title: Postnatal neurophysiologic effects of prenatal X-irradiation.
abstract: Histological and neurophysiological effects of in utero irradiation were examined following exposure of pregnant Wistar rat to 2.0 Gy X-irradiation or sham-irradiated on the 17th day of gestation. The 234 newborns were monitored for the age of appearance of four selected physiologic markers and the age of acquisition of five selected reflexes. Offspring were evaluated as young adults using selected behavioural tests. Postnatal growth was monitored weekly. Selected offspring were autopsied to determine the presence of morphologic central nervous system alterations. The results indicated that 2.0 Gy X-irradiation during the foetal period in rat gestation caused permanent alterations in the mature adult organism, which include non-recuperable growth retardation, morphologic changes in the brain such as microcephaly, abnormal cerebellar cortical cellular patterns, and alterations in the cell architecture of the hippocampus; diminished attainment of selected reflexes; alterations in the appearance of selected physiologic markers; and changes in adult test performance indicating significant hyperactivity among the irradiated offspring. Such exposure to X-irradiation during this period results in behavioural and morphologic alterations, which persist throughout life.
authors.affiliation: Department of Anatomy, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107-6799.
authors.forename: R P
authors.initials: RP
authors.lastname: Jensh
authors.forename: L M
authors.initials: LM
authors.lastname: Eisenman
authors.forename: R L
authors.initials: RL
authors.lastname: Brent
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D006128:Growth / Q000528:radiation effects; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D014965:X-Rays