title: Change in serum concentration of insulin-like growth factor II (IGF-II) in patients with thyroid disease.
abstract: We investigated the serum concentration of IGF-II in patients with thyroid diseases (25 with untreated Graves' patients, 30 with hypothyroidism, 23 with thyroid adenoma) and in 72 healthy adults as normal controls, by a sensitive radioimmunoassay of serum IGF-II. Thyroid hormones are known to increase IGF-I production in the liver through the enhancement of GH secretion. In case of IGF-II, however, knowledge has been rather limited. The mean +/- SD concentration in healthy subjects was 556 +/- 94 micrograms/L with neither sex nor age dependence. In untreated Graves' patients, serum IGF-II levels (675 +/- 129 micrograms/L) were significantly (P < 0.01) higher than in normal controls, and significantly lower in patients with hypothyroidism (460 +/- 106 micrograms/L; P < 0.01). Thyroid hormones revealed positive correlation with the IGF-II concentration.
authors.affiliation: Department of Laboratory Medicine, Osaka University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tada
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Futakuchi
authors.forename: N
authors.initials: N
authors.lastname: Amino
mesh_terms: D000328:Adult; D005260:Female; D006111:Graves Disease / Q000378:metabolism*; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D007335:Insulin-Like Growth Factor II