DNA-binding domains: targets for viral and cellular regulators.
Specific DNA binding by eukaryotic transcription factors is conferred by several types of sequence motif. These domains have been extensively studied with regard to their precise interaction with DNA and the basis of sequence specificity. Evidence is accumulating that DNA-binding domains serve functions in addition to binding DNA: they are also targets of viral and cellular regulatory proteins.
Wagner
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Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605.
Green
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MR
D000818:Animals; D004247:DNA / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D015967:Gene Expression Regulation, Viral / Q000235:genetics / Q000502:physiology*; D005809:Genes, Regulator; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic
D004279:DNA, Viral; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D004247:DNA