title: Intravenous iron therapy for severe anaemia in systemic-onset juvenile chronic arthritis.
abstract: The role of iron supplementation in treating the anaemia of systemic-onset juvenile chronic arthritis is not clear. Eight affected children with severe persistent anaemia unresponsive to oral iron therapy were treated with intravenous iron saccharate. From a median post-oral-iron value of 8.0 g/dL (range 6.5-9.5), haemoglobin rose to 11.0 g/dL (10.1-12.1) (p = 0.01). The concentration of serum transferrin receptor, an indicator of iron deficiency, before intravenous therapy correlated with the increase in haemoglobin (r = 0.88, p < 0.01). Intravenous iron saccharate could be an effective treatment for chronic anaemia in this condition, especially with iron deficiency not responsive to oral iron.
authors.affiliation: Clinica Pediatrica, University of Pavia, IRCCS San Matteo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Martini
authors.forename: A
authors.initials: A
authors.lastname: Ravelli
authors.forename: G
authors.initials: G
authors.lastname: Di Fuccia
authors.forename: V
authors.initials: V
authors.lastname: Rosti
authors.forename: M
authors.initials: M
authors.lastname: Cazzola
authors.forename: G
authors.initials: G
authors.lastname: Barosi
mesh_terms: D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000209:etiology; D001171:Arthritis, Juvenile / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage*; D011990:Receptors, Transferrin / Q000032:analysis
chemical_list: D006454:Hemoglobins; D011990:Receptors, Transferrin; D007501:Iron