title: X-linked immunodeficiencies.
abstract: In the past year, researchers have identified the genes responsible for X-linked severe combined immunodeficiency (encoding a cytokine receptor protein), X-linked agammaglobulinemia (encoding a cytoplasmic tyrosine kinase) and X-linked hyper IgM syndrome (encoding the ligand for CD40). Although these three genes are completely unrelated, it is of interest that all are lineage-specific genes that are involved in the control of lymphocyte proliferation or differentiation.
authors.affiliation: Department of Pediatrics, University of Tennessee College of Medicine, St Jude Children's Research Hospital, Memphis 38105.
authors.forename: M E
authors.initials: ME
authors.lastname: Conley
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics; D002648:Child; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D006942:Hypergammaglobulinemia / Q000235:genetics; D007075:Immunoglobulin M; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D007231:Infant, Newborn; D008297:Male; D016511:Severe Combined Immunodeficiency / Q000235:genetics; D014960:X Chromosome
chemical_list: D007075:Immunoglobulin M