title: Effects of dietary thiouracil on thyroid activity, egg production, and eggshell quality in commercial layers.
abstract: The effects of thyroid suppression induced during the rearing period by providing various dietary thiouracil (TU) regimens on plasma thyroxine (T4) concentrations, growth, and subsequent egg production (EP) and eggshell quality were determined in Single Comb White Leghorn chickens. Thiouracil was provided in the feed at levels of 0, .1, and .2% from 0 to 6 wk of age in Experiment 1, and at levels of 0, .05, and .1% from 6 to 16 wk of age in Experiment 2. In both experiments, T4 concentrations were reduced during TU treatment. However, T4 later became elevated at 12 and 20 wk in both dosage level groups in Experiment 1. Additionally, BW and egg weights were suppressed by both TU treatments, and EP was reduced up to Week 23 in the .1% TU-treated birds and through Week 25 in the .2% TU-treated birds. No effects on EP were noted in Experiment 2, but feed consumption (FC) was reduced during Week 6 in birds fed .05% TU and during Weeks 6, 10, and 19 in birds fed .1% TU. Both liver and thyroid weights were increased in .1% TU-treated birds relative to controls at Week 16. Eggshell quality was affected only in Experiment 2, in which birds given .05% TU had a higher relative conductance, or maximum rate of water loss, at Week 38 than 0 and .1% TU dosage levels, and .1% TU-treated birds had a higher breaking strength than 0 and .05% TU-treated birds at Week 22.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Poultry Science, Mississippi State University 39762.
authors.forename: E D
authors.initials: ED
authors.lastname: Peebles
authors.forename: E H
authors.initials: EH
authors.lastname: Miller
authors.forename: C R
authors.initials: CR
authors.lastname: Boyle
authors.forename: J D
authors.initials: JD
authors.lastname: Brake
authors.forename: M A
authors.initials: MA
authors.lastname: Latour
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000502:physiology*; D004435:Eating / Q000187:drug effects; D004528:Egg Shell / Q000187:drug effects; D004531:Eggs; D005260:Female; D013223:Statistics as Topic; D013889:Thiouracil / Q000008:administration & dosage / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood
chemical_list: D013889:Thiouracil; D013974:Thyroxine