gp120-mediated alterations in astrocyte ion transport.
The pathogenesis of the acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) is unknown. However, recent work indicates that neurons and astrocytes are functionally compromised by exposure to viral components or cellular factors released from HIV-1-infected macrophages/microglia. We show that exposure of primary cultured rat astrocytes to the major HIV envelope glycoprotein gp120 results in alterations of ion and solute transport that may contribute to neuronal cell injury.
Benos
D J
DJ
Department of Physiology and Biophysics, University of Alabama at Birmingham 35294.
Hahn
B H
BH
Shaw
G M
GM
Bubien
J K
JK
Benveniste
E N
EN
D015526:AIDS Dementia Complex / Q000209:etiology; D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000821:virology*; D001692:Biological Transport; D018698:Glutamic Acid / Q000378:metabolism; D015699:HIV Envelope Protein gp120 / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers / Q000187:drug effects / Q000378:metabolism*
D015699:HIV Envelope Protein gp120; D009419:Nerve Tissue Proteins; D017923:Sodium-Hydrogen Exchangers; D018698:Glutamic Acid; D000584:Amiloride; D012964:Sodium; D011188:Potassium