Minocycline-induced hemolytic anemia.
A case of drug-induced immune hemolytic anemia is described. A 2 year old boy exhibited sudden anemia and hemoglobinuria after administration of minocycline (MINO). The specific immunoglobulin G antibody against MINO was demonstrated in the patient's serum by western blotting. This is a rare example where anti-minocycline immune complex-mediated hemolysis was responsible for an intravascular hemolytic process.
Kudoh
T
T
Department of Pediatrics, School of Medicine, Sapporo Medical University, Japan.
Nagata
N
N
Suzuki
N
N
Nakata
S
S
Chiba
S
S
Takahashi
T
T
D000740:Anemia / Q000188:drug therapy*; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D015153:Blotting, Western; D002675:Child, Preschool; D006456:Hemoglobinuria / Q000188:drug therapy*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use*
D007074:Immunoglobulin G; D008911:Minocycline