[Antimitotic compounds as modifiers of the radiation lesion of cultured cells].
The features of antimitotic substances as radioprotectors were studied. In vitro experiments have demonstrated that taxol revealed radioprotective features concerning the process of polymerization of irradiated microtubules. These results were the basis for the use of taxol and some other substances with high affinity for cytoskeleton proteins as potential radiomodificators in vivo. Experiments with cultivated fibroblasts revealed that colchicine significantly enhances radioactive injuries of cells while taxol and phalloidin manifest their radioprotective features.
Sorochinskiĭ
B V
BV
Prokhnevskiĭ
A I
AI
Grodzinskiĭ
D M
DM
Shmigovskaia
V V
VV
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D001921:Brain / Q000648:ultrastructure; D002417:Cattle; D003078:Colchicine / Q000627:therapeutic use / Q000633:toxicity; D003598:Cytoskeletal Proteins / Q000187:drug effects / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D007739:L Cells / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008870:Microtubules / Q000187:drug effects / Q000528:radiation effects; D017239:Paclitaxel / Q000627:therapeutic use / Q000633:toxicity; D010590:Phalloidine / Q000627:therapeutic use / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000473:pathology; D011837:Radiation-Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D013997:Time Factors
D000970:Antineoplastic Agents; D003598:Cytoskeletal Proteins; D011837:Radiation-Protective Agents; D010590:Phalloidine; D017239:Paclitaxel; D003078:Colchicine
Antimitoticheskie soedineniia kak modifikatory luchevogo porazheniia kul'tiviruemykh kletok.