title: Endometrium preparation with exogenous estradiol and progesterone for the transfer of cryopreserved blastocysts.
abstract: OBJECTIVE
  To determine the implantation rates of cryopreserved blastocysts using controlled E2 and P replacement cycles in women with functioning ovaries.
  
  
  METHODS
  Retrospective clinical study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Infertile women with cryopreserved blastocysts obtained from previous IVF attempts.
  
  
  METHODS
  Exogenous E2 was administered orally from cycle day 1 and P was started transvaginally from day 15. Blastocysts were transferred on the 5th day of endometrial exposure to P (day 19).
  
  
  METHODS
  Blastocyst implantation rate and pregnancy rate (PR).
  
  
  RESULTS
  Ninety-eight percent of blastocysts survived thawing: 67 were transferred in 42 women. Eight pregnancies occurred giving a PR of 19% per ET and 11.9% per blastocyst.
  
  
  CONCLUSIONS
  The high PR observed after transferring blastocysts on the 5th day of endometrial exposure to P in controlled E2 and P replacement cycles speaks for a forward slide of the window of transfer in case of blastocysts.
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital A. Bećlere, Clamart, France.
authors.forename: C
authors.initials: C
authors.lastname: Lelaidier
authors.forename: D
authors.initials: D
authors.lastname: de Ziegler
authors.forename: S
authors.initials: S
authors.lastname: Freitas
authors.forename: F
authors.initials: F
authors.lastname: Olivennes
authors.forename: A
authors.initials: A
authors.lastname: Hazout
authors.forename: R
authors.initials: R
authors.lastname: Frydman
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000502:physiology*; D015925:Cryopreservation; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000187:drug effects* / Q000502:physiology; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011374:Progesterone / Q000627:therapeutic use*; D012189:Retrospective Studies
chemical_list: D011374:Progesterone; D004958:Estradiol