[Streptococcal group A carriage: new data on the characteristics of the biology of the causative agent and of the immune response of the host].
Carriership of group A streptococcus (A-STR) was registered with significantly greater frequency among children of preschool and early school age (29.8%) than among adults (4.0%). Cultures of A-STR isolated from carriers were characterized by their low capacity for secreting erythrogenic toxin of type A (ET-A), lipoteichoic acid and by lower content of surface proteins than those isolated from tonsillitis and scarlet fever patients. Highly hydrophobic strains of A-STR prevailed in long-time carriers and patients. Elevated immunological characteristics for group-specific polysaccharide A and ET-A were more frequently detected in children than in adults, which correlated with frequency of A-STR carriership in these groups and the capacity of the infective agent to produce ET-A. Some specific features in the character of humoral immune response in carriers, manifested mainly by defects of local immunity (a low level of SIgA to polysaccharide A), were established.
Briko
N I
NI
Dmitrieva
N F
NF
Eshchina
A S
AS
Dynga
L O
LO
Shevelev
B I
BI
Sobolev
V I
VI
Vylegzhanina
E S
ES
Kuksiuk
P P
PP
D000328:Adult; D000917:Antibody Formation; D001782:Blood Donors; D002353:Carrier State / Q000276:immunology / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008889:Military Personnel; D014066:Palatine Tonsil / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D012426:Russia; D013290:Streptococcal Infections / Q000276:immunology / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D014505:Urban Population
Nositel'stvo streptokokka gruppy A: novye dannye po kharakteristike biologii vozbuditelia i immunnogo otveta khoziaina.