Nitric oxide production does not directly increase macrophage candidacidal activity.
Some activated murine macrophages produced nitrite but were unable to kill Candida albicans. Furthermore, a nitric oxide (NO) generator inhibited C. albicans growth but was not candidacidal. Our results suggest that NO is candidastatic and that No is not directly involved but is associated with or induces other macrophage candidacidal mechanisms.
Vazquez-Torres
A
A
Department of Surgery, University of Wisconsin Medical School, Madison 53706-1532.
Jones-Carson
J
J
Balish
E
E
D000818:Animals; D002176:Candida albicans / Q000276:immunology*; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D009573:Nitrites / Q000378:metabolism; D009599:Nitroprusside / Q000378:metabolism
D009573:Nitrites; D009599:Nitroprusside; D009569:Nitric Oxide