title: The Wellcome Lecture, 1992. Cell cycle control.
abstract: Genetic analysis using the fission yeast has provided a powerful methodology to investigate the eukaryotic cell cycle and its control. The onset of M-phase in fission yeast is controlled by a regulatory gene network which activates the p34cdc2 protein kinase encoded by the cdc2+ gene. The coupling of M-phase to the completion of S-phase also works through p34cdc2. A similar network is operative in vertebrate cells. Future work will focus on the controls regulating onset of S-phase and on the mechanisms by which a cell duplicates itself in space during division.
authors.affiliation: Department of Biochemistry, University of Oxford, U.K.
authors.forename: P
authors.initials: P
authors.lastname: Nurse
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D016203:CDC2 Protein Kinase / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics* / Q000502:physiology; D004261:DNA Replication; D004271:DNA, Fungal / Q000096:biosynthesis / Q000235:genetics; D005800:Genes, Fungal; D006801:Humans; D008938:Mitosis / Q000235:genetics; D016196:S Phase / Q000235:genetics; D012568:Schizosaccharomyces / Q000166:cytology* / Q000235:genetics* / Q000378:metabolism; D006113:United Kingdom; D014714:Vertebrates
chemical_list: D004271:DNA, Fungal; D016203:CDC2 Protein Kinase