Plasma immunoreactive endothelin-1 in primary hyperaldosteronism.
This study evaluated the assessment of plasma endothelin-1 (ET-1) levels in primary aldosteronism and its correlation with other vasoactive hormones such as renin, aldosterone, catecholamines, arginine-vasopressin, and atrial natriuretic peptide. Plasma ET-1 was measured in 12 patients with primary aldosteronism (five adenomas and seven primary hyperplasia) and in 15 normal subjects. No significant differences were found in plasma ET-1 between controls and hypertensive patients both in adenoma and primary adrenal hyperplasia (8.8 + 1.6 pg/mL v 6.2 + 1.4 pg/mL v 6.5 + 1.0 pg/mL, P = NS, respectively). Further, no significant correlations were found among ET-1 and vasoactive hormones. In conclusion, these findings show that there are no differences in ET-1 levels between primary aldosteronism patients and healthy subjects. Circulating ET-1 is not involved in the hypertension in primary aldosteronism.
Veglio
F
F
Department of Medicine and Experimental Oncology, University of Turin, Italy.
Melchio
R
R
Rabbia
F
F
Chiandussi
L
L
D000236:Adenoma / Q000097:blood; D000310:Adrenal Gland Neoplasms / Q000097:blood; D000311:Adrenal Glands / Q000473:pathology; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood* / Q000209:etiology; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged
D016232:Endothelins