Sinusoidal embolization: impact of iodized oil on hepatic microcirculation.
OBJECTIVE
To determine the effects of iodized oil, which is used in chemoembolization of liver cancer, on hepatic microcirculation and to measure the time required for recovery of microcirculation.


METHODS
Iodized oil was injected in 0.1-, 0.2-, and 0.4-mL/kg doses into the hepatic artery in three groups of rats (n = 63). In vivo microscopy was performed during and immediately after the procedure and on days 1, 3, 7, 15, 30, and 60. A control group of rats underwent identical microscopy procedures.


RESULTS
Changes in microcirculation occurred after injections with iodized oil. Oil injected into the hepatic artery entered the portal vein and flowed into the sinusoids to create an incomplete sinusoidal embolization. Recovery of the sinusoidal circulation occurred 3, 7, and 30 days after injections of 0.1, 0.2, and 0.4 mL/kg of oil, respectively.


CONCLUSIONS
The liver tolerated oil embolization well. Despite the changes in microcirculation and a nonlinear recovery time, the microcirculation completely recovered, even with a 0.4-mL/kg dose.
Kan
Z
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Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Wallace
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D000818:Animals; D004621:Embolization, Therapeutic; D006499:Hepatic Artery; D007459:Iodized Oil / Q000008:administration & dosage*; D008102:Liver Circulation; D008833:Microcirculation; D008852:Microradiography; D051381:Rats; D011916:Rats, Inbred F344
D007459:Iodized Oil