title: Randomised trial of prevention of biliary stent occlusion by ursodeoxycholic acid plus norfloxacin.
abstract: Biliary stents are liable to clog. We investigated whether a choleretic plus an antibiotic could delay clogging. 20 consecutive patients with a malignant biliary stricture were randomised after endoscopic insertion of a polyethylene stent to receive ursodeoxycholic acid plus norfloxacin (13-15 mg/kg and 400 mg, daily) or conservative treatment. The drug combination was associated with: a longer median patency of first (49 vs 6 weeks) and all stents (38 vs 7 weeks); a prolonged median survival (67 vs 18 weeks); and a shorter mean hospital stay (0.2 vs 1.0 days per week of survival). Thus ursodeoxycholic acid plus norfloxacin may prevent stent clogging.
authors.affiliation: Hepatology Unit, University Hospital, Poitiers, France.
authors.forename: T
authors.initials: T
authors.lastname: Barrioz
authors.forename: P
authors.initials: P
authors.lastname: Ingrand
authors.forename: I
authors.initials: I
authors.lastname: Besson
authors.forename: V
authors.initials: V
authors.lastname: de Ledinghen
authors.forename: C
authors.initials: C
authors.lastname: Silvain
authors.forename: M
authors.initials: M
authors.lastname: Beauchant
mesh_terms: D000284:Administration, Oral; D001652:Bile Ducts; D002779:Cholestasis / Q000209:etiology / Q000601:surgery; D003251:Constriction, Pathologic; D004359:Drug Therapy, Combination; D006801:Humans; D009643:Norfloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D015607:Stents / Q000009:adverse effects; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D014580:Ursodeoxycholic Acid; D009643:Norfloxacin