Pancreatic secretion in man: effect of fasting, drugs, pancreatic enzymes, and somatostatin.
The inhibitory effect of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic-cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide, and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 micrograms bid given subcutaneously; increasing the dose up to 100 micrograms tid had no additional benefit. A stable pancreatic-cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.
Anand
B S
BS
Digestive Diseases Section, VA Medical Center, Houston, Texas.
Goodgame
R
R
Graham
D Y
DY
D000086:Acetazolamide / Q000494:pharmacology; D000328:Adult; D002927:Cimetidine / Q000494:pharmacology; D017577:Cutaneous Fistula / Q000503:physiopathology; D005215:Fasting / Q000502:physiology*; D006801:Humans; D008049:Lipase / Q000494:pharmacology; D008297:Male; D015282:Octreotide / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010185:Pancreatic Fistula / Q000503:physiopathology; D010194:Pancreatin / Q000494:pharmacology*; D011413:Propantheline / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D011413:Propantheline; D013004:Somatostatin; D002927:Cimetidine; D010194:Pancreatin; D014700:Verapamil; D008049:Lipase; D000086:Acetazolamide; D015282:Octreotide