Reproductive effects of inorganic borates on male employees: birth rate assessment.
The purpose of this study was to investigate the potential for reproductive effects of inorganic borate compounds on male employees. The standardized birth ratio (SBR) methodology was used to assess fertility among male employees, using live births as the measured end point. The ratio of female to male births was also assessed. Data were collected via questionnaires and telephone follow-up interviews. Medical insurance records were assessed for nonresponders. Exposures were assessed using three semiquantitative categories. We found a statistically significant increase in fertility as measured by live births among the employees of the inorganic borate facility. There does not appear to be any decrease in fertility due to exposures either as analyzed by the borate exposure categories or over time, which is an indirect measure of exposures. We found a nonstatistically significant increase in the percentage of female offspring. This increase was due, not to a deficiency of male offspring, but rather to a marked increase in the numbers of female offspring. This increase in percentage female offspring does not appear to be related to exposures to inorganic borates. Based on the data, exposures to inorganic borates do not appear to adversely affect fertility in this population.
Whorton
D
D
ENSR Health Services, Alameda, CA 94502.
Haas
J
J
Trent
L
L
D001723:Birth Rate; D001881:Borates / Q000009:adverse effects*; D005260:Female; D005298:Fertility / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*; D011247:Pregnancy; D012307:Risk Factors; D012744:Sex Ratio
D001881:Borates