6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells.
6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference in p53 and c-myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.
Grdisa
M
M
Department of Molecular Medicine, Ruder Bosković Institute, Zagreb, Croatia.
Kralj
M
M
Eckert-Maksić
M
M
Maksić
Z B
ZB
Pavelić
K
K
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
C092414:6-amino-6-deoxyascorbic acid; D000970:Antineoplastic Agents; D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53; D004247:DNA; D001205:Ascorbic Acid