Effect of high-lipid high-nitrogen intravenous nutrition on total body nitrogen, visceral protein synthesis and nitrogen balance.
The impact of high-lipid intravenous nutrition (IVN) on selected indices of nitrogen retention following major surgical resection was studied. Twenty-two patients, randomly allocated to two equal well matched groups, received either high-lipid IVN (75 per cent non-protein calories supplied as lipid) or isocaloric isonitrogenous glucose IVN (100 per cent non-protein calories supplied as glucose). Total body nitrogen (assessed by in vivo neutron activation analysis), nitrogen balance and levels of circulating proteins were measured. Mean(s.d.) total body nitrogen and fat-free mass decreased (P = 0.04) in patients receiving high-lipid IVN, -109(36) gN and -1.7(0.4) kg respectively, but not in those given glucose-only IVN, 8(43) gN and 0.1(1.0) kg. This small loss of body protein does not appear to be clinically significant because postoperative hospital stay, complication rates and the acute-phase protein response (immunological and visceral) were similar in the two groups.
Kohlhardt
S R
SR
University of Sydney Department of Surgery, Royal North Shore Hospital of Sydney, St Leonards, Australia.
Smith
R C
RC
Rose
A
A
Allen
B
B
D001823:Body Composition; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000008:administration & dosage / Q000378:metabolism*; D010288:Parenteral Nutrition; D011182:Postoperative Care; D014176:Protein Biosynthesis; D014781:Viscera / Q000378:metabolism
D008055:Lipids; D009584:Nitrogen