title: Cholestatic jaundice induced by spontaneous disruption of an oestrogen implant.
abstract: OBJECTIVE
  To describe the case of a women with cholestatic jaundice induced by the spontaneous fragmentation of an oestrogen implant.
  
  
  METHODS
  A 48-year-old woman, who presented with jaundice, pruritus and a flu-like illness 2 weeks after the insertion of a 100 mg oestradiol implant into her right buttock.
  
  
  METHODS
  At presentation the implant was removed and found to be fragmented. Investigations revealed an oestradiol level of 1548 pmol/l and an oestrogen-induced cholestatic jaundice.
  
  
  RESULTS
  After removal of the implant and progesterone therapy, the patients symptoms resolved.
  
  
  CONCLUSIONS
  This is the first reported case of cholestatic jaundice induced by a subcutaneous oestrogen implant.
authors.affiliation: Department of Gastroenterology, Central Middlesex Hospital, London, UK.
authors.forename: T E
authors.initials: TE
authors.lastname: Bowling
authors.forename: M
authors.initials: M
authors.lastname: al-Adnani
authors.forename: D B
authors.initials: DB
authors.lastname: Silk
mesh_terms: D002779:Cholestasis / Q000139:chemically induced*; D004343:Drug Implants / Q000009:adverse effects; D004868:Equipment Failure; D004958:Estradiol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D004343:Drug Implants; D004958:Estradiol