Reaction of malondialdehyde with deoxyribonucleosides in the presence of acetaldehyde.
The reactivity of malondialdehyde (MDA) with deoxyribonucleosides in the presence of acetaldehyde (AA) was investigated. Although MDA is known to be reactive towards deoxyguanosine (GdR), deoxyadenosine (AdR) and deoxycytidine (CdR) under acidic conditions, MDA had only slight reactivity towards GdR under physiological pH. However, when AA was present, MDA exhibited much higher reactivity towards GdR, and a reaction with AdR also took place.
Ohya
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Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
D000079:Acetaldehyde / Q000737:chemistry*; D000241:Adenosine / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003841:Deoxycytidine / Q000378:metabolism; D003849:Deoxyguanosine / Q000378:metabolism; D003853:Deoxyribonucleosides / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008315:Malondialdehyde / Q000737:chemistry / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
D003853:Deoxyribonucleosides; D003841:Deoxycytidine; D008315:Malondialdehyde; D003849:Deoxyguanosine; D000079:Acetaldehyde; D000241:Adenosine