title: A patient-to-computed-tomography image registration method based on digitally reconstructed radiographs.
abstract: An automatic method for the accurate registration of computed tomography (CT) data with two camera-calibrated radiographs is presented. The registration is based on the skull as visualized both in the plain radiographs and in radiographs digitally reconstructed from CT. A reference coordinate system is established based on the radiographic projection parameters obtained using an angiographic stereotactic localizer. The CT-derived reconstructed radiographs are aligned iteratively at multiple resolutions until a best match is found by adjusting the position and orientation of the CT data set relative to the reference coordinate system. The results of experiments with a skull phantom performed under stereotactic control which show that reliable registration is possible with an accuracy better than 1 mm are presented. Possible applications include intraoperative patient-to-CT frameless registration and registration of radiographic data with frameless CT for depth electroencephalogram electrode position confirmation.
authors.affiliation: Department of Clinical Neurology, Institute of Neurology, London, United Kingdom.
authors.forename: L
authors.initials: L
authors.lastname: Lemieux
authors.forename: R
authors.initials: R
authors.lastname: Jagoe
authors.forename: D R
authors.initials: DR
authors.lastname: Fish
authors.forename: N D
authors.initials: ND
authors.lastname: Kitchen
authors.forename: D G
authors.initials: DG
authors.lastname: Thomas
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D003365:Costs and Cost Analysis; D006801:Humans; D008961:Models, Structural; D008962:Models, Theoretical; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D012886:Skull / Q000000981:diagnostic imaging; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed / Q000379:methods*