Anti-idiotypes and their application under autoimmune, neoplastic, and infectious conditions.
Idiotypes and anti-idiotypes are becoming widely used in various experimental applications in multiple fields of research. Administration of anti-idiotypes has been attempted in order to manipulate immune reactions affecting autoimmune, neoplastic, and infectious processes. Immunization with anti-idiotypes and idiotypes may change the autoantibody expression in autoimmune diseases. In certain experimental models administration of anti-idiotypes and idiotypes may even propagate the induction of autoimmune-like disorders. Internal image bearing anti-idiotypes may provide an effective tool in the combat of neoplastic and infectious diseases. Such anti-idiotypes may resemble the structure of neoplastic cell antigen or mimic the composition of a contagious viral antigen. This review will deal in detail with the various aspects of idiotype and anti-idiotype immunomanipulation.
Shoenfeld
Y
Y
Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
Amital
H
H
Ferrone
S
S
Kennedy
R C
RC
D016915:AIDS Vaccines / Q000276:immunology; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000628:therapy*; D001428:Bacterial Vaccines / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D016052:Protozoan Vaccines / Q000276:immunology; D012550:Schistosoma mansoni / Q000276:immunology; D014612:Vaccines / Q000276:immunology*
D016915:AIDS Vaccines; D000888:Antibodies, Anti-Idiotypic; D001428:Bacterial Vaccines; D017325:Hepatitis B Vaccines; D016052:Protozoan Vaccines; D014612:Vaccines