Long-term remission of neutropenia in Felty's syndrome after a short GM-CSF treatment.
We report a case of Felty's syndrome in which neutropenia was corrected by a short-term treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, 5 micrograms/kg/day s.c. for 14 days). Absolute neutrophil counts rose from 0.1 to 2.2 x 10(9)/l and remained > 1.0 x 10(9)/l 8 weeks after discontinuation of the GM-CSF therapy. A flare-up of arthritis and a decrease in platelet counts were observed.
Pereira
J
J
Fundação Pró-Sangue/Hemocentro de São Paulo, Brazil.
Velloso
E D
ED
Loterio
H A
HA
Laurindo
I M
IM
Chamone
D A
DA
D000328:Adult; D004804:Eosinophils / Q000187:drug effects; D005258:Felty Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D009503:Neutropenia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D009504:Neutrophils / Q000187:drug effects; D011994:Recombinant Proteins / Q000008:administration & dosage; D012074:Remission Induction; D013997:Time Factors
D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor