The biological background of refractory schizophrenia: a study on clinical states, serum drug concentration, cognitive function and brain CT findings.
Inpatients who had been in the hospital for more than three years (refractory group, n = 53) were compared with outpatients who had not been admitted to the hospital in the last three years (remission group, n = 42). There were differences between the two groups in "blunted affect-thought disturbance" symptoms, "hallucination-delusion" symptoms, the score of behavior rating scale (BRS), the dosage and serum concentration of antipsychotics, the score of Hasegawa's Dementia Scale (HDS) and brain CT findings. "Blunted affect-thought disturbance" symptoms were strongly related to the BRS score, the dosage of antipsychotics and the HDS score. Sylvian fissures enlargement was related to "blunted affect-thought disturbance" symptoms. Sylvian fissures enlargement was thought to be a biological background of refractory schizophrenia.
Hori
A
A
Department of Psychiatry, National Center of Neurology and Psychiatry, Kodaira.
Nagayama
M
M
Shimada
H
H
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000503:physiopathology* / Q000523:psychology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents