[The effects of Panax quinquefolium saponin (PQS) and its monomer ginsenoside on heart].
Experiments have shown that PQS (0.03-3 mg/ml) can inhibit the contractility of papillary muscle of guinea pigs, and on depolarized sample of papillary muscle with high potassium, PQS (0.03-0.3 mg/ml) can increase this contractility. Monomer saponin-Re (10 mg/kg),-Rb3 (30 mg/kg) can inhibit the hemodynamic indication of rats, but pseudogisenoside-F11 (10 mg/kg) acts the other way round. These results prove that PQS contains two components of opposite actions.
Chen
X
X
Norman Bethune University of Medical Sciences, Changchun.
Yang
S J
SJ
Chen
L
L
Ma
X L
XL
Chen
Y P
YP
Wang
L L
LL
Sun
C W
CW
D000818:Animals; D003864:Depression, Chemical; D036145:Ginsenosides; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D005894:Panax / Q000737:chemistry*; D010210:Papillary Muscles / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D013268:Stimulation, Chemical
D036145:Ginsenosides; D012503:Saponins