Paracoccidioides brasiliensis-stimulated human gamma/delta T cells support antibody production by B cells.
Paracoccidioidomycosis patients show hyperactive humoral immune responses. Consequently, we investigated whether cytokines in supernatants from Paracoccidioides brasiliensis-stimulated gamma/delta T cells support B-cell activation. We detected proliferation of B cells and increased immunoglobulin M (IgM) and IgG production. Thus, gamma/delta T cells may participate in polyclonal B-cell activation during paracoccidioidomycosis.
Munk
M E
ME
Department of Immunology, University of Ulm, Germany.
Fazioli
R A
RA
Calich
V L
VL
Kaufmann
S H
SH
D000908:Antibodies, Fungal / Q000096:biosynthesis; D000917:Antibody Formation; D000946:Antigens, Fungal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D010228:Paracoccidioides / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D016692:Receptors, Antigen, T-Cell, gamma-delta