Edematogenic responses induced by Bothrops jararaca venom in rats: role of lymphocytes.
The intraplantar injection of Bothrops jararaca venom (Bjv) caused an edematogenic response in the rat which was of rapid onset, and reached a peak in about 60 min. The response was markedly attenuated in animals rendered leucopenic by the administration of amethopterin. This inhibition was partially reverted when leucopenic rats were given i.v. suspensions of lymphocytes. Suspensions of neutrophils were ineffective. If the animals were submitted to an experimental obstruction of the thoracic duct, which leads to specific lymphocytopenia, similar inhibition of the edematogenic response was observed. These results suggest that lymphocytes can directly influence the development of the edema induced by Bothrops jararaca venom.
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Laboratory of Pathophysiology, Butantan Institute, São Paulo, Brazil.
Teixeira
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Sudo
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D000704:Analysis of Variance; D000818:Animals; D017837:Bothrops; D003435:Crotalid Venoms / Q000633:toxicity*; D004347:Drug Interactions; D004487:Edema / Q000139:chemically induced* / Q000188:drug therapy; D007958:Leukocyte Count / Q000187:drug effects; D007970:Leukopenia / Q000139:chemically induced; D008026:Ligation; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008231:Lymphopenia / Q000209:etiology; D008297:Male; D008727:Methotrexate / Q000494:pharmacology / Q000627:therapeutic use; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013897:Thoracic Duct / Q000601:surgery
D003435:Crotalid Venoms; D008727:Methotrexate