Effect of aging on autoimmune response to rat male accessory glands: young, but not aged, antigen-presenting cells efficiently induce suppression in aged rats.
The present report analyzes the suppressor cell system of aged rats in an experimental model of autoimmunity to rat male accessory glands (RAG). A state of specific suppression to RAG was induced when young rats are pretreated with peritoneal cells (PC) obtained from syngeneic young rats i.p. injected 2 h previously with chromatographic fraction I (Sephadex G-100) (FI) of RAG (yFI-PC). Although the yFI-PC injection diminished the DTH in aged rats the autoimmune response remained positive. Peritoneal cells obtained from aged rats injected with FI of RAG (oFI-PC) did not suppress the DTH response in either aged or young rats. In both young and aged, pretreatment with yFI-PC stimulates spleen cells capable of inducing suppression (inductor-phase suppressor cells) when they are transferred to young recipients. However, the spleen inductor-phase suppressor cells of 12-month-old rats are unable to suppress the autoimmune response in their own aged environment. To obtain effective suppression in 12-month-old rats, the injection of yFI-PC was necessary prior to and subsequent to immunization. In this work we observe that 12-month-old rats could efficiently induce inducer phase and effector-phase suppressor cells when the adequate young antigen-presenting cells were present to stimulate them.
Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacio Nacional de Córdoba, Cuidad Universitaria, Argentina.
M C
MC
Pistoresi-Palencia
M
M
Romero-Piffiguer
G
G
Morón
M E
ME
Ferro
D000375:Aging / Q000502:physiology*; D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000502:physiology*; D015551:Autoimmunity / Q000502:physiology*; D017690:Cell Transplantation; D005837:Genitalia, Male / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis; D008297:Male; D010537:Peritoneum / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar
D008263:Macrophage Migration-Inhibitory Factors