title: Synthesis of some new 1,6-dihydro-3-substituted-6-spiro-(9'-fluorene)-1,2,4-triazin-5-( 4H)-on es as potential anti HIV and anticancer drugs.
abstract: 1,6-Dihydro-3 (2H)-thioxo-6-spiro-(9'-fluorene)-1,2,4-triazin-5(4H)-one (1) has been used to synthesize several analogous compounds via nucleophilic substitution reactions. Spectroscopic data are given in support of the proposed structures. Some of the new products possessed good anti HIV and anticancer activities.
authors.affiliation: Department of Chemistry, Faculty of Education, Ain Shams University Roxy, Cairo, Egypt.
authors.forename: R M
authors.initials: RM
authors.lastname: Abdel-Rahman
authors.forename: M
authors.initials: M
authors.lastname: Seada
authors.forename: M
authors.initials: M
authors.lastname: Fawzy
authors.forename: I
authors.initials: I
authors.lastname: el Baz
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006678:HIV / Q000187:drug effects*; D006801:Humans; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D013141:Spiro Compounds; D014227:Triazines