title: Longitudinal changes in symptoms and plasma homovanillic acid levels in chronically medicated schizophrenic patients.
abstract: A correlation has been noted between the changes in plasma homovanillic acid concentrations and changes in psychiatric symptoms induced by neuroleptic treatment. Our objective was to determine whether plasma homovanillic acid concentration changed in accordance with the changes in symptoms over time. Twenty-eight chronically medicated schizophrenic inpatients received the same treatment regimen for 1 year. Symptoms and plasma homovanillic acid concentrations were examined every month and whenever conditions deteriorated. Plasma homovanillic acid concentrations were significantly higher in the patients in the worst condition than in the patients in the best condition. Further, when comparing the best and worst conditions of both the positive and negative symptoms, the change in psychiatric rating of positive and negative symptoms was correlated significantly with the change in plasma homovanillic acid level. These results suggest that a change in plasma homovanillic acid concentration can be produced not only by neuroleptic-induced dopaminergic blocking but also by a change in positive and negative symptoms of schizophrenia.
authors.affiliation: Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Kanba
authors.forename: M
authors.initials: M
authors.lastname: Nibuya
authors.forename: S
authors.initials: S
authors.lastname: Adachi
authors.forename: U
authors.initials: U
authors.lastname: Sekiya
authors.forename: F
authors.initials: F
authors.lastname: Shintani
authors.forename: N
authors.initials: N
authors.lastname: Kinoshita
authors.forename: G
authors.initials: G
authors.lastname: Yagi
authors.forename: M
authors.initials: M
authors.lastname: Asai
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001143:Arousal / Q000187:drug effects; D002908:Chronic Disease; D006719:Homovanillic Acid / Q000097:blood*; D006760:Hospitalization; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D006719:Homovanillic Acid