Alterations in TRH receptors in temporal lobe of schizophrenics: a quantitative autoradiographic study.
We utilized quantitative autoradiography to determine the distribution of receptors for thyrotropin-releasing hormone (TRH) throughout the human temporal lobe and to examine the distribution of these receptors in discrete subregions of the temporal lobe from patients diagnosed premortem with schizophrenia. When compared to non-neurologic controls, schizophrenic patients demonstrated an increase of 51% in the concentration of TRH receptors in the molecular layer of the dentate gyrus. Within nuclei of the schizophrenic amygdala, marked decreases were found in the central (44%), medial (38%), cortical (36%), accessory cortical (52%), lateral (54%), and medial basal (22%) nuclei. We also examined postmortem brain samples from patients with Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease for alterations in the distribution of TRH receptors. No significant differences from non-neuropsychiatric controls were noted within the hippocampus in any of these disease states; however, slight alterations were noted in the central and medial basal amygdala in Huntington's disease and in the cortical amygdala in Alzheimer's disease. These disease-specific findings suggest that TRH may play a role in the neurochemical dysfunction of schizophrenia.
Lexow
N
N
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104.
Joyce
J N
JN
Kim
S J
SJ
Phillips
J
J
Casanova
M F
MF
Bird
E D
ED
Kleinman
J E
JE
Winokur
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism; D000679:Amygdala / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D001345:Autoradiography; D003720:Densitometry; D018728:Entorhinal Cortex / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018025:Receptors, Thyrotropin-Releasing Hormone / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*
D018025:Receptors, Thyrotropin-Releasing Hormone