title: Theory of NMR signal behavior in magnetically inhomogeneous tissues: the static dephasing regime.
abstract: This paper is devoted to a theory of the NMR signal behavior in biological tissues in the presence of static magnetic field inhomogeneities. We have developed an approach that analytically describes the NMR signal in the static dephasing regime where diffusion phenomena may be ignored. This approach has been applied to evaluate the NMR signal in the presence of a blood vessel network (with an application to functional imaging), bone marrow (for two specific trabecular structures, asymmetrical and columnar) and a ferrite contrast agent. All investigated systems have some common behavior. If the echo time TE is less than a known characteristic time tc for a given system, then the signal decays exponentially with an argument which depends quadratically on TE. This is equivalent to an R2* relaxation rate which is a linear function of TE. In the opposite case, when TE is greater than tc, the NMR signal follows a simple exponential decay and the relaxation rate does not depend on the echo time. For this time interval, R2* is a linear function of a) volume fraction sigma occupied by the field-creating objects, b) magnetic field Bo or just the objects' magnetic moment for ferrite particles, and c) susceptibility difference delta chi between the objects and the medium.
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University Medical School, St. Louis, Missouri 63110.
authors.forename: D A
authors.initials: DA
authors.lastname: Yablonskiy
authors.forename: E M
authors.initials: EM
authors.lastname: Haacke
mesh_terms: D001808:Blood Vessels / Q000033:anatomy & histology*; D001853:Bone Marrow / Q000033:anatomy & histology*; D003287:Contrast Media; D005290:Ferric Compounds; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide