[An immunohistochemical study of Ki-67 expression of brain tumor cells and mononuclear cell subsets infiltrating these tumors].
Fifty-one brain tumors were studied by immunohistochemical methods. The densities of CD45RO+, CD4(OPD4) and CD8 T cells infiltrating the tumors showed negative correlation with the tumor size and positive correlation with the density of macrophages. The density of Ki-67+ tumor cells rose along with the increase in tumor malignancy and showed positive correlation with the tumor size and negative correlation with the density of CD4 T cells. The CD4/CD8 ratio was 0.853, far lower than the normal ratio and there was also positive correlation between their densities. The above results suggest that the level of Ki-67 expression can objectively reflect the proliferative rate and malignant grade of brain tumors. The CD45RO+, CD4 and CD8 T cells infiltrating brain tumors are able to directly inhibit tumor growth. The macrophages take part indirectly in the immunoresponse against brain tumors by influencing CD4 and CD8 T cells. Brain tumors may inhibit the proliferation and immune function of the CD4 subset.
Yu
S Z
SZ
Department of Neuropathology, Tianjin Medical College Hospital.
Zhang
J Q
JQ
Lü
G H
GH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001932:Brain Neoplasms / Q000276:immunology*; D016516:CD4-CD8 Ratio; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D017493:Leukocyte Common Antigens / Q000032:analysis; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology
D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D017493:Leukocyte Common Antigens