Single mandibular incisor in a patient with del (18p) anomaly.
A single mandibular incisor and an unusually narrow mandible and tongue were noted in an 8-year-old moderately retarded boy with 18p- (45, XY, der dic (18) (18qter-p11.2::22p 11.2-qter). While a single maxillary incisor, considered a minor feature of holoprosencephaly, was reported in three cases of 18p-, reduction of mandibular incisors has been a very rare finding and has never been noted in similar cases.
Pfeiffer
R A
RA
Institut für Humangenetik, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany.
Hertrich
K
K
Cohen
M
M
D000848:Anodontia / Q000235:genetics*; D002648:Child; D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D006801:Humans; D007180:Incisor / Q000002:abnormalities*; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D008334:Mandible / Q000002:abnormalities*; D063173:Retrognathia / Q000235:genetics; D014059:Tongue / Q000002:abnormalities