title: Influence of ranitidine on the hypoglycaemic activity of glibenclamide and tolbutamide in rabbits.
abstract: The influence of ranitidine on the hypoglycaemic activity of glibenclamide and tolbutamide was studied in rabbits. Ranitidine treatment (15 mg/kg, po, twice daily for one week) enhanced the hypoglycaemic activity of glibenclamide (40 micrograms/kg, po) while it has not altered either the hypoglycaemic activity or pharmacokinetics of tolbutamide (40 mg/kg, po) in rabbits.
authors.affiliation: Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam.
authors.forename: Y S
authors.initials: YS
authors.lastname: Krishnaiah
authors.forename: S
authors.initials: S
authors.lastname: Satyanarayana
authors.forename: D
authors.initials: D
authors.lastname: Visweswaram
mesh_terms: D000818:Animals; D004347:Drug Interactions; D005905:Glyburide / Q000493:pharmacokinetics* / Q000494:pharmacology; D007003:Hypoglycemia / Q000139:chemically induced*; D011817:Rabbits; D011899:Ranitidine / Q000494:pharmacology*; D014044:Tolbutamide / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D011899:Ranitidine; D014044:Tolbutamide; D005905:Glyburide