[The dermal dendrocyte].
Dermal dendrocytes represent a population of resident cells of the dermis identified recently by virtue of the immunohistochemical expression of the coagulation factor XIIIa (fXIIIa). These dendritic cells of bone-marrow origin bear particular histoenzymatic and immunohistochemical features, some of which are shared with antigen-presenting cells; however, they are clearly distinct from epidermal Langerhans cells. Dermal dendrocytes could act as macrophages, antigen-presenting cells or participate in the homeostasis of macromolecules of the dermis. These cells give rise to some cutaneous tumours and seem involved in inflammatory dermatoses where they act by means of cytokine production; they could even represent targets of HIV infection. Future functional studies will hopefully lead to a better understanding of their precise role in normal and diseased skin, which remains presently partly speculative.
Hoyo
E
E
INSERM U.346, Laboratoire d'Anatomie Pathologique, Hôpital Ed. Herriot, Lyon, France.
Kanitakis
J
J
Schmitt
D
D
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000503:physiopathology; D016207:Cytokines / Q000494:pharmacology; D003872:Dermatitis / Q000503:physiopathology; D006099:Granuloma / Q000503:physiopathology; D006684:HLA-DR Antigens / Q000276:immunology; D018219:Histiocytoma, Benign Fibrous / Q000503:physiopathology / Q000648:ultrastructure; D006801:Humans; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000503:physiopathology; D012867:Skin / Q000033:anatomy & histology; D012878:Skin Neoplasms / Q000503:physiopathology / Q000648:ultrastructure; D012879:Skin Physiological Phenomena; D011503:Transglutaminases / Q000502:physiology*; D014212:Tretinoin / Q000494:pharmacology; D014466:Ultraviolet Rays; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000503:physiopathology
D016207:Cytokines; D006684:HLA-DR Antigens; D014212:Tretinoin; D011503:Transglutaminases
Le dendrocyte dermique.