A novel halogenated compound possessing antibiotic and cytotoxic activities isolated from the fungus Resinicium pinicola (J. Erikss.) Erikss. & Hjortst.
Pinicoloform, a novel unbranched acyclic compound containing a trichloromethyl group, has been isolated from extracts of the mycelia of the Basidiomycete Resinicium pinicola. It was isolated because of its ability to induce morphological and physiological differentiation of mammalian cells, although it also exhibits antibiotic and cytotoxic activities. The structure of pinicoloform was determined by spectroscopic methods.
Becker
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Lehrbereich Biotechnologie der Universität Kaiserslautern, Bundesrepublik Deutschland.
Anke
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Sterner
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D001487:Basidiomycota / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002725:Chloroform / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006224:Cricetinae; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D007668:Kidney; D015473:Leukemia, Promyelocytic, Acute; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D005233:Fatty Alcohols; C092215:pinicoloform; D002725:Chloroform