Polygenic expression of somatostatin in lamprey.
Previous studies have led to the identification of three biosynthetically related molecular forms of somatostatin (somatostatin-14, -34 and -37) from the pancreas of the sea lamprey (Petromyzon marinus). We have now isolated from the brain of the same species a second form of somatostatin-14 that is identical to mammalian somatostatin-14 and differs from lamprey pancreatic somatostatin-14 by the substitution Ser12 to Thr. Larger forms of somatostatin were not identified in lamprey brain in this study. These data suggest that the two molecular forms of lamprey somatostatin-14 are the products of different genes that are expressed in a tissue-specific manner.
Sower
S A
SA
Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham 03824.
Chiang
Y C
YC
Conlon
J M
JM
D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D007798:Lampreys / Q000378:metabolism*; D008297:Male; D008969:Molecular Sequence Data; D013004:Somatostatin / Q000235:genetics*
D013004:Somatostatin