title: Molecular approaches to the diagnosis and treatment of cancer.
abstract: We have used autologous bone marrow transplantation (ABMT) as a setting to develop the genetic therapy of cancer in hematopoietic neoplasms based on the use of the bone marrow as a conduit through which to introduce regulatory molecules into the patient. This has involved three developmental phases: 1) learning how to develop genetic modification techniques; 2) learning how to develop in vivo selection techniques for the genetically modified cells; and 3) developing molecular vectors for modification of hematopoietic cells for therapy of cancer. These programs will be summarized in terms of their progress at the conference.
authors.affiliation: Department of Hematology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: A B
authors.initials: AB
authors.lastname: Deisseroth
authors.forename: H
authors.initials: H
authors.lastname: Kantarjian
authors.forename: M
authors.initials: M
authors.lastname: Talpaz
authors.forename: R
authors.initials: R
authors.lastname: Champlin
authors.forename: C
authors.initials: C
authors.lastname: Reading
authors.forename: E G
authors.initials: EG
authors.lastname: Hanania
authors.forename: S
authors.initials: S
authors.lastname: Fu
authors.forename: G S
authors.initials: GS
authors.lastname: Randhawa
authors.forename: Y
authors.initials: Y
authors.lastname: Cha
authors.forename: X
authors.initials: X
authors.lastname: Fang
mesh_terms: D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*