Endocrine profiles in six patients with acanthosis nigricans.
Six women (age range 17-38 years), who presented to the dermatology services with biopsy-proven acanthosis nigricans of variable duration were evaluated to rule out endocrine diseases. Menstrual abnormalities (5/6 patients), pallid striae (4/6 patients), hirsutism (4/6 patients) and acne vulgaris (2/6 patients) were found on physical examination. All the patients had body mass indices in the obese (> 27 kg/m2) range, and in association we found ovarian hyperthecosis, PCOD, premature ovarian failure, glucose intolerance and hyperprolactinaemia in the above six patients. The importance of appropriate endocrinal evaluation in patients with biopsy-proven acanthosis nigricans is emphasized.
Kapasi
A
A
Department of Dermatology, TN Medical College & B Y L Nair Charitable Hospital, Bombay.
Varthakavi
P K
PK
Khopkar
U
U
Wadhwa
S L
SL
Nihalani
K D
KD
D000052:Acanthosis Nigricans / Q000175:diagnosis* / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D004700:Endocrine System Diseases / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D012867:Skin / Q000473:pathology