title: Cytogenetic changes in ovarian mucinous cystadenocarcinoma of low malignant potential with persistent pseudomyxoma peritonei.
abstract: Minimal cytogenetic data are available for low malignant potential ovarian neoplasms, and none for those complicated by pseudomyxoma peritonei. Cytogenetic analysis was performed on tissue obtained from a patient undergoing repeat evacuation of mucin and mucin-producing implants in pseudomyxoma peritonei originating from an ovarian mucinous cystadenocarcinoma of low malignant potential. Specimens obtained from intraperitoneal implants during one of the cyto/mucin-reductive procedures revealed a mixture of normal female karyotype (46,XX) and an abnormal karyotype with a deletion involving the short arm of chromosome 1, and a balanced translocation involving chromosomes 2 and 6, [46,XXdel(1)(p21p31), t(2;6)(q35;p21)]. The vast majority of the cells from three subsequent cyto/mucin-reductive procedures displayed a normal female karyotype with few cells containing random abnormalities.
authors.affiliation: City of Hope National Medical Center, Department of Gynecology, Duarte, California 91010.
authors.forename: S A
authors.initials: SA
authors.lastname: Vasilev
authors.forename: A M
authors.initials: AM
authors.lastname: Meloni
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000368:Aged; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics*; D010534:Peritoneal Neoplasms / Q000235:genetics*; D011553:Pseudomyxoma Peritonei / Q000235:genetics*