Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4.
Through the use of somatic cell hybrids segregating either human or rat chromosomes, we determined the chromosome localizations of two genes encoding cAMP-specific phosphodiesterases (cAMP-PDEs). PDE4D, the gene encoding the cAMP-PDE isoform 3 (IVd), was assigned to human chromosome 5 and rat chromosome 2, and PDE4B, the gene encoding the cAMP-PDE isoform 4 (IVb), was assigned to human chromosome 1 and rat chromosome 5. These localizations extend the homology between rat chromosome 2 and human chromosome 5, on the one hand, and between rat chromosome 5 and human chromosome 1, on the other hand.
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode-St-Genèse, Belgium.
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Szpirer
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Szpirer
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Rivière
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Swinnen
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Vicini
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Conti
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002895:Chromosomes, Human, Pair 5; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D007527:Isoenzymes / Q000235:genetics*; D051379:Mice; D051381:Rats / Q000235:genetics*; D015183:Restriction Mapping
D007527:Isoenzymes; D015105:3',5'-Cyclic-AMP Phosphodiesterases