Tobacco smoking impairs the local immunosurveillance in the uterine cervix. An immunohistochemical study.
Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cervix. This suggests a local impairment of cell-mediated immunity by smoking. This immunosuppressive effect could support the concept that smoking is an independent risk factor for cervical neoplasia.
Poppe
W A
WA
Department of Obstetrics and Gynecology, KU Leuven, Belgium.
Ide
P S
PS
Drijkoningen
M P
MP
Lauweryns
J M
JM
Van Assche
F A
FA
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D002452:Cell Count; D002584:Cervix Uteri / Q000276:immunology* / Q000473:pathology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007157:Immunologic Surveillance; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects*; D016176:T-Lymphocyte Subsets / Q000276:immunology
D006684:HLA-DR Antigens