4H-pyrrolo[1,2-a]thieno[3,2-f] and 4H-pyrrolo[1,2-a]thieno-[2,3-f][1,4]diazepines: synthesis and pharmacological evaluation.
As an extension of a previous work, in which a number of 4H-pyrrolo-[1,2-a]thieno[2,3-f][1,4]diazepines were described, a new series of derivatives of the isomeric pyrrolo[1,2-a]thieno[3,2-f]diazepines ring system has been synthesized. The products obtained, together with those reported in the previous paper, were tested for acute toxicity and CNS activity in mice.
Instituto de Química Médica, CSIC, Madrid, Spain.
S
S
Vega
M S
MS
Gil
V
V
Darias
C C
CC
Sánchez Mateo
M A
MA
Expósito
M L
ML
Tello
L M
LM
Albertos
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D014151:Anti-Anxiety Agents; D001381:Azepines; D011758:Pyrroles