title: [Adrenal insufficiency and antiphospholipid syndrome].
abstract: We report a case of acute adrenal insufficiency secondary to bilateral adrenal hemorrhage, in a 53 year old patient, occurring in the post-operative course of a lower limb ischemia. The patient was found to have a lupus anticoagulant, and it was concluded that the adrenal insufficiency was related to a primary antiphospholipid syndrome (PAPS). The PAPS is a cause of both, acute and chronic adrenal insufficiency. Endocrinologists are relatively little familiar with this etiology. Pathophysiologically, thrombosis and bilateral adrenal hemorrhage can result in progressive bilateral adrenal atrophy, requiring life long substitution. Therefore, the importance to search for antiphospholipid antibodies in the evaluation of acute and chronic adrenal insufficiency has to be emphasized.
authors.affiliation: Service de Nutrition, Maladies Métaboliques, Endocrinologie, CHU Timone, Marseille.
authors.forename: M A
authors.initials: MA
authors.lastname: Christofilis
authors.forename: P
authors.initials: P
authors.lastname: Silvestre-Aillaud
authors.forename: P
authors.initials: P
authors.lastname: Piquet
authors.forename: M C
authors.initials: MC
authors.lastname: Aillaud
authors.forename: B
authors.initials: B
authors.lastname: Vialettes
mesh_terms: D000208:Acute Disease; D000307:Adrenal Gland Diseases / Q000150:complications; D000309:Adrenal Insufficiency / Q000209:etiology* / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis; D016063:Blood Loss, Surgical; D006801:Humans; D007511:Ischemia / Q000601:surgery; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
chemical_list: D017152:Antibodies, Antiphospholipid
vernacular_title: Insuffisance surrénalienne et syndrome des antiphospholipides.