[Insulin receptors and mechanism of action of insulin and of insulin-like growth factors].
A novel mechanism of activation of the insulin and IGF-I receptors by their respective ligands is proposed, whereby the bivalent ligand bridges the two receptor alpha subunits at opposite sites in a symmetrical receptor structure. The proposed mechanism accounts for the binding stoichiometry and the phenomenon of negative cooperativity. It may play an important role in the regulation of mitogenesis.
Unité de Biochimie, département de Chimie de l'Université catholique de Louvain.
P
P
De Meyts
D006801:Humans; D007328:Insulin / Q000493:pharmacokinetics / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000493:pharmacokinetics / Q000494:pharmacology*; D008024:Ligands; D011485:Protein Binding; D011972:Receptor, Insulin / Q000187:drug effects* / Q000378:metabolism
D007328:Insulin; D008024:Ligands; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin
Récepteurs et mécanismes d'action de l'insuline et des facteurs de croissance insulino-semblables.