[The single-dose screening of nitrates, calcium antagonists, beta-adrenoblockaders and their combinations in patients with stenocardia of effort by using the paired bicycle ergometry method].
Fifteen males with stable angina pectoris were screened for efficacy of antianginal drugs in single doses (isosorbide dinitrate, 10 mg; nifedipine, 20 mg; propranolol, 40 mg) and in combinations (ID+Pr, ID+Nf, Nf+Pr, Nf+Pr+ID). The findings at paired bicycle ergometries indicated that ID was most beneficial in monotherapy. Only two combinations (Nf+Pr and Nf+Pr+ID) were superior when compared to single drugs. Combinations ID+Pr and ID+Nf had the same efficacy as ID. Interaction of the drugs assessed with two-dimensional variance analysis was insignificant in all the combinations. Nf+Pr+ID combination had no advantages over two-drug combinations and induced worse tolerance.
Kukushkin
S K
SK
Kokurina
E V
EV
Metelitsa
V I
VI
Bochkareva
E V
EV
Vygodin
V A
VA
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000704:Analysis of Variance; D000787:Angina Pectoris / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000009:adverse effects; D002908:Chronic Disease; D004341:Drug Evaluation; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005080:Exercise Test / Q000187:drug effects / Q000379:methods / Q000706:statistics & numerical data; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage* / Q000009:adverse effects; D005082:Physical Exertion / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D009566:Nitrates
Skrining razovykh doz nitratov, antagonistov kal'tsiia, beta-adrenoblokatorov i ikh kombinatsiĭ u bol'nykh stenokardieĭ napriazheniia s pomoshch'iu metoda parnykh veloérgometriĭ.