Chemomyectomy of the orbicularis oculi muscles for the treatment of localized hemifacial spasm.
OBJECTIVE
To report our experience with doxorubicin chemomyectomy as an alternative to other treatments for hemifacial spasm (HFS).


METHODS
A prospective, open study Phase I clinical trial of chemomyectomy.


METHODS
A hospital-based, referral neuro-ophthalmology and oculoplastic service.


METHODS
Repeated (1-6, median: 4) local injections of doxorubicin were given in the eyelids of 8 patients (5 men, 3 women, average age: 71).


METHODS
Eyelid strength, self-reported spasm, and duration of improvement without seeking additional or alternative treatments.


RESULTS
Chemomyectomy resulted in permanent (> or = 2.5 years) orbicularis oculi weakness and relief from spasms in the treated areas in 5 patients, although 2 patients requested occasional supplementary botulinum toxin (BT) injections in the facial muscles over the cheek. One patient had a successful result for 3 years, after which spasm recurred. One patient maintains a successful result in the eyelid but had a failed microvascular decompression in the lower face. One incompletely treated patient required microvascular decompression following spread of spasms to the lower branches of the facial nerve and increased severity of the HFS. One patient required eyelid surgery because of concurrent spastic entropion. One patient treated with a higher concentration than currently used required closure of a skin ulcer.


CONCLUSIONS
Doxorubicin chemomyectomy is an effective alternative to conventional therapy for properly selected patients affected by HFS, particularly older patients with relatively localized eyelid muscle spasms. The modified technique of doxorubicin chemomyectomy has developed to the point where its safety is demonstrated and its risks are known.
Wirtschafter
J D
JD
Department of Ophthalmology, University of Minnesota Medical School, Minneapolis.
D000368:Aged; D000369:Aged, 80 and over; D001764:Blepharospasm / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D005143:Eyelids / Q000187:drug effects / Q000294:innervation; D005152:Facial Muscles; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009121:Muscle Denervation / Q000379:methods; D009801:Oculomotor Muscles; D011446:Prospective Studies; D013035:Spasm / Q000188:drug therapy*
D004317:Doxorubicin