Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.
Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed by myo-inositol, rats were pretreated with intracerebroventricular (ICV) injections of myoinositol, artificial CSF or L-chiro-inositol. Lithium chloride, 3 meq/kg was administered intraperitoneally 20-24 h prior to the subcutaneous injection of pilocarpine, 20 or 30 mg/kg. In both experiments, myo-inositol significantly prolonged the latency to the appearance of clonic seizures and lowered the pilocarpine seizure score. myo-Inositol prevented the development of clonic seizures in 50% of the rats receiving pilocarpine, 20 mg/kg. The levels of cortical myo-inositol in rats injected with myo-inositol were approximately double those of the CSF and L-chiro-inositol groups.
Kofman
O
O
Ida and Solomon Stern Psychiatry Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel.
Sherman
W R
WR
Katz
V
V
Belmaker
R H
RH
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced / Q000517:prevention & control; D007276:Injections, Intraventricular; D007294:Inositol / Q000378:metabolism* / Q000494:pharmacology*; D008094:Lithium / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D010862:Pilocarpine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D010862:Pilocarpine; D007294:Inositol; D008094:Lithium