Effects of 2,5-dimethylpyrazine on plasma testosterone and polyamines- and acid phosphatase-levels in the rat prostate.
The effects of 2,5-dimethylpyrazine (DMP) on plasma testosterone and levels of polyamines and acid phosphatase in the prostate of rat were studied. A high dose of DMP administered once daily for two weeks to juvenile male rats significantly decreased plasma testosterone and levels of polyamines and acid phosphatase in the prostate. These effects were not obtained by administration to mature male rats, and the inhibition was thus recognized to occur during the growth period. These findings suggest that a high dose of DMP inhibits the biosynthesis of polyamines and acid phosphatase in the prostate by decreasing the circulating testosterone level.
Yamada
K
K
Tokyo College of Pharmacy, Japan.
Shimizu
A
A
Komatsu
H
H
Sakata
R
R
Ohta
A
A
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D015317:Biogenic Polyamines / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D008297:Male; D011467:Prostate / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet; D013739:Testosterone / Q000097:blood*
D015317:Biogenic Polyamines; D011719:Pyrazines; D013739:Testosterone; D000135:Acid Phosphatase; C075524:2,5-dimethylpyrazine