title: Hodgkin's disease presenting as a solitary thyroid nodule.
abstract: Two patients with unusual Hodgkin's disease who initially had a painless, solitary, thyroid cold nodule are described. Fine-needle aspiration revealed lymphocytic thyroiditis in one patient and a diagnosis of Hodgkin's disease was made 1 year later. In the second patient, aspiration of the nodule demonstrated a syncytial variant of nodular sclerosis Hodgkin's disease. Both patients underwent radiologic work-up, and surgery of the thyroid was avoided. After chemotherapy, both thyroid nodules disappeared. Thyroid involvement by Hodgkin's disease may be more common than anticipated, and may present atypically as a solitary thyroid nodule. Lymphocytic thyroiditis may accompany the disease and may cause a delay in the diagnosis. Recognition of this entity and the use of fine-needle aspiration may prevent unnecessary thyroid surgery, thus maintaining intact thyroid function after therapy.
authors.affiliation: Department of Nuclear Medicine, Carmel Medical Center, Haifa, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Hardoff
authors.forename: R
authors.initials: R
authors.lastname: Bar-Shalom
authors.forename: M
authors.initials: M
authors.lastname: Dharan
authors.forename: R
authors.initials: R
authors.lastname: Luboshitsky
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D011877:Radionuclide Imaging; D016606:Thyroid Nodule / Q000209:etiology* / Q000628:therapy