Towards cloning the familial breast-ovarian cancer gene on chromosome 17.
The past year has seen a great deal of excitement in the field of breast cancer genetics. Since linkage of the familial breast-ovarian cancer gene (BRCA1) to chromosome 17, the critical region has been narrowed to 1.0-1.5 Mb by recombination studies, a detailed physical map has been constructed and much of the region has been cloned in yeast artificial chromosome, bacteriophage P1 and cosmid vectors. The focus now lies on identifying the genes housed within the BRCA1 region and scanning them for oncogenic mutations.
Brown
M A
MA
Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, UK.
Solomon
E
E
D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D003001:Cloning, Molecular; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D009857:Oncogenes; D010051:Ovarian Neoplasms / Q000235:genetics*