title: The effect of radix salviae miltiorrhizae composita and ligustrazine on lipid peroxidation in low density lipoprotein due to copper dichloride.
abstract: It is well known that lipid peroxide in low density lipoprotein (LDL) plays an important role in atherosclerosis and atherosclerotic diseases. We used oxidized LDL generated by incubating LDL from healthy persons with copper dichloride as a model to investigate the anti-lipid-peroxide property of Radix Salviae Miltiorrhizae Composita (RSMC) and ligustrazine. The changes in concentrations of lipid peroxide and lipids in LDL due to Cu++ were studied, and the effects of RSMC and ligustrazine on the changes were studied. The results in our study indicate that RSMC has a potential role on anti-lipid-peroxidation, but it was not found that ligustrazine has similar anti-peroxidation action.
authors.affiliation: Department of Neurology, 261 Hospital, Beijing.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: P
authors.initials: P
authors.lastname: Kuang
authors.forename: K
authors.initials: K
authors.lastname: Takemichi
authors.forename: O
authors.initials: O
authors.lastname: Kogo
authors.forename: M
authors.initials: M
authors.lastname: Hirobumi
authors.forename: O
authors.initials: O
authors.lastname: Yasaburo
mesh_terms: D000328:Adult; D003300:Copper / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011719:Pyrazines / Q000494:pharmacology*; D027561:Salvia miltiorrhiza
chemical_list: D004365:Drugs, Chinese Herbal; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; D003300:Copper; C028419:cuprous chloride; C017953:tetramethylpyrazine