title: Comparison of velocity and volumetric indexes of left ventricular filling during increased heart rate with exercise and amyl nitrite.
abstract: Physiologic variables, such as heart rate, affect the noninvasive indexes of left ventricular filling, complicating the interpretation of these indexes for clinical assessment of diastolic function. We compared the effect in normal subjects of increased heart rate provoked by both exercise and amyl nitrite on noninvasive velocity and volumetric indexes of left ventricular filling. Velocity indexes were affected in a different pattern with exercise compared with amyl nitrite because peak E wave velocity and relative atrial contribution to filling increased with exercise. In contrast, the volumetric index of rapid left ventricular filling increased similarly with both mechanisms. These findings demonstrate the importance of recognizing the different effects on indexes of left ventricular filling when heart rate is increased by different methods.
authors.affiliation: Division of Cardiology, University of Florida College of Medicine, University of Florida Health Science Center-Jacksonville 32209.
authors.forename: R F
authors.initials: RF
authors.lastname: Percy
authors.forename: D A
authors.initials: DA
authors.lastname: Conetta
mesh_terms: D000328:Adult; D000680:Amyl Nitrite / Q000494:pharmacology*; D016279:Atrial Function, Left / Q000187:drug effects / Q000502:physiology; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology*; D002306:Cardiac Volume / Q000187:drug effects / Q000502:physiology*; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology*
chemical_list: D000680:Amyl Nitrite