UBP5 encodes a putative yeast ubiquitin-specific protease that is related to the human Tre-2 oncogene product.
A gene from chromosome V of the yeast Saccharomyces cerevisiae has been cloned and sequenced. The deduced amino acid sequence encoded by this gene is similar to several ubiquitin-specific proteases from yeast, especially at the highly conserved domain. It is thus named UBP5. UBP5 is also closely related to the human Tre-2 and the mouse Unp oncogene products. This study adds a new member to the ubiquitin protease family and suggests that alteration of ubiquitin protease activity may result in cancer in mammals. However, disruption of the UBP5 gene in a haploid strain did not result in a noticeable phenotypic alteration.
Xiao
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Department of Microbiology, University of Saskatchewan, Saskatoon, Canada.
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Tang
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D000595:Amino Acid Sequence; D001483:Base Sequence; D015825:Chromosomes, Fungal; D010450:Endopeptidases / Q000737:chemistry / Q000235:genetics*; D005800:Genes, Fungal; D016681:Genome, Fungal; D006801:Humans; D008969:Molecular Sequence Data; D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion / Q000737:chemistry*; D011518:Proto-Oncogene Proteins; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D043222:Ubiquitin Thiolesterase; D014452:Ubiquitins / Q000378:metabolism
D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D014452:Ubiquitins; D010450:Endopeptidases; C473330:USP6 protein, human; D043222:Ubiquitin Thiolesterase; C059237:ubiquitin-Nalpha-protein hydrolase