Discordance between results for serum troponin T and troponin I in renal disease.
Two patients were investigated for unexplained increases in troponin T. In the first patient, who had rhabdomyolysis and acute renal failure, troponin T reached a peak value of 13.50 micrograms/L (67.5-fold the upper reference limit). The second patient had chronic renal failure and the troponin T peak value was 2.85 micrograms/L (14.3-fold the upper reference limit). Clinical investigations indicated no evidence of myocardial damage. Serum or plasma specimens were analyzed for total creatine kinase (CK), CK-2 mass, CK-2 isoform ratio, myoglobin, troponin T, troponin I, and myosin light chains; all except troponin I were at above-normal concentrations. We also investigated six additional renal patients with above-normal troponin T; troponin I was slightly increased in only one of these six patients. Our findings demonstrate discordance between results for troponin T and troponin I in renal patients.
Bhayana
V
V
Department of Laboratory Medicine, University Hospital, (University of Western Ontario), London, Ontario, Canada.
Gougoulias
T
T
Cohoe
S
S
Henderson
A R
AR
D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology; D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D007527:Isoenzymes; D007674:Kidney Diseases / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male; D009211:Myoglobin / Q000097:blood; D009218:Myosins / Q000097:blood; D012016:Reference Values; D012206:Rhabdomyolysis / Q000150:complications; D014336:Troponin / Q000097:blood*; D019210:Troponin I; D020107:Troponin T
D007527:Isoenzymes; D009211:Myoglobin; D014336:Troponin; D019210:Troponin I; D020107:Troponin T; D003402:Creatine Kinase; D009218:Myosins