title: Convergent pathways for steroid hormone- and neurotransmitter-induced rat sexual behavior.
abstract: Estrogen and progesterone modulate gene expression in rodents by activation of intracellular receptors in the hypothalamus, which regulate neuronal networks that control female sexual behavior. However, the neurotransmitter dopamine has been shown to activate certain steroid receptors in a ligand-independent manner. A dopamine receptor stimulant and a D1 receptor agonist, but not a D2 receptor agonist, mimicked the effects of progesterone in facilitating sexual behavior in female rats. The facilitory effect of the neurotransmitter was blocked by progesterone receptor antagonists, a D1 receptor antagonist, or antisense oligonucleotides to the progesterone receptor. The results suggest that in rodents neurotransmitters may regulate in vivo gene expression and behavior by means of cross-talk with steroid receptors in the brain.
authors.affiliation: Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.
authors.forename: S K
authors.initials: SK
authors.lastname: Mani
authors.forename: J M
authors.initials: JM
authors.lastname: Allen
authors.forename: J H
authors.initials: JH
authors.lastname: Clark
authors.forename: J D
authors.initials: JD
authors.lastname: Blaustein
authors.forename: B W
authors.initials: BW
authors.lastname: O'Malley
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001483:Base Sequence; D001552:Benzazepines / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D015259:Dopamine Agents / Q000008:administration & dosage / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D011187:Posture; D011374:Progesterone / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011980:Receptors, Progesterone / Q000235:genetics / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*
chemical_list: D001552:Benzazepines; D015259:Dopamine Agents; D016376:Oligonucleotides, Antisense; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol; C010452:estradiol-17 beta-benzoate; D004298:Dopamine