Curcacycline A--a novel cyclic octapeptide isolated from the latex of Jatropha curcas L.
From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly1-Leu2-Leu3-Gly4-Thr5-Val6-Leu7-Leu8-Gly1+ ++. Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.
Department of Pharmacognosy, Faculty of Pharmacy, Universiteit Utrecht, The Netherlands.
A J
AJ
van den Berg
S F
SF
Horsten
J J
JJ
Kettenes-van den Bosch
B H
BH
Kroes
C J
CJ
Beukelman
B R
BR
Leeflang
R P
RP
Labadie
D000595:Amino Acid Sequence; D002455:Cell Division / Q000187:drug effects; D003171:Complement Pathway, Classical / Q000187:drug effects; D006801:Humans; D007840:Latex / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010940:Plant Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
D007840:Latex; D010456:Peptides, Cyclic; D010940:Plant Proteins; C091788:curcacyline A