title: [Percutaneous alcohol injection in hyperparathyroidism. Experience in 11 cases with an 18-month follow-up].
abstract: The authors report the results of US-guided percutaneous ethanol injection into parathyroid glands of 11 patients with primary (2) and secondary (9) hyperparathyroidism. Selection criteria for choosing ethanol treatment were the patient's refuse of surgery and high surgical risks for age or severe chronic intercurrent conditions. At 18 months' follow-up, PTH serum levels had normalized in 2 primary and 2 secondary hyperparathyroidism patients; in all the others but one, PTH levels markedly decreased--always > 50% relative to pretreatment values. Serum calcium and phosphorus levels also decreased, which was not always the case with alkaline phosphatase. After injection, the glands became progressively hyperechoic, gland volume decreased and calcifications appeared. Parenchymal flow disappeared on color-Doppler US images. This study confirms the capabilities of US-guided ethanol injection in hyperfunctioning parathyroids, even though complications may occur and the condition recur. This method is thus suggested as an effective alternative to surgery.
authors.affiliation: Istituto di Radiologia, Università di Perugia.
authors.forename: A
authors.initials: A
authors.lastname: Lemmi
authors.forename: M
authors.initials: M
authors.lastname: Baroni
authors.forename: C
authors.initials: C
authors.lastname: Malaspina
authors.forename: F
authors.initials: F
authors.lastname: Rizzo
authors.forename: G
authors.initials: G
authors.lastname: Biscarini
authors.forename: P
authors.initials: P
authors.lastname: Filipponi
authors.forename: G
authors.initials: G
authors.lastname: Gubbiotti
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000188:drug therapy; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D000431:Ethanol / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy; D010280:Parathyroid Glands / Q000000981:diagnostic imaging; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D010758:Phosphorus / Q000097:blood; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D000431:Ethanol; D000469:Alkaline Phosphatase; D002118:Calcium
vernacular_title: Alcolizzazione percutanea nell'iperparatiroidismo. Esperienza in 11 casi con follow-up a 18 mesi.