Changes in self-stimulation response during chronic morphine treatment and after withdrawal of morphine in rats.
Morphine (5-20 mg/kg, s.c.) dose-dependently inhibited the hypothalamic self-stimulation response 1-2 hr after administration of the drug. Thereafter, slight increase in the self-stimulation response was seen 4-8 hr after drug administration. The depressant effect induced by 10 mg/kg, s.c. of morphine on the self-stimulation response was antagonized by 1 mg/kg, s.c. of levallorphan. Repeated administration of morphine (10 mg/kg, s.c.) resulted in an increase of the self-stimulation response. The self-stimulation response rate was increased significantly 24 and 48 hr after withdrawal of morphine in chronic-morphine-treated rats; In these rats, the initial dose of morphine (10 mg/kg, injected s.c. twice daily 7 days a week) was increased gradually until at the end of 5 weeks, each dose was 50 mg/kg, s.c.
Kamei
C
C
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000502:physiology; D007977:Levallorphan / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009021:Morphine Dependence / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D012653:Self Stimulation / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000523:psychology*
D007977:Levallorphan; D009020:Morphine