[A statistical analysis of the results obtained with anti-PCNA/cyclin monoclonal antibody in pulmonary epidermoid carcinomas].
The reaction of PCNA/cyclin protein with anti-PCNA/cyclin monoclonal antibody was positive for most tumoral cells in all types of lung epidermoid carcinomas. The strongest positive reaction characterized the well differentiated epidermoid carcinomas. A constantly strong positive reaction towards anti-PCNA/cyclin was noticed in all multinucleate giant cells of this type of carcinoma. The reaction is also topographically uniform. This heterogeneity can be explained by the asynchronous rhythm division of malignant cells from the various areas of the tumor, or can be due to some cells of different origin and histomorphology, present within the same tumoral mass. Nuclear PCNA/cyclin immunoreactivity can offer information on the proliferation index, that is indirectly on tumor prognosis. This method supports previous assertions that well differentiated epidermoid carcinomas have the best prognosis, while the undifferentiated forms with giant cells have the poorest prognosis.
Niţă
M
M
Disciplina de Histologie, Universitatea de Medicină şi Farmacie Iaşi.
Gasser
B
B
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000276:immunology*; D009687:Nuclear Proteins / Q000276:immunology*; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen; D013223:Statistics as Topic
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D001324:Autoantigens; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen
Analiza statistică a rezultatelor obţinute cu anticorpul monoclonal anti-PCNA/cyclin în carcinoamele epidermoide pulmonare.