title: Induction of heat shock protein 70 and glial fibrillary acidic protein in the postischemic gerbil hippocampus.
abstract: Immunohistochemical changes of heat shock protein 70 (HSP 70) and glial fibrillary acidic protein (GFAP) were investigated in the gerbil hippocampus 1 h-7 days after 10 min of cerebral ischemia. Transient cerebral ischemia caused HSP 70 expression in GFAP-positive astrocytes in a delayed fashion, as compared with a rapid induction in vulnerable neurons such as hilar neurons. The present results may offer clues to elucidate the mechanisms of ischemic neuronal damage.
authors.affiliation: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Araki
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: X H
authors.initials: XH
authors.lastname: Liu
authors.forename: K
authors.initials: K
authors.lastname: Kogure
authors.forename: Y
authors.initials: Y
authors.lastname: Itoyama
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D005849:Gerbillinae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006624:Hippocampus; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons
chemical_list: D005904:Glial Fibrillary Acidic Protein; D006360:Heat-Shock Proteins