Defective apoptosis due to Bcl-2 overexpression may explain why B-CLL cells accumulate in G0.
Gottardi
D
D
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Alfarano
A
A
De Leo
A M
AM
Stacchini
A
A
Bergui
L
L
Caligaris-Cappio
F
F
D017209:Apoptosis / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects / Q000473:pathology*; D015973:Gene Expression Regulation, Leukemic / Q000187:drug effects; D006801:Humans; D007399:Interphase; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000473:pathology*; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2; D014407:Tumor Cells, Cultured; D014740:Vidarabine / Q000031:analogs & derivatives / Q000494:pharmacology
D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D014740:Vidarabine; C024352:fludarabine