Sulfasalazine induced lupus in rheumatoid arthritis.
We describe 2 cases of a lupus syndrome induced by sulfasalazine in rheumatoid arthritis. All symptoms resolved and antihistone antibodies disappeared when sulfasalazine was discontinued. In one patient, perinuclear antineutrophil cytoplasmic antibodies with specificity for myeloperoxidase were found critically increased just before the occurrence of vasculitis.
Caulier
M
M
Service de Rhumatologie, CHU Purpan, Toulouse, France.
Dromer
C
C
Andrieu
V
V
Le Guennec
P
P
Fournie
B
B
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear / Q000097:blood; D000918:Antibody Specificity; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology; D012460:Sulfasalazine / Q000009:adverse effects*; D013577:Syndrome
D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D012460:Sulfasalazine; D009195:Peroxidase