title: Uteroplacental and fetal haemodynamics and cardiac function of the fetus and newborn after crystalloid and colloid preloading for extradural caesarean section anaesthesia.
abstract: We have studied the effects of randomized preloading with either a crystalloid (lactated Ringer's) 15 ml kg-1 or colloid (hydroxyethyl starch) 7.5 ml kg-1 solution in 20 parturients undergoing elective Caesarean section under extradural anaesthesia, on blood flow in maternal placental and non-placental uterine and placental arcuate arteries and in fetal umbilical, renal and middle cerebral arteries, using a pulsed colour Doppler technique. Simultaneously, fetal and neonatal myocardial function were investigated by pulsed Doppler and M-mode echocardiography. We found no changes in maternal or fetal blood velocity waveform indices after crystalloid preloading, but the pulsatility index of the maternal non-placental uterine artery increased significantly after colloid preloading. Fetal heart rate decreased after preloading with crystalloid solution. There were no differences in fetal or neonatal myocardial function between the groups, and the outcome of the newborn infants were uneventful in all cases. These results suggest that preloading with either a crystalloid or colloid solution may lead to different uterine and fetal haemodynamics but these solutions had only minimal effects on fetal and neonatal myocardial performance and no effect on the clinical condition of newborns in uncomplicated pregnancies.
authors.affiliation: Department of Anaesthesia, Oulu University Central Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Karinen
authors.forename: J
authors.initials: J
authors.lastname: Räsänen
authors.forename: T
authors.initials: T
authors.lastname: Paavilainen
authors.forename: S
authors.initials: S
authors.lastname: Alahuhta
authors.forename: R
authors.initials: R
authors.lastname: Jouppila
authors.forename: P
authors.initials: P
authors.lastname: Jouppila
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002536:Cerebral Arteries / Q000502:physiology; D002585:Cesarean Section; D003102:Colloids / Q000627:therapeutic use*; D005260:Female; D005333:Fetus / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006340:Heart Rate, Fetal / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007552:Isotonic Solutions / Q000627:therapeutic use*; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D011256:Pregnancy Outcome; D000077325:Ringer's Lactate; D014469:Umbilical Arteries / Q000502:physiology; D014599:Uterus / Q000098:blood supply
chemical_list: D003102:Colloids; D007552:Isotonic Solutions; D000077325:Ringer's Lactate