Abrogation of accelerated allograft rejection by intrathymic injection of donor spleen cells is associated with upregulation of donor-reactive IgM, IgG1, and IgG2A, but depression of IgG2B in the circulation and at the graft site.
Binder
J
J
Department of Surgery, Harvard Medical School, Boston, MA 02115.
Hancock
W W
WW
Watschinger
B
B
Wasowska
B
B
Sayegh
M H
MH
Kupiec-Weglinski
J W
JW
D000818:Animals; D000911:Antibodies, Monoclonal; D000917:Antibody Formation; D003433:Crosses, Genetic; D005434:Flow Cytometry; D006085:Graft Survival / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood / Q000145:classification; D007075:Immunoglobulin M / Q000096:biosynthesis* / Q000097:blood; D007518:Isoantibodies / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood; D007959:Lymphocyte Culture Test, Mixed; D017710:Lymphocyte Transfusion; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF; D016038:Skin Transplantation / Q000276:immunology*; D013154:Spleen; D013950:Thymus Gland
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies