The effect of somatostatin on small intestinal transport in intractable diarrhoea of infancy.
It has been reported that somatostatin may be an effective antisecretory agent in a range of conditions causing severe secretory diarrhoea. In many children, intractable diarrhoeal illnesses result in significant morbidity and mortality. In a group of seven children with secretory diarrhoea, the effect of i.v. infusion of somatostatin (3.5 micrograms/kg stratum plus 3.5 micrograms/kg/h) on the net mucosal flux of salt and water was assessed using an in vivo steady-state perfusion technique. In one of the seven children who had evidence of deranged mucosal secretion and preserved villus function, somatostatin infusion resulted in a moderate reduction in secretion. In the remaining six, it had little or no beneficial effect. Somatostatin did not alter the rate of glucose absorption.
Bisset
W M
WM
Medical Unit, Institute of Child Health, London, England.
Jenkins
H
H
Booth
I
I
Smith
V
V
Milla
P J
PJ
D002648:Child; D002675:Child, Preschool; D002713:Chlorine / Q000378:metabolism; D003968:Diarrhea, Infantile / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005632:Fructose / Q000097:blood; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D043322:Lactase; D008297:Male; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013393:Sucrase / Q000032:analysis; D014198:Trehalase / Q000032:analysis; D014867:Water / Q000378:metabolism; D001616:beta-Galactosidase / Q000032:analysis
D014867:Water; D005632:Fructose; D002713:Chlorine; D013004:Somatostatin; D043322:Lactase; D001616:beta-Galactosidase; D014198:Trehalase; D013393:Sucrase; D005947:Glucose