Different roles for KinA, KinB, and KinC in the initiation of sporulation in Bacillus subtilis.
Activation (phosphorylation) of the transcription factor encoded by spo0A is essential for the initiation of sporulation in Bacillus subtilis. At least three histidine protein kinases are involved in the phosphorylation of Spo0A. Under some growth conditions, KinA was the primary kinase, but under other conditions, KinB had the more critical role. KinC was required for the initial activation of Spo0A, even in the presence of KinA and KinB.
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
J R
JR
LeDeaux
N
N
Yu
A D
AD
Grossman
D001412:Bacillus subtilis / Q000502:physiology*; D001426:Bacterial Proteins / Q000502:physiology*; D003470:Culture Media; D004268:DNA-Binding Proteins / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D000071677:Histidine Kinase; D010641:Phenotype; D010770:Phosphotransferases; D011494:Protein Kinases / Q000502:physiology*; D013171:Spores, Bacterial / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics
C060762:AbrB protein, Bacillus subtilis; D001426:Bacterial Proteins; D003470:Culture Media; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C075521:kinA protein, Bacillus subtilis; D010770:Phosphotransferases; D011494:Protein Kinases; D000071677:Histidine Kinase; C081245:kinB protein, Bacillus subtilis