Inhibition of T-cell activation by an anti-human class I MHC reactive monoclonal antibody occurs at a point distal to TCR-CD3 mediated signal transduction.
Smith
D M
DM
Department of Surgery, University of Chicago, IL 60637.
Bluestone
J A
JA
Thistlethwaite
J R
JR
Woodle
E S
ES
D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001360:Avidin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D015759:Ionomycin / Q000494:pharmacology; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects; D008285:Major Histocompatibility Complex; D016853:Muromonab-CD3 / Q000494:pharmacology; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I; D016853:Muromonab-CD3; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D001360:Avidin; D015759:Ionomycin; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium