Cdk inhibitors: on the threshold of checkpoints and development.
The regulation of cyclin-dependent kinases is at the heart of cell cycle control and, by inference, the control of cell proliferation. Recent advances in regulation of these kinases have uncovered a group of small proteins that bind to and inhibit them, thus preventing cell cycle progression. Linking these proteins to tumor suppressor functions has provided a much sought after connection between cancer and cell cycle control.
Elledge
S J
SJ
Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030.
Harper
J W
JW
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D006801:Humans; D008322:Mammals; D009369:Neoplasms / Q000201:enzymology; D012441:Saccharomyces cerevisiae
D018844:Cyclin-Dependent Kinases