Tamsulosin, a selective alpha 1-adrenoceptor antagonist, inhibits fertility of male rats.
This study examined the antifertility effects of tamsulosin, a highly potent and a selective, alpha 1-adrenoceptor antagonist, on male rats. The drug was administered subcutaneously as a single dose (0.15 mg kg-1). The drug caused a significant reduction in fertility (measured by number of uterine implants, quantal pregnancy, and fertility index). The antifertility effect was short lived and rapid in both onset (no later than 7 h of administration) and recovery (within 7 d). Libido and mating performance remained essentially uninhibited. On the other hand, the antifertility effect was accompanied by significant impairment in ejaculatory competence and enhancement of pre-implantation losses. Based on the results of this study and our previous studies it is concluded that alpha 1-adrenoceptor blockade has a potent antifertility effect in male rats.
Ratnasooriya
W D
WD
Department of Zoology, University of Colombo, Sri Lanka.
Wadsworth
R M
RM
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D011247:Pregnancy; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013449:Sulfonamides / Q000494:pharmacology*; D000077409:Tamsulosin
D000317:Adrenergic alpha-Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin