[Systemic lupus erythematosus in men--a different prognosis?].
A retrospective analysis of 21 male and 82 female patients with systemic lupus erythematosus (SLE) was performed in order to identify sex-linked differences in disease manifestations. As organ manifestation, cardiac involvement was assessed in 12 of 21 male patients (57%) and in 18 of 82 females (22%; p < 0.05). Renal involvement occurred in 16 male (76%) vs 26 female patients (32%; p < 0.05). Endstage renal disease developed in 5 of the 21 men (24%), but only in 6 of the 82 women (7%) with SLE. The most striking clinical result was the high frequency of thrombembolic complications in male SLE-patients. Twelve out of 21 males (57%) experienced more than 30 thrombembolic events in contrast to 9 events in 5 out of 82 females (6%; p < 0.0001). Persisting elevated IgG-anti-cardiolipin antibodies were found in 48% of male and only 16% of female patients (p < 0.05). In conclusion, these data suggest that SLE in males is characterized by more frequent and severe organ involvement and especially by striking prevalence of partly life-threatening thrombembolic complications.
Specker
C
C
Abteilung für Endokrinologie und Rheumatologie, Heinrich Heine-Universität Düsseldorf.
Becker
A
A
Lakomek
H J
HJ
Bach
D
D
Grabensee
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood; D002423:Cause of Death; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D008181:Lupus Nephritis / Q000175:diagnosis / Q000276:immunology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012737:Sex Factors; D015996:Survival Rate; D013923:Thromboembolism / Q000175:diagnosis / Q000276:immunology / Q000401:mortality
D017153:Antibodies, Anticardiolipin; D007074:Immunoglobulin G
Systemischer Lupus Erythematodes bei Männern--Eine andere Krankheitsprognose?