Distribution of high density lipoprotein binding proteins among various tissues in the rat.
Levels of high density lipoprotein (HDL) in the blood are negatively correlated with heart disease and factors which regulate the levels and metabolism of this important lipoprotein are being investigated by many laboratories. Following the identification in liver of two candidate HDL receptors, HB1 and HB2, we undertook in the present studies, an examination of various other rat tissues for the identification of similar proteins. Using specific antibodies against each of the binding proteins, we identified both HB1 and HB2 in several other tissues (intestine, lung, kidney, ovary ...) and further, revealed relative differences in the expression of HB1 and HB2 between various tissues. A most interesting observation was the presence of HB1 but not HB2 in the spleen. Since the two proteins are not represented equally in all tissues, it is conceivable that these putative receptors have different functions in HDL metabolism or in other biological processes yet to be determined.
Lutton
C
C
Laboratoire de Physiologie de la Nutrition, Université Paris-XI, Orsay, France.
Fidge
N
N
D000818:Animals; D005260:Female; D015151:Immunoblotting; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018110:Receptors, Lipoprotein / Q000378:metabolism*; D014018:Tissue Distribution
D008075:Lipoproteins, HDL; D018110:Receptors, Lipoprotein