Disturbances of T-cell interactions with endothelium and the extracellular matrix proteins in a patient with Takayasu arteritis.
T-cell interactions with endothelium and the extracellular matrix proteins were studied in vitro in a patient with Takayasu arteritis. Markedly enhanced spontaneous adhesiveness to cultured endothelium and collagen IV and fibronectin were found to be paralleled by abolished responses to the costimulating action of collagens I and IV and fibronectin. Those abnormalities were partly corrected by immunosuppressive therapy. Aberrant interactions of T cells with endothelium and the extracellular matrix proteins may underlay the pathogenesis of some forms of vasculitis.
Imiela
J
J
Department of Internal Medicine 1, Railway Administration Hospital, Warsaw, Poland.
Górski
A
A
Dybowska
B
B
Małecki
R
R
Nosarzewski
J
J
D000328:Adult; D002448:Cell Adhesion; D003094:Collagen / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology*; D005260:Female; D005353:Fibronectins / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000502:physiology*; D013625:Takayasu Arteritis / Q000276:immunology*
D005353:Fibronectins; D003094:Collagen