Extravascular proteolysis and the nervous system: serine protease/serpin balance.
Widely recognized as components of the blood coagulation cascade, serine proteases and their natural inhibitors, specific serpins known as the protease nexins, also regulate the maintenance of normal function in the nervous system. Increasingly, evidence has accumulated as to regulation of their synthesis and functional roles within both the CNS and peripheral nervous system. Our review focuses on the localization and activity of TH and PN I in the nervous system, as well as on the impact of the protease/inhibitor balance for the pathogenesis of neurodegenerative disorders such as AD.
Smirnova
I V
IV
Neurobiology Research Laboratory, Veterans Affairs Medical Center, Kansas City, Missouri 64128.
Ho
G J
GJ
Fenton
J W
JW
Festoff
B W
BW
D016564:Amyloid beta-Protein Precursor; D000818:Animals; D002352:Carrier Proteins / Q000032:analysis; D002455:Cell Division / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009420:Nervous System / Q000098:blood supply / Q000378:metabolism*; D058255:Protease Nexins; D011956:Receptors, Cell Surface; D012697:Serine Endopeptidases / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism*; D013917:Thrombin / Q000032:analysis / Q000037:antagonists & inhibitors
D016564:Amyloid beta-Protein Precursor; D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; D058255:Protease Nexins; D011956:Receptors, Cell Surface; D015843:Serpins; D012697:Serine Endopeptidases; D013917:Thrombin