Somatostatin therapy in L-asparaginase-induced pancreatitis.
L-Asparaginase-induced pancreatitis is an uncommon but potentially lethal complication. An 8-year-old girl with acute lymphoblastic leukaemia developed acute pancreatitis following treatment with asparaginase. Clinical and laboratory improvements were evident after treatment with somatostatin, with no complications of pancreatitis. Induction therapy for the leukaemia was able to be continued and complete remission was documented during the course of pancreatitis and somatostatin treatment, suggesting a beneficial role of somatostatin in the management of asparaginase-induced pancreatitis.
Cheung
Y F
YF
University Paediatric Unit, Queen Mary Hospital, University of Hong Kong.
Lee
C W
CW
Chan
C F
CF
Chan
K L
KL
Lau
Y L
YL
Yeung
C Y
CY
D000208:Acute Disease; D001215:Asparaginase / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D010195:Pancreatitis / Q000139:chemically induced* / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013004:Somatostatin / Q000627:therapeutic use*
D013004:Somatostatin; D001215:Asparaginase