title: IMOL 881, a new trypanocidal compound.
abstract: A new drug molecule (IMOL 881) was synthesized and is showing interesting trypanocidal properties. The test results on animal models indicate activity against several trypanosome species, both in the veterinary and in the human medicine application fields. The species tested so far include: T. evansi, T. equiperdum, T. gambiense and T. rhodesiense. The good activity combined with a relatively low toxicity results in a high therapeutic index (> 100). In addition to its curative properties, the drug also seems to exhibit a prophylactic potential, as evidenced by tests on drug treated mice, subsequently infected with T. evansi.
authors.affiliation: Institute of Molecular Biology, Vrije Universiteit Brussel, St. Genesius-Rode, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Maes
authors.forename: E B
authors.initials: EB
authors.lastname: Songa
authors.forename: R
authors.initials: R
authors.lastname: Hamers
mesh_terms: D000818:Animals; D001152:Arsenicals / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D014227:Triazines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014345:Trypanosoma / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000469:parasitology / Q000662:veterinary
chemical_list: D001152:Arsenicals; D014227:Triazines; D014344:Trypanocidal Agents; C084448:IMOL 881