The protective role of pyridine N-oxide in cytotoxicity and genotoxicity of hydrogen peroxide and adriamycin.
Scavenging and cytotoxic activity of pyridine N-oxide was investigated in cultured V3 and CHO cells. Pyridine N-oxide was effective in suppressing the cytotoxic effects induced in these systems both by hydrogen peroxide and adriamycin and preventing the production of chromosomal aberrations by these compounds. On the other hand superoxide dismutase inhibited the cytotoxic activity of pyridine N-oxide.
Anuszewska
E
E
Drug Institute, Warsaw, Poland.
Koziorowska
J
J
Wójtowicz
M
M
D000818:Animals; D016466:CHO Cells; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D002869:Chromosome Aberrations; D006224:Cricetinae; D004317:Doxorubicin / Q000633:toxicity*; D006861:Hydrogen Peroxide / Q000633:toxicity*; D011725:Pyridines / Q000494:pharmacology*
D011725:Pyridines; D004317:Doxorubicin; C013229:pyridine N-oxide; D006861:Hydrogen Peroxide