title: Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix.
abstract: The role of specific human papillomaviruses (HPVs) in the aetiology of cancer of the cervix is firmly established. Progression of an HPV-infected cell clone to invasive growth involves consecutive modifications of a set of host cell genes. Some of these modifications suppress viral oncogene functions post-transcriptionally, and others suppress transcription via a signalling pathway stimulated by activated macrophages and possibly by additional cells. I describe a scheme that tries to unify available data by postulating the existence of two intracellular signalling pathways in the control of latent HPV infections.
authors.affiliation: Deutsches Krebsforschungszentrum, Heidelberg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: zur Hausen
mesh_terms: D000818:Animals; D005260:Female; D005814:Genes, Viral / Q000235:genetics; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000821:virology*; D015398:Signal Transduction / Q000235:genetics; D014412:Tumor Virus Infections; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000821:virology*