title: [Rapidly progressive kidney failure associated with neutrophil anticytoplasmic autoantibodies. Anatomo-clinical case].
abstract: We report a 63 year old woman with a rapidly progressive renal failure and fever of unknown origin. Laboratory tests showed anemia, increased ESR and a urine analysis compatible with a glomerular disease. Antineutrophil cytoplasmic autoantibodies were positive with a perinuclear pattern. Kidney biopsy showed an autoimmune crescenteric glomerulonephritis. The patient had a bad evolution, dying after a massive hemoptysis. The necropsy showed a disseminated arteritis without compromise of bronchial vessels. The oligosymptomatic presentation of this patient, bearing in mind the anatomo-pathological findings, is noteworthy and emphasizes the usefulness of serological markers as antineutrophil cytoplasmic autoantibodies in the differential diagnosis.
authors.affiliation: Servicio de Medicina, Facultad de Medicina, Universidad de Chile.
authors.forename: E
authors.initials: E
authors.lastname: Wainstein
authors.forename: A
authors.initials: A
authors.lastname: Puelma
authors.forename: A M
authors.initials: AM
authors.lastname: Carrasco
authors.forename: L
authors.initials: L
authors.lastname: Guzmán
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology; D001323:Autoantibodies / Q000032:analysis*; D003593:Cytoplasm / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010488:Polyarteritis Nodosa / Q000473:pathology; D014657:Vasculitis / Q000150:complications
chemical_list: D001323:Autoantibodies
vernacular_title: Insuficiencia renal rápidamente progresiva asociada a anticuerpos anticitoplasmáticos de neutrófilos. Caso anátomo clínico.