Leukocyte adhesion molecules in oral lichen planus: a T cell-mediated immunopathologic process.
Oral lichen planus exhibits features of a mucosal type IV immunopathologic process. Adhesion molecules involved in the trafficking and homing of T lymphocytes to the subepithelial compartment were assessed by immunohistochemical methods. Laminin, type IV collagen and type VII collagen extracellular matrix components at the epithelial-connective tissue junction are significantly increased and serve as ligands for beta 1 integrins on lymphocyte membranes. Endothelial-associated intercellular adhesion molecule 1 and extracellular matrix basement membrane components are also significantly increased in the submucosa. Keratinocyte expression of major histocompatibility complex class II molecules and intercellular adhesion molecule 1 may serve as ligands for lymphocyte T cell receptor complex and beta 2 integrins, respectively. These adhesion molecules are probably involved in the trafficking of lymphocytes to the epithelial connective tissue interface in response to as of yet undefined antigens.
Eversole
L R
LR
Section of Diagnostic Sciences, UCLA School of Dentistry, Los Angeles, California.
Dam
J
J
Ficarra
G
G
Hwang
C Y
CY
D000704:Analysis of Variance; D000818:Animals; D001485:Basement Membrane / Q000276:immunology; D002417:Cattle; D015815:Cell Adhesion Molecules / Q000276:immunology*; D016326:Extracellular Matrix Proteins / Q000276:immunology; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism; D017676:Lichen Planus, Oral / Q000276:immunology*; D009061:Mouth Mucosa / Q000276:immunology; D016201:Receptors, Lymphocyte Homing / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D016023:Integrins; D016201:Receptors, Lymphocyte Homing; D018799:Intercellular Adhesion Molecule-1; D005340:Fibrinogen