title: Delayed luteolysis and suppression of testosterone secretion after recombinant ovine interferon treatment in goats (Capra hircus).
abstract: Oxytocin at a dose of 100 iu injected s.c. daily into goats (Capra hircus) between day 3 and day 6 of the oestrous cycle caused a significant increase in testosterone secretion and luteolysis compared with saline-treated animals. Intrauterine administration of recombinant ovine interferon tau (80, 160 or 320 micrograms day-1) between days 12 and 18 of the oestrous cycle, or concomitantly (80 micrograms day-1) with oxytocin between day 3 and day 7, delayed luteolysis and blocked the increased release of testosterone. It is suggested that recombinant ovine interferon tau can act as an antiluteolytic agent in goats.
authors.affiliation: College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Saudi Arabia.
authors.forename: A M
authors.initials: AM
authors.lastname: Homeida
authors.forename: A I
authors.initials: AI
authors.lastname: al-Afaleq
mesh_terms: D000279:Administration, Cutaneous; D000287:Administration, Topical; D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism*; D005260:Female; D006041:Goats / Q000502:physiology*; D007370:Interferon Type I / Q000008:administration & dosage / Q000494:pharmacology*; D003341:Luteolysis / Q000187:drug effects*; D010121:Oxytocin / Q000494:pharmacology; D011257:Pregnancy Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013739:Testosterone / Q000097:blood / Q000378:metabolism*
chemical_list: D007370:Interferon Type I; D011257:Pregnancy Proteins; D011994:Recombinant Proteins; C020947:interferon tau; D012710:Serum Albumin, Bovine; D013739:Testosterone; D011374:Progesterone; D010121:Oxytocin