Increased mortality due to cardiovascular disease in type 1 diabetic patients transplanted for end-stage renal failure.
The graft and patient survivals following renal transplantation in all Type 1 diabetic patients transplanted within the North-West of England between 1981 and 1990 at Manchester Royal Infirmary were studied. Fifty-two Type 1 (insulin-dependent) diabetic patients with end-stage renal failure due to diabetic nephropathy were transplanted during this period. They were compared to controls matched for age, sex, and year of transplantation and also to all 904 patients transplanted during the same period. Graft survival rates at 1 and 5 years in the diabetic patients were lower (80.8% and 62.1%, respectively), compared to controls (88.9% and 77.9%, respectively, p = 0.02) but were similar to those seen in all grafts (80.4% and 59.0%, respectively, p = NS). Actuarial patient survival rate at 5 years was lower in diabetic patients (76.3%) compared to the control group (94.2%, p = 0.003). Myocardial infarction was the main cause (60%) of death in diabetic patients. The results of this large recent series indicate that good graft and patient survival rates can be obtained in Type 1 diabetic patients, although they remain poorer than those of patients with non-diabetic renal disease. More rigorous pretransplantation cardiac assessment and treatment before acceptance of Type 1 diabetic patients for renal transplantation may help to improve patient survival.
Kumar
S
S
Manchester Royal Infirmary, UK.
Merchant
M R
MR
Dyer
P
P
Martin
S
S
Hutchison
A J
AJ
Johnson
R W
RW
Boulton
A J
AJ
Gokal
R
R
D000328:Adult; D002318:Cardiovascular Diseases / Q000401:mortality*; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000401:mortality*; D004739:England / Q000453:epidemiology; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000401:mortality*; D016030:Kidney Transplantation / Q000276:immunology* / Q000401:mortality*; D008297:Male; D015996:Survival Rate