title: Coagulation factor XIII in plasma of patients with benign and malignant gynaecological tumours.
abstract: Fibrinogen and factor XIII were measured in sixty-four women with recently detected gynaecological tumours. Twenty-six of these tumours were benign and 32 were malignant: of the last group, nine patients had metastases. No patient showed clinical signs of bleeding or thrombosis. A reference group consisted of 31 age-matched healthy women. For fibrinogen, no significant deviation between the patient groups and the control group was found. The median values of factor XIII were higher in the benign tumour group than in the control group. In patients with a gynaecological tumour and metastases, factor XIII was significantly lower than in the non-metastasized malignancy group or in the benign tumour group.
authors.affiliation: Department of Haematology, De Wever Hospital, Heerlen, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: van Wersch
authors.forename: C
authors.initials: C
authors.lastname: Peters
authors.forename: J M
authors.initials: JM
authors.lastname: Ubachs
mesh_terms: D000368:Aged; D001798:Blood Proteins / Q000378:metabolism; D005176:Factor XIII / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D001798:Blood Proteins; D005340:Fibrinogen; D005176:Factor XIII