[Prognostic significance of Helicobacter pylori isolation in patients with peptic ulcer].
The author shows that persistent contamination of the mucosa in ulcer patients noticeable even after ulcer healing with Helicobacter pylori leads to disordered coordination of energetic processes in immunocompetent cells. The reserve pathway becomes more active than basic pathway of oxidation, this combining with lymphocyte sensitization to the mucosal tissue. An unfavourable prognostic implication is given to a 1.5-fold inhibition of lymphocyte succinate dehydrogenase activity. If alpha-glycerophosphate dehydrogenase is 2.3 times higher than normal and leukocyte migration index is under 0.65, the prognosis is also likely to be unfavourable.
Serebrianskaia
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MV
D000328:Adult; D004796:Clinical Enzyme Tests; D004381:Duodenal Ulcer / Q000175:diagnosis; D005753:Gastric Mucosa / Q000382:microbiology*; D005993:Glycerolphosphate Dehydrogenase / Q000097:blood; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006651:Histocytochemistry; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D008875:Middle Aged; D010437:Peptic Ulcer / Q000175:diagnosis*; D011379:Prognosis; D013276:Stomach Ulcer / Q000175:diagnosis; D013385:Succinate Dehydrogenase / Q000097:blood
D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase
Prognosticheskaia znachimost' vydeleniia Helicobacter pylori u bol'nykh iazvennoĭ bolezn'iu.