title: Effect of nuclear localization signal-receptor interaction on nuclear envelope-associated ATPase activity.
abstract: The possibility that interaction of the nuclear localization signal (NLS) with its pore receptor may directly stimulate nuclear envelope-associated ATPase activity and consequently provide energy for protein translocation across the pore has been studied. ATPase activity was assayed after cross-linking of the prototype NLS peptide with its pore receptor, or after preincubation of envelopes with NLS-albumin conjugates. Neither treatment enhanced enzyme activity. A more complex series of events may be required for energy-generation at the nuclear pore.
authors.affiliation: Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: S
authors.initials: S
authors.lastname: Fatima
authors.forename: V K
authors.initials: VK
authors.lastname: Parnaik
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000502:physiology*; D008969:Molecular Sequence Data; D009685:Nuclear Envelope / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000251:Adenosine Triphosphatases