Phencyclidine-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration.
Phencyclidine (PCP; 2.5 or 5.0 mg/kg) potentiated the effects of rewarding hypothalamic brain stimulation, causing parallel leftward shifts of the functions that relate rate of responding to stimulation frequency. Thus, like a number of other drugs of abuse, PCP lowered the "dose" of stimulation required to maintain responding at a given criterion. No progressive changes in the reward-potentiating effects of PCP were evident when the rats were tested once per week for 8 weeks; there was neither tolerance nor sensitization to the initial rewarding properties of PCP. However, in subsequent locomotor tests rats appeared to be already sensitized to PCP; this raises the possibility that the electrical stimulation of the lateral hypothalamus itself maximally sensitized the animals to the stimulant effects of the drug.
Carlezon
W A
WA
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
Wise
R A
RA
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010622:Phencyclidine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012201:Reward; D012653:Self Stimulation
D010622:Phencyclidine