title: [Uterine reactions to prostaglandins in induced labor--results of a multicenter study].
abstract: During a prospective multicentric study concerning labor induction with prostaglandins 1472 prostaglandin-inductions were documented. With a Bishop Score < 5 a gel containing 0.5 mg of PgE2 was applied intracervically, with a Bishop Score > = 5 a tablet containing 3 mg of PgE2 was applied retrocervically inside vagina. In case of lacking success the application was repeated after 6 to 8 hours and after 24 hours according to the actual Bishop-Score. Coordinated labor after application of PG-gel or PG-tablet was observed in 85.2% (83.3% respectively), polycystolia or tetani in 13.9% of cases (9.1% respectively). Differences were not statistically significant. Uterine reactions started in the mean 5-6 hours after the last PG-application, but intervals showed a significant spreading among single cases. In 16.0% of the patients successfully treated with Pg-gel and in 8.3% of the patients successfully treated with a PG-tablet due to a uterine hyperstimulation a tocolytic treatment became necessary. With a ripe cervical score (Bishop-Score > 7 points) a significant shortening of the induction-interval was observed.
authors.affiliation: Universitätsfrauenklinik, Homburg/Saar, Bundesrepublik Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Mink
authors.forename: C
authors.initials: C
authors.lastname: Heiss
authors.forename: W
authors.initials: W
authors.lastname: Rath
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D002585:Cesarean Section; D015232:Dinoprostone / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005782:Gels; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced / Q000379:methods*; D011247:Pregnancy; D011446:Prospective Studies; D013607:Tablets; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D005782:Gels; D013607:Tablets; D015232:Dinoprostone
vernacular_title: Uterine Reaktionen auf Prostaglandine zur Geburtseinleitung--Ergebnisse einer Multizenterstudie.