Recovery of muscular energy status in chronic alcoholics after 2 weeks of abstinence.
Repeated and excessive consumption of alcohol leads to pathophysiological disorders in skeletal muscles. A successful management of this syndrome requires a strict abstinence and a nutritionally adequate diet. We propose here a simple and noninvasive investigation using 31P magnetic resonance spectroscopy (MRS) to monitor the recovery of the basal energy status of eminence thenar muscles from documented chronic alcoholic patients during a controlled 15-day period of abstinence. Cessation of alcohol abuse induced a significant recovery of the PCr/(PCr+P(i)) ratio otherwise depressed before the abstinence. On the contrary, the relative level of free inorganic phosphate decreased, whereas intracellular pH was not affected. These results demonstrate (a) the rapid improvement of basal muscular energy metabolism during abstinence for patients with a chronic and heavy alcohol consumption, and (b) the feasibility of a follow-up of this recovery by serial examinations using 31P MRS.
Masson
S
S
NMR Research Laboratory, IRCCS H. San Raffaele, Milan, Italy.
Baldassarri
A M
AM
Ceroni
M
M
Savoldi
F
F
Villa
M
M
Boicelli
A
A
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000378:metabolism*; D004734:Energy Metabolism; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism
D010710:Phosphates; D010725:Phosphocreatine; D000431:Ethanol