The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2.
The genomic structure of Stat2 has been determined and compared with a large portion of the Stat1 gene. There are 24 exons in the Stat2 gene and a matching number in very similar positions in the Stat1 gene. Thus a very complicated genomic structure was presumably duplicated and has been closely maintained throughout evolution.
Yan
R
R
Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.
Qureshi
S
S
Zhong
Z
Z
Wen
Z
Z
Darnell
J E
JE
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D005091:Exons / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D050832:Interferon-Stimulated Gene Factor 3; D050834:Interferon-Stimulated Gene Factor 3, gamma Subunit; D016898:Interferon-alpha / Q000494:pharmacology; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D015183:Restriction Mapping; D050794:STAT1 Transcription Factor; D050795:STAT2 Transcription Factor; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; C494227:IRF9 protein, human; D050832:Interferon-Stimulated Gene Factor 3; D050834:Interferon-Stimulated Gene Factor 3, gamma Subunit; D016898:Interferon-alpha; D011993:Recombinant Fusion Proteins; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D050795:STAT2 Transcription Factor; C494084:STAT2 protein, human; D015534:Trans-Activators; D014157:Transcription Factors