A case of intractable diarrhea firmly suspected to have autoimmune enteropathy.
Protracted diarrhea with insulin dependent diabetes mellitus (DM) and hypothyroidism in a 9 month old Japanese girl who was firmly suspected to have autoimmune enteropathy (AIE) is reported. Her severe secretory diarrhea failed to respond to intensive antidiarrheic treatment and was gradually improved with steroid therapy. The circulating autoantibodies to enterocytes in her serum were detected by indirect immunofluorescence technique and the impaired suppressor T (Ts) cell function was proved by plaque forming assay using bead-separated CD4 or CD8 T cells together with CD19 B cells. The anti-enterocyte antibodies were exclusively of immunoglobulin M (IgM) class and were detected with the progress of the protracted diarrhea. Maximum antibody titer was obtained at the onset of DM and the disappearance of autoantibodies was associated with the resolution of the clinical symptoms and signs. The helper functions of adult CD4 T cells to induce Ig-secreting cells from adult and the patient were strikingly suppressed by adult CD8 T cells. However, the CD8 T cells from the patient lost the ability to inhibit the induction of these Ig-secreting cells when stimulated with adult CD4 T cells. Moreover, the patient's CD8 T cells stimulated rather than suppressed the induction of Ig-secreting cells from the patient when stimulated with the patient's CD4 T cells. These results suggest that the impaired Ts cell function in this patient might play some immunological role in the pathogenesis of AIE.
Yamamoto
H
H
Department of Pediatrics, Maternal and Child Center, Tsu National Hospital, Mie, Japan.
Sugiyama
K
K
Nomura
T
T
Taki
M
M
Okazaki
T
T
D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003967:Diarrhea / Q000150:complications*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications; D007410:Intestinal Diseases / Q000150:complications* / Q000276:immunology; D013577:Syndrome; D050378:T-Lymphocytes, Regulatory / Q000502:physiology
D001323:Autoantibodies