title: Coronary artery operation with support of the Hemopump cardiac assist system.
abstract: Five patients with one- or two-vessel disease had one to three bypass grafts using the Hemopump cardiac assist system instead of cardiopulmonary bypass to decompress the heart and as circulatory support. In addition, the short-acting beta-blocker esmolol was given as a bolus and stepwise titrated to make the heart flaccid and facilitate operation. All patients had a 24F Hemopump placed into the left ventricle. The patients were given 7,500 U of heparin. Average time on Hemopump support was 56 minutes. All patients went through the procedure uneventfully. Thirty minutes after pump removal all patients were back to baseline hemodynamic values. None of the patients needed blood transfusion. No postoperative renal impairment was seen. This method has great potential and could avoid the drawbacks associated with cardiopulmonary bypass and cardioplegic arrest. Careful evaluation in randomized studies is the next step.
authors.affiliation: Linköping Heart Center, University of Linköping, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Lönn
authors.forename: B
authors.initials: B
authors.lastname: Peterzén
authors.forename: H
authors.initials: H
authors.lastname: Granfeldt
authors.forename: H
authors.initials: H
authors.lastname: Casimir-Ahn
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000368:Aged; D016063:Blood Loss, Surgical; D001026:Coronary Artery Bypass; D005260:Female; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011412:Propanolamines / Q000008:administration & dosage
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol