Adverse interaction between warfarin and indomethacin.
A 57-year-old man developed spontaneous skin bruising and haematuria during combined therapy with warfarin and indomethacin. Due to the potential effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the anticoagulant action of warfarin and platelet function, patients receiving both warfarin and NSAIDs should have their prothrombin time monitored very closely. Also, the risk of gastrointestinal haemorrhage with any NSAIDs must always be remembered.
Chan
T Y
TY
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T.
Lui
S F
SF
Chung
S Y
SY
Luk
S
S
Critchley
J A
JA
D004347:Drug Interactions; D006073:Gout / Q000188:drug therapy; D006417:Hematuria / Q000139:chemically induced*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013924:Thrombophlebitis / Q000188:drug therapy; D014859:Warfarin / Q000009:adverse effects* / Q000627:therapeutic use
D014859:Warfarin; D007213:Indomethacin