Erythema multiforme and hypersensitivity myocarditis caused by ampicillin.
OBJECTIVE
To report a case of erythema multiforme and hypersensitivity myocarditis caused by ampicillin.


METHODS
A 13-year-old boy was treated with ampicillin and gentamicin because of suspected septicemia. Medications were discontinued when erythema multiforme and congestive heart failure caused by myocarditis occurred. The patient was treated with methylprednisolone and gradually improved. Macrophage-migration inhibition (MIF) test with ampicillin was positive.


CONCLUSIONS
After most infections causing erythema multiforme and myocarditis were ruled out, a drug-induced allergic reaction was suspected. Positive MIF test for ampicillin showed sensitization of the patient's lymphocytes to ampicillin.


CONCLUSIONS
Hypersensitivity myocarditis is a rare and dangerous manifestation of allergy to penicillins.
Garty
B Z
BZ
Kipper Institute of Allergy and Immunology Children's Medical Center of Israel, Beilinson Medical Campus, Petah Tiqva.
Offer
I
I
Livni
E
E
Danon
Y L
YL
D000293:Adolescent; D000667:Ampicillin / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004892:Erythema Multiforme / Q000139:chemically induced*; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000139:chemically induced*
D000667:Ampicillin