title: The role of ATP as a mediator in the action of iron complexes on cellular calcium homeostasis.
abstract: The effects of the interaction between low molecular weight iron complexes (citrate, lactate, and ATP complexes) with ATP and proteins, on the modification of Ehrlich carcinoma cell calcium homeostasis have been studied. In that modification the ferric-ATP complex shows much higher activity than the others. Sodium ATP, by iron translocation from citrate and lactate, increases their activity. This phenomenon implicates ATP as a mediator on the cellular activity of the complexes. Proteins, particularly ferritin, appear to moderately reduce their activity, whereas glutathione and ascorbic acid, acting as lipid peroxidation-inhibitors, show only a slight reduction of the iron complex's effects on cellular calcium uptake.
authors.affiliation: Laboratoire de Biophysique, Nancy, France.
authors.forename: L J
authors.initials: LJ
authors.lastname: Anghileri
authors.forename: P
authors.initials: P
authors.lastname: Maincent
authors.forename: A
authors.initials: A
authors.lastname: Cordova Martinez
authors.forename: P
authors.initials: P
authors.lastname: Thouvenot
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D005290:Ferric Compounds / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects*; D007501:Iron / Q000493:pharmacokinetics / Q000494:pharmacology; D007504:Iron Radioisotopes; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D051379:Mice
chemical_list: D005290:Ferric Compounds; D007504:Iron Radioisotopes; D007773:Lactates; D019344:Lactic Acid; C025314:ferric citrate; D000255:Adenosine Triphosphate; D007501:Iron; D000251:Adenosine Triphosphatases; D005978:Glutathione; D001205:Ascorbic Acid; D002118:Calcium