The effect of ethanol intake on the development of hepatocellular carcinoma in HBsAg carriers.
To study the effect of alcohol intake on the latency period for the development of hepatocellular carcinoma in a country where this tumor occurs earlier in life than in Southeast of Asia, Europe or North America, 83 male patients with hepatocellular carcinoma aged over 30 years, in which the HBsAg status and ethanol intake were prospectively investigated, were analyzed with respect to age at the time of diagnosis. Only male patients were used because in Vitória, State of Espírito Santo, the age at the time of diagnosis of hepatocellular carcinoma in females is significantly lower than in males. Only patients aged over 30 years were used because the tumor occurs in young people and children, in which habitual alcohol intake is not common. Forty-six patients with hepatocellular carcinoma HBsAg positive and 36 HBsAg negative were separated in alcohol abusers (daily ingestion above 80 g for a period of 10 years or more) or nonalcoholics. The occurrence of associated liver cirrhosis was determined for each group. For comparison of the average age of the four groups the Student t test and the Kruskall-Wallis test for two groups were used. The results showed that the average age of patients with hepatocellular carcinoma HBsAg positive with habitual alcohol intake was significantly lower than those without drinking habit (44.3 +/- 9.7 and 52.3 +/- 15.7 years; P = 0.011 and 0.028 respectively for Student t test and Kruskall-Wallis test). The average age of patients with hepatocellular carcinoma HBsAg (-) with or without habitual ethanol intake showed no significative differences (56.7 +/- 11.3 and 57.3 +/- 12.4 P > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Pereira
F E
FE
Department of Pathology, Federal University of Espírito Santo, Vitória, Brazil.
Gonçalves
C S
CS
Zago
M da P
Mda P
D000328:Adult; D000367:Age Factors; D001938:Brazil; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000209:etiology*; D000431:Ethanol / Q000009:adverse effects*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic; D008113:Liver Neoplasms / Q000150:complications / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D006514:Hepatitis B Surface Antigens; D000431:Ethanol