A review of studies of the activation of the blood coagulation mechanism in chimpanzees (Pan troglodytes).
This paper reviews our recent studies of blood coagulation activation in the chimpanzee which were carried out employing sensitive immunoassays that measure activation markers of blood coagulation in plasma. Infused factor VIIa activated both factors IX and X in vivo; this reaction depended on the formation of the factor VIIa-tissue factor (TF) complex. The infusion of endotoxin also led to assembly of the factor VIIa-TF complex, enhancing fibrin formation. This process occurred through the intermediate action of specific cytokines.
ten Cate
H
H
Center for Thrombosis, Hemostasis, Atherosclerosis, and Inflammation Research, Academic Medical Center, Amsterdam, The Netherlands.
Schenk
B E
BE
Biemond
B J
BJ
Levi
M
M
van der Poll
T
T
Buller
H R
HR
ten Cate
J W
JW
D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D015942:Factor VIIa / Q000502:physiology; D005246:Feedback; D008954:Models, Biological; D002679:Pan troglodytes / Q000097:blood*; D013925:Thromboplastin / Q000502:physiology
D001779:Blood Coagulation Factors; D016207:Cytokines; D013925:Thromboplastin; D015942:Factor VIIa