A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.
INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH). MATERIAL AND METHODS-A 50-year-old woman was followed-up for 15 years clinically and paraclinically after a heavy PHT intoxication. Her immunoglobulins in serum were checked on PHT and after 15 years treatment with carbamazepine. RESULTS-A gross mass of hyperplasia tissue found primarily in the left side of her mouth had disappeared and serum IgA which was subnormal at the first visit had normalized. CONCLUSION-It is possible to prevent GH from PHT treatment by intensive dental care, correct mouth hygiene and by change of treatment of carbamazepine.
Tigaran
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Neurology Clinic, Hvidovre Hospital, Copenhagen, Denmark.
D000328:Adult; D002220:Carbamazepine / Q000008:administration & dosage; D002544:Cerebral Infarction / Q000150:complications; D004305:Dose-Response Relationship, Drug; D004828:Epilepsies, Partial / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D005885:Gingival Hyperplasia / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D009910:Oral Hygiene; D010672:Phenytoin / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use
D002220:Carbamazepine; D010672:Phenytoin