Synthesis of pyridylethenyl derivatives of 3H-pyrido[2,3-d]-pyrimidyn-4-on of expected depressive activity on central nervous system. Part I.
Synthesis of 2-(pyridylethenyl) derivatives of 3H-pyrido[2,3-d]pyrimidin-4-on [Va-k] by condensation of selected 2-methyl-3H-pyrido[2,3-d]pyrimidin-4-ones [IVa-k] with nicotinic aldehyde is described. Compounds [Vh] and [Vi] showed weak analgetic activities.
Herold
F
F
Department of Drug Technology, School of Medicine, Warsaw, Poland.
Gutkowska
B
B
Baranowski
A
A
Kałucka
M
M
Helbin
E
E
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000700:Analgesics; D011743:Pyrimidines