Sudden hearing loss associated with interferon.
With the increasing long-term use of interferon, several new adverse effects have been recognised. We have prospectively assessed auditory function in 49 patients receiving interferon, after we saw a case of sudden sensorineural hearing loss during interferon therapy. Auditory disability (tinnitus, hearing loss, or both) occurred in 22 patients (45%) during treatment with audiometry-documented sensorineural hearing loss in 18 (37%). The auditory disability often developed in the late stage of treatment and resolved in all patients within 7-14 days after discontinuation of interferon.
Kanda
Y
Y
Department of Otolaryngology, Nagasaki University School of Medicine, Japan.
Shigeno
K
K
Kinoshita
N
N
Nakao
K
K
Yano
M
M
Matsuo
H
H
D000328:Adult; D000368:Aged; D001299:Audiometry; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006509:Hepatitis B / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D016899:Interferon-beta / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014012:Tinnitus / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*
D016898:Interferon-alpha; D016899:Interferon-beta