title: Cancer patients' decision making and trial-entry preferences: the effects of "framing" information about short-term toxicity and long-term survival.
abstract: The study purpose was to determine whether the framing of treatment information influenced patients' reported preferences for participating in treatment decision making and for trial entry. Ninety cancer patients read either neutrally-, positively-, or negatively-framed information about a chemotherapeutic treatment, then indicated their preferences for participating in the treatment decision, and whether they would participate in a clinical trial incorporating this protocol. There was no difference across information groups in preferences for participating in treatment decision making or willingness to enter such a clinical trial. Preference for participation in treatment decision making was significantly related to age (t = 2.54; p = 0.022), sex (x2 = 3.89; p = 0.05), and education (t = 2.54; p = 0.018); trial entry preferences were unrelated to these demographic variables. These results imply that, in this clinical context, attitudes towards participation in treatment decision making may be associated with characteristics of the patient, and attitudes towards trial entry may be dependent upon the clinical characteristics of a particular trial, but neither set of attitudes is influenced by the framing of protocol information.
authors.affiliation: Clinical Epidemiology Unit, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
authors.forename: H A
authors.initials: HA
authors.lastname: Llewellyn-Thomas
authors.forename: M J
authors.initials: MJ
authors.lastname: McGreal
authors.forename: E C
authors.initials: EC
authors.lastname: Thiel
mesh_terms: D017677:Age Distribution; D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000009:adverse effects; D002985:Clinical Protocols; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000401:mortality*; D003657:Decision Making; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D010358:Patient Participation; D016032:Randomized Controlled Trials as Topic; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000401:mortality*; D012107:Research Design; D017678:Sex Distribution; D011795:Surveys and Questionnaires; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents