A comparative magnetic resonance imaging study of the corpus callosum in neurologically normal children and children with spastic diplegia.
To determine the extent of brain damage in children with spastic diplegia, we analyzed the true midsagittal magnetic resonance imaging findings for the corpus callosum in 43 children with spastic diplegia and in 69 neurologically normal children. In the normal children, the thicknesses of the genu, midbody, splenium and the entire corpus callosum were found to increase with age, while the ratios of the thickness of the splenium and of the midbody to the length were constant, regardless of age. Both ratios were significantly reduced in diplegic children and the ratio for the splenium was highly correlated with the extent of motor impairment. Assessment of the morphometric changes in the corpus callosum using magnetic resonance imaging may contribute to the determination of the extent of brain damage in diplegic children.
Department of Pediatrics, Chiba University School of Medicine, Japan.
M
M
Iai
Y
Y
Tanabe
M
M
Goto
K
K
Sugita
H
H
Niimi
D000293:Adolescent; D001284:Atrophy; D002547:Cerebral Palsy / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male