[The protection of gut mucosa with early enteral feeding in burned rabbits].
The mechanisms of the protection of gut mucosa with early enteral feeding in burns were investigated. A 25% TBSA burn rabbit model, in which a gastrostomy, and a blind segment of the jejunum were formed before the thermal injury. 39 rabbits were randomly divided into three groups: A. burn and feeding with the nutritional fluid within 30 minutes postburn through gastrostomy. B. same as A except feeding with cold water instead of nutritional fluid; and C. no burn and fed freely. The results showed that burn injury caused an increase in mucosal oxygen consumption, intestinal uric acid formation and MDA (malondialdehyde) production, and decrease in submucosal blood flow. However, these were significantly improved by early enteral feeding after burn injury. The changes in the mucosa of the jejunal blind segment were similar to that of the rest of jejunum. It indicated that the effect of enteral feeding might be a systemic as well as a local one. It is concluded that the early enteral feeding can maintain the mucosal function and structure of the gut, as evidenced by a decrease in the mucosal hypermetabolism, improvement in submucosal blood flow and reduction in gut injuries as a result of reperfusion.
Burn Institute, South-western Hospital, Third Military University, Chongqing.
J
J
Yu
S
S
Wang
A
A
Li
D000818:Animals; D002056:Burns / Q000503:physiopathology* / Q000628:therapy; D004750:Enteral Nutrition; D005260:Female; D005774:Gastrostomy; D007413:Intestinal Mucosa / Q000098:blood supply / Q000378:metabolism*; D007583:Jejunum / Q000601:surgery; D008297:Male; D010101:Oxygen Consumption; D011817:Rabbits; D011897:Random Allocation; D012039:Regional Blood Flow; D013997:Time Factors