Effects of benzpyrene and allylestrenol administered during pregnancy on the sexual behaviour of castrated and hormone treated adult rats.
Treatments with benzpyrene on the 15th, 17th and 19th day of the pregnancy result in sexually significantly less active offspring females following castration and treatments with sexual hormones in adulthood. The receptivity of animals treated with allylestrenol in embryonic period is also decreased but was not significant. Treatments with allylestrenol or benzpyrene of newborns did not alter the hormone-induced sexual behaviour. Comparing with our previous experiments it seems that the effect of benzpyrene--which is structurally more distinct however it binds to the steroid receptor--is more pronounced on the sexual behaviour than allylestrenol.
Karabélyos
C
C
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Dalló
J
J
Csaba
G
G
D000500:Allylestrenol / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001580:Benzopyrenes / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D001580:Benzopyrenes; D011374:Progesterone; D004958:Estradiol; D000500:Allylestrenol