Hyperaemia in rat neocortex produced by acute exposure to methylenedioxymethamphetamine.
Cerebral blood flow and glucose utilization were measured in rat neocortex, hippocampus and striatum following methylenedioxymethamphetamine injection (5 mg/kg, i.v.), using the tracers [14C]iodoantipyrine and [14C]2-deoxyglucose, respectively. In control rats, blood flow was coupled to glucose metabolism, but in methylenedioxymethamphetamine-treated rats, marked hyperperfusion was measured in frontal and parietal cortex with no change in glucose use. This suggests that methylenedioxymethamphetamine has the potential to disrupt cerebrovascular control.
Kelly
P A
PA
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK.
Ritchie
I M
IM
Sangra
M
M
Cursham
M J
MJ
Dickson
E M
EM
Kelly
B
B
Neilson
F P
FP
Reidy
M J
MJ
Stevens
M C
MC
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006940:Hyperemia / Q000139:chemically induced*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014018:Tissue Distribution
D005947:Glucose; D018817:N-Methyl-3,4-methylenedioxyamphetamine