A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1).
The major locus for autosomal dominant polycystic kidney disease (PKD1) is located in a gene-rich region on chromosome 16p13.3. Recently the identification of the gene responsible for PKD1 has been described. While searching for candidate genes in this region, we isolated a new member of the cyclin family. We have characterized the transcript by sequencing, determination of the exon intron boundaries, and Northern blot analysis. Cyclin F is related to A- and B-type cyclins by sequence, but its function is unknown.
Kraus
B
B
Imperial Cancer Research Fund, London, United Kingdom.
Pohlschmidt
M
M
Leung
A L
AL
Germino
G G
GG
Snarey
A
A
Schneider
M C
MC
Reeders
S T
ST
Frischauf
A M
AM
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D016213:Cyclins / Q000737:chemistry / Q000235:genetics*; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics*; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D050396:TRPP Cation Channels
D016213:Cyclins; D018076:DNA, Complementary; D011506:Proteins; D050396:TRPP Cation Channels; C503669:CCNF protein, human