title: Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.
abstract: Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.
authors.affiliation: Department of Haematology, Christie Hospital, Manchester.
authors.forename: M N
authors.initials: MN
authors.lastname: Narayanan
authors.forename: G R
authors.initials: GR
authors.lastname: Morgenstern
authors.forename: J C
authors.initials: JC
authors.lastname: Chang
authors.forename: C J
authors.initials: CJ
authors.lastname: Harrison
authors.forename: M
authors.initials: M
authors.lastname: Ranson
authors.forename: J H
authors.initials: JH
authors.lastname: Scarffe
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000235:genetics / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000139:chemically induced* / Q000235:genetics / Q000628:therapy; D011379:Prognosis; D014178:Translocation, Genetic