title: Genotyping and association analysis of HLA-B61 in Japanese.
abstract: The distribution of HLA-B61-related alleles, B*4002-B*4006, was examined in the Japanese population by using PCR-SSO and PCR-RFLP methods. About half of the B61-positive individuals possessed B*4002 and the remaining half possessed B*4006. In addition, these two major B61 alleles were separately associated with different HLA-C alleles: B*4002 exhibited a strong linkage disequilibrium with Cw10, whereas B*4006 was strongly associated with C blank and DR9. Amino acid residues that contribute to the serologic epitopes of the B61 group and their relationships with other HLA-B locus antigens are discussed.
authors.affiliation: Department of Transfusion Medicine and Immunohematology Faculty of Medicine, University of Tokyo, Japan.
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.forename: K
authors.initials: K
authors.lastname: Tokunaga
authors.forename: A
authors.initials: A
authors.lastname: Ogawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Kashiwase
authors.forename: T
authors.initials: T
authors.lastname: Akaza
authors.forename: S
authors.initials: S
authors.lastname: Kuwata
authors.forename: K
authors.initials: K
authors.lastname: Tadokoro
authors.forename: T
authors.initials: T
authors.lastname: Juji
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D016384:Consensus Sequence; D004247:DNA; D004591:Electrophoresis, Polyacrylamide Gel; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017386:Sequence Homology, Amino Acid
chemical_list: D015235:HLA-B Antigens; C079077:HLA-B61 antigen; D015345:Oligonucleotide Probes; D004247:DNA