[Risk analysis of combination effects of risk factors for primary liver cancer].
Combination effects of major risk factors for primary liver cancer (PLC) was evaluated by generalized relative risk model to examine the adequacy of the multiplicative structure for describing the effects of them and to estimate their relative risk (RR) and population attributable risk (PAR). The results suggested combination effects of hepatitis B virus (HBV) infection and drinking pond-ditch water tended to be multiplicative, and that of aflatoxin B1 (AFB1) contamination and HBV infection and drinking pond-ditch water to be additive. The relative importance of these factors of PLC based on their RR and PAR was HBV infection, drinking pond-ditch water, and AFB1 contamination in proper order. Recognition of the mode of the combination effects of relevant risk factors was important for the causal explanation and public health practice.
Zhao
N
N
Department of Epidemiology Shanghai Medical University.
Yu
S Z
SZ
D016604:Aflatoxin B1 / Q000009:adverse effects; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology*; D015233:Models, Statistical; D012307:Risk Factors; D014876:Water Pollution
D016604:Aflatoxin B1