[In vitro study of clastogenic properties of nitrites and nitrates].
In vitro culture of peripheral blood lymphocytes has been used to evaluate the ability of nitrates (NaNO3) and nitrites (NaNO2) to produce chromosome aberrations in mammalian cells. Whereas treatment with NaNO3 did not increase the spontaneous yield of aberrations, exposure to high doses of NaNO2 resulted in an low increase of micronucleated cells and of chromatid gaps.
Balimandawa
M
M
Unité de Tératogenèse et Mutagenèse, Université Catholique de Louvain, UCL 72.37, Bruxelles.
de Meester
C
C
Léonard
A
A
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000473:pathology*; D009566:Nitrates / Q000494:pharmacology*; D009573:Nitrites / Q000494:pharmacology*
D009566:Nitrates; D009573:Nitrites
Etude, in vitro, des propriétés clastogènes des nitrites et des nitrates.