Depression of cytochrome P-450 in mouse liver induced by fractions from Nocardia opaca.
We measured the liver cytochrome P-450 content of mice 24 h after they had been injected with the following immunoadjuvants: Nocardia opaca derivatives and peptidoglycans from several bacterial strains. The cell wall fraction was not active, the others diminished liver cytochrome P-450 levels. The dose-response activity varied with the bacterial origin of the peptidoglycans. These findings indicate that the toxicity and efficiency of immunochemotherapeutic protocols can be modified by altering drug metabolism.
Ocenásková
J
J
Laboratory for Special Medical Microbiology and Immunology, Faculty of Medicine, Charles University, Prague, Czeck Republic.
Mara
M
M
Orbach-Arbouys
S
S
Leclerc
M
M
Barot-Ciorbaru
R
R
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology*; D009615:Nocardia / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System