title: [Implementing ambulatory prevention of thrombosis with low molecular weight heparin in plaster immobilization of the lower extremity].
abstract: Plaster cast immobilisation following trauma is a major risk factor for the development of deep vein thrombosis. In our controlled, randomized and prospective study in patients with minor injuries the incidence of deep vein thrombosis was 4.3% in conservatively treated outpatients with plaster cast immobilisation of the leg (n = 163 control group without prophylaxis). By application of low molecular weight heparin once daily the number of deep vein thrombosis in the prophylaxis group (n = 176) was reduced to 0% (p = 0.006). No severe side effects of low molecular weight heparin were observed. Subcutaneous injections were self-applicated by 89% of males and 72% of females. We conclude that thromboprophylaxis with low molecular weight heparin once daily is effective to reduce the risk of deep vein thrombosis in outpatients with plaster cast immobilisation of the leg.
authors.affiliation: Abteilung für Unfallchirurgie, Universitätsklinikums Essen.
authors.forename: H J
authors.initials: HJ
authors.lastname: Kock
authors.forename: K P
authors.initials: KP
authors.lastname: Schmit-Neuerburg
authors.forename: J
authors.initials: J
authors.lastname: Hanke
authors.forename: A
authors.initials: A
authors.lastname: Terwort
authors.forename: G
authors.initials: G
authors.lastname: Rudofsky
authors.forename: H
authors.initials: H
authors.lastname: Hirche
mesh_terms: D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D002370:Casts, Surgical; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007279:Injections, Subcutaneous; D007869:Leg Injuries / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011446:Prospective Studies; D012646:Self Administration; D013924:Thrombophlebitis / Q000517:prevention & control*
chemical_list: D006495:Heparin, Low-Molecular-Weight
vernacular_title: Durchführung der ambulanten Thromboseprophylaxe mit niedermolekularem Heparin bei Gipsimmobilisation der unteren Extremität.