title: [Severity and reversibility of axial bone loss in primary hyperthyroidism: postoperative densitometric follow-up of 10 patients].
abstract: This study was designed to evaluate axial bone mineral density changes associated with primary hyperparathyroidism before and after parathyroidectomy. Twenty patients who had removal of a parathyroid adenoma were studied. Mean age was 64 +/- 8 years. Bone mineral density was measured preoperatively in all 20 patients and at least 12 months postoperatively in 10 patients. Measurement sites were the lumbar spine (n = 20), femoral neck (n = 6), and/or whole body (n = 6). Preoperatively, mean bone mineral density was decreased at all measurement sites as compared with normal age- and sex-specific values (mean z-score-1 for the lumbar spine and femoral neck and -1.6 for the whole body). Lumbar bone mineral density increased post-operatively in all patients. Bone gain was most marked during the first six months after surgery. Twelve months after surgery, mean lumbar bone mineral density increase was 10.5 +/- 10.2% (n = 10). However reversal of bone loss after surgery was incomplete (z-score at the lumbar spine -0.92 DS +/- 1.04 12 months after surgery).
authors.affiliation: Service de Rhumatologie et de Pathologie Osseuse et de l'Unité INSERM 234, Lyon.
authors.forename: J
authors.initials: J
authors.lastname: Jalby
authors.forename: P J
authors.initials: PJ
authors.lastname: Meunier
mesh_terms: D000368:Aged; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging* / Q000209:etiology; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000209:etiology; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003720:Densitometry; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D005500:Follow-Up Studies; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011877:Radionuclide Imaging; D013997:Time Factors
vernacular_title: Ampleur et réversibilité de la perte osseuse axiale dans l'hyperparathyroïdie primitive: suivi densitométrique post-opératoire chez 10 patients.