Chemokine-induced fever: intracerebroventricular actions of MIP-1 and MIP-1 alpha in rats.
The central pyrogenic actions in the rat of doublet macrophage inflammatory protein-1 (MIP-1) and MIP-1 alpha were determined by their intracerebroventricular infusion. Doses of 560 pg and 11.2 ng of MIP-1 or 10.0 ng MIP-1 alpha infused into the third cerebral ventricle induced a long lasting fever. However, MIP-1 alpha was much less potent than MIP-1 in terms of intensity and longer latency. Overall, these cytokines are pyrogenic when acting on the walls of the third ventricle; however, a dose 10 times greater than that injected directly into the anterior hypothalamus is required to evoke fever, as based on earlier experiments. Finally, circulating MIP-1 could act centrally by its entry through the choroid plexus into the ventricular system of the brain.
Zawada
W M
WM
Department of Clinical Pharmacology, University of Colorado Health Sciences Center, Denver 80262.
Ruwe
W D
WD
Clarke
J
J
Wall
P T
PT
Myers
R D
RD
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D054407:Chemokine CCL4; D016207:Cytokines / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced*; D007276:Injections, Intraventricular; D019402:Macrophage Inflammatory Proteins; D008297:Male; D015846:Monokines / Q000008:administration & dosage / Q000633:toxicity*; D011301:Preoptic Area / Q000503:physiopathology; D011749:Pyrogens / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D054407:Chemokine CCL4; D016207:Cytokines; D019402:Macrophage Inflammatory Proteins; D015846:Monokines; D011749:Pyrogens