Central action of glaucine in rodents.
It was found that glaucine (7, 14 and 28 mg/kg ip) decreased locomotor activity, did not affect the body temperature and potentiated the amphetamine and apomorphine stereotypy but did not affect the amphetamine hypermotility. Besides, glaucine antagonized haloperidol-induced catalepsy of the rats. Glaucine was without analgesic, anticonvulsant, antianxiety and antidepressive effects in mice. This alkaloid in doses of 14 and 28mg/kg ip antagonized the head twitch response induced by 5-HTP in the rats. Further, glaucine decreased the hyperthermia induced by m-CPP in rats kept at high ambient temperature. It was found that glaucine depressed the noradrenaline (NA) and dopamine (DA) levels in the whole brain of mice. Besides, this alkaloid significantly decreased the brain level of 5-hydroxytryptamine (5-HT), without changing the 5-hydroxyindoleacetic acid (5-HIAA) concentration.
Jagiełło-Wójtowicz
E
E
Department of Pharmacology, School of Medicine, Lublin, Poland.
Kleinrok
Z
Z
Jusiak
L
L
Matuszek
B
B
Daniłoś
J
J
Chodakowska
A
A
D000818:Animals; D001060:Aporphines / Q000494:pharmacology* / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects
D001060:Aporphines; C005004:glaucine