title: Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses: 11 cases (1988-1992).
abstract: Ten horses with histologically confirmed squamous cell carcinoma (SCC) and 1 horse with presumptive SCC of the external genitalia were treated with a combination of surgical debridement and topical administration of 5-fluorouracil, or with topical treatment alone. Tumor remission was obtained in all horses except 1 in which owner compliance was deficient, and no recurrences have been reported. Topical use of 5-fluorouracil as a chemotherapeutic agent for treatment of genital lesions of SCC in horses should be considered as a viable alternative to radical surgical excision.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
authors.forename: L A
authors.initials: LA
authors.lastname: Fortier
authors.forename: M A
authors.initials: MA
authors.lastname: Mac Harg
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D003646:Debridement / Q000662:veterinary; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006734:Horse Diseases / Q000188:drug therapy* / Q000601:surgery; D006736:Horses; D008297:Male; D010412:Penile Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D012074:Remission Induction; D014846:Vulvar Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*
chemical_list: D005472:Fluorouracil