title: Unusual case of corticobasal degeneration with tau/Gallyas-positive neuronal and glial tangles.
abstract: A 74-year-old woman with corticobasal degeneration (CBD) had a 9-year history of progressive loss of strength and rigidity of her right hand and then arm, followed by speech difficulties, dyskinesia, rigidity, spasticity and weakness of the ipsilateral lower limb, ultimately also involving the opposite side. She later developed supranuclear gaze palsy. Her memory remained intact during most of the duration of her disease. Laboratory tests and anti-Parkinsonian medications were not helpful. At autopsy, frontal lobe atrophy, discoloration of putamen (Pt) and pallor of substantia nigra (Sn) were observed. Neuronal loss and gliosis were extensive in motor cortex and milder in frontal cortex, abruptly ending at the central sulcus and junction of cingulate gyrus. "Achromatic" neurons were present. Neuronal loss and gliosis were seen in Pt and Sn and corticobasal inclusions in Sn. Numerous Gallyas/tau-positive, Bielschowsky/ubiquitin-negative coil, sickle, or coma-shaped tangles and thread-like processes were found in affected cortex, Pt and Sn. Some of the tangles were in neurons, but most occurred in astroglia, and their processes. The presence of Gallyas/tau-positive glia in CBD may have the same diagnostic significance as in progressive supranuclear palsy, analogous to the argyrophilic ubiquinated inclusions in oligodendroglia in multisystem atrophy. We suggest that in CBD: (1) cytoskeletal protein metabolism in neurons and glia can simultaneously be perturbed in certain neurodegenerative diseases, and (2) the astrocytosis in CBD may not be simply a reactive process but an integral part of the disease.
authors.affiliation: Department of Pathology/Neuropathology, Stanford University School of Medicine, CA 94305-5324.
authors.forename: D S
authors.initials: DS
authors.lastname: Horoupian
authors.forename: P L
authors.initials: PL
authors.lastname: Chu
mesh_terms: D000368:Aged; D001480:Basal Ganglia Diseases / Q000378:metabolism / Q000473:pathology*; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000737:chemistry / Q000473:pathology*; D003584:Cytological Techniques; D005260:Female; D006801:Humans; D009457:Neuroglia / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis
chemical_list: D016875:tau Proteins