title: Rapid resolution following chemotherapy of Broca's dysphasia due to recurrent anaplastic astrocytoma.
abstract: A middle-aged man re-presented with a Broca's aphasia due to a recurrent fronto-cingulate anaplastic astrocytoma. Although the language disturbance did not improve with dexamethasone therapy, within 4 weeks of treatment with procarbazine, CCNU and vincristine, the dysphasia had almost completely resolved. The anatomico-functional aspects and possible mechanisms of production and resolution of the aphasia are discussed. Assessment of dysphasias in patients undergoing intensive therapy for brain neoplasms is often neglected, but it can provide good objective information about the efficacy of therapy.
authors.affiliation: Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Cole
authors.forename: D E
authors.initials: DE
authors.lastname: Fraser
authors.forename: I R
authors.initials: IR
authors.lastname: Whittle
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001039:Aphasia, Broca / Q000188:drug therapy*; D001254:Astrocytoma / Q000188:drug therapy*; D017809:Fatal Outcome; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000187:drug effects; D006179:Gyrus Cinguli / Q000187:drug effects; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D009460:Neurologic Examination / Q000187:drug effects; D009483:Neuropsychological Tests; D011344:Procarbazine / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D014750:Vincristine; D008130:Lomustine