[Short-term administration of increasing doses of thyroxine has a different effect on serum lipids in male rats and in female rats].
The effects of short-term administration of thyroxine (T4) on serum levels of cholesterol, HDL-cholesterol and triacylglycerols were studied on young adult rats. T4 was injected in three different doses, i.e. 125, 250 and 500 micrograms for four days. The results show significant sexual differences. T4 caused a significant decrease in HDL-cholesterol levels in both sexes. The concentration of cholesterol and triacylglycerol decreased only in males, namely after injections of the highest dose of T4. In females the T4 injections caused no effect in the investigated parameters. It is concluded, that also in short-term applications of hormones, the sex may significantly change the results. Presented results support the latest views on specific interrelationship between thyroid hormone and HDL in comparison with other types of LP. (Tab. 2, Ref. 16.).
Pullmann
R
R
Oddelenie klinickej biochémie MFN, Martin, Slovakia.
Sámel
M
M
Lazár
J
J
Dobias
J
J
Bukovská
E
E
Kosková
E
E
D000818:Animals; D005260:Female; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013974:Thyroxine / Q000008:administration & dosage*
D008055:Lipids; D013974:Thyroxine
Krátkodobá aplikácia stúpajúcich dávok tyroxínu má rozdielny úcinok na lipidy séra u samcov a samíc potkanov.