Awareness of and memory for arm weakness during intracarotid sodium amytal testing.
The traditional association between anosognosia for hemiplegia and the right hemisphere was investigated in 31 patients with unilateral temporal lobe pathology during intracarotid sodium amytal testing (ISA) before epilepsy surgery. Recall of arm weakness was examined by questioning at the end of the test, when memory for items presented during the hemiplegia was also examined. Significantly more patients were amnesic for left arm weakness than for right. Amnesia for right arm weakness (and speech arrest) was significantly associated with pathology in the temporal lobe on the non-injected side and with impaired recognition of the memory items. Amnesia for left arm weakness was independent of both. Examination of cases where injection was contralateral to a hemisphere without pathology, and which showed normal memory capacity under ISA conditions, revealed that 87% recalled right arm weakness, but only 22% recalled left arm weakness. Awareness of arm weakness during left hemiplegia was examined in nine patients. Five of them were not aware of the weakness. Three of the four others could not subsequently recall it. By inference from the generally unimpaired recall of right arm weakness, following left hemisphere inactivation by amytal, an intact right hemisphere is capable of both recognizing right arm weakness and mediating its subsequent recall. In contrast, the left hemisphere was aware of left arm weakness only in approximately 50% of cases and even when there had been awareness usually could not mediate its subsequent recall. The suggestion is made that the right hemisphere may have a specific mnestic function for arm weakness, and presumably for hemiplegia, additional to the gnostic function.
Carpenter
K
K
Department of Clinical Neuropsychology, Radcliffe Infirmary, Oxford, UK.
Berti
A
A
Oxbury
S
S
Molyneux
A J
AJ
Bisiach
E
E
Oxbury
J M
JM
D000293:Adolescent; D000328:Adult; D000654:Amobarbital / Q000008:administration & dosage*; D001132:Arm; D001364:Awareness / Q000187:drug effects*; D003717:Denial, Psychological; D004292:Dominance, Cerebral; D005260:Female; D006429:Hemiplegia / Q000523:psychology*; D006801:Humans; D008297:Male; D008568:Memory
D000654:Amobarbital