title: [Prevention of new cases of the disease in families of hemophilia patients in Moscow using a genetic register].
abstract: The genetic familial register in question contains information on 441 hemophilia patients. Two-thirds of the patients suffered from moderate or severe hemophilia, 81.3% had hemophilia A. Fifty-two families with the latter disease were examined with molecular methods which confirmed heterozygous carriage in 40% of the female examinees. The prenatal diagnosis in two families led to delivery of healthy boys. The genetic register provides effective protection for hemophiliac families.
authors.forename: O P
authors.initials: OP
authors.lastname: Pliushch
authors.forename: V L
authors.initials: VL
authors.lastname: Izhevskaia
authors.forename: E A
authors.initials: EA
authors.lastname: Likhacheva
mesh_terms: D005260:Female; D006580:Genetic Carrier Screening; D006467:Hemophilia A / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009031:Moscow / Q000453:epidemiology; D012042:Registries; D012307:Risk Factors
vernacular_title: Profilaktika povtornykh sluchaev zabolevaniia v sem'iakh bol'nykh gemofilieĭ v Moskve s ispol'zavaniem geneticheskogo registra.