Reduction of baroreceptor-related sympathetic discharge during NMDA receptor antagonism.
N-Methyl-D-aspartate receptor blockade by MK-801 produced changes in the baroreceptor related component of pre-ganglionic sympathetic discharges in kittens. Spectral analyses carried out on sympathetic and blood pressure signals demonstrated: (a) a marked reduction in amplitude of peaks, 2-6 Hz range, in sympathetic autopower spectra and (b) a substantial decrease of coherence between sympathetic and blood pressure signals in the 2-6 Hz range.
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Department of Pediatrics, Schneider Children's Hospital, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
Siddiqi
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ZA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004594:Electrophysiology; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology; D011311:Pressoreceptors / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate