title: Peduncular 'rubral' tremor and dopaminergic denervation: a PET study.
abstract: Lesions causing so-called rubral tremors frequently involve the substantia nigra or the nigrostriatal fibers, suggesting dopaminergic denervation as possibly contributory. We examined this hypothesis using PET and [18F]-fluorodopa in six patients with a contralateral tremor following a peduncular lesion. The denervation revealed by PET was even more marked than in severe parkinsonian patients. All patients showed partial to complete improvement with levodopa therapy. PET evaluation of D2-receptors with [76Br]bromolisuride showed no asymmetry of the D2 binding despite the important asymmetry of 18F-fluorodopa uptake. Our results indicate an important involvement of the nigral dopaminergic system in peduncular tremors that appears to be independent of postsynaptic dopamine receptors.
authors.affiliation: Service Hospitalier Frédéric Joliot, Orsay, France.
authors.forename: P
authors.initials: P
authors.lastname: Remy
authors.forename: A
authors.initials: A
authors.lastname: de Recondo
authors.forename: G
authors.initials: G
authors.lastname: Defer
authors.forename: C
authors.initials: C
authors.lastname: Loc'h
authors.forename: P
authors.initials: P
authors.lastname: Amarenco
authors.forename: V
authors.initials: V
authors.lastname: Planté-Bordeneuve
authors.forename: M H
authors.initials: MH
authors.lastname: Dao-Castellana
authors.forename: B
authors.initials: B
authors.lastname: Bendriem
authors.forename: C
authors.initials: C
authors.lastname: Crouzel
authors.forename: M
authors.initials: M
authors.lastname: Clanet
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001930:Brain Injuries / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000000981:diagnostic imaging*; D011954:Receptors, Dopamine / Q000378:metabolism / Q000502:physiology*; D012012:Red Nucleus / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D013378:Substantia Nigra / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D014055:Tomography, Emission-Computed; D014202:Tremor / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*
chemical_list: D011954:Receptors, Dopamine