title: Regulation by glucose availability of tension development and electrical activity in fetal and neonatal rat hearts.
abstract: The aim of the present article was to study if changes in glucose availability modify the functional activity of the glucose-dependent developing heart. Our data indicate that a decrease in glucose availability increases tension development and action potential duration at early fetal stages. This fact could probably be explained by the enhancement of Ca2+ movements that regulate the number and turnover rate of membrane glucose transporters in muscle cells. The sensitivity to glucose availability decreases postnatally as the heart becomes fatty acid-dependent.
authors.affiliation: Department of Physiology, National Institute of Cardiology Ignacio Chávez, Mexico DF, Mexico.
authors.forename: V
authors.initials: V
authors.lastname: Guarner
authors.forename: E H
authors.initials: EH
authors.lastname: Hernández
authors.forename: S J
authors.initials: SJ
authors.lastname: Moreno
authors.forename: R
authors.initials: R
authors.lastname: Huerto
authors.forename: P
authors.initials: P
authors.lastname: Gorostiza
authors.forename: F
authors.initials: F
authors.lastname: Valenzuela
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D005318:Fetal Heart / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007537:Isometric Contraction / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005947:Glucose