[Effect of HLA compatibility on kidney transplantation].
The influence of the HLA system on the success rate of kidney transplantations was evaluated in a worldwide collaborative study. The results confirm the influence of the HLA chromosome on transplants from related donors. Moreover, a highly significant effect of compatibility for the HLA-A, -B, -DR antigens was observed in cadaver transplants (p < 0.0001). The great importance of a good quality of tissue typing was emphasized by a) the observation that a significant influence of compatibility for the HLA-A, -B antigens was evident only if donors and recipients were typed for 'split' specificities and not when they were typed for 'broad' antigens, and b) an improved effect of HLA-DR compatibility when serological typing errors were corrected by molecular (DNA) typing. Computations show that kidney allocation according to the best possible HLA compatibility results in a gain of 800 transplant function years per 1,000 transplantations over a 10-year period.
Opelz
G
G
Institut für Immunologie, Universität Heidelberg.
Wujciak
T
T
Back
D
D
Mytilineos
J
J
Schwarz
V
V
Albrecht
G
G
D002102:Cadaver; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology / Q000401:mortality; D006650:Histocompatibility Testing; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000276:immunology* / Q000401:mortality; D012307:Risk Factors; D015996:Survival Rate
Einfluss der HLA-Kompatibilität auf die Nierentransplantation.