title: Dysmorphic erythrocytes in glomerulonephritis. 1. Electron microscopical and histochemical investigation.
abstract: Dysmorphic erythrocyte malformation in urine is characteristic of glomerulonephritis. The mechanisms leading to this phenomenon are still unknown. To obtain evidence of the site as well as of the process of erythrocyte damage, electron microscopical and histochemical investigations of renal biopsy materials from 19 patients with histologically defined glomerulonephritis were performed. The results suggest that the initial damage of erythrocytes in the glomerular area is reasoned by enzymatic glycocalyx destruction. On passage through the tubular system the osmotically sensitized surface altered cells undergo rapid hemolysis and losses of membrane skeletal proteins leading to dysmorphic shape transformations.
authors.affiliation: Institute of Anatomy I, Friedrich Schiller University, Jena, Federal Republic of Germany.
authors.forename: R
authors.initials: R
authors.lastname: Fünfstück
authors.forename: K J
authors.initials: KJ
authors.lastname: Halbhuber
authors.forename: B
authors.initials: B
authors.lastname: Kühn
authors.forename: R
authors.initials: R
authors.lastname: Kühn
authors.forename: H
authors.initials: H
authors.lastname: Oehring
authors.forename: C
authors.initials: C
authors.lastname: Scheven
authors.forename: W
authors.initials: W
authors.lastname: Linss
authors.forename: G
authors.initials: G
authors.lastname: Stein
mesh_terms: D000328:Adult; D001706:Biopsy; D003404:Creatinine / Q000652:urine; D003720:Densitometry; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes; D004913:Erythrocytes, Abnormal / Q000737:chemistry / Q000473:pathology*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood* / Q000473:pathology; D006456:Hemoglobinuria / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D008854:Microscopy, Electron; D008875:Middle Aged; D011507:Proteinuria / Q000473:pathology; D017452:Receptors, IgG / Q000032:analysis
chemical_list: D008562:Membrane Glycoproteins; D017452:Receptors, IgG; D003404:Creatinine