Sleep pattern and supplementary oxygen requirements in infants with chronic neonatal lung disease.
Seven infants with chronic neonatal lung disease and baseline oxygen saturation greater than 90% were studied with overnight polysomnography in their prescribed oxygen environment, and on a second night with 0.25 L/min additional oxygen. All had sleep fragmentation and decreased rapid-eye-movement (REM) sleep, which was reversed after the increased oxygen. Sleep duration (p < 0.003), percentage REM sleep (p < 0.001), and mean REM sleep period length (p < 0.001) were increased, and arousals in REM sleep decreased (p < 0.05), with improved oxygenation. We conclude that, in infants with chronic neonatal lung disease, arousal mechanisms minimise oxygen desaturation but induce sleep disruption.
Harris
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MA
National SIDS Council, David Read Paediatric Sleep Disorders Centre, Royal Alexandra Hospital for Children, Sydney, Australia.
Sullivan
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CE
D001143:Arousal; D001785:Blood Gas Monitoring, Transcutaneous; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology / Q000628:therapy; D002908:Chronic Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008171:Lung Diseases / Q000503:physiopathology / Q000628:therapy*; D010102:Oxygen Inhalation Therapy; D017286:Polysomnography; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology