[The role of segmental analgesic mechanisms in the development of silent myocardial ischemia in patients with initial coronary atherosclerosis].
In patients with ischemic heart disease (IHD) with early coronary atherosclerosis the ratio of the myocardial ischemia pain episodes (MIPE) to myocardial ischemia pain-free episodes (MIPFE) is 1:4. In IHD patients, an important role to play in the development of MIPFE has the first segmental link in the analgetic system leading to a segmental rise of the electropain sensitivity threshold. Blockade of alpha 1-adrenoreceptors with prazosinum decreases the activity of analgesic mechanisms and favours transition from MIPFE to MIPE. In patients with the initial stages of coronary atherosclerosis, prazosinum promotes a significant alleviation of both MIPFE and MIPE.
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D000787:Angina Pectoris / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004562:Electrocardiography / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D006334:Heart Function Tests / Q000187:drug effects; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D017288:Pain Threshold / Q000187:drug effects; D011224:Prazosin / Q000627:therapeutic use
D011224:Prazosin
Rol' segmentarnykh protivobolevykh mekhanizmov v razvitii bezbolevoĭ ishemii miokarda u bol'nykh s nachal'nym koronarnym aterosklerozom.