title: Fine-needle aspiration biopsy diagnosis of extrarenal malignant rhabdoid tumor.
abstract: Two cases of extrarenal malignant rhabdoid tumors are presented in which diagnosis was suggested by fine-needle aspiration biopsy and confirmed by histologic and electron microscopic examination. Fine-needle aspiration smears in both cases revealed round to polygonal cells with vesicular nuclei and prominent nucleoli. Several tumor cells contained cytoplasmic inclusions composed of intermediate filaments. A majority of the tumor cells stained strongly for vimentin and cytokeratin. Electron microscopic examination revealed many cells with large aggregates of intermediate filaments corresponding to the cytoplasmic inclusions. Fine-needle aspiration biopsy may be used for diagnosing malignant rhabdoid tumor. The diagnosis may be further confirmed by immunohistochemistry and electron microscopy.
authors.affiliation: Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: Akhtar
authors.forename: H
authors.initials: H
authors.lastname: Kfoury
authors.forename: A
authors.initials: A
authors.lastname: Haider
authors.forename: K
authors.initials: K
authors.lastname: Sackey
authors.forename: M A
authors.initials: MA
authors.lastname: Ali
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology*; D001707:Biopsy, Needle; D002648:Child; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D018335:Rhabdoid Tumor / Q000473:pathology*