title: [Hypersensitivity vasculitis after thrombolytic therapy with APSAC (anisoylated plasminogen streptokinase activator complex). Presentation of a clinical case and review of the literature].
abstract: We describe a rare case of hypersensitivity vasculitis associated with APSAC administration in a 54-year-old man. Fifteen days after receiving thrombolytic therapy (APSAC 30 U) for acute myocardial infarction, the patient was admitted to our department for myalgia, livedo reticularis and erythema of the legs with an ulcerative necrotic lesion of the fifth toe of the right foot. The presence of circulating immune complexes at high titer supported the diagnosis of hypersensitivity vasculitis.
authors.affiliation: I Divisione di Medicina Interna, Nuovo Ospedale S. Giovanni di Dio, U.S.L. 10/C, Firenze.
authors.forename: R
authors.initials: R
authors.lastname: Gianni
authors.forename: M
authors.initials: M
authors.lastname: Benucci
authors.forename: E
authors.initials: E
authors.lastname: Santoro
authors.forename: G
authors.initials: G
authors.lastname: Nenci
authors.forename: M C
authors.initials: MC
authors.lastname: Baruffi
authors.forename: C
authors.initials: C
authors.lastname: Cappelletti
mesh_terms: D016255:Anistreplase / Q000009:adverse effects*; D000936:Antigen-Antibody Complex / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D016255:Anistreplase
vernacular_title: Vasculite da ipersensibilità post-terapia trombolitica con APSAC (anisoylated plasminogen streptokinase activator complex). Presentazione di un caso clinico e revisione della letteratura.