Viscum album L. extracts reduce sister chromatid exchanges in cultured peripheral blood mononuclear cells.
Increasing concentrations of Viscum album L. extracts were shown to significantly reduce sister chromatid exchange (SCE) frequency of phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) of healthy individuals. This decrease of SCE could not be explained either by changes in lymphocyte subpopulations, by cytostatic effects of the drug or by accelerated proliferation of PHA-stimulated PBMC. Currently, no other cells tested have shown this effect. One therapeutic effect of these anti-mutagenic drugs could be a stabilisation of mononuclear blood cell DNA.
Büssing
A
A
Institute of Medical Immunology, Medical Faculty, Technical University Aachen, F.R.G.
Azhari
T
T
Ostendorp
H
H
Lehnert
A
A
Schweizer
K
K
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D016131:Lymphocyte Subsets / Q000187:drug effects; D008297:Male; D014784:Mistletoe / Q000737:chemistry*; D008938:Mitosis / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D037121:Plant Lectins; D010946:Plants, Medicinal; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D010835:Phytohemagglutinins; D010936:Plant Extracts; D037121:Plant Lectins