[Structural mutations of chromosome mutations induced by heavy metal salts during aging in vivo and in vitro].
The cytogenetic effect of inorganic copper (CuSO4) and cadmium (CdCl2) salts was studied in cells of long-term (144-hour) human cultures (in vitro model of aging) and in elderly individuals (80-93 years old). Copper sulfate increased the incidence of aberrant cells both in elderly individuals (14.25 +/- 1.74%) and during in vitro aging (12.20 +/- 1.62%) (3.94 +/- 1.96% and 5.25 +/- 1.10% in the controls, respectively), whereas treatment with cadmium chloride did not induce any changes in the background index. Differences in the effect of the studied salts may be due to their different effects on chromatin modification.
Dzhokhadze
T A
TA
Lezhava
T A
TA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D002478:Cells, Cultured; D002712:Chlorides / Q000633:toxicity*; D002869:Chromosome Aberrations; D003300:Copper / Q000633:toxicity*; D019327:Copper Sulfate; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009153:Mutagens / Q000633:toxicity*
D002712:Chlorides; D009153:Mutagens; D002104:Cadmium; D003300:Copper; D019256:Cadmium Chloride; D019327:Copper Sulfate
Izuchenie strukturnykh mutatsiĭ khromosom indutsirovannykh soliami tiazhelykh metallov pri starenii in vivo i in vitro.