Sequence of a cDNA encoding chicken vasoactive intestinal peptide (VIP).
Mammalian pre-pro-vasoactive intestinal peptide (pre-proVIP) gives rise to the neuropeptides vasoactive intestinal peptide (VIP) and peptide histidine isoleucine amide (PHI). The cDNA encoding chicken VIP was cloned and sequenced. The region of chicken pre-proVIP homologous to the mammalian PHI region is not followed by an amidation signal. This unusual feature suggests that processing of the precursor may be different in the chicken.
McFarlin
D R
DR
Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA.
Lehn
D A
DA
Moran
S M
SM
MacDonald
M J
MJ
Epstein
M L
ML
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002645:Chickens / Q000235:genetics* / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics; D008969:Molecular Sequence Data; D010451:Peptide PHI / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D011485:Protein Binding; D011498:Protein Precursors / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals; D017422:Sequence Analysis, DNA; D014660:Vasoactive Intestinal Peptide / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism
D018076:DNA, Complementary; D010451:Peptide PHI; D011498:Protein Precursors; D021382:Protein Sorting Signals; D014660:Vasoactive Intestinal Peptide; C050933:vasoactive intestinal peptide precursor