title: Cytomegalovirus reactivation and tumour necrosis factor.
abstract: Tumour necrosis factor-alpha (TNF) stimulates cytomegalovirus (CMV) activity in a transfected human monocytic cell line. We assessed whether this finding is relevant in vivo by evaluating the frequency of active CMV infection in patients with diseases that enhance plasma TNF. In septic disease, peripheral blood mononuclear cells of almost all patients studied were positive for CMV. Furthermore, CMV antigenaemia and enhanced plasma TNF occurred in many patients with liver cirrhosis, common variable immunodeficiency, and B-cell chronic lymphocytic leukaemia. Thus, TNF may have a central role in CMV reactivation.
authors.affiliation: Institute of Medical Immunology, Medical School-Charité, Humboldt University, Berlin, Germany.
authors.forename: W D
authors.initials: WD
authors.lastname: Döcke
authors.forename: S
authors.initials: S
authors.lastname: Prösch
authors.forename: E
authors.initials: E
authors.lastname: Fietze
authors.forename: V
authors.initials: V
authors.lastname: Kimel
authors.forename: H
authors.initials: H
authors.lastname: Zuckermann
authors.forename: C
authors.initials: C
authors.lastname: Klug
authors.forename: U
authors.initials: U
authors.lastname: Syrbe
authors.forename: D H
authors.initials: DH
authors.lastname: Krüger
authors.forename: R
authors.initials: R
authors.lastname: von Baehr
authors.forename: H D
authors.initials: HD
authors.lastname: Volk
mesh_terms: D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000097:blood*; D016022:Case-Control Studies; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000150:complications; D003587:Cytomegalovirus / Q000254:growth & development / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000150:complications / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000097:blood; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications; D007963:Leukocytes, Mononuclear / Q000382:microbiology*; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012008:Recurrence; D018805:Sepsis / Q000097:blood* / Q000150:complications / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014775:Virus Activation
chemical_list: D000956:Antigens, Viral; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha