The perivascular connective matrix.
The functional properties of the perivascular matrix facilitate the movement, protection and the nutrition of the blood vessels. At the same time the matrix deliniates the vessels to the organs. Different vascular diseases of the vascular system implicate the perivascular matrix consisting of a network of structural and cellular connective tissue components. Impairment of its structural integrity predominantly occurs either from primary or secondary affections. Monospecific antibodies directed against different structural proteins enable detailed histomorphological examinations of the inflammatory tissue reaction in the perivascular space. Since myofibroblasts, fibrocytes, endothelial cells, and macrophages participate in tissue repair mechanisms, in vitro studies on the collagen synthesis may contribute to the understanding of the perivascular tissue reaction according to injury. The present report summarizes perivascular diseases and the in vitro synthesis of procollagen, collagen, and fibronectin of endothelial cells, fibroblasts, smooth muscle cells, and macrophages.
Voss
B
B
Professional Associations' Research Institute, University Clinic Bergmannsheil, Bochum, FRG.
Rauterberg
J
J
Müller
K M
KM
D000818:Animals; D001808:Blood Vessels / Q000033:anatomy & histology* / Q000737:chemistry / Q000473:pathology; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000737:chemistry* / Q000473:pathology*; D006801:Humans; D014652:Vascular Diseases / Q000473:pathology*