A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.
Exonuclease I (Exo I) from Schizosaccharomyces pombe, a 5'-->3' double-stranded DNA exonuclease, is induced during meiotic prophase I. The exo1 gene is a member of a family of related DNA repair genes, including RAD2/rad13/xpgc and YKL510/rad2, conserved from yeast to humans. An exo1 mutant displays a mutator phenotype and alters activity of the ade6-M387 marker effect. These results suggest that Exo I acts in a pathway that corrects mismatched base pairs.
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
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D000483:Alleles; D000595:Amino Acid Sequence; D001482:Base Composition; D001483:Base Sequence; D003433:Crosses, Genetic; D004260:DNA Repair; D004261:DNA Replication; D004271:DNA, Fungal / Q000378:metabolism*; D005090:Exodeoxyribonucleases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008540:Meiosis; D008969:Molecular Sequence Data; D009154:Mutation; D011995:Recombination, Genetic; D012568:Schizosaccharomyces / Q000201:enzymology / Q000235:genetics* / Q000502:physiology
D004271:DNA, Fungal; D005090:Exodeoxyribonucleases; C028450:exodeoxyribonuclease I