An atypical myeloproliferative disorder with t(8;13) (p11;q12): a third case.
A 43-year-old male presented with a myeloproliferative disorder with prominent lymphadenopathy. Examination of the bone marrow showed almost complete replacement by a population of cells with an acquired chromosomal translocation t(8;13)(p11;q12). There are two other case reports describing a similar clinical syndrome with t(8;13)(p11;q12) as the sole chromosomal aberration in bone marrow cells, suggesting a role for this translocation in the pathogenesis of this myeloproliferative disorder.
Macdonald
D
D
LRF Centre for Adult Leukaemia, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Sheerin
S M
SM
Cross
N C
NC
Spencer
A
A
Goldman
J M
JM
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D002908:Chronic Disease; D006801:Humans; D008297:Male; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic