title: Randomised trial of oral aspirin for chronic venous leg ulcers.
abstract: The effect of oral aspirin on the healing rate of chronic venous leg ulcers was compared with that of placebo in a double-blind randomised trial. 20 subjects with chronic venous leg ulcers were randomised to daily enteric-coated aspirin 300 mg or placebo, and standardised compression bandaging. 4 months of treatment achieved ulcer healing in 38% of the patients receiving aspirin compared with 0% of those receiving placebo (p < 0.007). 52% of the aspirin-treated group showed significant reduction in ulcer size compared with 26% of placebo recipients (p < 0.007). Reduction in ulcer surface area was significantly better in the aspirin-treated group at 2 (p < 0.01) and 4 months (p < 0.002) compared with that in the placebo group.
authors.affiliation: Academic Unit of Dermatology, General Infirmary at Leeds, West Yorkshire, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Layton
authors.forename: S H
authors.initials: SH
authors.lastname: Ibbotson
authors.forename: J A
authors.initials: JA
authors.lastname: Davies
authors.forename: M J
authors.initials: MJ
authors.lastname: Goodfield
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000627:therapeutic use*; D001458:Bandages; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014647:Varicose Ulcer / Q000188:drug therapy* / Q000628:therapy
chemical_list: D001241:Aspirin