S-mephenytoin, sparteine and debrisoquine oxidation: genetic polymorphisms in a Turkish population.
A mephenytoin test was carried out in 106 unrelated healthy Turkish volunteers. Racemic mephenytoin was coadministered with either debrisoquine or sparteine. The S/R mephenytoin ratio ranged from < 0.1 to 0.73 in 105 subjects, accordingly phenotyped as extensive metabolisers. One subject had an S/R mephenytoin ratio of 1.02, showing that he was a poor metaboliser of mephenytoin (0.94%, confidence interval 0.25% and 13.65%). In 48 subjects, the metabolic ratios of debrisoquine and sparteine were correlated significantly (rs = 0.61, P < 0.001).
Basci
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NE
Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Brosen
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K
Bozkurt
A
A
Isimer
A
A
Sayal
A
A
Kayaalp
S O
SO
D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003647:Debrisoquin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006282:Health Personnel; D006801:Humans; D008297:Male; D008617:Mephenytoin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D008875:Middle Aged; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic / Q000235:genetics; D013034:Sparteine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D013237:Stereoisomerism; D014421:Turkey; D044465:White People / Q000235:genetics*
D013034:Sparteine; D008617:Mephenytoin; D003647:Debrisoquin