title: 1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates.
abstract: Twenty eight schizophrenic patients and 20 normal volunteers underwent proton magnetic resonance spectroscopy (MRS) on the left temporal and frontal lobe regions. Male patients showed a significant reduction in frontal but not temporal n-acetylaspartate (an intraneuronally distributed metabolite) in comparison with either male controls or female patients; frontal choline was raised in male patients relative to these groups. Putative neurodevelopmental indices, including obstetric complications, family history of schizophrenia, and minor physical anomalies, proved unrelated to MRS resonances. However, multiple aspects of memory function in patients were related to temporal but not frontal creatine, a pattern that was not apparent among controls. These MRS findings complement some previous structural MRI studies and much clinical and epidemiological evidence of important gender differences in schizophrenia. The findings also suggest that memory dysfunction in patients with schizophrenia may be associated with a particular pattern of temporal lobe metabolism on MRS.
authors.affiliation: St. John of God Psychiatric Service Stillorgan, Co. Dublin.
authors.forename: P F
authors.initials: PF
authors.lastname: Buckley
authors.forename: C
authors.initials: C
authors.lastname: Moore
authors.forename: H
authors.initials: H
authors.lastname: Long
authors.forename: C
authors.initials: C
authors.lastname: Larkin
authors.forename: P
authors.initials: P
authors.lastname: Thompson
authors.forename: F
authors.initials: F
authors.lastname: Mulvany
authors.forename: O
authors.initials: O
authors.lastname: Redmond
authors.forename: J P
authors.initials: JP
authors.lastname: Stack
authors.forename: J T
authors.initials: JT
authors.lastname: Ennis
authors.forename: J L
authors.initials: JL
authors.lastname: Waddington
mesh_terms: D000328:Adult; D002794:Choline / Q000032:analysis / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology; D003401:Creatine / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008569:Memory Disorders / Q000378:metabolism; D011859:Radiography; D012559:Schizophrenia / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D012737:Sex Factors; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D003401:Creatine; D002794:Choline