Effects of streptozotocin-induced diabetes and insulin treatment on blood pressure in the male rat.
Hyperinsulinemia may link diabetes to hypertension. We evaluated the effects of insulin on blood glucose and blood pressure in control and streptozotocin (STZ)-induced (60 mg/kg, i.v.) diabetes. Insulin was given daily for 10-14 weeks to both diabetic (0, 1, 2, and 3 U) and control (0, 2, and 3 U) male rats (n = 7-8/group). Indirect and direct blood pressures were measured as were blood glucose and several metabolic parameters. All treated rats became hyperinsulinemic. Untreated and 1 U insulin-treated diabetic rats were hyperglycemic. Higher doses of insulin significantly reduced blood glucoses in diabetic animals. Indirect blood pressure measurements were unchanged between groups. However, when measured directly, the untreated diabetic rats had significantly lower pressures that did untreated controls. Insulin treatment at dosages above 1 U normalized blood pressure in diabetic animals. These same doses of insulin also restored to normal all the metabolic parameters associated with diabetes. Insulin treatment did not affect any of the parameters evaluated in nondiabetic rats. Collectively, the results show that STZ-induced diabetes results in a decrease in blood pressure and that insulin treatment can restore blood pressure in diabetic rats. Although the results suggest that insulin may be involved in restoring blood pressure in animals with a carbohydrate imbalance, the precise mechanism for elevating blood pressure is not known with certainty.
Katovich
M J
MJ
Department of Pharmacodynamics, University of Florida, Gainesville 32610.
Hanley
K
K
Strubbe
G
G
Wright
B E
BE
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin
D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin