The effect of X-radiation on reticulo-endothelial system and its treatment with radiodetoxified-endotoxin and trace elements in rats.
A new in vivo method has been developed for the precise observation of RES activity. Both Escherichia coli endotoxin 100 micrograms/100 g i.v. (LPS) and radiodetoxified endotoxin 100 micrograms/100 g body weight i.v. (RD-LPS, TOLERIN) both increased the granulopectic activity of RES. The RD-LPS was more effective. The preparation containing trace elements also increased the activity of RES. The treatment consisting of the use of both trace elements and RD-LPS proved to be the most effective. The activity of RES was inversely proportional to various doses of X-ray irradiation (7, 8, 9 Gy). Trace elements and RD-LPS even improved the immunity system of animals having deteriorated RES.
Gál
K
K
Fréderic Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
Bertók
L
L
D000818:Animals; D004731:Endotoxins / Q000627:therapeutic use*; D005260:Female; D012157:Mononuclear Phagocyte System / Q000528:radiation effects*; D010587:Phagocytosis / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D013668:Technetium Tc 99m Aggregated Albumin / Q000378:metabolism; D014131:Trace Elements / Q000627:therapeutic use*
D004731:Endotoxins; D013668:Technetium Tc 99m Aggregated Albumin; D014131:Trace Elements