title: Antagonistic effects of antipamezole on medetomidine-midazolam induced sedation in dogs.
abstract: Antagonistic effect of atipamezole (80 micrograms/kg) on medetomidine (20 micrograms/kg)-midazolam (0.3 mg/kg) induced sedation was evaluated in dogs. Atipamezole effectively reversed sedation and significantly shortened arousal time and total recovery time without apparent side effects. Atipamezole also effectively reversed changes in heart rate, respiratory rate and body temperature produced by medetomidine-midazolam. The possible use of atipamezole as a reversal agent might enhance the value and availability of medetomidine-midazolam for a chemical restraint agent in dogs.
authors.affiliation: Department of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: R
authors.initials: R
authors.lastname: Nishimura
authors.forename: A
authors.initials: A
authors.lastname: Yamaki
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: A
authors.initials: A
authors.lastname: Takeuchi
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D020926:Medetomidine; D008874:Midazolam / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
chemical_list: D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C050701:atipamezole; D020926:Medetomidine; D008874:Midazolam