An improved DNA-based identification of fetuses at risk for HPA-1a (PlA1) neonatal alloimmune thrombocytopenia.
A simple and reliable procedure, based on DNA amplification and HpaII mapping, is proposed for the identification of fetuses at risk for HPA-1a (PlA1) neonatal alloimmune thrombocytopenia which could cause life-threatening haemorrhage, even in early fetal life. This typing procedure for HPA-1 alleles should help in deciding, very early, the therapeutic management of the fetuses at risk.
Clemenceau
S
S
Institut National de Transfusion Sanguine, Paris, France.
Perichon
B
B
Elion
J
J
Kaplan
C
C
Krishnamoorthy
R
R
D016824:Antigens, Human Platelet / Q000032:analysis*; D001483:Base Sequence; D001792:Blood Platelets / Q000276:immunology*; D004247:DNA / Q000737:chemistry; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D039661:Integrin beta3; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods*; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000235:genetics
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D004247:DNA