title: Twin children in The Gambia: evidence for genetic regulation of physical characteristics in the presence of sub-optimal nutrition.
abstract: It has been demonstrated that physical growth characteristics are subject to genetic regulation. However, in developing countries, environmental factors such as food availability and frequent infections are associated with growth faltering which is particularly marked in infancy. We have conducted anthropometric measurements of a cohort of twin children aged less than 14 years living in a rural area of The Gambia to ascertain the extent to which genetic factors influence physical growth in the presence of a sub-optimal diet. Almost 25% of the children were more than 2SD below the median of the reference population in terms of their height-for-age Z score, indicating a marked level of undernutrition. Nevertheless, the within-pair variances were significantly less for monozygous than for dizygous twin pairs for the following variables: height, head circumference and body mass index (p < 0.01); weight (p < 0.02) and mid upper arm circumference (p < 0.1), indicating that there is a strong genetic influence on growth regulation despite the sub-optimal nutrition.
authors.affiliation: Medical Research Council Laboratories, Fajara, The Gambia, West Africa.
authors.forename: A
authors.initials: A
authors.lastname: Jepson
authors.forename: W
authors.initials: W
authors.lastname: Banya
authors.forename: M
authors.initials: M
authors.lastname: Hassan-King
authors.forename: F
authors.initials: F
authors.lastname: Sisay
authors.forename: S
authors.initials: S
authors.lastname: Bennett
authors.forename: H
authors.initials: H
authors.lastname: Whittle
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D002648:Child; D015362:Child Nutrition Disorders / Q000150:complications* / Q000175:diagnosis; D004200:Diseases in Twins / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005714:Gambia; D006130:Growth Disorders / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D009749:Nutrition Surveys; D012307:Risk Factors