Histamine depletion in brain caused by treatment with (S)alpha-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons.
The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.
Sugimoto
K
K
Department of Pharmacology I, Tohoku University School of Medicine, Sendai, Japan.
Abe
K
K
Lee
T H
TH
Sakurai
E
E
Yanai
K
K
Kogure
K
K
Itoyama
Y
Y
Watanabe
T
T
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002545:Brain Ischemia / Q000473:pathology*; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D006632:Histamine / Q000378:metabolism*; D006633:Histamine Antagonists / Q000494:pharmacology; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000473:pathology*
D006633:Histamine Antagonists; D008762:Methylhistidines; C028309:alpha-fluoromethylhistidine; D006632:Histamine