Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder.
Schedule-induced polydipsia was used to determine the effects of selective serotonin re-uptake inhibitors on adjunctive water consumption. Polydipsia was induced in food deprived rats by exposure to a fixed time feeding schedule (FT = 60 s) for 150 min per day for 22 days. Selected polydipsic rats consumed 3-4 times greater volume of water compared to food deprived control rats. Chronic administration of the selective serotonin re-uptake inhibitors fluoxetine and clomipramine (CMI) at 5 mg/kg per day and fluvoxamine at 10 mg/kg twice a day significantly decreased schedule-induced polydipsia (SIP) on day 15 and throughout the remainder of the study compared to control rats. The noradrenergic re-uptake inhibitor, desipramine (DMI), only decreased SIP behavior on day 1. The neuroleptic, haloperidol (0.03 and 0.1 mg/kg), and the benzodiazepine, diazepam (2.5 mg/kg), failed to alter SIP behavior. Since obsessive-compulsive disorder (OCD) and polydipsic behavior both involve excessive expression of a normal behavior, the polydipsia model may be relevant for the prediction of compounds useful in the treatment of OCD.
Woods
A
A
Department of Biological Research, Hoechst-Roussel Pharmaceuticals, Inc. Somerville, NJ 08876.
Smith
C
C
Szewczak
M
M
Dunn
R W
RW
Cornfeldt
M
M
Corbett
R
R
D000818:Animals; D002997:Clomipramine / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D003891:Desipramine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004195:Disease Models, Animal; D004327:Drinking Behavior / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D012055:Reinforcement Schedule; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D002997:Clomipramine; D003891:Desipramine; D003975:Diazepam; D005473:Fluoxetine; D006220:Haloperidol; D017367:Selective Serotonin Reuptake Inhibitors