Effect of albendazole on the larvae and eggs of Necator americanus in golden hamster.
When golden hamsters infected with adult Necator americanus were treated ig with albendazole(Alb) 75 or 150 mg/kg, the efficacy rates were 83.8% and 100%, respectively. Three days before treatment, the mean numbers of larvae recorded from the incubation of feces from 2 treated groups were 29,716 +/- 3,299 and 28,256 +/- 118 per gram of feces, while in the control group, it was 8,828 +/- 2,659. Within 3 days after treatment, no larva was detected in the 2 treated groups, but in the control group the mean larva number was 9,066 +/- 7,416. Furthermore, in 2 treated groups none or only a few degenerated eggs could be found using saturated saline solution method. when infected golden hamsters were treated ig with Alb at a single dose of 150 or 300 mg/kg on day 3, 7 or 14 after infection with the third stage larvae, the egg positive rates in the feces were 0-9.1%, while the worm reduction rates were 96.8-100%.
Ren
H
H
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine (WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis), Shanghai.
Qiang
H
H
Jin
Q
Q
Zhao
L
L
Li
B
B
Zhang
C
C
Xiao
S
S
D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D006224:Cricetinae; D005260:Female; D007814:Larva / Q000187:drug effects; D008297:Male; D008647:Mesocricetus; D017221:Necator americanus / Q000187:drug effects*; D009332:Necatoriasis / Q000188:drug therapy*; D010063:Ovum / Q000187:drug effects
D015766:Albendazole