[Experimental myocardial infarct in rats induced by ligation of the coronary vessels. Electrophysiologic and ultrastructural study].
Ischemic damage of rat myocardium was produced by ligature of coronary arteries. Animals were studied in three groups: those dying of dysrhythmia, animals after ischemia lasting 10 minutes and 20 minutes. All of them were investigated by ECG and extrasystoles, bigeminia, trigeminia, salvos, ventricular tachycardia and fibrillation were found. Groups with ECG finding were sampled for electron microscopy. Ultrastructural findings documented ischemic damage of cardiomyocytes-clearing of basal sarcoplasm, clearing of perinuclear zones, occurring of cytolytic regions and even necrotic disintegration of cardiocytes.
Oddelenie biológie a farmakologickej propedeutiky katedry farmakológie FaF UK, Bratislava.
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Bózner
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Kuzelová
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Z
Matĕjková
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A
Kulcsár
D000818:Animals; D004562:Electrocardiography; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
Experimentálny infarkt myokardu u potkanov vyvolaný ligatúrami koronárnych ciev. Elektrofyziologická a ultrastrukturálna stúdia.