title: Borna disease virus-specific T cells protect against or cause immunopathological Borna disease.
abstract: In this report we show that passive immunization of Lewis rats with viable CD4+, Borna disease virus (BDV)-specific T cells before infection with BDV resulted in protection against BD, whereas inoculation of these T cells after BDV infection induced clinical disease with more rapid onset than seen in BDV control animals. The protective as well as encephalitogenic effector functions of BDV-specific CD4+ T cells were mediated only by viable BDV-specific T cells. The protective situation was obtained by passive transfer of BDV-specific T cells into animals inoculated later with virus, whereas the immunopathological situation was observed when virus-specific T cells developed normally or after adoptive transfer, and appeared on the scene after considerable virus replication in the brain.
authors.affiliation: Institut für Virologie, Giessen, Germany.
authors.forename: J A
authors.initials: JA
authors.lastname: Richt
authors.forename: A
authors.initials: A
authors.lastname: Schmeel
authors.forename: K
authors.initials: K
authors.lastname: Frese
authors.forename: K M
authors.initials: KM
authors.lastname: Carbone
authors.forename: O
authors.initials: O
authors.lastname: Narayan
authors.forename: R
authors.initials: R
authors.lastname: Rott
mesh_terms: D000818:Animals; D001890:Borna Disease / Q000276:immunology* / Q000517:prevention & control; D001891:Borna disease virus / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D016219:Immunotherapy, Adoptive; D051381:Rats; D011917:Rats, Inbred Lew