Quantification of adult cerebral hemodynamics by near-infrared spectroscopy.
Near-infrared spectroscopy was used to measure global cerebral blood flow and volume in 10 healthy adult volunteers. High- and low-cerebral blood flow compartments were detected with mean flows for all 10 subjects of 59 +/- 21 (SD) and 11 +/- 4 ml.100 g-1.min-1, respectively. The mean cerebral blood volume of the group was 2.85 +/- 0.97 ml/100 g. Analysis of spontaneous changes in the cerebral concentrations of oxyhemoglobin and deoxyhemoglobin demonstrated strong correlations between respiratory rate and the oscillation frequency of cerebral oxyhemoglobin concentration (r = 0.99) and arterial oxygen saturation (SaO2) (r = 0.99). An estimate of the mean cerebral oxygen saturation for all subjects averaged 59.4 +/- 12.4% when their mean SaO2 was 91.8 +/- 2.4% (equivalent to 67.6 +/- 13.8% at a normoxic SaO2 of 98%). These results demonstrate that near-infrared spectroscopy can be used as a noninvasive bedside technique for both qualitative and quantitative evaluation of cerebral hemodynamics and oxygenation in adults.
Elwell
C E
CE
Department of Medical Physics and Bioengineering, University College London, United Kingdom.
Cope
M
M
Edwards
A D
AD
Wyatt
J S
JS
Delpy
D T
DT
Reynolds
E O
EO
D000328:Adult; D001158:Arteries; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D006439:Hemodynamics; D006801:Humans; D007259:Infrared Rays; D008297:Male; D008955:Models, Cardiovascular; D008959:Models, Neurological; D010100:Oxygen / Q000097:blood
D010100:Oxygen