title: [Hyperinsulinemia in women with hyperandrogenemia].
abstract: In the peripheral blood serum from 24 females with hyperandrogenemia and 12 controls we determined concentrations of total testosterone (T), dehydroepiandrosterone-sulfate (DHEA-S), sex hormone binding globulin (SHBG) and insulin, and calculated Free Androgen Index. In hyperandrogenemic patients we found significantly higher mean concentrations of total testosterone when compared to the controls (n = 192; 3.5 + 1.9 vs n = 76; 1.9 = 0.9; P < 0.001), insulin (n = 95; 23.2 = 15.1; vs n = 33; 9.9 = 4.8; p < 0.001) DHEA-S (n = 70; 6.2 = 1.6 vs n = 27; 3.6 = 1.9; p < 0.001), FAI (n = 65; 27 = 32.9 vs n = 33; 3.9 = 2.1; p < 0.001) while the levels of SHBG in hyperandrogenemics were significantly lower than in the controls (n = 67; 24.6 = 15.9 vs n = 33; 52.8 = 19.3; p < 0.001). We found a positive correlation between the relative body mass and insulin concentrations (r = 0.67) in the form of the repeated sampling mean values; between the relative body mass and the mean values of the total testosterone concentrations (r = 0.42) and between the total testosterone concentrations and insulin (r = 0.32).
authors.affiliation: Opsta bolnica, Medicinski centar Zrenjanin.
authors.forename: B
authors.initials: B
authors.lastname: Nedeljković
authors.forename: V
authors.initials: V
authors.lastname: Kmezić-Slavić
authors.forename: J
authors.initials: J
authors.lastname: Sekulić
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications; D007247:Infertility, Female / Q000097:blood; D007328:Insulin / Q000097:blood*
chemical_list: D000728:Androgens; D007328:Insulin
vernacular_title: Hiperinsulinemija u zena sa hiperandrogenemijom.