title: Leflunomide (HWA 486) and its analog suppress T- and B-cell proliferation in vitro, acute rejection, ongoing rejection, and antidonor antibody synthesis in mouse, rat, and cynomolgus monkey transplant recipients as well as arterial intimal thickening after balloon catheter injury.
authors.affiliation: Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA 94305-5247.
authors.forename: R E
authors.initials: RE
authors.lastname: Morris
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.forename: W
authors.initials: W
authors.lastname: Cao
authors.forename: B
authors.initials: B
authors.lastname: Zheng
authors.forename: R A
authors.initials: RA
authors.lastname: Shorthouse
mesh_terms: D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects / Q000473:pathology; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002404:Catheterization / Q000009:adverse effects; D003437:Crotonates; D016572:Cyclosporine / Q000627:therapeutic use; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects* / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology*; D000077339:Leflunomide; D008213:Lymphocyte Activation / Q000187:drug effects*; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009570:Nitriles; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014052:Toluidines; D014184:Transplantation, Homologous; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
chemical_list: D000814:Aniline Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003437:Crotonates; D006885:Hydroxybutyrates; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D009570:Nitriles; D014052:Toluidines; C527525:teriflunomide; D016572:Cyclosporine; D000077339:Leflunomide