A laser flash photolysis study of di-, tri- and tetrafluorinated phenylnitrenes; implications for photoaffinity labeling.
Several fluorinated aryl azides (2,6 and 2,4-difluorophenyl azide, 2,4,6-triflurorophenyl azide, and methyl 4-azido-2,3,5,6-tetrafluorobenzoate) were studied by laser flash photolysis techniques. In each case, the azides from singlet nitrenes which can be intercepted with pyridine to form ylides. This allowed determination of the rate constant for ring expansion of the singlet nitrene to the dehydroazepine and measurement of the absolute rate constants for reaction of the singlet nitrenes with typical quenchers.
Schnapp
K A
KA
Department of Chemistry, Ohio State University, Columbus 43210.
Platz
M S
MS
D000345:Affinity Labels / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D007834:Lasers; D010782:Photolysis; D013057:Spectrum Analysis
D000345:Affinity Labels; D001386:Azides; D005461:Fluorine