Adenosine and somatostatin potentiate the alpha 1-adrenergic activation of phospholipase C in striatal astrocytes through a mechanism involving arachidonic acid and glutamate.
Marin
P
P
Chaire de Neuropharmacologie (INSERM U114), Collège de France, Paris.
Tencé
M
M
Delumeau
J C
JC
Glowinski
J
J
Prémont
J
J
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000378:metabolism*; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007295:Inositol Phosphates / Q000378:metabolism; D008959:Models, Neurological; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects / Q000502:physiology*; D015290:Second Messenger Systems; D013004:Somatostatin / Q000494:pharmacology*; D010738:Type C Phospholipases / Q000378:metabolism*
D005971:Glutamates; D007295:Inositol Phosphates; D018340:Receptors, Adrenergic, alpha-1; D016718:Arachidonic Acid; D018698:Glutamic Acid; D013004:Somatostatin; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D000241:Adenosine; D002118:Calcium