Which plasma factors bring about disturbance of endothelial function in pre-eclampsia?
The characteristic pathophysiological changes in pre-eclampsia are thought to be related to abnormalities of the maternal vascular endothelium. We suggest that the blood components that affect the risk of such damage are very-low-density lipoproteins (VLDL), which injure the endothelium, and toxicity-preventing activity (the pl 5.6 form of plasma albumin), which protects against VLDL-induced injury.
Arbogast
B W
BW
Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City.
Leeper
S C
SC
Merrick
R D
RD
Olive
K E
KE
Taylor
R N
RN
D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D008079:Lipoproteins, VLDL / Q000097:blood; D011225:Pre-Eclampsia / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D012709:Serum Albumin / Q000502:physiology
D008079:Lipoproteins, VLDL; D012709:Serum Albumin