[The genotype of CYP2E1 and liver-derived serum enzymes].
We determined the genotypes of the CYP2E1 loci of Japanese alcoholics with or without liver dysfunction to investigate the relationship between CYP2E1 and the susceptibility to alcoholic liver-injury. In the alcoholics (DSM-III-R) with a liver dysfunction, there was a significant relationship between the serum concentration of a liver-derived serum enzyme LAP and the C2 allele of CYP2E1.
Iwahashi
K
K
Department of Neuropsychiatry, Kagawa Medical School, Japan.
Miyatake
R
R
Suwaki
H
H
Nakamura
K
K
Orino
K
K
D000410:Alanine Transaminase / Q000097:blood; D000437:Alcoholism / Q000201:enzymology* / Q000235:genetics*; D001219:Aspartate Aminotransferases / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008108:Liver Diseases, Alcoholic / Q000201:enzymology* / Q000235:genetics*; D005723:gamma-Glutamyltransferase / Q000097:blood
D003577:Cytochrome P-450 Enzyme System; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007931:Leucyl Aminopeptidase