An echocardiographic and electrocardiographic study of cardiovascular function in hypothyroid dogs.
Echocardiograms and ECG were obtained for 11 hypothyroid dogs before and after levothyroxine supplementation (0.022 mg/kg of body weight, q 12 h for 64 +/- 12 days). Evidence of impaired left ventricular function was found in the dogs before treatment. A significant decrease in shortening fraction and velocity of circumferential fiber shortening, increase in left ventricular end-systolic diameter, and prolongation of preejection period was noted when comparing measurements before and after levothyroxine supplementation. Amplitude of the P and R waves was significantly higher after treatment than before. It was concluded that changes in cardiac function can be reversed in hypothyroid dogs.
Panciera
D L
DL
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
D000818:Animals; D002319:Cardiovascular System / Q000503:physiopathology*; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000662:veterinary
D013974:Thyroxine