title: Physiology of the APUD system.
abstract: The characteristic biochemical pathway of the APUDoma cell, namely amine precursor uptake and decarboxylation, are illustrated by the examples of serotonin and catecholamine metabolism. Increasing understanding of the origins of APUDomas as well as the biochemistry and physiology of the hormones they produce, has led to improved methods of detection, imaging and treatment of afflicted patients.
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: M J
authors.initials: MJ
authors.lastname: Demeure
mesh_terms: D001078:APUD Cells / Q000502:physiology*; D000310:Adrenal Gland Neoplasms; D001079:Apudoma; D002395:Catecholamines / Q000378:metabolism*; D015408:Gastrinoma; D006801:Humans; D009490:Neurosecretory Systems / Q000502:physiology*; D010673:Pheochromocytoma; D012701:Serotonin / Q000378:metabolism*; D013964:Thyroid Neoplasms; D015043:Zollinger-Ellison Syndrome
chemical_list: D002395:Catecholamines; D012701:Serotonin