[A model for the study of CNS excitability (the potentials for research on the antiepileptic activity of preparations in a chronic experiment)].
The proposed model is required to study the level of CNS excitability in chronic experiment. Series of subcutaneous subconvulsant doses of corazole, 10 mg/kg, are repeated throughout the whole experiment. Each series of injections is given until generalized convulsions develop, thereafter the mean convulsant dose the convulsant is calculated in the given experiment session. This dose indirectly reflects the level of CNS excitability. The simultaneous administration of anticonvulsants enables evaluation of their efficiency for unlimited periods.
Kozlovskiĭ
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D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001224:Aspartic Acid / Q000008:administration & dosage; D002490:Central Nervous System / Q000187:drug effects*; D002908:Chronic Disease; D004032:Diet; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004829:Epilepsy, Generalized / Q000139:chemically induced* / Q000188:drug therapy; D005971:Glutamates / Q000008:administration & dosage; D018698:Glutamic Acid; D008297:Male; D010433:Pentylenetetrazole / Q000008:administration & dosage; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013997:Time Factors
D000927:Anticonvulsants; D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D010433:Pentylenetetrazole
Model' izucheniia vozbudimosti TsNS (vozmozhnosti issledovaniia protivoépilepticheskoĭ aktivnosti preparatov v usloviiakh khronicheskogo opyta.