title: Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones.
abstract: Hsp90 and small Hsps are two abundant types of eukaryotic stress protein whose function has remained largely enigmatic. In the cell, Hsp90 exists in a complex (with other Hsps and prolyl isomerases) possibly implicated in interactions with non-native proteins. Recent biochemical analysis of both Hsp90 and small Hsps has revealed that they may act as ATP-independent molecular chaperones involved in protein folding and unfolding events.
authors.affiliation: Institut für Biophysik und Physikalische Biochemie, Universität Regensburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Jakob
authors.forename: J
authors.initials: J
authors.lastname: Buchner
mesh_terms: D000595:Amino Acid Sequence; D018833:Chaperonins; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data; D017510:Protein Folding; D011506:Proteins / Q000502:physiology*
chemical_list: D006360:Heat-Shock Proteins; D011506:Proteins; D018833:Chaperonins