[Antagonism of daurisoline on arrhythmogenic delayed afterdepolarization].
Standard microelectrode technique was used to study the effect of daurisoline (DS) on delayed afterdepolarization (DAD) and triggered activity (TA) in guinea pig ventricular trabeculae. DS (50 mumol.L-1) abolished TA induced by ouabain or caffeine, inhibited isoprenaline-induced TA, decreased incidence of TA induced by K(+)-free and high-Ca2+ medium or phenylephrine from 100.75% to 9.1% and 22.2% respectively, and significantly suppressed DAD caused by the above induces. It is concluded that DS exert antagonistic action to DAD and TA in guinea pig trabeculae.
Wang
Z X
ZX
Department of Clinical Pharmacology, Tongji Medical University, Wuhan.
Zhu
J Q
JQ
Zeng
F D
FD
Hu
C J
CJ
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D044182:Benzylisoquinolines; D004594:Electrophysiology; D006168:Guinea Pigs; D008839:Microelectrodes; D010210:Papillary Muscles / Q000503:physiopathology
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D044182:Benzylisoquinolines; C023968:daurisoline