Anti-Ro/SS-A antibody-positive interstitial pneumonitis in a non-lupus patient.
We describe a 42-year-old anti-Ro/SS-A antibody positive non-lupus patient who developed interstitial pneumonitis in combination with several common clinical features with previously reported lupus pneumonitis patients whose anti-Ro/SS-A antibodies were positive, while whose antinuclear antibodies were negative. We consider that these patients may belong to a same new clinical entity. A variety of characteristic manifestations related to anti-Ro/SS-A antibodies has been reported in patients with systemic lupus erythematosus (SLE) and other connective tissue diseases [1] [2], and an association between these antibodies with pulmonary parenchymal involvement has been reported by Hedgpeth and Boulware in patients with SLE [3] [4]. We report here a 42-year-old non-lupus male patient with pulmonary fibrosis who presented with anti-Ro/SS-A antibodies.
Inoue
T
T
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Okamura
M
M
Negoro
N
N
Konishi
Y
Y
Nishimura
M
M
Umetani
N
N
Takeda
T
T
Inoue
K
K
Kanayama
Y
Y
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies