Gastric leiomyosarcoma: a clinicopathological review.
OBJECTIVE
To report our experience of eight patients with primary gastric leiomyosarcoma.


METHODS
Retrospective study.


METHODS
Teaching hospital, Taiwan.


METHODS
8 patients who presented with primary gastric leiomyosarcoma between 1986 and 1990.


METHODS
Endoscopic, radiological, and histopathological features, DNA ploidy, and outcome.


RESULTS
Abdominal pain and gastrointestinal bleeding were the most common presenting symptoms. In 5 of the 7 patients who had endoscopy preoperatively a diagnosis of submucosal tumour was made, but a definite diagnosis of leiomyosarcoma was made in only 3. A provisional diagnosis of leiomyosarcoma was made in 3 of the 4 patients who had computed tomography. All patients underwent some form of gastric resection ranging from palliative resection to total gastrectomy. Patients in whom the tumour had invaded adjacent organs had a poor prognosis. Histopathological grading of tumours correlated well with DNA ploidy.


CONCLUSIONS
Both histopathological grading and DNA ploidy could be helpful objective prognostic criteria in patients with primary gastric leiomyosarcoma.
Sheen-Chen
S M
SM
Department of Surgery, Pathology, Gastroenterology and Radiology, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung Medical College, Taiwan, R.O.C.
Chou
F F
FF
Eng
H L
HL
Chen
J J
JJ
Lee
C M
CM
Wan
Y L
YL
D000368:Aged; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
D004273:DNA, Neoplasm