[Magnetic resonance tomography of finger polyarthritis: morphology and cartilage signals after ademetionine therapy].
This report deals with a prospective study of 21 patients with finger osteoarthritis treated over a period of three months with either Ademetionin (therapy group: 14/21) or without (control group: 7/21). MR-Imaging was carried out before and after treatment using spin-echo and 3D-Flash sequences. Morphological parameters and signal intensity changes of the hyaline cartilage were evaluated. The increase of the cartilage signal intensity was significant in the therapy group, this can be interpreted as an structural improvement. Also a decrease of the cartilage signal intensity with age was found. The morphological parameters showed no significant changes in the therapy and control groups.
König
H
H
Abteilung für Röntgendiagnostik und Nuklearmedizin, Univ.-Klinikum Steglitz der FU Berlin.
Stahl
H
H
Sieper
J
J
Wolf
K J
KJ
D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy*; D002358:Cartilage, Articular / Q000187:drug effects* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005384:Finger Joint / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008875:Middle Aged; D011446:Prospective Studies; D012436:S-Adenosylmethionine / Q000627:therapeutic use*
D012436:S-Adenosylmethionine
Magnetresonanztomographie der Fingerpolyarthrose: Morphologie und Knorpelsignalverhalten unter Ademetonintherapie.