[The effect of fenazepam and phenobarbital administered prenatally and in the early postnatal period on the behavioral reactions of rat progeny].
Phenazepam, 10 mg/kg/day, or phenobarbital, 30 mg/kg/day, administered to female rats during the entire pregnancy and 5 days after delivery during lactation induced behavioral changes in their offsprings at early (1.5-2 months) and later (4 months) ages. Phenobarbital produced a more marked effect on the central nervous system than phenazepam by causing impairments of extrapolatory reflexes and behavioral stereotype in a conflict situation or open field.
Chobanov
N G
NG
Voronina
T A
TA
Liubimov
B I
BI
D000375:Aging / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects; D003220:Conflict, Psychological; D004644:Emotions / Q000187:drug effects; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D010634:Phenobarbital
Vliianie fenazepama i fenobarbitala, vvodimykh v prenatal'nom i rannem postnatal'nom periodakh, na povedencheskie reaktsii potomstva krys.