[Limited value of the apomorphine test in Parkinson disease].
OBJECTIVE
To determine the predictive value of the subcutaneous apomorphine test for the effect of dopaminergic drugs in the treatment of Parkinson's disease.


METHODS
Retrospective and literature study.


METHODS
University Hospital Leiden, the Netherlands.


METHODS
All articles regarding apomorphine administration in Parkinson's disease were reviewed. The data were compared with the results of apomorphine tests performed between October 1990 and September 1992 in the Leiden University Hospital.


RESULTS
The positive predictive value for good clinical efficacy of dopaminergic medication was 85%, lower than the results from the literature (96%). The negative predictive value was 58% (in the literature 75%), with a sensitivity of 73% and a specificity of 73%.


CONCLUSIONS
These predictive values are poor and practical problems with the test are substantial. Little indication remains for the application of the apomorphine challenge test.
Roos
R A
RA
Academisch Ziekenhuis, afd. Neurologie, Leiden.
van Laar
T
T
van Hilten
J J
JJ
D000368:Aged; D001058:Apomorphine / Q000008:administration & dosage; D015259:Dopamine Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies
D015259:Dopamine Agents; D001058:Apomorphine
Beperkte waarde van de apomorfinetest bij de ziekte van Parkinson.