Salt preference elicited by chronic intracerebroventricular angiotensin II.
1. Much more water was consumed than either 0.9% or 2.7% saline in response to various dipsogenic stimuli in untreated normal replete rats when they had free access to water, 0.9% and 2.7% saline. On the other hand, the rats drank more 0.9% saline than water and 2.7% saline when each solution is the sole drinking fluid offered. 2. A marked increase in preference for 0.9% saline was observed during the chronic i.c.v. injection of angiotensin II at a dose of 25 ng/hr for 7 consecutive days in the three bottle choice test. After the cessation of angiotensin II infusion, most rats (45 out of 50 rats) returned to drink much more water than 0.9% and 2.7% saline, similar to the drinking pattern of the 0.9% saline-treated control rats. However, some rats (5 out of 50 rats) still preferred 0.9% saline and this persisted for up to 3 months although these rats did not show a hypertensive state and an increase of plasma renin activity.
Izumi
H
H
Department of Physiology, Tohoku University School of Dentistry, Sendai, Japan.
Nakamura
I
I
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure; D002755:Choice Behavior / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D012462:Saline Solution, Hypertonic; D012982:Sodium, Dietary / Q000008:administration & dosage*
D012462:Saline Solution, Hypertonic; D012982:Sodium, Dietary; D000804:Angiotensin II; D012083:Renin