title: Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.
authors.affiliation: Division of Biomedical Sciences, Sheffield Hallam University, England.
authors.forename: W R
authors.initials: WR
authors.lastname: Chegwidden
authors.forename: L E
authors.initials: LE
authors.lastname: Wagner
authors.forename: P J
authors.initials: PJ
authors.lastname: Venta
authors.forename: N C
authors.initials: NC
authors.lastname: Bergenhem
authors.forename: Y S
authors.initials: YS
authors.lastname: Yu
authors.forename: R E
authors.initials: RE
authors.lastname: Tashian
mesh_terms: D002256:Carbonic Anhydrases / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D004789:Enzyme Activation / Q000235:genetics; D006801:Humans; D006868:Hydrolysis; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D015032:Zinc / Q000378:metabolism*
chemical_list: D002256:Carbonic Anhydrases; D015032:Zinc