Ethanol induced oxidative stress and membrane injury in rat erythrocytes.
The aim of this study was to observe membrane injury and to investigate the mechanism of antioxidant defence systems against acute ethanol toxicity. Erythrocyte superoxide dismutase and Na+, K(+)-ATPase activities were significantly decreased and catalase levels were significantly increased one hour after ethanol intoxication of male swiss albino rats. These data demonstrated that superoxide dismutase and catalase are susceptible to lipid peroxidation and that these enzymes protect tissues from free radicals. The possible mechanism involved in Na+, K(+)-ATPase and Ca(2+)-ATPase inhibition are discussed in relation to the development of ethanol toxicity and the role of lipid peroxidative processes.
Sözmen
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EY
Ege University School of Medicine, Department of Biochemistry, Bornova-Izmir/Turkey.
Tanyalçin
T
T
Onat
T
T
Kutay
F
F
Erlaçin
S
S
D000435:Alcoholic Intoxication / Q000097:blood* / Q000209:etiology; D000818:Animals; D002374:Catalase / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000201:enzymology; D000431:Ethanol / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D009996:Osmotic Fragility / Q000187:drug effects; D018384:Oxidative Stress; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D008563:Membrane Lipids; D000431:Ethanol; D002374:Catalase; D013482:Superoxide Dismutase; D000254:Sodium-Potassium-Exchanging ATPase