Activated lymphocytes in glioblastoma: significance for anti-tumoral immunity.
Interaction between immune cells and tumoral cells of a case of glioblastoma was studied. Tissue fragments obtained during neurosurgery from different areas of the tumor were examined before and after rIL-2 treatment in vitro. The same morphofunctional type of cells usually activated by rIL-2, which show antitumoral reactivity, was observed both in the glioblastoma imprints and in tumoral fragments cultured with rIL-2. This cytokine stimulated the proliferation of tumor infiltrating lymphocytes in vitro. This preliminary study shows that IL-2 potentiates the differentiation of HMS cells in peripheral blood which probably pass through the blood brain barrier and infiltrate the tumor.
Lorusso
L
L
Fond. Istit. Neurol. C. Mondino, Univ. di Pavia.
Nano
R
R
Capelli
E
E
Marinu-Aktipi
K
K
Benericetti
E
E
Giardini
G
G
Ceroni
M
M
D000368:Aged; D014408:Biomarkers, Tumor; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology; D002283:Carcinoma, Bronchogenic / Q000276:immunology / Q000473:pathology; D005260:Female; D005909:Glioblastoma / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000494:pharmacology; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D016246:Lymphocytes, Tumor-Infiltrating / Q000187:drug effects / Q000276:immunology*; D008654:Mesothelioma / Q000276:immunology / Q000473:pathology; D011994:Recombinant Proteins / Q000494:pharmacology; D013702:Temporal Lobe; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D007376:Interleukin-2; D011994:Recombinant Proteins