The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation.
The Drosophila anachronism (ana) locus controls the proliferation of neuroblasts, neuronal stem cells that give rise to the central nervous system. In ana mutants, quiescent postembryonic central brain and optic lobe neuroblasts enter S phase precociously. ana encodes a novel secreted protein of 474 amino acids that is expressed not in the affected neuroblasts, but rather in a subclass of neighboring glial cells. These studies argue for an important role for glia in negatively regulating proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis.
Ebens
A J
AJ
Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, School of Medicine, Los Angeles 90024-1737.
Garren
H
H
Cheyette
B N
BN
Zipursky
S L
SL
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D004252:DNA Mutational Analysis; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D006023:Glycoproteins / Q000235:genetics* / Q000494:pharmacology; D008969:Molecular Sequence Data; D009154:Mutation; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects; D013234:Stem Cells / Q000187:drug effects
D029721:Drosophila Proteins; D006023:Glycoproteins; C082255:ana protein, Drosophila