[Cyclic neutropenia and treatment with granulocyte colony-stimulating factor (G-CSF)].
A patient with familial cyclic neutropenia (CN) is presented. In a son of a mother with known CN, periodic neutropenia was demonstrated a few months after birth. At 18 years of age, the boy had recurrent episodes of cervical lymphadenopathy, complicated by an abscess. Periodic treatment with granulocyte-colony stimulating factor (G-CSF) was initiated, and since then, he hardly had any symptoms and clinically showed substantial improvement. Based on in-vitro colony assays of patients with CN, it is nowadays suggested that a disturbance in growth factor receptor binding or post-receptor signal transduction is the cause of this rare benign haematological disorder.
Anninga
J K
JK
Academisch Medisch Centrum, Emma Kinderziekenhuis/het Kinder-AMC, Amsterdam.
Weening
R S
RS
D000293:Adolescent; D004804:Eosinophils / Q000187:drug effects; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006098:Granulocytes / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009000:Monocytes / Q000187:drug effects; D009503:Neutropenia / Q000188:drug therapy* / Q000503:physiopathology; D010507:Periodicity
D016178:Granulocyte-Macrophage Colony-Stimulating Factor
Cyclische neutropenie en behandeling met granulocyt-kolonie-stimulerende factor (G-CSF).