title: High risk genotypes for celiac disease.
abstract: It is known that celiac disease is strongly associated with an HLA class II component and that most patients carry the dimer DQA1*0501, DQB1*0201. We show in this study that the risk for a carrier of this heterodimer is independent from the number of possible heterodimers, from whether DQA1*0501 and DQB1*0201 are in cis or trans position and from the number of DQA1*0501 (one or two) but strongly depends on the number of DQB1*0201. In the Tunisian population we studied, the risk of developing celiac disease is estimated to be 6.8 times greater for those having a double dose of DQB1*0201 than for other dimer carriers. We replicated this result in published data of four other populations (Italy, Czekoslovakia, United Kingdom, Norway).
authors.affiliation: Unité de Recherches d'Epidémiologie Génétique, Institut National de la Santé et de la Recherche Médicale U155, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Clerget-Darpoux
authors.forename: F
authors.initials: F
authors.lastname: Bouguerra
authors.forename: R
authors.initials: R
authors.lastname: Kastally
authors.forename: G
authors.initials: G
authors.lastname: Semana
authors.forename: M C
authors.initials: MC
authors.lastname: Babron
authors.forename: A
authors.initials: A
authors.lastname: Debbabi
authors.forename: B
authors.initials: B
authors.lastname: Bennaceur
authors.forename: J F
authors.initials: JF
authors.lastname: Eliaou
mesh_terms: D000293:Adolescent; D000483:Alleles; D002446:Celiac Disease / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors
chemical_list: D006683:HLA-DQ Antigens