The effect of a nutritional model of chronic liver injury on the hepatic glucuronidation of morphine in rats.
The effect of a choline-deficient diet on the hepatic glucuronidation of morphine was investigated using a rat perfused liver system. Rats fed a choline-deficient diet developed a fatty liver with minimal necrosis. Despite the morphological changes, neither hepatic extraction ratio (0.51 +/- 0.02 in control; 0.45 +/- 0.04 in the choline-deficient rats) nor intrinsic clearance (0.85 +/- 0.05 in control; 0.77 +/- 0.09 in choline-deficient rats) were affected by this injury model. This finding suggests that glucuronidation is relatively resistant to this chronic liver injury.
Callaghan
R
R
Department of Clinical Pharmacology, St Vincent's Hospital, Fitzroy, Victoria, Australia.
Desmond
P V
PV
Mashford
M L
ML
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002796:Choline Deficiency / Q000378:metabolism* / Q000473:pathology; D002851:Chromatography, High Pressure Liquid; D005234:Fatty Liver / Q000378:metabolism* / Q000473:pathology; D005965:Glucuronates / Q000378:metabolism; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D009020:Morphine / Q000493:pharmacokinetics*; D009929:Organ Size / Q000502:physiology; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats
D005965:Glucuronates; D007773:Lactates; D011773:Pyruvates; D009020:Morphine; D019289:Pyruvic Acid