title: Early helper T-cell dysfunction in simian immunodeficiency virus but not in human immunodeficiency virus type-2-infected macaques.
abstract: Both naive and vaccinated macaques acquired a virus-specific proliferative helper T-cell reactivity in response to infection with the nonpathogenic human immunodeficiency virus type 2 (HIV-2). In contrast, macaques infected with the pathogenic simian immunodeficiency virus of the macaque strain (SIVmac) did not develop a helper T-cell response. Furthermore, a vaccine-induced preexisting T-cell reactivity was abrogated after SIVmac infection in vaccine failures. These differences may reflect the different pathogenicity of the two closely related viruses.
authors.affiliation: Deutsches Primatenzentrum, Abteilung Virologie und Immunologie, Göttingen, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Dittmer
authors.forename: W
authors.initials: W
authors.lastname: Lüke
authors.forename: C
authors.initials: C
authors.lastname: Stahl-Hennig
authors.forename: C
authors.initials: C
authors.lastname: Coulibaly
authors.forename: H
authors.initials: H
authors.lastname: Petry
authors.forename: W
authors.initials: W
authors.lastname: Bodemer
authors.forename: G
authors.initials: G
authors.lastname: Hunsmann
authors.forename: G
authors.initials: G
authors.lastname: Voss
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015498:HIV-2 / Q000276:immunology*; D016130:Immunophenotyping; D008213:Lymphocyte Activation; D008252:Macaca fascicularis; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D013997:Time Factors; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D014765:Viral Vaccines