[Mivazerol and other benzylimidazoles with alpha-2 adrenergic properties].
4-Benzyl-imidazole compounds derived from Salbutanol are evaluated for potential adrenergic activities. The prevalent property of a series of new bioisosteres of catecholamines either of the saligenol-(ucb LO61) or benzamide-(Mivazerol) type is a selective alpha-adrenergic agonism, at the presynaptic level. The present study stresses the structural features responsible for the alpha-2-agonistic property.
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Département de Recherche Chimique, R&D, UCB S.A. Secteur Pharmaceutique Chemin du Foriest, Belgique.
Geerts
J P
JP
Michel
P
P
Motte
G
G
Noyer
M
M
D000316:Adrenergic alpha-Agonists / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D006168:Guinea Pigs; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects*
D000316:Adrenergic alpha-Agonists; D001562:Benzimidazoles; D007093:Imidazoles; D018341:Receptors, Adrenergic, alpha-2; C087969:mivazerol
Mivazerol et autres benzylimidazoles á properiétés alpha-2 adrénergiques.