Effect of switching carbamazepine to oxcarbazepine on the plasma levels of neuroleptics. A case report.
Carbamazepine was switched to its 10-keto analogue oxcarbazepine among six difficult-to-treat schizophrenic or organic psychotic patients using concomitantly haloperidol, chlorpromazine or clozapine. This change resulted within 2-4 weeks in the 50-200% increase in the plasma levels of these neuroleptics and the appearance of extrapyramidal symptoms. None of the patients showed any clinical deteriotation during the following 3-6 months. The results of this case report support the idea that in contrast with carbamazepine oxcarbazepine does not induce the hepatic microsomal enzyme systems regulating the inactivation of antipsychotic drugs.
Raitasuo
V
V
Kellokoski Hospital, Finland.
Lehtovaara
R
R
Huttunen
M O
MO
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D000078330:Oxcarbazepine; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D002220:Carbamazepine; D000078330:Oxcarbazepine