[The effect of pharmaceutic aids on gidazepam biotransformation and bioavailability].
When gidazepam was administered to rats in combination with 4% solutions of Tween 80 or polyvinylpyrrolidone, its bioavailability was higher than its combination with 4% polyethylene glycol 400 solution, as shown by high performance liquid chromatography. Increasing the quantities of these high-molecular compounds in gidazepam solutions was demonstrated to enhance gidazepam dealkylation in the animals after oral administration.
Otabekova
S G
SG
Kolyvanov
G B
GB
Zherdev
V P
VP
Litvin
A A
AA
Vyrovshchikova
S M
SM
D000818:Animals; D014151:Anti-Anxiety Agents / Q000032:analysis / Q000493:pharmacokinetics*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000032:analysis / Q000493:pharmacokinetics*; D001682:Biological Availability; D001711:Biotransformation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003640:Dealkylation; D008297:Male; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D051381:Rats; D012996:Solutions
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D010592:Pharmaceutic Aids; D012996:Solutions; D001569:Benzodiazepines; C077010:gidazepam
Vliianie vspomogatel'nykh veshchestv na biotransformatsiiu i biodostupnost' gidazepama.