title: Interactions of fluoride and non-fluoride agents with the caries process.
abstract: Fundamental to the caries process and its inhibition is an understanding of the composition and structural relationships of dental mineral. These have received greater study in recent years, leading to a better understanding of the processes involved. Fluoride has been the most successful of the anti-caries agents to date, and many studies have concentrated on this ion. The anti-caries action of fluoride has been only partially explained by the early finding that fluoride-treated mineral was less soluble, and this criterion is now less widely accepted. The dissolutive process of caries is inhibited by fluoride, monofluorophosphate, trimetaphosphate, and zinc. However, only the first three of these show anti-caries activity. The presence of fluoride during in vivo and in vitro caries is conducive to the formation of an apparently intact surface zone. Current evidence is that this zone reforms during the caries process, thus acquiring fluoride and having larger crystallites compared with sound enamel. Trimetaphosphate also favors the formation of a surface zone. There is a clear beneficial involvement of fluoride, even at low levels, in the process of lesion remineralization. It is highly probable that this process results from re-growth of residual enamel crystallites rather than de novo precipitation of calcium phosphates. Levels of fluoride found in saliva can interact with dental mineral. Although zinc has been shown to adsorb upon apatite mineral and to restrict subsequent crystal growth, it does not appear to affect the action of fluoride, including remineralization, adversely. This may be due to the fact that the uptake of zinc is reversible.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Clinical Dental Sciences, University of Liverpool, England.
authors.forename: G S
authors.initials: GS
authors.lastname: Ingram
authors.forename: W M
authors.initials: WM
authors.lastname: Edgar
mesh_terms: D000818:Animals; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D002327:Cariostatic Agents / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003731:Dental Caries / Q000188:drug therapy* / Q000378:metabolism; D003743:Dental Enamel / Q000378:metabolism; D003747:Dental Enamel Solubility; D004347:Drug Interactions; D017886:Durapatite / Q000378:metabolism; D005459:Fluorides / Q000493:pharmacokinetics; D006801:Humans; D010710:Phosphates / Q000493:pharmacokinetics; D011122:Polyphosphates / Q000493:pharmacokinetics; D013499:Surface Properties; D014089:Tooth Remineralization; D015032:Zinc / Q000493:pharmacokinetics
chemical_list: D002327:Cariostatic Agents; D010710:Phosphates; D011122:Polyphosphates; C012980:fluorophosphate; D017886:Durapatite; C009293:trimetaphosphoric acid; D015032:Zinc; D005459:Fluorides; D002118:Calcium