Colonic fermentation: metabolic and clinical implications.
Colonic SCFA formation from fermentable carbohydrate is important for the maintenance of morphologic and functional integrity of the colonic epithelium. Carbohydrate-induced diarrhea occurs when the amount of carbohydrate entering the colon exceeds its fermentation capacity. Deficient availability or utilization of SCFA, mainly of n-butyrate, is the cause of diversion colitis and may play important roles in colonic carcinogenesis, in starvation and enterotoxigenic diarrhea, and in idiopathic UC.
Soergel
K H
KH
Division of Gastroenterology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226.
D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D000693:Anaerobiosis; D000818:Animals; D002087:Butyrates / Q000378:metabolism*; D020148:Butyric Acid; D002455:Cell Division; D003093:Colitis, Ulcerative / Q000150:complications; D003106:Colon / Q000382:microbiology*; D003967:Diarrhea / Q000209:etiology / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005285:Fermentation; D005766:Gastrointestinal Contents / Q000382:microbiology*; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism; D008286:Malabsorption Syndromes / Q000150:complications; D011422:Propionates / Q000378:metabolism*; D012418:Ruminants / Q000378:metabolism; D013217:Starvation / Q000150:complications
D000085:Acetates; D002087:Butyrates; D004040:Dietary Carbohydrates; D011422:Propionates; D020148:Butyric Acid; D006859:Hydrogen; C029658:propionic acid; D019342:Acetic Acid