Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal.
Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated expression and function of myogenic transcription factors ensures that proliferation and differentiation of skeletal muscle cells are mutually exclusive processes.
Lassar
A B
AB
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Skapek
S X
SX
Novitch
B
B
D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D018257:Helix-Loop-Helix Motifs / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology*; D017570:MyoD Protein / Q000502:physiology; D015513:Oncogene Proteins / Q000502:physiology; D012208:Rhabdomyosarcoma
D017570:MyoD Protein; D015513:Oncogene Proteins