Evaluation of virulence factors and the adhesive capability of Escherichia coli strains.
Escherichia coli strains recently isolated from adult women with recurrent urinary tract infection (R-UTI) were compared with strains from women with non-recurrent infections (UTI). Haemolysin and mannose-resistant (MR) haemagglutinin were more prevalent in the first group. Using a spectrophotometric technique with biotinylated bacteria, the ability of bacteria to adhere to uroepithelial cells was related to this last character. R-UTI strains are also more resistant to the phagocytic activity of U937 cells. This could relate in vivo to a resistance to mucosal phagocytes, so as to prevent host defence mechanisms.
Savoia
D
D
Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Italy.
Millesimo
M
M
Fontana
G
G
D000328:Adult; D001422:Bacterial Adhesion; D004848:Epithelium / Q000382:microbiology / Q000473:pathology; D004926:Escherichia coli / Q000166:cytology / Q000378:metabolism / Q000472:pathogenicity*; D005260:Female; D006388:Hemagglutinins / Q000378:metabolism; D006460:Hemolysin Proteins / Q000378:metabolism; D006801:Humans; D010587:Phagocytosis; D012008:Recurrence; D013045:Species Specificity; D001743:Urinary Bladder / Q000382:microbiology / Q000473:pathology; D014552:Urinary Tract Infections / Q000276:immunology / Q000382:microbiology / Q000652:urine; D014774:Virulence
D006388:Hemagglutinins; D006460:Hemolysin Proteins