Effect of gabexate mesilate on thrombin and plasmin generation after hepatic resection in cirrhotic patients.
The effect of the gabexate mesilate (Gab) on thrombin and plasmin generation following liver resection in cirrhotic patients was studied. Six cirrhotic patients received an infusion of Gab after liver resection (Gab group), and another 6 patients did not receive such treatment (Con group). The parameters measured were thrombin-antithrombin complex (TAT), plasmin-antiplasmin complex (PAP) and D-dimer. The real increases of D-dimer and PAP were significantly higher in Con group after surgery while no significant difference was observed in the increase of TAT. These results show that Gab suppresses plasmin generation and following D-dimer production more effectively than thrombin generation after hepatic resection.
Wada
Y
Y
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Zaima
M
M
Mori
K
K
Egawa
H
H
Higashiyama
H
H
Iwata
S
S
Kagawa
R
R
Kataoka
M
M
Ozawa
K
K
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000601:surgery; D005260:Female; D005341:Fibrinolysin / Q000096:biosynthesis* / Q000187:drug effects; D016670:Gabexate / Q000627:therapeutic use*; D006498:Hepatectomy; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism / Q000601:surgery*; D008113:Liver Neoplasms / Q000378:metabolism / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013917:Thrombin / Q000096:biosynthesis* / Q000187:drug effects
D016670:Gabexate; D013917:Thrombin; D005341:Fibrinolysin