title: Prognostic value of the activated partial thromboplastin time after orthotopic liver transplantation. A prospective study.
abstract: In this prospective study, we evaluated the predictive value of activated partial thromboplastin time on day 8 post transplantation for event-free survival in patients who had had orthotopic liver transplants; both death and retransplantation within 6 months were the events considered. In a 4-year period, 109 patients had orthotopic liver transplants in our hospital, and 104 were eligible for the study since they survived and were not given new transplants within 8 days. The activated partial thromboplastin time was significantly longer in patients who survived event-free for less than 6 months than in those with longer event-free survivals. Kaplan-Meier curves showed that patients with normal activated partial thromboplastin times were nine times more likely to survive more than 6 months without events than patients with prolonged values. The positive predictive value of activated partial thromboplastin time for event-free survival was 88% and the negative predictive value was 54%, indicating that the test is useful for predicting patient outcome. We suggest that activated partial thromboplastin time be performed on day 8 post transplantation to predict the medium-term event-free survival.
authors.affiliation: Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, Milan, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Martinelli
authors.forename: M
authors.initials: M
authors.lastname: Moia
authors.forename: B
authors.initials: B
authors.lastname: Gridelli
authors.forename: D
authors.initials: D
authors.lastname: Panzeri
authors.forename: M
authors.initials: M
authors.lastname: Langer
authors.forename: P M
authors.initials: PM
authors.lastname: Mannucci
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016031:Liver Transplantation / Q000401:mortality / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate