Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.
Chegwidden
W R
WR
Division of Biomedical Sciences, Sheffield Hallam University, England.
Wagner
L E
LE
Venta
P J
PJ
Bergenhem
N C
NC
Yu
Y S
YS
Tashian
R E
RE
D002256:Carbonic Anhydrases / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D004789:Enzyme Activation / Q000235:genetics; D006801:Humans; D006868:Hydrolysis; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D015032:Zinc / Q000378:metabolism*
D002256:Carbonic Anhydrases; D015032:Zinc