title: Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group.
abstract: BACKGROUND
  Dexmedetomidine, a highly selective alpha 2-adrenergic agonist, increases perioperative hemodynamic stability in healthy patients but decreases blood pressure and heart rate. The goal of this study was to evaluate, in a preliminary manner, the hemodynamic effects of perioperatively administered dexmedetomidine in surgical patients at high risk for coronary artery disease.
  
  
  METHODS
  Twenty-four vascular surgery patients received a continuous infusion of placebo or one of three doses of dexmedetomidine, targeting plasma concentrations of 0.15 ng/ml (low dose), 0.30 ng/ml (medium dose), or 0.45 ng/ml (high dose) from 1 h before induction of anesthesia until 48 h postoperatively. All patients received standardized anesthesia and hemodynamic management. Blood pressure, heart rate, and Holter ECG were monitored; additional monitoring included continuous 12-lead ECG preoperatively, anesthetic concentrations and myocardial wall motion (echocardiography) intraoperatively, and cardiac enzymes postoperatively.
  
  
  RESULTS
  Preoperatively, there was a decrease in heart rate (low dose 11%, medium dose 5%, high dose 20%) and systolic blood pressure (low dose 3%, medium dose 12%, high dose 20%) in patients receiving dexmedetomidine. Intraoperatively, dexmedetomidine groups required more vasoactive medications to maintain hemodynamics within predetermined limits. Postoperatively, demedetomidine groups had less tachycardia (minutes/monitored hours) than the placebo group (placebo 23 min/h; low dose 9 min/h, P = 0.006; medium dose 0.5 min/h, P = 0.004; high dose 2.3 min/h, P = 0.004). Bradycardia was rare in all groups. There were no myocardial infarctions or discernible trends in the laboratory results.
  
  
  CONCLUSIONS
  Infusion of dexmedetomidine up to a targeted plasma concentration of 0.45 ng/ml appears to benefit perioperative hemodynamic management of surgical patients undergoing vascular surgery but required greater intraoperative pharmacologic intervention to support blood pressure and heart rate.
authors.affiliation: Department of Anesthesia, University of California, San Francisco 94143-0648.
authors.forename: P
authors.initials: P
authors.lastname: Talke
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: U
authors.initials: U
authors.lastname: Jain
authors.forename: J
authors.initials: J
authors.lastname: Leung
authors.forename: K
authors.initials: K
authors.lastname: Drasner
authors.forename: M
authors.initials: M
authors.lastname: Hollenberg
authors.forename: D T
authors.initials: DT
authors.lastname: Mangano
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation; D003327:Coronary Disease / Q000601:surgery; D004311:Double-Blind Method; D017548:Echocardiography, Transesophageal; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000009:adverse effects; D020926:Medetomidine; D017202:Myocardial Ischemia / Q000150:complications; D014656:Vascular Surgical Procedures / Q000379:methods*
chemical_list: D007093:Imidazoles; D020926:Medetomidine