title: Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat.
abstract: BACKGROUND
  The intestinal barrier properties are impaired during inflammation and sepsis, but the mechanisms behind this are unknown and were therefore investigated during experimental sepsis in rats.
  
  
  METHODS
  The different-sized intestinal absorption markers 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) and ovalbumin were gavaged to rats made septic by intra-abdominal bacterial implantation and to sham-operated rats. Regional tissue permeability was measured in diffusion chambers, and intestinal transit was evaluated by intestinal accumulation of gavaged 51Cr-EDTA.
  
  
  RESULTS
  In comparison with the sham-operated rats, septic rats had higher 51Cr-EDTA levels in blood and urine and showed a prolonged intestinal transit. Septic rats also had a lower tissue permeability to both markers in the small intestines but higher permeability to ovalbumin in the colon. Rats receiving morphine to decrease intestinal motility showed similar changes, with a decreased intestinal transit and increased marker absorption.
  
  
  CONCLUSIONS
  The results suggest that the increased intestinal absorption during sepsis was due to regional permeability changes and prolonged intestinal transit.
authors.affiliation: Dept. of Animal Physiology, Lund University, Sweden.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: N
authors.initials: N
authors.lastname: Pantzar
authors.forename: B
authors.initials: B
authors.lastname: Jeppsson
authors.forename: B R
authors.initials: BR
authors.lastname: Weström
authors.forename: B W
authors.initials: BW
authors.lastname: Karlsson
mesh_terms: D000818:Animals; D001442:Bacteroides Infections / Q000503:physiopathology; D001441:Bacteroides fragilis; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D004927:Escherichia coli Infections / Q000503:physiopathology; D005772:Gastrointestinal Transit; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D010047:Ovalbumin; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000382:microbiology / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D002860:Chromium Radioisotopes; D010047:Ovalbumin; D004492:Edetic Acid