title: Left ventricular performance and cerebral haemodynamics during xenon anaesthesia. A transoesophageal echocardiography and transcranial Doppler sonography study.
abstract: The effects of xenon anaesthesia on myocardial function and cerebral blood flow velocities were investigated with transoesophageal echocardiography and transcranial Doppler sonography. Seventeen ASA 1 patients undergoing open cholecystectomy (n = 16) or abdominal hysterectomy (n = 1) were studied. Anaesthesia with 65% xenon in oxygen was induced by ventilating the lungs through a circle system with minimal fresh gas flow. The echocardiographically obtained mean (SD) fractional area change in a short axis view of the left ventricle at the level of the papillary muscles was 65 (10)% (n = 14) before xenon. There was no significant change after 5, 10 and 15 min of xenon anaesthesia. Cerebral blood flow velocities were unchanged during the first 5 min of xenon anaesthesia, but were significantly increased in the left and right middle, and the right anterior, cerebral arteries after 15 and 30 min (n = 16) (p < 0.05). In conclusion, xenon anaesthesia had no adverse effect on myocardial function, but probably increased cerebral flood flow.
authors.affiliation: Department of Anaesthesia, University Hospital, Lund, Sweden.
authors.forename: H H
authors.initials: HH
authors.lastname: Luttropp
authors.forename: B
authors.initials: B
authors.lastname: Romner
authors.forename: L
authors.initials: L
authors.lastname: Perhag
authors.forename: J
authors.initials: J
authors.lastname: Eskilsson
authors.forename: S
authors.initials: S
authors.lastname: Fredriksen
authors.forename: O
authors.initials: O
authors.lastname: Werner
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D017548:Echocardiography, Transesophageal; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial; D016277:Ventricular Function, Left / Q000187:drug effects*; D014978:Xenon / Q000494:pharmacology*
chemical_list: D014978:Xenon