Bilateral acetylsulfapyridine nephrolithiasis associated with chronic sulfasalazine therapy.
We report on formation of bilateral renal calculi secondary to sulfasalazine therapy for juvenile rheumatoid arthritis. The condition was successfully treated with extracorporeal shock wave lithotripsy. Analysis of the fragments with thin layer chromatography and nuclear magnetic resonance revealed acetylsulfapyridine, a metabolite of sulfasalazine.
Erturk
E
E
Department of Urology, University of Rochester, New York 14642.
Casemento
J B
JB
Guertin
K R
KR
Kende
A S
AS
D000328:Adult; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced* / Q000737:chemistry / Q000378:metabolism; D013427:Sulfapyridine / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D012460:Sulfasalazine / Q000009:adverse effects* / Q000378:metabolism
C005377:N-acetylsulfapyridine; D012460:Sulfasalazine; D013427:Sulfapyridine