title: Occupational exposure to radiation induces an adaptive response in human lymphocytes.
abstract: The in vitro pretreatment of phytohaemagglutinin stimulated human lymphocytes with tritiated thymidine or with low doses of X-rays induces a response that makes these cells less susceptible to further genetic damage induced by subsequent high doses of radiation. This phenomenon has been called 'Adaptive Response' because it is similar to the one described in E. coli. In the present study, we describe that lymphocytes irradiated in vitro at 2 Gy, from individuals occupationally exposed to X and gamma rays, show lower frequencies of dicentrics than those from non-occupationally exposed individuals irradiated in the same conditions. Our results could indicate that an adaptive response can also be induced in lymphocytes in vivo by very low occupational doses of radiation, and that for biological dosimetry purposes it is necessary to know the individual's history of exposure to mutagens.
authors.affiliation: Dpt. Biologia Animal, Biologia Vegetal i Ecologia., Facultat de Ciencies, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Barquinero
authors.forename: L
authors.initials: L
authors.lastname: Barrios
authors.forename: M R
authors.initials: MR
authors.lastname: Caballín
authors.forename: R
authors.initials: R
authors.lastname: Miró
authors.forename: M
authors.initials: M
authors.lastname: Ribas
authors.forename: A
authors.initials: A
authors.lastname: Subias
authors.forename: J
authors.initials: J
authors.lastname: Egozcue
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure