title: Maturation of the GFAP-immunopositive glial network is delayed in the olfactory bulbs of rats subjected to early, low-dose X-irradiation.
abstract: Young rats were subjected to low-level, repeated doses of x-irradiation from a Co60 source and examined for the presence and arrangement of their GFAP-immunopositive system at the light and electron microscopic levels. In 2-week-old control rats, labelled cells were already distributed homogeneously throughout the bulb, while in the experimental animals, a (newborn- and early postnatal-type) radial arrangement of immunoreactive fibres continued to persist even until the end of the fourth postnatal week. This delay in the maturation of the GFAP-immunopositive glial system may contribute to the hindered development of the bulbar neurones, neuronal connections, and field potentials, as found in earlier studies.
authors.affiliation: Department of Anatomy and Histology, University of Veterinary Science, Budapest, Hungary.
authors.forename: F
authors.initials: F
authors.lastname: Hajós
authors.forename: M
authors.initials: M
authors.lastname: Mészáros
authors.forename: N
authors.initials: N
authors.lastname: Halász
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000378:metabolism*; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D009412:Nerve Fibers / Q000502:physiology* / Q000528:radiation effects / Q000648:ultrastructure; D009457:Neuroglia / Q000502:physiology* / Q000528:radiation effects / Q000648:ultrastructure; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D014965:X-Rays
chemical_list: D005904:Glial Fibrillary Acidic Protein