title: Dynamic contrast-enhanced and fat suppressed magnetic resonance imaging in suspected recurrent carcinoma of the breast: preliminary experience.
abstract: 20 women with suspected recurrent breast cancer who had undergone previous breast-conserving operations were investigated using dynamic contrast-enhanced gradient echo (GRE) and fat suppressed spin echo (SE) magnetic resonance (MR) imaging. Histologically confirmed recurrent tumour was readily recognized on dynamic GRE scans by virtue of rapid, early and avid enhancement. Benign scars enhanced more slowly and reached lower magnitudes of enhancement. Fat suppressed SE images, which were typically acquired 10 min after contrast administration, were sensitive for the detection of tumour recurrence but lacked specificity. Early scanning after contrast administration offers the best prospects for distinguishing tumour recurrence from benign scarring. The criteria used to distinguish these two entities are highly dependent on the scan technique and the time at which images are obtained post-contrast.
authors.affiliation: Centre for Magnetic Resonance Investigations, Hull Royal Infirmary, UK.
authors.forename: R W
authors.initials: RW
authors.lastname: Kerslake
authors.forename: J N
authors.initials: JN
authors.lastname: Fox
authors.forename: P J
authors.initials: PJ
authors.lastname: Carleton
authors.forename: M J
authors.initials: MJ
authors.lastname: Imrie
authors.forename: A M
authors.initials: AM
authors.lastname: Cook
authors.forename: S J
authors.initials: SJ
authors.lastname: Bowsley
authors.forename: A
authors.initials: A
authors.lastname: Horsman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001941:Breast Diseases / Q000175:diagnosis; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008055:Lipids; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D008055:Lipids; D009942:Organometallic Compounds; D013629:Tamoxifen; D004369:Pentetic Acid; D019786:Gadolinium DTPA