Bradykinin antagonists: development and applications.
Bradykinin (BK) is involved in regulation of every major physiological system and is an initiator or mediator of many pathophysiological conditions. Rapid progress in understanding these aspects of BK biology has come since the discovery of BK antagonists. This article reviews principal points in the history of the kallikrein-kinin field and of kinin biology. The chemistry and development of antagonists for B1 and B2 kinin receptors is discussed. Uses of the antagonists in biomedical research and potential clinical applications are presented.
Stewart
J M
JM
Department of Biochemistry, University of Colorado Medical School, Denver 80262.
D000595:Amino Acid Sequence; D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007610:Kallikreins / Q000502:physiology; D007705:Kinins / Q000737:chemistry* / Q000502:physiology*; D008322:Mammals; D008969:Molecular Sequence Data; D015290:Second Messenger Systems
D007705:Kinins; D007610:Kallikreins; D001920:Bradykinin