[Determination of tetramethylpyrazine and borneol in human plasma by GC-MSD].
A GC-MSD method for the determination of tetramethylpyrazine (TMP) and borneol in plasma is described. TMP and borneol were extracted with hexane-dichloromethane (10:1, V/V). Camphor was used as the internal standard. The average recoveries of TMP and borneol were 87.38% and 97.32% with relative standard deviation 1.90% to 6.21%, respectively. The method was successfully used to determine plasma borneol concentration following sublingual administration of 20 pills of Suxiao Jiuxin Wan to healthy volunteers (n = 10). The pharmacokinetic parameters have been listed in this paper.
Yang
L L
LL
Department of Instrumental Analysis, Nanjing General Hospital of Nanjing Command.
Yuan
Y S
YS
Tong
Y L
YL
Guo
C Y
CY
D000328:Adult; D000818:Animals; D001892:Camphanes / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D011719:Pyrazines / Q000097:blood*; D011817:Rabbits
D001892:Camphanes; D011719:Pyrazines; C022871:isoborneol; C017953:tetramethylpyrazine