[The effect of angiotensin I converting enzyme inhibitors on renal function indicators in hypertensive patients].
The paper reviews the results of a preliminary study on hemodynamic and functional kidney indices in patients with hypertension with different etiopathogenesis. The investigation was carried out in 36 patients; 30 cases with no renal artery stenosis (RAS) and 6 cases with different stages of RAS. The investigation was conducted both in basal conditions and after the peroral administration of captopril (Zorcaptil à 25 mg, 1h before the examination). Kidney hemodynamics and its function were investigated by the dynamic kidney scintigraphy with the deconvolution analysis of the renogram and by the determination of the total and separate clearances 99Tcm-MAG3 and/or 99Tcm-DTPA. The obtained results lead to the conclusion that the sensitivity of the applied methodology enables differentiation of hypertensions in whose etiopathogenesis the renin-angiotensin-aldosterone system (RAAS) does not play the key role. Further investigations are needed for valid conclusions to be made.
Sedlak-Vadoc
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Institut za patolosku fiziologiju i laboratorijsku dijagnostiku, Medicinski fakultet, Novi Sad.
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D000293:Adolescent; D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006977:Hypertension, Renal / Q000188:drug therapy / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
D002216:Captopril
Uticaj inhibitora konvertujućeg enzima angiotenzina-I na funkcijske pokazatelje bubrega u hipertenzivnih bolesnika.