Effect of topical vasodilators on internal mammary arteries.
The internal mammary artery (IMA) is the conduit of choice for grafting the left anterior descending artery. However, arterial spasm and reduced early flow has been a cause of postoperative morbidity. The purpose of this study is to evaluate the effect of vasodilators on IMA flow. Fifty patients who had the IMA harvested in preparation for bypass grafting were studied. The IMA was mobilized from the subclavian vein to below the bifurcation of the IMA. The artery was prepared for grafting at least 3 cm proximal to the bifurcation. The IMA was allowed to bleed freely, and flow was determined (flow 1). The patients were divided into five groups: group I (n = 10) had 10 mL of saline solution applied topically to the IMA; group II had topical papaverine (5 mg/10 mL normal saline solution) applied to the IMA; group III had nitroglycerin (5 mg/10 mL normal saline solution) applied to the IMA, group IV had sodium nitroprusside (2.5 mg/10 mL) applied to the pedicle, and group V had 5 mL of papaverine mixed in 5 mL of saline solution injected into the periarterial tissues of the IMA pedicle. Before cardiopulmonary bypass, the flows were remeasured (flow 2). With each measurement, hemodynamic parameters were recorded. The time between measurements was recorded. There was no difference in blood pressure or pulse at the time of measurement.(ABSTRACT TRUNCATED AT 250 WORDS)
Sasson
L
L
Department of Cardiovascular Surgery, Edith Wolfson Medical Center, Holon, Israel.
Cohen
A J
AJ
Hauptman
E
E
Schachner
A
A
D000287:Administration, Topical; D001783:Blood Flow Velocity; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008323:Mammary Arteries / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D014665:Vasodilator Agents; D009599:Nitroprusside; D010208:Papaverine; D005996:Nitroglycerin