title: High-dose narcotic anesthesia using sufentanil in swine for cardiac catheterization and electrophysiologic studies.
abstract: A protocol for high-dose narcotic anesthesia using sufentanil by intravenous infusion was developed in swine undergoing cardiac catheterization and intracardiac electrophysiologic studies. In experiments involving cardiac conduction system ablation, nine swine received intramuscular ketamine, 33 mg/kg, and intramuscular acepromazine, 1.1 mg/kg, as premedication. An infusion of sufentanil (15 mcg/kg/h) was started followed by a loading dose of sufentanil (7 mcg/kg) given as a bolus intravenously. A continuous infusion of sufentanil (15-30 mcg/kg/h) was used for maintenance anesthesia. Since the development of this protocol, we have been able to achieve stable hemodynamics and cardiac rhythms for intracardiac electrophysiologic studies.
authors.affiliation: Medical University of South Carolina, South Carolina Children's Heart Center, Charleston 29425.
authors.forename: R E
authors.initials: RE
authors.lastname: Schumann
authors.forename: M M
authors.initials: MM
authors.lastname: Swindle
authors.forename: B J
authors.initials: BJ
authors.lastname: Knick
authors.forename: C L
authors.initials: CL
authors.lastname: Case
authors.forename: P C
authors.initials: PC
authors.lastname: Gillette
mesh_terms: D000771:Anesthesia, Intravenous / Q000379:methods; D000818:Animals; D006328:Cardiac Catheterization; D004452:Echocardiography; D004562:Electrocardiography; D006439:Hemodynamics / Q000187:drug effects; D007262:Infusions, Intravenous; D007530:Isoflurane / Q000008:administration & dosage; D008954:Models, Biological; D017409:Sufentanil / Q000008:administration & dosage*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D017409:Sufentanil; D007530:Isoflurane