Modulation of granuloma formation by endogenous nitric oxide.
We have studied the possible involvement of nitric oxide (NO) in granuloma formation induced by subcutaneous implantation in rats of carrageenin-soaked polyether sponges. Modulation of the L-arginine: NO pathway in rats was achieved by treating rats with the NO synthase inhibitor, NG-nitro-L-arginine methyl ester, as well as with L- or D-arginine. Granulomatous tissue formation, cell infiltration and NO2- production were reduced, in a dose-dependent manner, by NG-nitro-L-arginine methyl ester and increased by L-arginine but not by D-arginine. These results suggest that endogenous NO plays a modulating role in granuloma formation.
Iuvone
T
T
Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy.
Carnuccio
R
R
Di Rosa
M
M
D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology*; D007249:Inflammation / Q000188:drug therapy; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology*; D009573:Nitrites / Q000378:metabolism; D011108:Polymers; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
D004343:Drug Implants; D009573:Nitrites; D011108:Polymers; D009569:Nitric Oxide; D002351:Carrageenan; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester