[Excitant effect of suberogorgin on isolated guinea pig trachea].
Suberogorgin (Sub) was shown to increase the tension of isolated guinea pig trachea in a dose-dependent manner. Its ED50 was 52.5 mumol.L-1. The stimulation of sub on trachea was antagonized by atropine 0.65 mumol.L-1, and inhibited by atropine 0.13 mumol.L-1, cobrotoxin 2.4 micrograms.ml-1 and by tetrodotoxin 1 mumol.L-1. On the contracted trachea induced by galanthamine 35.5 mumol.L-1, acetylcholine increased the tension but Sub did not. Galanthamine was also shown not to increase the tension of trachea that had been treated with Sub 258 mumol.L-1 for 10 min. The results indicate that the trachea-excitant action of Sub is related to the M and N receptor and the Na+ channel.
Peng
W D
WD
Department of Biology, Zhongshan University, Guangzhou.
Xu
S B
SB
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005702:Galantamine / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; D005702:Galantamine; C049055:suberogorgin