Comparative studies of patients with Takayasu arteritis in Japan, Korea and India--comparison of clinical manifestations, angiography and HLA-B antigen.
Comparative study of Takayasu arteritis in 3 Asian countries (India, Korea and Japan) has revealed some significant differences. In angiographic findings, Japanese patients more frequently have lesions at the aortic arch and/or its branches (99% of 96 cases), while most lesions in Korean (76% of 109 cases) and Indian patients (92% of 50 cases) are at the abdominal aorta. The presence of HLA-Bw52 or B5 is closely associated with Takayasu arteritis in all 3 Asian countries. The complications in 108 Japanese, 101 Korean and 50 Indian patients were also compared. The most frequent complications were aortic regurgitation in Japan and hypertension in the other 2 countries. Death occurred most frequently due to congestive heart failure or sudden death resulting from aortic regurgitation in Japan, but resulting from hypertension in Korea and India.
Yajima
M
M
Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Numano
F
F
Park
Y B
YB
Sagar
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D001022:Aortic Valve Insufficiency / Q000209:etiology; D001027:Aortography; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis; D059950:HLA-B52 Antigen; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007194:India; D007564:Japan; D007723:Korea; D008297:Male; D008875:Middle Aged; D013625:Takayasu Arteritis / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics
D015235:HLA-B Antigens; C035270:HLA-B5 antigen; D059950:HLA-B52 Antigen