title: Antideficit properties of neuroleptics.
abstract: The antidelusion effect, in the antiproductive sense of the term, represents the essential property of neuroleptics in research and publications in the United States. In France and in other European countries, however, a particular effect was observed early on that received various labels: disinhibitor, stimulant, antiautistic and anti-deficit, and that involved the beneficial action of certain neuroleptics on the negative symptoms of schizophrenia. The first period, ranging from 1952 to 1976, was characterized by a number of clinical observations and attempts at classification. In the second period, 1976 to 1984, much work was done in pharmacology and biochemistry. In the third period, 1984 to 1989, double-blind studies confirmed, among others, the disinhibiting effect, first of low doses of sulpiride and then of amisulpiride.
authors.affiliation: Department of Psychiatry, Rouen School of Medicine, France.
authors.forename: L
authors.initials: L
authors.lastname: Colonna
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003702:Delusions / Q000188:drug therapy / Q000523:psychology; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D006212:Hallucinations / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents