Frequency of human CYP2D6 mutant alleles in a normal Chinese population.
Substantial differences in the pharmacogenetics of debrisoquine hydroxylation exist between Caucasians and Chinese populations. Among Chinese, not only is the frequency of the poor metabolizer phenotype low, the contribution of the 29B mutation in the CYP2D6 gene is insignificant. By contrast the frequency of D6-J is very common (approximately 0.6) and is clearly related to the activity of debrisoquine hydroxylase. Its presence however, does not predict the poor metabolizer phenotype. The D6-C mutation was also not detectable in our population.
Lee
E J
EJ
Department of Pharmacology, National University of Singapore.
Jeyaseelan
K
K
D000328:Adult; D000483:Alleles; D002681:China; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009154:Mutation; D012016:Reference Values
D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6