phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila.
phyllopod (phyl) encodes a novel protein required for fate determination of photoreceptors R1, R6, and R7, the last three photoreceptors to be recruited into the ommatidia of the developing Drosophila eye. Genetic data suggests that phyl acts downstream of Ras1, raf, and yan to promote neuronal differentiation in this subset of photoreceptors. Ectopic expression of phyl in the cone cell precursors mimics the effect of ectopic activation of Ras1, suggesting that phyl expression is regulated by Ras1. phyl is also required for embryonic nervous system and sensory bristle development.
Chang
H C
HC
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720-3200.
Solomon
N M
NM
Wassarman
D A
DA
Karim
F D
FD
Therrien
M
M
Rubin
G M
GM
Wolff
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D003001:Cloning, Molecular; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D005123:Eye / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect / Q000235:genetics; D007814:Larva; D008969:Molecular Sequence Data; D009420:Nervous System / Q000196:embryology; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology; D017956:Photoreceptor Cells, Invertebrate / Q000166:cytology*; D017422:Sequence Analysis, DNA; D013489:Suppression, Genetic; D018631:ras Proteins / Q000502:physiology
D029721:Drosophila Proteins; D009687:Nuclear Proteins; C092070:phyl protein, Drosophila; D018631:ras Proteins