Effect of phenazone (antipyrine) on the prostanoid formation in human umbilical arteries perfused in vitro.
The influence of phenazone on the production of prostacyclin and thromboxane in human umbilical arteries was investigated by in vitro perfusion. With perfusate concentrations ranging from 10(-7) to 10(-4) M a decrease in the formation of both prostanoids was observed. The inhibitory effect of phenazone on prostanoid formation was found to be equal to that of indomethacin.
Haugen
G
G
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
Stray-Pedersen
S
S
Bjøro
K
K
D000983:Antipyrine / Q000494:pharmacology* / Q000627:therapeutic use; D001095:Arachidonic Acids / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy; D011460:Prostaglandins F / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis; D014469:Umbilical Arteries / Q000187:drug effects* / Q000378:metabolism
D001095:Arachidonic Acids; D011460:Prostaglandins F; D013929:Thromboxane B2; D000983:Antipyrine; C100006:prostaglandin F1; D007213:Indomethacin