[The cellular immunity and cyclonucleotide level in the immunoregulatory cells of patients with bronchial asthma and chronic bronchitis].
The paper presents the analysis of T-cell immunity in asthmatics and bronchitis chronics. Immunodeficiency in one-third of them was characterized by thymic failure. T-cell insufficiency was registered in 50% and 37% of atopic and bacterial asthma patients, respectively, in 40% and 25% of those with chronic obstructive bronchitis and nonobstructive one, respectively. Imbalance of immunoregulatory cells in atopic asthma in 87% of relevant patients and in 37% of chronics with obstructive bronchitis was indicated by enhanced suppressor activity. In patients with bacterial asthma and chronic nonobstructive bronchitis (in 40% and 25%, respectively) helper-cell activity rose. A cAMP concentration proved reduced in helper cells and helper + suppressor subpopulations in bacterial asthma and obstructive bronchitis chronics, respectively. Atopic bronchial asthma was associated with low suppressor subpopulation. Variants of immunocorrection in the above conditions are presented for discussion.
Strigin
V M
VM
Kolesnikov
A P
AP
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000209:etiology / Q000276:immunology*; D001991:Bronchitis / Q000209:etiology / Q000276:immunology*; D002908:Chronic Disease; D000242:Cyclic AMP / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology*
D000242:Cyclic AMP
Kletochnyĭ immunitet i uroven' tsiklonukleotidov v immunoreguliatornykh kletkakh bol'nykh bronkhial'noĭ astmoĭ i khronicheskim bronkhitom.