title: Chlorpromazine in combination with nitrosourea inhibits experimental glioma growth.
abstract: Modern cancer therapy has improved the prognosis for several tumour types. This, however, does not apply to the largest group of brain tumours, the malignant astrocytomas grades III-IV. Hence, there is need for new ideas to improve treatment. Ca2+ and the Ca(2+)-binding protein calmodulin have been shown to be involved in the processes conferring stability to DNA in proliferating neoplastic cells. We have combined the calmodulin-inhibiting neuroleptic drug chlorpromazine (CPZ), with the anti-neoplastic drug 1,3-bis(2-chloroethyl-1)-nitrosourea (BCNU) in a treatment regime for rats with glioma cells implanted in the brain. A highly significant inhibiting effect upon the tumour growth was noticed, not by CPZ or BCNU as single drugs, but with their combination.
authors.affiliation: Department of Neurosurgery, Lund University Hospital, Sweden.
authors.forename: A T
authors.initials: AT
authors.lastname: Aas
authors.forename: A
authors.initials: A
authors.lastname: Brun
authors.forename: R W
authors.initials: RW
authors.lastname: Pero
authors.forename: L G
authors.initials: LG
authors.lastname: Salford
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001932:Brain Neoplasms / Q000473:pathology*; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000502:physiology; D002330:Carmustine / Q000494:pharmacology* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects* / Q000502:physiology; D002746:Chlorpromazine / Q000494:pharmacology* / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D005909:Glioblastoma / Q000473:pathology*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002147:Calmodulin; D002746:Chlorpromazine; D002330:Carmustine