title: Effect of intraarticular osmic acid on synovial membrane volume and inflammation, determined by magnetic resonance imaging.
abstract: The changes in MR-determined synovial membrane volume, early synovial enhancement, and cartilage and bone erosions after osmic acid knee synovectomy were studied. Gadolinium-DTPA enhanced magnetic resonance imaging (MRI) of 18 knees with persistent arthritis was performed before and 1 month after treatment. The synovial membrane volume was significantly reduced (median -52%) in all 9 patients brought into clinical remission (p < 0.01), while no significant change was found in patients with clinical relapse. The early synovial enhancement was not significantly changed. MRI revealed progressive erosive changes in 2 patients. The time of relapse was correlated to a MR-erosion score, but not to early synovial enhancement or volumes of synovium or effusion (Spearman tests). MRI-determined synovial membrane volumes and early synovial enhancement may be objective quantitative markers of inflammation. MR-scores of cartilage and bone erosions are sensitive to progressive changes occurring within a month.
authors.affiliation: Danish Research Center of Magnetic Resonance, Hvidovre Hospital, University of Copenhagen.
authors.forename: M
authors.initials: M
authors.lastname: Ostergaard
authors.forename: M
authors.initials: M
authors.lastname: Stoltenberg
authors.forename: P
authors.initials: P
authors.lastname: Gideon
authors.forename: S
authors.initials: S
authors.lastname: Wieslander
authors.forename: S
authors.initials: S
authors.lastname: Sonne-Holm
authors.forename: P
authors.initials: P
authors.lastname: Kryger
authors.forename: M
authors.initials: M
authors.lastname: Sonne
mesh_terms: D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D002356:Cartilage / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009993:Osmium Tetroxide / Q000008:administration & dosage*; D012008:Recurrence; D013583:Synovial Membrane / Q000187:drug effects* / Q000473:pathology; D013585:Synovitis / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
chemical_list: D009993:Osmium Tetroxide