Organelle transport and sorting in axons.
Recent advances of the past year in the field of organelle transport have documented the existence of numerous kinesin-related proteins and the presence of multiple conventional kinesins within neurons. Biochemical and genetic mutant analyses indicate that different kinesin superfamily members transport different organelles. In addition to microtubule-based systems, actin filaments and myosin motors are associated with organelle transport in axons. The great diversity of motor proteins suggests that they may play a role in sorting, in addition to transport.
Coy
D L
DL
Department of Physiology and Biophysics, University of Washington, Seattle 98195.
Howard
J
J
D000199:Actins / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000378:metabolism*; D001692:Biological Transport; D003593:Cytoplasm / Q000378:metabolism; D004398:Dyneins / Q000378:metabolism; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D015388:Organelles / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
D000199:Actins; D012333:RNA, Messenger; D004398:Dyneins; D016547:Kinesins