[Effect of somatostatin on the hemodynamic changes induced by acute experimental pancreatitis in the conscious rat].
The aim of this study was to determine the hemodynamic effect of somatostatin, either prophylactically or therapeutically, in shock caused by acute necrohemorragic pancreatitis in conscious rats. For this purpose, radioactive microspheres were used in 3 groups (control pancreatitis, therapeutic somatostatin and prophylactic somatostatin), performing a basal and final hemodynamic study. In the control group, acute necrohemorragic pancreatitis resulted in overwhelming shock with decrease of 55% in cardiac output, 58% in renal blood flow, increase in total peripheral resistances of 342%, and death after 70 min. Therapeutic somatostatin decreased cardiac output by 42%, renal blood flow by 47%, and increased total peripheral resistances by 153%. Prophylactic somatostatin decreased cardiac output by 24%, and renal blooded flow by 28%; it increased peripheral resistances by 146%, and improved survival up to 97 min. In conclusion, therapeutic somatostatin, and particularly prophylactic somatostatin, improved hemodynamic shock after acute necrohemorragic pancreatitis in conscious rats.
Ais
G
G
Servicio de Cirugía, Hospital General de Segovia, Madrid.
Novo
C
C
Ortega
M
M
González
A
A
Jiménez
I
I
López
J
J
Romeo
J M
JM
D000208:Acute Disease; D000818:Animals; D003243:Consciousness; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D010195:Pancreatitis / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012769:Shock / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D013004:Somatostatin / Q000494:pharmacology* / Q000627:therapeutic use*; D015996:Survival Rate
D013004:Somatostatin
Efecto de la somatostatina sobre los cambios hemodinámicos inducidos por la pancreatitis aguda experimental en la rata despierta.