Hydrophobic response of Escherichia coli exposed to subminimal inhibitory concentrations of ampicillin and chloramphenicol.
Hydrophobicity generally increased as the cells passed from lag to exponential phases of growth and declined in the stationary phase. All concentrations of ampicillin used increased hydrophobicity, although still subject to effect of phase of growth. Chloramphenicol caused decline in hydrophobicity. Combination of the two antibiotics gave a concentration dependent balance of the two forces observed. Protein synthesis inhibition may render cells resistant to phagocytic uptake by lowering surface hydrophobicity. This phenomenon is probably involved in cases of therapeutic failures, persistent of recurrent infections. This is a further indication of the undesirability of antibiotic abuse.
Department of Pharmaceutical Microbiology and Clinical Pharmacy, College of Medicine, University of Ibadan, Nigeria.
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Salami
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Bassey
D000667:Ampicillin / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004363:Drug Utilization; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D008826:Microbial Sensitivity Tests; D010586:Phagocytes / Q000187:drug effects; D012008:Recurrence; D012651:Self Medication; D017211:Treatment Failure
D002701:Chloramphenicol; D000667:Ampicillin