Contact photosensitivity to nonoxynol used in antiseptic preparations.
Nonoxynols are nonionic surface-active agents used as surfactant in numerous cosmetic products and antiseptic preparations. Recently nonoxynol contact allergy has been described. We report two patients who presented a contact photosensitivity to nonoxynol 10 contained in Hexomédine transcutanée. Among 32 control subjects, we found 13 positive photopatch tests to Hexomédine transcutanée and 4 positive photopatch tests to nonoxynol 10. Surprisingly, the authors observed that only undiluted nonoxynol was phototoxic.
Michel
M
M
Service de Dermatologie, Centre Hospitalier Universitaire, Caen, France.
Dompmartin
A
A
Moreau
A
A
Leroy
D
D
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000032:analysis; D001550:Benzamidines / Q000008:administration & dosage* / Q000032:analysis; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000175:diagnosis; D008297:Male; D017137:Nonoxynol / Q000009:adverse effects* / Q000032:analysis; D015434:Panniculitis / Q000188:drug therapy; D010328:Patch Tests; D014677:Pharmaceutical Vehicles / Q000009:adverse effects / Q000032:analysis; D010787:Photosensitivity Disorders / Q000209:etiology*
D000891:Anti-Infective Agents, Local; D001550:Benzamidines; D014677:Pharmaceutical Vehicles; D017137:Nonoxynol; C018961:hexamidine