[Takayasu's arteritis. A seroimmunological test of its relationship to mycobacterial infection].
Takayasu's arteritis is an inflammatory arteritis of unknown origin. It affects the aorta, its main branches and at times the pulmonary artery. Takayasu's arteritis is a worldwide disease, however, there is predilection to affect young women of mongoloid ancestry, therefore most cases do occur in the Far East and Latin America. For more than 50 years a relationship with mycobacterial infection has been sought without definite proof. In this investigation we found a circulating IgG antibody in the sera of Takayasu's arteritis patients, which recognizes a 38 kD glycoprotein of M. tuberculosis. This glycoprotein is an specific antigen in the human immune response against mycobacterial infection.
Hernández Pando
R
R
Instituto de Investigaciones Biomédicas UNAM, México, D.F.
Espitia
C
C
Mancilla
R
R
Reyes
P A
PA
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000918:Antibody Specificity; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology; D012698:Serologic Tests; D013625:Takayasu Arteritis / Q000175:diagnosis* / Q000209:etiology; D014376:Tuberculosis / Q000150:complications / Q000175:diagnosis*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
Arteritis de Takayasu. Prueba seroinmunológica de su relación con infección por micobacterias.