Construction of human Y-chromosomal haplotypes using a new polymorphic A to G transition.
We report the discovery of a polymorphic A to G transition found on the human Y chromosome by sequencing Y-specific sequence-tagged sites (STSs). It shows maximal linkage disequilibrium with a previously described Alu insertional polymorphism. We analyze further an apparently African Y chromosome which seems to have entered a Mexican Mayan population several generations ago. Using the newly discovered transition and the Y-specific polymorphic Alu insertion, we discuss how the chromosome's haplotype information might be used to answer questions of human origins and migrations.
Seielstad
M T
MT
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.
Hebert
J M
JM
Lin
A A
AA
Underhill
P A
PA
Ibrahim
M
M
Vollrath
D
D
Cavalli-Sforza
L L
LL
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods; D004251:DNA Transposable Elements / Q000235:genetics; D006071:Gorilla gorilla; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D002679:Pan troglodytes; D017354:Point Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics; D016324:Sequence Tagged Sites; D014998:Y Chromosome / Q000235:genetics*
D004251:DNA Transposable Elements