title: Clinical laboratory manifestations of exposure to background levels of dioxins in the perinatal period.
abstract: The effects of exposure to low levels of dioxins in infants (intrauterine and via breast milk) were studied. In a group of 35 babies, specially selected, laboratory tests were performed in cord blood and in blood sampled at 7 days and 11 weeks of age. The outcome of these laboratory tests was related to dioxin concentrations in milk fat and cumulative dioxin intake. At 11 weeks of age, alanine aminotransferase and aspartate aminotransferase activities in plasma were significantly related to cumulative dioxin intake. A significant negative relation was found between platelet count and cumulative dioxin intake. The results of this study suggest that exposure to background levels of dioxins, both intrauterine and via breast milk, may have effects in newborns.
authors.affiliation: Department of Neonatology, Medical Faculty of the University of Amsterdam, Graduate School for Neurosciences, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Pluim
authors.forename: J G
authors.initials: JG
authors.lastname: Koppe
authors.forename: K
authors.initials: K
authors.lastname: Olie
authors.forename: J W
authors.initials: JW
authors.lastname: van der Slikke
authors.forename: P C
authors.initials: PC
authors.lastname: Slot
authors.forename: C J
authors.initials: CJ
authors.lastname: van Boxtel
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004147:Dioxins / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D008431:Maternal-Fetal Exchange; D008895:Milk, Human / Q000737:chemistry; D011247:Pregnancy
chemical_list: D004147:Dioxins; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase