Evidence of vitamin K deficiency in cord blood.
The prevalence of vitamin K deficiency in the newborns delivered at Siriraj Hospital was studied. The prolongation of one stage prothrombin time and the presence of PIVKA-II (non carboxylated prothrombin antigen) in cord blood were interpreted as the secondary change from vitamin K deficiency state. The most reliable method to diagnose vitamin K deficiency is the detection of vitamin K level in plasma which is not yet available in Thailand. Although the prevalence of vitamin K deficiency in the newborns from our data is not high, only 0.6%, it is shown that some of the apparently normal newborn infants may have bleeding problem from vitamin K deficiency in both newborn and early infancy periods. So, the correction of this deficiency by administration of vitamin K to all newborns is appropriate and reasonable decision.
Mahasandana
C
C
Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pung-amritt
P
P
Yodthong
S
S
Suvatte
V
V
D015415:Biomarkers; D001779:Blood Coagulation Factors / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D011498:Protein Precursors / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D011517:Prothrombin Time; D012680:Sensitivity and Specificity; D013785:Thailand; D014812:Vitamin K / Q000032:analysis* / Q000627:therapeutic use; D006475:Vitamin K Deficiency Bleeding / Q000097:blood* / Q000188:drug therapy / Q000276:immunology
D015415:Biomarkers; D001779:Blood Coagulation Factors; D011498:Protein Precursors; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin