[Rostral ventrolateral medulla-sympathetic vasoconstrictor nerve system mediated insular cortex-pressor response].
In urethane-anesthetized, tubocurarine-immobilized and artificially ventilated rats, microinjection of L-glutamate (Glu) into the insular cortex (INS) caused a rise in blood pressure and heart rate. Bilateral injection of either phentolamine, propranolol or atropine into the rostral ventrolateral medulla (RVL) all could decrease the INS-pressor response. The latter could also be attenuated by phentolamine (i.v.), but not by propranolol or methyl atropine. These results indicate that the INS-pressor response is mediated by RVL (alpha-, beta- and M-receptors) -sympathetic vasoconstrictor nerve system.
Xu
W K
WK
Department of Physiology, Beijing Medical University.
Gu
Y H
YH
D000818:Animals; D001794:Blood Pressure; D002540:Cerebral Cortex / Q000502:physiology*; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D010646:Phentolamine / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000502:physiology*; D014661:Vasoconstriction
D005971:Glutamates; D011433:Propranolol; D010646:Phentolamine