title: The proximo-distal spread of axonal degeneration in the dorsal columns of the rat.
abstract: The pivotal event in Wallerian degeneration is the breakdown of the axon. Establishing the pathophysiology of axonal degeneration has implications for the understanding of the pathogenesis of other types of nerve degenerations. A key aspect of the pathophysiology is the spatiotemporal pattern of spread after transection, an issue that has remained controversial. We have studied the progression of axonal degeneration in the dorsal columns of the rat following L4L5L6 dorsal radiculotomy. Axonal degeneration proceeds in a proximo-distal fashion, beginning near the site of transection and spreading up the dorsal columns at a net rate of about 3 mm h-1. In addition, there was early degeneration of the preterminal axons in the gracile nuclei. This pattern suggests that the 'clearing' of axonally transported materials from the distal stump by continued anterograde transport may underlie axonal breakdown after transection.
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore MD 21287.
authors.forename: R
authors.initials: R
authors.lastname: George
authors.forename: J W
authors.initials: JW
authors.lastname: Griffin
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure; D005260:Female; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000648:ultrastructure; D009410:Nerve Degeneration; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure; D013126:Spinal Nerve Roots / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure; D013997:Time Factors