title: Individual differences in sugar intake predict the locomotor response to acute and repeated amphetamine administration.
abstract: Rats exhibit profound individual differences in their propensity to ingest sugar and in their locomotor response to AMP. Intrinsic variation in the responsiveness of mesolimbic dopamine mechanisms has been suggested to account for these individual differences. In light of this overlap, it might be expected that individual differences in one behavior would predict individual differences in the other. The present study determined whether individual differences in sugar intake would predict individual differences in the locomotor response to AMP. Male Wistar rats were divided into low and high feeders based on a median split of their sugar intake in response to saline administration and were subsequently tested for their locomotor response to either 1.0 or 1.75 mg/kg AMP in experiment 1. High sugar feeders exhibited significantly more locomotion than low sugar feeders in response to 1.75 mg/kg AMP. This difference was observed immediately after injection and continued for approximately 90 min. There was no difference between the two groups in their locomotor response to 1.0 mg/kg AMP. In experiment 2, rats receiving 1.0 mg/kg AMP in experiment 1 were tested for the development of behavioral sensitization with repeated AMP administrations. Rats were administered 1.0 mg/kg AMP across 5 test days, interspersed with days in which they received AMP treatment in their home cages to minimize conditioning effects. High sugar feeders exhibited greater behavioral sensitization than low sugar feeders with repeated AMP administration. Starting on test day 3, high sugar feeders exhibited significantly greater AMP-induced locomotor activity than low sugar feeders.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Psychology Department, University of Toronto, Ontario, Canada.
authors.forename: T L
authors.initials: TL
authors.lastname: Sills
authors.forename: F J
authors.initials: FJ
authors.lastname: Vaccarino
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002241:Carbohydrates; D005518:Food Preferences / Q000523:psychology*; D007206:Individuality; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical
chemical_list: D002241:Carbohydrates; D000661:Amphetamine