Carbohydrate antigens and liver metastasis in colorectal cancer.
A comparative immunohistochemical study was performed to analyse the expression of cancer-associated carbohydrate antigens by primary and metastatic lesions of colon cancer. We used monoclonal antibodies which reacted with Lea, Lex and Tn as well as their sialylated derivatives. Twenty-one primary lesions in patients without metastasis and 26 primary and metastatic lesions in patients with liver metastasis were studied. Sialyl Lea was expressed by 57% of the primary lesions of patients without metastasis, 65% of the primary lesions of patients with metastasis and 73% of their liver metastases. Sialyl Lex was expressed by 60% of the primary lesions of patients with and without metastasis as well as by approximately 80% of the liver metastases. Sialyl Lea and sialyl Lex showed strong expressions in the liver metastases, significantly greater than in the primary lesions. The findings indicate the increased expressions of sialyl Lea and sialyl Lex to be correlated with liver metastasis of colorectal cancer.
Hasegawa
H
H
Department of Surgery, School of Medicine, Keio University, Tokyo.
Watanabe
M
M
Arisawa
Y
Y
Teramoto
T
T
Kodaira
S
S
Kitajima
M
M
D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D018395:CA-19-9 Antigen; D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D005732:Gangliosides / Q000032:analysis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000032:analysis* / Q000235:genetics; D016256:Lewis X Antigen / Q000032:analysis / Q000235:genetics; D008113:Liver Neoplasms / Q000276:immunology* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000276:immunology* / Q000473:pathology
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D005732:Gangliosides; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; C069719:sialosyl dimeric Le(x) antigen; C055491:sialosyl-Tn antigen; C064564:sialyl Le(a) ganglioside