Relative effects on serum lipids and apolipoproteins of a caprenin-rich diet compared with diets rich in palm oil/palm-kernel oil or butter.
Two randomized, blind studies measured changes in serum cholesterol, other serum lipids, and apolipoprotein (apo) concentrations in hypercholesterolemic men consuming caprenin (Cap)-rich diets after either baseline diets enriched in palm oil/palm-kernel oil (PO/PKO) or butter. The triglyceride Cap contains 45% 22:0 and 50% 8:0-10:0. Compared with baseline values established at 3 wk on the PO/PKO diet, the 17 subjects on the Cap diet showed significant reductions after 6 wk in HDL cholesterol (HDL-C), HDL2-C, and HDL3-C and a significant increase in the ratio of total cholesterol, LDL-C, triglycerides, apo B-100, or apo A-I were seen. Compared with baseline values established at 3 wk on the butter diet, after 6 wk the seven subjects receiving the Cap diet showed no significant changes in the lipid and apolipoprotein indexes analyzed. These data show that one or more of 8:0, 10:0, and 22:0 fatty acids can contribute to hypercholesterolemia in men.
Wardlaw
G M
GM
Division of Medical Dietetics, Ohio State University, Columbus 43210.
Snook
J T
JT
Park
S
S
Patel
P K
PK
Pendley
F C
FC
Lee
M S
MS
Jandacek
R J
RJ
D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D015992:Body Mass Index; D002079:Butter; D002210:Caprylates / Q000008:administration & dosage / Q000494:pharmacology*; D003652:Decanoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism; D005227:Fatty Acids / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008297:Male; D000073878:Palm Oil; D010938:Plant Oils / Q000494:pharmacology*; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology*
D001053:Apolipoproteins; D002210:Caprylates; D003652:Decanoic Acids; D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids; D010938:Plant Oils; D014280:Triglycerides; C085281:caprenin; D000073878:Palm Oil; D002079:Butter