title: Variability of peak expiratory flow rate in children: short and long term reproducibility.
abstract: BACKGROUND
  Variability of peak expiratory flow (PEF) has been proposed as a surrogate for bronchial hyperresponsiveness. The normal range of variability of PEF for children has been reported and the test has been used to screen for asthma in population based studies. However, there is little information on the reproducibility of the method in epidemiological settings.
  
  
  METHODS
  In a cohort study of primary school children the variability in PEF was recorded in two consecutive years for one week (first survey) and two weeks (second survey) using mini Wright peak flow meters. PEF was recorded twice daily (morning and evening) and average amplitude as a percentage of mean was calculated as a standard measure of PEF variability for each single week of PEF measurement. Children with PEF variability exceeding the 90% percentile of the distribution for the specific time period were regarded as having increased variability of PEF.
  
  
  RESULTS
  Of 66 children with increased PEF variability in the first year, 13 (19.7%) had an abnormal test in the first week of the second year. Of 543 children with normal PEF variability in the first year, 44 (8.1%) had an abnormal test in the second study year (odds ratio 2.8, confidence interval (CI) 1.4 to 5.4). Of 646 children in the second survey 61 (9.4%) were abnormal during the first week and 68 (10.5%) had an increased PEF variability during the second week, but only 24 (3.7%) children had an increased PEF variability in both weeks. The sensitivity (specificity) for doctor-diagnosed asthma (12 month period prevalence) was 36.4% (91.0%) in the first week of the second survey. When measurements of both weeks of the second survey were used to calculate PEF variability there was little improvement in the sensitivity (38.1%) and specificity (91.5%), mainly because of decreased compliance in the second measurement week.
  
  
  CONCLUSIONS
  In young children assessment of PEF variability in order to screen for asthma is of limited value because of the low reproducibility of the method.
authors.affiliation: University Children's Hospital, Vienna, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Frischer
authors.forename: R
authors.initials: R
authors.lastname: Meinert
authors.forename: R
authors.initials: R
authors.lastname: Urbanek
authors.forename: J
authors.initials: J
authors.lastname: Kuehr
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D002648:Child; D015331:Cohort Studies; D006801:Humans; D016017:Odds Ratio; D010366:Peak Expiratory Flow Rate; D015995:Prevalence; D015203:Reproducibility of Results; D012130:Respiratory Hypersensitivity / Q000503:physiopathology; D012135:Respiratory Sounds / Q000503:physiopathology; D012680:Sensitivity and Specificity; D013997:Time Factors