Reduced size liver transplantation, split liver transplantation, and living related liver transplantation in relation to the donor organ shortage.
Because of the shortage of cadaveric donors, three techniques of partial liver grafting have been developed. These techniques are placed in perspective in relation to the organ shortage. Reduced size liver transplantation (RSLTx) is widely used and has results comparable to those from whole liver grafting. However, this technique, while benefitting pediatric patients, reduces the adult donor liver pool. It also makes inefficient use of an available adult donor liver. In split liver transplantation (SPLTx), the whole liver is used after bipartition for two recipients. The results are comparable to those of RSLTx. The problem with SPLTx is that it is a very demanding technique applied only in centers with extensive experience with liver resection and reduction. Living related liver transplantation (LRLTx) yields excellent results; however, it places an otherwise healthy person at risk. It is argued that instead of performing risky operations on healthy persons, the health authorities should take specific measures to alleviate the organ shortage. In the meantime, SPLTx should be developed further because of its optimal use of donor tissue. As for LRLTx, its excellent results and the present shortage of size-matched pediatric liver donors justify its use, at least for now.
Slooff
M J
MJ
Department of Surgery, University Hospital Groningen, The Netherlands.
D000328:Adult; D002675:Child, Preschool; D006085:Graft Survival; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D016019:Survival Analysis; D014019:Tissue Donors / Q000600:supply & distribution; D009927:Tissue and Organ Procurement