Translational control of cytokine expression by 3' UA-rich sequences.
Several messenger RNAs which are transiently expressed contain a conserved uridine-adenosine-rich sequence in their 3' untranslated region. Many of these mRNas encode cytokines, growth factors or oncoproteins. This UA-rich sequence is composed of several interpsersed repeats of the octanucleotide UUAUUUAU and plays a key role in the post-transcriptional regulation of these mRNAs. Known as instability determinants, these UA-rich elements can also strongly affect mRNA translational efficiency. In this report, we review the data which illustrate this translational regulation and give insight the underlying mechanism.
Kruys
V
V
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode-Saint-Genèse, Belgium.
Huez
G
G
D000241:Adenosine / Q000235:genetics; D000818:Animals; D001483:Base Sequence / Q000235:genetics* / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis* / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D014176:Protein Biosynthesis; D012045:Regulatory Sequences, Nucleic Acid; D012091:Repetitive Sequences, Nucleic Acid; D014529:Uridine / Q000235:genetics
D016207:Cytokines; D000241:Adenosine; D014529:Uridine