Epstein-Barr virus-associated lymphoproliferative disorders in oral cavity after heart transplantation: report of a case.
Clinical manifestations of Epstein-Barr virus associated with post-heart transplant lymphoproliferative disorders (PTLD) are variable. Over one-half of the PTLD express extranodal presentations, of which gastrointestinal symptoms are the most common. Development of oral ulcers is an extremely rare initial manifestation with only three such cases having been reported. A case of oropharyngeal presentation of PTLD is described here. The clinical presentations and pathologic spectrums of PTLD are discussed. Posttransplant lymphoproliferative disorders are considered to be iatrogenic and life-threatening and are associated with immunosuppressive agents and Epstein-Barr virus infection. Early diagnosis and appropriate management could prevent the fatal progression of such disorders. The need to analyse tumor clonality along with observation of clinical presentations and microscopic pathology in order to diagnose PTLD is discussed.
Chang
H
H
Department of Pathology, Veterans General Hospital-Kaohsiung, Taiwan, R.O.C.
Wu
J D
JD
Cheng
K K
KK
Tseng
H H
HH
D000293:Adolescent; D016027:Heart Transplantation / Q000009:adverse effects*; D006566:Herpesviridae Infections / Q000209:etiology / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D008297:Male; D009059:Mouth Diseases / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D014412:Tumor Virus Infections / Q000209:etiology / Q000473:pathology*