title: The effects of doxazosin on plasma lipid and lipoprotein levels in hypertensive patients.
abstract: Plasma lipid and lipoprotein levels were evaluated in 27 adults with essential hypertension at four different periods during a 12-month treatment with doxazosin. Mean plasma total cholesterol (TC), low-density lipoprotein-cholesterol (LDLC), triglyceride (TG), very low density lipoprotein-cholesterol (VLDLC) and the LDLC/HDLC ratio were significantly reduced following doxazosin therapy. The HDLC/C ratio was found to be increased, while mean high density lipoprotein cholesterol (HDLC) level remained unchanged at 3, 6, 9 and 12 months of measurement after doxazosin treatment. Our data showed that the duration of doxazosin treatment did not influence the observed favourable lipid changes; but TC and LDLC appear to be the lipid fractions most affected by doxazosin in all the patients. In order to determine the possible factors responsible for the lipid-altering actions of doxazosin treatment, we observed beneficial lipid and lipoprotein changes in both the male and female subpopulations of patients with a slightly higher magnitude in the females. The dosage of doxazosin was, however, found to have no influence on the lipid-altering actions; a further study was therefore recommended.
authors.affiliation: Department of Chemical Pathology, College of Health Sciences, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.
authors.forename: J E
authors.initials: JE
authors.lastname: Ahaneku
authors.forename: G O
authors.initials: GO
authors.lastname: Taylor
authors.forename: E O
authors.initials: EO
authors.lastname: Agbedana
authors.forename: O
authors.initials: O
authors.lastname: Walker
authors.forename: L A
authors.initials: LA
authors.lastname: Salako
mesh_terms: D000328:Adult; D044383:Black People; D002784:Cholesterol / Q000097:blood*; D017292:Doxazosin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
chemical_list: D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol; D017292:Doxazosin