Review article: the transjugular intrahepatic portosystemic shunt (TIPS) in the treatment of portal hypertension.
The transjugular intrahepatic portosystemic shunt (TIPS) is a non-surgical intrahepatic shunt connecting the hepatic and portal veins. The shunt can be inserted successfully in more than 90% of patients and it effectively decompresses the portal venous circulation. Serious complications, such as intraperitoneal bleeding, occur but they are uncommon. The role of TIPS in the treatment of portal hypertension is currently being evaluated. There are few controlled data available to compare TIPS with established treatment such as drugs, injection sclerotherapy, endoscopic banding or shunt surgery. TIPS has also been used to treat ascites, the Budd-Chiari syndrome and cirrhotic hydrothorax. Concerns over the long-term patency and the true incidence of encephalopathy following TIPS raise doubts about its long-term efficacy. Controlled trials are required to demonstrate the cost-effectiveness of TIPS for individual indications before it is widely adopted. TIPS may find its most immediate application in the emergency treatment of active variceal haemorrhage refractory to standard medical and endoscopic therapy, as there is no satisfactory treatment currently available for this high-risk group. TIPS may also have a role in patients awaiting liver transplantation who bleed from varices. Long-term patency should not be an issue in this patient group and portal decompression may reduce blood transfusion requirements during transplant surgery.
McCormick
P A
PA
Hepato-biliary and Liver Transplantation Unit, Royal Free Hospital School of Medicine, London, UK.
Dick
R
R
Burroughs
A K
AK
D002986:Clinical Trials as Topic; D006470:Hemorrhage / Q000628:therapy; D006801:Humans; D006975:Hypertension, Portal / Q000628:therapy*; D011170:Portasystemic Shunt, Surgical / Q000009:adverse effects / Q000379:methods*; D014648:Varicose Veins / Q000628:therapy