title: Aortic root replacement. Risk factor analysis of a seventeen-year experience with 270 patients.
abstract: Between September 1976 and September 1993, 270 patients underwent aortic root replacement at our institution. Two hundred fifty-two patients underwent a Bentall composite graft repair and 18 patients received a cryopreserved homograft aortic root. One hundred eighty-seven patients had a Marfan aneurysm of the ascending aorta (41 with dissection) and 53 patients had an aneurysm resulting from nonspecific medial degeneration (17 with dissection). These 240 patients were considered to have annuloaortic ectasia. Thirty patients were operated on for miscellaneous lesions of the aortic root. Thirty-day mortality for the overall series of 270 patients was 4.8% (13/270). There was no 30-day mortality among 182 patients undergoing elective root replacement for annuloaortic ectasia without dissection. Thirty-six of the 270 patients having root replacement also had mitral valve operations. There was no hospital mortality for aortic root replacement in these 36 patients, but there were seven late deaths. Twenty-two patients received a cryopreserved homograft aortic root; 18 of these were primary root replacements and four were repeat root replacements for late endocarditis. One early death and two late deaths occurred in this group. Actuarial survival for the overall group of 270 patients was 73% at 10 years. In a multivariate analysis, only poor New Year Heart Association class (III and IV), non-Marfan status, preoperative dissection, and male gender emerged as significant predictors of early or late death. Endocarditis was the most common late complication (14 of 256 hospital survivors) and was optimally treated by root replacement with a cryopreserved aortic homograft. Late problems with the part of the aorta not operated on occur with moderate frequency; careful follow-up of the distal aorta is critical to long-term survival.
authors.affiliation: Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Md 21287-4618.
authors.forename: V L
authors.initials: VL
authors.lastname: Gott
authors.forename: A M
authors.initials: AM
authors.lastname: Gillinov
authors.forename: R E
authors.initials: RE
authors.lastname: Pyeritz
authors.forename: D E
authors.initials: DE
authors.lastname: Cameron
authors.forename: B A
authors.initials: BA
authors.lastname: Reitz
authors.forename: P S
authors.initials: PS
authors.lastname: Greene
authors.forename: C D
authors.initials: CD
authors.lastname: Stone
authors.forename: R L
authors.initials: RL
authors.lastname: Ferris
authors.forename: D E
authors.initials: DE
authors.lastname: Alejo
authors.forename: V A
authors.initials: VA
authors.lastname: McKusick
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D001011:Aorta / Q000601:surgery*; D001018:Aortic Diseases / Q000401:mortality / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery / Q000637:transplantation; D006348:Cardiac Surgical Procedures / Q000401:mortality; D018572:Disease-Free Survival; D004696:Endocarditis / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D012307:Risk Factors; D016019:Survival Analysis; D013923:Thromboembolism / Q000453:epidemiology