Leishmania amazonensis: sensitivity of different promastigote morphotypes to salivary gland homogenates of the sand fly Lutzomyia longipalpis.
We have recently demonstrated that Lutzomyia longipalpis salivary gland homogenates (SGH) inhibited the multiplication of Leishmania promastigotes in vitro. The present work shows that Leishmania amazonensis sensitivity to SGH is correlated to the phase of promastigote in vitro growth and can be decreased by the addition of hemin to the culture medium. The possible relevance of these in vitro results is discussed in relation to the development of Leishmania parasites within their sand fly vectors.
Charlab
R
R
Department of Entomology, University of Arizona, Tucson 85721.
Tesh
R B
RB
Rowton
E D
ED
Ribeiro
J M
JM
D000818:Animals; D003470:Culture Media; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006427:Hemin / Q000494:pharmacology; D007303:Insect Vectors / Q000276:immunology / Q000469:parasitology*; D007894:Leishmania mexicana / Q000187:drug effects / Q000254:growth & development / Q000276:immunology*; D011576:Psychodidae / Q000276:immunology / Q000469:parasitology*; D012469:Salivary Glands / Q000276:immunology
D003470:Culture Media; D006427:Hemin