title: Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T.
abstract: Brain glutamate and glutamine were detected in healthy human volunteers in spectroscopic images with a nominal voxel size of 2.25 cm3 at an echo time of 15 ms. Due to the increased frequency separation and simplification of J-coupling patterns, the separate detection of brain glutamate and glutamine at short echo times was possible. Creatine, choline, and N-acetylaspartate with other N-acetylated compounds were also detected. The ratios of the metabolite resonance intensities were in agreement with previously published values.
authors.affiliation: Department of Medicine, University of Alabama at Birmingham 35294.
authors.forename: G F
authors.initials: GF
authors.lastname: Mason
authors.forename: J W
authors.initials: JW
authors.lastname: Pan
authors.forename: S L
authors.initials: SL
authors.lastname: Ponder
authors.forename: D B
authors.initials: DB
authors.lastname: Twieg
authors.forename: G M
authors.initials: GM
authors.lastname: Pohost
authors.forename: H P
authors.initials: HP
authors.lastname: Hetherington
mesh_terms: D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D005971:Glutamates / Q000032:analysis*; D018698:Glutamic Acid; D005973:Glutamine / Q000032:analysis*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D018377:Neurotransmitter Agents / Q000032:analysis*; D012815:Signal Processing, Computer-Assisted
chemical_list: D005971:Glutamates; D018377:Neurotransmitter Agents; D005973:Glutamine; D018698:Glutamic Acid