Role of GABAA and GABAB receptors and peripheral cholinergic mechanisms in the antinociceptive action of taurine.
1. Gabaergic and cholinergic mediation in the antinociceptive effect of taurine has been investigated in mice (acetic acid test) and rats (tail-flick test). 2. Scopolamine sulfate and methylnitrate exhibit intrinsic antinociceptive activity and increase the effect of taurine in mice. 3. Baclofen also increases the antinociceptive effect of taurine in mice. 4. Anticholinergic agents and bicuculline but not CGP 35348 antagonize the effect of taurine in rats. 5. These results suggest that the antinociceptive effect of taurine may be partly mediated by spinal GABAA receptors and peripheral cholinergic mechanisms.
Serrano
M I
MI
Department of Pharmacology, University Hospital Macarena, Sevilla, Spain.
Serrano
J S
JS
Guerrero
M R
MR
Fernández
A
A
D000700:Analgesics / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017208:Rats, Wistar; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D018080:Receptors, GABA-B / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology; D013654:Taurine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000700:Analgesics; D018680:Cholinergic Antagonists; D011950:Receptors, Cholinergic; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D013654:Taurine; D012601:Scopolamine; D001418:Baclofen