title: Identification of a new DNA polymorphism tightly linked to DQ-alpha locus.
abstract: Utilizing Alu-polymerase chain reaction and single-strand conformation polymorphism technologies a new DNA restriction fragment length polymorphism was detected on a cosmid clone located on chromosome 6p21. An accurate analysis of allele frequency was carried out on a large series of unrelated individuals. Furthermore a detailed linkage analysis in several large pedigrees showed this new polymorphism to be tightly linked to the HLA-DQ alpha locus.
authors.affiliation: Servizio di Genetica Medica, IRCCS, Ospedale CSS, San Giovanni Rotondo, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Gasparini
authors.forename: A
authors.initials: A
authors.lastname: Bonizzato
authors.forename: A
authors.initials: A
authors.lastname: Totaro
authors.forename: L
authors.initials: L
authors.lastname: Zelante
mesh_terms: D001483:Base Sequence; D002896:Chromosomes, Human, Pair 6; D008040:Genetic Linkage; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010375:Pedigree; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D006683:HLA-DQ Antigens