title: Effect of multiple doses of volatile anesthetics on heme enzymes.
abstract: 1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose levels was studied. 2. Liver and kidney delta-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in animals receiving one dose of Isoflurane. 3. Blood Porphobilinogenase and deaminase (50%, P < 0.01) inhibition was produced only when animals received a single dose of the anesthetics. 5. ALA-S induction observed after the third dose of anesthetics could be a consequence of long lasting depletion in heme synthesis produced by blocking at uroporphyrinogen level.
authors.affiliation: Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP)-(CONICET-FCEN, UBA), Ciudad Universitaria, Buenos Aires, Argentine.
authors.forename: A M
authors.initials: AM
authors.lastname: Buzaleh
authors.forename: R
authors.initials: R
authors.lastname: Enriquez de Salamanca
authors.forename: A M
authors.initials: AM
authors.lastname: Batlle
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000642:Ammonia-Lyases / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004737:Enflurane / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006418:Heme / Q000378:metabolism*; D007530:Isoflurane / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D006418:Heme; D004737:Enflurane; D007530:Isoflurane; D000624:5-Aminolevulinate Synthetase; D000642:Ammonia-Lyases; C100132:porphobilinogenase; D005947:Glucose