Beneficial effects of beta-adrenergic blockade in coronary artery surgery: clinical research.
In an attempt to resolve the controversy concerning use of beta-adrenoceptor blockade in patients undergoing coronary artery revascularization, 40 consecutive patients with ischaemic heart disease receiving chronic beta-adrenergic blocking therapy (study group) were entered into a randomized trial and were compared with 40 patients receiving no beta-blocking therapy (control group). The postoperative requirement for positive inotropic agents between the two groups was compared. The clinical and operative characteristics of the two groups were similar. After surgery, 2% of patients in the study group required positive inotropic agents compared with 18% of those in the control group (P < 0.05). It is concluded that this difference resulted from an increase in density of beta 1-adrenergic receptors induced by beta-adrenergic blockade, and an increase in the level of catecholamines in the early postoperative period.
Yorulmaz
F M
FM
Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
Kuralay
E
E
Tatar
H
H
Süer
H
H
Oztürk
O Y
OY
D000070:Acebutolol / Q000008:administration & dosage / Q000009:adverse effects; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology*; D011292:Premedication
D000319:Adrenergic beta-Antagonists; D002316:Cardiotonic Agents; D000070:Acebutolol; D008790:Metoprolol