Familial levodopa-responsive parkinsonian-pyramidal syndrome.
We present four patients--two pairs of siblings--followed for many years, with pyramidal and parkinsonian features, who responded consistently to levodopa therapy. The patients belong to two unrelated consanguineous families, suggesting that this condition is genetically determined and recessively inherited.
Nisipeanu
P
P
Department of Neurology, Tel-Aviv Sourasky Medical Center, Ramat Aviv, Israel.
Kuritzky
A
A
Korczyn
A D
AD
D000293:Adolescent; D000328:Adult; D001480:Basal Ganglia Diseases / Q000188:drug therapy / Q000235:genetics*; D002230:Carbidopa / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics*; D010375:Pedigree
D007980:Levodopa; D002230:Carbidopa