The effects of local X-irradiation on the distensibility of the rectum in rats.
Proctometry was performed on female Wistar rats following irradiation of the rectum with single doses of 15, 18 and 22 Gy of X-rays. The results indicated a progressive increase in distensibility until week 29 after irradiation which was attributed to degenerative changes in the intestinal wall. A major factor which determines colorectal pressure is the neuromuscular activity, however, neuromuscular transmission was not affected by irradiation.
Tamou
S
S
Department of Radiation Biology, St Bartholomew's Hospital Medical College, London, UK.
Trott
K R
KR
D000818:Animals; D003187:Compliance / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007413:Intestinal Mucosa / Q000473:pathology / Q000528:radiation effects; D008365:Manometry / Q000379:methods; D010528:Peristalsis / Q000528:radiation effects; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012007:Rectum / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects*