title: Malignant aneuploid spindle-cell transformation in a proliferating trichilemmal tumour.
abstract: A case of spindle-cell carcinoma developed on a proliferating trichilemmal tumour (PTT) is presented. The tumour on the scalp of an 84-year-old white woman was excised and histological examination showed typical features of PTT, but with a coexistent malignant spindle-cell tumour with a sarcomatoid appearance. There were some areas of transition between squamous trichilemmal epithelium and the neoplastic mass composed of atypical spindle-shaped cells. Two years later, the patient was well, and neither recurrence nor metastases were observed. We report the second case of PTT with a malignant spindle-cell transformation with a sarcomatoid appearance (spindle-cell carcinoma), and a proven aneuploidy, demonstrated with DNA-flow cytometric analysis.
authors.affiliation: Department of Pathology, University Hospital Marqués de Valdecilla, Santander, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Alvarez-Quiñones
authors.forename: M F
authors.initials: MF
authors.lastname: Garijo
authors.forename: F
authors.initials: F
authors.lastname: Fernández
authors.forename: J F
authors.initials: JF
authors.lastname: Val-Bernal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D004814:Epidermal Cyst / Q000473:pathology*; D005260:Female; D006801:Humans; D012535:Scalp; D012536:Scalp Dermatoses / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*