A new experimental model: for further investigation of the secondary changes following spinal cord injury.
To investigate the pathophysiology of spinal trauma, several experimental models have been used. In this study, the authors present a new experimental model for further investigation of secondary damage following spinal injury. Nd:YAG laser irradiation was applied to the spinal cord of guinea pigs to produce an injury. A 30 Watt (20 Joule) laser produced paraparesis. The injury was evaluated with evoked potentials, lipid peroxidation values, and histopathological examination.
Colak
A
A
Department of Neurosurgery, Hacettepe University, Ankara, Turkey.
Nurlu
G
G
Açikgöz
B
B
Ozcan
O E
OE
Aydim
E
E
D000818:Animals; D004195:Disease Models, Animal; D005073:Evoked Potentials, Somatosensory; D006168:Guinea Pigs; D007834:Lasers / Q000009:adverse effects; D015227:Lipid Peroxidation; D010264:Paraplegia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D011930:Reaction Time; D013119:Spinal Cord Injuries / Q000209:etiology / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology