[The mechanisms of binding of active drugs to polyalkylcyanoacrylate nanoparticles].
Studies on colloidal carriers such as nanoparticles are generally based on the evaluation of the optimal amount of drug linked to the polymer matrix. This figure is obtained through the mathematical treatment of adsorption/incorporation isotherms. However, results of the literature show an obvious heterogeneity in the isotherms mathematical treatment. A theoretical review of the potential models of the sorption process of drugs will be used to compare the results previously published in the literature. An experimental and systematic approach will be proposed in order to compare more easily the studies from the different research teams and to evaluate the interactions between drugs and colloidal carriers.
Martin
J
J
Laboratoire de Chimie Minérale, Faculté des Sciences Pharmaceutiques et Biologiques, Nancy, France.
Macchi
P
P
Hoffman
M
M
Maincent
P
P
D002626:Chemistry, Pharmaceutical; D003487:Cyanoacrylates / Q000737:chemistry*; D004337:Drug Carriers; D008863:Microspheres
D003487:Cyanoacrylates; D004337:Drug Carriers
Etude des mécanismes de fixation des principes actifs sur les nanoparticules de polyalkylcyanoacrylate.