title: Reversible ADP-ribosylation as a mechanism of enzyme regulation in procaryotes.
abstract: Several cases of ADP-ribosylation of endogenous proteins in procaryotes have been discovered and investigated. The most thoroughly studied example is the reversible ADP-ribosylation of the dinitrogenase reductase from the photosynthetic bacterium Rhodospirillum rubrum and related bacteria. A dinitrogenase reductase ADP-ribosyltransferase (DRAT) and a dinitrogenase reductase ADP-ribose glycohydrolase (DRAG) from R. rubrum have been isolated and characterized. The genes for these proteins have been isolated and sequences and show little similarity to the ADP-ribosylating toxins. Other targets for endogenous ADP-ribosylation by procaryotes include glutamine synthetase in R. rubrum and Rhizobium meliloti and undefined proteins in Streptomyces griseus and Pseudomonas maltophila.
authors.affiliation: Department of Biochemistry, University of Wisconsin, Madison 53706.
authors.forename: P W
authors.initials: PW
authors.lastname: Ludden
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D009591:Nitrogenase / Q000378:metabolism
chemical_list: D000246:Adenosine Diphosphate Ribose; D009591:Nitrogenase; D005974:Glutamate-Ammonia Ligase