title: Cyclosporine A, an alternative to the oral lichen planus erosive treatment.
abstract: We present a double-blind study in two groups afflicted with oral lichen planus erythematous of long evolution and resistant to other treatments. We tested on it a treatment with Cyclosporine A (CyA) which had been successfully used before by many dermatologists. In the group A we used mouthwashes with a 5 ml Cyclosporine A solution to a 10% in olive oil of 0.4 degrees of acidity for five minutes, three times a day for eight weeks. In the control group we used acetonide of triamcinolone 01% in aqueous solution. Patients in group A improved considerably in their symptomatology in a 90% against a 60% in group B. In group A we could appreciate a disappearance of the symptomatology after two weeks of treatment in 60% of patients against 30% in group B. CyA can be an alternative to the conventional treatments in the acute period of lichen planus although it can not be considered as a first option drug because of the high cost of the treatment. For long term, results are not so good and we consider that extensive studies are necessary.
authors.affiliation: Department of Oral Medicine, Dental School, University of Barcelona.
authors.forename: J
authors.initials: J
authors.lastname: López López
authors.forename: X
authors.initials: X
authors.lastname: Roselló Llabrés
mesh_terms: D000208:Acute Disease; D016572:Cyclosporine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D017676:Lichen Planus, Oral / Q000188:drug therapy* / Q000473:pathology; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D009067:Mouthwashes; D012074:Remission Induction; D013997:Time Factors
chemical_list: D009067:Mouthwashes; D016572:Cyclosporine