Bombesin-induced anorexia requires central bombesin receptor activation: independence from interaction with central catecholaminergic systems.
Intraperitoneal (IP) administration of bombesin (BBS; 2.5-20 micrograms/kg) induced a dose-dependent inhibition of food intake. The effect was decreased by intraventricular (ICV) administration of bombesin receptor antagonist [Leu14-psi (CH2NH)-Leu13] (3 micrograms/rat) but not by the D1 antagonist SCH 23390, the D2 antagonists sulpiride and pimozide, the dopamine antagonist cis-flupentixol, adrenoceptor blockers phenoxybenzamine or propranolol and serotonergic antagonist methergoline. It is concluded that BBS-induced suppression of feeding may be mediated through central BBS receptors, and is independent of interaction with brain catecholaminergic system.
Motamedi
F
F
Department of Physiology, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rashidy-Pour
A
A
Zarrindast
M R
MR
Badavi
M
M
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D000855:Anorexia / Q000139:chemically induced* / Q000523:psychology; D001839:Bombesin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002395:Catecholamines / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D018004:Receptors, Bombesin / Q000037:antagonists & inhibitors / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D018492:Dopamine Antagonists; D018004:Receptors, Bombesin; D012702:Serotonin Antagonists; D001839:Bombesin