Platelet activating factor and the responses of rat isolated stomach strip to prostaglandin E2.
The effect of platelet activating factor (PAF) on contractions evoked by acetylcholine, 5-hydroxytryptamine (5-HT) and prostaglandin E2 (PGE2) was studied in-vitro on rat stomach strip. Addition of PAF to the organ bath increased PGE- but not 5-HT- or acetylcholine-evoked responses. The effect of PAF was unaffected by atropine, methysergide or indomethacin, but prevented by a specific PAF receptor antagonist BN 52021. The data support a specific interaction between PAF and PGE2 on rat stomach strip.
Izzo
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Department of Experimental Pharmacology, University of Naples, Federico II, Italy.
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Autore
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Capasso
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010972:Platelet Activating Factor / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
D010972:Platelet Activating Factor; D012701:Serotonin; D015232:Dinoprostone; D000109:Acetylcholine