[The pharmacodynamic and hypotensive efficacy of proxodolol in an acute drug test on hypertension patients].
The antihypertensive efficacy and hemodynamic effects of the new hybrid (beta-, alpha-) adrenoceptor blocking agent proxodolol were studied in 74 patients with mild, moderate, and severe arterial hypertension who received a single dose of 10, 20, or 40 mg. Oral and intravenous proxodolol showed a significant dose-dependent antihypertensive action which was independent of the type of hemodynamics and manifested itself by decreasing cardiac output.
Kukes
V G
VG
Starodubtsev
A K
AK
Smirnov
M V
MV
Petrov
I N
IN
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010069:Oxadiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D013607:Tablets; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D010069:Oxadiazoles; D013607:Tablets; C088649:proxodolol
Farmakodinamika i gipotenzivnaia éffektivnost' proksodolola v usloviiakh ostrogo lekarstvennogo testa u bol'nykh gipertonicheskoĭ bolezn'iu.