title: Paracoccidioides brasiliensis-stimulated human gamma/delta T cells support antibody production by B cells.
abstract: Paracoccidioidomycosis patients show hyperactive humoral immune responses. Consequently, we investigated whether cytokines in supernatants from Paracoccidioides brasiliensis-stimulated gamma/delta T cells support B-cell activation. We detected proliferation of B cells and increased immunoglobulin M (IgM) and IgG production. Thus, gamma/delta T cells may participate in polyclonal B-cell activation during paracoccidioidomycosis.
authors.affiliation: Department of Immunology, University of Ulm, Germany.
authors.forename: M E
authors.initials: ME
authors.lastname: Munk
authors.forename: R A
authors.initials: RA
authors.lastname: Fazioli
authors.forename: V L
authors.initials: VL
authors.lastname: Calich
authors.forename: S H
authors.initials: SH
authors.lastname: Kaufmann
mesh_terms: D000908:Antibodies, Fungal / Q000096:biosynthesis; D000917:Antibody Formation; D000946:Antigens, Fungal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D010228:Paracoccidioides / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D016692:Receptors, Antigen, T-Cell, gamma-delta