Metastatic papillary carcinoma of thyroid in a patient undergoing allogeneic BMT for CML.
A 30-year-old woman underwent HLA-compatible bone marrow transplant for chronic myeloid leukaemia. Her post-transplant course was complicated by disseminated aspergillus and CMV infections resulting in death 65 d post transplant. At post-mortem, multiple pulmonary metastases of papillary carcinoma of the thyroid were found with a small (< 8 mm) primary carcinoma in the thyroid. It is suggested that the progression of this tumour was related to the patient's immunocompromised state.
Morrison
A E
AE
Department of Haematology, Royal Infirmary of Edinburgh.
O'Grady
J
J
Parker
A C
AC
McLaren
K
K
D000328:Adult; D016026:Bone Marrow Transplantation; D002291:Carcinoma, Papillary / Q000276:immunology / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology*