title: Allergic contact dermatitis from the synthetic fragrances Lyral and acetyl cedrene in separate underarm deodorant preparations.
abstract: The case is reported of a 28-year-old man who developed allergic contact dermatitis from 2 synthetic fragrance ingredients, Lyral (3- and 4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-aldehyde) and acetyl cedrene, in separate underarm deodorant preparations. The implications of the patient's negative patch test reactions to the European standard series (Trolab) and cosmetics and fragrance series (both Chemotechnique Diagnostics) are discussed. The importance is stressed of patch testing with the patient's own preparations when cosmetic dermatitis is suspected, and of identifying and reporting offending fragrance ingredients, with a view possibly to updating the European standard series and commercially available cosmetics and fragrance series.
authors.affiliation: Department of Dermatology, Royal Victoria Hospital, Belfast, N. Ireland, UK.
authors.forename: J
authors.initials: J
authors.lastname: Handley
authors.forename: D
authors.initials: D
authors.lastname: Burrows
mesh_terms: D000328:Adult; D000447:Aldehydes / Q000009:adverse effects*; D001365:Axilla; D053138:Cyclohexenes; D003836:Deodorants / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D007659:Ketones / Q000009:adverse effects; D008297:Male; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*; D012717:Sesquiterpenes; D013729:Terpenes / Q000009:adverse effects*
chemical_list: D000447:Aldehydes; D053138:Cyclohexenes; D003836:Deodorants; D007659:Ketones; D010476:Perfume; D012717:Sesquiterpenes; D013729:Terpenes; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde; C092242:acetyl cedrene