Effect of a single dose (10 mg) of zolpidem on visual and spectral analysis of sleep in young poor sleepers.
Four non-consecutive nights of sleep were recorded in eight young volunteers complaining of chronic poor sleep. The subjects received a placebo or a 10 mg zolpidem dose prior to bedtime according to a Latin square double-blind design. All-night spectral analyses of the Cz-Pz lead were associated to the standard polysomnography. According to the visual scoring performed with the Rechtschaffen and Kales criteria, zolpidem significantly increased the stage 4 amount and reduced waking. Compared to placebo no difference in sleep stages was observed when the scoring was based on the power in the 0.7 to 4-Hz band. In zolpidem nights power was significantly reduced in the 4 to 8-Hz band during NREM (stages 2, 3 and 4) and was increased in the 2 to 4-Hz band during REM sleep. A significant reduction of fast activities over 12 Hz was observed during the first 3 h of sleep. Concerning slow wave activity, the only change noted was a significant slowing of its build-up rate at the beginning of cycle 1.
Benoit
O
O
Laboratoire d'étude du sommeil, INSERM U296, Bâtiment Pharmacie-Laboratoires, Hôpital de la Salpêtrière, Paris, France.
Bouard
G
G
Payan
C
C
Borderies
P
P
Prado
J
J
D000328:Adult; D003700:Delta Rhythm; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D017286:Polysomnography / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000523:psychology*; D000077334:Zolpidem
D006993:Hypnotics and Sedatives; D011725:Pyridines; D000077334:Zolpidem