A comparative trial between diclofenac-gentamicin and betamethasone-neomycin drops in patients undergoing cataract extraction.
Eighty patients were randomised in a single-masked parallel-group study to receive topically either the test drug, a diclofenac and gentamicin combination, or a betamethasone and neomycin combination after routine cataract extraction and intraocular lens implantation. Each group was assessed over a 6 week period for post-operative inflammation. The two drug combinations were equally effective in suppressing inflammation in the early post-operative stages and the diclofenac-gentamicin combination was slightly more effective in the later stages. The test drug was well tolerated and showed no adverse effects. We feel it is an effective and relatively safe drug which has a role as an anti-inflammatory agent after cataract extraction and has potential advantages in certain circumstances.
Suharwardy
J
J
Oxford Eye Hospital, UK.
Ling
C
C
Bell
J A
JA
Munton
C G
CG
D000368:Aged; D000369:Aged, 80 and over; D001623:Betamethasone / Q000627:therapeutic use; D002387:Cataract Extraction; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control*; D016037:Single-Blind Method
D005839:Gentamicins; D004008:Diclofenac; D001623:Betamethasone; D009355:Neomycin