title: Functional and antiischemic effects of luteolin-7-glucoside in isolated rabbit hearts.
abstract: 1. The functional effects of the flavonoid luteolin-7-glucoside (LUT) were investigated in Langendorff-rabbit hearts perfused at constant pressure. Repetitive myocardial ischemia was induced by coronary artery ligature and quantified from NADH-fluorescence photography. 2. LUT significantly enhanced left ventricular pressure and the global and relative coronary flow (= global coronary flow/pressure-rate product). 3. LUT significantly diminished epicardial NADH-fluorescence area and intensity. 4. LUT is an inodilator possessing cardioprotective properties. These might be related to an improvement of myocardial perfusion and/or to free radical scavenging properties.
authors.affiliation: Institut für Pharmakologie, Universität Köln, Germany.
authors.forename: A F
authors.initials: AF
authors.lastname: Rump
authors.forename: M
authors.initials: M
authors.lastname: Schüssler
authors.forename: D
authors.initials: D
authors.lastname: Acar
authors.forename: A
authors.initials: A
authors.lastname: Cordes
authors.forename: M
authors.initials: M
authors.lastname: Theisohn
authors.forename: R
authors.initials: R
authors.lastname: Rösen
authors.forename: W
authors.initials: W
authors.lastname: Klaus
authors.forename: U
authors.initials: U
authors.lastname: Fricke
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D005453:Fluorescence; D016166:Free Radical Scavengers; D005960:Glucosides / Q000494:pharmacology*; D066298:In Vitro Techniques; D047311:Luteolin; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology*; D009243:NAD / Q000378:metabolism; D010477:Perfusion; D010726:Phosphodiesterase Inhibitors; D011817:Rabbits; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D005419:Flavonoids; D016166:Free Radical Scavengers; D005960:Glucosides; D010726:Phosphodiesterase Inhibitors; D009243:NAD; C066408:luteolin-7-glucoside; D047311:Luteolin