Arylsulphatase A (ASA) activity in parkinsonism and symptomatic essential tremor.
Arylsulphatase A (ASA) activity was evaluated in 47 patients with a diagnosis of parkinsonism or essential tremor. Mean ASA activity was significantly reduced compared with both a healthy control group of 71 individuals (p < 0.01) and with a group of 44 neurological patients without movement disorders (p < 0.02). Using definite clinical criteria the patients were classified as typical or atypical with respect to Parkinson's disease (PD) or essential tremor (ET). A normal ASA level was found in all the cases showing typical clinical features (PD and ET), while ASA activity was significantly lowered (p < 0.01) in 55.6% of the atypical cases (Parkinsonian syndrome or symptomatic ET). Our data support the hypothesis of a non-casual association between low ASA level and the clinical features of parkinsonism or symptomatic ET.
Martinelli
P
P
Institute of Neurology, University of Bologna, Italy.
Ippoliti
M
M
Montanari
M
M
Martinelli
A
A
Mochi
M
M
Giuliani
S
S
Sangiorgi
S
S
D000368:Aged; D002553:Cerebroside-Sulfatase / Q000378:metabolism*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000201:enzymology*
D002553:Cerebroside-Sulfatase