Regulation of protein tyrosine kinases in platelets.
Platelet activation is accompanied by a dramatic increase in tyrosine phosphorylation of many cellular proteins. Phosphorylation of these proteins occurs in successive waves during the activation process, suggesting that several distinct mechanisms, occurring in a temporal order, regulate protein tyrosine kinases and/or phosphatases in activated platelets. Several tyrosine kinases, including Src family kinases, Syk and FAK, have been implicated in these phosphorylation events. These kinases are regulated by distinct receptor-mediated events involving activation of their catalytic activity and alterations in their cellular localization.
ARIAD Pharmaceuticals Inc., Cambridge, MA 02139.
E A
EA
Clark
S J
SJ
Shattil
J S
JS
Brugge
D001792:Blood Platelets / Q000201:enzymology*; D006801:Humans; D015539:Platelet Activation / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000097:blood*
D011505:Protein-Tyrosine Kinases