Serum disappearance and urinary excretion of sulfamethoxypyridazine in goats.
Pharmacokinetics and urinary excretion of sulfamethoxypyridazine were determined in goats following single intravenous administration (100 mg/kg body weight). The disposition kinetics of sulfamethoxypyridazine could be best described by a 2-compartment open model. The distribution and elimination half life of the drug were 0.10 +/- 0.03 and 6.28 +/- 0.44 h, respectively. The values of apparent volume of distribution at steady state and total body clearance were found to be 0.39 +/- 0.02 l/kg and 0.73 +/- 0.06 ml/kg/min, respectively. The degree of acetylation was low as it ranged between 4.49 +/- 1.96 to 25.07 +/- 6.31% of the total drug in serum with an overall mean of 11.99 +/- 1.66%. Cumulative urinary excretion of sulfamethoxypyridazine was very low as only 2.97 +/- 0.50% of the total administered dose was excreted in urine during 24 h. The dosage regimen in goats would be 37.00 and 27.15 mg/kg body weight as the priming and maintenance doses respectively, to be repeated at 12 h intervals by intravenous route to achieve the bacteriostatic level of > or = 25 micrograms/ml.
Garg
S K
SK
Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, CSA University of Agriculture and Technology, Mathura, Inde.
Uppal
R P
RP
Rivière
J E
JE
D000818:Animals; D005260:Female; D006041:Goats / Q000378:metabolism*; D007194:India; D007275:Injections, Intravenous; D013421:Sulfamethoxypyridazine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D013421:Sulfamethoxypyridazine