Is trisomy 4 a secondary chromosomal abnormality in acute myeloblastic leukemia?
Cytogenetic studies were carried out in a patient with acute monocytic leukemia (AML-M5) at diagnosis and in relapse. While no chromosome abnormality was detected initially, isolated trisomy 4 was found in relapse. The primary or secondary nature of trisomy 4 as the sole abnormality in AML is discussed.
Bonomi
R
R
INSERM Unité 301, Institut de Génétique Moléculaire, Paris, France.
Le Coniat
M
M
Berger
R
R
D000328:Adult; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014314:Trisomy / Q000235:genetics*