Changes in brain neurotransmitters in rodent malaria.
Changes in brain neurotransmitters [5-hydroxytryptamine (5-HT), norepinephrine, histamine and dopamine] were studied in Plasmodium berghei-infected mice and rats. 5-HT and norepinephrine contents of brain decreased significantly in Plasmodium berghei-infected mice and rats, but histamine and dopamine contents remained unaltered. Decreased 5-HT and norepinephrine contents of brain may play a role in cerebral vasodilatation in malaria.
Roy
S
S
Department of Physiology with Community Development, Vidyasagar University, Midnapore, India.
Chattopadhyay
R N
RN
Maitra
S K
SK
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006632:Histamine / Q000378:metabolism; D016779:Malaria, Cerebral / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010962:Plasmodium berghei; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism
D018377:Neurotransmitter Agents; D012701:Serotonin; D006632:Histamine; D004298:Dopamine; D009638:Norepinephrine