High risk genotypes for celiac disease.
It is known that celiac disease is strongly associated with an HLA class II component and that most patients carry the dimer DQA1*0501, DQB1*0201. We show in this study that the risk for a carrier of this heterodimer is independent from the number of possible heterodimers, from whether DQA1*0501 and DQB1*0201 are in cis or trans position and from the number of DQA1*0501 (one or two) but strongly depends on the number of DQB1*0201. In the Tunisian population we studied, the risk of developing celiac disease is estimated to be 6.8 times greater for those having a double dose of DQB1*0201 than for other dimer carriers. We replicated this result in published data of four other populations (Italy, Czekoslovakia, United Kingdom, Norway).
Clerget-Darpoux
F
F
Unité de Recherches d'Epidémiologie Génétique, Institut National de la Santé et de la Recherche Médicale U155, Paris, France.
Bouguerra
F
F
Kastally
R
R
Semana
G
G
Babron
M C
MC
Debbabi
A
A
Bennaceur
B
B
Eliaou
J F
JF
D000293:Adolescent; D000483:Alleles; D002446:Celiac Disease / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors
D006683:HLA-DQ Antigens