title: Technetium-99m HmPAO brain SPECT and outcome of hemispherectomy for intractable seizures.
abstract: With recent descriptions of the modified hemispherectomies and hemicorticectomy, there has been renewed interest in hemispherectomy for treatment of intractable seizures with hemiparesis. Because long-term outcome remains uncertain, patient selection remains difficult. 99mTc-HmPAO brain SPECT has been a helpful adjunct in the evaluation of epilepsy surgery candidates. We report SPECT scan findings in 7 patients who underwent hemispherectomy and compare these results with scalp EEG findings. Six patients had unilateral SPECT findings and all had a favorable outcome, regardless of surface EEG findings.
authors.affiliation: Department of Neurology, Children's Hospital; Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: L
authors.initials: L
authors.lastname: Carmant
authors.forename: L A
authors.initials: LA
authors.lastname: O'Tuama
authors.forename: P J
authors.initials: PJ
authors.lastname: Roach
authors.forename: U
authors.initials: U
authors.lastname: Kramer
authors.forename: M A
authors.initials: MA
authors.lastname: Mikati
authors.forename: J J
authors.initials: JJ
authors.lastname: Riviello
authors.forename: S L
authors.initials: SL
authors.lastname: Helmers
authors.forename: J R
authors.initials: JR
authors.lastname: Madsen
authors.forename: P M
authors.initials: PM
authors.lastname: Black
authors.forename: C T
authors.initials: CT
authors.lastname: Lombroso
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000098:blood supply; D002541:Cerebral Decortication; D002648:Child; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006429:Hemiplegia / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D008991:Monitoring, Physiologic; D015609:Organotechnetium Compounds; D010091:Oximes; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime