title: [Detection of DNA of human papillomaviruses (HPV) in an "aggressively" growing cholesteatoma. Is cholesteatoma a virus-induced tumor?].
abstract: It is yet unknown why under certain circumstances the benign epithelium covering the outer ear canal in a protective role causes an erosion of bony structures after migration into the middle ear. Histologically, a papillomatous growth and clusters of koilocytes are typical features of the aggressively growing, bone-destructive areas of the cholesteatoma. Since these resemble the characteristics of a papilloma, biopsies originating from cholesteatomas were examined for the presence of human papillomavirus (HPV) DNA. Findings demonstrated that HPV-11-related DNA was present in one such lesion. In general, papilloma viruses need specific conditions to be able to replicate and induce a papillomatous growth. Retraction pockets of epithelium, junction lines between squamous epithelium and mucosa as well as inflammatory processes may stimulate this replication. Because these conditions are characteristic for cholesteatoma, we therefore suggest a possible papillomavirus etiology for the development of aggressive cholesteatoma.
authors.affiliation: HNO-Praxis, Tauberbischofsheim.
authors.forename: A
authors.initials: A
authors.lastname: Stremlau
authors.forename: J
authors.initials: J
authors.lastname: Helms
authors.forename: H K
authors.initials: HK
authors.lastname: Müller-Hermelink
authors.forename: F
authors.initials: F
authors.lastname: Hoppe
authors.forename: E M
authors.initials: EM
authors.lastname: de Villiers
mesh_terms: D001706:Biopsy; D018424:Cholesteatoma, Middle Ear / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics*; D004432:Ear, Middle / Q000473:pathology / Q000821:virology; D004848:Epithelium / Q000473:pathology / Q000821:virology; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000473:pathology* / Q000821:virology; D014412:Tumor Virus Infections / Q000473:pathology* / Q000821:virology; D014779:Virus Replication / Q000502:physiology
chemical_list: D004279:DNA, Viral
vernacular_title: Nachweis der DNS humaner Papillomviren (HPV) in einem "aggressiv" wachsenden Cholesteatom. Das Cholesteatom, ein virusinduzierter Tumor?