Neuronal cdc2-like kinase.
Neurofilament proteins and the neuron-specific microtubule-associated protein tau are phosphorylated in vivo at sites conforming to the phosphorylation consensus motif of the cell-cycle-control protein kinase, p34cdc2-cyclin. Abnormalities in the phosphorylation of these proteins are associated with neurodegenerative disorders, such as amylotrophic lateral sclerosis and Alzheimer's disease. A cdc2-like kinase composed of cyclin-dependent kinase 5 (cdk5) and a brain-specific regulatory subunit is proposed to be responsible for the cdc2-like phosphorylation of these neuronal proteins.
Lew
J
J
Department of Medical Biochemistry, University of Calgary, Health Sciences Center, Alberta, Canada.
Wang
J H
JH
D000595:Amino Acid Sequence; D000818:Animals; D008969:Molecular Sequence Data; D009474:Neurons / Q000201:enzymology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
D017346:Protein Serine-Threonine Kinases