title: T-cell co-receptors. The end of a frustrating search.
abstract: The identification of a 'silencer' element that turns off CD4 gene expression at specific states in thymocyte differentiation may help to resolve an important outstanding problem in immunology.
authors.affiliation: Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de l'Inserm, Institut de Chimie Biologique, Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Benoist
authors.forename: D
authors.initials: D
authors.lastname: Mathis
mesh_terms: D000818:Animals; D015704:CD4 Antigens / Q000235:genetics*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D015870:Gene Expression; D005809:Genes, Regulator; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
chemical_list: D015704:CD4 Antigens