Vasoconstrictors during pregnancy--in vitro trial on pregnant and nonpregnant mouse uterus.
In an in vitro trial on 80 pregnant and nonpregnant mice, the sensitivity of the uterus myometrium to the vasoconstrictors vasopressin, ornipressin, epinephrine, and norepinephrine was examined in comparison with oxytocin as a standardized stimulative drug. The pregnant uterus showed a significantly increased sensitivity to ornipressin, vasopressin, and norepinephrine. Epinephrine showed no uterus-stimulating effect, and an increase of sensitivity caused by pregnancy was not detected.
Stepke
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MT
Klinik für Kiefer-Gesichts-Chirurgie, Eberhard-Karls-Universität Tübingen, Germany.
Schwenzer
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Eichhorn
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D000818:Animals; D004361:Drug Tolerance; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D051379:Mice; D009215:Myometrium / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D009951:Ornipressin / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014667:Vasopressins / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D014667:Vasopressins; D009951:Ornipressin; D009638:Norepinephrine; D004837:Epinephrine