The number of noradrenergic and adrenergic neurons in the brain stem does not change with age in male Sprague-Dawley rats.
We examined whether or not the number of noradrenergic and adrenergic neurons changes with age, using peroxidase antiperoxidase (PAP) immunohistochemistry with specific antisera against tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT). TH- and PNMT-immunoreactive neurons were counted in every noradrenergic and adrenergic neuron group of young (3-month-old) and old (24-month-old) rats. The differences in the counted number of TH- and PNMT-immunoreactive neurons did not reach statistical significance between the young and old rats.
Monji
A
A
Department of Neuropsychiatry, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Morimoto
N
N
Okuyama
I
I
Umeno
K
K
Nagatsu
I
I
Ibata
Y
Y
Tashiro
N
N
D000375:Aging / Q000473:pathology*; D000818:Animals; D001933:Brain Stem / Q000166:cytology*; D002452:Cell Count; D004837:Epinephrine / Q000502:physiology*; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000166:cytology*; D009638:Norepinephrine / Q000502:physiology*; D010625:Phenylethanolamine N-Methyltransferase / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D014446:Tyrosine 3-Monooxygenase; D010625:Phenylethanolamine N-Methyltransferase; D009638:Norepinephrine; D004837:Epinephrine