[The behavior of sperm antibody titers after immunization of guinea pigs with their own sperm and after experimental unilateral cryptorchism].
Four guinea pigs were immunized against sperms from their own epididymis. The titers of autoantibodies against the sperms in the tubuli of the parenchyma testis increased after 4 weeks. The heads of sperms were also gummed up. The left testis of another 7 guinea pigs were shifted into the abdominal cavity. These animals showed also increasing autoantibody-titer. The observations demonstrated, that the blood-testis-barrier is a physiological one for the autoantibodies. At higher temperatures, as with cryptorchid testes, this barrier becomes permeable for antibodies so that infertility can result.
Draehmpaehl
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Institut für Anatomie, Veterinärmedizinische Fakultät, Freien Universität Berlin.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D003456:Cryptorchidism / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization; D007248:Infertility, Male / Q000276:immunology*; D008297:Male; D013094:Spermatozoa / Q000276:immunology*
D001323:Autoantibodies
Das Verhalten des Spermien-Autoantikörper-Titers nach Immunisierung mit eigenem Sperma und nach künstlich erzeugtem einseitigen Kryptorchismus bei Meerschweinchen.