title: DU-6859a, a new fluoroquinolone agent. Comparative in vitro activity against enteric pathogens and multiresistant outpatient Escherichia coli.
abstract: The activity of DU-6859a, a new fluoroquinolone antimicrobial agent, was compared with that of ciprofloxacin by agar dilution susceptibility testing against enteric pathogens and multiresistant Escherichia coli. The results indicate that DU-6859a inhibits most of these organisms at concentrations similar to those of ciprofloxacin. DU-6859a showed increased activity compared to ciprofloxacin against Campylobacter species isolates.
authors.affiliation: Department of Internal Medicine, University of Texas Medical School at Houston 77030.
authors.forename: J F
authors.initials: JF
authors.lastname: Tomayko
authors.forename: V
authors.initials: V
authors.lastname: Korten
authors.forename: B E
authors.initials: BE
authors.lastname: Murray
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D003967:Diarrhea / Q000188:drug therapy; D018432:Drug Resistance, Multiple; D004926:Escherichia coli; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D013141:Spiro Compounds / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D013141:Spiro Compounds; D002939:Ciprofloxacin; C076246:sitafloxacin