An unreported RFLP for probe 218 EP6 that is useful in linkage analysis of adult polycystic kidney disease.
Probe 218 EP6 is known to recognise two restriction fragment length polymorphisms (RFLPs) after digestion of genomic DNA with PvuII. We report a rare allele that segregates in Mendelian fashion, in a family where adult polycystic kidney disease was being tracked using linked polymorphisms.
Jeffery
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S
S.W. Thames Genetic Unit, St George's Hospital Medical School, London, UK.
Morgan
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S
D000483:Alleles; D002885:Chromosomes, Human, Pair 16; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D015342:DNA Probes; D004247:DNA