In vitro drug interaction between amantadine and classical antimalarial drugs in Plasmodium falciparum infections.
The interactions of amantadine with classical antimalarial drugs were evaluated against a chloriquine-resistant and a chloroquine-sensitive strain of Plasmodium falciparum in vitro. Amantadine potentiated the effect of chloroquine and quinine in both strains; it also potentiated the effect of mefloquine, halofantrine and primaquine in the chloroquine-resistant strain but had no effect in the chloroquine-sensitive strain. Amantadine had no effect on the response to pyrimethamine of either strain. Amantadine does not interfere with the activity of these compounds and may possibly enhance it.
Evans
S G
SG
Department of Experimental and Clinical Pharmacology, University of the Witwatersrand Medical School, Parktown, South Africa.
Havlik
I
I
D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D004357:Drug Synergism; D066298:In Vitro Techniques; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D002738:Chloroquine; D000547:Amantadine