title: Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection.
abstract: A 42-year-old Japanese man with chronic active Epstein-Barr virus (EBV) infection initially responded to treatment with interleukin-2 (IL-2). Six months later he developed thrombosis in the hepatic veins, and Budd-Chiari syndrome associated with severe hepatic damage was diagnosed. He also developed a solitary EBV-positive plasmacytoma in the right femur. Since these rare complications occurred after long-term IL-2 therapy, the possibility that long-term IL-2 therapy might cause Budd-Chiari syndrome and liver damage as well as EBV-associated plasmacytoma is discussed.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nagafuchi
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi
authors.forename: K
authors.initials: K
authors.lastname: Anzai
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
authors.forename: Y
authors.initials: Y
authors.lastname: Ohno
authors.forename: N
authors.initials: N
authors.lastname: Fukushima
authors.forename: M
authors.initials: M
authors.lastname: Hashizume
authors.forename: K
authors.initials: K
authors.lastname: Sugimachi
authors.forename: H
authors.initials: H
authors.lastname: Chuman
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D006502:Budd-Chiari Syndrome / Q000139:chemically induced*; D002908:Chronic Disease; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D008297:Male; D010954:Plasmacytoma / Q000139:chemically induced* / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications*
chemical_list: D007376:Interleukin-2