title: [Human testicular determining factor: from the gene to protein].
abstract: Since its cloning in 1990, the human SRY gene has been formally identified with the testis determining factor. The SRY gene encodes a 204 amino acid protein of the High Mobility Group family. Its ability to bind DNA, to bend DNA or to be translocated into the nuclear compartment of the cell have now been established. However, neither its mode of action nor the description of target genes have been described so far, and are the topics of many studies.
authors.affiliation: Centre de Recherche de Biochimie Macromoléculaire, UPR 9008 CNRS, U 249 INSERM, Montpellier.
authors.forename: F
authors.initials: F
authors.lastname: Poulat
authors.forename: C
authors.initials: C
authors.lastname: Gozé
authors.forename: B
authors.initials: B
authors.lastname: Boizet
authors.forename: P
authors.initials: P
authors.lastname: Berta
mesh_terms: D000595:Amino Acid Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D005801:Genes, Homeobox; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008297:Male; D008969:Molecular Sequence Data; D014157:Transcription Factors; D014998:Y Chromosome / Q000737:chemistry
chemical_list: D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human
vernacular_title: Le facteur de détermination testiculaire humain: du gène à la protéine.