title: Percutaneous computed tomography-guided ethanol injection in aldosterone-producing adrenocortical adenoma.
abstract: The feasibility, safety and effectiveness of percutaneous computed tomography-guided ethanol injection (PEI-CT) was investigated in a patient affected by aldosterone-producing adenoma (APA). A 42-year-old male patient with typical features of hyperaldosteronism presented a solitary left adrenal adenoma measuring 2 cm, with a normal contralateral gland, evidenced by both CT scan and adrenal [75Se-19]-nor-cholesterol scintigraphy. After normalization of potassium plasma levels, 4 ml of sterile 95% ethanol with 0.5 ml of 80% iothalamate sodium was injected. The procedure was completed in about 30 min. No severe pain or local complication was noted. Five hours after PEI, a fourfold and a twofold increase in aldosterone and cortisol plasma levels were observed, respectively. After 11 days on a normal sodium and potassium diet, normal potassium plasma levels and reduced aldosterone plasma levels were present, with reappearance of an aldosterone postural response. Plasma renin activity and aldosterone plasma levels normalized 1 month later, with reappearance also of a plasma renin activity postural response and maintenance of normal potassium plasma levels even on a high sodium and normal potassium diet. The patient has remained hypertensive, although lower antihypertensive drug dosages have been employed. After 17 months, normal biochemical, hormonal and morphological findings were still present. Thus, we suggest PEI-CT as a further alternative approach to surgery in the management of carefully selected patients with APA.
authors.affiliation: Chair of Endocrinology, CNR Center of Experimental Endocrinology and Oncology, Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Savastano
authors.forename: A P
authors.initials: AP
authors.lastname: Tommaselli
authors.forename: R
authors.initials: R
authors.lastname: Valentino
authors.forename: V
authors.initials: V
authors.lastname: Iaccarino
authors.forename: L
authors.initials: L
authors.lastname: Tauchmanova
authors.forename: A
authors.initials: A
authors.lastname: Luciano
authors.forename: M
authors.initials: M
authors.lastname: Gigante
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D018246:Adrenocortical Adenoma / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D000431:Ethanol; D000450:Aldosterone