[DNA quantification and triploidy phenotype in the second and third trimesters of pregnancy].
Triploidy is often associated with early abortions, but may evolve during the second trimester taking a peculiar phenotype. The conditions of diagnosis or abortion do not always let the possibility of karyotyping. Thus, DNA quantification takes all its value. Twenty-three fetuses and placentas, ranging from 14 to 30 weeks of gestation with a phenotype of triploidy were analysed. Twelve cases were proved by karyotype. The DNA index studied in 6 of these was near 1.5, which confirmed the validity of the technique. Out of 11 phenotypes without karyotyping, DNA analysis identified 4 triploidies and a possible tetraploidy. So, a series of 16 cases could be collected, including 10 partial hydatidiform moles and 6 hypotrophic or normal fetuses and placentas.
Benoist
M
M
Laboratoire Pol Bouin, CHU Reims, Hôpital Maison Blanche.
Lorenzato
M
M
Doco
M
M
Pigeon
F
F
Lallemand
A
A
Gaillard
D
D
D000293:Adolescent; D000328:Adult; D004247:DNA / Q000032:analysis*; D005260:Female; D006801:Humans; D007621:Karyotyping; D010641:Phenotype; D011003:Ploidies; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D015203:Reproducibility of Results
D004247:DNA
Quantification de l'A.D.N. et phénotype de triploïdie aux deuxième et troisième trimestres de grossesse.