Intake and fecal excretion of PCDDs, PCDFs, HCB and PCBs (138, 153, 180) in a breast-fed and a formula-fed infant.
Intake and fecal excretion of PCDDs, PCDFs, HCB and PCBs (IUPAC Nos. 138, 153, 180) were measured in a breast-fed and a formula-fed infant at the age of 1 and 5 months. As expected, the intake of these compounds was clearly higher in the breast-fed infant. In this baby an almost complete absorption was observed for lower chlorinated PCDDs and PCDFs and also for HCB and PCBs, whereas for hepta- and octachlorinated PCDDs and PCDFs fecal excretion was considerably higher (from 20% up to nearly 100% of the intake). Due to low concentrations in diet and feces of the formula-fed infant an evaluation was possible only for a few compounds at the age of 5 months. These values were in the same range when compared with those of the breast-fed infant. For collection of feces new cotton diapers were used which were pre-extracted in order to reduce the levels of polychlorinated compounds. Unexpectedly, after washing the tissue a much higher contamination was observed which made a calculation of fecal excretion rates in the formula-fed infant at the age of 1 month impossible.
Kinderklinik der FU Berlin (Kaiserin Auguste Victoria Haus), Germany.
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Abraham
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Hille
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Ende
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Helge
D001942:Breast Feeding; D004147:Dioxins / Q000008:administration & dosage / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005260:Female; D006581:Hexachlorobenzene / Q000032:analysis / Q000378:metabolism; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000008:administration & dosage / Q000378:metabolism*; D007223:Infant; D007225:Infant Food; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000378:metabolism*; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism
D004147:Dioxins; D006843:Hydrocarbons, Chlorinated; D000072317:Polychlorinated Dibenzodioxins; D006581:Hexachlorobenzene; D011078:Polychlorinated Biphenyls