3-Acetylpyridine neurotoxicity to the nigrostriatal dopamine system in mice.
Employing tyrosine hydroxylase (TH) immunohistochemistry, the neurotoxic effects of 3-acetylpyridine (3-AP), a potent neurotoxin selective to olivocerebellar climbing fibers, on the mesencephalic dopamine systems were investigated in mice. Systemic injections of 3-AP resulted in a large loss of TH-immunoreactive nigrostriatal neurons. On the other hand, 3-AP neurotoxicity to the mesolimbic dopamine system was much less drastic. The 3-AP-induced concurrent loss of olivocerebellar and nigrostriatal neurons may replicate an essential neuropathological feature of olivopontocerebellar atrophy-associated parkinsonism.
Takada
M
M
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee at Memphis 38163.
Kono
T
T
D000818:Animals; D003342:Corpus Striatum / Q000473:pathology*; D004298:Dopamine / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009411:Nerve Endings / Q000187:drug effects / Q000201:enzymology; D009412:Nerve Fibers / Q000187:drug effects / Q000201:enzymology; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D011725:Pyridines / Q000633:toxicity*; D013378:Substantia Nigra / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology / Q000378:metabolism
D011725:Pyridines; C010835:3-acetylpyridine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine