Basal ganglia pathology in schizophrenia and tardive dyskinesia: an MRI quantitative study.
Magnetic resonance imaging was used to measure the volumes of the caudate, putamen, and globus pallidus of 25 schizophrenic patients (17 men and eight women) and 26 age- and sex-matched comparison subjects (18 men and eight women). Schizophrenic patients had significantly larger right and left globus pallidus and right putamen volumes than comparison subjects. There were no significant differences between schizophrenic patients with and without persistent tardive dyskinesia in the volume of any of the three structures.
Elkashef
A M
AM
NIMH Neuroscience Center, St. Elizabeths Hospital, Washington, D.C. 20032.
Buchanan
R W
RW
Gellad
F
F
Munson
R C
RC
Breier
A
A
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000473:pathology*; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000473:pathology; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D005917:Globus Pallidus / Q000033:anatomy & histology / Q000473:pathology; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
D014150:Antipsychotic Agents