Thyroid hormones and the central nervous system.
Thyroid hormones have a significant influence on the development and maturation of the central nervous system. Among their actions, T3 and T4 have effects on the differentiation of various cell types in the rat brain and cerebellum as well as on the process of myelination. Recently, several investigators have shown effects of thyroid hormones on myelin protein gene expression. Thyroid hormones seem to have a regulatory role with regard to life span. Hyperthyroid animals appear to have a shorter life and, at advanced age, show a myelin deficit. This may be due to the damage produced by the oxidative stress generated by an excess of thyroid hormones.
Pasquini
J M
JM
Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
Adamo
A M
AM
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology / Q000502:physiology* / Q000503:physiopathology; D002454:Cell Differentiation / Q000187:drug effects; D002531:Cerebellum / Q000502:physiology; D015870:Gene Expression; D006706:Homeostasis; D006980:Hyperthyroidism / Q000503:physiopathology; D007037:Hypothyroidism / Q000503:physiopathology; D009185:Myelin Proteins / Q000096:biosynthesis; D009186:Myelin Sheath / Q000502:physiology; D018384:Oxidative Stress; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology / Q000502:physiology*; D014284:Triiodothyronine / Q000494:pharmacology / Q000502:physiology*
D009185:Myelin Proteins; D014284:Triiodothyronine; D013974:Thyroxine