title: Angioscopy in variant angina: coronary artery spasm and intimal injury.
abstract: Studies in pigs and dogs show that intimal injury is related to coronary artery spasm; it is not known whether intimal injury is related to coronary artery spasm in human beings. We examined intima at the site of coronary artery spasm by percutaneous transluminal coronary angioscopy in 10 of 13 consecutive patients with variant angina. Coronary artery spasms occurred spontaneously or were induced by intracoronary acetylcholine (10-100 micrograms). Angioscopy showed intimal injuries (haemorrhage, flap, thrombus, or ulcer) in 4 of the 10. We suggest that intimal injury is related to coronary artery spasm in human beings.
authors.affiliation: First Department of Internal Medicine, National Defense Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Etsuda
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
authors.forename: K
authors.initials: K
authors.lastname: Arakawa
authors.forename: K
authors.initials: K
authors.lastname: Satomura
authors.forename: T
authors.initials: T
authors.lastname: Shibuya
authors.forename: K
authors.initials: K
authors.lastname: Isojima
mesh_terms: D000109:Acetylcholine; D000788:Angina Pectoris, Variant / Q000473:pathology*; D017546:Angioscopy; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017539:Tunica Intima / Q000473:pathology*
chemical_list: D000109:Acetylcholine