title: The stumbler mutation maps to proximal mouse chromosome 2.
abstract: The cerebellar mouse mutation stumbler (stu) was mapped to proximal Chromosome (Chr) 2 with a recently developed polymerase chain reaction assay for endogenous retroviruses that vary between mouse strains. The stu locus resides between the markers D2Mit5 and D2Mit7. A number of developmentally or neurologically relevant candidate genes map in this region, including Bmi1, Dbh, Grin1, Notch1, Pax8, Rxra, and Spna2. Knowing the chromosomal localization of stu should simplify maintenance of the stumbler mouse stock and also enable analysis of the cerebellar defect in presymptomatic individuals.
authors.affiliation: Jackson Laboratory, Bar Harbor, Maine 04609.
authors.forename: W N
authors.initials: WN
authors.lastname: Frankel
authors.forename: H O
authors.initials: HO
authors.lastname: Sweet
authors.forename: M T
authors.initials: MT
authors.lastname: Davisson
mesh_terms: D000818:Animals; D001483:Base Sequence; D002524:Cerebellar Ataxia / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005819:Genetic Markers; D008297:Male; D051379:Mice / Q000235:genetics*; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction
chemical_list: D005819:Genetic Markers