Hypericum treatment of mild depressions with somatic symptoms.
In a randomized, placebo-controlled, double-blind study, 39 patients with depression with somatic symptoms were treated with hypericum extract LI 160. The therapy lasted for 4 weeks; the dosage was 300 mg three times daily. At the onset of the study as well as after 2 and 4 weeks, the following criteria were analyzed: HAMD, B-L, CGI, and vegetative symptoms. The results show a significant improvement in the active treatment group at the 5% level as compared to placebo. Seventy percent of the patients treated with LI 160 were free of symptoms after 4 weeks. Typical symptoms of the depression such as lack of activity, tiredness, fatigue, and disturbed sleep, were especially responsive. In no case were any undesirable side effects observed.
Hübner
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Lichtwer Pharma GmbH, Berlin, Germany.
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D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D020902:Hypericum; D008297:Male; D008875:Middle Aged; D010569:Perylene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011594:Psychometrics; D011794:Quercetin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014966:Xanthenes / Q000627:therapeutic use*
D000928:Antidepressive Agents; D010936:Plant Extracts; D014966:Xanthenes; D010569:Perylene; D011794:Quercetin