Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.
Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients' prognosis in cases of Borrmann type 4 gastric carcinoma.
Kakeji
Y
Y
Department of Gastroenterologic Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
Maehara
Y
Y
Adachi
Y
Y
Baba
H
H
Mori
M
M
Furusawa
M
M
Sugimachi
K
K
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology*; D000951:Antigens, Neoplasm / Q000032:analysis; D002455:Cell Division; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis; D009697:Nucleolus Organizer Region / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen; D016016:Proportional Hazards Models; D016622:Silver Staining; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis; D015996:Survival Rate
D000951:Antigens, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen