[A case of MRSA sepsis treated by the sequential combination therapy netilmycin and minocycline].
A sixteen year old female was feverish from June 12, 1993. Methicillin-resistant Staphylococcus aureus was isolated from the blood, the diagnosis of MRSA sepsis was established. Vancomycin (2 g/day) was administered for eighteen days, but MRSA was not eradicated in the blood culture. Then she was administered a combination therapy of arbekacin (200 mg/day) and imipenem/cilastain (1 g/day) for seven days, but MRSA in the blood was cultured continuously. The sequential combination therapy of netilmycin (200 mg/day) and minocycline (200 mg/day) was started, MRSA was eradicated from the blood culture after four days. The sequential combination therapy netilmycin and minocycline was seemed to be effective for MRSA infection.
Maesaki
S
S
Sasebo General Hospital.
Mashimoto
H
H
Araki
J
J
Asai
S
S
Sawatari
K
K
D000293:Adolescent; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D004359:Drug Therapy, Combination / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D016106:Methicillin Resistance; D008911:Minocycline / Q000008:administration & dosage / Q000494:pharmacology; D009428:Netilmicin / Q000008:administration & dosage / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*
D009428:Netilmicin; D008911:Minocycline