title: Pyloric channel ulcers: management and three-year follow-up.
abstract: Twenty-five patients with pyloric channel ulcers are presented. They were predominantly males (84%), with a mean age of 54 years. Four patients were operated upon in the initial admission because of gastric outlet obstruction in three and persistent bleeding in one. Twenty-one patients received H2-antagonist treatment (ranitidine 150 mg or cimetidine 400 mg twice a day). Clinical and endoscopic healing rates were 76% and 38% respectively at 6 weeks, and 91% and 85% respectively at 12 weeks of treatment. The recurrence rate at an average of 3 years of follow-up period on maintenance treatment (ranitidine 150 mg or cimetidine 400 mg nightly) was 65%. Three patients were operated upon during the follow-up period due to persistent symptoms in two and recurrence with obstruction in one Surgical procedures were vagotomy + drainage (five patients) and vagotomy + antrectomy (two patients). There were no recurrences in surgically treated patients at an average of 3.5 years of follow-up, and all were graded as Visick I or II.
authors.affiliation: Department of Surgery, National University of Singapore.
authors.forename: Y
authors.initials: Y
authors.lastname: Tekant
authors.forename: P
authors.initials: P
authors.lastname: Goh
authors.forename: C
authors.initials: C
authors.lastname: Low
authors.forename: S S
authors.initials: SS
authors.lastname: Ngoi
mesh_terms: D002927:Cimetidine / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000601:surgery; D011706:Pyloric Antrum; D011899:Ranitidine / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D002927:Cimetidine; D011899:Ranitidine