title: Eyelid involvement in multicentric reticulohistiocytosis.
abstract: METHODS
  The authors report the first biopsy-confirmed ocular adnexal involvement by multicentric reticulohistiocytosis. The patient was a 28-year-old black woman with a 15-year history of well-documented multicentric reticulohistiocytosis who had multiple dermal nodules and severe mutilating arthritis that had produced a characteristic telescoping deformity of the digits. Eyelid nodules were excised to relieve pseudoptosis and for cosmesis.
  
  
  METHODS
  The eyelid nodules were studied by routine light microscopy and a battery of immunohistochemical stains, including S-100 protein and several macrophage markers.
  
  
  RESULTS
  Microscopy disclosed an infiltrate of histiocytes and giant cells with glassy eosinophilic cytoplasm and large round or oval vesicular nuclei with prominent nucleoli set in a densely fibrotic stroma consistent with multicentric reticulohistiocytosis. The histiocytes showed positive immunoreactivity for lysozyme, but were negative for alpha-1 antichymotrypsin, S-100 protein, and neuron-specific enolase.
  
  
  CONCLUSIONS
  Multicentric reticulohistiocytosis should be included in the differential diagnosis of multiple eyelid nodules.
authors.affiliation: Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107.
authors.forename: R C
authors.initials: RC
authors.lastname: Eagle
authors.forename: R A
authors.initials: RA
authors.lastname: Penne
authors.forename: I S
authors.initials: IS
authors.lastname: Hneleski
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D005141:Eyelid Diseases / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000737:chemistry / Q000473:pathology; D006225:Hand; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D012871:Skin Diseases / Q000473:pathology*
chemical_list: D015415:Biomarkers