title: How cells know they are in G1 or G2.
abstract: How does a cell know if it's in G1 or G2 and should proceed to S phase or mitosis? This is a restatement of the question of how a cell ensures mitosis is dependent upon S phase, and S phase is dependent upon mitosis. Several gene products have been identified which play important roles in maintaining these interdependencies. Central to these controls are oscillations between different complexes of cyclins and cyclin-dependent kinases.
authors.affiliation: Cell Cycle Laboratory, Imperial Cancer Research Fund, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Connell
authors.forename: P
authors.initials: P
authors.lastname: Nurse
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism; D016193:G1 Phase / Q000502:physiology*; D016195:G2 Phase / Q000502:physiology*; D006801:Humans; D008540:Meiosis / Q000502:physiology; D008938:Mitosis; D016196:S Phase
chemical_list: D016213:Cyclins; D018844:Cyclin-Dependent Kinases