title: [Opioid analgesics in the treatment of non-malignant chronic pain].
abstract: Opioid sensitivity, residual pain, development of tolerance, physical and psychological dependence are described and discussed in relation to long-term opioid therapy. Based on this, guidelines for long-term opioid administration are established for chronic pain conditions of non-cancer origin. The indication must be well-considered--a life-long treatment may be instituted. Prior to final initiation of the treatment, a testing of the selected drug and method of administration should be performed. Due to the compliance-reasons, only long acting opioids should be used (controlled release morphine preparations, methadone, buprenorphine) and the route of administration should always be oral. The treatment must be individualised, covering 24 hours a day. The single dosages should be identical and administered with identical time intervals, which are determined by the duration of action of the drug in use. P.r.n.-administration should not be allowed. Only one physician should be responsible for the treatment and for the prescription of the opioid analgesic drugs.
authors.affiliation: Multidisciplinaert smertecenter, afdeling R., Bispebjerg Hospital, København.
authors.forename: J
authors.initials: J
authors.lastname: Eriksen
authors.forename: T G
authors.initials: TG
authors.lastname: Clausen
authors.forename: F M
authors.initials: FM
authors.lastname: Borgbjerg
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D004361:Drug Tolerance; D006801:Humans; D009294:Narcotics / Q000009:adverse effects / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000209:etiology / Q000523:psychology; D010148:Intractable Pain / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000523:psychology
chemical_list: D000701:Analgesics, Opioid; D009294:Narcotics
vernacular_title: Opioide analgetika i behandlingen af kroniske smerter af ikkecanceroprindelse.