Dose response in the treatment of breast cancer.
We present evidence that drugs that are effective in causing regression of metastatic breast cancer in a dose-dependent fashion also cause a dose-dependent reduction of cytokines produced by the immune system. This may be an important factor in the occasional induction of a complete remission.
Stewart
T H
TH
Ottawa General Hospital, Ontario, Canada.
Retsky
M W
MW
Tsai
S C
SC
Verma
S
S
D016026:Bone Marrow Transplantation; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000556:secondary / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D016207:Cytokines / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D011278:Pregnanes / Q000627:therapeutic use; D012074:Remission Induction
D016207:Cytokines; D011278:Pregnanes