Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis.
Exposure of agricultural workers and the general population to pesticides is a major concern, and possible summation or synergistic effects deserves particular attention. In this study, however, combined dietary administration of 19 organophosphorus compounds and one organochlorine pesticide, each at acceptable daily intake (ADI) levels, did not enhance rat liver preneoplastic lesion development initiated by diethylnitrosamine. In contrast, a mixture of 100 times ADI significantly increased the number and area of lesions. The results thus provide direct support for the present safety factor approach to the quantitative hazard evaluation of pesticides.
Ito
N
N
First Department of Pathology, Nagoya City University Medical School, Japan.
Hasegawa
R
R
Imaida
K
K
Kurata
Y
Y
Hagiwara
A
A
Shirai
T
T
D000284:Administration, Oral; D000382:Agricultural Workers' Diseases / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004052:Diethylnitrosamine / Q000633:toxicity; D004195:Disease Models, Animal; D004357:Drug Synergism; D005982:Glutathione Transferase / Q000378:metabolism; D006498:Hepatectomy; D007091:Image Processing, Computer-Assisted; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D016273:Occupational Exposure; D009929:Organ Size / Q000187:drug effects; D009943:Organophosphorus Compounds; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship; D014944:World Health Organization
D007306:Insecticides; D009943:Organophosphorus Compounds; D004052:Diethylnitrosamine; D005982:Glutathione Transferase