[Interruption of perinatal transmission of HBV by Chinese recombinant hepatitis B vaccine].
Sixty-two infants who were born from HBsAg and HBeAg both positive mothers were vaccinated with 20 micrograms/dose recombinant hepatitis B vaccine, which was made in Beijing Institute of Biologic Products (Vaccinia virus recombinant hepatitis B vaccine) and Changchun Institute of Biologic Products (Chinese hamster ovary cells recombinant hepatitis B vaccine), at 0, 1, 6 months. All the babies were followed up for 9 or 12 months. The results showed that the protective rates of Beijing vaccine and Changchun vaccine were 79.2% and 80.2%, respectively, the positive rates of anti-HBs were 78.8% and 79.3%, respectively. Local or systematic reactions were not found in all the babies 3 days after injection. These results suggested that the Chinese recombinant hepatitis B vaccine was safe and effective. It was better than the plasma vaccine with the same dose.
Yang
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C
Sichuan Provincial Hygiene and Epidemic Prevention Center, Chengdu.
Chen
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D
Li
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S
D005260:Female; D006509:Hepatitis B / Q000517:prevention & control* / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D014611:Vaccination; D014614:Vaccines, Synthetic
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic