Noradrenergic modulation of avian kidney function.
Norepinephrine (NE) infused at doses of 0.7, 2.2 and 6.7 micrograms/min/kg body weight into conscious, salt and water loaded ducks dose-dependently induced arterial hypertension, reflex bradycardia and diuresis/natriuresis at unchanged glomerular filtration and reduced renal blood flow. NE-induced changes in plasma concentrations of osmoregulatory hormones consisted of a slight increase for the antidiuretic hormone, no change for angiotensin II and a nearly 4-fold increase for atrial natriuretic factor. Sub-pressor doses of NE infused close to the origin of the renal arteries induced diuresis without a rise in urinary sodium concentration. The results suggest pressure diuresis in ducks as a response to hypertensive NE doses with a possible contribution of atrial natriuretic factor to natriuresis.
Jungbluth
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D
Max-Planck-Institut für Physiologische und Klinische Forschung, W.G. Kerckhoff-Institut, Bad Nauheim, F.R.G.
Simon-Oppermann
C
C
Schütz
H
H
Gerstberger
R
R
Simon
E
E
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004372:Ducks / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology* / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects; D014668:Vasotocin / Q000097:blood
D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D014668:Vasotocin; D009638:Norepinephrine