title: Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis.
abstract: OBJECTIVE
  To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology.
  
  
  METHODS
  Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated.
  
  
  RESULTS
  Interleukin-8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted.
  
  
  CONCLUSIONS
  We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.
authors.affiliation: University of California, San Francisco.
authors.forename: I P
authors.initials: IP
authors.lastname: Ryan
authors.forename: J F
authors.initials: JF
authors.lastname: Tseng
authors.forename: E D
authors.initials: ED
authors.lastname: Schriock
authors.forename: O
authors.initials: O
authors.lastname: Khorram
authors.forename: D V
authors.initials: DV
authors.lastname: Landers
authors.forename: R N
authors.initials: RN
authors.lastname: Taylor
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D016022:Case-Control Studies; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D009994:Osmolar Concentration; D012016:Reference Values
chemical_list: D016209:Interleukin-8