title: Prenatal ultrasonic diagnosis of obstructive bowel disease: a retrospective analysis.
abstract: Fetal obstructive bowel disease was diagnosed in 29 patients at 22-37 weeks (median 32 weeks) of gestation, seven (24 per cent) of whom also displayed other anomalies. Polyhydramnios was present in 20/29 cases (69 per cent). An abnormal karyotype existed in 7/29 cases (24 per cent), of which six were diagnosed prenatally (trisomy 21, n = 5; 69,XXX, n = 1) and one postnatally (trisomy 21). There was always an association with the ultrasonic 'double bubble' sign. Obstructive bowel disease was confirmed postnatally in 20/29 (69 per cent) cases, i.e., oesophageal atresia (n = 1), duodenal obstruction (n = 12), and small bowel obstruction (n = 7). Other anomalies existed in 6/29 (21 per cent) cases, i.e., multicystic kidney (n = 1) and multiple congenital anomalies (n = 5). The perinatal mortality rate was 35 per cent (7/20).
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Hospital Rotterdam-Dijkzigt, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Heydanus
authors.forename: M C
authors.initials: MC
authors.lastname: Spaargaren
authors.forename: J W
authors.initials: JW
authors.lastname: Wladimiroff
mesh_terms: D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations / Q000000981:diagnostic imaging / Q000235:genetics; D025063:Chromosome Disorders; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007415:Intestinal Obstruction / Q000151:congenital / Q000000981:diagnostic imaging* / Q000235:genetics; D007621:Karyotyping; D006831:Polyhydramnios / Q000000981:diagnostic imaging; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal