Isolation and structures of an antifungal antibiotic, fusarielin A, and related compounds produced by a Fusarium sp.
A new antifungal antibiotic, fusarielin A, and three related compounds, fusarielins B, C and D, were obtained from a culture of a Fusarium sp. The skeletal structure and the relative stereochemistry of fusarielin A were determined mainly on the basis of its NMR data, and the absolute structure was elucidated by using the exciton chirality method and the modified Mosher method. The structures of the other homologues were determined by comparison of their spectral data with those of fusarielin A.
Kobayashi
H
H
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Sunaga
R
R
Furihata
K
K
Morisaki
N
N
Iwasaki
S
S
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects / Q000378:metabolism; D005670:Fusarium / Q000737:chemistry* / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008868:Microtubule Proteins / Q000096:biosynthesis / Q000187:drug effects; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011522:Protons; D013237:Stereoisomerism; D013552:Swine
D000935:Antifungal Agents; D002247:Carbon Isotopes; D004852:Epoxy Compounds; D008868:Microtubule Proteins; D009281:Naphthalenes; D011522:Protons; C092174:fusarielin A; C092175:fusarielin B; C092176:fusarielin C; C092177:fusarielin D