[Clinical comparison of two topical antiviral ointments in herpes].
Herpetic skin lesions have importance and growing frequency in the population. The authors report a double blind study involving 51 patients suffering from recurrent labial herpes to compare the effectiveness and adverse reactions of two topical antiviral preparations, the aciclovir (Zovirax) and epervudine (Hevizos). There was no significant difference between the two treatment groups in the healing tendency of herpetic lesions. The rate of relapses in a two months period was 44.4% in the group treated with aciclovir and 20.8% in the group treated with epervudine, the difference is not significant. Both preparation was well tolerated, only itching occurred as adverse reaction in the group treated with aciclovir. According to the results of the study the original Hungarian product (Hevizos), is at least as effective as the other topical preparation.
Makleit
L
L
Biogal Gyógyszergyár Rt., Debrecen.
Nagy
M
M
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D003857:Deoxyuridine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006560:Herpes Labialis / Q000188:drug therapy / Q000382:microbiology; D006561:Herpes Simplex / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D018139:Simplexvirus / Q000187:drug effects / Q000302:isolation & purification
D000998:Antiviral Agents; D009824:Ointments; C048773:5-isopropyl-2'-deoxyuridine; D003857:Deoxyuridine; D000212:Acyclovir
Lokálisan ható két antiviralis kenöcs klinikai összehasonlítása herpesben.