Effect of retinoic acid on HL-60 cells infected with human immunodeficiency virus type 1.
HL-60 cells infected with human immunodeficiency virus type 1 (HIV 1) can be induced to differentiate along the granulocyte pathway by retinoic acid. In these cells, HIV mRNA synthesis is stimulated, but synthesis of viral proteins and virus replication are blocked and HIV-infected cells die after becoming apoptotic and/or vacuolized.
Semmel
M
M
Unité 268 INSERM, Villejui, France.
Macho
A
A
Coulaud
D
D
Alileche
A
A
Plaisance
S
S
Aguilar
J
J
Jasmin
C
C
D017209:Apoptosis; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006098:Granulocytes / Q000473:pathology / Q000821:virology*; D015497:HIV-1 / Q000254:growth & development*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D008854:Microscopy, Electron; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014617:Vacuoles / Q000473:pathology; D014779:Virus Replication / Q000187:drug effects
D012333:RNA, Messenger; D012367:RNA, Viral; D014212:Tretinoin