[The neurochemical mechanisms of the central amygdaloid nucleus and the anxiolytic action of tranquilizers in different models of anxiety states].
Chemical stimulation of the central nucleus of the amygdalar complex was carried out in rats during performance of tests of avoidance of "lighted square" and "threatening situation". Microinjections of monoamines, GABA, glutamate, some of their receptor agonists and antagonists revealed neurochemical heterogeneity of the structure and functional ambiguity of neurotransmitter systems in genesis of anxiety of different aversive modes. Chlordiazepoxid, phenibut, indoter, campiron, campironin decrease anxiety in the tests of avoidance of "lighted square" and "threatening situation", their effects being similar to those of dopamine, GABA, or serotonin. A conclusion is made that distinctions in spectra of anxiosedative and anxioselective drugs under study may be caused by unequal contribution of monoamine and amino acid transmitter mechanisms of the central region of the amygdalar complex in genesis of heteromodal aversive anxiety.
Talalaenko
A N
AN
Krivobok
G K
GK
Babiĭ
Iu V
IuV
Bogdanov
V A
VA
Perch
N N
NN
D000679:Amygdala / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001007:Anxiety / Q000209:etiology / Q000503:physiopathology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D008297:Male; D008845:Microinjections; D051381:Rats
D014151:Anti-Anxiety Agents
Neĭrokhimicheskie mekhanizmy tsentral'nogo iadra mindalevidnogo kompleksa i anksioliticheskoe deĭstvie trankvilizatorov v razlichnykh modeliakh trevozhnykh sostoianiĭ.