title: [Cholestatic viral hepatitis A in adults. Clinical, biological and histopathological study of 9 cases].
abstract: OBJECTIVE
  We report here 9 cases of acute viral hepatitis A leading to hospitalization between June 1989 and October 1992. The main feature was a marked and protracted cholestasis.
  
  
  RESULTS
  Jaundice lasted an average of 77 +/- 39 days (range: 30-120) and total serum bilirubin concentrations were 265 +/- 184 mumol/L (range: 51-560). IgM anti-HAV was present in the serum for 6.3 +/- 5.5 months (median: 4, range: 2-19). Histopathological examination of the liver was performed in 6 patients and most showed intralobular cholestasis and portal tract inflammation associated with dystrophy and paucity of bile ducts. Acute renal failure was noted in one patient. In three patients, whose pruritus was not relieved by cholestyramine, plasma exchange was an effective therapy.
  
  
  CONCLUSIONS
  These case reports confirm the severity of viral hepatitis A in adults and emphasize the importance of vaccination.
authors.affiliation: Service d'Hépato-Gastroentérologie, Groupe Hospitalier de la Pitié-Salpêtrière, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Corpechot
authors.forename: J F
authors.initials: JF
authors.lastname: Cadranel
authors.forename: C
authors.initials: C
authors.lastname: Hoang
authors.forename: U
authors.initials: U
authors.lastname: Assogba
authors.forename: J L
authors.initials: JL
authors.lastname: Beaumont
authors.forename: O
authors.initials: O
authors.lastname: Rogeaux
authors.forename: F
authors.initials: F
authors.lastname: Lunel
authors.forename: P
authors.initials: P
authors.lastname: Opolon
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D001647:Bile Acids and Salts / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001774:Blood Chemical Analysis; D002779:Cholestasis / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000628:therapy; D005260:Female; D006506:Hepatitis A / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange / Q000379:methods*
chemical_list: D001647:Bile Acids and Salts; D001663:Bilirubin
vernacular_title: Hépatite virale A cholestatique de l'adulte. Etude clinique, biologique et histopathologique de 9 cas.