Thrombolysis in pulmonary embolism: an adolescent with protein S deficiency.
Because of the low incidence of pulmonary embolism in children, the therapeutic approach is extrapolated from guidelines for adults. An adolescent boy with a massive pulmonary embolism associated with protein S deficiency was cared for successfully with intravenous thrombolytic therapy using 1.3 mg/kg of rt-PA with a 2-hour infusion time. In the absence of contraindications, most physicians consider using thrombolytic drugs in hemodynamically unstable patients who have a pulmonary embolism. A recent study described a subset of hemodynamically stable patients with right-ventricular dysfunction who also might benefit from thrombolytic therapy.
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D000293:Adolescent; D001249:Asthma; D015897:Comorbidity; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D018455:Protein S Deficiency / Q000150:complications* / Q000175:diagnosis; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
D010959:Tissue Plasminogen Activator