title: [An autopsy case of Sjögren syndrome with organized and fresh subdural hemorrhage (hematoma)].
abstract: An autopsy case of Sjögren syndrome with organized and fresh subdural hemorrhages (hematoma) is reported. A 49-year-old woman who had been suffering from Sjögren syndrome had gradually lost her consciousness and was taken to the hospital where she died several hours later. Subsequently a doctor found the subdural hematoma of unknown origin on her Brain CT. At autopsy, her skin was dry and all of her teeth were missing. There were sporadic cutaneous purpura and subcutaneous hemorrhages in her trunk and limbs. The histopathological examination revealed that the submandibular gland had no normal acini, and was replaced by fibrous and adipose tissues with numerous lymphocytes. There were signs of fibrosis with inflammation in her liver, kidneys and lungs. The thyroid gland showed thyroiditis. Serological findings showed a significant high level of antinuclear antibody, positive RA factor and high gamma-globulinemia. The autopsy revealed that her cause of death was acute subdural hematoma and uncal herniation. There were no external injuries on her head or face. It is suggested that her acute subdural hematoma according to the hemorrhagic tendency, affected by her Sjögren syndrome.
authors.affiliation: Department of Legal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Orihara
authors.forename: S
authors.initials: S
authors.lastname: Kubo
authors.forename: O
authors.initials: O
authors.lastname: Kitamura
authors.forename: R
authors.initials: R
authors.lastname: Tsuda
authors.forename: W
authors.initials: W
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: I
authors.initials: I
authors.lastname: Nakasono
mesh_terms: D000208:Acute Disease; D005260:Female; D006408:Hematoma, Subdural / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology*