title: Quantification of adult cerebral hemodynamics by near-infrared spectroscopy.
abstract: Near-infrared spectroscopy was used to measure global cerebral blood flow and volume in 10 healthy adult volunteers. High- and low-cerebral blood flow compartments were detected with mean flows for all 10 subjects of 59 +/- 21 (SD) and 11 +/- 4 ml.100 g-1.min-1, respectively. The mean cerebral blood volume of the group was 2.85 +/- 0.97 ml/100 g. Analysis of spontaneous changes in the cerebral concentrations of oxyhemoglobin and deoxyhemoglobin demonstrated strong correlations between respiratory rate and the oscillation frequency of cerebral oxyhemoglobin concentration (r = 0.99) and arterial oxygen saturation (SaO2) (r = 0.99). An estimate of the mean cerebral oxygen saturation for all subjects averaged 59.4 +/- 12.4% when their mean SaO2 was 91.8 +/- 2.4% (equivalent to 67.6 +/- 13.8% at a normoxic SaO2 of 98%). These results demonstrate that near-infrared spectroscopy can be used as a noninvasive bedside technique for both qualitative and quantitative evaluation of cerebral hemodynamics and oxygenation in adults.
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, United Kingdom.
authors.forename: C E
authors.initials: CE
authors.lastname: Elwell
authors.forename: M
authors.initials: M
authors.lastname: Cope
authors.forename: A D
authors.initials: AD
authors.lastname: Edwards
authors.forename: J S
authors.initials: JS
authors.lastname: Wyatt
authors.forename: D T
authors.initials: DT
authors.lastname: Delpy
authors.forename: E O
authors.initials: EO
authors.lastname: Reynolds
mesh_terms: D000328:Adult; D001158:Arteries; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D006439:Hemodynamics; D006801:Humans; D007259:Infrared Rays; D008297:Male; D008955:Models, Cardiovascular; D008959:Models, Neurological; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen