A yellow component associated with human transthyretin has properties like a pterin derivative, 7,8-dihydropterin-6-carboxaldehyde.
Transthyretin (TTR) in plasma is associated with yellow compounds. Their properties differ, and in the chicken protein a major yellow compound has recently been identified as a carotenoid, lutein, also called xanthophyll. We now show that the major yellow component extracted from human TTR has properties like a pterin derivative, 7,8-dihydropterin-6-carboxyaldehyde (2-amino-4-hydroxy-6-formyl-7,8-dihydropteridine). The human TTR derivative has chromatographic and spectral properties identical to a yellow photochemical degradation product of biopterin and a spectrum like that of the pterin aldehyde.
Ernström
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Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Pettersson
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Jörnvall
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D002831:Choroid Plexus / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D011228:Prealbumin / Q000737:chemistry*; D011621:Pteridines / Q000097:blood* / Q000737:chemistry; D011622:Pterins / Q000097:blood*; D013057:Spectrum Analysis; D013974:Thyroxine / Q000097:blood
C092391:7,8-dihydropterin-6-carboxaldehyde; D011228:Prealbumin; D011621:Pteridines; D011622:Pterins; D013974:Thyroxine