title: [Inhibition of elastin hydrolysis, catalyzed by human leukocyte elastase and cathepsin G, by the Bowman-Birk type soy inhibitor].
abstract: Cathepsin G stimulates the hydrolysis of elastin from bovine neck ligament catalyzed by human leukocyte elastase. Stimulation factor depends on the ratio of the enzyme concentrations and ionic strength and equals 1.0-2.0. The classical Bowman-Birk inhibitor from soya retards strongly the hydrolysis of elastin catalyzed by leukocyte elastase, cathepsin G and the mixture of both. The inhibitory effect is practically unaffected by the adsorption of the enzymes on elastin, prolongation of the enzymatic reaction and ionic strength.
authors.forename: T V
authors.initials: TV
authors.lastname: Tikhonova
authors.forename: I P
authors.initials: IP
authors.lastname: Gladysheva
authors.forename: N F
authors.initials: NF
authors.lastname: Kazanskaia
authors.forename: N I
authors.initials: NI
authors.lastname: Larionova
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002384:Catalysis; D056649:Cathepsin G; D002403:Cathepsins / Q000378:metabolism*; D002417:Cattle; D004549:Elastin / Q000037:antagonists & inhibitors*; D006801:Humans; D006868:Hydrolysis; D019272:Leukocyte Elastase / Q000378:metabolism*; D007962:Leukocytes / Q000201:enzymology*; D008969:Molecular Sequence Data; D009994:Osmolar Concentration; D010196:Pancreatic Elastase / Q000378:metabolism*; D012697:Serine Endopeptidases; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000494:pharmacology*
chemical_list: D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D004549:Elastin; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase
vernacular_title: Ingibirovanie soevym ingibitorom tipa Baumana-Birk gidorliza élastina, kataliziruemogo élastazoĭ i katepsinom G iz leĭkotsitov cheloveka.