Novel cleavage of the 1,2,4-oxadiazole ring in rat metabolism of SM-6586, a dihydropyridine calcium antagonist.
Yabuki
M
M
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, Osaka, Japan.
Shono
F
F
Nakatsuka
I
I
Yoshitake
A
A
D000284:Administration, Oral; D000818:Animals; D002121:Calcium Channel Blockers / Q000378:metabolism*; D002845:Chromatography / Q000379:methods; D004095:Dihydropyridines / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D010069:Oxadiazoles / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D010069:Oxadiazoles; C075861:SM 6586