Hyperthermic reaction to haloperidol with rigidity, associated to central core disease.
A 21-year-old female patient with psychotic symptoms developed hyperthermia, muscular rigidity and hypertension after administration of haloperidol. A muscle biopsy showed some atrophic and necrotic fibers, and a great number of fibers with central cores in the oxidative enzyme preparations. A related syndrome, Malignant Hyperthermia (MH), is sometimes associated with central core disease. The present case shows an association of a hyperthermic syndrome related to haloperidol with central core disease.
Instituto Adolfo Lutz, Divisao De Patologia Da Universidade De Sao Paulo, Complexo Hospitalar Mandaqui.
E E
EE
Calore
M J
MJ
Cavaliere
N M
NM
Perez
D H
DH
Russo
A
A
Wakamatsu
D
D
Razzouk
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000209:etiology*; D009132:Muscles / Q000473:pathology; D017696:Myopathies, Nemaline / Q000150:complications* / Q000473:pathology; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis / Q000209:etiology*; D011618:Psychotic Disorders / Q000188:drug therapy
D006220:Haloperidol