title: The radiation chemistry of d(CpGpTpA) in the presence of oxygen.
abstract: This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradiated in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligomers guanine is hydroxylated at the 8-position and an adjacent pyrimidine is degraded to a formamido remnant.
authors.affiliation: Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York 14263.
authors.forename: E E
authors.initials: EE
authors.lastname: Budzinski
authors.forename: J D
authors.initials: JD
authors.lastname: Dawidzik
authors.forename: J C
authors.initials: JC
authors.lastname: Wallace
authors.forename: H G
authors.initials: HG
authors.lastname: Freund
authors.forename: H C
authors.initials: HC
authors.lastname: Box
mesh_terms: D004249:DNA Damage; D009838:Oligodeoxyribonucleotides / Q000528:radiation effects*; D010100:Oxygen / Q000494:pharmacology*
chemical_list: D009838:Oligodeoxyribonucleotides; D010100:Oxygen