Genital human papillomavirus infections in Taiwan.
OBJECTIVE
Identification and typing of HPV infections in genital condyloma and normal cytological cervix.


METHODS
Cervical cells from 289 Pap cases with normal cytological findings were examined for HPV infection by slot blot hybridization. Fifteen condyloma biopsy specimens were studied by Southern blot hybridization.


RESULTS
Thirty-six cases (12.5%) with normal cervical cytology were HPV positive. The predominant HPV type in women with normal cytology is HPV-16. Risk factors for HPV infection in women with normal cytology depend on age and history of pregnancies. Twelve cases (80%) of condyloma contained HPV-6 or -11 sequences. The predominant HPV type in genital condyloma is HPV-11.


CONCLUSIONS
HPV detection in population-based screening programs for cervical neoplasia can be an important tool in identifying women who are at risk of developing dysplasia and cervical cancer.
Tsao
Y P
YP
Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, China.
Yang
K Y
KY
Han
C P
CP
Yin
C S
CS
Yang
Y F
YF
Chen
S L
SL
D000328:Adult; D015139:Blotting, Southern; D003218:Condylomata Acuminata / Q000453:epidemiology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology*; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D002577:Uterine Cervical Diseases / Q000453:epidemiology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology*; D014626:Vaginal Smears
D004279:DNA, Viral