Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates.
The present study investigates the inhibition of lipid peroxidation by dehydrozingerone and curcumin in rat brain homogenates. Both the test compounds inhibited the formation of conjugated dienes and spontaneous lipid peroxidation. These compounds also inhibited lipid peroxidation induced by ferrous ions, ferric-ascorbate and ferric-ADP-ascorbate. In all these cases, curcumin was more active than dehydrozingerone and dl-alpha-tocopherol.
Rajakumar
D V
DV
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Rao
M N
MN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D003474:Curcumin / Q000494:pharmacology*; D005260:Female; D058085:Iron Compounds / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D013343:Styrenes / Q000494:pharmacology*; D014020:Tissue Extracts / Q000378:metabolism
D000975:Antioxidants; D058085:Iron Compounds; D013343:Styrenes; D014020:Tissue Extracts; C052933:methyl-3-methoxy-4-hydroxystyryl ketone; D003474:Curcumin