title: Regulation of translation and cell growth by eIF-4E.
abstract: This review discusses the regulation of a key controlling step in the initiation of protein synthesis, the binding of mRNA to ribosomes. Particular focus is given to the phosphorylation of the cap-binding factor, eIF-4E, and the role of this factor in the regulation of cell growth.
authors.affiliation: Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Sonenberg
mesh_terms: D000818:Animals; D002455:Cell Division / Q000235:genetics*; D039561:Eukaryotic Initiation Factor-4E; D006801:Humans; D010448:Peptide Initiation Factors / Q000502:physiology*; D014176:Protein Biosynthesis
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D010448:Peptide Initiation Factors