title: [Evaluation of the immune status of children never treated wtih chemoantibiotics (children 3 to 6 years old)].
abstract: Six children aged between three and six years, born from undamaged families and free from malformative, chronic, degenerative or metabolic diseases, never treated with chemoantibiotics, were checked for their immune status. They were compared with other six children with the same somatic characteristics, the same health status and the same economical-social condition as the first six ones; but frequently treated with chemoantibiotics (not less than three therapy periods during each year of their life). The comparative study was performed by checking various parameters (lymphocyte blastization; rosette "E"; T3, T4, T8 lymphocytes with T4/T8 ratio; B lymphocytes; NK cells, chemotaxis; phagocytosis; killing; serum immunoglobulins A, G, M; C3; C4) index of immune functions, in uniform conditions. Results were statistically elaborated by means of "t-Student between groups test", "on ordinal ranks test", "t-Student for paired data test" and "Pearson's correlation coefficient" calculation. Significative differences by means of "t-Student between groups test" were recorded for what C3 is concerned, higher in never treated children, for PWM stimulation Blastization, lower in never treated children, for unstimulated blastization, chemotaxis and plasma IgM lower in frequently treated children. By means of "t-Student for paired data test" the above mentioned differences were confirmed and significantly higher values of plasma Immunoglobulin G and B lymphocyte in never treated children were pointed out. The differences between the last children and the controls are much higher than those previously recorded between similar groups 6-12 years old.
authors.affiliation: Istituto di Pediatria, Università degli Studi di Milano.
authors.forename: F
authors.initials: F
authors.lastname: Rosaschino
authors.forename: F
authors.initials: F
authors.lastname: Salvini
authors.forename: R
authors.initials: R
authors.lastname: Torre
authors.forename: G
authors.initials: G
authors.lastname: Cisarri
authors.forename: F
authors.initials: F
authors.lastname: Oleari
mesh_terms: D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets; D008297:Male; D012397:Rosette Formation
chemical_list: D000900:Anti-Bacterial Agents; D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Valutazione dello stato immunitario di bambini mai sottoposti a terapia chemioantibiotica (bambini dai 3 ai 6 anni).