Protective effect of ternatin, a flavonoid isolated from Egletes viscosa less., in experimental liver injury.
The effect of ternatin, a tetramethoxyflavone from Egletes viscosa Less., on liver injury induced by carbon tetrachloride (CCl4) was investigated in rats. Twenty-four hours following CCl4 insult (2.5 ml/kg s.c.), changes in the serum enzymes, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase, as well as liver cell histology were used as indices of hepatic dysfunction. The results show that ternatin (30 mg/kg i.p. daily for 5 consecutive days) causes marked inhibition of CCl4-induced serum enzymes and morbid histologic changes. The observation suggests that ternatin possesses antihepatotoxic activity.
Rao
V S
VS
Department of Physiology, Federal University of Ceará, Fortaleza, Brazil.
Figueiredo
E G
EG
Melo
C L
CL
Viana
G S
GS
Menezes
D B
DB
Matos
M S
MS
Silveira
E R
ER
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D005419:Flavonoids; D010936:Plant Extracts; C051080:ternatin (flavonoid); D002251:Carbon Tetrachloride; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase