title: [Mechanism of action, indications and abuse of benzodiazepine anxiolytic drugs].
abstract: Anxiolytic benzodiazepines are used in the treatment of anxiety. Nonmedical use has widely developed, mainly because of their ability to generate addiction. Main indications are anxiety disorders with or without depressive symptoms. Action mechanisms include complex interaction with GABA-receptor. Dependence, tolerance and withdrawal are well-known. Treatment of substance abuse is given. Main non-benzodiazepine alternate treatments of anxiety disorders are proposed.
authors.affiliation: Service de Psychiatrie de l'UCL, Université Catholique de Louvain, Bruxelles.
authors.forename: S
authors.initials: S
authors.lastname: Goffinet
mesh_terms: D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D019966:Substance-Related Disorders / Q000209:etiology* / Q000503:physiopathology / Q000534:rehabilitation
chemical_list: D014151:Anti-Anxiety Agents; D018377:Neurotransmitter Agents; D011963:Receptors, GABA-A
vernacular_title: Mécanisme d'action, indications et abus des benzodiazépines anxiolytiques.