title: Superoxide dismutase and glutathione peroxidase activities are increased by enalapril and captopril in mouse liver.
abstract: We have characterized the effect of angiotensin converting enzyme (ACE) inhibitors on the activity of CuZn-superoxide dismutase (CuZn-SOD), Mn-superoxide dismutase (Mn-SOD), catalase, and selenium-dependent glutathione peroxidase (Se-GPx). CF1 mice (4-month-old females) were administered water containing enalapril (20 mg/l) or captopril (50 mg/l), during 4 to 11 weeks. After 11 weeks, enalapril treatment caused an increase in the activity of CuZn-SOD, Mn-SOD and Se-GPx, from 19 +/- 4 to 46 +/- 7, 2.1 +/- 0.2 to 3.8 +/- 0.2 units/mg protein and 27 +/- 3 to 54 +/- 3 milliunits/mg protein, respectively. After 11 weeks, captopril treatment increased the activities (P < 0.05) of CuZn-SOD, MnSOD and Se-GPx to 35 +/- 4, 2.9 +/- 0.2 units/mg protein, and 38 +/- 2 milliunits/mg protein, respectively. Catalase activity was not affected by the treatments. These results suggest that ACE inhibitors may protect cell components from oxidative damage by increasing the enzymatic antioxidant defenses.
authors.affiliation: Institute of Nephrology, Jewish Hospital, Buenos Aires, Argentina.
authors.forename: E M
authors.initials: EM
authors.lastname: de Cavanagh
authors.forename: F
authors.initials: F
authors.lastname: Inserra
authors.forename: L
authors.initials: L
authors.lastname: Ferder
authors.forename: L
authors.initials: L
authors.lastname: Romano
authors.forename: L
authors.initials: L
authors.lastname: Ercole
authors.forename: C G
authors.initials: CG
authors.lastname: Fraga
mesh_terms: D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D004656:Enalapril; D002216:Captopril; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase