Evaluation of the Omniflow collagen-polymer vascular prosthesis.
The Omniflow Vascular Prosthesis (OVP) is a truly integrated bio-synthetic composite of polyester mesh and ovine connective tissue components. In animal and human studies, the prosthesis has demonstrated long-term patency rates comparable and often better than alternate surgical replacements, with minimal aneurysmal or thrombotic problems. Immunohistological and TEM analysis of explants of OVP I provide good evidence for the excellent in vivo performance and are reviewed below. In addition, new data from explants of the OVP II, a later version of the Omniflow, are also described. These explant analyses have been enhanced by use of a library of highly specific monoclonal antibodies which can discriminate between collagens from different species.
Werkmeister
J A
JA
CSIRO, Division of Biomolecular Engineering, Parkville, Victoria, Australia.
White
J F
JF
Ramshaw
J A
JA
D000818:Animals; D000911:Antibodies, Monoclonal; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D003094:Collagen; D006801:Humans; D008422:Materials Testing; D011091:Polyesters; D011474:Prosthesis Design; D014654:Vascular Patency
D000911:Antibodies, Monoclonal; D011091:Polyesters; D003094:Collagen