Inhibition by Guan-mu-tong (Caulis aristolochiae manshuriensis) of the growth of spontaneous mammary tumors in SHN virgin mice.
Multiparous SHN mice with spontaneous mammary tumors (5-10 mm in size) were given water extract of Guan-mu-tong (Gmt; Caulis aristolochiae manshuriensis) (0.5%) ad libitum as drinking water for 10 days. This treatment retarded significantly the growth of mammary tumors compared with the controls. By contrast, normal mammary gland growth, histology of adrenals and ovaries, and body weight were affected little by the Gmt treatment. Gmt appears to be the first agent inhibiting the growth of spontaneous mouse mammary tumors of palpable size by per os treatment.
Wu
G
G
Experimental Animal Research Laboratory, Meiji University, Kawasaki, Japan.
Tsunoda
S
S
Inatomi
H
H
Nagasawa
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001835:Body Weight; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004702:Endocrine Glands / Q000473:pathology; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D016211:Transforming Growth Factor alpha / Q000032:analysis
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D016211:Transforming Growth Factor alpha