[Effects of methylprednisolone on functional recovery of stunned myocardium in dogs].
We investigated the effects of methylprednisolone (MP) on the time course of functional recovery of myocardium following 15 min of coronary artery occlusion and 1 h reperfusion (stunned myocardium) in morphine-urethane-alpha-chloralose-anesthetized dogs. Myocardial segmental shortening (%SS) in the subendocardium of ischemic areas was measured by sonomicrometry. MP (30 mg.kg-1 iv) was administrated 90 min before the occlusion period. Compared with the control group, %SS in the ischemic region was significantly (P < 0.05) greater in the MP-treated group during 15 to 60 min of the reperfusion period. There were no significant differences in other hemodynamic data between the control and MP-treated groups. In conclusion, it was shown that MP enhances the functional recovery of stunned myocardium.
Nakayama
M
M
Department of Anesthesiology, Sapporo Medical University, School of Medicine.
Fujita
S
S
Kanaya
N
N
Tuchida
H
H
Namiki
A
A
D000818:Animals; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D009200:Myocardial Contraction; D017682:Myocardial Stunning / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
D008775:Methylprednisolone