Effects of captopril and nadolol on renal hemodynamics in patients with essential hypertension.
The randomized single-blind study was designed to compare the effects of captopril (Cap) and nadolol (Nad) on renal hemodynamics in 60 patients with essential hypertension. They were divided into two groups at random. Cap was given in dosage of 37.5-75 mg/d per os and Nad 40-80 mg/d. The results show that both drugs increase the blood volume distributed to the kidneys from cardiac output (renal blood flow/cardiac output), Cap increasing 10% (P < 0.05) and Nad 8% (P < 0.05). Renal vascular resistance (RVR) is lowered by the two drugs, 13% (P < 0.05) by Cap and 11% (P < 0.05) by Nad. These suggest that both drugs facilitate the maintenance of renal blood circulation in patients with essential hypertension, being beneficial for long-term treatment of hypertension.
Zhu
Z H
ZH
Department of Nephrology, Xiehe Hospital, Tongji Medical University, Wuhan.
An
R
R
Zhang
Y X
YX
Gong
P L
PL
Chen
H
H
Zen
F D
FD
D000328:Adult; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009248:Nadolol / Q000494:pharmacology* / Q000627:therapeutic use; D012079:Renal Circulation / Q000187:drug effects*; D016037:Single-Blind Method
D009248:Nadolol; D002216:Captopril