[Significance of cyclic nucleotides in pathogenesis of cor pulmonale in tuberculosis of respiratory organs and the use of beta adrenoblockers].
Blood levels of cyclic nucleotides and their actions on central hemodynamics were studied in 129 patients with pulmonary tuberculosis. A direct correlation was established between heart rate, pulmonary artery systolic pressure and concentrations of cyclic adenosine monophosphate. Basing on this finding, the authors propose introduction of beta-adrenoblockers in hyperkinetic circulation tuberculous patients to prevent cor pulmonale. Administration of anapriline in tuberculous patients with compensated cor pulmonale and symptoms of sympathoadrenal hyperfunction improves the patients' condition, promotes a decrease in cardiac output, cardiac index, systolic pressure in the pulmonary artery. No side effects of the drug were reported.
Ershov
A I
AI
Tikhonov
V A
VA
Evstaf'ev
Iu A
IuA
Sharunov
S I
SI
Grigaliunas
A P
AP
Rodina
I N
IN
D000328:Adult; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000009:adverse effects / Q000627:therapeutic use*; D011660:Pulmonary Heart Disease / Q000209:etiology* / Q000517:prevention & control; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications* / Q000503:physiopathology
D011433:Propranolol; D000242:Cyclic AMP; D006152:Cyclic GMP
Znachenie tsiklicheskikh nukleotidov v patogeneze legochnogo serdtsa pri tuberkuleze organov dykhaniia i primenenii beta-adrenoblokatorov.