Management of giardiasis by an immuno-modulatory herbal drug Pippali rasayana.
Pippali rasayana (PR), an Ayurvedic herbal medicine, prepared from Piper longum (Pippali) and Butea monosperma (Palash), and prescribed for the treatment of chronic dysentery and worm infestations was tested for anti-giardial and immuno-stimulatory activity in mice, infected with Giardia lamblia trophozoites. It produced up to 98% recovery from the infection. The rasayana had no killing effect on the parasite in vitro. It induced significant activation of macrophages as evidenced by increased macrophage migration index (MMI) and phagocytic activity. Enhancement of host resistance could be one of the possible mechanisms contributing towards the recovery of animals from the giardial infection.
Agarwal
A K
AK
Division of Biochemistry and Microbiology, Central Drug Research Institute, Lucknow, India.
Singh
M
M
Gupta
N
N
Saxena
R
R
Puri
A
A
Verma
A K
AK
Saxena
R P
RP
Dubey
C B
CB
Saxena
K C
KC
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016829:Giardia lamblia / Q000187:drug effects; D005873:Giardiasis / Q000188:drug therapy*; D006384:Hemagglutination / Q000187:drug effects; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal