Radiopharmaceuticals and the gastrointestinal tract.
A review is presented of the design of radiolabelled test meals for the evaluation of gastrointestinal function, including oesophageal transit, gastro-oesophageal reflux, gastric emptying, enterogastric reflux and transit through the whole bowel. Descriptions of different systems are presented, together with validations of the procedures used. Published methods for assessment of oesophageal transit show a marked degree of consistency, whereas gastric emptying studies employ a wide range of both liquid and solid test meals. Recommendations are made concerning the optimal system for investigation of each part of the gastrointestinal tract, but whichever system is adopted, it is important to employ some validation procedures, and to establish normal ranges in the population under study.
Department of Medical Physics, Queens Medical Centre, University Hospital Nottingham NHS Trust, UK.
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M
Frier
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Perkins
D001655:Bile Reflux / Q000000981:diagnostic imaging; D004064:Digestive System / Q000000981:diagnostic imaging*; D004383:Duodenogastric Reflux / Q000000981:diagnostic imaging; D004947:Esophagus / Q000000981:diagnostic imaging* / Q000502:physiology; D005502:Food; D005746:Gastric Emptying / Q000502:physiology; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging; D005769:Gastrointestinal Motility / Q000502:physiology; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D010528:Peristalsis / Q000502:physiology; D011849:Radioactive Tracers; D011877:Radionuclide Imaging
D011849:Radioactive Tracers