The inhibitory effect of sulfated schizophyllans and related oligosaccharides on coagulation and fibrinolysis.
Sulfated schizophyllans and sulfated oligosaccharides were prepared and their inhibitory effects on coagulation and fibrinolysis were examined. Some sulfated schizophyllans, which had a sulfur content of more than 10%, prolonged prothrombin time (PT) and thrombin time (TT). Interestingly, some sulfated schizophyllans and related oligosaccharides were able to inhibit plasmin toward fibrinolysis and amidolysis.
Hirata
A
A
Research Laboratory, Taito Co., Ltd., Kobe, Japan.
Nagamatsu
Y
Y
Itoh
W
W
Tabata
K
K
Yamamoto
J
J
Okada
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002240:Carbohydrate Sequence; D002417:Cattle; D010450:Endopeptidases / Q000378:metabolism; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009844:Oligosaccharides / Q000494:pharmacology*; D011517:Prothrombin Time; D012566:Sizofiran / Q000494:pharmacology*; D013918:Thrombin Time
D009844:Oligosaccharides; D012566:Sizofiran; D010450:Endopeptidases; D005341:Fibrinolysin