Susceptibility of BL6 nude (congenitally athymic) mice to Japanese encephalitis virus by the peripheral route.
Studies on the susceptibility of adult BL6 nude (congenitally athymic, nu/nu) mice, their euthymic littermates (+/nu) and Swiss mice to Japanese encephalitis (JE) virus inoculated subcutaneously were carried out. The mice were observed over a period of 60 days p.i. for sickness and/or death, which was noticed only in nu/nu mice. However, the onset and the duration of sickness varied and no definite pattern was observed. Thirty four of 53 nu/nu, 28 of 42 +/nu and 30 of 52 Swiss mice bled during the first 5 days p.i. exhibited viraemia. Interestingly, only nu/nu mice had secondary viraemia during the period of sickness. The cause of sickness and death in nu/nu mice was confirmed by recovering the virus from the blood, the brain and other organs. Antibodies were detected in the sera of +/nu and Swiss mice from the 10th day p.i. onwards but not in nu/nu mice. These findings indicate the important role of functional T cells both in induction of active immunity and protection against JE virus infection in mice.
Lad
V J
VJ
National Institute of Virology, Pune, India.
Gupta
A K
AK
Goverdhan
M K
MK
Ayachit
V L
VL
Rodrigues
J J
JJ
Hungund
L V
LV
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000276:immunology / Q000662:veterinary; D004664:Encephalitis Virus, Japanese / Q000472:pathogenicity*; D004672:Encephalitis, Japanese / Q000276:immunology* / Q000473:pathology; D007279:Injections, Subcutaneous; D007958:Leukocyte Count / Q000662:veterinary; D051379:Mice / Q000276:immunology / Q000382:microbiology; D008819:Mice, Nude / Q000276:immunology / Q000382:microbiology*; D013045:Species Specificity
D000914:Antibodies, Viral