[Epileptic seizures and treatment with ifosfamide-mesna].
Generalized and partial seizures with secondary generalization were observed during ifosfamide-mesna (IFO) treatment in a patient with lung epidermoid carcinoma. Seizures appeared in a stereotyped manner on the 3rd of the 4th and 6th day of treatment with IFO. Partially resolutive confusion was observed after the last cure. Brain CTS were normal. The responsibility of IFO is considered in the development of these neurological toxic manifestations.
Somma-Mauvais
H
H
Service d'Explorations Fonctionnelles du Système Nerveux, CHU, Hôpital Sainte-Marguerite, Marseille.
Farisse
P
P
Viallat
J R
JR
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004827:Epilepsy / Q000139:chemically induced*; D017809:Fatal Outcome; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects* / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D015080:Mesna / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced*
D015080:Mesna; D007069:Ifosfamide
Crises épileptiques et traitement par ifosfamide-mesna.