title: Detection of 1-acetamino-3-(1-naphthyloxy)-2-propanol as a new metabolite of propranolol.
abstract: 1-Acetamino-3-(1-naphthyloxy)-2-propanol which is an acetyl conjugate of N-desisopropylpropranolol (AcNDP) was detected as a new metabolite of propranolol (PL) from the incubation medium of isolated rat hepatocyte system and from the urinary extracts of a patient under PL therapy as well as a healthy volunteer given PL. In the case of the hepatocyte systems, the optical selectivity of PL elimination and the metabolite formation were discussed by HPLC determination, and the effect of pretreatment by phenobarbital (PB) or 3-metylcholanthrene (3-MC) on the metabolism was also clarified.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Noda
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
authors.forename: K
authors.initials: K
authors.lastname: Inokuchi
authors.forename: S
authors.initials: S
authors.lastname: Eto
authors.forename: H
authors.initials: H
authors.lastname: Noda
authors.forename: H
authors.initials: H
authors.lastname: Muro
authors.forename: T
authors.initials: T
authors.lastname: Uchida
mesh_terms: D000081:Acetamides / Q000378:metabolism* / Q000652:urine; D000368:Aged; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008875:Middle Aged; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology; D011412:Propanolamines / Q000378:metabolism* / Q000652:urine; D011433:Propranolol / Q000378:metabolism* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: C092336:1-acetamino-3-(1-naphthyloxy)-2-propanol; D000081:Acetamides; D011412:Propanolamines; D008748:Methylcholanthrene; D011433:Propranolol; D010634:Phenobarbital