Serum gamma-glutamyl transpeptidase level and blood pressure in nondrinkers: a possible pathogenetic role of fatty liver in obesity-related hypertension.
Relationships between body mass index, blood pressure (BP) and serum gamma-glutamyl transpeptidase levels were analysed in 859 male and 2,456 female nondrinkers aged 18-59 years. Serum gamma-GTP levels correlated with BP independently of age and body mass index in both men and women. The changes in BP of 391 male nondrinkers aged 35-54 years during a five year period correlated with the changes in serum gamma-GTP levels, independently of BP levels, age, body mass index and serum gamma-GTP at the beginning of the follow-up, and of the changes in body mass index. As the rise in serum gamma-GTP levels in nondrinkers depends largely on the progression in fatty change in the liver cells accompanying increases in the size of body mass, these results suggest a close association between the development of fatty liver and hypertension in obese persons.
Ikai
E
E
Department of Hygiene, Kanazawa Medical University, Ishikawa, Japan.
Honda
R
R
Yamada
Y
Y
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D005723:gamma-Glutamyltransferase / Q000097:blood*
D005723:gamma-Glutamyltransferase