99mTc-complexes of a pentadentate amine-oxime ligand.
Synthesis and characterization of a new pentadentate amine-oxime ligand, 3,3,11,11-tetramethyl-7-benzyl-4,7,10-triazatridecane-2,12- dionedioxime is reported. The technetium complexes of this ligand was formed by direct reduction of TcO4- in the presence of the ligand at pH 9. The radiochemical yield of the complex is greater than 95% with 10(-7) M 99TcO4-. The technetium complex formed is a positively charged chelate that elutes as a single peak on a reverse phase HPLC. Biodistribution studies in rats showed an uptake of 1.4% of the injected activity at 15 sec p.i. in heart, but the wash-out was fast. The high radiochemical purity and stability of this 99mTc-chelate indicate that these types of chelates hold potential for development of bifunctional chelating agents (BFCAs).
Pillai
M R
MR
Isotope Division, Bhabha Atomic Research Center, Bombay, India.
John
C S
CS
Lo
J M
JM
Troutner
D E
DE
Corlija
M
M
Volkert
W A
WA
Holmes
R A
RA
D000818:Animals; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011868:Radioisotopes / Q000737:chemistry* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
C092287:3,3,11,11-tetramethyl-7-benzyl-4,7,10-triazatridecane-2,12-dionedioxime; D008024:Ligands; D011073:Polyamines; D011868:Radioisotopes