Insights into erythroid differentiation obtained from studies on avian erythroblastosis virus.
Analysis of the oncogenes v-erbB and v-erbA and their normal proto-oncogene counterparts has revealed several novel aspects of erythroid differentiation. A new erythroid progenitor capable of extended self-renewal has been described, tyrosine kinase receptors and steroid hormone receptors have been found to cooperate in controlling self-renewal, and dramatic alterations in the cell cycle have been found to accompany induction of terminal differentiation.
Beug
H
H
Institute of Molecular Pathology, Vienna, Austria.
Müllner
E W
EW
Hayman
M J
MJ
D001355:Alpharetrovirus / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002453:Cell Cycle; D002472:Cell Transformation, Viral; D002645:Chickens; D004920:Erythropoiesis / Q000502:physiology*; D018776:Genes, erbA; D018815:Genes, erbB; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D011960:Receptors, Estrogen / Q000502:physiology; D014158:Transcription, Genetic
D011960:Receptors, Estrogen; D020794:Receptor Protein-Tyrosine Kinases