Diacylglycerol: formation and function in phospholipid-mediated signal transduction.
1. Properties, distribution and multiplicity of phosphoinositidases (phospholipase C, PLC) are investigated. 2. Generation of diacylglycerol (DAG) by a variety of enzymes such as phosphoinositide and phosphatidylcholine specific PLC, by a combination of phospholipase D and phosphatidic hydrolase, and by triglyceride lipase is examined. 3. Ca2+ and phospholipid-dependent protein kinase C act as the target of DAG messenger action. 4. There are differences in the formation of DAG in normal and transformal cell.
Haeffner
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FSP Diagnostik und Experimentelle Therapie, Deutsches Krebsforschungszentrum, Heidelberg, F.R.G.
D000818:Animals; D004075:Diglycerides / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology*; D010743:Phospholipids / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D004075:Diglycerides; D010743:Phospholipids