Effects of cyclic GMP on smooth muscle relaxation.
Cyclic GMP levels within smooth muscle are affected then by a number of different pathways. Physiologically NO and ANF are probably the two most important regulators for smooth muscle function, but a variety of other mediators and pharmacological agents may also influence this system. Because of the important role that cyclic GMP plays in the control of smooth muscle tone, which clearly includes vascular smooth muscle, it is now and will continue to be in the future an important physiological and biochemical target for research and a pharmacological target for therapeutic agents.
Warner
T D
TD
William Harvey Research Institute, St. Bartholomew's Hospital Medical College London, United Kingdom.
Mitchell
J A
JA
Sheng
H
H
Murad
F
F
D000818:Animals; D006152:Cyclic GMP / Q000096:biosynthesis / Q000494:pharmacology* / Q000502:physiology; D006162:Guanylate Cyclase / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000201:enzymology
D007527:Isoenzymes; D006162:Guanylate Cyclase; D006152:Cyclic GMP