Suppression of peptide YY-induced hyperphagia by terbutaline.
Central administrations of neuropeptide Y and peptide YY (PYY) produce robust increases in food intake, and this response may be contingent upon the availability of insulin. In contrast, beta 2-adrenergic agonists decrease food intake, and this effect also appears to be dependent on circulating insulin. To investigate a possible interaction between PYY and beta 2-adrenergic function, rats were given systemic injections of terbutaline, a beta 2 agonist, at doses of 0, 5, 10, and 50 mg/kg prior to injections of 0.57 nmol PYY in the paraventricular nucleus of the hypothalamus. Terbutaline pretreatment significantly decreased feeding elicited by PYY in a dose-dependent fashion. This suggests that beta 2-adrenoreceptor activity is involved in PYY-induced feeding.
Hagan
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MM
Department of Psychology, University of Texas at El Paso 79968-0553.
Moss
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DE
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D005768:Gastrointestinal Hormones / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006963:Hyperphagia / Q000139:chemically induced / Q000517:prevention & control*; D007267:Injections; D010286:Paraventricular Hypothalamic Nucleus; D019894:Peptide YY; D010455:Peptides / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects / Q000502:physiology; D013726:Terbutaline / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D005768:Gastrointestinal Hormones; D010455:Peptides; D018343:Receptors, Adrenergic, beta-2; D019894:Peptide YY; D013726:Terbutaline