title: Raised plasma endothelin-1 concentration in patients with nephropathia epidemica.
abstract: Nephropathia epidemica (NE) with renal syndrome, caused by the Puumala-virus, is manifested clinically by the triad of fever, hemorrhage and renal failure. We observed raised plasma concentrations of endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) in 23 patients during the acute phase of NE. They all developed transient renal failure and all displayed characteristics of NE, also verified by a rapid IgG antibody test. Blood pressure was normal or low in all subjects during the acute phase of the disease. Plasma ET-1 and ANP levels returned to normal following recovery one month later. The cause of increased ET-1 synthesis in NE remains unknown. It may be related to vascular damage or extravasation of blood. ET-1 may participate in the pathogenesis of acute renal failure of NE. Raised plasma ANP levels were most likely caused by fluid retention during the acute phase of NE. However, high levels of circulating ET-1 might have contributed to increased release of ANP.
authors.affiliation: Department of Medicine, Jyväskylä Central Hospital, Jyväskylä, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Forslund
authors.forename: R
authors.initials: R
authors.lastname: Liisanantti
authors.forename: O
authors.initials: O
authors.lastname: Saijonmaa
authors.forename: F
authors.initials: F
authors.lastname: Fyhrquist
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000097:blood; D016232:Endothelins / Q000097:blood*; D005260:Female; D006476:Orthohantavirus; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D016232:Endothelins; D009320:Atrial Natriuretic Factor