Macromolecular crowding and molecular recognition.
The effects of macromolecular crowding upon macromolecular associations in solution, and upon binding of a macromolecular ligand to a surface site, are reviewed. It is demonstrated, by means of two examples, that crowding may lead to significant alterations of biochemical or biological recognition processes at the molecular level.
Minton
A P
AP
Section on Physical Biochemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
D001665:Binding Sites; D001667:Binding, Competitive; D066298:In Vitro Techniques; D008024:Ligands; D046911:Macromolecular Substances; D008954:Models, Biological; D008956:Models, Chemical; D011991:Receptors, Virus / Q000502:physiology; D012996:Solutions; D013816:Thermodynamics
D008024:Ligands; D046911:Macromolecular Substances; D011991:Receptors, Virus; D012996:Solutions