title: CSF and plasma MHPG, and CSF MHPG index: pretreatment levels in diagnostic groups and response to somatic treatments.
abstract: The authors report a significant positive correlation between levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) in cerebrospinal fluid (CSF) and plasma in drug-free affective disorder patients (major depression, mania, and schizoaffective disorder), but not in schizophrenia. Recent kinetic studies on the relationship between plasma and CSF MHPG discourage the interpretation of independent CSF MHPG levels without correction for the diffusion of MHPG across the blood-brain barrier. The authors therefore examine pretreatment CSF and plasma MHPG levels, and the CSF MHPG index (CSF MHPG corrected for by using simultaneously obtained plasma MHPG according to the method of Kopin et al. [1983]). No significant differences were found in these pretreatment MHPG measures among the four diagnostic groups. Changes in these MHPG indices, and their correlations with behavioral rating scores, are also examined with respect to response to the four major somatic therapies (neuroleptics, lithium, antidepressants, and electroconvulsive therapy).
authors.affiliation: Department of Psychiatry, University of Illinois at Chicago.
authors.forename: R P
authors.initials: RP
authors.lastname: Sharma
authors.forename: J I
authors.initials: JI
authors.lastname: Javaid
authors.forename: K
authors.initials: K
authors.lastname: Faull
authors.forename: J M
authors.initials: JM
authors.lastname: Davis
authors.forename: P G
authors.initials: PG
authors.lastname: Janicak
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D003937:Diagnosis, Differential; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D009638:Norepinephrine / Q000378:metabolism; D011618:Psychotic Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D012559:Schizophrenia / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D008734:Methoxyhydroxyphenylglycol; D008094:Lithium; D009638:Norepinephrine