ACTH, cortisol and glucose responses after administration of vasopressin in cattle and sheep.
The present study compared the effects of vasopressin on plasma concentrations of corticotropin, cortisol and glucose in cattle and sheep. After intravenous injection of 1, 0.1 and 0.01 microgram vasopressin per kg body weight, the plasma vasopressin concentration increased proportionally to the injected dose, and this increase was similar in cattle and sheep. Doses of 1 and 0.1 microgram per kg body weight of vasopressin triggered significant responses of corticotropin, cortisol and glucose in cattle and sheep. The corticotropin response to both doses was significantly greater in sheep, whereas the glucose response was greater in cattle. The cortisol response did not differ between species. The lowest dose of vasopressin (0.01 microgram per kg body weight) still induced a significant cortisol response without a substantial effect on plasma corticotropin, suggesting that a direct action of vasopressin on the adrenals may contribute to the observed cortisol response. The results demonstrate that vasopressin increases plasma levels of corticotropin, cortisol and glucose in cattle, as it does in sheep, but the intensities of the corticotropin and glucose responses to vasopressin differ between cattle and sheep. The reasons for these differences remain to be clarified.
Senn
M
M
Institute for Animal Sciences, Swiss Federal Institute of Technology, Zurich.
Maier
P M
PM
Langhans
W
W
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D002417:Cattle / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D009994:Osmolar Concentration; D012756:Sheep / Q000097:blood
D001786:Blood Glucose; D001127:Arginine Vasopressin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone