title: Treatment of cryptococcal meningitis with combination itraconazole and flucytosine.
abstract: The results of an open study of the efficacy of itraconazole and flucytosine in 10 patients with cryptococcal meningitis are reported. The outcome revealed eight responding cases (cure in 4 cases and improvement in 4 cases), and two failure cases. One patient had a relapse which responded to amphotericin B and flucytosine. No toxicity was observed.
authors.affiliation: Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand.
authors.forename: V
authors.initials: V
authors.lastname: Chotmongkol
authors.forename: S
authors.initials: S
authors.lastname: Jitpimolmard
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D017964:Itraconazole; D005437:Flucytosine