[Effects of endotoxin on coronary circulation].
To investigate the effects of endotoxin (ETX) on coronary circulation, we infused endotoxin (4ng/ml) intravenously in a small dose (0.3ng/kg.min-1) which did not reduce the blood pressure, nor did it disturb the coronary autoregulation, and the flow kept constant during the ETX infusion. But when the left coronary artery descending branch (LAD) was narrowed and the LAD pressure was reduced to 4.67kPa, the ETX showed a vasodilator effect on the LAD (pre-ETX 65.2 +/- 29.2 ml/min, post-ETX 89.5 +/- 32.7 ml/min, P < 0.05). This effect suggested that the ETX in a small dose had a vasodilator effect on a narrowed coronary artery, even when it did not disturb the hemodynamics. The possible mechanisms were surveyed preliminarily.
Shen
X
X
Wang
S
S
Li
X
X
Huang
N
N
He
X
X
Yang
Z
Z
D000818:Animals; D001794:Blood Pressure; D003326:Coronary Circulation / Q000187:drug effects*; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology; D013552:Swine; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D004731:Endotoxins; D014665:Vasodilator Agents