An equation for the dose response of radiation-induced apoptosis: possible incorporation with the LQ model.
Based on in vitro and in vivo data, we proposed an equation to describe the dose response of radiation-induced apoptosis. This equation can be incorporated into the LQ model to account for the contribution of apoptosis-mediated cell death in clonogenic survival curve. The modified LQ equation is a composite of the dose responses of two subpopulations, one susceptible and the other resistant to apoptotic cell death. For the apoptosis-resistant fraction, the size of which varies for different biological systems, the conventional LQ relation applies. For the susceptible subpopulation, the LQ equation is modified by e-zeta D, a functional form consistent with the observed dose-rate independence of this mode of cell death.
Ling
C C
CC
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
Chen
C H
CH
Fuks
Z
Z
D000465:Algorithms; D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D016923:Cell Death / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D015233:Models, Statistical; D011829:Radiation Dosage; D011879:Radiotherapy Dosage