[Role of chemoprophylaxis in the prevention of invasive aspergillosis].
Invasive aspergillosis remains a severe infection, and the mortality is high, specially in some patients such as bone marrow transplants. Prophylaxis may be considered either in patients without previous aspergillosis, or in patients cured from previous aspergillosis and exposed again to immunosuppression. The efficacy of prophylaxis may be difficult to demonstrate, due to the relatively low incidence of aspergillosis and the possible lack of proven mycologic diagnosis. The different possibilities of prophylaxis (systemic antifungal treatment, local therapy) will be discussed.
Joly
V
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Service de Médecine Interne, Hôpital Bichat, Paris, France.
D000336:Aerosols; D000666:Amphotericin B / Q000627:therapeutic use*; D001228:Aspergillosis / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000517:prevention & control*; D008297:Male
D000336:Aerosols; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine
Place de la chimioprophylaxie dans la prévention de l'aspergillose invasive.