title: Response of adenosquamous carcinoma of the pancreas to interferon-alpha, tumor necrosis factor-alpha and 5-fluorouracil combined treatment.
abstract: A 48-year-old woman with a nonresectable pancreatic tumor received combination chemotherapy with cytokines (IFN-a plus TNF-a) and 5-FU. Since partial response was confirmed after seven months, she underwent re-exploration, and received a pancreatico-duodenectomy. Histologically, the tumor was an adenosquamous carcinoma of the pancreas. She recovered uneventfully. However, the tumor rapidly recurred, and she died five months after surgery. Despite the poor result, the survival of the patient with advanced pancreatic cancer for twelve months after the staring of the treatment suggests that combined chemotherapy with cytokines and 5-FU may be a therapeutic modality for advanced pancreatic cancer.
authors.affiliation: First Department of Surgery, Okayama University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Ohoida
authors.forename: T
authors.initials: T
authors.lastname: Matuno
authors.forename: A
authors.initials: A
authors.lastname: Gouchim
authors.forename: H
authors.initials: H
authors.lastname: Iwagaki
authors.forename: L F
authors.initials: LF
authors.lastname: Moreira
authors.forename: K
authors.initials: K
authors.lastname: Orita
mesh_terms: D018395:CA-19-9 Antigen / Q000097:blood; D018196:Carcinoma, Adenosquamous / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*
chemical_list: D018395:CA-19-9 Antigen; D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha; D005472:Fluorouracil