title: Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: effect of drugs with different molecular mechanisms.
abstract: In the present study the authors investigated the effect of pretreatment with exogenous antioxidants such as deferoxamine (iron chelating drug), allopurinol (competitive inhibitor of xanthine oxidase) and vitamin E (scavenger of oxygen free radicals) on lipid peroxidation in rat cerebral cortex after post-ischaemic reperfusion, and on the survival rate. The effect of pretreatment with two calcium-antagonist drugs (diltiazem and verapamil) was also evaluated under the same experimental conditions. Pretreatment with exogenous antioxidants and with calcium-antagonist drugs significantly decreased cerebral conjugated diene levels (index of lipoperoxidation) with a concomitant increase in survival with respect to untreated ischaemic rats.
authors.affiliation: Institute of Biochemistry, Faculty of Pharmacy, University of Catania, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Sorrenti
authors.forename: C
authors.initials: C
authors.lastname: Di Giacomo
authors.forename: M
authors.initials: M
authors.lastname: Renis
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: C
authors.initials: C
authors.lastname: La Delfa
authors.forename: J R
authors.initials: JR
authors.lastname: Perez-Polo
authors.forename: A
authors.initials: A
authors.lastname: Vanella
mesh_terms: D000493:Allopurinol / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy*; D003676:Deferoxamine / Q000494:pharmacology / Q000627:therapeutic use; D004110:Diltiazem / Q000494:pharmacology / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion; D015427:Reperfusion Injury / Q000188:drug therapy; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D000493:Allopurinol; D014700:Verapamil; D004110:Diltiazem; D003676:Deferoxamine