European experience with artex: the Tertatolol International Multicentre Study (TIMS).
The Tertatolol International Multicentre Study (TIMS) was aimed at assessing the efficacy and acceptability of 5 mg tertatolol (T) once daily over a 1-year period. The study was carried out in 230 patients (96 men, 134 women, mean age 51.5 +/- 0.7 years) with uncomplicated mild-to-moderate hypertension. After a 1-month placebo run-in period followed by a 1-month double blind placebo-controlled period, 213 patients entered and 166 completed the 1-year open period. A diuretic (D) was added if blood pressure (BP) was inadequately controlled with tertatolol alone. After 1 year, 88.5% of patients were controlled (sitting diastolic BP < or = 90 mmHg): 56.3% on single therapy (T) and 32.2% on dual therapy (T+D), respectively. After a 1-month double-blind period, the incidence of emergent symptoms was not significantly different between the placebo group and the tertatolol group. This low incidence was also observed over the 1-year period, side effects leading to the discontinuation of the treatment in 9.1% of the cases. In patients whose creatinine level was initially higher than 100 mumol/l, tertatolol significantly decreased creatinine level in the single but not in the dual therapy group. This study confirms that tertatolol is an efficient and well-tolerated antihypertensive drug, which improves renal function.
Laher
M S
MS
James Connolly Memorial Hospital, Dublin, Ireland.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000009:adverse effects / Q000627:therapeutic use*; D013876:Thiophenes; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D011412:Propanolamines; D013876:Thiophenes; C005632:tertatolol