[Significance of sympathetic-adrenal structures in hematopoiesis regulation in cytostatic myelodepression].
The role of the sympathetic nervous system in the regulation of bone marrow hematopoiesis has been studied on mice CBA after administration of 5-fluorouracil (114 mg/kg). The double injection (3-5 minutes before and 5 hours after 5 + U) of ganglionic blocking drug (pentamine, 6 mg/kg), alpha-adrenergic (dihydroergotamine, 3.9 mg/kg) or beta-adrenergic antagonists (propranolol, 5 mg/kg) inhibited the post-cytostatic reparation of erythro- and granulocytopoiesis. Besides, addition of the same neurotropic antagonists and 5-FU (10(-7) M) to bone marrow culture led to 1.5-3 fold decrease of cell content in comparison with alone cytostatic after 24 hours incubation. On the contrary injection of neuroblocking agents (twice in 5 hours) on day 3 after 5-FU administration elevated the total count of erythroid cells immature and mature granulocytic leukocytes in bone marrow and polymorphonuclear leukocytes in blood. Thus, the unequal role of the sympathetic nervous system in the regulation of hematopoiesis at the different periods after high dose of 5-FU administration has been demonstrated.
Khlusov
I A
IA
Dygaĭ
A M
AM
Aksinenko
S G
SG
Gol'dberg
E D
ED
D000311:Adrenal Glands / Q000503:physiopathology*; D000818:Animals; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D002478:Cells, Cultured; D004087:Dihydroergotamine / Q000494:pharmacology; D015672:Erythroid Precursor Cells / Q000187:drug effects; D005472:Fluorouracil / Q000037:antagonists & inhibitors; D005730:Ganglionic Blockers / Q000494:pharmacology; D006098:Granulocytes / Q000187:drug effects; D006410:Hematopoiesis / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011433:Propranolol / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D005730:Ganglionic Blockers; D000644:Quaternary Ammonium Compounds; D004087:Dihydroergotamine; C040648:pentamine; D011433:Propranolol; D005472:Fluorouracil
Znachenie simpatiko-adrenalovykh struktur reguliatsii gemopoéza pri tsitostaticheskoĭ mielodepressii.