Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.
p58cdc2L1, a protein kinase implicated in apoptotic signaling, is one of eight separate kinases encoded by three tandemly duplicated and linked genes, which we have termed PITSLRE A, B and C. One allele of this complex on chromosome 1 was either deleted or translocated in each of 18 neuroblastoma cell lines with cytogenetically apparent 1p alterations. A protein encoded by this locus, PITSLRE gamma 1, was absent in three of the lines and a smaller, apparently truncated, PITSLRE polypeptide was found in another line. These findings identify a novel gene complex on chromosome 1 that encodes a protein kinase subfamily. We suggest that the PITSLRE locus may harbour one or more tumour suppressor genes affected by chromosome 1p36 modifications in neuroblastoma.
Lahti
J M
JM
Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Valentine
M
M
Xiang
J
J
Jones
B
B
Amann
J
J
Grenet
J
J
Richmond
G
G
Look
A T
AT
Kidd
V J
VJ
D000483:Alleles; D002648:Child; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1; D018844:Cyclin-Dependent Kinases; D005796:Genes; D016147:Genes, Tumor Suppressor; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D009006:Monosomy; D005810:Multigene Family; D009447:Neuroblastoma / Q000201:enzymology / Q000235:genetics*; D011494:Protein Kinases / Q000172:deficiency / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases; D012091:Repetitive Sequences, Nucleic Acid; D017384:Sequence Deletion; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured
D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C447612:CDK11a protein, human; D018844:Cyclin-Dependent Kinases