title: Comparison of topical fibrin glue, fibrinogen, and thrombin in preventing seroma formation in a rat model.
abstract: Fibrin glue has been shown to decrease seroma formation in animal models. To further delineate this mechanism, the efficacy of fibrin glue was compared to topical fibrinogen and thrombin in preventing postoperative seromas. A model consistently producing seromas was developed by bilateral neck dissection, lymphadenectomy, and submandibular sialoadenectomy in the Sprague-Dawley rat. Groups of 20 rats underwent this procedure and were blindly treated with either fibrin glue, fibrinogen, thrombin, or saline control. Necropsy on postoperative day 5 revealed a statistically significant (chi-squared) decrease in seroma incidence using fibrin glue (0%) and fibrinogen (15%), while thrombin (95%) and saline (100%) were ineffective in preventing seromas. The use of fibrin glue and fibrinogen in this role merits further investigation.
authors.affiliation: Department of Otolaryngology--Head and Neck Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
authors.forename: W H
authors.initials: WH
authors.lastname: Lindsey
authors.forename: D G
authors.initials: DG
authors.lastname: Becker
authors.forename: J R
authors.initials: JR
authors.lastname: Hoare
authors.forename: R W
authors.initials: RW
authors.lastname: Cantrell
authors.forename: R F
authors.initials: RF
authors.lastname: Morgan
mesh_terms: D000818:Animals; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D005340:Fibrinogen / Q000008:administration & dosage*; D008297:Male; D037981:Neck Dissection; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013363:Submandibular Gland / Q000601:surgery; D013524:Surgical Flaps; D013917:Thrombin / Q000008:administration & dosage*; D014945:Wound Healing
chemical_list: D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D013917:Thrombin