Maturation and segregation of brain networks that modify seizures.
The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions which differ in the amount of mRNA expression of the GABAA receptor alpha 1 subunit. These two regions mediate separate anticonvulsant and proconvulsant effects and use divergent projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the alpha 1 subunit and only the proconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABAA-sensitive networks.
Moshé
S L
SL
Department of Neurology, Albert Einstein College of Medicine, Rose F. Kennedy Center, South, Bronx, NY 10461.
Brown
L L
LL
Kubová
H
H
Velísková
J
J
Zukin
R S
RS
Sperber
E F
EF
D000818:Animals; D001931:Brain Mapping; D006651:Histocytochemistry; D017403:In Situ Hybridization; D008297:Male; D009415:Nerve Net / Q000254:growth & development / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000235:genetics; D012640:Seizures / Q000378:metabolism / Q000503:physiopathology*
D012333:RNA, Messenger; D011963:Receptors, GABA-A