Repeated amphetamine evokes long-lasting depletion of thyrotropin-releasing hormone in the rat adrenal medulla.
Long-term amphetamine administration (5 mg/kg, ip, twice a day for 14 days) profoundly decreased the TRH level in the rat adrenal medulla at 2 h (by ca. 76%), 24 h (by ca. 51%) and 72 h (by ca. 48%) after the last drug injection. Single amphetamine (5 mg/kg ip) had no significant effect on the TRH level in that tissue, as measured at 2 h after the drug injection. Since TRH in the adrenal medulla is thought to exert a paracrine, inhibitory influence on the adrenal cortex, depletion of the peptide content may contribute to a persistent elevation of the plasma corticosterone level following repeated treatment with amphetamine.
Jaworska-Feil
L
L
Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Budziszewska
B
B
Lasoń
W
W
D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism; D000661:Amphetamine / Q000008:administration & dosage / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003429:Cross Reactions; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D011817:Rabbits; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
D013973:Thyrotropin-Releasing Hormone; D000661:Amphetamine; D003345:Corticosterone