title: Effect of chloroquine on rat liver mitochondria.
abstract: Chloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy.
authors.affiliation: Department of Biochemistry, University of Madras, India.
authors.forename: P D
authors.initials: PD
authors.lastname: Deepalakshmi
authors.forename: K
authors.initials: K
authors.lastname: Parasakthy
authors.forename: S
authors.initials: S
authors.lastname: Shanthi
authors.forename: N S
authors.initials: NS
authors.lastname: Devaraj
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002738:Chloroquine