Animal models of Lyme disease: pathogenesis and immunoprophylaxis.
Valuable insights into the pathogenesis and immunoprophylaxis of Lyme disease are beginning to emerge from studies in animal models. This review highlights two animal models: the mouse, which has allowed us to investigate the role of both the immune response and spirochete phenotype in determining the outcome of the disease; and the Rhesus monkey, which manifests signs of nerve involvement, in addition to showing erythema migrans and arthritis.
Philipp
M T
MT
Tulane University Medical Center, Tulane Regional Primate Research Center, Covington, LA 70433.
Johnson
B J
BJ
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D015748:Borrelia burgdorferi Group / Q000472:pathogenicity*; D003257:Consumer Product Safety; D004195:Disease Models, Animal; D006801:Humans; D008193:Lyme Disease / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D008253:Macaca mulatta; D051379:Mice; D008809:Mice, Inbred C3H; D016896:Treatment Outcome
D001428:Bacterial Vaccines