[The relationship of the restriction fragment length polymorphism of the apo-B gene to the blood lipid spectrum in patients with ischemic heart disease].
Restriction fragment length polymorphism of the apo-B gene at the Xbal restriction site was detected. The association between RFLP of the apo-B gene and the level of lipid metabolism indices was revealed. The levels of total cholesterol LDLP CH and atherogenicity coefficient were significantly higher in homozygotes with this restriction site (X2X2) than in homozygotes X1X1 and heterozygotes.
Tseluĭko
V I
VI
Kravchenko
N A
NA
Shut'
I V
IV
Cherkashina
V I
VI
D000328:Adult; D001055:Apolipoproteins B / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2; D004247:DNA / Q000097:blood; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D017202:Myocardial Ischemia / Q000097:blood* / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
D001055:Apolipoproteins B; D008055:Lipids; D004247:DNA
Sviaz' polimorfizma dliny restriktsionnykh fragmentov gena apo-B s lipidnym spektrom krovi u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.