title: Reduction of depolarization-induced glutamate release by heme oxygenase inhibitor: possible role of carbon monoxide in synaptic transmission.
abstract: The effects of carbon monoxide on the release of glutamate were studied in synaptoneurosomal preparations using a fluorometric system. Zinc protoporphyrin IX, an inhibitor of the heme oxygenase that produces carbon monoxide, reduced depolarization-induced glutamate release in a calcium-dependent manner, but had no effect on calcium-independent glutamate release. On the basis of this finding, we suggest that carbon monoxide plays a pivotal role in glutamate release in synapses, and may be a retrograde messenger in long-term potentiation.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shinomura
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D002248:Carbon Monoxide / Q000494:pharmacology*; D004594:Electrophysiology; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors*; D017774:Long-Term Potentiation / Q000502:physiology; D008297:Male; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism; D011189:Potassium Chloride / Q000494:pharmacology; D011524:Protoporphyrins / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D005971:Glutamates; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D018698:Glutamic Acid; D011189:Potassium Chloride; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing); D002118:Calcium