title: Inhibition by lead of the calcium plateau current at mouse motor nerve endings.
abstract: The inhibition by lead of motor terminal calcium plateau signals has been studied using extracellular, perineuronal electrodes applied to the M. triangularis sterni preparation of the mouse. The long-lasting calcium pateau signal induced by 3,4-DAP (250 mumol) and TEA (10 mmol) blockade of presynaptic potassium channels was irreversibly blocked by micromolar lead concentrations in a concentration-dependent manner. These results suggest that lead antagonizes neuronal calcium channels involved in transmitter release from motor nerve terminals.
authors.affiliation: Medical Institute of Environmental Hygiene, Heinrich-Heine-University Düsseldorf, Department of Neurotoxicology, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Wiegand
authors.forename: M
authors.initials: M
authors.lastname: Heck
authors.forename: U
authors.initials: U
authors.lastname: Gotzsch
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D044182:Benzylisoquinolines; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000633:toxicity; D003035:Cobalt / Q000494:pharmacology; D007854:Lead / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D009046:Motor Neurons / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000470:Alkaloids; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; C009438:tetrandrine; D007854:Lead; D003035:Cobalt; D002118:Calcium