title: Functional alterations of the microflora in patients with ulcerative colitis.
abstract: The aim of the study was to examine microflora-associated characteristics in patients with inactive ulcerative colitis, receiving sulphasalazine, in relation to the spread of the disease. The conversion of cholesterol to coprostanol, the production of urobilinogen, and the degradation of tryptic activity (FTA) and beta-aspartylglycine were measured in faecal samples from patients with proctitis or left-sided or total ulcerative colitis and in age- and sex-matched controls. No significant differences in the results were observed in patients with various degrees of extension of inflammatory bowel disease. However, the coprostanol ratio and the urobilinogen level were lower and the FTA was higher in patients with colitis than in the controls (p < 0.05). Beta-aspartylglycine was not found in any faecal sample. The results indicate that patients with ulcerative colitis taking sulphasalazine have a microflora with abnormal metabolic characteristics.
authors.affiliation: Dept. of Medicine, Danderyd Hospital, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Benno
authors.forename: C E
authors.initials: CE
authors.lastname: Leijonmarck
authors.forename: U
authors.initials: U
authors.lastname: Monsén
authors.forename: A
authors.initials: A
authors.lastname: Uribe
authors.forename: T
authors.initials: T
authors.lastname: Midtvedt
mesh_terms: D000328:Adult; D004083:Cholestanol / Q000032:analysis; D002784:Cholesterol / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000382:microbiology*; D004151:Dipeptides / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011349:Proctitis / Q000382:microbiology; D012460:Sulfasalazine / Q000627:therapeutic use; D014357:Trypsin / Q000378:metabolism; D014558:Urobilinogen / Q000096:biosynthesis
chemical_list: D004151:Dipeptides; D014558:Urobilinogen; C017033:aspartylglycine; D012460:Sulfasalazine; D004083:Cholestanol; D002784:Cholesterol; D014357:Trypsin