Synthesis of some new heterobicyclic compounds containing spiro-1,2,4-triazine moiety as potential anti HIV and anticancer agents.
A number of heterobicyclic compounds such as 1,3,5-thiazine, thiazolidinone, pyrimidine, pyrimidinedione, imidazole, quinazolinone and 1,2,4-triazinone derivatives have been synthesized by interaction of 1,6-dihydro-3 (2H)-thioxo-6-spiro-(9'-fluorene)-1,2,4-triazin-5(4H)-one (1) with sulphur/nitrogen compounds in neutral or alkaline medium. Structure elucidation of the new compounds has been carried out with the help of elemental analysis and spectral data. Some of these compounds were tested for in vitro anti HIV and anticancer activities.
Abdel-Rahman
R M
RM
Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt.
Seada
M
M
Fawzy
M
M
el-Baz
I
I
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006678:HIV / Q000187:drug effects*; D006801:Humans; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D013141:Spiro Compounds; D014227:Triazines