Effect of famotidine on ciprofloxacin pharmacokinetics after single intravenous and oral doses in rats.
The effect of intravenous (3.5 mg/kg) and oral (5 mg/kg) famotidine on ciprofloxacin pharmacokinetics after single (i.v.) intravenous (5 mg/kg) and oral (20 mg/kg) doses were examined in the rat. Famotidine co-administration significantly increased the terminal elimination half-life of ciprofloxacin (54% and 29% following i.v. and oral administration, respectively) and tended to reduce the total body clearance by 27% and 34% following i.v. and oral routes, respectively. The area under the plasma concentration-time curve and the mean residence time in the body after i.v. and oral doses were significantly increased following famotidine co-administration. No changes in the steady-state apparent volume of distribution was observed after i.v. administration. The maximum plasma concentration and the time to peak concentration after oral dosing were also unaffected. These results suggest a possible reduction in the total clearance of ciprofloxacin, owing to inhibition of its renal tubular excretion by famotidine. Further studies are warranted to determine whether this interaction occurs in humans.
al-Khamis
K I
KI
College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Jim
L K
LK
Bawazir
S A
SA
Ashour
L F
LF
el-Sayed
N
N
el-Sayed
Y M
YM
D000284:Administration, Oral; D000818:Animals; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D015738:Famotidine / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats
D002939:Ciprofloxacin; D015738:Famotidine