title: Cerebrospinal fluid oxytocin concentration in schizophrenic patients does not differ from control subjects and is not changed by neuroleptic medication.
abstract: Cerebrospinal fluid (CSF) oxytocin concentrations in 20 neuroleptic-treated schizophrenic patients, 31 neuroleptic-withdrawn schizophrenic patients, and 15 normal control subjects were compared. Neither within-subject comparisons of CSF oxytocin concentration measurements made during neuroleptic treatment and withdrawal (n = 11), nor comparison of the combined neuroleptic-withdrawn and neuroleptic-treated patient group (n = 40) with control subjects (n = 15) differed significantly, suggesting that CSF oxytocin concentration is not altered in schizophrenia.
authors.affiliation: Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, Washington, DC 20032.
authors.forename: D
authors.initials: D
authors.lastname: Glovinsky
authors.forename: K T
authors.initials: KT
authors.lastname: Kalogeras
authors.forename: D G
authors.initials: DG
authors.lastname: Kirch
authors.forename: R
authors.initials: R
authors.lastname: Suddath
authors.forename: R J
authors.initials: RJ
authors.lastname: Wyatt
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010121:Oxytocin / Q000134:cerebrospinal fluid*; D012016:Reference Values; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D013375:Substance Withdrawal Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis
chemical_list: D014150:Antipsychotic Agents; D010121:Oxytocin