Mitochondrial DNA damage and efficiency of ATP biosynthesis: mathematical model.
The role of mitochondrial DNA (mtDNA) damage in ageing processes and in malignant transformation of a cell is discussed. A mathematical model of the mtDNA population in a cell and in tissue is constructed. The model describes the effects of mtDNA damages accumulated during ageing and some features of malignant transformation and regeneration.
Beregovskaya
N
N
Research Center for Biotechnological Systems SONAR, Ukrainian Academy of Sciences.
Maiboroda
R
R
D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence; D004249:DNA Damage; D004272:DNA, Mitochondrial; D008433:Mathematics; D008954:Models, Biological; D012038:Regeneration
D004272:DNA, Mitochondrial; D000255:Adenosine Triphosphate