[Effects of long-term application of bunazosin hydrochloride eye drops on the aqueous flow rate and blood-aqueous barrier permiability in rabbit eyes].
We investigated the effects of long-term instillation of bunazosin hydrochloride--alpha 1 specific adrenergic antagonist--on the aqueous humor dynamics and blood-aqueous barrier in rabbit eyes. We examined intraocular pressure, aqueous flow rate, and blood-aqueous barrier permiability for albumin after four weeks application of 0.05% bunazosin. The effect of bunazosin on blood-aqueous barrier destruction by laser iridophotocoagulation was also examined. During four weeks, bunazosin reduced the intraocular pressure by 1.7 +/- 0.6 mmHg (mean +/- SEM). Continuous application of bunazosin had no significant influence on aqueous flow rate and fluorescein isothiocyanate-labeled rabbit albumin (FITC-Alb) concentration in the anterior chamber. Bunazosin had no effect on the rise of the FITC-Alb concentration after iris photocoagulation, but the intraocular pressure in bunazosin treated eyes was significantly lower than in control eyes one hour after photocoagulation.
Aihara
M
M
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Araie
M
M
Kaburaki
T
T
Shirato
S
S
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism*; D001769:Blood / Q000378:metabolism; D007429:Intraocular Pressure / Q000187:drug effects; D009883:Ophthalmic Solutions; D010539:Permeability / Q000187:drug effects; D011799:Quinazolines / Q000494:pharmacology*; D011817:Rabbits
D000317:Adrenergic alpha-Antagonists; D009883:Ophthalmic Solutions; D011799:Quinazolines; C018176:bunazosin