CRH and the noradrenergic system mediate the antinociceptive effect of central interleukin-1 alpha in the rat.
After intracerebroventricular administration, both interleukin-1 alpha and corticotropin-releasing hormone increase nociceptive thresholds evaluated by the hot-plate test in the rat. Pretreatment with 6-hydroxydopamine or prazosin fully prevents the action of both substances. Moreover, the effect of interleukin-1 alpha is completely blocked by the intracerebroventricular administration of the corticotropin-releasing hormone antagonist alpha-helical CRH 9-41. Our results suggest an involvement of CRH and the noradrenergic system in the antinociceptive effect of central interleukin-1 alpha.
Bianchi
M
M
Department of Pharmacology, School of Medicine, University of Milano, Italy.
Panerai
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AE
D000818:Animals; D001921:Brain / Q000502:physiology*; D002395:Catecholamines / Q000037:antagonists & inhibitors; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology; D017288:Pain Threshold / Q000187:drug effects; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D011994:Recombinant Proteins
D002395:Catecholamines; D007375:Interleukin-1; D011994:Recombinant Proteins; C069206:alpha helical corticotropin-releasing hormone; D016627:Oxidopamine; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine; D011224:Prazosin