Successful treatment of Kaposi's sarcoma with interferon-alpha in a patient with acquired immunodeficiency syndrome.
Although combined therapy with interferon-alpha and zidovudine may be safely administered to some patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi sarcoma, no ethnic Chinese patient has been successfully treated before in this area. This case report concerns a 47-year-old male with a history of bisexuality who had suffered from oral ulcers for half a year, Human immunodeficiency virus (HIV) serology was positive, and pathology of the oral ulcers disclosed Kaposi sarcoma. Combination therapy with zidovudine and interferon-alpha was initiated. The patient received a low-dose regimen of 5.0 million U interferon-alpha s.c. per day for 8 weeks and 5 million U twice a week for another 8 weeks. The oral ulcers faded away without recurrence. This report also reviews the literatures on treatment of AIDS-related Kaposi sarcoma with interferon.
Yeh
T S
TS
Department of Internal Medicine, National Taiwau University Hospital.
Wang
C R
CR
Wong
W W
WW
Jeng
G W
GW
Chen
M Y
MY
Liu
C Y
CY
Chuang
C Y
CY
Chen
W Y
WY
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000628:therapy*; D015215:Zidovudine / Q000627:therapeutic use
D016898:Interferon-alpha; D015215:Zidovudine