Stability of DNA fingerprint pattern produced with IS6110 in strains of Mycobacterium tuberculosis.
To assess the stability of IS6110 restriction fragment length polymorphism patterns, DNA fingerprints of 6 Mycobacterium bovis isolates from 1 patient and of 41 Mycobacterium tuberculosis isolates from 18 patients were compared. The fingerprint pattern for a given patient remained identical or nearly identical despite recovery of the isolates during intervals which ranged from 8 months to 4.5 years. Changes in drug resistance profile did not alter a strain's fingerprint pattern.
Cave
M D
MD
Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock 72205.
Eisenach
K D
KD
Templeton
G
G
Salfinger
M
M
Mazurek
G
G
Bates
J H
JH
Crawford
J T
JT
D016172:DNA Fingerprinting; D004251:DNA Transposable Elements / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics; D016680:Genome, Bacterial; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D012150:Polymorphism, Restriction Fragment Length; D013045:Species Specificity; D013183:Sputum / Q000382:microbiology; D014376:Tuberculosis / Q000382:microbiology*; D014556:Urine / Q000382:microbiology
D004251:DNA Transposable Elements; D004269:DNA, Bacterial