Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes.
OBJECTIVE
To determine the relationship between urinary chiro-inositol excretion and insulin sensitivity in Japanese type II diabetic patients.


METHODS
Eighteen subjects were age-matched, nonobese, type II diabetic patients. Eight subjects had impaired glucose tolerance (IGT), and 10 had normal glucose tolerance (NGT). We quantified urinary chiro-inositol excretion using gas chromatography-mass spectrometry and the insulin sensitivity index (SI), and glucose effectiveness (SG) using Bergman's modified minimal model method.


RESULTS
The urinary excretion of chiro-inositol was much lower in the diabetic patients (32.3 +/- 16.0 mumol/day, means +/- SD) than in the NGT subjects (96.0 +/- 17.6; P < 0.0001) and IGT subjects (58.9 +/- 11.6; P < 0.0001). SI was much lower in the diabetic patients (3.81 +/- 1.49) than in the NGT subjects 6.30 +/- 1.59, P < 0.0005). SG was much lower in the diabetic patients (2.14 +/- 0.56) than in the NGT subjects (3.07 +/- 0.38, P < 0.0001). There was a significant correlation between urinary chiro-inositol excretion and SI (r = 0.766), as well as a significant correlation between urinary chiro-inositol excretion and SG (r = 0.747).
Suzuki
S
S
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Kawasaki
H
H
Satoh
Y
Y
Ohtomo
M
M
Hirai
M
M
Hirai
A
A
Hirai
S
S
Onoda
M
M
Matsumoto
M
M
Hinokio
Y
Y
D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000652:urine; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005951:Glucose Tolerance Test; D006801:Humans; D007294:Inositol / Q000652:urine*; D007333:Insulin Resistance / Q000502:physiology*; D007564:Japan; D008297:Male; D008875:Middle Aged
D007294:Inositol