Cerebral cortex beta-adrenoceptor binding in bipolar affective disorder.
Beta-Adrenoceptor density was measured in cerebral cortex membranes obtained postmortem from age-matched controls and subjects with bipolar disorder (BD). [125I]Iodopindolol (PIN) binding performed using a single point concentration was not different in frontal, occipital or temporal cortex in BD. Scatchard analysis of [125I]PIN binding in temporal cortex confirmed the lack of differences in binding density and no changes in KD between these two subject groups. These findings do not support alterations in the density or affinity of beta-adrenoceptor binding in cerebral cortex in BD.
Young
L T
LT
Section of Biochemical Psychiatry, Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
Li
P P
PP
Kish
S J
SJ
Warsh
J J
JJ
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D010869:Pindolol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013570:Synaptic Membranes / Q000473:pathology*; D009435:Synaptic Transmission / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; C029247:3-iodopindolol; D010869:Pindolol; D009638:Norepinephrine