Alteration of plasma endothelin-1 by exercise at intensities lower and higher than ventilatory threshold.
The purpose of this study was to investigate whether the release of endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, is induced by exercise. Venous plasma concentrations of ET-1 were measured by sandwich-enzyme immunoassay before and after endurance exercise with a cycle ergometer at different intensities. Male intercollegiate athletes participated in the study and performed cycle ergometer exercise of 30 min duration at intensities of 90 or 130% of their individual ventilatory threshold (VT). The plasma concentration of ET-1 was slightly but significantly increased after exercise at 90% and markedly increased after exercise at 130% of individual VT. The increase in ET-1 was greatest 30 min after exercise at both intensities. It was first demonstrated that the plasma concentration of ET-1 was significantly increased after exercise: the greater the intensity, the greater the extent of the increase in plasma ET-1 concentration. However, the precise physiological roles of ET-1 during exercise remain to be elucidated.
Institute of Health and Sport Sciences, University of Tsukuba, Japan.
S
S
Maeda
T
T
Miyauchi
K
K
Goto
M
M
Matsuda
D000293:Adolescent; D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology*; D001127:Arginine Vasopressin / Q000097:blood; D001835:Body Weight / Q000502:physiology; D016232:Endothelins / Q000097:blood*; D005080:Exercise Test; D006339:Heart Rate / Q000502:physiology; D006400:Hematocrit; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010807:Physical Endurance / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*
D016232:Endothelins; D001127:Arginine Vasopressin; D009638:Norepinephrine