title: Degeneration model of the porcine lumbar motion segment: effects of various intradiscal procedures.
abstract: In an experimental study with 18 minipigs, we have tried to establish a model for the standardized evaluation of mechanical, histological and radiological phenomena of degenerative and reparative processes within the lumbar motion segment. Comparing different operative techniques revealed that the intradiscal application of hyaluronic acid into the nuclear defect is likely to enhance the regeneration process. Using the measurement of disc compliance, a semiautomatic picture analyzer and a new semiquantitative disc score could make future studies more comparable. From this basis, the intradiscal application of hyaluronic acid deserves further evaluation.
authors.affiliation: Orthopdische Klinik, Philipps Universität, Marburg/Lahn, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Pfeiffer
authors.forename: P
authors.initials: P
authors.lastname: Griss
authors.forename: P
authors.initials: P
authors.lastname: Franke
authors.forename: C
authors.initials: C
authors.lastname: Bornscheuer
authors.forename: J
authors.initials: J
authors.lastname: Orth
authors.forename: A
authors.initials: A
authors.lastname: Wilke
authors.forename: J D
authors.initials: JD
authors.lastname: Clausen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006820:Hyaluronic Acid / Q000627:therapeutic use; D007404:Intervertebral Disc Chemolysis; D008159:Lumbar Vertebrae / Q000473:pathology / Q000503:physiopathology*; D011312:Pressure; D011897:Random Allocation; D012038:Regeneration / Q000187:drug effects; D013122:Spinal Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013552:Swine; D013556:Swine, Miniature
chemical_list: D006820:Hyaluronic Acid