title: Application of oriented poly-L-lactide screws for experimental Salter-Harris type 4 fracture in distal femoral condyle of the dog.
abstract: The clinical usefulness of biodegradable oriented poly-L-lactide (PLLA) screws for experimental Salter-Harris type 4 fracture in the distal femoral condyle of dogs was evaluated. Bony union of the osteotomized fragment of the condyle was almost completed radiographically and histologically within 1 to 2 months after surgery, suggesting that PLLA screws maintained strength long enough to fix the fragment until bone healing. At 4 to 6 months after surgery, minute fissures were histologically confirmed on the surface of the screw thread, suggesting the early stage of biodegradation and absorption of the polymer. During the observational period, no significant difference between the treated femur and the contralateral non-treated femur in either total femoral length or maximum condyle width was observed, indicating no growth disturbance in the treated femur. From these results it was concluded that the PLLA screw might be an ideal implant for the reduction and fixation of epiphyseal plate fractures such as Salter-Harris type 3 or type 4 fractures.
authors.affiliation: Division of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Tagawa
authors.forename: H
authors.initials: H
authors.lastname: Ejima
authors.forename: H
authors.initials: H
authors.lastname: Orima
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Yamagami
authors.forename: M
authors.initials: M
authors.lastname: Umeda
authors.forename: M
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Shikinami
authors.forename: Y
authors.initials: Y
authors.lastname: Ikada
mesh_terms: D000818:Animals; D001863:Bone Screws / Q000662:veterinary*; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000601:surgery / Q000662:veterinary*; D008297:Male; D011091:Polyesters; D011859:Radiography
chemical_list: D011091:Polyesters; C033616:poly(lactide)