Adhesion receptors in lymphocyte activation.
The past several years have seen significant progress in understanding the role of T lymphocyte coreceptors in adhesion and activation. New insights have been gained in several areas: the avidity regulation of beta 1 and beta 2 integrins and their role in signal transduction; the regulation of CD8 avidity; the role of Lck in CD4 coreceptor activity; and the novel role for CD2 adhesion in the T cell antigen response.
Collins
T L
TL
Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston.
Kassner
P D
PD
Bierer
B E
BE
Burakoff
S J
SJ
D000818:Animals; D018801:CD2 Antigens / Q000502:physiology; D015704:CD4 Antigens / Q000502:physiology; D016827:CD8 Antigens / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008213:Lymphocyte Activation / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*
D018801:CD2 Antigens; D015704:CD4 Antigens; D016827:CD8 Antigens; D016023:Integrins