[Major hypercalcemia revealing sarcoidosis].
We reported a new case of sarcoidosis disclosed by a symptomatic severe hypercalcemia. Increase of 1,25-dihydroxyvitamin D is secondary to an extrarenal production by alveolar macrophages and sarcoid granuloma. Glucocorticoid administration produces a prompt and persistent decrease in serum and urinary levels of calcium.
Cailleux
N
N
Service de Médecine Interne-Angéiologie, Hôpital de Bois-Guillaume, Centre Hospitalier Universitaire, Rouen.
Raspaud
C
C
Levesque
H
H
Benhamou
D
D
Vuillermet
P
P
Muir
J F
JF
Courtois
H
H
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D002117:Calcitriol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008171:Lung Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016676:Macrophages, Alveolar / Q000378:metabolism; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
D000305:Adrenal Cortex Hormones; D002117:Calcitriol
Hypercalcémie majeure révélatrice d'une sarcoïdose.