title: A genetic map of the mouse with 4,006 simple sequence length polymorphisms.
abstract: We have constructed a genetic map of the mouse genome containing 4,006 simple sequence length polymorphisms (SSLPs). The map provides an average spacing of 0.35 centiMorgans (cM) between markers, corresponding to about 750 kb. Approximately 90% of the genome lies within 1.1 cM of a marker and 99% lies within 2.2 cM. The markers have an average polymorphism rate of 50% in crosses between laboratory strains. The markers are distributed in a relatively uniform fashion across the genome, although some deviations from randomness can be detected. In particular, there is a significant underrepresentation of markers on the X chromosome. This map represents the two-thirds point toward our goal of developing a mouse genetic map containing 6,000 SSLPs.
authors.affiliation: Whitehead Institute/MIT Center for Genome Research, Cambridge, Massachusetts 02142.
authors.forename: W F
authors.initials: WF
authors.lastname: Dietrich
authors.forename: J C
authors.initials: JC
authors.lastname: Miller
authors.forename: R G
authors.initials: RG
authors.lastname: Steen
authors.forename: M
authors.initials: M
authors.lastname: Merchant
authors.forename: D
authors.initials: D
authors.lastname: Damron
authors.forename: R
authors.initials: R
authors.lastname: Nahf
authors.forename: A
authors.initials: A
authors.lastname: Gross
authors.forename: D C
authors.initials: DC
authors.lastname: Joyce
authors.forename: M
authors.initials: M
authors.lastname: Wessel
authors.forename: R D
authors.initials: RD
authors.lastname: Dredge
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005819:Genetic Markers; D016678:Genome; D008297:Male; D051379:Mice / Q000235:genetics*; D011110:Polymorphism, Genetic; D014960:X Chromosome
chemical_list: D005819:Genetic Markers