Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.
Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT. Dopamine D2 receptor occupancy 1.5 months after withdrawal still amounted to 83% and 50%. More attention should be focused on long term effects of neuroleptics.
Harasko-van der Meer
C
C
Neurological University Clinic, Vienna, Austria.
Brücke
T
T
Wenger
S
S
Fischer
P
P
Deecke
L
L
Podreka
I
I
D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000503:physiopathology; D003692:Delayed-Action Preparations; D065127:Dopamine D2 Receptor Antagonists; D005260:Female; D005476:Fluphenazine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012563:Schizophrenia, Paranoid / Q000150:complications / Q000188:drug therapy; D015899:Tomography, Emission-Computed, Single-Photon
D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D065127:Dopamine D2 Receptor Antagonists; C011825:fluphenazine depot; D005476:Fluphenazine