Oxidative DNA damage induced by Cu(II)-oligopeptide complexes and hydrogen peroxide.
At physiological pH values, Cu(II)-tetraglycine and Cu(II) complexes with peptides containing a histidyl residue at the N-terminal caused DNA strand breakage in the presence of H2O2, whereas Cu(II) complexes with peptides containing histidyl residue in the second or third position did not. Because of the correlation between the generation of hydroxyl radical and DNA strand scission, a mechanism for the reaction is proposed.
Ueda
J
J
National Institute of Radiological Sciences, Chiba-shi, Japan.
Shimazu
Y
Y
Ozawa
T
T
D000595:Amino Acid Sequence; D003300:Copper / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects*; D006639:Histidine; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
D009842:Oligopeptides; D006639:Histidine; D003300:Copper; D006861:Hydrogen Peroxide; C046274:glycyl-glycyl-glycyl-glycine