Influence of coenzyme Q-10 on the hypotensive effects of enalapril and nitrendipine in spontaneously hypertensive rats.
Administration of coenzyme Q-10 (10 mg/kg) once a day for 4 weeks decreased the arterial blood pressure in SHR's. Enalapril and nitrendipine administered in a single dose caused significant decrease of blood pressure. Application of enalapril and nitrendipine to rats chronically pretreated with coenzyme Q-10 revealed, that the maximal hypotensive effect was not greater, but it lasted much (ca. 2-times) longer. Independently of mechanism of this interaction it may be suggested that the chronic administration of coenzyme Q-10 would create the possibility of significant decrease of the frequency of some antihypertensive drug administration.
Danysz
A
A
Department of Pharmacology, Pharmaceutical Research Institute Rydygiera, Warszawa, Poland.
Oledzka
K
K
Bukowska-Kiliszek
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003067:Coenzymes; D004195:Disease Models, Animal; D004357:Drug Synergism; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006973:Hypertension / Q000188:drug therapy*; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D009568:Nitrendipine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D003067:Coenzymes; D014451:Ubiquinone; D004656:Enalapril; D009568:Nitrendipine; C024989:coenzyme Q10