Labetalol overdose successfully treated with amrinone and alpha-adrenergic receptor agonists.
Circulatory collapse and obtundation occurred in a 37-year-old woman following an iatrogenic overdose of labetalol. Conventional therapy with glucagon and alpha-adrenergic receptor-stimulating agents was ineffective in raising the patient's cardiac output or improving her mental status despite increasing the arterial pressure. The administration of amrinone was temporally associated with significant increases in the cardiac output accompanied by improved mental status. This case suggests that amrinone may be effective adjunctive therapy for beta-adrenergic receptor blocker overdoses by reversing their negative inotropic effects.
Kollef
M H
MH
Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110.
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D000676:Amrinone / Q000627:therapeutic use*; D002303:Cardiac Output, Low / Q000139:chemically induced / Q000188:drug therapy; D062787:Drug Overdose / Q000188:drug therapy; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D007741:Labetalol / Q000506:poisoning*; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D012769:Shock / Q000188:drug therapy; D016277:Ventricular Function, Left / Q000187:drug effects
D000316:Adrenergic alpha-Agonists; D000676:Amrinone; D007741:Labetalol