The fission yeast cdc18+ gene product couples S phase to START and mitosis.
Commitment to the cell cycle in fission yeast requires the function of the cdc10+ transcriptional activator at START. The product of the cdc18+ gene is a major downstream target of cdc10+, and transcription of cdc18+ is activated by cdc10+ during passage through START. The cdc18+ function is required for entry into S phase. In addition, the product of the cdc18+ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18+ plays a key role in coupling S phase to START and mitosis.
Kelly
T J
TJ
Imperial Cancer Research Fund Cell Cycle Group, Biochemistry Department, Oxford University, England.
Martin
G S
GS
Forsburg
S L
SL
Stephen
R J
RJ
Russo
A
A
Nurse
P
P
D000595:Amino Acid Sequence; D001483:Base Sequence; D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins; D003001:Cloning, Molecular; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D005800:Genes, Fungal / Q000235:genetics*; D008938:Mitosis / Q000235:genetics; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010507:Periodicity; D010641:Phenotype; D016196:S Phase / Q000235:genetics; D012568:Schizosaccharomyces / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins; D017386:Sequence Homology, Amino Acid; D013489:Suppression, Genetic; D014157:Transcription Factors; D014158:Transcription, Genetic
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D029702:Schizosaccharomyces pombe Proteins; D014157:Transcription Factors; C061178:cdc10 protein, S pombe; C082462:cdc18 protein, S pombe