title: Neuroleptic treatment of patients with schizophrenia. Mechanisms of action and clinical significance.
abstract: Neuroleptic drugs have been used in the treatment of schizophrenic patients for 40 years. In the 1960s it was proposed that the mechanism of action was a blockade of dopamine receptors; in vivo studies give strong evidence that a blockade of D2 dopamine receptors mediate the antipsychotic effect of classic neuroleptics. However, the antipsychotic effect of neuroleptics is synergistic with family treatment and social-skills training.
authors.affiliation: Department of Psychiatry, Uppsala University, Sweden.
authors.forename: F A
authors.initials: FA
authors.lastname: Wiesel
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D003131:Combined Modality Therapy; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine