Comparison of renal function parameters in the assessment of cis-platin induced nephrotoxicity.
The early renal function parameters (RFP), i.e. urinary alanine aminopeptidase (AAP), beta-galactosidase (beta GAL), N-acetyl-beta-D-glucosaminidase (NAG), retinol-binding protein (RBP), albumin (ALB), total protein (TP) and the conventional RFP plasma creatinine were assessed in 8 patients before and during treatment with the nephrotoxic antitumor agent cis-platin. Plasma creatinine increased during treatment with cis-platin. In all patients, acute tubular damage was revealed by early RFP. Albumin and total protein excretion patterns suggested alterations in glomerular function. The cumulative change in RBP excretion was related to plasma creatinine concentrations following cis-platin administration. The present study demonstrates that urinary RBP is a valuable parameter for the early assessment of cis-platin-induced nephrotoxicity.
Verplanke
A J
AJ
Coronel Laboratory for Occupational and Environmental Health, University of Amsterdam, The Netherlands.
Herber
R F
RF
de Wit
R
R
Veenhof
C H
CH
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000419:Albuminuria / Q000139:chemically induced / Q000201:enzymology / Q000652:urine; D000626:Aminopeptidases / Q000652:urine; D018826:CD13 Antigens; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000652:urine*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D011507:Proteinuria / Q000139:chemically induced / Q000201:enzymology / Q000652:urine; D012177:Retinol-Binding Proteins / Q000652:urine; D054839:Retinol-Binding Proteins, Plasma; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D001616:beta-Galactosidase / Q000652:urine
D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D003404:Creatinine; D001616:beta-Galactosidase; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens; D002945:Cisplatin