title: Technetium-99m sestamibi tomographic evaluation of residual ischemia after anterior myocardial infarction.
abstract: OBJECTIVE
  This study investigated the value of sestamibi scintigraphy in assessing residual ischemia after anterior myocardial infarction.
  
  
  BACKGROUND
  Serial imaging with sestamibi, the uptake and retention of which correlate with regional myocardial blood flow and viability, has been used to estimate salvaged myocardium and risk area after acute infarction. We recently documented that recovery of perfusion and contraction in the infarcted area may continue well after the subacute phase, suggesting myocardial hibernation. Some underestimation of viability in the setting of hibernating myocardium by sestamibi imaging has been reported.
  
  
  METHODS
  We studied 58 patients in stable condition after Q wave anterior infarction. Regional perfusion and function were quantitatively assessed by sestamibi tomography and two-dimensional echocardiography at 4 to 6 weeks and at 7 months after infarction. In sestamibi polar maps, abnormal areas with tracer uptake > 2.5 SD below our reference values were computed at rest and after symptom-limited exercise. On two-dimensional echocardiography the ejection fraction and extent of rest wall motion abnormalities were assessed by a computerized system. All patients had coronary angiography between the two studies.
  
  
  RESULTS
  At 7 months the extent of rest sestamibi defect was significantly reduced in 40 patients (69%, group 1) and unchanged in 18 (31%, group 2). Rest wall motion abnormalities and ventricular ejection fraction significantly improved in group 1 but not in group 2. Underlying coronary disease, patency of the infarct-related vessel and rest sestamibi defect extent at 5 weeks were comparable between the two groups. At 7 months, an increase in the reversible (stress-rest defect) tracer defect was observed in group 1 (p < 0.05) despite a smaller stress-induced hypoperfusion (p < 0.05). Reversible sestamibi defects and stress hypoperfusion were unchanged in group 2. In 38 (95%) of 40 group 1 patients, the area showing reversible sestamibi defects at 7 months matched the area showing fixed hypoperfusion at 5 weeks.
  
  
  CONCLUSIONS
  The reduction in the rest tracer uptake defect that can occur late after infarction may affect the assessment of ischemic burden by sestamibi imaging early after anterior myocardial infarction.
authors.affiliation: Cardiology Division, Clinica del Lavoro Foundation, Istituto Ricovero e Cura a Carattere Scientifico (IRCCS), Veruno, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Marcassa
authors.forename: M
authors.initials: M
authors.lastname: Galli
authors.forename: P L
authors.initials: PL
authors.lastname: Temporelli
authors.forename: R
authors.initials: R
authors.lastname: Campini
authors.forename: P S
authors.initials: PS
authors.lastname: Orrego
authors.forename: O
authors.initials: O
authors.lastname: Zoccarato
authors.forename: A
authors.initials: A
authors.lastname: Giordano
authors.forename: P
authors.initials: P
authors.lastname: Giannuzzi
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004452:Echocardiography; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi
chemical_list: D017256:Technetium Tc 99m Sestamibi