Long-term potentiation in the auditory cortex of adult rats.
Long-term potentiation (LTP) in the auditory cortex was studied in slices obtained from adult rats. White matter stimulation produced field potentials in layers II/III, which were composed of two negative waves followed by a slow positivity. The second negative and third positive waves were blocked by a low Ca2+ (0.48 mM) medium or by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 microM), while the first negativity unchanged. D-2-amino-5-phosphonovalerate (D-AP5, 50 microM) showed no clear effect on the field potentials. Tetanic stimulation of the white matter produced potentiation in the second negativity, and the potentiation was maintained for at least 30 min. D-AP5 blocked this potentiation completely. These data indicate that LTP is evoked by activation of N-methyl-D-aspartate (NMDA) receptors in the auditory cortex of adult rats.
Kudoh
M
M
Department of Neurophysiology, Brain Research Institute, Niigata University, Japan.
Shibuki
K
K
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects / Q000502:physiology*; D002118:Calcium / Q000502:physiology; D004558:Electric Stimulation; D004566:Electrodes; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D011810:Quinoxalines; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D015763:2-Amino-5-phosphonovalerate; D002118:Calcium