[Changes in cellular proliferative activity after exposure to irradiation at low doses].
Cell proliferation, colony size, and the level of DNA damage in HeLa cells subjected to acute gamma-radiation (60Co, 75 cGy/min) in a dose of 10-40 cGy and in the descendant generations were studied. Radiation was found to reduce proliferative activity in cell generations distant from irradiation, to cause a reduction in the number of cells in colonies, and to induce DNA damages which could be revealed by the treatment of cells with a mixture of the reparative and replicative DNA synthesis inhibitors arabinosylcytosine (araC) and hydroxyurea (HU). The effect value and duration increased with the increase in radiation dose.
Al'ferovich
A A
AA
Gotlib
V Ia
VIa
Pelevina
I I
II
D002452:Cell Count / Q000187:drug effects / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006367:HeLa Cells / Q000528:radiation effects*; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology
D003561:Cytarabine; D004247:DNA; D006918:Hydroxyurea
Izmenenie proliferativnoĭ aktivnosti kletok posle vozdeĭstviia oblucheniia v malykh dozakh.