[The effect of rilmenidine on the sympathetic activity of the renal nerve in waking barodenervated rats].
The effects of intracisternal pretreatment with alpha 2-adrenoceptor antagonists which possess imidazoline (idazoxan) or nonimidazoline (yohimbine) structures on the sympatho-inhibitory action of rilmenidine were investigated in conscious sinoaortic denervated rats. Intracisternal injection of rilmendine significantly decreased renal sympathetic nerve activity. Idazoxan pretreatment prevented the sympathoinhibitory action of rilmenidine, whereas yohimbine pretreatment failed. It is concluded that the sympathoinhibitory action of rilmenidine relates more to the interaction with imidazoline receptors than alpha 2-adrenoceptors.
Maĭorov
D N
DN
Chernobel'skiĭ
M A
MA
Medvedev
O S
OS
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D003714:Denervation; D004146:Dioxanes / Q000494:pharmacology; D004347:Drug Interactions; D006439:Hemodynamics / Q000187:drug effects; D019329:Idazoxan; D007668:Kidney / Q000187:drug effects / Q000294:innervation*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D000077769:Rilmenidine; D013329:Structure-Activity Relationship; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology; D015016:Yohimbine / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D004146:Dioxanes; D010080:Oxazoles; D015016:Yohimbine; D000077769:Rilmenidine; D019329:Idazoxan
Vliianie rilmenidina na simpaticheskuiu aktivnost' pochechnogo nerva u bodrstvuiushchikh barodenervirovannykh krys.