Bacterial adherence and mucosal cytokine production.
1. Uropathogenic E. coli adhere to mucosal sites. 2. In the urinary tract, adherence is followed by inflammation, including a mucosal cytokine response. 3. Bacteria activate epithelial cells to secrete IL-6 and IL-8. IL-6 may cause the fever and acute phase response that accompany systemic urinary tract infections. IL-8 may function as a neutrophil chemoattractant. 4. E. coli up-regulate adhesion molecule expression on epithelial cell lines and neutrophil migration through epithelial cell monolayers. This process is inhibited by antibodies to CD18 and ICAM-1. 5. Cytokines released by nonepithelial cells (T cells and monocytes) modify the epithelial cell cytokine response to bacteria.
Svanborg
C
C
Department of Medical Microbiology, Lund University, Sweden.
Agace
W
W
Hedges
S
S
Lindstedt
R
R
Svensson
M L
ML
D001422:Bacterial Adhesion; D002240:Carbohydrate Sequence; D016207:Cytokines / Q000378:metabolism; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000276:immunology*; D010861:Fimbriae, Bacterial / Q000378:metabolism; D006017:Glycolipids / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014552:Urinary Tract Infections / Q000276:immunology*
D016207:Cytokines; D006017:Glycolipids; D015850:Interleukin-6; D016209:Interleukin-8