title: [Treatment of primary hepatocarcinoma with chemoembolization and alcohol injection. Personal experience].
abstract: The comparative efficacy of transcatheter arterial chemoembolization and percutaneous ethanol injection (PEI) in the treatment of hepatocellular carcinoma (HCC) was investigated in a series of 243 consecutive patients: 146 of them were submitted to 1-6 chemoembolization sessions at 1 and 3 months' intervals and 30 to PEI; the remaining 67 patients refused any treatment. The follow-up ranged 3 to 36 months. Survival rates were statistically analyzed with the life table analysis. Patients' survival was affected by the number of nodules and by Child's and Okuda's classes; no relationship was found between survival rates and histologic grade or nodule vascular feeding. In case of single lesions, chemoembolization was more effective than PEI in Okuda's class I. In case of multifocal HCC, chemoembolization was better than no treatment in Okuda's class I and Child's class A. In conclusion, we suggest chemoembolization as the treatment of choice in Child A or Okuda I patients with multifocal HCCs, while its use seems of little help in Child B-C or Okuda II-III patients. In case of unifocal HCC, PEI or surgical resection should be combined with chemoembolization.
authors.affiliation: Sezione di Angiografia e Radiologia Interventistica, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia.
authors.forename: F
authors.initials: F
authors.lastname: Florio
authors.forename: M
authors.initials: M
authors.lastname: Nardella
authors.forename: S
authors.initials: S
authors.lastname: Balzano
authors.forename: A
authors.initials: A
authors.lastname: Andriulli
authors.forename: E
authors.initials: E
authors.lastname: Caturelli
authors.forename: D
authors.initials: D
authors.lastname: Siena
authors.forename: M
authors.initials: M
authors.lastname: Bisceglia
authors.forename: S
authors.initials: S
authors.lastname: Fusilli
authors.forename: M G
authors.initials: MG
authors.lastname: Scarale
authors.forename: M
authors.initials: M
authors.lastname: Cammisa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage; D015993:Life Tables; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D000431:Ethanol; D007459:Iodized Oil
vernacular_title: Trattamento dell'epatocarcinoma primitivo mediante chemioembolizzazione e alcolizzazione. Esperienza personale.