title: Monoclonal antibody to the C-terminus of beta-amyloid.
abstract: Soluble amyloid beta-protein (A beta) is normally produced, but forms deposits in the brain of Alzheimer's (AD) patients. The length of isolated A beta in SDS-insoluble amyloid from AD brain is reported to vary between plaques and vessels ranging from 28 to 43, with major species being 40 and 42 residues. Because the A beta C-terminus determines aggregation rates, we made an A beta monoclonal antibody distinguishing beta 1-42 from beta 1-40. In AD cortex, the beta 1-42 antibody recognizes all the structures identified by monoclonal to beta 1-40 on adjacent sections: plaque cores, diffuse A beta deposits and vascular amyloid. These antibodies help define variation in A beta length between different deposits, regions and autopsied brains.
authors.affiliation: Department of Medicine, UCLA.
authors.forename: F
authors.initials: F
authors.lastname: Yang
authors.forename: K
authors.initials: K
authors.lastname: Mak
authors.forename: H V
authors.initials: HV
authors.lastname: Vinters
authors.forename: S A
authors.initials: SA
authors.lastname: Frautschy
authors.forename: G M
authors.initials: GM
authors.lastname: Cole
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D012995:Solubility
chemical_list: D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal