[Inhibition of the protein kinase C-alpha gene overexpression in rat preneoplastic liver by selenium].
Effect of selenium on the protein kinase c-alpha (PKC-alpha) gene expression was observed in the preneoplastic lesions in liver of S.D. rat Solt-Farber model. Overexpression of PKC-alpha was found in preneoplastic liver but not in partially hepatectomized liver. Administration of 4PPm Na2SeO3 in water 2 weeks before i.p injection of DEN (200 ng/kg bw) for 8 weeks reduced the PKC-alpha gene overexpression in preneoplastic liver and the formation of hyperplastic foci, alpha-GT-altered foci and preneoplastic lesions.
Chen
H C
HC
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
D000818:Animals; D004052:Diethylnitrosamine; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D008875:Middle Aged; D011230:Precancerous Conditions / Q000139:chemically induced / Q000235:genetics*; D011493:Protein Kinase C / Q000096:biosynthesis / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018036:Selenium Compounds / Q000494:pharmacology*; D064588:Selenium Oxides; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D018036:Selenium Compounds; D064588:Selenium Oxides; D004052:Diethylnitrosamine; D005723:gamma-Glutamyltransferase; D011493:Protein Kinase C