Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge.
The aim of the study was to investigate the effect of short-term treatment with fluticasone propionate on the response to nasal allergen challenge in patients with allergic rhinitis. Responses to nasal allergen challenge were assessed subjectively by recording symptom scores on visual analogue scales, and objectively by measuring histamine, PGD2 and LTC4 in nasal lavage and by measuring nasal inspiratory peak flow following challenge. Nasal allergen challenge resulted in an increase in all symptom scores (P < 0.05); an increase in histamine and PGD2 (P < 0.05), and a decrease in nasal inspiratory peak flow at 1 h, 5 h and 7 h following challenge (P < 0.05). The allergen-induced changes in symptom scores, mediator levels and nasal inspiratory peak flow were attenuated by treatment with fluticasone propionate (P < 0.05 for all parameters measured). Post-challenge nasal obstruction was decreased by 45%; sneezing, itching and rhinorrhoea by 73, 78 and 80% respectively in the group as a whole comparing scores whilst on fluticasone propionate with those on no therapy. Fluticasone propionate, 200 micrograms twice daily for 2 weeks is effective in reducing significantly the early and late response to nasal allergen challenge.
Scadding
G K
GK
Royal National Throat, Nose and Ear Hospital, London.
Darby
Y C
YC
Austin
C E
CE
D000281:Administration, Intranasal; D000328:Adult; D000485:Allergens / Q000009:adverse effects; D000730:Androstadienes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D000068298:Fluticasone; D005938:Glucocorticoids; D006632:Histamine / Q000378:metabolism; D006801:Humans; D007320:Inspiratory Capacity / Q000187:drug effects; D017997:Leukotriene C4 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D017817:Nasal Lavage Fluid / Q000737:chemistry; D006109:Poaceae; D011058:Pollen; D015230:Prostaglandin D2 / Q000378:metabolism; D011863:Radioimmunoassay; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
D000485:Allergens; D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D017997:Leukotriene C4; D006632:Histamine; D000068298:Fluticasone; D015230:Prostaglandin D2