title: Thermogenesis after a mixed meal: role of leg and splanchnic tissues in men and women.
abstract: To determine the relative contribution of splanchnic and leg tissues to postprandial thermogenesis, systemic and regional oxygen consumption rates were measured in nine women and eight men before and for 6 h after the consumption of a mixed meal that provided one-third of the daily energy needs. In women, the increase in splanchnic oxygen uptake accounted for 63 +/- 12% of the postprandial increase in oxygen consumption, whereas in men it accounted for 35 +/- 14% (P = not significant between women and men). Leg oxygen uptake accounted for 11 +/- 4 and 10 +/- 3% of the increase in postprandial oxygen consumption in women and men, respectively. The combined data suggest that approximately 48% of postprandial thermogenesis over 6 h occurs in splanchnic tissues, whereas 30-35% occurs in skeletal muscle. Thus the increase in oxygen consumption after a mixed meal is primarily localized to splanchnic tissues, and major reductions in postprandial thermogenesis are unlikely to be attributable solely to abnormalities of skeletal muscle metabolism.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: M D
authors.initials: MD
authors.lastname: Jensen
authors.forename: C M
authors.initials: CM
authors.lastname: Johnson
authors.forename: P E
authors.initials: PE
authors.lastname: Cryer
authors.forename: M J
authors.initials: MJ
authors.lastname: Murray
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001833:Body Temperature Regulation; D004734:Energy Metabolism; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008643:Mesentery / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D013152:Splanchnic Circulation
chemical_list: D009638:Norepinephrine; D004837:Epinephrine