Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide.
Influence of alpha-receptor blockade on the time-dependent change in the effect of furosemide (a loop diuretic agent) was examined. Furosemide (30 mg/kg) was given orally to the doxazosin (an alpha 1-blocker)- or vehicle-treated rats at 12 AM or 12 PM. Urine volume and urinary excretions of of sodium and furosemide for 8 hr were significantly greater at 12 AM than at 12 PM in the vehicle-treated animals. However, such time-dependent changes in these parameters disappeared in the doxazosin-treated rats. These results suggest that the alpha 1-receptor-mediated stimuli are involved in the mechanism of the time-dependent change in the effect of furosemide.
Fujimura
A
A
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Shiga
T
T
Sudoh
T
T
Ohashi
K
K
Ebihara
A
A
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D017292:Doxazosin / Q000494:pharmacology; D005665:Furosemide / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine; D013997:Time Factors
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D005665:Furosemide; D012964:Sodium; D017292:Doxazosin