title: Hydroxyl radicals and DNA double-strand breaks in X-irradiated E. coli.
abstract: We have used glycerol to study the relationship between hydroxyl radicals, one of the primary radiolytic products, and the production of DNA double-strand breaks in selected E. coli strains. Our results suggest that when bacteria are irradiated at doses up to about 120 Gray, hydroxyl radicals produce DNA lesions, but not double-strand breaks.
authors.affiliation: Department of Radiation Oncology & Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102.
authors.forename: D
authors.initials: D
authors.lastname: Ewing
authors.forename: K E
authors.initials: KE
authors.lastname: Damsker
mesh_terms: D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects / Q000528:radiation effects*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D005990:Glycerol / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D004269:DNA, Bacterial; D017665:Hydroxyl Radical; D005990:Glycerol