[A case of subacute thyroiditis with highly positive thyrotropin receptor antibodies and normal radioiodine uptake].
In this paper, we report on a 40-year-old female with subacute thyroiditis (SAT) who showed high levels of TSH-binding inhibitory immunoglobulins (TBII) and thyroid-stimulation blocking antibodies (TSBAb) from the early stage of the disease. Thyrotoxicosis continued for 2 months and it was subsequently followed by severe hypothyroidism. Levothyroxine was then started. At that time, both TBII and TSBAb were still positive, but they disappeared 6 months later and she remained euthyroid thereafter without treatment. When she was in a thyrotoxic phase and had a suppressed TSH level, her 24-hour radioiodine uptake was not suppressed (11%), and thyroid scan showed partial suppression of uptake in the right lobe. These observations indicate that the presence of TSH receptor antibodies (TRAb) may have modified the changes in thyroid state and the course of SAT.
Hisaoka
T
T
Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Momotani
N
N
Yoshimura
H
H
Ishikawa
N
N
Ito
K
K
Iino
S
S
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000378:metabolism; D013968:Thyroiditis, Subacute / Q000000981:diagnostic imaging / Q000276:immunology*
D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D007457:Iodine Radioisotopes