[Abnormalities of anti-oncogene p53 in renal cell carcinoma].
Mutant forms of p53 gene are found in numerous human malignancies. Studies of the p53 mRNA showed different levels of expression in many tumours. But the relationship between the p53 gene and the renal cell carcinoma is less elucidated than the other. In this report we examined p53 gene at mRNA level by Northern blot on the tissues from 21 patients with renal cell carcinoma. Abnormalities of the p53 were found in 12(57%) tumors, in which seven had elevated level of p53 mRNA, and five lacked p53 mRNA. p53 gene alteration occurred in a high percentage in high-grade and advanced tumors. These results suggest that inactivation of p53 gene is common in renal cell carcinoma and may be involved in the progression of this malignancy.
Li
M
M
Institute of Urology, Beijing Medical University.
Gu
F L
FL
Li
W B
WB
D015152:Blotting, Northern; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D017353:Gene Deletion; D015870:Gene Expression; D016158:Genes, p53; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*
D012333:RNA, Messenger