Facilitation of hippocampal potentials by suramin.
The influence of suramin, a suggested purino-receptor antagonist, on the evoked synaptic potentials recorded from hippocampal slices was evaluated. The suramin induced a nondecremental, concentration-dependent amplification of the slope of excitatory postsynaptic potential and magnitude of the population spike (long-term potentiation, LTP). The effect of suramin was completely abolished by adenylimidodiphosphate, a non-hydrolyzable analogue of ATP, and markedly reduced by NMDA-receptor antagonists DL-2-amino-5-phosphonovaleric acid and MK-801. These results indicate that, in addition to acting as an antagonist of P2 receptors, suramin is also able to facilitate hippocampal potentials in a way that involves mechanisms participating in induction of LTP.
Wieraszko
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CSI/IBR Center for Developmental Neuroscience and Developmental Disabilities, College of Staten Island, City University of New York 10314.
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000266:Adenylyl Imidodiphosphate / Q000494:pharmacology; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D013498:Suramin / Q000494:pharmacology*
D000266:Adenylyl Imidodiphosphate; D013498:Suramin; D016291:Dizocilpine Maleate; D015763:2-Amino-5-phosphonovalerate