[The efficacy of replacement therapy in hypothyroidism].
The use of L-thyroxin in the substitution therapy for hypothyrosis is, in our judgement, a most pathogenetically well-grounded option. In the early period of the treatment of hypothyrosis with L-thyroxin the total clearance of thyroxin is accelerated and is in inverse relationship to the initial blood hormone level. From the results of pharmacokinetic studies a specific individualized regimen is proposed of thyroxin administration in the early period of the treatment of hypothyrosis, which allows the thyroxin concentrations to be achieved within the range of 120-150 micrograms. The use of the above method results in clearing up pathognomonic symptomatology of hypothyrosis, normalization of the thyrotrophin and total cholesterin levels, improvement in central hemodynamics in 14-21 days, promotes complete rehabilitation of patients about 1 month after the initiation of treatment.
Beletskaia
O M
OM
Oleĭnikova
S P
SP
Natarov
V V
VV
Grincheko
T S
TS
Snopkov
Iu P
IuP
Vysotskaia
E V
EV
D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D005260:Female; D006207:Half-Life; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013974:Thyroxine / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013997:Time Factors
D013974:Thyroxine
Ob éffektivnosti zamestitel'noĭ terapii pri gipotireoze.