The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides.
The alpha/immediate early genes of herpes simplex virus are regulated by the specific assembly of a multiprotein enhancer complex containing the Oct-1 POU domain protein, the viral alpha-transinduction factor alpha TIF, (VP16, ICP25), and the C1 cellular factor. The C1 factor from mammalian cells is a heterogeneous but related set of polypeptides that interact directly with the alpha-transinduction factor to form a heteromeric protein complex. The isolation of cDNAs encoding the polypeptides of the C1 factor suggests that these proteins are proteolytic products of a novel precursor. The sequence of the amino termini of these polypeptide products indicate that the proteins are generated by site-specific cleavages within a reiterated 20-amino acid sequence. Although the C1 factor appears to be ubiquitously expressed, it is localized to subnuclear structures in specific cell types.
Kristie
T M
TM
Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Pomerantz
J L
JL
Twomey
T C
TC
Parent
S A
SA
Sharp
P A
PA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D018076:DNA, Complementary; D004742:Enhancer Elements, Genetic; D006367:HeLa Cells; D017405:Herpes Simplex Virus Protein Vmw65 / Q000235:genetics* / Q000378:metabolism; D051863:Host Cell Factor C1; D006801:Humans; D007106:Immune Sera; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010455:Peptides; D011506:Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D018139:Simplexvirus / Q000235:genetics*; D018411:Spodoptera; D014157:Transcription Factors
D018076:DNA, Complementary; C497692:HCFC1 protein, human; D017405:Herpes Simplex Virus Protein Vmw65; D051863:Host Cell Factor C1; D007106:Immune Sera; D010455:Peptides; D011506:Proteins; D014157:Transcription Factors