title: Enhanced translocation of particles from lungs by jaggery.
abstract: Because industrial workers in dusty or smoky environments seemed to experience no discomfort if they consumed the sugar cane product jaggery, experimental studies were undertaken to observe the effects of jaggery on dust-exposed rats. Rats with and without a single intratracheal instillation of coal dust (50 mg/rat) were orally gavaged with jaggery (0.5 g/rat, 5 days/week for 90 days). The enhanced translocation of coal particles from lungs to tracheobronchial lymph nodes was observed in jaggery-treated rats. Moreover, the jaggery reduced the coal-induced histological lesions and hydroxyproline contents of lungs. The lesions induced in omental tissue and regional lymph nodes by a single intraperitoneal injection of 50 mg each of coal and silica dust were modified by jaggery (0.5 g/rat, 5 days/week for 30 days). These findings along with the preventive action of jaggery on smoke-induced lung lesions suggest the potential of jaggery as protective agent for workers in dusty and smoky environments.
authors.affiliation: Industrial Toxicology Research Centre, Lucknow, India.
authors.forename: A P
authors.initials: AP
authors.lastname: Sahu
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis; D004391:Dust; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D031786:Saccharum
chemical_list: D004391:Dust; C060188:Gur; D010936:Plant Extracts; D003094:Collagen