title: Association between HLA antigens and progression of HIV infection in Greek haemophiliacs.
abstract: The frequencies of HLA antigens in 33 HIV seronegative and in 88 HIV seropositive haemophiliacs, who have been followed for at least 6 years since seroconversion or first HIV positive test, were evaluated in relation to disease susceptibility and disease progression. A high frequency of HLA-A2 and -DR2 antigens and a low frequency of HLA-A9 were found to characterize HIV seropositive patients (p < 0.05). Progressors to symptomatic CDC stage IV had a higher frequency of HLA-A9 (p < 0.01) and DR3. Rapid decline of CD4+ T cells in these patients was associated with HLA-A9, -DR1 and DR3. Our data suggest that HLA antigens may contribute to susceptibility to HIV infection and disease progression in Greek haemophiliacs.
authors.affiliation: Dept. of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Papasteriades
authors.forename: J
authors.initials: J
authors.lastname: Economidou
authors.forename: H
authors.initials: H
authors.lastname: Pappas
authors.forename: K
authors.initials: K
authors.lastname: Psarra
authors.forename: V
authors.initials: V
authors.lastname: Kapsimali
authors.forename: K
authors.initials: K
authors.lastname: Karafoulidou
authors.forename: T
authors.initials: T
authors.lastname: Mandalaki
authors.forename: G
authors.initials: G
authors.lastname: Papaevangelou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006467:Hemophilia A / Q000150:complications / Q000276:immunology*; D006801:Humans; D008875:Middle Aged
chemical_list: D006680:HLA Antigens