HLA and T-cell receptor polymorphisms in Belgian multiple sclerosis patients: no evidence for disease association with the T-cell receptor.
There are compelling data to indicate that the susceptibility to multiple sclerosis (MS) is inherited, at least in part. Particular HLA genotypes may be associated with MS and recently also polymorphisms in the T-cell receptor (TCR) genes have been reported to correlate with the disease; however, these data have been difficult to confirm. We investigated the TCRA and TCRB chain genes of HLA-typed Belgian CP MS patients employing four DNA restriction fragment length polymorphisms (RFLPs) detected with TCR constant (TCRAC1, TCRBC2) and variable (TCRBV8, TCRBV11) gene segments. Similar frequencies in patients and controls were observed for all RFLPs studied. Although the HLA DR2 genotype was significantly associated with MS, no interactive effects were seen with MS, DR2, TCRAC1, TCRBC2 and TCRBV alleles. We conclude that, while a clear association with HLA DR2 is observed, little convincing evidence exists for an association of CP MS with RFLPs of the TCRA or TCRB chain genes.
Vandevyver
C
C
Department of Immunology/Biotechnology, Dr. L. Willems-Instituut, Diepenbeek, Belgium.
Buyse
I
I
Philippaerts
L
L
Ghabanbasani
Z
Z
Medaer
R
R
Carton
H
H
Cassiman
J J
JJ
Raus
J
J
D000483:Alleles; D005838:Genotype; D015802:HLA-DR2 Antigen / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D012150:Polymorphism, Restriction Fragment Length; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
D015802:HLA-DR2 Antigen; D016693:Receptors, Antigen, T-Cell, alpha-beta