title: Effect of nicotine on swimming exercise in rats.
abstract: In this study, endurance time in swimming exercise was evaluated in rats. Subcutaneous (S.C.) injection of nicotine decreased the endurance time in swimming exercise significantly, in a dose-dependent manner compared to the control group. At the dose of 0.125 mg/kg nicotine, the endurance time in swimming exercise remained unchanged, while at the doses of 0.25 and 0.375 mg/kg, it decreased significantly (p < 0.05 and p < 0.01, respectively). This effect of nicotine was antagonized by pretreatment with hexamethonium 5 mg/kg S.C. These results suggest that nicotine may limit the physical performance.
authors.affiliation: Department of Physiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Temocin
authors.forename: A
authors.initials: A
authors.lastname: Erenmemisoglu
authors.forename: C
authors.initials: C
authors.lastname: Suer
authors.forename: H
authors.initials: H
authors.lastname: Beydagi
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010807:Physical Endurance / Q000187:drug effects / Q000502:physiology; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013550:Swimming / Q000502:physiology
chemical_list: D006584:Hexamethonium Compounds; D018738:Hexamethonium; D009538:Nicotine