Large somatostatin-insensitive thyrotrophin-secreting pituitary tumour responsive to D-thyroxine and dopamine agonists.
A unique thyrotrophin (TSH)-secreting pituitary tumour is described in a patient with a history of recurrent thyrotoxicosis. Unlike other previously reported TSHomas, the tumour is insensitive to octreotide, a somatostatin analogue. It does not accumulate [111In]octreotide but expresses functional dopamine receptors and responds to the D-isomer of thyroxine, two characteristics beneficial in the management of the patient.
Karlsson
F A
FA
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Burman
P
P
Kämpe
O
O
Westlin
J E
JE
Wide
L
L
D001971:Bromocriptine / Q000627:therapeutic use; D003918:Dextrothyroxine / Q000627:therapeutic use*; D015259:Dopamine Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D013971:Thyrotoxicosis / Q000150:complications; D013972:Thyrotropin / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
D015259:Dopamine Agents; D001971:Bromocriptine; D003918:Dextrothyroxine; D013972:Thyrotropin; D015282:Octreotide