Interactive effects of fluoride and aluminum uptake and accumulation in bones of rabbits administered both agents in their drinking water.
Fluoride (F) and aluminum (Al), which are known to form a strong complex, are both present in finished drinking water. The effect of F and AI on one another's tissue accumulation was determined using adult male New Zealand white rabbits. Thirty-six rabbits (three per group) were given Purina Rabbit Chow and drinking water containing no F or AI, F alone (1, 4, or 50 ppm F as NaF), Al alone, (100 or 500 ppm Al as AlCl3), or a combination of F and Al, ad libitum for 10 wk. None of these treatments altered food intake or weight gain in these rabbits. However, rabbits treated with 1 ppm F and 500 ppm Al consumed significantly less water than control rabbits. The F accumulation in plasma, urine, incisors, and tibia was increased as the F addition to the drinking water increased within groups receiving a single concentration of Al. In contrast, F accumulation in plasma, urine, incisors, and tibia decreased as the Al concentration increased within groups receiving a single F concentration, indicative of decreased intestinal absorption. Importantly, Al levels in tibia were significantly increased by the addition of F to the drinking water, even in animals receiving no Al in their drinking water. The effect of F on Al accumulation in bone was confirmed by our evaluating Al levels in sterna harvested from rats treated with 0 or 79 ppm F (as NaF in the drinking water) in a study conducted by the National Toxicology Program (Bucher et al., 1991). Therefore, some of the osteotoxicity seemingly associated with high F levels in bone may be due to the accumulation of Al or an Al-F complex.
Ahn
H W
HW
Institute for Environmental Studies, University of Illinois, Urbana 61801.
Fulton
B
B
Moxon
D
D
Jeffery
E H
EH
D000535:Aluminum / Q000097:blood / Q000652:urine; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001682:Biological Availability; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D005260:Female; D005459:Fluorides / Q000097:blood / Q000652:urine; D007180:Incisor / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D011817:Rabbits; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D013249:Sternum / Q000187:drug effects / Q000378:metabolism*; D013977:Tibia / Q000187:drug effects / Q000378:metabolism*; D014018:Tissue Distribution
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D012969:Sodium Fluoride; D000535:Aluminum; D005459:Fluorides