title: Changes in human papillomavirus typing of recurrent respiratory papillomatosis progressing to malignant neoplasm.
abstract: A patient with recurrent respiratory papillomatosis progressed spontaneously to carcinoma resulting in death. Serial biopsy specimens obtained during a 9-year course of this patient's disease were tested via polymerase-chain reaction and Southern hybridization to detect the human papillomavirus (HPV) types present during the patient's course of disease. Early biopsy specimens were positive for HPV types 6 and 11. As atypia progressed to carcinoma, HPV types 6 and 11 remained present, but the signal decreased and HPV 16 became increasingly positive. The significance of these findings will be discussed.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tulane Medical School, New Orleans, La.
authors.forename: D J
authors.initials: DJ
authors.lastname: Doyle
authors.forename: L A
authors.initials: LA
authors.lastname: Henderson
authors.forename: F E
authors.initials: FE
authors.lastname: LeJeune
authors.forename: R H
authors.initials: RH
authors.lastname: Miller
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D002471:Cell Transformation, Neoplastic; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000821:virology*; D008297:Male; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000473:pathology / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000473:pathology*; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000473:pathology*