title: The inhibitory effect of sulfated schizophyllans and related oligosaccharides on coagulation and fibrinolysis.
abstract: Sulfated schizophyllans and sulfated oligosaccharides were prepared and their inhibitory effects on coagulation and fibrinolysis were examined. Some sulfated schizophyllans, which had a sulfur content of more than 10%, prolonged prothrombin time (PT) and thrombin time (TT). Interestingly, some sulfated schizophyllans and related oligosaccharides were able to inhibit plasmin toward fibrinolysis and amidolysis.
authors.affiliation: Research Laboratory, Taito Co., Ltd., Kobe, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hirata
authors.forename: Y
authors.initials: Y
authors.lastname: Nagamatsu
authors.forename: W
authors.initials: W
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Tabata
authors.forename: J
authors.initials: J
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002240:Carbohydrate Sequence; D002417:Cattle; D010450:Endopeptidases / Q000378:metabolism; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009844:Oligosaccharides / Q000494:pharmacology*; D011517:Prothrombin Time; D012566:Sizofiran / Q000494:pharmacology*; D013918:Thrombin Time
chemical_list: D009844:Oligosaccharides; D012566:Sizofiran; D010450:Endopeptidases; D005341:Fibrinolysin