Intestinal carriage of P fimbriated Escherichia coli and the susceptibility to urinary tract infection in young children.
This prospective study analyzed the intestinal carriage of P fimbriated Escherichia coli as a host susceptibility factor in urinary tract infection (UTI). P fimbriation was defined by the pap and G adhesin (papG1A2, prsGJ96) genotypes. Children with UTI carried pap+ E. coli in the fecal flora more often than healthy controls both at diagnosis (86% vs. 29%) and during infection-free intervals (approximately 40%; P < .01). P1 blood group-positive children carried pap+ E. coli in the fecal flora more often (88%) than those with P2 blood group (40%; P < .05). A pap+ E. coli strain caused UTI in 53 of 55 patients who carried both pap+ and pap- strains in their fecal flora. These results suggest that persons who develop UTI have an increased tendency to carry pap+ E. coli in the large intestine and that these pap+ E. coli cause UTI more often than pap E. coli strains in the fecal flora of the same host.
Plos
K
K
Department of Clinical Immunology, Göteborg University, Sweden.
Connell
H
H
Jodal
U
U
Marklund
B I
BI
Mårild
S
S
Wettergren
B
B
Svanborg
C
C
D018830:Adhesins, Escherichia coli / Q000032:analysis* / Q000235:genetics; D004926:Escherichia coli / Q000302:isolation & purification*; D005243:Feces / Q000382:microbiology; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007422:Intestines / Q000382:microbiology*; D008297:Male; D010127:P Blood-Group System; D011446:Prospective Studies; D011704:Pyelonephritis / Q000382:microbiology; D014552:Urinary Tract Infections / Q000209:etiology*
D018830:Adhesins, Escherichia coli; D010127:P Blood-Group System