Effects of mytilotoxin-contaminated mussels on leucinaminopeptidase and gamma-glutamyl transpeptidase activities in rat small intestine, kidney and liver.
An extract of mussels contaminated with Dinophysis was administered to rats 4 or 14 h before experimentation. The leucinaminopeptidase (LAP) and gamma-glutamyl transpeptidase (GGTP) activities were determined in samples of small intestine, kidney and liver. LAP activity decreased in the intestine 4 h after administration but returned to normal 14 h post-administration, and GGTP was unaffected. In the kidney brush border, 14 h after treatment, the levels of LAP in male samples and GGTP in both sexes, were increased. No alterations in hepatic enzymatic activity were detected.
Taboada
C
C
Department of Physiology, Faculty of Pharmacy, University of Santiago de Compostela, Spain.
Asuncoón Lamas
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M
D000818:Animals; D049872:Bivalvia / Q000469:parasitology*; D004141:Dinoflagellida; D005260:Female; D007421:Intestine, Small / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D007931:Leucyl Aminopeptidase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D008387:Marine Toxins / Q000633:toxicity*; D051379:Mice; D008871:Microvilli / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D008387:Marine Toxins; D005723:gamma-Glutamyltransferase; D007931:Leucyl Aminopeptidase