title: Haemopoietic stem/progenitor cell transplant in Fanconi anaemia using HLA-matched sibling umbilical cord blood cells.
abstract: There have only been a few reports documenting the use of umbilical cord blood as a source of stem cells for haemopoietic reconstitution. We report our experience with a child with Fanconi anaemia (FA) who underwent a stem cell transplant using umbilical cord blood cells from his HLA matched sibling. Although the engraftment was somewhat slow, it was complete and comparable to other transplants performed in FA patients using HLA matched sibling marrow. There was no graft-versus-host disease. The post-transplant period was uncomplicated and, at a follow-up of 36 months, this child is well with normal blood counts and immune function.
authors.affiliation: Division of Pediatric Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-2899.
authors.forename: M
authors.initials: M
authors.lastname: Kohli-Kumar
authors.forename: N T
authors.initials: NT
authors.lastname: Shahidi
authors.forename: H E
authors.initials: HE
authors.lastname: Broxmeyer
authors.forename: M
authors.initials: M
authors.lastname: Masterson
authors.forename: C
authors.initials: C
authors.lastname: Delaat
authors.forename: J
authors.initials: J
authors.lastname: Sambrano
authors.forename: C
authors.initials: C
authors.lastname: Morris
authors.forename: A D
authors.initials: AD
authors.lastname: Auerbach
authors.forename: R E
authors.initials: RE
authors.lastname: Harris
mesh_terms: D002675:Child, Preschool; D002873:Chromosome Fragility; D005199:Fanconi Anemia / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D005312:Fetal Blood / Q000166:cytology*; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000032:analysis*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male
chemical_list: D006680:HLA Antigens