The relationship between the urinary level of some amino acids and the occurrence of metabolic diseases associated with psychic disorders.
Assays of the branched chain amino acids, of those with basic character, of phenylalanine and glutamic acid were performed in the 24 hrs urines of 50 patients with psychic disorders, ranging in age from 0 to 20 years, and in 30 normal controls. Similar investigations were carried out in the patients' parents. Abnormal levels of urinary amino acids in some of the adults suggested the existence of mutant genes in one or both parents of one or two descendents with mental handicap. The levels of urinary amino acids correlated with the severity of the predominant psychic manifestations, which were more severe in the cases with a wide deviation from normal of aminoaciduria.
Mogoş
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T
N. Paulescu Institute of Nutrition, Diabetes and Metabolic Diseases, Bucharest, Romania.
Tănase
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I
Pănuş
C
C
Mincu
I
I
D000293:Adolescent; D000328:Adult; D000592:Amino Acid Metabolism, Inborn Errors / Q000235:genetics / Q000652:urine*; D000597:Amino Acids, Branched-Chain / Q000652:urine*; D000601:Amino Acids, Essential / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018698:Glutamic Acid / Q000652:urine; D006801:Humans; D007223:Infant; D008297:Male; D001523:Mental Disorders / Q000235:genetics / Q000652:urine*; D010649:Phenylalanine / Q000652:urine
D000597:Amino Acids, Branched-Chain; D000601:Amino Acids, Essential; D018698:Glutamic Acid; D010649:Phenylalanine