Room temperature stable perfluorocarbon emulsions with acceptable half-lives in the reticuloendothelial system.
Prolonged room temperature stability (i.e. zero particle growth) can be achieved for concentrated emulsions of perflubron (perfluorooctyl bromide) or perfluorodecalin via addition of a secondary high molecular weight, lipophilic fluorocarbon component. Due to their enhanced lipophilic character, the secondary fluorocarbon components have acceptable half-lives in the organs of the reticuloendothelial system.
Weers
J G
JG
Alliance Pharmaceutical Corp., San Diego, California.
Liu
J
J
Fields
T
T
Resch
P
P
Cavin
J
J
Arlauskas
R A
RA
D000818:Animals; D004355:Drug Stability; D004655:Emulsions; D005260:Female; D005466:Fluorocarbons / Q000493:pharmacokinetics*; D006207:Half-Life; D008297:Male; D012157:Mononuclear Phagocyte System / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D004655:Emulsions; D005466:Fluorocarbons