title: Safety and optimum concentration of a manganese chloride-based oral MR contrast agent.
abstract: To determine the safety of a manganese chloride-based oral magnetic resonance (MR) contrast agent and the ideal concentration of the agent for marking in three different anatomic sites (stomach, middle of the small bowel, and ileocecal region), six healthy volunteers were evaluated before and after administration of 900 mL of three different concentrations of the contrast agent. Images were evaluated subjectively and objectively. No adverse events were noted. There was a minimal rise in manganese blood levels at 6 hours after administration, with a return to baseline at 24 hours. The imaging data demonstrated good-to-excellent bowel marking on T1-weighted images at all three concentrations. However, on T2-weighted images, the 40 mg Mn+2/L concentration provided improved hypointense bowel marking relative to the 20 mg/L concentration. Little difference was seen between the 40 and 60 mg/L concentrations. Fast T1- and T2-weighted sequences provided superior image quality to that of conventional spin-echo sequences.
authors.affiliation: Department of Radiology, Emory University Hospital, Atlanta, GA 30322.
authors.forename: M E
authors.initials: ME
authors.lastname: Bernardino
authors.forename: J C
authors.initials: JC
authors.lastname: Weinreb
authors.forename: D G
authors.initials: DG
authors.lastname: Mitchell
authors.forename: W C
authors.initials: WC
authors.lastname: Small
authors.forename: M
authors.initials: M
authors.lastname: Morris
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002432:Cecum / Q000033:anatomy & histology; D002712:Chlorides / Q000008:administration & dosage* / Q000009:adverse effects; D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects; D004338:Drug Combinations; D005998:Glycine; D006801:Humans; D007082:Ileum / Q000033:anatomy & histology; D007089:Image Enhancement; D007421:Intestine, Small / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000097:blood; D017895:Manganese Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D010368:Pectins / Q000008:administration & dosage / Q000009:adverse effects; D012449:Safety; D016037:Single-Blind Method; D019346:Sodium Acetate; D013270:Stomach / Q000033:anatomy & histology; D013395:Sucrose / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors
chemical_list: D002712:Chlorides; D003287:Contrast Media; D004338:Drug Combinations; C092198:LumenHance; D017895:Manganese Compounds; D008345:Manganese; D019346:Sodium Acetate; D013395:Sucrose; D010368:Pectins; C025340:manganese chloride; D005998:Glycine