title: [Antibiotherapy in the past, present and future].
abstract: The antibiotic era started in 1941. Several antibiotics were obtained from the fermentation broth, either from moulds (penicillin) or from Actinomyces species (erythromycin). Numerous antibacterial agents were prepared synthetically such as benzylpyrimidines, 4-quinolones, nitroheterocyclic derivatives, have been developed. Consecutive "waves" of newer antibiotics was helpful to solve some infectious problems but simultaneous emergence of resistant strains has occurred amongst initially susceptible bacteria. This imposes reconsideration of our therapeutic armamentarium and a search for new compounds as well as for new concepts in anti-infective therapy.
authors.affiliation: Laboratoire de Microbiologie, Centre Hospitalier Victor Dupouy, Argenteuil.
authors.forename: A
authors.initials: A
authors.lastname: Bryskier
mesh_terms: D000900:Anti-Bacterial Agents / Q000266:history* / Q000627:therapeutic use; D002511:Cephalosporins / Q000266:history; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D010406:Penicillins / Q000266:history; D012106:Research
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins
vernacular_title: L'Antibiothérapie au passé, au présent et au futur.