Tinidazole prophylaxis in elective abdominal hysterectomy.
OBJECTIVE
To determine whether a single dose (2 g) of tinidazole before abdominal hysterectomy could reduce the incidence of postoperative infection.


METHODS
A randomized double-blind placebo-controlled study was undertaken with a single oral dose (2 g) of tinidazole, 12 h before surgery, in 100 patients undergoing abdominal hysterectomy for various benign diseases. Other antibiotic use was withheld until there was no postoperative infection.


RESULTS
A significant reduction (P < 0.05) of infectious morbidity (28% vs. 8%) as well as a decrease in additional antibiotic use (P < 0.01) and duration of hospital stay (P < 0.001) was observed. Febrile morbidity was also reduced from 36% to 14% (P < 0.05). Tinidazole was tolerated well by all the patients.


CONCLUSIONS
Tinidazole prophylaxis (2 g oral dose) is considered to be a simple, safe and effective way to reduce postoperative infection in abdominal hysterectomy.
Dhar
K K
KK
Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research Chandigarh India.
Dhall
G I
GI
Ayyagari
A
A
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015994:Incidence; D008875:Middle Aged; D009017:Morbidity; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D014011:Tinidazole / Q000008:administration & dosage* / Q000627:therapeutic use
D014011:Tinidazole