title: Protective effect of ternatin, a flavonoid isolated from Egletes viscosa less., in experimental liver injury.
abstract: The effect of ternatin, a tetramethoxyflavone from Egletes viscosa Less., on liver injury induced by carbon tetrachloride (CCl4) was investigated in rats. Twenty-four hours following CCl4 insult (2.5 ml/kg s.c.), changes in the serum enzymes, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase, as well as liver cell histology were used as indices of hepatic dysfunction. The results show that ternatin (30 mg/kg i.p. daily for 5 consecutive days) causes marked inhibition of CCl4-induced serum enzymes and morbid histologic changes. The observation suggests that ternatin possesses antihepatotoxic activity.
authors.affiliation: Department of Physiology, Federal University of Ceará, Fortaleza, Brazil.
authors.forename: V S
authors.initials: VS
authors.lastname: Rao
authors.forename: E G
authors.initials: EG
authors.lastname: Figueiredo
authors.forename: C L
authors.initials: CL
authors.lastname: Melo
authors.forename: G S
authors.initials: GS
authors.lastname: Viana
authors.forename: D B
authors.initials: DB
authors.lastname: Menezes
authors.forename: M S
authors.initials: MS
authors.lastname: Matos
authors.forename: E R
authors.initials: ER
authors.lastname: Silveira
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; C051080:ternatin (flavonoid); D002251:Carbon Tetrachloride; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase