[Effect of insulin and adrenaline on the activity of enzymes of glutathione metabolism and glutathione concentration in rat organs].
Adrenaline activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the kidneys, and has no effect on glutathione reductase; no changes in the brain detected. Insulin does not influence glutathione reductase either, nor does it induce any changes in the heart, liver, and bone marrow, but it alters (as a rule reduces) in a number of cases the activities of many glutathione metabolism enzymes and reduces glutathione concentration in the brain, kidneys, and spleen both an hour and 24 h after injection. The detected changes do not conform to universally acknowledged classification of the organs by insulin sensitivity and do not correlate with hypoglycemia.
Kolesnichenko
L S
LS
Kulinskiĭ
V I
VI
Ias'ko
M V
MV
Pensionerova
G A
GA
Grudinina
Iu V
IuV
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D010084:Oxidation-Reduction; D051381:Rats; D014781:Viscera / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D007328:Insulin; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005978:Glutathione; D004837:Epinephrine
Vliianie insulina i adrenalina na aktivnost' fermentov metabolizma glutationa i ego kontsentratsiiu v organakh krys.