The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases.
A variety of experimental approaches are currently being evaluated for controlling CD4+ T helper 1 (Th1)-mediated autoimmune pathology. Here, Stephen Miller and William Karpus compare and contrast the efficacies of various antigen-specific regulatory strategies. Particular emphasis is placed on the mechanisms of peripheral immune tolerance and how this may be used in the treatment and analysis of the pathologic T-cell repertoire in autoimmune and virus-induced demyelinating diseases.
Miller
S D
SD
Dept of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611.
Karpus
W J
WJ
D000818:Animals; D003711:Demyelinating Diseases / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*