Spin labeled amino acid nitrosourea derivatives--synthesis and antitumour activity.
The synthesis of three spin labeled derivatives of N-[N'-(chloroethyl)-N'-nitrosocarbamoyl] amino acids is reported. The new nitrosoureas are obtained by condensation of the corresponding N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl] amino acid with 2,2,6,6-tetramethyl-1-oxyl-4-aminopiperidine using dicyclohexylcarbodiimide. Their chemical structures are confirmed by elemental analysis, IR, MS, and EPR spectroscopy. All newly synthesized compounds showed high antitumour activity against the lymphoid leukemia L1210 in BDF1 mice.
Zheleva
A
A
Higher Medical Institute, Stara Zagora, Bulgaria.
Raikov
Z
Z
Ilarionova
M
M
Todorov
D
D
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D007939:Leukemia L1210 / Q000188:drug therapy; D013058:Mass Spectrometry; D051379:Mice; D008815:Mice, Inbred Strains; D009607:Nitrosourea Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013113:Spin Labels
D000596:Amino Acids; D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D013113:Spin Labels