title: DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection.
abstract: DNA vaccination has been evaluated with the lymphocytic choriomeningitis virus (LCMV) model system. Plasmid DNA encoding the LCMV nucleoprotein, when injected intramuscularly, induces both antiviral antibodies and cytotoxic T lymphocytes. Injection of DNA encoding the nucleoprotein or the viral glycoprotein confers protection against normally lethal LCMV challenge in a major histocompatibility complex-dependent manner. The protection conferred is incomplete, but it is most probably mediated by the induced cytotoxic T lymphocytes.
authors.affiliation: Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: J L
authors.initials: JL
authors.lastname: Whitton
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004274:DNA, Recombinant / Q000008:administration & dosage / Q000494:pharmacology; D004279:DNA, Viral / Q000008:administration & dosage / Q000494:pharmacology*; D007114:Immunization; D008216:Lymphocytic Choriomeningitis / Q000517:prevention & control*; D008217:Lymphocytic choriomeningitis virus / Q000235:genetics / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010957:Plasmids; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000914:Antibodies, Viral; D004274:DNA, Recombinant; D004279:DNA, Viral; D014765:Viral Vaccines