T lymphocytes and immunosuppression in the burned patient: a review.
Extensive thermal trauma results in impaired immune function which has been attributed to a reduction in T lymphocyte numbers, increased suppressor cell activity, serum suppressive factors and altered cytokine synthesis and receptor expression on T cells. Numeric and phenotypic changes in T lymphocytes, T cell proliferation and functional responses of T lymphocytes in recent studies using murine models and patients are described.
Barlow
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Vital Signs Consultants, Sawston, Cambridge, UK.
D000818:Animals; D002056:Burns / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007108:Immune Tolerance; D016867:Immunocompromised Host / Q000276:immunology / Q000502:physiology; D008231:Lymphopenia; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology