title: Preliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology.
abstract: It has been suggested that childhood leukaemia may be the abnormal outcome of a common infection. Rare events caused by common environmental events such as infections are likely to be influenced by host genetic susceptibility. We have therefore investigated whether immunogenetic susceptibility contributes to the risk of childhood common ALL (c-ALL). In this preliminary study, we report that children with c-ALL (n = 63) carry the HLA-DPB1 locus allele *0201 twice and nearly three times more frequently than adult (n = 92; relative risk (RR) = 2.9, P < 0.05) or infant controls (n = 82; RR = 2.1). Moreover, children with c-ALL are 3-4 times more likely than controls to be heterozygous for DPB1*0201/*0301, /*0401 and /*0402 (RRadult controls = 3.9; RRinfant controls = 2.8). These results suggest that HLA-DPB1*0201 either alone or with other DPB1 alleles contributes to the risk of childhood c-ALL, possibly by increasing susceptibility to an infectious agent.
authors.affiliation: Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
authors.forename: G M
authors.initials: GM
authors.lastname: Taylor
authors.forename: M D
authors.initials: MD
authors.lastname: Robinson
authors.forename: A
authors.initials: A
authors.lastname: Binchy
authors.forename: J M
authors.initials: JM
authors.lastname: Birch
authors.forename: R F
authors.initials: RF
authors.lastname: Stevens
authors.forename: P M
authors.initials: PM
authors.lastname: Jones
authors.forename: T
authors.initials: T
authors.lastname: Carr
authors.forename: S
authors.initials: S
authors.lastname: Dearden
authors.forename: D A
authors.initials: DA
authors.lastname: Gokhale
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006682:HLA-DP Antigens / Q000032:analysis / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D007223:Infant; D007239:Infections / Q000150:complications* / Q000276:immunology; D008297:Male; D016133:Polymerase Chain Reaction; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology* / Q000235:genetics / Q000276:immunology
chemical_list: D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen