Stereoselective disposition of ibuprofen enantiomers in infants.
The pharmacokinetics of the enantiomers of ibuprofen were investigated after oral administration of a single 7.6 +/- 0.3 mg kg-1 dose of the racemate in 11 infants. Mean (+/- s.d.) half-lives were 1.6 +/- 0.5 h for S(+) and 1.5 +/- 0.5 h for R(-) and mean (+/- s.d.) AUC values were 31.5 +/- 14.3 mg l-1 h for S(+) and 36.6 +/- 13.8 mg l-1 h for R(-). Since plasma concentrations of the active S(+)-isomer were lower than those reported in adults, a higher dosage might be required in infants.
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
E
E
Rey
A
A
Pariente-Khayat
L
L
Gouyet
F
F
Vauzelle-Kervroëdan
G
G
Pons
P
P
D'Athis
M C
MC
Dubois
I
I
Murat
C
C
Lassale
M
M
Goehrs
D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid; D003198:Computer Simulation; D005260:Female; D006207:Half-Life; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D007223:Infant; D008297:Male; D013237:Stereoisomerism
D007052:Ibuprofen