title: Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
abstract: A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients.
authors.affiliation: Richard Dimbleby/ICRF Laboratory, St. Thomas' Hospital, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Dorudi
authors.forename: A M
authors.initials: AM
authors.lastname: Hanby
authors.forename: R
authors.initials: R
authors.lastname: Poulsom
authors.forename: J
authors.initials: J
authors.lastname: Northover
authors.forename: I R
authors.initials: IR
authors.lastname: Hart
mesh_terms: D015820:Cadherins / Q000096:biosynthesis* / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D017403:In Situ Hybridization; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D015820:Cadherins; D012333:RNA, Messenger