Therapeutic effect of an anti-HIV candidate vaccine.
A chimpanzee infected with the HIV since 8 months and presenting regularly with antigenemia was inoculated with a candidate vaccine. It received 3 doses, one dose every 15 days. Thirty days after the third injection, we noted the disappearance of the HIV antigens in the serum and its persistence in the lysate of the cells. We noted also a strong precipitation reaction both in the tube and in the gel between the antibodies and the antigens released by the lysis of the cells. The analysis of this precipitate demonstrated that it was constituted of immune complexes in which the antibodies were of high affinity. At the 240th day after the third injection of the candidate vaccine we noted the disappearance of the HIV antigens in the lysate of cells as well. From these results, we conclude that the candidate vaccine we tested can elicit high affinity antibodies able to clear the HIV antigens and destroy the cells containing the HIV antigens probably with the help of specific killer cells.
Lurhuma
Z
Z
Laboratoire d'Immunologie, KINSHASA XI Republique du Zaire.
Wane
J
J
Mbayo
K
K
Karhemere
B
B
D016915:AIDS Vaccines / Q000627:therapeutic use*; D000818:Animals; D000915:Antibody Affinity; D000936:Antigen-Antibody Complex; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D015488:HIV Antigens / Q000097:blood*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D002679:Pan troglodytes
D016915:AIDS Vaccines; D000936:Antigen-Antibody Complex; D015488:HIV Antigens