Rolipram inhibits airway microvascular leakage induced by platelet-activating factor, histamine and bradykinin in guinea-pigs.
Rolipram (0.1-1000 micrograms kg-1, i.v.) reduced the increase in microvascular permeability induced by platelet-activating factor (PAF; 50 ng kg-1, i.v.) at different sites of the guinea-pig airways. Rolipram (1-100 micrograms kg-1, i.v.) inhibited histamine (30 micrograms kg-1, i.v.)- and bradykinin (0.3 micrograms kg-1, i.v.)-induced airway microvascular leakage. These effects of rolipram were obtained at doses which inhibit histamine (7-20 micrograms kg-1 min-1)-induced bronchoconstriction (IC50 = 3 +/- 1 micrograms kg-1, i.v.) without depressing arterial blood pressure in the guinea-pig. Aminophylline (50 mg kg-1) did not change the effect of PAF. The anti-exudative effect of rolipram is of potential therapeutic value in asthma.
Ortiz
J L
JL
Department of Pharmacology, University of Valencia, Spain.
Cortijo
J
J
Vallés
J M
JM
Bou
J
J
Morcillo
E J
EJ
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology*; D001980:Bronchi / Q000098:blood supply*; D002199:Capillary Permeability / Q000187:drug effects*; D004347:Drug Interactions; D005070:Evans Blue / Q000493:pharmacokinetics; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D008833:Microcirculation / Q000502:physiology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D020889:Rolipram; D014132:Trachea / Q000098:blood supply*
D010726:Phosphodiesterase Inhibitors; D010972:Platelet Activating Factor; D011760:Pyrrolidinones; D000628:Aminophylline; D005070:Evans Blue; D006632:Histamine; D020889:Rolipram; D001920:Bradykinin