[Inotropic effect of novel domestic cardiotonic agent, vesnarinone--test in vitro].
This paper reports the studies on the positive inotropic effect of the novel domestic cardiotonic agent, vesnarinone on isolated papillary muscle and atrium of guinea pigs and rabbits, and on the comparison of the positive inotropic effect and toxicity of vesnarinone with amrinone, milrinone and strophanthin. The result suggests that vesnarinone has an apparent dose-effect relationship on a positive inotropic effect, the strength of which is between amrinone and milrinone. The positive inotropic effect of vesnarinone is higher and the toxicity is lower than that of strophanthin.
Han
W
W
Drug Control Institute of Sichuan Province.
Qin
Y
Y
Zhang
Z
Z
Zhou
S
S
Yang
Z
Z
D000676:Amrinone / Q000494:pharmacology; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D020105:Milrinone; D009200:Myocardial Contraction / Q000187:drug effects*; D011719:Pyrazines; D011728:Pyridones / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D011817:Rabbits; D013268:Stimulation, Chemical
D002316:Cardiotonic Agents; D011719:Pyrazines; D011728:Pyridones; D011804:Quinolines; C041667:vesnarinone; D020105:Milrinone; D000676:Amrinone