CD7, CD4 and myeloid antigen-positive acute lymphoblastic leukemia.
We report a case of acute lymphoblastic leukemia (ALL, FAB-L2) with unique cellular characteristics. Leukemic cells were negative for various cytochemical stainings except acid phosphatase. Immunophenotypic studies revealed CD7+, CD4+, CD8-, CD2+, CD3-, CD13+, CD25+, CD33+ and CD34+. The immunoglobulin heavy chain and T-cell receptor beta, gamma and delta chain genes were germline configurations. This patient had a karyotype of complex abnormalities involving Nos. 5 and 7. Leukemic cells showed a prominent response to interleukin-3, granulocyte macrophage colony stimulating factor (GM-CSF) and G-CSF with partial granulocytic differentiation in a colony assay. A binding assay confirmed the presence of both high and low affinity receptors for GM-CSF. These findings suggest that CD7+CD4+CD8-CD3- putative T-cell precursors may retain the capacity to differentiate to myeloid lineage.
Nakase
K
K
Department of Internal Medicine, Yamada Red Cross Hospital, Misono, Japan.
Kita
K
K
Sekine
T
T
Otsuji
A
A
Shirakawa
S
S
Tsuji
K
K
Miyanishi
E
E
Asou
H
H
Kamada
N
N
D015703:Antigens, CD / Q000097:blood*; D000951:Antigens, Neoplasm / Q000097:blood*; D015704:CD4 Antigens / Q000097:blood*; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D015704:CD4 Antigens