[Effects of sodium succinate on functional, biochemical and morphological indicators of CNS repair in rats after 10-minute circulation arrest].
Therapeutic effect of sodium succinate on various functional, biochemical, and morphological parameters of CNS repair was studied in experiments on rats exposed to 10-min circulation arrest. The first series of experiments was devoted to studies of the effects of the drug, injected intraperitoneally directly after recovery of effective cardiac activity and during the subsequent 5 days in doses 20, 100, and 200 mg/kg, on the survival and recovery of the external neurologic status. The dose of 20 mg/kg proved to be the most effective. The second series of experiments was devoted to therapeutic effect of sodium succinate in the same dose injected from day 3 to day 7 after revival on the orientation and investigation behaviour in an "open field" test, on changes in radical formation in the blood serum and the brain, and on the cholesterol/lipid ratio in the brain, as well as on the morphologic changes in the cerebral hemispheres and the cerebellum. In contrast to untreated animals, the treated ones had a less intensive reaction in the "open field" test in response to acute stressor exposure, their cerebral and blood serum levels of free radical processes were reduced, the destruction of neuronal membranous elements was less intensive, as were dystrophic changes in the cerebral cortex and the cerebellum. The data permit a conclusion about antistressor and protective effect of sodium succinate in the postresuscitation period at the functional, biochemical, and morphological levels.
Zarzhetskiĭ
Iu V
IuV
Mutuskina
E A
EA
Trubina
I E
IE
Avrushchenko
M Sh
MSh
Onufriev
M V
MV
Mikhalev
S L
SL
Guliaeva
N V
NV
Gurvich
A M
AM
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D002531:Cerebellum / Q000187:drug effects / Q000473:pathology; D002540:Cerebral Cortex / Q000187:drug effects; D005609:Free Radicals; D006323:Heart Arrest / Q000473:pathology / Q000628:therapy*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D012151:Resuscitation; D013386:Succinates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019802:Succinic Acid; D013997:Time Factors
D005609:Free Radicals; D013386:Succinates; D019802:Succinic Acid
Vliianie suktsinata natriia na funktsional'nye, biokhimicheskie i morfologicheskie pokazateli vosstanovleniia TsNS u krys posle 10-minutnoĭ ostanovki krovoobrashcheniia.