Advances in anti-inflammatory therapy.
Anti-inflammatory drugs are widely used in veterinary practice to provide symptomatic relief of acute and chronic inflammatory conditions. Whilst much is already known about the properties of corticosteroid and non-steroidal anti-inflammatory drugs, new findings on their biology and pharmacokinetics continue to emerge. These are discussed, together with some possible novel therapeutic applications. Recent evidence, suggesting that morphine-like analgesic drugs may possess anti-inflammatory activity, is additionally presented. Knowledge of the pathways of formation, actions and interactions of the diverse range of mediators responsible for the pathophysiological changes underlying the inflammatory process is also increasing. Compounds are being developed which act selectively to block the formation or actions of these mediators and the potential of such agents as anti-inflammatory drugs is discussed. Although such compounds do not, at present, have veterinary applications, when used either alone, or in combination, some may prove to be potent and effective therapeutic agents.
Cunningham
F M
FM
Department of Veterinary Basic Sciences, Royal Veterinary College, North Mymms, Hatfield, Hertfordshire.
Lees
P
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011982:Receptors, Prostaglandin / Q000187:drug effects; D017482:Receptors, Thromboxane / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists; D010972:Platelet Activating Factor; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane