The effect of ninjinyoeito on human aorta endothelial cells.
We studied the effect of Ninjinyoeito in relation to the endothelial cells of the human aorta. Ninjinyoeito produced a cell proliferation acceleration effect, resulting in suppression of the synthesis and acceleration of the disintegration of endothelin, which acts as a vasoconstrictor and vasopressor. Also, acceleration of the synthesis of prostacyclin, which shows antithrombosis and platelet coagulation suppressing effects, was observed. The results suggest that Ninjinyoeito accelerates physiological function of in vitro human aorta endothelial cells.
Uchiyama
Y
Y
Kanagawa Rehabilitation Institute, Japan.
Nakajima
S
S
Yoshida
K
K
Mizukawa
H
H
Haruki
E
E
D001011:Aorta / Q000166:cytology / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008516:Medicine, Chinese Traditional
D004365:Drugs, Chinese Herbal; C072867:ren-shen-yang-rong-tang