title: Acute and chronic toxicity of "Polfa" perphenazine.
abstract: The toxicity of "Polfa" perphenazine and its profile of pharmacological properties were estimated. LD50 values calculated in rats were 2000 mg/kg and 325 mg/kg, after p.o. and i.p. administration respectively. Chronic toxicity of the perphenazine was evaluated during the period of 3 month of the drug treatment p.o. or i.p. in the rats and mice. Decrease of the locomotor activity of perphenazine was observed after the highest dose (15 mg/kg) of the drug, only in the first weeks of the experiment. Also the cataleptogenic effect of perphenazine observed in the mice was diminished during 3 month of the experiment. Moreover, perphenazine did not induced significant changes in the blood morphology and histology of the internal organs.
authors.affiliation: Department of Pharmacology, School of Medicine, Lublin, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: G
authors.initials: G
authors.lastname: Rajtar
authors.forename: D
authors.initials: D
authors.lastname: Chibowski
authors.forename: Z
authors.initials: Z
authors.lastname: Siezieniewska
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010546:Perphenazine / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010546:Perphenazine