Arthritis after hepatitis B vaccination. Report of three cases.
Side effects of hepatitis vaccination are rare. Only a few cases of arthritis after hepatitis vaccination have been published. We report on three cases of vaccination-induced arthritis with different resulting disease. Two cases show the pattern of reactive arthritis. None of them was associated with HLA-B27. In the third case onset of rheumatoid arthritis was triggered by hepatitis vaccination. These three cases show that arthritis after hepatitis B vaccination probably is more common than reported so far, especially in a genetically predisposed subject (two of our patients expressed HLA-DR4).
Gross
K
K
Rheumatology Unit, LM University of Munich, Germany.
Combe
C
C
Krüger
K
K
Schattenkirchner
M
M
D000293:Adolescent; D000328:Adult; D016918:Arthritis, Reactive / Q000150:complications / Q000209:etiology* / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000209:etiology* / Q000276:immunology; D005260:Female; D015804:HLA-DR4 Antigen / Q000032:analysis; D006282:Health Personnel; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans
D015804:HLA-DR4 Antigen; D017325:Hepatitis B Vaccines