Influence of carbamazepine on the dose-response relationship of vecuronium.
We have determined the cumulative dose-response relationship for vecuronium from the evoked compound electromyogram of the hypothenar muscles in eight patients who were receiving carbamazepine. The ED50, ED90 and ED95 were 29, 52 and 64 micrograms kg-1, respectively, and were significantly different (P < 0.05) from those of a control group (ED50, ED90 and ED95 21, 36 and 44 micrograms kg-1, respectively).
Whalley
D G
DG
Division of Anesthesiology, Cleveland Clinic Foundation, Ohio 44195.
Ebrahim
Z
Z
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D014673:Vecuronium Bromide / Q000008:administration & dosage*
D002220:Carbamazepine; D014673:Vecuronium Bromide