title: Outcome of Toxoplasma gondii mismatches in heart transplant recipients over a period of 8 years.
abstract: Donor-related infection due to Toxoplasma gondii is a well-recorded complication of cardiac transplantation. In order to assess the efficacy of co-trimoxazole in small doses as prophylaxis for primary Toxoplasma gondii infection in seronegative heart and heart-lung transplant recipients receiving organs from seropositive donors, we reviewed the serostatus and clinical outcome of all such mismatched transplants performed at our unit over a period of 8 years. Of 310 transplants performed between May 1985 and May 1993, donor and recipient serum samples were available for 257 heart and 33 heart-lung transplants. Of these, 13 (4.5%) were toxoplasma mismatches. Post-transplant review serum samples were available for 3 months or longer for nine of the 13 mismatches. The first three patients received co-trimoxazole 480 mg bd orally for 3 months (regimen A) while the remainder received only the standard prophylaxis designed for Pneumocystis carinii i.e., 960 mg bd orally three times per week for 3 months (regimen B). Seroconversion was demonstrated in only one patient (regimen A). Furthermore, none of the mismatched patients developed serious infection compatible with primary toxoplasmosis. We therefore conclude that in centres with a low prevalence of toxoplasma seropositivity, testing of donor and recipient serum for Toxoplasma gondii antibody should be performed only when clinically indicated and, in addition, standard prophylaxis for Pneumocystis carinii may be adequate for preventing primary toxoplasmosis.
authors.affiliation: Department of Microbiology, Freeman Hospital, Newcastle upon Tyne, U.K.
authors.forename: K E
authors.initials: KE
authors.lastname: Orr
authors.forename: F K
authors.initials: FK
authors.lastname: Gould
authors.forename: G
authors.initials: G
authors.lastname: Short
authors.forename: J H
authors.initials: JH
authors.lastname: Dark
authors.forename: C J
authors.initials: CJ
authors.lastname: Hilton
authors.forename: P A
authors.initials: PA
authors.lastname: Corris
authors.forename: R
authors.initials: R
authors.lastname: Freeman
mesh_terms: D000293:Adolescent; D000328:Adult; D000913:Antibodies, Protozoan / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D014019:Tissue Donors; D014123:Toxoplasmosis / Q000276:immunology / Q000517:prevention & control*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D000913:Antibodies, Protozoan; D015662:Trimethoprim, Sulfamethoxazole Drug Combination