[Inhibitory effects of monomer T4 from Tripterygium wilfordii hook on cultured mesangial cells proliferation and IL-1 production].
The cultured mesangial cells (MSc) went through three serial passages before being using. Quantitation of MSc growth rate was obtained by measuring the ratio of 3H-TdR uptake in a medium containing various concentrations of T4. IL-1 activity was tested by 3H-TdR incorporation in C57BL/c mice thymocytes. The results show that T4 inhibited MSc proliferation and IL-1 production.
Zhang
L
L
PUMC Hospital, CAMS, Beijing.
Bi
Z
Z
Li
X
X
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004224:Diterpenes / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005920:Glomerular Mesangium / Q000166:cytology* / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010616:Phenanthrenes
D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D007375:Interleukin-1; D010616:Phenanthrenes; C068051:tripchlorolide