Lisinopril improves aortic compliance and renal flow. Comparison with nifedipine.
We compared the systemic and regional hemodynamic effects of nifedipine and lisinopril in 26 elderly hypertensive patients with the use of the pulsed Doppler ultrasound technique. Nifedipine is a dihydropyridine calcium antagonist, and lisinopril is an angiotensin-converting enzyme inhibitor. The study had a single-blind crossover design: nifedipine and lisinopril were given for 8 weeks each after washout periods of 4 weeks. Both nifedipine and lisinopril significantly reduced mean arterial pressure to the same extent (P < .01); cardiac output remained unchanged in both nifedipine- and lisinopril-treated groups. Lisinopril increased renal flow significantly (P < .01), but nifedipine did not. Common carotid, vertebral, celiac, and superior mesenteric arterial and diaphragmatic and terminal aortic flows did not show a significant change with either nifedipine or lisinopril. The specific action of lisinopril on the thoracic aorta was a marked improvement of aortic compliance compared with nifedipine, which might be partly responsible for an increase in renal flow. Lisinopril may provide more desirable regional hemodynamic effects and additional benefits for elderly hypertensive patients.
Shimamoto
H
H
Department of Cardiovascular Medicine, PIA Nakamura Hospital, Hiroshima, Japan.
Shimamoto
Y
Y
D000368:Aged; D001011:Aorta / Q000187:drug effects* / Q000502:physiology; D003187:Compliance; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D017706:Lisinopril / Q000494:pharmacology*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011674:Pulse; D012039:Regional Blood Flow / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects*; D012212:Rheology / Q000379:methods
D017706:Lisinopril; D009543:Nifedipine