[The effect of beta-escin on metabolism in experimental liver steatosis in rats].
The aim of the study was to investigate the effect of beta-aescin on the selected indices of sugar and lipid metabolisms in blood and hepatic tissue. The study was performed under the conditions of toxic impairment of the liver caused by carbon tetrachloride or hydrazinsulphate which were used in order to evoke experimentally the steatosis of the liver. The study investigated whether beta-aescin can cause deterioration of hepatic steatosis. Carbon tetrachloride was administered to rats by stomach probe in dosis of 2.5 ml per kg of body weight, or hydrazinsulphate in dosis of 2 mmol per kg of body weight, i.m.. Twenty-four hours after administration of these two substances beta-aescin water solution was administered in dosis of 10 mg per kg of body weight by means of stomach probe. The analysis of blood and liver tissue samples discovered that beta-aescin did not affect the metabolic indices, steatosis of the liver did not become more profound. (Tab. 2, Fig. 11, Ref. 23.)
Ulicná
O
O
Farmakobiochemické laboratórium LFUK, Bratislava, Slovakia.
Cizová
M
M
Valachová
A
A
Brixová
E
E
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002251:Carbon Tetrachloride; D004928:Escin / Q000494:pharmacology*; D005234:Fatty Liver / Q000139:chemically induced / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006834:Hydrazines; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D006834:Hydrazines; C029424:hydrazine; D004928:Escin; D006003:Glycogen; D002251:Carbon Tetrachloride
Vplyv beta-escínu na metabolizmus pri experimentálnej steatóze pecene u potkana.