[Prevention of new cases of the disease in families of hemophilia patients in Moscow using a genetic register].
The genetic familial register in question contains information on 441 hemophilia patients. Two-thirds of the patients suffered from moderate or severe hemophilia, 81.3% had hemophilia A. Fifty-two families with the latter disease were examined with molecular methods which confirmed heterozygous carriage in 40% of the female examinees. The prenatal diagnosis in two families led to delivery of healthy boys. The genetic register provides effective protection for hemophiliac families.
Pliushch
O P
OP
Izhevskaia
V L
VL
Likhacheva
E A
EA
D005260:Female; D006580:Genetic Carrier Screening; D006467:Hemophilia A / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009031:Moscow / Q000453:epidemiology; D012042:Registries; D012307:Risk Factors
Profilaktika povtornykh sluchaev zabolevaniia v sem'iakh bol'nykh gemofilieĭ v Moskve s ispol'zavaniem geneticheskogo registra.