Basic fibroblast growth factor increases cortical blood flow in vivo.
Basic FGF has recently been shown to produce systemic and cerebral vasodilation. To test the hypothesis that bFGF increases regional cortical blood flow (rCBF), rCBF and brain pHi were measured while bFGF or vehicle was superperfused onto the cortex of rabbits. The results of this study demonstrate that topical application of bFGF causes an increase in rCBF.
Regli
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Thoralf M. Sundt Jr. Neurosurgical Research Laboratory, Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905.
Anderson
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Meyer
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D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D011817:Rabbits; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D016222:Fibroblast Growth Factor 2