title: Solubility of organic solutes in ethanol/water mixtures.
abstract: The log-linear solubilization model was applied to the experimental solubility data of 109 organic compounds in ethanol/water mixtures. It is found that the extent of solubilization strongly depends on the solute hydrophobicity and the ethanol concentration in the solvent mixture. Patterns of deviation from the log-linear model are related to the structure and hydrophobicity of the solutes. Predictive equations were obtained by regression of the experimental data with solute octanol/water partition coefficient (log Kow). The logarithms of the solubilization and the solute log Kow range over 11 orders of magnitude. The solubilities of chrysene, perylene, benzo[a]pyrene, pentachlorobenzene, and hexachlorobenzene in ethanol/water mixtures were experimentally determined, and the results fit well into the model.
authors.affiliation: Department of Pharmaceutical Practice, University of Arizona, Tucson 85721.
authors.forename: A
authors.initials: A
authors.lastname: Li
authors.forename: S H
authors.initials: SH
authors.lastname: Yalkowsky
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D000431:Ethanol / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry*; D007700:Kinetics; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D006838:Hydrocarbons; D014867:Water; D000431:Ethanol