Pentoxifylline-associated reduction of indomethacin-induced rat gastric mucosal injury is supported by decreased lipid peroxidation.
Pentoxifylline pretreatment protects rat gastric mucosa against indomethacin-induced damage. Lipid peroxidation after indomethacin treatment (determined as thiobarbituric acid reactants) was significantly reduced by a single dose of pentoxifylline. The same was true for pentoxifylline administration for 6 days. There is a relationship between reduced lipid peroxidation, decreased number of circulating activated neutrophils and diminished disposition for acute gastric mucosal lesions induced by indomethacin in pentoxifylline-pretreated rats.
Sallingová
Z
Z
Department of Pharmacology, Faculty of Medicine, Safarik University, Slovak Republic.
Kohút
A
A
D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007213:Indomethacin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010431:Pentoxifylline; D007213:Indomethacin