title: The ends and the middle: putting chromosomes together.
abstract: The three known classes of eukaryotic telomeres share the requirement for an RNA template in their replication. This RNA-templated replication is subject to species-specific differences, such as telomere length and its regulation, which suggest that telomeres may have acquired different additional functions in different organisms. Centromeres show less conservation than do telomeres.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Pardue
mesh_terms: D000818:Animals; D001483:Base Sequence; D002503:Centromere / Q000235:genetics / Q000502:physiology*; D017124:Conserved Sequence; D004247:DNA / Q000235:genetics; D004253:DNA Nucleotidylexotransferase / Q000378:metabolism; D004261:DNA Replication / Q000502:physiology; D006801:Humans; D018598:Minisatellite Repeats; D008969:Molecular Sequence Data; D010802:Phylogeny; D018626:Retroelements; D016615:Telomere / Q000235:genetics / Q000502:physiology*; D013698:Templates, Genetic
chemical_list: D018626:Retroelements; D004247:DNA; D004253:DNA Nucleotidylexotransferase