Comparative kinetic study of the binding between 2,3,7,8-tetrachlorodibenzo-p-dioxin and related ligands with the hepatic Ah receptors from several rodent species.
Kinetic analysis of the time course of association of [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin with hepatic cytosol from five rodent species gave additional evidence for differences in the properties of the Ah receptor ligand binding subunit between species. A parallel study of the association of six tritiated polychlorinated dibenzo-p-dioxins and dibenzofurans with hepatic Ah receptor from Wistar rat and C57BL/6 mouse showed that their rank order for kinetic affinity did not correlate with the rank ordering of their toxic potency and may vary according to the source of the Ah receptor.
Department of Chemistry and Biochemistry, University of Guelph, Ontario, Canada.
J S
JS
Nakai
M J
MJ
Winhall
N J
NJ
Bunce
D000818:Animals; D006224:Cricetinae; D003600:Cytosol / Q000378:metabolism; D005849:Gerbillinae; D006168:Guinea Pigs; D006358:Hot Temperature; D008024:Ligands; D008099:Liver / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D000072317:Polychlorinated Dibenzodioxins / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*; D013045:Species Specificity
D008024:Ligands; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon