Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery.
Bioadhesive tablets for intraoral drug delivery were prepared by directly compressing the drug with a mixture of chitosan and sodium alginate in weight ratios of 4:1, 1:1 and 1:4, and the adhesion and release characteristics of the prepared systems were evaluated in vitro and in vivo. Ketoprofen was used as a model drug. The magnitudes of the adhesion force of chitosan/alginate tablets were observed to be comparable to that of Aftach, which is a typical commercial preparation of an oral mucosal adhesive tablet. Increasing the chitosan content in the tablets resulted in a decrease in the release rate of ketoprofen. When the tablets were administered to the sublingual site of rabbits, ketoprofen from the tablets with chitosan/alginate was rapidly absorbed without an initial sharp peak. Furthermore, the plasma concentration curves for the tablet with a 1:4 chitosan/alginate ratio showed a sustained release 3 h after administration. The data presented suggest that tablets prepared from chitosan and alginate are potential candidates for intraoral drug delivery.
Miyazaki
S
S
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Japan.
Nakayama
A
A
Oda
M
M
Takada
M
M
Attwood
D
D
D000268:Adhesiveness; D000286:Administration, Sublingual; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan; D016503:Drug Delivery Systems; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D007408:Intestinal Absorption; D007660:Ketoprofen / Q000008:administration & dosage / Q000493:pharmacokinetics; D010529:Peritoneal Cavity; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D051381:Rats; D012995:Solubility; D013607:Tablets
D000464:Alginates; D006603:Hexuronic Acids; D014677:Pharmaceutical Vehicles; D013607:Tablets; D002686:Chitin; D020723:Glucuronic Acid; D048271:Chitosan; D007660:Ketoprofen