Dietary cholesterol supplementation in the spontaneously diabetic rat.
Dietary cholesterol supplementation was used to increase serum cholesterol concentration in diabetic and non-diabetic rats. With the use of numerous dietary formulations, extremely elevated serum cholesterol concentrations and gastrointestinal intolerance were found. We conclude that there are unacceptable side effects with a vast number of exogenous cholesterol supplemented diets which preclude standard and long-term usage.
Veiga
P A
PA
Department of Pediatrics, Children's Hospital of Buffalo, New York 14222.
Van Liew
J B
JB
Zamlauski-Tucker
M J
MJ
Feld
L G
LG
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000633:toxicity; D003920:Diabetes Mellitus / Q000097:blood*; D003967:Diarrhea / Q000209:etiology; D005260:Female; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley
D002791:Cholesterol, Dietary; D002784:Cholesterol