title: Basal plasma concentration of tissue plasminogen activator (t-PA) and the adaption to strenuous exercise in familial hypercholesterolaemia (FH).
abstract: Epidemiological studies have provided evidence that attenuated fibrinolytic activity and increased antigen levels of plasminogen activator are risk factors for coronary heart disease (CHD). In a comparative study, tissue plasminogen activator (t-PA) antigen and activity concentrations were examined in plasma from familial hypercholesterolaemia (FH) patients without manifest CHD (n = 14) and in age- and sex-matched normolipaemic controls (NLC) at rest and after the same bicycle exercise. The FH patients had higher systolic and diastolic blood pressure than their controls. The plasma level of t-PA antigen was higher in FH patients than in NLC under basal conditions (7.3 +/- 3.1 ng/ml vs 4.8 +/- 2.2 ng/ml, P = 0.022), whereas no difference was found in t-PA activity. Bicycle exercise induced a marked increase in t-PA antigen (P < 0.001 for both groups) which did not differ between groups. A more prominent rise in t-PA activity was observed among the FH patients during the exercise (1.71 +/- 0.99 vs 0.85 +/- 0.89 IU/ml, P = 0.24). Neither the basal level of thrombin-antithrombin III complex (TAT) nor the significant increase (P < 0.001 for both groups) induced by exercise differed between groups. A high t-PA antigen level may precede clinical manifestations of cardiovascular disease in patients with familial hypercholesterolaemia.
authors.affiliation: Department of Medicine, University of Tromsø, Norway.
authors.forename: J B
authors.initials: JB
authors.lastname: Hansen
authors.forename: B
authors.initials: B
authors.lastname: Svensson
authors.forename: C L
authors.initials: CL
authors.lastname: Zhang
authors.forename: V
authors.initials: V
authors.lastname: Lyngmo
authors.forename: A
authors.initials: A
authors.lastname: Nordøy
mesh_terms: D000222:Adaptation, Physiological; D000990:Antithrombin III / Q000378:metabolism; D001794:Blood Pressure; D003327:Coronary Disease / Q000209:etiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D010959:Tissue Plasminogen Activator