Occlusion of the retinal vasculature after trabeculectomy with mitomycin C.
A 45-year-old male underwent a trabeculectomy with mitomycin C for a secondary glaucoma after complicated cataract surgery. Because of early bleb failure a needling procedure with subconjunctival injection of mitomycin C was performed. Five days postoperatively the patient developed an occlusion of both the arterial and venous retinal vasculature. A relation between the diffusion of mitomycin C into the vitreous cavity and the development of retinal toxicity is suggested.
Department of Ophthalmology, University of Amsterdam, The Netherlands.
R M
RM
Nuyts
H A
HA
Van Diemen
E L
EL
Greve
D002387:Cataract Extraction / Q000009:adverse effects; D005901:Glaucoma / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D006801:Humans; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects*; D015356:Retinal Artery Occlusion / Q000139:chemically induced* / Q000473:pathology; D012170:Retinal Vein Occlusion / Q000139:chemically induced* / Q000473:pathology; D014130:Trabeculectomy / Q000009:adverse effects*
D016685:Mitomycin