Diamine-oxidase activity and tissue di- and poly-amine contents of human ovarian, cervical and endometrial carcinoma.
In view of the conflicting reports regarding the association of di- and poly-amines along with diamine oxidase (DAO) activity in human carcinomatous growths, the present study was undertaken to establish their interrelation and to justify whether analysis of di- and poly-amine contents along with DAO may have any diagnostic value in the assessment of the carcinomatous state. It was found that diamines like histamine, putrescine and cadaverine, and polyamines like spermine and spermidine, and also DAO, increased unequivocally in human ovarian, cervical and endometrial carcinoma in comparison with their adjoining normal tissues. A reasonable explanation has been put forward to support the observations made.
Chanda
R
R
Department of Physiology, University College of Medicine, Calcutta, India.
Ganguly
A K
AK
D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D015317:Biogenic Polyamines / Q000378:metabolism*; D002103:Cadaverine / Q000378:metabolism; D003959:Diamines / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006632:Histamine / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D012016:Reference Values; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000201:enzymology / Q000378:metabolism*
D015317:Biogenic Polyamines; D003959:Diamines; D013096:Spermine; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D002103:Cadaverine; D013095:Spermidine; D011700:Putrescine