title: Low levels of serum apolipoprotein A I and A II in senile dementia.
abstract: We studied the serum lipoprotein and apolipoprotein profiles in 44 patients with sporadic late-onset Alzheimer's dementia and 43 patients with vascular dementia. The levels of high-density lipoprotein (HDL) cholesterol were lower in both patient groups than in a control group. Apolipoprotein A I and A II levels have decreased in both the patient groups, especially in the vascular dementia group. The HDL-cholesterol levels correlated positively with the level of apolipoprotein A I, but not with the level of apolipoprotein A II. The ratios of apolipoprotein A I/A II have increased in both the patient groups. The apolipoprotein A II levels have disproportionally decreased in the patient groups. The serum apolipoprotein A II may involve the pathological process in the patients with senile dementia.
authors.affiliation: Third Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kuriyama
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Yamano
authors.forename: Y
authors.initials: Y
authors.lastname: Hokezu
authors.forename: S
authors.initials: S
authors.lastname: Togo
authors.forename: M
authors.initials: M
authors.lastname: Osame
authors.forename: T
authors.initials: T
authors.lastname: Igakura
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood; D001054:Apolipoproteins A / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003704:Dementia / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides