Anticholinesterases and experimental envenomation by Naja.
Danger from snake bites, especially those of Elapidae, pose a public health problem in a large number of tropical and sub-tropical countries. Since the advent of serotherapy, the morality rate has decreased, but suitable sera are not always available, explaining the usefulness of developing symptomatic treatments. The present study is a test of the preventative and curative efficacy of anticholinesterases in the treatment of Naja haje haje venom envenomation. It is clearly shown that the early use of these products leads to a considerable increase in the LD50 in mice having undergone experimental envenomation.
Guieu
R
R
Laboratoire de Biochimie, Faculté de Médecine secteur Nord, Marseille, France.
Rosso
J P
JP
Rochat
H
H
D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives / Q000627:therapeutic use; D001285:Atropine / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004546:Elapid Venoms / Q000633:toxicity*; D017815:Elapidae; D005260:Female; D007928:Lethal Dose 50; D008239:Lysine / Q000031:analogs & derivatives / Q000627:therapeutic use; D051379:Mice; D009388:Neostigmine / Q000627:therapeutic use; D011729:Pyridostigmine Bromide / Q000627:therapeutic use; D012909:Snake Bites / Q000188:drug therapy*; D014700:Verapamil / Q000627:therapeutic use
D002800:Cholinesterase Inhibitors; D004546:Elapid Venoms; D009388:Neostigmine; D001285:Atropine; D014700:Verapamil; D008239:Lysine; D011729:Pyridostigmine Bromide; D001241:Aspirin; C010395:acetylsalicylic acid lysinate