title: Ultrastructure and immunohistochemistry of the embryonic type of fat identified in the human infant breast.
abstract: In this paper we describe the light and electron microscopic appearance of the embryonic type of fat in human infant breast, together with immunocytochemical findings. This fat tissue was composed of numerous capillaries surrounded by a mixed population of undifferentiated mesenchymal cells and preadipocytes at various stages of differentiation. The preadipocytes were characterised by a number of cytoplasmic processes, varying numbers of lipid droplets, and an envelope of electrondense material outside the cell membrane. Immunocytochemistry showed a characteristic distribution of collagen type IV adjacent to and vimentin and S100 protein within the preadipocytes. This is the first report of the ultrastructure of the human mammary embryonic type of fat. The possible role of the embryonic type of fat in the development and growth of the human breast is discussed.
authors.affiliation: Section of Cell Biology and Experimental Pathology, Haddow Laboratories, Sutton, Surrey, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Anbazhagan
authors.forename: B A
authors.initials: BA
authors.lastname: Gusterson
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry / Q000196:embryology* / Q000648:ultrastructure; D001940:Breast / Q000648:ultrastructure*; D002454:Cell Differentiation; D003094:Collagen / Q000032:analysis / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008648:Mesoderm / Q000737:chemistry* / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009418:S100 Proteins / Q000032:analysis / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis / Q000648:ultrastructure
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D003094:Collagen