Neuropeptide Y infusion decreases plasma renin activity in postmyocardial infarction rats.
We wished to determine if chronic neuropeptide Y (NPY) infusion (1 ng/min for 1 week by Alzet minipump) could decrease plasma renin activity (PRA) and norepinephrine (NE) in a rat myocardial infarction (MI) model of moderate compensated congestive heart failure (CHF). CHF was produced by prior (6-8 weeks) ligation of the left coronary artery; control rats were sham-operated. Carotid arterial blood was drawn for PRA and NE in conscious unrestrained rats that had been instrumented 24 h earlier. MI rats had increased PRA as compared with sham-operated rats [8.73 +/- 1.27 vs. 5.10 +/- 0.91 ng angiotensin (AI) I/ml.h, mean +/- SE]. During chronic NPY infusion, PRA was reduced to normal in the MI group (4.78 +/- 0.91) but was not affected in the sham group (5.65 +/- 0.51). Plasma NE was altered similarly, but the changes did not reach statistical significance. These data suggest that NPY has the capacity to restrain renin release in moderate compensated CHF.
Zelis
R
R
Department of Medicine, Pennsylvania State University, College of Medicine, Hershey.
Nussberger
J
J
Clemson
B
B
Waeber
B
B
Grouzmann
E
E
Brunner
H R
HR
D000818:Animals; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000097:blood*; D007262:Infusions, Intravenous; D008297:Male; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000097:blood*; D009478:Neuropeptide Y / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood*
D009478:Neuropeptide Y; D012083:Renin; D009638:Norepinephrine