Fertility in patients treated with radiotherapy following orchidectomy for testicular seminoma.
This study evaluated the effect of paraaortic and ipsilateral pelvic node irradiation on the fertility of a group of 50 patients with Stage I and II testicular seminoma. Eleven patients were infertile before the start of treatment, and another 23 were unable or unwilling to father a child after radiotherapy. From the remaining 16 patients, 11 pregnancies resulted. It has been shown that fertility can be preserved if the dose to the remaining testis can be reduced to less than 2 Gy. No genetic abnormalities were seen in the offspring of any patient.
Malas
S
S
University of Witwatersrand, Johannesburg, South Africa.
Levin
V
V
Sur
R K
RK
Donde
B
B
Krawitz
H E
HE
Pacella
J A
JA
D000328:Adult; D000368:Aged; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000517:prevention & control; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009919:Orchiectomy; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012189:Retrospective Studies; D018239:Seminoma / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery*; D013736:Testicular Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*