Monoclonal antibody S37 induces apoptosis in bovine T lymphoma cells.
Influences of 38 monoclonal antibodies (mAbs) on the growth of bovine T lymphoma cells (BTL-27) were examined. One of them, S37, inhibited the cell growth strikingly when it was added to the cultures. S37-treated cells showed DNA fragmentation containing approximately 200-base pair multiple patterns and chromatin condensation. This evidence suggested that mAb S37 induced apoptosis in BTL-27 cells.
Shinagawa
T
T
Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
Ishiguro
N
N
Horiuchi
M
M
Shinagawa
M
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D007136:Immunoglobulins / Q000494:pharmacology; D016399:Lymphoma, T-Cell / Q000662:veterinary*; D051379:Mice / Q000276:immunology; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D004279:DNA, Viral; D007136:Immunoglobulins