Synthesis of 2-methylaminobenzimidazole derivatives tested for antiinflammatory activity.
A series of 1-alkyl substituted 2-methylaminobenzimidazole derivatives was prepared and tested. Some of them were assayed orally in the rat for antiinflammatory and analgesic properties. The compounds did not exhibit any significant activity compared with reference drug levels.
Da Settimo
A
A
Dipartimento di Scienze Farmaceutiche, Università di Pisa, Pisa.
Marini
A M
AM
Bianucci
A M
AM
Primofiore
G
G
Da Settimo
F
F
Boldrini
E
E
D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012015:Reference Standards; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001562:Benzimidazoles