The stress response and autoimmunoregulation.
Using the recent burgeoning of information on how the stress response systems interact, and combining this with advances in our understanding of neuroimmune communication, a proposed neuroendocrine-neuroimmune stress response system incorporating autoimmunoregulation is reviewed. The study of immunocyte behavior in certain clinical conditions associated with a variant stress response may help illuminate the functioning of the neuroendocrine-neuroimmune stress response system.
Fricchione
G L
GL
Division of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Stefano
G B
GB
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D003863:Depression / Q000503:physiopathology; D004723:Endorphins / Q000502:physiology; D005790:General Adaptation Syndrome / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000503:physiopathology; D008032:Limbic System / Q000503:physiopathology; D008125:Locus Coeruleus / Q000503:physiopathology; D016131:Lymphocyte Subsets / Q000276:immunology; D008954:Models, Biological; D015213:Neuroimmunomodulation; D018377:Neurotransmitter Agents / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D013312:Stress, Physiological / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology
D016207:Cytokines; D004723:Endorphins; D018377:Neurotransmitter Agents; D003346:Corticotropin-Releasing Hormone