title: Occlusivity and effects of two occlusive dressings on normal human skin.
abstract: Two occlusive, adhesive dressings--one hydrocolloid (absorptive) and one zinc-medicated (non-absorptive)--were studied regarding their occlusivity and effects when applied to normal human skin for 48 h. Both dressings reduced normal transepidermal water loss by about 70%. As documented by a 7-fold increase in the water loss beneath the dressings compared to untreated skin, water was retained in the stratum corneum by both dressings. No appreciable influence of either dressing on skin temperature was found. The skin surface pH decreased beneath the hydrocolloid while it increased beneath the zinc dressing.
authors.affiliation: Department of Pathology, Faculty of Health Sciences, Mölnlycke, Sweden.
authors.forename: M S
authors.initials: MS
authors.lastname: Agren
authors.forename: C
authors.initials: C
authors.lastname: Wijesinghe
mesh_terms: D000328:Adult; D047070:Bandages, Hydrocolloid; D003102:Colloids / Q000494:pharmacology*; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009779:Occlusive Dressings; D010539:Permeability / Q000187:drug effects; D011143:Polyvinyl Chloride / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D012881:Skin Temperature / Q000187:drug effects; D013997:Time Factors; D014870:Water Loss, Insensible / Q000187:drug effects; D015034:Zinc Oxide / Q000494:pharmacology*
chemical_list: D003102:Colloids; C086551:Mezinc; D011143:Polyvinyl Chloride; D015034:Zinc Oxide