Effect of albendazole on Ancylostoma caninum larvae migrating in the muscles of mice.
When mice inoculated with 1,000 third-stage larvae of Ancylostoma caninum for 1 week were treated intragastrically (ig) with albendazole (Alb) 75, 150 or 300 mg/kg.d for 3 days, the mean larva numbers collected from the muscles of each group were 2.7 +/- 1.7, 2.0 +/- 1.5 and 1.0 +/- 1.0, respectively, being much less than that 205 +/- 68 of the control group. In mice treated ig with Alb 150 mg/kg.d for 3 days, the concentrations of Alb and its effective metabolite, albendazole sulfoxide (AlbSO), were determined in plasma and the muscles at different intervals after the last medication using high performance liquid chromatography. The results showed that only low concentrations of Alb were detected in both plasma and the muscles. However, higher concentrations of AlbSO were found not only in the plasma (5.4-10.5 micrograms/ml), but also in the muscles (2.2-4.6 micrograms/g). The higher contents of AlbSO in the muscles would be helpful for killing the Ancylostoma larvae migrating in the muscles of mice.
Xiao
S
S
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine (WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis), Shanghai.
Ren
H
H
You
J
J
Zhao
L
L
Li
B
B
Zhang
C
C
D015766:Albendazole / Q000031:analogs & derivatives / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000722:Ancylostoma / Q000187:drug effects*; D000724:Ancylostomiasis / Q000188:drug therapy*; D000818:Animals; D005260:Female; D007814:Larva / Q000187:drug effects; D007815:Larva Migrans / Q000188:drug therapy*; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism / Q000469:parasitology*
D015766:Albendazole; C027186:albendazole sulfoxide