title: A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1).
abstract: The major locus for autosomal dominant polycystic kidney disease (PKD1) is located in a gene-rich region on chromosome 16p13.3. Recently the identification of the gene responsible for PKD1 has been described. While searching for candidate genes in this region, we isolated a new member of the cyclin family. We have characterized the transcript by sequencing, determination of the exon intron boundaries, and Northern blot analysis. Cyclin F is related to A- and B-type cyclins by sequence, but its function is unknown.
authors.affiliation: Imperial Cancer Research Fund, London, United Kingdom.
authors.forename: B
authors.initials: B
authors.lastname: Kraus
authors.forename: M
authors.initials: M
authors.lastname: Pohlschmidt
authors.forename: A L
authors.initials: AL
authors.lastname: Leung
authors.forename: G G
authors.initials: GG
authors.lastname: Germino
authors.forename: A
authors.initials: A
authors.lastname: Snarey
authors.forename: M C
authors.initials: MC
authors.lastname: Schneider
authors.forename: S T
authors.initials: ST
authors.lastname: Reeders
authors.forename: A M
authors.initials: AM
authors.lastname: Frischauf
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D016213:Cyclins / Q000737:chemistry / Q000235:genetics*; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics*; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D050396:TRPP Cation Channels
chemical_list: D016213:Cyclins; D018076:DNA, Complementary; D011506:Proteins; D050396:TRPP Cation Channels; C503669:CCNF protein, human