Use of ketorolac in the prevention of suxamethonium myalgia.
We have evaluated the effect of ketorolac in the prevention of suxamethonium myalgia. Sixty ASA I patients who presented for extraction of wisdom teeth as day cases were allocated randomly to one of three equal groups. Patients received either 0.9% saline (placebo), atracurium 0.05 mg kg-1 i.v. or ketorolac 10 mg i.v., 3 min before induction of anaesthesia. Follow-up postal questionnaires (97% response rate) at 48 h showed no reduction in the incidence of myalgia after ketorolac pretreatment compared with saline. The use of atracurium reduced the incidence of myalgia by 60% (P < 0.001) and the severity of fasciculations (P < 0.001). There was no difference in the severity of fasciculations between the saline and ketorolac groups. Intubating conditions were comparable in the three groups.
Leeson-Payne
C G
CG
University Department of Anaesthesia, Queen's Medical Centre, Nottingham.
Nicoll
J M
JM
Hobbs
G J
GJ
D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D001279:Atracurium / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020910:Ketorolac; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000517:prevention & control*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D011292:Premedication; D013390:Succinylcholine / Q000009:adverse effects*; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014081:Tooth Extraction
D000700:Analgesics; D001279:Atracurium; D014046:Tolmetin; D013390:Succinylcholine; D020910:Ketorolac