Systemic infection with Herpes bovis virus 2 evokes a biphasic immune response in the mouse.
We evaluated the effects of systemic infection by Herpes bovis virus 2 (HBV-2) on a murine experimental system. We provide evidence that such infection is lethal for the immunocompromised but not for the immunocompetent mouse in which a biphasic immune response is elicited. In particular, 1 day post-infection, we observed a rapid transient depression induced by the virus, as documented by a decrease in peripheral leukocyte counts, mitogenic spleen cell response and resistance to a secondary microbial challenge. Later, HBV-2 infection boosted cytokine secretion and enhanced antimicrobial and antitumoral activities by the splenic district. In conclusion, our experimental model discloses some immunological aspects underlying the complex host-virus interaction.
Puliti
M
M
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
Cenci
E
E
Vecchiarelli
A
A
Blasi
E
E
Merletti
L
L
D000818:Animals; D002177:Candidiasis / Q000150:complications; D005260:Female; D006561:Herpes Simplex / Q000150:complications / Q000276:immunology* / Q000401:mortality; D001911:Herpesvirus 2, Bovine / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology* / Q000528:radiation effects; D007113:Immunity, Innate / Q000528:radiation effects; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000276:immunology; D014766:Viremia