Effects of alpha- and beta-adrenergic antagonist on epinephrine-induced aggregation and intracellular free calcium concentration in human platelets.
Recently, it has been reported that an alpha-adrenergic antagonist phentolamine inhibits epinephrine-induced platelet aggregation but a beta-adrenergic antagonist propranolol did not. In this study, we examined the effects of alpha- and beta-adrenergic antagonist on cytosolic free calcium movements induced by epinephrine. An alpha-adrenergic antagonist phentolamine was found to inhibit the elevation of cytosolic free calcium concentration induced by epinephrine, while a beta-adrenergic antagonist propranolol had no effect on cytosolic free calcium concentration induced by epinephrine.
Kimura
Y
Y
2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Japan.
Okuda
H
H
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D003600:Cytosol / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology*; D005340:Fibrinogen / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010646:Phentolamine / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D005340:Fibrinogen; D012964:Sodium; D011433:Propranolol; D002118:Calcium; D004837:Epinephrine; D010646:Phentolamine