Similarities in response to fluoxetine in the treatment of children and adolescents with obsessive-compulsive disorder.
OBJECTIVE
Obsessive-compulsive disorder (OCD) is a relatively common disorder that frequently has its onset in childhood and is associated with substantial morbidity and dysfunction despite availability of new treatments. However, antiobsessional agents have not been systematically evaluated in young children and their effectiveness beyond the short term has not been well studied. The purpose of this study was to evaluate the usefulness of fluoxetine in the long-term treatment of both children and adolescents with OCD.


METHODS
All pediatric patients with a DSM-III-R diagnosis of OCD who were treated with fluoxetine were ascertained from retrospective chart reviews of a pediatric psychopharmacology clinic. Response to treatment was evaluated by experienced clinicians using the Clinical Global Impression Scale.


RESULTS
Of 38 identified patients, 28 (74%) showed moderate to marked improvement of OCD symptoms on doses averaging 50 mg/day (1.0 mg/kg per day) over an average follow-up period of 19 months. Similar effects were observed in children and adolescents.


CONCLUSIONS
Although limited by their retrospective nature, these findings indicate that fluoxetine may be effective in prepubertal children and that the effect can be sustained over time.
Joint Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston.
D A
DA
Geller
J
J
Biederman
E D
ED
Reed
T
T
Spencer
T E
TE
Wilens
D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000150:complications / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy*
D000929:Antidepressive Agents, Tricyclic; D005473:Fluoxetine