title: Mammary excretion of cannabidiol in rabbits after intravenous administration.
abstract: The present study examined the distribution of cannabidiol into milk after an intravenous bolus injection (3 mg kg-1) to lactating rabbits. Drug concentrations in milk and serum were measured by HPLC. Cannabidiol was excreted into milk rapidly and the drug levels in milk increased over a 4-24-h period following the maternal injection. The mean milk to serum concentration ratio was 25.9, indicating a significant accumulation of the drug in milk.
authors.affiliation: Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia 29208.
authors.forename: S D
authors.initials: SD
authors.lastname: Yoo
authors.forename: T K
authors.initials: TK
authors.lastname: Fincher
authors.forename: J W
authors.initials: JW
authors.lastname: Holladay
mesh_terms: D000818:Animals; D002185:Cannabidiol / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007275:Injections, Intravenous; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008892:Milk / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits
chemical_list: D002185:Cannabidiol