Metabolism of phenothiazine and butyrophenone antipsychotic drugs. A review of some recent research findings and clinical implications.
Whereas some metabolites of antipsychotic drugs are psychoactive and contribute to clinical improvement, recent studies have provided evidence that certain metabolites contribute to side-effects which can be disabling enough to negate clinical improvement as regards the psychosis. The route of administration of the drug can determine the amount of metabolite produced in the body and affect how the patient feels in response to the treatment.
Hubbard
J W
JW
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
Midha
K K
KK
Hawes
E M
EM
McKay
G
G
Marder
S R
SR
Aravagiri
M
M
Korchinski
E D
ED
D000818:Animals; D014150:Antipsychotic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002746:Chlorpromazine / Q000493:pharmacokinetics; D005476:Fluphenazine / Q000493:pharmacokinetics; D006220:Haloperidol / Q000493:pharmacokinetics; D006801:Humans; D013881:Thioridazine / Q000493:pharmacokinetics
D014150:Antipsychotic Agents; D006220:Haloperidol; D013881:Thioridazine; D005476:Fluphenazine; D002746:Chlorpromazine