title: Ameloblastoma with stromal multinucleated giant cells.
abstract: We report a case of ameloblastoma which uniquely showed heavy osteoclast-like giant cell accumulation and woven bone formation in the surrounding fibrous stroma. Immunohistochemistry showed that the giant cells were non-epithelial in origin and suggested that stromal factors (i.e., the presence or absence of mineralized bone) determines whether these cells express an osteoclastic antigenic phenotype.
authors.affiliation: International Nepal Fellowship, Pokhara.
authors.forename: B M
authors.initials: BM
authors.lastname: Richard
authors.forename: M
authors.initials: M
authors.lastname: Thyveetil
authors.forename: H
authors.initials: H
authors.lastname: Sharif
authors.forename: N A
authors.initials: NA
authors.lastname: Athanasou
mesh_terms: D000328:Adult; D000564:Ameloblastoma / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D008441:Maxillary Neoplasms / Q000473:pathology*