title: 99mTc-complexes of a pentadentate amine-oxime ligand.
abstract: Synthesis and characterization of a new pentadentate amine-oxime ligand, 3,3,11,11-tetramethyl-7-benzyl-4,7,10-triazatridecane-2,12- dionedioxime is reported. The technetium complexes of this ligand was formed by direct reduction of TcO4- in the presence of the ligand at pH 9. The radiochemical yield of the complex is greater than 95% with 10(-7) M 99TcO4-. The technetium complex formed is a positively charged chelate that elutes as a single peak on a reverse phase HPLC. Biodistribution studies in rats showed an uptake of 1.4% of the injected activity at 15 sec p.i. in heart, but the wash-out was fast. The high radiochemical purity and stability of this 99mTc-chelate indicate that these types of chelates hold potential for development of bifunctional chelating agents (BFCAs).
authors.affiliation: Isotope Division, Bhabha Atomic Research Center, Bombay, India.
authors.forename: M R
authors.initials: MR
authors.lastname: Pillai
authors.forename: C S
authors.initials: CS
authors.lastname: John
authors.forename: J M
authors.initials: JM
authors.lastname: Lo
authors.forename: D E
authors.initials: DE
authors.lastname: Troutner
authors.forename: M
authors.initials: M
authors.lastname: Corlija
authors.forename: W A
authors.initials: WA
authors.lastname: Volkert
authors.forename: R A
authors.initials: RA
authors.lastname: Holmes
mesh_terms: D000818:Animals; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011868:Radioisotopes / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C092287:3,3,11,11-tetramethyl-7-benzyl-4,7,10-triazatridecane-2,12-dionedioxime; D008024:Ligands; D011073:Polyamines; D011868:Radioisotopes