Anti-inflammatory and antipyretic effects of boldine.
Boldine, an antioxidant alkaloid isolated from Peumus boldus, exhibits a dose-dependent anti-inflammatory activity in the carrageenan-induced guinea pig paw edema test with an oral ED50 of 34 mg/kg. Boldine also reduces bacterial pyrogen-induced hyperthermia in rabbits to an extent which varied between 51% and 98% at a dose of 60 mg/kg p.o. In vitro studies carried out in rat aortal rings revealed that boldine is an effective inhibitor of prostaglandin biosynthesis, promoting 53% inhibition at 75 microM. The latter in vitro effect may be mechanistically linked to the anti-inflammatory and antipyretic effects of boldine exerted in vivo.
Backhouse
N
N
Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
Delporte
C
C
Givernau
M
M
Cassels
B K
BK
Valenzuela
A
A
Speisky
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001060:Aporphines / Q000494:pharmacology*; D002351:Carrageenan; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000473:pathology; D006168:Guinea Pigs; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001060:Aporphines; D008070:Lipopolysaccharides; C011686:boldine; D002351:Carrageenan; D011464:Epoprostenol