Indomethacin treatment in amphotericin B induced nephrogenic diabetes insipidus.
Nephrogenic diabetes insipidus (NDI) is a serious side effect of various drugs. Elevated renal prostaglandin E2 levels have been found in patients with lithium-induced NDI and have been implicated in the pathogenesis. We report the case of a patient who developed NDI following treatment with amphotericin B. Prostaglandin levels were elevated. Indomethacin had an antidiuretic effect and normalized prostaglandin levels.
Höhler
T
T
I. Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Germany.
Teuber
G
G
Wanitschke
R
R
Meyer zum Büschenfeld
K H
KH
D000666:Amphotericin B / Q000009:adverse effects*; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced* / Q000188:drug therapy; D004231:Diuresis / Q000187:drug effects; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000378:metabolism; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications; D008875:Middle Aged; D011453:Prostaglandins / Q000378:metabolism*; D014031:Tobramycin / Q000009:adverse effects; D014667:Vasopressins / Q000627:therapeutic use
D011453:Prostaglandins; D014667:Vasopressins; D000666:Amphotericin B; D014031:Tobramycin; D007213:Indomethacin