Somatostatin and the immune and haematopoetic system; a review.
SS-R and SS have been demonstrated in non-pathological and pathological lymphoid tissue and may play a regulatory, mostly inhibitory, role in the immune response. SS is produced by lymphocytes and monocytes which suggests an autocrine or paracrine regulatory role, but SS may be released as well by nerve endings. It can therefore be hypothesized that apart from a role of SS in local, immunomodulation of cells belonging to the immune system, a second pathway exists in which this peptide exerts its effects via neuroendocrine modulation of the immune response which might represent a direct regulatory relation between the nervous and the immune system. The presence of SS-R in lymphoid neoplasm cells and in diseases involving activated mononuclear leukocytes allows the visualization of these diseases using octreotide scintigraphy. This technique may be used in the evaluation of the spread of these diseases and to monitor their response to therapy. Moreover, the presence of SS-R in immune diseases warrants studies on the efficacy of treatment with octreotide of patients suffering from these diseases.
van Hagen
P M
PM
Department of Internal Medicine III, University Hospital Rotterdam, The Netherlands.
Krenning
E P
EP
Kwekkeboom
D J
DJ
Reubi
J C
JC
Anker-Lugtenburg
P J
PJ
Löwenberg
B
B
Lamberts
S W
SW
D000818:Animals; D006413:Hematopoietic System / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology; D017481:Receptors, Somatostatin / Q000032:analysis; D013004:Somatostatin / Q000502:physiology*
D017481:Receptors, Somatostatin; D013004:Somatostatin