title: Minocycline hydrochloride hyperpigmentation complicating treatment of pyoderma gangrenosum.
abstract: Minocycline-associated hyperpigmentation is an uncommon side effect. We report the case of a patient with pyoderma gangrenosum successfully treated with oral minocycline but complicated by marked hyperpigmentation in his pyoderma gangrenosum and acne scars. One of the clinical forms of minocycline hyperpigmentation includes dark-blue or black macules in depressed acne scars or other sites of skin inflammation; this pattern seems to be independent of the total cumulative dose and the skin process.
authors.affiliation: Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcala De Henares, Madrid, Spain.
authors.forename: E S
authors.initials: ES
authors.lastname: Miralles
authors.forename: M
authors.initials: M
authors.lastname: Nuñez
authors.forename: B
authors.initials: B
authors.lastname: Pérez
authors.forename: A
authors.initials: A
authors.lastname: Ledo
mesh_terms: D000328:Adult; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced*; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D017511:Pyoderma Gangrenosum / Q000188:drug therapy*
chemical_list: D008911:Minocycline