Serotypes, hemagglutinins, siderophore synthesis, and serum resistance of Klebsiella isolates causing human urinary tract infections.
A total of 146 Klebsiella isolates from human asymptomatic bacteriuria (n = 73), cystitis (n = 54), and acute pyelonephritis (n = 19) were examined for the presence of particular virulence factors. Capsular type K2 was the most common serotype observed (13%). This capsule type was prevalent in isolates from asymptomatic bacteriuria and cystitis but not from pyelonephritis. Type 1 fimbriae were found significantly more often in pyelonephritis isolates than among those from asymptomatic and symptomatic lower urinary tract infection (UTI; P < .05), while no marked differences were detected with respect to the distribution of type 3 fimbriae. Serum resistance was more frequent among isolates from symptomatic (26%) than from asymptomatic UTI (18%). Enterochelin was produced by all but 1 of the isolates as determined by a bioassay. In contrast, aerobactin synthesis was rare (3%), with isolates from pyelonephritis showing the highest frequency of aerobactin production (3/19).
Podschun
R
R
Department of Medical Microbiology and Virology, University of Kiel, Germany.
Sievers
D
D
Fischer
A
A
Ullmann
U
U
D000818:Animals; D001770:Blood Bactericidal Activity; D004758:Enterobactin / Q000032:analysis; D010861:Fimbriae, Bacterial / Q000648:ultrastructure; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D006801:Humans; D006877:Hydroxamic Acids / Q000032:analysis; D007709:Klebsiella / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D007710:Klebsiella Infections / Q000382:microbiology*; D012703:Serotyping; D017262:Siderophores / Q000096:biosynthesis; D014552:Urinary Tract Infections / Q000382:microbiology*; D014774:Virulence
D006877:Hydroxamic Acids; D017262:Siderophores; C031819:aerobactin; D004758:Enterobactin