[An immunohistochemical study of cornea and adjacent bulbar conjunctiva in Mooren's ulcer].
The specimens of the corneal lesions and their adjacent bulbar conjunctivas taken from 14 cases with Mooren's ulcers were studied by immunohistochemical techniques to investigate the expression of HLA-DR antigen and the subgroups of lymphocytes. It is discovered that there is an aberrant expression of HLA-DR antigen in a large amount of keratoconjunctival epithelial cells and stromal keratocytes and simultaneously, the CD4/CD8 ratio is significantly higher than that of the normal control group. The results suggest that the aberrant expression of MHC-II antigen in the resident cells at the peripheral cornea and its adjacent conjunctiva and a raised local TH/TS ratio leading to an excessive autoimmune reactivity be possibly the direct cause of the pathogenesis of the Mooren's ulcer.
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou.
Z
Z
Wang
J Q
JQ
Chen
H L
HL
Zheng
D000328:Adult; D016516:CD4-CD8 Ratio; D003228:Conjunctiva / Q000276:immunology*; D003315:Cornea / Q000276:immunology*; D003320:Corneal Ulcer / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets
D006684:HLA-DR Antigens