Acute organophosphate poisoning after disulfoton ingestion.
A 75-year-old woman attempted suicide by ingesting a large quantity of granular Di-Syston which is an organophosphate insecticide containing 5% disulfoton (ethylthiometon). On admission, the total plasma phosphorodithioate sulfone concentration (disulfoton and its metabolites, phosphorodithioate sulfoxide and its sulfone) determined by gas chromatography was 1095 ng/mL. After gastric lavage, the concentration gradually decreased to 505 ng/mL. However, it began to increase again 20 h after admission and reached the peak concentration (1322 ng/mL) at 56 h. It was concluded that the secondary elevation of the plasma concentration was due to the prolonged absorption of the organophosphate from the residual granules in the stomach, despite the early gastric lavage. Pralidoxime iodide administration temporarily restored erythrocyte cholinesterase activity to almost normal and inhibited the excessive, delayed reduction of cholinesterase activity. It is recommended that poisoning with the granular form of disulfoton should be treated with repetitive or prolonged gastric and intestinal lavage, charcoal, and a continuous intravenous infusion of pralidoxime iodide in addition to atropine sulfate.
Futagami
K
K
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Otsubo
K
K
Nakao
Y
Y
Aoyama
T
T
Iimori
E
E
Urakami
S
S
Ide
M
M
Oishi
R
R
D000368:Aged; D002801:Cholinesterase Reactivators / Q000627:therapeutic use; D002802:Cholinesterases / Q000097:blood; D004222:Disulfoton / Q000378:metabolism* / Q000506:poisoning*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D013406:Suicide, Attempted; D013997:Time Factors
D002801:Cholinesterase Reactivators; D011220:Pralidoxime Compounds; D004222:Disulfoton; D002802:Cholinesterases; C028797:pralidoxime