Neuroleptics differentially induce jun family genes in the rat striatum.
The effect of neuroleptics in single administration on the expression of genes of the jun family was studied in the rat striatum. jun B, but not jun D was dose-dependently and transiently induced. This effect was blocked by pretreatment with a specific dopamine D2 agonist. The expression of c-jun was also stimulated, although this did not reach statistical significance. Thus dopamine D2 receptors differentially regulate the expression of jun family members in the striatum.
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Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires UPR 416 du CNRS, Centre de Neurochimie, Strasbourg, France.
Malviya
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D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D016758:Genes, jun; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000187:drug effects*
D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2