The usefulness of severe combined immunodeficiency (SCID) mice to study human carcinogenesis.
In the present study, we engrafted normal colonic epithelial and histologically diagnosed colonic adenomas from a familial adenomatous polyposis (FAP) patient into severe combined immunodeficient (SCID) mice and subsequently examined them histologically and molecular biologically. Successful engraftment and metastasis was observed. The facts that human normal colonic epithelium and adenomatous polyps can take in SCID mice indicates the possibility that this human SCID mouse system will be useful for investigating the dynamics of human carcinogenesis in various tissues.
Ito
T
T
Department of Radiobiology, Radiation Effects Research Foundation, Hiroshima, Japan.
Seyama
T
T
Kyoizumi
S
S
Teraoka
S
S
Iwamoto
K S
KS
Mizuno
T
T
Tsuyama
N
N
Asahara
T
T
Dohi
K
K
Akiyama
M
M
D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000818:Animals; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics; D017491:Genes, APC; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology; D008297:Male; D051379:Mice; D016513:Mice, SCID / Q000502:physiology*; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
D004273:DNA, Neoplasm