Epithelial antibiotics induced at sites of inflammation.
The role of antimicrobial peptides in epithelial defense is not fully understood. An epithelial beta-defensin, lingual antimicrobial peptide (LAP), was isolated from bovine tongue and the corresponding complementary DNA cloned. LAP showed a broad spectrum of antibacterial and antifungal activities. LAP messenger RNA abundance was markedly increased in the epithelium surrounding naturally occurring tongue lesions. This increase coincided with the cellular hallmarks of acute and chronic inflammation in the underlying lamina propria, supporting a role for epithelial antimicrobial peptides as integral components of the inflammatory response.
Schonwetter
B S
BS
Magainin Research Institute, Magainin Pharmaceuticals, Inc., Plymouth Meeting, PA 19462.
Stolzenberg
E D
ED
Zasloff
M A
MA
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001483:Base Sequence; D002175:Candida / Q000187:drug effects; D002417:Cattle; D004848:Epithelium / Q000737:chemistry / Q000378:metabolism; D005928:Glossitis / Q000378:metabolism*; D017403:In Situ Hybridization; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D014059:Tongue / Q000737:chemistry / Q000196:embryology / Q000378:metabolism*; D023083:beta-Defensins
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011506:Proteins; D012333:RNA, Messenger; D023083:beta-Defensins; C092480:lingual antimicrobial peptide