Inflammatory linear verrucous epidermal naevus with auto-immune thyroiditis: coexistence of two auto-immune epithelial inflammations?
We report a patient with an inflammatory linear verrucous epidermal naevus (ILVEN) coexisting with an auto-immune lymphocytic thyroiditis. The occurrence of two epithelial inflammatory processes could be linked and raises the question of auto-immune involvement in the inflammatory part of ILVEN. Moreover, expression of a membrane antigen, OKM5, usually assigned to antigen-presenting cells, especially macrophages, has been demonstrated on keratinocytes in some dermatological diseases including ILVEN. These data suggest that keratinocytes in ILVEN could present some antigens and perhaps auto-antigens modified by the hamartomatous process, leading to an (auto-immune?) inflammatory reaction.
Dereure
O
O
Department of Dermatology-Phlebology, Hôpital Saint-Charles, Montpellier, France.
Paillet
C
C
Bonnel
F
F
Guilhou
J J
JJ
D000328:Adult; D001324:Autoantigens / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications; D005260:Female; D006222:Hamartoma / Q000150:complications* / Q000276:immunology; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D012871:Skin Diseases / Q000150:complications* / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications*
D001324:Autoantigens