Involvement of dopaminergic receptors in quinolinate-induced striatal lesions.
The purpose of this study was to examine the effects of blockade (sulpiride) and activation (quinpirole) of dopaminergic D2 (DA2) receptors on brain lesions subsequent to excessive activation of glutamate (GLU) receptors. Striatal lesions were produced by direct injection of quinolinic acid, an endogenous GLU receptor agonist. Sulpiride (100 mg kg-1 i.p., 30 min before quinolinic acid injection and 1 h after) significantly (p < or = 0.05) reduced the volume of the lesion by around 20%. Quinpirole (1.25 mg kg-1 i.p., 30 min before quinolinic acid injection) had no effect. The protective action of DA2 receptor blockade strongly suggests that quinolinic acid-induced excitotoxicity may be partly modulated by DA2 receptors.
Wahl
F
F
Department of Neurological Surgery, Institute of Neurology, Queen Square, London, UK.
Plotkine
M
M
Boulu
R
R
Obrenovitch
T
T
Symon
L
L
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D015259:Dopamine Agents / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004873:Ergolines / Q000494:pharmacology*; D008297:Male; D009336:Necrosis; D009410:Nerve Degeneration / Q000187:drug effects; D017378:Quinolinic Acid / Q000633:toxicity*; D019257:Quinpirole; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D017470:Receptors, Glutamate / Q000187:drug effects* / Q000502:physiology; D013469:Sulpiride / Q000494:pharmacology*
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D004873:Ergolines; D011954:Receptors, Dopamine; D017470:Receptors, Glutamate; D019257:Quinpirole; D013469:Sulpiride; D017378:Quinolinic Acid