Influence of dietary sorbose on diabetes in nonobese diabetic mice.
The effect of dietary sorbose on diabetes after the incidence of the syndrome in the nonobese diabetic mouse was investigated in the animals from 8 to 14 weeks of age. When sucrose (200 g/kg diet) in a control diet was replaced by sorbose, the body weight and the blood glucose concentration were significantly reduced, but the serum insulin concentration was unchanged. The urinary glucose concentration was the same for both sucrose and sorbose diets. It is suggested that after the incidence of diabetes, dietary sorbose could not improve urinary excretion of glucose, even though sorbose could reduce the blood glucose concentration.
Furuse
M
M
Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
Kimura
C
C
Takahashi
H
H
Okumura
J
J
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006029:Glycosuria / Q000178:diet therapy; D007328:Insulin / Q000097:blood; D051379:Mice; D016688:Mice, Inbred NOD / Q000502:physiology*; D009929:Organ Size / Q000187:drug effects; D013013:Sorbose / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D013013:Sorbose