title: Holoprosencephaly in a long-tailed macaque (Macaca fascicularis): a case report.
abstract: A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.
authors.affiliation: California Regional Primate Research Center, University of California, Davis 95616-8542.
authors.forename: A F
authors.initials: AF
authors.lastname: Tarantal
authors.forename: G
authors.initials: G
authors.lastname: Otiang-a-Owiti
authors.forename: A G
authors.initials: AG
authors.lastname: Hendrickx
mesh_terms: D000034:Abortion, Veterinary; D000818:Animals; D005260:Female; D005865:Gestational Age; D006257:Head / Q000002:abnormalities*; D016142:Holoprosencephaly / Q000196:embryology / Q000662:veterinary*; D008252:Macaca fascicularis; D015735:Mifepristone / Q000633:toxicity; D009666:Nose / Q000002:abnormalities; D011247:Pregnancy; D018419:Primate Diseases; D013723:Teratogens / Q000633:toxicity; D016216:Ultrasonography, Prenatal / Q000662:veterinary
chemical_list: D013723:Teratogens; D015735:Mifepristone