The human serotonin 5-hydroxytryptamine1D receptor pseudogene is transcribed.
An examination of mRNA expression of the serotonin genes encoding both psi 5HT1D alpha and the related 5HT1D alpha, demonstrated that the pseudogene is transcribed, and has a tissue distribution similar to the 5HT1D alpha receptor-encoding gene. This psi 5HT1D alpha transcript is capable of being translated into a polypeptide of only 28 amino acids in length, and the psi 5HT1D alpha pseudogene most likely arose from a gene duplication or transposition event.
Bard
J A
JA
Synaptic Pharmaceutical Corporation, Paramus, NJ 07652.
Nawoschik
S P
SP
O'Dowd
B F
BF
George
S R
SR
Branchek
T A
TA
Weinshank
R L
RL
D000595:Amino Acid Sequence; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D009928:Organ Specificity; D014176:Protein Biosynthesis; D011544:Pseudogenes / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
D012333:RNA, Messenger; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin