title: Is the muscle metaboreflex important in control of blood flow to ischemic active skeletal muscle in dogs?
abstract: Ischemia of active skeletal muscle induces a reflex increase in sympathetic activity, heart rate, cardiac output, and arterial pressure, termed the muscle metaboreflex. Whether this pressor response contributes importantly in the regulation of blood flow to the ischemic active skeletal muscle is not well understood. If the pressor response is achieved without substantial vasoconstriction in the ischemic muscle, this increase in arterial pressure would act to improve muscle blood flow. Dogs performed treadmill exercise at mild (3.2 km/h, 0% grade) and moderate (6.4 km/h, 10% grade) workloads. During each workload, resistance to blood flow in the hindlimbs (Rh) was increased via graded partial inflation of a vascular occluder implanted on the terminal aorta. The closed-loop gain of the muscle metaboreflex (Gcl) was calculated, based on the steady-state changes in terminal aortic blood flow (TAQ). If no pressor response occurred, then TAQ should decrease in proportion to the increase in total Rh (the sum of resistance due to partial vascular occlusion and hindlimb vascular resistance); i.e., no reflex restoration of hindlimb blood flow would occur. However, with a reflex increase in systemic arterial pressure, TAQ could rise above the level predicted on the basis of the increase in Rh. We observed that with the initial increase in Rh during mild exercise, Gcl was not significantly different from zero (P > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201.
authors.forename: D S
authors.initials: DS
authors.lastname: O'Leary
authors.forename: D D
authors.initials: DD
authors.lastname: Sheriff
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D004285:Dogs; D005246:Feedback / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006614:Hindlimb; D007511:Ischemia / Q000097:blood / Q000503:physiopathology*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000503:physiopathology*; D005082:Physical Exertion / Q000502:physiology; D012018:Reflex / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D007773:Lactates; D019344:Lactic Acid