title: Multiple and multigeneric anthelmintic resistance on a sheep farm in Malaysia.
abstract: The anthelmintic efficacy of benzimidazoles, levamisole, closantel, ivermectin and moxidectin was evaluated on an institutional farm in Malaysia using faecal egg count reduction tests, controlled slaughter trials and an in vitro egg hatch assay. The results of this study indicated simultaneous resistance of Haemonchus contortus against benzimidazoles and ivermectin and of Trichostrongylus colubriformis against benzimidazoles and levaminsole on the same farm. Moxidectin was effective against the ivermectin resistant H. contortus.
authors.affiliation: Institute of Advanced Studies, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: S
authors.initials: S
authors.lastname: Sivaraj
authors.forename: P
authors.initials: P
authors.lastname: Dorny
authors.forename: J
authors.initials: J
authors.lastname: Vercruysse
authors.forename: V S
authors.initials: VS
authors.lastname: Pandey
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001562:Benzimidazoles / Q000627:therapeutic use; D004351:Drug Resistance; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects; D007559:Ivermectin / Q000627:therapeutic use; D007978:Levamisole / Q000627:therapeutic use; D018942:Macrolides; D008296:Malaysia; D010270:Parasite Egg Count; D012458:Salicylanilides / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases; D014253:Trichostrongylosis / Q000188:drug therapy / Q000662:veterinary*; D014254:Trichostrongylus / Q000187:drug effects
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D018942:Macrolides; D012458:Salicylanilides; D007978:Levamisole; D007559:Ivermectin; C023342:closantel; C027837:moxidectin