[Age-related features of neurohumoral regulation of somatotropic hormone secretion].
Experiments with primary cultures demonstrated a stimulating effect of TRF on somatotropic hormone (STH) secretion by hypophyseocytes of neonatal but not adult rats and a reduced reactivity of neonatal somatotrophs to the inhibitory effect of somatostatin during short-term incubation. No noticeable serotonin effect on STH release from hypophyseal cells of animals of various ages was observed. During prolonged (24 h) incubation a weak inhibitory effect of bromocriptine and melatonin on STH secretion by pituitary cells of neonatal but not adult rats was observed. These results permit us propose a similarity of the functional characteristics of neonatal pituitary somatotrophs to somatomammotroph properties.
Galstian
G R
GR
Starostina
E G
EG
Dedov
I I
II
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D018377:Neurotransmitter Agents; D012701:Serotonin; D001971:Bromocriptine; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone; D008550:Melatonin
Vozrastnye osobennosti neĭrogumoral'noĭ reguliatsii sekretsii somatotropnogo gormona.