[Morphofunctional features of the immunocompetent system of harmoniously developed large newborns].
Immune system of 70 large newborns was compared to 50 newborns of an average weight. Large newborns showed domination of lymphopoiesis over epithelioreticulopoiesis in the thymus against the background of the cortical thymocytes apoptosis delay and decrease of the thymus hormonal activity; enhancement of myelopoiesis, T and B-zone hyperplasia in the peripheral organs, decrease of the immunoglobulins production, alteration of T and B-lymphocyte maturation. Inadequate response to the antigenic stimulus is characteristic for large newborns this resulting in a higher susceptibility of these children to bacterial and viral infections and tendency to the allergic conditions during first 9 years of their life.
Iakovtsova
A F
AF
Sorokina
I V
IV
D017209:Apoptosis / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology; D001724:Birth Weight / Q000276:immunology*; D016922:Cellular Senescence / Q000276:immunology; D005314:Embryonic and Fetal Development / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000473:pathology / Q000502:physiology*; D007121:Immunocompetence / Q000502:physiology*; D007231:Infant, Newborn / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
Morfofunktsional'nye osobennosti immunokompetentnoĭ sistemy garmonichno razvitykh krupnykh novorozdennykh.