title: Recovery of medial gastrocnemius muscle grafts in rats: implications for the plantar flexor group.
abstract: Medial gastrocnemius (MGN) muscles were grafted in 18 rats and evaluated at 60, 90, and 120 days after the operation. Our purpose was to investigate the degree of recovery of the vascularized MGN grafts and the entire plantar flexor muscle group. Compared with control values, muscle mass and maximum force of MGN grafts were decreased by 33 and 38% at 60 days, 22 and 32% at 90 days, and 13 and 15% at 120 days. At 60 and 90 days, the deficits in maximum force for the entire plantar flexor muscle group, including the graft, were 29 and 17%, respectively. No difference was observed at 120 days. At 60 days, the deficit in the total mass of the plantar flexor group was 14% compared with control values, but by 90 days no deficit was observed. The restoration of normal plantar flexor group structure and function indicates that the degree of recovery attained by MGN grafts, although not complete, was sufficient to ensure that the performance of the total muscle group was not compromised.
authors.affiliation: Bioengineering Program, University of Michigan, Ann Arbor 48109.
authors.forename: S W
authors.initials: SW
authors.lastname: Miller
authors.forename: C A
authors.initials: CA
authors.lastname: Hassett
authors.forename: T P
authors.initials: TP
authors.lastname: White
authors.forename: J A
authors.initials: JA
authors.lastname: Faulkner
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006614:Hindlimb; D007537:Isometric Contraction; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000648:ultrastructure; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology* / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors