[Use of heparin in the early post-traumatic period in burns and hemorrhage].
Experiments on dogs (n = 86) revealed that a combined injury led to marked disorders in the hemostasis, manifesting by third-degree syndrome of disseminated intravascular coagulation which develops as early as at the height of injury. Infusion therapy, particularly making use of intravenous polygluquin, led to progress of chronological and structural hypocoagulation and hypofibrinogenemia. Heparin in a dose of 25 to 30 U/kg b.w. reduced the severity of hypocoagulation shifts, this manifesting by a shorter time of some coagulation tests and suppression of intravascular platelet aggregation. A manifest trend to normalization of plasma and platelet hemostasis was observed 3 h after the onset of infusion therapy. This trend was more manifest if intraosseous infusion of isotonic NaCl solution was used.
Kil'diushov
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D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000517:prevention & control; D001780:Blood Coagulation Tests; D002056:Burns / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000517:prevention & control; D004285:Dogs; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D013997:Time Factors
D006493:Heparin
Primenenie geparina v rannem posttravmaticheskom periode pri ozhoge i krovopotere.