title: Epidermal growth factor excretion in burned rats.
abstract: Evidence for epidermal growth factor (EGF) involvement in the physiological response to burns was sought from urinary levels of EGF, urea and creatinine in male rats using a standardized thermal skin injury model (25 per cent body surface) and treated with fluid resuscitation. Postmortem, the skin lesions were studied by microscopy to guarantee the absence of inflammatory complications. Statistically significant differences were observed in body weight, urea and creatinine excretion when compared to the basal values. When EGF excretion results were evaluated as raw data (expressed as ng/mg of creatinine or ng/day) compared to basal levels, no statistically significant differences were observed. However, when the results were expressed as percentage increases with respect to the basal values, a statistically significant increase was found over the first 7 days postinjury (P = 0.029).
authors.affiliation: Metabolic Research Unit Santiago Grisolia, Department of Biochemistry, Hospital General Vall d'Hebron, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Farriol
authors.forename: S
authors.initials: S
authors.lastname: Schwartz
authors.forename: J
authors.initials: J
authors.lastname: Rossello
authors.forename: R
authors.initials: R
authors.lastname: Galard
authors.forename: R
authors.initials: R
authors.lastname: Catalan
authors.forename: P
authors.initials: P
authors.lastname: Huguet
mesh_terms: D000818:Animals; D002056:Burns / Q000503:physiopathology / Q000652:urine*; D003404:Creatinine / Q000652:urine; D004815:Epidermal Growth Factor / Q000502:physiology / Q000652:urine*; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004815:Epidermal Growth Factor; D003404:Creatinine