title: Experimental study by fluorescence microscopy and microangiography of remodeling and regeneration of bone inside alloplastic contour augmentations.
abstract: Five female Göttingen minipigs received unilateral subperiosteal implantation of a block of porous hydroxyapatite covered by a polylactic membrane. Five months later, biopsies were taken from the blocks, which were left in place for another 3 months. The biopsies showed bone formation in all pores, indicating complete penetration of the blocks after 5 months. Highly vascular tissue with radiographic signs of bone resorption was found in the upper third of the augmentation 3 months later. Fluorescence microscopy showed that all sequential labels were present throughout the whole block. However, a significant decrease in the frequency of the 1-week label was recorded, showing that elevation of the overlying soft tissue may lead to temporary impairment of vascular supply.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Medical School, Hanover, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schliephake
authors.forename: C
authors.initials: C
authors.lastname: Kröly
authors.forename: H
authors.initials: H
authors.lastname: Wüstenfeld
mesh_terms: D000792:Angiography; D000818:Animals; D001672:Biocompatible Materials; D016723:Bone Remodeling / Q000502:physiology*; D005260:Female; D048091:Guided Tissue Regeneration; D006882:Hydroxyapatites; D008334:Mandible / Q000098:blood supply / Q000601:surgery*; D008833:Microcirculation; D008856:Microscopy, Fluorescence; D019736:Prostheses and Implants; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites