title: A differential dopamine receptor involvement during stress ulcer formation in rats.
abstract: The involvement of dopaminergic (DA) receptors and their possible interactions were evaluated during stress ulcer formation in rats. The DA1 antagonist SCH 23390 (0.025, 0.05, or 0.1 mg/kg) produced only marginal aggravations in gastric stress pathology when compared to vehicle controls. The DA2 antagonist sulpiride (10 or 50 mg/kg) had dose-related effects. The lower dose aggravated whereas the higher dose attenuated stress ulcerogenesis. The DA2 agonist bromocriptine (2.5 or 5.0 mg/kg), however, attenuated gastric stress ulcers. Pretreatment of rats with the DA depletor alpha-methyl-para-tyrosine or the DA1-antagonist SCH23390 clearly neutralized the stress ulcer-attenuating effects of bromocriptine. These results reaffirm a gastric cytoprotective role for DA and further suggest that DA1-DA2 receptor interactions are crucial during DAergic regulation of gastric mucosal integrity during stress.
authors.affiliation: Department of Pharmacology, University College of Medical Sciences, Shahdara, Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Puri
authors.forename: A
authors.initials: A
authors.lastname: Ray
authors.forename: A K
authors.initials: AK
authors.lastname: Chakravarti
authors.forename: P A
authors.initials: PA
authors.lastname: Sen
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D005753:Gastric Mucosa / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000187:drug effects; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D013276:Stomach Ulcer / Q000473:pathology / Q000503:physiopathology*; D013315:Stress, Psychological / Q000473:pathology*; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D001552:Benzazepines; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D001971:Bromocriptine; D013469:Sulpiride