QSA 10 (idebenone) or probucol supplementation of organ preservation solutions prevents oxygen radical-mediated injury of hepatic microsomes.
Wieland
E
E
Department of Clinical Chemistry, Georg-August-Universität, Göttingen, Germany.
Schütz
E
E
Armstrong
V W
VW
Ringe
B
B
Oellerich
M
M
D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D016227:Benzoquinones / Q000494:pharmacology*; D015153:Blotting, Western; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione; D005982:Glutathione Transferase / Q000032:analysis / Q000378:metabolism; D007328:Insulin; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver; D008297:Male; D008315:Malondialdehyde / Q000032:analysis*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D010089:Oxidoreductases, N-Demethylating / Q000032:analysis / Q000378:metabolism; D011341:Probucol / Q000494:pharmacology*; D011887:Raffinose; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives
D016227:Benzoquinones; D005609:Free Radicals; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D014451:Ubiquinone; D008315:Malondialdehyde; D000493:Allopurinol; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating; D005982:Glutathione Transferase; D005978:Glutathione; C036619:idebenone; D000241:Adenosine; D011887:Raffinose; D011341:Probucol