[Antioxidant and antiradical activity of various classes of antioxidants].
Antiradical and antioxidative activities of classic phenolic antioxidants and blockers of Ca(2+)-channel have been studied. K2 rate constants and pI50 concentrations of tested physiologically active substances have been determined. Using the model systems of hepatic microsomal membranes lipoperoxidation it is shown that there is no distinct correlation between the antiradical and antioxidative activities of substances under investigation. These results have shown a necessity of complex evaluation of antioxidant properties of pharmacological drugs.
Gubskiĭ
Iu I
IuI
Litvinova
N V
NV
Shnurko-Tabakova
E V
EV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D016166:Free Radical Scavengers; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D015227:Lipid Peroxidation; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D002121:Calcium Channel Blockers; D016166:Free Radical Scavengers; D010636:Phenols
Antiokislitel'naia i antiradikal'naia aktivnost' antioksidantov razlichnykh klassov.