Pharmacodynamic and pharmacokinetic interactions between alpha-methylparatyrosine and phenobarbitone.
The hypnosis and hypothermia induced by phenobarbitone (100 mg/kg i.p.) were greatly potentiated by combined treatment with alpha-methylparatyrosine (alpha-MPT, 250 mg/kg i.p.). alpha-MPT per se produced sedation and hypothermia. Measurement of blood and brain levels of phenobarbitone in rats treated with phenobarbitone alone or phenobarbitone plus alpha-MPT revealed that the latter delayed the disappearance rates of phenobarbitone from both brain and plasma. These results suggest an interaction at the site of distribution, metabolism and/or excretion of phenobarbitone. The possibility of a pharmacodynamic interaction involving neurotransmitters is also discussed.
Elhwuegi
A S
AS
Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Al-Fateh Medical University, Tripoli, Libya.
D000818:Animals; D001923:Brain Chemistry; D004347:Drug Interactions; D005260:Female; D006991:Hypnosis, Anesthetic; D007036:Hypothermia, Induced; D008781:Methyltyrosines / Q000493:pharmacokinetics* / Q000494:pharmacology*; D010634:Phenobarbital / Q000493:pharmacokinetics* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors*; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D014446:Tyrosine 3-Monooxygenase; D010634:Phenobarbital