Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin F (17) and cucurbitacin F (18) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Further, compounds 14 and 17 exhibited remarkable anti-tumor-promotion effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan.
Takasaki
M
M
Tatsumoto
T
T
Kozuka
M
M
Kasai
R
R
Tanaka
O
O
Nie
R L
RL
Tokuda
H
H
Nishino
H
H
Iwashima
A
A
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D004354:Drug Screening Assays, Antitumor; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D010212:Papilloma / Q000382:microbiology / Q000517:prevention & control; D010946:Plants, Medicinal / Q000737:chemistry*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014775:Virus Activation / Q000187:drug effects*
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D013755:Tetradecanoylphorbol Acetate