title: Mastectomy only versus radical mastectomy and postoperative radiotherapy in node negative, resectable breast cancer. A randomized trial.
abstract: Patients with clinically node negative resectable breast cancer were randomized to either mastectomy only or radical mastectomy and radiotherapy, and followed for 15-20 years. During follow-up axillary metastases occurred with the same frequency after mastectomy as was initially observed in the group that underwent axillary dissection. There was no significant survival difference between the two groups. When adjusting the treatment effect for differences in age, tumour size, lymph node metastases, and histology, the outcome after radical mastectomy plus irradiation was significantly inferior. Comedo carcinoma proved also in this study to carry a poor prognosis.
authors.affiliation: Department of Oncology, Malmö General Hospital, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Borgström
authors.forename: F
authors.initials: F
authors.lastname: Linell
authors.forename: L
authors.initials: L
authors.lastname: Tennvall-Nittby
authors.forename: J
authors.initials: J
authors.lastname: Ranstam
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011184:Postoperative Period; D018714:Radiotherapy, Adjuvant