Lipid metabolism: implications of alpha 1-blockade.
Four points summarize the apparent major effects of selective alpha 1-inhibitors on lipid metabolism: stimulation of lipoprotein lipase; reduced VLDL synthesis and secretion; increase in the number of LDL receptors; and perhaps also a decrease in LDL cholesterol synthesis. Similar to the experimental data, the issues concern the type of patient, the clinical condition, normality, high cholesterol values or high triglyceride values, a combination of both, hypertension, and the degree of sympathetic activity.
Rosenthal
J
J
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001581:Benzothiadiazines; D002318:Cardiovascular Diseases / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004232:Diuretics; D006801:Humans; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000096:biosynthesis; D008079:Lipoproteins, VLDL / Q000096:biosynthesis; D008954:Models, Biological; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004232:Diuretics; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D011942:Receptors, Adrenergic, alpha; D049993:Sodium Chloride Symporter Inhibitors