title: Pigeon and dove eggwhite protect mice against renal infection due to P fimbriated Escherichia coli.
abstract: Pigeon and dove eggwhite exhibit high level P1 antigenic activity and are potent and specific inhibitors of adherence mediated by P fimbriae of uropathogenic Escherichia coli. To evaluate pigeon and dove eggwhite as P fimbrial receptor analogues in the prevention of ascending renal infection, mice were challenged with a P fimbriated E. coli urosepsis isolate suspended in saline alone or in saline plus various inhibitors of adherence, including D-mannose, globoside, and chicken, dove, and pigeon eggwhite. D-mannose inhibited mannose-sensitive adherence but not P fimbrial adherence, and failed to prevent renal infection. Globoside and chicken eggwhite also failed to inhibit P fimbrial adherence; chicken eggwhite had little and globoside had no impact on renal infection. In contrast, dove and pigeon eggwhite eliminated P fimbrial adherence and significantly reduced the incidence and intensity of renal infection. These findings suggest that pigeon and dove eggwhite provide P1-antigen-specific protection against ascending renal infection in mice due to P fimbriated uropathogenic E. coli.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis 55455.
authors.forename: J R
authors.initials: JR
authors.lastname: Johnson
authors.forename: T
authors.initials: T
authors.lastname: Berggren
mesh_terms: D000368:Aged; D000371:Agglutination; D000818:Animals; D002645:Chickens; D010856:Columbidae; D004529:Egg White; D004926:Escherichia coli / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000517:prevention & control*; D005260:Female; D010861:Fimbriae, Bacterial; D006801:Humans; D007674:Kidney Diseases / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014552:Urinary Tract Infections / Q000517:prevention & control*