Amelioration of intestinal dysmotility and stasis by octreotide early after small-bowel autotransplantation in dogs.
BACKGROUND
Intestinal dysmotility and stasis after intestinal transplantation are considered to promote bacterial overgrowth and translocation. Two prokinetic agents, KW5139 (13-leu-motilin) and the somatostatin analogue octreotide acetate, were studied to determine whether they can ameliorate intestinal dysmotility during the early postoperative period.


METHODS
Motility was recorded by multiple extraluminal strain-gauge transducers in 6 dogs on postoperative days 1, 3, 7, and 14. A barium meal study was performed with a separate group of 8 dogs on postoperative days 3 and 7.


RESULTS
The agent KW5139 induced brief, weak contractions in the graft and had little effect on the dilated bowel; however, octreotide induced motor activity that propelled accumulated intestinal contents into the colon and reduced dilation of the transplanted bowel.


CONCLUSIONS
Octreotide, but not KW5139, ameliorates intestinal dysmotility associated with bowel autotransplantation during the early postoperative period. Short-term administration of octreotide may be useful for the treatment of dysmotility following intestinal transplantation.
Nakada
K
K
Department of Surgery, Pittsburgh Transplantation Institute, University of Pittsburgh, School of Medicine.
Ikoma
A
A
Suzuki
T
T
Reynolds
J C
JC
Campbell
W L
WL
Todo
S
S
Starzl
T E
TE
D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007418:Intestinal Pseudo-Obstruction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D007421:Intestine, Small / Q000637:transplantation*; D008297:Male; D009037:Motilin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D015282:Octreotide / Q000494:pharmacology* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D011859:Radiography; D013997:Time Factors; D014182:Transplantation, Autologous
D009037:Motilin; C013087:13-Leu-motilin; D015282:Octreotide