Caffeine clearance in the horse.
The pharmacokinetic properties of intravenously administered caffeine were studied in 10 horses using a commercially available automated enzyme immunoassay. The harmonic mean for the distribution half-life was 5.2 min (range 1.4-18.7). The harmonic mean for the elimination half-life was 10.18 h (range 6.82-20.92). The harmonic mean of the volume of distribution was 0.32 L/kg (range 0.22-0.53). There was no correlation between the dose of caffeine/kg body weight and the elimination half-life (Spearman's coefficient of rank correlation = 0.19).
Schumacher
J
J
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, AL 36849-5522.
Spano
J S
JS
Wilson
R C
RC
DeGraves
F J
FJ
Duran
S H
SH
Ruffin
D C
DC
D000818:Animals; D002110:Caffeine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006736:Horses / Q000378:metabolism*; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male
D002110:Caffeine