title: Cold-induced changes in brown adipose tissue thermogenic capacity of immunocompetent and immunodeficient hairless mice.
abstract: Mild cold acclimation (22 degrees C, 3 weeks) of hairless mice was shown to increase 5-fold the brown adipose tissue uncoupling protein content in immunodeficient BALB/c nu/nu mice, but by only 2.3-fold in immunocompetent BFU mice. The difference in activation of brown adipose tissue thermogenic capacity was due to a 2-fold increase in the content of brown adipose tissue in nu/nu mice only, which was paralleled by an increase in brown adipose tissue protein but not DNA content. Likewise, only in nu/nu mice the cold acclimation increased the reaction of natural killer cells in blood and peritoneal exudate with a shift from spleen to lymph nodes and increased the phagocytic index. The results indicate that the immune system may influence the defence against cold at the level of brown adipose tissue thermogenesis.
authors.affiliation: Institute of Physiology, Academy of Sciences, Czech Republic, Prague.
authors.forename: J
authors.initials: J
authors.lastname: Houstĕk
authors.forename: M
authors.initials: M
authors.lastname: Holub
mesh_terms: D000064:Acclimatization; D002001:Adipose Tissue, Brown / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D003080:Cold Temperature; D007154:Immune System Diseases / Q000503:physiopathology*; D007121:Immunocompetence; D007694:Killer Cells, Natural / Q000502:physiology; D051379:Mice; D008812:Mice, Hairless / Q000502:physiology*; D008807:Mice, Inbred BALB C; D010587:Phagocytosis