Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.
The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.
Grossman
W J
WJ
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Kimata
J T
JT
Wong
F H
FH
Zutter
M
M
Ley
T J
TJ
Ratner
L
L
D000818:Animals; D001483:Base Sequence; D002451:Cell Compartmentation; D015342:DNA Probes; D016355:Genes, pX; D053804:Granzymes; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D007942:Leukemia, Experimental / Q000235:genetics* / Q000821:virology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012697:Serine Endopeptidases / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism
D015342:DNA Probes; C509213:GZMB protein, human; D053804:Granzymes; C509214:Gzmb protein, mouse; D012697:Serine Endopeptidases