Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas.
Inactivation of the retinoblastoma (Rb) gene has been implicated in the genesis and progression of a number of tumor types, including prostatic adenocarcinomas. We have analyzed a series of 46 surgically-resected human prostatic adenocarcinomas for allelic loss of the Rb gene with PCR amplification of a highly polymorphic region of the gene. 41 of 46 tumors (89%) were informative and 11 of these (27%) had lost one Rb allele. The relative frequency of this occurrence suggests that inactivation of the retinoblastoma gene may be an important event in prostate carcinogenesis.
Brooks
J D
JD
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
Bova
G S
GS
Isaacs
W B
WB
D000230:Adenocarcinoma / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D017353:Gene Deletion; D016161:Genes, Retinoblastoma; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011471:Prostatic Neoplasms / Q000235:genetics*