[The effect of the immunomodulator neurotropin on the learning of active defensive behavior by rats].
Rats were intraperitoneally injected with neurotropin (NSP), a substrate extracted from the inflammatory dermis of rabbits inoculated with Vaccine virus. Active avoidance behaviour of rats was studied. After NSP administration rats demonstrated higher levels of conditioning and true responses compared with control. In NSP-treated rats relationship between the time of beginning of intersignal run during learning and success of the avoidance trial differed from that in the control group. The results suggest that neurotropin administration activates the retrieval processes and leads to stronger consolidation of avoidance behaviour.
Murtazina
E P
EP
Zhuravlev
B V
BV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012054:Reinforcement, Psychology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C010491:neurotropin
Vliianie immunomoduliatora neĭrotropina na obuchenie krys aktivno-oboronitel'nomu povedeniiu.