[Electron microscope observation on chronic vulvar dystrophy and vulvar carcinoma].
Nine cases of hyperplastic type, ten cases of lichen type, two cases of mixed type of chromic vulvar dystrophy and six cases of vulvar carcinoma were observed under electron microscope. Six cases of squamous carcinoma were moderately to highly differentiated under microscope, but they were cells of squamous carcinoma, adenocarcinoma, undifferentiated carcinoma, squamous-mucus carcinoma, squamous-melanin carcinoma, squamous-adenocarcinoma under electron microscope. All of the six cases consisted of several differentiated characteristic carcinoma cells similar to lung cancer. It indicated that vulvar carcinoma might originate from basal cells of squamous epithelia with polypotentiality differentiation. Infiltrating lymphocytes were encountered both among carcinoma cells and epithelial cells. Pseudopodia extensions of lymphocyte cell membranes were in contact with portions of carcinoma cell and epithelial membranes. Destroying membranes of carcinoma cells by lymphocytes was more serious than that of epithelial cells. The results of this study indicate that destroying carcinoma cells by lymphocytes is a part of immunity response of the body, but significance of lymphocytes present at epithelia remains to be studied.
Wang
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Y
Wang
J
J
Wang
S
S
Huang
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X
D002908:Chronic Disease; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008214:Lymphocytes / Q000648:ultrastructure; D014844:Vulva / Q000648:ultrastructure; D014845:Vulvar Diseases / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000648:ultrastructure*