title: The role of dermorphin in the regulation of the processes of hibernation in mammals.
abstract: Data are presented in this paper regarding the influence of the opioid peptide, dermorphin, and its conjugate on the conditioned reflex activity of sousliks. The administration of dermorphin (0.1 mu/g, subcutaneously) is accompanied by a fall in body temperature, slowing of the baseline vegetative indices, and the sinking of the animal into a sleep-like state. A substantial disturbance of conditioned reflex activity was identified in the late period (delayed effects). Immunization of the hibernating sousliks with a conjugate of dermorphin leads to a gradual awakening of the animals from hibernation, to the normalization of conditioned reflex activity, and to the appearance of the motoric component of a conditioned defense reaction. The question of a possible specific role of dermorphin in the mechanisms of hibernation is discussed.
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg.
authors.forename: T N
authors.initials: TN
authors.lastname: Sollertinskaya
authors.forename: E N
authors.initials: EN
authors.lastname: Nuritdinov
authors.forename: M F
authors.initials: MF
authors.lastname: Obukhova
mesh_terms: D000698:Analgesia; D000701:Analgesics, Opioid / Q000276:immunology / Q000494:pharmacology*; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D006605:Hibernation / Q000187:drug effects*; D009842:Oligopeptides / Q000276:immunology / Q000494:pharmacology*; D018847:Opioid Peptides; D012377:Rodentia / Q000502:physiology*; D012879:Skin Physiological Phenomena; D012881:Skin Temperature / Q000187:drug effects
chemical_list: D000701:Analgesics, Opioid; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin