title: Combined antiinfluenza activity of a plant preparation SHS-174 and amantadine derivatives.
abstract: The results of the study on the combined antiviral activity of the SHS-174 preparation (a lyophylized infusion from three higher plants) and three amantadine derivatives (rimantadine, amantadine glucuronide and its derivative) are presented. The antiviral effect of the drugs on the reproduction of influenza virus strains A/H1N1 and A/H3N2 in vitro was studied. The combined antiviral effect was evaluated on the basis of viral yields and in many cases a synergism was found. The most synergistic effect was shown for the combination of SHS-174 with the derivative of amantadine glucuronide.
authors.affiliation: Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.
authors.forename: J
authors.initials: J
authors.lastname: Serkedjieva
authors.forename: I
authors.initials: I
authors.lastname: Zgorniak-Nowosielska
mesh_terms: D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002642:Chick Embryo; D004347:Drug Interactions; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D012299:Rimantadine / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects* / Q000502:physiology
chemical_list: D010936:Plant Extracts; D012299:Rimantadine; D000547:Amantadine