title: Sex steroid hormones in circulatory shock, sepsis syndrome, and septic shock.
abstract: METHODS
  Estrone (E1), estradiol (E2), testosterone (T), FSH, and LH levels were daily measured during a ten day period in 50 critically ill patients (38 men, 12 post-menopausal women). Patients were separated into four groups: A) no circulatory failure, no sepsis, B) sepsis syndrome without circulatory failure, C) circulatory failure without sepsis syndrome, D) septic shock. Results of hormonal measurements were compared 1) among the 4 groups, 2) between male and female patients, 3) between septic and nonseptic patients. The potential for the infusion of the vasoactive drug dobutamine to induce sex hormonal changes was documented in ten additional septic shock patients by measuring cortisol, E1, and T at base-line and after dobutamine infusion. Changes in active renin and plasma renin activity (PRA) were used as indirect witness of the dobutamine-induced beta 2-stimulation.
  
  
  RESULTS
  A dramatic increase in E1 and E2 levels was observed in women of groups B and D, and only in male patients of group D. In the septic patients, estrogen levels peaked at days 1 and 2 and trended to normal from day 6 after the onset of sepsis, while FSH and LH decreased. No difference was found between survivors and non-survivors. Whatever the group, male patients had low T levels throughout the study. Dobutamine induced a significant increase in active renin levels and a decrease in the regression slope between renin and PRA. Cortisol levels remained normal. No significant change in E1 and T was observed after dobutamine.
  
  
  CONCLUSIONS
  High estrogen levels were specifically observed in patients with sepsis and septic shock, either males or females. Decreased LH and FSH levels were consistent with the negative feed-back effect of high estrogen levels on pituitary secretion. Circulating T levels were decreased in all male patients. We found no correlation between sequential estrogen levels and outcome. These levels were not modified by a dobutamine-induced beta-2 stimulation.
authors.affiliation: Service de réanimation polyvalente-Hôpital B, C.H.R.U. Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Fourrier
authors.forename: A
authors.initials: A
authors.lastname: Jallot
authors.forename: L
authors.initials: L
authors.lastname: Leclerc
authors.forename: M
authors.initials: M
authors.lastname: Jourdain
authors.forename: A
authors.initials: A
authors.lastname: Racadot
authors.forename: J L
authors.initials: JL
authors.lastname: Chagnon
authors.forename: A
authors.initials: A
authors.lastname: Rime
authors.forename: C
authors.initials: C
authors.lastname: Chopin
mesh_terms: D000328:Adult; D000368:Aged; D000808:Angiotensinogen / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects; D004280:Dobutamine / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D012769:Shock / Q000097:blood* / Q000503:physiopathology; D012772:Shock, Septic / Q000097:blood* / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000503:physiopathology
chemical_list: D012739:Gonadal Steroid Hormones; D000808:Angiotensinogen; D004280:Dobutamine; D012083:Renin