A new genetically engineered vaccine for animal growth promotion.
The chemically synthesized somatostatin (ss) gene was fused in phase with the 3'-end of hepatitis B virus surface antigen (HBsAg) gene. The fusion gene HBs/ss was then recombined into the genome of vaccinia virus. This recombinant virus (vv-HBs/ss) can express hybrid HBsAg/ss particles which present as determinants on their surfaces, thereby bearing a good immunogenicity. This new strategical vaccine of ss can elicit the production of antibody capable of neutralizing ss in the plasma, and consequently enhance the growth of animals.
Xu
W Z
WZ
Department of Veterinary Medicine, Nanjing Agricultural University, PRC.
Du
N X
NX
Li
G D
GD
Wang
Y
Y
Li
Z P
ZP
D000818:Animals; D000906:Antibodies / Q000032:analysis; D003001:Cloning, Molecular; D005814:Genes, Viral; D005818:Genetic Engineering; D016679:Genome, Viral; D006514:Hepatitis B Surface Antigens / Q000235:genetics*; D008297:Male; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000235:genetics* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000096:biosynthesis*; D014616:Vaccinia virus / Q000235:genetics*; D015430:Weight Gain
D000906:Antibodies; D006514:Hepatitis B Surface Antigens; D014614:Vaccines, Synthetic; D013004:Somatostatin