Nucleotide sequence of the cDNA encoding mouse thyroid peroxidase.
The nucleotide (nt) sequence of the cDNA encoding mouse thyroid peroxidase (TPO) has been determined. The TPO cDNA is 3281 nt long and its open reading frame encodes a protein composed of 914 amino acids (aa), including a putative initiation Met. The mouse TPO cDNA shows 75.3, 70.8, and 93.5% homology in the coding nt sequence with human, porcine, and rat TPO cDNAs, respectively. In the aa sequence, mouse TPO shows 73.4, 68.4, and 93.9% homology with human, porcine, and rat TPOs, respectively. Specifically, the aa sequence surrounding the proximal His residue, probably essential for TPO activity, is well conserved among these four organisms.
Kotani
T
T
Department of Laboratory Medicine, Miyazaki Medical College, Japan.
Umeki
K
K
Yamamoto
I
I
Takeuchi
M
M
Takechi
S
S
Nakayama
T
T
Ohtaki
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015723:Gene Library; D007453:Iodide Peroxidase / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D007453:Iodide Peroxidase