New basic aspects of the antiphospholipid syndrome.
This article reviews recent changes in our understanding of the basic aspects of the Antiphospholipid syndrome (APS) with special emphasis on interactions with phospholipid binding proteins. We survey the history of the development of tests for the APS, and discuss current methods of detection of antiphospholipid antibodies, clinical events associated with APS, and new concepts regarding the immunological specificity of the antibodies.
Hunt
J E
JE
Department of Immunology, Allergy and Infectious Disease, St George Hospital, University of NSW, Kogarah, Australia.
Adelstein
S
S
Krilis
S A
SA
D017153:Antibodies, Anticardiolipin / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000032:analysis / Q000276:immunology* / Q000378:metabolism; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000266:history / Q000276:immunology*; D001665:Binding Sites; D001792:Blood Platelets / Q000276:immunology; D011464:Epoprostenol / Q000276:immunology; D049673:History, 20th Century; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology; D011486:Protein C / Q000276:immunology; D017293:Protein S / Q000276:immunology; D011516:Prothrombin / Q000276:immunology
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor; D011486:Protein C; D017293:Protein S; D011516:Prothrombin; D011464:Epoprostenol