A fatal case of buflomedil self-poisoning: toxicological data and literature review.
A fatal case of buflomedil (Fonzylane) self-poisoning is presented. Drug identification and quantification in postmortem blood, urine and gastric contents was achieved by means of high pressure liquid chromatography with diode-array detection (HPLC/DAD). Blood concentration was 275 micrograms/ml, > 70 times the usual therapeutic values. Toxicological results are discussed in the light of the existing literature.
Tracqui
A
A
Institut de Médecine Légale, Strasbourg, France.
Deveaux
M
M
Kintz
P
P
Mangin
P
P
Gosset
D
D
D000317:Adrenergic alpha-Antagonists / Q000493:pharmacokinetics / Q000506:poisoning*; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003866:Depressive Disorder / Q000097:blood / Q000473:pathology; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D008297:Male; D011180:Postmortem Changes; D011759:Pyrrolidines / Q000493:pharmacokinetics / Q000506:poisoning*; D013405:Suicide / Q000331:legislation & jurisprudence*
D000317:Adrenergic alpha-Antagonists; D011759:Pyrrolidines; C010651:buflomedil