Release of endogenous ATP from the caudal artery in rats with arteriosclerosis.
Noradrenaline significantly increased (by a prazosin-sensitive mechanism) the overflow of ATP and its metabolites from the caudal arteries of rats treated with excess vitamin D2 and a high-cholesterol diet (arteriosclerotic rats), although the amount of the overflow was smaller than that in the normal rats. The arteries from the arteriosclerotic rats showed a marked increase in the calcium content and there was a significant negative correlation between the noradrenaline-induced overflow of ATP and the arterial calcium content. These findings indicate that ATP release from arteriosclerotic rat caudal arteries mediated by alpha 1-adrenoceptors is impaired in proportion to the extent of arterial calcification.
Shinozuka
K
K
Department of Pharmacology, Shimane Medical University, Izumo, Japan.
Kitagawa
S
S
Kunitomo
M
M
Yamaguchi
Y
Y
Tanabe
Y
Y
Fujiwara
M
M
Hattori
K
K
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001158:Arteries / Q000378:metabolism* / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000378:metabolism / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism / Q000648:ultrastructure; D004872:Ergocalciferols / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology
D002791:Cholesterol, Dietary; D004872:Ergocalciferols; D018340:Receptors, Adrenergic, alpha-1; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D002118:Calcium; D009638:Norepinephrine