title: Long-term changes in urodynamic studies of voiding in the elderly.
abstract: Urodynamic studies were conducted in 80 incontinent elderly patients (27 men and 53 women; mean age, 77 years) and repeated 2-4 weeks later after patients had been subject to interventions. Interpretable voiding studies were performed in 84% of sessions. Interpretable initial and repeat studies were performed in 74% of patients. For detrusor pressure at maximum flow the intra-individual, between-sessions variability was +/- 11.7 cm H2O (SD) and the initial-repeat correlation coefficient was 0.61. For maximum flow rate the corresponding figures were +/- 4.7 ml/s and 0.44. Mean residual urine volume was 195 ml, with a between-sessions variability of +/- 113 ml (SD). These results suggest that there is substantial long-term variability in voiding function, including urethral resistance. Of the mean, 5% showed a change in obstruction classification (unobstructed/obstructed) between sessions. This variability and the modest proportion of interpretable studies should be taken into account when assessing urethral obstruction and designing clinical trials.
authors.affiliation: Urodynamics Unit, Edmonton General Hospital, Alberta, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Griffiths
authors.forename: G
authors.initials: G
authors.lastname: Harrison
authors.forename: K
authors.initials: K
authors.lastname: Moore
authors.forename: P
authors.initials: P
authors.lastname: McCracken
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000627:therapeutic use; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use; D014524:Urethral Obstruction / Q000188:drug therapy / Q000503:physiopathology*; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology*; D014549:Urinary Incontinence / Q000188:drug therapy / Q000503:physiopathology*; D014556:Urine; D014563:Urodynamics / Q000187:drug effects / Q000502:physiology*
chemical_list: D008333:Mandelic Acids; D010276:Parasympatholytics; C005419:oxybutynin