Effects of trichothecene mycotoxins on the ex vivo vascular smooth muscle responses to beta-adrenergic agonists.
The ex vivo biophysical response of isolated rat aorta to T-2 toxin, diacetoxyscirpenol (DAS) and Roridin-A were determined. Roridin-A caused a dose-dependent relaxation of precontracted (30 mM KCl) aorta, while T-2 toxin and DAS were without effect. On the other hand, the relaxation response of aorta to isoproterenol and sodium fluoride is impaired in the presence of T-2 toxin or DAS. Roridin-A did not alter the relaxation response to isoproterenol or sodium fluoride. These experiments suggest that macrocyclic trichothecenes (e.g., Roridin-A) are capable of altering vascular smooth muscle tone directly, while simple trichothecenes (e.g., T-2 toxin, DAS) interfere with beta-adrenergic responses.
Kimbrough
T D
TD
Department of Biomedical Sciences, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg.
Weekley
L B
LB
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009183:Mycotoxins / Q000633:toxicity*; D051381:Rats; D013605:T-2 Toxin / Q000633:toxicity; D014255:Trichothecenes / Q000633:toxicity
D000318:Adrenergic beta-Agonists; D009183:Mycotoxins; D014255:Trichothecenes; D013605:T-2 Toxin; C038849:roridin A; C001809:diacetoxyscirpenol