Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection.
A 42-year-old Japanese man with chronic active Epstein-Barr virus (EBV) infection initially responded to treatment with interleukin-2 (IL-2). Six months later he developed thrombosis in the hepatic veins, and Budd-Chiari syndrome associated with severe hepatic damage was diagnosed. He also developed a solitary EBV-positive plasmacytoma in the right femur. Since these rare complications occurred after long-term IL-2 therapy, the possibility that long-term IL-2 therapy might cause Budd-Chiari syndrome and liver damage as well as EBV-associated plasmacytoma is discussed.
Nagafuchi
S
S
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ishibashi
H
H
Anzai
K
K
Ohshima
K
K
Ohno
Y
Y
Fukushima
N
N
Hashizume
M
M
Sugimachi
K
K
Chuman
H
H
Kikuchi
M
M
D000328:Adult; D006502:Budd-Chiari Syndrome / Q000139:chemically induced*; D002908:Chronic Disease; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D008297:Male; D010954:Plasmacytoma / Q000139:chemically induced* / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications*
D007376:Interleukin-2