title: Single-breath nitric oxide measurements in asthmatic patients and smokers.
abstract: Exhaled nitric oxide (NO) concentrations were measured in asthmatic outpatients and in non-smoking and smoking healthy controls. In single exhalations, NO showed a peak suggestive of airway origin in both controls and asthmatic patients. The peak NO concentration was higher in asthmatic patients and lower in smokers than in non-smoking controls (p < 0.05). The findings support a role for NO in the host defence response in asthma and suggest that NO measurements can discriminate between different types of lung disorders.
authors.affiliation: Department of Physiology, Karolinska Institute, Stockholm, Sweden.
authors.forename: M G
authors.initials: MG
authors.lastname: Persson
authors.forename: O
authors.initials: O
authors.lastname: Zetterström
authors.forename: V
authors.initials: V
authors.lastname: Agrenius
authors.forename: E
authors.initials: E
authors.lastname: Ihre
authors.forename: L E
authors.initials: LE
authors.lastname: Gustafsson
mesh_terms: D000328:Adult; D001249:Asthma / Q000378:metabolism* / Q000503:physiopathology; D001944:Breath Tests; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000032:analysis*; D012119:Respiration / Q000502:physiology; D012907:Smoking / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D009569:Nitric Oxide