Real-time, in vivo measurement of radiation dose during radioimmunotherapy in mice using a miniature MOSFET dosimeter probe.
This report presents the first real-time measurement of absorbed radiation dose during radioimmunotherapy in mice. Dose rate and total dose at the center of the tumor were measured after administration of 90Y-labeled antibodies using a miniature metal oxide semiconductor field-effect transistor radiation dosimeter probe which was inserted into the center of the tumor volume. Continuous real-time measurements were made for as long as 23 h after injection of the radiolabeled antibodies. Comparison of the real-time dose-rate measurements with estimates based on the MIRD formalism indicates good agreement. The real-time measurements are further compared to measurements made in a second experiment in which groups of mice were sacrificed at individual times after injection of the same radiolabeled antibodies. The real-time measurements agree well with the measurements in excised tumors. The real-time measurements have greater time resolution and are much more efficient than traditional uptake measurements.
Gladstone
D J
DJ
Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts 02115.
Chin
L M
LM
D000818:Animals; D051379:Mice; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000295:instrumentation*; D016499:Radioimmunotherapy; D014407:Tumor Cells, Cultured