Abomasal and duodenal motility in yearling cattle after administration of prokinetic drugs.
Effects of the following treatments on abomasal and duodenal myoelectric activity in yearling cattle were studied: 2 ml of 0.9% sodium chloride solution (NACL); 0.07 mg of bethanechol (BET)/kg of body weight; 0.1 mg of metoclopramide (MET)/kg; and 0.07 mg of bethanechol and 0.1 mg of metoclopramide (BETMET)/kg. All treatments were administered SC during the early part of phase I of the migrating myoelectric complex. Myoelectric signals were recorded for 4 hours after administration of the treatments from 1 electrode in the antrum and 3 electrodes in the duodenum. For the antral spike rate (ASR), there was no significant difference among treatments during the first hour, but the ASR was significantly (P < 0.05) greater during hours 2 to 4 after treatment with BETMET, compared with ASR for MET alone. The duodenal spike rate (DSR) was significantly (P < 0.05) greater during the first hour after administration of BETMET than after the other treatments. After administration of BET, DSR was significantly (P < 0.05) greater than after MET or NACL. There was no difference in DSR after MET, compared with DSR after NACL. There was no significant difference in DSR among treatments during the second and third hours. The total antegrade propagating spike (TAPS) count was greater after administration of BETMET in all hours, compared with the other treatments. The ratio of TAPS to total spikes on the orad-most duodenal electrode was significantly (P < 0.05) greater after BETMET during hours 1 and 2.
Roussel
A J
AJ
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Brumbaugh
G W
GW
Waldron
R C
RC
Baird
A N
AN
D000018:Abomasum / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle; D004386:Duodenum / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D016065:Myoelectric Complex, Migrating / Q000187:drug effects / Q000502:physiology; D009919:Orchiectomy; D011706:Pyloric Antrum / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D001626:Bethanechol Compounds; D018723:Bethanechol; D008787:Metoclopramide