title: [Chlordane accumulations in adipose tissue of mice chronically exposed to chlordanes in indoor air].
abstract: Chlordane concentrations were analyzed in the adipose tissue of mice after prolonged inhalation of low levels of chlordanes in indoor air. After inhalation of 4.22-11.36 micrograms/m3 chlordanes (total of 5 compounds) in air for 1-6 months, high levels of chlordanes (4.19-11.63 ppm, total of 5 compounds and 2 metabolites) were found in the adipose tissue. Transnanochlor, which accounted for only 14% of the total chlordane in the inhaled air, showed a high percentage (50%) in the adipose tissue, followed by 2 metabolites, i.e., oxychlordane (25%) and heptachlorepoxide (22%). Little transchlordane, cis-chlordane, or heptachlor, which accounted for high percentages of the total chlordane inhaled, was detected in the adipose tissue. A low level of cis-nonachlor was observed in the adipose tissue, and its percentage was similar to that in the air (2%). The level of chlordane exposure and the adipose tissue chlordane concentration was closely correlated (r = 0.9077, p < 0.01), showed a dose-effect relationship. These findings suggest that chlordanes such as trans-nonachlor, oxychlordane, and heptachlorepoxide may accumulate in the adipose tissue of people living in an environment containing even low levels of chlordanes and that there is a risk from indoor air contamination by chlordanes.
authors.affiliation: Department of Hygiene and Public Health, Kagawa Medical School.
authors.forename: F
authors.initials: F
authors.lastname: Asakawa
authors.forename: F
authors.initials: F
authors.lastname: Jitsunari
authors.forename: H
authors.initials: H
authors.lastname: Shiraishi
authors.forename: S
authors.initials: S
authors.lastname: Suna
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: Y
authors.initials: Y
authors.lastname: Manabe
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D016902:Air Pollution, Indoor; D000818:Animals; D002706:Chlordan / Q000032:analysis*; D004781:Environmental Exposure; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D002706:Chlordan