Effects of carbaryl on some dopaminergic behaviors in rats.
1. The effects of acute oral administration of carbaryl (10-80 mg/kg), a carbamate insecticide, on some experimental models for detecting dopaminergic activity were examined in rats. Also, serum biochemical variables following carbaryl treatments were determined. 2. Carbaryl (20 and 40 mg/kg) significantly increased the number of apomorphine-induced yawns and at dose of 80 mg/kg it prolonged the duration time of haloperidol-induced catalepsy. Pretreatment with carbaryl failed to affect apomorphine-induced stereotypes. 3. Carbaryl significantly reduced blood cholinesterase activity and elevated blood glucose levels and SGOT and SGPT activities. 4. These results indicate that low oral doses of carbaryl can cause behavioral and toxicological effects in rats.
Rigon
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AR
Departamento de Farmacologia, Universidade Federal Santa Catarina, Florianópolis, Brasil.
Reis
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M
Takahashi
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RN
D000284:Administration, Oral; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D012721:Carbaryl / Q000008:administration & dosage / Q000633:toxicity*; D002375:Catalepsy; D002802:Cholinesterases / Q000097:blood; D004298:Dopamine / Q000502:physiology; D006220:Haloperidol; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*; D015000:Yawning / Q000187:drug effects*
D002802:Cholinesterases; D006220:Haloperidol; D001058:Apomorphine; D012721:Carbaryl; D004298:Dopamine