[Pharmacologic evaluation of p-hydroxyacetophenone derivatives as potential beta-adrenolytics].
The anti-isoprenaline and negative inotropic activity in the electrically stimulated guinea-pig left atria as well as the local anaesthetic activity of three 4-(2-hydroxy-3-isopropyl-aminopropoxy)-3-(alkoxymethyl) acetophenone derivatives were evaluated. The efficiency of the compounds was compared with the beta-adrenolytic drug atenolol. All of the compounds tested exhibited a statistically significant anti-isoprenaline activity, which increased from the propoxy- to heptyloxyderivative. However, the nonspecific cardiodepressive and local anaesthetic effects of the drugs increased in the same order: propoxy- < pentyloxy- < heptyloxyderivative.
Racanská
E
E
Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Kozlovský
J
J
D000098:Acetophenones / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects
D000098:Acetophenones; D000319:Adrenergic beta-Antagonists; C031335:4-hydroxyacetophenone
Farmakologické hodnotenie derivátov p-hydroxyacetofenónu ako potenciálnych beta-adrenolytík.