title: Multicenter study in Hungary with a 30 micrograms ethinylestradiol- and 150 micrograms desogestrel-containing monophasic oral contraceptive.
abstract: Among the countries in Central and Eastern Europe, Hungary has a high oral contraceptive prevalence rate. Until recently, however, Hungarian women have not had access to combined oral contraceptives with new, third-generation progestogens. Marvelon (30 micrograms ethinylestradiol and 150 micrograms desogestrel) was first introduced in 1981 in Western Europe and has, in a number of different studies, proven an effective and well-tolerated oral contraceptive with no effect on blood pressure and a favorable lipid profile. Marvelon was introduced in Hungary in October 1991. Prior to its introduction, a multicenter study was undertaken in Hungary with Marvelon to confirm the clinical results of studies from other countries. The present study confirmed Marvelon to be an effective, well-tolerated combined oral contraceptive with no relevant effect on blood pressure. Remarkable improvements were noted, especially with regard to side-effects, in switchers from other oral contraceptives. It is concluded that Marvelon is a valuable extension of the range of contraceptive methods available in Hungary.
authors.affiliation: NV Organon, Oss, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Bruyniks
authors.forename: L
authors.initials: L
authors.lastname: Kovacs
authors.forename: I
authors.initials: I
authors.lastname: Rákóczi
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000494:pharmacology / Q000592:standards*; D017135:Desogestrel / Q000009:adverse effects / Q000494:pharmacology / Q000592:standards*; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000494:pharmacology / Q000592:standards*; D005260:Female; D006801:Humans; D006814:Hungary; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology
chemical_list: D003277:Contraceptives, Oral, Combined; D004997:Ethinyl Estradiol; D017135:Desogestrel