Effects of 5-fluorouracil derivatives on papillomas induced by application of 7,12-dimethylbenz(a)anthracene in mice.
We examined the effects of an application of 5-fluorouracil (5-FU) ointment and a chronic oral administration of 1-(2-tetrahydrofuryl)-5-FU plus uracil (UFT) on 7,12-dimethyl-benz(a)-anthracene-induced squamous cell papillomas in mice. Although application of 5-FU ointment reduced the growth of papillomas slightly, chronic oral administration of UFT could prevent tumorigenesis and suppress the growth of papillomas, resulting in the reduction of the tumorous viability and DNA synthesis.
Sakamoto
S
S
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Matsubara
M
M
Kudo
H
H
Suzuki
S
S
Liu
L
L
Nakayama
T
T
Mitamura
T
T
Nagasawa
H
H
D015127:9,10-Dimethyl-1,2-benzanthracene; D000284:Administration, Oral; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D004032:Diet; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D007536:Isomerism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009824:Ointments; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000378:metabolism
D016588:Anticarcinogenic Agents; D009824:Ointments; D005641:Tegafur; D015127:9,10-Dimethyl-1,2-benzanthracene; C025404:3-FT; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D005472:Fluorouracil