Once-daily administration of aminoglycosides.
OBJECTIVE
To provide an overview of the efficacy and adverse effects associated with once-daily administration of aminoglycosides.


METHODS
An extensive MEDLINE search and review of journals was conducted to identify information for this review.


RESULTS
Aminoglycosides alone or in combination with beta-lactams are commonly used for their activity against gram-negative microorganisms. Numerous studies have been performed comparing efficacy and toxicity of once-daily administration of aminoglycosides with multiple-daily dosing. Two studies have found a significant difference in clinical efficacy between once-daily and multiple-daily dosing of aminoglycosides. Several studies have observed a lower incidence of toxicity with once-daily than multiple-daily dosing, but others have found no difference.


CONCLUSIONS
Review of the literature suggests that once-daily administration of aminoglycosides may be as safe and effective as multiple-daily dosing regimens for the treatment of certain infections caused by gram-negative bacteria.
Bates
R D
RD
Ohio State University, Wexner Institute for Pediatric Research, Columbus.
Nahata
M C
MC
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004427:Ear Diseases / Q000139:chemically induced; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D051381:Rats
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents