title: [A clinico-pharmacological study of an ophthalmic drug form of proxodolol].
abstract: The experiments on rabbits and the clinical studies of patients with primary open-angle glaucoma revealed that 1% and 2% solutions of the new beta-, alpha-adrenoceptor blocking drug proxodolol had a marked antihypertensive effect. Proxodolol reduced intraocular pressure, by decreasing the rate of aqueous humor inflow. The study of the effects of proxodolol versus timolol on intraocular pressure showed that their antihypertensive effects were identical.
authors.forename: V N
authors.initials: VN
authors.lastname: Ermakova
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D004341:Drug Evaluation; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009883:Ophthalmic Solutions; D010069:Oxadiazoles / Q000008:administration & dosage* / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology; D014065:Tonometry, Ocular
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; D010069:Oxadiazoles; C088649:proxodolol; D013999:Timolol
vernacular_title: Kliniko-farmakologicheskoe issledovanie glaznoĭ lekarstvennoĭ formy proksodolola.