title: The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.
abstract: In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL--ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active. Taxol thus seems to contain two components active against patient tumour cells in vitro.
authors.affiliation: Department of Oncology, University Hospital, Uppsala University, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Nygren
authors.forename: K
authors.initials: K
authors.lastname: Csoka
authors.forename: B
authors.initials: B
authors.lastname: Jonsson
authors.forename: H
authors.initials: H
authors.lastname: Fridborg
authors.forename: J
authors.initials: J
authors.lastname: Bergh
authors.forename: H
authors.initials: H
authors.lastname: Hagberg
authors.forename: B
authors.initials: B
authors.lastname: Glimelius
authors.forename: O
authors.initials: O
authors.lastname: Brodin
authors.forename: B
authors.initials: B
authors.lastname: Tholander
authors.forename: A
authors.initials: A
authors.lastname: Kreuger
mesh_terms: D000970:Antineoplastic Agents / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D005470:Fluorometry; D005990:Glycerol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D009369:Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000633:toxicity*; D012997:Solvents / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D012997:Solvents; C000515:cremophor EL; D017239:Paclitaxel; D005990:Glycerol