A comparison between the hemolytic and antibacterial activities of new quaternary ammonium polymers.
New quaternary ammonium polymers, which in a previous work had shown relevant antibacterial properties, have been investigated as regards to their hemolytic activity (HA) in comparison with a low molecular weight commercial antibacterial agent, Steramine G (SG). All polymers exhibit negligible, or at most modest, HA at dosages and contact times at which SG is strongly hemolytic.
Marchisio
M A
MA
Istituto di Chirurgia Generale e Cardiovascolare, Milano, Italy.
Bianciardi
P
P
Longo
T
T
Ferruti
P
P
Ranucci
E
E
Neri
M G
MG
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D015394:Molecular Structure; D011108:Polymers / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D000644:Quaternary Ammonium Compounds; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D011108:Polymers; D000644:Quaternary Ammonium Compounds