Single dose tinidazole prophylaxis in vaginal hysterectomy.
OBJECTIVE
To determine the efficacy and side effects of a single dose of tinidazole for infection following vaginal hysterectomy.


METHODS
A randomized double-blind placebo-controlled trial using 2 g tinidazole 12 h before vaginal hysterectomy in 50 patients was conducted. No other antibiotic was used until the development of infection.


RESULTS
There was a significant reduction (P < 0.01) of post-operative vaginal cuff cellulitis (54-16%). A similar reduction (P < 0.05) in febrile morbidity was also observed. The duration of postoperative hospital stay (P < 0.001) and use of additional antibiotics (P < 0.01) were also reduced. No adverse effect of tinidazole was noted.


CONCLUSIONS
A single dose of tinidazole appears to be a safe and effective alternative prevention against infection in vaginal hysterectomy.
Dhar
K K
KK
Department of Obstetrics & Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Dhall
G I
GI
Ayyagari
A
A
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007045:Hysterectomy, Vaginal; D008875:Middle Aged; D009017:Morbidity; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D014011:Tinidazole / Q000008:administration & dosage*
D014011:Tinidazole