Sequence analysis and exclusion of phosducin as the gene for the recessive retinal degeneration of the Abyssinian cat.
Phosducin was evaluated as a candidate gene for the recessive retinal degeneration in the Abyssinan cat, rdAc, using reverse transcription and polymerase chain amplification. The nucleotide sequence of the cat phosducin coding region was determined except for 23 bp at the 5' end. Single-strand conformation analysis of a silent polymorphism within the coding region established the nonlinkage of the phosducin gene with the rdAc locus.
Gorin
M B
MB
Department of Ophthalmology, University of Pittsburgh School of Medicine, PA.
To
A C
AC
Narfstrom
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002415:Cats; D004247:DNA; D005136:Eye Proteins / Q000235:genetics*; D020555:GTP-Binding Protein Regulators; D005808:Genes, Recessive; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011494:Protein Kinases / Q000235:genetics*; D012162:Retinal Degeneration / Q000235:genetics*
D005136:Eye Proteins; D020555:GTP-Binding Protein Regulators; D010750:Phosphoproteins; C065631:phosducin; D004247:DNA; D011494:Protein Kinases