title: Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines.
abstract: The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.
authors.affiliation: Eijkman-Winkler Institute of Medical Microbiology, Utrecht University, The Netherlands.
authors.forename: E A
authors.initials: EA
authors.lastname: DeVelasco
authors.forename: H A
authors.initials: HA
authors.lastname: Dekker
authors.forename: P
authors.initials: P
authors.lastname: Antal
authors.forename: K P
authors.initials: KP
authors.lastname: Jalink
authors.forename: J A
authors.initials: JA
authors.lastname: van Strijp
authors.forename: A F
authors.initials: AF
authors.lastname: Verheul
authors.forename: J
authors.initials: J
authors.lastname: Verhoef
authors.forename: H
authors.initials: H
authors.lastname: Snippe
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002460:Cell Line; D007106:Immune Sera / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009895:Opsonin Proteins / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D011134:Polysaccharides / Q000276:immunology; D062605:Quillaja Saponins; D012503:Saponins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D007106:Immune Sera; D009895:Opsonin Proteins; D011134:Polysaccharides; D062605:Quillaja Saponins; D012503:Saponins; C046386:Quil A