The influence of fibroblasts on the growth of human colorectal carcinoma xenografts.
Colorectal carcinoma xenografts were grown in nude mice by inoculation with and without fibroblasts. A significantly greater proportion of tumours grew in mice receiving carcinoma cells with fibroblasts (83% compared to 52%). Tumour weight and thymidine DNA labelling were not significantly different. Initial development but not subsequent growth of xenografts was enhanced by fibroblasts.
Hennigan
T W
TW
Department of Surgery, Charing Cross Hospital, London, UK.
Allen-Mersh
T G
TG
D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013936:Thymidine / Q000493:pharmacokinetics
D013936:Thymidine