[The modification of the clastogenic action of 131I in the bone marrow cells of rats immunized with a tularemia vaccine].
The influence of immunization of Wistar rats with the tularemia vaccine (TV) on the clastogenic effect of 131I was studied. The preliminary immunization of rats with TV significantly reduces the number of aberrant metaphases in bone marrow cells by 36.4% one day and by 61.6% eight days after the administering of the radionuclide in comparison with non-immunized animals. Possible mechanisms of anticlasterogenesis in animals immunized with TV are discussed.
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D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D001853:Bone Marrow / Q000528:radiation effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D005604:Francisella tularensis / Q000276:immunology*; D007114:Immunization; D007457:Iodine Radioisotopes / Q000494:pharmacology*; D008297:Male; D009153:Mutagens; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001428:Bacterial Vaccines; D007457:Iodine Radioisotopes; D009153:Mutagens
Modifikatsiia klastogennogo deĭstviia 131I v kletkakh kostnogo mozga krys, immunizirovannykh tuliaremiĭnoĭ vaktsinoĭ.