A differential-avidity model for T-cell selection.
The processes of positive and negative selection during thymic development shape the repertoires of antigen specificities displayed by T cells. This rids the animal of potentially autoreactive T cells and, at the same time, ensures that they are capable of major histocompatibility complex (MHC)-restricted recognition of antigen. Paradoxically, both processes involve the engagement of the T-cell recepetor (TCR) on immature thymocytes with peptide/MHC complexes expressed on thymic stromal cells. Here, Philip Ashton-Rickardt and Susumu Tonegawa suggest that the critical parameter determining the outcome of this interaction is the number of TCRs occupied by peptide/MHC complexes and that this, in turn, is determined by the avidity of the TCR-MHC interaction: low avidity resulting in positive selection and high avidity resulting in negative selection.
Ashton-Rickardt
P G
PG
Dept of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Tonegawa
S
S
D000818:Animals; D002454:Cell Differentiation; D008285:Major Histocompatibility Complex / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology
D011948:Receptors, Antigen, T-Cell