title: Maternal and fetal outcome of pregnant women with idiopathic thrombocytopenic purpura: retrospective analysis of 25 pregnancies.
abstract: The optimal management of pregnant women with idiopathic thrombocytopenic purpura (ITP) is controversial. We reviewed our experience with 25 pregnancies in 19 women with ITP over a 14-year period. The incidences of bleeding during pregnancy and postpartum hemorrhage were 12.0% and 24.0%, respectively, in our series. No maternal mortality was noted. Thirteen infants were born by vaginal delivery and 12 by cesarean section. Moderate to severe neonatal thrombocytopenia (platelet count < 100 x 10(9)/L) was diagnosed in six newborns. One of them had intracranial hemorrhage complicated by a bilateral sensorineural hearing loss. ITP mothers with a prenatal platelet count < 30 x 10(9)/L and a platelet count < 100 x 10(9)/L at delivery had a higher risk of giving birth to infants with moderate to severe neonatal thrombocytopenia. Cesarean section may improve the outcome of these fetuses.
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, R.O.C.
authors.forename: H L
authors.initials: HL
authors.lastname: Hwa
authors.forename: R J
authors.initials: RJ
authors.lastname: Chen
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
authors.forename: T R
authors.initials: TR
authors.lastname: Wang
authors.forename: S C
authors.initials: SC
authors.lastname: Huang
authors.forename: S N
authors.initials: SN
authors.lastname: Chow
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011256:Pregnancy Outcome; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D012189:Retrospective Studies