Pancreatic xenograft survival in diabetic rabbits.
Prolonged survival of pancreatic xenografts in the muscles of diabetic rabbits was achieved. The mean graft survival time (assessed by euglycemic status) in nonimmunosuppressed (Group A) was 10 days and in immunosuppressed (Group B) was 36 days (P < 0.05). Adequate immunosuppression helps pancreatic xenograft to normalize blood glucose level (BGL) by prolonging survival time. Our study demonstrates that xenotransplantation of islet cells in their natural environment (pancreatic tissue in four of thin slices) survive and function adequately in immunosuppressed recipients. This discordant Xenotransplantation model may be useful for future xenotransplantation studies.
Gupta
R C
RC
Department of Medicine, Pharmacology, Pathology and Biochemistry, J L N Medical College, Ajmer.
Mathur
A K
AK
Sharma
P
P
Vanjani
R M
RM
Sharma
P K
PK
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000473:pathology* / Q000601:surgery; D006041:Goats; D006085:Graft Survival / Q000502:physiology*; D007165:Immunosuppression Therapy; D016035:Pancreas Transplantation / Q000473:pathology / Q000502:physiology*; D011817:Rabbits; D013997:Time Factors; D014183:Transplantation, Heterologous
D001786:Blood Glucose