[Incidence of acral nodulosis with long-term methotrexate therapy in patients with inflammatory rheumatic diseases].
The significance of acral nodulosis under methotrexate therapy is still controversial. Among patients with rheumatoid arthritis and methotrexate therapy this manifestation could be observed in 8/163 (5%). All cases were seropositive and already treated with other LAAD. Patients with other inflammatory rheumatic diseases under methotrexate therapy (n = 83) did not develop this nodulosis. The acral nodulosis is interpreted as a typical side-effect of methotrexate only in patients with rheumatoid arthritis. Histopathologically, these nodules do not differ from the typical rheumatoid nodule.
Wagener
P
P
Rheumazentrum Hannover.
D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006227:Hand Deformities, Acquired / Q000139:chemically induced*; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D012218:Rheumatoid Nodule / Q000139:chemically induced*
D008727:Methotrexate
Die Häufigkeit einer akralen Nodulosis unter Methotrexat-Langzeittherapie bei Patienten mit entzündlich-rheumatischen Erkrankungen.