title: pS2--a new cytosolic protein recognized by monoclonal antibodies as a marker of hormone sensitivity in breast cancer.
abstract: Using a new immunoradiometric assay (ELSA pS2 Cis-France), a total of 200 cytosols obtained from primary breast tumors were examined for pS2 content, which is an estrogen-regulated protein actually studied as a marker of hormone sensitivity and favorable prognostic factor in breast cancer. In our patient group, the median pS2 value corresponding to 5.3 ng/mg of cytosolic proteins was used as cutoff. pS2 content was not related to menopause status, tumor size, or nodal involvement, whereas a positive correlation was found between pS2 and ER/PgR status. Moreover, the association of pS2 with steroid receptors seems to identify subgroups of patients better than ER/PgR alone.
authors.affiliation: RIA Laboratory, Oncology Institute of Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Correale
authors.forename: I
authors.initials: I
authors.lastname: Abbate
authors.forename: A
authors.initials: A
authors.lastname: Paradiso
authors.forename: F
authors.initials: F
authors.lastname: Schittulli
authors.forename: C D
authors.initials: CD
authors.lastname: Dragone
authors.forename: T
authors.initials: T
authors.lastname: Tedone
authors.forename: G
authors.initials: G
authors.lastname: Gargano
authors.forename: A M
authors.initials: AM
authors.lastname: Catino
authors.forename: M D
authors.initials: MD
authors.lastname: Musci
authors.forename: M
authors.initials: M
authors.lastname: De Lena
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D002277:Carcinoma / Q000175:diagnosis* / Q000503:physiopathology; D003600:Cytosol / Q000737:chemistry; D004967:Estrogens / Q000502:physiology; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity; D009363:Neoplasm Proteins / Q000097:blood / Q000276:immunology; D011379:Prognosis; D011506:Proteins; D011960:Receptors, Estrogen / Q000502:physiology; D011980:Receptors, Progesterone / Q000502:physiology; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D004967:Estrogens; D009363:Neoplasm Proteins; D011506:Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins