title: Role of HTLV-I in development of non-Hodgkin lymphoma in Jamaica and Trinidad and Tobago. The HTLV Lymphoma Study Group.
abstract: Human T-cell lymphotropic virus type I (HTLV-I) has been implicated in the aetiology of adult T-cell leukaemia/lymphoma in Japan and elsewhere, particularly the Caribbean. We have carried out parallel case-control studies in Jamaica and in Trinidad and Tobago to quantify the role of HTLV-I in the development of non-Hodgkin lymphoma (NHL). 135 cases of NHL were enrolled in Jamaica and 104 in Trinidad and Tobago. Controls were selected from patients treated in the same wards or clinics at the same time as the cases. Overall, patients with NHL were 10 times more likely than were controls to be seropositive for HTLV-I (Jamaica odds ratio 10.3 [95% CI 6.0-18.0], Trinidad and Tobago 14.4 [7.6-27.2]). In both countries the association between NHL and HTLV-I was greatest for T-cell lymphomas (18.3 [9.5-35.6] and 63.3 [25-167]). Among T-cell lymphomas especially, there was no significant difference between men and women in the association between NHL and HTLV-I, but there was a significant inverse relation between age and likelihood of HTLV-I seropositivity. B-cell lymphomas were predominant in the older age groups and were not associated with HTLV-I seropositivity. These findings are consistent with the hypothesis that early life exposure to HTLV-I is important for risk of subsequent ATL. Prevention of vertical transmission of HTLV-I could reduce by 70-80% cases of NHL in people under 60 years in this region.
authors.affiliation: Epidemiology and Biostatistics Program, National Cancer Institute, Rockville, Maryland 20852.
authors.forename: A
authors.initials: A
authors.lastname: Manns
authors.forename: F R
authors.initials: FR
authors.lastname: Cleghorn
authors.forename: R T
authors.initials: RT
authors.lastname: Falk
authors.forename: B
authors.initials: B
authors.lastname: Hanchard
authors.forename: E S
authors.initials: ES
authors.lastname: Jaffe
authors.forename: C
authors.initials: C
authors.lastname: Bartholomew
authors.forename: P
authors.initials: P
authors.lastname: Hartge
authors.forename: J
authors.initials: J
authors.lastname: Benichou
authors.forename: W A
authors.initials: WA
authors.lastname: Blattner
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D006801:Humans; D007563:Jamaica; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014300:Trinidad and Tobago
chemical_list: D015481:HTLV-I Antibodies