title: 7-(Disubstituted thiazolyl)-3,5-dihydroxy-6-heptenoic/heptanoic acid derivatives as HMG-CoA reductase inhibitors.
abstract: A series of disubstituted thiazoles, functionalized with the essential 3,5-dihydroxy-6-heptenoic or heptanoic chain, were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. All the synthesized compounds 46-61 showed a moderate inhibitory potency.
authors.affiliation: Istituto di Chimica Farmaceutica e Tecnia Farmaceutica, Università di Perugia, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Cecchetti
authors.forename: A
authors.initials: A
authors.lastname: Fravolini
authors.forename: P G
authors.initials: PG
authors.lastname: Pagella
authors.forename: O
authors.initials: O
authors.lastname: Tabarrini
authors.forename: A
authors.initials: A
authors.lastname: Temperini
mesh_terms: D000818:Animals; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013844:Thiazoles