[Pyridoxine neuropathies. Review of the literature].
Daily needs of vitamin B6 are very low (2 mg per day) and widely covered by normal feeding. Pyridoxine deficiencies are exceptional (congenital metabolic abnormalities, drug or toxic-induced perturbations). First described in animal models, human cases of neuropathy had been encountered in the "megavitamin"-syndrome. They are confirmed by rare case-reports of very high doses given in toxic indication. Sensory peripheral neuropathies can also occur with lower doses taken over a long period of time.
Dordain
G
G
Service de Neurologie, CHU de Clermont-Ferrand, Hôpital Nord, Clermont-Ferrand.
Deffond
D
D
D000328:Adult; D000818:Animals; D004285:Dogs; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D011736:Pyridoxine / Q000008:administration & dosage / Q000378:metabolism / Q000506:poisoning*; D051381:Rats
D011736:Pyridoxine
Neuropathies à la pyridoxine. Revue de la littérature.