title: Interferon-alpha 2a therapy in CML: disappearance of BCR/ABL transcript in a case of long-lasting continuous cytogenetic conversion.
abstract: Seventy months after diagnosis, minimal residual disease is undetectable in a patient with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) in long-lasting continuous cytogenetic conversion (CCC), achieved through alpha 2a-interferon (IFN-alpha) therapy. Fluctuating molecular remission, evaluated with the two-stage reverse transcriptase-polymerase chain reaction (RT-PCR) with nested primers, has persisted for two years at the maximum tolerable dose of IFN alpha (1.5 x 10(6) IU per day).
authors.affiliation: Istituto di Ematologia, Università di Sassari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Pardini
authors.forename: M
authors.initials: M
authors.lastname: Addis
authors.forename: F
authors.initials: F
authors.lastname: Dore
authors.forename: S
authors.initials: S
authors.lastname: Bonfigli
authors.forename: R M
authors.initials: RM
authors.lastname: Nieddu
authors.forename: R
authors.initials: R
authors.lastname: Galanello
authors.forename: M
authors.initials: M
authors.lastname: Longinotti
authors.forename: M G
authors.initials: MG
authors.lastname: Pau
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*; D011994:Recombinant Proteins; D012074:Remission Induction
chemical_list: D004273:DNA, Neoplasm; D007155:Immunologic Factors; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D016044:Fusion Proteins, bcr-abl; D006918:Hydroxyurea