Effects of barriers on propagation of action potentials in two-dimensional cardiac tissue. A computer simulation study.
A two-dimensional anisotropic model of cardiac ventricular muscle was used to study the effects of discontinuities (barriers), such as dead cells or high-resistance areas, on longitudinal plane-wave propagation. Problems in propagation appear when long barriers become thicker and their spacing closer. Short barriers with large widths and small spacing also cause propagation disturbances and significant delays in their vicinity. If the plane wave front propagates through the barriers, the velocity returns to near normal within one-length constant away from the end of the barrier region. For a funnel-like structure, an opening of 13 cells should exist for longitudinal plane wave propagation. For smaller openings, the ratio of openings required for propagation to occur when traveling from a narrow to a wider area of tissue is proportional to the anisotropy ratio, which can cause unidirectional block. Tortuosity, created by spatial distribution of dead cell barriers, can facilitate propagation by changing the effective impedance the wave front sees, and can create multiple local delays, which may result in discrepancies when measuring propagation velocity.
Maglaveras
N
N
Aristotelian University of Thessaloniki, Macedonia, Greece.
Offner
F
F
van Capelle
F J
FJ
Allessie
M A
MA
Sahakian
A V
AV
D000200:Action Potentials / Q000502:physiology*; D016923:Cell Death; D002462:Cell Membrane / Q000502:physiology; D003198:Computer Simulation; D003593:Cytoplasm / Q000502:physiology; D004553:Electric Conductivity; D017097:Electric Impedance; D004562:Electrocardiography; D006321:Heart / Q000502:physiology*; D006327:Heart Block / Q000503:physiopathology; D006329:Heart Conduction System / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D013997:Time Factors