[Alteration of dynorphin1-8 and leu-enkephalin in rat hippocampus during seizure and electroacupuncture].
Immunocytochemical technics were used to evaluate the influence of penicillin-induced seizure and electroacupuncture treatment on dynorphin1-8 and leu-enkephalin immunoreactivity in hippocampus. It was found that 3 h after beginning of seizure there started a dramatic decrease in dynorphin1-8 in hilus, mossy fiber of hippocampus but an increase in hilus, mossy fiber of hippocampus but an increase in leu-enkephalin in subiculum, CA1 area of hippocampus and some other limbic structures. Electroacupuncture treatment decreased the leu-enkephalin immunoreactivity in the nuclei mentioned above and increased dynorphin1-8 immunoreactivity in hippocampus. The results show that epileptiform activity and electroacupuncture inhibitory effect on seizure may be related to the alteration of dynorphin1-8 and leu-enkephalin in the brain.
Wang
B E
BE
Department of Neurobiology, Shanghai Medical University, National Laboratory of Medical Neurobiology, China.
Cheng
J S
JS
D000818:Animals; D004399:Dynorphins / Q000378:metabolism*; D015671:Electroacupuncture; D004743:Enkephalin, Leucine / Q000378:metabolism*; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D010406:Penicillins; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D010406:Penicillins; D010446:Peptide Fragments; D004743:Enkephalin, Leucine; D004399:Dynorphins; C026770:dynorphin (1-8)