title: [BCG vaccination and increasing the effectiveness of treatment of post-vaccination complications by the use of rifampicin and dimexide].
abstract: The results of treatment for postvaccination complications were compared in 287 children (125 patients with regional lymphadenitis and 162 patients with cold abscesses). The treatment included local applications of rifampicin and dimexide solutions. Postvaccination lymphadenitis occurred significantly more frequently in children receiving BCG vaccine versus those receiving BCG-M vaccine with diminished antigenic load. Local applications of rifampicin+dimexide solution as an adjuvant treatment to isoniazid therapy of abscessed lymphadenitis permit the physician to reduce the number of puncture administration of 5% saluzid solution and decrease 2-fold the treatment duration. Similar results were obtained for cold abscess treatment. Rifampicin+dimexide applications to treat postvaccination complications in the form of lymphadenitis and cold abscesses in infiltration phase do not require local administration of saluzid, oral isoniazid. The complete resorption is reached within 1-2 months.
authors.forename: L A
authors.initials: LA
authors.lastname: Mitinskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Iukhimenko
authors.forename: V F
authors.initials: VF
authors.lastname: Kamaeva
mesh_terms: D000038:Abscess / Q000188:drug therapy / Q000209:etiology; D001500:BCG Vaccine / Q000009:adverse effects*; D002648:Child; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D004338:Drug Combinations; D006801:Humans; D007231:Infant, Newborn; D007538:Isoniazid / Q000008:administration & dosage / Q000031:analogs & derivatives; D008199:Lymphadenitis / Q000188:drug therapy / Q000209:etiology; D012293:Rifampin / Q000008:administration & dosage*; D012996:Solutions; D013997:Time Factors
chemical_list: D001500:BCG Vaccine; D004338:Drug Combinations; D012996:Solutions; C009200:saluzid; D007538:Isoniazid; D012293:Rifampin; D004121:Dimethyl Sulfoxide
vernacular_title: Vaktsinatsiia BTsZh i povyshenie éffektivnosti lecheniia postvaktsinal'nykh oslozhneniĭ s primeneniem applikatsiĭ rifampitsina s dimeksidom.