title: A prospective randomized double-blinded study of the effect of intravenous fluid therapy on adverse outcomes on outpatient surgery.
abstract: This study investigated the impact of perioperative fluid status on adverse clinical outcomes in ambulatory surgery. Two hundred ASA grade I-III ambulatory surgical patients were prospectively randomized into two groups to receive high (20 mL/kg) or low (2 mL/kg) infusions of isotonic electrolyte solution over 30 min preoperatively. A standardized balanced anesthetic was used. A minimal amount of fluid was given during the intraoperative and postoperative periods. Adverse outcomes were assessed by an investigator blinded to the fluid treatment group at 30 and 60 min after surgery, at discharge, and the first postoperative day. The incidence of thirst, drowsiness, and dizziness was significantly lower in the high-infusion group at all intervals. We recommend perioperative hydration of 20 mL/kg for patients undergoing general anesthesia for short ambulatory surgery.
authors.affiliation: Department of Anaesthesia, University of Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Yogendran
authors.forename: B
authors.initials: B
authors.lastname: Asokumar
authors.forename: D C
authors.initials: DC
authors.lastname: Cheng
authors.forename: F
authors.initials: F
authors.lastname: Chung
mesh_terms: D000085:Acetates / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000768:Anesthesia, General; D004244:Dizziness / Q000517:prevention & control; D004311:Double-Blind Method; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D005942:Gluconates / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D015636:Magnesium Chloride / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control; D011183:Postoperative Complications; D011189:Potassium Chloride / Q000008:administration & dosage; D011300:Preoperative Care; D011446:Prospective Studies; D012894:Sleep Stages; D019346:Sodium Acetate; D012965:Sodium Chloride / Q000008:administration & dosage; D013894:Thirst
chemical_list: D000085:Acetates; D005942:Gluconates; C012499:Plasma-lyte 148; D015636:Magnesium Chloride; D012965:Sodium Chloride; D019346:Sodium Acetate; D011189:Potassium Chloride