[Results of the 75selenium homotaurocholic acid retention test (SeHCAT test) in diagnosis of diarrhea].
METHODS
For that reason absorption of bile acids was investigated using the 75Se-homotaurocholate (SeHCAT) in 239 patients with diarrhoea. SeHCAT retention time was measured as 7 day retention time in a whole body counter. An intact bile acid absorption (negative SeHCAT test) was confirmed in 23 healthy volunteers within the range of 11 to 50% (mean +/- double standard deviation).


RESULTS
In 135 patients with a possible type I bile salt malabsorption the SeHCAT test was positive in 78%, thus indicating bile salt malabsorption. The test is very sensitive detecting bile salt malabsorption in Crohn's disease, identifying ileal disease more precisely than radiology. The SeHCAT test ascertained type II primary bile salt malabsorption in 7 patients, as well as type III bile salt malabsorption in patients (9 out of 28) with cholecystectomy, vagotomy, partial gastrectomy and chronic pancreatitis. In addition, a positive SeHCAT test indicating bile acid malabsorption was found in 5 out of 11 patients with irritable syndrome, diarrhoeic form, and in 4 out of 12 patients with lactose intolerance.


CONCLUSIONS
SeHCAT retention should be measured routinely in patients with chronic diarrhoea for which the cause is not obvious.
Balzer
K
K
Medizinische Klinik I, Kreiskrankenhaus Herford.
Schmitt
G
G
Reiners
C
C
Goebell
H
H
D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism*; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D008286:Malabsorption Syndromes / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012016:Reference Values; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid / Q000031:analogs & derivatives*
D001647:Bile Acids and Salts; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid
Befunde mit dem 75Selen-Homotaurocholsäure-Retentionstest (SeHCAT-Test) in der Diagnostik von Diarrhöen.