The effect of interferon on activated peripheral blood T lymphocytes in patients with chronic active hepatitis B.
The effect of interferon-alpha 2b treatment on activated T lymphocytes -T cells expressing interleukin-2 receptors-(IL-2R) was studied in 18 patients with chronic active hepatitis B. Blood samples were taken before, on the 2nd, 4th and 6th month of treatment. Patients were divided in 3 groups according to their response to therapy (complete, partial, no response). At the end of treatment, IL-2R+ cells were decreased in the group of patients with complete response, unchanged in patients with partial response and increased in patients with no response. These results confirm the immunomodulatory effect of interferon and reflect the effect of treatment in the management of the disease.
Raptopoulou-Gigi
M
M
2nd Medical Department, Aristotelian University, Thessaloniki, Greece.
Orphanou-Koumerkeridou
H
H
D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy* / Q000276:immunology; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000187:drug effects*; D011994:Recombinant Proteins; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins