Translocation (2;3)(p22;q28) is associated with myeloid disorders.
Chromosome studies carried out in two children with acute myeloblastic leukemia (AML, M2) showed a t(2;3)(p22;q28). This abnormality was associated with monosomy 7 and del(12)(p12) in the first patient and was found only in relapse in the second patient. Comparison with the other previously published t(2;3) suggests that this translocation is a nonrandom abnormality involving a pluripotent stem cell and occurring as a secondary chromosome abnormality in AML.
Berger
R
R
INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Flexor
M
M
Le Coniat
M
M
Derré
J
J
Leblanc
T
T
D002648:Child; D002675:Child, Preschool; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic