Supernumerary isochromosome 4p in ANLL-M4 myelomonocytic type is associated with favorable prognosis.
A case of an acute non-lymphocytic leukemia of M4 type with a supernumerary isochromosome (4p) in 100% of the initial bone marrow metaphase cells is reported. The origin of the extra chromosome is verified by the fluorescence in situ hybridization technique using a whole chromosome 4 painting probe. A possible favorable prognosis of the ANLL-M4 case showing a supernumerary isochromosome (4p) is cautiously emphasized.
Hoo
J J
JJ
Rush Medical Laboratory, Rush Cancer Institute, Division of Hematology & Oncology/Department of Medicine, Chicago, Illinois.
Gregory
S A
SA
Jones
B
B
Szego
K
K
D002894:Chromosomes, Human, Pair 4; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018404:Isochromosomes; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000503:physiopathology; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis