title: A radiographic study of the effect of various retrograde fillings on periapical healing after replantation.
abstract: An effective retrograde sealing procedure places great demands upon both technique and materials. Prevention of micro-leakage, biocompatibility and stability of the material in the apical tissues are very important. To evaluate potential retrograde filling materials, a replantation model has been developed in which extracted permanent molars were replanted in monkeys after apicectomy of each root, preparation of a 2-mm deep retrograde cavity and its sealing with various dental materials. Prior to retro-filling the remaining pulp was exposed to saliva. Apicected molars which were infected and did not receive retrograde fillings served as positive controls. Periapical healing was evaluated radiographically after 8 weeks based on planimetric measurements of the size of the periapical radiolucency. The following dental materials were tested: amalgam, glass ionomer cement, calcium-hydroxide lining cement, AH 26 root canal sealer, various zinc oxide-eugenol cements, Cavit, and gutta-percha with various sealers. The materials which were associated with better apical healing than the infected controls were glass ionomer cement, Cavit, and the zinc oxide-eugenol cements. When plain zinc oxide-eugenol or IRM were combined with a gutta-percha core, healing was best and not statistically different from normal apices. It was concluded that radiographic assessment at 8 weeks of molar teeth retrograde filled prior to replantation could be a valuable method for discrimination of potentially useful materials in vivo.
authors.affiliation: Department of Oral Surgery, National Hospital (Rigshospitalet), Copenhagen, Denmark.
authors.forename: J O
authors.initials: JO
authors.lastname: Andreasen
authors.forename: T R
authors.initials: TR
authors.lastname: Pitt Ford
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001047:Apicoectomy; D001729:Bismuth; D002133:Calcium Sulfate; D002522:Chlorocebus aethiops; D003738:Dental Cements; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004853:Epoxy Resins; D006171:Gutta-Percha; D008709:Methenamine; D008768:Methylmethacrylates; D010486:Periapical Tissue / Q000000981:diagnostic imaging / Q000187:drug effects*; D011145:Polyvinyls; D011859:Radiography; D012184:Retrograde Obturation; D012387:Root Canal Filling Materials; D012834:Silver; D018709:Statistics, Nonparametric; D014025:Titanium; D014090:Tooth Replantation; D014945:Wound Healing / Q000187:drug effects*; D015034:Zinc Oxide; D015035:Zinc Oxide-Eugenol Cement
chemical_list: D003738:Dental Cements; D004338:Drug Combinations; D004853:Epoxy Resins; D008768:Methylmethacrylates; D011145:Polyvinyls; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; D012834:Silver; C028044:epoxy resin AH-26; C031667:IRM cement; C020872:Cavit; D006171:Gutta-Percha; D014025:Titanium; D008709:Methenamine; D015034:Zinc Oxide; D001729:Bismuth; D002133:Calcium Sulfate