title: A case of intracytoplasmic edema of follicular epithelial cells in rat thyroid.
abstract: Hydropic change of follicular epithelial cells in the thyroid was observed in a female Fischer 344 rat. Microscopically follicular epithelial cells were characterized by edematous swelling with weakly eosinophilic and homogeneous cytoplasm. The cytoplasm was negative for periodic acid-Schiff reaction, and thyroxine- and thyroglobulin-immunohistochemical reactions. Electron-microscopically, a small amount of amorphous substance was noted in remarkably dilated rough-surfaced endoplasmic reticulum (r-ER), and slight regressive changes of cytoplasmic organella were also observed. These morphological changes may indicate that focal intracytoplasmic edema was occurred in r-ER, and that the change belonged to hydropic degeneration of the thyroid follicular cells in the thyroid.
authors.affiliation: Laboratory Animal Science, Sankyo Co., Ltd., Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takaoka
authors.forename: T
authors.initials: T
authors.lastname: Yamoto
authors.forename: M
authors.initials: M
authors.lastname: Teranishi
authors.forename: S
authors.initials: S
authors.lastname: Manabe
authors.forename: N
authors.initials: N
authors.lastname: Goto
mesh_terms: D000818:Animals; D001284:Atrophy; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000473:pathology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004487:Edema / Q000473:pathology / Q000662:veterinary*; D004721:Endoplasmic Reticulum / Q000473:pathology / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology; D005260:Female; D006056:Golgi Apparatus / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D011916:Rats, Inbred F344; D012376:Rodent Diseases; D013959:Thyroid Diseases / Q000473:pathology / Q000662:veterinary*; D013961:Thyroid Gland / Q000473:pathology* / Q000648:ultrastructure