title: A postmarketing surveillance study of zopiclone in insomnia.
abstract: Zopiclone, a novel cyclopyrrolone compound has recently become available for the treatment of insomnia in Singapore. Pharmacodynamic and pharmacokinetic studies have shown it to be an effective hypnotic with a good safety profile and minimal side-effects. The efficacy of Zopiclone was studied in a group of patients with insomnia (n = 40). The study group comprised patients with and without a psychiatric diagnosis. About two-thirds (65%) of the patients had been on hypnotics previously without relief of the insomnia. There was improvement in the various sleep parameters studied: sleep latency, sleep duration, night awakening, sleep quality, dreams, "day-after" effects. The drug was well-tolerated and only four patients experienced minor side-effects.
authors.affiliation: Institute of Mental Health/Woodbridge Hospital, Singapore.
authors.forename: R
authors.initials: R
authors.lastname: Mahendran
authors.forename: K T
authors.initials: KT
authors.lastname: Chee
authors.forename: L H
authors.initials: LH
authors.lastname: Peh
authors.forename: K E
authors.initials: KE
authors.lastname: Wong
authors.forename: L
authors.initials: L
authors.lastname: Lim
mesh_terms: D000328:Adult; D053961:Azabicyclo Compounds; D004325:Dreams / Q000187:drug effects; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders / Q000150:complications; D017060:Patient Satisfaction; D010879:Piperazines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011358:Product Surveillance, Postmarketing; D011618:Psychotic Disorders / Q000150:complications; D012846:Singapore; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D012894:Sleep Stages / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone