[Neurotransmitter balance in the CNS structure as effected by the combination of ionizing radiation and various doses of lead acetate].
In experiments with mature Wistar male rats exposed to 25- and 50-fold fractionated doses of external X-ray radiation (0.5 Gy) and daily probe-assisted administration of plumbum acetate (100, 10, 5 mg/kg), similar, but differently marked changes in transmitter relationship in some CNS structures resembling the earlier found neurotransmitter disbalance during chronic stress of different ethiology were revealed. Combined exposure to plumbum and radiation led to more sustained and prolonged disorders to transmitter relationship associated with a sharp decrease in specific binding of corticosterone in CNS glucocorticoid-sensitive structures.
Gurin
V N
VN
Dudina
T V
TV
Elkina
A I
AI
Kandybo
T S
TS
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D003345:Corticosterone / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007854:Lead / Q000494:pharmacology*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism* / Q000528:radiation effects; D009942:Organometallic Compounds / Q000494:pharmacology*; D011485:Protein Binding; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D014965:X-Rays
D018377:Neurotransmitter Agents; D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate; D003345:Corticosterone
Neĭromediatornyĭ balans v strukturakh TsNS pri sochetannom vozdeĭstvii ioniziruiushcheĭ radiatsii i razlichnykh doz atsetata svintsa.