Effect of chloroquine on rat liver mitochondria.
Chloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy.
Deepalakshmi
P D
PD
Department of Biochemistry, University of Madras, India.
Parasakthy
K
K
Shanthi
S
S
Devaraj
N S
NS
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D002738:Chloroquine