title: Effects of posture, hypotension and locally applied vasoconstriction on the middle ear microcirculation in anaesthetized humans.
abstract: Studies by laser-Doppler flowmetry of middle ear microcirculation changes induced by physical and chemical stimuli in the animal have only recently been made. This prospective study, performed in humans, was designed to compare the effects of a postural manoeuvre (headup tilt 30 degrees), hypotension and locally applied vasoconstriction on middle ear blood flow during anaesthesia. Circulatory changes provoked by a headup tilt of 30 degrees, and successive intravenous boluses of potent vasodilators, were compared with circulatory changes provoked by locally applied adrenaline, in ten healthy patients in good physical states undergoing middle ear surgical repair. Heart rate and direct arterial pressure were continuously recorded via a radial artery cannula. Middle ear blood flow was continuously recorded via a laser-Doppler probe placed on the promontorium cavi tympani. Metabolic parameters (partial pressure of O2 and CO2 in arterial blood, pH, arterial lactate concentrations) and arterial concentrations of propofol were measured just before and just after the experiment. Headup tilt did not modify heart rate, mean arterial pressure or middle ear blood flow. Vasodilators (nicardipine, nitroprusside, nitroglycerin) provoked a fall in arterial pressure (P < 0.0001, P < 0.0001, P < 0.019, respectively), but did not induce any significant variations in heart rate; variations occurred in middle ear blood flow (P > 0.05, not significant) which were different according to patients and agents. Locally applied adrenaline provoked a fall in the middle ear blood flow (P < 0.0012), with no effect on heart rate and arterial pressure. There were no significant changes in metabolic values, or propofol serum concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Service d'Anesthesie-Réanimation, Centre Hospitalo-Universitaire Lyon-Sud, Pierre-Bénite, France.
authors.forename: C S
authors.initials: CS
authors.lastname: Degoute
authors.forename: C
authors.initials: C
authors.lastname: Dubreuil
authors.forename: M J
authors.initials: MJ
authors.lastname: Ray
authors.forename: J
authors.initials: J
authors.lastname: Guitton
authors.forename: M
authors.initials: M
authors.lastname: Manchon
authors.forename: V
authors.initials: V
authors.lastname: Banssillon
authors.forename: J L
authors.initials: JL
authors.lastname: Saumet
mesh_terms: D000293:Adolescent; D000328:Adult; D000758:Anesthesia; D004432:Ear, Middle / Q000098:blood supply*; D005260:Female; D006339:Heart Rate; D006801:Humans; D007022:Hypotension / Q000503:physiopathology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation; D011187:Posture / Q000502:physiology*; D011446:Prospective Studies; D012039:Regional Blood Flow; D014661:Vasoconstriction