Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67).
Rat p67 is an initiation factor-2 associated protein, which plays important roles in translational regulation. A cDNA that encodes a homologue of rat p67 was isolated from a human liver cDNA library. The encoded protein contains 478 amino acids with a calculated molecular mass of 52,891 and an isoelectric point of 5.64. The amino acid sequence is 92% identical to that of rat p67. The corresponding mRNA has a size of approximately 2.1 kb and is present in all tested human tissues.
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Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, MO 63104.
Chang
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D000595:Amino Acid Sequence; D000626:Aminopeptidases; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006023:Glycoproteins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D063208:Methionyl Aminopeptidases; D008969:Molecular Sequence Data; D051381:Rats; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D006023:Glycoproteins; D000626:Aminopeptidases; C081311:METAP2 protein, human; C489895:Metap2 protein, rat; D063208:Methionyl Aminopeptidases