title: Negligible hemostatic toxicity of intermediate-dose Erwinase in adult patients with acute lymphoblastic leukemia: preliminary data.
abstract: The hemostatic toxicity of low dose L-asparaginase from Erwinia carotovora (Erwinase) has been reported to be negligible in adult patients with acute lymphoblastic leukemia (ALL); conversely, no consistent data have been obtained when Erwinase is administered at intermediate doses. We report preliminary clinical and laboratory hemostatic data from 10 adult patients with ALL treated during induction phase with intermediate doses of Erwinase (20,000 IU/m2s.c. every other day, for a total of six administrations). No thrombotic or hemorrhagic events were registered and the mean values of PT, aPTT, fibrinogen, antithrombin and D-dimer did not change during treatment. Only one patient showed a decrease of antithrombin (48% on day 8) requiring temporary suspension of Erwinase therapy. These data suggest that intermediate doses of Erwinase also have negligible hemostatic toxicity in adult patients with ALL.
authors.affiliation: Hematology Institute L. & A. Seràgnoli, University of Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Nocentini
authors.forename: L
authors.initials: L
authors.lastname: Gugliotta
authors.forename: L
authors.initials: L
authors.lastname: Catani
authors.forename: N
authors.initials: N
authors.lastname: Vianelli
authors.forename: S
authors.initials: S
authors.lastname: Baravelli
authors.forename: V
authors.initials: V
authors.lastname: Martelli
authors.forename: S
authors.initials: S
authors.lastname: Tura
mesh_terms: D000293:Adolescent; D000328:Adult; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016973:Pectobacterium carotovorum / Q000201:enzymology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D001426:Bacterial Proteins; D001215:Asparaginase