title: Novel bioactive compounds from actinomycetes.
abstract: Actinomycetes form an enormous reservoir of secondary metabolites and enzymes. The potential for exploiting rare actinomycetes is highlighted by the discovery of novel compounds from strains of Spirillospora and Nocardioides. Novel compounds of well known classes of antibiotics, such as polyenes, continue to be discovered. For compounds containing a chromophore, the analysis by high-performance liquid chromatography coupled with a diode-array detector enables the elimination of producers of known compounds and facilitates the discovery of novel compounds or derivatives. The complexity of the regulatory mechanisms is illustrated by glutamine synthetase. The characterization of thermostable amylolytic, lignolytic, peroxidase and neuramidase activities, and the isolation of novel cellulolytic actinomycetes clearly demonstrate the potential of Actinomycetes as producers of enzymes.
authors.affiliation: Sandoz Pharma Ltd., Basel, Switzerland.
authors.forename: J J
authors.initials: JJ
authors.lastname: Sanglier
authors.forename: E M
authors.initials: EM
authors.lastname: Wellington
authors.forename: V
authors.initials: V
authors.lastname: Behal
authors.forename: H P
authors.initials: HP
authors.lastname: Fiedler
authors.forename: R
authors.initials: R
authors.lastname: Ellouz Ghorbel
authors.forename: C
authors.initials: C
authors.lastname: Finance
authors.forename: M
authors.initials: M
authors.lastname: Hacene
authors.forename: A
authors.initials: A
authors.lastname: Kamoun
authors.forename: C
authors.initials: C
authors.lastname: Kelly
authors.forename: D K
authors.initials: DK
authors.lastname: Mercer
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis*; D000935:Antifungal Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004798:Enzymes / Q000378:metabolism; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D066298:In Vitro Techniques; D009439:Neuraminidase / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004798:Enzymes; D009439:Neuraminidase; D005974:Glutamate-Ammonia Ligase