Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization.
A family of human genes encoding basic-leucine zipper (bZIP) transcription factors, p45-NF-E2, Nrf1 and Nrf2, have been isolated independently. Whereas the encoded proteins of the three genes share highly conserved regions distinct from other bZIP families such as Jun or Fos, remaining regions diverged considerably from each other. Chromosomal localization by fluorescence in situ hybridization demonstrates that these genes are non-syntenic. p45-NF-E2 mapped to chromosome 12q13.1-13.3, whereas Nrf1 and 2 mapped to 17q21.3 and 2q31, respectively. However, these three genes were probably derived from a single ancestor by chromosomal duplication as other genes that also map in these regions are related to one another.
Chan
J Y
JY
Department of Laboratory Medicine, University of California, San Francisco 94143-0724.
Cheung
M C
MC
Moi
P
P
Chan
K
K
Kan
Y W
YW
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D002889:Chromosomes, Human, Pair 2; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics; D050981:Erythroid-Specific DNA-Binding Factors; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016350:Leucine Zippers / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D050983:NF-E2 Transcription Factor; D050984:NF-E2 Transcription Factor, p45 Subunit; D051267:NF-E2-Related Factor 2; D051266:Nuclear Respiratory Factor 1; D051264:Nuclear Respiratory Factors; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D050983:NF-E2 Transcription Factor; D050984:NF-E2 Transcription Factor, p45 Subunit; D051267:NF-E2-Related Factor 2; C494692:NFE2 protein, human; C495635:NFE2L2 protein, human; C495633:NRF1 protein, human; D051266:Nuclear Respiratory Factor 1; D051264:Nuclear Respiratory Factors; D015534:Trans-Activators; D014157:Transcription Factors