A digital brain atlas and its application to the visceral neuraxis.
We describe the details and application of a digital brain atlas for the comparison and integration of graphical neurobiological data. The atlas consists of multiple sets of high-resolution video images acquired from histological tissue sections representing a 3-dimensional (3D) volume of an exemplar rat brain. Through an interactive graphical interface running on a standard computer workstation, experimental data is brought into register with the atlas. Once in the atlas, coordinate reference frame data can be compared, analyzed, and visualized in 3 dimensions. We demonstrate the validity and usefulness of the digital brain atlas with a series of results on the visceral neuraxis in the rat.
Funka-Lea
G D
GD
Neural Computahon Group, E. 1. DuPont de Nemours, Wilmington, DE 19880-0328.
Schwaber
J S
JS
D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D003198:Computer Simulation; D006652:Histological Techniques; D008279:Magnetic Resonance Imaging; D009446:Neurobiology / Q000295:instrumentation / Q000379:methods; D009474:Neurons / Q000166:cytology / Q000502:physiology; D051381:Rats; D012984:Software; D014741:Video Recording