[Antihypertensive action of Parkia biglobosa+ (Jacq) Benth seeds in the rat].
Hundred white Wistar rats have been used to evaluate the antihypertensive effects of entire seeds and decorticated, fermented seeds of a soudanian plant, Parkia biglobosa. The arterial blood pressure was measured by using bloody method in anesthizied animals. The Pham Huu Chanh method was used to determine type plant's antihypertensive activity. According to the results obtained, in both preparations, adequate doses decrease arterial blood pressure, diastolic more than systolic, but the effect of fermented seeds was more important than the entire seeds. In the two cases, the decrease in blood pressure is greated in hypertensive than in normotensive subjects, and the hypotension induced was well correlated with a bradycardia.
Assane
M
M
Département de Physiologie, Pharmacodynamie et Thérapeutique de l'E.I.S.MV, Sénégal.
Baba Moussa
R
R
Bassene
E
E
Sere
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D012675:Senegal
D010936:Plant Extracts
Etude de l'action antihypertensive des graines de Parkia biglobosa (Jacq). Benth chez le rat.