KB-2796, a calcium channel blocker, ameliorates ischemic spinal cord damage in rabbits.
The effect of the calcium channel blocker (KB-2796) on metabolic and functional recovery in rabbit spinal cord after 20, 30, and 40 min ischemia and 4 days of recovery was investigated. The drug was given intraperitoneally in three different doses, 10, 20, or 50 mg/kg pre- or post-ischemia of 20, 30, or 40 min duration. Both higher doses 20 and 30 mg/kg completely recovered energy state and significantly improved neurological functions in the spinal cord following 20 and 30 min ischemia. Partial protection was observed even after 40 min ischemia. The protective effect of KB-2796 exceeds the effect of calcium blockers previously used in experimental spinal cord ischemia.
Danielisova
V
V
Department of Neurochemistry, Slovak Academy of Sciences, Kosice.
Chavko
M
M
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D007511:Ischemia / Q000188:drug therapy* / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013116:Spinal Cord / Q000098:blood supply*; D013997:Time Factors
D002121:Calcium Channel Blockers; D007773:Lactates; D010879:Piperazines; D019344:Lactic Acid; D000255:Adenosine Triphosphate; C052424:lomerizine; D005947:Glucose