The role of ornithine decarboxylase in c-Myc-induced apoptosis.
Translocations or amplifications which activate members of the myc gene family are common in human cancer. c-Myc is a central regulator of normal cell proliferation and differentiation (Luscher and Eisenman, 1991; Marcu et al. 1992) and can induce apoptosis (Askew et al. 1991, 1993; Evan et al. 1992; Bissonette et al. 1992; Shi et al. 1992). c-Myc is a transcription factor (Amati et al. 1992; Kretzner et al. 1992), however, the targets regulated by c-Myc which mediate its activities are not known. Here, we discuss the role of the ornithine decarboxylase (ODC) gene as a direct transcriptional target of c-Myc and demonstrate a role for ODC enzyme activity in c-Myc-induced apoptosis.
Packham
G
G
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105.
Cleveland
J L
JL
D000818:Animals; D017209:Apoptosis; D005786:Gene Expression Regulation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000201:enzymology; D007377:Interleukin-3 / Q000502:physiology; D051379:Mice; D009955:Ornithine Decarboxylase / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
D007377:Interleukin-3; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; D009955:Ornithine Decarboxylase