Effects of marijuana history on the subjective, psychomotor, and reinforcing effects of nitrous oxide in humans.
An experiment using marijuana users and non-users was conducted to assess whether the reinforcing, subjective, or psychomotor effects of nitrous oxide were influenced by a subject's drug history. Subjects in the first four sessions sampled 40% nitrous oxide in oxygen and 100% oxygen (placebo), and then over the next three sessions, chose which agent they wished to inhale. Choice distributions between the two groups did not differ significantly, and nitrous oxide choice rates were less than 50% in both groups. However, a history of marijuana use appeared to intensify some of the subjective effects induced by nitrous oxide inhalation.
Yajnik
S
S
Department of Anesthesia and Critical Care, University of Chicago, IL 60637.
Thapar
P
P
Lichtor
J L
JL
Patterson
T
T
Zacny
J P
JP
D000280:Administration, Inhalation; D000328:Adult; D000339:Affect / Q000187:drug effects*; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000523:psychology*; D009042:Motivation; D009483:Neuropsychological Tests; D009609:Nitrous Oxide / Q000494:pharmacology*; D010555:Personality Inventory; D011597:Psychomotor Performance / Q000187:drug effects*
D009609:Nitrous Oxide