Photoactive terthiophenes: the influence of serum on anti-HIV (human immunodeficiency virus) activities.
A number of carboxylic acid derivatives of the photoactive terthiophene, alpha-terthienyl, were found to possess impressive UVA-dependent activity against the human immunodeficiency virus, HIV-1; but only when assayed in the absence of serum, indicating that the latter contained interfering components. Good antiviral activity required a high rate of singlet oxygen production, in accordance with previous observations on thiophenes.
Hudson
J B
JB
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Marles
R J
RJ
Soucy-Breau
C
C
Harris
L
L
Arnason
J T
JT
D000998:Antiviral Agents / Q000494:pharmacology*; D001769:Blood; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010100:Oxygen; D017319:Photosensitizing Agents / Q000494:pharmacology*; D026082:Singlet Oxygen; D013876:Thiophenes / Q000494:pharmacology*
D000998:Antiviral Agents; D017319:Photosensitizing Agents; D013876:Thiophenes; C019101:alpha-terthienyl; D026082:Singlet Oxygen; D010100:Oxygen