Accumulation of natural killer cells after hepatic artery embolisation in the midgut carcinoid syndrome.
Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients.
Wängberg
B
B
Department of Surgery, Sahlgrenska Hospital, Gothenburg, Sweden.
Ahlman
H
H
Tylén
U
U
Nilsson
O
O
Hermodsson
S
S
Hellstrand
K
K
D003602:Cytotoxicity, Immunologic; D004621:Embolization, Therapeutic; D006499:Hepatic Artery; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology* / Q000628:therapy*; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology / Q000556:secondary* / Q000628:therapy*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008303:Malignant Carcinoid Syndrome / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D010641:Phenotype