Effects of human epidermal growth factor on passive avoidance and habituation learning in mice.
1. Human epidermal growth factor (hEGF:0.02-2.0 micrograms) did not affect passive avoidance response or habituation learning when given before or immediately after training, or before retention. 2. hEGF (0.02-2.0 micrograms) failed to influence the scopolamine- or electroconvulsive shock-induced shortening of step-down latency in passive avoidance response when given before or immediately after training, or before retention. 3. These results suggest that the acute administration of hEGF does not affect memory processes as indexed by passive avoidance or habituation learning in normal or amnesic mice.
Ukai
M
M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Miura
M
M
Kameyama
T
T
D000647:Amnesia / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D011930:Reaction Time
D004815:Epidermal Growth Factor