title: Cytogenetic study of tuberculosis patients before and after tuberculostatic drug treatment.
abstract: Cytogenetic analyses were carried out in lymphocytes of 15 untreated tuberculosis (tb) patients and 15 other tb patients who had received combined tuberculostatic chemotherapy HRZ (isoniazid+rifampicin+pyrazinamide) for 2 months. The frequency of chromosomal aberrations and sister-chromatid exchanges (SCEs) did not show any statistically significant differences in the patients before treatment and after exposure to combined HRZ therapy as compared to controls (p > 0.05). However, we observed that the mitotic index was significantly decreased in both groups (p < 0.05). Based on the results of the present study, we believe there is no indication for a chromosome damaging effect of HRZ and their metabolites in human lymphocytes in vivo after treatment of tuberculosis patients with optimum doses.
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ekmekçi
authors.forename: A
authors.initials: A
authors.lastname: Sayli
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D002455:Cell Division / Q000187:drug effects; D002869:Chromosome Aberrations; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009153:Mutagens; D011718:Pyrazinamide / Q000008:administration & dosage / Q000009:adverse effects*; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*; D012854:Sister Chromatid Exchange; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000995:Antitubercular Agents; D004338:Drug Combinations; D009153:Mutagens; C087181:isoniazid, pyrazinamide, rifampin drug combination; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin