title: [The role of the maternal genotype in the realization of the embryotoxic activity of teratogens].
abstract: Against the background of the induced iron deficit ethanol (6.4 g/kg) causes aggravation of the embryolethal effect and anomalies in 15% of embryos in 14-day pregnant rats. Changes in the genome of rat males and females after the injection of the plasmid with a foreign gene at the stage of two pronuclei and the subsequent crossing with intact animals account for the increase in sensitivity of embryos to subteratogenic doses of sodium salicilate. The maternal organism disturbances have a more pronounced effect than the paternal ones.
authors.forename: N A
authors.initials: NA
authors.lastname: Chebotar'
authors.forename: L A
authors.initials: LA
authors.lastname: Konopistseva
authors.forename: T V
authors.initials: TV
authors.lastname: Ignat'eva
authors.forename: G F
authors.initials: GF
authors.lastname: Golinskiĭ
authors.forename: V F
authors.initials: VF
authors.lastname: Puchkov
authors.forename: A P
authors.initials: AP
authors.lastname: Dyban
mesh_terms: D015082:2,2'-Dipyridyl / Q000008:administration & dosage; D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000235:genetics*; D018798:Anemia, Iron-Deficiency / Q000139:chemically induced / Q000150:complications / Q000235:genetics; D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects*; D000431:Ethanol / Q000633:toxicity; D005260:Female; D016678:Genome; D005838:Genotype; D008297:Male; D010957:Plasmids / Q000008:administration & dosage; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D051381:Rats; D012980:Sodium Salicylate / Q000633:toxicity
chemical_list: D000431:Ethanol; D015082:2,2'-Dipyridyl; D012980:Sodium Salicylate
vernacular_title: Rol' genotipa materi v realizatsii émbriotoksicheskoĭ aktivnosti nekotorykh teratogenov.