title: Fudecalone, a new anticoccidial agent produced by Penicillium sp. FO-2030.
abstract: Penicillium sp. FO-2030, a soil isolate, was found to produce a new anticoccidial compound. The active compound, designated fudecalone, was isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative HPLC. The structure of fudecalone was elucidated to be 3,3a,6,6a,7,8,9,10-octahydro-1-hydroxy-4,7,7-trimethyl-1H-naphtho[1,8a- c]furan-6-one mainly by spectroscopic studies including various NMR measurements. The anticoccidial activity using cell systems indicated that schizont formation of monensin-resistant Eimeria tenella was completely inhibited by fudecalone at concentrations more than 16 microM.
authors.affiliation: Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tabata
authors.forename: H
authors.initials: H
authors.lastname: Tomoda
authors.forename: R
authors.initials: R
authors.lastname: Masuma
authors.forename: Y
authors.initials: Y
authors.lastname: Iwai
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003049:Coccidiostats / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D006224:Cricetinae; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D010407:Penicillium / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D013053:Spectrophotometry; D013237:Stereoisomerism
chemical_list: D003049:Coccidiostats; D009281:Naphthalenes; C092178:fudecalone