title: Intracranial metyrapone stimulates CRF-ACTH axis in the teleost, Clarias batrachus: possible role of neurosteroids.
abstract: Intracranial administration of metyrapone, a blocker of the enzyme 11-beta-hydroxylase, which is essential for the biosynthesis of corticosteroids, resulted in profound stimulation of the nucleus preopticus and the CRF-ACTH axis in the teleost, Clarias batrachus. It is suggested that the putative blockade of the neurosteroid biosynthesis following metyrapone might be responsible for this action. The present study for the first time uncovers the possibility of inhibitory regulation of the CRF-ACTH axis by metyrapone sensitive neurosteroids.
authors.affiliation: Department of Pharmaceutical Sciences, Nagpur University, India.
authors.forename: M R
authors.initials: MR
authors.lastname: Jain
authors.forename: F A
authors.initials: FA
authors.lastname: Khan
authors.forename: N S
authors.initials: NS
authors.lastname: Krishna
authors.forename: N
authors.initials: N
authors.lastname: Subhedar
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002397:Catfishes / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D005260:Female; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D013256:Steroids / Q000502:physiology*; D013268:Stimulation, Chemical
chemical_list: D013256:Steroids; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D008797:Metyrapone