Porphyria cutanea tarda: pregnancy versus estrogen effect.
We describe the worsening of porphyria cutanea tarda in a young woman while she was taking oral contraceptives. However, she did not have an exacerbation during two pregnancies. We conclude that estrogens produced during pregnancy do not exert the same effect as orally administered medications that contain estrogen. The pronounced effect of oral ethinyl estradiol on the liver may be attributed to its first-pass effect on that organ.
Urbanek
R W
RW
Department of Medicine, Staten Island University Hospital, NY 10305.
Cohen
D J
DJ
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000378:metabolism; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects* / Q000378:metabolism; D004338:Drug Combinations; D004967:Estrogens / Q000096:biosynthesis / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008656:Mestranol / Q000009:adverse effects* / Q000378:metabolism; D009640:Norethindrone / Q000009:adverse effects* / Q000378:metabolism; D017119:Porphyria Cutanea Tarda / Q000139:chemically induced* / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*
D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D004967:Estrogens; C014715:Norinyl; D008656:Mestranol; D009640:Norethindrone