title: Prolonged neuromuscular blockade for relaxation in two pediatric intensive care patients.
abstract: Newer neuromuscular blocking drugs provide optimum blockade and can facilitate ventilation, yet if they are discontinued, they allow predictable reversal. This article documents the use of these drugs in the treatment of two pediatric intensive care unit patients who had different physiologic problems and pharmacologic needs and who were ventilator dependent for a prolonged period. In each case, neuromuscular blockade significantly facilitated ventilation and allowed time for treatment of the underlying pathology without deleterious pharmacologic side effects resulting in a favorable outcome for both patients. The article discusses some of the unique pharmacologic properties of these drugs and the rationale for their use.
authors.affiliation: Department of Anesthesiology, University of Florida College of Medicine, Gainesville 32610-0254.
authors.forename: J
authors.initials: J
authors.lastname: Koska
authors.forename: L S
authors.initials: LS
authors.lastname: Berman
mesh_terms: D000293:Adolescent; D002648:Child; D003422:Critical Care; D006801:Humans; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D012121:Respiration, Artificial / Q000379:methods*; D013997:Time Factors; D014673:Vecuronium Bromide / Q000627:therapeutic use*
chemical_list: D014673:Vecuronium Bromide