Production of tumour necrosis factors by human T cells stimulated by a superantigen, toxic shock syndrome toxin-1.
The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was much higher than that of CD8+ T cells in TSST-1-induced production of TNF-alpha and TNF-beta. The expression of MHC class II molecules on AC was required in the response.
Akatsuka
H
H
Department of Microbiology and Immunology, Tokyo Women's Medical College, Japan.
Imanishi
K
K
Inada
K
K
Yamashita
H
H
Yoshida
M
M
Uchiyama
T
T
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001427:Bacterial Toxins; D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D017931:DNA Primers / Q000235:genetics; D004768:Enterotoxins / Q000276:immunology*; D015804:HLA-DR4 Antigen / Q000235:genetics / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis / Q000235:genetics; D007739:L Cells; D008213:Lymphocyte Activation; D008233:Lymphotoxin-alpha / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D013211:Staphylococcus aureus / Q000276:immunology; D018089:Superantigens / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014162:Transfection; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000235:genetics
D001427:Bacterial Toxins; D017931:DNA Primers; D004768:Enterotoxins; D015804:HLA-DR4 Antigen; D007376:Interleukin-2; D008233:Lymphotoxin-alpha; D018089:Superantigens; D014409:Tumor Necrosis Factor-alpha; C030107:enterotoxin F, Staphylococcal