Soleus muscle alterations in spontaneously hypertensive rats are not dependent on activation of beta 2-adrenergic receptors.
The effects of selective beta 2-adrenergic blockade with ICI 118,551 on the histochemical, biochemical, and contractile properties of slow-twitch soleus muscle from spontaneously hypertensive (SHR) and normotensive (WKY) rats were examined from birth to 8-10 weeks of age. Chronic treatment of normotensive rats with ICI 118,551 caused an impairment in the differentiation of slow type fibers during development but failed to alter the fiber type distribution of hypertensive rats. beta 2-Adrenoreceptor blockade was ineffective in reducing the enhanced glycolytic and oxidative capacities of soleus in hypertensive rats. The suggestion can be made that beta 2-adrenoreceptor activation is not responsible, at least directly, for the histochemical and biochemical alterations of slow muscle from hypertensive rats.
Benbachir-Lamrini
L
L
Unité de Recherches Associée 1341 Centre National de la Recherche Scientifique, Université Claude Bernard, Lyon, France.
Koubi
H
H
Sempore
B
B
Mayet
M H
MH
Frutoso
J
J
Cottet-Emard
J M
JM
Favier
R J
RJ
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002395:Catecholamines / Q000097:blood; D005260:Female; D006614:Hindlimb / Q000098:blood supply; D006651:Histocytochemistry; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology*; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects*; D012039:Regional Blood Flow / Q000502:physiology; D013963:Thyroid Hormones / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D011412:Propanolamines; D018343:Receptors, Adrenergic, beta-2; D013963:Thyroid Hormones; C026777:ICI 118551