A review of the carcinogenicity of chemicals most frequently found at National Priorities List sites.
Several studies have shown that numerous National Priorities List (NPL) sites have been contaminated with arsenic (747), cadmium (791), chloroform (596), or nickel (664). The National Toxicology Program (NTP, 1991) has classified these substances as known human carcinogens (arsenic and certain arsenic compounds) or as substances that may reasonably be anticipated to be carcinogens (cadmium and certain cadmium compounds, chloroform, and nickel and certain nickel compounds). The general population is probably exposed to low levels of these hazardous substances through drinking water, eating food, or inhaling contaminated air. People working or living near industries and facilities that manufacture and use chloroform, nickel, arsenic, or cadmium may be exposed to higher than background levels of these hazardous substances. Multiple pathways of exposure may exist for populations near hazardous waste sites. For example, high levels of chloroform (1,890 ppb) were found in well water near a waste site; high levels of cadmium exposure may exist for individuals living near cadmium-contaminated waste sites.
Division of Toxicology, U.S. Department of Health and Human Services Atlanta, Georgia.
O M
OM
Faroon
M
M
Williams
R
R
O'Connor
D000818:Animals; D001151:Arsenic / Q000009:adverse effects; D002104:Cadmium / Q000009:adverse effects; D002273:Carcinogens; D002725:Chloroform / Q000009:adverse effects; D004326:Drinking; D005260:Female; D006256:Hazardous Waste; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced*; D009532:Nickel / Q000009:adverse effects; D016273:Occupational Exposure / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000139:chemically induced; D051381:Rats; D012307:Risk Factors; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
D002273:Carcinogens; D006256:Hazardous Waste; D014874:Water Pollutants, Chemical; D002104:Cadmium; D009532:Nickel; D002725:Chloroform; D001151:Arsenic