On interleukins 4, 6 and 10 and their interrelationship with immunoglobulins G and M in common variable immunodeficiency.
Following culture of human peripheral blood mononuclear cells (PBMNC) from 25 normal donors and 15 patients with common variable immunodeficiency (CVID), we were unable to identify any IL10-defective patients. Clear-cut effects of IL4 could be demonstrated in controls, while in CVID all effects are less pronounced. While in both controls and CVID baseline levels of IL6, IgG and IgM were found to be correlated, this was altered by the addition of either IL4 or Poke Weed Mitogen (PWM). We therefore conclude that the inability of PBMNC to produce IL10 is not the cause of CVID in our patients. In CVID, the regulating circuitry triggered by IL4 remains principally intact, however, some subgroups of CVID behave significantly differently.
Fritsch
A
A
Institute of Clinical Immunology, F.-Schiller-University, Jena, Germany.
Junker
U
U
Vogelsang
H
H
Jager
L
L
D000328:Adult; D000368:Aged; D016175:B-Lymphocyte Subsets / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D017074:Common Variable Immunodeficiency / Q000097:blood* / Q000145:classification / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D008297:Male; D008875:Middle Aged; D011043:Pokeweed Mitogens / Q000494:pharmacology; D017464:Receptors, Complement 3d / Q000032:analysis; D011994:Recombinant Proteins / Q000494:pharmacology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015850:Interleukin-6; D011043:Pokeweed Mitogens; D017464:Receptors, Complement 3d; D011994:Recombinant Proteins; D016753:Interleukin-10; D015847:Interleukin-4