title: Administration of hepatitis A vaccine to a military population by needle and jet injector and with hepatitis B vaccine.
abstract: Military personnel are an important target population for hepatitis A immunization. Soldiers are often given vaccines by jet injector and may be required to receive multiple vaccines at one time. Formalin-inactivated hepatitis A vaccine containing 360 ELISA units of antigen was evaluated at Fort Campbell. Volunteers received vaccine at 0, 1, and 6 months as follows: group 1, hepatitis A vaccine by needle; group 2, hepatitis A vaccine by jet injector; group 3, hepatitis B vaccine by needle; and group 4, both hepatitis vaccines by needle in separate arms. Immune response and reactogenicity were evaluated. After two doses, recipients of vaccine administered by jet injector had a higher prevalence of antibody than those who received vaccine by needle (93% vs. 79%). By the 8th month, the vaccine was 100% immunogenic by either route or with hepatitis B vaccine. No interaction between hepatitis A and B vaccines was detected.
authors.affiliation: Walter Reed Army Institute of Research, Washington, DC.
authors.forename: C H
authors.initials: CH
authors.lastname: Hoke
authors.forename: J E
authors.initials: JE
authors.lastname: Egan
authors.forename: M H
authors.initials: MH
authors.lastname: Sjogren
authors.forename: J
authors.initials: J
authors.lastname: Sanchez
authors.forename: R F
authors.initials: RF
authors.lastname: DeFraites
authors.forename: P O
authors.initials: PO
authors.lastname: MacArthy
authors.forename: L N
authors.initials: LN
authors.lastname: Binn
authors.forename: R
authors.initials: R
authors.lastname: Rice
authors.forename: A
authors.initials: A
authors.lastname: Burke
authors.forename: J
authors.initials: J
authors.lastname: Hill
mesh_terms: D000328:Adult; D005260:Female; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007267:Injections; D007277:Injections, Jet; D007629:Kentucky; D008297:Male; D008889:Military Personnel; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines