title: Differentiation of follicular lymphoma cells after autologous bone marrow transplantation and haematopoietic growth factor treatment.
abstract: A patient with follicular lymphoma developed a striking but transient plasmacytosis in blood and bone marrow with paraproteinaemia after treatment by autologous bone marrow transplantation and interleukin-3 (IL-3). By immunophenotyping, cytogenetics and Southern blotting, we proved that the plasma cells were clonally related to the original lymphoma cells. This event was preceded by fever accompanied by high IL-6 concentrations. The patient recovered spontaneously and had a long-lasting remission. We speculate that the bone marrow-derived malignant B cells were stimulated by IL-3 and IL-6 into terminally differentiated plasma cells.
authors.affiliation: Department of Pathology, University Medical Centre, Leiden, Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: Kramer
authors.forename: P M
authors.initials: PM
authors.lastname: Kluin
authors.forename: E R
authors.initials: ER
authors.lastname: Wijburg
authors.forename: W E
authors.initials: WE
authors.lastname: Fibbe
authors.forename: H C
authors.initials: HC
authors.lastname: Kluin-Nelemans
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007377:Interleukin-3 / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood; D008224:Lymphoma, Follicular / Q000473:pathology* / Q000628:therapy*; D014182:Transplantation, Autologous
chemical_list: D007377:Interleukin-3; D015850:Interleukin-6