The selective D2 dopamine receptor antagonist eticlopride counteracts the ejaculatio praecox induced by the selective D2 dopamine agonist SND 919 in the rat.
The selective D2 antagonist eticlopride, at a dose (0.01 mg/kg, s.c.) that fails to modify the normal behavior of rats, significantly reversed all the behavioral effects exerted by the selective D2 agonist SND 919 (0.1 mg/kg, i.p.), namely, the stimulation of stretching-yawning, penile erection and sedation and the inhibition of grooming. In the copulatory test, eticlopride at the same dose did not affect animal sexual behavior but potently counteracted the reduction in mount and intromission frequency and latency to ejaculation induced by SND 919 at 0.1 mg/kg, a behavioral pattern which might possibly be proposed as an animal model for human ejaculatio praecox.
Ferrari
F
F
Department of Biomedical Sciences, University of Modena, Italy.
Giuliani
D
D
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D052160:Benzothiazoles; D003307:Copulation / Q000187:drug effects; D015259:Dopamine Agents / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004542:Ejaculation / Q000187:drug effects*; D005260:Female; D008297:Male; D000077487:Pramipexole; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000502:physiology*; D012457:Salicylamides / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy*; D013844:Thiazoles / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
D052160:Benzothiazoles; D015259:Dopamine Agents; D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D012457:Salicylamides; D013844:Thiazoles; D000077487:Pramipexole; C045989:eticlopride