title: Succinylcholine and vecuronium blockade of the diaphragm, laryngeal and limb muscles in the anaesthetized goat.
abstract: The purpose of the study was to compare the response of the cricoarytenoideus dorsalis muscle (CD) to neuromuscular blocking drugs with those of the thyroarytenoideus (TA), diaphragm (DI) and ulnaris lateralis (UL) muscles. Evoked electromyographic response to indirect supramaximal stimulation at 1 Hz was monitored in ten adult goats under thiopentone-halothane anaesthesia. The onset time and duration of neuromuscular blockade after intravenous administration of 500 micrograms.kg-1 of succinylcholine or 4 micrograms.kg-1 of vecuronium were determined. Times to 100% paralysis in CD, TA, DI and UL after succinylcholine were (mean +/- SD) 39 +/- 11, 39 +/- 11, 42 +/- 8 and 57 +/- 8 seconds, respectively; the corresponding times for vecuronium were 5.6 +/- 2.3, 4.6 +/- 1.7, 6.0 +/- 1.9 and 9.6 +/- 1.7 min. The order of recovery to 25% spontaneous EMG activity was TA, CD, DI and UL after succinylcholine (durations: 9.7 +/- 3.6, 11.0 +/- 3.0, 15.3 +/- 1.3 and 22.0 +/- 1.2 min, respectively) but DI, CD, TA and UL after vecuronium (durations: 31.9 +/- 18.6, 35.2 +/- 19.5, 47.1 +/- 19.9 and 71.7 +/- 16.1 minutes, respectively). Thus, as in the diaphragm and thyroarytenoideus muscles, onset time and duration of succinylcholine or vecuronium blockade were shorter in the abductor muscle of the glottis, cricoarytenoideus dorsalis, than in the limb muscle.
authors.affiliation: Department of Clinical Veterinary Medicine, University of Cambridge, England.
authors.forename: C
authors.initials: C
authors.lastname: Ibebunjo
authors.forename: L W
authors.initials: LW
authors.lastname: Hall
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D000818:Animals; D003964:Diaphragm / Q000187:drug effects*; D004576:Electromyography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005552:Forelimb; D006041:Goats; D006221:Halothane; D007821:Laryngeal Muscles / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D012121:Respiration, Artificial; D013390:Succinylcholine / Q000494:pharmacology*; D013874:Thiopental; D013997:Time Factors; D014673:Vecuronium Bromide / Q000494:pharmacology*
chemical_list: D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D013390:Succinylcholine; D013874:Thiopental; D006221:Halothane