The PGPA gene of Leishmania major mediates antimony (SbIII) resistance by decreasing influx and not by increasing efflux.
Callahan
H L
HL
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Roberts
W L
WL
Rainey
P M
PM
Beverley
S M
SM
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000965:Antimony / Q000493:pharmacokinetics / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics; D017125:Genes, Protozoan; D017136:Ion Transport / Q000235:genetics; D018320:Leishmania major / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D013696:Temperature; D014162:Transfection
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000965:Antimony