A new alpha 1-adrenergic receptor subtype with low affinity for 5-methyl-urapidil but insensitive to chlorethylclonidine.
In the present study, we found that a novel alpha 1-adrenergic receptor subtype existed in rat heart by radioligand binding assay. This new alpha 1-adrenergic receptor subtype was different from alpha 1A-, alpha 1B-, alpha 1C-, and alpha 1D-subtypes reported recently. It had high affinity for WB4101, as the same of alpha 1A-subtype, but low affinity for 5-methyl-urapidil, and was insensitive to chlorethylclonidine.
Yu
G S
GS
Institute of Vascular Medicine, Third Hospital, Beijing Medical University, China.
Han
Q D
QD
Chen
M Z
MZ
D000317:Adrenergic alpha-Antagonists / Q000378:metabolism / Q000494:pharmacology; D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004146:Dioxanes / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010627:Phenethylamines / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000145:classification / Q000378:metabolism*; D044024:Tetralones
D000317:Adrenergic alpha-Antagonists; D000477:Alkylating Agents; D004146:Dioxanes; D010627:Phenethylamines; D010879:Piperazines; D018340:Receptors, Adrenergic, alpha-1; D044024:Tetralones; C057446:5-methylurapidil; C051731:chlorethylclonidine; C010652:BE 2254; C010654:(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane; D003000:Clonidine