Effects of clozapine on CSF homovanillic acid in spasmodic torticollis.
We studied the effect of the atypical neuroleptic clozapine (CLO) on homovanillic acid (HVA) in cerebrospinal fluid (CSF) in five patients with spasmocid torticollis. Lumbar puncture was performed before and on the seventh day of CLO treatment. Although an HVA elevation was to be expected because of the antidopaminergic action of CLO, statistical analysis failed to reveal any significant increase of HVA under CLO treatment. Thus significance of CSF HVA may be less important for the description of antidopaminergic action of neuroleptics than previously assumed.
Thiel
A
A
Department of Psychiatry, Georg-August-University, Göttingen, Federal Republic of Germany.
Dressler
D
D
Reimer
A
A
Rüther
E
E
D000328:Adult; D003024:Clozapine / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014103:Torticollis / Q000134:cerebrospinal fluid*
D003024:Clozapine; D006719:Homovanillic Acid