On the association of Poland anomaly and primary microcephaly.
In this report we describe a moderately mentally retarded female child with the association of Poland's anomaly and primary microcephaly with marked neuronal migration disturbances, cortical atrophy and white substance hypoplasia. This observation further supports the suggestion that the subclavian artery supply disruption sequence may be part of a broader event of interruption of the early embryonic blood supply also involving the cerebral arterial vessels.
Fryns
J P
JP
Centre for Human Genetics, University of Leuven, Belgium.
de Smet
L
L
D000328:Adult; D004622:Embryo, Mammalian; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000150:complications*; D008297:Male; D008831:Microcephaly / Q000150:complications*; D011045:Poland Syndrome / Q000175:diagnosis*; D012039:Regional Blood Flow; D013348:Subclavian Artery / Q000002:abnormalities