title: The autologous mixed lymphocyte response: delayed T cell tolerance to B cells in XID mice.
abstract: The autologous mixed lymphocyte response (AMLR) is characterized by the proliferation of neonatal, but not adult, thymic T cells when cocultured with adult syngeneic B cells. Studies of the AMLR have revealed a temporal correlation between loss of T cell self-reactivity and development of stimulatory B cells. Such observations impart a role for B cells in the development of T cell tolerance. To test this hypothesis, we studied the AMLR in X-chromosome-linked immune-defective (XID) mice. As B cell maturation is delayed in this strain, we postulated that the AMLR-stimulatory capacity of B cells from XID mice might be impaired and lead to delayed acquisition of T cell tolerance. This report provides evidence that T cell tolerance to self-B cells is delayed in XID mice. Normal mice possess tolerant thymic T cells by 1 week of age, whereas thymic T cells in the XID mouse remain self-reactive through 4 weeks of age. These results reinforce a role for B cells in the development of T cell tolerance to self.
authors.affiliation: Department of Biology, Rider College, Lawrenceville, New Jersey 08648-3099.
authors.forename: J E
authors.initials: JE
authors.lastname: Riggs
authors.forename: F P
authors.initials: FP
authors.lastname: Maurio
authors.forename: L G
authors.initials: LG
authors.lastname: Prior
authors.forename: G R
authors.initials: GR
authors.lastname: Sirken
authors.forename: M V
authors.initials: MV
authors.lastname: Hobbs
mesh_terms: D000367:Age Factors; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D016747:Minor Lymphocyte Stimulatory Antigens; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D016747:Minor Lymphocyte Stimulatory Antigens