Phosphatidylethanol formation and degradation in brains of acutely and repeatedly ethanol-treated rats.
The formation of the abnormal phospholipid phosphatidylethanol (PEth) was studied in hippocampus, cerebellum and cerebrum of rat brain after intraperitoneal ethanol administration. Prior to analysis by high performance thin layer chromatography PEth was purified. After one injection, PEth levels reached a maximum after 2 h and remained detectable for 14-24 h in all three regions. Repeated injections led to additional accumulation. Maximum in vivo levels of 30-50 nmol/g wet wt. were reached.
Department of Psychiatry and Neurochemistry, Lund University, Sweden.
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Lundqvist
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Aradottir
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Alling
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MC
Boyano-Adanez
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Gustavsson
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002855:Chromatography, Thin Layer; D000431:Ethanol / Q000494:pharmacology*; D020404:Glycerophospholipids; D008297:Male; D008970:Molecular Weight; D010168:Palmitates / Q000378:metabolism; D010712:Phosphatidic Acids / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014407:Tumor Cells, Cultured
D020404:Glycerophospholipids; D010168:Palmitates; D010712:Phosphatidic Acids; C051521:phosphatidylethanol; D000431:Ethanol