title: Chemotherapeutic treatments involving drug resistance and level of normal cells as a criterion of toxicity.
abstract: A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. Drug resistance and toxicity conveyed through the level of normal cells are taken into account in a class of optimal control problems. Alternative treatments for the exponential tumor growth are set forth for cases where optimal treatments are not available.
authors.affiliation: Laboratório Nacional de Computação Científica-CNPq, R. Lauro Müller, Rio de Janeiro-RJ-Brasil.
authors.forename: M I
authors.initials: MI
authors.lastname: Costa
authors.forename: J L
authors.initials: JL
authors.lastname: Boldrini
authors.forename: R C
authors.initials: RC
authors.lastname: Bassanezi
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004351:Drug Resistance; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents