[Functional capacity of fibrinogen and erythrocyte aggregation in the diabetic].
The aim of this work is to study the possible influence of a qualitative modification of fibrinogen on its capacity of erythrocyte aggregation. Fibrinogens were isolated and then purified from blood sample of 15 insulin-dependent diabetics and of 7 healthy subjects. The erythrocyte aggregative effect of the purified fibrinogens was measured for various concentrations (0 g/1-5 g/l). The erythrocyte aggregation was determined by the ECHO CELL whose functioning principle is based upon ultrasonic interferometry. Results allow one to distinguish three kinds of fibrinogen: the first kind inducing a similar erythrocyte aggregation as that obtained by the fibrinogens from healthy subjects, the second kind inducing an erythrocyte hyperaggregation, the third kind inducing an erythrocyte hypoaggregation. Thus the possibility of a qualitative abnormality of fibrinogen, affecting its erythrocyte aggregative capacity in diabetic patients, could be suggested. This qualitative abnormality of fibrinogen might be due to a modification of its molecular structure because of an abnormal elevated glycation during diabetes.
Unité de Recherches d'Hémorhéologie Clinique, Centre Hospitalier, Nevers.
T
T
Khodabandehlou
C
C
Le Devehat
M
M
Razavian
M
M
Boynard
M
M
Ba
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004903:Erythrocyte Aggregation / Q000502:physiology*; D005260:Female; D005340:Fibrinogen / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008297:Male; D013329:Structure-Activity Relationship
D005340:Fibrinogen
Capacité fonctionnelle du fibrinogène et agrégation érythrocytaire chez le diabétique.