title: Medical and surgical management of acute disseminated encephalomyelitis.
abstract: Two children with a recent history of viral illness developed visual loss secondary to optic neuritis. Clinical findings and neuroimaging were consistent with acute disseminated encephalomyelitis (ADEM). Markedly elevated opening pressures were noted on lumbar puncture. The patients demonstrated an initial favorable response to high-dose corticosteroid administration. Both had recurrence of symptoms after being tapered off oral corticosteroids. High-dose corticosteroids were reinstituted and a bilateral optic nerve sheath decompression was performed on one patient who developed profound visual loss. A second patient underwent a lumboperitoneal shunt. Both children had resolution of their symptoms and had a recovery of normal visual acuity.
authors.affiliation: Department of Ophthalmology, Cleveland Clinic Foundation, Ohio.
authors.forename: B D
authors.initials: BD
authors.lastname: Ellis
authors.forename: G S
authors.initials: GS
authors.lastname: Kosmorsky
authors.forename: B H
authors.initials: BH
authors.lastname: Cohen
mesh_terms: D001921:Brain / Q000473:pathology; D002675:Child, Preschool; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009902:Optic Neuritis / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D017287:Ventriculoperitoneal Shunt; D014777:Virus Diseases / Q000150:complications; D014786:Vision Disorders / Q000209:etiology
chemical_list: D003907:Dexamethasone