title: Laboratory assessment of thrombolytic therapy in acute myocardial infarction.
abstract: Hemostatic profiles and cardiac enzymes were studied in 55 acute myocardial infarct (AMI) patients to assess SK and rt-PA therapy. Hypofibrinogenemia occurred 85% in SK group and 55% in rt-PA group with high FDP and D-Dimer, indicating systemic fibrinogenolysis and local crosslinked fibrin clot lysis. The incidence of bleeding in SK and rt-PA groups combined with anticoagulants were the same but lower in rt-PA with antiplatelet. The mean FDP was significantly higher in the bleeding group (p < 0.01). Cardiac enzymes: CK, CK-MB peak values indicated reperfusion were 26.6%, 60% and 90% in conventional, SK and rt-PA therapy, respectively. Early and late occlusion did not occur either in SK or rt-PA followed by anticoagulants. Late occlusion was found in patients treated with rt-PA and antiplatelet. Mortality rate was 20% in conventional therapy.
authors.affiliation: Department of Clinical Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Talalak
authors.forename: S
authors.initials: S
authors.lastname: Chaithiraphan
authors.forename: N
authors.initials: N
authors.lastname: Opartkiattikul
authors.forename: W
authors.initials: W
authors.lastname: Leowattana
authors.forename: W
authors.initials: W
authors.lastname: Sangtawesin
authors.forename: D
authors.initials: D
authors.lastname: Tresukosol
mesh_terms: D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001780:Blood Coagulation Tests; D004176:Dipyridamole / Q000627:therapeutic use; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D013300:Streptokinase / Q000627:therapeutic use*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D014859:Warfarin; D004176:Dipyridamole; D006493:Heparin; D013300:Streptokinase; D010959:Tissue Plasminogen Activator