title: [The pharmacokinetic characteristics of fenazepam in epileptics].
abstract: Testing the injectable dosage form of phenazepam showed no substantial pharmacokinetic differences in epileptic patients receiving a single intravenous and intramuscular doses of 2 mg. The bioavailability of the drug was 0.82. The individual and mean experimental stationary phenazepam concentration (157.3 ng/ml) in the patients' blood during course intramuscular therapy was found to be close to the theoretical stationary one (150.6 ng/ml). The pharmacokinetic findings allow one to optimize phenazepam therapy for epileptic patients.
authors.forename: E L
authors.initials: EL
authors.lastname: Maksutova
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: E V
authors.initials: EV
authors.lastname: Zheleznova
mesh_terms: D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D004827:Epilepsy / Q000097:blood*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
vernacular_title: Farmakokineticheskie kharakteristiki fenazepama u bol'nykh épilepsieĭ.