title: Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate.
abstract: Interferon-gamma is a T cell secreted cytokine. It has a great number of biological activities, among which is the down regulation of collagen molecules. IFN-gamma acts through cell surface receptors, but also binds to heparan sulfate proteoglycans. In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine.
authors.affiliation: Unité de Physiopathologie Cellulaire et Moléculaire des Fibroses Tissulaires-CNRS URA 1459, Institut Pasteur de Lyon, France.
authors.forename: H
authors.initials: H
authors.lastname: Lortat-Jacob
authors.forename: P
authors.initials: P
authors.lastname: Esterre
authors.forename: J A
authors.initials: JA
authors.lastname: Grimaud
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D005355:Fibrosis / Q000378:metabolism; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D006497:Heparan Sulfate; D007371:Interferon-gamma