Mucosal immune responses in calves orally vaccinated with a live auxotrophic aroA Salmonella dublin strain.
The mucosal immune responses were studied in two calves orally vaccinated with the live aroA mutant strain, Salmonella dublin SL5631, and in two non-vaccinated control calves. Intestinal secretions were collected through a permanent fistula in place during a 5-week period. Vaccinated calves responded with high IgM and IgA titres against the S. dublin lipopolysaccharide. Both IgA and the IgM titres appeared already after 3 days and IgM somewhat earlier than the IgA titres. Both antibody titres remained high for 2 weeks after the third and final vaccine dose. The calves also showed marked T-cell responses in lymphocytes collected from mesenterial lymph nodes and the spleen.
National Veterinary Institute, Uppsala, Sweden.
T
T
Segall
S O
SO
Jacobsson
K
K
Karlsson
A A
AA
Lindberg
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D005260:Female; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000276:immunology*; D008297:Male; D012475:Salmonella / Q000235:genetics / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary
D001428:Bacterial Vaccines; D007136:Immunoglobulins