title: Sixteen years of cardiac transplantation: the Columbia Presbyterian Medical Center experience 1977 to 1993.
abstract: Cardiac transplantation is currently recognized as the best therapy available for the treatment of endstage heart disease. Since 1977, more than 650 cardiac transplants have been performed at CPMC, with a one-year survival rate currently approaching 85% and a 5-year survival rate approaching 65%. Throughout the 16-year experience with cardiac transplantation at CPMC, the criteria of eligibility for both donor and recipient candidates have been expanded to include older patients. In addition, pediatric patients requiring complex arterial or venous reconstruction and patients with elevated, but reversible pulmonary vascular resistance have been transplanted with excellent results. With the evolution of prolonged posttransplant survival has come a new group of complications associated with chronic long-term immunosuppressive therapy. These, and issues relating to cardiac retransplantation, continue to increase, largely because of the critical lack of organ donors. Continued efforts are being developed to optimize and reduce the total amount of immunosuppression administered postoperatively. Currently, research interests at CPMC include therapy for transplant coronary artery disease, left ventricular assist devices, and xenotransplantation. Ongoing investigations in these and other areas of transplantation have been established to encourage continued growth both within the field and at CPMC through the 21st century.
authors.affiliation: Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York.
authors.forename: R E
authors.initials: RE
authors.lastname: Michler
authors.forename: J M
authors.initials: JM
authors.lastname: Chen
authors.forename: D M
authors.initials: DM
authors.lastname: Mancini
authors.forename: K
authors.initials: K
authors.lastname: Reemtsma
authors.forename: E A
authors.initials: EA
authors.lastname: Rose
mesh_terms: D000046:Academic Medical Centers; D000206:Actuarial Analysis; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006084:Graft Rejection / Q000628:therapy; D006085:Graft Survival; D016027:Heart Transplantation / Q000401:mortality / Q000706:statistics & numerical data* / Q000639:trends; D006801:Humans; D007165:Immunosuppression Therapy; D007239:Infections / Q000188:drug therapy; D008297:Male; D009519:New York City / Q000453:epidemiology; D012086:Reoperation; D015996:Survival Rate; D014019:Tissue Donors
chemical_list: D000900:Anti-Bacterial Agents