Two-sample hemodialysis urea kinetic modeling: validation of the method.
Urea kinetic modeling (UKM) by a two-sample method (UKM2) was compared with the classical three-sample method (UKM3) and direct quantification. Assuming the patient to be in a weekly steady state and using an approximate treatment schedule, UKM2 can compute urea generation rate (G), distribution volume (V), Kt/V, and normalized protein catabolic rate (NPCR). Twenty-three stable patients were examined. The results obtained by UKM2 and UKM3 differed little (G -4.2%, V -1.0%, Kt/V 0.9%, NPCR -2.7%), and the correlations between them were high (r > or = 0.96). The differences between UKM2 and direct quantification were greater, but also highly correlated. G determined midweekly by UKM2 was highly correlated with G found directly from 1-week collection of dialysate and urine (r = 0.96). Repeating analysis over a 5-week period, the results obtained by UKM2 varied no more than those obtained by UKM3 (around 8% for all four kinetic variables). In conclusion, UKM2 produces reliable results requiring less data to be entered than using UKM3.
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Department of Renal Medicine, St. James's University Hospital, Leeds, UK.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003956:Dialysis / Q000379:methods; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D008954:Models, Biological; D006435:Renal Dialysis; D015203:Reproducibility of Results; D014508:Urea / Q000032:analysis* / Q000097:blood / Q000378:metabolism
D014508:Urea