Changes in colchicine and demecolcine content during vegetation period of colchicum autumnale L.
Colchicine and demecolcine were determined in raw and dried leaves, stems, mother and daughter corms of Colchicum autumnale L. in four stages of its ontogenesis. The colchicine content in raw material varies during plant growth. The content of both alkaloids decreases with drying. The HPLC method used is suitable both for the phytochemical analysis of Colchicum and for the toxicological evaluation in cases of intoxication by these plants.
Vicar
J
J
Institute of Chemistry, Medical Faculty, Palacký University, Olomouc, Czech Republic.
Klusáková
L
L
Simánek
V
V
D002851:Chromatography, High Pressure Liquid; D003078:Colchicine / Q000378:metabolism*; D003703:Demecolcine / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism*
D003078:Colchicine; D003703:Demecolcine