Spatial organization of ABR and CRK genes on human chromosome band 17p13.3.
Deletion of part or all of chromosome 17p is among the most frequent chromosome abnormalities in human cancer. We show that the CRK and ABR genes are close to a marker on chromosome 17p13.3, D17S34, which is frequently deleted in different tumours, and demonstrate that CRK is centromeric to ABR. CRK and ABR may be involved in cancer themselves, or otherwise may function as points of reference for further experiments to clone genes from chromosome 17p which may play a role in cancer.
Morris
C
C
Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.
Benjes
S
S
Haataja
L
L
Ledbetter
D H
DH
Heisterkamp
N
N
Groffen
J
J
D002871:Chromosome Banding; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D020690:GTPase-Activating Proteins; D006801:Humans; D011506:Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D050737:Proto-Oncogene Proteins c-crk
C082659:ABR protein, human; D020690:GTPase-Activating Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D050737:Proto-Oncogene Proteins c-crk