The immediate 5'-flanking region of the rat phenylalanine hydroxylase-encoding gene.
We have characterized the immediate (465 bp) 5'-flanking region of the rat phenylalanine hydroxylase (PAH)-encoding gene. This sequence shows considerable similarity to the 5'-flanking region of the human PAH gene [Konecki et al., Biochemistry 31 (1992) 8363-8368]. Both sequences lack obvious TATA elements; however, putative regulatory sites, including a potential cyclic AMP-response element and glucocorticoid response elements, are present.
McDowall
I L
IL
Department of Biochemistry, University of Liverpool, UK.
Fisher
M J
MJ
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D000242:Cyclic AMP / Q000502:physiology; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D010651:Phenylalanine Hydroxylase / Q000235:genetics*; D051381:Rats; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D005938:Glucocorticoids; D000242:Cyclic AMP; D010651:Phenylalanine Hydroxylase