title: Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation.
abstract: Identification of a biocompatible immunoprotective membrane to prevent graft rejection remained elusive until the development of microcapsules formulated in alginate high in guluronic acid. We report insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Encapsulated human islets were injected intraperitoneally in a diabetic patient with a functioning kidney graft. Insulin independence with tight glycaemic control was demonstrated 9 months after the procedure. These results warrant a trial of a high dose of encapsulated islets in early-onset diabetic patients.
authors.affiliation: St Vincent Medical Center, Los Angeles, CA 90057.
authors.forename: P
authors.initials: P
authors.lastname: Soon-Shiong
authors.forename: R E
authors.initials: RE
authors.lastname: Heintz
authors.forename: N
authors.initials: N
authors.lastname: Merideth
authors.forename: Q X
authors.initials: QX
authors.lastname: Yao
authors.forename: Z
authors.initials: Z
authors.lastname: Yao
authors.forename: T
authors.initials: T
authors.lastname: Zheng
authors.forename: M
authors.initials: M
authors.lastname: Murphy
authors.forename: M K
authors.initials: MK
authors.lastname: Moloney
authors.forename: M
authors.initials: M
authors.lastname: Schmehl
authors.forename: M
authors.initials: M
authors.lastname: Harris
mesh_terms: D000328:Adult; D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D006801:Humans; D007274:Injections, Intraperitoneal; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008297:Male; D011184:Postoperative Period
chemical_list: D001786:Blood Glucose