[Single calcium channel analysis and electron spin resonance (ESR) spectral study on the myocardial effects of ginsenoside Rb2].
Based on the patch clamp technique, the effect of ginsenoside Rb2 on the single channel activity of Ca2+ was observed through the single ventricular myocytes of Wistar rats. Electron spin resonance was used to measure the free radical contents of cultured cardiomyocytes. It is proved that Rb2 can inhibit the activities of single calcium channel and significantly antagonize the increase of free radical contents induced by xanthine-xanthine oxidase.
Wang
X M
XM
Jilin Institute of Medical Industry, Changchun.
Qi
Y
Y
Sun
C W
CW
Zhong
G G
GG
Jiang
Y
Y
Qiu
Y H
YH
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects*; D002478:Cells, Cultured; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000378:metabolism; D036145:Ginsenosides; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D005894:Panax; D018408:Patch-Clamp Techniques; D010946:Plants, Medicinal; D051381:Rats; D012503:Saponins / Q000494:pharmacology*
D015220:Calcium Channels; D005609:Free Radicals; D036145:Ginsenosides; D012503:Saponins; C048026:ginsenoside Rb2