[Recommended methods for the determination of catecholamines and their metabolites in urine. Significance of results in the diagnosis and follow-up of pheochromocytoma and neuroblastoma].
Laboratory investigation of catecholamines is useful for the clinician in the diagnosis and management of phaeochromocytoma and neuroblastoma. This work summarizes current knowledge on catecholamines and their metabolites and discusses the main indications for their determination. It also examines the most practical methods for studying the secretion of these hormones, ie extraction, separation and quantification using high performance liquid chromatography coupled with electrochemical detection. The workshops attended by the members of the catecholamines working party of the French Clinical Biology Society and phaeochromocytoma and neuroblastoma specialists enabled the role of such determinations in the diagnosis and management of these diseases to be clarified.
Revol
A
A
Laboratoire d'hormonologie, centre hospitalier Lyon-Sud, Pierre-Bénite, France.
Comoy
E
E
Forzy
G
G
Garnier
J P
JP
Gerhardt
M F
MF
Hirth
C
C
Jacob
N
N
Mathieu
P
P
Patricot
M C
MC
Peyrin
L
L
D000293:Adolescent; D000328:Adult; D002395:Catecholamines / Q000378:metabolism* / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004563:Electrochemistry; D005500:Follow-Up Studies; D006801:Humans; D062385:Hydroxybenzoates / Q000652:urine; D007223:Infant; D008729:Methoxamine / Q000652:urine; D009447:Neuroblastoma / Q000175:diagnosis / Q000652:urine*; D010673:Pheochromocytoma / Q000175:diagnosis / Q000652:urine*
D002395:Catecholamines; D062385:Hydroxybenzoates; D008729:Methoxamine; C017616:phenolic acid
Méthodes recommandées pour le dosage des catécholamines et de leurs métabolites dans l'urine. Signification des résultats dans le diagnostic et le suivi des phéochromocytomes et des neuroblastomes.