Phospholipids metabolism in platelets stimulated with collagen.
Collagen addition to platelets suspended in Calcium-free medium induces slow shape change followed by fast aggregates formation. Time courses of membrane phospholipids metabolism and arachidonic acid oxidative metabolism indicate that phospholipase C is the immediate target of the stimulus, and subsequently phospholipase A-2 is activated by synergistic action of released calcium and protein kinase C.
Ferri
A
A
Department of Biochemistry and Molecular Biology, University of Ferrara, Italy.
Calza
R
R
D016718:Arachidonic Acid / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction; D010713:Phosphatidylcholines / Q000097:blood; D010714:Phosphatidylethanolamines / Q000097:blood; D010716:Phosphatidylinositols / Q000097:blood; D010741:Phospholipases A / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D010738:Type C Phospholipases / Q000097:blood
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D010743:Phospholipids; D017392:Thiobarbituric Acid Reactive Substances; D016718:Arachidonic Acid; D008315:Malondialdehyde; D003094:Collagen; D010741:Phospholipases A; D010738:Type C Phospholipases; D002118:Calcium