[Effect of trans-anethole on liver monooxygenase system and its induction of polychlorinated diphenyls].
Effect of trans-anetol (t-An) as nutritive addition to cytochrome P-450 containing system (MOS) of liver of rats was studied. It was shown, that t-An rendered inducing action to MOS, which depended on degree of action. It was established that simultaneous effect of t-An and mixture of polychlorinated diphenyles (sovol) modified inducing action of sovol to cytochrome P-450 system, Simultaneous effect of t-An and mixture of polychlorinated diphenyles increased hepatotoxic action of these xenobiotics.
Sinitskaia
Z F
ZF
Lashneva
N V
NV
Chichilanova
G V
GV
Gadzhieva
Z M
ZM
Shatrov
G N
GN
Tutelían
V A
VA
D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects* / Q000378:metabolism; D005421:Flavoring Agents / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011078:Polychlorinated Biphenyls / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D005421:Flavoring Agents; C053040:Sovol; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; C006578:anethole
Vliianie trans-anetola na monooksigenaznuiu sistemy pecheni i eë induktsiiu polikhlorirovannymi difenilami.