[Stimulating effects of a calcium antagonist foridon on absorption detected by segmental perfusion of the small intestine].
A continuous perfusion of the jejunal segment has been performed in 18 patients with chronic intestinal diseases. The addition of 40 mg foridon, a calcium antagonist from dihydropyridine series increased the absorption rate of glucose, Na+ and water by 28.0%, 44.3% and 41.1%, respectively. The stimulating effect was independent of basal absorption and did not impair the absorption. It is planned to test foridon and other calcium antagonists as antidiarrheal medication.
Parfenov
A I
AI
Fazylov
A V
AV
Poleva
N I
NI
D000328:Adult; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007410:Intestinal Diseases / Q000378:metabolism*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D014867:Water / Q000378:metabolism
D002121:Calcium Channel Blockers; D014867:Water; D012964:Sodium; D009543:Nifedipine; D005947:Glucose; C045912:ryodipine
Stimuliruiushchee deĭstvie antagonista kal'tsiia foridona na vsasyvanie, vyiavlennoe s pomoshch'iu segmentarnoĭ perfuzii tonkoĭ kishki.