title: Comparison of salt sensitivity of male and female F2 progeny from crosses between WKY and SHRSP rats.
abstract: 1. The present study compared the salt sensitivity of male and female F2 progeny obtained from crosses between Wistar-Kyoto/Izumo rats and stroke-prone spontaneously hypertensive rats (SHRSP A3b/Izm) after salt loading for 7 months. 2. Average systolic blood pressure in male F2 progeny was 10 mmHg higher than that of female F2 progeny at 5 months without salt loading. 3. The blood pressure in male F2 progeny was raised significantly 2 months after salt loading, but there was no further significant change in blood pressure even though salt loading was continued for 5 months. 4. In female F2 progeny, however, a significant change in systolic blood pressure was observed 1 month after salt loading and there was a further significant rise in blood pressure over 6 months. 5. Angiotensin I-converting enzyme and RR1023 loci were strongly linked to systolic and diastolic blood pressures in the male but not the female F2 progeny after salt loading for 7 months. 6. We therefore speculate that the hormonal difference between sexes might influence salt sensitivity in the SHRSP.
authors.affiliation: Graduate School of Human and Environmental Studies, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nara
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Nabika
authors.forename: M
authors.initials: M
authors.lastname: Sawamura
authors.forename: M
authors.initials: M
authors.lastname: Mano
authors.forename: J
authors.initials: J
authors.lastname: Endo
authors.forename: Y
authors.initials: Y
authors.lastname: Yamori
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics*; D011921:Rats, Inbred WKY / Q000235:genetics*; D012737:Sex Factors; D017673:Sodium Chloride, Dietary / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D017673:Sodium Chloride, Dietary