Chiral separation of diniconazole, uniconazole and structurally related compounds by cyclodextrin-modified micellar electrokinetic chromatography.
Enantiomeric separation of the structural analogs, diniconazole and uniconazole, can be achieved by cyclodextrin (CD)-modified micellar electrokinetic chromatography (MEKC). The elution behavior of other structurally related compounds was therefore investigated and compared with that in high-performance liquid chromatography (HPLC) using a CD-bonded stationary phase. From the results, it was concluded that the benzene ring of the solute plays an important role in formation of CD complexes and chiral recognition in MEKC as well as in HPLC, although the enantioselectivity with the two methods was different. Nuclear magnetic resonance (NMR) data revealed different CD effects on the solute between the MEKC and HPLC models.
Furuta
R
R
Environmental Health Science Laboratory, Sumitomo Chemical Company, Osaka, Japan.
Doi
T
T
D002845:Chromatography / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins; D004563:Electrochemistry; D004586:Electrophoresis / Q000379:methods*; D005659:Fungicides, Industrial / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D010937:Plant Growth Regulators / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry / Q000302:isolation & purification*
D003505:Cyclodextrins; D005659:Fungicides, Industrial; D008823:Micelles; D010937:Plant Growth Regulators; D014230:Triazoles; C092705:uniconazole; C049346:diniconazole