Mammary excretion of cannabidiol in rabbits after intravenous administration.
The present study examined the distribution of cannabidiol into milk after an intravenous bolus injection (3 mg kg-1) to lactating rabbits. Drug concentrations in milk and serum were measured by HPLC. Cannabidiol was excreted into milk rapidly and the drug levels in milk increased over a 4-24-h period following the maternal injection. The mean milk to serum concentration ratio was 25.9, indicating a significant accumulation of the drug in milk.
Yoo
S D
SD
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia 29208.
Fincher
T K
TK
Holladay
J W
JW
D000818:Animals; D002185:Cannabidiol / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007275:Injections, Intravenous; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008892:Milk / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits
D002185:Cannabidiol