title: Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice.
abstract: Persistent infection was established in SCID mice given 10(7) Cryptosporidium parvum oocysts. Nine groups of infected SCID mice were inoculated with 10(6), 10(5), or 10(4) total spleen cells, CD8-depleted spleen cells, or CD4-depleted spleen cells from naive BALB/c donors. Infection was significantly reduced in all treatment groups. The most profound effect occurred with spleen cell preparations containing CD4 T lymphocytes but depleted of CD8 T lymphocytes.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
authors.forename: L E
authors.initials: LE
authors.lastname: Perryman
authors.forename: P H
authors.initials: PH
authors.lastname: Mason
authors.forename: C E
authors.initials: CE
authors.lastname: Chrisp
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D016827:CD8 Antigens / Q000032:analysis; D003457:Cryptosporidiosis / Q000276:immunology*; D016785:Cryptosporidium parvum; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology* / Q000637:transplantation
chemical_list: D016827:CD8 Antigens