A search for associations between major histocompatibility complex restriction fragment length polymorphism bands and resistance to Haemonchus contortus infection in sheep.
Polymorphic bands were detected within the DQB and DRB regions of the ovine major histocompatibility complex by probing TaqI digested DNA from three large sheep half-sib families derived from a highly resistant ram. All animals were phenotypically assessed for Haemonchus contortus resistance by faecal egg counts and associations with RFLP bands and haplotypes were estimated using mixed model, best linear unbiased prediction statistical methods. Although the highly resistant sire was homozygous at the MHC, no significant associations were found between any band or haplotype and faecal egg count.
Blattman
A N
AN
Department of Animal Science, University of New England, Armidale, New South Wales, Australia.
Hulme
D J
DJ
Kinghorn
B P
BP
Woolaston
R R
RR
Gray
G D
GD
Beh
K J
KJ
D000818:Animals; D015139:Blotting, Southern; D005260:Female; D006188:Haemonchiasis / Q000235:genetics / Q000662:veterinary*; D006239:Haplotypes; D007113:Immunity, Innate / Q000235:genetics; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics / Q000276:immunology* / Q000469:parasitology