t(8;13) (p11;q12) translocation in a myeloproliferative disorder associated with a T-cell non-Hodgkin lymphoma.
An unusual cytogenetic translocation, t(8;13) (p11;q12), is described in a patient presenting with a CML-like myeloproliferative disorder associated with a high-grade T-cell lymphoma. Evidence is presented suggesting that the breakpoint region in the translocation involves a site implicated in both the T cell malignancy and the abnormal granulocyte proliferation.
Leslie
J
J
Department of Haematology, Norfolk and Norwich Hospital.
Barker
T
T
Glancy
M
M
Jennings
B
B
Pearson
J
J
D000368:Aged; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D014178:Translocation, Genetic