Somatostatin-14 increases the inositol-1,4,5-trisphosphate content in various areas of the brain.
The effects of somatostatin-14 on inositol-1,4,5-trisphosphate (IP3) content were examined in rat pituitary, hippocampus and cortex homogenates. Somatostatin increased IP3 concentration in all these investigated regions in a dose- and time-dependent manner. Maximal increase of IP3 content was found in the pituitary homogenate, and in the hippocampal and cortex homogenates the IP3 argumentation was slightly smaller. Time-response studies showed that this effect declined with extended time of incubation. These results suggest that IP3 is involved in the mechanism of action of somatostatin in brain.
Lachowicz
A
A
Department of Experimental Endocrinology and Hormone Research, Medical University of Lódź, Poland.
Pawlikowski
M
M
Ochedalski
T
T
D000704:Analysis of Variance; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013004:Somatostatin / Q000494:pharmacology*; D013997:Time Factors
D013004:Somatostatin; D015544:Inositol 1,4,5-Trisphosphate