Varicella-zoster virus (VZV) transcription during latency in human ganglia: prevalence of VZV gene 21 transcripts in latently infected human ganglia.
Reverse transcriptase-linked PCR was used to determine the prevalence of varicella-zoster virus (VZV) gene 21 transcription in latently infected human ganglia. Under conditions wherein reverse transcriptase-linked PCR detected > or = 1,000 transcripts, VZV gene 21 RNA, but not VZV gene 40 RNA, was found in ganglia but not other tissues from five of seven humans.
Cohrs
R J
RJ
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262.
Barbour
M B
MB
Mahalingam
R
R
Wellish
M
M
Gilden
D H
DH
D001483:Base Sequence; D017931:DNA Primers; D005724:Ganglia / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000235:genetics*; D017735:Virus Latency
D017931:DNA Primers; D012333:RNA, Messenger; D014764:Viral Proteins