title: [Development of novel elastomeric surgical adhesive: biomechanical and pathohistological heeling process].
abstract: A newly developed novel elastometric surgical elastoma based on reactive hydrophylic urethane was tested in vivo experiment of dog models for its anastomotic performances and functions at various periods. The carotid artery as well as the abdominal aorta were completely transected and reanastomosed by applying the adhesive materials. The serial studies on patency rate, tensile strength, elasticity as well as histopathological examinations were undertaken up to the longest period of 180 days after the implantation. The overall patency rate in carotid anastomosis was 93.9%, where in the abdominal aorta, 100% of patency rate was obtained. The tensile strength at the anastomosis surpassed the stress derived from pulsation and internal tension within 7 days of implantation. No significant change in stiffness parameter beta was observed in 180 days of implantation. Histopathological studies at the site of anasotmosis revealed the presence of mild inflammatory reaction in earlier phase and well healing of tissue without foreign body reaction in later period. This material proved to be an effective surgical adhesive in reference to the compliance mateching so as to facilitate to expect for the clinical application in cardiovascular surgical practice.
authors.affiliation: First Department of Surgery, Chiba University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology* / Q000601:surgery; D001696:Biomechanical Phenomena; D002339:Carotid Arteries / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D004548:Elasticity; D012408:Rubber; D013718:Tensile Strength; D014014:Tissue Adhesives; D014520:Urethane; D014654:Vascular Patency; D014945:Wound Healing
chemical_list: D014014:Tissue Adhesives; D014520:Urethane; D012408:Rubber