Short-term course of renal function in accelerated hypertension.
Thirty-four patients with primary accelerated hypertension were studied regarding the effect of BP on renal function and the association between fundal grade and renal function before treatment; and the changes in renal function on normalization of BP in 12 patients. Mean arterial pressure was negatively correlated with serum creatinine (r = -0.44, P < 0.02) and there was no significant difference in serum creatinine or in the occurrence of renal failure between patients with grade III (n = 21) and grade IV (n = 13) retinopathy, (P = n.s. and X2 = 0.172 P = n.s. respectively). Twenty-two patients required dialysis at presentation. Serum creatinine rose in 12 other patients on reduction of BP; 7 patients with serum creatinine level < or = 3.2 mg/dL (283 umol/L) at presentation never required dialysis in the 3 months following reduction of BP while those with levels > or = 3.6 mg/dL (319 umol/L) did. In accelerated hypertension, renal function is partly maintained by the blood pressure and dialysis may be required soon after presentation or normalization of BP.
Kadiri
S
S
Department of Medicine, University College Hospital, Ibadan, Nigeria.
Olutade
B O
BO
D001794:Blood Pressure; D003404:Creatinine / Q000097:blood*; D006801:Humans; D006974:Hypertension, Malignant / Q000145:classification / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D015994:Incidence; D007677:Kidney Function Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D051437:Renal Insufficiency / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D017582:Renal Replacement Therapy; D012720:Severity of Illness Index
D003404:Creatinine