Increased expression of bcl-2 immunoreactivity in the developing cerebral cortex of the rat.
Bcl-2 proto-oncogene encodes a protein which may cancel the cell death programme in normal development and experimentally induced conditions. Strong bcl-2 immunoreactivity occurs in the neocortex and hippocampus of the developing rat during the 1st postnatal week. Bcl-2 immunoreactivity rapidly decreases from this age onwards to steady very low levels in adulthood. Since increased expression of bcl-2 immunoreactivity during cortical neurogenesis is coincidental in time with a special vulnerability of cortical neurons to naturally occurring cell death, it is suggested that bcl-2 may have a role in regulating cell death and survival during cortical morphogenesis.
Unidad Neuropatología, Hospital Príncipes de España, Universidad Barcelona, Spain.
I
I
Ferrer
A
A
Tortosa
E
E
Condom
R
R
Blanco
A
A
Macaya
A
A
Planas
D000818:Animals; D016923:Cell Death / Q000502:physiology; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism*; D005260:Female; D019204:GTP-Binding Proteins / Q000096:biosynthesis*; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D019204:GTP-Binding Proteins