title: Fish protein-rich diet attenuates hypertension induced by dietary NG-nitro-L-arginine in normotensive Wistar-Kyoto rats.
abstract: 1. Dietary 0.023% NG-nitro-L-arginine (L-NNA), an inhibitor of nitric oxide synthesis, induced hypertension in normotensive Wistar-Kyoto rats (WKY). This hypertension was significantly attenuated in WKY given a fish protein-rich diet. 2. The supplement of 2% L-arginine given in a standard diet or a diet containing 3% taurine for drinking did not significantly affect the development of hypertension induced by L-NNA in WKY. 3. WKY which received the standard diet mixed with 10% urea and 0.023% L-NNA had significantly attenuated hypertension compared with WKY receiving the standard diet mixed with 10% kaolin and 0.023% L-NNA. 4. These results suggest that the attenuation of hypertension in L-NNA-treated WKY rats given a fish protein rich diet may be partly caused by urea, a metabolic end-product of protein.
authors.affiliation: Department of Pathology, Shimane Medical University, Shimane Institute of Health Science, Izumo, Japan.
authors.forename: O G
authors.initials: OG
authors.lastname: Gutierrez
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Nara
authors.forename: G U
authors.initials: GU
authors.lastname: Deguan
authors.forename: Y
authors.initials: Y
authors.lastname: Yamori
mesh_terms: D000818:Animals; D001120:Arginine / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D004044:Dietary Proteins / Q000627:therapeutic use*; D005399:Fishes; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000145:classification* / Q000628:therapy; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D014508:Urea / Q000494:pharmacology
chemical_list: D004044:Dietary Proteins; D014508:Urea; D001120:Arginine