title: [Favorable results of paclitaxel (Taxol) in patients with ovary carcinoma pretreated with platinum].
abstract: OBJECTIVE
  To assess the anti-tumour and side effects of paclitaxel in patients with ovarian carcinoma, after prior treatment with al least one platinum-containing chemotherapy regimen.
  
  
  METHODS
  Phase II study.
  
  
  METHODS
  Academic Hospital of the Free University, Amsterdam.
  
  
  METHODS
  Fourteen of 55 patients with progressive ovarian carcinoma were treated with 135 mg/m2 and 41 with 175 mg/m2 paclitaxel. 9 patients by 24-hour and 46 by 3-hour intravenous infusion.
  
  
  RESULTS
  In 9/55 (16%) patients an objective tumour response was obtained, which was complete in 1 patient. In 19/55 (35%) patients the disease stabilised. The serum CA 125 level was increased in 52 patients. In 33% of the patients the course of the serum CA 125 was an indication of the tumour response. The median duration of response was 8 months (range 4.1-13.1) and the median duration of survival was 11.3 months (range 0.3-28.2). Side effects of paclitaxel treatment were hair-loss, arthralgia and myalgia and neutropenia of short duration. In 76% of patients pre-existing neurosensory symptoms increased mildly or developed de novo. The neurotoxic effect appeared reversible in most instances after discontinuation of the paclitaxel treatment.
  
  
  CONCLUSIONS
  In this rather unfavourable patient population, paclitaxel induced only 16% objective response. However, more than 50% of the patients did benefit from paclitaxel treatment, as a much larger group had long lasting disease stabilisation without symptoms or had reduction of symptoms. The treatment was well tolerated by most patients.
authors.affiliation: Afd. Geneeskundige Oncologie, Academisch Ziekenhuis Vrije Universiteit, Amsterdam.
authors.forename: K
authors.initials: K
authors.lastname: Hoekman
authors.forename: R V
authors.initials: RV
authors.lastname: Huijskes
authors.forename: C W
authors.initials: CW
authors.lastname: Burger
authors.forename: R H
authors.initials: RH
authors.lastname: Verheijen
authors.forename: H M
authors.initials: HM
authors.lastname: Pinedo
authors.forename: J B
authors.initials: JB
authors.lastname: Vermorken
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017671:Platinum Compounds / Q000008:administration & dosage*; D016019:Survival Analysis
chemical_list: D017671:Platinum Compounds; D017239:Paclitaxel
vernacular_title: Gunstig effect van paclitaxel (Taxol) bij patiënten met een met platina voorbehandeld ovariumcarcinoom.