title: Ancient origin of RNA editing in kinetoplastid protozoa.
abstract: A rooted phylogenetic tree of the kinetoplastid protozoa has been constructed that, together with a comparative analysis of editing of several genes, leads to the surprising conclusion that extensive or pan-editing with multiple overlapping guide RNAs is more ancient than 5'-editing. The mechanism of editing is still uncertain, but multiple ribonucleoprotein complexes have been identified that contain components of the enzymatic machinery.
authors.affiliation: Howard Hughes Medical Institute, Los Angeles.
authors.forename: L
authors.initials: L
authors.lastname: Simpson
authors.forename: D A
authors.initials: DA
authors.lastname: Maslov
mesh_terms: D000818:Animals; D001482:Base Composition; D005075:Biological Evolution; D018105:DNA, Kinetoplast / Q000235:genetics; D017125:Genes, Protozoan; D016830:Kinetoplastida / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D017393:RNA Editing / Q000235:genetics*; D017394:RNA, Guide, Kinetoplastida / Q000235:genetics* / Q000378:metabolism; D016053:RNA, Protozoan / Q000235:genetics* / Q000378:metabolism; D014500:Uracil Nucleotides / Q000378:metabolism
chemical_list: D018105:DNA, Kinetoplast; D016053:RNA, Protozoan; D014500:Uracil Nucleotides; D017394:RNA, Guide, Kinetoplastida