Severe generalized hyperkinesia to nicardipine SR therapy.
A patient who was taking nicardipine SR for angina management suffered two episodes of severe involuntary tonic and clonic muscular contractions, involving both upper extremities and torso without loss of consciousness. This tardive dyskinesia occurred in the absence of hypotension and cardiac rhythm disorder. Intravenous diazepam promptly controlled these symptoms. The precise etiology of the dyskinesia is not clear and its relation to nicardipine remains speculative as the patient refused rechallenge with the drug. Possible hypothesis for tardive dyskinesia and nicardipine are presented.
Das
G
G
UND School of Medicine, Fargo.
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D003692:Delayed-Action Preparations; D003975:Diazepam / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D009529:Nicardipine / Q000009:adverse effects*
D003692:Delayed-Action Preparations; D009529:Nicardipine; D003975:Diazepam