title: [CD4 TIL (Tumor Infiltrating Lymphocytes) induce complete response in patients treated with IL-2 (Interleukin-2). Preliminary study].
abstract: This study analyzed clinical response induced by TIL in patients with renal cell carcinoma previously treated by interleukin-2. Six patients (4 men, 2 women, mean age 44.3 years) with measurable metastatic localizations have been treated by TIL reinjection (0.02 to 7.6 x 10(10) cells). TIL phenotype was a combination of CD4 and CD8 in 3 patients, predominantly CD4 in two patients and predominantly CD8 in one patient. Previous treatment by interleukin-2 induced one partial response, 2 stabilizations of the disease and 3 tumoral progressions. TIL led to an amelioration for 4 patients: 2 were in complete response, 2 were stabilized and 2 had tumoral progression and decreased. This study shows that CD4 TIL may improve an initially response induced by IL-2 therapy.
authors.affiliation: Clinique Urologique, Hôpital Cochin, Paris.
authors.forename: N
authors.initials: N
authors.lastname: Thiounn
authors.forename: C
authors.initials: C
authors.lastname: Mathiot
authors.forename: T
authors.initials: T
authors.lastname: Flam
authors.forename: E
authors.initials: E
authors.lastname: Tartour
authors.forename: C
authors.initials: C
authors.lastname: Peyret
authors.forename: I
authors.initials: I
authors.lastname: Joyeux
authors.forename: J P
authors.initials: JP
authors.lastname: Abecassis
authors.forename: M
authors.initials: M
authors.lastname: Zerbib
authors.forename: W H
authors.initials: WH
authors.lastname: Fridman
authors.forename: B
authors.initials: B
authors.lastname: Debré
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000637:transplantation*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007376:Interleukin-2 / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary; D016246:Lymphocytes, Tumor-Infiltrating / Q000637:transplantation*; D008297:Male; D008479:Mediastinal Neoplasms / Q000556:secondary; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000556:secondary
chemical_list: D007376:Interleukin-2
vernacular_title: Les TIL (Tumor Infiltrating Lymphocytes) CD4 induisent des résponses complètes chez des patients traités par IL-2 (Interleukin-2). Etude préliminaire.