Effect of perfluorochemical emulsion on lipoproteins of plasma blood.
The effect of perfluorocarbons (PFC, Perfluorodecalin/Fogalin) on the lipoprotein level in plasma was studied. The PFC emulsion (FCE) was injected i.v. at a dose of 6 g PFC per kg of body weight into male Wistar rats weighing 250-280 g. The lipoproteins were separated by preparative centrifugation. It was found that PFCs influence the metabolism of lipoproteins. The greatest depletion of cholesterol level occurs in the HDL fraction of lipoproteins 3 and 24 hrs after injection. There is no relationship between the level of cholesterol in plasma and cholesterol lipoproteins. The content in lipoproteins, however, amounts to half the level of the cholesterol of plasma 72 hrs after injection. Based on these facts it is possible to conclude that when PFCs leave the cells of organs, they are carmed in the blood stream as a complex which contains at least PFCs, cholesterol and triglycerides.
Department of Medical Biotechnology, Research Institute of Experimental and Clinical Immunology, Moscow, Russia.
N N
NN
Doronina
O A
OA
Kurmacheva
N I
NI
Afonin
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004655:Emulsions; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D014461:Ultracentrifugation
D004655:Emulsions; D005466:Fluorocarbons; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol