[Comparison of sensitivity of six indices indicating genetic damage to human blood lymphocytes by benzo(a)pyrene].
Comparison of sensitivity of six indices, i.e., SCE, MN, CA, FADU, DRSI and UDS, in detection of genetic damage to human peripheral blood lymphocytes caused by benzo(a)pyrene were studied under the same condition for in vitro toxicant treatment and cell culture. Ratio of the slope of regression straight line of concentration-response to the standard deviation of regression staigy line from observed values was used as an indicator reflecting sensitivity of all the above indices. The results showed the order of sensitivities of all the above indices are as follows: SCE > MN > CA > FADU > DRSI > UDS. SCE and MN (cytokinesis block method) should be choice of indices to monitor genetic damage in human population exposed to benzo(a)pyrene. And, it is warranted to use FADU, as a simple, convenient and rapid method, in human population monitoring.
Yang
Y P
YP
Department of Toxicology, Beijing Medical University.
Xu
H E
HE
Lu
C L
CL
D001564:Benzo(a)pyrene / Q000633:toxicity*; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D012680:Sensitivity and Specificity; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001564:Benzo(a)pyrene