[A study on the mechanism of invasion of colorectal mucinous adenocarcinoma].
Statistics from a 64 case study showed that mucinous adenocarcinoma was apt to invade the intestinal wall and to metastasize to lymph nodes (P < 0.05). The activity of arylsulfatase and lysozyme of mucinous adenocarcinoma was stronger than that of the papillary and tubular adenocarcinoma (P < 0.05). In RR staining for electron microscopic observation, a significant decrease of proteoglycan granules was found in the surrounding matrix of mucinous adenocarcinoma, which correlated with the amount of arylsulfatase and lysozyme secreted by mucinous adenocarcinoma. These enzymes reduced the degree of sulfation in heparan sulfate and degraded proteoglycans. The proteoglycan structural barrier having been destroyed, facilitates mucinous adenocarcinoma to infiltrate and metastasize.
Lou
S X
SX
Jinhua Central Hospital, Zhejiang.
Miao
D L
DL
Yi
Y F
YF
D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary; D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000556:secondary*; D000231:Adenocarcinoma, Papillary / Q000378:metabolism / Q000556:secondary; D001192:Arylsulfatases / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D009113:Muramidase / Q000378:metabolism; D009361:Neoplasm Invasiveness; D011509:Proteoglycans / Q000378:metabolism
D011509:Proteoglycans; D001192:Arylsulfatases; D009113:Muramidase