title: Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine.
abstract: The mouse uromodulin cDNA sequence was sequenced. The predicted peptide sequence is 642 amino acids long and contains several modular components including four epidermal growth factor like repeats, one betaglycan-like domain (ZP domain), and a consensus sequence for attachment of a glycosyl-phosphatidyl-inositol anchor. An arginine-glycine-aspartate tripeptide reported for rat and human sequence is absent in the mouse. There are several potential sites for post-translational modification.
authors.affiliation: Warren Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City 73104.
authors.forename: K
authors.initials: K
authors.lastname: Prasadan
authors.forename: J
authors.initials: J
authors.lastname: Bates
authors.forename: A
authors.initials: A
authors.lastname: Badgett
authors.forename: M
authors.initials: M
authors.lastname: Dell
authors.forename: V
authors.initials: V
authors.lastname: Sukhatme
authors.forename: H
authors.initials: H
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009088:Mucoproteins / Q000737:chemistry / Q000235:genetics* / Q000652:urine; D051381:Rats; D017386:Sequence Homology, Amino Acid; D058949:Uromodulin
chemical_list: D018076:DNA, Complementary; D009088:Mucoproteins; C548612:UMOD protein, human; C548613:Umod protein, mouse; C548614:Umod protein, rat; D058949:Uromodulin