title: Treatment of nephrotic syndrome.
abstract: There are well defined therapeutic protocols for childhood nephrotic syndrome. Appropriate therapy helps in minimizing side effects besides decreasing referrals to tertiary care centres. We have analysed the appropriateness of therapy of primary care physicians in 111 children with nephrotic syndrome referred to our Institute from January 1989 to December 1991. Prednisone was administered in adequate doses in 51 (52.6%), and for adequate duration in 41 children (42.2%). Adjunctive cyclophosphamide therapy was administered in the recommended doses and duration in 33% of the cases. On evaluation of the therapy it was observed that inappropriate treatment had been administered by 39.4% of the pediatricians, 59% of internists and 80% of general practitioners. This study highlights the lacunae in the current state of knowledge amongst the primary physicians and highlights the need for creating greater awareness regarding the therapy of children with nephrotic syndrome.
authors.affiliation: Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow.
authors.forename: S
authors.initials: S
authors.lastname: Gulati
authors.forename: V
authors.initials: V
authors.lastname: Kher
authors.forename: R
authors.initials: R
authors.lastname: Elhence
authors.forename: P
authors.initials: P
authors.lastname: Kumar
authors.forename: R K
authors.initials: RK
authors.lastname: Sharma
authors.forename: A
authors.initials: A
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004358:Drug Therapy; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D010820:Physicians; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D011361:Professional Competence; D012008:Recurrence
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone