title: Single photon emission computed tomography (SPECT) measures of brain function in schizophrenia.
abstract: This study explores SPECT measured in schizophrenic patients at rest. Left temporal lobe activity was found to be decreased with increasing positive symptoms' scores scores. Medicated patients showed a reversal of this pattern underlying this positive symptom effect. Patients with a recent history of auditory hallucinations showed an atypical right temporal lobe dominance, which occurred independently of medication status. These preliminary data are suggestive of the potential utility of SPECT to elucidate symptom/medication/brain activity interrelationships in schizophrenia.
authors.affiliation: Department of Psychiatry, Sydney University, New South Wales.
authors.forename: E
authors.initials: E
authors.lastname: Gordon
authors.forename: R J
authors.initials: RJ
authors.lastname: Barry
authors.forename: J
authors.initials: J
authors.lastname: Anderson
authors.forename: R
authors.initials: R
authors.lastname: Fawdry
authors.forename: C
authors.initials: C
authors.lastname: Yong
authors.forename: S
authors.initials: S
authors.lastname: Grunewald
authors.forename: R A
authors.initials: RA
authors.lastname: Meares
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D014150:Antipsychotic Agents