Neuroanatomical characterization of a new mutant rat with dopamine depletion in the substantia nigra.
A new mutant rat strain with movement disorders has arisen spontaneously in a closed colony of Albino-Swiss rats at the Department of Anatomy, Glasgow University. The animals possess a progressive locomotor disorder which is first apparent at around post-natal day 10. We here report that tyrosine hydroxylase immunocytochemistry demonstrates that these mutants have profound depletions in dopaminergic systems in the substantia nigra and corresponding areas of neostriatum.
Clarke
D J
DJ
Department of Human Anatomy, University of Oxford, UK.
Payne
A P
AP
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002452:Cell Count; D004195:Disease Models, Animal; D004298:Dopamine / Q000096:biosynthesis / Q000172:deficiency*; D009069:Movement Disorders / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000032:analysis; D010300:Parkinson Disease; D051381:Rats; D011922:Rats, Mutant Strains / Q000033:anatomy & histology* / Q000235:genetics; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D009419:Nerve Tissue Proteins; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine