title: Nicotine improves cognitive disturbance in senescence-accelerated mice.
abstract: Senescence-accelerated mice (SAM), a murine model of age-related deterioration in learning ability, were studied as to the acetylcholine (ACh) contents in the brain tissues and the effect of nicotine administration. We found that the ACh content of SAM-P/8 (accelerated senescence-prone) mice was lower than that of SAM-R/1 (accelerated senescence-resistant) mice in the midbrain thalamus and the hypothalamus. In addition, an IP administration of nicotine was found to improve learning ability of SAM-P/8 as shown by performance of a passive avoidance task. Nicotine may potentiate cognitive function in SAM-P/8.
authors.affiliation: Department of Geriatric Medicine, Tohoku University, School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Meguro
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: C
authors.initials: C
authors.lastname: Doi
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Ikarashi
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000375:Aging / Q000235:genetics / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002794:Choline / Q000378:metabolism; D003072:Cognition Disorders / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D009068:Movement / Q000187:drug effects; D009538:Nicotine / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D009538:Nicotine; D002794:Choline; D000109:Acetylcholine