Experience with amphotericin B in sodium stibogluconate--unresponsive cases of visceral Leishmaniasis in north Bihar.
One hundred cases of Indian Kala-azar unresponsive to sodium stibogluconate (SSG) were treated with amphotericin B. The drug was given in the dose schedule of 0.75 mg/kg body weight on alternate days intravenously dissolved in 5 percent dextrose solution. After 15 infusions given over a period of 30 days, all cases became clinically and parasitologically cured. Mild adverse reactions were noted during therapy. No relapse was observed at follow up after 12 months.
Giri
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OP
Department of Medicine, Darbhanga Medical College and Hospital, Laheriasaral, Darbhanga.
Singh
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AN
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007194:India; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D000666:Amphotericin B; D000967:Antimony Sodium Gluconate