[Development of anticancer-agent-releasing microcapsules for chemotherapy combined with embolo-hyperthermic therapy].
For the purpose of combining chemotherapy with embolo-hyperthermic therapy, we have developed microcapsules made of ferro-magnetic amorphous metal flakes that are additionally capable of releasing anticancer agents. The capsules can be used in a suspension to infuse them into a tumor with transcatheter arterial embolization (TAE). The capsules generate heat in an alternating magnetic field (185 kHz), which avoids heat generation by the body itself. At a certain intensity of the magnetic field, the maximum temperature of the capsule is determined by the Curie point of the amorphous metal. After reaching the maximum temperature, the capsule maintains the temperature by itself within an accuracy of +/- 0.5 degree C. In animal experiments, the capsules generated sufficient heat for interstitial hyperthermia. The tissue concentration of the anticancer agent after TAE with the capsules is maintained at 10 to 20 times higher than that after intraarterial infusion of the anticancer agent solution. These results suggest the usefulness of this method for embolo-hyperthermic therapy combined with intensive chemotherapy without invasive temperature measurement.
Masai
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A
Department of Radiology, Fukushima Medical College.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002214:Capsules; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004285:Dogs; D006979:Hyperthermia, Induced / Q000379:methods*
D000970:Antineoplastic Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D002945:Cisplatin