title: Patient-controlled analgesia following caesarean section under general anaesthesia: a comparison of fentanyl with morphine.
abstract: This prospective, randomised, double-blind study compared PCA fentanyl with PCA morphine for post-Caesarean section analgesia. Following a standardised general anaesthetic, 37 women were allocated to receive either fentanyl (n = 18) or morphine (n = 19). The PCA was commenced after the women had been made comfortable in the postanaesthetic recovery room with the appropriate opioid solution (mean dose required = fentanyl 375 micrograms or morphine 16 mg). Initial PCA settings were bolus 1 ml (fentanyl 25 micrograms or morphine 1 mg), lockout time ten minutes, and no background infusion. Both analgesic solutions provided effective analgesia for a mean of 37 hr with high levels of patient satisfaction, and there were no differences in VAS scores for pain and patient satisfaction, or for side effects (nausea, itch, and sleepiness) between fentanyl or morphine. However, more patients in the fentanyl group required supplementary boluses or alterations to the PCA settings (13/18 vs 4/19: P = 0.005), and one patient was removed from the study due to inadequate analgesia. We conclude that fentanyl is not recommended for routine PCA use following Caesarean section.
authors.affiliation: Department of Anaesthesia, University of British Columbia's Women's Hospital, Vancouver, Canada.
authors.forename: P R
authors.initials: PR
authors.lastname: Howell
authors.forename: D R
authors.initials: DR
authors.lastname: Gambling
authors.forename: T
authors.initials: T
authors.lastname: Pavy
authors.forename: G
authors.initials: G
authors.lastname: McMorland
authors.forename: M J
authors.initials: MJ
authors.lastname: Douglas
mesh_terms: D000328:Adult; D016362:Analgesia, Obstetrical / Q000379:methods; D016058:Analgesia, Patient-Controlled / Q000379:methods; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D009325:Nausea / Q000139:chemically induced; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control; D017060:Patient Satisfaction; D011247:Pregnancy; D011446:Prospective Studies; D011537:Pruritus / Q000139:chemically induced; D012894:Sleep Stages / Q000187:drug effects; D014839:Vomiting / Q000139:chemically induced
chemical_list: D009020:Morphine; D005283:Fentanyl