HLA and atopic dermatitis with high serum IgE levels.
Patients with atopic dermatitis usually exhibit allergen-specific IgE antibodies against several environmental antigens. HLA restriction is presumed to be involved in the recognition of such antigens, but several previous reports have so far failed to find a significant association between atopic dermatitis and HLA antigens. In this study we examined 38 unrelated Japanese patients with severe atopic dermatitis and high serum IgE levels (greater than 800 U/ml). We investigated the serological HLA types and HLA class II alleles in this group of patients with atopic dermatitis. Frequencies of HLA-A24, A33, Cwblank, B44, DR13 and HLA-DRB1*1302, DQB1*0604, DPB1*0301 alleles were increased in the patients. In contrast, frequencies of HLA-Cw1, Bw6, DR4, DR53, and HLA-DQB1*0302 allele were decreased. However, none of these remained significant after p values were corrected. Further study on HLA association with atopic dermatitis through characterization of specific antigens or antigen epitopes is needed.
Saeki
H
H
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Kuwata
S
S
Nakagawa
H
H
Etoh
T
T
Yanagisawa
M
M
Miyamoto
M
M
Tokunaga
K
K
Juji
T
T
Shibata
Y
Y
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016009:Chi-Square Distribution; D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D006680:HLA Antigens; D006681:HLA-D Antigens; D007073:Immunoglobulin E