Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.
The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally inherited in each, and shows a strong association with atopy. Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q.
Shirakawa
T
T
Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK.
Li
A
A
Dubowitz
M
M
Dekker
J W
JW
Shaw
A E
AE
Faux
J A
JA
Ra
C
C
Cookson
W O
WO
Hopkin
J M
JM
D000595:Amino Acid Sequence; D001483:Base Sequence; D002880:Chromosomes, Human, Pair 11; D004247:DNA / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D010641:Phenotype; D016133:Polymerase Chain Reaction; D017455:Receptors, IgE / Q000737:chemistry / Q000235:genetics*
D017455:Receptors, IgE; D004247:DNA