Inhibitory activity of 3-methylenhydroxy-5-methoxy-2,4-dihydroxy tetrahydrofurane isolated from Selaginella lepidophyla on smooth muscle of Wistar rat.
A new compound, 3-methylenhydroxy-5-methoxy-2,4-dihydroxy tetrahydrofurane, has been isolated from a methanol extract of Selaginella lepidophyla. The structure is based on 1H-NMR, 13C-NMR and MS analysis. The compound was tested on uterus (oestrus), ileum and duodenum of Wistar rats. It proved to have a slight inhibitory effect on the contraction response of the uterus, but it did not have any effect on the two other muscles.
Pérez
S
S
Universidad Autónoma Metropolitana, Xochimilco, Mexico, Mexico.
Pérez
R M
RM
Pérez
C
C
Zavala
M A
MA
Vargas
R
R
D000818:Animals; D005260:Female; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D008800:Mexico; D009130:Muscle, Smooth / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D015206:Southwestern United States; D014590:Uterine Contraction / Q000187:drug effects
C091905:3-methylenehydroxy-5-methoxy-2,4-dihydroxytetrahydrofuran; D005663:Furans