The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries.
A series of peptides identified through the use of synthetic hexapeptide combinatorial libraries (represented by the formula Ac-RRWWCO-NH2) were examined for their antimicrobial activity against five different micro-organisms. Their toxicity was also evaluated in an in vitro haemolytic assay. The peptides showed activity against the five micro-organisms, although higher activities were found against Gram-positive bacteria. Both growth inhibition and cell viability assays were carried out to demonstrate the bactericidal activities of these peptides against two of the micro-organisms tested. The dimeric cystine forms of these peptides were shown to have biological activities identical to the monomeric forms.
Blondelle
S E
SE
Torrey Pines Institute for Molecular Studies, San Diego, CA 92121.
Takahashi
E
E
Dinh
K T
KT
Houghten
R A
RA
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D006461:Hemolysis; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D010084:Oxidation-Reduction
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009842:Oligopeptides