title: Glucose-induced inactivation of isocitrate lyase in Aspergillus nidulans.
abstract: The existence of a second mechanism of catabolite control of isocitrate lyase of Aspergillus nidulans, in addition to the carbon catabolite repression phenomenon recently reported was analysed. Isocitrate lyase was rapidly and specifically inactivated by glucose. The inactivation was irreversible at all stages in the presence of cycloheximide, showing that reactivation depends on de novo protein synthesis. In addition, analysis of glucose-induced inactivation of isocitrate lyase in a creAd-30 strain showed that the creA gene is not involved in this process.
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá de Henares, Madrid, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: De Lucas
authors.forename: S
authors.initials: S
authors.lastname: Valenciano
authors.forename: F
authors.initials: F
authors.lastname: Laborda
authors.forename: G
authors.initials: G
authors.lastname: Turner
mesh_terms: D001233:Aspergillus nidulans / Q000201:enzymology*; D003513:Cycloheximide; D004789:Enzyme Activation; D004794:Enzyme Repression / Q000235:genetics; D005947:Glucose / Q000494:pharmacology*; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D003513:Cycloheximide; D007522:Isocitrate Lyase; D005947:Glucose