Growth of Cryptococcus neoformans in presence of L-dopa decreases its susceptibility to amphotericin B.
Cryptococcus neoformans grown with L-dopa was melanized and was less susceptible to amphotericin B. The results suggest that in vivo and in vitro susceptibilities to amphotericin B may differ.
Wang
Y
Y
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Casadevall
A
A
D000666:Amphotericin B / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D007980:Levodopa / Q000494:pharmacology*; D008543:Melanins / Q000096:biosynthesis; D008826:Microbial Sensitivity Tests
D008543:Melanins; D007980:Levodopa; D000666:Amphotericin B