Immunological findings of serological tests in steroid-responsive sensorineural hearing loss.
The following results were obtained after serological examination of 11 patients with steroid-responsive SNHL including a case with the aortitis syndrome (Takayasu disease) and sensorineural hearing loss, and 3 cases with positive syphilitic reaction. i) Abnormalities of serum immunoglobulins IgG or IgM level were found in 6 of 11 cases (54.5%), ii) Abnormalities in lymphocyte subsets were found in 7 of 14 cases (50.0%), iii) Immunologic abnormalities were thought to be present in patients with steroid-responsive SNHL and related diseases, but no findings specific to either group were observed.
Kanzaki
J
J
Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan.
Inoue
Y
Y
O-Uchi
T
T
D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D002648:Child; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D007958:Leukocyte Count; D016131:Lymphocyte Subsets / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D013587:Syphilis / Q000150:complications; D013601:T-Lymphocytes / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology; D013625:Takayasu Arteritis / Q000150:complications
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D003165:Complement System Proteins; D011241:Prednisone