title: Quantitative analysis of a drug in an animal feed employing sample preparation by supercritical fluid extraction.
abstract: A pharmaceutical agent has been quantified in a rat feed matrix wherein sample preparation was achieved by supercritical fluid extraction. Spiking levels ranged from 0.0335% to 1.12%. Pure carbon dioxide, solid phase trapping on stainless steel with acetonitrile and liquid chromatographic assay yielded recoveries greater than 90% with relative standard deviations less than 5% in all cases except for the lowest spiking level. In this case recovery was 89.6% with an RSD of 9.6.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061.
authors.forename: D C
authors.initials: DC
authors.lastname: Messer
authors.forename: L T
authors.initials: LT
authors.lastname: Taylor
authors.forename: W E
authors.initials: WE
authors.lastname: Weiser
authors.forename: J W
authors.initials: JW
authors.lastname: McRae
authors.forename: C C
authors.initials: CC
authors.lastname: Cook
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D053626:Atovaquone; D002853:Chromatography, Liquid; D015394:Molecular Structure; D009285:Naphthoquinones / Q000302:isolation & purification*; D051381:Rats; D015203:Reproducibility of Results
chemical_list: D009285:Naphthoquinones; D053626:Atovaquone