title: In vivo evaluation of the Hydrolyser hydrodynamic thrombectomy catheter.
abstract: OBJECTIVE
  The authors evaluated a 7-F double-lumen thrombectomy catheter (Hydrolyser) in vivo.
  
  
  METHODS
  To evaluate efficacy, thrombectomy was performed 1, 4, or 8 days after local denudation in peripheral arteries (n = 18) and veins (n = 29) of nine goats. To evaluate safety, the reaction of the vessel wall to a functioning and nonfunctioning Hydrolyser catheter was evaluated in the peripheral arteries and veins of three goats 10 days after the procedure.
  
  
  RESULTS
  Reopening was achieved in all vessels with residual thrombus in 11% of arteries (two of 18) and 55% of veins (16 of 29). Slight intimal thickening was observed, but no difference was seen between the passage of a functioning versus nonfunctioning catheter.
  
  
  CONCLUSIONS
  The Hydrolyser device can remove intravascular thrombus up to 8 days after induction. There was no difference in vessel wall reaction after the passage of a functioning and nonfunctioning catheter.
authors.affiliation: Department of Cardiology, Academic Hospital Maastricht, University of Limburg, The Netherlands.
authors.forename: V
authors.initials: V
authors.lastname: van Ommen
authors.forename: F H
authors.initials: FH
authors.lastname: van der Veen
authors.forename: M J
authors.initials: MJ
authors.lastname: Daemen
authors.forename: J
authors.initials: J
authors.lastname: Habets
authors.forename: H J
authors.initials: HJ
authors.lastname: Wellens
mesh_terms: D000818:Animals; D002406:Catheterization, Peripheral / Q000009:adverse effects / Q000295:instrumentation*; D005069:Evaluation Studies as Topic; D005263:Femoral Artery; D005268:Femoral Vein; D006041:Goats; D013927:Thrombosis / Q000628:therapy*