[An attempt to use simplified mathematical analysis for evaluation of elimination of cyclobarbital from blood of acutely poisoned patients].
Two different mathematical methods were used to calculate the rate of poison elimination in 52 unconscious patients due to barbiturate poisoning. The process of poison elimination is reflected by an exponential curve. Its rate can be determined with the use of a logarithmic function formula. In the study, an attempt was made to find out whether a linear function formula could also be applied to calculate this parameter. The hypothesis was based on the observation that, when considered for short periods of time parts on an elimination curve resemble straight line. The barbiturate elimination was checked every four hours to ensure that the exponential curve be as close as possible to a straight line. Then, correlations between the rate of poison elimination calculated from both formulas and seven biochemical and clinical parameters of forced diuresis were examined. The findings revealed qualitative concordance of the results, i.e. correlations were found for the same parameters when the elimination rate was calculated either from the logarithmic or linear formula. For further verification of the hypothesis apart from a simple correlation analysis a normalized standard error (NSE) method was used to investigate these correlations. Also in this analysis a similar concordance of results was obtained: when there was a correlation between the elimination rate as a logarithmic function and particular parameter of forced diuresis, it was also found the same for the rate calculated from the linear function formula. Conversely the absence of correlation in the former case corresponded to similar absence in the latter.(ABSTRACT TRUNCATED AT 250 WORDS)
Kołaciński
Z
Z
Kliniki Ostrych Zatruć Instytutu Medycyny Pracy, Lodzi.
D001463:Barbiturates / Q000493:pharmacokinetics* / Q000506:poisoning*; D006801:Humans; D016014:Linear Models; D008954:Models, Biological
D001463:Barbiturates
Próba zastosowania uproszczonej analizy matematycznej do oceny zaniku cyklobarbitalu z krwi ostro zatrutych chorych.