Ondansetron fails to attenuate a scopolamine-induced deficit in a Stone maze task.
The 5-HT3 receptor antagonist ondansetron has previously been reported to improve cognition in the mouse, rat and marmoset in a variety of behavioural paradigms. The present study used the Stone maze to test the effect of ondansetron on the deficit caused by scopolamine in the performance of a highly complex spatial memory task in the rat. Ondansetron administered over a large dose range (1.0 ng kg-1-1.0 micrograms kg-1, i.p., b.d.) for a period of 10-15 days failed to attenuate the scopolamine deficit. Indeed at one dose level ondansetron (100 ng kg-1, i.p., b.d.) administered in combination with scopolamine (0.5 mg kg-1, i.p.) significantly potentiated the deficit, compared with the performance of rats receiving scopolamine alone.
School of Pharmacy, University of Bradford, West Yorkshire, UK.
A M
AM
Bratt
M E
ME
Kelly
A M
AM
Domeney
R J
RJ
Naylor
B
B
Costall
D000818:Animals; D003071:Cognition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects; D017294:Ondansetron / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000037:antagonists & inhibitors*; D013028:Space Perception / Q000187:drug effects
D017294:Ondansetron; D012601:Scopolamine