[The prevention of surgical stress in lung cancer patients with the antioxidant dibunol].
Dibunol was administered 48 and 24 hours before the operation at a dose of 4 g using capsules of 1 g each, in lung cancer patients. Stress severity was judged from the blood content of hydrocortisone, 17-keto- and 17-ketogenic steroids in 24-h urine, the content of mid-molecular weight peptides and indicators of intoxication before the operation and at 1, 3 and 5-7 day following it. Stress-protective effect of dibunol was manifested by almost 2-fold reduction in the blood hydrocortisone, urine 17-KS and 17-KGS/24 h levels following the operation, and by return of these parameters to baseline level at day 3 (whilst without dibunal no normalization occurred even at day 5-7), as well as by an appreciable lowering of the parameters characterizing intoxication.
Baraboĭ
V A
VA
Bororov
L V
LV
Hunina
L M
LM
Maievs'ka
L P
LP
D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D007431:Intraoperative Complications / Q000378:metabolism / Q000517:prevention & control*; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000378:metabolism / Q000517:prevention & control*; D011292:Premedication; D013312:Stress, Physiological / Q000378:metabolism / Q000517:prevention & control*; D013997:Time Factors
D000975:Antioxidants; D002084:Butylated Hydroxytoluene
Profilaktyka operatsiĭnoho stresu u khvorykh na rak lehen' antyoksydantom dybunolom.