Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.
Between June 1990 and April 1991, 62 colorectal tumors were assessed in a prospective fashion on the basis of various tumor characteristics. Parameters included K-ras mutation, overexpression of the p53 protein, and proliferating cell nuclear cell antigen, as well as standard histopathologic examination. A multivariate analysis showed that K-ras mutation correlated with vascular invasion (P < 0.01) and hematogenous metastasis (P < 0.01). With regard to survival time, multivariate analyses using the Cox proportional hazard model suggested that status of lymph node metastasis (P < 0.01, relative risk [rr] = 7.27), TNM stage (P < 0.05, rr = 5.37), lymphatic invasion (P < 0.05, rr = 4.48), and K-ras mutation (P < 0.06, rr = 3.69) are the most independent prognostic factors. We compared the prognostic value of the molecular assays and standard TNM prognostic factors by multivariate analysis.
Tanaka
M
M
First Department of Surgery, School of Medicine, Kanazawa University, Japan.
Omura
K
K
Watanabe
Y
Y
Oda
Y
Y
Nakanishi
I
I
D000236:Adenoma / Q000175:diagnosis; D000704:Analysis of Variance; D000951:Antigens, Neoplasm / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015999:Multivariate Analysis; D009154:Mutation; D009687:Nuclear Proteins / Q000032:analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D000951:Antigens, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53