title: Structure determination of biliary metabolites of schizandrin in rat and dog.
abstract: After oral administration of schizandrin (1) to rat, the bile was collected and treated with beta-glucuronidase and arylsulfatase. Eleven metabolites, SZ-M0 (3), SZ-M1 (4), SZ-M2 (5), SZ-M3 (6), SZ-M4 (7), SZ-M5 (8), SZ-M6 (9), SZ-M7 (10), SZ-M8 (11), SZ-M9 (12) and SZ-M10 (13) were isolated from the bile treated with the enzymes. The bile after oral administration of 1 to dog was collected and treated with enzymes in the same way, and eight metabolites, 3-8, 10 and SZ-MD2 (14) were isolated from the bile treated with enzymes. The structures of these metabolites were determined on the basis of chemical and spectral studies. The major metabolite in the bile of rat was 7 and the major metabolites in the bile of dog were 7 and 14.
authors.affiliation: Tsumura Central Research Laboratories, Tsumura & Co., Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeya
authors.forename: K
authors.initials: K
authors.lastname: Sugama
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Wakamatsu
authors.forename: H
authors.initials: H
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Oyama
authors.forename: M
authors.initials: M
authors.lastname: Maruno
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D034242:Cyclooctanes; D004285:Dogs; D017705:Lignans / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000378:metabolism; D051381:Rats
chemical_list: D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; C011105:schizandrin