title: Activation by peptidases and cytotoxicity of 2-(L-alpha-aminoacyl) prodrugs of methotrexate.
authors.affiliation: Department of Pharmacy, University of Sydney, NSW, Australia.
authors.forename: H T
authors.initials: HT
authors.lastname: Cheung
authors.forename: Z
authors.initials: Z
authors.lastname: Dong
authors.forename: L
authors.initials: L
authors.lastname: Escoffier
authors.forename: M A
authors.initials: MA
authors.lastname: Smal
authors.forename: M H
authors.initials: MH
authors.lastname: Tattersall
mesh_terms: D000215:Acylation; D000596:Amino Acids; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D001407:Bacillus / Q000201:enzymology; D018826:CD13 Antigens; D002470:Cell Survival / Q000187:drug effects; D010450:Endopeptidases / Q000378:metabolism*; D005493:Folic Acid Antagonists; D007668:Kidney / Q000201:enzymology; D007780:Lacticaseibacillus casei / Q000201:enzymology; D007939:Leukemia L1210; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D011355:Prodrugs / Q000378:metabolism* / Q000633:toxicity*; D011751:Pyroglutamyl-Peptidase I / Q000378:metabolism; D013329:Structure-Activity Relationship; D013552:Swine; D014407:Tumor Cells, Cultured
chemical_list: D000596:Amino Acids; D005493:Folic Acid Antagonists; D011355:Prodrugs; D010450:Endopeptidases; D000626:Aminopeptidases; D018826:CD13 Antigens; D011751:Pyroglutamyl-Peptidase I; D008727:Methotrexate