The effect of actinomycin D on the megakaryocytic line in rat.
Four-day administration of actinomycin D to the albino rat in daily doses of 25 micrograms/kg decreased--in relation to all blood cells of the bone marrow--the values of the more mature stages of the megakaryocytic line, i.e. megakaryocytes and naked megakaryocyte nuclei. The number of megakaryoblasts was not influenced.
Janoutová
J
J
Institute of Histology and Embryology, 3rd Medical Faculty, Charles University, Praha, Czech Republic.
Likovský
Z
Z
D000818:Animals; D002452:Cell Count; D003609:Dactinomycin / Q000494:pharmacology*; D008297:Male; D008533:Megakaryocytes / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D003609:Dactinomycin