title: Genetic factors controlling the expression of the abdominal-A gene of Drosophila within its domain.
abstract: The homeotic gene abdominal-A (abd-A) is normally expressed in parasegments 7 to 13. We find that the initial distribution of the product is approximately uniform within this domain, but the subsequent elaboration of the expression pattern results in differences between, as well as within, parasegments. We have investigated the possible role of several pair-rule, e.g. fushi tarazu, even-skipped, runt, hairy, paired, and segment polarity e.g. engrailed, wingless, naked, patched and cubitus interruptus genes on the patterning of abd-A expression. We find that the establishment of the original abd-A expression domain is independent of any of these genes, but most of them are required for the subsequent elaboration of abd-A expression within the domain. The genes fushi tarazu, and especially engrailed, appear to act as transcriptional activating factors of abd-A.
authors.affiliation: Centro de Biologia Molecular, Universidad Autónoma de Madrid-CSIC, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Macías
authors.forename: S
authors.initials: S
authors.lastname: Pelaz
authors.forename: G
authors.initials: G
authors.lastname: Morata
mesh_terms: D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D009154:Mutation; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D014157:Transcription Factors