Ethosuximide enantiomers in pregnancy and lactation.
A gas-chromatographic method was used to determine plasma concentrations of the ethosuximide enantiomers during three pregnancies in two epileptic women, in samples from the umbilical cord in one, and in breast milk in two patients. The ratio of the two enantiomers of ethosuximide ranged from 1.00 to 1.36 and was apparently unaffected by pregnancy, passage into breast milk, and transfer over the placenta. Hence, determination of total ethosuximide concentrations appear to be sufficient for therapeutic drug monitoring during pregnancy and lactation.
Tomson
T
T
Department of Neurology, Söder Hospital, Stockholm, Sweden.
Villén
T
T
D000328:Adult; D002849:Chromatography, Gas / Q000379:methods; D016903:Drug Monitoring; D004827:Epilepsy / Q000097:blood*; D005013:Ethosuximide / Q000097:blood*; D005260:Female; D006801:Humans; D007536:Isomerism; D007774:Lactation; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*
D005013:Ethosuximide