Effect of dizocilpine (MK-801) on the catalepsy induced by delta 9-tetrahydrocannabinol in mice.
Mice treated with delta 9-tetrahydrocannabinol (THC; 5 and 10 mg/kg i.v.) showed the catalepsy in high bar test, and median descent latencies of catalepsy were about 150 sec. Dizocilpine (MK-801, 0.05 and 0.1 mg/kg), non-competitive N-methyl-D-aspartate (NMDA) antagonist, significantly attenuated THC-induced catalepsy. Furthermore, the anticataleptic effect of MK-801 on THC-induced catalepsy was blocked by acetylcholine agonist oxotremorine (0.005 mg/kg) and dopamine antagonist haloperidol (0.01 mg/kg), but not by NMDA. Oxotremorine, haloperidol, and NMDA themselves did not affect THC-induced catalepsy at the doses used. These results suggest that the anticataleptic effect of MK-801 on THC-induced catalepsy may be developed through dopaminergic and acetylcholinergic neuronal systems.
Kinoshita
H
H
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Hasegawa
T
T
Katsumata
Y
Y
Kameyama
T
T
Yamamoto
I
I
Nabeshima
T
T
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D004298:Dopamine / Q000502:physiology; D013759:Dronabinol / Q000633:toxicity*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D010095:Oxotremorine / Q000494:pharmacology; D010300:Parkinson Disease; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate; D010095:Oxotremorine; D016291:Dizocilpine Maleate; D013759:Dronabinol; D006220:Haloperidol; D000109:Acetylcholine; D004298:Dopamine