title: Noradrenergic innervation of the external granular layer of the rat following low-level X-irradiation.
abstract: The distribution of the noradrenergic system within the rat cerebellar cortex following low-level X-irradiation was studied using tyrosine hydroxylase immunocytochemistry. X-Irradiation treatments consisted of 1, 3, or 5 successive daily dose beginning on postnatal day 1. When studied 24 h after the last exposure, a dense plexus of tyrosine hydroxylase-like immunoreactive (THIR) fibers, not found in age-matched controls, was observed in the reduced external granular layer (EGL) in each treatment group. At 10 days of age, the THIR fibers were found in association with the reconstituted cells of the premigratory zone of the EGL. The rapid and abnormal innervation of the EGL by the THIR fibers suggests that the noradrenergic system could play a role in the regeneration of this layer.
authors.affiliation: Terre Haute Center for Medical Education, Indiana University School of Medicine 47809.
authors.forename: P E
authors.initials: PE
authors.lastname: Kunkler
authors.forename: W J
authors.initials: WJ
authors.lastname: Anderson
mesh_terms: D000818:Animals; D002525:Cerebellar Cortex / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D009412:Nerve Fibers / Q000528:radiation effects / Q000648:ultrastructure; D009416:Nerve Regeneration; D009638:Norepinephrine / Q000502:physiology; D011689:Purkinje Cells / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D051381:Rats; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*; D014965:X-Rays
chemical_list: D014446:Tyrosine 3-Monooxygenase; D009638:Norepinephrine