title: Postpartum course in women with preexisting panic disorder.
abstract: BACKGROUND
  The postpartum period has typically been considered a time of risk for development of psychiatric disorder. Impact of the postpartum period on the course of anxiety disorders has not been characterized. This report describes the postpartum clinical course of 40 nondepressed women with preexisting panic disorder who were followed during pregnancy and the puerperium.
  
  
  METHODS
  Through chart review and interview, we retrospectively evaluated the clinical course during the postpartum period of 40 women with pregravid panic disorder. Severity of illness, along with treatment received, was assessed from the third trimester of pregnancy to the twelfth postpartum week.
  
  
  RESULTS
  While 26 patients (65%) either maintained (N = 23) or improved (N = 3) clinical status, 14 patients (35%) demonstrated puerperal worsening. Those patients who received pharmacotherapy by Trimester 3 were significantly less likely to experience puerperal worsening of anxiety than those who did not receive treatment prior to the puerperium (p < .0001).
  
  
  CONCLUSIONS
  The puerperium is a period of risk for some women with pregravid panic disorder. Antipanic medication may be prophylactic for those women at greatest risk.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston 02114.
authors.forename: L S
authors.initials: LS
authors.lastname: Cohen
authors.forename: D A
authors.initials: DA
authors.lastname: Sichel
authors.forename: J A
authors.initials: JA
authors.lastname: Dimmock
authors.forename: J F
authors.initials: JF
authors.lastname: Rosenbaum
mesh_terms: D000553:Ambulatory Care; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016584:Panic Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011569:Psychiatric Status Rating Scales; D011644:Puerperal Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents