title: Neurocircuitry of the basal ganglia studied by monitoring neurotransmitter release. Effects of intracerebral and perinatal asphyctic lesions.
abstract: The neurocircuitries of the basal ganglia are studied with in vivo microdialysis, with special consideration to dopamine transmission and its interaction with other neurotransmitter systems. The aim is to develop experimental models to study the pathophysiology and therapy of neurodegenerative disorders of the basal ganglia, as well as to develop models to study the short- and long-term consequences of perinatal asphyctic lesions. A main goal of these studies is to find and to characterize new treatments for these disorders.
authors.affiliation: Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Herrera-Marschitz
authors.forename: C F
authors.initials: CF
authors.lastname: Loidl
authors.forename: Z B
authors.initials: ZB
authors.lastname: You
authors.forename: K
authors.initials: K
authors.lastname: Andersson
authors.forename: R
authors.initials: R
authors.lastname: Silveira
authors.forename: W T
authors.initials: WT
authors.lastname: O'Connor
authors.forename: M
authors.initials: M
authors.lastname: Goiny
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001237:Asphyxia / Q000378:metabolism; D001479:Basal Ganglia / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D017551:Microdialysis; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism; D051381:Rats
chemical_list: D018377:Neurotransmitter Agents