Effect of increased depletion of copper, supplementary cholesterol diet and stress on the cholesterol concentration in wall of rat thoracic aorta.
The effects of experimental copper deficiency by itself, and in combination with other factor resulting in ischaemic heart diseases (IHD), were investigated on the lipid composition and copper status of serum and aortic wall in rat. The depletion of absorbed copper was raised by complex formation (D-penicillamine-treatment). This provoked secondary copper deficiency was combined with a dietary cholesterol- and stress-loading. After treatment the levels of triglyceride (Tg), total cholesterol (Chol), HDL-cholesterol (HDL) (HDL = high density lipoprotein) and HDL2-cholesterol (HDL2) as well as copper (Cu) and zinc (Zn) in the serum and in aortic wall were measured by chemical analysis. It was pointed out, that increase in triglyceride and total cholesterol levels were promoted by the provoked copper deficiency in the serum and in the wall of the thoracic aorta. In combination with other risk factors it caused an increase in the elevation of Tg and Chol concentrations and has reduced the level of HDL2, significantly.
Tóth
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Aeromedical Research Institute, Kecskemét, Hungary.
Remes
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D000818:Animals; D001013:Aorta, Thoracic / Q000737:chemistry*; D002784:Cholesterol / Q000032:analysis*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D003300:Copper / Q000097:blood / Q000172:deficiency*; D008297:Male; D017202:Myocardial Ischemia / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors; D013312:Stress, Physiological / Q000503:physiopathology*; D014280:Triglycerides / Q000032:analysis; D015032:Zinc / Q000032:analysis
D002791:Cholesterol, Dietary; D014280:Triglycerides; D003300:Copper; D002784:Cholesterol; D015032:Zinc