Rapid nuclear actions of growth hormone.
The mechanisms by which growth hormone (GH) initiates its effect on growth are largely unknown. In this report we examine the acute actions of GH with a focus on the intracellular signaling pathways leading from the cell-surface GH receptor into the nucleus, and culminating in the activation of specific target genes. We show that in vivo GH treatment leads to the rapid appearance of tyrosine-phosphorylated nuclear proteins and the equally rapid induction of c-fos and insulin-like growth factor I gene transcription. A model is proposed for a GH-activated intracellular signal transduction pathway.
Rotwein
P
P
Department of Medicine and Biochemistry, Washington University School of Medicine, St. Louis, MO 63110.
Gronowski
A M
AM
Thomas
M J
MJ
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D013006:Growth Hormone / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D011986:Receptors, Somatotropin / Q000378:metabolism; D015398:Signal Transduction
D009687:Nuclear Proteins; D011986:Receptors, Somatotropin; D013006:Growth Hormone