title: Prevention of nausea and vomiting with transdermal hyoscine in adults after middle ear surgery during general anaesthesia.
abstract: In a double-blind, randomized study, we have compared the efficacy of transdermal hyoscine in the prevention of nausea and vomiting with placebo in 60 young, ASA I-II patients after middle ear surgery during general anaesthesia. In the placebo group, 27% and 43% of patients suffered from nausea and vomiting, respectively, during the first 24 h after anaesthesia. The corresponding values for both symptoms in the hyoscine group were 10% (P < 0.001 between groups). The frequency of side effects was similar in both groups. The results suggest that transdermal hyoscine is a useful prophylaxis against nausea and vomiting after middle ear surgery.
authors.affiliation: Department of Anaesthesia, Otolaryngological Hospital, University of Helsinki, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Honkavaara
authors.forename: L
authors.initials: L
authors.lastname: Saarnivaara
authors.forename: U M
authors.initials: UM
authors.lastname: Klemola
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000768:Anesthesia, General; D004311:Double-Blind Method; D004432:Ear, Middle / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D012601:Scopolamine / Q000008:administration & dosage*; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D012601:Scopolamine