title: Cytogenetic and FISH investigations on tetrasomy 8 in ANLL.
abstract: Two patients with "de novo" ANLL and tetrasomy of chromosome 8 at diagnosis are described. A mosaic karyotype with coexistence of normal metaphases was found in both cases. Trisomy 8 was also present in one metaphase of the first patient. Fluorescent in situ hybridization with a centromeric probe from chromosome 8 was applied in the second case, confirming the presence of a minor population with trisomy 8 in interphase nuclei.
authors.affiliation: Ematologia e Immunologia Clinica, Università degli Studi di Perugia, Policlinico Monteluce, Italy.
authors.forename: R
authors.initials: R
authors.lastname: La Starza
authors.forename: B
authors.initials: B
authors.lastname: Crescenzi
authors.forename: C
authors.initials: C
authors.lastname: Matteucci
authors.forename: M F
authors.initials: MF
authors.lastname: Martelli
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male