Induction of a 60-kDa heat shock protein in rat pancreas by water-immersion stress.
1. In this study, expression of a 60-kDa heat shock protein in rat pancreas was investigated before and after water-immersion stress, which has been known as an exacerbation factor of caerulein-induced pancreatitis in rats, by Western blot. 2. A 60-kDa heat shock protein increased after water-immersion stress in both soluble and insoluble fractions of the pancreas. 3. Serum amylase level and pancreas weight did not increase after water-immersion. 4. No pathologic alteration was observed in the pancreas after water-immersion.
Otaka
M
M
First Department of Internal Medicine, Akita University School of Medicine, Japan.
Itoh
H
H
Kuwabara
T
T
Zeniya
A
A
Fujimori
S
S
Tashima
Y
Y
Masamune
O
O
D000818:Animals; D002108:Ceruletide; D018834:Chaperonin 60; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D007101:Immersion; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010195:Pancreatitis / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000378:metabolism*; D014867:Water
D018834:Chaperonin 60; D006360:Heat-Shock Proteins; D014867:Water; D002108:Ceruletide