Ciliotoxicity of methyl- and propyl-p-hydroxybenzoates: a dose-response and surface-response study.
The effect of methyl-p-hydroxybenzoate (methyl paraben, MHB) and propyl-p-hydroxybenzoate (propyl paraben, PHB) on ciliary beat frequency was investigated using surface-response methodology. Both compounds are shown to be ciliotoxic at concentrations equal to or lower than those in use for preserving aqueous formulations. The dose-response curves show the typical sigmoidal pattern. Interaction by the two compounds is evidenced by the curved response surface for ciliotoxicity.
Jian
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L
Drug Delivery Research Group, School of Pharmacy, Queen's University of Belfast, UK.
Li Wan Po
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D000818:Animals; D002923:Cilia / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D010226:Parabens / Q000633:toxicity*; D000091402:Prohibitins; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet; D013499:Surface Properties; D014132:Trachea / Q000166:cytology / Q000187:drug effects
D010226:Parabens; C000717332:Phb protein, rat; D000091402:Prohibitins; C015358:methylparaben; C006068:propylparaben