[Study on auto-solidified tumor vaccine].
In order to evaluate the immune effect of Auto-solidified tumor vaccine induced by thermal doses of 65 degrees C for 5 minutes on the killing and inactivation of cancer cells in operation, a series of experimental and clinical studies were carried out, the results showed that Balb/c mice immunized with ASTV could tolerate the aggression of H22 3 x 10(8) cancer cells with efficiency of 93.3% (28/30), the inoperable advanced hepatic cancer proved in operation was hypothermited and ASTV was made for immune injection postoperatively, with the clinical efficiency 76.8% (53/69), and 5-year survival rate 23% (9/39), the difference with control group is significant. In recent years, it is recognized once again that tumor can induce specific immunity. The most important matter is how to stimulate the host to produce effective cellular immunity. Our results showed that the thermal biological effect could inactivate cancer cell and change nuclear antigen in host net-like immunity system. Under gene regulation, the host can obtain the cellular immune effect against cancer cells.
Huan
J L
JL
Xinqiao Hospital, Third Military Medical College, Chongqing.
Xu
M G
MG
Huang
H
H
D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007111:Immunity, Cellular; D016233:Immunotherapy, Active; D008113:Liver Neoplasms / Q000276:immunology / Q000628:therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009368:Neoplasm Transplantation; D015164:Vaccines, Inactivated
D015164:Vaccines, Inactivated