title: [The normal fibrinolytic activity of the oral mucosa and saliva and in pathology].
abstract: Local fibrinolysis was studied of oral cavity in healthy individuals (n = 20) and in patients suffering from inflammatory changes in the mucous membrane of the oral cavity (n = 23). Comparison of the results was done with reference to the indicators of the systemic fibrinolysis activity in the same persons. There has been revealed a definite fibrinolytic activity of saliva, particularly its mucinous component. In healthy subjects it is significantly higher as compared to the patients. The local fibrinolysis is provided by the activator of plasminogen rather than the enzyme plasmin. The mucous membrane of the oral cavity does not possess physiologically significant activity since the tissue activator of plasminogen it contains is extracted with 2M solution of potassium thiocyanate only. No shifts of systemic fibrinolytic potential have been revealed in inflammatory changes of the mucous membrane.
authors.forename: S I
authors.initials: SI
authors.lastname: Zhad'ko
mesh_terms: D003778:Dentures / Q000009:adverse effects*; D005341:Fibrinolysin / Q000032:analysis; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D009061:Mouth Mucosa / Q000737:chemistry / Q000502:physiology*; D010960:Plasminogen Activators / Q000032:analysis; D012016:Reference Values; D012463:Saliva / Q000737:chemistry / Q000502:physiology*; D013282:Stomatitis, Denture / Q000503:physiopathology*
chemical_list: D010960:Plasminogen Activators; D005341:Fibrinolysin
vernacular_title: Fibrinoliticheskaia aktivnost' slizistoĭ obolochki polosti rta i sliuny v norme i pri patologii.