title: Caffeine clearance in the horse.
abstract: The pharmacokinetic properties of intravenously administered caffeine were studied in 10 horses using a commercially available automated enzyme immunoassay. The harmonic mean for the distribution half-life was 5.2 min (range 1.4-18.7). The harmonic mean for the elimination half-life was 10.18 h (range 6.82-20.92). The harmonic mean of the volume of distribution was 0.32 L/kg (range 0.22-0.53). There was no correlation between the dose of caffeine/kg body weight and the elimination half-life (Spearman's coefficient of rank correlation = 0.19).
authors.affiliation: Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849-5522.
authors.forename: J
authors.initials: J
authors.lastname: Schumacher
authors.forename: J S
authors.initials: JS
authors.lastname: Spano
authors.forename: R C
authors.initials: RC
authors.lastname: Wilson
authors.forename: F J
authors.initials: FJ
authors.lastname: DeGraves
authors.forename: S H
authors.initials: SH
authors.lastname: Duran
authors.forename: D C
authors.initials: DC
authors.lastname: Ruffin
mesh_terms: D000818:Animals; D002110:Caffeine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006736:Horses / Q000378:metabolism*; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male
chemical_list: D002110:Caffeine