title: Immunohistochemical study of basic fibroblast growth factor and erythropoietin in cerebellar hemangioblastomas.
abstract: This report deals with immunohistochemical studies performed on 21 cases of cerebellar hemangioblastomas. Antibodies against basic fibroblast growth factor, glial fibrillary acidic protein, vimentin, factor VIII, and erythropoietin were used. A considerable number of stromal cells and some endothelial cells were positive for basic fibroblast growth factor in all cases studied. The stromal cells of four cases were positive for erythropoietin; two of these cases were associated with secondary polycythemia. Our data suggest that basic fibroblast growth factor may contribute to angiogenesis in cerebellar hemangioblastomas.
authors.affiliation: Department of Neurosurgery, School of Medicine, Kanazawa University.
authors.forename: O
authors.initials: O
authors.lastname: Tachibana
authors.forename: T
authors.initials: T
authors.lastname: Yamashima
authors.forename: J
authors.initials: J
authors.lastname: Yamashita
authors.forename: K
authors.initials: K
authors.lastname: Takinami
mesh_terms: D000293:Adolescent; D000328:Adult; D002528:Cerebellar Neoplasms / Q000473:pathology*; D004921:Erythropoietin / Q000032:analysis*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D018325:Hemangioblastoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
chemical_list: D016222:Fibroblast Growth Factor 2; D004921:Erythropoietin