title: Multiple disseminated meningioma. Case report.
abstract: A case of 32-year-old woman was described in which progressive bilateral hearing and visual loss, hypokinesia, epileptic focal seizures were present. The brain CT-scan after a few years of the disease onset, showed the presence of multiple extracerebral tumors. Multiple meningiomas were diagnosed, probably associated with von Recklinghausen's disease. On the post-mortem examination 48 tumors of the different size and location in subdural space were found. Histologically transitional meningiomas with predominance of fibroblastic component were diagnosed. It was very interesting that apart from intracranial location of meningiomas, the same type of tumor was found within thoracic spinal root. The authors discuss the mechanisms of the development of multiple meningiomas and its association with neurofibromatosis.
authors.affiliation: Department of Neurology, Medical School, Szczecin.
authors.forename: K
authors.initials: K
authors.lastname: Honczarenko
authors.forename: H
authors.initials: H
authors.lastname: Grzelec
authors.forename: P
authors.initials: P
authors.lastname: Nowacki
authors.forename: A
authors.initials: A
authors.lastname: Fabian
mesh_terms: D000328:Adult; D017668:Age of Onset; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D004388:Dura Mater / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008579:Meningioma / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D009378:Neoplasms, Multiple Primary; D014057:Tomography, X-Ray Computed