Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.
The use of antiepileptic agents for individuals with learning disabilities (mental handicap) resident both within National Health Service facilities and the community was surveyed in the UK. There was no difference in rates of polypharmacy, but there were significant differences in choice of antiepileptic agent. In particular, individuals resident in the community were more likely to be in receipt of phenytoin, primidone and phenobarbitone, which are particularly recognized as producing adverse effects on cognition and behaviour.
Branford
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D
Glenfrith Unit, Leicester, England.
Collacott
R A
RA
D000328:Adult; D000553:Ambulatory Care; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D003072:Cognition Disorders / Q000139:chemically induced* / Q000523:psychology; D003631:Day Care, Medical; D004359:Drug Therapy, Combination; D004363:Drug Utilization; D004739:England; D004827:Epilepsy / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D007326:Institutionalization; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D007360:Intelligence / Q000187:drug effects; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects / Q000627:therapeutic use; D010672:Phenytoin / Q000009:adverse effects / Q000627:therapeutic use; D011324:Primidone / Q000009:adverse effects / Q000627:therapeutic use; D012919:Social Behavior; D013222:State Medicine
D000927:Anticonvulsants; D011324:Primidone; D010672:Phenytoin; D010634:Phenobarbital