[Effect of trapidil in prevention of pre-eclampsia and fetal retardation].
Pre-eclampsia is suggested to be characterized by a functional imbalance between vascular prostacyclin and thromboxane A2 production. On the basis of this hypothesis it is attempted to correct this pathologic conditions by pharmacological manipulation with Trapidil, a triazolo pyrimidin derivative, because of its effects on the prostanoid metabolism. A prospective, randomized, double blind, placebo-controlled study was carried out to investigate Trapidil in the prevention of pregnancy-induced hypertension or pre-eclampsia. A total of 160 pregnant women with the risk to develop pre-eclampsia received Trapidil or placebo between week 24 and 38 of gestation. The number of patients in whom pregnancy-induced hypertension or pre-eclampsia developed was significantly lower in the Trapidil-treated (5.5%) compared with the placebo-treated group (14.1%). Additionally, a reduced risk of preterm deliveries and severe fetal growth retardation could be observed. In 7 patients with manifest pre-eclampsia or pregnancy-induced hypertension the circulating eicosanoid concentrations were determined before and during Trapidil medication. Trapidil was associated with an about twofold increase of 6-keto PGF1 alpha concentration in the peripheral venous blood, while the concentration of thromboxane A2 revealed no changes.
Nieder
J
J
Universitätsfrauenklinik, Otto-von-Guericke-Universität Magdeburg.
Claus
P
P
Augustin
W
W
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000517:prevention & control; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000097:blood / Q000517:prevention & control; D011225:Pre-Eclampsia / Q000097:blood / Q000517:prevention & control*; D011247:Pregnancy; D012307:Risk Factors; D014192:Trapidil / Q000008:administration & dosage* / Q000009:adverse effects
D015121:6-Ketoprostaglandin F1 alpha; D014192:Trapidil
Untersuchungen über den Einfluss von Trapidil zur Prävention von Präeklampsie und fetaler Retardierung.