Small, dense low-density lipoprotein as a risk factor for coronary heart disease.
Data from case-control and cross-sectional studies uniformly demonstrate an association between small, dense low-density lipoprotein and risk of coronary heart disease. This relationship may be attributable to the association of small, dense low-density lipoprotein with other atherogenic lipoproteins, the presence of the insulin resistance syndrome in subjects with small low-density lipoprotein, and/or the increased oxidative susceptibility of small, dense low-density lipoprotein particles. Furthermore, because small low-density lipoprotein appears to be a common trait in the general population, more than one of these atherogenic mechanisms may be operating simultaneously to increase risk of coronary heart disease.
Austin
M A
MA
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
D000328:Adult; D016022:Case-Control Studies; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008077:Lipoproteins, LDL / Q000009:adverse effects* / Q000737:chemistry / Q000145:classification; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012307:Risk Factors
D008077:Lipoproteins, LDL