title: [The mechanisms of the development of pregnancy complications in hypertension and glomerulonephritis].
abstract: Pregnancy complications have been analyzed in 124 females suffering from essential hypertension (EH) and chronic glomerulonephritis (CGN). Such complications, as late gestosis (8.9%), ablation placentae (1.6%), premature delivery (14.5%), intrauterine growth retardation (14.5%) occurred more frequently than in population. Pre- and perinatal deaths were encountered with the same frequency as in the population. Morphologically, the placentas had in many cases histological evidence of moderate placental insufficiency (PI). In more than 60% of the patients there were uteroplacental and fetoplacental hemodynamic defects. Placental circulatory disorders and PI ran subclinically in most of the cases as they were compensated. In EH and CGN pregnant women, compared to healthy controls, red cells acquired abnormal forms more frequently, serum thromboxane B2 levels got elevated, lactate hydrogenase activity became enhanced. Erythrocytic damage and platelet activation in EH and CGN pregnant women may indirectly confirm the existence of systemic angiopathy. It is suggested that ischemic placenta may produce endothelial toxin, that systemic endothelial damage in EH, CGN, PI may be synergetic which potentiates its clinical appearance in the form of the above pregnancy complications.
authors.forename: V A
authors.initials: VA
authors.lastname: Rogov
authors.forename: I E
authors.initials: IE
authors.lastname: Tareeva
authors.forename: I S
authors.initials: IS
authors.lastname: Sidorova
authors.forename: A P
authors.initials: AP
authors.lastname: Milovanov
authors.forename: G I
authors.initials: GI
authors.lastname: Kozinets
authors.forename: I O
authors.initials: IO
authors.lastname: Makarov
authors.forename: N L
authors.initials: NL
authors.lastname: Kozlovskaia
authors.forename: V B
authors.initials: VB
authors.lastname: Artem'eva
authors.forename: I N
authors.initials: IN
authors.lastname: Ponomarenko
authors.forename: Z E
authors.initials: ZE
authors.lastname: Miakina
mesh_terms: D002908:Chronic Disease; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000473:pathology; D005333:Fetus / Q000098:blood supply; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000473:pathology; D010920:Placenta / Q000098:blood supply / Q000473:pathology; D021041:Placental Circulation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology* / Q000473:pathology; D011256:Pregnancy Outcome
vernacular_title: Mekhanizmy razvitiia oslozhneniĭ beremennosti pri gipertonicheskoĭ bolezni i glomerulonefrite.