title: Circulating abnormal cells detected in a patient with immunoblastic lymphadenopathy.
abstract: An unusual case of immunoblastic lymphadenopathy (IBL) with circulating CD3-CD4+ cells is reported. A lymph node biopsy specimen showed the characteristic features of IBL. Two-color analyses demonstrated that the circulating abnormal cells were CD3-, CD4+, HLA-DR+, and CD25-. Chromosomal analysis revealed unrelated clones in the lymph node. Though 48% of the peripheral blood lymphocytes were abnormal, no clonal rearrangement of the TcR beta chain gene was detected in the peripheral blood. This case might point out the possibility that some cases of IBL truly had no TcR gene rearrangement and were dysplasias.
authors.affiliation: Department of Hematology, Showa University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishiyama
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Akimoto
authors.forename: H
authors.initials: H
authors.lastname: Ueno
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Koike
authors.forename: K
authors.initials: K
authors.lastname: Hino
authors.forename: S
authors.initials: S
authors.lastname: Tomoyasu
authors.forename: N
authors.initials: N
authors.lastname: Tsuruoka
authors.forename: H
authors.initials: H
authors.lastname: Ota
mesh_terms: D017252:CD3 Complex / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology*; D002999:Clone Cells / Q000473:pathology; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000032:analysis
chemical_list: D017252:CD3 Complex; D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2; D011239:Prednisolone