title: Itraconazole for the treatment of histoplasmosis in cats.
abstract: Eight cats with histoplasmosis were treated with itraconazole at 5 mg/kg per dose PO bid. There were multiple sites of infection, and 2 of the cats had hypercalcemia that was attributed to the histoplasmosis. All 8 cats were eventually cured, but 2 cats experienced recurrences of disease after completion of therapy, requiring 2 to 3 additional months of itraconazole. There were no clinically relevant adverse effects during treatment. Although a limited number of cats were treated, the study suggests that itraconazole is a well-tolerated and effective drug for the treatment of histoplasmosis in the cat.
authors.affiliation: Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
authors.forename: R D
authors.initials: RD
authors.lastname: Hodges
authors.forename: A M
authors.initials: AM
authors.lastname: Legendre
authors.forename: L G
authors.initials: LG
authors.lastname: Adams
authors.forename: M D
authors.initials: MD
authors.lastname: Willard
authors.forename: R P
authors.initials: RP
authors.lastname: Pitts
authors.forename: K
authors.initials: K
authors.lastname: Monce
authors.forename: C C
authors.initials: CC
authors.lastname: Needels
authors.forename: H
authors.initials: H
authors.lastname: Ward
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000382:microbiology; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D004361:Drug Tolerance; D005260:Female; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000188:drug therapy / Q000662:veterinary*; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D017964:Itraconazole