title: [Celiac disease in adults revealed by sensory-motor neuropathy].
abstract: Central or peripheral nervous system complications are occasionally observed in adult patients with celiac disease. Several mechanisms have been proposed including vitamin deficiency, vascular inflammation and a direct effect of gluten intolerance. Typical nerve fiber damage due to demyelinization has been suggested. We observed a 65-year old woman with a right peroneal nerve palsy superimposed on a diffuse peripheral neuropathy who was found to have folic acid deficiency which in turn led to the diagnosis of adult celiac disease. Electrophysiological and histological studies demonstrated a predominantly demyelinating peripheral neuropathy which responded first to parenteral folic acid supplementation and second to a gluten-free diet. The mechanisms of peripheral nerve damage in adult celiac disease are briefly discussed and the possible role of folic acid deficiency is emphasized.
authors.affiliation: Service de Neurologie, CHRU de Caen.
authors.forename: F
authors.initials: F
authors.lastname: Viader
authors.forename: F
authors.initials: F
authors.lastname: Chapon
authors.forename: T
authors.initials: T
authors.lastname: Dao
authors.forename: Y
authors.initials: Y
authors.lastname: Rivrain
authors.forename: B
authors.initials: B
authors.lastname: Lechevalier
mesh_terms: D000368:Aged; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis; D003711:Demyelinating Diseases / Q000209:etiology; D004594:Electrophysiology; D005260:Female; D005494:Folic Acid Deficiency / Q000150:complications; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000209:etiology*
vernacular_title: Maladie coeliaque de l'adulte révélée par une neuropathie sensitivo-motrice.