title: Molecular epidemiological studies of human herpesvirus 6 in families.
abstract: The mode of transmission of human herpesvirus 6 (HHV-6) was investigated by molecular epidemiological techniques in four families. HHV-6 was isolated from the peripheral blood of seven infants with exanthem subitum, including siblings, and from the saliva of two mothers. These isolates were examined for genetic relatedness by means of restriction enzymes analysis of purified DNA. While the profiles of the digestion patterns differed among families, they were very similar in a particular family. These results may suggest that HHV-6 is transmitted primarily from mother to child.
authors.affiliation: Department of Virology, Osaka University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mukai
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Okuno
authors.forename: H
authors.initials: H
authors.lastname: Kosuge
authors.forename: K
authors.initials: K
authors.lastname: Yamanishi
mesh_terms: D000328:Adult; D002353:Carrier State / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis; D005077:Exanthema Subitum / Q000382:microbiology / Q000635:transmission*; D005260:Female; D016679:Genome, Viral; D006566:Herpesviridae Infections / Q000382:microbiology / Q000635:transmission*; D015654:Herpesvirus 6, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D009035:Mothers; D009679:Nuclear Family; D012150:Polymorphism, Restriction Fragment Length; D012463:Saliva / Q000382:microbiology; D014766:Viremia / Q000382:microbiology
chemical_list: D004279:DNA, Viral