Circulating growth hormone binding proteins.
The 'high-affinity' growth hormone binding protein (GHBP) corresponds to the extracellular domain of the membrane-associated GH receptor. In man, it is produced by proteolytic cleavage of the extracellular portion of the receptor, while in the rat and mouse, it is the product of alternative splicing of GH receptor mRNA. Because of the relationship between the GHBP and the GH receptor, measurement of serum concentrations of GHBP provide an index of GH receptor concentrations and/or affinity.
Rosenfeld
R G
RG
Department of Pediatrics, Doernbecher Memorial Hospital for Children, Oregon Health Sciences University, Portland 97201.
D000328:Adult; D000818:Animals; D002352:Carrier Proteins / Q000032:analysis / Q000097:blood* / Q000235:genetics; D002648:Child; D004351:Drug Resistance; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D051379:Mice; D011247:Pregnancy; D051381:Rats; D013577:Syndrome
D002352:Carrier Proteins; D013006:Growth Hormone; C051815:somatotropin-binding protein