title: The relationship between mixed venous and hepatic venous O2 saturation in patients with septic shock.
abstract: It was the purpose of this study to measure the relationship between hepatic venous O2 saturation (ShvO2) and mixed venous O2 saturation (SvO2) in septic patients (n = 21) following treatment with various catecholamines (epinephrine, norepinephrine, dopamine, dopexamine). At baseline mean SvO2 was 74 +/- 5% while mean ShvO2 was 59 +/- 12%. Alpha-mimetic substances such as epinephrine and norepinephrine reduced ShvO2 and increased the difference between SvO2 and ShvO2.Beta2-mimetic and dopaminergic substances (dopexamine, dopamine) did not change the difference between SvO2 and ShvO2. These results show that SvO2 does not necessarily reflect all changes of ShvO2. Monitoring ShvO2 may be helpful in managing septic shock by adding information on adequacy of O2 supply/consumption ratio in the crucial splanchnic region.
authors.affiliation: Department of Anesthesiology and Surgical Intensive Care Medicine, Steglitz Medical Center, Free University of Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Meier-Hellmann
authors.forename: L
authors.initials: L
authors.lastname: Hannemann
authors.forename: M
authors.initials: M
authors.lastname: Specht
authors.forename: W
authors.initials: W
authors.lastname: Schaffartzik
authors.forename: C
authors.initials: C
authors.lastname: Spies
authors.forename: K
authors.initials: K
authors.lastname: Reinhart
mesh_terms: D004280:Dobutamine / Q000494:pharmacology; D004298:Dopamine / Q000031:analogs & derivatives / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006503:Hepatic Veins; D006801:Humans; D009638:Norepinephrine / Q000494:pharmacology; D010100:Oxygen / Q000097:blood* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D012772:Shock, Septic / Q000097:blood*; D013152:Splanchnic Circulation / Q000187:drug effects; D014680:Veins
chemical_list: D015259:Dopamine Agents; C046318:dopexamine; D004280:Dobutamine; D010100:Oxygen; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine