title: Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice.
abstract: In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo-inositol during acute and again during chronic relapsing EAE. The ratio of N-acetyl-aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.
authors.affiliation: Royal College of Surgeons Unit of Biophysics, Institute of Child Health, London, United Kingdom.
authors.forename: N E
authors.initials: NE
authors.lastname: Preece
authors.forename: S
authors.initials: S
authors.lastname: Amor
authors.forename: D
authors.initials: D
authors.lastname: Baker
authors.forename: D G
authors.initials: DG
authors.lastname: Gadian
authors.forename: J K
authors.initials: JK
authors.lastname: O'Neill
authors.forename: J
authors.initials: J
authors.lastname: Urenjak
mesh_terms: D018354:Alphavirus Infections / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003401:Creatine / Q000378:metabolism; D018792:Encephalitis, Viral / Q000378:metabolism* / Q000821:virology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism*; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D012672:Semliki forest virus; D013116:Spinal Cord / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism*
chemical_list: D013654:Taurine; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine