title: Blood and urine concentrations of chemical pollutants in the general population.
abstract: The concentration of 9 environmental chemical pollutants in the general population was measured in blood and urine. For the 9 different pollutants, the blood samples tested varied from 88 for acetone to 431 for benzene. Urine samples varied from 48 for styrene to 213 for n-hexane. Six of these agents (benzene, toluene, styrene, n-hexane, acetone and carbon disulphide) were present in all or almost all (100-94%) blood samples. The three chlorides (chloroform, trichloroethylene and tetrachloroethylene) were present only in 60-85% of samples. After acetone, with blood concentrations in microgram/1 (mean 840 microgram/l), the highest mean blood levels were those of toluene (1097 ng/l), chloroform (955 ng/l) and n-hexane (642 ng/l). Trichloroethylene and free carbon disulphide showed similar values (458 and 438 ng/l, respectively). Finally, benzene, styrene and tetrachloroethylene showed the lowest values (262, 217 and 149 ng/l, respectively). There was generally a significant difference between rural and urban workers in terms of blood benzene (200 ng/l vs 264 ng/l), trichloroethylene (180 ng/l vs 763 ng/l) and tetrachloroethylene (62 ng/l vs 263 ng/l). In a group of subjects potentially exposed to industrial solvents, classed as chemical workers, blood benzene, toluene, chloroform and n-hexane were significantly higher than in rural and urban workers. Smokers showed a significantly higher blood concentration than non-smokers for benzene (381 ng/l vs 205 ng/1), toluene (1431 ng/l vs 977 ng/l), and n-hexane (838 ng/l vs 532 ng/l). All or almost all urine samples (100-92%) contained all the compounds except trichloroethylene and tetrachloroethylene, present in 79% and 76% of samples, respectively (table 2). Urinary concentrations of all compounds did not differ significantly between rural and urban workers. Benzene and toluene were significantly higher in in urine of smokers than of non-smokers. Chloroform and n-hexane showed significantly higher urinary than blood values. Excluding acetone, with urinary and blood concentrations in pg/l, chloroform, toluene and n-hexane showed the highest mean concentrations both in blood and in urine.
authors.affiliation: Istituto Medicina del Lavoro, Ospedale Policlinico, Verona.
authors.forename: F
authors.initials: F
authors.lastname: Brugnone
authors.forename: L
authors.initials: L
authors.lastname: Perbellini
authors.forename: C
authors.initials: C
authors.lastname: Giuliari
authors.forename: M
authors.initials: M
authors.lastname: Cerpelloni
authors.forename: M
authors.initials: M
authors.lastname: Soave
mesh_terms: D000096:Acetone / Q000097:blood / Q000652:urine; D000393:Air Pollutants / Q000097:blood* / Q000652:urine*; D001554:Benzene / Q000032:analysis; D002246:Carbon Disulfide / Q000097:blood / Q000652:urine; D002725:Chloroform / Q000097:blood / Q000652:urine; D002849:Chromatography, Gas; D006586:Hexanes / Q000097:blood / Q000652:urine; D006801:Humans; D013058:Mass Spectrometry; D012907:Smoking; D012984:Software; D020058:Styrene; D013343:Styrenes / Q000097:blood / Q000652:urine; D013750:Tetrachloroethylene / Q000097:blood / Q000652:urine; D014050:Toluene / Q000097:blood / Q000652:urine; D014241:Trichloroethylene / Q000097:blood / Q000652:urine; D014505:Urban Population
chemical_list: D000393:Air Pollutants; D006586:Hexanes; D013343:Styrenes; D000096:Acetone; D014241:Trichloroethylene; C026385:n-hexane; D014050:Toluene; D020058:Styrene; D002725:Chloroform; D001554:Benzene; D002246:Carbon Disulfide; D013750:Tetrachloroethylene