Role of the renin-angiotensin system in arterial hypertension secondary to acute unilateral urinary obstruction.
Acute unilateral ureteral obstruction (AUUO) has been associated to a blood pressure increase, presumably secondary to activation of the renin-angiotensin system (RAS), since the obstructed kidney increases renin secretion (Ref. 8). In an attempt to delineate the role of the RAS in this hypertensive model, we acutely obstructed the ureter in two groups of dogs that previous to the obstruction received either placebo (G I, n = 8) or 50 mg of captopril, an angiotensin-converting enzyme inhibitor (G II, n = 9). Animals that received placebo showed a consistent increase in mean arterial pressure (MAP), 128 +/- 4 vs. 144 +/- 4 mm Hg (p < 0.001); those that received captopril did not show such a tendency: 135 +/- 7 vs. 135 +/- 7 mm Hg. In further studies, three groups of animals were included: group III (G III, n = 4), identical to G I except that plasma renin activity (PRA) and aldosterone (ALDO) were measured; Group IV (G IV, n = 5), identical to G II except that they received 50 mg of indomethacin, 60 min before captopril; and group V (G V, n = 6), which was sham operated and measured for PRA and ALDO.(ABSTRACT TRUNCATED AT 250 WORDS)
Hernández-Llamas
G
G
Unidad de Medicina y Cirugía Experimental, Universidad Autónoma de Sinaola, Mexico.
Palafox-Cervantes
G
G
Borboa-Osuna
A L
AL
Urrecha-Manzano
J
J
Cruz
C
C
Pedraza-Chaverrí
J
J
Cuetos-Martínez
C
C
D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D012083:Renin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D014517:Ureteral Obstruction / Q000150:complications* / Q000503:physiopathology
D000450:Aldosterone; D002216:Captopril; D012083:Renin