[Why are some allergens enzymes?].
In the last ten years, progress in the field of allergy research has led to the purification of some of the major allergens and to a better knowledge of their physico-chemical properties. A number of studies have shown that some allergens have enzymatic activities. Molecular biology has provided the means to clone and sequence genes encoding these allergens and to produce recombinant allergens in yeast and bacteria. Epitope mapping of natural and synthetic allergens, using polyclonal or monoclonal antibodies and cell-stimulation tests, has also contributed greatly to the understanding of their immunogenicity and allergenicity. Analysis of these new data allow us to explain why some allergens are enzymes.
Service de médecine et d'allergologie, hôpital Rothschild, Paris, France.
M H
MH
Chabane
N
N
Abuaf
F
F
Leynadier
D000053:Acari / Q000201:enzymology; D000485:Allergens / Q000145:classification* / Q000378:metabolism; D000818:Animals; D004391:Dust; D004798:Enzymes / Q000276:immunology* / Q000378:metabolism
D000485:Allergens; D004391:Dust; D004798:Enzymes
Pourquoi certains allergènes sont-ils des enzymes?