[Tetraplegia after colonoscopy: benzodiazepine withdrawal syndrome induced by flumazenil?].
A case is reported of a 68-year-old female patient who developed a flaccid tetraplegia on recovering from a colonoscopy, carried out under general anaesthesia (3 mg of midazolam, 20 mg of etomidate). During the preanaesthetic visit, she omitted to report a 15-year-addiction to lorazepam 2.5 mg every night. At the end of the procedure, 0.2 mg of flumazenil were injected. Recovery was immediate but followed by neurological signs associating general weakness, paraesthesia and tetraplegia. These symptoms discontinued spontaneously two hours later. She was discharged the same day but complained of myalgia and paraesthesia for a week. The physiopathology of this accident is unknown. The differential diagnosis and the influence of flumazenil on benzodiazepine withdrawal are discussed.
Sleth
J C
JC
Département d'Anesthésie-Réanimation, CHG de Béziers.
Duhamel
O
O
D000368:Aged; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D003113:Colonoscopy / Q000009:adverse effects*; D005260:Female; D005442:Flumazenil / Q000009:adverse effects*; D006801:Humans; D011782:Quadriplegia / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome
D014151:Anti-Anxiety Agents; D005442:Flumazenil
Tétraplégie au décours d'une colonoscopie: syndrome de sevrage aux benzodiazépines induit par le flumazénil?