title: Renal function in gout patients.
abstract: Patients with gouty arthritis were examined at Veterans General Hospital to evaluate whether their renal function is impaired and to define the factor(s), if any, of renal function deterioration. A total of 152 cases were included in the study, and the patients were divided into two groups. One group (n = 80) exhibited pure gout without any associated medical problems or preexisting renal disorders. The second group (n = 72) included patients with gout and hypertension. The group with pure gout was further stratified into patients with tophi (n = 21) and those without (n = 59). Seventy-two sex- and age-matched normal adults served as the control group. We found (1) that the renal function was impaired in the pure-gout group when compared with sex- and age-matched normal individuals (serum creatinine 1.56 +/- 0.64 vs. 0.90 +/- 0.16 mg/dl, p = 0.0001; creatinine clearance 59.91 +/- 30.90 vs. 97.10 +/- 27.19 ml/min, p = 0.0001); (2) that the renal function was significantly more aggravated in patients with clinically visible tophi than in those without (gout with tophi vs. gout without tophi: serum creatinine 1.89 +/- 0.90 vs. 1.44 +/- 0.48 mg/dl, p = 0.040; creatinine clearance 47.27 +/- 31.90 vs. 64.40 +/- 29.53 ml/min, p = 0.030), and (3) that a further significant decline of the renal function was noted in gouty patients with an associated medical illness, i.e., hypertension (gout with hypertension vs. pure gout: serum creatinine 2.10 +/- 0.97 vs. 1.56 +/- 0.64 mg/dl, p = 0.0001; creatinine clearance 45.06 +/- 24.69 vs. 59.91 +/- 30.90 ml/min, p = 0.0029).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Nephrology, Veterans General Hospital, Taipei, Taiwan, ROC.
authors.forename: D C
authors.initials: DC
authors.lastname: Tarng
authors.forename: H Y
authors.initials: HY
authors.lastname: Lin
authors.forename: M L
authors.initials: ML
authors.lastname: Shyong
authors.forename: J S
authors.initials: JS
authors.lastname: Wang
authors.forename: W C
authors.initials: WC
authors.lastname: Yang
authors.forename: T P
authors.initials: TP
authors.lastname: Huang
mesh_terms: D015210:Arthritis, Gouty / Q000150:complications / Q000503:physiopathology*; D001706:Biopsy; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D014527:Uric Acid / Q000032:analysis
chemical_list: D014527:Uric Acid