Disposition of enantiomers of sultopride in a human, rats and rabbits.
Pharmacokinetics of sultopride enantiomers was examined following a single dose in a human, rabbits and rats. Pharmacokinetic profiles were similar between (+)- and (-)-enantiomers of sultopride in human, whereas the serum concentrations of (-)-sultopride were slightly higher than those of (+)-sultopride after i.v. administration of 50 mg/kg of racemic sultopride to rats and rabbits.
Kamizono
A
A
Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.
Inotsume
N
N
Fukushima
S
S
Nakano
M
M
D000077582:Amisulpride; D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013469:Sulpiride / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine
D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride