[Arterial hypertension in Cushing's disease: the 24-hour pressure profile without and during treatment with beta-blockers or cyproheptadine].
Studying a patient with Cushing's disease by 24-hour indirect blood pressure monitoring, we confirmed that the normal nocturnal fall in blood pressure was absent, although the usual decrease in heart rate persisted. Thereafter we found a hypervariability in blood pressure and heart rate, which was reversed by treatment with betablockers and/or cyproheptadine. The therapy restored also the normal nocturnal fall in blood pressure. The low-dose cyproheptadine therapy normalized urinary free cortisol levels and restored a 24-hour blood pressure profile better than the low-dose beta-blocker therapy.
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I Unità Operativa Medicina Generale, Ospedale Degli Infermi di San Miniato, PI.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D015924:Blood Pressure Monitors; D002940:Circadian Rhythm / Q000187:drug effects*; D003480:Cushing Syndrome / Q000150:complications* / Q000503:physiopathology; D003533:Cyproheptadine / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged
D000319:Adrenergic beta-Antagonists; D003533:Cyproheptadine
L'ipertensione arteriosa nel morbo di Cushing: profilo pressorio delle 24 ore senza e durante trattamento con betabloccanti o ciproeptadina.