title: Effects of fit and bonding characteristics of femoral stems on adaptive bone remodeling.
abstract: Bone atrophy caused by stress-shielding may cause serious complications for the long-term fixation of hip stems. In particular, uncemented total hip arthroplasty is threatened by this problem, because the stems are usually larger and, as a consequence, stiffer than those of cemented implants. In the present study, the effects of fit and bonding characteristics of femoral hip stems were investigated, using the (nonlinear) finite element method in combination with adaptive bone remodeling theory to predict the bone density distribution in a bone or bone/implant configuration. Unknown parameters used in the theory, such as a reference equilibrium loading stimulus and a threshold (dead) zone of this stimulus, were established (triggered) by using the method to predict the density distributions in the natural femur and around fully coated uncemented implants. The computer simulation method can provide long term predictions of remodeling patterns around various implant configurations. Several cases were analyzed, whereby the coating conditions (fully, partly, or noncoated) and the fit characteristics (press fitted or overreamed) were varied. The computer predictions showed that partly coating can only significantly reduce bone atrophy relative to fully coated stems, when the coating is applied at a small region at the utmost proximal part of the stem. For smooth press-fit stems the predicted amount of bone loss (35 percent in the proximal medial region) was less than for a one-third proximally coated or a fully coated stem (50 to 54 percent predicted bone loss in the proximal medial region).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Section of Biomechanics, University of Nijmegen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Weinans
authors.forename: R
authors.initials: R
authors.lastname: Huiskes
authors.forename: H J
authors.initials: HJ
authors.lastname: Grootenboer
mesh_terms: D000222:Adaptation, Physiological; D001284:Atrophy; D001696:Biomechanical Phenomena; D001843:Bone Cements; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D003198:Computer Simulation; D005069:Evaluation Studies as Topic; D005269:Femur / Q000473:pathology / Q000503:physiopathology*; D006622:Hip Prosthesis; D006801:Humans; D017711:Nonlinear Dynamics; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D017755:Prosthesis Fitting
chemical_list: D001843:Bone Cements