[The characteristics of the immune and neuromediator homeostasis in patients with borderline neuropsychic disorders in chronic poisoning by higher fatty-series aliphatic amines].
The authors provide the data on the etiological role played by higher aliphatic amines of the fatty series in the development of borderline neuropsychic disorders. The dopamine system was shown to play the leading part in their genesis. Activation of that system goes in parallel with disorders in immune and neuromediator homeostasis. Leukopenia, lymphocytosis, inhibition of T system immunity, a rise of the B lymphocyte count, beta-lysine, expression, of acetylcholine, dopamine, noradrenaline, adrenaline, histamine, serotonin, GABA, opiate and benzodiazepine receptors by immunocompetent cells were revealed. It has been demonstrated that the changes in the count of rosette-forming cells immune to neuromediators reflect the disease development and can be used as objective criteria for the diagnosis and treatment policy for borderline neuropsychic disorders caused by higher aliphatic amines of the fatty series.
Iushkov
V V
VV
Iushkova
T A
TA
Uriupina
M D
MD
Sedinina
N S
NS
D000328:Adult; D000588:Amines / Q000506:poisoning*; D001883:Borderline Personality Disorder / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006706:Homeostasis / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D008297:Male; D018377:Neurotransmitter Agents / Q000097:blood*; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D011041:Poisoning / Q000097:blood / Q000209:etiology / Q000276:immunology; D017981:Receptors, Neurotransmitter / Q000032:analysis
D000588:Amines; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter
Kharakteristika immunnogo i neĭromediatornogo gomeostaza u bol'nykh s pogranichnymi nervno-psikhicheskimi rasstroĭstvami pri khronicheskoĭ intoksikatsii vysshimi alifaticheskimi aminami zhirnogo riada.