HIV-specific CD8+ T-cell immune responses and viral replication.
OBJECTIVE
To review current knowledge of CD8+ T cells in relation to their effect on the replication of HIV and on disease progression.
Both CD8+ cytotoxic T lymphocytes capable of killing cells expressing HIV antigens and CD8+ lymphocytes that suppress HIV replication in vitro are detectable in response to HIV infection.


CONCLUSIONS
These CD8+ T cells may help to maintain a low viral load in vivo, thus allowing a long asymptomatic period of infection.
Buseyne
F
F
Unit for Virology and Cellular Immunology, URA CNRS 1157, Pasteur Institute, Paris, France.
Rivière
Y
Y
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology; D016827:CD8 Antigens / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic; D006678:HIV / Q000276:immunology* / Q000502:physiology; D015658:HIV Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D008222:Lymphokines / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014779:Virus Replication / Q000276:immunology
D016827:CD8 Antigens; D008222:Lymphokines