Renin gene polymorphism associated with aldosterone responsiveness to the renin-angiotensin system in patients with aldosterone-producing adenomas.
Aldosterone-producing adenomas may be responsive or unresponsive to the renin-angiotensin system. In tumours from patients in the responsive subgroup, renin mRNA is expressed in greater amounts than in tumours from patients in the unresponsive subgroup, or in normal adrenals. We compared the frequency of two renin gene polymorphisms in peripheral blood DNA from the two subgroups and found a significant association (allele frequency X2 = 7.67, p < 0.006) between BglI polymorphism and aldosterone responsiveness. This may be a significant determinant of the biochemical behaviour of these tumours.
Klemm
S A
SA
Endocrine-Hypertension Research Unit, Greenslopes Hospital, Brisbane, Australia.
Ballantine
D M
DM
Gordon
R D
RD
Tunny
T J
TJ
Stowasser
M
M
D000236:Adenoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012083:Renin / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*
D000450:Aldosterone; D012083:Renin