Hemoglobinopathies: three illustrative case studies.
Three cases studies from the Regional Hemoglobinopathy Laboratory at St. Joseph's Hospital in Hamilton are presented. These cases demonstrate the diagnostic value of a comprehensive hemoglobinopathy screen, family studies, and appropriate clinical information in solving complex hemoglobinopathy problems. The first case is a 79-year-old woman found to have small amounts of an unknown hemoglobin migrating electrophoretically in the position of hemoglobin S. The second case describes a boy of Greek extraction with a thalassemic blood picture but otherwise normal hemoglobinopathy screen. The third case involves a 70-year-old man with a previously normal hemoglobinopathy screen who subsequently showed evidence of alpha thalassemia.
Wang
J C
JC
Department of Laboratory Medicine, St. Joseph's Hospital, Hamilton, Ontario.
Lafferty
J
J
Ali
M
M
D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006453:Hemoglobinopathies / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree