[The beta-adrenolytic activity of new arylmethyloxypropanolamine analogs of dioxadilol].
A series of arylmethyloxypropanolamines structurally related to Dioxadilol has been synthesized and tested for their beta adrenolytic activity. Only one compound, the benzofuranic derivative 3c, exhibited a similar activity as Dioxadilol but was less potent than propranolol.
Baziard-Mouysset
G
G
Laboratoire de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse.
Ane-Margail
M
M
Stigliani
J L
JL
Payard
M
M
Verscheure
Y
Y
Tisne-Versailles
J
J
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D008297:Male; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines
Etude de l'activité beta adrénolytique de nouvelles arylméthyloxypropanolamines analogues du Dioxadilol.