Serotonin-induced platelet intracellular calcium mobilization in depressed patients.
Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancholic major depression and normal controls. The enhanced Ca response to 5-HT failed to correlate with severity of depressive symptoms. In patients with bipolar disorder and melancholic major depression, there was no significant difference in 5-HT-stimulated Ca response between the unmedicated group and those in remission. These results suggest that 5-HT2 receptor function is increased in some types of depression, and raise the possibility that the enhanced Ca response to 5-HT may be trait dependent rather than state dependent.
Kusumi
I
I
Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, Japan.
Koyama
T
T
Yamashita
I
I
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000523:psychology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D002118:Calcium