Activation by peptidases and cytotoxicity of 2-(L-alpha-aminoacyl) prodrugs of methotrexate.
Cheung
H T
HT
Department of Pharmacy, University of Sydney, NSW, Australia.
Dong
Z
Z
Escoffier
L
L
Smal
M A
MA
Tattersall
M H
MH
D000215:Acylation; D000596:Amino Acids; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D001407:Bacillus / Q000201:enzymology; D018826:CD13 Antigens; D002470:Cell Survival / Q000187:drug effects; D010450:Endopeptidases / Q000378:metabolism*; D005493:Folic Acid Antagonists; D007668:Kidney / Q000201:enzymology; D007780:Lacticaseibacillus casei / Q000201:enzymology; D007939:Leukemia L1210; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D011355:Prodrugs / Q000378:metabolism* / Q000633:toxicity*; D011751:Pyroglutamyl-Peptidase I / Q000378:metabolism; D013329:Structure-Activity Relationship; D013552:Swine; D014407:Tumor Cells, Cultured
D000596:Amino Acids; D005493:Folic Acid Antagonists; D011355:Prodrugs; D010450:Endopeptidases; D000626:Aminopeptidases; D018826:CD13 Antigens; D011751:Pyroglutamyl-Peptidase I; D008727:Methotrexate