title: Influence of exercise training and age on uncoupling protein mRNA expression in brown adipose tissue.
abstract: The ability to regulate body temperature diminishes with age. Exercise training is known to increase cardiovascular performance, and there is some evidence of a cross-adaptation between exercise and cold tolerance in young rats. The present study was designed to examine the effects of physical training by treadmill running on the capacity for brown adipose tissue (BAT) thermogenesis in young and old rats. To this end, we assessed BAT uncoupling protein (UCP) mRNA expression in sedentary and exercise-trained 5- and 25-mo-old F-344 rats. The amount of UCP mRNA, whether expressed as per unit RNA or per BAT, did not change with either age or training. These data indicate that there is no cross-adaptation by exercise on adaptive thermogenesis in BAT in either young or old rats.
authors.affiliation: Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608-1197.
authors.forename: P J
authors.initials: PJ
authors.lastname: Scarpace
authors.forename: S
authors.initials: S
authors.lastname: Yenice
authors.forename: N
authors.initials: N
authors.lastname: Tümer
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002352:Carrier Proteins / Q000096:biosynthesis*; D004597:Electroshock; D005260:Female; D007473:Ion Channels; D008565:Membrane Proteins / Q000096:biosynthesis*; D024101:Mitochondrial Proteins; D009929:Organ Size / Q000502:physiology; D010805:Physical Conditioning, Animal; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011916:Rats, Inbred F344; D014475:Uncoupling Agents / Q000378:metabolism*; D000071256:Uncoupling Protein 1
chemical_list: D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1