Familial polyarteritis nodosa.
Familial polyarteritis nodosa (PAN) is rare. We describe here two siblings who developed PAN 8 years apart. HLA typing showed that the affected family members shared a common haplotype with their unaffected mothers. Further study of the family history suggested the possibility of an inherited disorder of connective tissue predisposing to autoimmunity and aneurysm formation.
Mason
J C
JC
Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Cowie
M R
MR
Davies
K A
KA
Schofield
J B
JB
Cambridge
J
J
Jackson
J
J
So
A
A
Allard
S A
SA
Walport
M J
MJ
D000293:Adolescent; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D010488:Polyarteritis Nodosa / Q000235:genetics*