title: [Brain stem glioma induced by radiotherapy: report of a case].
abstract: A case of brain stem glioma following radiotherapy for brain tumor is presented. A 44-year-old female was admitted with chief complaints of gait disturbance and disturbed consciousness. She had received radiation therapy with 60Gy following resection of a right temporal astrocytoma 20 years before, but until admission this time follow up CT scan had shown no regrowth. On admission CT scan and MRI showed an enhanced mass (2 x 2.5cm) in the mid-brain. Tumor biopsy was performed using the subtemporal approach. The histological diagnosis showed a fibrillary astrocytoma grade III. The patient received postoperative synchronized chemotherapy but expired 8 months after admission. The growth of glioma appeared in the previous radiation field after a long latent period. This case should be considered not as a case of the regrowth of a tumor but as a case of a radiation induced tumor. Although 77 cases of gliomas following radiation for intracranial tumor have been reported, this case of radiation-induced brain stem glioma is extremely rare.
authors.affiliation: Department of Neurosurgery, Toyooka Hospital, Hyogo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tomita
authors.forename: H
authors.initials: H
authors.lastname: Nogaki
authors.forename: Y
authors.initials: Y
authors.lastname: Shibata
authors.forename: N
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy*; D001933:Brain Stem; D016371:Cranial Irradiation / Q000009:adverse effects; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy*; D005910:Glioma / Q000209:etiology*; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D013997:Time Factors