Prolactin secretion following repetitive seizures.
We studied serum prolactin levels after 24 seizures occurring in eight subjects. Video-EEG intracranial monitoring confirmed temporal or frontal partial seizures. Seizure type, focus, and duration were similar for seizures with and without significant postictal prolactin elevations. The seizure-free interval (the time between seizures) varied considerably. Seizures occurring after longer seizure-free intervals (31.75 to 240 hours) showed robust prolactin responses. After shorter seizure-free intervals (1.07 to 25.42 hours), prolactin responses were reduced. This suggests that the amount of releasable prolactin is limited, depleted by seizures, or perhaps inhibited by prolactin feedback. Seizure-free intervals should be considered when interpreting prolactin levels.
Malkowicz
D E
DE
Department of Neurology, Mid-Atlantic Regional Epilepsy Center, Medical College of Pennsylvania, Philadelphia 19129.
Legido
A
A
Jackel
R A
RA
Sussman
N M
NM
Eskin
B A
BA
Harner
R N
RN
D000328:Adult; D002648:Child; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000097:blood / Q000503:physiopathology*; D004833:Epilepsy, Temporal Lobe / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood* / Q000378:metabolism; D012008:Recurrence
D011388:Prolactin