Prenatal ontogeny of D2 dopamine receptor and dopamine transporter gene expression in the rat mesencephalon.
This work demonstrates the early prenatal expression (by gestational day 14) of dopamine D2 receptor and dopamine transporter mRNAs by immature dopaminergic cells of the rat mesencephalon using in situ hybridization. Our results indicate that mRNAs are detectable 3 days before the appearance of functional D2 presynaptic receptors and detectable dopamine release at striatal terminals.
Tison
F
F
URA-CNRS 1200, Laboratoire d'Histologie et Embryologie (UFR II), Université de Bordeaux II, France.
Normand
E
E
Bloch
B
B
D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D015870:Gene Expression / Q000502:physiology*; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008636:Mesencephalon / Q000196:embryology* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D009434:Neural Pathways / Q000378:metabolism; D011247:Pregnancy; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D017448:Receptors, Dopamine D2; D014446:Tyrosine 3-Monooxygenase