[Detection of somatostatin receptors in tumors in the area of the head and neck and their clinical importance].
The development of a radiolabelled somatostatin analogue Indium-111-Pentetreotide makes the detection of somatostatin receptor-bearing tumours by scintigraphic techniques possible. The existence of high-affinity binding sites for somatostatin has been described previously for most endocrine active tumours of the gastroenteropancreatic system (GEP), malignant lymphomas, small cell lung carcinomas, a subgroup of breast tumours and several types of neuroendocrine related human tumours. Using this new diagnostic tool we investigated some head and neck tumours of neuroendocrine origin (carcinoid of larynx, Merkel cell carcinoma, paragangliomas) with the newly developed radiolabelled somatostatin analogue Indium-111-Pentetreotide whether in vivo visualisation of somatostatin receptors might be possible. In cases not accessible for surgery but with a positive receptor status we started a specific therapy with the somatostatin analogue octreotide. The preliminary results suggest that this new isotopic scanning technique in a diagnostic tool and a predictive method for an effective therapy of those head and neck tumours which revealed highly specifically a positive receptor status. The therapeutical results using the somatostatin analogue octreotide indicate that this new concept is an ideal therapeutic strategy for those neuroendocrine head and neck tumours which cannot be controlled by surgical procedures.
Kau
R J
RJ
Hals-Nasen-Ohren-Klinik, Technischen Universität München, Klinikum rechts der Isar.
Wagner-Manslau
C
C
Saumweber
D M
DM
Arnold
W
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D015266:Carcinoma, Merkel Cell / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D002345:Carotid Body Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005918:Glomus Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007205:Indium Radioisotopes; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000032:analysis* / Q000187:drug effects / Q000502:physiology; D013004:Somatostatin / Q000031:analogs & derivatives
D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D013004:Somatostatin; C081788:pentetreotide; D015282:Octreotide
Nachweis von Somatostatinrezeptoren in Tumoren des Kopf-Hals-Bereiches und ihre klinische Bedeutung.