m-Chlorophenylpiperazine decreases food intake in a test meal.
We studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused significant increases in ratings of nausea and light-headedness, though these effects had remitted by the time of the test meal. The results suggest that activation of brain 5-HT2C receptors may lower food intake in humans; it is also possible, however, that the hypophagic effect of mCPP in the present study could be a consequence of its adverse subjective side effects.
Walsh
A E
AE
Psychopharmacology Research Unit, Littlemore Hospital, Oxford, UK.
Smith
K A
KA
Oldman
A D
AD
Williams
C
C
Goodall
E M
EM
Cowen
P J
PJ
D000328:Adult; D003864:Depression, Chemical; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D005260:Female; D006801:Humans; D006815:Hunger / Q000187:drug effects; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000494:pharmacology*
D010879:Piperazines; D017366:Serotonin Receptor Agonists; C015068:1-(3-chlorophenyl)piperazine