Suppression by kampo medicine, sho-saiko-to, on papillomas induced by 7,12-dimethylbenz(a)anthracene in mice.
Sho-saiko-to (SST) is a Japanese modified, traditional Chinese herbal medicine (Kampo medicine) consisting of seven medical plants. We examined the effects of SST on formation and growth of squamous cell papillomas induced by 7,12-dimethylbenz(a)anthracene application in mouse skin. Chronic oral administration of SST reduced the incidence and growth of papillomas with the reduction of activities of succinate-dehydrogenase and thymidylate synthetase, which were evaluated as the cell viability and DNA synthesis via the de novo pathway, respectively.
Liu
L
L
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Sakamoto
S
S
Nakayama
T
T
Kudo
H
H
Suzuki
S
S
Matsubara
M
M
Nagasawa
H
H
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D015127:9,10-Dimethyl-1,2-benzanthracene; D013385:Succinate Dehydrogenase