[Myocardial protection in the patient with angina: bases for a personalized treatment].
Secondary cardioprotection of patients with angina pectoris can be accomplished by selecting appropriate drugs for the specific clinical setting. Calcium-antagonists are the first choice drugs in patients with vasospastic angina or in those clinical situations in which vasoconstriction plays a significant pathogenetic role. On the contrary beta-blockers reduce mortality and the probability of myocardial infarction in patients with unstable angina. The beneficial effects of aspirin on survival of patients with unstable angina is also well known, whereas ACE-inhibitors reduce mortality as well as the incidence of unstable angina in patients with ischemic cardiomyopathy. Also nonpharmacologic treatments (physical exercise, preconditioning) may have beneficial effects although their role is not well established yet.
De Servi
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Divisione di Cardiologia, IRCCS, Policlinico San Matteo, Pavia.
Mariani
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G
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D006332:Cardiomegaly / Q000188:drug therapy; D004967:Estrogens / Q000627:therapeutic use; D015444:Exercise; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D017682:Myocardial Stunning / Q000188:drug therapy
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers; D004967:Estrogens; D005343:Fibrinolytic Agents
La protezione micocardica del paziente anginoso: basi di una terapia personalizzata.