title: [Histopathology of chronic myeloid leukemia in diagnostic biopsies of bone marrow].
abstract: Histopathology of the bone marrow of diagnostic biopsies prior to any therapy is described in a total of 412 Ph1-positive patients. Special attention is paid to the distribution of megakaryocytes, increase of fibres and blasts, and occurrence of storing histiocytes of pseudo-Gaucher type. Megakaryocytes were significantly increased in 31.6% of diagnostic biopsies, myelofibrosis was found in 15.8%, significant increase of blasts in 2.4%. Pseudo-Gaucher cells were detected in 57.8% of a total of 412 biopsies. These histiological features are considered as an indication of the progress of the disease. A semiquantitative specification of CML by this criteria is described which can be performed rather reliably and defines the stage of CML at diagnosis prior to substantial treatment.
authors.affiliation: Pathologisches Institut, Medizinische Hochschule Hannover.
authors.forename: G
authors.initials: G
authors.lastname: Büsche
authors.forename: T
authors.initials: T
authors.lastname: Buhr
authors.forename: A
authors.initials: A
authors.lastname: Georgii
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000145:classification / Q000473:pathology*; D008533:Megakaryocytes / Q000473:pathology; D055728:Primary Myelofibrosis / Q000145:classification / Q000473:pathology; D011379:Prognosis
vernacular_title: Histopathologie der chronischen myeloischen Leukämie in diagnostischen Biopsien vom Knochenmark.