Ectopic ACTH secretion due to a bronchopulmonary carcinoid localized by somatostatin receptor scintigraphy.
We present the case of a 65-year-old woman with an adrenocorticotropic hormone (ACTH) secreting bronchopulmonary carcinoid. This patient showed the typical long history of Cushing's syndrome, including hypokaliemia, impaired glucose tolerance, high levels of ACTH and beta-endorphin, and coproduction of other peptides. At the onset of clinical symptoms in 1979 an adrenal adenoma was suspected, and left-sided adrenalectomy was performed. The symptoms soon recurred, and the diagnosis of ACTH-dependent Cushing's syndrome was made. As no ACTH-secreting tumor was found, the right adrenal was resected, and the patient was followed up regularly. Fourteen years later chest roentgenography and computed tomography revealed a para-aortic pulmonary lesion, which was suspicious for a bronchopulmonary carcinoid. ACTH and beta-endorphin were excessively, pancreatic polypeptide slightly elevated at that time. The final diagnosis was made using somatostatin receptor scintigraphy which confirmed the hormonal activity of the suspicious lesion; no additional focus was found. This method turned out to be not only a useful additional localization technique but also a promising tool for characterization and staging of a suspected ACTH-producing carcinoid. The tumor was resected curatively, and the diagnosis was confirmed histologically.
Iser
G
G
Medizinische Universitätsklinik und Poliklinik Tübingen, Germany.
Pfohl
M
M
Dörr
U
U
Weiss
E M
EM
Seif
F J
FJ
D000182:ACTH Syndrome, Ectopic / Q000209:etiology* / Q000378:metabolism; D000368:Aged; D001984:Bronchial Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D002276:Carcinoid Tumor / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000032:analysis*
D017481:Receptors, Somatostatin