title: [Cryptorchism. Treatment with human chorionic gonadotropin or gonadotropin-releasing hormone?].
abstract: In a modified double-blind study on the effect of human chorionic gonadotrophin (hCG), gonadotrophin releasing hormone (GnRH) and placebo, 163 prepubertal boys (aged 1.8-13.0) with bilateral and 94 (aged 1.5-13.1 years) with unilateral cryptorchidism fulfilled the inclusion criteria and completed the treatment protocol. hCG was administered as intramuscular injections twice weekly for three weeks. GnRH and placebo were given intranasally. hCG was superior to GnRH and placebo in the treatment of both bilateral (p < 0.0016) and unilateral (p < 0.013) cryptorchidism with success rates of respectively 23% and 19%. Linear and logistic regression analysis on the results obtained by treatment of bilateral disease showed that all treatments were more successful the younger the age of the boys. The data indicated that bilateral and unilateral cryptorchidism respond differently to hormonal treatment. We conclude that the success rates obtained in this study justify the use of hCG in prepubertal boys with cryptorchidism.
authors.affiliation: Børneafdelingen, Hvidovre Hospital, København.
authors.forename: P
authors.initials: P
authors.lastname: Christiansen
authors.forename: J R
authors.initials: JR
authors.lastname: Müller
authors.forename: S B
authors.initials: SB
authors.lastname: Buhl
authors.forename: O R
authors.initials: OR
authors.lastname: Hansen
authors.forename: N
authors.initials: N
authors.lastname: Hobolth
authors.forename: B B
authors.initials: BB
authors.lastname: Jacobsen
authors.forename: P I
authors.initials: PI
authors.lastname: Jørgensen
authors.forename: K W
authors.initials: KW
authors.lastname: Kastrup
authors.forename: K
authors.initials: K
authors.lastname: Nielsen
authors.forename: L B
authors.initials: LB
authors.lastname: Nielsen
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D003456:Cryptorchidism / Q000188:drug therapy*; D004311:Double-Blind Method; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D011446:Prospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone
vernacular_title: Kryptorkisme. Behandling med human chorion gonadotropin eller gonadotropinfrigørende hormon?