Cyclosporin A monitoring in Australia: consensus recommendations.
Cyclosporin-A (CsA) therapeutic drug monitoring plays an integral role in therapeutic management of immunosuppressed patients, including those with organ transplants. This communication, prepared by an Australian team, presents recommendations for the routine monitoring of CsA, including blood sampling methodological approaches and interpretation of results generated. The consensus approach described is intended to address the diversity of attitudes to CsA monitoring demonstrated in a recent national survey of Australian laboratories that provide CsA analyses.
Morris
R G
RG
Department of Clinical Pharmacology, Queen Elizabeth Hospital, Woodville South, South Australia.
Tett
S E
SE
Ray
J E
JE
D001315:Australia; D002623:Chemistry Techniques, Analytical / Q000379:methods; D016572:Cyclosporine / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D016903:Drug Monitoring / Q000592:standards*; D017248:Enzyme Multiplied Immunoassay Technique; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D007753:Laboratories / Q000592:standards; D011786:Quality Control; D011863:Radioimmunoassay; D013048:Specimen Handling / Q000379:methods
D016572:Cyclosporine