Comparison of distribution of brush-border exo- and endopeptidases in rat and rabbit intestine.
The distribution of brush-border endopeptidase-2, aminopeptidase W, carboxypeptidase P, and aminopeptidase P along the rat and rabbit intestine was examined. In both species, aminopeptidases P and W increased distally and reached the highest in the ileum; their activities in the ileo-caecal junction were the lowest. Endopeptidase-2 had a uniform intestinal distribution in both species with the highest activity in the ileum and little activity in the ileo-caecal junction or caecum. With a distribution similar to that of endopeptidase-2, carboxypeptidase P also had high activity in the ileum in rats and rabbits.
Bai
J P
JP
College of Pharmacy, University of Minnesota, Minneapolis 55455.
D000818:Animals; D002432:Cecum / Q000201:enzymology / Q000648:ultrastructure; D002851:Chromatography, High Pressure Liquid; D010450:Endopeptidases / Q000378:metabolism; D007082:Ileum / Q000201:enzymology / Q000648:ultrastructure; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D008871:Microvilli / Q000201:enzymology; D010447:Peptide Hydrolases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013056:Spectrophotometry, Ultraviolet
D010450:Endopeptidases; D010447:Peptide Hydrolases