title: Experimental myopia in chickens induced by corneal astigmatism.
abstract: Astigmatism has been suggested to be an important factor in the production and/or progression of myopia. Chickens have been used as a myopic animal model for several years. In the present investigation our aim was to evaluate the importance of surgically induced corneal astigmatism by peripheral corneal incision with compression suture in one eye, the right, of 3-day-old chicks. Vertical incision (2 mm) with compression suture (nylon 9-0, one stitch) induces against-the-rule astigmatism, horizontal incision with compression induces with-the-rule astigmatism. Four groups were studied 1) with one vertical cut, 2) one horizontal cut, 3) two vertical cuts, 4) two horizontal cuts. The eyes were measured by caliper after 8 weeks. Eye enlargements were induced in all groups, however, less by one cut (astigmatism around 5 diopters) than by two cuts (astigmatism 10 diopters, or more). In the latter groups the pattern of equatorial eye enlargement depended on the axis of the induced astigmatism, the greater elongation being associated with the strongest refracting corneal meridian. All considered, the results suggest that significant corneal astigmatism could be another factor in the production of myopia, possibly acting by way of optical degradation of retinal image quality.
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei.
authors.forename: Y F
authors.initials: YF
authors.lastname: Shih
authors.forename: T C
authors.initials: TC
authors.lastname: Ho
authors.forename: M S
authors.initials: MS
authors.lastname: Chen
authors.forename: L L
authors.initials: LL
authors.lastname: Lin
authors.forename: P C
authors.initials: PC
authors.lastname: Wang
authors.forename: P K
authors.initials: PK
authors.lastname: Hou
mesh_terms: D000818:Animals; D001251:Astigmatism / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D002645:Chickens; D003315:Cornea / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D005123:Eye / Q000473:pathology; D006984:Hypertrophy; D009216:Myopia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013536:Suture Techniques