[Anterior pituitary responsiveness in central Cushing disease and in Cushing syndrome caused by adrenal cortex tumors, as well as in simple obesity].
To evaluate whether the PRL, TSH and gonadotropin secretion is altered in conditions with elevated body mass index, 7 patients with central Cushing's disease before and after transsphenoidal surgery, 7 untreated patients with Cushing's syndrome caused by adrenal adenoma, 17 simplex obese (obese) women and 9 non-obese controls (all females, aged 18-45 years) were tested with TRH (200 micrograms i.v. bolus) and GnRH (100 micrograms i.v. bolus) and the hormone responses were measured. There were no differences in the basal pituitary hormone secretion among the groups. In obese subjects the PRL response was reduced as compared to untreated patients with corticotrop pituitary adenoma. No significant differences of TSH release could be observed among the groups, whereas serum total T4 levels were higher in obesity than in patients with hypercorticism either caused by pituitary or adrenal Cushing's syndrome. No differences were found in the LH response, but the stimulated FSH release was lower in obesity, in patients with central Cushing's disease after transsphenoidal surgery and in patients with primary Cushing's syndrome as compared to the normal controls.
Góth
M
M
I. Belgyógyászati Klinika, Haynal Imre Egészségtudományi Egyetem Budapest.
Szabolcs
I
I
Kovács
Z
Z
Szilágyi
G
G
D000233:Adenoidectomy; D000293:Adolescent; D018246:Adrenocortical Adenoma / Q000150:complications* / Q000601:surgery; D000328:Adult; D015992:Body Mass Index; D003480:Cushing Syndrome / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011184:Postoperative Period; D011388:Prolactin / Q000378:metabolism; D012636:Secretory Rate; D013972:Thyrotropin / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism
D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013972:Thyrotropin
A hypophysis mellsölebeny reakciókészsége centrális Cushing-kórban, mellékvesekéreg daganat okozta Cushing-syndromában és egyszerü elhízásban.