Vitamin nutrition status and homocysteine: an atherogenic risk factor.
In an epidemiologic survey, a marginal status of folic acid, vitamin B12, and vitamin B6 was shown to be associated with hyperhomocysteinemia. In a case-control study, a low plasma folate concentration was associated with increased coronary heart disease risk. This phenomenon appears to be mediated by folate's effect on homocysteine metabolism. Both studies offer further perspectives on homocysteine as an atherogenic risk factor.
Department of Chemical Pathology, University of Pretoria, South Africa.
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D001161:Arteriosclerosis / Q000209:etiology*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000209:etiology; D005492:Folic Acid / Q000097:blood / Q000502:physiology*; D006710:Homocysteine / Q000097:blood / Q000502:physiology*; D006801:Humans; D009752:Nutritional Status; D011736:Pyridoxine / Q000097:blood / Q000502:physiology*; D012307:Risk Factors; D014805:Vitamin B 12 / Q000097:blood / Q000502:physiology*
D006710:Homocysteine; D005492:Folic Acid; D011736:Pyridoxine; D014805:Vitamin B 12