title: Endogenous cholecystokinin is not a major regulator of food intake in the chicken.
abstract: This study investigated whether or not endogenous cholecystokinin exerts satiety effects in chickens. After several doses (0, 1, 2 and 4 micrograms.kg body weight-1) of intravenous injection of caerulein, the bile flow was increased in a dose-dependent fashion. However, the pharmacological level of caerulein failed to suppress the food intake of chickens. Two potent stimulators of endogenous cholecystokinin, i.e., soybean trypsin inhibitor and phenylalanine were administered to chickens before feeding and food intake was determined over 2 h. The soybean trypsin inhibitor and phenylalanine did not alter food intake. Devazepide, a cholecystokinin-A receptor antagonist, significantly decreased amylase release from the dispersed chicken pancreatic acini stimulated by caerulein. However, devazepide did not improve food intake of the chicken. The results obtained suggest that endogenous cholecystokinin may not act as a satiety signal in chickens.
authors.affiliation: Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
authors.forename: Y H
authors.initials: YH
authors.lastname: Choi
authors.forename: M
authors.initials: M
authors.lastname: Furuse
authors.forename: S
authors.initials: S
authors.lastname: Satoh
authors.forename: J
authors.initials: J
authors.lastname: Okumura
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002108:Ceruletide / Q000494:pharmacology; D002645:Chickens / Q000502:physiology*; D002766:Cholecystokinin / Q000819:agonists / Q000097:blood / Q000502:physiology*; D020109:Devazepide; D004435:Eating / Q000502:physiology*; D008297:Male; D010649:Phenylalanine / Q000494:pharmacology; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000145:classification; D013025:Glycine max; D014361:Trypsin Inhibitors / Q000494:pharmacology
chemical_list: D001570:Benzodiazepinones; D011949:Receptors, Cholecystokinin; D014361:Trypsin Inhibitors; D010649:Phenylalanine; D002108:Ceruletide; D002766:Cholecystokinin; D020109:Devazepide