title: Is there any specific personality disorder or personality disorder cluster that worsens the short-term treatment outcome of major depression?
abstract: This study attempted to identify a specific personality disorder (PD) or PD cluster that independently worsens the 4-month treatment outcome of major depression under adequate antidepressant. The material of the study was 96 consecutive outpatients with major depression. For the Axis I and Axis II diagnoses, the Structured Clinical Interview for DSM-III-R (SCID) was used. In the material, the presence of any PD significantly worsened the 4-month outcome. The discriminant function analysis, conducted to identify a specific PD or PD cluster that influences the outcome, found that the number of PD from only cluster A and the number of criteria met for only schizoid PD was significantly correlated with the 4-month outcome of depression.
authors.affiliation: Department of Psychiatry, Nijgata City General Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Sakado
authors.forename: S
authors.initials: S
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D000928:Antidepressive Agents / Q000008:administration & dosage*; D001569:Benzodiazepines; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000008:administration & dosage*; D008728:Methotrimeprazine / Q000008:administration & dosage; D008803:Mianserin / Q000008:administration & dosage / Q000031:analogs & derivatives; D008875:Middle Aged; D010552:Personality Assessment; D010554:Personality Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D013469:Sulpiride / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001569:Benzodiazepines; D008803:Mianserin; D008376:Maprotiline; C050605:setiptiline; D013469:Sulpiride; D008728:Methotrimeprazine