[Effect of microinjection of lidocaine and L-glutamate into the nucleus paragigantocellularis lateralis on the respiration and arterial blood pressure in the rat].
The experiments were carried out to study the effects of unilateral microinjection of lidocaine (Lid) and L-glutamate (L-glu) into the caudal part of the nucleus paragigantocellularis lateralis (PGCL) on the respiration and arterial blood pressure in the rat. Injection of Lid reduced the duration of expiration (Te), increased the respiratory frequency (RF), and decreased the peak amplitude of the electromyographic activity of the diaphragm and the mean arterial blood pressure (MBP). Injection of L-glu decreased the duration of inspiration (Ti) and Te and increased MBP. These results suggest that the caudal part of PGCL participates in the control of the duration, pattern, rhythm and depth of respiration and in the maintenance of normal arterial blood pressure.
Wang
W
W
Zheng
Y
Y
Xu
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D018698:Glutamic Acid / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D009474:Neurons / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration / Q000187:drug effects*
D018698:Glutamic Acid; D008012:Lidocaine