Conversion of antinuclear antibody specificity as a marker of deterioration of cutaneous lupus erythematosus into lupus nephritis.
A 34-year-old male systemic lupus erythematosus patient (SLE) with cutaneous vasculitis developed renal failure after switching anti-nuclear antibody (ANA) specificity. He developed cutaneous lupus erythematosus with homogeneous and speckled type ANA and a high titer of anti-DNA antibody without renal involvement at 21 years of age. After developing lupus nephritis at the age of 27, the original ANA disappeared gradually. Two years later, a discrete speckled type ANA titer elevated abruptly to as high as 1:640 with low complementemia and without DNA antibody. Within five years, he suffered renal failure. This case of SLE suggests a direct correlation with ANA pattern and organ involvement.
Kihira
C
C
Department of Dermatology, Mie University School of Medicine, Tsu, Japan.
Mizutani
H
H
Shimizu
M
M
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications* / Q000276:immunology; D008181:Lupus Nephritis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D008297:Male
D000974:Antibodies, Antinuclear