Nephrotic syndrome and adjuvant treatment with tamoxifen for early breast cancer. Case report and review of the literature.
A 56 year old postmenopausal patient underwent a right radical mastectomy for a stage I breast cancer. An adjuvant treatment with tamoxifen was planned, but, because of patient's choice, a regular administration of the endocrine treatment started only one year after the operation. After a very short period of drug administration, she developed a steroid responsive nephrotic syndrome. We have reviewed the international literature concerning drug-induced renal disease; this is the first case of a tamoxifen-induced nephrotic syndrome.
Lauro
S
S
Dipartimento di Medicina Sperimentale, Policlinico Umberto I, Universita, La Sapienza, Roma, Italy.
Lalle
M
M
D'Andrea
M R
MR
Vecchione
A
A
Frati
L
L
D001943:Breast Neoplasms / Q000188:drug therapy*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000139:chemically induced*; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
D013629:Tamoxifen