title: Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane.
abstract: The activities of 1,2-dibromopropane (DBP) and 1,1,3-tribromopropane (TBP) were studied in seven genotoxicity assays, (i) SOS-induction in E. coli, (ii) DNA repair in primary rat hepatocyte culture, (iii) the Salmonella/microsome assay, (iv) a host-mediated assay using Salmonella, (v) the somatic mutation and recombination assay in Drosophila melanogaster, (vi) HGPRT-mutagenesis assay in ARL 18 cells, and (vii) micronucleus formation assay in mouse polychromatophylic erythrocytes (PCE), forestomach (FS), glandular stomach (GS), duodenum (D), jejunum (J), cecum (C) and liver (L). The halopropanes were also tested for tumor formation in the fish Danio rerio. DBP was active in assays (ii), (v), (vii FS) and (vii L). TBP was positive in assays (ii) and (iii), strongly positive in (vii L) and borderline positive in (iv). However, neither DBP nor TBP induced tumors in fish, in contrast to the carcinogenic 1,2-dibromo-3-chloropropane. The genotoxicity and potential carcinogenicity of DBP and TBP in mammals is discussed.
authors.affiliation: Cancer Research Center AMS Russia, Moscow.
authors.forename: G A
authors.initials: GA
authors.lastname: Belitsky
authors.forename: T A
authors.initials: TA
authors.lastname: Lytcheva
authors.forename: I A
authors.initials: IA
authors.lastname: Khitrovo
authors.forename: R D
authors.initials: RD
authors.lastname: Safaev
authors.forename: V S
authors.initials: VS
authors.lastname: Zhurkov
authors.forename: I F
authors.initials: IF
authors.lastname: Vyskubenko
authors.forename: L P
authors.initials: LP
authors.lastname: Sytshova
authors.forename: O G
authors.initials: OG
authors.lastname: Salamatova
authors.forename: E G
authors.initials: EG
authors.lastname: Feldt
authors.forename: V V
authors.initials: VV
authors.lastname: Khudoley
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D002478:Cells, Cultured; D004249:DNA Damage; D004260:DNA Repair; D005399:Fishes; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D013014:SOS Response, Genetics
chemical_list: D002273:Carcinogens; D009153:Mutagens; C092668:1,1,3-tribromopropane; C010440:dibromopropane; C007318:1,2-dibromo-3-chloropropane; D011407:Propane