[Fatal vacuolar cardiomyopathy in chronic chloroquine drug treatment].
Clinical and morphological findings recorded in an 81-year-old woman patient with a 45-year history of rheumatoid arthritis treated with long-term chloroquine therapy are reported. The cause of death was low cardiac output syndrome, which upon autopsy and postmortem toxicological analyses was classified as vacuolar chloroquine-induced cardiomyopathy. The pathogenesis and the morphological and clinical characteristics of cardiotoxic effects of chloroquine are reviewed.
Schröder
S
S
Institut für Klinische Pathologie, Universität Zürich.
August
C
C
Pompecki
R
R
Schmoldt
A
A
D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D002303:Cardiac Output, Low / Q000139:chemically induced / Q000473:pathology; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D002738:Chloroquine / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008134:Long-Term Care; D009206:Myocardium / Q000473:pathology; D014617:Vacuoles / Q000187:drug effects* / Q000473:pathology
D002738:Chloroquine
Letale vakuoläre Kardiomyopathie bei chronischer Chloroquin-Medikation.