A single-blind comparison of bromperidol and sulpiride in hospitalized schizophrenics.
Fourty-five schizophrenic inpatients were randomly assigned to bromperidol or sulpiride in an 8 week single-blind clinical trial. No statistically significant differences were observed for final global improvement rating. Regarding BPRS items and compared to sulpiride, bromperidol was particularly effective to relieve emotional withdrawal and hallucinatory behavior, although the only significant between group difference was in favour of sulpiride for improvements of somatic concern. No significant differences were observed for all PES items, although sulpiride was found more effective for hypochondriasis and neurotic complaint as was bromperidol for hallucination and disturbance of self-conscious. The rate of side-effects and abnormal laboratory test results were comparable in the two groups. They were not severe enough to require termination of administration. Bromperidol and sulpiride are concluded to have different clinical profile in the treatment of schizophrenic hospitalized patients.
Yamagami
S
S
Department of Neuropsychiatry, Osaka Citi University Medical School, Japan.
Hirayama
E
E
Mui
K
K
Okuno
M
M
Kioka
T
T
Soma
T
T
Ohno
K
K
D000328:Adult; D010054:Brief Psychiatric Rating Scale; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D016037:Single-Blind Method; D013469:Sulpiride / Q000009:adverse effects / Q000627:therapeutic use*
D013469:Sulpiride; D006220:Haloperidol; C006820:bromperidol