title: 2-Chlorodeoxyadenosine is an active salvage therapy in advanced indolent non-Hodgkin's lymphoma.
abstract: OBJECTIVE
  To determine the response rate to 2-chlorodeoxyadenosine (2-CdA; cladribine) in patients with advanced indolent non-Hodgkin's lymphoma (NHL) who fail to respond to or progress after a response to standard chemotherapy drugs.
  
  
  METHODS
  Twenty-one patients were treated with at least one cycle of 2-CdA 0.1 mg/kg/d by continuous infusion for 5 or 7 days.
  
  
  RESULTS
  The overall response rate (complete response [CR] and partial response [PR]) was nine of 21 patients (43%; 95% confidence interval, 22% to 64%). Unmaintained durable responses (longest follow-up, 29+ months) have been observed. The treatment was well tolerated by all patients. The major toxicity was related to myelosuppression (predominantly neutropenia) and immunosuppression with infection.
  
  
  CONCLUSIONS
  The purine analog 2-CdA is an active salvage therapy in pretreated patients with indolent NHL, and deserves further assessment in untreated patients and in combination with other chemotherapy agents.
authors.affiliation: Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
authors.forename: M
authors.initials: M
authors.lastname: Hoffman
authors.forename: M S
authors.initials: MS
authors.lastname: Tallman
authors.forename: D
authors.initials: D
authors.lastname: Hakimian
authors.forename: D
authors.initials: D
authors.lastname: Janson
authors.forename: D
authors.initials: D
authors.lastname: Hogan
authors.forename: D
authors.initials: D
authors.lastname: Variakogis
authors.forename: T
authors.initials: T
authors.lastname: Kuzel
authors.forename: L I
authors.initials: LI
authors.lastname: Gordon
authors.forename: K
authors.initials: K
authors.lastname: Rai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017338:Cladribine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016879:Salvage Therapy; D016896:Treatment Outcome
chemical_list: D017338:Cladribine