beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide.
Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid beta-amyloid peptide (beta 1-40) interacts with the cyclic oligosaccharide beta-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of beta 1-40 in a cell line.
Camilleri
P
P
Departments of Analytical Science, SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, Herts, UK.
Haskins
N J
NJ
Howlett
D R
DR
D000595:Amino Acid Sequence; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D003505:Cyclodextrins / Q000378:metabolism*; D013058:Mass Spectrometry / Q000379:methods; D008969:Molecular Sequence Data; D009420:Nervous System / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D047392:beta-Cyclodextrins
D016564:Amyloid beta-Protein Precursor; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; C031215:betadex