title: Regional cerebral blood flow and CO2 reactivity in fulminant hepatic failure.
abstract: Alterations in cerebral hemodynamics are postulated to contribute to brain herniation, a major cause of death in patients with severe hepatic encephalopathy due to fulminant hepatic failure (FHF). In an effort to identify these changes in cerebral hemodynamics, regional and global cerebral blood flow (CBF) and CO2 reactivity were measured using stable xenon-enhanced computed tomography (Xe/CT) in 24 patients within 72 h of onset of severe hepatic encephalopathy. Regional variations in CBF, most notably, a relative decrease in CBF in the anterior circulation and an increase in CBF in the posterior circulation were found. CBF was significantly lower in FHF patients compared with controls, however, these values are well out of the established ischemic range. FHF patients also showed significant impairment in CBF response to hypoventilation, while the CBF response to hyperventilation remained intact. This study suggests that FHF patients demonstrate early changes in both CBF patterns and CO2 reactivity. The relatively "normal" CBF values obtained in FHF patients in severe hepatic encephalopathy coupled with the lack of vasodilatation to hypoventilation suggest a state of uncoupled CBF and metabolism or "luxury perfusion" that could theoretically contribute to vasogenic edema, brain swelling, and cerebral herniation.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: S
authors.initials: S
authors.lastname: Durham
authors.forename: H
authors.initials: H
authors.lastname: Yonas
authors.forename: S
authors.initials: S
authors.lastname: Aggarwal
authors.forename: J
authors.initials: J
authors.lastname: Darby
authors.forename: D
authors.initials: D
authors.lastname: Kramer
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D005260:Female; D006501:Hepatic Encephalopathy / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
chemical_list: D002245:Carbon Dioxide