Elevated platelet phosphatidylinositol bisphosphate in mediated schizophrenics.
Levels of phosphatidyl inositol 4,5-bisphosphate (PIP2) have been measured in platelets from schizophrenic and healthy subjects by means of an immunoassay. Resting platelets from schizophrenic patients contained a significantly increased amount of PIP2 compared to controls. The agonist-stimulated hydrolysis of PIP2 in platelets from the schizophrenic group was also significantly greater than that in platelets from the control group. PIP2 plays an important role in cell signalling, and the observed abnormality may be reflected by an impairment in signal transduction via the inositol phospholipid pathway.
Das
I
I
Department of Psychiatry and Biochemistry, Charing Cross and Westminster Medical School, London, UK.
Essali
M A
MA
de Belleroche
J
J
Hirsch
S R
SR
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates / Q000097:blood* / Q000378:metabolism; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012701:Serotonin / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D012969:Sodium Fluoride / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology
D014150:Antipsychotic Agents; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D012701:Serotonin; D012969:Sodium Fluoride; D013917:Thrombin