title: Neuroleptics differentially induce jun family genes in the rat striatum.
abstract: The effect of neuroleptics in single administration on the expression of genes of the jun family was studied in the rat striatum. jun B, but not jun D was dose-dependently and transiently induced. This effect was blocked by pretreatment with a specific dopamine D2 agonist. The expression of c-jun was also stimulated, although this did not reach statistical significance. Thus dopamine D2 receptors differentially regulate the expression of jun family members in the striatum.
authors.affiliation: Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires UPR 416 du CNRS, Centre de Neurochimie, Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Rogue
authors.forename: A N
authors.initials: AN
authors.lastname: Malviya
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D016758:Genes, jun; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2