[Intercellular adhesion molecule 1 antigen in tuberculosis].
Intercellular adhesion molecule 1 (ICAM-1) plays an important role in inflammatory diseases. We investigated levels of circulating soluble ICAM-1 in patients with miliary tuberculosis (n = 8) and pulmonary tuberculosis (n = 49). We also attempted to compare ICAM-1 levels among pulmonary tuberculosis patients according to chest X ray classification of the Japanese Society for Tuberculosis. Significantly increased levels of circulating ICAM-1 were found in patients with miliary tuberculosis and extensive (extent 3) pulmonary tuberculosis (n = 9) compared to those of controls (n = 48), but not in patients with extent 1 (n = 24) or extent 2 pulmonary tuberculosis (n = 16). Immunohistochemical examination of the tuberculous lung tissues from the patients showed intensive cellular ICAM-1 on epithelioid cells and giant cells as well as on vascular endothelial cells. These results suggest that ICAM-1 is an important adhesion molecule in tuberculosis.
Shijubo
N
N
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Hirasawa
M
M
Inuzuka
M
M
Asakawa
M
M
Abe
S
S
Imai
K
K
D000328:Adult; D000368:Aged; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1; D008168:Lung / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012995:Solubility; D014376:Tuberculosis / Q000276:immunology*; D014391:Tuberculosis, Miliary / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology
D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1