title: Pleomorphic xanthoastrocytoma and desmoplastic infantile ganglioglioma--have these neoplasms a common origin?
abstract: We report a case of a 24-year-old woman with left temporal pleomorphic xanthoastrocytoma (PXA) with atypical neuronal cells. Many neoplastic cells, otherwise typical of PXA, expressed glial fibrillary acidic protein, while neuronal cells with marked atypia were immunopositive for synaptophysin and neurofilament protein. This report supports a notion that PXA, like other astrocytic tumors, may has its gangliogliomatous counterpart as superficial cerebral astrocytoma of infancy has it in desmoplastic infantile ganglioglioma.
authors.affiliation: Department of Cancer Pathology, School of Medicine, Lódź.
authors.forename: R
authors.initials: R
authors.lastname: Kordek
authors.forename: W
authors.initials: W
authors.lastname: Biernat
authors.forename: J
authors.initials: J
authors.lastname: Alwasiak
authors.forename: P P
authors.initials: PP
authors.lastname: Liberski
mesh_terms: D000328:Adult; D001253:Astrocytes / Q000648:ultrastructure; D001254:Astrocytoma / Q000473:pathology* / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D002648:Child; D005260:Female; D018303:Ganglioglioma / Q000473:pathology* / Q000648:ultrastructure; D005904:Glial Fibrillary Acidic Protein; D006801:Humans; D010296:Parietal Lobe / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D005904:Glial Fibrillary Acidic Protein