title: Nucleotide sequence of the cDNA encoding mouse thyroid peroxidase.
abstract: The nucleotide (nt) sequence of the cDNA encoding mouse thyroid peroxidase (TPO) has been determined. The TPO cDNA is 3281 nt long and its open reading frame encodes a protein composed of 914 amino acids (aa), including a putative initiation Met. The mouse TPO cDNA shows 75.3, 70.8, and 93.5% homology in the coding nt sequence with human, porcine, and rat TPO cDNAs, respectively. In the aa sequence, mouse TPO shows 73.4, 68.4, and 93.9% homology with human, porcine, and rat TPOs, respectively. Specifically, the aa sequence surrounding the proximal His residue, probably essential for TPO activity, is well conserved among these four organisms.
authors.affiliation: Department of Laboratory Medicine, Miyazaki Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kotani
authors.forename: K
authors.initials: K
authors.lastname: Umeki
authors.forename: I
authors.initials: I
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Takechi
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: S
authors.initials: S
authors.lastname: Ohtaki
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015723:Gene Library; D007453:Iodide Peroxidase / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: D007453:Iodide Peroxidase