A novel cytotoxic macrolide, superstolide B, related to superstolide A, from the New Caledonian marine sponge Neosiphonia superstes.
The structure of a new cytotoxic macrolide, superstolide B [1], isolated from the deep water sponge Neosiphonia superstes, collected off New Caledonia, was elucidated mainly on the basis of nmr data. Compound 1 is closely related to superstolide A [2], a major cytotoxic component isolated from that organism, but lacks the 25-hydroxyl group found in 2 and has a C-24 (C-25)-double bond.
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
M V
MV
D'Auria
L
L
Gomez Paloma
L
L
Minale
A
A
Zampella
C
C
Debitus
D000818:Animals; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D009510:New Caledonia; D011161:Porifera; D013329:Structure-Activity Relationship; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000302:isolation & purification
D003603:Cytotoxins; D018942:Macrolides; D013764:Tetrahydronaphthalenes; C091984:superstolide A; C091985:superstolide B