title: 99Tcm-cystine, a renal function and imaging agent: a comparative study in dog with 131I-hippurate and 99Tcm-glucoheptonate to evaluate its functional and imaging characteristics.
abstract: 99Tcm-cystine, which has been proposed as a renal radiopharmaceutical for evaluating renal morphology and function in a single experiment, is compared with 131I-orthoiodohippurate (OIH) with respect to its renal clearance and extraction parameters and with 99Tcm-glucoheptonate (GHA) regarding its imaging characteristics. In spite of its comparable renal accumulation with 131I-OIH, its clearance (10.1 +/- 1.0 ml min-1 kg-1) was lower than that of 131I-OIH (21.5 +/- 0.9 ml min-1 kg-1) but was higher than that of 125I-iothalamate (5.4 +/- 0.6 ml min-1 kg-1). Extraction efficiencies of 99Tcm-cystine, 131I-OIH and 125I-iothalamate were 39 +/- 5, 64 +/- 4 and 27 +/- 3, respectively. The glomerular filtration components of 99Tcm-cystine and 131I-OIH were 26 and 16% of their respective clearances. In probenecid-treated animals the clearance of both agents was affected to a similar extent and fell to half of their respective control values, whereas tubular secretory components were found to be 19 and 31% of the controls. The kidney images obtained with 99Tcm-cystine were superior to those obtained with 99Tcm-GHA at different time points. Therefore, considering both renal function and imaging properties of 99Tcm-cystine it appears that this radiopharmaceutical offers some definite advantages over the currently available renal agents and commands further study.
authors.affiliation: Department of Nuclear Medicine, Indian Institute of Chemical Biology, Calcutta.
authors.forename: M
authors.initials: M
authors.lastname: Misra
authors.forename: H S
authors.initials: HS
authors.lastname: Sarkar
authors.forename: M
authors.initials: M
authors.lastname: Chakravarty
authors.forename: S
authors.initials: S
authors.lastname: Sanyal
authors.forename: S
authors.initials: S
authors.lastname: Ganguly
authors.forename: B R
authors.initials: BR
authors.lastname: Sarkar
authors.forename: J
authors.initials: J
authors.lastname: Chatterjee
authors.forename: P
authors.initials: P
authors.lastname: Dobe
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D003553:Cystine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004285:Dogs; D005260:Female; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007465:Iodohippuric Acid / Q000493:pharmacokinetics; D007668:Kidney / Q000000981:diagnostic imaging* / Q000502:physiology; D007677:Kidney Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008982:Molybdenum; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D011485:Protein Binding; D011877:Radionuclide Imaging; D013400:Sugar Acids / Q000493:pharmacokinetics
chemical_list: D001798:Blood Proteins; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D013400:Sugar Acids; C060718:technetium Tc 99m cystine; C044659:molybdate; D007465:Iodohippuric Acid; D003553:Cystine; D008982:Molybdenum; C100014:technetium Tc 99m gluceptate