[Protective effect of putrescine on oleic acid-induced respiratory distress syndrome (RDS)].
The effect of putrescine on oleic acid-induced RDS were studied in rat, it was found that preadministration of putrescine to rat with RDS significantly improved its hypoxemia, pulmonary edema and histologic injury; inhibited the leakage of protein from plasma; lowered increase of pulmonary lipid peroxidation products (malondialdehde, MDA). The result suggests that putrescine could have significant potential for clinical treatment of acute pulmonary injury.
Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University.
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Zhao
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Liu
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Fu
D000818:Animals; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D019301:Oleic Acid; D009829:Oleic Acids; D009929:Organ Size / Q000187:drug effects; D011700:Putrescine / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000517:prevention & control*
D009829:Oleic Acids; D019301:Oleic Acid; D008315:Malondialdehyde; D011700:Putrescine