title: IgG monoclonal antibodies that inhibit osteoinductivity of human bone matrix-derived proteins (hBMP/NCP).
abstract: Monoclonal hBMP/NCP (human bone morphogenetic protein and associated noncollagenous proteins) antibodies of the IgG class were produced. In vitro, 12 of 19 hBMP/NCP antibodies showed functional inhibition of hBMP/NCP-induced chondroneogenesis in a neonatal muscle tissue assay. Inducing factors were characterized by their inhibiting antibodies with immunoblotting. Several peptide factors seem to be involved in the cascade of induced chondro- and osteogenesis.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Würzburg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Kübler
authors.forename: J
authors.initials: J
authors.lastname: Reuther
authors.forename: T
authors.initials: T
authors.lastname: Kirchner
authors.forename: M
authors.initials: M
authors.lastname: Pfaff
authors.forename: H K
authors.initials: HK
authors.lastname: Müller-Hermelink
authors.forename: R
authors.initials: R
authors.lastname: Albert
authors.forename: W
authors.initials: W
authors.lastname: Sebald
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001857:Bone Matrix / Q000737:chemistry* / Q000502:physiology; D019485:Bone Morphogenetic Proteins; D002356:Cartilage / Q000254:growth & development; D016326:Extracellular Matrix Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D006131:Growth Inhibitors / Q000737:chemistry / Q000276:immunology*; D006133:Growth Substances / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G; D051379:Mice; D008807:Mice, Inbred BALB C; D010012:Osteogenesis / Q000187:drug effects*; D011506:Proteins / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D000911:Antibodies, Monoclonal; D019485:Bone Morphogenetic Proteins; D016326:Extracellular Matrix Proteins; D006131:Growth Inhibitors; D006133:Growth Substances; D007074:Immunoglobulin G; D011506:Proteins