title: [Animal experiment studies on CO2 laser stapedotomy].
abstract: Experiments were performed in guinea pigs to clarify which, if any, of the CO2 lasers used can damage the inner ear on application of the laser parameters required for stapedotomy. A further aim was to determine their application safety. The basal convolution of the guinea-pig cochlea was chosen as the application site, since its thickness is similar to that of the human stapes base. We examined the laser effect in connection with perforation of the basal convolution and subsequent application in the open cochlea. Acoustic evoked potentials (compound action potentials [CAP]) yielded information on inner-ear function. Animals without laser treatment were used as controls. Perforation of the basal convolution and laser applications in the open cochlea with the same parameters did not lead to a measurable CAP alteration with the CO2 cw laser (power: 8 W, pulse duration: 50 ms, power density: 3200 W/cm2). An increase of the laser power to 15 W (power density: 6000 W/cm2) and of the pulse duration to 200 and 500 ms (energy: 3 J and 7.5 J) caused partly irreversible CAP alterations; finally, no potential could be recorded any more at a maximal laser power and pulse duration (15 W and 500 ms). Examination of high power densities (40,000 and 60,000 W/cm2) through reduction of the laser beam diameter to 180 microns yielded comparable results.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hals-Nasen-Ohrenklinik mit Polikliniken im Klinikum Benjamin Franklin, Freien Universität Berlin.
authors.forename: S
authors.initials: S
authors.lastname: Jovanovic
authors.forename: D
authors.initials: D
authors.lastname: Anft
authors.forename: U
authors.initials: U
authors.lastname: Schönfeld
authors.forename: A
authors.initials: A
authors.lastname: Berghaus
authors.forename: H
authors.initials: H
authors.lastname: Scherer
mesh_terms: D000818:Animals; D001305:Auditory Fatigue / Q000502:physiology; D007758:Ear, Inner / Q000293:injuries* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D053685:Laser Therapy / Q000295:instrumentation*; D011930:Reaction Time / Q000502:physiology; D013201:Stapes Surgery / Q000295:instrumentation*
vernacular_title: Tierexperimentelle Untersuchungen zur CO2-Laser-Stapedotomie.