Anaphylaxis to cisplatin: diagnosis and value of pretreatment in prevention of recurrent allergic reactions.
Two patients, who developed anaphylaxis to cisplatin, are described. This phenomenon was preceded by mild allergic symptoms, which were overlooked, in previous treatment courses. Intradermal skin tests were both sensitive and specific in the diagnosis of cisplatin allergy. Pretreatment with antihistamines and corticosteroids was ineffective in preventing recurrent anaphylaxis. Thus, a trial of desensitization is mandatory among those patients whose disease responds to the administration of this agent.
Goldberg
A
A
Allergy and Clinical Immunology Unit, Sapir Medical Center, Kfar Saba, Israel.
Altaras
M M
MM
Mekori
Y A
YA
Beyth
Y
Y
Confino-Cohen
R
R
D000230:Adenocarcinoma / Q000188:drug therapy; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000517:prevention & control; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012008:Recurrence; D012882:Skin Tests
D000305:Adrenal Cortex Hormones; D006634:Histamine H1 Antagonists; D002945:Cisplatin