Two unusual neurological presentations of granulocytic sarcoma in Philadelphia positive chronic myeloid leukaemia.
Granulocytic sarcoma (GS) is a rare extramedullary tumour consisting of immature myeloid precursors. It occurs most commonly in association with myeloid leukaemias and myeloproliferative disorders. Rarely there may be no evidence of haematological malignancy. We describe neurological presentations of GS in two patients with Philadelphia (Ph) positive chronic myeloid leukaemia (CML). In both cases the bone marrow was in chronic phase at the time of presentation of the GS, but there was rapid subsequent transformation into the blastic phase.
Mahendra
P
P
Department of Haematology, Addenbrookes NHS Trust, Cambridge, UK.
Ager
S
S
Bedlow
A J
AJ
Bloxham
D M
DM
Green
A R
AR
Marcus
R E
RE
D000328:Adult; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009423:Nervous System Neoplasms / Q000473:pathology*