Humoral factors derived from glial cells protect cultured neuroblastoma cells against glutamate toxicity.
The protective effects of glial cells against glutamate cytotoxicity on neuronal cells were studied using clonal neuroblastoma cells and two types of glial cells. Neuronal cells treated with glia-conditioned medium became able to tolerate glutamate toxicity. It is suggested that the preparatory processes against glutamate toxicity might be developed in neurons by the humoral factor(s) released from glial cells.
Amano
S
S
Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
Ohashi
M
M
Ishiko
T
T
Hazama
F
F
D000818:Animals; D003470:Culture Media / Q000494:pharmacology; D005910:Glioma / Q000378:metabolism / Q000473:pathology; D005971:Glutamates / Q000633:toxicity*; D018698:Glutamic Acid; D009447:Neuroblastoma / Q000473:pathology*; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured
D003470:Culture Media; D005971:Glutamates; D018698:Glutamic Acid