Potent glycogenic effect of GLP-1(7-36)amide in rat skeletal muscle.
GLP-1(7-36)amide is an intestinal post-translational proglucagon product released mainly after carbohydrate ingestion, the glucose dependent insulinotropic and antidiabetogenic actions of which have been documented. In this work, by exploring whether GLP-1(7-36)amide has any effect on the glucose metabolism of the muscle, we have observed that this peptide, at physiological concentrations, exerts in this tissue an increment of the D-[U-14C]glucose incorporated into glycogen, which is accompanied by an increase in the glycogen synthase a activity; also, it stimulates both glucose oxidation and lactate formation. These data indicate that the skeletal muscle is one of the target tissues for GLP-1(7-36)amide, where its insulin-like effect explains, at least in part, its plasma glucose lowering action; thus, GLP-1(7-36)amide may well be implicated in the physiological control of glucose homeostasis after meals, not only by acting as an incretin, but also by directly promoting glucose disposal.
Villanueva-Peñacarrillo
M L
ML
Department of Metabolism, Nutrition and Hormones, Fundacióń Jimenez Diaz, Madrid, Spain.
Alcántara
A I
AI
Clemente
F
F
Delgado
E
E
Valverde
I
I
D000818:Animals; D005934:Glucagon / Q000494:pharmacology; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010762:Phosphorylase a / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; D007773:Lactates; D018377:Neurotransmitter Agents; D010446:Peptide Fragments; C055453:glucagon-like peptide 1 (7-36)amide; D019344:Lactic Acid; D004763:Glucagon-Like Peptides; D052216:Glucagon-Like Peptide 1; D006003:Glycogen; D005934:Glucagon; D010762:Phosphorylase a; D006006:Glycogen Synthase; D005947:Glucose