[Ways of finding inhibitors of HIV reproduction among nucleotides].
In spite of continuous broad search for inhibitors of HIV reproduction among new nucleosides, there seems to be a certain crisis in the problem. One of the probable solutions could be based on the investigation of nucleotide and/or nucleoside 5'-triphosphates with modified carbohydrate and phosphate residues. The review analyzes the current state of the problem, examining of such types of compounds in cell-free systems with DNA polymerases and in HIV-infected cell cultures. The known data on the stability and metabolism of such compounds in cell cultures as well as in human serum are also analyzed.
Kraevskiĭ
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AA
D002478:Cells, Cultured; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D015195:Drug Design; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009711:Nucleotides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects*
D009711:Nucleotides; D010710:Phosphates; D004259:DNA-Directed DNA Polymerase
Puti poiska ingibitorov reproduktsii HIV sredi nukleotidov.