[Nooptropic agents and their action mechanisms in relation to neuropathology in senile dementia. II. Disorders of membrane integrity and neuron metabolism].
The author discusses several newer aspects concerning neurodegenerative processes in nerve cells of aging brain on the level of membrane integrity and neuronal metabolism disturbances: aggressive impact of free radicals and excitatory amino acids, loss of calcium homeostasis, deposition of amyloid proteins. Perspective nootropic agents are presented which were synthetized with the aim to regulate these deficits and first clinical experience with their administration in senile dementia patients is evaluated.
Benesová
O
O
Psychiatrické Centrum Praha.
D000375:Aging / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000682:Amyloid / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003704:Dementia / Q000503:physiopathology*; D005609:Free Radicals / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D018697:Nootropic Agents / Q000494:pharmacology*
D000596:Amino Acids; D000682:Amyloid; D005609:Free Radicals; D018697:Nootropic Agents; D002118:Calcium
Nootropní látky a jejich mechanismus úcinku ve vztahu k neuropatobiologii senilní demence. II. Poruchy membránové integrity a metabolismu neuronů.