[Activation of endothelium-dependent hemostatic factors following bone marrow transplantation].
Changes in hemostatic factors after bone marrow transplantation (BMT), with or without thrombotic complications, have already been described. The endothelium seems to be actively involved in such processes. Over a period of 2 years we evaluated various hemostatic factors, associated or not with endothelial stimulation, in 44 patients with BMT (40 leukemias and 4 aplastic anemias). Factor VIII activity (VIII:C), von Willebrand factor antigen (vWF:Ag), tissue plasminogen activator antigen (tPA), plasminogen activator inhibitor activity (PAI-1), antithrombin III, protein C and protein S were assayed before and 1, 3, 6, 12, 18, and 24 months after BMT. Factor VIII:C, vWF and tPA were found to be significantly increased 1-6 months after BMT, returning to normal later. Patients with acute graft versus host disease, fever or cyclosporin treatment had significantly higher VIII:C, vWF and tPA. The increase in these factors implies lasting stimulation of their release and/or synthesis from endothelial cells that is enhanced by some complications of BMT. The degree and character of these changes could favor activation of thrombotic processes.
Tsakiris
D A
DA
Gerinnungslabor DZL, Kantonsspital Basel.
Marbet
G A
GA
Tichelli
A
A
Gratwohl
A
A
Speck
B
B
D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000096:biosynthesis*; D016026:Bone Marrow Transplantation / Q000502:physiology*; D016572:Cyclosporine / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000378:metabolism*; D005169:Factor VIII / Q000096:biosynthesis; D006086:Graft vs Host Disease / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010960:Plasminogen Activators / Q000096:biosynthesis; D013997:Time Factors; D014841:von Willebrand Factor / Q000096:biosynthesis
D001779:Blood Coagulation Factors; D014841:von Willebrand Factor; D016572:Cyclosporine; D005169:Factor VIII; D010960:Plasminogen Activators
Aktivierung Endothel-abhängiger hämostatischer Faktoren nach Knochenmarktransplantation.