Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis.
Interleukin-9 (IL-9) is a multifunctional cytokine produced by activated TH2 clones in vitro and during TH2-like T cell responses in vivo. The IL-9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signal transduction. Various observations indicate that IL-9 is actively involved in mast cell responses by inducing the proliferation and differentiation of these cells. The role of IL-9 in T cell responses is less clear. Although freshly isolated normal T cells do not respond to IL-9, this cytokine induces the proliferation of murine T cell lymphomas in vitro and in vivo overexpression of IL-9 results in the development of thymic lymphomas. In the human, the existence of an IL-9-mediated autocrine loop has been suggested for some malignancies such as Hodgkin's disease. Other potential biological targets for IL-9 include B lymphocytes, hematopoietic progenitors, and immature neuronal cell lines.
Renauld
J C
JC
Ludwig Institute for Cancer Research, Catholic University of Louvain, Brussels, Belgium.
Kermouni
A
A
Vink
A
A
Louahed
J
J
Van Snick
J
J
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D002895:Chromosomes, Human, Pair 5; D005796:Genes; D006801:Humans; D016906:Interleukin-9 / Q000502:physiology*; D008407:Mast Cells / Q000166:cytology*; D051379:Mice; D008969:Molecular Sequence Data; D018123:Receptors, Interleukin / Q000502:physiology*; D053651:Receptors, Interleukin-9; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000166:cytology*
C508045:IL9R protein, human; D016906:Interleukin-9; D018123:Receptors, Interleukin; D053651:Receptors, Interleukin-9