title: Intravenous administration of large dosages of adenosine or adenosine triphosphate with minimal blood pressure fluctuation.
abstract: Hemodynamic responses, blood gas, and metabolic changes were assessed when large dosages of a pre-mixed solution of adenosine or adenosine triphosphate (ATP) with catecholamine were intravenously administered in the conscious, spontaneously breathing rabbit. The present study offers a simple and effective approach to enabling safe administration of large doses of the potent vasodilators, adenosine or ATP with minimal cardio-respiratory and metabolic changes.
authors.affiliation: Department of Anesthesiology, Harbor-UCLA Medical Center, Torrance 90509.
authors.forename: A F
authors.initials: AF
authors.lastname: Fukunaga
mesh_terms: D000241:Adenosine / Q000008:administration & dosage* / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects*; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects
chemical_list: D010656:Phenylephrine; D000255:Adenosine Triphosphate; D000241:Adenosine; D008874:Midazolam; D009638:Norepinephrine; D004837:Epinephrine