Autoclaving of liposomes.
The attempt was made to study liposome stability and oxidation under the autoclaving conditions. It was shown that after the preliminary air removal from a liposome sample there was no lipid oxidation (malonaldehyde bis(dimethyl acetate) was used as a control) and liposome content leakage during autoclaving. Liposomes with entrapped Intal remain completely intact after autoclaving for 15 min at 120 degrees C.
Lukyanov
A N
AN
Institute of Experimental Cardiology, Moscow, Russia.
Torchilin
V P
VP
D004355:Drug Stability; D006361:Heating; D008081:Liposomes / Q000737:chemistry*; D010084:Oxidation-Reduction; D013242:Sterilization
D008081:Liposomes