title: Platelet activation in major surgical stress: influence of combined epidural and general anaesthesia.
abstract: Platelets are activated in surgery releasing vasoactive substances such as serotonin and thromboxane. Platelets become temporarily hypoaggregable during surgery followed by a postoperative hyperaggregability. Local anaesthetics are known to inhibit platelet function but earlier reports are conflicting. In order to study the impact of the combined use of general and regional anaesthesia on platelet function during major surgery 16 otherwise healthy patients were randomised to either general anaesthesia (GA) (n = 8) or GA combined with epidural anaesthesia (GA+EPI) (n = 8) for elective upper abdominal surgery. Cyclic 3',5' adenosine monophosphate, plasma glucose, plasma cortisol and the rate pressure product (RPP) were markers of the stress response. ADP-induced platelet aggregation and the release products beta-thromboglobulin, serotonin and thromboxane 2 were measured in plasma before and during as well as for 3 days after surgery. A marked stress response was noted in both groups and epidural anaesthesia (EPI) only reduced the rate pressure product (RPP). Platelet aggregation was reduced during surgery, a little more so in the GA+EPI group. Postoperatively both groups showed significant hyperaggregability. The release products were not significantly influenced by regional anaesthesia. In conclusion epidural as combined with general anaesthesia affects platelet responses to major abdominal surgery only to a minor extent, although it may attenuate the haemodynamic response.
authors.affiliation: Department of Anaesthesia and Intensive Care, University of Gothenburg, Sahlgren's Hospital, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Naesh
authors.forename: I
authors.initials: I
authors.lastname: Hindberg
authors.forename: J
authors.initials: J
authors.lastname: Friis
authors.forename: C
authors.initials: C
authors.lastname: Christiansen
authors.forename: T
authors.initials: T
authors.lastname: Pedersen
authors.forename: J
authors.initials: J
authors.lastname: Trap-Jensen
authors.forename: J O
authors.initials: JO
authors.lastname: Lund
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D001786:Blood Glucose / Q000032:analysis; D001792:Blood Platelets / Q000378:metabolism; D001794:Blood Pressure; D002763:Cholecystectomy / Q000009:adverse effects; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006339:Heart Rate; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D015539:Platelet Activation; D010974:Platelet Aggregation / Q000187:drug effects; D012701:Serotonin / Q000097:blood; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D001786:Blood Glucose; D001620:beta-Thromboglobulin; D012701:Serotonin; D000244:Adenosine Diphosphate; D000242:Cyclic AMP; D006854:Hydrocortisone