title: [Redox therapy in mitochondrial diseases using coenzyme Q10].
abstract: BACKGROUND
  The biochemical and genetic analysis served as the basis for the definition of the following mitochondrial diseases (mt diseases) and the diseases of the mitochondrial deoxyribonucleic acid (mtDNA diseases): mitochondrial myopathy, encephalomyopathy, and cardiomyopathy. The therapy of mitochondrial diseases (in both practice and experiment) belongs to the current trends of research.
  
  
  OBJECTIVE
  The study does not present any new experimental results but in their literary review the authors indicate: a) new trend in biochemical studies of mitochondrial diseases, b) some current knowledge on mtDNA diseases, c) the current trend of mitochondrial disease "redox therapy" by CoQ10, d) significance of the therapeutic task of CoQ10 in four experimental models of the myocardial mitochondria impairment (by ageing, smoking, alcohol, ischemia).
  The authors indicate a new perspective for the studies of mitochondrial diseases (mt diseases) and the diseases of the mitochondrial deoxyribonucleic acid (mtDNA diseases) and their therapy not only under experimental conditions, but also in the blood and bioptic samples of patients. (Tab. 3, Fig. 2, Ref. 43.)
authors.affiliation: Farmakobiochemické laboratórium LFUK, Bratislave.
authors.forename: A
authors.initials: A
authors.lastname: Gvozdjáková
authors.forename: J
authors.initials: J
authors.lastname: Kucharská
authors.forename: J
authors.initials: J
authors.lastname: Gvozdják
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D017240:Mitochondrial Myopathies / Q000188:drug therapy* / Q000378:metabolism; D014451:Ubiquinone / Q000627:therapeutic use*
chemical_list: D014451:Ubiquinone
vernacular_title: "Redox terapia" mitochondriálnych chorôb koenzýmom Q10.