Induction and habituation of c-fos and zif/268 by acute and repeated stressors.
Acute restraint and shaking stress each induced the mRNA for the immediate early gene (IEG), c-fos, within 1 h in locus coeruleus (LC), midbrain raphe nuclei and central gray. Both acute restraint stress and acute shaking stress activated c-fos and zif/268 mRNA in paraventricular nuclei within 1 h. Midbrain A9 and A10 dopaminergic neurons did not show any c-fos or zif/268 mRNA induction by either acute stressor. Repeated restraint stress (14d, 1h/d) produced habituation to acute restraint stress, but not to acute shaking stress, in PVN, raphe and central gray. In LC, repeated restraint stress caused some habituation to both acute stressors.
Watanabe
Y
Y
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
Stone
E
E
McEwen
B S
BS
D000208:Acute Disease; D000818:Animals; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D051766:Early Growth Response Protein 1; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D016762:Genes, fos; D006185:Habituation, Psychophysiologic / Q000235:genetics*; D017874:Immediate-Early Proteins; D008125:Locus Coeruleus / Q000378:metabolism; D008297:Male; D009038:Motion; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D011903:Raphe Nuclei / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D012149:Restraint, Physical / Q000009:adverse effects; D013312:Stress, Physiological / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D017874:Immediate-Early Proteins; D009419:Nerve Tissue Proteins; D016760:Proto-Oncogene Proteins c-fos; D014157:Transcription Factors