Cdc2 regulatory factors.
A growing family of kinases and phosphatases controls the activity of the cyclin-dependent kinase cdc2. The past year has seen the identification of the cdk activating kinase as well as considerable elucidation of the cdc25/wee1 regulatory pathways. Both cdc25 and wee1 appear to be regulated by upstream kinase/phosphatase networks. In addition, it is likely that other regulatory mechanisms cooperate with the wee1/cdc25 phosphorylation systems to control the action of cdc2. Together, these elaborate checks and balances ensure that cdc2 triggers mitosis at the appropriate time.
Coleman
T R
TR
Division of Biology, California Institute of Technology, Pasadena 91125.
Dunphy
W G
WG
D000818:Animals; D016203:CDC2 Protein Kinase / Q000502:physiology*; D018797:Cell Cycle Proteins; D004789:Enzyme Activation; D006801:Humans; D016200:Maturation-Promoting Factor / Q000502:physiology; D009687:Nuclear Proteins; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011506:Proteins / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins; D020687:cdc25 Phosphatases
D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D011506:Proteins; D029702:Schizosaccharomyces pombe Proteins; C068689:wee1 protein, S pombe; D011505:Protein-Tyrosine Kinases; C499349:WEE1 protein, human; D016203:CDC2 Protein Kinase; D016200:Maturation-Promoting Factor; D010749:Phosphoprotein Phosphatases; D020687:cdc25 Phosphatases