title: Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.
abstract: Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000:1.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC 27710.
authors.forename: L H
authors.initials: LH
authors.lastname: Yamaoka
authors.forename: C A
authors.initials: CA
authors.lastname: Westbrook
authors.forename: M C
authors.initials: MC
authors.lastname: Speer
authors.forename: J M
authors.initials: JM
authors.lastname: Gilchrist
authors.forename: E W
authors.initials: EW
authors.lastname: Jabs
authors.forename: E G
authors.initials: EG
authors.lastname: Schweins
authors.forename: J M
authors.initials: JM
authors.lastname: Stajich
authors.forename: P C
authors.initials: PC
authors.lastname: Gaskell
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
mesh_terms: D002874:Chromosome Mapping; D004276:DNA, Satellite / Q000032:analysis*; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D009136:Muscular Dystrophies / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D004276:DNA, Satellite