[Function of the calcium-binding protein p26 (recoverin) in bovine retinal rods].
The bovine retina rod cell protein with an apparent M(r) 26 kDa (p26 [1] or recoverin [2]) was suggested to be a calcium-sensitive regulator of photoreceptor guanylate cyclase. The data obtained show that highly purified p26 is not capable of restoring guanylate cyclase in washed ROS membranes up to the level of a ROS suspension. At the same time we found that a Ca(2+)-sensitive complex of p26 and a protein with apparent M(r) 67 kDa, presumably rhodopsin kinase, is present in the ROS extract. We suggest that rhodopsin kinase can be a functional target for p26 in retina rod cells.
Gorodovikova
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Filippov
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D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002417:Cattle; D002850:Chromatography, Gel; D005136:Eye Proteins; D051606:G-Protein-Coupled Receptor Kinase 1; D006162:Guanylate Cyclase / Q000378:metabolism; D051597:Hippocalcin; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; D011494:Protein Kinases / Q000378:metabolism; D051603:Recoverin; D017948:Retinal Rod Photoreceptor Cells / Q000201:enzymology / Q000378:metabolism*; D013379:Substrate Specificity
D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; D051603:Recoverin; D051597:Hippocalcin; D011494:Protein Kinases; D051606:G-Protein-Coupled Receptor Kinase 1; D006162:Guanylate Cyclase
Izuchenie funktsii kal'tsiĭsviazyvaiushchego belka p26 (rekoverina) v palochkakh setchatki byka.