Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.
The actin cytoskeleton appears to be as the cellular target of various clostridial ADP-ribosyltransferases which have been described during recent years. Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin and Clostridium spiroforme toxin ADP-ribosylate actin monomers and inhibit actin polymerization. Clostridium botulinum exoenzyme C3 and Clostridium limosum exoenzyme ADP-ribosylate the low-molecular-mass GTP-binding proteins of the Rho family, which participate in the regulation of the actin cytoskeleton. ADP-ribosylation inactivates the regulatory Rho proteins and disturbs the organization of the actin cytoskeleton.
Aktories
K
K
Institut für Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg-Saar, Germany.
D036002:ADP Ribose Transferases / Q000378:metabolism; D000199:Actins / Q000737:chemistry; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D001427:Bacterial Toxins / Q000494:pharmacology*; D001905:Botulinum Toxins; D003013:Clostridium; D019204:GTP-Binding Proteins / Q000378:metabolism*; D013379:Substrate Specificity
D000199:Actins; D001427:Bacterial Toxins; D000246:Adenosine Diphosphate Ribose; D000255:Adenosine Triphosphate; D036002:ADP Ribose Transferases; C063007:exoenzyme C3, Clostridium botulinum; D001905:Botulinum Toxins; D019204:GTP-Binding Proteins