Soluble intercellular adhesion molecule-1 (ICAM-1) in sera and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis.
ICAM-1 plays an important role in inflammatory diseases. To assess level of soluble ICAM-1 in the circulation and inflamed lesions, we measured levels of soluble ICAM-1 in the circulation and bronchoalveolar lavage fluid (BALF) of patients with idiopathic pulmonary fibrosis (IPF) and with pulmonary sarcoidosis (PS) and of healthy volunteers (HV), and we also analysed ICAM-1 expression of BALF cells in some patients and HV. IPF patients had significantly higher levels of circulating ICAM-1 than HV, while PS patients did not. By contrast, significantly increased levels of BALF soluble ICAM-1 were found in PS patients compared with those of HV, but not in IPF patients. There were no significant differences in the proportions of ICAM-1+ BALF lymphocytes in IPF patients, PS patients and HV, whereas significantly increased proportions of ICAM-1+ pulmonary alveolar macrophages were found in PS patients compared with those of HV, but not in IPF patients. There was a significant positive correlation of BALF soluble ICAM-1 levels to BALF lymphocyte proportions in PS patients. Although the source of BALF soluble ICAM-1 is unclear, BALF soluble ICAM-1 appears to reflect the grade of local activity of sarcoidosis. An interesting discrepancy between soluble ICAM-1 levels in the circulation and BALF was found in IPF patients, and this might be an important clue to an understanding of this disorder.
Shijubo
N
N
Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Imai
K
K
Shigehara
K
K
Honda
Y
Y
Koba
H
H
Tsujisaki
M
M
Hinoda
Y
Y
Yachi
A
A
Ohmichi
M
M
Hiraga
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000097:blood; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000378:metabolism*; D017565:Sarcoidosis, Pulmonary / Q000378:metabolism*; D012907:Smoking / Q000378:metabolism
D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1