[The psychopharmacotherapy of anxious-depressive states (the interrelationship of the structure of the comorbidity to the choice of drug therapy)].
The authors examined 65 inpatients aged 20-61 admitted to the clinic with obsessional-phobic and depressive conditions (comorbidity). According to DSM-III-R, the patients suffered from panic and major depressive disorders, dysthymia, atypical depression within schizoaffective disturbance. By the response of the patients to alprazolam (anxiolytic) and fluoketin (antidepressant) given by a special scheme, 3 types of comorbidity of obsessional-phobic and affective disturbances were recognized: 1) prevalent depression, 2) combination of dysthymia with marked obsessional-phobic disorders, 3) overcoming of obsessional-phobic and affective disorders. Type 1 and 2 patients benefited more from monotherapy with antidepressants or tranquilizers. Type 3 patients did well on combined chemotherapy with tranquilizers, antidepressants, neuroleptics.
Smulevich
A B
AB
Andriushchenko
A V
AV
Morkovkina
I V
IV
Tkhostov
A Sh
ASh
Koliutskaia
E V
EV
D000328:Adult; D000525:Alprazolam / Q000008:administration & dosage; D001007:Anxiety / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D003863:Depression / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D010698:Phobic Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D011599:Psychopathology; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D018709:Statistics, Nonparametric
D011619:Psychotropic Drugs; D005473:Fluoxetine; D000525:Alprazolam
Psikhofarmakoterapiia anksiozno-depressivnykh sostoianiĭ (vzaimosviaz' struktury komorbidnosti s vyborom medikamentoznoĭ terapii).