[Congenital toxoplasmosis: transmission to the fetus of a pre-pregnancy maternal infection].
It has been established that maternal immunity developing before conception protects the fetus from congenital toxoplasmosis. We observed a case of congenital toxoplasmosis consecutive to a maternal toxoplasma infection that had preceded pregnancy. A woman with normal immune system developed toxoplasmosis 2 months before conceiving. No treatment was given to this prepregnancy seroconverted patient. At 25 weeks of amenorrhoea, the ultrasound examination showed a fetal cerebral ventricular dilatation. Amniocentesis and cordocentesis showed fetal toxoplasmosis infection. Fetopathologic examination confirmed the diagnosis of cerebral toxoplasmosis. The pathophysiology of maternal-fetal toxoplasma transmission and the role played by maternal immunodeficiency are discussed. This exceptional case-report showed the difficulties of the management in patients with 3-month pre-pregnancy toxoplasmosis and its practical implications.
Pons
J C
JC
Service de Gynécologie-Obstétrique 1, Hôpital Cochin-Port Royal, Paris.
Sigrand
C
C
Grangeot-Keros
L
L
Frydman
R
R
Thulliez
P
P
D000032:Abortion, Therapeutic; D000208:Acute Disease; D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000469:parasitology*; D006801:Humans; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic; D011296:Prenatal Diagnosis; D013997:Time Factors; D014123:Toxoplasmosis / Q000635:transmission*; D014125:Toxoplasmosis, Congenital / Q000209:etiology*
Toxoplasmose congénitale: transmission au foetus d'une infection maternelle antéconceptionnelle.