title: Effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid consumption in the rat.
abstract: Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in water). The increase in fluid consumption induced with zolpidem was comparable to the increases observed with diazepam and the benzodiazepine partial agonist, FG 8205. Experiment 2 demonstrated that this zolpidem-induced increase in drinking could be observed in both naive rats and in rats that had been habituated to the glucose drink and the testing environment: pretreatment with 3.0 mg/kg PO of zolpidem was found to increase fluid consumption in rats that had received either 0 or 8 days pre-exposure to the testing conditions. Contrary to earlier reports, these results support the conclusion that zolpidem, like other benzodiazepine agonists, can directly modulate ingestive behaviour.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, UK.
authors.forename: K J
authors.initials: KJ
authors.lastname: Stanhope
authors.forename: S
authors.initials: S
authors.lastname: Roe
authors.forename: G
authors.initials: G
authors.lastname: Dawson
authors.forename: F
authors.initials: F
authors.lastname: Draper
authors.forename: A
authors.initials: A
authors.lastname: Jackson
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001007:Anxiety / Q000523:psychology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects*; D004777:Environment; D058785:GABA-A Receptor Agonists; D005947:Glucose / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D009042:Motivation; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D000077334:Zolpidem
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D058785:GABA-A Receptor Agonists; D006993:Hypnotics and Sedatives; D011725:Pyridines; C063822:L 663581; D001569:Benzodiazepines; D000077334:Zolpidem; D005947:Glucose