title: Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes.
abstract: We have observed five children with cystic fibrosis, who presented over 2 months, with meconium ileus equivalent that failed to respond to medical management. At surgery, four had a stricture in the ascending colon, and all had histopathological changes of post-ischaemic ulceration repair, with mucosal and submucosal fibrosis. The only common change in the management of these children was a switch from conventional enteric-coated pancreatic enzymes to high-strength products 12-15 months before presentation.
authors.affiliation: Respiratory Unit, Royal Liverpool Children's Hospital, Alder Hey, UK.
authors.forename: R L
authors.initials: RL
authors.lastname: Smyth
authors.forename: D
authors.initials: D
authors.lastname: van Velzen
authors.forename: A R
authors.initials: AR
authors.lastname: Smyth
authors.forename: D A
authors.initials: DA
authors.lastname: Lloyd
authors.forename: D P
authors.initials: DP
authors.lastname: Heaf
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000473:pathology; D003108:Colonic Diseases / Q000209:etiology* / Q000473:pathology; D003251:Constriction, Pathologic / Q000139:chemically induced; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy; D005355:Fibrosis / Q000139:chemically induced; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology* / Q000473:pathology; D008049:Lipase / Q000009:adverse effects; D008297:Male; D008470:Meconium; D010184:Pancreatic Extracts / Q000009:adverse effects*; D010194:Pancreatin / Q000009:adverse effects; D020799:Pancrelipase
chemical_list: D010184:Pancreatic Extracts; D020799:Pancrelipase; D010194:Pancreatin; D008049:Lipase