title: Encoded reaction cassette for the highly sensitive detection of the making and breaking of chemical bonds.
abstract: A reaction cassette has been designed for the highly sensitive detection of the making and breaking of chemical bonds. The system is envisioned as a companion device to be used in the search for antibody and other novel catalysts. The cassette also may have important clinical applications in the design of diagnostic reagents. In its fully encoded format, this methodology is capable of both detecting and decoding chemical events.
authors.affiliation: Scripps Research Institute, Department of Molecular Biology, La Jolla, CA 92037.
authors.forename: H
authors.initials: H
authors.lastname: Fenniri
authors.forename: K D
authors.initials: KD
authors.lastname: Janda
authors.forename: R A
authors.initials: RA
authors.lastname: Lerner
mesh_terms: D000906:Antibodies / Q000378:metabolism; D001483:Base Sequence; D002384:Catalysis; D002621:Chemistry / Q000379:methods*; D004247:DNA / Q000138:chemical synthesis*; D017931:DNA Primers / Q000138:chemical synthesis*; D010450:Endopeptidases / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D010455:Peptides / Q000737:chemistry*; D016133:Polymerase Chain Reaction / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D000906:Antibodies; D017931:DNA Primers; D009838:Oligodeoxyribonucleotides; D010455:Peptides; D004247:DNA; D010450:Endopeptidases