Perinatal mortality in eclampsia in relation to drug therapy.
Fifty-nine babies were born to eclamptic mothers among 7500 deliveries giving incidence of occurrence of 0.77 percent. The perinatal mortality in eclamptic babies was 32.7%, whereas the total perinatal mortality rate amongst all the deliveries was 10.5%. The mothers were treated within Group I--diazepam, Group II i chlorpromazine (largactil), phenargan and diazepam and Group III--largactil, phethidine and phenargan. The mortality rate was 23.8%, 18.8% and 66.6% respectively. The highest number of still-born i.e. six out of 8 occurred in Group III. Hundred percent still-born was noted in 28-32 weeks of gestation and birth weight less than 1.5 kg irrespective of drug regimes. Iargactil potentiates the respiratory depressant effect of pethidine and may cause high rate of still-birth and death after birth.
Chaudhuri
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N
Department of Pediatrics, R.G. Kar Medical College, Calcutta.
Dasgupta
P
P
Pan
N R
NR
D000328:Adult; D001724:Birth Weight; D002746:Chlorpromazine / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004461:Eclampsia / Q000188:drug therapy*; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D006801:Humans; D007194:India; D007226:Infant Mortality; D007231:Infant, Newborn; D008614:Meperidine / Q000627:therapeutic use; D011247:Pregnancy; D011398:Promethazine / Q000627:therapeutic use
D008614:Meperidine; D011398:Promethazine; D003975:Diazepam; D002746:Chlorpromazine