Haemopoietic stem/progenitor cell transplant in Fanconi anaemia using HLA-matched sibling umbilical cord blood cells.
There have only been a few reports documenting the use of umbilical cord blood as a source of stem cells for haemopoietic reconstitution. We report our experience with a child with Fanconi anaemia (FA) who underwent a stem cell transplant using umbilical cord blood cells from his HLA matched sibling. Although the engraftment was somewhat slow, it was complete and comparable to other transplants performed in FA patients using HLA matched sibling marrow. There was no graft-versus-host disease. The post-transplant period was uncomplicated and, at a follow-up of 36 months, this child is well with normal blood counts and immune function.
Kohli-Kumar
M
M
Division of Pediatric Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-2899.
Shahidi
N T
NT
Broxmeyer
H E
HE
Masterson
M
M
Delaat
C
C
Sambrano
J
J
Morris
C
C
Auerbach
A D
AD
Harris
R E
RE
D002675:Child, Preschool; D002873:Chromosome Fragility; D005199:Fanconi Anemia / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D005312:Fetal Blood / Q000166:cytology*; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000032:analysis*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male
D006680:HLA Antigens