[In vivo effects of anti-cam antibody on OA sensitized rats].
To determine the role of cell adhesion molecules, we evaluated the in vivo effects of anti-intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (1A29) and anti-leukocyte function associated molecule-1 (LFA-1) monoclonal antibody (WT-1) on ovalbumin (OA) sensitized rats. Both sneezing discharges and nasal rubbing movements after nasal OA challenge were significantly inhibited by these monoclonal antibody administrations (control vs treated group; 20.5 +/- 5.0 vs 7.0 +/- 2.9 times/minutes, p < 0.01 and and 56.8 +/- 7.1 vs 26.9 +/- 2.9 times/15 minutes, p < 0.01, for sneezing and rubbing, respectively). The number of eosinophils in nasal mucosa 24 hours after the challenge was also inhibited by the treatment (control vs treatment group; 108.8 +/- 27.3 vs 13.8 +/- 6.9 p < 0.01). These results suggest some pathophysiological roles of ICAM-1 and LFA-1 in nasal allergy.
Saitoh
H
H
Department of Otorhinolaryngology, Sapporo Medical University.
Asakura
K
K
Kataura
A
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000502:physiology*; D004195:Disease Models, Animal; D018799:Intercellular Adhesion Molecule-1; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology / Q000502:physiology*; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000628:therapy
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1; D010047:Ovalbumin