Chromatographic resolution of chiral intermediates in beta-adrenergic blocker synthesis on chiral stationary phases.
The enantiomeric purities of optically active intermediates for beta-adrenergic blocking agents prepared via enzyme-assisted processes can be determined rapidly and with high accuracy using HPLC on commercially available columns with chiral supports [Chiralcel OD, OB; Chiralpak OT(+)]. The dependence of the resolution parameters on the substitution pattern of both hydroxy compounds and their esters is reported.
Ader
U
U
Faculty Number 9, Bergische Universität-GH-Wuppertal, Germany.
Muschalek
V
V
Schneider
M P
MP
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D002728:Chlorohydrins / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D015394:Molecular Structure; D013237:Stereoisomerism
D000319:Adrenergic beta-Antagonists; D002728:Chlorohydrins