Reinforcing effect of the D1 dopamine agonist SKF 81297 in rhesus monkeys.
Rhesus monkeys with IV catheters were allowed to self-administer cocaine for 1 h/day. When responding was stable, saline or the D1 dopamine agonist SKF 81297 (SKF; 0.001-0.3 mg/kg/inj) was substituted for cocaine. At least two doses of SKF maintained responding above saline levels in all monkeys. The D1 antagonist SCH 39166 (0.001-0.03 mg/kg, IM) was then administered 30 min before sessions of self-administration of the lowest dose of SKF that maintained behavior (0.01 mg/kg/inj). SKF-maintained responding decreased in a dose-related manner, suggesting antagonism of the reinforcing effect. These results suggest that stimulation of D1 receptors can initiate a reinforcing effect and further implicate D1 receptors in the reinforcing effects of drugs that increase dopamine neurotransmission.
Weed
M R
MR
Department of Pharmacological and Physiological Sciences, Pritzker School of Medicine, University of Chicago, IL 60637.
Vanover
K E
KE
Woolverton
W L
WL
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008253:Macaca mulatta; D017447:Receptors, Dopamine D1 / Q000819:agonists* / Q000037:antagonists & inhibitors; D012054:Reinforcement, Psychology; D012646:Self Administration; D009435:Synaptic Transmission / Q000187:drug effects
D001552:Benzazepines; D017447:Receptors, Dopamine D1; C058081:ecopipam; C067113:SK&F 81297; D003042:Cocaine