Spreading depression of Leão in rodent and human cortex.
Spreading depression (SD) has been implicated in the pathophysiology of a number of neurological conditions. The same methodology was used to elicit SD in anesthetized rats and in non-anesthetized patients undergoing cortical resections for intractable epilepsy. A slowly spreading DC potential shift (mean -9 mV) occurred in the cortex of 10 of 15 rats in association with attenuation of the electrocorticogram but this could not be reproduced in any of the human cortices (n = 23) where the mean potential shift was -0.56 mV (P < 0.0001). SD is more difficult to elicit in human than rodent cortex and may not occur in man.
McLachlan
R S
RS
Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London, Canada.
Girvin
J P
JP
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D013181:Cortical Spreading Depression / Q000502:physiology*; D003712:Dendrites / Q000502:physiology; D004558:Electric Stimulation; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D010812:Physical Stimulation; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity