T cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus-infected asymptomatic subjects.
The predictive value of low T cell reactivity to CD3 monoclonal antibodies for development of AIDS was evaluated and compared with low CD4+ cell numbers and the presence of syncytium-inducing human immunodeficiency virus (HIV) variants in 122 seropositive asymptomatic homosexual men for 4.5 years. Low T cell reactivity was a strong predictor for progression to AIDS in a multivariate proportional hazards analysis using these markers as covariates at entry and as time-dependent covariates. The combination of the three markers was associated with development of AIDS in 6 of 7 men within 15 months. In contrast, the group that lacked any of these markers had a very low risk (11%) for developing AIDS. In groups with one or two of these three markers, progression rates were 33% and 66%, respectively. These data demonstrate that measurement of T cell function in vitro is of value for staging of HIV infection and may be useful for monitoring therapy.
Roos
M T
MT
Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Miedema
F
F
Koot
M
M
Tersmette
M
M
Schaasberg
W P
WP
Coutinho
R A
RA
Schellekens
P T
PT
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D015415:Biomarkers; D018791:CD4 Lymphocyte Count; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D013601:T-Lymphocytes / Q000276:immunology*
D015415:Biomarkers