Molecular analysis of the t(1;19)(q23;p13) translocation observed in adult leukemias.
We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19) by RNA-based polymerase chain reaction. This patient survived for 8 months only from the time of his diagnosis. On the other hand, the other two cases were negative for the E2A/PBX1 fusion and one of them with ALL remains in remission. Our observations suggest that there could be heterogeneity in the molecular events among adult leukemias carrying the t(1;19) and that the E2A/PBX1 fusion formation might also be associated with an adverse treatment outcome in adult leukemias as in childhood leukemias.
Mitani
K
K
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Sasaki
K
K
Ogawa
S
S
Hayashi
Y
Y
Mano
H
H
Yazaki
Y
Y
Hirai
H
H
D000293:Adolescent; D000368:Aged; D001483:Base Sequence; D002678:Chimera; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D014157:Transcription Factors / Q000235:genetics; D014178:Translocation, Genetic
D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors