title: Modulatory influence of camphor on the activities of hepatic carcinogen metabolizing enzymes and the levels of hepatic and extrahepatic reduced glutathione in mice.
abstract: The present paper deals with the modulatory influence of camphor on the activities of hepatic phase I and phase II drug metabolising enzymes and the levels of hepatic and extrahepatic reduced glutathione contents in the mouse. Female Swiss albino mice (8-9 weeks old) were treated daily by oral route for 20 days with 50, 150 or 300 mg/kg body weight of camphor dissolved in 0.1 ml of olive oil. Camphor only at the 300 mg/kg body weight dose level caused a significant increase in the activities of cytochrome P450 (P < 0.05), cytochrome b5 (P < 0.05), aryl hydrocarbon hydroxylase (P < 0.05) and glutathione S-transferase (P < 0.05). These modulatory effects were comparable with those induced by 0.75% BHA diet given for 20 days (positive control group). The reduced glutathione level was elevated significantly in liver (P < 0.05) by camphor only at the 300 mg/kg body weight dose level and in liver, lung and stomach (P < 0.05) by BHA.
authors.affiliation: Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
authors.forename: C W
authors.initials: CW
authors.lastname: Welsch
authors.forename: A R
authors.initials: AR
authors.lastname: Rao
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D002164:Camphor / Q000494:pharmacology*; D002273:Carcinogens / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000378:metabolism; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism
chemical_list: D002273:Carcinogens; D002083:Butylated Hydroxyanisole; D002164:Camphor; D005978:Glutathione