title: [Arteriosclerosis of the thoracic aorta as a source of systemic emboli. A clinico-pathologic study].
abstract: The significance of the thoracic aorta as a source of systemic emboli in addition to other sources of embolism remains unexplained. A study of 120 consecutive necropsies (65 men, 55 women; mean age 71 [29-94] years) analysed the possible correlation of the severity of arteriosclerosis of the aorta, the carotid arteries and the arteries at the base of the brain as well as cardiac changes, with potential sources of emboli and with proven emboli (n = 39). Complex and fibrous plaques in the arch of the aorta, ipsilateral carotid artery stenoses, a history of atrial fibrillation and heart weight correlated significantly with emboli on both uni- and multivariant analysis. But the presence of calcified and complex plaques in the descending aorta, as well as moderate and severe arteriosclerosis in the arteries at the base of the brain, correlated significantly only on univariant analysis. Ischaemic brain lesions had been clinically silent in twelve of 32 cases, while visceral emboli had been silent in nine out of ten cases. -It is concluded from these data that, in addition to the cardiac chambers and arteriosclerosis of the arteries at the base of the brain, advanced arteriosclerosis of the aortic arch is an important source of systemic emboli. As many of the emboli remain silent, their incidence is probably underestimated clinically.
authors.affiliation: Klinik für Kardiologie, Medizinischen Universität Lübeck.
authors.forename: R
authors.initials: R
authors.lastname: Mitusch
authors.forename: M
authors.initials: M
authors.lastname: Khatibzadeh
authors.forename: B
authors.initials: B
authors.lastname: Gromoll
authors.forename: E
authors.initials: E
authors.lastname: Reusche
authors.forename: U
authors.initials: U
authors.lastname: Stierle
authors.forename: A
authors.initials: A
authors.lastname: Sheikhzadeh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000473:pathology*; D001158:Arteries / Q000473:pathology; D001161:Arteriosclerosis / Q000150:complications* / Q000473:pathology; D001921:Brain / Q000098:blood supply; D002339:Carotid Arteries / Q000473:pathology; D016893:Carotid Stenosis / Q000150:complications; D004617:Embolism / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
vernacular_title: Arteriosklerose der thorakalen Aorta als Quelle systemischer Embolien. Eine klinisch-pathologische Studie.