Albumin microspheres as a drug delivery system for dexamethasone: pharmaceutical and pharmacokinetic aspects.
Four types of albumin microspheres containing dexamethasone prepared by varying cross-linking time--30, 60, 120 and 180 min--were tested to examine the influence of heat cross-linking degree on the in-vitro drug release. Release rate of dexamethasone associated with the microspheres was slower for samples with a longer time of high temperature denaturation. Encapsulation in heat-stabilized albumin microspheres for 60 min at 100 degrees C significantly retards the in-vivo release of dexamethasone and hence retards absorption from the injection site.
Dilova
V
V
Department of Galenical, Chemical Pharmaceutical Research Institute, Sofia, Bulgaria.
Shishkova
V
V
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D003907:Dexamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D006207:Half-Life; D007273:Injections, Intramuscular; D008863:Microspheres; D011489:Protein Denaturation; D012710:Serum Albumin, Bovine; D012756:Sheep
D003692:Delayed-Action Preparations; D012710:Serum Albumin, Bovine; D003907:Dexamethasone