Linkage of a new locus for autosomal dominant familial spastic paraplegia to chromosome 2p.
Autosomal dominant familial spastic paraplegia (AD-FSP) is a genetically heterogeneous neurodegenerative disorder characterized by a spasticity of the lower limbs. A locus causing AD-FSP (FSP1) has been previously mapped to chromosome 14q. We now report linkage of a second AD-FSP locus (FSP2) to chromosome 2p21-p24 in five of seven French families and one large Dutch pedigree. The analysis of recombination events and multipoint linkage place FSP2 within a 4 cM interval flanked by loci D2S400 and D2S367.
Hazan
J
J
Unité de Génétique Moléculaire Humaine, CNRS URA 1445, Institut Pasteur, Paris, France.
Fontaine
B
B
Bruyn
R P
RP
Lamy
C
C
van Deutekom
J C
JC
Rime
C S
CS
Dürr
A
A
Melki
J
J
Lyon-Caen
O
O
Agid
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D004247:DNA / Q000235:genetics; D005260:Female; D005602:France; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010375:Pedigree; D011995:Recombination, Genetic; D015419:Spastic Paraplegia, Hereditary / Q000235:genetics*
D005819:Genetic Markers; D004247:DNA