Modulation of acrylamide-induced neurochemical and behavioral deficits by cerebellar transplants in rats.
Acrylamide (30 mg/kg body wt.) administered intraperitoneally daily to young adult male rats, five times a week for 3 consecutive weeks, affected the cerebellar functions, as exhibited by a significant reduction in rotarod performance, spontaneous locomotor activity, glutathione-S-transferase activity, and 3H-flunitrazepam binding in cerebellum. Transplantation of dissociated fetal cerebellar cells (E14) to cerebellum resulted in a significant recovery in behavioral and neurochemical parameters evaluated 9 weeks after transplantation. Light- and electron-microscopic studies confirmed the viability and specificity of cerebellar grafts.
Husain
R
R
Industrial Toxicology Research Centre, Lucknow, India.
Agrawal
A K
AK
Hasan
M
M
Seth
P K
PK
D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D016380:Brain Tissue Transplantation / Q000502:physiology*; D017690:Cell Transplantation / Q000502:physiology*; D002531:Cerebellum / Q000378:metabolism / Q000637:transplantation* / Q000648:ultrastructure; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D005445:Flunitrazepam / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D009043:Motor Activity / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000378:metabolism; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D000178:Acrylamides; D009419:Nerve Tissue Proteins; D005445:Flunitrazepam; D005982:Glutathione Transferase