A comparative study of effect of oral chronic cyanide administration on some rabbit tissue ATPases.
The effect of oral KCN administration on Na(+)-K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase activities was studied in some rabbit tissues. Generally, the order of activity of the enzymes was kidney > liver > ileum > colon. There were significant decreases (P < 0.05) in the activities of all the ATPases in the tissues of KCN-treated rabbits relative to controls. The decreases in Na(+)-K(+)-ATPase and Ca(2+)-ATPase activities were most pronounced in liver and kidney. The decreases in ATPases suggest impairment of membrane function as a result of the toxic effect of cyanide.
Okolie
N P
NP
Department of Biochemistry, University of Benin, Nigeria.
Onoagbe
I O
IO
Aisien
F A
FA
D000284:Administration, Oral; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D011190:Potassium Cyanide / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D011190:Potassium Cyanide