title: [Synthesis and regulation of growth hormone secretion].
abstract: Human growth hormone (hGH) is a single chain, 22 kd-protein with two intramolecular disulfide bonds. The hGH gene is located on chromosome 17 at band q22-q24 and has four introns separating five coding exons. The expression of hGH is restricted to the pituitary and regulated by GHF-1 which binds to the hGH promoter acting in concert with several other more ubiquitous DNA binding proteins. The secretion of hGH is regulated by GH releasing hormone (GRH) and somatostatin. GRH controls GH synthesis by stimulating transcription of GH mRNA while somatostatin determines the timing and amplitude of GH pulses. Pulsatile GH secretion is influenced by a number of neurogenic, metabolic and hormonal factors.
authors.affiliation: First Dept. of Int. Med. Toho University School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.forename: F
authors.initials: F
authors.lastname: Yakushiji
authors.forename: T
authors.initials: T
authors.lastname: Terazono
mesh_terms: D000595:Amino Acid Sequence; D015870:Gene Expression; D013006:Growth Hormone / Q000096:biosynthesis* / Q000737:chemistry; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010902:Pituitary Gland / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D013004:Somatostatin / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone