Increased plasma M-CSF concentration in patients with adult T cell leukemia: clinical correlation.
Plasma concentration of M-CSF was measured in 35 patients with adult T cell leukemia (ATL), using a radioimmunoassay (RIA). ATL patients showed elevated levels of plasma M-CSF concentration when compared with healthy adult volunteers. Higher M-CSF levels were observed in acute ATL patients than in patients with chronic or smouldering ATL (P < 0.0001). There was a significant positive correlation of M-CSF concentration with serum lactic dehydrogenase (LDL) level, a reliable marker for assessing the grade of malignancy in ATL (P = 0.0003). There was, however, no correlation of M-CSF concentration with total counts of peripheral blood ATL cells, neutrophils or monocytes, or with serum calcium levels. Although there was a significant positive correlation of M-CSF concentration with body temperature (P = 0.003), there was not a significant correlation of M-CSF concentration with C-reactive protein (CRP), a protein indicative of the severity of inflammation (P = 0.063). These results indicate that plasma M-CSF concentration reflects the disease activity of ATL, and can thus serve as a marker in the clinical subclassification of ATL patients.
Yamada
Y
Y
Department of Hematology, Nagasaki University School of Medicine, Japan.
Ohmoto
Y
Y
Murata
K
K
Tsukasaki
K
K
Momita
S
S
Kamihira
S
S
Atogami
S
S
Sohda
H
H
Moriuchi
Y
Y
Itoyama
T
T
D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood* / Q000145:classification; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D009363:Neoplasm Proteins / Q000097:blood; D011289:Preleukemia / Q000097:blood
D014408:Biomarkers, Tumor; D016207:Cytokines; D009363:Neoplasm Proteins; D016173:Macrophage Colony-Stimulating Factor; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase