title: Pulpal obliteration related to long-term glucocorticosteroid medication.
abstract: Glucocorticosteroids (GCS) are used in the treatment of chronic autoimmune diseases and many long-term illnesses. While these drugs may be considered essential for the patient's health, adverse reactions do occur. The incidence of adverse reactions depends upon the dose level and the duration of treatment. Three case reports of patients on long-term GCS therapy are presented. Pulpal obliteration was assessed by radiographic records. In all instances, pulpal obliteration to some degree is described; however, the rate and extent of pulpal obliteration in the mature dentition seem greater than those occurring in the immature dentition. In the cases reported, the greatest dentin deposition appeared to occur on the roof of the pulp chamber, indicating that the pattern of dentin deposition by pulp tissue in GCS-treated individuals is different from that of the normal aging process.
authors.affiliation: Department of Dentistry, University of Queensland, Brisbane, Australia.
authors.forename: A L
authors.initials: AL
authors.lastname: Symons
authors.forename: D J
authors.initials: DJ
authors.lastname: Symons
mesh_terms: D000328:Adult; D002648:Child; D003784:Dental Pulp Calcification / Q000139:chemically induced* / Q000000981:diagnostic imaging; D003809:Dentin, Secondary / Q000254:growth & development; D005260:Female; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000009:adverse effects*; D011241:Prednisone / Q000009:adverse effects*; D011859:Radiography
chemical_list: D011239:Prednisolone; D011241:Prednisone