Regulation of translation and cell growth by eIF-4E.
This review discusses the regulation of a key controlling step in the initiation of protein synthesis, the binding of mRNA to ribosomes. Particular focus is given to the phosphorylation of the cap-binding factor, eIF-4E, and the role of this factor in the regulation of cell growth.
Sonenberg
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Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
D000818:Animals; D002455:Cell Division / Q000235:genetics*; D039561:Eukaryotic Initiation Factor-4E; D006801:Humans; D010448:Peptide Initiation Factors / Q000502:physiology*; D014176:Protein Biosynthesis
D039561:Eukaryotic Initiation Factor-4E; D010448:Peptide Initiation Factors