Liver plasma membrane-bound enzymes and lipids in golden hamsters infected with Ancylostoma ceylanicum.
Infection of golden hamsters with Ancylostoma ceylanicum caused significant decrease in body weight, liver weight and the protein content of liver plasma membrane. Significant inhibition of liver plasma membrane enzymes activities-5'Nucleotidase, gamma-glutamyl transpeptidase, NADHK3Fe (CN)6 reductase, Na+/K(+)-ATPase, CA(2+)-ATPase and Mg(2+)-ATPase was observed in infected animals compared to corresponding controls. Sialic acid content and phospholipid/cholesterol ratio in liver plasma membrane of the infected group were significantly reduced. The study suggests that changes in both the structural and functional organization of membrane may be a biochemical basis of the hepatotoxic effects.
Srivastava
S C
SC
Industrial Toxicology Research Centre, Lucknow, India.
D015720:5'-Nucleotidase / Q000032:analysis; D000251:Adenosine Triphosphatases / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000724:Ancylostomiasis / Q000201:enzymology* / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D006224:Cricetinae; D008099:Liver / Q000201:enzymology* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008563:Membrane Lipids / Q000032:analysis*; D008647:Mesocricetus; D005723:gamma-Glutamyltransferase / Q000032:analysis
D008563:Membrane Lipids; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D015720:5'-Nucleotidase; D000251:Adenosine Triphosphatases