Differentiation and self-renewal in the mouse gastrointestinal epithelium.
The mouse gut epithelium represents a dynamic, geographically well organized, developmental system for examining self-renewal and differentiation. Reagents are now available for identifying the molecular mechanisms that regulate cell fate in the gut, the migration-associated differentiation programs of its component cell lineages, and its axial patterning. Considerable attention needs to be paid to two variables when studying gastrointestinal epithelial cell biology: space and time. This has necessitated the use of normal, chimeric, and transgenic animals as experimental models.
Gordon
J I
JI
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110.
Hermiston
M L
ML
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004064:Digestive System / Q000166:cytology* / Q000196:embryology; D004847:Epithelial Cells; D005544:Forecasting; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008822:Mice, Transgenic