[T3, T4 and TSH serum levels in patients on long-term treatment for epilepsy].
The serum T3, T4 and TSH concentrations were assessed by RIA method in 25 (14 females, 11 males) long-term treated (mean treatment duration 12.8 years) epileptic patients. The mean serum T3, T4 and TSH levels were lower than in control group according to clinical picture of epilepsy and treatment applied. The lowest mean serum TSH concentration was in patients with known aetiology of epilepsy. Patients with tonic-clonic seizures had lower serum levels of all hormones measured in comparison with the patients with partial seizures. Mean serum T3, T4 and TSH levels were low in patient group receiving valproic acid. The lowest mean TSH serum concentration as compared to control group was in the patients treated with phenytoin. None of the epileptic patients developed clinical symptoms of hypothyreoidism.
Motta
E
E
II Katedry i Kliniki Neurologii SlAM, Zabrzu.
Rościszewska
D
D
Grzeszczak
W
W
Pokrzywnicki
W
W
Kapustecki
J
J
Kochańska
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use; D012720:Severity of Illness Index; D013972:Thyrotropin / Q000097:blood*; D014635:Valproic Acid / Q000627:therapeutic use
D014635:Valproic Acid; D010672:Phenytoin; D013972:Thyrotropin
Poziom T3, T4 I TSH w surowicy chorych długotrwale leczonych z powodu padaczki.