Idiopathic infantile hypercalcemia discovered in the newborn period.
We report a male newborn with typical clinical signs of idiopathic infantile hypercalcemia (IIH); that is, hypercalcemia, hypercalciuria, an elfin face and nephrocalcinosis without giving Vitamin D3 supplementation to the patient. He had been treated with a vitamin D-free, low calcium milk and rectal administration of exogenous calcitonin (elcatonin). The latter seemed to be more effective as a treatment for IIH. The serum calcium level came within the normal range and the serum 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) level decreased from 101.5 to 75.6 pg/mL with the treatments mentioned above. These results suggest that a high serum concentration of 1,25(OH)2D3 is part of the pathogenesis of IIH. However, we were not able to clarify the pathogenesis of the high serum concentration of 1,25(OH)2D3.
Shimizu
H
H
Department of Pediatrics, Himeji Red Cross Hospital, Japan.
Kodama
S
S
Takeuchi
A
A
Matui
T
T
Nakao
H
H
Sakurai
T
T
Kobayashi
T
T
D000285:Administration, Rectal; D002114:Calcinosis / Q000473:pathology; D002116:Calcitonin / Q000008:administration & dosage / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood / Q000652:urine; D004035:Diet Therapy; D005149:Facial Expression; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology; D008297:Male
D002116:Calcitonin; D002118:Calcium