[The neuropeptide PACAP: its presence, its mode of action and its receptors].
Specific PACAP type I receptors show 200- 1000-fold higher affinity for both PACAPS as compared to VIP. Their occupancy stimulates adenylate cyclase and frequently also the inositol phosphate-calcium cascade. Considering a few PACAP-38 and PACAP-27 effects exerted on the hypothalamo-hypophyseal axis and elsewhere, there appears already that these neuropeptides may play a physiological role even more important than that of VIP.
Christophe
J
J
Laboratoire de Chimie biologique et de la nutrition, faculté de Médecine de l'Université libre de Bruxelles.
D000818:Animals; D002395:Catecholamines / Q000096:biosynthesis; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008550:Melatonin / Q000096:biosynthesis; D009479:Neuropeptides / Q000494:pharmacology / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone / Q000502:physiology*; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
C495401:ADCYAP1 protein, human; C495403:Adcyap1 protein, rat; D002395:Catecholamines; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone; D014660:Vasoactive Intestinal Peptide; D008550:Melatonin
Le neuropeptide PACAP: sa présence, son mode d'action et ses récepteurs.