[The patterns of the corrective action of a natural immunomodulator on the secondary immunological defect caused by a corpuscular pertussis vaccine].
Purified staphylococcal toxoid (PST) was shown to be capable of preventing the development of secondary antigen-nonspecific immune deficiency in mice, immunized with whole-cell pertussis vaccine. The immunocorrective action of PST was manifested after its injection before (on day -1), simultaneously with and after (on day +1) the injection of whole-cell pertussis vaccine. Correction was either complete or partial, depending on the scheme of the experiment and the dose of PST.
Semenova
I B
IB
Akatov
A K
AK
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D007274:Injections, Intraperitoneal; D051379:Mice; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013208:Staphylococcal Toxoid / Q000008:administration & dosage*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D010567:Pertussis Vaccine; D013208:Staphylococcal Toxoid
Zakonomernosti korrigiruiushchego deĭstviia prirodnogo immunomoduliatora na vtorichnyĭ immunologicheskiĭ defekt, vyzvannyĭ korpuskuliarnoĭ kokliushnoĭ vaktsinoĭ.