title: Effect of rifampicin on theophylline pharmacokinetics in human beings.
abstract: Theophylline pharmacokinetics before and after rifampicin administration was studied in 10 healthy volunteers. It was seen that Rifampicin significantly increased the volume of distribution of theophylline by 23.41% (p < 0.01) and its metabolic clearance by 47.65% (P < 0.05). This has got clinical significance in the treatment of patients of pulmonary tuberculosis with chronic obstructive airways disease where both the drugs may have to be given concurrently.
authors.affiliation: Department of Tuberculosis and Chest Diseases, GSVM Medical College, Kanpur.
authors.forename: S
authors.initials: S
authors.lastname: Rao
authors.forename: S K
authors.initials: SK
authors.lastname: Singh
authors.forename: R K
authors.initials: RK
authors.lastname: Narang
authors.forename: P T
authors.initials: PT
authors.lastname: Rajagopalan
mesh_terms: D000328:Adult; D004357:Drug Synergism; D006801:Humans; D008875:Middle Aged; D012293:Rifampin / Q000494:pharmacology*; D013806:Theophylline / Q000493:pharmacokinetics*
chemical_list: D013806:Theophylline; D012293:Rifampin