[Hydroxyproline in serum and urine in children with pulmonary hypertension in the course of congenital heart defects].
In accordance to contemporary views on the pathology of biochemical changes in the fibrotic process at pulmonary hypertension, the authors took a trial to investigate the convection of excessive blood flow through lungs and changes of collagen metabolism in lungs. The possibility of following the metabolism of collagen through naming its metabolites (hydroxyproline-Hp) made us to connect the intended surveys with practical trail of its use, and diagnostic methods at children with congenital shunt cardiac defects. The survey was taken up in three groups of children with different levels of pulmonary advancement hypertension process: 39 children with dynamic elevation of pulmonary artery pressure (I st and II nd group age range: 12 months to 2 years), and 17 children with marks of pulmonary vascular obstructive disease. III rd group age range: 12 months to 6 years. It was stated, that between children from the first and second group before operational treatment, clear growth of Hp contents in serum and in urine returned to its correct value within the 1 to 6 months observation period since the cardiac defect has been corrected. In the third group, in spite of surgical treatment, the increased Hp content remained in the post operative period, therefore testifying the non-retreated fibrotic changes. It was stated, that Hp content control in serum and excretion in urine can possess clinical usage as an auxiliary exam estimating the advancement of pulmonary hypertension before surgical treatment and at the post-operative monitoring of the lungs.
Skalski
J
J
Kliniki Kardiochirurgii Slaskiej Akademii Medycznej, Katowicach.
Kortys-Puchalska
E
E
Komarski
K
K
Zmuda
A
A
Wites
M
M
Bochenek
A
A
Rokicki
W
W
D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000378:metabolism; D006330:Heart Defects, Congenital / Q000150:complications* / Q000601:surgery; D006801:Humans; D006909:Hydroxyproline / Q000097:blood* / Q000652:urine*; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D007223:Infant; D011184:Postoperative Period
D003094:Collagen; D006909:Hydroxyproline
Hydroksyprolina w surowicy i moczu u dzieci z nadciśnieniem płucnym w przebiegu przeciekowych wad wrodzonych serca.