Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets.
1. The anti-aggregatory potency of a number of E-type PGs was compared in human and rabbit platelet-rich plasma (PRP) and washed platelets. The potency of 13,14-dihydro-PGE1 and 5,6-dihydro-PGE3 is significantly higher in human than in rabbit washed platelets, while the potency of 15-keto-13,14-dihydro-PGE1 is higher in rabbit. 2. The potency of PGEs in rabbit PRP is very similar to that of washed platelets, with the exception of 1a,1b-dihomo-PGE2, which is of a significantly lower potency in PRR. 3. In human, 5,6-trans-PGE2, PGE3, and 15-keto-13,14-dihydro-PGE1 are more potent in PRP than in washed platelets. 4. The results indicate that the potency of E-type PGs in human and rabbit platelets is different and plasma can essentially influence the anti-aggregatory effect of PGEs; plasma can either decrease or increase potency.
Kobzar
G
G
Institute of Chemistry, Estonian Academy of Sciences, Tallinn.
Mardla
V
V
Järving
I
I
Lõhmus
M
M
Vahemets
A
A
Samel
N
N
Lille
U
U
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits
D010975:Platelet Aggregation Inhibitors; D011458:Prostaglandins E; D000244:Adenosine Diphosphate; D011464:Epoprostenol