Class II major histocompatibility complex molecule expression on murine eosinophils activated in vivo by Brugia malayi.
The Th-2 response to microfilariae of Brugia malayi in BALB/c mice is associated with peritoneal eosinophilia. These eosinophils had an activated hypodense phenotype in vivo and expressed high levels of the class II major histocompatibility complex (MHC). Interleukin 4 up-regulated the class II MHC, whereas gamma interferon inhibited class II MHC expression on eosinophils.
Mawhorter
S D
SD
Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4984.
Pearlman
E
E
Kazura
J W
JW
Boom
W H
WH
D000818:Animals; D017178:Brugia malayi / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004804:Eosinophils / Q000276:immunology*; D005368:Filariasis / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D007371:Interferon-gamma / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D015848:Interleukin-5 / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008842:Microfilariae / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D015848:Interleukin-5; D015847:Interleukin-4; D007371:Interferon-gamma