title: Effect of the sulfonylurea glyburide on glycogen synthesis in alloxan-induced diabetic rat hepatocytes.
abstract: 1. The effect of glyburide (glibenclamide) treatment on the liver glycogen levels of diabetic rats have been studied. 2. 3 weeks treatment with glyburide (5 mg/kg, orally) increased liver glycogen and decreased blood glucose levels. 3. The results of this study demonstrated that the sulfonylurea, glyburide is capable of exerting direct insulin-like effects on liver glycogen values in vivo.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Gazi, Besevler, Ankara, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Atalay
authors.forename: N
authors.initials: N
authors.lastname: Altan
authors.forename: C O
authors.initials: CO
authors.lastname: Ongun
authors.forename: H
authors.initials: H
authors.lastname: Alagöl
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008112:Liver Glycogen / Q000096:biosynthesis*; D051381:Rats
chemical_list: D008112:Liver Glycogen; D005905:Glyburide