Improved control over particle sizes and stability of concentrated fluorocarbon emulsions by using mixed fluorocarbon/hydrocarbon molecular dowels.
The use of a surfactant system consisting in equimolar amounts of egg yolk phospholipids and of a mixed fluorocarbon/hydrocarbon amphiphile (C8H17CH = CHC8F17) allows the preparation of concentrated (90% w/v, i.e. 47% v/v) emulsions of perfluorooctyl bromide (perflubron), with average particle sizes ranging from 0.12 to 16 microns post-sterilization, depending on the surfactant/fluorocarbon ratio. Emulsion droplet diameters varied linearly as a function of the emulsifier's concentration, thus allowing easy pre-determination of the emulsion's average particle size. Excellent stability was observed for the dowel-containing emulsions for at least 6 months at 40 degrees C over the whole domain of particle sizes investigated.
Cornélus
C
C
Unité de Chimie Moléculaire associée au CNRS, Faculté des Sciences, Université de Nice-Sophia Antipolis, France.
Krafft
M P
MP
Riess
J G
JG
D004355:Drug Stability; D004655:Emulsions; D005466:Fluorocarbons / Q000737:chemistry*; D006842:Hydrocarbons, Brominated; D006845:Hydrocarbons, Fluorinated; D016014:Linear Models; D008970:Molecular Weight; D010316:Particle Size; D013501:Surface-Active Agents
D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D006845:Hydrocarbons, Fluorinated; D013501:Surface-Active Agents; C091999:1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-9-octadecene; C003072:perflubron