title: Photoactive terthiophenes: the influence of serum on anti-HIV (human immunodeficiency virus) activities.
abstract: A number of carboxylic acid derivatives of the photoactive terthiophene, alpha-terthienyl, were found to possess impressive UVA-dependent activity against the human immunodeficiency virus, HIV-1; but only when assayed in the absence of serum, indicating that the latter contained interfering components. Good antiviral activity required a high rate of singlet oxygen production, in accordance with previous observations on thiophenes.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: J B
authors.initials: JB
authors.lastname: Hudson
authors.forename: R J
authors.initials: RJ
authors.lastname: Marles
authors.forename: C
authors.initials: C
authors.lastname: Soucy-Breau
authors.forename: L
authors.initials: L
authors.lastname: Harris
authors.forename: J T
authors.initials: JT
authors.lastname: Arnason
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001769:Blood; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010100:Oxygen; D017319:Photosensitizing Agents / Q000494:pharmacology*; D026082:Singlet Oxygen; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D017319:Photosensitizing Agents; D013876:Thiophenes; C019101:alpha-terthienyl; D026082:Singlet Oxygen; D010100:Oxygen