Protein and energy balance following femoral neck fracture in geriatric patients.
To elucidate the effect of total peripheral parenteral nutrition (TPPN) on protein kinetics following injury, we compared the whole-body leucine kinetic response using a primed-constant infusion of L-[1-14C]leucine in 33 elderly patients (aged 82 +/- 1.0 years) following hip fracture and 33 healthy elderly control subjects (aged 75 +/- 0.7 years). Following a 36-hour fast, leucine release from protein breakdown was 1.2 +/- 0.10 mumol.kg-1.min-1 and leucine incorporation into protein was 0.94 +/- 0.095 mumol.kg-1.min-1 in control subjects, and in injured subjects leucine release from protein breakdown was 1.3 +/- 0.14 mumol.kg-1.min-1 and leucine incorporation into protein was 0.97 +/- 0.092 mumol.kg-1.min-1. Control and injured subjects were then administered TPPN (protein, 1.5 g amino acids.kg-1; carbohydrate, 10.0 kcal.kg-1; lipid, 15.0 kcal.kg-1) for 24 hours, and leucine kinetics were redetermined. Compared with protein kinetics in the fasting state, leucine release from protein decreased to 1.0 +/- 0.14 mumol.kg-1.min-1 and leucine incorporation into protein increased to 1.16 +/- 0.097 mumol.kg-1.min-1 in control subjects. Injured patients also responded to TPPN with a decrease in leucine release from protein breakdown (1.12 +/- 0.156 mumol.kg-1.min-1) and an increase in leucine incorporation into protein (1.29 +/- 0.164 mumol.kg-1.min-1). These results indicate that in a geriatric population, whole-body leucine kinetics following hip fracture and the anabolic response to TPPN are not significantly altered from those of uninjured subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Research, Baptist Medical Centers, Birmingham, AL.
K M
KM
Nelson
E W
EW
Richards
C L
CL
Long
K R
KR
Martin
J W
JW
Geiger
S W
SW
Brooks
R E
RE
Gandy
W S
WS
Blakemore
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001769:Blood / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D005272:Femur Neck / Q000293:injuries*; D006620:Hip Fractures / Q000378:metabolism*; D006801:Humans; D007930:Leucine / Q000493:pharmacokinetics*; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D012016:Reference Values
D007930:Leucine; D009584:Nitrogen