title: Biochemical studies of inherited diseases related to abnormal cholesterol metabolism. I. High-performance liquid chromatographic analysis of bile alcohol glucuronides in cerebrotendinous xanthomatosis.
abstract: We developed a rapid and simple quantitative method for measuring bile alcohol glucuronides in serum involving high-performance liquid chromatography without group separation and hydrolysis. The assay of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol 3-glucuronide, the major bile alcohol component in serum from cerebrotendinous xanthomatosis patients, with the present method was useful for the diagnosis of cerebrotendinous xanthomatosis.
authors.affiliation: Department of Surgery 1, Kyushu University School of Medicine, Fukuoka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ohshima
authors.forename: T
authors.initials: T
authors.lastname: Kuramoto
authors.forename: T
authors.initials: T
authors.lastname: Hoshita
mesh_terms: D002777:Cholestanols / Q000097:blood*; D002784:Cholesterol / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005965:Glucuronates / Q000097:blood*; D006801:Humans; D007202:Indicators and Reagents; D008052:Lipid Metabolism, Inborn Errors / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D014973:Xanthomatosis / Q000097:blood / Q000175:diagnosis*
chemical_list: D002777:Cholestanols; D005965:Glucuronates; D007202:Indicators and Reagents; C020262:cholestane-3,7,12,26-tetrol; D002784:Cholesterol