Treatment of cryptococcal meningitis with combination itraconazole and flucytosine.
The results of an open study of the efficacy of itraconazole and flucytosine in 10 patients with cryptococcal meningitis are reported. The outcome revealed eight responding cases (cure in 4 cases and improvement in 4 cases), and two failure cases. One patient had a relapse which responded to amphotericin B and flucytosine. No toxicity was observed.
Chotmongkol
V
V
Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand.
Jitpimolmard
S
S
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D016896:Treatment Outcome
D017964:Itraconazole; D005437:Flucytosine