title: Atrial natriuretic peptide inhibited the natriferic and hydrosmotic effects of arginine vasotocin on toad skin.
abstract: The effect of rat atrial natriuretic peptide (rANP) on hormonal stimulated osmotic water permeability (Jw, hydrosmotic effect) and net ion transport (short-circuit current, SCC, natriferic effect) was studied on toad skin, a tissue with functional similarities to the mammalian distal nephron, in order to assess actions on transport mechanisms. Rat atrial natriuretic peptide, rANP-99-126 (rANP) inhibited stimulated SCC and Jw to submaximal concentrations of arginine vasotocin (AVT) at a site before cyclic AMP generation. The angiotensin-converting enzyme inhibitor (ACEI) MK-422 did not modify the inhibitory effect of ANP in the stimulated Jw.
authors.affiliation: Departamento de Fisiología, INSIBIO, San Miguel de Tucumán, Argentina.
authors.forename: D M
authors.initials: DM
authors.lastname: Berman
authors.forename: M O
authors.initials: MO
authors.lastname: Soria
authors.forename: M
authors.initials: M
authors.lastname: Proto de Grifasi
authors.forename: A
authors.initials: A
authors.lastname: Coviello
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003994:Bucladesine / Q000494:pharmacology; D002022:Bufo arenarum; D000242:Cyclic AMP / Q000096:biosynthesis; D015773:Enalaprilat / Q000494:pharmacology; D005260:Female; D017136:Ion Transport / Q000187:drug effects; D008297:Male; D009995:Osmosis / Q000187:drug effects; D010539:Permeability / Q000187:drug effects; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology; D014668:Vasotocin / Q000037:antagonists & inhibitors* / Q000494:pharmacology
chemical_list: D003994:Bucladesine; D009320:Atrial Natriuretic Factor; D012964:Sodium; D013806:Theophylline; D000242:Cyclic AMP; D015773:Enalaprilat; D014668:Vasotocin