[Clinical and experimental study on effect of Chinese herbal drugs on producing prostaglandin in gastric mucosa].
The PG content were determined in 62 cases with peptic ulcer and erosive gastritis before and after the treatment of Chinese herbal drugs. The value of PGE2,PGF1 alpha, 6-keto-PGF1 alpha and TXB2 were 96.25 +/- 28.51, 14.24 +/- 13.26, 10.72 +/- 9.14 and 16.51 +/- 12.24 pg/mg respectively before the treatment and were 121.42 +/- 30.02, 18.59 +/- 18.40, 18.79 +/- 12.61, 8.29 +/- 6.27 pg/mg respectively after the treatment. 6-keto-PGF1 alpha was significantly increased (P < 0.01), TXB2 was decreased (P < 0.01), but there were no significant changes in PGE2 and PGF1 alpha. Experimental study also showed that Chinese Herbal drugs played an important role in protecting indomethacine induced ulcer rats.
Wang
C H
CH
Military General Hospital of Shen yang.
Wang
Y H
YH
Zhou
Y
Y
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D013929:Thromboxane B2 / Q000096:biosynthesis*
D004365:Drugs, Chinese Herbal; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone