title: Synthesis of 2-methylaminobenzimidazole derivatives tested for antiinflammatory activity.
abstract: A series of 1-alkyl substituted 2-methylaminobenzimidazole derivatives was prepared and tested. Some of them were assayed orally in the rat for antiinflammatory and analgesic properties. The compounds did not exhibit any significant activity compared with reference drug levels.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Pisa, Pisa.
authors.forename: A
authors.initials: A
authors.lastname: Da Settimo
authors.forename: A M
authors.initials: AM
authors.lastname: Marini
authors.forename: A M
authors.initials: AM
authors.lastname: Bianucci
authors.forename: G
authors.initials: G
authors.lastname: Primofiore
authors.forename: F
authors.initials: F
authors.lastname: Da Settimo
authors.forename: E
authors.initials: E
authors.lastname: Boldrini
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012015:Reference Standards; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001562:Benzimidazoles