Preparation and activity of derivatives of 1,2,3,4-tetrahydroisoquinoline- 4,6,8-triol, as potential beta-adrenergic blockers.
The new derivatives of 1,2,3,4-tetrahydroisoquinoline-4,6,8-triol were synthesized as a potential beta-adrenergic blockers. These compounds were obtained by simple modification of beta-adrenergic agonists (terbutaline, orciprenaline, fenoterole) and evaluated pharmacologically for their activity and binding to beta-adrenoreceptor.
Brzezińska
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Institute of Chemistry and Technology of Drugs, School of Medicine, Lódź, Poland.
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D044005:Tetrahydroisoquinolines
D000319:Adrenergic beta-Antagonists; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C014843:1,2,3,4-tetrahydroisoquinoline