title: Macromolecular crowding and molecular recognition.
abstract: The effects of macromolecular crowding upon macromolecular associations in solution, and upon binding of a macromolecular ligand to a surface site, are reviewed. It is demonstrated, by means of two examples, that crowding may lead to significant alterations of biochemical or biological recognition processes at the molecular level.
authors.affiliation: Section on Physical Biochemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
authors.forename: A P
authors.initials: AP
authors.lastname: Minton
mesh_terms: D001665:Binding Sites; D001667:Binding, Competitive; D066298:In Vitro Techniques; D008024:Ligands; D046911:Macromolecular Substances; D008954:Models, Biological; D008956:Models, Chemical; D011991:Receptors, Virus / Q000502:physiology; D012996:Solutions; D013816:Thermodynamics
chemical_list: D008024:Ligands; D046911:Macromolecular Substances; D011991:Receptors, Virus; D012996:Solutions