Serum levels of intercellular adhesion molecule 1 in patients with HIV-related Kaposi's sarcoma.
Infection with the human immunodeficiency virus type 1 (HIV-1) in man is associated with an increase in the incidence of Kaposi's sarcoma (KS). The biological and clinical characteristics of these patients differ from those of subjects with other HIV-associated diseases. Here we report that levels of serum-soluble intercellular adhesion molecule 1 (sICAM 1) are increased in HIV-1-positive patients with KS, but not in patients belonging to other CDC classification groups. KS patients with elevated levels of serum sICAM 1 had a significant lowering of CD4 cell counts during the follow-up period compared with those KS subjects whose sICAM 1 levels were only moderately higher. We suggest that increased sICAM 1 levels may have a pathogenetic role in the development of HIV-associated immunodeficiency in KS patients and may also be considered an important prognostic factor.
De Paoli
P
P
Microbiology-Immunology-Virology Division, Centro di Riferimento Oncologico, Aviano, Italy.
Caffau
C
C
D'Andrea
M
M
Tavio
M
M
Tirelli
U
U
Santini
G
G
D015703:Antigens, CD / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes; D015815:Cell Adhesion Molecules / Q000097:blood*; D015658:HIV Infections / Q000097:blood / Q000150:complications*; D006679:HIV Seropositivity / Q000097:blood / Q000150:complications; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007958:Leukocyte Count; D012514:Sarcoma, Kaposi / Q000097:blood* / Q000209:etiology
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1