Laboratory assessment of circulating anticoagulants.
Circulating anticoagulants pose challenging conceptual, technical, and interpretive problems in the laboratory. Their sound diagnosis and management depend on a clear understanding of both the in vivo and in vitro manifestations of the three classes of inhibitors (nonspecific, multispecific, and specific) and the entities therein. From the ongoing research, this field will undoubtedly continue to grow in significance and complexity, demanding ever greater laboratory expertise and competence.
Armitage
J B
JB
Department of Pathology, University of Texas Southwestern Medical Center, Dallas.
Hernandez
J A
JA
Kaplan
H S
HS
D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors; D005169:Factor VIII / Q000037:antagonists & inhibitors; D005338:Fibrin Fibrinogen Degradation Products / Q000502:physiology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D007753:Laboratories; D016682:Lupus Coagulation Inhibitor / Q000097:blood
D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D007136:Immunoglobulins; D016682:Lupus Coagulation Inhibitor; C019158:circulating anticoagulants; D005169:Factor VIII