Copper-induced acute rhabdomyolysis in Wilson's disease.
Wilson's disease is a lethal defect in copper metabolism causing a continual increase in tissue copper concentrations that become toxic to the liver, brain, kidney, eye, skeletal system, and several other tissues and organs. The liver is unique among these in being both the site of the etiologic biochemical abnormality and the organ that is always affected by copper toxicosis. Although myocardial muscle involvement has been reported in association with Wilson's disease, copper deposits in peripheral muscle tissue have not yet been described. A case of a young patient with Wilson's disease who developed recurrent episodes of acute rhabdomyolysis is presented, and the accumulation of copper in muscle tissue as a possible complication is discussed.
Propst
A
A
Department of Internal Medicine, University of Innsbruck, Austria.
Propst
T
T
Feichtinger
H
H
Judmaier
G
G
Willeit
J
J
Vogel
W
W
D000085:Acetates / Q000627:therapeutic use; D019342:Acetic Acid; D000208:Acute Disease; D000293:Adolescent; D001706:Biopsy; D003300:Copper / Q000378:metabolism*; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008297:Male; D009132:Muscles / Q000378:metabolism / Q000473:pathology; D010396:Penicillamine / Q000627:therapeutic use; D012008:Recurrence; D012206:Rhabdomyolysis / Q000209:etiology* / Q000473:pathology
D000085:Acetates; D003300:Copper; D010396:Penicillamine; D019342:Acetic Acid