title: Enhancement of intestinal absorptive capacity with omental flaps.
abstract: The ability of pedicled omental flaps to revascularize isolated jejunal segments was determined in the initial phase of this project. These bowel segments were capable of surviving independent of their mesenteric perfusion, and absorptive function was equal to that of controls as measured by D-xylose assays. In the second phase of this research, we studied in 10 dogs the absorptive capacity of isolated jejunal segments with both an intact mesentery and an omental flap sutured to the antimesenteric border compared with controls that were perfused only by the mesentery. Absorption was measured at 1, 2, 5, and 10 weeks after application of the omental flap. Absorptive function was augmented an average of 25.8% at 2 weeks, reaching 67.6% (p < 0.001) at 5 weeks. This result remained consistent at 10 weeks. Laser Doppler and colored microsphere studies were performed during a secondary laparotomy at 10 weeks and revealed 42.3% and 53.5% increases, respectively, in blood flow to bowel segments receiving both mesenteric and omental perfusion. This finding suggested that the augmentation of absorptive function was a result of increased blood flow.
authors.affiliation: Department of Surgery, University of Washington, Seattle 98195.
authors.forename: R P
authors.initials: RP
authors.lastname: Rand
authors.forename: A
authors.initials: A
authors.lastname: Amerhauser
authors.forename: A
authors.initials: A
authors.lastname: Justicz
authors.forename: M J
authors.initials: MJ
authors.lastname: Jurkiewicz
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D004285:Dogs; D005260:Female; D007408:Intestinal Absorption; D007583:Jejunum / Q000098:blood supply / Q000378:metabolism / Q000601:surgery*; D017078:Laser-Doppler Flowmetry; D009852:Omentum / Q000098:blood supply / Q000637:transplantation; D013524:Surgical Flaps; D014994:Xylose / Q000378:metabolism
chemical_list: D014994:Xylose