Peripheral neuropathy after autologous blood stem cell transplantation for multiple myeloma.
We report a case of peripheral neuropathy occurring after autologous blood stem cell transplantation (ABSCT) for multiple myeloma. The patient, free of neurological symptoms, was transplanted in partial remission, and achieved a complete remission after transplantation. A severe peripheral, symmetric, distal sensori-motor polyneuropathy appeared at day 25 and worsened progressively until commencement of corticosteroid therapy. A peripheral nerve biopsy showed endoneurial cellular infiltrates which were predominantly composed of T cells identified by immunocytochemistry. Ultrastructural examination showed acute axonal damage. Electrophysiologic studies performed before and during the treatment were consistent with a severe axonal degeneration and showed a marked improvement, concomitant with the favorable clinical outcome. This is the first report of peripheral neuropathy after ABSCT.
Boiron
J M
JM
Unité de Greffe de Moëlle, Hopital Haut-Lévêque, C.H.R. Bordeaux, France.
Ellie
E
E
Vital
A
A
Marit
G
G
Rème
T
T
Vital
C
C
Broustet
A
A
Reiffers
J
J
D001369:Axons / Q000648:ultrastructure; D001706:Biopsy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000473:pathology; D010543:Peroneal Nerve / Q000473:pathology / Q000648:ultrastructure; D013601:T-Lymphocytes / Q000473:pathology; D014182:Transplantation, Autologous