Endothelin and myocardial ischemia.
Endothelin is a potent vasoconstrictor with a wide range of effects on the heart. Changes in myocardial and circulating levels of endothelin have been described in various experimental models of myocardial ischemia, and in humans with acute myocardial infarction and different forms of angina pectoris. The role played by endothelin in the different states of myocardial ischemia is unclear. However, myocardial damage has been shown to be reduced in several experimental models of myocardial infarction by administering agents that block the action of endothelin. The aim of this review article is to present the current literature concerning the interaction between endothelin and the various forms of myocardial ischemia, and to explore the significance of such interactions.
Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Sheba Medical Center, Tel Hashomer, Israel.
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D
Hasdai
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R
Kornowski
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A
Battler
D000787:Angina Pectoris / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D004594:Electrophysiology; D016232:Endothelins / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism* / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000503:physiopathology; D015427:Reperfusion Injury / Q000503:physiopathology; D014661:Vasoconstriction / Q000187:drug effects
D016232:Endothelins