Biocompatibility of a heparin-bonded membrane oxygenator (Carmeda MAXIMA) during the first 90 minutes of cardiopulmonary bypass: clinical comparison with the conventional system.
We clinically compared a heparin-bonded Carmeda MAXIMA membrane oxygenator to a nonheparin-bonded MAXIMA in 20 patients undergoing coronary artery bypass grafting or valve replacement. Reductions of fibrinogen, factor XII, and high molecular weight kininogen were greater in the MAXIMA group. Serum C3a and free hemoglobin were lower in the Carmeda group. The level of C4a, though remarkably lower than that of C3a, was higher in the Carmeda group then in the MAXIMA group. Both oxygenators performed well in terms of blood gas exchange. We conclude that the heparin-bonded Carmeda oxygenator offers superior biocompatibility during cardiopulmonary bypass.
Shigemitsu
O
O
Second Department of Surgery, Oita Medical University, Japan.
Hadama
T
T
Takasaki
H
H
Mori
Y
Y
Kimura
T
T
Miyamoto
S
S
Sako
H
H
Soeda
T
T
Kawawaki
Y
Y
Uchida
Y
Y
D001672:Biocompatible Materials; D002245:Carbon Dioxide / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000295:instrumentation / Q000379:methods; D015926:Complement C3a / Q000032:analysis; D015934:Complement C4a / Q000032:analysis; D001026:Coronary Artery Bypass; D005174:Factor XII / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005345:Fibrinopeptide B / Q000032:analysis; D006351:Heart Valves / Q000601:surgery; D006454:Hemoglobins / Q000032:analysis; D006493:Heparin / Q000737:chemistry; D006801:Humans; D007704:Kininogens / Q000097:blood; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D010978:Platelet Factor 4 / Q000032:analysis; D014914:Whole Blood Coagulation Time; D001620:beta-Thromboglobulin / Q000032:analysis
D001672:Biocompatible Materials; D006454:Hemoglobins; D007704:Kininogens; D001620:beta-Thromboglobulin; D002245:Carbon Dioxide; D005345:Fibrinopeptide B; D010978:Platelet Factor 4; D015926:Complement C3a; D015934:Complement C4a; D005174:Factor XII; D005340:Fibrinogen; D006493:Heparin; D010100:Oxygen