title: Spontaneous retinal changes in Sprague Dawley rats.
abstract: Routine ophthalmological examination of over 6,000 untreated Crl:CD(SD)BR rats up to 2 years old, used in toxicologic studies from 1989 to 1992, has provided information on spontaneous retinal changes and their incidence with age. Focal linear retinopathy and coloboma were the most common findings; retinal hemorrhage, saccular aneurysm of the retinal vessels, retinal fold, absence of optic disk and retinal vascularization, and myelination of optic nerve fibers were also observed. Such accumulated data in untreated animals are of prime necessity in assessing possible drug- and chemical-induced effects on the eye after either systemic or local exposure.
authors.affiliation: Department of Safety Assessment, Centre de Recherche Merck Sharp & Dohme-Chibret, Riom, France.
authors.forename: M F
authors.initials: MF
authors.lastname: Hubert
authors.forename: J P
authors.initials: JP
authors.lastname: Gillet
authors.forename: G
authors.initials: G
authors.lastname: Durand-Cavagna
mesh_terms: D000375:Aging; D000783:Aneurysm / Q000662:veterinary; D000818:Animals; D005123:Eye / Q000196:embryology; D005124:Eye Abnormalities / Q000662:veterinary; D005260:Female; D008297:Male; D009413:Nerve Fibers, Myelinated; D009898:Optic Disk / Q000002:abnormalities; D051381:Rats; D017207:Rats, Sprague-Dawley; D012164:Retinal Diseases / Q000139:chemically induced / Q000662:veterinary*; D012166:Retinal Hemorrhage / Q000662:veterinary; D012171:Retinal Vessels