Development of bioabsorbable glass fibres.
Calcium-iron phosphate glasses with an iron oxide content ranging from 5 wt.% to 22 wt.% were prepared to investigate the effect of iron oxide on the properties of the glass. It was found that the dissolution rate, the fibre strength and the glass transition temperature were strongly affected by iron oxide. The glass dissolution rate exhibited a 50-fold reduction while the fibre strength doubled when the iron oxide content was increased from 5 wt.% to 22 wt.%. The phosphate glass containing 22 wt.% of iron oxide had a dissolution rate of about 5 micrograms/(cm2 day). The fibres drawn from this glass also exhibited the highest tensile strength over 1000 MPa. A cortical bone plug method was used to assess the biocompatibility of the glasses with the hard and soft tissues. The tissues surrounding the samples showed no inflammation at 9 wk.
Lin
S T
ST
Zimmer Inc., Warsaw, IN.
Krebs
S L
SL
Kadiyala
S
S
Leong
K W
KW
LaCourse
W C
WC
Kumar
B
B
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D003198:Computer Simulation; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011817:Rabbits; D013718:Tensile Strength
D001672:Biocompatible Materials; D005290:Ferric Compounds; C000499:ferric oxide; C035885:ferric phosphate; D002118:Calcium