Role of dendritic cells in benign and malignant lymphocytic infiltrates of the skin.
DC are members of a family of potent APCs located at the barriers of antigen entry into the human body. In the skin, much interest has been focused on epidermal DC (LC), and a considerable increase in knowledge about the function of those cells in normal and diseased skin has been achieved. Much less is known about the DC located in the dermis (DDC). The study of phenotype and function of this heterogeneous cell population became possible by recent progress in the development of a reproducible isolation schema. This review provides a summary of our recent data regarding the role of DDC in normal human skin and also presents some data about their role in psoriasis. Furthermore, a four-step model of the pathogenesis of CTCL is presented, which integrates recently acquired knowledge about this disease and proposes a central role for DDC in crucial steps for the development of this lymphoproliferative disease.
Nestle
F O
FO
Department of Pathology, University of Michigan Medical School, Ann Arbor.
Nickoloff
B J
BJ
D017951:Antigen Presentation; D015815:Cell Adhesion Molecules / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007694:Killer Cells, Natural / Q000502:physiology; D008214:Lymphocytes / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000473:pathology*; D012867:Skin / Q000166:cytology* / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology*
D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1