[Hyperthyroidism and hypersecretion of chorionic gonadotropin in gastric adenocarcinoma].
We report a case of hyperthyroidism complicating and revealing a metastatized adenocarcinoma of the stomach with high circulating levels of human chorionic gonadotropin and its beta component. To our knowledge, this is the first reported case of a non-trophoblastic tumor with hyperthyroidism and secreting quantities of these hormones. High circulating levels of beta component in such patients have been considered to be a sign of malignancy. The mechanisms of thyroid stimulation could be related to the biological activity of certain forms of the human chorionic gonadotropin.
Brousse
C
C
Service de médecine interne, CMC Foch, Suresnes, France.
Mignot
L
L
Baglin
A C
AC
Bernard
N
N
Piette
A M
AM
Gepner
P
P
Chapman
A
A
D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000150:complications / Q000378:metabolism*
D006063:Chorionic Gonadotropin
Hyperthyroïdie et hypersécrétion de gonadotrophine chorionique au cours d'un adénocarcinome gastrique.