Biased (A-->I) hypermutation of animal RNA virus genomes.
RNA genomes evolve largely on the basis of single point mutations introduced by imprecise RNA polymerases, or by recombination. Clusters of certain transitions (biased hypermutations) were detected first in the genomes of persistent viruses, and in the past year have also been found in the genomes of lytic RNA viruses. A cellular RNA-modifying enzyme probably introduces the clustered transitions and thus contributes to the evolution of RNA viruses.
Cattaneo
R
R
Institut für Molekularbiologie I, Universität Zürich, Switzerland.
D000241:Adenosine / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D005075:Biological Evolution; D003641:Deamination; D016679:Genome, Viral; D006801:Humans; D007288:Inosine / Q000378:metabolism; D018096:Mononegavirales / Q000235:genetics / Q000378:metabolism; D017354:Point Mutation; D017393:RNA Editing; D012328:RNA Viruses / Q000235:genetics* / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000096:biosynthesis; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins
D012330:RNA, Double-Stranded; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D007288:Inosine; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase; D000241:Adenosine