Generation of activated protein C during thrombolysis.
The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 micrograms/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation--the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.
Gruber
A
A
Scripps Research Institute, La Jolla, CA 92037.
Pál
A
A
Kiss
R G
RG
Sas
G
G
Griffin
J H
JH
D000368:Aged; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D011486:Protein C / Q000032:analysis / Q000096:biosynthesis* / Q000378:metabolism; D018046:Protein C Inhibitor / Q000097:blood; D013300:Streptokinase / Q000494:pharmacology* / Q000627:therapeutic use; D015912:Thrombolytic Therapy
D011486:Protein C; D018046:Protein C Inhibitor; D013300:Streptokinase