Perioperative drug interactions.
The various classes of IV and inhalation anesthetics all appear to potentiate one another. Many of these interactions are clinically useful in outpatient anesthesia, and many are quite predictable. True synergy is most likely to occur when two drugs produce similar actions by slightly different mechanisms. These principles are particularly well demonstrated by the interactions of hypnotic drugs at the locus ceruleus. It is possible that the reduced anesthetic requirements seen in some disease states may involve similar mechanisms.
Michalowski
P
P
Department of Anesthesia, Massachusetts General Hospital, Boston 02114.
Rosow
C E
CE
D000316:Adrenergic alpha-Agonists; D000771:Anesthesia, Intravenous; D001569:Benzodiazepines; D004347:Drug Interactions; D004357:Drug Synergism; D006801:Humans; D006993:Hypnotics and Sedatives; D009294:Narcotics
D000316:Adrenergic alpha-Agonists; D006993:Hypnotics and Sedatives; D009294:Narcotics; D001569:Benzodiazepines