title: [Antibacterial activities of a carbapenem antibiotic, biapenem (L-627), against penicillin-resistant Streptococcus pneumoniae].
abstract: Antibiotic susceptibilities were evaluated for 48 strains of Streptococcus pneumoniae collected in 1992-1993 at Ichihara City of Chiba Prefecture. Twenty two (46%) of the 48 strains were benzylpenicillin (PCG) insensitive or resistant (PRSP) judged from the MICs of PCG to higher than 0.1 microgram/ml. MICs of piperacillin and cefotaxime increased as the MICs of PCG increased. However, elevations of MICs of imipenem and biapenem (L-627) were small in spite of the increases of MICs of PCG. L-627 was effective in a case of purulent meningitis due to PC-insensitive S. pneumoniae. Thus, L-627 is a candidate to be used in treatment of PRSP infections including purulent meningitis.
authors.affiliation: Department of Pediatrics, Teikyo University Ichihara Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Meguro
authors.forename: M
authors.initials: M
authors.lastname: Tamura
authors.forename: H
authors.initials: H
authors.lastname: Noguchi
authors.forename: M
authors.initials: M
authors.lastname: Hayakawa
authors.forename: H
authors.initials: H
authors.lastname: Inomata
authors.forename: I
authors.initials: I
authors.lastname: Terashima
authors.forename: T
authors.initials: T
authors.lastname: Kurosaki
authors.forename: T
authors.initials: T
authors.lastname: Toba
mesh_terms: D006801:Humans; D007223:Infant; D008297:Male; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D013845:Thienamycins; C065257:biapenem