Hepatic functional reserve in patients with obstructive jaundice: an assessment by the redox tolerance test.
OBJECTIVE
Hepatic mitochondrial response to oral glucose load (redox tolerance test) was evaluated as an indicator of hepatic functional reserve of patients with obstructive jaundice.


METHODS
The redox tolerance test was performed in 29 patients with obstructive jaundice before percutaneous transhepatic biliary drainage and 2 weeks after the procedure.


RESULTS
The redox tolerance index (RTI) before drainage was not related to conventional parameters other than albumin, but was significantly associated with bilirubin half-life (P < 0.01). Of 19 patients with an RTI > or = 0.5 before drainage, all maintained similar values after drainage and experienced satisfactory clinical courses, even after major surgery. Of 10 patients with an RTI < 0.5 before drainage, 5 showed improvement and 5 deteriorated after drainage. Four of the latter 5 died within 60 days after drainage. The hospital mortality was significantly greater in patients with initial RTI < 0.5 than in patients with RTI > or = 0.5 (P < 0.01).


CONCLUSIONS
The redox tolerance test is useful for evaluating hepatic functional reserve and prognosis in patients with obstructive jaundice.
Tsubono
T
T
Department of Surgery, Niigata University School of Medicine, Japan.
Tsukada
K
K
Hatakeyama
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000378:metabolism* / Q000601:surgery; D005260:Female; D005951:Glucose Tolerance Test; D017052:Hospital Mortality; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D011379:Prognosis; D012720:Severity of Illness Index; D013105:Sphincterotomy, Transduodenal / Q000401:mortality
D001663:Bilirubin