Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.
CD4+ T cells play a key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them.
Liblau
R S
RS
Dept of Microbiology and Immunology, Stanford University School of Medicine, CA 94305-5402.
Singer
S M
SM
McDevitt
H O
HO
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*