Adrenomedullary function in depressed patients.
In this paper from the Collaborative Depression Study (CDS)--Biological, a set of data analyses are presented which indicate that depressed states and perhaps depressed mood are associated with a greater activation of the adrenomedullary system than the sympathetic nervous system [as measured by norepinephrine (NE) and normetanephrine excretion]. For the most part this finding of predominant activation of the adrenomedullary system is seen in unipolar and not bipolar patients.
Maas
J W
JW
Department of Psychiatry, University of Texas Health Science Center at San Antonio 78284-7792.
Katz
M M
MM
Koslow
S H
SH
Swann
A
A
Davis
J M
JM
Berman
N
N
Bowden
C L
CL
Stokes
P E
PE
Landis
H
H
D000313:Adrenal Medulla / Q000503:physiopathology*; D000639:Amitriptyline / Q000008:administration & dosage / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000652:urine; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use; D013564:Sympathetic Nervous System / Q000503:physiopathology
D000639:Amitriptyline; D007099:Imipramine