Unrestricted T cell-mediated cytotoxicity to major histocompatibility antigen generated with tumor hybrid cells.
Splenic T cells from C3H/He mice injected with the LFM3A#2 hybrid cells intraperitoneally (i.p.) showed cytotoxic activity against the parental FM3A/R tumor cells. We studied the target antigens recognized by cytotoxic T cells (CTL) and the following results were obtained. 1) CTL specifically recognized the MM antigens on the surface of target cells in effector phase. 2) The H-2K or H-2D antigens were not involved in T cell effector function.
Kambe
M
M
Department of Clinical Oncology, Tohoku University, Sendai.
Tachibana
T
T
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005260:Female; D006183:H-2 Antigens / Q000276:immunology; D006822:Hybrid Cells / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013154:Spleen / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D014407:Tumor Cells, Cultured
D000951:Antigens, Neoplasm; D006183:H-2 Antigens; D007518:Isoantibodies; D007519:Isoantigens