The effect of andrographis paniculata nees (APN) in alleviating the myocardial ischemic reperfusion injury.
In experimental dogs, the effect of APN in alleviating the ischemia-reperfusion injury was prominent. Compared with the sustained ischemia group, superoxide dismutase (SOD) in the ischemic region of myocardial tissue in the ischemia-reperfusion group was significantly decreased and malondialdehyde (MDA) markedly increased: Ca2+ in myocardial cells was increased; and ultrastructural changes of myocardial tissues were severe. In the APN-pretreated ischemia-reperfusion group, on the contrary, all the above parameters showed reversely, i.e., SOD increased, MDA and intracellular Ca2+ decreased, the ultrastructure changes were less distorted.
Guo
Z L
ZL
Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan.
Zhao
H Y
HY
Zheng
X H
XH
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000378:metabolism
D015220:Calcium Channels; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase