title: Response of canine mast cell tumors to treatment with oral prednisone.
abstract: Twenty-five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy.
authors.affiliation: Department of Veterinary Medicine and Surgery, University of Missouri, Columbia 65211.
authors.forename: D L
authors.initials: DL
authors.lastname: McCaw
authors.forename: M A
authors.initials: MA
authors.lastname: Miller
authors.forename: G K
authors.initials: GK
authors.lastname: Ogilvie
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow
authors.forename: W G
authors.initials: WG
authors.lastname: Brewer
authors.forename: M K
authors.initials: MK
authors.lastname: Klein
authors.forename: F W
authors.initials: FW
authors.lastname: Bell
authors.forename: S K
authors.initials: SK
authors.lastname: Anderson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D012515:Mast-Cell Sarcoma / Q000188:drug therapy / Q000662:veterinary*; D009367:Neoplasm Staging / Q000662:veterinary; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D011241:Prednisone