Current aspects in metal genotoxicity.
While carcinogenic metal ions are mostly non-mutagenic in bacteria, different types of cellular damage have been observed in mammalian cells, which may account for their carcinogenic potential. Two modes of action seem to be predominant: the induction of oxidative DNA damage, best established for chromium compounds, and the interaction with DNA repair processes, leading to an enhancement of genotoxicity in combination with a variety of DNA damaging agents. In the case of Cd(II), Ni(II), Co(II), Pb(II) and As(III), DNA repair processes are disturbed at low, non-cytotoxic concentrations of the respective metal compounds. Even though different steps in DNA repair are affected by the diverse metals, one common mechanism might be the competition with essential metal ions.
Hartwig
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Department of Biology and Chemistry, University of Bremen, Germany.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D008670:Metals / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*
D002273:Carcinogens; D008670:Metals; D009153:Mutagens