title: Hepatic function tests in children with sickle cell anaemia during vaso occlusive crisis.
abstract: Thirty children with sickle cell anaemia had their serum alanine aminotransferase, alkaline phosphatase, total protein, albumin and bilirubin, assayed during vaso-occlusive crisis and at recovery. Alanine aminotransferase, alkaline phosphatase and bilirubin levels were significantly higher during crisis than at recovery, (p < 0.005) especially in the young patient. However, the total protein and albumin levels were not significantly different in crisis and at recovery. A transient hepatic functional derangement during vaso-occlusive crisis is a probable explanation for the reported changes.
authors.affiliation: Department of Child Health, University of Ilorin, Nigeria.
authors.forename: A
authors.initials: A
authors.lastname: Ojuawo
authors.forename: M A
authors.initials: MA
authors.lastname: Adedoyin
authors.forename: D
authors.initials: D
authors.lastname: Fagbule
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D000418:Albumins / Q000032:analysis; D000469:Alkaline Phosphatase / Q000097:blood; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications / Q000201:enzymology; D001663:Bilirubin / Q000097:blood; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000201:enzymology / Q000209:etiology; D001798:Blood Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008111:Liver Function Tests; D008297:Male
chemical_list: D000418:Albumins; D001798:Blood Proteins; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin