Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine.
The mouse uromodulin cDNA sequence was sequenced. The predicted peptide sequence is 642 amino acids long and contains several modular components including four epidermal growth factor like repeats, one betaglycan-like domain (ZP domain), and a consensus sequence for attachment of a glycosyl-phosphatidyl-inositol anchor. An arginine-glycine-aspartate tripeptide reported for rat and human sequence is absent in the mouse. There are several potential sites for post-translational modification.
Prasadan
K
K
Warren Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City 73104.
Bates
J
J
Badgett
A
A
Dell
M
M
Sukhatme
V
V
Yu
H
H
Kumar
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009088:Mucoproteins / Q000737:chemistry / Q000235:genetics* / Q000652:urine; D051381:Rats; D017386:Sequence Homology, Amino Acid; D058949:Uromodulin
D018076:DNA, Complementary; D009088:Mucoproteins; C548612:UMOD protein, human; C548613:Umod protein, mouse; C548614:Umod protein, rat; D058949:Uromodulin