Cyclopropamitosenes: novel bioreductive anticancer agents--mechanism of action and enzymic reduction.
The mechanism of action of cyclopropamitosenes, novel bioreductive anticancer agents, has been investigated using a unique combination of chemical and biochemical techniques. The compounds 4 function as reductively activated alkylating agents under chemical reducing conditions, and the biochemical experiments establish that the methoxy- and aziridinyl-derivatives 4a and 4b behave differently upon bioreduction.
Moody
C J
CJ
Department of Chemistry, Loughborough University of Technology, UK.
O'Sullivan
N
N
Stratford
I J
IJ
Stephens
M A
MA
Workman
P
P
Bailey
S M
SM
Lewis
A
A
D000477:Alkylating Agents / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology*; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D008937:Mitomycins / Q000378:metabolism* / Q000494:pharmacology*; D010084:Oxidation-Reduction
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D008937:Mitomycins