[Effect of E. coli endotoxin and D-galactosamine on pathophysiology in rat lungs].
The effects of repeated intravenous injection of E. coli endotoxin (ETX) and intraperitoneal injection of D-galactosamine (GAL), which decreases the circulating level of alpha 1-antitrypsin, on the pathophysiology of chronic lung injury was studied in rats. Four groups were prepared as follows for 8 weeks. Group 1 (control): Intravenous injection of saline. Group 2: Intravenous injection of ETX (2 mg/kg) once a week. Group 3: Intraperitoneal injection of GAL (200 mg/kg), 2 times daily on 3 consecutive days each week. Group 4: Injection of both ETX and GAL, at the same dosages as used in groups 2 and 3. Total lung capacity and static lung compliance divided by weight were high in the ETX group and the ETX + GAL group, comparative when compared with those in the control and GAL groups, even though weight gain rates in the ETX + GAL group was less than in other groups. Mean linear intercept of rats in the ETX + GAL group was significantly greater than in other groups. These results suggest that ETX + GAL-treated rats have more emphysematous changes in pulmonary function and structure.
Second Department of Internal Medicine, School of Medicine, Fukuoka University.
T
T
Aritomi
M
M
Yoshida
H
H
Toyoshima
H
H
Takihara
M
M
Ishibashi
K
K
Watanabe
D000818:Animals; D010450:Endopeptidases / Q000378:metabolism; D004731:Endotoxins / Q000008:administration & dosage; D004926:Escherichia coli; D005688:Galactosamine / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D011656:Pulmonary Emphysema / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D004731:Endotoxins; D000515:alpha 1-Antitrypsin; D005688:Galactosamine; D010450:Endopeptidases