title: Anxiolytic activity of tachykinin NK2 receptor antagonists in the mouse light-dark box.
abstract: The tachykinin NK2 receptor antagonists, GR100679 (0.02-200 micrograms/kg s.c.) and (+/-)-SR489698 (0.05-5.0 micrograms/kg s.c.), dose-dependently increased the time which mice spent in the light side of the light-dark box. There was no evidence of sedation or other over behaviours. The amplitudes of these effects were similar to that evoked by diazepam (1.75 mg/kg s.c.). These results indicate a disinhibitory action of NK2 antagonists on suppressed behaviours in a novel aversive environment. This suggests an involvement of NK2 receptors in anxiety-related behaviours.
authors.affiliation: Neuropharmacology Department, Glaxo Group Research, Ware, Hertfordshire, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Stratton
authors.forename: I J
authors.initials: IJ
authors.lastname: Beresford
authors.forename: F J
authors.initials: FJ
authors.lastname: Harvey
authors.forename: M P
authors.initials: MP
authors.lastname: Turpin
authors.forename: R M
authors.initials: RM
authors.lastname: Hagan
authors.forename: M B
authors.initials: MB
authors.lastname: Tyers
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000209:etiology; D001522:Behavior, Animal / Q000187:drug effects*; D001549:Benzamides / Q000008:administration & dosage / Q000494:pharmacology*; D003624:Darkness; D007279:Injections, Subcutaneous; D008027:Light; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors*
chemical_list: D014151:Anti-Anxiety Agents; D001549:Benzamides; D009842:Oligopeptides; D010880:Piperidines; D018041:Receptors, Neurokinin-2; C083380:GR 100679; C073839:SR 48968