Effect of sulglycotide in the prevention of duodenal ulcer relapse.
OBJECTIVE
To evaluate the effectiveness of sulglycotide, a gastroprotective drug, as maintenance treatment for patients with duodenal ulcer.


METHODS
A randomized double-blind study.


METHODS
A total of 119 patients with recently healed duodenal ulcers were randomly allocated, in a double-blind fashion, to receive sulglycotide 200 mg twice daily (60 patients) or placebo (59 patients) for 1 year. Patients underwent clinical assessment every third month and endoscopy at 6 and 12 months, or earlier if relapse was suspected.


RESULTS
The cumulative endoscopic relapse rates, compared using the log rank test, were 37 and 52% after 6 and 12 months, respectively, in the sulglycotide group and 62 and 71% (P = 0.03), respectively, in the placebo group.


CONCLUSIONS
Sulglycotide is moderately effective as a maintenance treatment for duodenal ulcer disease.
De Conca
V
V
Division of Gastroenterology, Galliera Hospital, Genova, Italy.
Saccomanno
S
S
Dodero
M
M
Aste
H
H
D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012795:Sialoglycoproteins / Q000009:adverse effects / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D012795:Sialoglycoproteins; C009354:sulglicotide