2-Methyl-1,2,3,4-tetrahydroisoquinoline does dependently reduce the number of tyrosine hydroxylase-immunoreactive cells in the substantia nigra and locus ceruleus of C57BL/6J mice.
2-Methyl-1,2,3,4-tetrahydroisoquinoline (2-MTIQ) was administered chronically to C57BL/6J mice. Light and electron microscopic examinations revealed atrophic neurons restricted to the central portion of the substantia nigra pars compacta (SNc) and pars lateralis as well as a reduction in tyrosine hydroxylase immunoreactivity, which showed a significant inverse correlation with the dose administered in the SNc. 2-MTIQ may be a candidate endogenous or environmental factor that induces parkinsonism.
Fukuda
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Division of Neuropathology, Jikei University School of Medicine, Tokyo, Japan.
D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D007546:Isoquinolines / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D013378:Substantia Nigra / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology; D044005:Tetrahydroisoquinolines; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism
D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C050386:1-methyl-1,2,3,4-tetrahydroisoquinoline; D014446:Tyrosine 3-Monooxygenase