title: Case report: the effect of a Chinese herbal medicine, BG-104 in two HIV positive hemophiliacs.
abstract: The BG-104, a Chinese herbal medicine, has been reported to restore decreased plasma superoxide scavenging activity. This report showed in vivo effect of BG-104 on two patients with hemophilia A infected with human immunodeficiency virus by infusions of the concentrated Factor VIII. Both patients, showed a peripheral CD4+ T-lymphocytopenia for more than half a year. BG-104 was administered daily and follow-up observations were continued for 3 years. The number of CD4+ T-lymphocytes remained relatively constant during BG-104 treatment without disease progression.
authors.affiliation: Tokai University Medical and Health Care Administration Center, Isehara, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Arimori
authors.forename: H
authors.initials: H
authors.lastname: Nozaki
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Arimori
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes; D016827:CD8 Antigens / Q000032:analysis; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005434:Flow Cytometry; D005500:Follow-Up Studies; D016166:Free Radical Scavengers; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy*; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000517:prevention & control
chemical_list: D000975:Antioxidants; D016827:CD8 Antigens; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; C065720:BG 104