title: Proton magnetic resonance spectroscopy in patients with ischemic stroke.
abstract: Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive technique which has proved to be useful for monitoring various brain metabolites (N-acetyl-aspartate, choline, creatine-phosphocreatine, lactate). A total of 18 patients underwent a combined magnetic resonance imaging (MRI)/1H-MRS protocol in order to evaluate the distribution of the metabolites in the various stages of cerebral ischemia. Our results show a marked decrease of N-acetyl-aspartate and a large content of Lactate during the early phases, and a decrease in N-acetyl-aspartate, choline and creatine-phosphocreatine (Cr-PCr) during the chronic phase.
authors.affiliation: Istituto di Clinica Neurologica, Università di Bari.
authors.forename: F
authors.initials: F
authors.lastname: Federico
authors.forename: C
authors.initials: C
authors.lastname: Conte
authors.forename: I L
authors.initials: IL
authors.lastname: Simone
authors.forename: P
authors.initials: P
authors.lastname: Giannini
authors.forename: M
authors.initials: M
authors.lastname: Liguori
authors.forename: E
authors.initials: E
authors.lastname: Picciola
authors.forename: C
authors.initials: C
authors.lastname: Tortorella
authors.forename: E
authors.initials: E
authors.lastname: Ferrari
mesh_terms: D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000175:diagnosis / Q000378:metabolism*; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000378:metabolism
chemical_list: D007773:Lactates; D010725:Phosphocreatine; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline