title: A novel cancer predisposition syndrome in the Eker rat model.
abstract: Hereditary renal carcinomas (RCs) develop in virtually all Eker rats by the age of one year. Investigation of extrarenal primary tumors occurring in Eker rats late in life (at 2 years) additionally revealed pituitary adenomas (17/31 = 54.8% (carrier) vs 7/32 = 21.9% (non-carrier siblings of affected animals), P < 0.01), sarcomas of the spleen (21/31 = 67.7% vs. 0/32 = 0%, P < 0.001) and sarcomas (of probable stromal origin) of the uterus (8/17 = 47.1% vs. 0/15 = 0%, P < 0.01). Thus, the Eker rat might provide a novel animal model of cancer predisposition syndromes.
authors.affiliation: Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Hino
authors.forename: H
authors.initials: H
authors.lastname: Mitani
authors.forename: H
authors.initials: H
authors.lastname: Katsuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Kubo
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D002874:Chromosome Mapping; D005260:Female; D016147:Genes, Tumor Suppressor; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D010911:Pituitary Neoplasms / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D051381:Rats; D011922:Rats, Mutant Strains; D013577:Syndrome