title: Persistence of sodium monofluoroacetate in livestock animals and risk to humans.
abstract: 1. Sodium monofluoroacetate (1080), a vertebrate pesticide widely used in New Zealand, was administered orally to sheep and goats at a dose level of 0.1 mg kg-1 body weight to assess risk to humans of secondary poisoning from meat. Blood, muscle, liver, and kidney were analysed for 1080 residues. 2. The plasma elimination half-life was 10.8 h in sheep and 5.4 h in goats. Concentrations of 1080 in muscle (0.042 microgram g-1), kidney (0.057 microgram g-1), and liver (0.021 microgram g-1) were substantially lower than those in plasma (0.098 microgram ml-1) at 2.5 h after dosing. 3. Only traces of 1080 (< 0.002 to 0.008 microgram g-1) were found in sheep tissues after 96 hours. 4. Livestock are normally excluded from areas where 1080 is being used for pest control, reducing the risk of secondary poisoning. Even with accidental exposure to a sublethal dose 1080 would not persist in tissues for more than a few days because it is cleared rapidly from the body. Therefore the occurrence of 1080 in meat intended for human consumption is highly unlikely.
authors.affiliation: Manaaki Whenua-Landcare Research New Zealand Ltd, Christchurch, New Zealand.
authors.forename: C T
authors.initials: CT
authors.lastname: Eason
authors.forename: R
authors.initials: R
authors.lastname: Gooneratne
authors.forename: H
authors.initials: H
authors.lastname: Fitzgerald
authors.forename: G
authors.initials: G
authors.lastname: Wright
authors.forename: C
authors.initials: C
authors.lastname: Frampton
mesh_terms: D000818:Animals; D005463:Fluoroacetates / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning; D005517:Foodborne Diseases; D006041:Goats; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010573:Pesticide Residues / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning; D012378:Rodenticides / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning; D012756:Sheep
chemical_list: D005463:Fluoroacetates; D010573:Pesticide Residues; D012378:Rodenticides; C014815:fluoroacetic acid