title: Adhesion receptors in lymphocyte activation.
abstract: The past several years have seen significant progress in understanding the role of T lymphocyte coreceptors in adhesion and activation. New insights have been gained in several areas: the avidity regulation of beta 1 and beta 2 integrins and their role in signal transduction; the regulation of CD8 avidity; the role of Lck in CD4 coreceptor activity; and the novel role for CD2 adhesion in the T cell antigen response.
authors.affiliation: Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston.
authors.forename: T L
authors.initials: TL
authors.lastname: Collins
authors.forename: P D
authors.initials: PD
authors.lastname: Kassner
authors.forename: B E
authors.initials: BE
authors.lastname: Bierer
authors.forename: S J
authors.initials: SJ
authors.lastname: Burakoff
mesh_terms: D000818:Animals; D018801:CD2 Antigens / Q000502:physiology; D015704:CD4 Antigens / Q000502:physiology; D016827:CD8 Antigens / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008213:Lymphocyte Activation / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D018801:CD2 Antigens; D015704:CD4 Antigens; D016827:CD8 Antigens; D016023:Integrins