title: Effect of albendazole on the larvae and eggs of Necator americanus in golden hamster.
abstract: When golden hamsters infected with adult Necator americanus were treated ig with albendazole(Alb) 75 or 150 mg/kg, the efficacy rates were 83.8% and 100%, respectively. Three days before treatment, the mean numbers of larvae recorded from the incubation of feces from 2 treated groups were 29,716 +/- 3,299 and 28,256 +/- 118 per gram of feces, while in the control group, it was 8,828 +/- 2,659. Within 3 days after treatment, no larva was detected in the 2 treated groups, but in the control group the mean larva number was 9,066 +/- 7,416. Furthermore, in 2 treated groups none or only a few degenerated eggs could be found using saturated saline solution method. when infected golden hamsters were treated ig with Alb at a single dose of 150 or 300 mg/kg on day 3, 7 or 14 after infection with the third stage larvae, the egg positive rates in the feces were 0-9.1%, while the worm reduction rates were 96.8-100%.
authors.affiliation: Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine (WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis), Shanghai.
authors.forename: H
authors.initials: H
authors.lastname: Ren
authors.forename: H
authors.initials: H
authors.lastname: Qiang
authors.forename: Q
authors.initials: Q
authors.lastname: Jin
authors.forename: L
authors.initials: L
authors.lastname: Zhao
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Xiao
mesh_terms: D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D006224:Cricetinae; D005260:Female; D007814:Larva / Q000187:drug effects; D008297:Male; D008647:Mesocricetus; D017221:Necator americanus / Q000187:drug effects*; D009332:Necatoriasis / Q000188:drug therapy*; D010063:Ovum / Q000187:drug effects
chemical_list: D015766:Albendazole