Accumbens microinjection of LY 171555 and sulpiride: effects on circling behaviour, in the rat.
In rats with unilateral 6-hydroxydopamine lesions of the substantia nigra (pars compacta) and amphetamine i.p. some parameters of the rotational activity, following intra-accumbens microinjection of D2 agonist (LY 171555) and antagonist (sulpiride), have been analyzed. An increase in the number of turns was observed with LY 171555, whereas sulpiride determined a decrease. The type of circling was also analyzed: D2 agonist induced a very close turn around the central axis of the animal and D2 antagonist a close turn in the centre of the cage. Data were compared with control condition, which exhibited a large turn around the walls of the cage. The results show that pharmacological manipulation of nucleus accumbens influences rotational behaviour with a specific role for D2 receptors.
Emmi
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Institute of Human Physiology, University of Palermo, Italy.
Crescimanno
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Amato
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D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004873:Ergolines / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D009714:Nucleus Accumbens / Q000502:physiology*; D016627:Oxidopamine; D019257:Quinpirole; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology*; D013563:Sympathectomy, Chemical
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D004873:Ergolines; D019257:Quinpirole; D013469:Sulpiride; D016627:Oxidopamine; D000661:Amphetamine