Extracellular matrix gene expression in experimental glomerulonephritis.
Recent studies using animal models of glomerulonephritis indicate that steady-state levels of mRNAs encoding basement membrane proteins are frequently, but not universally, increased in parallel and that mRNAs encoding interstitial matrix proteins represent a separate set of genes that may also display coordinate regulation. A variety of maneuvers that ameliorate progressive glomerulosclerosis may act, at least in part, by suppressing glomerular cell matrix protein gene expression. The observed coordinate regulation of matrix genes may be a consequence of shared genetic regulatory sequences. Future therapies designed to retard glomerulosclerosis may take advantage of similarities among the extracellular mediators and regulatory sequences that influence matrix gene expression.
Kopp
J B
JB
National Institutes of Dental Research, National Institutes of Health, Bethesda, Maryland.
Bruggeman
L A
LA
Klotman
P E
PE
D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D015870:Gene Expression / Q000502:physiology*; D005921:Glomerulonephritis / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis
D012333:RNA, Messenger