[Rapidly progressive kidney failure associated with neutrophil anticytoplasmic autoantibodies. Anatomo-clinical case].
We report a 63 year old woman with a rapidly progressive renal failure and fever of unknown origin. Laboratory tests showed anemia, increased ESR and a urine analysis compatible with a glomerular disease. Antineutrophil cytoplasmic autoantibodies were positive with a perinuclear pattern. Kidney biopsy showed an autoimmune crescenteric glomerulonephritis. The patient had a bad evolution, dying after a massive hemoptysis. The necropsy showed a disseminated arteritis without compromise of bronchial vessels. The oligosymptomatic presentation of this patient, bearing in mind the anatomo-pathological findings, is noteworthy and emphasizes the usefulness of serological markers as antineutrophil cytoplasmic autoantibodies in the differential diagnosis.
Wainstein
E
E
Servicio de Medicina, Facultad de Medicina, Universidad de Chile.
Puelma
A
A
Carrasco
A M
AM
Guzmán
L
L
D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology; D001323:Autoantibodies / Q000032:analysis*; D003593:Cytoplasm / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010488:Polyarteritis Nodosa / Q000473:pathology; D014657:Vasculitis / Q000150:complications
D001323:Autoantibodies
Insuficiencia renal rápidamente progresiva asociada a anticuerpos anticitoplasmáticos de neutrófilos. Caso anátomo clínico.