Effect of L-thyroxine and carbimazole on blood levels of biogenic amines in rat.
Circulating levels of 5-hydroxytryptamine (5HT), histamine, monoamine oxidase (MAO), histaminase, tri-iodothyronine (T3) and thyroxine (T4) were studied in L-thyroxine and carbimazole treated rats. Increased concentrations of 5-HT, histamine, glutamate, T3 and T4 were recorded in L-thyroxine-treated rats while plasma gamma-aminobutyric acid (GABA), MAO and histaminase levels were significantly decreased. Considerable reduction in 5-HT, glutamate, T3 and T4 with trend towards the rise in plasma levels of MAO and histaminase was noticed in carbimazole treated group. There was a significant correlation between these amines and thyroid hormone values. The findings suggest that alterations in the metabolism of thyroid hormones may have a link with the altered metabolism of biogenic amines.
Upadhyaya
L
L
Department of Medicine, Banaras Hindu University, Varanasi, India.
Agrawal
J K
JK
Dubey
G P
GP
D006631:Amine Oxidase (Copper-Containing) / Q000097:blood; D000818:Animals; D001679:Biogenic Amines / Q000097:blood*; D002231:Carbimazole / Q000494:pharmacology*; D005971:Glutamates / Q000097:blood; D018698:Glutamic Acid; D006632:Histamine / Q000097:blood; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood; D051381:Rats; D012044:Regression Analysis; D012701:Serotonin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood
D001679:Biogenic Amines; D005971:Glutamates; D014284:Triiodothyronine; D012701:Serotonin; D018698:Glutamic Acid; D006632:Histamine; D002231:Carbimazole; D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase; D013974:Thyroxine