Protecting effect of taurine against hypoxic cell damage in renal tubular cells cultured in different transplant preservation solutions.
We conclude that, within this experimental model and under these experimental conditions, taurine supplementation of standard kidney preservation solutions improves survival of kidney cells during hypoxic preservation. The protective effect depends on the taurine concentration, the hypoxic preservation time and the used preservation solution. Physiological taurine concentrations are effective during short hypoxic periods, whereas pharmacological taurine concentrations seem to be needed for longer periods of hypoxia. Within this experimental model University of Wisconsin solution seems to be more effective than Euro collins solution.
Wingenfeld
P
P
Department of Pediatrics, University of Cologne, Federal Republic of Germany.
Strübind
S
S
Gehrmann
U
U
Minor
T
T
Isselhard
W
W
Michalk
D
D
D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects*; D002460:Cell Line; D007687:Kidney Tubules, Proximal / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D016377:Organ Transplantation; D012996:Solutions; D013552:Swine; D013654:Taurine / Q000494:pharmacology*; D014021:Tissue Preservation
D012996:Solutions; D013654:Taurine