[Changes in serum lipoprotein cholesterol in rabbit model of calcium bilirubinate cholangiolithiasis].
The lithogenic process of cholangiolithasis is still not understood clearly. In this study, several serum lipoprotein cholesterol, the bile BA level, etc. in the rabbit model of calcium bilirubinate cholangiolithiasis was examined. The main results included: (1) The concentrations of HDL-ch and HDL2-ch in the serum decreased in all the experimental groups (P < 0.01; P < 0.05), except HDL-ch in the BO 1W group (P > 0.05) compared with the control group. The concentrations of HDL2-ch in the BOI 1W and the BOI 6W groups were lower than those in the BO 1W and the BO 6W groups respectively (P < 0.05); the both concentrations of Fch and HDL3-ch in the BOI and the BO groups were much higher than those in the control group (P < 0.01). (2) The bile T-BA level was lower in the both BOI groups than that in the control group (P < 0.05). It began to decrease in the BO group during the first week, but it was not significant in statistical difference (P > 0.05). During the 6th week the level of the bile acid (BA) was much lower than that in the control group (P < 0.05). According to the above results, it may be concluded that in the formation of calcium bilirubinate gallstones, caused by the biliary obstruction and infection, there is a disorder in the lipoprotein metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)
Chen
N
N
Fu
L
L
Xiao
L
L
D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001649:Bile Duct Diseases / Q000097:blood; D001663:Bilirubin / Q000378:metabolism; D002769:Cholelithiasis / Q000097:blood* / Q000737:chemistry; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D008297:Male; D011817:Rabbits
D001647:Bile Acids and Salts; D008076:Cholesterol, HDL; D001663:Bilirubin