Olive oil decreases liver damage in rats caused by carbon tetrachloride (CCl4).
Oral carbon tetrachloride (CCl4) poisoning of the liver of male F-344 rats was modified by dissolving CCl4 in various oils (sunflower, corn, fish and olive). After 8 weeks of CCl4 treatment (3 x 0.2 ml/kg body weight every other day, dissolved in aliquots of 0.5 ml of each types of oil) the rats were sacrificed and the ratio of connective tissue in the liver was determined by morphometry after picrosirius staining. The percentage of collagen fibres increased in all CCl4-treated groups compared to the controls. This increase was almost the same (6-8%) in the case of CCl4 dissolved in sunflower, corn or fish oil, but when olive oil was applied as a solvent, the collagen ratio was only 2-4 percent. On the bases of this finding olive oil is considered as less harmful to the liver in acute CCl4 poisoning than other oils.
Szende
B
B
I. Institute of Pathology and Experimental Cancer Research Semmelweis University of Medicine Budapest, Hungary.
Timár
F
F
Hargitai
B
B
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000473:pathology*; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D003314:Corn Oil / Q000494:pharmacology / Q000627:therapeutic use; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D005395:Fish Oils / Q000494:pharmacology / Q000627:therapeutic use; D006368:Helianthus; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011916:Rats, Inbred F344; D000074242:Sunflower Oil; D013997:Time Factors
D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D003314:Corn Oil; D003094:Collagen