title: Sex determination. Turning on sex.
abstract: The orphan nuclear receptor, steroidogenic factor 1, is central to the differentiation of male and female mammalian gonads. It controls the fate of the initially bipotential gonad as well as later male-specific functions.
authors.affiliation: Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Smith
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005260:Female; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010053:Ovary / Q000196:embryology; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*; D012733:Sex Differentiation / Q000235:genetics / Q000502:physiology*; D054339:Steroidogenic Factor 1; D013737:Testis / Q000196:embryology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014998:Y Chromosome
chemical_list: D004268:DNA-Binding Proteins; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; C515057:NR5A1 protein, human; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; C515058:steroidogenic factor 1, mouse