title: Increased fearfulness of Fyn tyrosine kinase deficient mice.
abstract: Fyn-deficient mice were produced by inserting the beta-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.
authors.affiliation: Department of Psychology, Faculty of Letters, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyakawa
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Niki
mesh_terms: D000818:Animals; D001483:Base Sequence; D005106:Exploratory Behavior / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D008027:Light; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D011505:Protein-Tyrosine Kinases / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D051076:Proto-Oncogene Proteins c-fyn
chemical_list: D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn