title: Occupational allergy to adult chironomid midges among environmental researchers.
abstract: A case of occupational allergy to chironomid midges in research work is described. A researcher was exposed to adult chironomid midges during his research and developed allergic rhinitis after 10 years of such exposure. Using the midge extract of adult Chironomus plumosus (CP) (Linnaeus, 1758), both immediate skin test and the ophthalmic challenge test gave positive results. IgE antibody against adult CP was also demonstrated by the radioallergosorbent test. Four of the five serum samples of the environmental researcher examined showed a positive radioallergosorbent test to at least one of the adult midges breeding around eutrophic Japanese lakes. Enzyme-linked immunosorbent assay inhibition test and immunoblot experiments indicated that the remaining hemoglobin is one of the major allergens of adult CP. These results demonstrate that the exposure to adult chironomid midges is an important occupational hazard among environmental researchers.
authors.affiliation: Department of Public Health, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Teranishi
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: G
authors.initials: G
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Miyao
authors.forename: M
authors.initials: M
authors.lastname: Kasuya
mesh_terms: D000328:Adult; D000818:Animals; D002683:Chironomidae / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D015151:Immunoblotting; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000276:immunology*; D011852:Radioallergosorbent Test; D012108:Research Personnel
chemical_list: D007073:Immunoglobulin E