title: Synthesis and pharmacological properties of some new 3-(2-N,N-dialkylaminoethyl)-pyrido [2,3-d]-pyrymidin-4-ones.
abstract: The following new derivatives of pyrido [2,3-d]-pyrimidin-4(3H)-one were synthesized: 3-(2-N,N-dimethylaminoethyl), 3-(2-N-pyrolidynylethyl), 3-(2-piperidinylethyl) and 3-(2-N-morpholidinylethyl). Their chemical structures were confirmed by MS, IR and 1H NMR spectroscopic data. Newly synthesized compounds were investigated pharmacologically for their central properties in mice and rats. It was shown that compound [III] showed anxiolytic action in the four-plate test and two compounds produced analgesic effects in mice.
authors.affiliation: Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków.
authors.forename: T
authors.initials: T
authors.lastname: Kowalska
authors.forename: P
authors.initials: P
authors.lastname: Kowalski
authors.forename: K
authors.initials: K
authors.lastname: Rutkowski
authors.forename: M
authors.initials: M
authors.lastname: Woźniak
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: E
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
authors.forename: G
authors.initials: G
authors.lastname: Szurska
authors.forename: A
authors.initials: A
authors.lastname: Chodkowska
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D014151:Anti-Anxiety Agents; D011743:Pyrimidines