title: [Two cases of adult T-cell leukemia . lymphoma (ATL) with long-term remission by chronic daily administration of low-dose etoposide].
abstract: We tried long-term oral administration of low-dose etoposide (LDE) for seven patients with adult T-cell leukemia . lymphoma (ATL) at Asahikawa Red Cross Hospital in 1988. Two long-term survivors are presented. Case 1: A 53-year-old man was diagnosed as acute ATL in 1987. Because VEPA therapy was not effective, LDE (50 mg/day) therapy was started. Five months after entering CR, a lymphoma recurrence in the skin was observed. Retreatment with LDE and radiation therapy was effective, but he died of reprogression of ATL three years and seven months following initial diagnosis. Case 2: A 43-year-old woman was diagnosed as acute ATL in 1989. With LDE (50 mg/day) therapy for 40 days, she entered CR. The lymphoma recurred in the central nervous system (CNS) and skin in 1992. After radiation of CNS and LDE therapy, she showed CR again. She is alive now over five years and eight months after diagnosis.
authors.affiliation: Dept. of Internal Medicine, Asahikawa Red Cross Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Ezoe
authors.forename: K
authors.initials: K
authors.lastname: Kohda
authors.forename: Y
authors.initials: Y
authors.lastname: Hirayama
authors.forename: A
authors.initials: A
authors.lastname: Nobuoka
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: O
authors.initials: O
authors.lastname: Nakazawa
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Muramatsu
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
mesh_terms: D000284:Administration, Oral; D000328:Adult; D016543:Central Nervous System Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000532:radiotherapy
chemical_list: D005047:Etoposide