title: Oxidative enzymes of polymorphonuclear leucocytes and plasma fibrinogen, ceruloplasmin, and copper levels in Behçet's disease.
abstract: This study was performed to investigate the antioxidant mechanisms of polymorphonuclear leucocytes (PMN) in active stage of Behçet's Disease. PMN activities of myeloperoxidase (p < 0.02), superoxide dismutase (p < 0.001), catalase (p < 0.005), and glutathione peroxidase (p < 0.005) were significantly lower in the patients: the NADPH oxidase activity was significantly higher (p < 0.001) than those in controls. The plasma levels of ceruloplasmin (Cp), fibrinogen, and copper (Cu) were also significantly higher in the patients group (p < 0.001). Significant and positive correlations were found between the glutathione peroxidase and catalase activities (p < 0.001) and also between the plasma Cp and Cu levels (p < 0.001) in the patients group. However, no correlation was observed among the other enzyme activities. In the control group, a significantly positive correlation was present only between the plasma ceruloplasmin and Cu levels (p < 0.001). It was concluded that (impaired PMN functions) decreased enzyme activities in the antioxidant system and increased levels of oxygen free radicals may play a role in tissue damage in Behçet's disease.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: P
authors.initials: P
authors.lastname: Doğan
authors.forename: G
authors.initials: G
authors.lastname: Tanrikulu
authors.forename: U
authors.initials: U
authors.lastname: Soyuer
authors.forename: K
authors.initials: K
authors.lastname: Köse
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000097:blood*; D002570:Ceruloplasmin / Q000378:metabolism*; D003300:Copper / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*
chemical_list: D003300:Copper; D005340:Fibrinogen; D010088:Oxidoreductases; D002570:Ceruloplasmin