title: Individual differences in biocompatibility responses to hemodialysis.
abstract: There are very few reports in the literature on individual differences in the response to dialysis treatment. We studied the influence of the individual patient, dialysis membrane quality, blood-flow (Qb) and surface area on leukocyte activation and complement generation (C3a) during 234 hemodialysis treatments using Cuprophan (CU), hemophane (HE) and polyamide (PA) dialyzers. The most common reaction was a decrease in leukocyte count and an increase in C3a after 15-minutes of treatment. Leukocyte overshoot by the end of dialysis was observed at high Qb for all three membranes but at low Qb only during CU treatments. The reaction patterns were influenced by the quality of the membrane, area and Qb. Analysis of each individual patient showed for a large number of treatments reaction patterns corresponding to those described in the literature. However, some patients reacted differently. In four patients (20%), the nadir in leukocyte count and maximum in C3a concentration was reached considerably later during CU-dialysis. Three patients were devoid of pronounced early leukocyte response but presented with the late overshoot during CU-dialysis. Three other patients reacted with an early drop in leukocyte count and a rapid increase in C3a generation during PA treatments but not during HE treatments. Three other patients reacted vice versa. A particular mode of dialysis treatment may thus be biocompatible for some patients but not necessarily for all. In the case biocompatibility is desired the individual response to the particular dialysis mode needs to be identified. The underlying mechanisms warrant further studies.
authors.affiliation: Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: N R
authors.initials: NR
authors.lastname: Skroeder
authors.forename: P
authors.initials: P
authors.lastname: Kjellstrand
authors.forename: B
authors.initials: B
authors.lastname: Holmquist
authors.forename: C M
authors.initials: CM
authors.lastname: Kjellstrand
authors.forename: S H
authors.initials: SH
authors.lastname: Jacobson
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001672:Biocompatible Materials; D001783:Blood Flow Velocity / Q000502:physiology; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D003167:Complement Activation / Q000502:physiology; D015926:Complement C3a / Q000378:metabolism*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009757:Nylons / Q000737:chemistry; D006435:Renal Dialysis
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D009757:Nylons; C054645:Hemophan; D015926:Complement C3a; D002482:Cellulose; C009865:cuprammonium cellulose