title: Double-echo multislice proton spectroscopic imaging using Hadamard slice encoding.
abstract: Simultaneous multislice proton spectroscopic imaging (SI) is presented using a pulse sequence with multifrequency selective RF excitation and Hadamard encoding in the slice direction, and conventional Fourier phase encoding in the in-plane directions. Double-echo data acquisition is used to increase the spectral information of the experiment. Tests on a phantom demonstrate the quality of the slice selection. Results of in vivo measurements of the healthy rat brain show that spectra with a high signal-to-noise ratio can be acquired from four slices within 32 min. The measurements were performed at 4.7 T using a field of view of 32 x 32 mm2, a slice thickness of 3 mm, and a voxel size of 12 microliters. The proposed method is a useful alternative to sequential multislice SI and 3D SI. Furthermore, it is possible to combine sequential and simultaneous multislice SI.
authors.affiliation: Universität Bremen, Fachbereich Chemie/Biologie (FB2), Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Dreher
authors.forename: D
authors.initials: D
authors.lastname: Leibfritz
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005583:Fourier Analysis; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D005973:Glutamine / Q000378:metabolism; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008961:Models, Structural; D010725:Phosphocreatine / Q000378:metabolism; D011522:Protons; D051381:Rats; D017208:Rats, Wistar; D014867:Water
chemical_list: D005971:Glutamates; D011522:Protons; D010725:Phosphocreatine; D014867:Water; D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline