HIV-1 infection of monocyte-derived macrophages reduces Fc and complement receptor expression.
Fc receptor (FcR) and complement receptor (CR) expression on HIV-infected monocyte-derived macrophages may be an important determinant of immune function. We studied the effects of HIV-1 infection of macrophages in vitro on FcR and CR expression. Macrophages were infected with HIV-1DV 7 days following isolation, and the expression of Fc gamma RI-III and CR3 were measured at intervals thereafter by flow cytometry. We found a reduction in receptor expression with the percentage of cells expressing FcRI 14 days post infection declining from 77% to 13%, FcRII fell from 96% to 85%, FcRIII from 45% to 9%, and CR3 from 91% to 67% 14 days following infection. As these receptors are important for macrophage function, their down-modulation may contribute to the pathogenesis of HIV-related disease.
Kent
S J
SJ
AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Australia.
Stent
G
G
Sonza
S
S
Hunter
S D
SD
Crowe
S M
SM
D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D015497:HIV-1 / Q000254:growth & development*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D016177:Macrophage-1 Antigen / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology; D011961:Receptors, Fc / Q000096:biosynthesis*
D015815:Cell Adhesion Molecules; D016177:Macrophage-1 Antigen; D011961:Receptors, Fc; D018799:Intercellular Adhesion Molecule-1