Studies on a new radiopaque polymeric biomaterial.
A new radiopaque polymeric biomaterial has been synthesized. The material, which actually represents an entire family of analogous radiopaque materials, is composed of 2-(p-iodobenzoyl)-ethyl methacrylate (compound 1, 21 mol%), methyl methacrylate (MMA, 60 mol%), and 2-hydroxyethyl methacrylate (HEMA, 19 mol%). The terpolymer was synthesized in a radical polymerization reaction at elevated temperature in N,N-dimethylformamide (DMF). The product was subjected to a set of physicochemical characterization techniques (gel permeation chromatography, 500 MHz 1H NMR in deuterated dimethylsulphoxide (d6-DMSO) solution, differential scanning calorimetry, dynamic water contact angle measurements), as well as to an in vitro thrombogenicity assay. Furthermore, scanning electron microscopy was used to study interactions of the material with blood platelets. The most important findings are: (a) the material is a genuine polymer with excellent X-ray visibility, even in the form of thin (0.4 mm) drawn fibres. This was established under realistic conditions. (b) The material exhibits low in vitro thrombogenicity, i.e. comparable to polyvinyl chloride, which is known as a passive material. These observations lead us to the suggestion that this type of radiopaque polymer holds promise with respect to application as a construction material for a new type of endovascular stent. This could be relevant in particular to stents to be used in conjunction with percutaneous transluminal coronary angioplasty (PTCA), also known as Dottering. Currently there is a clear trend away from metallic stents towards all-polymeric stents, since the latter have superior biocompatibility.(ABSTRACT TRUNCATED AT 250 WORDS)
Benzina
A
A
Biomaterials and Polymer Research Institute Maastricht-Eindhoven (Bioprime), University of Limburg, The Netherlands.
Kruft
M A
MA
Bär
F
F
van der Veen
F H
FH
Bastiaansen
C W
CW
Heijnen
V
V
Reutelingsperger
C
C
Koole
L H
LH
D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000378:metabolism*; D001807:Blood Vessel Prosthesis / Q000592:standards; D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion / Q000502:physiology; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D004548:Elasticity; D006801:Humans; D007463:Iodobenzoates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry*; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011108:Polymers; D015607:Stents
C092619:2-(4-iodobenzoyl)ethyl methacrylate; D001672:Biocompatible Materials; D003287:Contrast Media; D007463:Iodobenzoates; D008689:Methacrylates; D008768:Methylmethacrylates; D011108:Polymers; D020366:Methylmethacrylate; C005044:hydroxyethyl methacrylate; D004126:Dimethylformamide; D004121:Dimethyl Sulfoxide