Marked prolongation of incompatible class I deficient heart allografts: paradoxical effects between primarily and secondarily vascularized allografts.
These studies argue strongly against the widespread use of skin grafts for rejection testing. Primarily vascularized grafts of a clinically grafted organ would seem to be much more relevant to future studies. These results suggest that the elimination of either class I or class II antigens in grafts or techniques to modulate these antigens or reduce the degree of incompatibility of these antigens by tissue typing should be actively pursued for solid organ grafting in the future.
Henretta
J
J
East Carolina University School of Medicine/University Medical Center, Greenville, North Carolina 27858.
Araneda
D
D
Pittman
K
K
Thomas
F
F
D000818:Animals; D003326:Coronary Circulation; D004562:Electrocardiography; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology* / Q000502:physiology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006650:Histocompatibility Testing; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D016038:Skin Transplantation / Q000276:immunology*; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D015395:Histocompatibility Antigens Class I