Preparation for AIDS vaccine evaluation in Mombasa, Kenya: establishment of seronegative cohorts of commercial sex workers and trucking company employees.
In preparation for human immunodeficiency virus (HIV) prophylactic vaccine trials, prospective cohorts of HIV seronegative female commercial sex workers and male trucking company employees were established in Mombasa, Kenya, with the aims of defining HIV seroincidence and correlates of HIV seroconversion. Female and male cohorts were followed at 1- and 3-month intervals, respectively, with questionnaires, physical examinations, evaluation for sexually transmitted diseases, and HIV serologic testing. Between February and September, 1993, 1,277 women and 748 men were tested for antibodies to HIV-1. Seroprevalence was 55.4% among commercial sex workers and 17.7% among trucking company employees. Three hundred fifty-two HIV-seronegative women and 507 seronegative men were enrolled in the cohort studies. Annualized seroincidence rates of HIV infection were 16.4% (95% CI 8.8-27.0) among commercial sex workers and 6.6% (95% CI 2.5-13.8) among trucking company employees. These cohorts may be valuable resource for evaluating HIV vaccines and other potential preventive interventions.
Martin
H L
HL
Department of Medicine, University of Washington, Seattle.
Jackson
D J
DJ
Mandaliya
K
K
Bwayo
J
J
Rakwar
J P
JP
Nyange
P
P
Moses
S
S
Ndinya-Achola
J O
JO
Holmes
K
K
Plummer
F
F
D016915:AIDS Vaccines / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic / Q000379:methods; D015331:Cohort Studies; D005260:Female; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000453:epidemiology; D015528:HIV Seroprevalence; D015497:HIV-1; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009790:Occupations; D011446:Prospective Studies; D012309:Risk-Taking; D011477:Sex Work; D012749:Sexually Transmitted Diseases / Q000453:epidemiology; D014186:Transportation
D016915:AIDS Vaccines