Effect of the sulfonylurea glyburide on glycogen synthase activity in alloxan-induced diabetic rat adipocytes.
1. The effect of glyburide (glibenclamide) treatment in vivo on the adipose tissue glycogen synthase activity of type II diabetic rats has been studied. 2. Three week treatment of diabetic animals with glyburide (5 mg/kg orally, in saline) increased adipose glycogen synthase activity and decreased blood glucose levels. 3. These results demonstrate that the sulfonylurea glyburide is capable of exerting direct insulin-like effect on adipose glycogen-synthase activity of type II diabetic rats in vivo.
Altan
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Department of Biochemistry, Faculty of Medicine, University of Gazi, Beşevler, Ankara, Turkey.
Atalay
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Ongun
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CO
D000273:Adipose Tissue / Q000201:enzymology*; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D006006:Glycogen Synthase / Q000378:metabolism*; D051381:Rats
D001786:Blood Glucose; D000496:Alloxan; D006006:Glycogen Synthase; D005905:Glyburide