Platelet 5-HT uptake sites, labelled with [3H] paroxetine, in controls and depressed patients before and after treatment with fluoxetine or lofepramine.
Platelet [3H] paroxetine binding was measured in 73 depressed patients and in 64 healthy volunteers. No differences were found in Bmax or Kd either overall, or when the 61 depressed subjects who had never received psychotropic drugs were analysed separately. Within the depressed group, no differences in Bmax or Kd were found between subgroups divided on the basis of endogenicity, suicidal thoughts or severity of depression. None of the subgroups differed significantly from controls. Forty of the depressed subjects were retested after 6 weeks' treatment with fluoxetine (n = 22) or lofepramine (n = 18). Treatment was not associated with any change in Bmax but a similar and significant increase in Kd was noted following treatment with either antidepressant. Neither pre- nor post-treatment platelet binding parameters appeared to relate to clinical response to treatment.
Lawrence
K M
KM
Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.
Katona
C L
CL
Abou-Saleh
M T
MT
Robertson
M M
MM
Nairac
B L
BL
Edwards
D R
DR
Lock
T
T
Burns
R A
RA
Harrison
D A
DA
Horton
R W
RW
D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D008127:Lofepramine / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*
D011985:Receptors, Serotonin; D005473:Fluoxetine; D017374:Paroxetine; D008127:Lofepramine