Dynorphin A-(1-13) attenuates basal forebrain-lesion-induced amnesia in rats.
The effects of dynorphin A-(1-13), an endogenous kappa opioid agonist, on basal forebrain (BF)-lesion-induced amnesia in rats were investigated using step-through-type passive avoidance task. The BF was lesioned by injecting the cholinergic neurotoxin ibotenic acid (6 micrograms/side). The number of rats achieving the cut-off time (600 s) of step-through latency (STL) in BF-lesioned group significantly decreased as compared with that in sham-operated group. Dynorphin A-(1-13) (0.3 micrograms) significantly increased the number of rats achieving the cut-off time of STL in BF-lesioned rats. These results suggest that dynorphins play an improving role in the impairment of memory processes in BF-lesioned rats.
Ukai
M
M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Kobayashi
T
T
Kameyama
T
T
D000544:Alzheimer Disease / Q000188:drug therapy*; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D004195:Disease Models, Animal; D004399:Dynorphins / Q000494:pharmacology*; D007051:Ibotenic Acid; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D016548:Prosencephalon / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D017473:Receptors, Opioid, kappa / Q000187:drug effects*
D010446:Peptide Fragments; D017473:Receptors, Opioid, kappa; D007051:Ibotenic Acid; C026843:dynorphin (1-13); D004399:Dynorphins