Synthesis and pharmacological properties of some new 3-(2-N,N-dialkylaminoethyl)-pyrido [2,3-d]-pyrymidin-4-ones.
The following new derivatives of pyrido [2,3-d]-pyrimidin-4(3H)-one were synthesized: 3-(2-N,N-dimethylaminoethyl), 3-(2-N-pyrolidynylethyl), 3-(2-piperidinylethyl) and 3-(2-N-morpholidinylethyl). Their chemical structures were confirmed by MS, IR and 1H NMR spectroscopic data. Newly synthesized compounds were investigated pharmacologically for their central properties in mice and rats. It was shown that compound [III] showed anxiolytic action in the four-plate test and two compounds produced analgesic effects in mice.
Kowalska
T
T
Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków.
Kowalski
P
P
Rutkowski
K
K
Woźniak
M
M
Kleinrok
Z
Z
Jagiełło-Wójtowicz
E
E
Szurska
G
G
Chodkowska
A
A
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D014151:Anti-Anxiety Agents; D011743:Pyrimidines