[Prognostic factors in bladder cancer].
DNA distribution was studied in tumor cells of 54 patients with bladder cancer. Diploid and aneuploid distributions were recorded in 34 and 20 cases, respectively. Aneuploid DNA proved to be a negative prognostic factor as 5-year survival of such patients made up 48.2%, the lethality rate being 1.78 (p = 0.04). For diploid tumors the above parameters were 80.7% and 0.63, respectively. Poor differentiation of the tumor, invasion in lamina propria, lymphatic and blood vessels occurred much more frequently in patients with aneuploid tumors which appeared to indicate high-grade malignant potential of such tumors. It is concluded that DNA content in bladder cancer is a valuable prognostic criterium. This biological marker requires further studies.
Matveev
B P
BP
Bogatyrev
V N
VN
Ermilova
V D
VD
Figurin
K M
KM
Mustia
A I
AI
Iurasova
I V
IV
Ataev
A A
AA
D000782:Aneuploidy; D001706:Biopsy; D002277:Carcinoma / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D004171:Diploidy; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology
D004273:DNA, Neoplasm
Faktory prognoza pri rake mochevogo puzyria.