title: Autoxidation of drugs: prediction of degradation impurities from results of reaction with radical chain initiators.
abstract: In the study of the degradation of drug substances by molecular oxygen, their specific reaction mechanisms must be taken into account. The rate-determining step is usually the reaction of the substrate with a radical chain initiator, which is often an unknown impurity. The reactivity and selectivity of autoxidation can be controlled better by using a radical chain initiator, such as AIBN, than by changing the temperature or the oxygen pressure. In this paper the products profiles of four pharmaceutical substances in a simple oxidation test with AIBN are compared with the results of long term natural stability tests or with already established stabilities.
authors.affiliation: Centro Ricerche Sanofi-Midy S.p.A, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Boccardi
mesh_terms: D014151:Anti-Anxiety Agents / Q000032:analysis / Q000737:chemistry*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003915:Dextromethorphan / Q000032:analysis / Q000737:chemistry*; D004340:Drug Contamination; D009570:Nitriles; D010084:Oxidation-Reduction; D010653:Phenylbutazone / Q000032:analysis / Q000737:chemistry*; D014268:Trifluoperazine / Q000032:analysis / Q000737:chemistry*
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D009570:Nitriles; D001569:Benzodiazepines; D014268:Trifluoperazine; D003915:Dextromethorphan; C005245:tetrazepam; C004526:azobis(isobutyronitrile); D010653:Phenylbutazone