Effects of fepradinol on rat acute models of vascular permeability and leucocyte migration.
The antiinflammatory compound fepradinol has been tested in several experimental models of acute inflammation in rats. On the increased vascular permeability in the skin, fepradinol (25 mg/kg p.o.) was the only compound that inhibited the inflammatory actions induced by the three chemical mediators injected (histamine, serotonin and bradykinin). On the carrageenin-induced pleurisy, fepradinol (100 mg/kg p.o.) was more potent than indomethacin (5 mg/kg p.o.) and similar to piroxicam (5 mg/kg p.o.) in reducing the exudate volume and preventing cell migration. On the zymosan-induced peritonitis, while the activity of indomethacin (10 mg/kg p.o.) and cyproheptadine was observed only 3 h after zymosan challenge, the response of fepradinol developed within 30 min, suggesting that fepradinol inhibits both the early and late phases of the exudative response. These findings indicate that fepradinol may act on acute inflammation by reducing vascular permeability.
Masso
J M
JM
Department of Pharmacology, ELMU-QUIMICA FARMACEUTICA S.L., Madrid, Spain.
Villar
A M
AM
Conde
J R
JR
Martorell
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D002351:Carrageenan; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D016207:Cytokines / Q000494:pharmacology; D004983:Ethanolamines / Q000494:pharmacology*; D005122:Exudates and Transudates / Q000166:cytology / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010538:Peritonitis / Q000139:chemically induced / Q000473:pathology; D010894:Piroxicam / Q000494:pharmacology; D010998:Pleurisy / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D004983:Ethanolamines; D010894:Piroxicam; C078462:fepradinol; D002351:Carrageenan; D007213:Indomethacin