title: Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report.
abstract: The effect on serum lipids of a flax seed supplement consisting of three slices of flax seed-containing bread and 15 g of ground flax seed was studied in 15 hyperlipemic subjects on long-term intake (800 IU/day) of vitamin E. The flax seed, which was high in alpha-linolenic acid and fiber, and which has been reported to lower serum cholesterol in elderly subjects, was provided in a 3-month feeding trial. Serum total and low-density lipoprotein cholesterol levels were reduced significantly; high-density lipoprotein cholesterol did not change during flax seed consumption. Thrombin-stimulated platelet aggregation decreased with the supplement. Serum lipid oxidation products decreased significantly during the washout period.
authors.affiliation: Kenneth L. Jordan Heart Fund, Montclair, New Jersey 07040.
authors.forename: M L
authors.initials: ML
authors.lastname: Bierenbaum
authors.forename: R
authors.initials: R
authors.lastname: Reichstein
authors.forename: T R
authors.initials: TR
authors.lastname: Watkins
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D001939:Bread; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004043:Dietary Fiber / Q000627:therapeutic use*; D002523:Edible Grain; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D012639:Seeds; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood / Q000627:therapeutic use; D017962:alpha-Linolenic Acid / Q000627:therapeutic use*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D017962:alpha-Linolenic Acid; D014810:Vitamin E; D000255:Adenosine Triphosphate