Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women.
Oxidative modification of low-density lipoprotein (LDL) may be atherogenic. We studied the time of onset of LDL oxidation (lag) in 18 postmenopausal women before and after intraarterial infusion of 17 beta-oestradiol, after 3 weeks' patch administration in 12 of these women, and 1 month after discontinuation in 10. The lag increased from baseline after acute infusion (from 134 [SD41] to 167 [36] min, p = 0.01) and after the patch (132 [31] to 178 [45] min, p = 0.009). After discontinuation of oestradiol, the lag returned to baseline. This study shows an antioxidant effect of physiological levels of 17 beta-oestradiol, which may contribute to an anti-atherogenic action.
Sack
M N
MN
Georgetown University Hospital, Washington, DC.
Rader
D J
DJ
Cannon
R O
RO
D000279:Administration, Cutaneous; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects*; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood / Q000187:drug effects*; D013997:Time Factors
D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D004958:Estradiol; D002784:Cholesterol