title: Bioequivalency evaluation by comparison of in vitro dissolution and in vivo absorption using reference equations.
abstract: Using in vitro dissolution and in vivo absorption of different generics or batches for an appropriate drug and dosage form, a reference equation of form: ka = a+bkd+dkd2 can be proposed. In the case of availability of standardised in vitro-in vivo data for a specific drug, a Level A a correlation of this type containing experimentally determined a, b, d parameters would serve to predict in vivo absorption phase of the drug. The larger number of batches, the stronger will be the predictive power of these parameters.
authors.affiliation: Department of Fundamental Pharmaceutical Sciences, Faculty of Pharmacy, University of EGE, Izmir, Türkiye.
authors.forename: A
authors.initials: A
authors.lastname: Kayali
mesh_terms: D000042:Absorption; D012995:Solubility; D013810:Therapeutic Equivalency; D013816:Thermodynamics