Lung functions after intravenous or intraperitoneal administration of perfluorooctyl bromide (PFOB) or perfluorotributylamine (FTBA) emulsions.
The biomechanical and oxygen transfer functions of lungs of animals administered intravenous or intraperitoneal fluorocarbon emulsions containing either perfluorotributylamine or perfluorooctyl bromide 4 to 7 days earlier were tested in a porcine and a canine model. Lung fluorocarbon content was measured by 19F NMR spectroscopy. The existence of fluorocarbon in the lung tissue produced no measurable effects on lung compliance variables in vivo or ex vivo nor on steady state oxygen transfer from air to blood over a wide range of inspired oxygen partial pressures.
Department of Pharmacology and Cell Biophysics University of Cincinnati, Ohio 45267-0575.
R W
RW
Millard
A J
AJ
McGoron
D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D004285:Dogs; D004655:Emulsions; D005466:Fluorocarbons / Q000494:pharmacology*; D006842:Hydrocarbons, Brominated; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D015656:Respiratory Mechanics; D013552:Swine
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C008807:perfluorotributylamine; C003072:perflubron