title: Coronary stenting decreases restenosis in lesions with early loss in luminal diameter 24 hours after successful PTCA.
abstract: BACKGROUND
  Early loss of minimal luminal diameter (MLD) after successful percutaneous transluminal coronary angioplasty (PTCA) is associated with a higher incidence of late restenosis.
  
  
  RESULTS
  Sixty-six patients (66 lesions) with > 0.3 mm MLD loss at 24-hour on-line quantitative coronary angiography were randomized into two groups: 1, Gianturco-Roubin stent (n = 33) and 2, Control, who received medical therapy only (n = 33). All lesions were suitable for stenting. Baseline demographic, clinical, and angiographic characteristics were similar in the two groups. Restenosis (> or = 50% stenosis) for the overall group occurred in 32 of 66 patients (48.4%) at 3.6 +/- 1-month follow-up angiography. Restenosis was significantly greater in group 2 than in group 1 (75.7% versus 21.2%, P < .001). Vascular complications (21.2% versus 0%) and length of hospital stay (7.3 +/- 1 versus 2.4 +/- 0.5 days, P < .01) were higher for the stent group. Although at follow-up there were no differences in mortality or incidence of acute myocardial infarction between the two groups, patients in the control group had a higher incidence of repeat revascularization procedures (73% versus 21%, P < .001).
  
  
  CONCLUSIONS
  In patients with successful PTCA but reduced luminal diameter demonstrated by repeat angiography at 24 hours, the Gianturco-Roubin stent appears to reduce angiographic restenosis at follow-up.
authors.affiliation: Cardiac Unit, Anchorena Hospital, Buenos Aires, Argentina.
authors.forename: A E
authors.initials: AE
authors.lastname: Rodriguez
authors.forename: O
authors.initials: O
authors.lastname: Santaera
authors.forename: M
authors.initials: M
authors.lastname: Larribau
authors.forename: M
authors.initials: M
authors.lastname: Fernandez
authors.forename: R
authors.initials: R
authors.lastname: Sarmiento
authors.lastname: Perez Baliño
authors.forename: J B
authors.initials: JB
authors.lastname: Newell
authors.forename: G S
authors.initials: GS
authors.lastname: Roubin
authors.forename: I F
authors.initials: IF
authors.lastname: Palacios
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000925:Anticoagulants / Q000627:therapeutic use; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000517:prevention & control / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants