title: The SNF/SWI family of global transcriptional activators.
abstract: The yeast SNF/SWI proteins have a global role in transcriptional activation. This set of five proteins assists many gene-specific activators, most likely by altering chromatin structure to relieve repression. Recent work shows that the SNF/SWI proteins function together in a multiprotein complex and that SNF2 has DNA-dependent ATPase activity. SNF/SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation.
authors.affiliation: Department of Genetics and Development, Columbia University, New York, NY 10032.
authors.forename: M
authors.initials: M
authors.lastname: Carlson
authors.forename: B C
authors.initials: BC
authors.lastname: Laurent
mesh_terms: D000818:Animals; D002868:Chromosomal Proteins, Non-Histone; D004247:DNA / Q000235:genetics; D004271:DNA, Fungal / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D051379:Mice; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D015533:Transcriptional Activation
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004271:DNA, Fungal; D005656:Fungal Proteins; C078562:SWI1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D004247:DNA