title: [The pharmacological properties of karazedin].
abstract: The original agent 1,2,3,4,5,5a,6,10b-octahydroazepino-[4,5-b]indole (carazedine), an analog of the highly active antipsychotic drug carbidine, was synthesized. This agent was found to have various psychotropic activities and to be superior to carbidine, as shown by a number of tests, and combine properties typical of neuroleptics and tranquilizers. The toxicity of carazedine and carbidine was equal.
authors.forename: N K
authors.initials: NK
authors.lastname: Barkov
authors.forename: N M
authors.initials: NM
authors.lastname: Serpilina
authors.forename: L A
authors.initials: LA
authors.lastname: Surkova
authors.forename: L M
authors.initials: LM
authors.lastname: Sharkova
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Rusakov
authors.forename: I V
authors.initials: IV
authors.lastname: Tiurina
mesh_terms: D000661:Amphetamine / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000633:toxicity; D002243:Carbolines / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D002746:Chlorpromazine / Q000494:pharmacology / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D000882:Haplorhini; D007928:Lethal Dose 50; D051379:Mice; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D012110:Reserpine / Q000494:pharmacology / Q000633:toxicity
chemical_list: D014150:Antipsychotic Agents; D002243:Carbolines; D011619:Psychotropic Drugs; C087721:carazedine; D012110:Reserpine; D000661:Amphetamine; D002746:Chlorpromazine; C100106:dicarbine
vernacular_title: O farmakologicheskikh svoĭstvakh karazedina.