[The significance of HLA DR6 and DR8 among patients with rheumatoid arthritis].
Among 380 patients with rheumatoid arthritis (RA), there were 63 cases who had HLA DR4 without any other counterpart DR type (Group DR4.*), 30 with DR6 but without DR4 (Group DR6.DR4-), 37 with both DR6 and DR4 (Group DR6.DR4+), 34 with DR8 but without DR4 (Group DR8.DR4-), and 15 with both DR8 and DR4 (Group DR8.DR4+). 53, 29, 32, 32, or 13 female RA patients respectively from Groups DR4.*, DR6.DR4-, DR6.DR4+, DR8.DR4-, or DR8.DR4+ were investigated for the severity of their disease. 40 joints in 18 patients, 2 in 1, 19 in 8, 13 in 6, or 10 in 4 respectively from Groups DR4.*, DR6.DR4-, DR6.DR4+, DR8.DR4-, or DR8.DR4+ had had the previous history of total joint replacement operations for the diseased hips (THR) or knees (TKR). The number of cases (p < 0.01) or that of joints (p < 0.001) was significantly less among Group DR6.DR4- patients than the corresponding figure among Group DR4.* patients. Significantly smaller (p < 0.02) number of cases with DR6 (Groups DR6.DR4- and DR6.DR4+ combined) had experienced THR's and/or TKR's than those in Group DR4.*. Group DR8.DR4- patients had undergone THR/TKR operations in smaller number of the joints (p < 0.05) in comparison to Group DR4.* patients, though the difference was not significant when the numbers of operated cases were compared between the Groups. The age at RA onset among Groups DR4.*, DR6.DR4-, DR6.DR4+, DR8.DR4-, or DR8.DR4+ was 38.5 +/- 14.2 (mean +/- SD) years, 46.6 +/- 12.2, 41.7 +/- 11.7, 44.9 +/- 13.1, or 40.8 +/- 10.2 respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Matsuura
M
M
Department for Rheumatic Diseases, Tokyo Metropolitan Fuchu General Hospital.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood*; D059810:HLA-DR Serological Subtypes; D015804:HLA-DR4 Antigen / Q000097:blood; D015808:HLA-DR6 Antigen / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015804:HLA-DR4 Antigen; D015808:HLA-DR6 Antigen; C041559:HLA-DR8 antigen