Aerosol delivery of antibiotics to the lower airways of patients with cystic fibrosis.
Aerosolized tobramycin is well tolerated in children and adults with cystic fibrosis (CF). It represents a potential alternative to intravenous administration of antibiotics to control respiratory infection with Pseudomonas aeruginosa. Although its exact role in acute therapy for a CF exacerbation is not known, it has been shown to improve lung function and reduce the frequency of exacerbations in the chronic stable outpatient.
Pulmonary and Critical Care Division, Medical College of Pennsylvania, Philadelphia.
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Fiel
D000280:Administration, Inhalation; D000336:Aerosols; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D016032:Randomized Controlled Trials as Topic; D014031:Tobramycin / Q000008:administration & dosage* / Q000627:therapeutic use*
D000336:Aerosols; D014031:Tobramycin