title: Effects of acute exercise on insulin and non-insulin-dependent glucose uptake in normal and moderately obese women.
abstract: OBJECTIVE
  To investigate the effectiveness of exercise on the regulation of insulin sensitivity.
  
  
  METHODS
  Eleven premenopausal women, with body fat mass from the normal range to moderate obesity, were examined with glucose clamp at 10 mmol/L glucose concentration to determine insulin-dependent and non-insulin-dependent (after somatostatin inhibition of endogenous insulin production) glucose uptake (= IDGU and NIDGU respectively) before and 24 hrs after a glycogen-decreasing exercise.
  
  
  RESULTS
  IDGU, but not NIDGU, increased after exercise. The degree of increase of IDGU after exercise showed negative correlations with body mass index (borderline, significance), the waist to hip circumference ratio, fasting free testosterone and free fatty acid concentrations, as well as diastolic blood pressure (borderline significance), and a positive relationship to sex hormone binding globulin concentration and IDGU before exercise.
  
  
  CONCLUSIONS
  It is concluded that only IDGU contributes to the augmentation of insulin sensitivity after a glycogen-decreasing exercise in women. Additionally, the increase of IDGU is less in abdominal obesity, and negatively dependent on free fatty acid concentrations, hyperandrogenism and hyperinsulinaemia, all putative pathogenetic factors for insulin resistance.
authors.affiliation: Department of Medicine, Sahlgren's Hospital, University of Göteborg, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Mårin
authors.forename: M
authors.initials: M
authors.lastname: Krotkiewski
authors.forename: G
authors.initials: G
authors.lastname: Holm
authors.forename: C
authors.initials: C
authors.lastname: Gustafsson
authors.forename: P
authors.initials: P
authors.lastname: Björntorp
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D017697:Premenopause; D013004:Somatostatin / Q000097:blood
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013004:Somatostatin