Darlucins A and B, new isocyanide antibiotics from Sphaerellopsis filum (Darluca filum).
Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1,2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities.
Zapf
S
S
LB Biotechnologie der Universität, Kaiserslautern, FRG.
Hossfeld
M
M
Anke
H
H
Velten
R
R
Steglich
W
W
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003486:Cyanides / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D003512:Cyclohexanones / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D006873:Hydroquinones / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry* / Q000378:metabolism*; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D003486:Cyanides; D003512:Cyclohexanones; D006873:Hydroquinones; C092172:darlucin A; C092173:darlucin B