Reaction of lysine with estrone 3,4-o-quinone.
Reaction of lysine with estrone 3,4-o-quinone gave a complex mixture of products. Six compounds were isolated and identified using spectroscopic techniques. Among the reaction products isolated were 4-hydroxyestrone (2), 3-aminoisoestrone (3), 3-(N-pentyl-5-amino)-isoestrone (4), 1-lysylestrone 3,4-o-iminoquinone (5), and two dimeric products of 3,4-catechol estrone (6 and 7).
Tabakovic
K
K
Department of Medicinal Chemistry, University of Minnesota, Minneapolis 55455.
Abul-Hajj
Y J
YJ
D004963:Estrenes / Q000737:chemistry*; D002393:Estrogens, Catechol / Q000737:chemistry*; D006894:Hydroxyestrones / Q000737:chemistry; D008239:Lysine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010777:Photochemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D004963:Estrenes; D002393:Estrogens, Catechol; D006894:Hydroxyestrones; C026418:4-hydroxyestrone; C044208:1,5(10)-estradiene-3,4,17-trione; D008239:Lysine