GAPs for rho-related GTPases.
Ras-related GTP-binding proteins (GTPases) of the rho subfamily play important roles in regulating the organization of the actin cytoskeleton. A large number of multifunctional proteins that can stimulate their intrinsic GTPase activity have been identified. Here, we discuss the nature of such GTPase-activating proteins (GAPs) and their potential importance for cell signalling.
Lamarche
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MRC Laboratory for Molecular Cell Biology, University College London, UK.
Hall
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A
D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism; D004330:Drosophila / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D006801:Humans; D008322:Mammals; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D020690:GTPase-Activating Proteins; C085379:rho GTPase-activating protein; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins