Endothelin-1 mRNA expression by peripheral blood monocytes in IgA nephropathy.
We investigated endothelin-1 mRNA expression in peripheral blood monocytes from 40 patients with IgA nephropathy, 40 with other glomerulonephritides and 10 with essential hypertension without renal diseases, and from 30 healthy age-matched controls. 95% of patients with IgA nephropathy had increased endothelin-1 mRNA expression in monocytes but little was detected from the other groups. Endothelin-1 mRNA was positively correlated with urinary protein excretion (95% CI 0.835-0.952) and histopathological findings (0.796-0.939). In 15 patients with IgA nephropathy endothelin-1 mRNA values and proteinuria decreased gradually after treatment. Endothelin-1 mRNA-expressing activated monocytes may be associated with the progression of IgA nephropathy.
Nakamura
T
T
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Ebihara
I
I
Shirato
I
I
Fukui
M
M
Tomino
Y
Y
Koide
H
H
D000293:Adolescent; D000328:Adult; D016232:Endothelins / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism*
D016232:Endothelins; D012333:RNA, Messenger