[Antiphospholipid antibodies: cause of thrombosis or an epiphenomenon?].
Antiphospholipid antibodies (aPL) present in systemic lupus erythematosus and the primary antiphospholipid syndrome are a well-known risk factor for thrombosis. Most of them require the presence of a cofactor, beta 2-glycoprotein I for anticardiolipin antibodies, prothrombin for lupus anticoagulant. These aPL are of the "immune" type. APL are also found in various non-immunological conditions, in which repeated endothelial or membranous damages appear to be frequent, but thromboses are rare. Most of these aPL are cofactor-independent, except those induced by chlorpromazine, and might belong to "natural" antibodies.
Karmochkine
M
M
Service de Médecine interne, CHU Pitié-Salpêtrière, Paris.
Piette
J C
JC
Mazoyer
E
E
Wechsler
B
B
Chérin
P
P
Herson
S
S
Godeau
P
P
Boffa
M C
MC
D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D012307:Risk Factors; D013927:Thrombosis / Q000276:immunology* / Q000503:physiopathology
D017152:Antibodies, Antiphospholipid
Anticorps antiphospholipides: cause des thromboses ou épiphénomène?