A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia.
A novel class of conserved transcription factors has been identified from the molecular cloning of AF10, the gene involved in the t(10;11)(p12;q23) translocation of acute myeloid leukemias. AF10 encodes a 109-kD protein of 1,027 amino acids and contains an N-terminal zinc finger region and a C-terminal leucine zipper. These structures have been found to be conserved in sequence and position in three other proteins, AF17, BR140, and a previously unrecognized Caenorhabditis elegans gene, provisionally named CEZF. The overall structure, level of sequence conservation, and expression pattern suggest that these genes encode a new class of transcription factors, some of which are targets for chromosomal translocation in acute leukemia.
Chaplin
T
T
Department of Medical Oncology, St Bartholomew's Hospital Medical College, London, UK.
Ayton
P
P
Bernard
O A
OA
Saha
V
V
Della Valle
V
V
Hillion
J
J
Gregorini
A
A
Lillington
D
D
Berger
R
R
Young
B D
BD
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D001483:Base Sequence; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins; D006801:Humans; D016350:Leucine Zippers / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic; D016335:Zinc Fingers / Q000235:genetics*; D000092468:Bromodomain Containing Proteins
D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C086011:BRPF1 protein, human; D000092468:Bromodomain Containing Proteins; C092513:MLLT10 protein, human; C096106:MLLT6 protein, human