title: Influence of morphine on the activity of low-threshold visceral mechanoreceptors in cats with acute pericarditis.
abstract: The purpose of this investigation was to test whether morphine (morphinum hydrochloricum) applied to the receptive field of the thoracic visceral afferent fibres modifies their activity. Experiments were performed on chloralose-anaesthetised cats, paralysed and artificially ventilated, in a state of pericarditis that was induced by intrapericardial injection of lambda-carrageenan and kaolin. Resulting acute inflammation was proven histopathologically and documented electrocardiographically. Single afferent fibres with receptive fields in thoracic viscera were dissected from thoracic sympathetic chain (19 fibres), as well as the vagus nerve (9 fibres). All tested fibres transmitted sensory information from the low-threshold mechanoreceptors. As a final result, it was found that morphine (0.001-1.0 mg/ml) when applied locally activates, depending on the dose, afferent fibres as follows: 12 sympathetic afferents (out of 12 tested), and 7 vagal afferents (out of 9 tested). In examining the specificity of morphine action, the preliminary local application of naloxone (1.0 mg/ml) just before morphine, blocked all excitatory responses. The excitatory response was present whether the receptive field was located in the inflammatory area, or outside it, in group III or IV fibres.
authors.affiliation: Warsaw Medical School, Department of Physiology, Faculty of Medicine, Krakowskie Przedmieście 26/28, Warsaw 00-325 Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bałkowiec
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kukuła
authors.forename: Paweł
authors.initials: P
authors.lastname: Szulczyk
mesh_terms: D000208:Acute Disease; D000818:Animals; D002351:Carrageenan; D002415:Cats; D004558:Electric Stimulation; D004562:Electrocardiography / Q000187:drug effects; D007616:Kaolin; D008465:Mechanoreceptors / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009475:Neurons, Afferent / Q000187:drug effects; D010493:Pericarditis / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D014630:Vagus Nerve / Q000166:cytology / Q000187:drug effects / Q000502:physiology
chemical_list: D007616:Kaolin; D009270:Naloxone; D009020:Morphine; D002351:Carrageenan