Genes of stress in experimental hypertension.
1. A significant portion of blood pressure variance is modified by the environment. 2. The present report summarizes evidence that: (i) the environmental response is genetically determined; (ii) various stressors can evoke a differential response in hypertensive animals and constitute its intermediate phenotypes; (iii) the response to heat stress can be assigned to a single 'thermosensitivity' locus; (iv) candidate genes of susceptibility to environmental stresses are member(s) of the heat stress gene (HSP) gene families; (v) a restriction fragment length polymorphism of hsp70 and a single base mutation in the 3'-untranslated region of hsp27 are associated with hypertension in recombinant inbred strains. 3. In conclusion, HSP gene variants may be causative in susceptibility to hypertension.
Hamet
P
P
Centre de recherche Hôtel-Dieu de Montréal, Université de Montréal, Canada.
Sun
Y L
YL
Malo
D
D
Kong
D
D
Kren
V
V
Pravenec
M
M
Kunes
J
J
Dumas
P
P
Richard
L
L
Gagnon
F
F
D000818:Animals; D004195:Disease Models, Animal; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics; D006360:Heat-Shock Proteins / Q000235:genetics*; D006973:Hypertension / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D010641:Phenotype; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins