A developmental-genetic model of alcoholism: implications for genetic research.
The research for biological-genetic markers of alcoholism is discussed in the context of a multifactorial, heterogeneous, developmental model of the disease. It is suggested that the strategies used in both linkage and association studies require modification to accommodate this more complex model. It is also suggested that several extant associations of genetic markers with alcoholism represent true secondary interactive phenomena that alter the outcome of primary alcoholism genotypes at the phenotype level.
Devor
E J
EJ
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City 52242-1057.
D000437:Alcoholism / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D002880:Chromosomes, Human, Pair 11; D005819:Genetic Markers / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008957:Models, Genetic; D008995:Monoamine Oxidase / Q000235:genetics; D010641:Phenotype; D017448:Receptors, Dopamine D2 / Q000235:genetics; D012307:Risk Factors
D005819:Genetic Markers; D007527:Isoenzymes; D017448:Receptors, Dopamine D2; D000444:Aldehyde Dehydrogenase; D008995:Monoamine Oxidase