title: Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics.
abstract: Since gamma-hydroxybutyrate receptor agonists exhibit dopaminergic regulatory properties and neuroleptic-like effects in neuropharmacological tests, the common neuroleptics were tested for [3H] gamma-hydroxybutyrate binding activity on rat brain membranes. (-)-Sulpiride, sultopride, amisulpride and prochlorperazine possess affinity for the gamma-hydroxybutyrate site(s), consistent with their therapeutic dosage. This study has revealed that gamma-hydroxybutyrate receptors represent an additional target for antipsychotics.
authors.affiliation: Centre de Neurochimie, UPR 416 du CNRS, Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Maitre
authors.forename: C
authors.initials: C
authors.lastname: Ratomponirina
authors.forename: S
authors.initials: S
authors.lastname: Gobaille
authors.forename: Y
authors.initials: Y
authors.lastname: Hodé
authors.forename: V
authors.initials: V
authors.lastname: Hechler
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000493:pharmacokinetics*; D001549:Benzamides / Q000493:pharmacokinetics*; D001667:Binding, Competitive; D066298:In Vitro Techniques; D008297:Male; D011346:Prochlorperazine / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012978:Sodium Oxybate / Q000493:pharmacokinetics*
chemical_list: C039403:4-hydroxybutyric acid receptor; D014150:Antipsychotic Agents; D001549:Benzamides; D011956:Receptors, Cell Surface; D012978:Sodium Oxybate; D011346:Prochlorperazine