title: A simple simulation for the visualisation of CSF flow in infants with hydrocephalus.
abstract: Cerebrospinal fluid (CSF) flow was demonstrated incidentally in our unit during the routine cranial colour Doppler examination of infants with hydrocephalus. Pulsed Doppler analysis of the flow jets within CSF has shown that for each CSF flow jet there is a characteristic sinusoidal wave pattern that decreases in amplitude at the end of each jet episode. Any activity that transiently elevates the intracranial pressure, such as crying, increased the intensity of this signal. A study was subsequently carried out to investigate the origin of these clinical observations of CSF flow. Using a simple flow phantom, experiments with degassed water demonstrated the transient production of a Doppler signal at a stenosis in an otherwise uniform bore tube. We postulate that in infants with obstructive hydrocephalus, high CSF velocities in excess of 25 cm/s are produced as a result of the pressure caused by the excess cerebrospinal fluid. In some instances fluid jets may give rise to the production of microbubbles that act as transient but extremely efficient reflectors for the ultrasound, thus enabling the visualisation of CSF flow in these patients.
authors.affiliation: Department of Medical Physics, University Hospital, Nottingham, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Perkins
authors.forename: S C
authors.initials: SC
authors.lastname: Lawes
authors.forename: L A
authors.initials: LA
authors.lastname: Mitchell
authors.forename: T
authors.initials: T
authors.lastname: Jaspan
mesh_terms: D002555:Cerebrospinal Fluid / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007231:Infant, Newborn; D008961:Models, Structural; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*