Disseminated active HHV-6 infections in patients with AIDS.
Human herpesvirus 6 (HHV-6) infected cells were detected in all lung, lymph-node, spleen, liver, and kidney tissues obtained at necropsy from an unselected series of nine patients with AIDS. This infection rate was significantly higher than that for cytomegalovirus. Lung infection with HHV-6 was extensive enough in one patient to account for fatal pneumonitis. In other tissues increased numbers of HHV-6 infected cells were related to the presence of lymphocytes infiltrates or residual lymphoid tissue, with lymphocytes being predominantly infected. Thus HHV-6 is an important pathogen in patients with AIDS.
Knox
K K
KK
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226.
Carrigan
D R
DR
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D001344:Autopsy; D016022:Case-Control Studies; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000382:microbiology; D006566:Herpesviridae Infections / Q000382:microbiology*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000382:microbiology; D011024:Pneumonia, Viral / Q000382:microbiology