title: The human serotonin 5-hydroxytryptamine1D receptor pseudogene is transcribed.
abstract: An examination of mRNA expression of the serotonin genes encoding both psi 5HT1D alpha and the related 5HT1D alpha, demonstrated that the pseudogene is transcribed, and has a tissue distribution similar to the 5HT1D alpha receptor-encoding gene. This psi 5HT1D alpha transcript is capable of being translated into a polypeptide of only 28 amino acids in length, and the psi 5HT1D alpha pseudogene most likely arose from a gene duplication or transposition event.
authors.affiliation: Synaptic Pharmaceutical Corporation, Paramus, NJ 07652.
authors.forename: J A
authors.initials: JA
authors.lastname: Bard
authors.forename: S P
authors.initials: SP
authors.lastname: Nawoschik
authors.forename: B F
authors.initials: BF
authors.lastname: O'Dowd
authors.forename: S R
authors.initials: SR
authors.lastname: George
authors.forename: T A
authors.initials: TA
authors.lastname: Branchek
authors.forename: R L
authors.initials: RL
authors.lastname: Weinshank
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D009928:Organ Specificity; D014176:Protein Biosynthesis; D011544:Pseudogenes / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin