title: Time to discontinue the use of solutions A and B as a cyanide 'antidote'.
abstract: Solutions A and B (15.8% ferrous sulfate in 0.3% citric acid and 6% sodium carbonate, respectively) have been available as a first-aid treatment for cyanide ingestion for many decades. Controversy surrounding the efficacy of solutions A and B has existed for much of that time, the main protagonists being in the UK. The current opinion in the UK is that solutions A and B should no longer be used as a first-aid measure in the management of cyanide poisoning. Similarly, oral sodium thiosulfate or activated charcoal should not be used. The recommended first-aid treatment of symptomatic cyanide poisoning is 100% oxygen and amyl nitrite, irrespective of the route of exposure.
authors.affiliation: ICI Chemicals & Polymers Ltd, Billingham, Cleveland, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Nicholson
authors.forename: J
authors.initials: J
authors.lastname: Ferguson-Smith
authors.forename: M A
authors.initials: MA
authors.lastname: Pemberton
authors.forename: A
authors.initials: A
authors.lastname: Campbell
authors.forename: J N
authors.initials: JN
authors.lastname: Edwards
authors.forename: R E
authors.initials: RE
authors.lastname: Ferner
mesh_terms: D000931:Antidotes / Q000627:therapeutic use*; D002254:Carbonates / Q000627:therapeutic use*; D003486:Cyanides / Q000506:poisoning*; D005296:Ferrous Compounds / Q000627:therapeutic use*; D006801:Humans; D009784:Occupational Diseases / Q000188:drug therapy*
chemical_list: D000931:Antidotes; D002254:Carbonates; D003486:Cyanides; D005296:Ferrous Compounds; C020748:ferrous sulfate; C005686:sodium carbonate