Effect of misoprostol on the enzyme ontogeny of the rat intestine.
The effect of Misoprostol (an analog of PGE1) on the biochemical changes in the small intestine of suckling rats was studied. Misoprostol increases sucrase activities in the proximal and the distal small intestine. Jejunal aminopeptidase N activity is higher in Misoprostol-treated rats than in the control rats. This drug also modifies the relative weight of the small intestine and the mucosal ratio of DNA to RNA. Misoprostol effects appear to be mediated by corticosterone release.
Marti
A
A
Department of Physiology and Nutrition, School of Pharmacy, University of Navarra, Pamplona, Spain.
Moreno
M J
MJ
Fernandez-Otero
M P
MP
D000818:Animals; D000833:Animals, Suckling; D018826:CD13 Antigens / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D007421:Intestine, Small / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism; D008297:Male; D016595:Misoprostol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013393:Sucrase / Q000378:metabolism
D016595:Misoprostol; D013393:Sucrase; D018826:CD13 Antigens; D003345:Corticosterone