The role of a transient potassium current in a bursting neuron model.
Presented here is a biophysical cell model which can exhibit low-frequency repetitive activity and bursting behavior. The model is developed from previous models (Av-Ron et al. 1991, 1993) for excitability, oscillations and bursting. A stepwise development of the present model shows the contribution of a transient potassium current (IA) to the overall dynamics. By changing a limited set of model parameters one can describe different firing patterns; oscillations with frequencies ranging from 2-200 Hz and a wide range of bursting behaviors in terms of the durations of bursting and quiescence, peak firing frequency and rate of change of the firing frequency.
Groupe de Bioinformatique, URA 686 - Ecole Normale Supérieure, Paris, France.
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Av-Ron
D000818:Animals; D008959:Models, Neurological; D008962:Models, Theoretical; D009474:Neurons / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology*
D015221:Potassium Channels