[Free amino acids in fetal urine and prognosis of renal function in bilateral obstructive uropathies].
In order to evaluate renal function, fetal urine was sampled in 27 fetuses with urinary tract obstruction diagnosed by ultrasonography. Amino acid concentrations were measured retrospectively. On histological examination performed after termination of pregnancy, five fetuses were found to have bilateral renal dysplasia (group 1). Eleven fetuses developed renal failure after birth: at one year, plasma creatinine concentration was over 50 mumol/l (group 2). Renal function was normal in the 11 other infants (group 3, plasma creatinine concentration at one year < 50 mumol-1). Statistically significant between-group differences were seen in fetal urine amino acids concentrations. However, there was an overlap of values in the three groups and individual amino acid concentrations could not be used predictively.
Muller
F
F
Biochimie, hôpital Ambroise-Paré, Boulogne, France.
Parvy
P
P
Dommergues
M
M
Lortat-Jacob
S
S
Dumez
Y
Y
Kamoun
P
P
D000596:Amino Acids / Q000652:urine*; D005333:Fetus / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000503:physiopathology*; D011379:Prognosis; D051437:Renal Insufficiency / Q000503:physiopathology / Q000652:urine; D012189:Retrospective Studies; D014551:Urinary Tract / Q000002:abnormalities; D014570:Urologic Diseases / Q000503:physiopathology* / Q000652:urine*
D000596:Amino Acids
Acides aminés libres de l'urine foetale et pronostic de la fonction rénale dans les uropathies obstructives bilatérales.