Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.
Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000:1.
Yamaoka
L H
LH
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Westbrook
C A
CA
Speer
M C
MC
Gilchrist
J M
JM
Jabs
E W
EW
Schweins
E G
EG
Stajich
J M
JM
Gaskell
P C
PC
Roses
A D
AD
Pericak-Vance
M A
MA
D002874:Chromosome Mapping; D004276:DNA, Satellite / Q000032:analysis*; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D009136:Muscular Dystrophies / Q000235:genetics*; D011110:Polymorphism, Genetic
D004276:DNA, Satellite