The potential for bidirectional promoter activity of the human PDGF-A chain gene.
Platelet-derived growth factor (PDGF) is a heterodimeric glycoprotein consisting of A and B chains. A functional promoter had been identified in the 5' flanking region of the human PDGF-A chain gene. We found that the PDGF-A chain promoter region possesses the potential for bidirectional activity. This bidirectional promoter activity is influenced by the 5'-untranslated region (5'-UTR) and serum concentration. The 5'-UTR may regulate expression of the PDGF-A chain by transcription in the opposite direction.
Takimoto
Y
Y
Department of Internal Medicine, Hiroshima University, Japan.
Kuramoto
A
A
D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics / Q000502:physiology*; D018233:Rhabdomyosarcoma, Embryonal; D014407:Tumor Cells, Cultured
D010982:Platelet-Derived Growth Factor; C075278:platelet-derived growth factor A; D015500:Chloramphenicol O-Acetyltransferase