title: [Survival of patients with zidovudine resistant HIV].
abstract: The survival of 35 patients with AIDS or advanced HIV infection on zidovudine treatment was related to the viral sensitivity to the drug and to the CD4+ cell count. Fourteen patients died, the survivors were followed up for an average of 804 days. In a univariate Cox model, survival was strongly related to log IC90 (p = 0.0003) and to the CD4+ count (p = 0.0002). In a bivariate model, log IC90 and the CD4+ count contributed to the prediction of survival (p = 0.12 and 0.06, respectively). Large studies of combination or alternation therapy with several anti-HIV-drugs should be given high priority.
authors.affiliation: Epidemiafdeling M, Rigshospitalet, København.
authors.forename: P C
authors.initials: PC
authors.lastname: Gøtzsche
authors.forename: C
authors.initials: C
authors.lastname: Nielsen
authors.forename: J
authors.initials: J
authors.lastname: Gerstoft
authors.forename: C M
authors.initials: CM
authors.lastname: Nielsen
authors.forename: B F
authors.initials: BF
authors.lastname: Vestergaard
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology / Q000401:mortality*; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015331:Cohort Studies; D004311:Double-Blind Method; D004352:Drug Resistance, Microbial; D006679:HIV Seropositivity / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D011379:Prognosis; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D015215:Zidovudine
vernacular_title: Patientoverlevelse ved zidovudinresistent HIV.