A family pedigree exhibiting features of both multiple endocrine neoplasia type 1 and McCune-Albright syndromes.
The multiple endocrine neoplasia (MEN) type 1 and McCune-Albright syndromes share many clinical and biochemical characteristics. This report documents for the first time the occurrence and natural history of the McCune-Albright syndrome in a female with a strong family history of MEN type 1. There may be a functional link between both of these conditions, and there is a need to look for G-protein mutations as a mechanism for disease in MEN type 1.
O'Halloran
D J
DJ
Department of Endocrinology, Christie Hospital, Manchester, United Kingdom.
Shalet
S M
SM
D002648:Child; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications* / Q000235:genetics*; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000150:complications* / Q000235:genetics*; D010375:Pedigree