Intrastriatal infusion of amiloride increases rotations in 6-OHDA lesioned rats and "down-regulates" D2 receptors in the striatum and 5-HT2A receptors in the cortex.
Intrastriatal infusion of amiloride and 12-0-tetradeconoyl phorbol-13-acetate (TPA) in 6-OHDA lesioned rats increased the apomorphine (APO)-induced rotation. This behavioral effect occurred in the presence of a decrease in the density and an increase in the affinity of D2 dopamine receptors in the striatum. There was an associated decrease in the number of 5-HT2A receptors labelled with ketanserin in the cortex on the side of infusion. These results suggest that the inositol second-messenger system may be involved in the regulation of D2-dopamine receptors in the striatum and dopamine mediated behavior in the 6-OHDA lesioned rats. They also indicate a possible role for the inositol second messenger system in the regulation of 5-HT2A receptors.
Jamrozik
Z
Z
Department of Neurology, Medical Academy, Warszawa, Poland.
De Yebenes
J G
JG
Troung
D D
DD
Cadet
J
J
D000584:Amiloride / Q000008:administration & dosage / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001667:Binding, Competitive; D002540:Cerebral Cortex / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D015536:Down-Regulation; D015918:Infusion Pumps, Implantable; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D016627:Oxidopamine / Q000633:toxicity; D011112:Polymyxin B / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage / Q000494:pharmacology
D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D000584:Amiloride; D016627:Oxidopamine; D011112:Polymyxin B; D001058:Apomorphine; D013755:Tetradecanoylphorbol Acetate