Serum iron abnormalities in neuroleptic-induced akathisia in schizophrenic patients.
Twenty-two schizophrenic patients (DSM-III-R criteria) with clinically significant akathisia were matched with 22 schizophrenic patients without akathisia on the following variables: age, sex, diagnosis, duration of illness, and current treatment. Both groups were assessed using a variety of clinical rating scales and several parameters of serum iron status. The akathisic patients showed greater severity of clinical psychopathology, particularly positive symptoms, and an excess of extrapyramidal side-effects. We were unable to confirm any association between low serum iron and neuroleptic-induced akathisia in our sample of community-based patients.
Soni
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SD
Department of Psychological Medicine, University of Manchester School of Medicine, Hope Hospital, Salford.
Tench
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Routledge
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D000328:Adult; D000368:Aged; D017109:Akathisia, Drug-Induced / Q000175:diagnosis*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001774:Blood Chemical Analysis; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*
D014150:Antipsychotic Agents; D007501:Iron