title: Hyperaemia in rat neocortex produced by acute exposure to methylenedioxymethamphetamine.
abstract: Cerebral blood flow and glucose utilization were measured in rat neocortex, hippocampus and striatum following methylenedioxymethamphetamine injection (5 mg/kg, i.v.), using the tracers [14C]iodoantipyrine and [14C]2-deoxyglucose, respectively. In control rats, blood flow was coupled to glucose metabolism, but in methylenedioxymethamphetamine-treated rats, marked hyperperfusion was measured in frontal and parietal cortex with no change in glucose use. This suggests that methylenedioxymethamphetamine has the potential to disrupt cerebrovascular control.
authors.affiliation: Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Kelly
authors.forename: I M
authors.initials: IM
authors.lastname: Ritchie
authors.forename: M
authors.initials: M
authors.lastname: Sangra
authors.forename: M J
authors.initials: MJ
authors.lastname: Cursham
authors.forename: E M
authors.initials: EM
authors.lastname: Dickson
authors.forename: B
authors.initials: B
authors.lastname: Kelly
authors.forename: F P
authors.initials: FP
authors.lastname: Neilson
authors.forename: M J
authors.initials: MJ
authors.lastname: Reidy
authors.forename: M C
authors.initials: MC
authors.lastname: Stevens
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006940:Hyperemia / Q000139:chemically induced*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D005947:Glucose; D018817:N-Methyl-3,4-methylenedioxyamphetamine