title: Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
abstract: OBJECTIVE
  Inadequate vitamin B6 status has been associated with altered neuropsychiatric function, possibly through its effect on the metabolism of neurotransmitters, including serotonin (5-HT). The present eighteen month longitudinal study evaluated the relationship between vitamin B6 status and psychological distress in HIV-1 infected individuals, controlling for the influence of negative life events, social support and coping style.
  
  
  METHODS
  Biochemical measurements of nutritional status, and dietary intake evaluations were obtained in HIV-1 seropositive homosexual men, (at baseline: CDC Stages II and III, n = 70; Stage IVA, IVC2 n = 18) at six month intervals. Alterations in nutrient status (e.g., vitamin B6 adequate to inadequate; inadequate to adequate), were compared with changes in psychological distress, measured by the Profile of Mood States, using a multiple regression analysis.
  
  
  RESULTS
  A significant decline in psychological distress was demonstrated with normalization of vitamin B6 status from inadequate to adequate status (p < 0.02). A decrease in psychological distress was also observed with increased tryptophan intake in subjects who were vitamin B6 adequate (p < 0.02).
  
  
  CONCLUSIONS
  Significant effects for the nutritional variables remained even when negative life event stressors, social support, and coping style were controlled, suggesting that vitamin B6 status may be an important co-factor in determining level of psychological distress over time in HIV-1 infected individuals.
authors.affiliation: Department of Epidemiology and Public Health, University of Miami School of Medicine, FL 33101.
authors.forename: G
authors.initials: G
authors.lastname: Shor-Posner
authors.forename: D
authors.initials: D
authors.lastname: Feaster
authors.forename: N T
authors.initials: NT
authors.lastname: Blaney
authors.forename: H
authors.initials: H
authors.lastname: Rocca
authors.forename: E
authors.initials: E
authors.lastname: Mantero-Atienza
authors.forename: J
authors.initials: J
authors.lastname: Szapocznik
authors.forename: C
authors.initials: C
authors.lastname: Eisdorfer
authors.forename: K
authors.initials: K
authors.lastname: Goodkin
authors.forename: M K
authors.initials: MK
authors.lastname: Baum
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000523:psychology*; D000223:Adaptation, Psychological; D000328:Adult; D015658:HIV Infections / Q000175:diagnosis / Q000523:psychology*; D015497:HIV-1; D018451:Homosexuality, Male / Q000523:psychology; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015596:Nutrition Assessment; D012944:Social Support; D026681:Vitamin B 6 Deficiency / Q000175:diagnosis / Q000523:psychology*