Effect of hormone replacement therapy on bone and lipid metabolism in women oophorectomized for the treatment of gynecologic malignancies.
OBJECTIVE
Our purpose was to evaluate the effects of hormone replacement therapy (HRT) on bone and lipid metabolism in women oophorectomized for the treatment of gynecologic malignancies.


METHODS
Bone mineral density (BMD), bone metabolic markers, sex hormones and lipoproteins were measured in three groups of age- and body mass-matched subjects. The subjects consisted of HRT(+) patients, i.e. those given HRT after oophorectomy (n = 39), HRT(-) patients, who received no HRT (n = 15), and controls comprising premenopausal women with no history of oophorectomy (n = 36).


RESULTS
BMD decreased significantly in the HRT(-) patients, but no decrease in BMD was observed in the controls or HRT(+) patients. HRT was effective in preventing bone loss by reducing high-turnover osteopenia. HRT reversed the negative trends in lipoprotein profiles by lowering low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol. There were no serious side effects or recurrences among the HRT(+) patients.


CONCLUSIONS
HRT appeared to have beneficial effects on bone and lipid metabolism in oophorectomized patients treated for gynecologic malignancies.
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
M
M
Yasuda
T
T
Kurabayashi
Y
Y
Yamamoto
T
T
Fujimaki
K
K
Oda
K
K
Tanaka
D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015914:Estrogen Replacement Therapy; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000601:surgery*; D010052:Ovariectomy; D017697:Premenopause; D014594:Uterine Neoplasms / Q000601:surgery*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004966:Estrogens, Conjugated (USP); D012739:Gonadal Steroid Hormones; D008074:Lipoproteins; D017258:Medroxyprogesterone Acetate