Antimutagenicity of eugenol in the rodent bone marrow micronucleus test.
The antimutagenic effect of eugenol on the mutagenicity of cyclophosphamide (CP), mitomycin C (MMC), ethyl methanesulfonate (EMS) and benzo[a]pyrene (B[a]P) was assessed in the rodent bone marrow micronucleus test using male Swiss mice. Oral administration of eugenol (0.4% in the diet) for 15 days was found to decrease significantly the frequency of micronucleated polychromatic erythrocytes (MPEs) elevated by CP. No effect was found on the frequency of MPEs elevated by MMC, EMS and B[a]P. The results provide some support for antimutagenic potency of eugenol in vivo.
Rompelberg
C J
CJ
TNO Nutrition and Food Research Institute, AJ Zeist, The Netherlands.
Stenhuis
W H
WH
de Vogel
N
N
van Osenbruggen
W A
WA
Schouten
A
A
Verhagen
H
H
D000284:Administration, Oral; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D003520:Cyclophosphamide / Q000633:toxicity; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D005054:Eugenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D016685:Mitomycin / Q000633:toxicity; D016296:Mutagenesis / Q000187:drug effects*
D016587:Antimutagenic Agents; D005054:Eugenol; D016685:Mitomycin; D003520:Cyclophosphamide; D005020:Ethyl Methanesulfonate