title: [Malignant astrocytoma of the cerebellum. Apropos of 10 cases. Review of the literature].
abstract: While reviewing a series of 138 cerebellar tumors operated upon between 1978 and 1991, the authors could only find 2 glioblastomas and 8 anaplastic astrocytomas, occurring in 4 children (3 to 14 years old) and 6 adults (23 to 48 years old). These 10 cases represent 2% of the all malignant gliomas population observed during the same period of time. Clinically speaking, nothing makes these tumors different from other cerebellar ones. However, with an heterogenous image and an irregular contrast enhancement, the CT (scan) appearance can lead to the diagnosis. 7 lesions develop within the cerebellar vermis (vermis cerebelli) and 3 develop within the cerebellar hemisphere. Total surgical resection is performed in 9 cases and subtotal resection in 1 case (because of the extension to the floor of the fourth ventricle). Adjunctive radiotherapy on their posterior cranial fossa is achieved in 8 cases. The 2 patients with a glioblastoma present with a recurrence of their tumor at 15 months and 6 years respectively, and eventually died. Out of the patients with an anaplastic astrocytoma, 4 are still alive without recurrence and with a median follow-up of 7 years. The pathogenesis of such lesions is discussed. An aggressive therapeutic management is suggested because of the possible prolonged survival rate.
authors.affiliation: Service de Neurochirurgie, Centre Hospitalier et Universitaire, Angers.
authors.forename: T
authors.initials: T
authors.lastname: Rizk
authors.forename: J
authors.initials: J
authors.lastname: Remond
authors.forename: G
authors.initials: G
authors.lastname: Alhayek
authors.forename: D
authors.initials: D
authors.lastname: Fournier
authors.forename: P
authors.initials: P
authors.lastname: Menei
authors.forename: P
authors.initials: P
authors.lastname: Mercier
authors.forename: G
authors.initials: G
authors.lastname: Guy
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis / Q000628:therapy*; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
vernacular_title: Astrocytomes malins du cervelet. A propos de dix cas. Revue de la littérature.