Cytogenetic and FISH investigations on tetrasomy 8 in ANLL.
Two patients with "de novo" ANLL and tetrasomy of chromosome 8 at diagnosis are described. A mosaic karyotype with coexistence of normal metaphases was found in both cases. Trisomy 8 was also present in one metaphase of the first patient. Fluorescent in situ hybridization with a centromeric probe from chromosome 8 was applied in the second case, confirming the presence of a minor population with trisomy 8 in interphase nuclei.
La Starza
R
R
Ematologia e Immunologia Clinica, Università degli Studi di Perugia, Policlinico Monteluce, Italy.
Crescenzi
B
B
Matteucci
C
C
Martelli
M F
MF
Mecucci
C
C
D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male