title: Vasoconstrictors during pregnancy--in vitro trial on pregnant and nonpregnant mouse uterus.
abstract: In an in vitro trial on 80 pregnant and nonpregnant mice, the sensitivity of the uterus myometrium to the vasoconstrictors vasopressin, ornipressin, epinephrine, and norepinephrine was examined in comparison with oxytocin as a standardized stimulative drug. The pregnant uterus showed a significantly increased sensitivity to ornipressin, vasopressin, and norepinephrine. Epinephrine showed no uterus-stimulating effect, and an increase of sensitivity caused by pregnancy was not detected.
authors.affiliation: Klinik für Kiefer-Gesichts-Chirurgie, Eberhard-Karls-Universität Tübingen, Germany.
authors.forename: M T
authors.initials: MT
authors.lastname: Stepke
authors.forename: N
authors.initials: N
authors.lastname: Schwenzer
authors.forename: W
authors.initials: W
authors.lastname: Eichhorn
mesh_terms: D000818:Animals; D004361:Drug Tolerance; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D051379:Mice; D009215:Myometrium / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D009951:Ornipressin / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014667:Vasopressins / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014667:Vasopressins; D009951:Ornipressin; D009638:Norepinephrine; D004837:Epinephrine