DNA content and the proliferation marker Ki-67 as prognostic indicators in renal cell carcinoma.
Patients suffering from renal cell carcinoma have a generally poor prognosis. Even cases that are clinically in comparable stages can, however, take quite different courses. The basic prognostic factors, histological grade and TNM stage do not do justice to the heterogeneous biological behavior of this tumor entity. In this study, the possible prognostic indicators, DNA content and proliferation rate, assessed with Ki-67, were compared with the histological grade and the TNM stage. Though there was no correlation between the proliferation rate (Ki-67) and the two, there was a significant correlation between DNA content and both histological grade and TNM stage.
Department of Urology, University of Kiel, Germany.
I
I
Papadopoulos
K
K
Weichert-Jacobsen
E
E
Sprenger
H H
HH
Wacker
D000782:Aneuploidy; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D019394:Ki-67 Antigen; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D011003:Ploidies; D011379:Prognosis; D011446:Prospective Studies
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins