Allopregnant IgG binds and modulates the activity of uterine beta adrenoceptors.
Female Balb/c mice were mated to C3H male mice, to obtain an allopregnant IgG. This allopregnant IgG con activate beta-adrenoceptors of C3H uterus. Here we show that allopregnant IgG interacts with beta-adrenoceptors in uterus of C3H mice and produces a decrease of the spontaneous motility and an increase of the intracellular cAMP concentration. Both effects are blocked by propranolol, a beta-adrenergic antagonist. Allopregnant IgG interferes with the binding of a specific beta adrenergic radioligand 3H-dihydroalprenolol behaving as a non competitive inhibitor. All these data indicate that allopregnant IgG could modulate the activity of uterine beta-adrenoceptors.
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CEFYBO-CONICET Serrano 669, Buenos Aires, Argentina.
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D000818:Animals; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D011247:Pregnancy; D011485:Protein Binding; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D014599:Uterus / Q000502:physiology*
D007074:Immunoglobulin G; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol