title: Nitrendipine and superoxide dismutase in ischemic renal injury.
abstract: The effect of the Ca entry blocker nitrendipine, the antioxidant superoxide dismutase (SOD), and a combination of nitrendipine and superoxide dismutase on postischemic renal function was studied in four groups (n = 24) of rats. The rats in group 1 (n = 6) were the ischemic control and received 10 mL of 0.9% NaCl. Group II (n = 6) received SOD 7.0 mg/kg. Group III (n = 6) received nitrendipine 1 mg/kg. Group IV (n = 6) received nitrendipine 1 mg/kg and SOD 7 mg/kg. After administration, both kidneys were rendered ischemic by cross-clamping the renal vessels for 60 min. Comparison of 24-h creatinine clearance (CCr) for 3 days after reversal of ischemia revealed: (a) nitrendipine alone was the most effective in preserving renal function (p < .05); (b) SOD provided some degree of improvement, but only on day 3 (p < .05); (c) a similar result was detected using a combination of nitrendipine and SOD (p < .05); (d) there was no significant difference between SOD and nitrendipine nor between SOD and the combination of nitrendipine/SOD; (e) there was a significant improvement with nitrendipine when compared to the combination of nitrendipine/SOD (p < .05).
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Loma Linda University, CA 92354.
authors.forename: W K
authors.initials: WK
authors.lastname: Jacobsen
authors.forename: R M
authors.initials: RM
authors.lastname: Schell
authors.forename: J S
authors.initials: JS
authors.lastname: Matsumura
authors.forename: D J
authors.initials: DJ
authors.lastname: Cole
authors.forename: G R
authors.initials: GR
authors.lastname: Stier
authors.forename: R D
authors.initials: RD
authors.lastname: Martin
authors.forename: B L
authors.initials: BL
authors.lastname: Fandrich
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000818:Animals; D003404:Creatinine / Q000097:blood / Q000652:urine; D004359:Drug Therapy, Combination; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D009568:Nitrendipine / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000627:therapeutic use*
chemical_list: D009568:Nitrendipine; D003404:Creatinine; D013482:Superoxide Dismutase