[Diprivan and liver].
No evidence of hepatoxicity has been demonstrated with propofol. Propofol can be used for anaesthesia in patients suffering from moderate cirrhosis of the liver. Liver blood flow is preserved. Propofol dosage must be titrated to each patient's needs. Data concerning the use of propofol in patients suffering from severe hepatic failure or cholestasis are lacking. Propofol dosage in chronic alcoholic patients without cirrhosis must be increased.
Servin
F
F
Département d'Anesthésie-Réanimation, Hôpital Bichat, Paris.
D006801:Humans; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000378:metabolism*; D008111:Liver Function Tests; D008657:Metabolic Clearance Rate; D015742:Propofol / Q000378:metabolism / Q000494:pharmacology*
D015742:Propofol
Diprivan et foie.