title: Pigmented villonodular synovitis. Monoclonality and metastasis--a case for neoplastic origin?
abstract: We report a 48-year follow-up of a case of recurrent pigmented villonodular synovitis of the knee. Subcutaneous metastasis to the contralateral thigh was an unusual finding. Histology demonstrated fibroblastic and histiocytic proliferation, as well as increased mitotic activity in recurrent lesions. Cytogenetic analyses demonstrated monoclonality and chromosomal abnormalities. Our findings support a neoplastic origin of this lesion.
authors.affiliation: Department of Orthopedics, Lund University Hospital, Sweden.
authors.forename: P F
authors.initials: PF
authors.lastname: Choong
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: M
authors.initials: M
authors.lastname: Nilbert
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: B
authors.initials: B
authors.lastname: Carlén
authors.forename: A
authors.initials: A
authors.lastname: Rydholm
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D011110:Polymorphism, Genetic; D012008:Recurrence; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000628:therapy; D013586:Synovitis, Pigmented Villonodular / Q000235:genetics / Q000473:pathology*; D014960:X Chromosome