Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes.
Antigen and cytokine receptors induce rapid tyrosine phosphorylation of receptor subunits, other membrane proteins, and signaling components. Each receptor induces phosphorylation of a number of proteins. Although there is often overlap between targets of different receptors, any given receptor only induces phosphorylation of a subset of possible targets. How this choice of targets is achieved for these receptors is not yet understood. The cellular events downstream of some signaling components are beginning to come into view. Recent progress in these areas is discussed.
DeFranco
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GW Hooper Foundation, University of California, San Francisco 94143-0552.
D000818:Animals; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*; D014443:Tyrosine / Q000378:metabolism*
D014443:Tyrosine