Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior.
OBJECTIVE
Previous studies have demonstrated a relationship between obsessive-compulsive disorder or behavior and Gilles de la Tourette syndrome. It has been hypothesized that the serotonergic system is implicated in the etiology of obsessive-compulsive disorder. Therefore, the authors investigated whether genetic variation in a serotonergic receptor and a modifying enzyme were associated with Tourette's syndrome.


METHODS
A linkage analysis using DNA and blood group markers was carried out in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior.


RESULTS
There was no evidence to support the hypothesis that genetic variation in the serotonin 5-HT1A receptor and tryptophan oxygenase genes causes susceptibility to Tourette's syndrome and chronic multiple tics.


CONCLUSIONS
The results eliminate two possible candidate genes from having a role in the pathophysiology of Tourette's syndrome.
Brett
P M
PM
Academic Psychiatry Department, University College London Medical School, England.
Curtis
D
D
Robertson
M M
MM
Gurling
H M
HM
D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008126:Lod Score; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree; D011985:Receptors, Serotonin / Q000235:genetics* / Q000502:physiology; D012701:Serotonin / Q000235:genetics / Q000502:physiology; D013981:Tic Disorders / Q000235:genetics; D005879:Tourette Syndrome / Q000235:genetics* / Q000503:physiopathology; D014366:Tryptophan Oxygenase / Q000235:genetics* / Q000502:physiology
D005819:Genetic Markers; D011985:Receptors, Serotonin; D012701:Serotonin; D014366:Tryptophan Oxygenase