Assignment of the human type I IMP dehydrogenase gene (IMPDH1) to chromosome 7q31.3-q32).
Two phage lambda clones that contain the 5' portion of the human type I inosine 5'-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205) gene were isolated. Both polymerase chain reaction analysis of a panel of human-mouse and human-hamster cell somatic hybrids using primers specific for the type I IMPDH gene and fluorescence in situ hybridization with metaphase human chromosomes using type I IMPDH genomic DNA as probes indicate that the type I IMPDH gene (symbol IMPDH1) is located on chromosome 7. Sequential GTG-banding was performed to assign the band location of the type I IMPDH gene to chromosome 7q31.3-q32.
Gu
J J
JJ
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27599.
Kaiser-Rogers
K
K
Rao
K
K
Mitchell
B S
BS
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D006224:Cricetinae; D017931:DNA Primers; D006801:Humans; D006822:Hybrid Cells; D007168:IMP Dehydrogenase / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008969:Molecular Sequence Data
D017931:DNA Primers; D007168:IMP Dehydrogenase