Confirmation of sulfonamide residues in kidney tissue by liquid chromatography-mass spectrometry.
The development of a method to confirm the presence of sulfonamide residues in kidney tissues at levels at or above the maximum residue limit (MRL, 100 ng g-1 total sulfonamide) using a tandem mass spectrometer [i.e., mass spectrometry-mass spectrometry (MS-MS)] interfaced to a high-performance liquid chromatography is described. Although sulfonamides can be determined using a single quadrupole mass spectrometer with pseudo-MS-MS, advantages in interfacing to a tandem mass spectrometer are demonstrated.
Porter
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Analytical Chemistry Unit, Central Veterinary Laboratory, Addlestone, Surrey, UK.
D000003:Abattoirs; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004350:Drug Residues / Q000032:analysis*; D007668:Kidney / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods; D008460:Meat / Q000032:analysis*; D012680:Sensitivity and Specificity; D013411:Sulfadiazine / Q000032:analysis; D013416:Sulfamerazine / Q000032:analysis; D013418:Sulfamethazine / Q000032:analysis; D013428:Sulfaquinoxaline / Q000032:analysis; D013449:Sulfonamides / Q000032:analysis*; D013552:Swine
D013449:Sulfonamides; D013411:Sulfadiazine; D013418:Sulfamethazine; D013416:Sulfamerazine; D013428:Sulfaquinoxaline