A HTLV-I carrier who showed various symptoms and antibodies of autoimmune diseases.
We report a 37-year-old female HTLV-I carrier with complicating primary biliary cirrhosis (PBC) and mixed connective tissue disease (MCTD). Serum anti-HTLV-I antibody titer was x256. Flower cells (4.5%) were found in the peripheral blood. Southern blot analysis showed no clonal integration in peripheral blood lymphocyte (PBL) DNA. Polymerase chain reaction showed the HTLV-I genome in PBL DNA. As cholestatic liver dysfunction and serum titer of anti-mitochondrial antibody were found, a clinical diagnosis of PBC was made. This patient later developed MCTD. These diseases responded well to prednisone. The pathogenetic relationship of HTLV-I infection with various autoimmune diseases is discussed.
Mizuki
M
M
Department of Clinical Research, Osaka University, Japan.
Tagawa
S
S
Shibano
M
M
Okamoto
Y
Y
Nojima
J
J
Sakata
K
K
Takatsuki
K
K
Kawata
S
S
Hashimoto
M
M
Hashimoto
K
K
D000328:Adult; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D002353:Carrier State / Q000276:immunology*; D004279:DNA, Viral / Q000097:blood; D015480:Deltaretrovirus Antibodies / Q000097:blood; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008214:Lymphocytes / Q000382:microbiology; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D016133:Polymerase Chain Reaction; D011129:Polyradiculoneuropathy / Q000150:complications; D011241:Prednisone / Q000627:therapeutic use
D001323:Autoantibodies; D004279:DNA, Viral; D015480:Deltaretrovirus Antibodies; D006680:HLA Antigens; D011241:Prednisone