[Results of color-coded duplex ultrasound diagnosis (angiodynography) after intraurethral administration of PgE1 in erectile dysfunction].
When the pathomechanism of erectile dysfunction is obscure, intraurethral administration of prostaglandin E1 is followed by a marked increase in blood flow velocity in the penile arteries as measured by color-coded Duplex sonography. This increase compares to that following intracavernous administration of half the dose of prostaglandin E1. The difference in the effects after intraurethral and intracavernous administration is the missing rigidity after intraurethral application; there must be a loss of pharmacological efficacy to the smooth penile muscles. Clinical efficacy is to be expected with higher intraurethral dosage.
Wechsel
H W
HW
Urologische Abteilung, Eberhard-Karls-Universität, Tübingen.
Strohmaier
W L
WL
Bichler
K H
KH
D000328:Adult; D000527:Alprostadil / Q000627:therapeutic use; D001783:Blood Flow Velocity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D018783:Impotence, Vasculogenic / Q000000981:diagnostic imaging* / Q000188:drug therapy; D007267:Injections; D008297:Male; D008875:Middle Aged; D010413:Penis / Q000098:blood supply; D018615:Ultrasonography, Doppler, Color / Q000187:drug effects*; D014521:Urethra / Q000187:drug effects
D000527:Alprostadil
Ergebnisse der Color-coded-duplex-Sonographie (Angiodynographie) nach intraurethraler Applikation von Pg E1 bei ED.