Induction of trypsin-induced hyperexcitability in the rat hippocampal slice is blocked by the N-methyl-D-aspartate receptor antagonist, MK-801.
Bath application of trypsin (0.05%, type I) gave rise to epileptiform activities in CA1 of the rat hippocampal slice. A non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, MK-801, blocked the induction of the epileptiform activity, whereas a competitive antagonist, D-APV, showed weak antagonism on the induction of the epileptiform activity. These results may lead us to the understanding of the role of NMDA receptors in the neurotoxic action of trypsin.
Yamada
N
N
Department of Psychology, University of Otago, Dunedin, New Zealand.
Bilkey
D K
DK
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004594:Electrophysiology; D004827:Epilepsy / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D014357:Trypsin / Q000494:pharmacology*
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D015763:2-Amino-5-phosphonovalerate; D014357:Trypsin