The trypanocidal effect of Cannabis sativa constituents in experimental animal trypanosomiasis.
The effect of Cannabis sativa on trypanosome-infected rats was examined. An aqueous extract of the seeds administered at a dose of 50 mg/kg/d cured animals infected with Trypanosome brucei brucei of blood stream parasites. Six fractions eluted from the crude extract by column chromatography were assessed for trypanocidal properties. Of these, only 2 fractions retained trypanocidal activity by curing mice infected with T brucei brucei.
Nok
A J
AJ
Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
Ibrahim
S
S
Arowosafe
S
S
Longdet
I
I
Ambrose
A
A
Onyenekwe
P C
PC
Whong
C Z
CZ
D000818:Animals; D002186:Cannabinoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002188:Cannabis / Q000737:chemistry*; D005591:Chemical Fractionation; D002845:Chromatography; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012639:Seeds / Q000737:chemistry; D014346:Trypanosoma brucei brucei / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D002186:Cannabinoids; D010936:Plant Extracts