title: [High Molecular Weight Urokinase Reference Standard (Control 901) of National Institute of Health Sciences].
abstract: A candidate for "High Molecular Weight Urokinase Reference Standard (HMW-UK RS, Control 901)" of the National Institute of Health Sciences (NIHS) was examined for evaluating the fibrinolytic activity. The urokinase activity of the candidate HMW-UK RS was determined by "two-stage method" as 800 Unit/Amp. against the present Urokinase Reference Standard (Control 881), through the collaborative study involving five laboratories. According to the gel-permeation chromatography of the candidate for the molecular determination, it was confirmed that more than 97% of the total urokinase activity was attributed to the higher molecular fraction, named HMW-UK. Thus it was authorized as the High Molecular Weight Urokinase Reference Standard of the NIHS.
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: C
authors.initials: C
authors.lastname: Yomota
authors.forename: M
authors.initials: M
authors.lastname: Murai
authors.forename: T
authors.initials: T
authors.lastname: Tanimoto
authors.forename: T
authors.initials: T
authors.lastname: Kimura
mesh_terms: D006077:Government Agencies; D006296:Health Services; D007564:Japan; D008970:Molecular Weight; D010602:Pharmacopoeias as Topic; D014568:Urokinase-Type Plasminogen Activator / Q000737:chemistry / Q000302:isolation & purification / Q000592:standards*
chemical_list: D014568:Urokinase-Type Plasminogen Activator