[The expression of PCNA and EGF gamma in tumor cells of experimental hepatocellular carcinoma of liver and squamous cell carcinoma of stomach in rats].
The expression of PCNA and EGF gamma in chemically induced hepatocellular carcinoma and squamous cell carcinoma cells from rats were observed with immunohistochemical techniques. The results showed that the carcinoma cells of both tumors revealed a positive immunoreaction to both factors. According to the amount of MC surrounding the tumor cell nests, the specimens could be divided into two groups: the group with abundant MC infiltration and the group with little or no MC infiltration. The PCNA positive cells in carcinoma cell nests of both groups were calculated respectively. It revealed that the amount of PCNA positive cells in the group with little or no MC was significantly more than that in the other group. The ratio between the 2 groups in liver carcinoma was approximately 3:1 and in stomach cancer it was 2:1. An overexpression of EGF gamma was observed in tumor tissues of both groups, but the amount of EGF gamma positive cells in the group with little or no MC was much higher than that of the group with abundant MC.
Ruan
Y B
YB
Department of Ultrastructural Pathology, Tongji Medical University, Wuhan.
Wu
Z B
ZB
D000818:Animals; D002110:Caffeine / Q000031:analogs & derivatives; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000737:chemistry*; D004052:Diethylnitrosamine; D066246:ErbB Receptors / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000737:chemistry*; D008297:Male; D008407:Mast Cells / Q000276:immunology; D009602:Nitrosamines; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000737:chemistry*
D009602:Nitrosamines; D018809:Proliferating Cell Nuclear Antigen; C082388:dinitrosocaffeidine; D002110:Caffeine; D004052:Diethylnitrosamine; D066246:ErbB Receptors