title: Effects of aerobic exercise training on lymphocyte subpopulations.
abstract: This study was conducted to determine the effects of an aerobic exercise training program on subpopulations of lymphocyte phenotypes. Fourteen healthy but sedentary males, 18-40 years of age, were randomly assigned to either an aerobic exercise training or control condition. Aerobic exercise training consisted of three 45-minute sessions of cycle ergometry exercise per week at 70-80% of age-predicted maximum heart rate for ten weeks. The aerobic exercise training resulted in a significant decrease in submaximal heart rate from 176 to 150 beats per minute to a fixed work rate of 150 watts (p < .01). This training effect was accompanied by increases in the resting level of the following lymphocyte subpopulations: CD2 (1717 vs 2183 mm3; p < .01), CD4 (942 vs 1280 mm3; p < .01), CD45RA+CD4+ (312 vs 595 mm3; p < .01), CD8 (655 vs 816 mm3; p < .05), and CD20 (162 vs 244 mm3; p < .01) cell counts. These findings indicate that several lymphocyte subpopulations are increased following a 10-week program of aerobic exercise training.
authors.affiliation: Department of Psychiatry, University of Miami, Florida.
authors.forename: A
authors.initials: A
authors.lastname: LaPerriere
authors.forename: M H
authors.initials: MH
authors.lastname: Antoni
authors.forename: G
authors.initials: G
authors.lastname: Ironson
authors.forename: A
authors.initials: A
authors.lastname: Perry
authors.forename: P
authors.initials: P
authors.lastname: McCabe
authors.forename: N
authors.initials: N
authors.lastname: Klimas
authors.forename: L
authors.initials: L
authors.lastname: Helder
authors.forename: N
authors.initials: N
authors.lastname: Schneiderman
authors.forename: M A
authors.initials: MA
authors.lastname: Fletcher
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000166:cytology; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D016552:Ergometry; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000166:cytology*; D008297:Male; D010809:Physical Fitness / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology