Developmental expression of the lipocalin Lazarillo and its role in axonal pathfinding in the grasshopper embryo.
This article describes the expression pattern and functional analysis of Lazarillo, a novel cell surface glycoprotein expressed in the embryonic grasshopper nervous system, and a member of the lipocalin family. Lazarillo is expressed by a subset of neuroblasts, ganglion mother cells and neurons of the central nervous system, by all sensory neurons of the peripheral nervous system, and by a subset of neurons of the enteric nervous system. It is also present in a few non neuronal cells associated mainly with the excretory system. A monoclonal antibody raised against Lazarillo perturbs the extent and direction of growth of identified commissural pioneer neurons. We propose that Lazarillo is the receptor for a midline morphogen involved in the outgrowth and guidance of these neurons.
Sánchez
D
D
Biology Department, University of Utah, Salt Lake City 84112.
Ganfornina
M D
MD
Bastiani
M J
MJ
D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D002478:Cells, Cultured; D002490:Central Nervous System / Q000737:chemistry / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D006110:Grasshoppers / Q000196:embryology* / Q000235:genetics; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D019476:Insect Proteins; D007422:Intestines / Q000737:chemistry / Q000196:embryology / Q000294:innervation; D054834:Lipocalins; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D009420:Nervous System / Q000737:chemistry / Q000196:embryology* / Q000648:ultrastructure; D009474:Neurons / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D017933:Peripheral Nervous System / Q000737:chemistry / Q000196:embryology
D002352:Carrier Proteins; D019476:Insect Proteins; C092150:Lazarillo protein, Schistocerca; D054834:Lipocalins; D008562:Membrane Glycoproteins