[Pharmacodynamics and clinical therapeutic effects of aerosol and injection of shuanghuanglian].
The results show that both aerosol and injection of shuanghuanglian can increase the activity of NK cells in peripheral blood of the human body as well as the ability of lymphocyte to produce alpha-interferon. Their broad-spectrum antiseptic and virus-inhibiting actions have also been confirmed. The absolute bioavailability of aerosol was 96.88% (baicalin) and 90.69% (chlorogeniacid). The significant response rate of aerosol and injection was 84% and 83% respectively. The total response rate was 92% and 93% respectively.
Xu
K J
KJ
Institute of Clinical Pharmacy and Pharmacology, Harbin Medical University.
Wang
Y H
YH
Hu
J R
JR
Wu
L H
LH
Sun
K X
KX
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D016898:Interferon-alpha / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010612:Pharyngitis / Q000188:drug therapy; D011024:Pneumonia, Viral / Q000188:drug therapy; D011817:Rabbits
D000336:Aerosols; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D016898:Interferon-alpha