[Receptor mechanisms of antiepileptic drug action].
The recent findings on pathogenesis of epileptic seizures indicate their disturbance in balance between excitatory and inhibitory processes in neurocytes. Important neurotransmitters, of excitatory or inhibitory activity, are: gamma-aminobutyric acid, glutamate and aspartate. The neurotransmitters act by activation of specific receptors: GABA-A, GABA-B, NHDA receptors, quis and kain. The receptor mechanisms of important antiepileptic drugs are discussed. The recent research on new antiepileptic drugs include those enhancing neuronal inhibition, and those diminishing neuronal excitation.
Janiec
K
K
I Katedry i Kliniki Neurologii Slaskiej Akademii Medycznej, Katowice.
D000927:Anticonvulsants / Q000494:pharmacology*; D001665:Binding Sites; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D017459:Receptors, Amino Acid / Q000187:drug effects*
D000927:Anticonvulsants; D017459:Receptors, Amino Acid
Receptorowe mechanizmy działania leków przeciwpadaczkowych.