title: [Anticardiolipin antibodies in parenteral drug addicts: relationship with HIV].
abstract: The IgG isotype of anticardiolipin antibodies (aCL) and its possible relationship with the immunodeficiency virus (HIV) were studied in 65 parenteral drug addicts (PDA). Thirty-seven patients were infected in the present study. Nineteen (51%) fulfilled diagnostic criteria of AIDS. Thirty-two of these 37 HIV-positive patients (86%) were IgG-aCL positive. Fourteen (50%) of the 28 HIV-negative patients were IgG-aCL positive. Our study reveals a lack of correlation between aCL and thrombocytopenia. None of the patients had thromboembolic complications. In AIDS patients no relationship was found between IgG-aCL levels and the presence of Pneumocystis carinii, other infections by opportunist microorganism, and clinical deterioration. Highly increased levels of IgG-aCL (> 80 GPL) were observed in three patients with AIDS and infectious endocarditis. In conclusion, given the non-specificity of aCL en PDA, it is our opinion that its measurement is of little help in daily clinical praxis.
authors.affiliation: Sección de Reumatología, Hospital Universitario Reina Sofía, Córdoba.
authors.forename: J
authors.initials: J
authors.lastname: González Domínguez
authors.forename: C
authors.initials: C
authors.lastname: Ortega
authors.forename: R
authors.initials: R
authors.lastname: Jurado
authors.forename: M L
authors.initials: ML
authors.lastname: Muñoz
authors.forename: J
authors.initials: J
authors.lastname: Torre-Cisneros
authors.forename: J M
authors.initials: JM
authors.lastname: Kindelan
authors.forename: M
authors.initials: M
authors.lastname: Santamaría
mesh_terms: D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders / Q000150:complications / Q000276:immunology*
chemical_list: D017153:Antibodies, Anticardiolipin
vernacular_title: Anticuerpos anticardiolipina en adictos a drogas por vía parenteral: relación con el virus de inmunodeficiencia humana.