title: [Frequency of genetic polymorphism (Arg353-->Gln) and factor VII levels in Japanese healthy adults].
abstract: We studied factor VII levels and frequency for a G-to-A substitution resulting in the replacement of glutamine for arginine at codon 353 of factor VII by Msp I polymorphism in 101 Japanese healthy adults. An homozygote and seven heterozygotes for the factor VII Gln 353 allele was found in the samples. The frequency of Japanese was not different from those of populations of the United Kingdom, Europe and Afro-Caribbeans, but was different from that in Gurjarati Indians (0.25) previously reported by Humphries et al (Arch Pathol Lab Med 116:1322-1329, 1992). The homozygote had the lowest levels (factor VII activity; 50% and factor VII antigen; 45%) in all samples. The seven heterozygotes had levels of factor VII activity and factor VII antigen about 25% lower than those with only the arginine allele. There were no difference in the levels of factor VII between smoking and no smoking heterozygotes, and between those taking fatty and non-fatty diet.
authors.affiliation: Department of Medical Technology, School of Allied Medical Sciences, Shinshu University, Matsumoto.
authors.forename: O
authors.initials: O
authors.lastname: Takamiya
mesh_terms: D000328:Adult; D001120:Arginine / Q000235:genetics*; D003062:Codon; D005167:Factor VII / Q000235:genetics*; D005260:Female; D005973:Glutamine / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D003062:Codon; D005973:Glutamine; D005167:Factor VII; D001120:Arginine