title: Familial polyarteritis nodosa.
abstract: Familial polyarteritis nodosa (PAN) is rare. We describe here two siblings who developed PAN 8 years apart. HLA typing showed that the affected family members shared a common haplotype with their unaffected mothers. Further study of the family history suggested the possibility of an inherited disorder of connective tissue predisposing to autoimmunity and aneurysm formation.
authors.affiliation: Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Mason
authors.forename: M R
authors.initials: MR
authors.lastname: Cowie
authors.forename: K A
authors.initials: KA
authors.lastname: Davies
authors.forename: J B
authors.initials: JB
authors.lastname: Schofield
authors.forename: J
authors.initials: J
authors.lastname: Cambridge
authors.forename: J
authors.initials: J
authors.lastname: Jackson
authors.forename: A
authors.initials: A
authors.lastname: So
authors.forename: S A
authors.initials: SA
authors.lastname: Allard
authors.forename: M J
authors.initials: MJ
authors.lastname: Walport
mesh_terms: D000293:Adolescent; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D010488:Polyarteritis Nodosa / Q000235:genetics*