title: [Clinical studies on the treatment of coronary heart disease with Valeriana officinalis var latifolia].
abstract: Valeriana officinalis var latifolia (VOL), which is the variety of Valeriana officinalis and has the properties to relieve smooth muscle spasm and powerful vasodilation, as demonstrated by animal experiments; no report on its application in treating coronary heart disease (CHD) has been found as yet with VOL. Our preparation of a volatile oil fractionated from its root have been used to treat 82 CHD patients with angina pectoris, among whom ST-T ischemic changes appeared on ECG in 50 cases before treatment. Its total effective rate for the simple angina (without detectable ischemic findings) was 87.80%; the angina with ischemic findings, 88.00%. For comparisons, another 34 patients with the same conditions, 24 cases among them belonged to the angina with ischemic findings, were treated with a composite injection of Salvia miltiorrhiza (SMCo); the total effective rates for the simple angina and for the angina with ischemic findings were 41.18% and 37.50% respectively. The differences between VOL and SMCo were both highly significant (P < 0.001, P < 0.01) either in the simple angina or in the angina with ischemic findings. The results showed VOL was superior to SMCo on matter in the remission of symptoms, decreasing the attack frequency and shortening the duration of angina, or in restoring the blood supply to ischemic myocardium. In addition, it was discovered that VOL could lower plasma lipids as well. No toxic actions to liver, kidney, hemopoietic tissue, have been found.
authors.affiliation: Yunyang Medical College, Hubei Shiyan.
authors.forename: G Y
authors.initials: GY
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004365:Drugs, Chinese Herbal; D002784:Cholesterol