[Studies on antiulcer agents. I. The effects of various methanol and aqueous extracts of crude drugs on antiulcer activity].
The antiulcer activities of 59 methanol and aqueous extracts obtained from 59 crude drugs on the ethanol-HCl-induced ulceration in rats were investigated. Among them 15 extracts were selected and they were further examined for their effects on indomethacin-, aspirin- and the water-immersion stress-induced ulcer. From these results, the methanol extract of root of Iris germanica was found to, show potent antiulcer activities. The above methanol extract was separated into 3 portions by solvent extraction, and the ether soluble portion was fractionated into 5 fractions (1 to 5) by chromatography. Fractions 4 and 5 showed significant antiulcer activities. Fraction 4 was further purified and the obtained gamma-irigermanal exhibited a potent antiulcer activity. However, further investigations are required to understand the mechanism.
Muto
Y
Y
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
Ichikawa
H
H
Kitagawa
O
O
Kumagai
K
K
Watanabe
M
M
Ogawa
E
E
Seiki
M
M
Shirataki
Y
Y
Yokoe
I
I
Komatsu
M
M
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D000432:Methanol; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000188:drug therapy*; D014867:Water
D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D014867:Water; D000432:Methanol