The effect of unilateral injury to the vas deferens on the contralateral testis in immature and adult rats.
The relationship between alterations in testicular histology and antisperm antibodies in immature and mature Lewis rats subjected to unilateral vasectomy was studied. Forty percent of immature rats and 90% of mature rats (p < 0.01) demonstrated significant alterations in both the obstructed (vasectomy) testis and the contralateral testis. There were significant changes in antisperm antibodies (ELISA) in the animals which demonstrated histologic changes.
Chehval
M J
MJ
Division of Urology, St. John's Mercy Medical Center, St. Louis, Missouri 63141-8277.
Martin
S A
SA
Alexander
N J
NJ
Winkelmann
T
T
D000367:Age Factors; D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D003251:Constriction, Pathologic; D004797:Enzyme-Linked Immunosorbent Assay; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D012671:Seminiferous Tubules / Q000473:pathology; D013094:Spermatozoa / Q000276:immunology; D013737:Testis / Q000473:pathology*; D014649:Vas Deferens / Q000293:injuries* / Q000473:pathology*; D014659:Vasectomy
D001323:Autoantibodies