title: Autologous bone marrow transplantation in multiple myeloma: a single centre experience of 23 patients.
abstract: We report the complications and outcome of high-dose melphalan and TBI combined with ABMT used in the treatment of multiple myeloma at a single centre. Twenty-three patients, aged 65 years or less, who underwent the procedure are reviewed. All had chemosensitive disease. Response to ABMT assessed at 3 months showed 75% of evaluable patients to have further tumour cytoreduction of at least 50%, with 24% of patients who entered ABMT with residual disease eventually achieving CR. There was one toxic death. The overall survival is 60% and the progression-free survival is 49.8% at a median follow-up time of 17 months. Relapse or disease progression has occurred in 27% of patients, of whom half have died. No significant prognostic factors affecting survival were found although those patients with IgG myeloma had a better outcome. Patients transplanted in first plateau appeared to do significantly better if they had been resistant to their first-line chemotherapy but had then responded to further conventional chemotherapy (p = 0.029).
authors.affiliation: Department of Haematology, University College Hospital, London, UK.
authors.forename: C D
authors.initials: CD
authors.lastname: Williams
authors.forename: E N
authors.initials: EN
authors.lastname: McSweeney
authors.forename: W
authors.initials: W
authors.lastname: Mills
authors.forename: P
authors.initials: P
authors.lastname: Wells
authors.forename: J D
authors.initials: JD
authors.lastname: Richards
authors.forename: J S
authors.initials: JS
authors.lastname: Tobias
authors.forename: A H
authors.initials: AH
authors.lastname: Goldstone
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003131:Combined Modality Therapy; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D016896:Treatment Outcome; D014916:Whole-Body Irradiation
chemical_list: D008558:Melphalan