title: The role of psychological coronary risk factors in insulin and glucose metabolism.
abstract: The association between psychological coronary risk factors and serum insulin, and C-peptide and blood glucose concentrations, [the latter measured while fasting and during the oral glucose tolerance test (OGTT)], was examined in healthy middle-aged men (n = 64). The results indicate that among the evaluated psychological risk factors, high levels of hostile paranoia and vital exhaustion were most consistently associated with an enhanced insulin/glucose ratio, and enhanced insulin, C-peptide and glucose responses during OGTT. The associations persisted after controlling for age, smoking, alcohol consumption and visceral fat distribution. Thus, in addition to age, life-style factors and obesity, psychological factors may have an effect on insulin and glucose metabolism.
authors.affiliation: Department of Psychology, University of Helsinki, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Räikkönen
authors.forename: L
authors.initials: L
authors.lastname: Keltikangas-Järvinen
authors.forename: A
authors.initials: A
authors.lastname: Hautanen
mesh_terms: D000328:Adult; D000786:Anger; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology* / Q000209:etiology; D005951:Glucose Tolerance Test; D006791:Hostility; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000523:psychology; D010259:Paranoid Disorders / Q000150:complications / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D014434:Type A Personality
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin