Anti-IL-10 treatment does not block either the induction or the maintenance of orally induced tolerance to OVA.
Herein, the role of IL-10 in the induction and maintenance of oral tolerance was evaluated. The results show that: (1) mice treated with MoAb anti-IL-10 are permissive to the induction of oral tolerance to OVA; (2) anti-IL-10 treatment did not reverse the in vitro blocking of T cell proliferative response found in orally-tolerized mice; and (3) orally-induced tolerance could not be broken by anti-IL-10 treatment. Taken together, these results suggest that IL-10 is not a fundamental cytokine for the establishment and maintenance of oral tolerance.
Aroeira
L S
LS
Department of Biochemistry and Immunology, Federal University of Minas Gerais, Brazil.
Cardillo
F
F
De Albuquerque
D A
DA
Vaz
N M
NM
Mengel
J
J
D000284:Administration, Oral; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay; D007108:Immune Tolerance; D007274:Injections, Intraperitoneal; D016753:Interleukin-10 / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008811:Mice, Inbred DBA; D009061:Mouth Mucosa / Q000276:immunology*; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D016753:Interleukin-10; D010047:Ovalbumin