Effects of liuwei dihuang wan [symbol: see text:bd and some other TCM drugs on bone biomechanics and serum 25 (OH)D3 content in rats.
After a relatively long-term injection of hydrocortisone into rats, the strength of bone (anti-stress capacity) reduced evidently, while the rigidity (anti-deformity capacity) increased markedly (ie, bone fragility elevated). At the same time, the content of serum 25(OH)D3 decreased remarkably. After oral administration of Liuwei Dihuang Wan ([see symbol: see text]), anti-stress capability of bone increased evidently and its anti-deformity capability returned to normal; however, there was no elevation of serum 25(OH)D3 content. The effect of Longmu Zhuanggu Chongji ([see symbol: see text]) or Jisheng Shenqi Wan (see symbol: see text]) was lower than that of Liuwei Dihuang Wan. The experiments suggests that Liuwei Dihuang Wan is beneficial to preventing and curing osteoporosis, but no correlation between its mechanism and the metabolism of 25(OH)D3 was demonstrated.
Chen
Y
Y
Institute of Orthopedics and Traumatology, China Academy of Traditional Chinese Medicine, Beijing.
Qu
C
C
Zhong
H
H
Xue
Y
Y
Zhou
C
C
Li
W
W
Cheng
X
X
D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000187:drug effects*; D002112:Calcifediol / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D002112:Calcifediol; D006854:Hydrocortisone