Synthesis and pharmacological study of 5,6,8,9-tetrahydro-4H, 7H-pyrrolo[1,2-a]cyclopenta[b]thieno[3,2-f][1,4]diazepines.
The paper reports the synthesis of a series of 5,6,8,9-tetrahydro-4H, 7H-pyrrolo[1,2-a]cyclopenta[b]thieno-[3,2-f][1,4]diazepines and the results of the study on their CNS activity in mice. The pharmacological properties of a previously prepared series of 5,6,7,8,9,10-hexahydro-benzo-analogs is also described.
Vega
S
S
Instituto de Química Médica, CSIC, Madrid, Spain.
Gil
M S
MS
Darias
V
V
Sanchez Mateo
C C
CC
Exposito
M A
MA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002417:Cattle; D005260:Female; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001381:Azepines; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D011619:Psychotropic Drugs; D011963:Receptors, GABA-A