The human OTF1 locus which overlaps the CD3Z gene is located at 1q22-->q23.
The human OTF1 locus encoding the Oct-1 protein has previously been mapped to chromosome 1 cen-->q32 by analysis of somatic cell hybrids. We report here the regional localization of OTF1 to 1q22-->q23 by fluorescence in situ hybridization. The physical linkage of the CD3Z gene to the OTF1 transcription unit also refines the location of the CD3Z locus to 1q22-->q23.
Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia.
R A
RA
Sturm
H J
HJ
Eyre
E
E
Baker
G R
GR
Sutherland
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000235:genetics*; D008040:Genetic Linkage; D051863:Host Cell Factor C1; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D050811:Octamer Transcription Factor-1; D014157:Transcription Factors / Q000235:genetics*
D015342:DNA Probes; D004268:DNA-Binding Proteins; C497692:HCFC1 protein, human; D051863:Host Cell Factor C1; D050811:Octamer Transcription Factor-1; C494165:POU2F1 protein, human; D014157:Transcription Factors