title: [The solubility and bioequivalence of silymarin preparations].
abstract: Seven silymarin products (pharmacies only), two of them with two batches each, were analysed for their ingredients, in particular silibinin (CAS 22888-70-6) and tested in vitro for their liberation of active agents. Founded on the results of these tests three products were checked for bioequivalence. Therefore, a typical phase I 3 fold crossover study was performed showing one product (Legalon) to be qualified by an approx. 2 fold higher silibinin availability compared to the two other preparations.
authors.affiliation: LAFAA, Laboratory for Contract Research in Clinical Pharmacology and Biopharmaceutical Analytics GmbHa, Köln.
authors.forename: H U
authors.initials: HU
authors.lastname: Schulz
authors.forename: M
authors.initials: M
authors.lastname: Schürer
authors.forename: G
authors.initials: G
authors.lastname: Krumbiegel
authors.forename: W
authors.initials: W
authors.lastname: Wächter
authors.forename: R
authors.initials: R
authors.lastname: Weyhenmeyer
authors.forename: G
authors.initials: G
authors.lastname: Seidel
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D012838:Silymarin / Q000737:chemistry* / Q000493:pharmacokinetics*; D012995:Solubility; D013810:Therapeutic Equivalency
chemical_list: D012838:Silymarin
vernacular_title: Untersuchungen zum Freisetzungsverhalten und zur Bioäquivalenz von Silymarin-Präparaten.