In vitro but not in vivo inhibition of CYP2D6 by phenethyl isothiocyanate (PEITC), a constituent of watercress.
Caporaso
N
N
Genetic Epidemiology Branch, National Cancer Institute, Rockville, MD 20892.
Whitehouse
J
J
Monkman
S
S
Boustead
C
C
Issaq
H
H
Fox
S
S
Morse
M A
MA
Idle
J R
JR
Chung
F L
FL
D000328:Adult; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D019389:Cytochrome P-450 CYP2D6; D065607:Cytochrome P-450 Enzyme Inhibitors; D003647:Debrisoquin / Q000378:metabolism; D005260:Female; D006801:Humans; D017879:Isothiocyanates / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D010944:Plants / Q000737:chemistry*
D016588:Anticarcinogenic Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D017879:Isothiocyanates; C058305:phenethyl isothiocyanate; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D003647:Debrisoquin