title: Plasma gastrin and somatostatin levels in newborn infants receiving supplementary formula feeding.
abstract: Plasma gastrin and somatostatin concentrations were measured by radioimmunoassay in exclusively formula-fed infants and in breast-fed infants receiving supplementary formula during the first five postnatal days. Infants exclusively formula fed had a progressive increase in mean plasma gastrin concentration from 109 +/- 42 pmol/l (mean +/- SD) on the first day to 236 +/- 103 pmol/l on the fifth day after birth (p = 0.0001). Breast-fed infants receiving supplementary formula had similar hormone concentrations as formula-fed infants of corresponding postnatal age and they also had a significant increase in hormone levels from the first to the fifth day (p = 0.0001). A positive relationship was found between gastrin concentration and ingested milk volume: Rs = 0.51, n = 105, p = 0.0001. The high gastrin concentrations most probably reflect enhanced hormonal release from the gastrin-producing cells in response to increasing volumes of milk ingested by the infant. The mean plasma somatostatin concentration on the first day after birth was 18 +/- 6 pmol/l. No significant change occurred during the first five postnatal days, independent of feeding type.
authors.affiliation: Department of Paediatrics, KS-St Göran, Karolinska Hospital, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Marchini
authors.forename: M R
authors.initials: MR
authors.lastname: Simoni
authors.forename: F
authors.initials: F
authors.lastname: Bartolini
authors.forename: K
authors.initials: K
authors.lastname: Uvnäs-Moberg
mesh_terms: D005260:Female; D005527:Food, Fortified; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn / Q000502:physiology*; D008297:Male; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood*
chemical_list: D005755:Gastrins; D013004:Somatostatin