Effects of Z-300, a new histamine H2-receptor antagonist, on mucin biosynthesis in rat gastric mucosa.
We examined the effects of Z-300 (N-[3-[3- (piperidinomethyl)phenoxy]propyl]-2-(2-hydroxy-ethyl-1-thio)acetam ido.2- (4-hydroxy benzoyl)benzoate), a newly-synthesized selective histamine H2-receptor antagonist, on mucin in rat gastric mucosa. Deep corpus mucin content increased significantly to 127% of the control after the administration of 30 mg/kg of Z-300, whereas that in the antral mucosa did not increase. The addition of Z-300 significantly increased [3H]-labeled mucin in the corpus region. In the antrum, biosynthetic activity showed no significant change by 10(-8)-10(-5) M of Z-300. These results suggest that Z-300 not only inhibits acid secretion but may also promote gastric mucus metabolism in the corpus region.
Ichikawa
T
T
Department of Biochemistry, Kitasato University School of Medicine, Kanagawa, Japan.
Ishihara
K
K
Ogata
Y
Y
Ohara
S
S
Saigenji
K
K
Hotta
K
K
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005944:Glucosamine / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D009077:Mucins / Q000096:biosynthesis*; D009924:Organ Culture Techniques; D010880:Piperidines / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000081:Acetamides; D006635:Histamine H2 Antagonists; D009077:Mucins; D010880:Piperidines; C077871:Z 300; D011899:Ranitidine; D005944:Glucosamine