Antihypertensive effect of the clerodane diterpene ajugarin I on experimentally hypertensive rats.
Anti-hypertensive studies on ajugarin I, a representative example of a range of biologically active clerodane diterpenes was carried out. Administration of ajugarin I at 10 mg/1 in the drinking water of experimentally hypertensive rats, lowered their blood pressure from 165.00 +/- 1.57 mmHg to a normotensive level of about 116.33 +/- 1.67 mmHg in two weeks. These observations could open up new research avenues in the development of a new drug for the treatment of hypertension in humans.
Odek-Ogunde
M
M
Department of Zoology, Moi University, Eldoret, Kenya.
Rajab
M S
MS
D000818:Animals; D004195:Disease Models, Animal; D004224:Diterpenes / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D007630:Kenya; D008297:Male; D016488:Medicine, African Traditional; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride
D004224:Diterpenes; D010936:Plant Extracts; D012965:Sodium Chloride; C092328:ajugarin I