title: A chromosome study on 97 cases of acute nonlymphocytic leukemia M2.
abstract: Chromosomal studies were performed in the same laboratory on 97 untreated cases of de novo acute nonlymphocytic leukemia M2. The overall incidence of chromosomal abnormality was 70.1% (68 out of 97 cases), which was higher in children (84.2%) than in adults (61%). The male to female chromosomal abnormality ratio was nearly the same (male 71% and female 68.4%, P > 0.05). Hypodiploidy was the most common numerical abnormality (39%) and t (8; 21) was the most common structural abnormality (48.1%). In the patients with t(8; 21), 64.5% (20 out of 31 cases) male lost chromosome Y (-Y) and 33% (5 out of 15 cases) female lost one chromosome X (-X).
authors.affiliation: Research Institute of Hematology, Xiehe Hospital, Tongji Medical University, Wuhan.
authors.forename: F J
authors.initials: FJ
authors.lastname: Chen
authors.forename: A D
authors.initials: AD
authors.lastname: Yang
authors.forename: H B
authors.initials: HB
authors.lastname: Fei
mesh_terms: D000328:Adult; D002648:Child; D002872:Chromosome Deletion; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014960:X Chromosome; D014998:Y Chromosome