title: Successful treatment of transfusion-associated graft-versus-host disease.
abstract: We present an immunocompetent patient with transfusion-associated graft-versus-host disease (GVHD), in which chimaerism of peripheral blood lymphocytes was demonstrated by analysis of a highly polymorphic genome. The patient was treated successfully with anti-CD3 monoclonal antibody, OKT3 and cyclosporin A. Although it is undoubtedly important to prevent transfusion-associated GVHD by irradiation of cellular blood components, intensive therapy with OKT3 and cyclosporin A in the early phase of onset may be effective for treatment of this potentially fatal condition. The mechanism of the effectiveness of this treatment for transfusion-associated GVHD is discussed.
authors.affiliation: First Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yasukawa
authors.forename: F
authors.initials: F
authors.lastname: Shinozaki
authors.forename: T
authors.initials: T
authors.lastname: Hato
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: Y
authors.initials: Y
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Tamai
authors.forename: H
authors.initials: H
authors.lastname: Takamatsu
authors.forename: S
authors.initials: S
authors.lastname: Shiobara
authors.forename: K
authors.initials: K
authors.lastname: Yoshizaki
authors.forename: S
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001483:Base Sequence; D016572:Cyclosporine / Q000627:therapeutic use; D003602:Cytotoxicity, Immunologic; D004247:DNA / Q000235:genetics; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D016131:Lymphocyte Subsets; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D012867:Skin / Q000473:pathology; D065227:Transfusion Reaction; D018183:Transplantation Chimera / Q000235:genetics
chemical_list: D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D016572:Cyclosporine; D004247:DNA