Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses: 11 cases (1988-1992).
Ten horses with histologically confirmed squamous cell carcinoma (SCC) and 1 horse with presumptive SCC of the external genitalia were treated with a combination of surgical debridement and topical administration of 5-fluorouracil, or with topical treatment alone. Tumor remission was obtained in all horses except 1 in which owner compliance was deficient, and no recurrences have been reported. Topical use of 5-fluorouracil as a chemotherapeutic agent for treatment of genital lesions of SCC in horses should be considered as a viable alternative to radical surgical excision.
Fortier
L A
LA
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
Mac Harg
M A
MA
D000287:Administration, Topical; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D003646:Debridement / Q000662:veterinary; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006734:Horse Diseases / Q000188:drug therapy* / Q000601:surgery; D006736:Horses; D008297:Male; D010412:Penile Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D012074:Remission Induction; D014846:Vulvar Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*
D005472:Fluorouracil