Possible nutritional factors in induced pemphigus.
Today it is generally accepted that every drug that possesses an active thiol group in its molecule is capable of inducing pemphigus. Some plants, in particular those belonging to the Allium group, contain several active compounds with stable disulfide and thiol groups in their molecule. The Allium group contains many important vegetables like onion, leek and garlic. Examples of molecules with an active thiol group are: CH2 = CH-CH2-S-S-CH2-CH = CH2 (diallyl disulfide) or CH2 = CH-CH2-S(O)S-CH2-CH = CH2 (allicin). It is suggested that some foods, in particular vegetables of the Allium group that contain active thiol groups in their molecule, could contribute to the induction of pemphigus. In general, nutritional factors should be added to the list of exogenous factors that are capable of inducing pemphigus.
Brenner
S
S
Department of Dermatology, Ichilov Hospital, Tel Aviv, Israel.
Wolf
R
R
D000490:Allium / Q000737:chemistry; D000498:Allyl Compounds; D004220:Disulfides / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D009747:Nutritional Physiological Phenomena; D010392:Pemphigus / Q000209:etiology*; D013438:Sulfhydryl Compounds / Q000009:adverse effects* / Q000032:analysis; D013441:Sulfinic Acids / Q000009:adverse effects / Q000032:analysis; D014675:Vegetables / Q000009:adverse effects* / Q000737:chemistry
D000498:Allyl Compounds; D004220:Disulfides; D013438:Sulfhydryl Compounds; D013441:Sulfinic Acids; C006452:allicin; C028009:diallyl disulfide