Cholestatic jaundice induced by spontaneous disruption of an oestrogen implant.
OBJECTIVE
To describe the case of a women with cholestatic jaundice induced by the spontaneous fragmentation of an oestrogen implant.


METHODS
A 48-year-old woman, who presented with jaundice, pruritus and a flu-like illness 2 weeks after the insertion of a 100 mg oestradiol implant into her right buttock.


METHODS
At presentation the implant was removed and found to be fragmented. Investigations revealed an oestradiol level of 1548 pmol/l and an oestrogen-induced cholestatic jaundice.


RESULTS
After removal of the implant and progesterone therapy, the patients symptoms resolved.


CONCLUSIONS
This is the first reported case of cholestatic jaundice induced by a subcutaneous oestrogen implant.
Bowling
T E
TE
Department of Gastroenterology, Central Middlesex Hospital, London, UK.
al-Adnani
M
M
Silk
D B
DB
D002779:Cholestasis / Q000139:chemically induced*; D004343:Drug Implants / Q000009:adverse effects; D004868:Equipment Failure; D004958:Estradiol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged
D004343:Drug Implants; D004958:Estradiol