title: Mammalian G1 cyclins.
abstract: D- and E-type cyclins regulate the progression of mammalian cells through the G1 phase of the cell cycle. The mechanisms responsible for the accumulation and activation of kinases dependent on cyclins D and E in both normal and cancerous cells have recently been uncovered. Overexpression of cyclin D1 protein as a consequence of genetic rearrangements, and deletions or mutations of the p16INK4 gene have been demonstrated in a large variety of human cancers, including breast and esophageal carcinomas, lymphomas, bladder carcinoma, pancreatic adenocarcinoma and familial melanoma.
authors.affiliation: Mitotix Incorporated, Cambridge.
authors.forename: G F
authors.initials: GF
authors.lastname: Draetta
mesh_terms: D000818:Animals; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism*; D004789:Enzyme Activation; D016193:G1 Phase / Q000502:physiology*; D006801:Humans; D008322:Mammals; D009369:Neoplasms / Q000378:metabolism
chemical_list: D016213:Cyclins; D018844:Cyclin-Dependent Kinases