title: Topoisomerases. In one gate, out the other.
abstract: The ability of type II DNA topoisomerases to pass one DNA double helix through another can be explained by a mechanism involving two gates in the enzyme structure.
authors.affiliation: Department of Biochemistry, University of Leicester, UK.
authors.forename: G
authors.initials: G
authors.lastname: Orphanides
authors.forename: A
authors.initials: A
authors.lastname: Maxwell
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000266:Adenylyl Imidodiphosphate / Q000378:metabolism; D004250:DNA Topoisomerases, Type II / Q000737:chemistry* / Q000378:metabolism*; D004278:DNA, Superhelical / Q000737:chemistry / Q000378:metabolism*; D008956:Models, Chemical; D015394:Molecular Structure; D013379:Substrate Specificity
chemical_list: D004278:DNA, Superhelical; D000266:Adenylyl Imidodiphosphate; D000255:Adenosine Triphosphate; D004250:DNA Topoisomerases, Type II