Differentiation of follicular lymphoma cells after autologous bone marrow transplantation and haematopoietic growth factor treatment.
A patient with follicular lymphoma developed a striking but transient plasmacytosis in blood and bone marrow with paraproteinaemia after treatment by autologous bone marrow transplantation and interleukin-3 (IL-3). By immunophenotyping, cytogenetics and Southern blotting, we proved that the plasma cells were clonally related to the original lymphoma cells. This event was preceded by fever accompanied by high IL-6 concentrations. The patient recovered spontaneously and had a long-lasting remission. We speculate that the bone marrow-derived malignant B cells were stimulated by IL-3 and IL-6 into terminally differentiated plasma cells.
Kramer
M H
MH
Department of Pathology, University Medical Centre, Leiden, Netherlands.
Kluin
P M
PM
Wijburg
E R
ER
Fibbe
W E
WE
Kluin-Nelemans
H C
HC
D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood; D008224:Lymphoma, Follicular / Q000473:pathology* / Q000628:therapy*; D014182:Transplantation, Autologous
D007377:Interleukin-3; D015850:Interleukin-6