title: [4P- syndrome (Wolf-Hirschhorn syndrome) complicated with delay onset of malignant hyperthermia: a case report].
abstract: One 8-month-old female patient, weighted 5 kg, with congenital abnormality (4P- syndrome) underwent elective cheiloplasty for cleft lip and palate. Two hours later, with smooth anesthesia and operation, a life-threatening anesthetic complication of malignant hyperthermia occurred at pediatric intensive care unit. The immediate treatments were initially hyperventilating the patient with 100% O2 and cooling the patient with ice bags. Subsequently, intravenous dantrolene 2.5 mg/kg and symptomatic supportive care were administered successfully to treat the event. Upon reviewing the articles, we found that a congenital chromosome 4P deletion abnormality complicated with a delay onset of malignant hyperthermia has not been described previously.
authors.affiliation: Department of Anesthesiology, Mackay Memorial Hospital, Taipei.
authors.forename: J C
authors.initials: JC
authors.lastname: Chen
authors.forename: R K
authors.initials: RK
authors.lastname: Jen
authors.forename: Y W
authors.initials: YW
authors.lastname: Hsu
authors.forename: Y B
authors.initials: YB
authors.lastname: Ke
authors.forename: J J
authors.initials: JJ
authors.lastname: Hwang
authors.forename: K H
authors.initials: KH
authors.lastname: Wu
authors.forename: T T
authors.initials: TT
authors.lastname: Wei
mesh_terms: D002869:Chromosome Aberrations; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D007223:Infant; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D013577:Syndrome