title: Sulfation of parabens and tyrosylpeptides by bacterial arylsulfate sulfotransferases.
abstract: Arylsulfate sulfotransferase purified from Eubacterium A-44 has higher specific activity than the enzymes from Klebsiella K-36 and Haemophilus K-12. Propylparaben and butylparaben were good substrates among several parabens. The antibacterial activity of parabens was reduced by the sulfation of the phenolic hydroxy group. Tyrosine-containing peptides, kyotorphin, enkephalin and cholecystokinin non-sulfate, were effective as acceptor substrates by A-44, K-36 and K-12 sulfotransferases.
authors.affiliation: College of Pharmacy, Kyung-Hee University, Seoul, Korea.
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: B
authors.initials: B
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: I S
authors.initials: IS
authors.lastname: Sohng
authors.forename: K
authors.initials: K
authors.lastname: Kobashi
mesh_terms: D000818:Animals; D015239:Arylsulfotransferase / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D002766:Cholecystokinin / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000378:metabolism; D005051:Eubacterium / Q000201:enzymology*; D005243:Feces / Q000201:enzymology / Q000382:microbiology; D005658:Fungi / Q000187:drug effects; D006190:Haemophilus / Q000201:enzymology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D062385:Hydroxybenzoates / Q000378:metabolism; D007422:Intestines / Q000201:enzymology / Q000382:microbiology; D007709:Klebsiella / Q000201:enzymology; D008297:Male; D051379:Mice; D009284:Naphthols / Q000378:metabolism; D010226:Parabens / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D010636:Phenols / Q000378:metabolism; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects; D013379:Substrate Specificity
chemical_list: D004723:Endorphins; D062385:Hydroxybenzoates; D009284:Naphthols; D010226:Parabens; D010636:Phenols; C019448:kyotorphin; C029350:1-naphthol; C038091:butylparaben; D004743:Enkephalin, Leucine; D002766:Cholecystokinin; D015239:Arylsulfotransferase; C090707:arylsulfate sulfotransferase; C006068:propylparaben