Immunocharacterization of H-2Kb-tsA58 transgenic mouse hippocampal neuroepithelial cells.
From dissected fragments of embryonic H-2Kb-tsA58 transgenic mouse hippocampal neuroepithelium, we have derived a population of rapidly proliferating, nestin-positive conditionally immortal hippocampal neuroepithelial cells. Treatment with dibutyryl cAMP in non-permissive culture conditions resulted in cessation of cell division and differentiation of the precursor cells into neuronal or glial phenotypes.
Kershaw
T R
TR
Neurodegenerative Diseases Research Group, Institute of Psychiatry, De Crespigny Park, London, UK.
Rashid-Doubell
F
F
Sinden
J D
JD
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D004847:Epithelial Cells; D006624:Hippocampus / Q000737:chemistry* / Q000166:cytology; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic