title: The treatment of early squamous cell carcinoma of the piriform fossa.
abstract: The treatment of early piriform fossa cancer can be either primary radiotherapy with salvage surgery, if necessary, or with primary surgery. The present study investigates 65 patients with T1, > or = 2 or T3 stage disease with no cervical lymph node metastases at presentation. Of this group, 17 were treated by primary irradiation, 34 underwent primary surgery and 14 were unsuitable for any curative treatment. The adjusted actuarial 5-year survival rate for those patients receiving primary radiotherapy was 55% (95% CI 16-78%) and for the surgery group it was 44% (95% CI 18-67%). This difference was not significant (chi 2(1) = 1.29). The median survival for untreated patients was 7 months (4-12 months). There was no significant differences in the time to recurrence at the primary site or in the neck, or in survival after recurrence at these sites. Thirty-five per cent of patients treated by primary irradiation were controlled at the primary site compared with 68% in the surgical group. Failure in the neck was similar for the two groups at 12% and 15% respectively. Salvage surgery was effective for the radiotherapy group with eight out of 11 patients being suitable for treatment. In the final analysis in the radiotherapy group two patients were alive and with their larynx and two alive without their larynx, the remainder of patients having died from the original tumour, intercurrent disease or second primary tumours. The survival figures for the surgery group were proportionately similar except of course, that all patients had lost their larynx.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Otorhinolaryngology, University of Liverpool, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Jones
authors.forename: A
authors.initials: A
authors.lastname: Wilde
authors.forename: R D
authors.initials: RD
authors.lastname: McRae
authors.forename: D E
authors.initials: DE
authors.lastname: Phillips
authors.forename: J K
authors.initials: JK
authors.lastname: Field
authors.forename: D G
authors.initials: DG
authors.lastname: Husband
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods; D015993:Life Tables; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology; D010610:Pharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D010611:Pharyngectomy / Q000379:methods; D016879:Salvage Therapy; D015996:Survival Rate; D017211:Treatment Failure