[Diagnostic value of oligoclonal band detection in cerebrospinal fluid using PhastSystem device].
The study confirming the presence of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing (IEF) with PhastSystem equipment was carried out in 68 patients with clinically definite MS, in 23 with clinically probable MS and in 23 with other neurological diseases. Other indicators intrathecal synthesis of IgG were olso marked. According to the results it was confirmed that the most sensitive method of detection of intrathecal synthesis of immunoglobulins is finding of the oligoclonal IgG. Using the PhastSystem evidently shorties the diagnostic process. The sensivity of the method equals that of MRI and both have similar clinical value.
Zaborski
J
J
Klinika Chorób Naczyniowych Układu Nerwowego Instytutu Psychiatrii i Neurologii, Warszawie.
Fiszer
U
U
Kruszewska
J
J
Korlak
J
J
Poniatowska
R
R
Członkowska
A
A
D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000503:physiopathology; D004586:Electrophoresis / Q000379:methods*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000503:physiopathology; D015203:Reproducibility of Results
D007074:Immunoglobulin G
Wartość diagnostyczna wykrywania pasm oligoklonalnych w płynie mózgowo-rdzeniowym z zastosowaniem aparatu PhastSystem.