title: [Antiphospholipid antibodies: cause of thrombosis or an epiphenomenon?].
abstract: Antiphospholipid antibodies (aPL) present in systemic lupus erythematosus and the primary antiphospholipid syndrome are a well-known risk factor for thrombosis. Most of them require the presence of a cofactor, beta 2-glycoprotein I for anticardiolipin antibodies, prothrombin for lupus anticoagulant. These aPL are of the "immune" type. APL are also found in various non-immunological conditions, in which repeated endothelial or membranous damages appear to be frequent, but thromboses are rare. Most of these aPL are cofactor-independent, except those induced by chlorpromazine, and might belong to "natural" antibodies.
authors.affiliation: Service de Médecine interne, CHU Pitié-Salpêtrière, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Karmochkine
authors.forename: J C
authors.initials: JC
authors.lastname: Piette
authors.forename: E
authors.initials: E
authors.lastname: Mazoyer
authors.forename: B
authors.initials: B
authors.lastname: Wechsler
authors.forename: P
authors.initials: P
authors.lastname: Chérin
authors.forename: S
authors.initials: S
authors.lastname: Herson
authors.forename: P
authors.initials: P
authors.lastname: Godeau
authors.forename: M C
authors.initials: MC
authors.lastname: Boffa
mesh_terms: D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D012307:Risk Factors; D013927:Thrombosis / Q000276:immunology* / Q000503:physiopathology
chemical_list: D017152:Antibodies, Antiphospholipid
vernacular_title: Anticorps antiphospholipides: cause des thromboses ou épiphénomène?