title: Midline structures and central nervous system coordinates in zebrafish.
abstract: The embryonic zebrafish provides a relatively simple and accessible experimental system for understanding the underlying Bauplan of a vertebrate central nervous system (CNS) and for uncovering interactions critical for patterning. We show that features of CNS organization in normal, mutant, and developmentally ventralized zebrafish embryos can be explained by a three-axis hypothesis: Specifications occur according to position relative to coordinates along the anterior-posterior, dorsal-ventral, and luminal-pial axes of the neural tube. Midline tissues may be responsible for directly establishing the dorsal-ventral coordinates, but may only be indirectly involved in patterning along the anterior-posterior axis.
authors.affiliation: Institute of Neuroscience, University of Oregon, Eugene 97403.
authors.forename: K
authors.initials: K
authors.lastname: Hatta
authors.forename: C B
authors.initials: CB
authors.lastname: Kimmel
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002490:Central Nervous System / Q000002:abnormalities / Q000196:embryology*; D004625:Embryo, Nonmammalian / Q000002:abnormalities / Q000502:physiology / Q000648:ultrastructure; D004627:Embryonic Induction; D005314:Embryonic and Fetal Development; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D005855:Germ Layers / Q000648:ultrastructure; D018398:Homeodomain Proteins; D009024:Morphogenesis; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009672:Notochord / Q000196:embryology; D015398:Signal Transduction; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics; D029961:Zebrafish Proteins; D000099266:Engrailed 2 Protein
chemical_list: D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D029961:Zebrafish Proteins; C079428:en2a protein, zebrafish; D000099266:Engrailed 2 Protein