title: Polymorphonuclear neutrophil chemotaxis in Chinese patients with post-juvenile periodontitis and rapidly progressive periodontitis.
abstract: The purpose of this study was to investigate polymorphonuclear neutrophil (PMN) chemotaxis in Chinese patients with post-juvenile periodontitis (post-JP) and rapidly progressive periodontitis (RPP). Peripheral blood PMNs were isolated from nine post-JP and 13 RPP patients. Eight patients with adult periodontitis (AP) and seven clinically healthy subjects were used for comparison. Clinical data, including the plaque index and gingival index, of each subject were recorded. The "modified Boyden chamber technique" was used for PMN chemotaxis assay. Our results showed that the PMN chemotaxis index in patients with post-JP and RPP were significantly depressed compared to that in healthy subjects or patients with AP. There was no significant difference in PMN chemotaxis between post-JP and RPP, or between AP and healthy subjects. There was also no significant correlation between the plaque index, or gingival index, and PMN chemotaxis in any group. These results suggest that there is a PMN chemotaxis defect in most Chinese patients affected by post-JP or RPP, and that the PMN chemotaxis defect is not associated with clinical parameters such as the plaque index or gingival index.
authors.affiliation: Department of Periodontics, National Taiwan University Hospital, Taipei, R.O.C.
authors.forename: Y L
authors.initials: YL
authors.lastname: Yang
authors.forename: L T
authors.initials: LT
authors.lastname: Hou
authors.forename: W K
authors.initials: WK
authors.lastname: Chang
mesh_terms: D000328:Adult; D002634:Chemotaxis, Leukocyte; D003774:Dental Plaque Index; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils; D010512:Periodontal Index; D010518:Periodontitis / Q000276:immunology / Q000503:physiopathology*; D013624:Taiwan