title: One year experience of elderly hypertensive patients with isradipine therapy.
abstract: This is the first report of long-term use (one year) of isradipine, a new dihydropyridine calcium channel blocker, in the treatment of elderly patients with essential hypertension. Patients completing a three month, double-blind, multicentre study comparing isradipine to hydrochlorothiazide (HCTZ) were eligible to enroll in this open-label, continuation study. At initial baseline, patients were at least 60 years of age and had DBP from 95 mmHg to 120 mmHg. Patients were titrated when necessary every two weeks with isradipine, 5 mg to 15 mg once daily or 2.5 mg to 10 mg twice daily, to maintain sitting DBP < or = 90 mmHg. HCTZ, 12.5 mg to 50 mg once daily, could be added for better BP control. A total of 136 patients completed the one year, open-label phase. One hundred and fourteen patients (84%) received isradipine as monotherapy (mean dose, 9.7 mg/day); 22 received concomitant HCTZ therapy at one year. Reduction in DBP was significant and similar among all age groups and races (mean change of -19 mmHg). Reduction in SBP was similar among all age groups. Ninety-four per cent of those receiving isradipine monotherapy achieved BP control during the last four months of treatment. Twenty-six patients (16%) withdrew from the study: 11 (7%) had adverse reactions (one with headache, two with pedal oedema, eight with other problems); 11 (7%) had nondrug-related problems; and in four (2%), the drugs were ineffective. Based on these observations, isradipine is a well-tolerated, safe and effective agent for long-term BP control in elderly patients with essential hypertension.
authors.affiliation: Veterans Affairs Medical Center, Gainesville, FL.
authors.forename: G H
authors.initials: GH
authors.lastname: Stein
authors.forename: B P
authors.initials: BP
authors.lastname: Hamilton
authors.forename: J H
authors.initials: JH
authors.lastname: Hamilton
authors.forename: J L
authors.initials: JL
authors.lastname: Holtzman
authors.forename: W M
authors.initials: WM
authors.lastname: Kirkendall
authors.forename: A
authors.initials: A
authors.lastname: Abrams
authors.forename: G
authors.initials: G
authors.lastname: Neri
authors.forename: R
authors.initials: R
authors.lastname: Culter
authors.forename: K
authors.initials: K
authors.lastname: Matthews
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D017275:Isradipine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010352:Patient Dropouts
chemical_list: D006852:Hydrochlorothiazide; D017275:Isradipine