title: The trypanocidal effect of Cannabis sativa constituents in experimental animal trypanosomiasis.
abstract: The effect of Cannabis sativa on trypanosome-infected rats was examined. An aqueous extract of the seeds administered at a dose of 50 mg/kg/d cured animals infected with Trypanosome brucei brucei of blood stream parasites. Six fractions eluted from the crude extract by column chromatography were assessed for trypanocidal properties. Of these, only 2 fractions retained trypanocidal activity by curing mice infected with T brucei brucei.
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
authors.forename: A J
authors.initials: AJ
authors.lastname: Nok
authors.forename: S
authors.initials: S
authors.lastname: Ibrahim
authors.forename: S
authors.initials: S
authors.lastname: Arowosafe
authors.forename: I
authors.initials: I
authors.lastname: Longdet
authors.forename: A
authors.initials: A
authors.lastname: Ambrose
authors.forename: P C
authors.initials: PC
authors.lastname: Onyenekwe
authors.forename: C Z
authors.initials: CZ
authors.lastname: Whong
mesh_terms: D000818:Animals; D002186:Cannabinoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002188:Cannabis / Q000737:chemistry*; D005591:Chemical Fractionation; D002845:Chromatography; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012639:Seeds / Q000737:chemistry; D014346:Trypanosoma brucei brucei / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
chemical_list: D002186:Cannabinoids; D010936:Plant Extracts