Regulation of immunological memory.
Immunological memory can be regulated during either its development or its maintenance phases. Controversy and confusion surround both methods of regulation, especially in the field of T-cell memory. Recent work has helped in improving our definition of 'a memory cell', but this has been complicated by another major point of contention: whether memory cells are maintained by antigens or other stimuli. Unequivocal advances have recently been made concerning the molecular events involved in memory B cell generation in germinal centers.
Gray
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Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*