Effects of ethanol, caffeine, and clorazepate on hypertonic NaCl solution intake in rats.
Previous reports indicate that several anxiolytics enhance the intake of hypertonic saline in rehydrating rats. This experiment was conducted to determine the effects of repeated (5 sessions) injection (i.p.) of ethanol (0.4 or 0.8 g/kg), caffeine (20 or 40 mg/kg) or clorazepate (3 mg/kg) on the ingestion of hypertonic saline (1.8%) in water-deprived rats. Saline intake increased with the acute administration of both clorazepate and ethanol (two doses), but it decreased with caffeine (two doses). It seems that the increase or decrease of hypertonic saline ingestion following acute drug administration continues to correlate well with anxiolytic or anxiogenic actions. However, following repeated administration of caffeine and ethanol, the effects on saline intake were not maintained in a reliable manner.
Nadal
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Area de Psicobiologia, Facultat de Psicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Pallares
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MA
Ferre
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D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D003009:Clorazepate Dipotassium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D014868:Water Deprivation
D012462:Saline Solution, Hypertonic; D002110:Caffeine; D000431:Ethanol; D003009:Clorazepate Dipotassium