CD4 negative mice as a model for immunodeficiency.
CD4 is a co-receptor required for T cell helper functions. A mouse strain without CD4 expression has been generated. These animals, surprisingly have a normal CTL response and reduced, but not absent, humoral responses. A new population of MHC class II restricted CD4-CD8-TcR alpha beta+ T cells has emerged which possess helper function potential. These findings have important implications on disease situations where CD4 cells are decreased or absent.
Rahemtulla
A
A
Amgen Institute, Toronto, Ontario, Canada.
Shahinian
A
A
Kundig
T
T
Zinkernagel
R
R
Mak
T W
TW
D000818:Animals; D000917:Antibody Formation; D015704:CD4 Antigens / Q000235:genetics*; D016827:CD8 Antigens / Q000032:analysis; D004195:Disease Models, Animal; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology*; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D015704:CD4 Antigens; D016827:CD8 Antigens