title: Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity.
abstract: Injury to cardiac myocytes often leads to the production of anti-myosin antibodies. While these antibodies are a marker of myocardial injury, their contribution to pathogenesis in diseases such as autoimmune myocarditis or rheumatic fever is much less clear. We demonstrate in this report that monoclonal anti-myosin antibodies can mediate myocarditis in a susceptible mouse strain. Additionally, we show disease susceptibility depends on the presence of myosin or a myosin-like molecule in cardiac extracellular matrix. This study demonstrates that susceptibility to autoimmune heart disease depends not only on the activation of self-reactive lymphocytes but also on genetically determined target organ sensitivity to autoantibodies.
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York 10461.
authors.forename: L
authors.initials: L
authors.lastname: Liao
authors.forename: R
authors.initials: R
authors.lastname: Sindhwani
authors.forename: M
authors.initials: M
authors.lastname: Rojkind
authors.forename: S
authors.initials: S
authors.lastname: Factor
authors.forename: L
authors.initials: L
authors.lastname: Leinwand
authors.forename: B
authors.initials: B
authors.lastname: Diamond
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D016326:Extracellular Matrix Proteins / Q000032:analysis; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D016513:Mice, SCID; D008969:Molecular Sequence Data; D009205:Myocarditis / Q000235:genetics* / Q000276:immunology; D009218:Myosins / Q000276:immunology*; D013045:Species Specificity
chemical_list: D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D016326:Extracellular Matrix Proteins; D007074:Immunoglobulin G; D009218:Myosins