Long-term depression requiring tACPD-receptor activation and NMDA-receptor blockade.
In slices from the rat visual cortex, application of the metabotropic glutamate receptor (mGluR) agonist trans-1-aminocyclo-pentane-1,3-dicarboxylic acid (tACPD), whether combined with tetanization or not, produced only a reversible depression but not long-term depression (LTD) of synaptic transmission. In the presence of both tACPD and the NMDA receptor antagonist D-(-)-2-amino-5-phosphonopentanoate, tetanization induced LTD. These findings suggest requirement of tACPD-sensitive mGluR subtypes for inducing a form of LTD in the visual cortex.
Kato
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Department of Integrative Brain Science, Faculty of Medicine, Kyoto University, Japan.
D000818:Animals; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D009498:Neurotoxins / Q000494:pharmacology; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D009435:Synaptic Transmission / Q000187:drug effects*; D013746:Tetany / Q000139:chemically induced; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology; D014793:Visual Cortex / Q000187:drug effects*
D009498:Neurotoxins; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C073111:metabotropic quisqualate receptor; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; C056639:2-amino-5-phosphopentanoic acid; D014633:Valine