In vitro activity of biapenem against beta-lactamase producing Enterobacteriaceae.
The activity of biapenem was compared with that of imipenem and cefotaxime against 108 strains of beta-lactamase producing Enterobacteriaceae. Biapenem and imipenem were very active, inhibiting 90% of the strains at a concentration of 0.5 microgram/ml. Both carbapenems were very active against plasmidic beta-lactamase producers, with MIC90s below 1 microgram/ml. However, the MIC90 of biapenem for cephalosporinase producers was 1 microgram/ml. Against strains producing extended-spectrum beta-lactamases, biapenem exhibited better activity against TEM-type producers (MIC90 0.25 microgram/ml) than against SHV-type producers (MIC90 0.5 microgram/ml). Overall, the in vitro antibacterial activity of biapenem is similar to that of imipenem.
Alonso
R
R
Department of Microbiology, School of Medicine, University of Basque Country, Bilbao, Spain.
Fernández-Aranguiz
A
A
Colom
K
K
Morla
A
A
Suinaga
E
E
Umaran
A
A
Cisterna
R
R
D002439:Cefotaxime / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012680:Sensitivity and Specificity; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000096:biosynthesis
D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; D002439:Cefotaxime; C065257:biapenem