Isolation and genomic analysis of human T lymphotropic virus type II from Ghana.
An HTLV-II was isolated from a Ghanaian female patient with ARC and anti-HTLV-II antibody by cocultivation of PBMC with Molt-4 cells. A part of the 5' LTR of this virus was sequenced. Sequence homology between this virus and the corresponding sequence of Mo, the prototype of HTLV-II, is 97.4%. Furthermore, this virus is a member of the HTLV-IIa group, which was proposed by Hall et al. This is the first report of an HTLV-II sequence from Africa confirmed not only by serological evidence, but also by genomic analysis. This finding will provide useful information for considering the spread of HTLV-II in the world and the evolution of the HTLV group.
Igarashi
T
T
Research Center for Immunodeficiency Viruses, Kyoto University, Japan.
Yamashita
M
M
Miura
T
T
Osei-Kwasi
M
M
Aysi
N K
NK
Shiraki
H
H
Kurimura
T
T
Hayami
M
M
D000328:Adult; D001483:Base Sequence; D015480:Deltaretrovirus Antibodies / Q000097:blood; D005260:Female; D016679:Genome, Viral; D005869:Ghana / Q000453:epidemiology; D015491:HTLV-II Infections / Q000453:epidemiology*; D015367:Human T-lymphotropic virus 2 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D015480:Deltaretrovirus Antibodies