title: Familial vasculitis: report of 2 families.
abstract: We observed systematic vasculitis (polyarteritis nodosa and Wegener's granulomatosis) in several members of 2 different families. Our experience and a review of the literature suggests that genetic factors are important but not sufficient to express clinical features of these diseases.
authors.affiliation: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD.
authors.forename: M
authors.initials: M
authors.lastname: Rottem
authors.forename: M F
authors.initials: MF
authors.lastname: Cotch
authors.forename: A S
authors.initials: AS
authors.lastname: Fauci
authors.forename: G S
authors.initials: GS
authors.lastname: Hoffman
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010488:Polyarteritis Nodosa / Q000188:drug therapy / Q000235:genetics*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D003520:Cyclophosphamide; D001379:Azathioprine; D011241:Prednisone