[Proliferating cell nuclear antigen/cyclin (PCNA/Cyclin) in thyroid carcinoma].
An immunohistochemical study of thyroid carcinoma using PC10, a monoclonal antibody against proliferating cell nuclear antigen (PCNA/Cyclin), was performed on paraffin sections. There was significant difference statistically in PCNA index between any two types of all four types of thyroid carcinoma (P < 0.01), with the index of 35.36 +/- 9.59 in papillary carcinoma, 184.60 +/- 7.08 in follicular carcinoma, 392.43 +/- 31.66 in medullary carcinoma, and 488.28 +/- 19.93 in undifferentiated carcinoma. The results indicate that PCNA/Cyclin detection is a reliable method to examine the fraction of proliferating cells of thyroid carcinoma on paraffin sections, and it could be used to determine the prognosis of thyroid carcinoma.
Xu
Y J
YJ
Hospital 309th of people's Liberation Army Beijing.
D018263:Adenocarcinoma, Follicular / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis*; D002277:Carcinoma / Q000276:immunology; D018276:Carcinoma, Medullary / Q000276:immunology; D002291:Carcinoma, Papillary / Q000276:immunology; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D009687:Nuclear Proteins / Q000032:analysis*; D018809:Proliferating Cell Nuclear Antigen; D013964:Thyroid Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen