Rapamycin (Sirolimus) inhibits vascular smooth muscle DNA synthesis in vitro and suppresses narrowing in arterial allografts and in balloon-injured carotid arteries: evidence that rapamycin antagonizes growth factor action on immune and nonimmune cells.
Morris
R E
RE
Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA 94305-5247.
Cao
W
W
Huang
X
X
Gregory
C R
CR
Billingham
M E
ME
Rowan
R
R
Shorthouse
R A
RA
D000800:Angioplasty, Balloon / Q000009:adverse effects; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology* / Q000637:transplantation*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology* / Q000637:transplantation; D009173:Mycophenolic Acid / Q000494:pharmacology; D011090:Polyenes / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D020123:Sirolimus
D007166:Immunosuppressive Agents; D011090:Polyenes; D016572:Cyclosporine; D004247:DNA; D009173:Mycophenolic Acid; D020123:Sirolimus