Successful long-term pancreatic islet cell xenotransplantation and functional tolerance in NOD mice.
These findings raise a high degree of optimism concerning the potential application of this modality in higher animals. Studies are currently in process in our laboratory to apply this immunosuppressive regimen to higher animals using xenogeneic pig islets in a preclinical model that would provide the basis for future clinical trials.
Ljung
T
T
East Carolina University School of Medicine/University Medical Center, Greenville, NC 27858.
Pittman
K
K
Thomas
F T
FT
D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D002478:Cells, Cultured; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000628:therapy*; D006146:Guanidines / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000166:cytology; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000502:physiology*; D051379:Mice; D016688:Mice, Inbred NOD; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology / Q000502:physiology*
D000961:Antilymphocyte Serum; D001786:Blood Glucose; D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus