A human descendant of the chicken cardiac morphogenic protein ES/130.
We report a striking amino-acid sequence similarity between a chicken extracellular matrix protein termed ES/130, involved in early cardiac morphogenesis [Rezaee et al., J. Biol. Chem. 268 (1993) 14404-14411], and a novel human protein termed CG-1, isolated from the glycoprotein fraction of peripheral blood leukocytes [Print et al., Gene 144 (1994) 221-228]. These two proteins may be homologues which have evolved over a period of 270 x 10(6) years.
Print
C G
CG
Department of Molecular Medicine, University of Auckland, New Zealand.
Krissansen
G W
GW
D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D001798:Blood Proteins / Q000032:analysis / Q000235:genetics*; D002645:Chickens; D016326:Extracellular Matrix Proteins / Q000032:analysis / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D030161:Avian Proteins; D001798:Blood Proteins; C081857:ES-130 protein, Gallus gallus; D016326:Extracellular Matrix Proteins; C088547:KTN1 protein, human; D008565:Membrane Proteins