Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy.
Proton magnetic resonance spectroscopic imaging (1H MRSI) has demonstrated decreased N-acetyl compounds (NA) in the epileptogenic hippocampus in patients with temporal lobe epilepsy. We studied 8 patients with frontal lobe epilepsy and found mean NA/creatine (Cr) in the epileptogenic frontal lobe decreased by 27% compared with that of the contralateral homologous region (1.81 +/- 0.36 vs 2.49 +/- 0.60, p < 0.008). In every patient, NA/Cr was decreased in the epileptogenic region by at least 5%. These findings suggest that 1H MRSI may be useful in the presurgical evaluation of patients with frontal lobe epilepsy.
Garcia
P A
PA
Department of Neurology, University of California, San Francisco 94143.
Laxer
K D
KD
van der Grond
J
J
Hugg
J W
JW
Matson
G B
GB
Weiner
M W
MW
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011300:Preoperative Care; D011522:Protons
D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline