[Vasoactive neuropeptides CGRP (calcitonin gene-related peptide) and vasospasm during subarachnoid hemorrhage from ruptured intracranial aneurysm].
The authors discuss the role of active neuropeptides Calcitonin Gene-Related Peptide (CGRP) and Vasoactive Intestinal Polypeptide (VIP) in the arterial spasm caused by haemorrhage from ruptured intracranial aneurysm. These substances act as vasodilators on brain vessels. Between the first and the second week after subarachnoid haemorrhage their concentration in the periarterial nerve fibres of the big vessels is significantly low. According to the experiments, the erythrocytes are this component of the blood which causes the decrease of the number of nerve fibres containing CGRP and VIP. The clinical tests of CGRP and VIP in the treatment of the vascular spasm after subarachnoid haemorrhage are being continued.
Mosiewicz
A
A
Katedry i Kliniki Neurochirurgii Akademii Medycznej, Lublinie.
Czochra
M
M
Zderkiewicz
E
E
Markiewicz
P
P
D000784:Aortic Dissection / Q000150:complications* / Q000503:physiopathology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000209:etiology*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology* / Q000627:therapeutic use*
D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide
Naczynioaktywne neuropeptydy CGRP (calcitonin gene-related peptide) i VIP (vasoactive intestinal polypeptide) a skurcz naczyniowy w przebiegu krwawienia podpajeczynówkowego z peknietego tetniaka wewnatrzczaszkowego.