[HLA haplotypes and the predisposition to diffuse toxic goiter].
The results of the family immunogenetic study compared to HLA-typing on the population-genetic level have established a population positive association which was more strong with HLA system regions B and DR (antigens B17, B35, DR5). Haplotype HLA A3, B35, DR5 may be considered as the haplotype of predisposition to diffuse toxic goiter. The strength of the association DT3 with antigens A3, B35, DR5 in the family study was superior to that in the population one. A new association of antigen HLA B44 with family variant of the goiter was revealed as was the fact that the proband's parents carry the predisposition haplotype, the segregation being from the parents to sibs and the proband's children. Registration in the children of the proband of the predisposition haplotype or separate antigens (B17, B35, B44, DR5) suggests the risk of diffuse toxic goiter in the proband's children.
Kamynina
T S
TS
Manishkina
V P
VP
Stepanova
E B
EB
D000293:Adolescent; D000328:Adult; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011379:Prognosis; D012307:Risk Factors
D006680:HLA Antigens
HLA-gaplotipy i predraspolozhennost' k diffuznomu toksicheskomu zobu.