title: SECReT of the eukaryotic large ribosomal subunit.
abstract: The large ribosomal subunit of the thermophilic fungus Thermomyces lanuginosus was reconstructed in three dimensions from electron micrographs. This is the first reported reconstruction of the eukaryotic complex and demonstrates specific structural features such as an intersubunit canyon and a potential channel for the nascent peptide chain.
authors.affiliation: Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Harauz
authors.forename: H
authors.initials: H
authors.lastname: Zuzan
authors.forename: P T
authors.initials: PT
authors.lastname: Kim
authors.forename: J A
authors.initials: JA
authors.lastname: Holbrook
mesh_terms: D000465:Algorithms; D006358:Hot Temperature; D008854:Microscopy, Electron / Q000379:methods; D003904:Mitosporic Fungi / Q000648:ultrastructure*; D008961:Models, Structural; D012270:Ribosomes / Q000648:ultrastructure*