title: [Mivazerol and other benzylimidazoles with alpha-2 adrenergic properties].
abstract: 4-Benzyl-imidazole compounds derived from Salbutanol are evaluated for potential adrenergic activities. The prevalent property of a series of new bioisosteres of catecholamines either of the saligenol-(ucb LO61) or benzamide-(Mivazerol) type is a selective alpha-adrenergic agonism, at the presynaptic level. The present study stresses the structural features responsible for the alpha-2-agonistic property.
authors.affiliation: Département de Recherche Chimique, R&D, UCB S.A. Secteur Pharmaceutique Chemin du Foriest, Belgique.
authors.forename: E
authors.initials: E
authors.lastname: Cossement
authors.forename: J P
authors.initials: JP
authors.lastname: Geerts
authors.forename: P
authors.initials: P
authors.lastname: Michel
authors.forename: G
authors.initials: G
authors.lastname: Motte
authors.forename: M
authors.initials: M
authors.lastname: Noyer
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D006168:Guinea Pigs; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D001562:Benzimidazoles; D007093:Imidazoles; D018341:Receptors, Adrenergic, alpha-2; C087969:mivazerol
vernacular_title: Mivazerol et autres benzylimidazoles á properiétés alpha-2 adrénergiques.