Necrotizing funisitis associated with Actinomyces meyeri infection: a case report.
Necrotizing funisitis is associated with an increased rate of stillbirth, perinatal infection, and preterm delivery. No one organism has been associated with necrotizing funisitis, although this condition has been linked with congenital syphilis in some studies. We report a case of necrotizing funisitis in a 24-year-old G2P0A2 woman who experienced preterm labor at 31 weeks of gestation. Examination of the placenta revealed severe chorioamnionitis and necrotizing funisitis; large numbers of gram-positive filamentous branching organisms could be seen on the surface of the cord and within Wharton jelly. Initial cultures of the placenta, which had not been maintained under anaerobic conditions after delivery, were negative. A fragment of the cord was then homogenized; anaerobic culture on brain-heart infusion agar yielded Actinomyces meyeri. This organism usually resides in the periodontal sulcus and has not been previously reported in the female genital tract. The mother gave a history of a dental abscess that flared up and drained with each of her three pregnancies; the pain was particularly severe during the last 2 months of this pregnancy, so she had the tooth removed after delivery. The infant was treated for prematurity and presumed sepsis and did well.
Wright
J R
JR
Department of Pathology and Surgery, Izaak Walton Killam Children's Hospital, Halifax, Nova Scotia, Canada.
Stinson
D
D
Wade
A
A
Haldane
D
D
Heifetz
S A
SA
D000190:Actinomyces / Q000302:isolation & purification*; D000196:Actinomycosis / Q000382:microbiology / Q000473:pathology*; D000328:Adult; D002821:Chorioamnionitis / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009336:Necrosis; D010920:Placenta / Q000382:microbiology / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000473:pathology*; D014470:Umbilical Cord / Q000382:microbiology / Q000473:pathology*