Poly(A) and translation: development control.
The stage-specific translational control of maternal mRNAs is determined by their differential polyadenylation and deadenylation. In the past year, a growing number of cis-acting elements that both positively and negatively regulate polyadenylation and deadenylation have been delineated. Considerable progress has been made on the biochemical characterization and regulation of trans-acting polyadenylation and deadenylation factors. This review summarizes these advances and their relevance to the roles of polyadenylation and deadenylation in translational control.
Wormington
M
M
University of Virginia, Charlottesville.
D000818:Animals; D001483:Base Sequence; D001755:Blastocyst / Q000378:metabolism; D005095:Exoribonucleases / Q000235:genetics / Q000378:metabolism; D005306:Fertilization; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D051379:Mice; D008969:Molecular Sequence Data; D009865:Oocytes / Q000378:metabolism; D011061:Poly A / Q000235:genetics* / Q000378:metabolism*; D011062:Polynucleotide Adenylyltransferase / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000378:metabolism; D014981:Xenopus; D015053:Zygote / Q000378:metabolism; D039221:mRNA Cleavage and Polyadenylation Factors
D005095:Exoribonucleases; D005656:Fungal Proteins; D011061:Poly A; D011062:Polynucleotide Adenylyltransferase; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D039221:mRNA Cleavage and Polyadenylation Factors