title: Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene.
abstract: We have identified the rum1+ gene as a new regulator of the G1-phase of the fission yeast cell cycle. rum1+ determines the cell cycle timing of Start, by maintaining cells in a pre-Start state until they have attained a minimal critical mass. Cells lacking rum1+ are unable to arrest in pre-Start G1 in response to nitrogen starvation and are subsequently sterile. In addition, rum1+ prevents entry into mitosis from pre-Start G1, as shown by the fact that cdc10 mutants in the absence of rum1+ undergo lethal mitosis without entering S-phase.
authors.affiliation: Instituto de Microbiología Bioquímica, CSIC/Universidad de Salamanca, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Moreno
authors.forename: K
authors.initials: K
authors.lastname: Labib
authors.forename: J
authors.initials: J
authors.lastname: Correa
authors.forename: P
authors.initials: P
authors.lastname: Nurse
mesh_terms: D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics; D004261:DNA Replication / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics* / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal / Q000235:genetics; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins; D017384:Sequence Deletion / Q000502:physiology; D013696:Temperature; D014157:Transcription Factors / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; D005656:Fungal Proteins; C086077:Rum1 protein, S pombe; D029702:Schizosaccharomyces pombe Proteins; D014157:Transcription Factors; C061178:cdc10 protein, S pombe