title: Duodenal ulcer treated with Helicobacter pylori eradication: seven-year follow-up.
abstract: The long-term benefits of Helicobacter pylori-eradication treatment (HET) in H pylori-associated duodenal ulcer are unclear. We followed up patients with duodenal ulcers from a trial of H pylori eradication in 1985-86. 63 of 78 patients (81%) were reviewed clinically and had upper gastrointestinal endoscopy with gastric antral biopsy. Of 35 patients previously rendered H pylori negative, 32 (92%) remained H pylori negative after 7.1 years (mean). All patients initially H pylori positive remained infected, unless HET was given in the interim. Duodenal ulceration was found in 20% (5 out of 25) of patients remaining H pylori-positive, compared with 3% (1 of 38) of H pylori-negative patients (p < 0.05). The reduction of duodenal ulcer relapse obtained from H pylori eradication in H pylori-associated duodenal ulcer extends to at least 7 years after treatment, and is likely to be due to freedom from H pylori infection. However, duodenal ulcer may recur in patients rendered H pylori negative, due to factors other than reinfection with H pylori.
authors.affiliation: Department of Gastroenterology, Royal Perth Hospital, Western Australia.
authors.forename: G M
authors.initials: GM
authors.lastname: Forbes
authors.forename: M E
authors.initials: ME
authors.lastname: Glaser
authors.forename: D J
authors.initials: DJ
authors.lastname: Cullen
authors.forename: J R
authors.initials: JR
authors.lastname: Warren
authors.forename: K J
authors.initials: KJ
authors.lastname: Christiansen
authors.forename: B J
authors.initials: BJ
authors.lastname: Marshall
authors.forename: B J
authors.initials: BJ
authors.lastname: Collins
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005756:Gastritis / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome