Gastric and duodenal anti-ulcer activity of sulpiride, a dopamine D2 receptor antagonist, in rats.
The gastric and duodenal anti-ulcer activity of sulpiride, a dopamine D2 receptor antagonist, was studied on various types of experimentally induced ulcers in rats, viz., pylorus ligation and water immersion + restraint stress-induced gastric ulcers, gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs and reserpine, and duodenal ulcers induced by cysteamine hydrochloride. It has been found to possess significant anti-ulcer activity against all these models. In 19 h pylorus ligated rats, it significantly reduced the gastric secretion, increased the fucose and sialic acid concentration of the gastric juice and reduced its protein content, thus increasing the total carbohydrate:protein (TC/PR) ratio. These results suggest that the antisecretory and gastric mucosal barrier strengthening effects of sulpiride may be responsible for its anti-ulcer activity. A central component also appears to be involved in its anti-ulcer action against water immersion + restraint stress model. The results of this study provide a rationale for its beneficial effect seen in the therapy of peptic ulcer disease.
Desai
J K
JK
Department of Pharmacology, B.V. Patel Pharmaceutical Education, Research & Development Centre, Ahmedabad, India.
Parmar
N S
NS
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D065127:Dopamine D2 Receptor Antagonists; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D007101:Immersion; D008297:Male; D011506:Proteins / Q000378:metabolism; D011708:Pylorus / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications; D013469:Sulpiride / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D065127:Dopamine D2 Receptor Antagonists; D011506:Proteins; D013469:Sulpiride