title: Bone response to surface modified titanium implants: studies on electropolished implants with different oxide thicknesses and morphology.
abstract: In a series of experimental studies, bone formation was analysed around systematically modified titanium implants. In the present study, machined, electropolished and anodically oxidized implants were prepared, surface characterized and inserted in the cortical bone of rabbits (7 wks and 12 wks). SEM, scanning Auger electron spectroscopy and atomic force microscopy revealed no differences in surface composition but marked differences in oxide thickness, surface topography and roughness. Light microscopic morphology and morphometry showed that all implants were in contact with bone, and had a large proportion of bone within the threads. The smooth, electropolished implants were surrounded by less bone than the machined implants with similar oxide thickness, (4-5 nm) and the anodically oxidized implants with thicker oxides (21 nm and 180 nm, respectively) after 7 wks. These studies show that a high degree of bone contact and bone formation can be achieved with titanium implants which are modified with respect to oxide thickness and surface topography. However, it appears that a reduction of surface roughness may influence the rate of bone formation in rabbit cortical bone.
authors.affiliation: Department of Anatomy and Cell Biology, University of Göteborg, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Larsson
authors.forename: P
authors.initials: P
authors.lastname: Thomsen
authors.forename: J
authors.initials: J
authors.lastname: Lausmaa
authors.forename: M
authors.initials: M
authors.lastname: Rodahl
authors.forename: B
authors.initials: B
authors.lastname: Kasemo
authors.forename: L E
authors.initials: LE
authors.lastname: Ericson
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001846:Bone Development / Q000187:drug effects; D005260:Female; D008297:Male; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000737:chemistry* / Q000633:toxicity; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D013977:Tibia / Q000187:drug effects / Q000502:physiology*; D014025:Titanium / Q000737:chemistry* / Q000633:toxicity
chemical_list: D010087:Oxides; C009495:titanium dioxide; D014025:Titanium