title: Effects of target identity and collision energy on the fragmentation of some mass-selected protonated neuropeptides.
abstract: A number of protonated neuropetides formed by 10 keV Cs+ ion bombardment are mass selected and their collision-induced dissociations (CID) with helium, argon, xenon and isobutane are monitored using a collision energy of 200 eV. Data obtained by fixing the collision gas and using translational energies in the range 50-250 eV are also presented. The present data imply that optimization of the CID spectra presented can be achieved through a judicious choice of both the target gas and the translational energy of the mass-selected ion. The combined effect of the two experimental parameters on the relative abundances of the major sequence ions and on the loss of side-chain moieties is discussed.
authors.affiliation: Glaxo Research Laboratories, Verona, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Curcuruto
authors.forename: M
authors.initials: M
authors.lastname: Hamdan
mesh_terms: D001128:Argon; D002073:Butanes; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives; D006371:Helium; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D009842:Oligopeptides; D011522:Protons; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014978:Xenon
chemical_list: D002073:Butanes; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D009842:Oligopeptides; D011522:Protons; D006371:Helium; D014978:Xenon; C011536:proctolin; D004743:Enkephalin, Leucine; C048614:enkephalinamide-Leu; D001128:Argon