Differentiation and patterning in Dictyostelium.
Dictyostelium development is orchestrated by diffusible signals. Progress has been made in understanding how cAMP signaling triggers post-aggregative development and in defining the number of cell types that eventually differentiate. Ammonia is an unusual signal that may act by alkalinizing acidic vesicles. A chlorinated signal, differentiation-inducing factor (DIF), may be universal amongst the slime moulds. The first genes have been cloned using restriction enzyme mediated integration (REMI) insertional mutagenesis; one encodes a novel cytosolic protein essential for activation of adenylyl cyclase.
MRC Laboratory of Molecular Biology, Cambridge, UK.
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Kay
D000818:Animals; D002454:Cell Differentiation; D000242:Cyclic AMP / Q000378:metabolism; D004023:Dictyostelium / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D005800:Genes, Fungal; D017125:Genes, Protozoan; D016296:Mutagenesis; D015398:Signal Transduction
D000242:Cyclic AMP