Low-molecular-weight (tubular) proteinuria is not related to glycaemic control in non-insulin dependent diabetes mellitus.
Early morning urine specimens were obtained from two groups of non-insulin dependent diabetic patients and a group (43 subjects) of normal controls. The diabetic patients were divided into two subgroups according to the degree of diabetic control as judged by their glycosylated haemoglobin (HbA1) levels (well-controlled, 47 subjects; poorly controlled, 51 subjects). The concentration of the low-molecular-weight enzyme (lysozyme) was determined in each urine specimen and related to the concentration of creatinine (lysozyme/creatinine). The mean urinary lysozyme concentration was higher in each of the two diabetic groups as compared with the control group. However, it was not significantly different between the two diabetic groups. These result suggest that there is no association between the degree of glycaemic control and tubular proteinuria.
al-Kassab
A S
AS
Department of Clinical Biochemistry, College of Medicine, Abha, Saudi Arabia.
Makeen
A
A
Wardle
E N
EN
Quwasmah
A R
AR
Nasr
M A
MA
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000652:urine*; D003928:Diabetic Nephropathies / Q000652:urine*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000652:urine; D011507:Proteinuria / Q000652:urine*
D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D009113:Muramidase