Analysis of clinical complication data for radiation hepatitis using a parallel architecture model.
OBJECTIVE
The detailed knowledge of dose volume distributions available from the three-dimensional (3D) conformal radiation treatment of tumors in the liver (reported elsewhere) offers new opportunities to quantify the effect of volume on the probability of producing radiation hepatitis. We aim to test a new parallel architecture model of normal tissue complication probability (NTCP) with these data.


METHODS
Complication data and dose volume histograms from a total of 93 patients with normal liver function, treated on a prospective protocol with 3D conformal radiation therapy and intraarterial hepatic fluorodeoxyuridine, were analyzed with a new parallel architecture model. Patient treatment fell into six categories differing in doses delivered and volumes irradiated. By modeling the radiosensitivity of liver subunits, we are able to use dose volume histograms to calculate the fraction of the liver damaged in each patient. A complication results if this fraction exceeds the patient's functional reserve. To determine the patient distribution of functional reserves and the subunit radiosensitivity, the maximum likelihood method was used to fit the observed complication data.


RESULTS
The parallel model fit the complication data well, although uncertainties on the functional reserve distribution and subunit radiosensitivity are highly correlated.


CONCLUSIONS
The observed radiation hepatitis complications show a threshold effect that can be described well with a parallel architecture model. However, additional independent studies are required to better determine the parameters defining the functional reserve distribution and subunit radiosensitivity.
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
A
A
Jackson
R K
RK
Ten Haken
J M
JM
Robertson
M L
ML
Kessler
G J
GJ
Kutcher
T S
TS
Lawrence
D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D016013:Likelihood Functions; D008099:Liver / Q000528:radiation effects*; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage