title: Hepatotrophic activity in mouse serum infected with plerocercoids of Spirometra erinacei.
abstract: To investigate the mechanism by which liver weight increases during plerocercoid infections as well as the possible existence of a hepatocyte-growth-factor (HGF)-like substance in the serum of mice infected with Spirometra erinacei plerocercoids, liver DNA synthesis was measured in vivo and in vitro. Infection with S. erinacei plerocercoids significantly stimulated DNA synthesis in mouse parenchymal hepatocytes prior to the increase in liver weight, at least partly by stimulating the induction of the salvage pathways of pyrimidine biosynthesis. Furthermore, infected mouse serum directly stimulated DNA synthesis in cultured mouse parenchymal hepatocytes. These results suggest that an HGF-like substance is present in the serum of mice infected with S. erinacei plerocercoids.
authors.affiliation: Department of Parasitology, Ehime University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuboi
authors.forename: M
authors.initials: M
authors.lastname: Torii
authors.forename: K
authors.initials: K
authors.lastname: Oka
authors.forename: K
authors.initials: K
authors.lastname: Hirai
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002590:Cestode Infections / Q000097:blood* / Q000150:complications / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006529:Hepatomegaly / Q000097:blood / Q000209:etiology / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size; D013146:Spirometra
chemical_list: D017228:Hepatocyte Growth Factor; D004247:DNA