Monitoring of fibrin and fibrinogen degradation products (FDP) in the cerebrospinal fluid of patients with subarachnoid haemorrhage due to ruptured aneurysm. Report of 55 cases.
Fibrin and fibrinogen degradation products in the cerebrospinal fluid (CSF-FDP) were first studied in a group of 29 patients observed during the first and the second week after subarachnoid hemorrhage (SAH), then in a second group of 26 patients for a total of 55 patients. In the latter group only the first FDP value obtained as soon as possible after SAH was taken in consideration. In the whole series of 55 patients several noteworthy factors were found: 1) FDP determination should be performed as soon as possible after SAH; 2) CSF-FDP at or above 40, 80 micrograms/ml was found both in the patients with severe neurological deficits and in those with cerebral ischemia (statistically significant); 3) the significance of CSF-FDP in patients who rebled was also evaluated. In conclusion CSF-FDP could be considered useful in predicting cerebral ischemia.
Schisano
G
G
Department of Neurosurgery, Ospedale Nuovo Pellegrini, Naples, Italy.
Franco
A
A
Nina
P
P
Papa
M L
ML
Iannuzzi
M
M
De Biase
R
R
Caldora
M
M
D017542:Aneurysm, Ruptured / Q000150:complications*; D015415:Biomarkers; D002545:Brain Ischemia / Q000134:cerebrospinal fluid* / Q000209:etiology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D003244:Consciousness Disorders / Q000134:cerebrospinal fluid / Q000209:etiology; D003289:Convalescence; D005337:Fibrin / Q000134:cerebrospinal fluid; D005338:Fibrin Fibrinogen Degradation Products / Q000134:cerebrospinal fluid*; D005342:Fibrinolysis; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D002546:Ischemic Attack, Transient / Q000134:cerebrospinal fluid / Q000209:etiology; D012008:Recurrence; D012422:Rupture, Spontaneous; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000401:mortality
D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D005338:Fibrin Fibrinogen Degradation Products; D005337:Fibrin