CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats.
Modulation of learning and memory is one of the physiological roles that the neuropeptide cholecystokinin (CCK-8) may play. We have used a behavioural model of olfactory recognition among rats to test this hypothesis and to explore the relationship between CCK-A and CCK-B receptors and memory retention. Adult male rats form a transient memory of a juvenile congenere as indicated by a reduction in the duration of investigatory behaviour upon re-exposure 30 min after an initial exposure, but not when re-exposure is delayed until 120 min afterwards. In the present study, rats were treated after the first contact with various compounds; inhibition and facilitation of olfactory recognition were evaluated as the persistence in investigation 30 min and the decrease in investigation 120 min after pharmacological manipulations, respectively. Systemic injection of CCK-8, of a selective CCK-A agonist, or of non-peptide CCK-B antagonists (CI-988 and LY-262691) enhanced olfactory recognition. In contrast, the CCK-B selective agonist BC 264 and the tetrapeptide CCK-4 both disrupted it. Taken together with previous evidence of the detrimental effect of the nonpeptide. CCK-A antagonist devazepide on olfactory recognition, these results confirm and extend the hypothesis that there is a balance between CCK-A-mediated facilitative effects and CCK-B-mediated inhibitory effects on memory retention.
Lemaire
M
M
Rhône-Poulenc Rorer S.A., Centre de Recherches de Vitry-Alfortville, Département de Biologie, Vitry-sur-Seine, France.
Böhme
G A
GA
Piot
O
O
Roques
B P
BP
Blanchard
J C
JC
D000595:Amino Acid Sequence; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002766:Cholecystokinin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003071:Cognition / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology; D010671:Phenylurea Compounds; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000819:agonists* / Q000037:antagonists & inhibitors*; D012844:Sincalide / Q000494:pharmacology; D012903:Smell / Q000187:drug effects*; D012919:Social Behavior
C084553:BC 264; D001570:Benzodiazepinones; D007211:Indoles; D010446:Peptide Fragments; D010671:Phenylurea Compounds; D011720:Pyrazoles; D011949:Receptors, Cholecystokinin; C065599:PD 134308; C074681:1-(4-bromophenylaminocarbonyl)-4,5-diphenyl-3-pyrazolidinone; C058121:L 365260; D008536:Meglumine; D002766:Cholecystokinin; D012844:Sincalide