title: Transcription factors in early T-cell development.
abstract: Characterization of the transcription control regions for most genes encoding the TCR-CD3 complex has been followed by identification of DNA-binding factors, some of which are restricted to lymphoid or T-lineage cells. The sequential expression of these factors is linked with the appearance of stage-specific T-cell markers, thus controlling the commitment of the elusive lymphoid progenitor cell and its progression along the T-lineage. Here, Hans Clevers, Mariëtte Oosterwegel and Katia Georgopoulos discuss recent progress made in the recognition of transcription factors that regulate these early events in T-cell ontogeny.
authors.affiliation: Dept of Immunology, University Hospital, Utrecht, The Netherlands.
authors.forename: H C
authors.initials: HC
authors.lastname: Clevers
authors.forename: M A
authors.initials: MA
authors.lastname: Oosterwegel
authors.forename: K
authors.initials: K
authors.lastname: Georgopoulos
mesh_terms: D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology; D005801:Genes, Homeobox / Q000235:genetics / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology*; D016335:Zinc Fingers / Q000235:genetics / Q000276:immunology
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors