title: Deletion 6q in three cases of mixed-type liposarcoma in addition to t(12;16)(q13;p11)
abstract: We report the cytogenetic findings in three mixed liposarcoma following short-term cultures. During the course of cytogenetic investigation of various types of liposarcomas, we observed an interstitial deletion of the long arm of chromosome 6 together with the translocation (12;16)(q13;p11) in three tumors. Translocation (12;16) is associated with myxoid and mixed (myxoid/round cell) liposarcomas, although deletion of chromosome 6 has been observed in only a few of these tumors. Our findings suggest that del(6), as an additional change in myxoid liposarcoma, is probably related to tumor progression.
authors.affiliation: Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
authors.forename: O
authors.initials: O
authors.lastname: Altungoz
authors.forename: A M
authors.initials: AM
authors.lastname: Meloni
authors.forename: A
authors.initials: A
authors.lastname: Peier
authors.forename: M
authors.initials: M
authors.lastname: Zalupski
authors.forename: S
authors.initials: S
authors.lastname: Spanier
authors.forename: J S
authors.initials: JS
authors.lastname: Brooks
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000328:Adult; D000368:Aged; D002881:Chromosomes, Human, Pair 12; D002885:Chromosomes, Human, Pair 16; D002896:Chromosomes, Human, Pair 6; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D008080:Liposarcoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic