title: Changes in S-type lectin localization in neuroblastoma cells (N1E115) upon differentiation.
abstract: The distribution of a 14.4 kDa S-type lectin was examined in murine neuroblastoma cells, either undifferentiated or after differentiation induced by dibutyryl-cyclic adenosine monophosphate. In undifferentiated cells the immunoreactivity was detected extracellularly, associated with the plasma membrane and in bulges released into the extracellular milieu. Important modifications of the lectin localization were associated with the differentiation process that induced an increased cytosolic expression and a decreased externalization. Possible functions for the lectin expressed intracellularly in the differentiated cells are also considered.
authors.affiliation: Laboratoire de Biochimie et Technologie des Protéines, Université Paris-Nord, UFR SMBH Léonard de Vinci, Bobigny, France.
authors.forename: V
authors.initials: V
authors.lastname: Avellana-Adalid
authors.forename: G
authors.initials: G
authors.lastname: Rebel
authors.forename: M
authors.initials: M
authors.lastname: Caron
authors.forename: J D
authors.initials: JD
authors.lastname: Cornillot
authors.forename: D
authors.initials: D
authors.lastname: Bladier
authors.forename: R
authors.initials: R
authors.lastname: Joubert-Caron
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D001923:Brain Chemistry / Q000502:physiology*; D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002999:Clone Cells; D007124:Immunoenzyme Techniques; D037102:Lectins / Q000032:analysis*; D051379:Mice; D009447:Neuroblastoma; D009474:Neurons / Q000737:chemistry* / Q000166:cytology; D014407:Tumor Cells, Cultured
chemical_list: D037102:Lectins; D003994:Bucladesine