title: Exclusion of linkage between manic depressive illness and tyrosine hydroxylase and dopamine D2 receptor genes.
abstract: Mutations at the tyrosine hydroxylase or dopamine D2 receptor loci causing manic depressive illness are unlikely in two families reported here. Linkage was excluded for both loci assuming a dominant mode of transmission and for the tyrosine hydroxylase locus also assuming a recessive mode of transmission. The exclusion was significant using models based on severity of psychopathology and a model requiring severe illness also in first-degree relatives. Conservative genetic parameters were used to minimize misclassification.
authors.affiliation: Institute of Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Ewald
authors.forename: O
authors.initials: O
authors.lastname: Mors
authors.forename: U
authors.initials: U
authors.lastname: Friedrich
authors.forename: T
authors.initials: T
authors.lastname: Flint
authors.forename: T
authors.initials: T
authors.lastname: Kruse
mesh_terms: D000483:Alleles; D001483:Base Sequence; D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D017448:Receptors, Dopamine D2; D014446:Tyrosine 3-Monooxygenase