Genomic cross-talk between the estrogen receptor and growth factor regulatory pathways in estrogen target tissues.
Cell proliferation and differentiation are modulated by both estrogens and growth factors. Even though these two kinds of effectors interact with receptors localized in different compartments of the cell, their nuclear end points are often on the same genes. We review here the first evidence for transcriptional interference between these two regulatory pathways which might be essential in understanding the control of cell proliferation and invasion in human estrogen-responsive cancers.
Institut National de la Santé et de la Recherche Médicale, Unité Hormones et Cancer (U 148), Montpellier, France.
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D
Chalbos
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Philips
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Rochefort
D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D004965:Estrogen Antagonists / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005786:Gene Expression Regulation; D016762:Genes, fos; D016758:Genes, jun; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology; D011960:Receptors, Estrogen / Q000187:drug effects*; D014158:Transcription, Genetic
D004965:Estrogen Antagonists; D004967:Estrogens; D006133:Growth Substances; D016755:Proto-Oncogene Proteins c-jun; D011960:Receptors, Estrogen; D000242:Cyclic AMP