Translocation (1;14)(p34;q11) and trisomy 8 in a T-cell acute lymphoblastic leukemia patient.
A case of T-cell acute lymphoblastic leukemia (T-ALL) in a 25-year-old man cytogenetically characterized by a t(1;14)(p34;q11) and trisomy 8 is reported. These chromosome abnormalities were observed in 82% of the analyzed metaphases. Fluorescence in situ hybridization (FISH) with a probe for the centromere of chromosome 8 was used to correlate cellular morphology in bone marrow (BM) cells with May-Grünwald-Giemsa smears and the cytogenetic alterations. By FISH analysis, trisomy 8 (and presumably the associated t[1;14]) was demonstrated only in lymphoid blast cells but not in the rest of the cells belonging to other hematopoietic lineages.
Martín-Henao
G A
GA
Departamento de Hematología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Sureda
A
A
D000328:Adult; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy / Q000235:genetics*