Beta-blocker and calcium channel blocker toxicity.
Toxicity from beta-blocker and calcium channel blocker drugs is a challenging medical emergency with steadily increasing incidence. Clinical manifestations of intoxication with these drugs are presented in light of known pharmacologic and pharmacokinetic properties, as well as the physiology of the beta-adrenoreceptor and calcium channel. Review of clinical and basic science literature provides the basis for specific management guidelines for beta-blocker and calcium channel blocker toxicity.
Kerns
W
W
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina.
Kline
J
J
Ford
M D
MD
D000319:Adrenergic beta-Antagonists / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans
D000319:Adrenergic beta-Antagonists; D000931:Antidotes; D002121:Calcium Channel Blockers