[The use of dynamic radiant thermometry in assessing the mechanism of action of drugs].
We studied the functional state of the kidneys, dynamic radiation heat losses from the lumbar area in 21 healthy subjects against the 1% water loading background and after the indometacin intake on 3 consecutive days, reckoned on the basis of 1 mg per 1 kg of body weight, at 25 mg 3 times/day. Administration of indometacin, even on short-term basis, was found to be associated with appreciable decrease in renal blood circulation, the result of this event being reduction of glomerular filtration and excretory function of the kidneys, and moderation in renal proteinuria. Dynamic radiation thermometry may be used in the assessment of the drug effect on renal haemodynamics and functional state of the kidneys. In patients with glomerulonephritis indometacin should not be prescribed.
Kaluhin
V A
VA
Proniaiev
V I
VI
Pishak
V P
VP
D001833:Body Temperature Regulation / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D012016:Reference Values; D013821:Thermometers; D013997:Time Factors; D014667:Vasopressins / Q000097:blood / Q000187:drug effects
D014667:Vasopressins; D007213:Indomethacin
Vykorystannia dynamichnoï radiatsiĭnoï teplometriï v otsintsi mekhanizmu diï likars'kykh zasobiv.