[Pericarditis during inflammatory bowel diseases. Extra-intestinal or iatrogenic complication?].
Acute pericarditis is rarely associated with inflammatory bowel disease. In such cases, when usual aetiologies have been excluded, pericarditis can be considered to be either an extraintestinal manifestation of inflammatory bowel disease or due to an adverse drug effect. We report a case of acute pericarditis in a 17-year old patient with ulcerative colitis treated with mesalazine for 15 days. Mesalazine was discontinued with a prompt and spontaneous resolution of the symptoms. Extensive investigations revealed no known cause for his pericarditis. Eight days and 75 days after the diagnosis, a lymphoblastic transformation test in the presence of mesalazine was performed and was positive for concentration greater than or equal to 10 micrograms/mL; this test was negative in 3 control patients treated with mesalazine without adverse drug effect. This observation together with the rare documented cases allows to consider the possibility that pericarditis may be caused by an adverse drug reaction in these patients.
Heresbach
D
D
Service d'Hépato-Gastroentérologie, CHRU Pontchaillou, Rennes.
Rabot
A
A
Génetet
N
N
Marteau
P
P
Stéphan
C
C
Bretagne
J F
JF
Gosselin
M
M
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000636:Aminosalicylic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D019804:Mesalamine; D010493:Pericarditis / Q000139:chemically induced*
D000305:Adrenal Cortex Hormones; D000636:Aminosalicylic Acids; D019804:Mesalamine
Péricardite au cours des maladies inflammatoires intestinales. Complication extra-intestinale ou iatrogène?