title: Ipsilateral breast tumor recurrence following conservative surgery and radiation therapy.
abstract: Ipsilateral breast tumor recurrence occurs in approximately 10% to 15% of patients undergoing conservative surgery and definitive radiation therapy. Mammography alone detects one third of breast recurrences. Most recurrences are invasive, few demonstrate simultaneous distant metastasis, and approximately 40% have axillary lymph node involvement. Mastectomy is the standard salvage procedure. Axillary lymph node dissection may help guide adjuvant treatment as well as reduce the risk of a subsequent regional recurrence. The decision of whether to use adjuvant therapy should be based on tumor size, lymph node status, receptor status, DNA index, S-phase fraction, and disease-free interval. Ipsilateral recurrence may be an independent prognostic factor for distant metastasis.
authors.affiliation: Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick.
authors.forename: R S
authors.initials: RS
authors.lastname: DiPaola
authors.forename: S G
authors.initials: SG
authors.lastname: Orel
authors.forename: B L
authors.initials: BL
authors.lastname: Fowble
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D001943:Breast Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008197:Lymph Node Excision; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors