title: Nodular lymphocyte predominance Hodgkin's disease featuring blood atypical polyclonal B-cell lymphocytosis.
abstract: The nodular lymphocyte predominance form of Hodgkin's disease (NLPHD) is considered as a B cell derived lymphoproliferative disease. A patient with NLPHD presented with an absolute increase in blood B cells with cytological features of mantle zone cells; these B cells were polyclonal, did not exhibit bcl-2 gene rearrangement, and some of them displayed non-clonal chromosomal aberrations. EB virus genome was not detected by Southern analysis. Thus, this study, taking advantage of the presence of an unusual population of blood atypical B cells, confirms data obtained on lymph nodes where, however, malignant cells may be scarce, indicating that NLPHD is a polyclonal B cell lympho-proliferative disease of mantle zone origin.
authors.affiliation: Laboratory of Immunopathology, University Paris VII, France.
authors.forename: X
authors.initials: X
authors.lastname: Mariette
authors.forename: A
authors.initials: A
authors.lastname: Tsapis
authors.forename: E
authors.initials: E
authors.lastname: Oksenhendler
authors.forename: M T
authors.initials: MT
authors.lastname: Daniel
authors.forename: M F
authors.initials: MF
authors.lastname: D'Agay
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: J C
authors.initials: JC
authors.lastname: Brouet
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D015139:Blotting, Southern; D006689:Hodgkin Disease / Q000097:blood* / Q000235:genetics / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016131:Lymphocyte Subsets; D008218:Lymphocytosis / Q000276:immunology / Q000473:pathology; D008297:Male