title: Concentric left ventricular hypertrophy in patients with Takayasu arteritis.
abstract: Although aortic regurgitation (AR) in patients with Takayasu arteritis (TA) is believed to be caused by dilatation of the aortic ring or thickening of the aortic cusps, the pattern of left ventricular hypertrophy (LVH) in these patients has not been described. To clarify the geometry of the LV in patients with TA that had been documented both echocardiographically and hemodynamically, the authors evaluated 22 patients with TA and severe AR (group 1), 10 with TA and systemic hypertension (group 2), and 17 with isolated severe AR of other etiologies (group 3). M-mode echocardiography showed that LV dimensions were smaller in groups 1 and 2 than in group 3 and that wall thickness was greater in group 1 than in group 3. The concentric hypertrophic ratio (CHR = wall thickness/LV end-diastolic dimension+wall thickness) was larger than group 1 (p < 0.001) and group 2 (p < 0.01) than in group 3. CHR was similar in groups 1 and 2. Systolic blood pressure was significantly increased in group 2 and showed a tendency to increase in group 1 as compared with group 3. The results confirmed the presence of concentric LVH related to a pressure overload in patients with TA, even when TA was complicated by severe AR.
authors.affiliation: Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Oniki
authors.forename: E
authors.initials: E
authors.lastname: Kaneko
authors.forename: A
authors.initials: A
authors.lastname: Hata
authors.forename: A
authors.initials: A
authors.lastname: Matsumura
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: F
authors.initials: F
authors.lastname: Numano
mesh_terms: D000328:Adult; D001022:Aortic Valve Insufficiency / Q000209:etiology* / Q000503:physiopathology; D001794:Blood Pressure; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013625:Takayasu Arteritis / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D014463:Ultrasonography