Itraconazole for the treatment of histoplasmosis in cats.
Eight cats with histoplasmosis were treated with itraconazole at 5 mg/kg per dose PO bid. There were multiple sites of infection, and 2 of the cats had hypercalcemia that was attributed to the histoplasmosis. All 8 cats were eventually cured, but 2 cats experienced recurrences of disease after completion of therapy, requiring 2 to 3 additional months of itraconazole. There were no clinically relevant adverse effects during treatment. Although a limited number of cats were treated, the study suggests that itraconazole is a well-tolerated and effective drug for the treatment of histoplasmosis in the cat.
Hodges
R D
RD
Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
Legendre
A M
AM
Adams
L G
LG
Willard
M D
MD
Pitts
R P
RP
Monce
K
K
Needels
C C
CC
Ward
H
H
D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000382:microbiology; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D004361:Drug Tolerance; D005260:Female; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000188:drug therapy / Q000662:veterinary*; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D012008:Recurrence; D016896:Treatment Outcome
D017964:Itraconazole