title: Isolated toxoplasmosis of the thoracic spinal cord in a patient with acquired immunodeficiency syndrome. Case report.
abstract: Toxoplasmosis and lymphoma are the two most common causes of intraparenchymal cerebral mass lesions in patients with acquired immunodeficiency syndrome (AIDS). The clinical and radiographic features of the intracranial lesions have been well described. Because of the high frequency of toxoplasmosis in the AIDS population, common therapy for patients presenting with intracranial mass lesions consists of an empirical trial of anti-Toxoplasma chemotherapy, with biopsy reserved for cases demonstrating features considered to be more consistent with lymphoma, or for lesions that do not improve despite adequate anti-Toxoplasma treatment. A similar treatment algorithm does not exist for intramedullary lesions of the spinal cord. The authors describe a patient who presented with paraparesis resulting from an isolated thoracic intramedullary lesion. An open biopsy of the lesion revealed characteristic structures containing Toxoplasma tachyzoites. The clinical and radiographic presentation of the lesion is discussed, the available literature is reviewed, and a treatment strategy for spinal cord lesions in AIDS patients is proposed.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: D K
authors.initials: DK
authors.lastname: Resnick
authors.forename: C H
authors.initials: CH
authors.lastname: Comey
authors.forename: W C
authors.initials: WC
authors.lastname: Welch
authors.forename: A J
authors.initials: AJ
authors.lastname: Martinez
authors.forename: W W
authors.initials: WW
authors.lastname: Hoover
authors.forename: G B
authors.initials: GB
authors.lastname: Jacobs
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001706:Biopsy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D014123:Toxoplasmosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology