title: Effect of dose and field strength on enhancement with paramagnetic contrast media.
abstract: OBJECTIVE
  To compare contrast enhancement per unit of dose of contrast medium in MR imaging at 0.5 and 1.5 T.
  
  
  METHODS
  Contrast enhancement in images made at 0.5 and 1.5 T after 0.1 mmol/kg of gadopentetate dimeglumine and 0.3 mmol/kg of gadodiamide was measured and the degree of contrast enhancement in the cavernous sinus and pituitary gland compared.
  
  
  RESULTS
  At both field strengths and both contrast medium doses, contrast enhancement was noted in the cavernous sinus, pituitary gland, infundibulum, maxillary sinus mucosa, falx cerebri, and choroid plexus on inspection of images. Enhancement was significantly and conspicuously less in the cavernous sinus and pituitary gland at 0.5 T (96% and 33%, respectively) than at 1.5 T (160% and 102%, respectively). No tissues were identified that enhanced only with the larger dose or higher field strength.
  
  
  CONCLUSIONS
  In tissues that normally enhance after intravenous administration of gadolinium chelates, enhancement is greater at 1.5 T than at 0.5 T.
authors.affiliation: Department of Radiology, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: R O
authors.initials: RO
authors.lastname: Lindsey
authors.forename: F Z
authors.initials: FZ
authors.lastname: Yetkin
authors.forename: R
authors.initials: R
authors.lastname: Prost
authors.forename: V M
authors.initials: VM
authors.lastname: Haughton
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D002426:Cavernous Sinus / Q000473:pathology; D002831:Choroid Plexus / Q000473:pathology; D003287:Contrast Media; D004338:Drug Combinations; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008443:Maxillary Sinus / Q000473:pathology; D008536:Meglumine; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000175:diagnosis
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; C064925:gadodiamide; D019786:Gadolinium DTPA