title: The effects of CV205-502 in patients with hyperprolactinaemia intolerant and/or resistant to bromocriptine.
abstract: CV205-502 is a new non-ergot dopamine agonist currently being studied for the treatment of hyperprolactinaemia. We have assessed the effects of CV205-502 on prolactin secretion and the clinical consequences of hyperprolactinaemia in 16 patients with hyperprolactinaemia who had previously been unsuccessfully treated with bromocriptine. These patients had been either intolerant of and/or resistant to the effects of bromocriptine. Sixteen patients, all women in an age range between 20 and 49 years (mean 31.5 years), were treated for periods of between 8 and 52 weeks with doses of CV205-502 ranging from 0.075 to 0.3 mg taken once daily at night. Seven out of 10 of the patients, who were intolerant of bromocriptine, tolerated CV205-502 better with fewer side effects although the nature of the side effects was similar to that associated with bromocriptine. Only 1 patient from this group stopped taking CV205-502 due to side effects. Six of 11 patients exhibiting bromocriptine resistance showed a significant reduction in the degree of hyperprolactinaemia but normoprolactinaemia was achieved in only 1. Galactorrhoea ceased in 2 of 6 patients, menstruation resumed in 6 of 11 patients presenting with amenorrhoea, and 2 patients conceived. In patients with bromocriptine intolerance and/or resistance, CV205-502 is useful as a second line treatment.
authors.affiliation: Department of Clinical Endocrinology, Christie Hospital, Manchester, UK.
authors.forename: R
authors.initials: R
authors.lastname: Razzaq
authors.forename: D J
authors.initials: DJ
authors.lastname: O'Halloran
authors.forename: C G
authors.initials: CG
authors.lastname: Beardwell
authors.forename: S M
authors.initials: SM
authors.lastname: Shalet
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy; D000634:Aminoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D001971:Bromocriptine / Q000009:adverse effects; D015259:Dopamine Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004351:Drug Resistance; D004361:Drug Tolerance; D005260:Female; D005687:Galactorrhea / Q000188:drug therapy; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D011247:Pregnancy; D011388:Prolactin / Q000097:blood
chemical_list: D000634:Aminoquinolines; D015259:Dopamine Agents; D001971:Bromocriptine; C046650:quinagolide; D011388:Prolactin