Synthesis and analgesic activity of 2-amino-5-tert-butyl-2-oxazoline.
2-Amino-5-tert-butyl-2-oxazoline (ATBO, 2) was synthetized from 3,3-dimethyl-2-iodobutyl isocyanate via N-(3,3-dimethyl-2-iodobutyl) urea (1). The structures of compounds 1 and 2 are based on analytical and spectroscopic data. Compound 2 induced in rats and mice a peripheral antinociceptive effect through both spinal and supraspinal mechanisms. ATBO did not impair motor coordination or activity of the experimental animals.
Serrano
M I
MI
Department of Pharmacology Medical School, University of Seville, Spain.
Serrano
J S
JS
Fernández
A
A
Sánchez-Carrasco
J M
JM
Fuentes
J
J
Pradera
M A
MA
Ortiz
M C
MC
Garcia Fernández
J M
JM
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
C092590:2-amino-5-tert-butyl-2-oxazoline; D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010080:Oxazoles; D009270:Naloxone; D008713:Methimazole; D009020:Morphine; D019342:Acetic Acid