title: Benzimidazo[1,2-c]quinazolines: a new class of antitumor compounds.
abstract: A series of substituted benzimidazo[1,2-c]quinazolines have been synthesized. This class of compound has been designed by structural comparison with other intercalator patterns. The determination of in vitro activities has shown high inhibitory values.
authors.affiliation: Laboratorios Knoll S.A., Madrid, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: Braña
authors.forename: J M
authors.initials: JM
authors.lastname: Castellano
authors.forename: G
authors.initials: G
authors.lastname: Keilhauer
authors.forename: A
authors.initials: A
authors.lastname: Machuca
authors.forename: Y
authors.initials: Y
authors.lastname: Martín
authors.forename: C
authors.initials: C
authors.lastname: Redondo
authors.forename: E
authors.initials: E
authors.lastname: Schlick
authors.forename: N
authors.initials: N
authors.lastname: Walker
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology; D018360:Crystallography, X-Ray; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007364:Intercalating Agents; D007939:Leukemia L1210 / Q000473:pathology; D008968:Molecular Conformation; D015394:Molecular Structure; D012516:Osteosarcoma / Q000473:pathology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
chemical_list: C092455:6-(2-(piperidino)ethylamino)benzimidazo(1,2-c)quinazoline; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D007364:Intercalating Agents; D011799:Quinazolines; D004247:DNA