title: Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D.
abstract: Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis.
authors.affiliation: Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
authors.forename: X H
authors.initials: XH
authors.lastname: Huang
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: H
authors.initials: H
authors.lastname: Tomoda
authors.forename: N
authors.initials: N
authors.lastname: Tabata
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: D J
authors.initials: DJ
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Takayanagi
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry / Q000378:metabolism; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D011522:Protons; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
chemical_list: D000900:Anti-Bacterial Agents; D002247:Carbon Isotopes; D004224:Diterpenes; D007211:Indoles; D011522:Protons; C092161:terpendole A; C092162:terpendole B; C092163:terpendole C; C092164:terpendole D; D002785:Sterol O-Acyltransferase