Blockade of ethanol discrimination by isradipine.
The effect of the dihydropyridine Ca2+ channel antagonist, isradipine, on ethanol discrimination was assessed in rats trained to discriminate 1.5 g/kg ethanol from water in a T-maze, food-reinforced drug discrimination procedure. Pretreatment with isradipine (0, 1.0, 3.0 and 5.0 mg/kg i.p.) resulted in a dose-dependent blockade of ethanol discrimination. The results of the present study suggest that L-type Ca2+ channels are involved in the mediation of ethanol discriminative stimulus effects.
Colombo
G
G
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Agabio
R
R
Lobina
C
C
Reali
R
R
Fadda
F
F
Gessa
G L
GL
D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects; D000431:Ethanol / Q000037:antagonists & inhibitors*; D017275:Isradipine / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051381:Rats; D014867:Water
D014867:Water; D000431:Ethanol; D017275:Isradipine