Increased frequency of the S allele of the L-myc oncogene in non-Hodgkin's lymphoma.
We studied 100 patients with non-Hodgkin's lymphoma, 44 patients with Hodgkin's disease and 100 controls for the prevalence of the EcoRI restriction fragment polymorphism of the L-myc oncogene. No difference in the frequency of the three genotypes (LL, LS, SS) was found between the patient and control groups. However, the S allele was found to occur more frequently in the non-Hodgkin's lymphoma patients (chi 2 = 4.57, P = 0.032). These data confirm an earlier report and suggest that the presence of the S allele is associated with susceptibility to non-Hodgkin's lymphoma.
Crossen
P E
PE
Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.
Morrison
M J
MJ
Colls
B M
BM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000032:analysis; D015246:Deoxyribonuclease EcoRI; D005260:Female; D005787:Gene Frequency; D016259:Genes, myc / Q000235:genetics*; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
D015342:DNA Probes; D004273:DNA, Neoplasm; D015246:Deoxyribonuclease EcoRI