The role of CD8+ T cells in the pathogenesis of atopic asthma.
The role of the CD8+ T cells, a specialized subset of T cells, in the pathogenesis of atopic asthmatics is presented on the basis of the latest data. Thus the authors discuss the regulatory role of the CD8+ T cells in the synthesis of IgE, the environmental factors which activate preferentially the CD8+ cells as well as other factors such as histamine, the leukochemoattractant factor, PGE2, IFN gamma and IL-4 which also contribute to the activation of these cells thus demonstrating their role of down-regulating the immune response in asthmatics without the T helper or T cytotoxic.
Stanciu
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Institute of Hygiene and Public Health, Cluj-Napoca, Romania.
D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology* / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007073:Immunoglobulin E