title: Protection against cisplatin lethality and renal toxicity by chlorpromazine in mice.
abstract: The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine (i.p.) given 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin, while chlorpromazine did not reduce the antitumor activity of cisplatin against sarcoma 180 in ddY mice or El-4 leukemia in C57BL/6J mice.
authors.affiliation: Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: M
authors.initials: M
authors.lastname: Ozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Takayanagi
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D007668:Kidney / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009584:Nitrogen / Q000652:urine; D051437:Renal Insufficiency / Q000139:chemically induced / Q000517:prevention & control*; D012510:Sarcoma 180 / Q000188:drug therapy
chemical_list: D009584:Nitrogen; D002945:Cisplatin; D002746:Chlorpromazine