Elevated concentrations of circulating ICAM-1 in far advanced and miliary tuberculosis.
Intercellular adhesion molecule-1 (ICAM-1) plays an important role in inflammatory diseases. Cellular expression and shedding of ICAM-1 are up-regulated by cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). With an ELISA containing two monoclonal antibodies to human ICAM-1, we measured concentrations of circulating ICAM-1 in patients with tuberculosis. Prominently elevated values were found in miliary tuberculosis and in far advanced pulmonary tuberculosis but not in minimal or moderately advanced disease. The measurement of serum IFN-gamma and TNF-alpha also revealed high concentrations of the cytokines in miliary tuberculosis and far advanced pulmonary tuberculosis. The circulating ICAM-1 values were significantly correlated to serum IFN-gamma and TNF-alpha values. In the case of miliary tuberculosis and far advanced pulmonary tuberculosis treated with antituberculous drugs, the circulating ICAM-1 concentrations were gradually decreased to correspond with improvement of clinical symptoms and chest X-ray findings. The measurement of circulating ICAM-1 is useful to evaluate the severity of tuberculosis and to monitor disease activity during antituberculous drug treatment.
Shijubo
N
N
Department of Internal Medicine, Sapporo Medical University, Japan.
Imai
K
K
Nakanishi
F
F
Yachi
A
A
Abe
S
S
D000328:Adult; D000368:Aged; D015815:Cell Adhesion Molecules / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma / Q000097:blood; D008875:Middle Aged; D014391:Tuberculosis, Miliary / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015815:Cell Adhesion Molecules; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma