title: Minocycline-induced hemolytic anemia.
abstract: A case of drug-induced immune hemolytic anemia is described. A 2 year old boy exhibited sudden anemia and hemoglobinuria after administration of minocycline (MINO). The specific immunoglobulin G antibody against MINO was demonstrated in the patient's serum by western blotting. This is a rare example where anti-minocycline immune complex-mediated hemolysis was responsible for an intravascular hemolytic process.
authors.affiliation: Department of Pediatrics, School of Medicine, Sapporo Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kudoh
authors.forename: N
authors.initials: N
authors.lastname: Nagata
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Nakata
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000740:Anemia / Q000188:drug therapy*; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D015153:Blotting, Western; D002675:Child, Preschool; D006456:Hemoglobinuria / Q000188:drug therapy*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use*
chemical_list: D007074:Immunoglobulin G; D008911:Minocycline