Prognostic values of preoperative and postoperative CEA and CA19.9 levels in pancreatic cancer.
Preoperative serum levels of carcinoembryonic antigen (CEA) and/or carbohydrate antigen 19.9 (CA19.9) were measured in 90 patients with advanced pancreatic cancer. CEA antigen was above the cutoff levels of 5.0 ng/ml in 51% of patients and CA19.9 was above the cutoff limit of 37 U/ml in 87% of patients. High preoperative CEA and CA19.9 levels were related to a poor prognosis of the patients. In multivariate analysis, the hazard rate was significantly higher in the high-CEA group (> 2.5 ng/ml) compared to the low-CEA group (< 2.4 ng/ml). An increase in CEA and/or CA19.9 within 1 month after the operation was also significantly related to the hazard rate. This study reconfirms the prognostic importance of preoperative and postoperative CEA and CA19.9.
Department of Surgery, Aichi Prefectural Hospital, Okazaki, Japan.
M
M
Yasue
J
J
Sakamoto
S
S
Teramukai
T
T
Morimoto
K
K
Yasui
N
N
Kuno
K
K
Kurimoto
Y
Y
Ohashi
D018395:CA-19-9 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D006801:Humans; D015592:Immunoradiometric Assay; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D011379:Prognosis; D011863:Radioimmunoassay; D012680:Sensitivity and Specificity
D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen