Changes of blood viscosity in patients treated with 5-fluorouracil--a link to cardiotoxicity?
Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU. The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients.
Cwikiel
M
M
Department of Oncology, University Hospital Lund, Sweden.
Persson
S U
SU
Larsson
H
H
Albertsson
M
M
Eskilsson
J
J
D000328:Adult; D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D005340:Fibrinogen / Q000187:drug effects; D005472:Fluorouracil / Q000009:adverse effects*; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006331:Heart Diseases / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D006400:Hematocrit; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged
D005340:Fibrinogen; D005472:Fluorouracil