title: Dixyrazine premedication for cataract surgery. A comparison with diazepam.
abstract: Peroral dixyrazine (15-30 mg, n = 50) and diazepam (4-10 mg, n = 50) were used as premedicants for geriatric patients having cataract surgery under regional block. Compared to the diazepam patients, a larger number of the dixyrazine medicated patients appeared anxious, and there was a statistically significant difference between the groups, when summing up changes in anxiety throughout the study period. The dixyrazine patients needed more frequent supplementation with intravenous sedative drugs, compared with their diazepam counterparts. Peroral dixyrazine is an applicable choice for calm patients, when only slight sedation, or avoidance of somnolence are required.
authors.affiliation: Department of Anaesthesia, Tampere University Hospital, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Oikkonen
authors.forename: H
authors.initials: H
authors.lastname: Heine
authors.forename: U
authors.initials: U
authors.lastname: Salminen
authors.forename: O
authors.initials: O
authors.lastname: Romppanen
authors.forename: P
authors.initials: P
authors.lastname: Inberg
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000698:Analgesia; D014150:Antipsychotic Agents / Q000008:administration & dosage; D001007:Anxiety / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D002387:Cataract Extraction; D003975:Diazepam; D004329:Droperidol / Q000008:administration & dosage; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009407:Nerve Block; D010149:Postoperative Pain / Q000517:prevention & control; D010640:Phenothiazines / Q000008:administration & dosage; D011229:Preanesthetic Medication; D016037:Single-Blind Method
chemical_list: D014150:Antipsychotic Agents; D010640:Phenothiazines; C012950:dixyrazine; D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl