title: Reversal of post-reperfusion coagulopathy by protamine sulphate in orthotopic liver transplantation.
abstract: We report details of two liver transplant procedures in which post-reperfusion coagulopathy was reversed by administration of protamine sulphate. Both procedures were uncomplicated until about 30 min after reperfusion of the graft, when the cut surfaces began to ooze blood. Failure of coagulation was confirmed by thrombelastography and in both cases routine coagulation tests revealed a prolonged kaolin cephalin clotting time (KCT). A heparin-like effect was suspected. Protamine sulphate 50 mg was given i.v., resulting in cessation of bleeding and normalization of the thrombelastogram and KCT.
authors.affiliation: Department of Anaesthesia, Freeman Hospital, High Heaton, Newcastle upon Tyne.
authors.forename: P J
authors.initials: PJ
authors.lastname: Bayly
authors.forename: M
authors.initials: M
authors.lastname: Thick
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D016063:Blood Loss, Surgical; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D010314:Partial Thromboplastin Time; D011479:Protamines / Q000627:therapeutic use*; D015424:Reperfusion / Q000009:adverse effects*; D013916:Thrombelastography
chemical_list: D011479:Protamines