title: [Choleretic effects of Cassia alata Linn in the rat].
abstract: Fifty rats weighing average 200 g were used to study choleretic activity of Cassia alata LINN extract. Bile was collected according to acute biliarly fistula technic on animals anesthetized with 1.5g/kg of ethyle carbamate (Urethane ND). After determination of the minimal active dose (15 mg/kg) and lethal dose (100mg/kg) of the extract, rats were allowed in 5 groups of 10 each one: one reference group, one group receiving 15 mg/kg of Hydroxycyclohexenyl-butyrate (Hebecol ND) a synthetic choleretic, and 3 groups receiving respectively 15 mg/kg, 30 mg/kg and 60 mg/kg of Cassia alata extract. According to results obtained, choleretic activity of Cassia alata at 15 mg/kg is better than the Hebucol ND ones. But at elevated doses, the plant tend to inhibit bile secretion.
authors.affiliation: Laboratoire de physiologie, Pharmacodynamie-Thérapeutique, Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: Assane
authors.forename: M
authors.initials: M
authors.lastname: Traore
authors.forename: E
authors.initials: E
authors.lastname: Bassene
authors.forename: A
authors.initials: A
authors.lastname: Sere
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism*; D002366:Cassia; D004305:Dose-Response Relationship, Drug; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts
vernacular_title: Etude de l'activité cholérétique de Cassia alata Linn chez le rat.