title: An intrapleural lung prosthesis: rationale, design, and testing.
abstract: Extracorporeal life support (ECLS or ECMO) is standard treatment for severe respiratory failure but poses many contraindications to future lung transplantation. The solution to this dilemma is the implantable gas exchange device (IGED) or artificial lung. Preliminary efforts to create such an artificial lung have been made since 1970 and include designs involving single devices, intravascular devices (i.e., IVOX), and combination heart-lung devices. Stringent requirements govern the design of such a device, the most important of which are high gas exchange efficiency, low resistance to blood flow, and size. This paper describes such a device. It incorporates large diameter inflow and outflow ports in close proximity and a low resistance wound hollow fiber core encapsulated in a compliant outer shell which conserves the work of the right ventricle. In a large animal model (adult sheep) this device was connected in line with the main pulmonary artery in series with the native lungs. This configuration has the advantages of using the lungs as an embolic filter, perfusing the lungs with fully oxygenated blood, and maintaining the integrity of the anatomy necessary for transplant. Laboratory experiments have run > 8 h. Preliminary data show that the animals have remained hemodynamically stable while the devices have supported the animals completely by supplying 100% O2 saturation with PO2 values ranging from 250-350 mm Hg. Additionally, this model makes possible the study of respiratory failure without introducing other variables such as extracorporeal circuits or pumps. The other metabolic, endocrine, and reticuloendothelial functions of normal and injured lungs can now be studied more precisely by excluding these variables.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, University of Michigan Hospitals, Ann Arbor 48109.
authors.forename: F L
authors.initials: FL
authors.lastname: Fazzalari
authors.forename: R H
authors.initials: RH
authors.lastname: Bartlett
authors.forename: M R
authors.initials: MR
authors.lastname: Bonnell
authors.forename: J P
authors.initials: JP
authors.lastname: Montoya
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001794:Blood Pressure / Q000502:physiology; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation; D018056:Hemorheology; D008168:Lung / Q000503:physiopathology; D016040:Lung Transplantation; D008422:Materials Testing; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood; D010107:Oxygenators, Membrane; D011651:Pulmonary Artery / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D011673:Pulsatile Flow / Q000502:physiology; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000601:surgery; D012756:Sheep; D016276:Ventricular Function
chemical_list: D010100:Oxygen