title: Synthesis and pharmacology of two new histamine receptor antagonists related to ranitidine.
abstract: Pyridyl and 1,6-dihydropyridyl ranitidine analogues 1 and 2 were obtained by applying an improved modification of ranitidine synthesis. Compound 1 shows a selective H2 antagonistic activity while compound 2 is a non-selective histamine antagonist.
authors.affiliation: Departamento de Química Orgánica, Facultad de Quimicas, Salamanca, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Navarro
authors.forename: J F
authors.initials: JF
authors.lastname: Almeida
authors.forename: J
authors.initials: J
authors.lastname: Anaya
authors.forename: J R
authors.initials: JR
authors.lastname: Moran
authors.forename: M
authors.initials: M
authors.lastname: Grande
authors.forename: M C
authors.initials: MC
authors.lastname: Caballero
authors.forename: B
authors.initials: B
authors.lastname: Palacios
authors.forename: M J
authors.initials: MJ
authors.lastname: Montero
authors.forename: L
authors.initials: L
authors.lastname: San Roman
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011899:Ranitidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; C092458:N-(2-(((5-(dimethylaminomethyl)-2-furanyl)methyl)thio)ethyl)-(3-nitro-1,6-dihydropyridin-2-yl)amine; C092459:N-(2-((5-((dimethylamino)methyl)-2-furanyl)methylthio)ethyl)-(3-nitropyridin-2-yl)amine; D011899:Ranitidine