[The dynamic reactivity of cortical neurons to the repeated isolated action of L-glutamate and acetylcholine].
Comparative analysis of the probability, direction and magnitude of changes of the mean firing rates for the background and L-glutamate--(Glu) and acetylcholine--(ACh) induced activity of single sensorimotor cortical neurons of unanesthetized rats showed that more significant changes occurred in reaction to the applications of Glu. Increases of Glu-induced activity were more frequent than increases of ACh-induced activity in the course of 20 microiontophoretic applications of the transmitters. Declines of Glu-induced activity were more frequent and profound than those of ACh-induced activity as a result of 100 presentations. Enhancements of the background activity occurred usually between the cellular responses to ACh, and its decreases were more specific during successive separate Glu presentations. The different functional roles of Glu and ACh in the dynamics of neuronal discharges in the course of learning are discussed.
Gusev
P A
PA
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D005260:Female; D005971:Glutamates / Q000008:administration & dosage / Q000494:pharmacology*; D018698:Glutamic Acid; D008905:Minicomputers; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D005971:Glutamates; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D000109:Acetylcholine
Dinamika reaktivnosti korkovykh neĭronov k povtoriaiushchemusia izolirovannomu deĭstviiu L-glutamata i atsetilkholina.