title: Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome.
abstract: A preparation of extracts from the root of the Chinese medicinal herb Tripterygium wilfordii Hook was administered orally at a dose of 1 mg/kg body weight per day to 13 children with idiopathic nephrotic syndrome. Eight children, including 4 who were steroid resistant, went into remission which was maintained in 4 for up to 3 years after withdrawal of treatment. In 3 children the proteinuria lessened with the return of plasma protein concentration to normal, and in 1 child this improvement was maintained for 4 years after treatment ceased. No serious side-effects were noted, but a temporary anti-fertility activity has been noted in other studies of both men and women.
authors.affiliation: Nanjing Medical University, Center of Pediatric Nephrology, People's Republic of China.
authors.forename: X
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000284:Administration, Oral; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D012008:Recurrence; D012074:Remission Induction
chemical_list: D004365:Drugs, Chinese Herbal