The angiotensin I-converting enzyme gene polymorphism: implication in hypertension and myocardial infarction.
The angiotensin I-converting enzyme gene is one of the major genes of the renin-angiotensin and kallikrein-kinin systems and is a candidate gene for several cardiovascular diseases for which a genetic predisposition has been established. Based on analysis of the level of the enzyme in plasma, a genetic polymorphism of its expression has been well characterized. Use of a DNA marker on the angiotensin I-converting enzyme gene has shown that the gene polymorphism is located within the angiotensin I-converting enzyme gene itself. This review summarizes the results of various studies of this polymorphism in cardiovascular diseases and the hypotheses that can be proposed to explain this effect.
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INSERM, Paris, France.
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D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D009203:Myocardial Infarction / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D007703:Peptidyl-Dipeptidase A