title: A comparison of long term results of the standard Whipple procedure and the pylorus preserving pancreatoduodenectomy.
abstract: The standard Whipple procedure involves intestinal disturbances, such as dumping, diarrhea, dyspeptic complaints and the occurrence of ulcers of the anastomoses. A postoperative weight loss was observed ranging between 10 and 40 kilograms. Only a few patients were able to compensate after several months. It was thought that preservation of the intact stomach would prevent the complications arising from a loss of gastric reservoir function and thus the malnutrition could be improved postoperatively. Between 1985 and March 1992, we performed the pylorus-preserving Whipple procedure and treated a group of 43 patients with this method. In the same period, 15 patients were operated upon with the standard Whipple procedure. The present evaluation of the accumulated patient data, including extensive functional studies, led to the following results comparing the pylorus preserving Whipple procedure with the standard Whipple procedure. First, the capacity for food uptake and the development of body weight postoperatively is significantly better. Second, gastric or jejunal ulcers were not observed. Third, there were no clinical signs of digestive disorders, such as different forms of dumping. Nutrition and digestion were not impeded by the preserved opening mechanism of the pylorus. Fourth, the postoperative exocrine function was only slightly decreased. Fifth, glucose metabolism postoperatively was influenced only slightly by preservation of the pylorus. In taking the results of all the examinations into consideration, it can be said that the restricted organ loss in the Whipple procedure with pylorus preservation leaves the secretory and functional capacity of the upper part of the gastrointestinal tract almost unchanged.
authors.affiliation: Surgical Clinic, Ruhr University Bochum, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Kozuschek
authors.forename: H B
authors.initials: HB
authors.lastname: Reith
authors.forename: H
authors.initials: H
authors.lastname: Waleczek
authors.forename: W
authors.initials: W
authors.lastname: Haarmann
authors.forename: M
authors.initials: M
authors.lastname: Edelmann
authors.forename: D
authors.initials: D
authors.lastname: Sonntag
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000601:surgery*; D002276:Carcinoid Tumor / Q000601:surgery; D018273:Carcinoma, Islet Cell / Q000601:surgery; D004379:Duodenal Neoplasms / Q000601:surgery*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome