In vivo evaluation of the Hydrolyser hydrodynamic thrombectomy catheter.
OBJECTIVE
The authors evaluated a 7-F double-lumen thrombectomy catheter (Hydrolyser) in vivo.


METHODS
To evaluate efficacy, thrombectomy was performed 1, 4, or 8 days after local denudation in peripheral arteries (n = 18) and veins (n = 29) of nine goats. To evaluate safety, the reaction of the vessel wall to a functioning and nonfunctioning Hydrolyser catheter was evaluated in the peripheral arteries and veins of three goats 10 days after the procedure.


RESULTS
Reopening was achieved in all vessels with residual thrombus in 11% of arteries (two of 18) and 55% of veins (16 of 29). Slight intimal thickening was observed, but no difference was seen between the passage of a functioning versus nonfunctioning catheter.


CONCLUSIONS
The Hydrolyser device can remove intravascular thrombus up to 8 days after induction. There was no difference in vessel wall reaction after the passage of a functioning and nonfunctioning catheter.
van Ommen
V
V
Department of Cardiology, Academic Hospital Maastricht, University of Limburg, The Netherlands.
van der Veen
F H
FH
Daemen
M J
MJ
Habets
J
J
Wellens
H J
HJ
D000818:Animals; D002406:Catheterization, Peripheral / Q000009:adverse effects / Q000295:instrumentation*; D005069:Evaluation Studies as Topic; D005263:Femoral Artery; D005268:Femoral Vein; D006041:Goats; D013927:Thrombosis / Q000628:therapy*