title: Experimental MR study of cerebral radiation injury: quantitative T2 changes over time and histopathologic correlation.
abstract: OBJECTIVE
  To use the pig brain as a large-animal model to examine the effects of high-dose single-fraction irradiation on MR images, T2 relaxation time, and histologic integrity.
  
  
  METHODS
  A total of 24 Meishan pigs were studied: 20 irradiated animals and 4 unirradiated controls. A high dose was delivered to the right hemisphere of the animals, using a 12-MeV electron beam. Ten animals received 40 Gy at the 90% isodose, and 10 animals received 60 Gy. Quantitative measurement of T2 relaxation time was compared with qualitative analysis of T2-weighted images and histologic studies.
  
  
  RESULTS
  Quantitative analysis revealed a reproducible increase of the T2 parameter within the irradiated areas. The T2 kinetic could be analyzed in two phases, which appeared before the visualization of ventricle compression, necrosis, and edema. The first is characterized by vascular inflammation and the latter by radiation necrosis and edema. Both are dose dependent.
  
  
  CONCLUSIONS
  These results underline the ability of quantitative MR for early diagnosis of brain radiation lesions in vivo.
authors.affiliation: Laboratoire de Biophysique Cellulaire et RMN, Institut National de la Santé et de la Recherche Medicale, Tours, France.
authors.forename: E
authors.initials: E
authors.lastname: Miot
authors.forename: D
authors.initials: D
authors.lastname: Hoffschir
authors.forename: C
authors.initials: C
authors.lastname: Alapetite
authors.forename: G
authors.initials: G
authors.lastname: Gaboriaud
authors.forename: D
authors.initials: D
authors.lastname: Pontvert
authors.forename: F
authors.initials: F
authors.lastname: Fetissof
authors.forename: A
authors.initials: A
authors.lastname: Le Pape
authors.forename: S
authors.initials: S
authors.lastname: Akoka
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000528:radiation effects*; D001927:Brain Diseases / Q000473:pathology; D001929:Brain Edema / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology / Q000528:radiation effects; D003711:Demyelinating Diseases / Q000473:pathology; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D004730:Endothelium, Vascular / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D015203:Reproducibility of Results; D013552:Swine; D013997:Time Factors; D014657:Vasculitis / Q000473:pathology