title: The usefulness and limitations of combined Tc-99m pertechnetate and Ga-67 citrate imaging of salivary gland disorders.
abstract: The usefulness of combined Tc-99m and Ga-67 scans in diagnosing salivary gland disorders was evaluated in a total of 31 patients. Out of 6 patients with Warthin's tumor, 4 showed a typical pattern of high-activity in the gland with retention of Tc-99m, but without an affinity for Ga-67. Out of 9 patients with pleomorphic adenoma, 8 showed a "cold" area in the tumor by Tc-99m and 5 of the 9 patients had accumulated Ga-67. Five of 6 patients with malignant tumor showed an affinity for Ga-67. Nine of 10 patients with sialadenitis showed diffuse uptake of both Tc-99m and Ga-67 in the involved gland. Combined Tc-99m and Ga-67 imaging was useful in detecting the cases of Warthin's tumor and sialadenitis (90% sensitivity and 89% specificity for sialadenitis), but the study had limitations in differentiating malignant tumors from benign tumors (66% sensitivity and 84% specificity). However, Ga-67 imaging showed a 91% negative predictive value. A negative scan could almost rule out the possibility of malignant disease of the salivary gland.
authors.affiliation: Department of Radiology, Yamanashi Medical University, Japan.
authors.forename: A S
authors.initials: AS
authors.lastname: Arbab
authors.forename: K
authors.initials: K
authors.lastname: Koizumi
authors.forename: G
authors.initials: G
authors.lastname: Uchiyama
authors.forename: T
authors.initials: T
authors.lastname: Arai
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D000235:Adenolymphoma / Q000000981:diagnostic imaging; D008949:Adenoma, Pleomorphic / Q000000981:diagnostic imaging; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002951:Citrates; D019343:Citric Acid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018198:Mixed Tumor, Malignant / Q000000981:diagnostic imaging; D010307:Parotid Neoplasms / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012466:Salivary Gland Diseases / Q000000981:diagnostic imaging*; D012793:Sialadenitis / Q000000981:diagnostic imaging; D013670:Sodium Pertechnetate Tc 99m; D013365:Submandibular Gland Neoplasms / Q000000981:diagnostic imaging
chemical_list: D002951:Citrates; D019343:Citric Acid; D013670:Sodium Pertechnetate Tc 99m