Effects of buspirone on influenza A virus infection in stressed mice.
Experiments were conducted to evaluate the effects of chronic buspirone (1 mg/kg/day) on the influenza A (PR-8/34) virus specific immune injury in CD-1 mice exposed to a chronic auditory stressor. Treatment with buspirone resulted in a decrease of the stress-induced increase of virus titers and pulmonary vascular permeability as well as in a reduction of the mortality of mice.
Freire-Garabal
M
M
NIMUS, Department of Pharmacology, School of Pharmacy, Universidad de Santiago de Compostela, Spain.
Núñez
M J
MJ
Losada
C
C
Pereiro
D
D
Castro-Bolaño
C
C
Gándara
J
J
Varela-Patiño
M P
MP
Rey-Méndez
M
M
D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D002199:Capillary Permeability; D007113:Immunity, Innate / Q000187:drug effects; D009980:Influenza A virus / Q000254:growth & development*; D008168:Lung / Q000821:virology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000276:immunology* / Q000821:virology; D011650:Pulmonary Alveoli / Q000098:blood supply; D011897:Random Allocation; D013312:Stress, Physiological / Q000150:complications*
D002065:Buspirone