title: Familial occurrence of narcolepsy in miniature horses.
abstract: In an investigation of 2 closely related Miniature Horses with a history of excessive sleepiness, depression and episodes of collapse, a diagnosis of narcolepsy was made on the basis of neurological examination and pharmacological testing. Further investigations included electroencephalographic examination (EEG), and analysis of protein content, cell count and monoamine metabolite concentrations of lumbosacral cerebrospinal fluid (CSF). There were no abnormalities noted in the EEGs, and no consistent changes in CSF neurotransmitter metabolites in the narcoleptic horses when compared with 3 normal, unrelated Miniature Horses and 2 related, clinically unaffected animals. The breeding background of the 2 affected horses was investigated and a limited survey of Miniature Horse breeders in North America was conducted. These investigations have shown that narcolepsy is a rare but distinct syndrome in the Miniature Horse, and that the cases described here appear to represent a familial occurrence of the disease.
authors.affiliation: School of Veterinary Medicine, University of Wisconsin, Madison 53706.
authors.forename: D P
authors.initials: DP
authors.lastname: Lunn
authors.forename: P A
authors.initials: PA
authors.lastname: Cuddon
authors.forename: S
authors.initials: S
authors.lastname: Shaftoe
authors.forename: R M
authors.initials: RM
authors.lastname: Archer
mesh_terms: D000818:Animals; D001285:Atropine; D001947:Breeding; D004569:Electroencephalography / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis / Q000235:genetics*; D006736:Horses; D007099:Imipramine; D008297:Male; D009290:Narcolepsy / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D009388:Neostigmine; D009460:Neurologic Examination / Q000662:veterinary; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid; D010375:Pedigree; D010830:Physostigmine / Q000031:analogs & derivatives
chemical_list: D018377:Neurotransmitter Agents; C026718:physostigmine salicylate; D009388:Neostigmine; D001285:Atropine; D010830:Physostigmine; D007099:Imipramine