title: PstI restriction fragment length polymorphism of the human intestinal alkaline phosphatase gene.
abstract: Restriction fragment length polymorphisms have previously been found in the placental alkaline phosphatase (PLAP) and germ cell alkaline phosphatase (GCAP) genes, but not in the closely related intestinal alkaline phosphatase (IAP) locus. We here report on a PstI restriction fragment length polymorphism in IAP found in Finns and Swedes but not in Saamis. A probable T-->G mutation in position 175 of intron 11 would create a new cleavage site for PstI. The borderline frequency of the mutant allele (0.01) is in agreement with previous observations suggesting that IAP is considerably less polymorphic than PLAP and GCAP.
authors.affiliation: Department of Medical Genetics, University of Umeå, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Beckman
authors.forename: L
authors.initials: L
authors.lastname: Beckman
authors.forename: C
authors.initials: C
authors.lastname: Wennberg
authors.forename: C
authors.initials: C
authors.lastname: Sikström
authors.forename: J L
authors.initials: JL
authors.lastname: Millán
mesh_terms: D000469:Alkaline Phosphatase / Q000235:genetics*; D000483:Alleles; D015252:Deoxyribonucleases, Type II Site-Specific; D005387:Finland; D005787:Gene Frequency; D005796:Genes; D006801:Humans; D007422:Intestines / Q000201:enzymology*; D007527:Isoenzymes / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D013548:Sweden
chemical_list: D007527:Isoenzymes; C024388:CTGCAG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific; D000469:Alkaline Phosphatase