[Activity profile of beta blockers].
Beta-adrenergic blockers are heterogeneous with respect to their array of specific actions. Major characteristics of a compound's profile include beta-1 specificity, hydrophilicity, duration of action, antiarrhythmic potency, and intrinsic sympathomimetic activity (ISA). Hydrophilicity parallels duration of action, and beta-1 specificity is inversely related to the strength of metabolic effects. An ideal profile of a beta-adrenergic blocker encompasses high beta-1 specificity, long action, strong antiarrhythmic effects, and low ISA.
Drexel
H
H
Departement für Innere Medizin, Universitätsspital, Zürich.
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D018342:Receptors, Adrenergic, beta-1 / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D018342:Receptors, Adrenergic, beta-1
Wirkungsprofil der Betablocker.