A deficit in preprodynorphin mRNA expression in hippocampus of spontaneously hypertensive rats.
A significantly lower level of preprodynorphin mRNA hybridization signal was found in hippocampal dentate granule cells of spontaneously hypertensive rats at 4 and 16 weeks old, before and after hypertension development respectively, when compared with preprodynorphin (PPD) mRNA level in the hippocampus of age-matched Wistar-Kyoto rats. The possible implications of disturbed PPD mRNA and dynorphin expression in the hippocampus are discussed with regard to pathophysiology of hypertension and central control of cardiovascular function.
Wang
J Q
JQ
Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, NC 27858-4354.
Li
S
S
Ingenito
A J
AJ
McGinty
J F
JF
D000704:Analysis of Variance; D000818:Animals; D004399:Dynorphins / Q000096:biosynthesis*; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism; D011498:Protein Precursors / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011921:Rats, Inbred WKY / Q000378:metabolism; D012016:Reference Values
D011498:Protein Precursors; D012333:RNA, Messenger; C036448:pre-prodynorphin; D004399:Dynorphins