title: [The effect of environmental factors on the concentration of tumor markers in the blood serum and on the indices characterizing thyroid function].
abstract: Combined versus separate exposure of male organism to cesium-137 and chemical agents results in a more pronounced hyperferritinemia in the former case. In female chemists the ferritin level is dependent to a considerable extent on the menstrual cycle showing a tendency for the iron-containing protein level to decrease because of the action of a number of chemical agents. The rise of the level of cancer embryonic antigen is more readily seen in persons with high levels of cesium-137. Concentrations of carbohydrate antigen (CA-125) and mucin-like antigen are appreciably higher in female chemists incorporating cesium-137, and in those within the 30-km radius of the ChNPP. The level of thyroglobulin was raised in the chemists having a background incorporation of cesium, the liquidators of the aftermaths, and particularly in those happened to be in the 30-km zone. Each of the unfavourable factors taken separately (chemical agent or cesium-137) had lesser effect on the degree of elevation of TG content and hormone-forming function of the thyroid gland. An additional information has been obtained concerning the risk groups, which, however, serves as an indirect measure of carcinogenic effect various environmental factors exert on the organism.
authors.forename: V V
authors.initials: VV
authors.lastname: Shishkina
authors.forename: E D
authors.initials: ED
authors.lastname: Chebotareva
authors.forename: S S
authors.initials: SS
authors.lastname: Zamiatin
authors.forename: B F
authors.initials: BF
authors.lastname: Siniuta
authors.forename: L N
authors.initials: LN
authors.lastname: Nikolenko
authors.forename: O O
authors.initials: OO
authors.lastname: Vlasenko
authors.forename: L G
authors.initials: LG
authors.lastname: Iugrinova
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood* / Q000528:radiation effects; D002617:Chemical Industry; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D011210:Power Plants; D018788:Radioactive Hazard Release; D013954:Thyroglobulin / Q000097:blood / Q000187:drug effects / Q000528:radiation effects; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D013963:Thyroid Hormones / Q000097:blood / Q000528:radiation effects; D014455:Ukraine; D014505:Urban Population
chemical_list: D014408:Biomarkers, Tumor; D013963:Thyroid Hormones; D013954:Thyroglobulin
vernacular_title: Vliianie nekotorykh faktorov okruzhaiushchweĭ sredy na kontsentratsiiu v syvorotke krovi opukholevykh markerov i pokazateli, kharakterizuiushchie sostoianie shchitovidnoĭ zhelezy.