Interactions among deprenyl, clorgyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on catecholamines in mice.
The interactive effects of clorgyline, deprenyl and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal dopamine (DA), serotonin (5HT) and hippocampal norepinephrine (NE) were examined in the present study. Results indicated that clorgyline did not have a preventive effect against MPTP's toxicity on DA and NE, but it had a partial therapeutic effect against subchronic MPTP-induced DA depletion when given with deprenyl together. However, this effect was not significantly different from the effect of deprenyl alone. Co-administration of clorgyline and deprenyl had a satisfactory effect in preventing MPTP-induced NE depletion. On the other hand, in all clorgyline-treated groups, there was a significant increase of 5HT in both the striatum and the hippocampus.
Lee
E H
EH
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
Yang
Y L
YL
Chia
L G
LG
Kuo
J S
JS
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D003010:Clorgyline / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000633:toxicity; D004347:Drug Interactions; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D012642:Selegiline / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism
D002395:Catecholamines; D015259:Dopamine Agents; C048977:1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine; D012642:Selegiline; D012701:Serotonin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D003010:Clorgyline; D004298:Dopamine; D009638:Norepinephrine