Discriminative stimulus properties of 7-OH-DPAT, a dopamine D3-selective receptor ligand.
7-Hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) is a high affinity and selective ligand at dopamine D3 receptors. Rats were trained to discriminate 7-OH-DPAT (0.05 mg/kg) from drug vehicle using a food-reinforced (FR 10) two-lever operant procedure. Six out of nine rats learned to discriminate 7-OH-DPAT, requiring a mean of 29 training sessions. After the training dose was increased to 0.10 mg/kg the remaining three rats reached discrimination performance criterion. The 7-OH-DPAT stimulus was dose-dependent. Doses of 0.01, 0.03, 0.056, and 0.1 mg/kg 7-OH-DPAT produced 0, 11, 78, and 100% drug-correct lever selection, respectively, with the ED50 value calculated to be 0.038 mg/kg. These results demonstrate that the D3-selective ligand 7-OH-DPAT can control differential operant responding in rats on the basis of its discriminative stimulus properties.
McElroy
J F
JF
DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0400.
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects*; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005795:Generalization, Stimulus / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D015259:Dopamine Agents; C493595:Drd3 protein, rat; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; C031349:7-hydroxy-2-N,N-dipropylaminotetralin