Histidine and aspartate phosphorylation: two-component systems and the limits of homology.
Autophosphorylating histidine kinase and response-regulator domains constitute the building blocks of two-component signaling systems. These systems use a unique phosphotransfer chemistry to regulate many aspects of bacterial physiology. Homologous systems are now being found in eukaryotes. Despite their common mechanism of phosphotransfer, the two-component systems display an extensive diversity in the arrangement of their domains, and flexibility in their roles in different signal transduction circuits.
Swanson
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Division of Biology, California Institute of Technology, Pasadena 91125.
Alex
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Simon
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D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism*; D010766:Phosphorylation; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology
D001224:Aspartic Acid; D006639:Histidine