Changes of cerebral vasoactive intestinal polypeptide- and somatostatin-like immunoreactivity induced by noise and whole-body vibration in the rat.
To clarify the role of vasoactive intestinal polypeptide (VIP) and somatostatin, somatotropin-release inhibiting factor, (SRIF) neurons in the response to organisms to noise or whole-body vibration stress, VIP- and SRIF-like immunoreactivity were determined in various regions of the rat brain following exposure for 90 min to noise (broad band, 102 dB) or whole-body vibration (20 Hz, 4.0 g). Both noise and whole-body vibration significantly increased VIP-like immunoreactivity in the amygdala. A significant reduction of VIP-like immunoreactivity in the hippocampus was induced only by whole-body vibration. On the other hand, SRIF-like immunoreactivity was decreased significantly in the hypothalamus and increased significantly in the amygdala by noise and whole-body vibration, respectively. The present findings would seem to indicate that the amygdalofugal VIP neural system is involved in regulating hypothalamic and pituitary hormone secretions in non-specific reactions to stress. Responses of hippocampal VIP and the amygdalofugal SRIF to whole-body vibration stress are assumed to be activated as specific reactions to the stress.
Nakamura
H
H
Department of Public Health, Kanazawa University School of Medicine, Japan.
Moroji
T
T
Nagase
H
H
Okazawa
T
T
Okada
A
A
D000818:Animals; D001921:Brain / Q000378:metabolism; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D009622:Noise / Q000009:adverse effects*; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013004:Somatostatin / Q000378:metabolism*; D014018:Tissue Distribution; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*; D014732:Vibration / Q000009:adverse effects*
D010455:Peptides; C029993:somatostatin-like peptides; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin