Vasopressin inhibits food intake in pygmy goats by activation of alpha 1-adrenergic receptors.
The hypophagic effect of intraperitoneally injected VP (1.5 micrograms/kg) was blocked by concomitant injection of the alpha 1-adrenergic antagonist prazosin (27 and 40 micrograms/kg). Both the alpha 2-adrenergic antagonists idazoxan (300 micrograms/kg) and yohimbine (500 micrograms/kg) and the beta-adrenergic antagonist propranolol (500 micrograms/kg) failed to block the hypophagia induced by VP (1.5 micrograms/kg). The results suggest that the hypophagic effect of VP is mediated by alpha 1-adrenergic receptors.
Rossi
R
R
Institut für Veterinär-Physiologie, Zürich, Switzerland.
Scharrer
E
E
D058646:Adrenergic alpha-1 Receptor Agonists; D058668:Adrenergic alpha-1 Receptor Antagonists; D000818:Animals; D003864:Depression, Chemical; D004146:Dioxanes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005260:Female; D006041:Goats; D019329:Idazoxan; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology
D058646:Adrenergic alpha-1 Receptor Agonists; D058668:Adrenergic alpha-1 Receptor Antagonists; D004146:Dioxanes; D014667:Vasopressins; D015016:Yohimbine; D011433:Propranolol; D011224:Prazosin; D019329:Idazoxan