Nortriptyline-induced fulminant hepatic failure.
We describe, to our knowledge, the first reported case of nortriptyline-induced fulminant hepatic failure. This tricyclic antidepressant drug was taken by a postmenopausal woman for 64 days before her presentation. The absence of fever, rash, or marked eosinophilia, the predominant zone 3 necrosis with bridging, and the latent period favor a metabolic idiosyncratic reaction. The fatal outcome underscores the importance of recognizing the association and discontinuing the offending agent.
Berkelhammer
C
C
Department of Medicine, Christ Hospital and Medical Center, Oak Lawn, Illinois 60453.
Kher
N
N
Berry
C
C
Largosa
A
A
D000368:Aged; D000369:Aged, 80 and over; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D017809:Fatal Outcome; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D009661:Nortriptyline / Q000009:adverse effects*
D009661:Nortriptyline