CD30, Th2 cytokines and HIV infection: a complex and fascinating link.
CD30 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily, and was originally described as a marker of Hodgkin's and Reed-Sternberg cells in Hodgkin's lymphoma. CD30 is preferentially expressed on CD4+ and CD8+ T-cell clones that produce T helper 2 (Th2)-type cytokines, and is also released in a soluble form by these cells. Elevated serum levels of soluble (s)CD30 have been found in some conditions in which a pathogenic role for Th2 cells has been suggested, such as atopy, Omenn's syndrome, systemic lupus erythematosus, as well as following infection with measles virus or human immuno-deficiency virus (HIV). Here, Gianfranco Del Prete and colleagues suggest a complex and fascinating link between the expression and release of CD30, and the immunopathogenesis of HIV infection.
Del Prete
G
G
Division of Clinical Immunology and Allergy, University of Florence, Italy.
Maggi
E
E
Pizzolo
G
G
Romagnani
S
S
D016207:Cytokines / Q000096:biosynthesis*; D015658:HIV Infections / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D017730:Ki-1 Antigen / Q000096:biosynthesis* / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008457:Measles / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines; D017730:Ki-1 Antigen