Intrauterine growth retardation and fetal transverse cerebellar diameter.
In 103 small-for-gestational age (SGA) fetuses, the transverse cerebellar diameter (TCD), abdominal circumference (AC), head circumference (HC), and femur length (FL) were measured and their ratios calculated. In addition, umbilical venous blood samples were obtained by cordocentesis for measurements of fetal blood pH and erythroblast count. Compared with the AC, HC, and FL, the TCD was relatively mildly reduced. However, in the 28 fetuses with TCD > 2 SDs (standard deviations) below the normal mean, the degrees of growth retardation, acidaemia, and erythroblastosis were more severe, and the incidence of perinatal death was higher than in the group with a normal sized TCD. Although in the group with TCD > 2 SDs below the normal mean the TCD/AC ratio was increased, in the most severely growth-retarded fetuses this ratio was usually within the normal range. Thus, in intrauterine growth retardation (IUGR), cerebellar size is reduced in proportion to the severity of the disease and therefore the TCD cannot be used to obtain reliable information on the gestational age of small fetuses and the TCD/AC ratio does not provide reliable information as to whether or not fetuses are growth-retarded.
Snijders
R J
RJ
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London, U.K.
De Courcy-Wheeler
R H
RH
Nicolaides
K H
KH
D000005:Abdomen / Q000196:embryology; D000886:Anthropometry; D002508:Cephalometry; D002531:Cerebellum / Q000196:embryology* / Q000473:pathology; D005260:Female; D005269:Femur / Q000196:embryology; D005317:Fetal Growth Retardation / Q000196:embryology* / Q000209:etiology / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D010927:Placental Insufficiency / Q000150:complications; D011247:Pregnancy; D016216:Ultrasonography, Prenatal