title: Depression of cytochrome P-450 in mouse liver induced by fractions from Nocardia opaca.
abstract: We measured the liver cytochrome P-450 content of mice 24 h after they had been injected with the following immunoadjuvants: Nocardia opaca derivatives and peptidoglycans from several bacterial strains. The cell wall fraction was not active, the others diminished liver cytochrome P-450 levels. The dose-response activity varied with the bacterial origin of the peptidoglycans. These findings indicate that the toxicity and efficiency of immunochemotherapeutic protocols can be modified by altering drug metabolism.
authors.affiliation: Laboratory for Special Medical Microbiology and Immunology, Faculty of Medicine, Charles University, Prague, Czeck Republic.
authors.forename: J
authors.initials: J
authors.lastname: Ocenásková
authors.forename: M
authors.initials: M
authors.lastname: Mara
authors.forename: S
authors.initials: S
authors.lastname: Orbach-Arbouys
authors.forename: M
authors.initials: M
authors.lastname: Leclerc
authors.forename: R
authors.initials: R
authors.lastname: Barot-Ciorbaru
mesh_terms: D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology*; D009615:Nocardia / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System