title: Translocation (2;3)(p22;q28) is associated with myeloid disorders.
abstract: Chromosome studies carried out in two children with acute myeloblastic leukemia (AML, M2) showed a t(2;3)(p22;q28). This abnormality was associated with monosomy 7 and del(12)(p12) in the first patient and was found only in relapse in the second patient. Comparison with the other previously published t(2;3) suggests that this translocation is a nonrandom abnormality involving a pluripotent stem cell and occurring as a secondary chromosome abnormality in AML.
authors.affiliation: INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: M
authors.initials: M
authors.lastname: Flexor
authors.forename: M
authors.initials: M
authors.lastname: Le Coniat
authors.forename: J
authors.initials: J
authors.lastname: Derré
authors.forename: T
authors.initials: T
authors.lastname: Leblanc
mesh_terms: D002648:Child; D002675:Child, Preschool; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic