Uptake of 99mTc-exametazime shown by single photon emission computerized tomography in obsessive-compulsive disorder compared with major depression and normal controls.
Twelve patients with obsessive-compulsive disorder (OCD) were investigated at rest using single photon emission computerized tomography with 99mTc-exametazime. The uptake of 99mTc-exametazime was expressed relative to calcarine/occipital cortex. Patients were matched for drug treatment with 12 patients with a major depressive episode and the patient groups were compared with a control group. Significant bilateral decreases in tracer uptake were confined to basal ganglia in the OCD group. There was a paradoxical positive correlation between anxiety ratings and tracer uptake to basal ganglia in the OCD group. The findings confirm that the functional topography of OCD implicates altered function in the basal ganglia.
Edmonstone
Y
Y
Cullen Centre, Royal Edinburgh Hospital, Morningside Park, United Kingdom.
Austin
M P
MP
Prentice
N
N
Dougall
N
N
Freeman
C P
CP
Ebmeier
K P
KP
Goodwin
G M
GM
D000328:Adult; D001008:Anxiety Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D003866:Depressive Disorder / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D015609:Organotechnetium Compounds; D010091:Oximes; D011619:Psychotropic Drugs / Q000627:therapeutic use; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D010091:Oximes; D011619:Psychotropic Drugs; D019690:Technetium Tc 99m Exametazime