Asymmetric expression of a novel homeobox gene in vertebrate sensory organs.
A novel homeobox gene, SOHo-1, was isolated from embryonic chicken retina. On embryonic day 2 (E2), SOHo-1 is expressed in the retina, posterolateral otic pit, and neural tube anterior to the spinal cord. On E4, SOHo-1 is expressed at high levels in anterior retina and low levels in posterior retina, suggestive of a role in patterning the anterior-posterior axis. It is also expressed on E4 in the otocyst, the dorsal root ganglia, some cranial ganglia, and the second branchial arch. SOHo-1 expression in the otic pit and otocyst is restricted to regions that will give rise to the nonsensory tissues of the inner ear. SOHo-1 is not closely related to any identified vertebrate or Drosophila homeobox-containing genes. Since it is expressed in sensory-related structures and does not fit into existing classes of homeobox genes, we propose the name SOHo-1, for sensory organ homeobox-1.
Deitcher
D L
DL
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Fekete
D M
DM
Cepko
C L
CL
D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D001483:Base Sequence; D015152:Blotting, Northern; D002642:Chick Embryo; D017931:DNA Primers; D004330:Drosophila / Q000235:genetics; D004423:Ear / Q000196:embryology; D005314:Embryonic and Fetal Development; D005724:Ganglia / Q000196:embryology / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000196:embryology / Q000378:metabolism; D015870:Gene Expression; D015723:Gene Library; D005801:Genes, Homeobox; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D016366:Open Reading Frames; D009928:Organ Specificity; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D012160:Retina / Q000196:embryology / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
D030161:Avian Proteins; D017931:DNA Primers; D009419:Nerve Tissue Proteins; C085723:SOHO-1 protein, Gallus gallus