title: Combined single course carboplatin with radiotherapy in treatment of stage IIA,B seminoma--a preliminary report.
abstract: Twenty-one patients with Stage IIA or B seminoma have been treated post orchidectomy by a single course of carboplatin prior to conventional radiotherapy in either the Royal Marsden Hospital or the Norwegian Radium Hospital during 1989-1993. Follow-up ranged from 8 months to 51 months with a mean of 36 months and median 34 months. All patients achieved complete remission and remain disease free. The main side-effects were nausea and vomiting while haematological toxicity was slight. There was no symptomatic peripheral neuropathy, ototoxicity or deterioration of renal function. This combined modality approach is rational, feasible, and effective, although a larger number of patients with longer term follow-up are needed for reasonable comparison with the use of infradiaphragmatic radiotherapy alone.
authors.affiliation: Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey, UK.
authors.forename: W Q
authors.initials: WQ
authors.lastname: Yao
authors.forename: S D
authors.initials: SD
authors.lastname: Fosså
authors.forename: D P
authors.initials: DP
authors.lastname: Dearnaley
authors.forename: A
authors.initials: A
authors.lastname: Horwich
mesh_terms: D000328:Adult; D016190:Carboplatin / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000209:etiology; D009367:Neoplasm Staging; D009919:Orchiectomy; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012074:Remission Induction; D018239:Seminoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D014839:Vomiting / Q000139:chemically induced / Q000209:etiology
chemical_list: D016190:Carboplatin