Synthesis and pharmacology of two new histamine receptor antagonists related to ranitidine.
Pyridyl and 1,6-dihydropyridyl ranitidine analogues 1 and 2 were obtained by applying an improved modification of ranitidine synthesis. Compound 1 shows a selective H2 antagonistic activity while compound 2 is a non-selective histamine antagonist.
Navarro
J J
JJ
Departamento de Química Orgánica, Facultad de Quimicas, Salamanca, Spain.
Almeida
J F
JF
Anaya
J
J
Moran
J R
JR
Grande
M
M
Caballero
M C
MC
Palacios
B
B
Montero
M J
MJ
San Roman
L
L
D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011899:Ranitidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; C092458:N-(2-(((5-(dimethylaminomethyl)-2-furanyl)methyl)thio)ethyl)-(3-nitro-1,6-dihydropyridin-2-yl)amine; C092459:N-(2-((5-((dimethylamino)methyl)-2-furanyl)methylthio)ethyl)-(3-nitropyridin-2-yl)amine; D011899:Ranitidine