The analysis of virus-caused alterations of cellular and humoral immunoresponsiveness during the first days of morbilli rush in the young adult population.
The parameters of cellular and humoral immune responsiveness were studied during the first days of morbilli rush in the group of 34 young adult patients. The analysis of cell-mediated immune response included T cell relative and absolute numbers, mitogen-induced T cell proliferative response, as well as the relative and absolute numbers of mononuclear phagocytes. The tested parameters of humoral immune response included B cell relative and absolute numbers, serum concentrations of immunoglobulins IgG, IgA and IgM, and serum level of immune complexes (IC). The reduction of total leukocyte number, T cell and B cell relative and absolute numbers, as well as diminished mitogen-induced T cell proliferative response, associated with the elevation of IgM and IC serum levels were found in the majority of analyzed patients. Moreover, the subsequent analysis revealed positive correlations between T cell percentage and T cell proliferative response, as well as between serum concentrations of IgM and IC. These data confirmed the presence of acute morbilli infection-caused disturbances of patients' immunocompetence.
Draca
S
S
Department of Clinical and Experimental Oncology, Institute of Oncology and Radiology of Serbia, Belgrade, Yugoslavia.
Zerjav
S
S
Radivojević
M
M
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000097:blood; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D018185:Morbillivirus Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M