Phenotypic analysis of cerebrospinal fluid cells over the course of Lyme meningoradiculitis.
Cytologic cerebrospinal fluid abnormalities that most distinctly point to the diagnosis of Lyme meningoradiculitis are pronounced mononuclear pleocytosis composed mainly of T lymphocytes, large amounts of plasma cells and IgM-positive B cells. In this study, repeat examinations revealed decreasing cell numbers and almost normal cell counts 100-130 days after the onset. B cells persisted over the whole observation period in five of six patients and were not related to any clinical symptoms or signs indicative of persistent meningitis or central nervous system involvement. The CD4/CD8 ratio of the helper/inducer and suppressor/cytotoxic lymphocyte subsets declined in all the patients after antibiotic treatment. It might be useful as a marker of the disease activity.
Sindern
E
E
Department of Neurology, Ruhr University, Kliniken Bergmannsheil, Bochum, Germany.
Malin
J P
JP
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D015748:Borrelia burgdorferi Group / Q000276:immunology; D016516:CD4-CD8 Ratio; D002452:Cell Count; D002490:Central Nervous System / Q000737:chemistry / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000166:cytology* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid; D008193:Lyme Disease / Q000276:immunology / Q000473:pathology*; D008297:Male; D016920:Meningitis, Bacterial / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D010641:Phenotype; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D007136:Immunoglobulins