Survival and transmitter expression of rat cholinergic medial septal neurons despite removal of hippocampus in the early postnatal period.
It has been shown that target-derived neurotrophins are not necessary for the survival of septohippocampal cholinergic neurons in adult rats. In this study, we have removed the hippocampus in early postnatal rats by unilateral excitotoxic N-methyl-D-aspartate lesions at postnatal days 5, 10 and 20. At postnatal day 70, numerous cholinergic neurons (60% of controls) were present in the medial septum on the lesioned side. This suggests that there is only a limited influence of target-derived neurotrophic factors to these cells also in development.
Institute of Anatomy, University of Freiburg, Germany.
M
M
Plaschke
E M
EM
Kasper
T
T
Naumann
M
M
Frotscher
D000818:Animals; D000831:Animals, Newborn; D002470:Cell Survival / Q000187:drug effects; D002795:Choline O-Acetyltransferase / Q000096:biosynthesis; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000096:biosynthesis*; D010275:Parasympathetic Nervous System / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018377:Neurotransmitter Agents; D016202:N-Methylaspartate; D002795:Choline O-Acetyltransferase