title: NPY-induced neurotransmitter release from the rabbit and chicken retina.
abstract: Neuropeptide Y (NPY) or closely related peptides are present in the retina of certain vertebrates, but their actions are not known. We have therefore studied the NPY-induced release of [3H]-GABA, [3H]-glycine, [3H]-dopamine, [3H]-5-hydroxytryptamine, and [3H]-choline chloride-derived radioactivity in the rabbit and chicken retina. NPY affected the release of [3H]-glycine, [3H]-dopamine, [3H]-5-hydroxytryptamine, and [3H]-choline chloride-derived radioactivity in rabbit retina and of [3H]-GABA, [3H]-5-hydroxytryptamine and [3H]-choline chloride-derived radioactivity in chicken retina in an energy requiring, NA+K(+)-ATPase dependent and calcium dependent manner. Certain related peptides, APP (= avian pancreatic polypeptide), BPP (= bovine pancreatic polypeptide), and PYY (= peptide YY), had variable and less pronounced effects. The results suggest a neurophysiological role in both chicken and rabbit retina for NPY or some related peptide.
authors.affiliation: Department of Ophthalmology, University of Lund, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Bruun
authors.forename: B
authors.initials: B
authors.lastname: Ehinger
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D009478:Neuropeptide Y / Q000494:pharmacology* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000096:biosynthesis*; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D009478:Neuropeptide Y; D018377:Neurotransmitter Agents; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium