title: Multiple cranial neuritis associated with large granular lymphocytosis.
abstract: A patient with a unique form of large granular lymphocytosis and multiple cranial neuritis is reported. The patient presented with facial weakness, diplopia and dysarthria. An increase in large granular lymphocytes (LGLs) was seen in blood (1.8 x 10(9)/l), CSF (237/microliters) and bone marrow (20% in a normocellular bone marrow). The phenotype of the LGLs in CSF, blood and bone marrow was CD2+ CD3+ CD4+ CD8- CD16- CD56- and CD57-. The unique features of this case include the CD4+ phenotype, the relative abundance of CSF LGL and the clinical presentation.
authors.affiliation: Department of Neurology and Gerontology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kono
authors.forename: T
authors.initials: T
authors.lastname: Takashima
authors.forename: S
authors.initials: S
authors.lastname: Tsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Ijichi
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Araki
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D003389:Cranial Nerve Diseases / Q000175:diagnosis; D005155:Facial Nerve Diseases / Q000175:diagnosis*; D017809:Fatal Outcome; D005930:Glossopharyngeal Nerve; D006801:Humans; D016130:Immunophenotyping; D008218:Lymphocytosis / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009443:Neuritis / Q000175:diagnosis*; D014321:Trochlear Nerve; D014630:Vagus Nerve
chemical_list: D015703:Antigens, CD