title: Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.
abstract: The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: W J
authors.initials: WJ
authors.lastname: Grossman
authors.forename: J T
authors.initials: JT
authors.lastname: Kimata
authors.forename: F H
authors.initials: FH
authors.lastname: Wong
authors.forename: M
authors.initials: M
authors.lastname: Zutter
authors.forename: T J
authors.initials: TJ
authors.lastname: Ley
authors.forename: L
authors.initials: L
authors.lastname: Ratner
mesh_terms: D000818:Animals; D001483:Base Sequence; D002451:Cell Compartmentation; D015342:DNA Probes; D016355:Genes, pX; D053804:Granzymes; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D007942:Leukemia, Experimental / Q000235:genetics* / Q000821:virology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012697:Serine Endopeptidases / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D015342:DNA Probes; C509213:GZMB protein, human; D053804:Granzymes; C509214:Gzmb protein, mouse; D012697:Serine Endopeptidases