Survival of the Q fever agent Coxiella burnetii in the phagolysosome.
The Q fever agent, Coxiella burnetii, thrives in the acidic environment of the phagolysosome of the host cell. How this obligate intracellular agent manages to survive within this hostile milieu is unknown; however, several of its enzymes may eliminate or prevent the formation of toxic oxygen metabolites by the host cell. Also implicated as virulence factors are its surface lipopolysaccharide and plasmids.
Baca
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OG
Dept of Biology, University of New Mexico, Albuquerque 87060.
Li
Y P
YP
Kumar
H
H
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002460:Cell Line; D016997:Coxiella burnetii / Q000201:enzymology* / Q000254:growth & development*; D005347:Fibroblasts; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008070:Lipopolysaccharides / Q000378:metabolism; D008247:Lysosomes / Q000382:microbiology*; D008264:Macrophages; D051379:Mice; D010587:Phagocytosis; D011778:Q Fever / Q000382:microbiology*; D013482:Superoxide Dismutase / Q000378:metabolism
D008070:Lipopolysaccharides; D002374:Catalase; D013482:Superoxide Dismutase; D000135:Acid Phosphatase