title: Influence of protein malnutrition on teratogenicity of acetylsalicylic acid in rats.
abstract: The effect of protein malnutrition (PM) on the embryotoxicity and teratogenicity of aspirin in rats has been studied. Protein malnourishment was produced from Days 7 to 21 of gestation by limiting the casein content of the diet to 5% in comparison to 20% for the normal animals. Six dose levels of aspirin (50-175 mg kg-1) were administered p.o. from Days 8 to 11 of pregnancy. Aspirin from 75 mg kg-1 d-1 induced growth retardation, embryolethality and teratogenicity, as shown by external, skeletal and visceral malformations. All these effects were potentiated by protein malnutrition.
authors.affiliation: National Organization for Drug Control and Research, Cairo, Egypt.
authors.forename: M R
authors.initials: MR
authors.lastname: Hamed
authors.forename: Y S
authors.initials: YS
authors.lastname: al-Assy
authors.forename: E
authors.initials: E
authors.lastname: Ezzeldin
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D002364:Caseins; D004032:Diet; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced*; D005865:Gestational Age; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011502:Protein-Energy Malnutrition / Q000150:complications*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002364:Caseins; D001241:Aspirin