title: Prolactin secretion following repetitive seizures.
abstract: We studied serum prolactin levels after 24 seizures occurring in eight subjects. Video-EEG intracranial monitoring confirmed temporal or frontal partial seizures. Seizure type, focus, and duration were similar for seizures with and without significant postictal prolactin elevations. The seizure-free interval (the time between seizures) varied considerably. Seizures occurring after longer seizure-free intervals (31.75 to 240 hours) showed robust prolactin responses. After shorter seizure-free intervals (1.07 to 25.42 hours), prolactin responses were reduced. This suggests that the amount of releasable prolactin is limited, depleted by seizures, or perhaps inhibited by prolactin feedback. Seizure-free intervals should be considered when interpreting prolactin levels.
authors.affiliation: Department of Neurology, Mid-Atlantic Regional Epilepsy Center, Medical College of Pennsylvania, Philadelphia 19129.
authors.forename: D E
authors.initials: DE
authors.lastname: Malkowicz
authors.forename: A
authors.initials: A
authors.lastname: Legido
authors.forename: R A
authors.initials: RA
authors.lastname: Jackel
authors.forename: N M
authors.initials: NM
authors.lastname: Sussman
authors.forename: B A
authors.initials: BA
authors.lastname: Eskin
authors.forename: R N
authors.initials: RN
authors.lastname: Harner
mesh_terms: D000328:Adult; D002648:Child; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000097:blood / Q000503:physiopathology*; D004833:Epilepsy, Temporal Lobe / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood* / Q000378:metabolism; D012008:Recurrence
chemical_list: D011388:Prolactin