Effect of alloxan-induced diabetes on Na+, K(+)-ATPase activity from discrete areas of the rat brain.
The effect of alloxan-induced diabetes was studied on the activity of Na+, K(+)-ATPase enzyme which is involved in numerous reactions in the metabolism of the synaptic region, Na+, K(+)-ATPase activity was examined in brain areas such as septum, amygdala, thalamus, hippocampus, pons and medulla, and in hypothalamic areas such as medial preoptic and median eminence-arcuate region. In all these areas studied, diabetes caused a decrease in the activity of Na+, K(+)-ATPase, whereas, insulin administration reversed this effect. The present results may indicate the possible involvement of Na+, K(+)-ATPase in neuropathophysiology of diabetes.
Kaur
G
G
Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.
Lakhman
S S
SS
D000679:Amygdala / Q000201:enzymology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005260:Female; D006624:Hippocampus / Q000201:enzymology; D007031:Hypothalamus / Q000201:enzymology; D007328:Insulin / Q000494:pharmacology; D008526:Medulla Oblongata / Q000201:enzymology; D011149:Pons / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D012688:Septum Pellucidum / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013788:Thalamus / Q000201:enzymology
D007328:Insulin; D000254:Sodium-Potassium-Exchanging ATPase