[Behavior of adult mice of various strains after exposure of thiophosphamide during organogenesis].
Females of strains 101/HY and CBA were treated with a single dose of thio-TEPA (0, 0.625, or 1.25 mg/kg body weight) on day 12 of gestation (deposition of a vaginal plug was considered as the first day of gestation). Special experiments were performed on their offspring at 3 months of age to study exploratory-research activity (burrow reactions, upright postures), locomotor activity in a "open field" cage, emotional reactivity, and level of feeding motivation. Changes in behavior after exposure to thio-TEPA were observed in mice of both sexes and genotypes; however, in 101/HY mice, which are characterized by genetically determined genome instability and a defect in DNA repair system, such changes were more pronounced. In general, they may be defined as a decrease in intensity of exploratory-research activity with some modulation of the level of motor activity. Sex differences in behavior of animals of both strains after prenatal exposure to thio-TEPA were also found. The data provide evidence about the specific role of genetic factors in variation of mouse behavior after prenatal exposure to thiophosphamide and allow consideration of thio-TEPA as a behavioral teratogen.
Lil'p
I G
IG
Bizikoeva
F Z
FZ
Poletaeva
I I
II
Ivanov
V I
VI
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004260:DNA Repair / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005838:Genotype; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013045:Species Specificity; D013723:Teratogens / Q000494:pharmacology*; D013852:Thiotepa / Q000494:pharmacology*
D013723:Teratogens; D013852:Thiotepa
Povedenie vzroslykh mysheĭ raznykh liniĭ posle vozdeĭstviia tiofosfamida vo vremia organogeneza.