title: [Clinico-immunologic effect of tactivin in chronic myeloid leukemia].
abstract: Immunological reactivity and factors of nonspecific body defense were studied in 35 patients with advanced chronic myeloid leukemia (CML). Prior to cytostatic therapy, CML patients have secondary combined immunodeficiency manifesting by inhibition of T-system immunity and phagocytic neutrophil activity. Repeated courses of myelosan chemotherapy aggravate the above immune defects. The adjuvant immunomodulator tactivin corrects cellular immunity and reduces the occurrence of infectious complications 1.77-fold.
authors.forename: K M
authors.initials: KM
authors.lastname: Abdulkadyrov
authors.forename: S A
authors.initials: SA
authors.lastname: Guseva
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D013949:Thymus Extracts / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
vernacular_title: Kliniko-immunologicheskiĭ éffekt taktivina pri khronicheskom mieloleĭkoze.