title: Primate antibodies to components of the human immune system.
abstract: The feasibility to raise nonhuman primate antibodies against selected components of the human immune system was tested. The immunogens were whole cells (human T lymphocytes) or purified, recombinant human proteins (cytokines: TNF alpha or GM-CSF; soluble forms of cell surface antigens: sCD4 or sCD25). Significant immunizations, yielding functionally relevant antibodies, were readily achieved in rhesus monkeys, but, not surprisingly, may be less frequent in chimpanzees. The results suggest a general strategy for production of therapeutically useful MAB.
authors.affiliation: Monoclonal Antibody Research, Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
authors.forename: L
authors.initials: L
authors.lastname: Lögdberg
authors.forename: E
authors.initials: E
authors.lastname: Kaplan
authors.forename: M
authors.initials: M
authors.lastname: Drelich
authors.forename: E
authors.initials: E
authors.lastname: Harfeldt
authors.forename: H
authors.initials: H
authors.lastname: Gunn
authors.forename: P
authors.initials: P
authors.lastname: Ehrlich
authors.forename: D
authors.initials: D
authors.lastname: Dottavio
authors.forename: P
authors.initials: P
authors.lastname: Lake
authors.forename: L
authors.initials: L
authors.lastname: Ostberg
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D000917:Antibody Formation; D015703:Antigens, CD / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology; D015186:Hominidae / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000096:biosynthesis; D008253:Macaca mulatta / Q000276:immunology; D002679:Pan troglodytes / Q000276:immunology; D010215:Papio / Q000276:immunology; D011323:Primates / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015704:CD4 Antigens; D016207:Cytokines; D007074:Immunoglobulin G; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor