[Use of liposomes in early treatment of experimental wounds].
A suspension of phosphatidylcholine-cholesterol liposomes was suggested for exerting an effect on the main developmental mechanisms of an early inflammatory process. A single subcutaneous injection of the preparation reduced considerably the degree of the development of a secondary wound necrosis through early preventive tissue hyperhydration, decrease of vascular disorders in the injured segment, and the presence of a marked regional lymph stimulating effect. With prevention of secondary necrosis the results of primary debridement of gunshot wounds, postponed for 3 days, were improved significantly.
Shraer
T I
TI
Shaposhnikov
Iu G
IuG
Kreĭnes
V M
VM
D000818:Animals; D002784:Cholesterol / Q000008:administration & dosage*; D004285:Dogs; D004337:Drug Carriers; D008081:Liposomes; D009336:Necrosis; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing; D014948:Wounds, Gunshot / Q000473:pathology / Q000628:therapy*
D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; D002784:Cholesterol
Primenenie liposom v rannem lechenii éksperimental'nykh ran.