Reduced locomotor activity of rats mediated by peripheral beta adrenergic receptors.
The nonselective beta adrenergic agonist isoproterenol, the beta-2 selective agonist clenbuterol and, to a lesser extent, the beta-1 selective agonists dobutamine and prenalterol reduced locomotor activity of rats in a dose-dependent manner. These effects were antagonized by the beta adrenergic antagonist propranolol, suggesting mediation by beta adrenergic receptors. The hydrophilic beta adrenergic antagonist CGP-12177, which crosses the blood-brain barrier poorly, also blocked the effect of clenbuterol on locomotor activity with a potency similar to propranolol, suggesting that stimulation of peripheral beta adrenergic receptors is sufficient for reducing locomotor activity.
O'Donnell
J M
JM
Department of Pharmacology and Therapeutics, Louisiana State University School of Medicine, Shreveport, 71130.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta