Functional and antiischemic effects of luteolin-7-glucoside in isolated rabbit hearts.
1. The functional effects of the flavonoid luteolin-7-glucoside (LUT) were investigated in Langendorff-rabbit hearts perfused at constant pressure. Repetitive myocardial ischemia was induced by coronary artery ligature and quantified from NADH-fluorescence photography. 2. LUT significantly enhanced left ventricular pressure and the global and relative coronary flow (= global coronary flow/pressure-rate product). 3. LUT significantly diminished epicardial NADH-fluorescence area and intensity. 4. LUT is an inodilator possessing cardioprotective properties. These might be related to an improvement of myocardial perfusion and/or to free radical scavenging properties.
Rump
A F
AF
Institut für Pharmakologie, Universität Köln, Germany.
Schüssler
M
M
Acar
D
D
Cordes
A
A
Theisohn
M
M
Rösen
R
R
Klaus
W
W
Fricke
U
U
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D005453:Fluorescence; D016166:Free Radical Scavengers; D005960:Glucosides / Q000494:pharmacology*; D066298:In Vitro Techniques; D047311:Luteolin; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology*; D009243:NAD / Q000378:metabolism; D010477:Perfusion; D010726:Phosphodiesterase Inhibitors; D011817:Rabbits; D016277:Ventricular Function, Left / Q000187:drug effects*
D005419:Flavonoids; D016166:Free Radical Scavengers; D005960:Glucosides; D010726:Phosphodiesterase Inhibitors; D009243:NAD; C066408:luteolin-7-glucoside; D047311:Luteolin