Neuronal expression of Fos protein in the paraventricular nucleus of the hypothalamus after i.p. injection of ulcergenic cinchophen.
The purpose of this study was to identify the CNS neurons that express Fos protein after i.p. injection of ulcergenic drug cinchophen (300 mg/kg). This was done in unanesthetized Wistar rats with careful physiological controls. The population of Fos-immunoreactive (Fos-ir) neurons was the largest in the medial parvicellular part of the paraventricular nucleus of the hypothalamus (PVH). Distribution of Fos-ir neurons in the PVH corresponds with that of the parvicellular neurons in the PVH which secrete corticotropin-releasing hormone (CRH). This study strongly suggests that the cinchophen-induced peptic ulcer may originate in excitation of the CRH-secreting neurons in the parvicellular part of the PVH.
Takayama
K
K
Department of Physiology 1st Division, Gunma University School of Medicine, Maebashi-shi, Japan.
Xiong
Y
Y
Miura
M
M
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000276:immunology; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced
D016760:Proto-Oncogene Proteins c-fos; D011804:Quinolines; D003346:Corticotropin-Releasing Hormone