Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection.
From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.
Anzala
O A
OA
Department of Medical Microbiology, University of Nairobi, Kenya.
Nagelkerke
N J
NJ
Bwayo
J J
JJ
Holton
D
D
Moses
S
S
Ngugi
E N
EN
Ndinya-Achola
J O
JO
Plummer
F A
FA
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D015497:HIV-1; D006801:Humans; D011477:Sex Work