Establishment of multiple leukemia cell lines with diverse myeloid and/or megakaryoblastoid characteristics from a single Ph1 positive chronic myelogenous leukemia blood sample.
Seven cell lines, MOLM-6, -7, -8, -9, -10, -11 and -12, were established from a single blood sample from a patient with chronic myelogenous leukemia (CML) in blastic phase having the Ph1 chromosome abnormality. Based on immunophenotyping, two of these seven cell lines, MOLM-7 and -11, represented the megakaryoblastoid lineage, and the other five cell lines represented two different maturation stages of the myeloid lineage.
Tsuji-Takayama
K
K
Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc.
Kamiya
T
T
Nakamura
S
S
Matsuo
Y
Y
Adachi
T
T
Tsubota
T
T
Imanishi
J
J
Minowada
J
J
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002460:Cell Line; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D014407:Tumor Cells, Cultured