Neuroglial-specific factors and the regulation of retrovirus transcription.
Retroviruses have been implicated as causative agents of a variety of human diseases including malignancy, immune system dysfunction, and neurologic disorders. Despite the isolation of various retroviral agents from patients suffering from malignant neoplasias and neurologic disorders, only the human T-cell lymphotropic virus type I (HTLV-I) and the human immunodeficiency virus (HIV) have been definitively accepted as etiologic agents of human disease (Hjelle, 1991; Gessain and Gout, 1992; Rosenblatt, 1993). Because of their increasingly defined roles in disease progression, the replication of HTLV-I and HIV is an important focus for understanding the pathogenic processes resulting from viral infection. Of particular interest are the molecular mechanisms by which expression of retroviral genomes is regulated by their regulatory units, the long terminal repeats (LTR), in a manner specific to the cellular targets which they infect.
Tillmann
M
M
Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey 17033.
Krebs
F C
FC
Wessner
R
R
Pomeroy
S M
SM
Goodenow
M M
MM
Wigdahl
B
B
D015526:AIDS Dementia Complex / Q000473:pathology / Q000821:virology; D001483:Base Sequence; D002478:Cells, Cultured; D015967:Gene Expression Regulation, Viral; D016356:Gene Products, tax / Q000502:physiology; D016679:Genome, Viral; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000502:physiology*; D015368:Human T-lymphotropic virus 1 / Q000502:physiology*; D006801:Humans; D017628:Microglia / Q000502:physiology / Q000821:virology; D008954:Models, Biological; D008969:Molecular Sequence Data; D009457:Neuroglia / Q000502:physiology* / Q000821:virology; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D016356:Gene Products, tax; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors