Ten-year course of schizophrenia--the Madras longitudinal study.
Ninety first-episode patients fulfilling ICD-9 criteria for schizophrenia were followed up prospectively for 10 years. Complete assessments were possible on 76. The pattern of illness was good in 67% of the cases, and the commonest patterns was one with recurrent episodes. Predictors of poor course and longer time spent in psychosis were identified. All positive and negative symptoms showed a steep decline at the end of 10 years. The results are discussed in the context of longitudinal research on the course of schizophrenia in developing countries.
Thara
R
R
Schizophrenia Research Foundation, Madras, India.
Henrietta
M
M
Joseph
A
A
Rajkumar
S
S
Eaton
W W
WW
D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects / Q000627:therapeutic use; D015331:Cohort Studies; D003906:Developing Countries; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007194:India; D008137:Longitudinal Studies; D008297:Male; D010343:Patient Admission; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000534:rehabilitation; D012565:Schizophrenic Psychology; D016896:Treatment Outcome; D014268:Trifluoperazine / Q000009:adverse effects / Q000627:therapeutic use; D014505:Urban Population
D014268:Trifluoperazine; D006220:Haloperidol; D002746:Chlorpromazine