title: Increased incidence of rejection in patients with delayed graft function.
abstract: Because of the difficulties in diagnosing rejection in patients with delayed graft function, such patients were routinely biopsied 7-10 days after kidney transplantation. We found histologic evidence of rejection in 48% of the cases during the lst month posttransplant, a proportion that was significantly higher than in patients with immediate graft function. Furthermore, the 2-year graft survival in patients with delayed graft function and rejection, but not in those without rejection, was significantly lower than in patients with immediate function. The results suggest that there is an association between delayed graft function and rejection and that rejection is the component responsible for the decreased graft survival previously reported for patients with delayed graft function.
authors.affiliation: Department of Surgery, University of Florida, Gainesville 32610.
authors.forename: R J
authors.initials: RJ
authors.lastname: Howard
authors.forename: W W
authors.initials: WW
authors.lastname: Pfaff
authors.forename: M E
authors.initials: ME
authors.lastname: Brunson
authors.forename: J C
authors.initials: JC
authors.lastname: Scornik
authors.forename: E L
authors.initials: EL
authors.lastname: Ramos
authors.forename: J C
authors.initials: JC
authors.lastname: Peterson
authors.forename: R S
authors.initials: RS
authors.lastname: Fennell
authors.forename: B P
authors.initials: BP
authors.lastname: Croker
mesh_terms: D000328:Adult; D001706:Biopsy; D002102:Cadaver; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology*; D006085:Graft Survival / Q000276:immunology / Q000502:physiology; D006801:Humans; D007165:Immunosuppression Therapy; D015994:Incidence; D016030:Kidney Transplantation / Q000276:immunology / Q000473:pathology / Q000502:physiology*; D008297:Male; D011184:Postoperative Period; D012086:Reoperation; D013997:Time Factors; D014019:Tissue Donors