title: [Chromosome abnormality and dominant lethality among the F1 generation of mice after gamma-ray irradiation].
abstract: This paper reports on the relationship between chromosome abnormality or dominant lethality and dosage of 0.15-1.56 Gy 60Co gamma-ray irradiation in the F1 generation of mice. The irradiated female mice were mated at 7-12 days after irradiation with unirradiated or irradiated at 22-28 days after irradiation. The fetuses aged 9.5-11 days were recovered from the uterus and lethality and chromosome aberrations were investigated. Results suggested that the rate of fetus with chromosome abnormality increased with dose, and so did dominant lethality rate, and both could fit linear relationship. Increase of translocation carriers in the F1 mice was observed at the dose level of over 1.0 Gy.
authors.affiliation: Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing.
authors.forename: S
authors.initials: S
authors.lastname: Yao
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Dai
authors.forename: C
authors.initials: C
authors.lastname: Gao
authors.forename: L
authors.initials: L
authors.lastname: Wei
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D005260:Female; D005720:Gamma Rays; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014916:Whole-Body Irradiation