Og4C3 circulating antigen, anti-Brugia malayi IgG and IgG4 titers in Wuchereria bancrofti infected patients, according to their parasitological status.
This study involved 221 microfilaremic (Mf+), 302 amicrofilaremic (Mf-) antigen positive (AG+) and 1454 Mf-antigen negative (AG-) individuals living in endemic villages. Whatever the group considered, antigen and antibody titers were widely distributed. Og4C3 antigen, detected both in Mf- and Mf+ patients, was significantly higher in Mf+ patients. The Mf parasitological status did not significantly influence the antifilarial antibodies levels in the infected AG+ individuals, although IgG4 was more discriminant. In the supposedly uninfected individuals (Mf-AG-), anti-filarial IgG and IgG4 could be detected in a large proportion of the group. Og4C3 circulating antigen test was confirmed to be a good marker of active Wuchereria bancrofti infection.
Chanteau
S
S
Institut de Recherces Médicales Louis Malardé, Papeete, Tahiti, French Polynesia.
Glaziou
P
P
Luquiaud
P
P
Plichart
C
C
Moulia-Pelat
J P
JP
Cartel
J L
JL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000097:blood*; D017178:Brugia malayi / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005368:Filariasis / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008842:Microfilariae; D008875:Middle Aged; D014958:Wuchereria bancrofti / Q000276:immunology*
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G