Tau-mutant hamster SCN clock neurones express a 20 h firing rate rhythm in vitro.
In vitro neurophysiological studies have demonstrated a circadian rhythm with a period of 24 h in spontaneous neuronal discharge frequency within the rodent suprachiasmatic nucleus (SCN) circadian clock. This report examines the 'circadian' firing rate rhythm in the SCN of the homozygous Tau-mutant Syrian hamster which expresses a short period behavioural rhythm. The spontaneous SCN neuronal firing rate patterns are similar to those observed in wild types. The Tau SCN firing rate rhythm displays a peak in neuronal activity occurring 5-6 h before the predicted onset of wheel-running activity, with a peak-to-peak period of 20 h. This period of the rhythm of spontaneous neuronal discharge within the Tau-mutant SCN parallels the behavioural free-running period of 20 h.
Davies
I R
IR
Department of Physiology and Pharmacology, University of Nottingham Medical School, Queens Medical Centre, UK.
Mason
R
R
D000200:Action Potentials / Q000235:genetics; D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics*; D006224:Cricetinae; D005838:Genotype; D006720:Homozygote; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D009154:Mutation; D009474:Neurons / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000502:physiology*