
D000911:Antibodies, Monoclonal; D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin