title: Foscarnet for suppression of human immunodeficiency virus replication.
abstract: The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic foscarnet exposure by a maximum-effect pharmacodynamic model.
authors.affiliation: Department of Pharmacy Practice, University of Minnesota, Minneapolis.
authors.forename: C V
authors.initials: CV
authors.lastname: Fletcher
authors.forename: A C
authors.initials: AC
authors.lastname: Collier
authors.forename: F S
authors.initials: FS
authors.lastname: Rhame
authors.forename: D
authors.initials: D
authors.lastname: Bennett
authors.forename: M F
authors.initials: MF
authors.lastname: Para
authors.forename: C C
authors.initials: CC
authors.lastname: Beatty
authors.forename: C E
authors.initials: CE
authors.lastname: Jones
authors.forename: H H
authors.initials: HH
authors.lastname: Balfour
mesh_terms: D000328:Adult; D001499:Bayes Theorem; D015496:CD4-Positive T-Lymphocytes; D004311:Double-Blind Method; D005260:Female; D017245:Foscarnet / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015488:HIV Antigens / Q000032:analysis; D015658:HIV Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D015488:HIV Antigens; D017245:Foscarnet