Comparison of two enzyme immunoassays and two latex agglutination assays for detection of cytomegalovirus antibody.
Two commercially available enzyme immunoassays for cytomegalovirus (CMV) immunoglobulin G (IgG), Vidas and Diamedix, and two latex agglutination tests that detect both CMV IgG and IgM, CMV-Scan and CMV-Gen, were evaluated using 165 human serum specimens. Among these, 46.7% contained CMV-reactive antibody. The first three assays had sensitivities of 100%; the sensitivity of the CMV-Gen procedure was 98.7%. The specificities of the four tests were 100, 97.7, 97.3, and 93.2%, respectively.
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Clinical Microbiology Laboratories, University of Massachusetts Medical Center, Worcester 01655-0219.
Robbie
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Marrama
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D000914:Antibodies, Viral / Q000032:analysis*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis; D006801:Humans; D007124:Immunoenzyme Techniques; D007841:Latex Fixation Tests; D012680:Sensitivity and Specificity; D012698:Serologic Tests
D000914:Antibodies, Viral