Early helper T-cell dysfunction in simian immunodeficiency virus but not in human immunodeficiency virus type-2-infected macaques.
Both naive and vaccinated macaques acquired a virus-specific proliferative helper T-cell reactivity in response to infection with the nonpathogenic human immunodeficiency virus type 2 (HIV-2). In contrast, macaques infected with the pathogenic simian immunodeficiency virus of the macaque strain (SIVmac) did not develop a helper T-cell response. Furthermore, a vaccine-induced preexisting T-cell reactivity was abrogated after SIVmac infection in vaccine failures. These differences may reflect the different pathogenicity of the two closely related viruses.
Dittmer
U
U
Deutsches Primatenzentrum, Abteilung Virologie und Immunologie, Göttingen, Germany.
Lüke
W
W
Stahl-Hennig
C
C
Coulibaly
C
C
Petry
H
H
Bodemer
W
W
Hunsmann
G
G
Voss
G
G
D016915:AIDS Vaccines / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015498:HIV-2 / Q000276:immunology*; D016130:Immunophenotyping; D008213:Lymphocyte Activation; D008252:Macaca fascicularis; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D013997:Time Factors; D014765:Viral Vaccines / Q000276:immunology*
D016915:AIDS Vaccines; D014765:Viral Vaccines