Effect of the sulfonylurea glyburide on glycogen synthesis in alloxan-induced diabetic rat hepatocytes.
1. The effect of glyburide (glibenclamide) treatment on the liver glycogen levels of diabetic rats have been studied. 2. 3 weeks treatment with glyburide (5 mg/kg, orally) increased liver glycogen and decreased blood glucose levels. 3. The results of this study demonstrated that the sulfonylurea, glyburide is capable of exerting direct insulin-like effects on liver glycogen values in vivo.
Atalay
T
T
Department of Biochemistry, Faculty of Medicine, University of Gazi, Besevler, Ankara, Turkey.
Altan
N
N
Ongun
C O
CO
Alagöl
H
H
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008112:Liver Glycogen / Q000096:biosynthesis*; D051381:Rats
D008112:Liver Glycogen; D005905:Glyburide