Abnormal sympathetic innervation of the heart in a patient with myotonic dystrophy detected with I-123 MIBG cardiac SPECT.
Iodine-123 MIBG is a norepinephrine analog which can be used to image the sympathetic innervation of the heart. The authors report a patient with myotonic dystrophy whose I-123 MIBG SPECT revealed accelerated washout of I-123 MIBG from infero-posterior and a part of lateral wall, although Tl-201 SPECT showed no abnormal finding. The authors conclude that I-123 MIBG can be more sensitive in detecting the cardiac abnormality than Tl-201 SPECT in this disease.
Department of Radiology, Saitama Medical Center, Saitama Medical School, Japan.
K
K
Machida
N
N
Honda
T
T
Mamiya
T
T
Takahashi
T
T
Kamano
A
A
Kashimada
Y
Y
Inoue
M
M
Kinoshita
D019797:3-Iodobenzylguanidine; D001341:Autonomic Nervous System / Q000000981:diagnostic imaging; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation*; D006327:Heart Block / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000150:complications*; D013565:Sympatholytics; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013565:Sympatholytics; D013794:Thallium Radioisotopes; D019797:3-Iodobenzylguanidine