Pharmacokinetics of ethyl biscoumacetate and its metabolite 7-hydroxy ethyl biscoumacetate in healthy volunteers.
Disposition kinetics of ethyl biscoumacetate and its metabolite 7-hydroxy ethyl biscoumacetate were evaluated in ten healthy volunteers, after a single 300 mg oral dose of ethyl biscoumacetate. Serum concentrations of parent compound and its metabolite were measured by HPLC. The maximum serum ethyl biscoumacetate concentrations were reached 1.0-4.0 hours after drug dosing. From 3 hours after drug administration the concentration of the metabolite was always higher than the concentration of the parent compound. Geometric mean of elimination half-life was 0.66 hours for ethyl biscoumacetate and 2.03 hours for the 7-hydroxy ethyl metabolite.
Perlík
F
F
1st Department of Medicine, Faculty of Medicine, Charles University, Prague, Czech Republic.
Patzelová
V
V
D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005017:Ethyl Biscoumacetate / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D012016:Reference Values
D005017:Ethyl Biscoumacetate; C075557:7-hydroxyethyl biscoumacetate