[Phenotyping: personal contribution to research on increased susceptibility of individual HLA phenotype combinations in predisposition to contact allergies].
We determined the A and B locus antigenic phenotype structure by means of the lymphocytotoxic test (Terasaki) in 43 subjects with allergic contact dermatitis verified by the Patch test, as well as in 103 healthy subjects (control group). Statistical fashioning was carried out by counting all of the phenotypes in the group examined by using the 2 x 2 table the X2 test with -correction according to Yates. In a case of an existing difference in frequency, the relative risk (RR) (Svejgaard) was determined. When RR was greater relation with the disease exists with the antigen which was found to have a greater EF value (Bengtsson). A statistically significant increase of A1 antigen frequency and decrease of A28 antigen frequency, as well as the absence of B13 and BW41 antigens in the group examined can be considered as a contribution in clarifying the genetic component in contact allergy etiopathogenesis.
Jovanović
M
M
Klinika za infektivne i dermatoveneroloske bolesti, Medicinski fakultet, Novi Sad.
Poljacki
M
M
Milakov
J
J
Duran
V
V
Stojanović
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017449:Dermatitis, Allergic Contact / Q000276:immunology*; D004198:Disease Susceptibility; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D010641:Phenotype
D006680:HLA Antigens
Fenotipizacija: nas doprinos ispitivanju veće prijemcivosti pojedinih kombinacija HLA-fenotipova u okviru individualne predispozicije za kontaktnu alergiju.