Cadmium as hypertensive agent. Effect on ion excretion in rats.
1. Sodium, K and Cl excretion and changes in blood volume were studied after parenteral injection of Cd2+ (1 mumol/100 g body weight) in intact and adrenalectomized rats. 2. The final systolic arterial pressure and mean arterial pressure of adrenalectomized rats increase significantly after Cd2+ administration compared with values from control group and initial systolic arterial pressure of each group. 3. Cadmium administration induced a significant inhibition of Na+ excretion in urine and a decrease in blood volume in ADX rats compared with values from control or sham operated rats. 4. The possibility that hypertension induced by Cd may be explained by inhibition of Na excretion and changes in blood volume is discussed.
Peña
A
A
Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Santiago.
Iturri
S J
SJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002104:Cadmium / Q000494:pharmacology* / Q000633:toxicity; D002712:Chlorides / Q000652:urine; D005260:Female; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology / Q000652:urine; D011188:Potassium / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley
D002712:Chlorides; D002104:Cadmium; D011188:Potassium