title: A useful diagnostic method for drug-induced pneumonitis: a case report.
abstract: A 51 year-old male was admitted to our hospital with chief complaints of fever, dry cough and dyspnea. Chest X-ray films and his history of taking Chinese medicine for liver dysfunction were suggestive of drug-induced pneumonitis. Lymphocyte stimulation test (LST) to causative Chinese medical drugs of Sho-saiko-to and Dai-saiko-to was negative with peripheral blood lymphocytes (PBL), but was positive with lymphocytes from bronchoalveolar lavage fluid (BALF). In vivo challenge test for Sho-saiko-to was positive. The LST with BALF-lymphocytes proved to be very useful in making a diagnosis of drug-induced pneumonitis.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kawasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Mizushima
authors.forename: H
authors.initials: H
authors.lastname: Kunitani
authors.forename: M
authors.initials: M
authors.lastname: Kitagawa
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D001992:Bronchoalveolar Lavage Fluid; D004365:Drugs, Chinese Herbal / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000175:diagnosis*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
chemical_list: D004365:Drugs, Chinese Herbal; C018142:saiko-keishi-to