Prevention of mercuric chloride induced histopathological changes in the small intestine of mice with LIV-52.
Mercuric chloride was administered in drinking water to mice at 1 mM and 5 mM for 100 and 30 days respectively. Lower concentration caused mild pathological changes in the small intestine while higher concentration caused severe pathological changes. Pathological symptoms were less pronounced when Liv52 was administered along with 5 mM mercuric chloric and Hg-induced changes were totally absent when drug was used along with 1 mM HgCl2 solution. After Hg-exposure at both concentrations mice were allowed to recover naturally or with drug (Post-therapy). Again, use of drug appeared useful. At least under laboratory conditions this herbal drug seems to reduce Hg-induced pathological changes in small intestine of mice.
Johnson
V
V
Cell Biology Unit, School of Studies in Zoology, Vikram University, Ujjain, India.
Rathore
H S
HS
D000818:Animals; D004338:Drug Combinations; D007410:Intestinal Diseases / Q000139:chemically induced / Q000517:prevention & control; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008627:Mercuric Chloride / Q000506:poisoning*; D051379:Mice; D009336:Necrosis; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D011041:Poisoning / Q000188:drug therapy
D004338:Drug Combinations; D010936:Plant Extracts; D008627:Mercuric Chloride; C002614:Liv 52