title: Age-related changes of AMP breakdown in chicken heart.
abstract: The activity of adenylate deaminase, adenylate phosphatase and adenosine deaminase, as well as the endogenous content of adenine nucleotides, was examined in the heart of ageing chickens. In new-born (1-day-old) and young (20-day-old) chickens, AMP degradation in the heart seems to proceed preferentially through deamination, while in adult (1-year-old) through dephosphorylation. Compared with the adult heart, a 2-year-old one exhibits a decline of AMP catabolism. The total adenine nucleotide content and the concentration of ATP are higher in adult and aged chicken hearts, than in new-born and young ones. Adaptive mechanisms might occur in the heart of ageing chickens to ensure an adequate availability of adenine nucleotides.
authors.affiliation: Institute of Histology and Embryology, University of Bologna, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Wegelin
authors.forename: G
authors.initials: G
authors.lastname: Pane
authors.forename: C
authors.initials: C
authors.lastname: Finelli
authors.forename: C
authors.initials: C
authors.lastname: Clô
authors.forename: M L
authors.initials: ML
authors.lastname: Zanfanti
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002645:Chickens / Q000378:metabolism*; D015636:Magnesium Chloride / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*
chemical_list: D015636:Magnesium Chloride; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase