Coronary artery operation supported by the Hemopump: an experimental study on pig.
Twelve pigs undergoing coronary artery bypass grafting had the Hemopump to decompress the heart and as circulatory support. The pigs also were given a short-acting beta-blocker, esmolol, to make the heart flaccid. Extracorporeal circulation was not used. During Hemopump support, a bolus dose of 0.5 to 5 mg/kg of esmolol was given before incremental titration steps from 100 to 600 micrograms.kg-1.min-1 over 15 to 20 minutes. The internal thoracic artery was sutured to the distal part of the left anterior descending artery. The Hemopump was withdrawn to the aorta after a weaning period of 20 to 30 minutes. Seven of 12 pigs went through the whole procedure and the Hemopump was weaned off without complications. Five animals died due to right ventricular failure in association with esmolol administration. There was a big interindividual difference in esmolol dose-response curves in the surviving animals. No significant differences in the hemodynamic variables were observed during the experiment. The Hemopump in combination with a short-acting beta-blocker could be an alternate way of performing coronary artery bypass grafting in selected patients.
Lönn
U
U
Linköping Heart Center, University of Linköping, Sweden.
Peterzén
B
B
Granfeldt
H
H
Casimir-Ahn
H
H
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001026:Coronary Artery Bypass; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D006353:Heart-Assist Devices; D006439:Hemodynamics; D011412:Propanolamines / Q000008:administration & dosage / Q000494:pharmacology; D013552:Swine
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol