title: Detection of clenbuterol residues in hair.
abstract: Sixty rats were grown in the presence of 10 (n = 30) and 100 (n = 30) micrograms kg-1 body mass of clenbuterol for a period of 10 d. An immunoextraction step coupled with a competitive enzyme immunoassay allowed the quantification of clenbuterol in hair upon 20 (10 micrograms kg-1) and 30 d (10 micrograms kg-1) after the last dose. This accumulation in hair contrasts with the rapid clearance in tissues. The nature of the immunoreactive material was confirmed by mass spectrometry.
authors.affiliation: Faculté de Pharmacie, Université de Montréal, Québec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Adam
authors.forename: N
authors.initials: N
authors.lastname: Gervais
authors.forename: A
authors.initials: A
authors.lastname: Panoyan
authors.forename: H
authors.initials: H
authors.lastname: Ong
authors.forename: L
authors.initials: L
authors.lastname: Beliveau
authors.forename: C
authors.initials: C
authors.lastname: Ayotte
authors.forename: P
authors.initials: P
authors.lastname: Delahaut
mesh_terms: D000818:Animals; D002846:Chromatography, Affinity / Q000379:methods; D002976:Clenbuterol / Q000032:analysis* / Q000302:isolation & purification / Q000493:pharmacokinetics; D004350:Drug Residues / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006197:Hair / Q000737:chemistry*; D007124:Immunoenzyme Techniques; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D018482:Muscle, Skeletal / Q000737:chemistry; D051381:Rats; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D002976:Clenbuterol