Bone density is normal in male rats treated with finasteride.
Bone is an androgen-dependent tissue. It is not known whether normal bony growth and mineralization in males is dependent on testosterone alone, or whether its metabolite, dihydrotestosterone (DHT), also is required. To answer this question, we examined the effect of finasteride, an inhibitor of DHT synthesis, on bone in rats. Three-month-old male rats were treated with placebo, finasteride, or orchidectomy. The bone mineral densities (BMD) of the spine and whole body were measured in vivo by dual x-ray absorptiometry at weeks 0 and 11, and the BMD of the femur and tibia were measured ex vivo at week 11. Histomorphometric analysis was performed on the proximal tibia at week 11. The increase in spine and whole body BMD in finasteride-treated rats did not differ from that in controls, whereas these values were significantly lower in orchidectomized rats. Similarly, the BMD of the femur and tibia and the cancellous bone volume of the proximal tibia in finasteride-treated rats did not differ from those in controls, whereas these values were significantly lower in orchidectomized rats. In summary, bone development and density were normal in rats treated with finasteride. We conclude that selective DHT deficiency is not deleterious to the male rat skeleton.
Rosen
H N
HN
Charles A. Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215.
Tollin
S
S
Balena
R
R
Middlebrooks
V L
VL
Moses
A C
AC
Yamamoto
M
M
Zeind
A J
AJ
Greenspan
S L
SL
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D013196:Dihydrotestosterone / Q000037:antagonists & inhibitors / Q000378:metabolism; D018120:Finasteride / Q000494:pharmacology*; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D015675:Osteocalcin / Q000097:blood; D011467:Prostate / Q000033:anatomy & histology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012669:Seminal Vesicles / Q000033:anatomy & histology; D013131:Spine / Q000187:drug effects; D013739:Testosterone / Q000502:physiology
D013196:Dihydrotestosterone; D015675:Osteocalcin; D013739:Testosterone; D018120:Finasteride; D000469:Alkaline Phosphatase