DNA marker D11S384 shows zero recombination with the ataxia-telangiectasia locus in North American families.
At the genetic locus D11S384, one probe detects a Taql RFLP and another detects a RFMP. In 52 pedigrees of North American A-T patients, parental haplotypes based on these two bi-allelic systems have a heterozygosity of 0.69 and a PIC of 0.64. No recombinant events between D11S384 and the A-T locus were detected in the 43 pedigrees in which this marker locus was informative.
Division of Human Molecular Genetics, New York Medical College, Valhalla.
N J
NJ
Lench
P
P
Athma
A
A
Ottaiano
W M
WM
Sribney
E
E
Highsmith
M
M
Swift
D000483:Alleles; D001260:Ataxia Telangiectasia / Q000235:genetics*; D001483:Base Sequence; D003241:Consanguinity; D004247:DNA / Q000235:genetics*; D004259:DNA-Directed DNA Polymerase; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D008969:Molecular Sequence Data; D009656:North America; D010375:Pedigree; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D019914:Taq Polymerase
D005819:Genetic Markers; D004247:DNA; D019914:Taq Polymerase; D004259:DNA-Directed DNA Polymerase