p53 mutation hotspot in radon-associated lung cancer.
Mutations in gene p53 are the most common defects in lung cancer and may be a pathway through which environmental carcinogens initiate cancer. We investigated p53 mutations in lung cancers from uranium miners with high radon exposure. 16 (31%) of 52 large-cell and squamous-cell cancers from miners contained the same AGG to ATG transversion at codon 249, including cancers from 3 or 5 miners who had never smoked. This specific mutation has been reported in only 1 of 241 published p53 mutations from lung cancers. The codon 249 mutation may be a marker for radon-induced lung cancer.
Taylor
J A
JA
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Watson
M A
MA
Devereux
T R
TR
Michels
R Y
RY
Saccomanno
G
G
Anderson
M
M
D016022:Case-Control Studies; D003062:Codon / Q000235:genetics; D005091:Exons / Q000235:genetics; D016158:Genes, p53 / Q000528:radiation effects*; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008906:Mining; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics*; D009784:Occupational Diseases / Q000209:etiology / Q000235:genetics*; D011886:Radon / Q000009:adverse effects*; D014501:Uranium
D003062:Codon; D014501:Uranium; D011886:Radon