Distribution and control of coronary microvascular resistance.
Coronary blood flow depends upon the vascular resistance distributed non-uniformly within the coronary microcirculation. Coronary microvascular resistance is governed by metabolic, myogenic, endothelial and neurohumoral influences. A number of these control mechanisms interact locally within a microvascular segment. In addition, these control mechanisms occupy differing longitudinal response gradients, a feature which maximizes their potential for the synergistic control of flow.
Jones
C J
CJ
Department of Cardiology, University of Wales College of Medicine, Cardiff, UK.
Kuo
L
L
Davis
M J
MJ
Chilian
W M
WM
D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D008833:Microcirculation / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D018006:Myogenic Regulatory Factors / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology*
D018006:Myogenic Regulatory Factors; D018377:Neurotransmitter Agents