title: Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection.
abstract: From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.
authors.affiliation: Department of Medical Microbiology, University of Nairobi, Kenya.
authors.forename: O A
authors.initials: OA
authors.lastname: Anzala
authors.forename: N J
authors.initials: NJ
authors.lastname: Nagelkerke
authors.forename: J J
authors.initials: JJ
authors.lastname: Bwayo
authors.forename: D
authors.initials: D
authors.lastname: Holton
authors.forename: S
authors.initials: S
authors.lastname: Moses
authors.forename: E N
authors.initials: EN
authors.lastname: Ngugi
authors.forename: J O
authors.initials: JO
authors.lastname: Ndinya-Achola
authors.forename: F A
authors.initials: FA
authors.lastname: Plummer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D015497:HIV-1; D006801:Humans; D011477:Sex Work