Behavioral and developmental effects of two 3,4-methylenedioxymethamphetamine (MDMA) derivatives.
The effects of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstacy') and two structurally related compounds, N-methyl-1-(3,4-methylenedioxyphenyl)-1-ethanamine (MDM1EA) and N-methyl-1-(3,4-methylenedioxyphenyl)-3-butanamine (HMDMA) were examined in two preparations: (i) a drug discrimination procedure in MDMA-trained rats and (ii) the chicken embryo, for determination of the direct effects of these compounds on the developing organism. The highest doses of MDM1EA and HMDMA partially substituted for MDMA, whereas higher (30-60 mg/kg) doses of HMDMA evoked clonic seizures in a separate group of rats. In chicken embryos MDMA had no effect on body, brain or liver weight, while the highest dose of MDM1EA decreased body weight and the 2 lowest doses of HMDMA increased body weight. All doses of HMDMA decreased liver weight (expressed as % body weight) when compared with contemporaneous water-treated controls. Taken together, the results of these experiments suggest that structurally related compounds share some stimulus properties with MDMA and may therefore share abuse liability. Furthermore, both MDMA-related compounds produced adverse effects on the developing organism, whereas MDMA did not.
Bronson
M E
ME
Department of Pharmacal Sciences, Auburn University, AL 36849-5503.
Barrios-Zambrano
L
L
Jiang
W
W
Clark
C R
CR
DeRuiter
J
J
Newland
M C
MC
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D001143:Arousal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002642:Chick Embryo; D015198:Designer Drugs / Q000494:pharmacology* / Q000633:toxicity; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship
D015198:Designer Drugs; C088582:3,4-methylenedioxyphenyl-1-ethanamine; D015104:3,4-Methylenedioxyamphetamine; C042601:N-methyl-3,4-methylenedioxyphenylisobutylamine; D018817:N-Methyl-3,4-methylenedioxyamphetamine