[The effect of lipoic acid on the components of the glutathione system in the lacrimal fluid of patients with open-angle glaucoma].
Nonprotein SH groups and gamma-glutamyl transpeptidase were detected in the lacrimal fluid of patients with open-angle glaucoma and senile cataract and in controls (in 82 and 100% of the examinees, respectively). In stage II glaucoma SH group level was found reduced vs. that in stage I or control. Intake of lipoic acid by patients with stage II glaucoma resulted in a reliable increase of lacrimal SH group level. Measurements of lacrimal fluid nonprotein SH groups may be used to monitor antioxidant therapy of patients with open-angle glaucoma.
Filina
A A
AA
Davydova
N G
NG
Kolomoĭtseva
E M
EM
D000328:Adult; D000368:Aged; D002386:Cataract / Q000188:drug therapy / Q000378:metabolism; D004341:Drug Evaluation; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000378:metabolism; D005978:Glutathione / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013438:Sulfhydryl Compounds / Q000032:analysis; D013666:Tears / Q000737:chemistry / Q000187:drug effects*; D008063:Thioctic Acid / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000032:analysis / Q000187:drug effects
D013438:Sulfhydryl Compounds; D008063:Thioctic Acid; D005723:gamma-Glutamyltransferase; D005978:Glutathione
Vliianie lipoevoĭ kisloty na komponenty sistemy glutationa v sleznoĭ zhidkosti bol'nykh otkrytougol'noĭ glaukomoĭ.