[Effectiveness of new quinolones in experimental aerogenic plague infection of albino mice].
It was shown that unlike nalidixic acid the 3rd generation quinolones i.e. the nitrogen-containing quinolones (LIB-71 and LIB-80) and the fluorine-containing quinolones (pefloxacin and ciprofloxacin) were highly efficient in the prophylaxis and treatment of experimental plague in albino mice infected via the plague microbe inhalation. By the ED50 the efficacy of pefloxacin was 25-30 times higher than that of nalidixic acid and 60-90 times higher than that of ciprofloxacin. The fluorine-containing quinolones proved to be more active than the nitrogen-containing ones.
A I
AI
Shcherbaniuk
N V
NV
Lozovoĭ
I V
IV
Kasatkina
V V
VV
Pasiukov
D042462:4-Quinolones; D000280:Administration, Inhalation; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D009268:Nalidixic Acid / Q000627:therapeutic use*; D015366:Pefloxacin / Q000494:pharmacology; D010930:Plague / Q000188:drug therapy*; D015363:Quinolones / Q000627:therapeutic use
D042462:4-Quinolones; D000890:Anti-Infective Agents; C091869:LIB 71; C091870:LIB 80; D015363:Quinolones; D015366:Pefloxacin; D009268:Nalidixic Acid; D002939:Ciprofloxacin
Effektivnost' novykh khinolonov pri aérogennoĭ éksperimental'noĭ chume belykh mysheĭ.