Disorazol A, an efficient inhibitor of eukaryotic organisms isolated from myxobacteria.
A new antibiotic, disorazol, was isolated from the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 12. It is a macrocyclic compound containing two oxazole rings. The antibiotic acted against many fungi and mammalian cell cultures. The latter responded to extremely low doses (MIC 3-30 pg/ml). None of the tested bacteria and yeasts were inhibited.
Irschik
H
H
GBF, Gesellschaft für Biotechnologische Forschung, Dept. of Biology of Natural Products, Braunschweig, Germany.
Jansen
R
R
Gerth
K
K
Höfle
G
G
Reichenbach
H
H
D000818:Animals; D000935:Antifungal Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005347:Fibroblasts / Q000187:drug effects; D005658:Fungi / Q000187:drug effects / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D008826:Microbial Sensitivity Tests; D009231:Myxococcales / Q000737:chemistry* / Q000378:metabolism*; D010080:Oxazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
D000935:Antifungal Agents; D046911:Macromolecular Substances; D010080:Oxazoles; C092171:disorazol A