title: Involution and cystic transformation of the thymus in the bottlenose dolphin, Tursiops truncatus.
abstract: The thymus glands of 10 bottlenose dolphins, Tursiops truncatus, collected along the Texas Gulf coast were examined using standard histologic and immunocytochemical methods. The thymus gland of Tursiops persists into adult life, represented by medulla and progressively thinning cortex. A network of epithelial cells, including Hassal bodies, is demonstrable using polyclonal anti-cytokeratin antibody. The network condenses, with loss of lymphoid cells as involution progresses. Cysts arise within the condensed network. These cysts, found in eight of 10 animals, increase in number and size with increasing body size. Body size tends to reflect age. Thymic cysts typically have an irregular shape when small but tend to become spherical as they enlarge. They may be lined by squamous epithelium of variable thickness. Eventually, the cysts become macroscopic and filled with a colloidlike material and may largely replace the thymus, which may be identified by noncystic remnants adjacent to the cysts.
authors.affiliation: Department of Pathology, University of Texas Medical Branch, Galveston.
authors.forename: D F
authors.initials: DF
authors.lastname: Cowan
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology; D000818:Animals; D004289:Dolphins / Q000033:anatomy & histology / Q000502:physiology; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D008476:Mediastinal Cyst / Q000473:pathology / Q000662:veterinary*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000473:pathology* / Q000502:physiology