[Etiology of affective disorders].
We discussed mainly neurochemical etiology of affective disorders (A.D.). Neurochemically, decreased 5-HT uptake in the platelet, increased 5-HT2 receptor in the platelet and cortex of suicides, increased beta receptor in the brains of suicide, functional abnormality of alpha 2 receptor in clonidine, DMI test, GABAB receptor up-regulation after chronic administration of antidepressants and mood stabilizers, participation of neuropeptide Y, and abnormality of HPA axis were recognized. Moreover, we referred to the importance of psychosocial and genetic factors. As for the etiology of A.D., while predisposition and environment participate, the method of participation will be different in subtypes. Frailty to stress in a broad sense, however is commonly seen in A.D. Though psychosocial factors are important, the physical condition, which involves fatigue, cannot be ignored. And, it is the most important that the biological and genetical factors which cause A.D., in the face of stimuli, must first be elucidated.
Shinohara
M
M
Department of Neuropsychiatry, Yamanashi Medical University.
Kariya
T
T
D000818:Animals; D006801:Humans; D019964:Mood Disorders / Q000209:etiology* / Q000378:metabolism; D009479:Neuropeptides / Q000502:physiology; D009490:Neurosecretory Systems / Q000378:metabolism / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D009479:Neuropeptides; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid