[Levosulpiride versus domperidone in the treatment of functional dyspepsia].
Levosulpiride, a dopaminergic antagonist was compared in a double-blind randomized study with domperidone for treatment of functional dyspepsia in 50 patients divided into two groups of 25 subjects each. Group I received 25 mg levosulpiride 3 times daily, group II received 10 mg domperidone 3 times daily, all for 30 days. Periodic clinical examination at days 0, 7, 15, 30 showed symptomatic changes. Gallbladder and gastric emptying was studied by ultrasonography at the start and end of treatment. Both drugs had a positive influence on dyspeptic symptoms and on gastric and gallbladder emptying, but the latter parameters were improved significantly more effectively by levosulpiride. As to tolerability, there have been 3 drop-outs and a further 6 patients complained of sides effects that did not require suspension of treatment.
Mangiameli
A
A
Istituto di Medicina Interna A. Francaviglia, Università degli Studi di Catania.
Brogna
A
A
Catanzaro
R
R
Sofia
M
M
Blasi
A
A
D000328:Adult; D001549:Benzamides / Q000494:pharmacology / Q000627:therapeutic use*; D004294:Domperidone / Q000494:pharmacology / Q000627:therapeutic use*; D015259:Dopamine Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011759:Pyrrolidines / Q000494:pharmacology / Q000627:therapeutic use*; D013469:Sulpiride / Q000031:analogs & derivatives*
D001549:Benzamides; D015259:Dopamine Agents; D011759:Pyrrolidines; D004294:Domperidone; D013469:Sulpiride; C078143:levosulpiride
Levosulpiride vs domperidone nel trattamento della dispepsia funzionale.