title: [Significance of cyclic nucleotides in pathogenesis of cor pulmonale in tuberculosis of respiratory organs and the use of beta adrenoblockers].
abstract: Blood levels of cyclic nucleotides and their actions on central hemodynamics were studied in 129 patients with pulmonary tuberculosis. A direct correlation was established between heart rate, pulmonary artery systolic pressure and concentrations of cyclic adenosine monophosphate. Basing on this finding, the authors propose introduction of beta-adrenoblockers in hyperkinetic circulation tuberculous patients to prevent cor pulmonale. Administration of anapriline in tuberculous patients with compensated cor pulmonale and symptoms of sympathoadrenal hyperfunction improves the patients' condition, promotes a decrease in cardiac output, cardiac index, systolic pressure in the pulmonary artery. No side effects of the drug were reported.
authors.forename: A I
authors.initials: AI
authors.lastname: Ershov
authors.forename: V A
authors.initials: VA
authors.lastname: Tikhonov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Evstaf'ev
authors.forename: S I
authors.initials: SI
authors.lastname: Sharunov
authors.forename: A P
authors.initials: AP
authors.lastname: Grigaliunas
authors.forename: I N
authors.initials: IN
authors.lastname: Rodina
mesh_terms: D000328:Adult; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000009:adverse effects / Q000627:therapeutic use*; D011660:Pulmonary Heart Disease / Q000209:etiology* / Q000517:prevention & control; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications* / Q000503:physiopathology
chemical_list: D011433:Propranolol; D000242:Cyclic AMP; D006152:Cyclic GMP
vernacular_title: Znachenie tsiklicheskikh nukleotidov v patogeneze legochnogo serdtsa pri tuberkuleze organov dykhaniia i primenenii beta-adrenoblokatorov.