title: Ferula communis variety brevifolia intoxication of sheep.
abstract: Sheep given powdered Ferula communis variety brevifolia at dosage of 2.5 g/kg of body weight/d for 15 days developed classical clinical signs of intoxication: anorexia, somnolence, apparent weakness, and hemorrhage. Marked reduction of vitamin K-dependent coagulation factors and prolongation of prothrombin time and activated partial thromboplastin time were consistent with presence of ferulenol, a toxic coumarinic factor in the plant. Changes induced in the coagulation system developed by the second day of plant administration and were normal within 4 days after dosing was stopped. There was no evidence of primary liver damage or platelet malfunction. Of 6 intoxicated sheep, 2 died with only minimal evidence of hemorrhage.
authors.affiliation: Department of Veterinary Pathology, Institut Agronomique et Véterinaire Hassan II, Rabat, Morocco.
authors.forename: N
authors.initials: N
authors.lastname: Tligui
authors.forename: G R
authors.initials: GR
authors.lastname: Ruth
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism; D001800:Blood Specimen Collection / Q000662:veterinary; D005309:Ferula; D006470:Hemorrhage / Q000209:etiology / Q000662:veterinary; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011041:Poisoning / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D011897:Random Allocation; D012016:Reference Values; D012756:Sheep; D012757:Sheep Diseases; D013997:Time Factors
chemical_list: D001779:Blood Coagulation Factors