Confirmational analysis of beta-agonists by cryotrapping gas chromatography-Fourier transform infrared spectrometry.
Cryotrapping gas chromatography-Fourier transform infrared spectrometry has been used for confirmation analysis of the beta-agonists clenbuterol, salbutamol, mabuterol, bromobuterol, cimaterol, cimbuterol and mapenterol in urine and liver samples of veal calves, subsequent to selected ion detection gas chromatography-mass spectrometry. Samples have been analysed as their trimethylsilyl and methylboronate derivatives. Methylboronate derivatives yielded strongly diminished chemical background and interference levels in the infrared chromatograms of standards and samples. The limit of identification for methylboronate derivatives was at the low ppb level in incurred samples. The similarity of analyte and reference spectra, together with the retention time, was found to be a useful criterion for confirmation of unknown compounds.
Visser
T
T
Laboratory for Organic Analytical Chemistry, National Institute of Public Health, Bilthoven, The Netherlands.
Vredenbregt
M J
MJ
de Jong
A P
AP
van Rossum
H J
HJ
Stephany
R W
RW
van Ginkel
L A
LA
D000318:Adrenergic beta-Agonists / Q000652:urine*; D000818:Animals; D001897:Boronic Acids; D002417:Cattle; D002849:Chromatography, Gas; D017550:Spectroscopy, Fourier Transform Infrared
D000318:Adrenergic beta-Agonists; D001897:Boronic Acids