title: A dysbalanced immune system in cryptogenic Lennox-Gastaut syndrome.
abstract: In children with cryptogenic Lennox-Gastaut syndrome we found a functionally impaired humoral immune response to a primary antigen (haemocyanin), despite signs of a triggered immune system consisting of elevated IgG concentrations. This combination of immunological findings, considered to be the expression of a dysbalanced-triggered as well as functionally impaired-immune system, has also been described in an auto-immune disease like systemic lupus erythaematodes in humans, and in genetically epilepsy-prone rats. The interactions between the immune system and the nervous system in Lennox-Gastaut syndrome will be discussed.
authors.affiliation: Department of Paediatrics, University Hospital, Nijmegen, The Netherlands.
authors.forename: B G
authors.initials: BG
authors.lastname: van Engelen
authors.forename: C M
authors.initials: CM
authors.lastname: Weemaes
authors.forename: W O
authors.initials: WO
authors.lastname: Renier
authors.forename: J A
authors.initials: JA
authors.lastname: Bakkeren
authors.forename: G F
authors.initials: GF
authors.lastname: Borm
authors.forename: P F
authors.initials: PF
authors.lastname: Strengers
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004832:Epilepsy, Absence / Q000276:immunology*; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007132:Immunoglobulin Isotypes / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008297:Male; D013577:Syndrome
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M; D006433:Hemocyanins