Rapid assay of the anti-inflammatory activity of topical corticosteroids by inhibition of a UVA-induced neutrophil infiltration in hairless mouse skin. II. Assessment of name brand versus generic potency.
The hairless mouse model of a UVA-induced dermal neutrophilic infiltrate was used to compare the efficacy of equal concentrations of name brand versus generic corticosteroids. The generic brand was significantly less effective in suppressing the inflammatory response.
Kligman
L H
LH
University of Pennsylvania School of Medicine, Department of Dermatology, Philadelphia.
D000279:Administration, Cutaneous; D000818:Animals; D002465:Cell Movement; D003899:Desoximetasone / Q000494:pharmacology* / Q000627:therapeutic use*; D016568:Drugs, Generic; D051379:Mice; D008812:Mice, Hairless; D008954:Models, Biological; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000209:etiology; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D013810:Therapeutic Equivalency; D013997:Time Factors; D014466:Ultraviolet Rays
D016568:Drugs, Generic; D003899:Desoximetasone