Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors.
The uptake of [3H]5-HT and the density (Bmax) as well as affinity (Kd) of 5-HT uptake sites labelled with [3H]paroxetine and of 5-HT2 receptors labelled by [3H]LSD were determined in platelets from 25 medication-free patients with major depression and 20 normal controls. The density (Bmax) of 5-HT2 receptors was found to be significantly increased (by 52%) in platelets from depressed patients, particularly females. No changes were found in the affinity (Kd) of 5-HT2 receptors and in 5-HT uptake or [3H]paroxetine binding parameters. Density of 5-HT2 receptors positively correlated with that of [3H]paroxetine sites in control but not in depressed subjects. No correlation was found between the HAMD scores and Bmax of [3H]LSD binding. The results suggest that upregulation of platelet 5-HT2 receptors is a useful biological marker in major depression, particularly in females.
Hrdina
P D
PD
Department of Psychiatry, University of Ottawa, Ontario, Canada.
Bakish
D
D
Chudzik
J
J
Ravindran
A
A
Lapierre
Y D
YD
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000493:pharmacokinetics; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000145:classification / Q000502:physiology*; D012737:Sex Factors; D015854:Up-Regulation / Q000502:physiology
D015415:Biomarkers; D011985:Receptors, Serotonin; D017374:Paroxetine; D008238:Lysergic Acid Diethylamide