Isoelectric restriction of human immunoglobulin isotypes.
The partition of human serum immunoglobulins along a pH gradient of ampholynes was investigated using the recently developed method of preparative isoelectrofocusing. Each isotype was demonstrated to display a specific pI range, with limited overlapping. IgA appear to be the most acidic serum immunoglobulins while IgG are clearly basic.
Prin
C
C
Laboratoire d'Immunologie, Faculté de Médecine de Nancy, Vandoeuvre Les Nancy, France.
Bene
M C
MC
Gobert
B
B
Montagne
P
P
Faure
G C
GC
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007132:Immunoglobulin Isotypes / Q000737:chemistry*; D007525:Isoelectric Focusing; D007526:Isoelectric Point; D008297:Male; D008875:Middle Aged
D007132:Immunoglobulin Isotypes