Peripheral T-cell lymphoma involving subcutaneous tissue.
The peripheral T-cell lymphomas, presumably derived from various immunocompetent peripheral T-cell system components, form a heterogeneous group of non-Hodgkin's lymphomas. We describe two patients with peripheral T-cell lymphoma primarily involving subcutaneous tissue. They presented with multiple subcutaneous nodules. Skin biopsy specimens in both patients demonstrated a lobular subcutaneous infiltrate. The infiltrate consisted of small and medium-sized atypical lymphoid cells. Both patients had a protracted clinical course before they were diagnosed as having malignant lymphoma. We detected latent Epstein-Barr virus infection in the skin lesions of case 2. Latent Epstein-Barr virus infection might be related to the development of this variant of peripheral T-cell lymphoma.
Cho
K H
KH
Department of Dermatology, Seoul National University College of Medicine, Korea.
Oh
J K
JK
Kim
C W
CW
Heo
D S
DS
Kim
S T
ST
D000328:Adult; D005260:Female; D006566:Herpesviridae Infections / Q000175:diagnosis; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology* / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral / Q000473:pathology* / Q000821:virology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*; D014412:Tumor Virus Infections / Q000175:diagnosis