Agonist-induced phosphatidylinositide breakdown and mitogenesis in retinal capillary pericytes.
We have examined the effects of a variety of vasoactive agents and growth factors on phosphatidylinositide turnover and DNA synthesis in cultured retinal capillary pericytes. A complex correlation between phosphatidylinositide turnover and DNA synthesis varied with different agonists. The resulting data indicate that phosphatidylinositide turnover is not the sole signaling pathway, and there must be multiple signaling pathways involved in pericyte mitogenesis.
Li
W
W
Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, People's Republic of China.
Tao
L
L
Yanoff
M
M
D000818:Animals; D002196:Capillaries / Q000166:cytology; D002455:Cell Division; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D006133:Growth Substances / Q000494:pharmacology*; D007295:Inositol Phosphates / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D012171:Retinal Vessels / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction
D006133:Growth Substances; D007295:Inositol Phosphates; D018377:Neurotransmitter Agents; D010716:Phosphatidylinositols; D004247:DNA