Inhaled tert-butyl acetate and its metabolite tert-butyl alcohol accumulate in the blood during exposure.
1. A continuous 5 h-exposure to approximately 440 ppm tert-butyl acetate in air (via a tracheal canule) resulted in continuously increasing concentrations of tert-butyl acetate and tert-butyl alcohol (metabolite of tert-butyl acetate) in the blood of rats. 2. This accumulation of tert-butyl acetate and tert-butyl alcohol was reproduced during a continuous exposure to about 900 ppm tert-butyl acetate in air over a period of 4 h and 15 min. After the inhalation approximately 50% of the blood level of tert-butyl acetate decreased within 45 min, but that of tert-butyl alcohol remained unchanged at a high level. 3. The accumulation of tert-butyl acetate and tert-butyl alcohol should be relevant for the health risk assessment at the workside.
Groth
G
G
Institute of Pharmacology and Toxicology, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany.
Freundt
K J
KJ
D000085:Acetates / Q000097:blood / Q000378:metabolism*; D000280:Administration, Inhalation; D000818:Animals; D000440:Butanols / Q000097:blood*; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents / Q000378:metabolism*; D020002:tert-Butyl Alcohol
D000085:Acetates; D000440:Butanols; D012997:Solvents; C089834:tert-butyl acetate; D020002:tert-Butyl Alcohol