title: Sneddon's syndrome: clinical and immunohistochemical findings.
abstract: Results of immunological studies on skin biopsies of 5 patients with Sneddon's syndrome are reported. Also studied were coagulation factors and autoantibodies believed to play a role in this syndrome. Hemostasis was normal except for a mild increase of fibrinogen in one subject; lupus anticoagulant (LAC) and anticardiolipin antibodies were negative in all. The skin biopsies ruled out systemic vasculitis and vasculitis in association with connective tissue diseases. Sneddon's syndrome is a peculiar clinicopathological condition, probably with several etiologies, but is distinct from primary antiphospholipid syndrome.
authors.affiliation: Istituto Nazionale Neurologico C. Besta, Milan, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Fetoni
authors.forename: E
authors.initials: E
authors.lastname: Berti
authors.forename: E
authors.initials: E
authors.lastname: Cecca
authors.forename: F
authors.initials: F
authors.lastname: Carella
authors.forename: R A
authors.initials: RA
authors.lastname: Sinico
authors.forename: F
authors.initials: F
authors.lastname: Girotti
mesh_terms: D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000235:genetics / Q000276:immunology / Q000473:pathology; D001323:Autoantibodies / Q000032:analysis*; D001706:Biopsy; D001779:Blood Coagulation Factors / Q000032:analysis*; D002545:Brain Ischemia / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis; D008875:Middle Aged; D012867:Skin / Q000276:immunology / Q000473:pathology*; D017445:Skin Diseases, Vascular / Q000235:genetics / Q000276:immunology / Q000473:pathology*
chemical_list: D017153:Antibodies, Anticardiolipin; D001323:Autoantibodies; D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor