[Antigen-binding lymphocytes in pulmonary tuberculosis patients with the side effects of antitubercular preparations].
70 patients with pulmonary tuberculosis, experiencing side-effects associated with antibacterial preparations were examined as were 30 patients receiving similar therapy with no complications being developed, and 20 apparently healthy subjects. It was established that the level of antigen-binding lymphocytes depends on the extent of sensitization to the allergen in question and reaches the highest values in patients presenting with adverse reactions. Preliminary treatment of lymphocytes with a medicamentous preparation results in some reduction of the number of antigen-binding lymphocytes. Values for the index of restoration of stimulated expression of the receptors to the medicinal preparations by trypsinized lymphocytes are higher in patients experiencing adverse reactions than they are in patients with pulmonary tuberculosis, presenting with no ill-effects, and in donors.
N I
NI
Fedoruk
D000328:Adult; D000941:Antigens / Q000097:blood*; D000995:Antitubercular Agents / Q000009:adverse effects*; D001666:Binding Sites, Antibody; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
D000941:Antigens; D000995:Antitubercular Agents
Antigensviazuiushchie limfotsity u bol'nykh tuberkulezom legkikh s pobochnymi reaktsiiami na protivotuberkuleznye preparaty.