Regulation and function of the MAP kinase cascade in Xenopus oocytes.
In Xenopus oocytes, activation of MAP kinase occurs during meiotic maturation through a protein kinase cascade (the MAP kinase cascade), which is utilized commonly in various intracellular signaling pathways in eukaryotes. Studies with a neutralizing antibody against Xenopus MAP kinase kinase (MAPKK), a direct upstream activator for MAP kinase, have shown that the MAP kinase cascade plays a crucial role in both initiating oocyte maturation and inducing metaphase arrest.
Kosako
H
H
Department of Genetics and Molecular Biology, Kyoto University, Japan.
Gotoh
Y
Y
Nishida
E
E
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D004789:Enzyme Activation; D008677:Metaphase / Q000502:physiology; D009865:Oocytes / Q000201:enzymology / Q000254:growth & development; D015398:Signal Transduction / Q000502:physiology*; D014981:Xenopus
D017871:Calcium-Calmodulin-Dependent Protein Kinases