Drug delivery systems based on inorganic materials: I. Synthesis and characterization of a zeolite-cyclophosphamide system.
Porous material of the CuX zeolite type has been synthesized and used as support for a classic antitumoral drug--cyclophosphamide (CP). The new material obtained represents a physical mixture of the two components. In vivo tests allowed biochemical and anatomopathological evaluation of antitumoral effects determined by oral administration of the CuX zeolite-CP system. Data obtained show that the intensity of the antitumoral effects of the CuX zeolite-CP system is similar as compared to that achieved by CP. A possible advantage of the CuX zeolite-CP system is the continual maintenance in the blood of a CP concentration ranging between 100 and 1,000 ng ml-1 plasma.
Uglea
C V
CV
Institute of Biological Research, Iassy, Romania.
Albu
I
I
Vătăjanu
A
A
Croitoru
M
M
Antoniu
S
S
Panaitescu
L
L
Ottenbrite
R M
RM
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D008297:Male; D008422:Materials Testing; D051381:Rats; D017208:Rats, Wistar; D017641:Zeolites / Q000737:chemistry*
D000970:Antineoplastic Agents; D017641:Zeolites; D003520:Cyclophosphamide