title: Caffeine and smoking: subjective, performance, and psychophysiological effects.
abstract: The effects of caffeine and smoking on cognitive performance, subjective variables, heart rate, and EEG were assessed in two sessions. In one session, subjects received caffeine (2.5 mg/kg bodyweight), while in the other they received placebo. In both sessions they smoked a cigarette (8 cued puffs) having a nicotine yield of 1.2 mg. Caffeine produced an increase in self-reported muscular tension and tended to increase anxiety and delta magnitude. Smoking facilitated performance of a paper-and-pencil math task and increased heart rate. Smoking also appeared to produce cortical activation as indexed by decreased right frontal delta, decreased right centro-parietal theta, globally increased alpha, and increased centro-occipital/decreased posterior-temporal beta 1. Smoking also increased central/decreased posterior-temporal beta 2. Smoking and caffeine did not interact for any measure, suggesting that the epidemiological link between smoking and coffee drinking may have a non-pharmacological basis.
authors.affiliation: Psychophysiology Laboratory, Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102.
authors.forename: W S
authors.initials: WS
authors.lastname: Pritchard
authors.forename: J H
authors.initials: JH
authors.lastname: Robinson
authors.forename: J D
authors.initials: JD
authors.lastname: deBethizy
authors.forename: R A
authors.initials: RA
authors.lastname: Davis
authors.forename: M F
authors.initials: MF
authors.lastname: Stiles
mesh_terms: D000328:Adult; D001007:Anxiety / Q000523:psychology; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects*; D001931:Brain Mapping; D002110:Caffeine / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects; D004311:Double-Blind Method; D004357:Drug Synergism; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine / Q000494:pharmacology; D011340:Problem Solving / Q000187:drug effects*; D012907:Smoking / Q000523:psychology*
chemical_list: D002110:Caffeine; D009538:Nicotine