Loss of neurones after long-term adrenalectomy in the adult rat hippocampal formation.
The effects of long-term adrenalectomy (ADX) on hippocampal neurones were investigated 5 months after surgery in male Sprague-Dawley rats. Cells in Nissl-stained sections from ADX rats were counted and compared with those in sections from sham-operated rats. The ADX rats had a significantly reduced number of dentate granule cells. A novel finding was a significant reduction in the number of pyramidal cells in CA1, CA2, CA3 and CA4 regions of the hippocampus. Thus long-term adrenalectomy causes loss of dentate granule cells and pyramidal neurones of the hippocampus.
Adem
A
A
Department of Geriatric Medicine, Karolinska Institute, Huddinge Hospital, Sweden.
Islam
A
A
Bogdanovic
N
N
Carlström
K
K
Winblad
B
B
D000315:Adrenalectomy; D000818:Animals; D006624:Hippocampus / Q000166:cytology*; D008297:Male; D009410:Nerve Degeneration; D009474:Neurons / Q000166:cytology*; D011184:Postoperative Period; D017966:Pyramidal Cells / Q000166:cytology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors