[Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries].
Thirty mitral valvular surgical patients were randomly divided into three groups for study of protective effects of Ginsenoside on myocardiac ischemic and reperfusion injuries. In GI, 11 patients (controls), no Ginsenoside was used, in GII, 11, Ginsenoside in total was added into the cardioplegic solusion made in our hospital, and in GIII, 8, instead of Ginsenoside in total Ginsenoside Rb was added. During operation comparative studies were made of pre- and postoperative cardiac functions with intraoperative transesophageal echocardiography and ultrastructures of myocardiac cells with electromicroscopy. We conclude that both Ginsenoside in total and Ginsenoside Rb have protective effects on myocardiac ischemic and reperfusion injuries in open heart surgery, and the effect of Ginsenoside in total is even better than that of Ginsenoside Rb.
Department of Cardiothoracic Surgery, Second Affiliated Hospital, Hunan Medical University, Changsha.
Y
Y
Zhan
X H
XH
Xu
Y P
YP
Jiang
D002314:Cardioplegic Solutions; D002315:Cardiopulmonary Bypass; D005260:Female; D036145:Ginsenosides; D006349:Heart Valve Diseases / Q000601:surgery; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008943:Mitral Valve / Q000601:surgery*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000648:ultrastructure; D005894:Panax; D010946:Plants, Medicinal; D012503:Saponins / Q000008:administration & dosage*
D002314:Cardioplegic Solutions; D036145:Ginsenosides; D012503:Saponins; C048026:ginsenoside Rb2