Effect of [dl]-alpha-tocopherol on FeCl2-induced lipid peroxidation in rat amygdala.
Peroxidative injury of neural membrane lipids can be initiated by iron-containing blood products, chelated ferrous or ferric ions, and low valence iron in aqueous solution. Lipid peroxidation was measured following focal injection of 3 microliters of 100 mM FeCl2 into rat amygdala. Acute parenteral administration of [dl]-alpha-tocopherol as the alcohol limited the quantity of peroxidation products generated. These data suggest a potential role for alpha-tocopherol administration in limiting brain injury responses.
Triggs
W J
WJ
Department of Neurology, University of Florida College of Medicine, Gainesville.
Willmore
L J
LJ
D000679:Amygdala / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002712:Chlorides; D005290:Ferric Compounds / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014810:Vitamin E / Q000494:pharmacology*
D002712:Chlorides; D005290:Ferric Compounds; D008563:Membrane Lipids; D014810:Vitamin E; C024555:ferric chloride