[Erythrocyte superoxide dismutase (eSOD) determination in positive moments of psychosis].
Dysregulation of free radical metabolism has been supposed to be involved in schizophrenia etiopathogeny. Recently, Wang et al. showed a red blood cell super oxide dismutase increase in positive schizophrenia (Crow's type I), but neither in negative schizophrenia (Crow's type II) nor in controls. The study included 28 in-patients suffering from acute positive psychosis who were compared with 15 controls. We confirmed the results of Wang. We found a significantly red blood cell Super oxide dismutase increase in positive psychosis, in comparison to negative psychosis and controls (p = 0.0001). This SOD increase was in relationship with the degree of clinical psychomotor excitement. After 21 days of neuroleptic treatment, SOD activity decreased and reached standard values. These results support the hypothesis of striking relationships between catecholaminergic hyper-metabolism and SOD increase, in positive psychosis. These could account for psychotic positive symptoms improvement with neuroleptic treatment, which blocks dopamine pathways.
Vaiva
G
G
Service de Psychiatrie Générale, USN B, CHRU de Lille.
Thomas
P
P
Leroux
J M
JM
Cottencin
O
O
Dutoit
D
D
Erb
F
F
Goudemand
M
M
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000097:blood* / Q000188:drug therapy; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy; D013482:Superoxide Dismutase / Q000097:blood*
D014150:Antipsychotic Agents; D013482:Superoxide Dismutase
Dosages de la superoxyde dismutase érythrocytaire (SODe) dans les moments productifs de psychose.