Familial testicular carcinoma: in search of genetic triggers.
Two cases of testicular tumours in non-twin brothers of a cancer-prone family are described. Cytogenetic studies of these two patients and human leucocyte antigen (HLA) typing of the family failed to identify any genetic defects. The authors propose using linkage analysis for further genetic studies but would require additional families for this to be performed.
Nicol
D
D
Department of Urology, Princess Alexandra Hospital, Queensland, Australia.
Teh
B T
BT
Strachan
N
N
Ward
G
G
Martin
N
N
D000328:Adult; D018236:Carcinoma, Embryonal / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D002874:Chromosome Mapping; D003582:Cytogenetics; D005260:Female; D005500:Follow-Up Studies; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D006680:HLA Antigens / Q000097:blood; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009919:Orchiectomy; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D018239:Seminoma / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D013736:Testicular Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery
D005819:Genetic Markers; D006680:HLA Antigens