[RFLP-PCR technique for exclusion of carrier status of the mutated Rb gene].
Molecular-genetic analysis of DNA by PCR-RFLP technique in a family with a case of unilateral retinoblastoma was performed. The carrier status of mutated Rb gene in a sister of proband was excluded on the basis of molecular analysis despite unsynonymous pedigree data.
Zajaczek
S
S
Zakładu Genetyki i Patomorfologii Instytutu Patologii, Pomorskiej AM.
Podolski
J
J
Lubiński
J
J
Rosławska
A
A
Krzystolik
Z
Z
Sagan
Z
Z
D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis*; D005190:Family; D005260:Female; D016161:Genes, Retinoblastoma / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D009154:Mutation; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012175:Retinoblastoma / Q000235:genetics*
D004273:DNA, Neoplasm
Technika RFLP-PCR w wykluczeniu nosicielstwa zmutowanego genu Rb.