Alpha-tocopherol mediated peroxidation in the copper (II) and met myoglobin induced oxidation of human low density lipoprotein: the influence of lipid hydroperoxides.
The principal antioxidant in human LDL, alpha-tocopherol, is converted to the alpha-tocopheroxyl radical after reaction with peroxyl radicals or Cu2+, and, if it does not terminate with peroxyl radicals, could initiate lipid peroxidation; a phenomenon called 'tocopherol mediated peroxidation'. Only in the presence of Cu2+ and low levels of lipid hydroperoxides was an alpha-tocopherol dependent decrease in the resistance of LDL to oxidation detected. This suggests that tocopherol mediated peroxidation will probably not contribute significantly as a pro-oxidant process in those individuals most at risk of developing atherosclerosis through an oxidative mechanism.
Iwatsuki
M
M
Research Centre for Advanced Science and Technology, University of Tokyo, Japan.
Niki
E
E
Stone
D
D
Darley-Usmar
V M
VM
D001393:Azoles / Q000737:chemistry; D002413:Cations, Divalent; D003300:Copper / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D054833:Isoindoles; D008054:Lipid Peroxides / Q000737:chemistry*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008786:Metmyoglobin / Q000737:chemistry*; D016566:Organoselenium Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000494:pharmacology*
D001393:Azoles; D002413:Cations, Divalent; D054833:Isoindoles; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D016566:Organoselenium Compounds; D008786:Metmyoglobin; D014810:Vitamin E; C042986:ebselen; D003300:Copper