Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere.
Vazquez
M L
ML
Searle Discovery Research, Skokie, Illinois 60077.
Bryant
M L
ML
Clare
M
M
DeCrescenzo
G A
GA
Doherty
E M
EM
Freskos
J N
JN
Getman
D P
DP
Houseman
K A
KA
Julien
J A
JA
Kocan
G P
GP
D002460:Cell Line; D018360:Crystallography, X-Ray; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology
D017320:HIV Protease Inhibitors; D013449:Sulfonamides