title: Antimicrobial resistance of Shigella isolates causing traveler's diarrhea.
abstract: Shigella isolates were identified as a cause of traveler's diarrhea in 67 (10%) of 675 patients and were tested for resistance to seven antimicrobial agents in a comparative study with those causing nontraveler's diarrhea in Spain. Ampicillin and chloramphenicol resistance was more frequent in Shigella flexneri (60 and 46%, respectively) than in Shigella sonnei (32 and 18%, respectively) and in travel-related isolates (P < 0.05 and 0.04, respectively). Of S. sonnei isolates from patients with traveler's diarrhea, 73 and 54% showed tetracycline and trimethoprim-sulfamethoxazole resistance, respectively, compared with only 8% of isolates from patients without a history of travel to developing countries (P < 0.007 and P < 0.0002). Low-level resistance to cephalosporins was found, whereas quinolone-resistant strains were not detected among travel-related Shigella isolates. Thus, quinolones may be an effective alternative therapy for travel-related shigellosis.
authors.affiliation: Department of Microbiology, University of Barcelona, School of Medicine, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vila
authors.forename: J
authors.initials: J
authors.lastname: Gascon
authors.forename: S
authors.initials: S
authors.lastname: Abdalla
authors.forename: J
authors.initials: J
authors.lastname: Gomez
authors.forename: F
authors.initials: F
authors.lastname: Marco
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.forename: M
authors.initials: M
authors.lastname: Corachan
authors.forename: T
authors.initials: T
authors.lastname: Jimenez de Anta
mesh_terms: D003906:Developing Countries; D003967:Diarrhea / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D006801:Humans; D012760:Shigella / Q000187:drug effects* / Q000302:isolation & purification; D013030:Spain; D014195:Travel