Expression of proliferating cell nuclear antigen in invasive ductal carcinoma of the breast.
Formalin-fixed, paraffin-embedded sections from 92 breast cancers (invasive ductal carcinomas) were immunostained with a monoclonal antibody against proliferating cell nuclear antigen (PCNA). The labeling index of PCNA ranged widely from 2 to 76 (mean 24.8)%. The labeling index was classified into three groups: low (< 25%), intermediate (25-50%), high proliferation (> 50%). Younger patients seemed to have a higher labeling index than older ones. The labeling index for tumors < or = 2 cm was lower than that of tumors larger than 2 cm. The labeling index in patients with high estrogen receptor (ER) levels (> 100 fmol/mg cytosol protein) was significantly lower than that in patients with low ER levels (< 10 fmol/mg cytosol protein). In relation to histological type, the labeling index of scirrhous carcinoma was significantly lower than that of papillotubular carcinoma or solid-tubular carcinoma. The high proliferating group had a significantly worse overall survival rate than the low proliferating group. Labeling index was shown to be a possible prognostic indicator.
Horiguchi
J
J
Department of Surgery, Gunma University School of Medicine, Maebashi.
Iino
Y
Y
Takei
H
H
Morishita
Y
Y
Nakajima
T
T
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000556:secondary; D002293:Adenocarcinoma, Scirrhous / Q000235:genetics / Q000473:pathology / Q000556:secondary; D000328:Adult; D000367:Age Factors; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology / Q000556:secondary; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis* / Q000235:genetics; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen; D011960:Receptors, Estrogen / Q000032:analysis; D015996:Survival Rate
D000951:Antigens, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D011960:Receptors, Estrogen