title: [The effect of SolcoTrichovac on the vaginal microflora of patients with a papillomavirus infection associated with a cervical intraepithelial neoplasm].
abstract: The microbiological study of vaginal secretions of 39 female patients of reproductive age (20-30 years) with papilloma virus infection associated with cervical intraepithelial neoplasia (CIN) was carried out. Of these patients, 28 with papilloma virus infection associated with CINI-II made up group I and II having this infection associated with CINII made up group 2. Dysbiotic disturbances in vaginal bacterial flora, found in these patients, were manifested by a decrease in the isolation rate and number of the lacto- and bifidobacteria simultaneously with the excessive growth of opportunistic bacteria. The results of the oral administration of Solco-Trichovac are indicative of the effectiveness of this preparation, which was confirmed by the data of clinical and bacteriological studies. Together with an increase in the isolation rate of lacto- and bifidobacteria, the level of the contamination of the cervicovaginal niche with opportunistic and pathogenic bacterial strains decreased. The results thus obtained make it possible to recommend Solco-Trichovac for the complex treatment of with papilloma virus infection associated with CIN.
authors.forename: V M
authors.initials: VM
authors.lastname: Korshunov
authors.forename: L I
authors.initials: LI
authors.lastname: Kafarskaia
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Bagirova
authors.forename: G N
authors.initials: GN
authors.lastname: Minkina
authors.forename: I B
authors.initials: IB
authors.lastname: Manukhin
authors.forename: W
authors.initials: W
authors.lastname: Bossart
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000382:microbiology; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007778:Lactobacillus; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000188:drug therapy* / Q000821:virology; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000821:virology; D002577:Uterine Cervical Diseases / Q000188:drug therapy / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000821:virology; D014621:Vagina / Q000187:drug effects* / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000188:drug therapy* / Q000821:virology
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; C039045:SolcoTrichovac
vernacular_title: Izuchenie vliianiia "Solkotrikhovaka" na vaginal'nuiu mikrofloru u bol'nykh s papillomavirusnoĭ infektsieĭ v assotsiatsii s tservikal'noĭ intraépitelial'noĭ neoplazieĭ.