From crystals to enzymes: simple models of molecular recognition.
Structural models resulting from the x-ray crystal structure determination of small molecules are shown to be closely mimicking some of the protein structure and function features. Crystals of inclusion compounds, a special type of solid molecular associates, lend special support to such a view. They are inherently suited for such modelling purposes due to easily visible association and molecular recognition effects. It is envisaged that combination of the analysis of high-resolution small molecule crystallographic models and those of protein structures will yield to further fruitful analogies.
Czugler
M
M
Central Research Institute of Chemistry, Hungarian Academy of Sciences, Budapest.
D001665:Binding Sites; D003460:Crystallization; D004798:Enzymes / Q000737:chemistry*; D006860:Hydrogen Bonding; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D013381:Subtilisins / Q000737:chemistry
D004798:Enzymes; D013381:Subtilisins