Effects of vindesine on hypothalamic-pituitary-adrenal axis.
Vindesine, a cell-cycle-specific agent currently employed in the treatment of some neoplasias, was able to produce a remarkable dose-dependent adrenocortical activation, but it was unable to increase plasma corticosterone in hypophysectomized rats in vivo. In addition, vindesine was able to increase ACTH release in vitro when tested on isolated pituitary cells in culture suggesting a direct involvement of the pituitary gland in the increase of adrenal secretion in vivo.
Brunetti
L
L
Department of Pharmacology and Pharmacognosy, G. D'Annunzio University, Chieti, Italy.
Preziosi
P
P
Ragazzoni
E
E
Vacca
M
M
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D003345:Corticosterone / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014751:Vindesine / Q000494:pharmacology*
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D014751:Vindesine; D003345:Corticosterone