Tumor volume growth and cell proliferation in an estradiol resistant human endometrial adenocarcinoma growing in nude mice.
Ten human endometrial adenocarcinoma grafts were subsequently transplanted from an original tumour growing in nude mice for several years and nine were investigated for cell proliferation, tumour volume growth, allele imbalance and protein products of Rb and p53 suppressor genes to study a possible inherited connection between these factors. We did not find faster tumour volume growth in tumours with increased cell proliferation, in contrast to melanomas and breast cancers growing in nude mice. We concluded that a probably existing link between mechanisms regulating cell proliferation and cell loss in these two tumours does not operate in endometrial carcinoma as measured by us. The tumour progression may be one important factor which influences mechanisms regulating cell proliferation and cell loss.
Horvath
G
G
Division of Gynecological Oncology, Sahlgren's Hospital, Gothenburg, Sweden.
Andersson
H
H
Mellqvist
L
L
Leser
G
G
Delle
U
U
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004351:Drug Resistance; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000473:pathology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D016161:Genes, Retinoblastoma; D016158:Genes, p53; D006579:Heterozygote; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D016160:Retinoblastoma Protein / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53; D004958:Estradiol