title: Rapid nuclear actions of growth hormone.
abstract: The mechanisms by which growth hormone (GH) initiates its effect on growth are largely unknown. In this report we examine the acute actions of GH with a focus on the intracellular signaling pathways leading from the cell-surface GH receptor into the nucleus, and culminating in the activation of specific target genes. We show that in vivo GH treatment leads to the rapid appearance of tyrosine-phosphorylated nuclear proteins and the equally rapid induction of c-fos and insulin-like growth factor I gene transcription. A model is proposed for a GH-activated intracellular signal transduction pathway.
authors.affiliation: Department of Medicine and Biochemistry, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: P
authors.initials: P
authors.lastname: Rotwein
authors.forename: A M
authors.initials: AM
authors.lastname: Gronowski
authors.forename: M J
authors.initials: MJ
authors.lastname: Thomas
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D013006:Growth Hormone / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D011986:Receptors, Somatotropin / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D009687:Nuclear Proteins; D011986:Receptors, Somatotropin; D013006:Growth Hormone