title: An atypical myeloproliferative disorder with t(8;13) (p11;q12): a third case.
abstract: A 43-year-old male presented with a myeloproliferative disorder with prominent lymphadenopathy. Examination of the bone marrow showed almost complete replacement by a population of cells with an acquired chromosomal translocation t(8;13)(p11;q12). There are two other case reports describing a similar clinical syndrome with t(8;13)(p11;q12) as the sole chromosomal aberration in bone marrow cells, suggesting a role for this translocation in the pathogenesis of this myeloproliferative disorder.
authors.affiliation: LRF Centre for Adult Leukaemia, Royal Postgraduate Medical School, Hammersmith Hospital, London.
authors.forename: D
authors.initials: D
authors.lastname: Macdonald
authors.forename: S M
authors.initials: SM
authors.lastname: Sheerin
authors.forename: N C
authors.initials: NC
authors.lastname: Cross
authors.forename: A
authors.initials: A
authors.lastname: Spencer
authors.forename: J M
authors.initials: JM
authors.lastname: Goldman
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D002908:Chronic Disease; D006801:Humans; D008297:Male; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic