Assay of serum interleukin 8 levels in patients with alcoholic hepatitis.
Studies were performed to evaluate the role of interleukin 8 (IL-8) in the pathogenesis of alcoholic hepatitis. Using a recently developed sensitive and specific enzyme-linked immunosorbent assay, we measured serum IL-8 levels in patients with alcoholic hepatitis. The mean serum IL-8 level was increased significantly in patients with alcoholic hepatitis compared with normal controls (P < 0.05). It was of interest to note that serum IL-8 levels were increased transiently after abstinence from alcohol in patients with alcoholic hepatitis. These findings suggest that there may be a correlation between IL-8 and alcoholic hepatitis.
Masumoto
T
T
Third Department of Internal Medicine, Ehime University School of Medicine, Japan.
Onji
M
M
Horiike
N
N
Ohta
Y
Y
D000328:Adult; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006519:Hepatitis, Alcoholic / Q000097:blood*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000097:blood
D015415:Biomarkers; D016209:Interleukin-8; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D001663:Bilirubin