Gastroenteropancreatic neuroendocrine tumours contain a common set of synaptic vesicle proteins and amino acid neurotransmitters.
Human neuroendocrine tumours of the gastroenteropancreatic system contain major integral membrane proteins of small synaptic vesicles of neurons, together with characteristic membrane polypeptides of large dense-core vesicles of neurons and neuroendocrine cells. The membrane polypeptides characteristic for small synaptic and large dense-core vesicles are detected in pheochromocytomas (n = 6), functional (n = 6) and non-functional (n = 6) foregut, and midgut carcinoids (n = 17). All gastroenteropancreatic tumours contain large amounts of amino acid neurotransmitters, i.e. glycine and glutamate. gamma-Aminobutyric acid, however, is only found in some foregut carcinoids. Thus, neuroendocrine gastroenteropancreatic tumours possess a vesicle type with a content and membrane composition similar to small synaptic vesicles of neurons.
Ahnert-Hilger
G
G
Department of Internal Medicine, Universitätsklinikum Steglitz, Free University of Berlin, Germany.
Grube
K
K
Kvols
L
L
Lee
I
I
Mönch
E
E
Riecken
E O
EO
Schmitt
L
L
Wiedenmann
B
B
D000818:Animals; D002276:Carcinoid Tumor / Q000737:chemistry*; D005770:Gastrointestinal Neoplasms / Q000737:chemistry; D005971:Glutamates / Q000032:analysis; D005998:Glycine / Q000032:analysis; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis*; D009363:Neoplasm Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis; D018377:Neurotransmitter Agents / Q000032:analysis; D010673:Pheochromocytoma / Q000737:chemistry*; D051381:Rats; D013572:Synaptic Vesicles / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000737:chemistry
D005971:Glutamates; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D005998:Glycine