title: [Increased viability of skin flaps using naftidrofuryl. An experimental study in the Wistar rat].
abstract: The effect of a vasodilator (naftidrofuryl) was evaluated in an experimental study in rats concerning the viability of a skin flap. The reference flap is a dorsal skin flap deliberately shaped very long in order to obtain necrosis of its distal extremity. This necrosis is measurable and sufficiently reproducible. Using a comparative study between a control group of ten rats and a group of rats treated by intraperitoneal injections of naftidrofuryl for ten days, the authors demonstrated a significant difference between necrosis in the two groups. Naftidrofuryl treatment increases the length of the viable part of the skin flap in rats. This product achieves a kind of medicinal autonomy much easier than a surgical autonomy.
authors.affiliation: Laboratoire de Microchirurgie, Hôpital Saint-Antoine, Paris.
authors.forename: I
authors.initials: I
authors.lastname: Cothier-Savey
authors.forename: M
authors.initials: M
authors.lastname: Mimoun
authors.forename: S
authors.initials: S
authors.lastname: Baux
mesh_terms: D000818:Animals; D009257:Nafronyl / Q000494:pharmacology*; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D012107:Research Design; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013524:Surgical Flaps
chemical_list: D009257:Nafronyl
vernacular_title: Augmentation de la viabilité des lambeaux cutanés par l'utilisation du naftidrofuryl. Etude expérimentale chez le rat Whistar.