Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred.
Genetic linkage studies of a kindred from Sweden segregating for schizophrenia have been performed using a genetic model (autosomal dominant, f = 0.72, q = 0.02, phenocopies = 0.001) as described in Kennedy et al., 1988. Analyses of the restriction fragment length polymorphism (RFLP), allele-specific oligonucleotides (ASO), and short tandem repeat (STR also called microsatellite) data for 180 polymorphisms (individual probe-enzyme, ASO, or STR systems) at 155 loci have been completed using the MLINK and LIPED programs. Linkage to schizophrenia was excluded, under the given model, at 47 loci; indeterminate lod scores occurred at 108 loci. The total exclusion region across 20 chromosomes is estimated at 330 cM; 211 cM excluded by pairwise analyses and 119 cM previously excluded by multipoint analyses (Kennedy et al., 1989: Schizophr Bull 15:383-391; Moises et al. 1991: Genet Epidemiol 2:99-110; Hallmayer et al., 1992: Arch Gen Psychiatry 49:216-219).
Barr
C L
CL
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.
Kennedy
J L
JL
Pakstis
A J
AJ
Wetterberg
L
L
Sjögren
B
B
Bierut
L
L
Wadelius
C
C
Wahlström
J
J
Martinsson
T
T
Giuffra
L
L
D000483:Alleles; D005387:Finland / Q000208:ethnology; D005799:Genes, Dominant; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D015345:Oligonucleotide Probes; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012559:Schizophrenia / Q000235:genetics*; D013548:Sweden
D015345:Oligonucleotide Probes