Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma.
OBJECTIVE
To evaluate the efficacy of transforming growth factor beta (TGF-beta) for the prognosis of pulmonary adenocarcinoma.


METHODS
TGF-beta was detected immunohistochemically using the avidin-biotin-peroxidase complex technique in resected pulmonary adenocarcinomas from 88 patients.


RESULTS
Of the 88 patients, 39 were TGF-beta negative and 45 TGF-beta positive. The five year survival rate was 56% for the TGF-beta negative and 16% for the TGF-beta positive group.


CONCLUSIONS
TGF-beta can be used as a prognostic factor in pulmonary adenocarcinoma.
Takanami
I
I
Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.
Imamura
T
T
Hashizume
T
T
Kikuchi
K
K
Yamamoto
Y
Y
Kodaira
S
S
D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016612:Paraffin Embedding; D011379:Prognosis; D016212:Transforming Growth Factor beta / Q000032:analysis*
D016212:Transforming Growth Factor beta