Small virus-like structure in fractions from scrapie hamster brain.
The scrapie model in hamsters has been used to search for the agents that cause Creutzfeldt-Jakob disease in man and similar transmissible encephalopathies in animals. We found structures that are extraordinarily small for a virus, but exhibit viral structural properties in negatively stained samples, by electron microscopy in fractions containing scrapie-associated fibrils.
Ozel
M
M
Robert Koch-Institut des Bundesgesundheltsamtes, Berlin, FGR.
Diringer
H
H
D000818:Animals; D001921:Brain / Q000382:microbiology* / Q000648:ultrastructure; D006224:Cricetinae; D004195:Disease Models, Animal; D008854:Microscopy, Electron; D017096:Prion Diseases / Q000382:microbiology / Q000473:pathology; D012608:Scrapie / Q000382:microbiology* / Q000473:pathology