Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics.
Since gamma-hydroxybutyrate receptor agonists exhibit dopaminergic regulatory properties and neuroleptic-like effects in neuropharmacological tests, the common neuroleptics were tested for [3H] gamma-hydroxybutyrate binding activity on rat brain membranes. (-)-Sulpiride, sultopride, amisulpride and prochlorperazine possess affinity for the gamma-hydroxybutyrate site(s), consistent with their therapeutic dosage. This study has revealed that gamma-hydroxybutyrate receptors represent an additional target for antipsychotics.
Maitre
M
M
Centre de Neurochimie, UPR 416 du CNRS, Strasbourg, France.
Ratomponirina
C
C
Gobaille
S
S
Hodé
Y
Y
Hechler
V
V
D000818:Animals; D014150:Antipsychotic Agents / Q000493:pharmacokinetics*; D001549:Benzamides / Q000493:pharmacokinetics*; D001667:Binding, Competitive; D066298:In Vitro Techniques; D008297:Male; D011346:Prochlorperazine / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012978:Sodium Oxybate / Q000493:pharmacokinetics*
C039403:4-hydroxybutyric acid receptor; D014150:Antipsychotic Agents; D001549:Benzamides; D011956:Receptors, Cell Surface; D012978:Sodium Oxybate; D011346:Prochlorperazine