Aspiration cytopathology of malignant melanoma in children. A morphologic spectrum.
Malignant melanoma (MM) is an uncommon neoplasm in the practice of pediatric cytopathology. The clinical and morphologic features of three white children with this neoplasm diagnosed by fine needle aspiration biopsy are described. All cytologic diagnoses were subsequently confirmed histologically. Two children were 16 years old and one was 9 years old. Two patients had metastatic MM to head and neck lymph nodes. In one of these children, a prior diagnosis of MM was known, whereas in the other it was unsuspected. A primary melanoma of the iris developed in the third child. The cytopathology of these children are similar to that described in adults. With the cytologic similarities, some striking differences were seen. Principal among these was the abundance of melanin in one case, its uneveness in another, and its absence in a third. The variation in individual cell morphology among the three cases is also described. Malignant melanoma is a rare neoplasm of children that can be recognized by fine-needle aspiration cytopathology.
Department of Pathology, Virginia Commonwealth University/Medical College of Virginia, Richmond 23298.
P E
PE
Wakely
W J
WJ
Frable
K R
KR
Geisinger
D000293:Adolescent; D001707:Biopsy, Needle; D002648:Child; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D006651:Histocytochemistry; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D015811:Iris Neoplasms / Q000378:metabolism / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D009382:Neoplasms, Unknown Primary