Fish protein-rich diet attenuates hypertension induced by dietary NG-nitro-L-arginine in normotensive Wistar-Kyoto rats.
1. Dietary 0.023% NG-nitro-L-arginine (L-NNA), an inhibitor of nitric oxide synthesis, induced hypertension in normotensive Wistar-Kyoto rats (WKY). This hypertension was significantly attenuated in WKY given a fish protein-rich diet. 2. The supplement of 2% L-arginine given in a standard diet or a diet containing 3% taurine for drinking did not significantly affect the development of hypertension induced by L-NNA in WKY. 3. WKY which received the standard diet mixed with 10% urea and 0.023% L-NNA had significantly attenuated hypertension compared with WKY receiving the standard diet mixed with 10% kaolin and 0.023% L-NNA. 4. These results suggest that the attenuation of hypertension in L-NNA-treated WKY rats given a fish protein rich diet may be partly caused by urea, a metabolic end-product of protein.
Gutierrez
O G
OG
Department of Pathology, Shimane Medical University, Shimane Institute of Health Science, Izumo, Japan.
Ikeda
K
K
Nara
Y
Y
Deguan
G U
GU
Yamori
Y
Y
D000818:Animals; D001120:Arginine / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D004044:Dietary Proteins / Q000627:therapeutic use*; D005399:Fishes; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000145:classification* / Q000628:therapy; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D014508:Urea / Q000494:pharmacology
D004044:Dietary Proteins; D014508:Urea; D001120:Arginine