Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat.
The neuroprotective effects of remacemide hydrochloride ((+/-)-2-amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride) have been assessed with permanent occlusion of one middle cerebral artery in chloralose-anesthetized cats in which key physiologic variables have been monitored throughout the post-ischemic period. An infusion of remacemide hydrochloride (278 micrograms/kg/min; total dose 25 mg/kg) initiated 90 min prior to middle cerebral artery occlusion and discontinued at occlusion, reduced significantly (P < 0.02) the volume of ischemic damage (from 2505 +/- 454 mm3 of vehicle-treated cats to 1266 +/- 54 mm3 of remacemide hydrochloride-treated cats).
Bannan
P E
PE
Wellcome Surgical Institute, University of Glasgow, Scotland, UK.
Graham
D I
DI
Lees
K R
KR
McCulloch
J
J
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D002415:Cats; D002539:Cerebral Arterial Diseases / Q000188:drug therapy; D005260:Female; D002546:Ischemic Attack, Transient / Q000188:drug therapy*
D000081:Acetamides; D000927:Anticonvulsants; C067553:remacemide