title: Developmentally regulated in vitro phosphorylation of cytoskeletal proteins of the cerebral cortex of normal and malnourished rats.
abstract: In this investigation we studied developmentally regulated endogenous protein kinase activity in cytoskeletal proteins in the cerebral cortex of rats and the effect of early malnutrition imposed on dams on the pattern of 32P incorporation into the cytoskeleton of pups. Our results indicated that in vitro incorporation was maximum in 7-day-old pups for both normal and malnourished groups, decreasing with development, and reaching minimum values in adult animals. However, 32P incorporation into NF-M and tubulin was significantly lower in 7-day-old malnourished pups than in normal pups.
authors.affiliation: Departamento de Bioquimica, Instituto de Biociencias, Universidade Federal do Grande do Sul, Porto Alegre, Brasil.
authors.forename: A G
authors.initials: AG
authors.lastname: de Mattos
authors.forename: M S
authors.initials: MS
authors.lastname: de Freitas
authors.forename: M M
authors.initials: MM
authors.lastname: Camargo
authors.forename: R
authors.initials: R
authors.lastname: Pessoa-Pureur
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001835:Body Weight; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000302:isolation & purification / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D009748:Nutrition Disorders / Q000378:metabolism*; D009929:Organ Size; D010750:Phosphoproteins / Q000302:isolation & purification / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D051381:Rats; D012016:Reference Values
chemical_list: D003598:Cytoskeletal Proteins; D010750:Phosphoproteins; D010761:Phosphorus Radioisotopes; D011494:Protein Kinases