Ultrafiltration and clearance studies in human isolated peritoneal vascular loops.
Eight samples of human peritoneal tissue were obtained from patients undergoing hemicholectomy for cancer. An artery and a vein were cannulated and perfused with blood in vitro with a special circuit able to provide different perfusion pressures. Ultrafiltration and clearance studies were performed in these samples. Both ultrafiltration and small-solute clearances linearly correlated with the blood flow, demonstrating a strong dependence on this parameter. The peritoneal capillary showed a typical filtration pressure equilibrium with a constant filtration fraction at different blood flows. The results suggest that the blood flow may be a factor limiting the efficiency of peritoneal dialysis both in terms of mass transfer coefficients and maximal ultrafiltration rates.
Ronco
C
C
Department of Nephrology, St. Bortolo Hospital, Vicenza, Italy.
Brendolan
A
A
Crepaldi
C
C
Conz
P
P
Bragantini
L
L
Milan
M
M
La Greca
G
G
D001769:Blood; D002199:Capillary Permeability; D003404:Creatinine / Q000493:pharmacokinetics; D006801:Humans; D007444:Inulin / Q000493:pharmacokinetics; D008970:Molecular Weight; D010477:Perfusion / Q000295:instrumentation; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000098:blood supply*; D012039:Regional Blood Flow; D014462:Ultrafiltration; D014508:Urea / Q000493:pharmacokinetics
D014508:Urea; D007444:Inulin; D003404:Creatinine