Homozygotes for the autosomal dominant neoplasia syndrome (MEN1).
Families in which both parents are heterozygotes for the same autosomal dominant neoplasia syndrome are extremely unusual. Recently, we had the unique opportunity to evaluate three symptomatic siblings from the union between two unrelated individuals affected by multiple endocrine neoplasia type 1 (MEN1). When the three siblings and their parents and relatives were genotyped for 12 markers tightly linked to the MEN1 locus, at 11q13, two of the siblings were found to be homozygotes, and one a heterozygote, for MEN1. With regard to the MEN1 syndrome, no phenotypic differences were observed between the two homozygotes and the heterozygotes. However, the two homozygotes showed unexplained infertility, which was not the case for any of the heterozygotes. Thus, MEN1 appears to be a disease with complete dominance, and the presence of two MEN1 alleles with mutations of the type that occur constitutionally may be insufficient for tumor development.
Brandi
M L
ML
Department of Clinical Physiopathology, University of Florence, Italy.
Weber
G
G
Svensson
A
A
Falchetti
A
A
Tonelli
F
F
Castello
R
R
Furlani
L
L
Scappaticci
S
S
Fraccaro
M
M
Larsson
C
C
D000306:Adrenal Cortex Neoplasms / Q000235:genetics; D000328:Adult; D000368:Aged; D002880:Chromosomes, Human, Pair 11; D005260:Female; D005799:Genes, Dominant; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D006934:Hypercalcemia / Q000235:genetics; D006961:Hyperparathyroidism / Q000235:genetics / Q000601:surgery; D006965:Hyperplasia; D007246:Infertility / Q000235:genetics; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics*; D010280:Parathyroid Glands / Q000473:pathology; D010375:Pedigree; D010911:Pituitary Neoplasms / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers