title: The association of tuberculosis and HIV infection in Harare, Zimbabwe.
abstract: METHODS
  The tuberculosis (TB) service responsible for all TB treatment in Harare, Zimbabwe.
  
  
  OBJECTIVE
  (1) To determine HIV seroprevalence among TB patients and controls. (2) To compare clinical and demographic characteristics of HIV-infected and uninfected TB patients.
  
  
  METHODS
  Cohort study. Entry criterion: TB diagnosed during the 18 month study period. Assessment included HIV serology. Matched community controls were HIV serotested.
  
  
  RESULTS
  In 1434 TB patients tested, HIV seroprevalence was 48% in men and 44% in women, peaked in the 25-34 year age group and was higher than in controls (relative risk [RR] = 3.1, 95% confidence interval [CI] = 2.6-3.7). In adults, seroprevalence was 34%, 49% and 58% in successive 6 month periods. A history of entry of prior TB treatment was less common in the HIV-seropositive (RR = 0.57, CI = 0.37-0.88). In adults, tuberculin negativity, TB at 2 sites, lymph node, pericardial and miliary TB, hilar adenopathy and pleural effusion were significantly more common in HIV-seropositive patients; cavitation and upper lobe involvement were significantly less frequent. Pulmonary TB and sputum smear positivity had similar frequencies in the 2 groups.
  
  
  CONCLUSIONS
  HIV was strongly and increasingly associated with TB in Harare and altered the clinical and radiologic features of TB. Failed standard TB treatment in HIV-infected individuals contributed minimally to new cases of TB.
authors.affiliation: University of Zimbabwe School of Medicine, Harare.
authors.forename: S
authors.initials: S
authors.lastname: Houston
authors.forename: S
authors.initials: S
authors.lastname: Ray
authors.forename: M
authors.initials: M
authors.lastname: Mahari
authors.forename: P
authors.initials: P
authors.lastname: Neill
authors.forename: W
authors.initials: W
authors.lastname: Legg
authors.forename: A S
authors.initials: AS
authors.lastname: Latif
authors.forename: J
authors.initials: J
authors.lastname: Emmanuel
authors.forename: M
authors.initials: M
authors.lastname: Bassett
authors.forename: A
authors.initials: A
authors.lastname: Pozniak
authors.forename: S
authors.initials: S
authors.lastname: Tswana
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D015528:HIV Seroprevalence; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017678:Sex Distribution; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D015030:Zimbabwe / Q000453:epidemiology