title: Effect of phenazone (antipyrine) on the prostanoid formation in human umbilical arteries perfused in vitro.
abstract: The influence of phenazone on the production of prostacyclin and thromboxane in human umbilical arteries was investigated by in vitro perfusion. With perfusate concentrations ranging from 10(-7) to 10(-4) M a decrease in the formation of both prostanoids was observed. The inhibitory effect of phenazone on prostanoid formation was found to be equal to that of indomethacin.
authors.affiliation: Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
authors.forename: G
authors.initials: G
authors.lastname: Haugen
authors.forename: S
authors.initials: S
authors.lastname: Stray-Pedersen
authors.forename: K
authors.initials: K
authors.lastname: Bjøro
mesh_terms: D000983:Antipyrine / Q000494:pharmacology* / Q000627:therapeutic use; D001095:Arachidonic Acids / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy; D011460:Prostaglandins F / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis; D014469:Umbilical Arteries / Q000187:drug effects* / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D011460:Prostaglandins F; D013929:Thromboxane B2; D000983:Antipyrine; C100006:prostaglandin F1; D007213:Indomethacin