title: Accumulation of natural killer cells after hepatic artery embolisation in the midgut carcinoid syndrome.
abstract: Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients.
authors.affiliation: Department of Surgery, Sahlgrenska Hospital, Gothenburg, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Wängberg
authors.forename: H
authors.initials: H
authors.lastname: Ahlman
authors.forename: U
authors.initials: U
authors.lastname: Tylén
authors.forename: O
authors.initials: O
authors.lastname: Nilsson
authors.forename: S
authors.initials: S
authors.lastname: Hermodsson
authors.forename: K
authors.initials: K
authors.lastname: Hellstrand
mesh_terms: D003602:Cytotoxicity, Immunologic; D004621:Embolization, Therapeutic; D006499:Hepatic Artery; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology* / Q000628:therapy*; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology / Q000556:secondary* / Q000628:therapy*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008303:Malignant Carcinoid Syndrome / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D010641:Phenotype