title: Decrease in cerebellar blood flow in patients with Friedreich's ataxia: A TC-HMPAO SPECT study of three cases.
abstract: Three cases of Friedreich's ataxia were submitted to diverse neuroradiological procedures in order to determine the extent of atrophic processes in the central nervous system. All patients underwent computerized-tomography scan, Magnetic Resonance Imaging, and HMPA-single Photon emission computerized tomography studies, focusing in cerebellar lobes. A slight atrophy was observed in the vermis and the cerebellar lobes with CT scan and MRI. In contrast a significant decrease in cerebellar blood flow was shown by TC-HMPAE SPECT study. The significance of these findings in understanding physiopathological mechanisms in Friedreich's ataxia is discussed.
authors.affiliation: Service de Neurologie, CHU, Dijon, France.
authors.forename: M
authors.initials: M
authors.lastname: Giroud
authors.forename: L
authors.initials: L
authors.lastname: Septien
authors.forename: J L
authors.initials: JL
authors.lastname: Pelletier
authors.forename: N
authors.initials: N
authors.lastname: Dueret
authors.forename: R
authors.initials: R
authors.lastname: Dumas
mesh_terms: D000328:Adult; D001284:Atrophy; D002531:Cerebellum / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005621:Friedreich Ataxia / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime