Influence of ranitidine on the hypoglycaemic activity of glibenclamide and tolbutamide in rabbits.
The influence of ranitidine on the hypoglycaemic activity of glibenclamide and tolbutamide was studied in rabbits. Ranitidine treatment (15 mg/kg, po, twice daily for one week) enhanced the hypoglycaemic activity of glibenclamide (40 micrograms/kg, po) while it has not altered either the hypoglycaemic activity or pharmacokinetics of tolbutamide (40 mg/kg, po) in rabbits.
Krishnaiah
Y S
YS
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam.
Satyanarayana
S
S
Visweswaram
D
D
D000818:Animals; D004347:Drug Interactions; D005905:Glyburide / Q000493:pharmacokinetics* / Q000494:pharmacology; D007003:Hypoglycemia / Q000139:chemically induced*; D011817:Rabbits; D011899:Ranitidine / Q000494:pharmacology*; D014044:Tolbutamide / Q000493:pharmacokinetics* / Q000494:pharmacology
D011899:Ranitidine; D014044:Tolbutamide; D005905:Glyburide