title: The changing epidemiology of invasive bacterial infections in Massachusetts children, 1984 through 1991.
abstract: Coincident with the licensure of Haemophilus influenzae b conjugate vaccines from 1987 to 1990, the incidence of meningitis and other invasive infections caused by H influenzae type b declined in Massachusetts children by 87% and 91%, respectively. By 1991, Neisseria meningitidis had replaced H influenzae b as the leading cause of bacterial meningitis, accounting for 57% of cases. During the period 1984 through 1991, serogroup C displaced sero-group B as the most common cause of N meningitidis disease. Streptococcus pneumoniae caused 92% of nonmeningitis invasive disease, with sero-groups 14, 6, 19, 18, 4, 23, and 9 causing 94.5% of infections. These findings have implications for the development of additional polysaccharide-protein conjugate vaccines for the prevention of childhood infections.
authors.affiliation: Massachusetts Public Health Biologic Laboratories, Boston.
authors.forename: A M
authors.initials: AM
authors.lastname: Loughlin
authors.forename: C D
authors.initials: CD
authors.lastname: Marchant
authors.forename: S M
authors.initials: SM
authors.lastname: Lett
mesh_terms: D001428:Bacterial Vaccines; D002675:Child, Preschool; D015331:Cohort Studies; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D007223:Infant; D008404:Massachusetts / Q000453:epidemiology; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000517:prevention & control; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000517:prevention & control; D011159:Population Surveillance; D012044:Regression Analysis; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000517:prevention & control; D018074:Vaccines, Conjugate
chemical_list: D001428:Bacterial Vaccines; D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate