Supraventricular tachycardia in a patient receiving ECT, clozapine, and caffeine.
A patient receiving electroconvulsive therapy (ECT), clozapine, and intravenous caffeine sodium benzoate developed supraventricular tachycardia. This was rapidly treated with intravenous verapamil. Subsequent maintenance ECT given without caffeine was well tolerated. We believe the combination of clozapine and caffeine at the time of ECT was responsible for the arrhythmia.
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston 29425.
M D
MD
Beale
J T
JT
Pritchett
C H
CH
Kellner
D000341:Affective Disorders, Psychotic / Q000523:psychology / Q000628:therapy*; D000368:Aged; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects*; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy*; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D012008:Recurrence; D013617:Tachycardia, Supraventricular / Q000139:chemically induced* / Q000188:drug therapy
D002110:Caffeine; D003024:Clozapine