Neurodegenerative disease. Oxidative stress and motorneuron disease.
Transgenic mice carrying mutated Cu/Zn superoxide dismutase genes provide insights into the pathogenesis of human motorneuron diseases and may be useful as models in the development and testing of therapies.
Sendtner
M
M
Department of Neurochemistry, Max-Planck-Institut for Psychiatry, Martinsried, Germany.
Thoenen
H
H
D000690:Amyotrophic Lateral Sclerosis / Q000628:therapy; D000818:Animals; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008958:Models, Molecular; D015394:Molecular Structure; D016472:Motor Neuron Disease / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D009410:Nerve Degeneration; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D013482:Superoxide Dismutase