q-Space imaging of the brain.
q-Space imaging (Callaghan, J. Magn. Reson. 88, 493 (1990)) has been used to obtain mouse brain water displacement profiles. These profiles take the form of a unidirectional incoherent-displacement probability density distribution. Two groups of mice were studied, a normal group and one in which surgery had been performed to reduce the supply of blood to the forebrain. In the normal group the incoherent displacement of water was reduced postmortem. Four of the surgically treated mice yielded displacement profiles that resembled those obtained postmortem; the remaining two were near normal. This study demonstrates the feasibility of in vivo q-space imaging. The displacement profile changes that occur subsequent to an interruption of the forebrain blood supply are consistent with the hyperintensity changes seen in diffusion-weighted imaging.
King
M D
MD
Royal College of Surgeons Unit Biophysics, Institute of Child Health, London, United Kingdom.
Houseman
J
J
Roussel
S A
SA
van Bruggen
N
N
Williams
S R
SR
Gadian
D G
DG
D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology; D001923:Brain Chemistry; D002545:Brain Ischemia / Q000175:diagnosis* / Q000378:metabolism; D004058:Diffusion; D005240:Feasibility Studies; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D008961:Models, Structural