title: Generation of activated protein C during thrombolysis.
abstract: The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 micrograms/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation--the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.
authors.affiliation: Scripps Research Institute, La Jolla, CA 92037.
authors.forename: A
authors.initials: A
authors.lastname: Gruber
authors.forename: A
authors.initials: A
authors.lastname: Pál
authors.forename: R G
authors.initials: RG
authors.lastname: Kiss
authors.forename: G
authors.initials: G
authors.lastname: Sas
authors.forename: J H
authors.initials: JH
authors.lastname: Griffin
mesh_terms: D000368:Aged; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D011486:Protein C / Q000032:analysis / Q000096:biosynthesis* / Q000378:metabolism; D018046:Protein C Inhibitor / Q000097:blood; D013300:Streptokinase / Q000494:pharmacology* / Q000627:therapeutic use; D015912:Thrombolytic Therapy
chemical_list: D011486:Protein C; D018046:Protein C Inhibitor; D013300:Streptokinase