[Hematologic remission and disappearance of hemolytic anemia in chronic lymphocytic leukemia after therapy with 2-chlorodeoxyadenosine (2-CDA)].
A 62 yr old patient with CLL (Binet C) with severe hemolytic anemia, resistant to conventional immunosuppressive treatment (cyclophosphamide, azathioprine, steroids) had been treated with two cycles of 2-CDA. The therapy resulted in the decrease of leukocyte count (even below 1000/microliters), with subsequent recovery of fairly normal granulopoiesis, eradication of lymphocyte infiltration of the bone marrow, and inhibition of the autoimmune phenomena.
Piatkowska-Jakubas
B
B
Kliniki Hematologii Collegium Medicum UJ, Krakowie.
Skotnicki
A B
AB
D000743:Anemia, Hemolytic / Q000188:drug therapy* / Q000209:etiology; D001327:Autoimmune Diseases / Q000188:drug therapy*; D017338:Cladribine / Q000627:therapeutic use*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
D017338:Cladribine
Remisja hematologiczna oraz ustapienie niedokrwistości hemolitycznej u chorego z białaczka limfocytowa przewlekła w nastepstwie terapii 2-chlorodeoksyadenozyna (2-CDA).