Protection against cisplatin lethality and renal toxicity by chlorpromazine in mice.
The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine (i.p.) given 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin, while chlorpromazine did not reduce the antitumor activity of cisplatin against sarcoma 180 in ddY mice or El-4 leukemia in C57BL/6J mice.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Ozaki
M
M
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D007668:Kidney / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009584:Nitrogen / Q000652:urine; D051437:Renal Insufficiency / Q000139:chemically induced / Q000517:prevention & control*; D012510:Sarcoma 180 / Q000188:drug therapy
D009584:Nitrogen; D002945:Cisplatin; D002746:Chlorpromazine