title: Inotropic and haemodynamic effects of d- and d,l-sotalol: comparison with other antiarrhythmics.
abstract: The inotropic effects of sotalol in comparison to other antiarrhythmic drugs were tested in an experimental model allowing isovolumic measurements independently of the loading conditions. All class I drugs had a similar negative inotropic effect. d,l-Sotalol caused a dose-dependent depressant effect on the rate of left ventricular pressure development. The same held true for l-sotalol. In contrast, d-sotalol, in clinical doses, revealed no significant inotropic effects in normal hearts. In a postischemic model, d-sotalol led to a further deterioration of left ventricular function. It could be demonstrated by autonomic blockade that this effect was mainly the result of the remaining weak beta-blocking activity of the d-isomer in addition to its class III action. After intravenous administration of amiodarone in doses of 10 mg.kg-1, no significant inotropic effects were found in normal rats.
authors.affiliation: Department of Cardiology, Medical Hospital, University of Tuebingen, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Seipel
authors.forename: H M
authors.initials: HM
authors.lastname: Hoffmeister
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000145:classification / Q000494:pharmacology*; D003864:Depression, Chemical; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013015:Sotalol / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D013015:Sotalol