title: [Experimental study on compatible application of heat-clearing and detoxifying drugs with blood circulation improving drugs].
abstract: The article describes the effectiveness of compatible application of heat-clearing and detoxifying drugs with blood circulation improving drugs to the animal model with endotoxemia and nonspecific inflammation. The compatible application reduces PGE2, endotoxin blood concentration and reduced viscosity of whole blood, decreases Evans blue extravasation volume and pes swelling percentage, increases serum cortisol content and enhances fibrinolytic activity. The experimental result shows that in most cases these two drugs work better when used in combination which implies that compatible application is more effective in detoxification, antiinflammation and inflammation recovery.
authors.affiliation: Beijing University of Traditional Chinese Medicine, Dong Zhemen Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Ren
authors.forename: C S
authors.initials: CS
authors.lastname: Song
authors.forename: X H
authors.initials: XH
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.forename: J F
authors.initials: JF
authors.lastname: Gao
authors.forename: X D
authors.initials: XD
authors.lastname: He
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D015232:Dinoprostone / Q000097:blood; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004731:Endotoxins / Q000097:blood; D004926:Escherichia coli; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007249:Inflammation / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014115:Toxemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D015232:Dinoprostone; D006854:Hydrocortisone