Long-term fat intake and biomarkers.
The patterns of fatty acids maintained in human tissues reflect the dietary abundances of n-3 and n-6 fatty acids and the selectivities of the various lipid-metabolizing enzymes and transport systems in tissues. Similar selectivities for enzymes of mice, rats, and humans permit data from all three to be used in predicting average long-term tissue responses to different diets. The participation of the highly unsaturated fatty acids arachidonate (an n-6 acid) and eicosapentaenoate (an n-3 acid) in chronic pathophysiological events gives importance to predicting their tissue abundance. The average proportions in tissue phospholipids are hyperbolically related to dietary supplies of their precursors linoleate (18:2n-6) and linolenate (18:3n-3). In contrast, the precursors are maintained in tissue triacylglycerols in a linear relation to their average dietary supply.
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Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892-7003.
D000818:Animals; D015415:Biomarkers; D004041:Dietary Fats / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans
D015415:Biomarkers; D004041:Dietary Fats; D005227:Fatty Acids