title: [Diagnostic and therapeutic strategy in multiple insulinoma].
abstract: Four of 59 patients with organic hyperinsulinism had multiple insulinomas and two patients a micro- and macroadenomatosis. Excluding patients with adenomatosis 3 of 10 tumors could be detected preoperatively by ultrasound (5 of 10 by CT). 6 of 7 macroadenomas could be visualized by angiography. Intraoperatively 9 of 10 macroadenomas were palpable. The nonpalpable tumor could be localized by intraoperative ultrasound. Pancreatic resection had better results than multiple enucleations. Excisional biopsy is recommended to exclude nesidioblastosis or microadenomatosis.
authors.affiliation: Klinik und Polikinik für Allgemein- und Abdominalchirurgie, Johannes-Gutenberg-Universität Mainz.
authors.forename: T
authors.initials: T
authors.lastname: Böttger
authors.forename: A
authors.initials: A
authors.lastname: Heintz
authors.forename: T
authors.initials: T
authors.lastname: Junginger
authors.forename: C
authors.initials: C
authors.lastname: Düber
authors.forename: J
authors.initials: J
authors.lastname: Beyer
mesh_terms: D007516:Adenoma, Islet Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D007340:Insulinoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D010179:Pancreas / Q000473:pathology; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*
vernacular_title: Diagnostische und therapeutische Strategie bei multiplen Insulinomen.