title: Antley-Bixler syndrome: report of a patient and review of literature.
abstract: We report a patient with Antley-Bixler syndrome and review 13 patients from the literature. The cardinal features of this condition include craniosynostosis, severe mid-face hypoplasia, proptosis, choanal atresia/stenosis, frontal bossing, dysplastic ears, depressed nasal bridge, radiohumeral synostosis, long-bone fractures and femoral bowing, urogenital abnormalities and a normal karyotype. Early death was identified in 54% of the reported cases, usually due to respiratory complications. The oldest patient at the time of follow up was 10 years of age. Intellectual performance has been variable (developmental testing of our patient at 30 months of age showed a range of developmental skills equivalent to 6 to 11 months of age). Chronic respiratory distress, especially if accompanied by periods of apnea, may be important in the causation of mental retardation. Some patients with the syndrome have normal intelligence, which suggests a normally developing brain, particularly if a craniectomy is performed to treat sutural synostosis and indicates that there may be secondary factors (e.g., apnea) playing a role in the mental retardation (as seen in our patient with a history of apnea) in patients with the Antley-Bixler syndrome. Since choanal atresia/stenosis which diminishes the airway passage is a cardinal feature of this syndrome, choanal stenting should be performed on those patients with this finding during infancy to decrease the airway obstruction. All patients followed beyond infancy were ambulatory, including our patient at 35 months of age, who will take steps with assistance. Although most cases are sporadic, there were reports of recurrence in siblings of both sexes in two families, suggesting an autosomal recessive mode of inheritance.
authors.affiliation: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2578, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hassell
authors.forename: M G
authors.initials: MG
authors.lastname: Butler
mesh_terms: D000015:Abnormalities, Multiple; D000328:Adult; D001003:Anal Canal / Q000002:abnormalities; D002675:Child, Preschool; D004423:Ear / Q000002:abnormalities; D005094:Exophthalmos; D005145:Face / Q000002:abnormalities; D005260:Female; D005264:Femoral Fractures; D005269:Femur / Q000002:abnormalities; D006801:Humans; D008297:Male; D009666:Nose / Q000002:abnormalities; D012886:Skull / Q000002:abnormalities; D013577:Syndrome; D013580:Synostosis