title: Topical gentamicin vestibular toxicity.
abstract: Two patients with large tympanic membrane perforations received Garasone eardrops. They developed severe acute vestibular deafferentation. In one patient, the middle ear mucosa was healthy and uninfected, and in the other ear, it was inflamed. It is recommended that caution be used in administration of Garasone to the middle ear. If damage can occur with gentamicin, it likely occurs with other ototoxic agents. It is recommended that ototoxic agents not be used in uninflamed middle ears during surgery. The patient should be instructed to treat the discharge through a perforation or tube for only 2 days after the discharge from the external canal ceases.
authors.affiliation: Division of Otolaryngology, University of British Columbia, Faculty of Medicine, Vancouver General Hospital.
authors.forename: N S
authors.initials: NS
authors.lastname: Longridge
mesh_terms: D000287:Administration, Topical; D005839:Gentamicins / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018058:Tympanic Membrane Perforation / Q000188:drug therapy*; D015837:Vestibular Diseases / Q000209:etiology
chemical_list: D005839:Gentamicins