title: Influence of chronic stretching upon rat soleus muscle during non-weight-bearing conditions.
abstract: Morphological, contractile and histochemical properties as well as the myosin heavy chain (MHC) composition of rat soleus muscles were studied after 14 days of non-weight-bearing (NWB) and after immobilization of the foot in dorsiflexion of NWB rats. Significant reductions in soleus mass, fibre sizes and tetanic tension were found after 14 days of NWB. Furthermore, a transformation of the slow-twitch soleus muscle towards a faster type was characterized by a decrease in twitch time parameters, an increase in the fast-twitch type IIA fibre proportion and an increase in fast-twitch type MHC isoforms. Our results showed that the immobilization of the soleus muscle in a lengthened position during NWB not only prevented the loss of muscular mass and force output, but also counteracted the slow to faster shift in contractile and phenotypical parameters normally associated with NWB conditions.
authors.affiliation: Laboratoire de Physiologie des Structures Contractiles, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
authors.forename: D
authors.initials: D
authors.lastname: Leterme
authors.forename: C
authors.initials: C
authors.lastname: Cordonnier
authors.forename: Y
authors.initials: Y
authors.lastname: Mounier
authors.forename: M
authors.initials: M
authors.lastname: Falempin
mesh_terms: D000818:Animals; D007103:Immobilization; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology* / Q000648:ultrastructure; D009210:Myofibrils / Q000502:physiology; D009218:Myosins / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009218:Myosins