title: The protective effects of high-dose ascorbic acid on myocardium against reperfusion injury during and after cardiopulmonary bypass.
abstract: The protective effects of high-dose ascorbic acid (250 mg/kg) on the myocardium were observed in 85 patients undergoing Cardiopulmonary Bypass (CPB). The changes in serum Malonyldialdehyde (MDA). Creatine Phosphokinase (CPK), Creatine Phosphokinase isozyme (CPK-MB) and Lactic Dehydrogenase (LDH) in group B (n = 45, receiving ascorbic acid) were lower (p < 0.05) than in group A (n = 40, no ascorbic acid) during and after CPB. The MDA remained at a higher level two days postoperatively; CPK and CPK-MB, the sensitive and specific reflectors of myocardial injury, recovered very slowly in the control group (A) after the operation. The hearts in all the patients of group B resuscitated automatically intraoperatively while five cases (12.5%) needed defibrillation in group A. The cardiac index (CI) measured in ICU in group B was higher than in group A (p < 0.05). The patients needed shorter ICU and hospital stays in group B than in group A. The results indicate that ascorbic acid can act as a scavenger of free radicals to decrease the peroxidation of the lipids present in the cell membrane and remove the radicals to protect the myocardium from ischemia-reperfusion injury effectively during and after open-heart operation.
authors.affiliation: Department of Cardiovascular Surgery, First Medical College of Xian Medical University, Peoples Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Dingchao
authors.forename: Q
authors.initials: Q
authors.lastname: Zhiduan
authors.forename: H
authors.initials: H
authors.lastname: Liye
authors.forename: F
authors.initials: F
authors.lastname: Xiaodong
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D003402:Creatine Kinase / Q000097:blood; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*
chemical_list: D007527:Isoenzymes; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D001205:Ascorbic Acid