Enhanced expression of catalytic subunit isoform PP1 gamma 1 of protein phosphatase type 1 associated with malignancy of osteogenic tumor.
The expressions of the three catalytic subunits of protein phosphatase (PP) type 1 and 2A, PP1 alpha, PP1 gamma 1, and PP2AC, were examined in 14 cases of three types of osteogenic tumor using immunohistochemical analysis. The percentage of tumor cells stained positively with antiserum against PP1 catalytic subunit-isoform PP1 gamma 1 was significantly higher in malignant osteogenic tumors than in benign osteogenic tumors. Furthermore, malignant osteogenic tumor showed markedly high S-phase fraction in the cell cycle of tumor cells, as compared to benign osteogenic tumors. These results suggest that PP1 gamma 1 is involved in the accelerated growth of malignant cells in osteogenic tumors.
Sogawa
K
K
Department of Pathology, Kagawa Medical School, Japan.
Yamada
T
T
Oka
S
S
Kawasaki
K
K
Mori
S
S
Tanaka
H
H
Norimatsu
H
H
Cai
Y
Y
Kuwabara
H
H
Shima
H
H
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000201:enzymology* / Q000473:pathology; D002384:Catalysis; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002813:Chondrosarcoma / Q000201:enzymology* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis*; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000201:enzymology* / Q000473:pathology; D010749:Phosphoprotein Phosphatases / Q000032:analysis*; D016196:S Phase / Q000502:physiology
D007527:Isoenzymes; D046911:Macromolecular Substances; D010749:Phosphoprotein Phosphatases