title: Pharmacokinetics of cyclophosphamide in patients with systemic necrotizing angiitis.
abstract: Cyclophosphamide pharmacokinetics were investigated following administration to patients with systemic necrotizing angiitis. Ten patients (eight women and two men) received cyclophosphamide as a 1-h-rate-constant intravenous infusion at doses ranging from 600 to 1200 mg. All patients received concomitant oral prednisone (1 mg/kg/d). Blood samples were collected at the end of drug infusion and 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24 h later. Serum cyclophosphamide concentrations were assayed by high pressure liquid chromatography. The peak serum cyclophosphamide levels ranged from 15.7 to 29.4 mg/L. The mean cyclophosphamide elimination half-life was 6.2 +/- 1.3 h (mean +/- SD). The mean apparent volume of distribution and mean total plasma clearance were, respectively, 0.75 +/- 0.22 L/kg (mean +/- SD) and 83 +/- 22 mL/min (mean +/- SD). These results obtained in systemic vasculitic diseases were consistent with those observed in other studies with cancer patients receiving comparable doses of cyclophosphamide.
authors.affiliation: Laboratoire de Pharmacie Clinique, CHI Montfermeil, France.
authors.forename: L
authors.initials: L
authors.lastname: Belfayol
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
authors.forename: K
authors.initials: K
authors.lastname: Louchahi
authors.forename: P
authors.initials: P
authors.lastname: Perrin
authors.forename: P
authors.initials: P
authors.lastname: Cherrier
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
authors.forename: A M
authors.initials: AM
authors.lastname: Bosio
authors.forename: F
authors.initials: F
authors.lastname: Fauvelle
mesh_terms: D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D014657:Vasculitis / Q000378:metabolism* / Q000473:pathology
chemical_list: D003520:Cyclophosphamide