Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative.
Jimonet
P
P
Rhône-Poulenc Rorer S.A., Central Research, Centre de Recherche de Vitry-Alfortville, Vitry sur Seine, France.
Barreau
M
M
Blanchard
J C
JC
Boireau
A
A
Doble
A
A
Laduron
P
P
Lavayre
J
J
Malgouris
C
C
Piot
O
O
Pratt
J
J
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D002545:Brain Ischemia / Q000517:prevention & control; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D005849:Gerbillinae; D002534:Hypoxia, Brain / Q000517:prevention & control; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009420:Nervous System / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000517:prevention & control; D026941:Sodium Channel Blockers; D015222:Sodium Channels / Q000378:metabolism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*
D000927:Anticonvulsants; C089331:RP 66055; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D013844:Thiazoles; D004298:Dopamine