Evidence that transglutaminase and synapsin I are involved in the neuroparalytic action of tetanus toxin.
Facchiano
F
F
Laboratory of Molecular Neurobiology, Istituto di Ricerche Farmacologische Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro (Chieti), Italy.
Di Tullio
M
M
Luini
A
A
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004789:Enzyme Activation; D006160:Guanosine Triphosphate / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D009498:Neurotoxins / Q000494:pharmacology / Q000633:toxicity*; D016548:Prosencephalon / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D016704:Synapsins / Q000378:metabolism*; D013572:Synaptic Vesicles / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D013744:Tetanus Toxin / Q000494:pharmacology / Q000633:toxicity*; D011503:Transglutaminases / Q000378:metabolism*
D009498:Neurotoxins; D016704:Synapsins; D013744:Tetanus Toxin; D006160:Guanosine Triphosphate; D011503:Transglutaminases; D002118:Calcium; D013095:Spermidine; D011700:Putrescine