Age-specific prevalence of antibodies to hepatitis A and E viruses in Pune, India, 1982 and 1992.
The age-specific seroprevalence of antibody to hepatitis A virus (HAV) and antibody to hepatitis E virus (HEV) were studied in persons in Pune, India, where both viruses are endemic. The data showed that HAV infected the majority of persons by age 3 years and virtually 100% by late childhood. In contrast, infection with HEV was rare in children and did not reach peak prevalence (33%-40%) until early adulthood. The reason for the differences in infection rates between HAV and HEV is not known. Age-specific antibody patterns in serum samples obtained 10 years apart show that neither HAV nor HEV has diminished in medical importance in this Indian community.
National Institute of Virology, Indian Council of Medical Research, Pune.
V A
VA
Arankalle
S A
SA
Tsarev
M S
MS
Chadha
D W
DW
Alling
S U
SU
Emerson
K
K
Banerjee
R H
RH
Purcell
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology* / Q000276:immunology; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000097:blood*; D016751:Hepatitis E / Q000453:epidemiology* / Q000276:immunology; D016752:Hepatitis E virus / Q000276:immunology*; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D013997:Time Factors
D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies