Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs.
Alterations in left atrial (LA) and left ventricular (LV) compliance and arterial and coronary sinus atrial natriuretic factor (ANF) concentrations at baseline and in response to both volume depletion and expansion were investigated in 15 conscious dogs with aortic banding-induced LV hypertrophy (LVH) (LV/body wt increased by 64%), which also induced LAH (LA/body wt increased by 61%). With volume expansion coronary sinus ANF increased more (P < 0.05) in dogs with LVH (+427 +/- 88 pg/ml) compared with control dogs (+146 +/- 45 pg/ml). Arterial ANF levels also rose more with volume expansion in LVH. In dogs with LVH, the LV end-diastolic pressure-diameter relationship was shifted to the left with a steeper slope with volume expansion, such that at any given diastolic dimension, diastolic pressure was higher. In contrast, the pressure-dimension relationship for the LA appendage was shifted in the opposite direction during both atrial systolic and diastolic phases, with a more shallow slope in hypertrophy compared with control dogs, resulting in an augmented pressure-dimension product during volume loading in LAH. In conclusion, in dogs with LVH and LAH, enhanced ANF was revealed in the coronary sinus and systemic circulation during volume expansion, which could be due, in part, to a more compliant, but hypertrophied, LA, which responded to equivalent volume loading with an augmented pressure-dimension product.
Hasebe
N
N
Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Boston, Massachusetts 02115.
Hittinger
L
L
Kohin
S
S
Shen
Y T
YT
Graham
R M
RM
Vatner
S F
SF
D000818:Animals; D001011:Aorta; D016279:Atrial Function, Left; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D001810:Blood Volume; D006332:Cardiomegaly / Q000503:physiopathology*; D003187:Compliance; D003250:Constriction; D004285:Dogs; D006439:Hemodynamics; D009994:Osmolar Concentration; D010952:Plasma Substitutes / Q000494:pharmacology; D016277:Ventricular Function, Left
D010952:Plasma Substitutes; D009320:Atrial Natriuretic Factor