title: Bacterial protein toxins acting on the cell cytoskeleton.
abstract: A number of bacterial protein toxins are known to exert their cytotoxic activity via a modification of cytoskeletal components. Some toxins induce the ADP-ribosylation of actin whereas others interact with the cytoskeleton by an unknown mechanism. Understanding the mode of action of such toxins at cellular level could provide useful information on their role in vivo as virulence factors.
authors.affiliation: Department of Ultrastructures, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Donelli
authors.forename: C
authors.initials: C
authors.lastname: Fiorentini
mesh_terms: D008841:Actin Cytoskeleton / Q000187:drug effects; D001427:Bacterial Toxins / Q000145:classification / Q000494:pharmacology*; D003599:Cytoskeleton / Q000187:drug effects*; D007382:Intermediate Filaments / Q000187:drug effects; D008870:Microtubules / Q000187:drug effects
chemical_list: D001427:Bacterial Toxins