MIC2R: a transcribed MIC2-related sequence associated with a CpG island in the human pseudoautosomal region.
Sequences related to exons 1, 4 and 5 of the human pseudoautosomal gene MIC2 have been detected on the X and Y chromosomes of humans and other primate species. Isolation of these sequences has defined a new transcribed locus, MIC2R (MIC2-related) which is associated with the second most proximal CpG-rich island in the human pseudoautosomal region. Genomic sequences from the MIC2R locus show that it is composed of a single sequence related to exon 1 and at least four tandem copies of sequences related to exons 4 and 5 of MIC2. Comparison of the four exon 4- and 5-related sequences suggest that they are the result of sequential duplication of a 2.8 kb region during evolution. Transcripts from the MIC2R locus have been detected in all tissues analysed and a number of different transcripts appear to be generated by alternative RNA splicing. However, as none of the transcripts analysed to date contain a significant open reading frame, the function of the MIC2R locus remains unknown.
Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia.
M J
MJ
Smith
P N
PN
Goodfellow
D000071443:12E7 Antigen; D017398:Alternative Splicing; D000595:Amino Acid Sequence; D015703:Antigens, CD; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005091:Exons; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D008745:Methylation; D008969:Molecular Sequence Data; D005810:Multigene Family; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D014960:X Chromosome; D014998:Y Chromosome
D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D009838:Oligodeoxyribonucleotides; D004247:DNA