title: Organization of the human serotonin transporter gene.
abstract: The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.
authors.affiliation: Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
authors.forename: K P
authors.initials: KP
authors.lastname: Lesch
authors.forename: U
authors.initials: U
authors.lastname: Balling
authors.forename: J
authors.initials: J
authors.lastname: Gross
authors.forename: K
authors.initials: K
authors.lastname: Strauss
authors.forename: B L
authors.initials: BL
authors.lastname: Wolozin
authors.forename: D L
authors.initials: DL
authors.lastname: Murphy
authors.forename: P
authors.initials: P
authors.lastname: Riederer
mesh_terms: D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons; D005796:Genes; D006801:Humans; D007438:Introns; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D001523:Mental Disorders / Q000235:genetics; D018598:Minisatellite Repeats; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D002352:Carrier Proteins; D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin