title: Antipsychotic drugs: is more worse? A meta-analysis of the published randomized control trials.
abstract: Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.
authors.affiliation: Technology Assessment Group, Harvard School of Public Health, Boston, MA.
authors.forename: P
authors.initials: P
authors.lastname: Bollini
authors.forename: S
authors.initials: S
authors.lastname: Pampallona
authors.forename: M J
authors.initials: MJ
authors.lastname: Orza
authors.forename: M E
authors.initials: ME
authors.lastname: Adams
authors.forename: T C
authors.initials: TC
authors.lastname: Chalmers
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D006801:Humans; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D002746:Chlorpromazine