New heterocyclic derivatives of benzimidazole with germicidal activity--XII--Synthesis of N1-glycosyl-2-furyl benzimidazoles.
Over the last decade, several derivatives of benzimidazole have been synthesized; some of them turned out to have a good antimicrobial activity; however, all of them were not soluble in water. Therefore the N1-heterosides of four derivatives of 2-(2'-furyl) benzimidazole, chosen from those with the highest biological activity have been now synthesized. These compounds were expected to have some new properties, including a good water-solubility and a higher or at least similar biological activity; furthermore, taking into account some previously published data on similar molecules, an antileukemic activity was expected. However, no one of these hypothesis was confirmed experimentally.
Pedini
M
M
Istituto di Biochimica e Chimica Medica, Facoltà di Medicina e Chirurgia, Università degli Studi di Perugia, Italia.
Alunni Bistocchi
G
G
Ricci
A
A
Bastianini
L
L
Lepri
E
E
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D007941:Leukemia P388 / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000890:Anti-Infective Agents; D001562:Benzimidazoles