[The pharmacokinetic characteristics of fenazepam in epileptics].
Testing the injectable dosage form of phenazepam showed no substantial pharmacokinetic differences in epileptic patients receiving a single intravenous and intramuscular doses of 2 mg. The bioavailability of the drug was 0.82. The individual and mean experimental stationary phenazepam concentration (157.3 ng/ml) in the patients' blood during course intramuscular therapy was found to be close to the theoretical stationary one (150.6 ng/ml). The pharmacokinetic findings allow one to optimize phenazepam therapy for epileptic patients.
Maksutova
E L
EL
Sariev
A K
AK
Zherdev
V P
VP
Voronina
T A
TA
Zheleznova
E V
EV
D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D004827:Epilepsy / Q000097:blood*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
Farmakokineticheskie kharakteristiki fenazepama u bol'nykh épilepsieĭ.