Amino acids and peptides. XXXIX. Synthesis of iNoc-Gln-Val-Val-Ala-Ala-pNA and its action on thiol proteinases.
Based on the results of X-ray analysis of the complex between Suc-Gln-Val-Val-Ala-Ala-pNA, a fairly potent thiol proteinase inhibitor, and papain, iNoc-Gln-Val-Val-Ala-Ala-pNA was designed and prepared and its inhibitory activity against thiol proteinases was examined. iNoc-Gln-Val-Val-Ala-Ala-pNA inhibited cathepsin L fairly specifically, although its potency is not high.
Okada
Y
Y
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Tsuda
Y
Y
Mu
Y
Y
Hirano
K
K
Okamoto
H
H
Okamoto
Y
Y
Kakegawa
H
H
Matsumoto
H
H
Sato
T
T
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D002403:Cathepsins / Q000037:antagonists & inhibitors; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D016415:Sequence Alignment
D000596:Amino Acids; D015853:Cysteine Proteinase Inhibitors; D009842:Oligopeptides; C092688:isonicotinyloxycarbonyl-glutaminyl-valyl-valyl-alanyl-alanine-4-nitroanilide; D002403:Cathepsins