No effect of a BglI polymorphism at the renin (REN) locus on blood pressure level or variability.
We have studied a normal restriction fragment length polymorphism at the renin locus, detected with the restriction enzyme BglI in healthy Norwegians. No association with blood pressure level or variability was found. Thus, the normal genes detected by examination of this restriction fragment length polymorphism at the renin locus have neither "level gene" nor "variability gene" effects on normal blood pressure.
Berge
K E
KE
Institute of Medical Genetics, University of Oslo, Norway.
Berg
K
K
D000328:Adult; D001794:Blood Pressure / Q000235:genetics*; D016009:Chi-Square Distribution; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009664:Norway; D012150:Polymorphism, Restriction Fragment Length; D012083:Renin / Q000235:genetics*; D014430:Twins, Monozygotic
D015252:Deoxyribonucleases, Type II Site-Specific; C018492:GCCNNNNNGGC-specific type II deoxyribonucleases; D012083:Renin