[Omeprazole and cimetidine in the treatment of upper digestive hemorrhage].
OBJECTIVE
To compare the efficacy of omeprazole (40 mgs/12 h i.v.) and cimetidine (1,200 mgs/i.v./day) in the management of upper gastrointestinal bleeding.


METHODS
Randomized, prospective open clinical trial. The end points are: mortality, surgical requirements, transfusion requirements, and length of hospitalization in Bleeding Unit and Hospital.


METHODS
We study patients with upper gastrointestinal bleeding from peptic sources (duodenal ulcer, gastriculcer, acute gastric erosions and peptic esophagitis). 462 patients are evaluated and 282 finally included.


RESULTS
151 patients were given cimetidine and 131 omeprazole. No significant differences in any of the end points were found.


CONCLUSIONS
The use of omeprazole does not improve cimetidine efficacy in the entire group of patients with upper gastrointestinal bleeding.
Uribarrena
R
R
Servicio de Aparato Digestivo, Hospital Miguel Servet, Zaragoza.
Bajador
E
E
Simón
M A
MA
Sebastián
J J
JJ
Gomollón
F
F
D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D011446:Prospective Studies
D002927:Cimetidine; D009853:Omeprazole
Omeprazol y cimetidina en el tratamiento de la hemorragia digestiva alta.