Karyotypic features of malignant tumors of the nasal cavity and paranasal sinuses.
Cytogenetic analysis of short-term cultures from 6 tumors of the nasal cavity and paranasal sinuses--one esthesioneuroblastoma, 2 adenocarcinomas and 3 squamous-cell carcinomas (SCC)--revealed clonal chromosome aberrations in all cases. The esthesioneuroblastoma had a complex hyperdiploid karyotype. None of the aberrations was similar to those previously described in short-term cultures or established cell lines from esthesioneuroblastomas. The 2 adenocarcinomas had complex karyotypic changes, which in both cases included rearrangements of bands 9p22 and 14q11. One SCC had 5 unrelated pseudodiploid clones, 1 displayed a highly complex karyotype, including rearrangement of band 11q13, and 1 had simple karyotypic changes with loss of 6q material and gain of 3q. These findings are similar to those described in head-and-neck SCC at other sites.
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Y
Y
Jin
F
F
Mertens
K
K
Arheden
N
N
Mandahl
J
J
Wennerberg
M
M
Dictor
S
S
Heim
F
F
Mitelman
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics; D018304:Esthesioneuroblastoma, Olfactory / Q000235:genetics* / Q000473:pathology; D005005:Ethmoid Sinus; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009296:Nasal Cavity; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm