Modification of the responses of endothelin-1 to exhaustive physical exercise under simulated high-altitude conditions with acute hypoxia.
To assess whether acute alveolar hypoxia leads to the release of endothelin-1 (ET) in vivo, ET, cortisol (CORT), and lactate (LA) levels were determined in 15 healthy subjects at rest and during exhaustive incremental cycle ergometry on two separate test days. The subjects were to breathe a gas mixture with reduced O2 content ([H] fraction of inspired O2, 0.14) on one day and normal air on the other (N). Modified responses of LA and CORT to exhaustive incremental cycle ergometry on the H day indicated elevated anaerobic tissue metabolism and increased physical stress. With acute alveolar hypoxia, the response of ET to exhaustive physical labor was found to be augmented.
Kullmer
T
T
Department of Internal Medicine, University Hospital Frankfurt am Main, Germany.
Jungmann
E
E
Haak
T
T
Usadel
K H
KH
D000208:Acute Disease; D000328:Adult; D000531:Altitude; D016232:Endothelins / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D000860:Hypoxia / Q000097:blood*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D005082:Physical Exertion
D016232:Endothelins; D007773:Lactates; D019344:Lactic Acid; D006854:Hydrocortisone