Genome scanning methods.
Recently introduced methods can allow an entire genome to be scanned at one time for sequences linked to trait loci. Representational difference analysis and genomic mismatch scanning are designed, respectively, to isolate and map sequences that differ between genomes discordant for a trait, or that are identical between genomes concordant for a trait. Other methods allow the whole genome to be scanned for regions of increased or decreased copy number, or for differentially methylated sequences.
Brown
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Stanford University School of Medicine, Howard Hughes Medical Institute, California 94305-5428.
D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005784:Gene Amplification; D030342:Genetic Diseases, Inborn / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D005821:Genetic Techniques; D016678:Genome; D006801:Humans; D009693:Nucleic Acid Hybridization
D005819:Genetic Markers; D004247:DNA