[Nephroprotection by inhibition of the renin-angiotensin system--wish or reality?].
Angiotensin converting enzyme (ACE) inhibitors are used with increasing frequency in the treatment of hypertension in patients with chronic renal disease. In experimental models of chronic renal failure and, recently, in patients with diabetic nephropathy ACE inhibitors have also been shown to be effective on long-term administration in slowing the progression of renal failure. The exact mechanisms of this nephroprotective effect are not yet fully understood, but changes in hemodynamic parameters, a reduction of proteinuria and an inhibition of glomerular cell proliferation appear to be involved in preventing glomerulosclerosis.
Barnas
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U
Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Allgemeines Krankenhaus, Wien.
Mayer
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G
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000503:physiopathology; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors
Nephroprotektion durch Hemmung des Renin-Angiotensin-Systems--Wunsch oder Wirklichkeit?