G proteins in lymphocyte signalling.
The guanine nucleotide binding proteins p21ras are activated by the T-cell antigen receptor and play a critical role in transducing signals from the T-cell receptor to the cell nucleus. The mechanism that couples the T-cell receptor to p21ras is the focus of many current studies, but is as yet unidentified.
Cantrell
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Imperial Cancer Research Fund, London, UK.
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D016283:Proto-Oncogene Proteins p21(ras) / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*
D011948:Receptors, Antigen, T-Cell; D019204:GTP-Binding Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)