[Microcalorimetric study of the effect of mitoxantrone on chromatin DNA in vivo].
The influence of antitumor drugs--mitocsantron on the chromatine of tumor cells spleen tissue of BALB/c-mice has been established. Two-stage denaturation process of chromatine in normal cells has been shown. The first stage--thermolabel domain can be described by the following transition parameters: Td1 = 72, delta Td1 = 6.2 degrees C, Qd1 = 36.5 J/g DNA; the second one-thermostable domain by Td2 = 83, delta Td2 = 9.0 degrees C kappa Qd2 = 58 J/g DNA.
Monaselidze
D R
DR
Kalandadze
Ia L
IaL
Khachidze
D G
DG
Topuridze
I
I
D000818:Animals; D002152:Calorimetry, Differential Scanning; D002478:Cells, Cultured; D002843:Chromatin / Q000737:chemistry / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008942:Mitoxantrone / Q000494:pharmacology*; D011489:Protein Denaturation; D013154:Spleen / Q000737:chemistry / Q000187:drug effects; D013816:Thermodynamics; D014407:Tumor Cells, Cultured
D002843:Chromatin; D004273:DNA, Neoplasm; D008942:Mitoxantrone
Mikrokalorimetricheskoe issledovanie vliianiia mitoksantrona na DNK khromatina in vivo.