title: The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides.
abstract: The alpha/immediate early genes of herpes simplex virus are regulated by the specific assembly of a multiprotein enhancer complex containing the Oct-1 POU domain protein, the viral alpha-transinduction factor alpha TIF, (VP16, ICP25), and the C1 cellular factor. The C1 factor from mammalian cells is a heterogeneous but related set of polypeptides that interact directly with the alpha-transinduction factor to form a heteromeric protein complex. The isolation of cDNAs encoding the polypeptides of the C1 factor suggests that these proteins are proteolytic products of a novel precursor. The sequence of the amino termini of these polypeptide products indicate that the proteins are generated by site-specific cleavages within a reiterated 20-amino acid sequence. Although the C1 factor appears to be ubiquitously expressed, it is localized to subnuclear structures in specific cell types.
authors.affiliation: Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: T M
authors.initials: TM
authors.lastname: Kristie
authors.forename: J L
authors.initials: JL
authors.lastname: Pomerantz
authors.forename: T C
authors.initials: TC
authors.lastname: Twomey
authors.forename: S A
authors.initials: SA
authors.lastname: Parent
authors.forename: P A
authors.initials: PA
authors.lastname: Sharp
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D018076:DNA, Complementary; D004742:Enhancer Elements, Genetic; D006367:HeLa Cells; D017405:Herpes Simplex Virus Protein Vmw65 / Q000235:genetics* / Q000378:metabolism; D051863:Host Cell Factor C1; D006801:Humans; D007106:Immune Sera; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010455:Peptides; D011506:Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D018139:Simplexvirus / Q000235:genetics*; D018411:Spodoptera; D014157:Transcription Factors
chemical_list: D018076:DNA, Complementary; C497692:HCFC1 protein, human; D017405:Herpes Simplex Virus Protein Vmw65; D051863:Host Cell Factor C1; D007106:Immune Sera; D010455:Peptides; D011506:Proteins; D014157:Transcription Factors