Spectrum of activity of soluble intercellular adhesion molecule-1 against rhinovirus reference strains and field isolates.
The antiviral potency of soluble intercellular adhesion molecule-1 (ICAM-1; the major receptor for human rhinoviruses) was determined for a subset of American Type Culture Collection reference serotypes and field isolates of rhinovirus. The results indicate that soluble ICAM-1 exhibits a broad spectrum of activity against rhinoviruses and that field isolates have a sensitivity indistinguishable from that of laboratory strains.
Ohlin
A
A
Institute for Inflammation and Experimental Medicine, Miles Biotechnology, West Haven, Connecticut 06516.
Hoover-Litty
H
H
Sanderson
G
G
Paessens
A
A
Johnston
S L
SL
Holgate
S T
ST
Huguenel
E
E
Greve
J M
JM
D015815:Cell Adhesion Molecules / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D008826:Microbial Sensitivity Tests; D011994:Recombinant Proteins / Q000494:pharmacology; D012229:Rhinovirus / Q000187:drug effects*
D015815:Cell Adhesion Molecules; D011994:Recombinant Proteins; D018799:Intercellular Adhesion Molecule-1