[The effect of the fluid medium on the completeness of skin restoration in rats].
Extent of the completeness of the tail skin restoration was studied in 30 outbred albino male rats after the induction of full-thickness defect 10 x 5 mm in size with the restoration process running under different conditions: without any effects (control group), with the constant perfusion, of the wounded surface with 0.9% sodium chloride solution up to the complete wound epithelialisation (experimental group 1), with the moisturing of the wounded surface by the gauze napkin, plentifully moisted with the 0.9% sodium chloride solution up to the complete epithelialisation (experimental group 2). Two months after the operation the defect control part was represented by the connective tissue scar in the control group and in the experimental group 2. Structures, resembling the terminal regions of the sebaceous glands, are developing from the newly formed epithelium in the experimental 1. The composition of the regenerate connective tissue closely resembles that of the intact derm. Thus, the constant perfusion of the wounded surface with the isotonic sodium chloride solution promotes the organotypic skin regeneration.
Ivanishchuk
P P
PP
Kovalev
A V
AV
D000818:Animals; D004848:Epithelium / Q000033:anatomy & histology / Q000187:drug effects / Q000293:injuries; D007552:Isotonic Solutions; D008297:Male; D051381:Rats; D012627:Sebaceous Glands / Q000033:anatomy & histology / Q000187:drug effects; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects* / Q000293:injuries; D012965:Sodium Chloride / Q000494:pharmacology*; D013623:Tail; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D007552:Isotonic Solutions; D012965:Sodium Chloride
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