title: The effect of 1 beta-methyl substituent and the basicity in C-2 side chain in carbapenem antibiotics on the activity against Pseudomonas aeruginosa oprD2 and nalB mutants.
authors.affiliation: Sumitomo Pharmaceuticals Research Center, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sumita
authors.forename: H
authors.initials: H
authors.lastname: Yamaga
authors.forename: M
authors.initials: M
authors.lastname: Sunagawa
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006863:Hydrogen-Ion Concentration; D009154:Mutation; D018272:Porins / Q000235:genetics*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; C082923:OprD2 protein, Pseudomonas aeruginosa; D018272:Porins