Borna disease virus-specific T cells protect against or cause immunopathological Borna disease.
In this report we show that passive immunization of Lewis rats with viable CD4+, Borna disease virus (BDV)-specific T cells before infection with BDV resulted in protection against BD, whereas inoculation of these T cells after BDV infection induced clinical disease with more rapid onset than seen in BDV control animals. The protective as well as encephalitogenic effector functions of BDV-specific CD4+ T cells were mediated only by viable BDV-specific T cells. The protective situation was obtained by passive transfer of BDV-specific T cells into animals inoculated later with virus, whereas the immunopathological situation was observed when virus-specific T cells developed normally or after adoptive transfer, and appeared on the scene after considerable virus replication in the brain.
Richt
J A
JA
Institut für Virologie, Giessen, Germany.
Schmeel
A
A
Frese
K
K
Carbone
K M
KM
Narayan
O
O
Rott
R
R
D000818:Animals; D001890:Borna Disease / Q000276:immunology* / Q000517:prevention & control; D001891:Borna disease virus / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D016219:Immunotherapy, Adoptive; D051381:Rats; D011917:Rats, Inbred Lew