Microbial multidrug-resistance ABC transporters.
Multidrug resistance in tumor cells is often caused by the increased efflux of a wide variety of drugs, mediated by P glycoprotein, a member of the superfamily of ATP-binding cassette (ABC) transporters. The genes encoding members of this superfamily have also been isolated from drug-resistant microorganisms, and the role of microbial ABC transporters in drug resistance is being investigated.
Ouellette
M
M
Service d'Infectiologie du CHUL, Université Laval, Québec, Canada.
Légaré
D
D
Papadopoulou
B
B
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000502:physiology; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001419:Bacteria / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007891:Leishmania / Q000235:genetics; D051379:Mice; D009369:Neoplasms / Q000503:physiopathology; D010961:Plasmodium / Q000235:genetics; D015003:Yeasts / Q000235:genetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters