IgA nephropathy and idiopathic thrombocytopenic purpura with splenectomy: a case report.
A 14-year-old boy who had had a splenectomy at the age of 2 years for idiopathic thrombocytopenic purpura, suffered from IgA nephropathy. Serum IgA and IgE levels were elevated and low levels of circulating immune complexes were detected. Splenectomy may play a role in the pathogenesis or susceptibility to IgA nephropathy by means of decreased clearance of circulating immune complexes or impaired immune regulation, such as increased IgA synthesis.
Morino
M
M
Department of Paediatrics, Saitama Medical School, Japan.
Inami
K
K
Shibuya
A
A
Sasaki
N
N
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000032:analysis; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000601:surgery*; D013156:Splenectomy / Q000009:adverse effects
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007073:Immunoglobulin E