title: Prostaglandins and sex steroids from corpora lutea of pregnant mares. In vitro studies.
abstract: To delineate endocrine mechanisms regulating equine luteal function and the possible functional differences between one month and three month corpora lutea of pregnancy (CL), the in vitro basal releases of prostaglandin F (PGF), prostaglandin E2 (PGE2), progesterone, and 17 beta-estradiol by one and three month CL of pregnant mares were evaluated. In addition, the in vitro effects of PGF2 alpha PGE2, progesterone and 17 beta-estradiol on synthesis of prostaglandins (PGs) and sex steroids were studied. PGF, PGE2, and 17 beta-estradiol secretion was higher in one month than in three month CL, while progesterone was secreted similarly by both types of CL. PGE2 treatment decreased 17 beta-estradiol in one month CL; progesterone increased PGE2 in one and three month CL; 17 beta-estradiol increased PGE2 in one month CL. This study suggests that, in one month CL, PGE2 production could be regulated by progesterone and 17 beta-estradiol, while, in three month CL, this prostaglandin seems to be under the control of progesterone alone.
authors.affiliation: Department of Molecular, Cellular and Animal Biology, University of Camerino, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gobbetti
authors.forename: M
authors.initials: M
authors.lastname: Zerani
authors.forename: F
authors.initials: F
authors.lastname: Vannucci
authors.forename: R
authors.initials: R
authors.lastname: Marini
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D005069:Evaluation Studies as Topic; D005260:Female; D006736:Horses / Q000502:physiology*; D066298:In Vitro Techniques; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*
chemical_list: D011460:Prostaglandins F; D011374:Progesterone; D004958:Estradiol; D015232:Dinoprostone