title: Parabrachial nucleus lesions impair feeding response elicited by 2,5-anhydro-D-mannitol.
abstract: Systemic injection of the fructose analogue 2,5-anhydro-D-mannitol (2,5-AM) elicits a feeding response and induces c-fos activity in the parabrachial nuclei (PBN). We used bilateral ibotenic acid lesions of PBN to determine whether the activation inferred from c-fos activity was causally related to the feeding response. The relationship between the PBN lesion and feeding behavior was also examined with the glucose analogue 2-deoxy-D-glucose (2-DG). The PBN lesions interfered with the feeding response to 2,5-AM but spared the feeding response to 2-DG. Rats were also tested in a conditioned taste-aversion paradigm. Differences were observed in the relationship between lesion extent and behavioral deficit for feeding responses to 2,5-AM and taste-guided intake after taste-aversion conditioning. These data provide the first demonstration that central lesions can disrupt feeding responses to peripherally acting 2,5-AM. The results suggest that the neural substrate for this response differs from that mediating taste-aversion conditioning and from that involved in the feeding response to 2-DG.
authors.affiliation: Graduate Group of Psychology, University of Pennsylvania, Philadelphia 19104.
authors.forename: H J
authors.initials: HJ
authors.lastname: Grill
authors.forename: M I
authors.initials: MI
authors.lastname: Friedman
authors.forename: R
authors.initials: R
authors.lastname: Norgren
authors.forename: G
authors.initials: G
authors.lastname: Scalera
authors.forename: R
authors.initials: R
authors.lastname: Seeley
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D003847:Deoxyglucose / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology*; D016762:Genes, fos / Q000235:genetics; D007051:Ibotenic Acid / Q000633:toxicity; D008297:Male; D008353:Mannitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011149:Pons / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000963:Antimetabolites; D007051:Ibotenic Acid; D008353:Mannitol; C031765:2,5-anhydromannitol; D003847:Deoxyglucose