title: Bran supplementation in the treatment of irritable bowel syndrome.
abstract: BACKGROUND
  Irritable bowel syndrome remains the commonest reason for referral to a gastroenterology clinic. Patients with irritable bowel syndrome are frequently advised to increase their intake of bran fibre, despite inconclusive experimental evidence of benefit.
  
  
  METHODS
  The effect of dietary supplementation with a bolus of bran fibre (12 g/day) was studied in a block-randomized, placebo-controlled, crossover study of 80 patients with irritable bowel syndrome referred to a District General Hospital outpatient clinic. Comparison of the benefits of bran and placebo was based upon personal assessment of individual and overall symptom profiles, determined from a simple daily symptom score and post-treatment interview.
  
  
  RESULTS
  Overall symptomatic improvement was reported with bran by 52% and with placebo by 54% of patients. Bran supplementation was no more effective than placebo in improving individual symptoms of irritable bowel syndrome, and for wind-related symptoms it was significantly less effective (P < 0.001).
  
  
  CONCLUSIONS
  Dietary supplementation with bran is of no value in the treatment of patients with irritable bowel syndrome referred to a hospital clinic.
authors.affiliation: Royal Hampshire County Hospital, Winchester, UK.
authors.forename: J
authors.initials: J
authors.lastname: Snook
authors.forename: H A
authors.initials: HA
authors.lastname: Shepherd
mesh_terms: D000328:Adult; D003109:Colonic Diseases, Functional / Q000178:diet therapy*; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014908:Triticum