Cystinosis and gingival hyperplasia: demonstration of cystine crystals in gingival tissue and unusual aspects of management.
A patient with nephropathic cystinosis developed gingival hyperplasia secondary to cyclosporine-A therapy for his renal allograft. The typical crystals described on electron microscopic examination of other organs of patients with cystinosis were seen in the resected gingiva of this patient. These crystals have not been previously described in this location. Unusual aspects of the management of this patient are discussed.
Heller
A N
AN
Department of Dentistry, Beth Israel Medical Center, NY.
Heller
D S
DS
Schwimmer
A
A
Gordon
R E
RE
Cambria
R J
RJ
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003460:Crystallization; D016572:Cyclosporine / Q000009:adverse effects; D003545:Cysteine / Q000032:analysis; D003554:Cystinosis / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D017742:Dental Care for Chronically Ill; D005882:Gingival Diseases / Q000378:metabolism* / Q000473:pathology; D005885:Gingival Hyperplasia / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D011292:Premedication
D000900:Anti-Bacterial Agents; D016572:Cyclosporine; D003545:Cysteine