title: Prediction of serum markers of fibrosis by levels of circulating intercellular adhesion molecule-1 in acute and chronic liver disease.
abstract: To clarify the link between cytotoxic damage to the hepatocyte and the development of fibrosis, we immunoenzymatically measured serum prolyl hydroxylase (hPH), type IV collagen (CL-IV) and circulating intercellular adhesion molecule-1 (clCAM-1). The population studied was comprised of 122 patients with liver disease (acute hepatitis; mild chronic liver disease; cirrhosis; hepatocellular carcinoma) and 33 patients with extrahepatic diseases. Similar patterns were observed for hPH, CL-IV, and clCAM-1, that were higher in patients with acute hepatitis and hepatocellular carcinoma than in those with mild chronic liver disease (Bonferroni's test for pairwise comparisons, p < 0.01). Liver function tests and markers of fibrosis showed a strict correlation, which disappeared when the linear effect of clCAM-1 was removed. The ability to predict serum hPH and CL-IV from clCAM-1 might suggest the existence of a causal relationship between fibrosis and targeting of cytotoxic damage.
authors.affiliation: Cattedra di Medicina Interna, Medical School, University of Udine, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Fabris
authors.forename: M
authors.initials: M
authors.lastname: Pirisi
authors.forename: E
authors.initials: E
authors.lastname: Falleti
authors.forename: G
authors.initials: G
authors.lastname: Soardo
authors.forename: F
authors.initials: F
authors.lastname: Gonano
authors.forename: E
authors.initials: E
authors.lastname: Bartoli
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002908:Chronic Disease; D003094:Collagen / Q000097:blood; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008103:Liver Cirrhosis / Q000175:diagnosis; D008107:Liver Diseases / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011393:Procollagen-Proline Dioxygenase / Q000097:blood
chemical_list: D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase