[A novel extended-spectrum beta-lactamase in a ceftazidime-resistant isolate of E. coli].
A novel extended-spectrum beta-lactamase (ESbla) encoded on a plasmid of approximately 7.5kb, conferring resistance to beta-lactams tested except cefoxitin and imipenem, was found in a ceftazidime-resistant isolate of E. coli form our hospital. The resistance to beta-lactams was transferred by conjugation to E. coli JP559 together with the aminoglycosides and sulfonamide resistance. Clavulanate, one of beta-lactamase inhibitors, inhibited its activity. This ESbla gene hybridized neither with an intra-genic fragment of SHV-1 nor with that of TEM-1. The molecular origin of that novel ESbla needed to be further studied.
Cheng
Y
Y
Beijing Union Medical College Hospital, Chinese Academy of Medical Sciences.
Li
Y
Y
Chen
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology*; D003227:Conjugation, Genetic; D018432:Drug Resistance, Multiple / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D011815:R Factors; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents; D002442:Ceftazidime; D001618:beta-Lactamases