title: Genomic scan for genes predisposing to schizophrenia.
abstract: We initiated a genome-wide search for genes predisposing to schizophrenia by ascertaining 9 families, each containing three to five cases of schizophrenia. The 9 pedigrees were initially genotyped with 329 polymorphic DNA loci distributed throughout the genome. Assuming either autosomal dominant or recessive inheritance, 254 DNA loci yielded lod scores less than -2.0 at theta = 0.0, 101 DNA markers gave lod scores less than -2.0 at theta = 0.05, while 5 DNA loci produced maximum lod scores greater than 1: D4S35, D14S17, D15S1, D22S84, and D22S55. Of the DNA markers yielding lod scores greater than 1, D4S35 and D22S55 also were suggestive of linkage when the Affected-Pedigree-Member method was used. The families were then genotyped with four highly polymorphic simple sequence repeat markers; possible linkage diminished with DNA markers mapping nearby D4S35, while suggestive evidence of linkage remained with loci in the region of D22S55. Although follow-up investigation of these chromosomal regions may be warranted, our linkage results should be viewed as preliminary observations, as 35 unaffected persons are not past the age of risk.
authors.affiliation: Department of Psychiatry, University of Utah Medical Center, Salt Lake City 84132.
authors.forename: H
authors.initials: H
authors.lastname: Coon
authors.forename: S
authors.initials: S
authors.lastname: Jensen
authors.forename: J
authors.initials: J
authors.lastname: Holik
authors.forename: M
authors.initials: M
authors.lastname: Hoff
authors.forename: M
authors.initials: M
authors.lastname: Myles-Worsley
authors.forename: F
authors.initials: F
authors.lastname: Reimherr
authors.forename: P
authors.initials: P
authors.lastname: Wender
authors.forename: M
authors.initials: M
authors.lastname: Waldo
authors.forename: R
authors.initials: R
authors.lastname: Freedman
authors.forename: M
authors.initials: M
authors.lastname: Leppert
mesh_terms: D000293:Adolescent; D000328:Adult; D002892:Chromosomes, Human, Pair 22; D002894:Chromosomes, Human, Pair 4; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D005819:Genetic Markers