Tissue and erythrocyte cholinesterase inhibition and protection by clinoptilolite pretreatment.
The inhibitory effect of VX, an organophosphate nerve agent, on tissue and erythrocyte cholinesterase (ChE) and the protective effect of clinoptilolite (Cli) in male Wistar rats were studied. The tissue and erythrocyte ChE activity were significantly inhibited 30 min after 65.5 micrograms VX/kg body weight administration. The greatest enzyme inhibition was observed in erythrocytes, stomach, brain and liver. The ChE activity after pretreatment with 1.0 g Cli/kg was significantly higher than that in the VX without Cli group in all samples except duodenum and colon.
Mojzis
J
J
Department of Pharmacology, Medical Faculty of Safarik University, Kosice, Slovak Republic.
Nistiar
F
F
Kovac
G
G
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D003106:Colon / Q000187:drug effects / Q000201:enzymology; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D006321:Heart / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013270:Stomach / Q000187:drug effects / Q000201:enzymology; D017641:Zeolites / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D017641:Zeolites; C083175:clinoptilolite; C009680:VX-agent