title: Cholinesterase inhibition by vecuronium and pancuronium in human airways.
abstract: Vecuronium (100 microM) but not pancuronium (100 microM) increased the sensitivity of human isolated bronchial preparations (HBP) to exogenous acetylcholine (ACh). The pD2 values obtained from concentration-dependent contractions were: control, 4.59 +/- 0.29 vecuronium, 5.86 +/- 0.31. Vecuronium or pancuronium (100 microM) significantly decreased (50%) the neostigmine contractions in HBP. In addition, vecuronium was more potent than pancuronium in preventing exogenous ACh degradation. These results suggest that vecuronium and pancuronium may have physiological effects in human airways by inhibiting both the tissue cholinesterases and muscarinic (M3) receptors.
authors.affiliation: CNRS URA 1159, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, France.
authors.forename: X
authors.initials: X
authors.lastname: Norel
authors.forename: C
authors.initials: C
authors.lastname: Labat
authors.forename: D
authors.initials: D
authors.lastname: De Santis
authors.forename: I
authors.initials: I
authors.lastname: Gorenne
authors.forename: E
authors.initials: E
authors.lastname: Dulmet
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Brink
mesh_terms: D001980:Bronchi / Q000187:drug effects* / Q000201:enzymology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000201:enzymology; D010197:Pancuronium / Q000494:pharmacology*; D014673:Vecuronium Bromide / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D014673:Vecuronium Bromide; D002802:Cholinesterases; D010197:Pancuronium