Effect of leaf extract from Clerodendron colebrookianum on blood pressure in rats.
Hypotensive effect of the extract of leaves of C. colebrookianum was investigated. An extremely bitter fraction was isolated, which gave positive test for alkaloids. The fraction produced fall of blood pressure in a dose dependent manner. The fall of blood pressure was blocked by atropine. Hypertensive effects of adrenaline and noradrenaline were slightly antagonised by the alkaloidal extract.
Gupta
M
M
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Mazumder
U K
UK
Das
S
S
D000317:Adrenergic alpha-Antagonists / Q000302:isolation & purification / Q000494:pharmacology; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D004837:Epinephrine / Q000633:toxicity; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D007022:Hypotension / Q000139:chemically induced; D007194:India; D008297:Male; D009638:Norepinephrine / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000317:Adrenergic alpha-Antagonists; D000470:Alkaloids; D000959:Antihypertensive Agents; D010936:Plant Extracts; D001285:Atropine; D009638:Norepinephrine; D004837:Epinephrine