The cation-independent mannose-6-phosphate receptor binds to soluble GPI-linked proteins via mannose-6-phosphate.
The cation-independent mannose-6-phosphate/insulin-like growth factor II receptor has been observed to bind to soluble forms of glycosyl-phosphatidylinositol-linked molecules, one of mammalian origin (rat Thy-1) and two of protozoan origins. Of the two phosphate groups found on the soluble forms of the protozoan glycosyl-phosphatidylinositol-linked molecules: (i) the internal mannose-6-phosphate diester (which forms a part of the ethanolamine bridge) and (ii) the inositol-1,2 cyclic phosphate group (which arises after cleavage of the membrane associated form with phosphatidylinositol-specific phospholipase C), only the former appears to be recognized by the mannose-6-phosphate/insulin-like growth factor II receptor, as mild acid hydrolysis which destroys the latter has been observed not to affect the receptor binding site.
Green
P J
PJ
Glycosciences Laboratory, Northwick Park Hospital, Middx, UK.
Ferguson
M A
MA
Robinson
P J
PJ
Feizi
T
T
D000818:Animals; D001665:Binding Sites; D002240:Carbohydrate Sequence; D002412:Cations; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D008360:Mannosephosphates / Q000378:metabolism*; D008969:Molecular Sequence Data; D051381:Rats; D017527:Receptor, IGF Type 2 / Q000378:metabolism*; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000378:metabolism*
D002412:Cations; D017261:Glycosylphosphatidylinositols; D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; D014643:Variant Surface Glycoproteins, Trypanosoma; C027693:mannose-6-phosphate