The radiation chemistry of d(CpGpTpA) in the presence of oxygen.
This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradiated in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligomers guanine is hydroxylated at the 8-position and an adjacent pyrimidine is degraded to a formamido remnant.
Budzinski
E E
EE
Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York 14263.
Dawidzik
J D
JD
Wallace
J C
JC
Freund
H G
HG
Box
H C
HC
D004249:DNA Damage; D009838:Oligodeoxyribonucleotides / Q000528:radiation effects*; D010100:Oxygen / Q000494:pharmacology*
D009838:Oligodeoxyribonucleotides; D010100:Oxygen