Ameloblastoma with stromal multinucleated giant cells.
We report a case of ameloblastoma which uniquely showed heavy osteoclast-like giant cell accumulation and woven bone formation in the surrounding fibrous stroma. Immunohistochemistry showed that the giant cells were non-epithelial in origin and suggested that stromal factors (i.e., the presence or absence of mineralized bone) determines whether these cells express an osteoclastic antigenic phenotype.
Richard
B M
BM
International Nepal Fellowship, Pokhara.
Thyveetil
M
M
Sharif
H
H
Athanasou
N A
NA
D000328:Adult; D000564:Ameloblastoma / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D008441:Maxillary Neoplasms / Q000473:pathology*