title: The phototumorigenic potential of broad-band (270-350 nm) and narrow-band (311-313 nm) phototherapy sources cannot be predicted by their edematogenic potential in hairless mouse skin.
abstract: The new Philips TL01 narrow-band (311-313 nm) and conventional broad-band (e.g., Philips TL12; 270-350 nm) sources are effective for psoriasis phototherapy, for which treatment regimens are based on a predetermined minimal erythema dose. TL01 phototherapy treatment times are approximately half those with TL12 for psoriasis, whereas the cumulative exposure doses at clearing are similar. We compared the phototumorigenic potential of TL01 and TL12 radiation in mouse skin. Groups of albino Skh-1 hairless mice were exposed for 5 d/week at three dose levels. At each dose level, TL12 and TL01 doses were equally edematogenic. At each dose level, TL01 radiation was significantly more effective at producing first tumors of 1 mm in diameter and multiple tumors. At the lower two dose levels, TL01 radiation produced a significantly greater proportion of squamous cell carcinomas. This study demonstrates that TL01 radiation is more phototumorigenic than TL12 radiation at equally edematogenically weighted doses. This is in contrast with previous reports that edema production by polychromatic sources is predictive of their phototumorigenic effect in Skh-1 mice. The absolute cumulative TL12 dose needed to induce tumors was much less than that for TL01 radiation. The possibility of increased tumor risk with TL01 phototherapy should be considered but must be balanced against the high phototherapeutic efficacy of this source, short treatment times, and the low cumulative doses necessary for clearing of psoriasis.
authors.affiliation: Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom.
authors.forename: N K
authors.initials: NK
authors.lastname: Gibbs
authors.forename: N J
authors.initials: NJ
authors.lastname: Traynor
authors.forename: R M
authors.initials: RM
authors.lastname: MacKie
authors.forename: I
authors.initials: I
authors.lastname: Campbell
authors.forename: B E
authors.initials: BE
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004487:Edema / Q000209:etiology; D005260:Female; D015994:Incidence; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000528:radiation effects; D013471:Sunburn / Q000209:etiology; D014466:Ultraviolet Rays / Q000009:adverse effects