Xenotransplantation and its future.
Today at the beginning of the era of xenotransplantation, only simple and single observations about comparative physiology, biochemistry and anatomy are known. In addition, very few data exist which inform about the mechanisms after successful xenotransplantation. Nothing is known about the phenomena following successfully suppressed hyperacute xenogeneic rejection (HXR). Neither the elimination of a single factor nor the mitigation of whole systems has led to clinically relevant survival times (SVT). Pig organs transplanted into non-human primates survived a maximum of 22 days. The hope that transgenic manipulation and modification would be useful in prolonging the SVT of xenogeneic grafts still awaits supporting evidence. But within a short time, xenotransplantation could enable patients to receive a life saving animal organ as an alternative to an allograft. Xenotransplantation would, as a new dimension in medicine, shorten if not eliminate waiting lists. Therefore, scientists must vigorously develop xenografting as a viable alternative to allotransplantation. Xenotransplantation would not be the terrible danger that some individuals proclaim, and would also not simply be the extension of transplantation but would rather be a victory in medical research.
Institute for Surgical Research, Klinikum Gross-hadern, LMU München, Germany.
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D000818:Animals; D005544:Forecasting; D006801:Humans; D013045:Species Specificity; D014022:Tissue Survival; D014183:Transplantation, Heterologous / Q000639:trends