Effect of Viscum album L. on rapidly proliferating amniotic fluid cells. Sister chromatid exchange frequency and proliferation index.
Amniotic fluid cells (AFC) from 10 women undergoing amniocentesis were investigated. The 5-bromo-2'-deoxyuridine-induced sister chromatid exchange (SCE) frequency of AFC remained stable after the addition of a therapeutical concentration of Viscum album L. preparation Iscador P but decreased significantly after administration of high drug doses. As the proliferation index remained stable, even at extremely high drug concentrations, this effect could not be ascribed to a reduction of proliferation. No indications of cytogenetic damage or effects of mutagenicity were seen after the addition of Viscum album L. preparation P.
Büssing
A
A
Institute of Medical Immunology, Faculty of Medicine, Technical University, Aachen, Fed. Rep. of Germany.
Lehnert
A
A
Schink
M
M
Mertens
R
R
Schweizer
K
K
D000653:Amniotic Fluid / Q000166:cytology* / Q000187:drug effects; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000187:drug effects; D005260:Female; D006801:Humans; D014784:Mistletoe / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D010936:Plant Extracts; D004247:DNA; D001973:Bromodeoxyuridine