title: Quantitative anti-p24 determinations can predict the risk of vertical transmission. Swiss HIV and Pregnancy Collaborative Study Group.
abstract: Quantitative serum antibody to p24 was evaluated as a predictor of risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) infection. HIV-positive mothers, 13 with HIV-infected children and 24 with noninfected children were investigated during pregnancy and at the time of delivery. A statistically significant difference in anti-p24 titers was found between the mothers with infected and those with noninfected children independent of whether antibodies were measured during pregnancy or at the time of delivery. High anti-p24 levels correlated with a low risk of vertical transmission, whereas low anti-p24 titers were associated with an increased risk of vertical transmission. Although the number of CD4+ T-cells was lower and neopterin and beta-2 microglobulin values were higher in the group of mothers with infected children than in the noninfected group, no statistical significance was achieved due to the small sample size.
authors.affiliation: Institute for Medical Microbiology, University of Basel, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Erb
authors.forename: S
authors.initials: S
authors.lastname: Kräuchi
authors.forename: D
authors.initials: D
authors.lastname: Bürgin
authors.forename: K
authors.initials: K
authors.lastname: Biedermann
authors.forename: C
authors.initials: C
authors.lastname: Camli
authors.forename: C
authors.initials: C
authors.lastname: Rudin
mesh_terms: D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D015496:CD4-Positive T-Lymphocytes; D005260:Female; D015700:HIV Envelope Protein gp41 / Q000097:blood*; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D019798:Neopterin; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011379:Prognosis; D012307:Risk Factors; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D015700:HIV Envelope Protein gp41; D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin