title: Canine model of acute aortic rupture: treatment with percutaneous delivery of a covered Z stent--work in progress.
abstract: OBJECTIVE
  To develop a percutaneous treatment for aortic rupture with use of a covered intraluminal stent.
  
  
  METHODS
  A transmural tear was created percutaneously in the thoracic aorta in six dogs with use of a 4-mm angioplasty balloon. Gianturco Z stents were covered with polytetrafluoroethylene, loaded into a 14-F sheath, and advanced through the femoral artery to the site of injury. Within 2 minutes after initiation of the injury, the stent was deployed. Homologous canine blood was given during the procedure. Dogs that survived 24 hours were then killed.
  
  
  RESULTS
  The first stent did not expand completely, and the dog died in 1 hour. At necropsy, the first two dogs (1-hour and 8-hour survival) had a large left hemothorax and extensive periaortic hematoma, indicating intrathoracic exsanguination. The next four dogs were treated with a modified stent and survived 2 hours (n = 1), 8 hours (n = 1), and 24 hours (n = 2). At necropsy hemothorax did not exceed 15 mL, and periaortic hematomas were small. The cause of death in the two early casualties with the modified stent is uncertain. There were no signs of spinal cord injury despite occlusion of three pairs of intercostal arteries.
  
  
  CONCLUSIONS
  The covered Z stent (in its modified form) tamponaded the aortic tear, preventing exsanguination. Long-term studies of biocompatibility of this device appear justified.
authors.affiliation: Department of Radiology, University Hospitals, University of Michigan, Ann Arbor 48109-0030.
authors.forename: D M
authors.initials: DM
authors.lastname: Williams
authors.forename: J C
authors.initials: JC
authors.lastname: Andrews
authors.forename: S S
authors.initials: SS
authors.lastname: Chee
authors.forename: M V
authors.initials: MV
authors.lastname: Marx
authors.forename: G D
authors.initials: GD
authors.lastname: Abrams
mesh_terms: D000208:Acute Disease; D000818:Animals; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000473:pathology; D001019:Aortic Rupture / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D001027:Aortography; D004285:Dogs; D011138:Polytetrafluoroethylene; D011677:Punctures; D015641:Radiography, Interventional; D015607:Stents
chemical_list: D011138:Polytetrafluoroethylene