Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice.
In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo-inositol during acute and again during chronic relapsing EAE. The ratio of N-acetyl-aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.
Preece
N E
NE
Royal College of Surgeons Unit of Biophysics, Institute of Child Health, London, United Kingdom.
Amor
S
S
Baker
D
D
Gadian
D G
DG
O'Neill
J K
JK
Urenjak
J
J
D018354:Alphavirus Infections / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003401:Creatine / Q000378:metabolism; D018792:Encephalitis, Viral / Q000378:metabolism* / Q000821:virology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism*; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D012672:Semliki forest virus; D013116:Spinal Cord / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism*
D013654:Taurine; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine