[Comparative study of the serologic response of IgA and IgM type in the diagnosis of acute toxoplasmosis].
BACKGROUND
IgM serologic response in the diagnosis of acute toxoplasmosis presents interpretation problems. A comparative study with IgA detection of antibodies was performed.


METHODS
A parallel serologic study was carried out with IgM and IgA enzymoimmunoassay enhancement techniques in the sera of patients suspected of having toxoplasmosis.


RESULTS
Positive results for IgM and/or IgA were presented in 74 sera (47 patients): 86.3% for the former and 58.9% for the latter (p < 0.001). The group of IgA-/IgA+ sera presented a low mean of proportionality index (PI): 1.6 versus the IgM+ sera group in the context of IgG seroconversion with a PI of 3.4 (p < 0.001). Out of the 9 patients with demonstrated IgG, all were IgA+ and seven IgM+.


CONCLUSIONS
The present data seem to support greater specificity of the determination of IgA antibodies than that of IgM in the diagnosis of acute toxoplasmosis.
Lafarga
B
B
Servicio de Microbiología, Hospital Nuestra Señora del Pino, Las Palmas de Gran Canaria.
Cañas
A
A
Pérez
M C
MC
Suárez
J
J
Elcuaz
R
R
D000208:Acute Disease; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D014123:Toxoplasmosis / Q000097:blood / Q000175:diagnosis*
D007070:Immunoglobulin A; D007075:Immunoglobulin M
Estudio comparativo de la respuesta serológica del tipo IgA e IgM en el diagnóstico de la toxoplasmosis aguda.