title: [Excretion of beta-2-microglobulin in hypertension].
abstract: The study aimed at evaluating an excretion of beta 2-microglobulin with the urine of hypertensive patients. Thirty patients with mild-to-moderate hypertension (diastolic blood pressure 14.26 +/- 0.86 kPa) and 13 patients with severe hypertension (diastolic blood pressure 17.8 +/- 1.7 kPa) were included into the studies. Significantly increased beta 2-microglobulin excretion with the urine was noted in both groups with the highest values in patients with severe blood hypertension. Moreover, significant correlation between tubular reabsorption of beta 2-microglobulin and diastolic blood pressure was noted in both groups. Increased excretion of beta 2-microglobulin in the arterial hypertension may be due to an increased glomerular filtration of this protein and/or decreased reabsorption in proximal tubule.
authors.affiliation: Kliniki Nadciśnienia Tetniczego Instytutu Kardiologii AM, Poznaniu.
authors.forename: D
authors.initials: D
authors.lastname: Musialik
authors.forename: B
authors.initials: B
authors.lastname: Raszeja-Wanic
authors.forename: J
authors.initials: J
authors.lastname: Głuszek
authors.forename: A
authors.initials: A
authors.lastname: Pieczyńska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D008297:Male; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D001613:beta 2-Microglobulin
vernacular_title: Wydalanie beta-2-mikroglobuliny w nadciśnieniu tetniczym.