title: Urine concentrating ability after prolonged sevoflurane anaesthesia.
abstract: Few studies have used the vasopressin test to evaluate urine concentrating ability after sevoflurane anaesthesia. We performed a vasopressin test on the first day after operation to compare the effect of prolonged sevoflurane anaesthesia for orthopaedic procedures (n = 11) with that of isoflurane (n = 10). Mean doses of sevoflurane and isoflurane were 10.6 (SE 0.9) and 8.5 (1.5) MAC-h, respectively. Mean peak serum fluoride concentration in patients anaesthetized with sevoflurane was 41.9 (2.5 mumol litre-1 and exceeded 20 mumol litre-1 for approximately 20 h. Each group showed similar responses to vasopressin. There was no evidence of subclinical nephrotoxicity in patients given prolonged sevoflurane anaesthesia.
authors.affiliation: Department of Anaesthesiology, National Defense Medical College, Saitama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Higuchi
authors.forename: S
authors.initials: S
authors.lastname: Arimura
authors.forename: H
authors.initials: H
authors.lastname: Sumikura
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Kanno
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D000777:Anesthetics; D004987:Ethers; D006801:Humans; D007530:Isoflurane; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D009994:Osmolar Concentration; D000077149:Sevoflurane; D014556:Urine / Q000737:chemistry*; D014667:Vasopressins
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D014667:Vasopressins; D000077149:Sevoflurane; D007530:Isoflurane