title: Ultraviolet-B irradiation alters cytokine production by immune lymphocytes in herpes simplex virus-infected mice.
abstract: Previous studies from our laboratories have shown that UV-B irradiation at the site of an intradermal infection of herpes simplex virus (HSV) resulted in a higher incidence of zosteriform lesions and suppressed cellular immune responses to HSV in mice. In order to determine whether the production of T-cell-derived cytokine (IFN-gamma, IL-2 and IL-4) by immune cells from irradiated mice is also suppressed, we examined the production of cytokines by lymph node cells and spleen cells taken from UV-B irradiated, HSV type 1 (HSV-1)-infected mice. UV-B irradiation (120 mJ/cm2) prior to HSV-1 infection was found to markedly suppress IFN-gamma production compared to that of the non-irradiated control. IL-4 production was enhanced compared to IL-2 in the UV-B irradiated mice. These results suggest that alteration(s) in the cytokine production profile may therefore be involved in the development of severe skin lesions caused by HSV infection in UV-B irradiated mice.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yasumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Moroi
authors.forename: T
authors.initials: T
authors.lastname: Koga
authors.forename: I
authors.initials: I
authors.lastname: Kawamura
authors.forename: M
authors.initials: M
authors.lastname: Mitsuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Hori
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology / Q000494:pharmacology; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis* / Q000502:physiology; D005260:Female; D006561:Herpes Simplex / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular / Q000528:radiation effects; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology / Q000528:radiation effects; D008213:Lymphocyte Activation / Q000528:radiation effects; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000528:radiation effects; D051379:Mice; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000276:immunology / Q000502:physiology; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000956:Antigens, Viral; D016207:Cytokines; D007376:Interleukin-2; D015847:Interleukin-4; D007371:Interferon-gamma