Biomaterial-host interactions: consequences, determined by implant retrieval analysis.
Prosthetic biomaterials have had a profound impact on reconstructive surgery but complete biocompatability remains illusive. This review considers the retrieval analysis of four common prosthetic structures: the hip, the knee, heart valves, and blood vessels. We show that despite a fine record of early success, deterioration due to mechanical failure or deleterious host responses to the implant may compromise long term function. The eventual retrieval and detailed analysis of implanted structures provides an invaluable opportunity to determine the characteristics of implant success or failure and to provoke the development of still better materials.
Kaplan
S S
SS
Department of Pathology, University of Pittsburgh, School of Medicine, PA 15213.
D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001807:Blood Vessel Prosthesis; D006350:Heart Valve Prosthesis; D006622:Hip Prosthesis; D006801:Humans; D007249:Inflammation; D007720:Knee Prosthesis; D008422:Materials Testing / Q000379:methods; D016348:Osseointegration; D011358:Product Surveillance, Postmarketing
D001672:Biocompatible Materials