Genotoxicity of polychlorinated biphenyls (PCBs): recombinogenesis by biotransformation products.
A coplanar polychlorinated biphenyl (PCB) when eaten by test animals increased the rate of recombination in somatic cells, indicating a new mechanism of action for these compounds. Using the eye-mosaic test a high bioactivation strain of Drosophila that consumed 4,4'-dichlorobiphenyl (4,4'-DCB) manifested a genotoxicity rate that was three-fold greater than that in animals fed the solvent-spiked medium. This compound was not genotoxic in a suppressed bioactivation strain indicating that genotoxicity requires bioactivation of the compound. High bioactivation test strains made heterozygous for a paracentric inversion, a chromosomal rearrangement that suppresses homologous recombination, exhibited significantly reduced genotoxicity after treatment.
Butterworth
F M
FM
Department of Biological Sciences, Oakland University, Rochester, MI 48309.
Pandey
P
P
McGowen
R M
RM
Ali-Sadat
S
S
Walia
S
S
D000818:Animals; D001711:Biotransformation; D004330:Drosophila / Q000235:genetics; D005260:Female; D006579:Heterozygote; D008297:Male; D009030:Mosaicism; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity*; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics / Q000633:toxicity*; D011995:Recombination, Genetic
D009153:Mutagens; D011078:Polychlorinated Biphenyls