Microbial adhesins recognizing extracellular matrix macromolecules.
Microorganisms express a family of cell-surface adhesins that specifically recognize and bind components of the extracellular matrix. Adhesion of microorganisms to host tissues represents a critical phase in the development of many types of infections. Recent studies have focused on the mechanisms of microbial attachment at a molecular level, including the identification of ligand-binding domains in several cell-surface adhesins from Gram-positive bacteria and the construction of adhesin-deficient isogenic mutants.
Institute of Biosciences and Technology, Texas A & M University, Houston 77030.
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Patti
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Höök
D018829:Adhesins, Bacterial / Q000235:genetics / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D002448:Cell Adhesion / Q000502:physiology*; D003094:Collagen / Q000378:metabolism; D015195:Drug Design; D005109:Extracellular Matrix / Q000502:physiology*; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding; D014774:Virulence / Q000502:physiology
D018829:Adhesins, Bacterial; D000900:Anti-Bacterial Agents; D005353:Fibronectins; D003094:Collagen