title: Subcutaneous low doses of recombinant human erythropoietin in predialysis patients do not interfere with the progression of renal failure.
abstract: This paper reports a study on the treatment of predialysis patients with recombinant human erythropoietin (r-HuEPO). The haematocrit, haemoglobin, reticulocyte and platelet values as well as creatinine and creatinine clearance evaluated by standard and radio-isotopic methods before, during and after r-HuEPO treatment were determined. The slope of the inverse creatinine versus time curves was studied too. The authors did not observe any variation of the renal function parameters during and after study and suggest their protocol of r-HuEPO administration for predialysis patients.
authors.affiliation: Chair of Nephrology, School of Medicine, University of Messina, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Savica
authors.forename: G
authors.initials: G
authors.lastname: Costantino
authors.forename: P
authors.initials: P
authors.lastname: Monardo
authors.forename: G
authors.initials: G
authors.lastname: Bellinghieri
mesh_terms: D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D001772:Blood Cell Count; D004921:Erythropoietin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006400:Hematocrit; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D014511:Uremia / Q000097:blood / Q000150:complications* / Q000503:physiopathology
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin