Peripheral blood concentrations of plasma steroids and a metabolite of prostaglandin F2 alpha in pregnant cows vaccinated against foot and mouth disease.
Blood samples were collected from 82 pregnant cows at 6-h intervals to determine the effects of vaccination against foot and mouth disease (FMD) on plasma concentrations of progesterone, total unconjugated oestrogens, total corticosteroids and 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM). Twenty-two (26.8%) cows showed a strong post-vaccinal reaction in the form of a significant (P < 0.05) elevation in rectal temperature, accompanied by significant (P < 0.01) increases in plasma progesterone and corticosteroid concentrations for 36-42 h after vaccination. Seven (8.5%) cows returned to oestrus within 5-6 days when vaccinated during the first month of pregnancy and nine (10.9%) gave birth prematurely within 72-80 h when vaccinated during the last month of gestation. The importance of post-vaccinal reactions on embryonic mortality and premature birth is emphasized. It is suggested that cows in early and late pregnancy are most susceptible to adverse effects of vaccination against FMD.
Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
M S
MS
el-Belely
H M
HM
Eissa
I M
IM
Ghoneim
D000818:Animals; D005537:Aphthovirus / Q000276:immunology; D001831:Body Temperature; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood* / Q000517:prevention & control; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D005536:Foot-and-Mouth Disease / Q000097:blood* / Q000517:prevention & control; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D012098:Reproduction; D013256:Steroids / Q000097:blood*; D013312:Stress, Physiological / Q000097:blood / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage
D013256:Steroids; D014765:Viral Vaccines; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D015237:Dinoprost