Cardiac function and histological changes after non-dynamic cardiomyoplasty and preliminary study of dynamic cardiomyoplasty.
By means of histological method and ultrasound cardiographic (UCG) examination, the left-right ratio of transectional area of muscle fiber of latissimus dorsi muscle (LDM) after non-dynamic cardiomyoplasty was 77.4 +/- 11.7% in Group I (3 weeks after operation), and 78.4 +/- 11.6% atrophy and hyperplasia of LDM, but the basical structure was retained. The ejection fraction (EF) decreased significantly after operation (P < 0.05), but the difference between two groups was non- significant. Also, dynamic cardiomyoplasty was performed on a sheep. UCG showed the increased cardiac systolic function after operation. ATPase, succinodehydrogenase (SDH) and PAS examination implied the strengthening of fatigue-resistant ability in skeletal muscles after long-term electrical stimulation. So cardiomyoplasty is suggested to be a supplementary measure in treating end-stage heart failure.
Ma
Y G
YG
Research Center of Plastic Surgery, 3rd School of Clinical Medicine, Beijing Medical University.
Wang
D M
DM
Li
J N
JN
Zhu
H Y
HY
D000818:Animals; D018421:Cardiomyoplasty; D004285:Dogs; D004452:Echocardiography; D006321:Heart / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology; D012756:Sheep; D016277:Ventricular Function, Left / Q000502:physiology