[Synthesis, biological activity and encapsulation of new adrenergic beta-amino alcohols in phospholipid liposomes].
New beta-amino-alcohols were synthesized and showed beta-blocking biological activity. These potential drugs, as well as natrium salicylate, have been entrapped in phospholipid liposomes. Drug-containing liposomes were prepared from egg lecithin and DPPC (Dipalmitoylphosphatidylcholine) by the injection method. Turbidity measurements and dynamic light scattering were used to characterise the liposome and to study their stability during storage. The entrapment efficiency of the drugs in liposomes was correlated to the partition coefficient of the drugs.
Imzil
L
L
Université Hassan II Ain Chock, Faculté des Sciences, Casablanca, Maroc.
Elamrani
K
K
Charaf
A
A
Bouzoubaa
M
M
Leclerc
G
G
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D000605:Amino Alcohols / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D004337:Drug Carriers; D004339:Drug Compounding; D008081:Liposomes; D010743:Phospholipids; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids
Synthèse, activité biologique et encapsulation de nouveaux beta-amino-alcools adrénergiques dans des liposomes phospholipidiques.