Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3.
Two highly polymorphic CA-repeat microsatellites (D21S1224 and D21S1261) are reported. The clones containing these CA-repeats (ABM-C60 and ABM-C29) have been isolated from a human chromosome-21-specific library (LA21NS01) and have been localised to the q22.3 band using a specific chromosome 21 somatic cell hybrid panel. Both polymorphisms showed heterozygosities of 0.83 in the unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These new markers should improve the map of the 21q22.3 region, which is believed to contain a large number of genes.
Bosch
A
A
Molecular Genetics Department, Cancer Research Institute (IRO), Hospital Duran i Reynals, Barcelona, Catalunya, Spain.
Guimerà
J
J
Wiemann
S
S
Ansorge
W
W
Patterson
D
D
Estivill
X
X
D001483:Base Sequence; D002891:Chromosomes, Human, Pair 21 / Q000737:chemistry / Q000235:genetics*; D017931:DNA Primers; D004276:DNA, Satellite / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D018598:Minisatellite Repeats; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
D017931:DNA Primers; D004276:DNA, Satellite