title: Hemifacial spasm and osteitis deformans.
abstract: OBJECTIVE
  A patient with osteitis deformans (Paget's disease) and hemifacial spasm underwent magnetic resonance tomographic angiography. Bone-modulating bisphosphonates and botulinum injection were administered to treat the hemifacial spasm.
  
  
  CONCLUSIONS
  Computed tomography showed marked temporal bone overgrowth. Magnetic resonance tomographic angiography showed no vascular compression of the facial nerve root. The hemifacial spasm failed to resolve with intravenous pamidronate. Subsequent botulinum injection rendered the patient spasm free for 22 weeks. Further research on the use of bisphosphonates in the treatment of pagetoid hemifacial spasm is required.
authors.affiliation: Neuro-ophthalmology Service, Wills Eye Hospital, Philadelphia, PA 19107.
authors.forename: E B
authors.initials: EB
authors.lastname: Ing
authors.forename: P J
authors.initials: PJ
authors.lastname: Savino
authors.forename: T M
authors.initials: TM
authors.lastname: Bosley
authors.forename: R C
authors.initials: RC
authors.lastname: Sergott
authors.forename: N
authors.initials: N
authors.lastname: Kelepouris
mesh_terms: D000368:Aged; D001905:Botulinum Toxins / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D005147:Facial Bones / Q000473:pathology; D005152:Facial Muscles / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D010001:Osteitis Deformans / Q000150:complications*; D000077268:Pamidronate; D013035:Spasm / Q000150:complications* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D004164:Diphosphonates; D001905:Botulinum Toxins; D000077268:Pamidronate