Experimental cryptorchidism in prepubertal rats: some effects on reactivity of the seminal vesicle to catecholamines.
The development of testes and genital accessory organs, the plasma testosterone concentration and the reactivity of seminal vesicles to catecholamines were studied in rats rendered cryptorchid at the time of prepubertal growth. The wet weights of the accessory organs and the testosterone concentrations were reduced and corresponded to those observed after castration. The response of the seminal vesicle to adrenaline and noradrenaline, but not to methoxamine, showed a reduction in sensitivity. It is suggested that an enhancement of neuronal catecholamine uptake may have occurred. The results also reinforce the idea that development, plasma testosterone concentration and reactivity of seminal vesicles are independent phenomena. In cryptorchidism, despite the consequences arising from the maintenance of the testes at body temperature rather than at the lower temperature of the scrotum, the age that the rat is rendered cryptorchid is also of fundamental importance.
Pereira
O C
OC
Departamento de Farmacologia, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Picarelli
Z P
ZP
Abreu
L C
LC
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology*; D003456:Cryptorchidism / Q000097:blood / Q000503:physiopathology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000187:drug effects* / Q000473:pathology; D012741:Sexual Maturation / Q000502:physiology*; D013739:Testosterone / Q000097:blood*
D002395:Catecholamines; D013739:Testosterone