Polymorphism of the murine inhibitor of differentiation-controlling gene, Id.
The structure of Id was examined by Southern analysis in inbred mouse lines which included five subspecies of Mus musculus. No variation was detected within this species. The species Mus cookii shares the same form found in mice of M. musculus derivation, indicative of a long evolutionary history and a common origin. However, five TaqI polymorphisms were found among several Mus species, suggesting that Id has been modified throughout species diversification. Whether these variants impart functional changes is yet to be determined.
Marlow
S A
SA
Department of Pathology, QE II Medical Centre, Nedlands, Western Australia.
Kay
P H
PH
Papadimitriou
J M
JM
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific; D018257:Helix-Loop-Helix Motifs / Q000235:genetics*; D051798:Inhibitor of Differentiation Protein 1; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009115:Muridae / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012097:Repressor Proteins; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C497455:Idb1 protein, mouse; D051798:Inhibitor of Differentiation Protein 1; D012097:Repressor Proteins; D014157:Transcription Factors; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases