Pressure-induced disorders in neurotransmission and spontaneous behavior in rats: an animal model of psychosis.
Disorders in neurotransmission and spontaneous behavior in rats exposed to a high pressure helium-oxygen mixture that shows interesting parallels with the dopaminergic hypothesis of schizophrenia at both the biochemical and the therapeutic responding levels are reviewed. Furthermore, as human subjects exposed to a very high pressure have shown psychotic episodes, we conclude that the pressure-induced disorders in neurotransmission and spontaneous behavior in rats could constitute a valid animal model of schizophreniform psychosis and a useful tool for both the investigation of the biological mechanisms underlying schizophrenia and the development of new antipsychotic drugs.
Abraini
J H
JH
Unité de Neuropsychiatrie, C.H.U. Sart Tilman, Liège, Belgium.
Ansseau
M
M
Fechtali
T
T
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D002421:Caudate Nucleus / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D006371:Helium; D006610:High Pressure Neurological Syndrome / Q000503:physiopathology*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D019965:Neurocognitive Disorders / Q000503:physiopathology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000503:physiopathology; D010100:Oxygen; D011699:Putamen / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology*
D014150:Antipsychotic Agents; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D006371:Helium; D010100:Oxygen; D004298:Dopamine