Carcinoembryonic antigen-transgenic mice: a model for tumor immunotherapy.
The tumor marker carcinoembryonic antigen (CEA) is a 180-kD glycoprotein expressed on epithelial cells of the gastrointestinal tract and respiratory organs. It is a member of a large family belonging to the immunoglobulin superfamily. In order to develop a mouse model to study tumor immunotherapy using CEA as a target antigen, we have established mice which are transgenic for the CEA gene. The human CEA transgene maintains its spatiotemporal expression pattern in transgenic mice thus providing a suitable model in which to optimize different immunotherapy approaches, with the advantage that negative side effects due to the presence of CEA in normal tissue can be analyzed.
Eades-Perner
A M
AM
Institute of Immunobiology, University of Freiburg, Germany.
Zimmermann
W
W
D000818:Animals; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D004195:Disease Models, Animal; D015870:Gene Expression; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental / Q000628:therapy*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen