title: Induction of long-lasting potentiation by sequenced applications of isoproterenol.
abstract: Norepinephrine is associated with long-lasting modifications of neuronal activation in hippocampal slices. Long-lasting potentiation is produced by a single application of 1.0 microM isoproterenol (a beta-adrenergic antagonist) to the dentate gyrus. The results of the present work indicate that a much lower 75 nM concentration of isoproterenol produces long-lasting potentiation in the dentate gyrus if it is perfused in two applications separated by a 30 min wash. The potentiation so produced is prevented by beta-adrenergic receptor antagonists, but not prevented by the NMDA receptor antagonist aphosphonopentanoic acid. The implication of these results is that long-lasting potentiation in the dentate gyrus can be produced by more than one beta-adrenergic-activated mechanism.
authors.affiliation: School of Human Development, University of Texas at Dallas, Richardson 75080.
authors.forename: D
authors.initials: D
authors.lastname: Dahl
authors.forename: J
authors.initials: J
authors.lastname: Li
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004334:Drug Administration Schedule; D004357:Drug Synergism; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
chemical_list: D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate; D008790:Metoprolol; D007545:Isoproterenol; D009638:Norepinephrine