Excitatory interactions between glutamate receptors and protein kinases.
One of the most active areas of neurobiology research concerns mechanisms involved in paradigms of synaptic plasticity. A popular model for cellular learning and memory is long term potentiation (LTP) in hippocampus. LTP requires postsynaptic influx of Ca2+ which triggers multiple biochemical pathways resulting in pre- and postsynaptic mechanisms enhancing long term synaptic efficiency. This article focuses on an acute postsynaptic mechanism that can enhance responsiveness of glutamate receptors. Evidence is presented that calcium/calmodulin-dependent protein kinase II, the major postsynaptic density protein at excitatory glutaminergic synapses, can phosphorylate glutamate receptors and enhance ion current flowing through them.
Soderling
T R
TR
Vollum Institute, Oregon Health Sciences University, Portland 97201.
Tan
S E
SE
McGlade-McCulloh
E
E
Yamamoto
H
H
Fukunaga
K
K
D000595:Amino Acid Sequence; D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology*; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000502:physiology; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D017774:Long-Term Potentiation; D008959:Models, Neurological; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000502:physiology; D016716:PC12 Cells / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017470:Receptors, Glutamate / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission
D005971:Glutamates; D009419:Nerve Tissue Proteins; D017470:Receptors, Glutamate; D018698:Glutamic Acid; D011494:Protein Kinases; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases