Influence of idazoxan on the dopamine D2 receptor agonist-induced behavioural effects in rats.
The behavioural effects in rats of the dopamine D2 receptor agonists, lisuride, B-HT 920 and SND 919, were variously influenced by pre-treatment with the selective alpha 2-adrenoceptor antagonist, idazoxan (2 mg/kg), depending on the nature of the effect in question and the doses of agonist employed. The influence of idazoxan on drug-induced stretching-yawning, penile erection, sedation, stereotyped behaviour, aggressiveness and mounting is described and tentatively interpreted in neurochemical terms, account being taken of the activity of respective alpha 2-adrenoceptor antagonist and dopamine receptor agonists used, at alpha 2-adrenoceptors and at different dopamine D2 receptor subtypes, pre- and postsynaptically located.
Ferrari
F
F
Institute of Pharmacology, University of Modena, Italy.
Giuliani
D
D
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D052160:Benzothiazoles; D004146:Dioxanes / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019329:Idazoxan; D008090:Lisuride / Q000494:pharmacology; D008297:Male; D000077487:Pramipexole; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000378:metabolism; D013239:Stereotyped Behavior / Q000187:drug effects; D013844:Thiazoles / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D001381:Azepines; D052160:Benzothiazoles; D004146:Dioxanes; D015259:Dopamine Agents; D017448:Receptors, Dopamine D2; D013844:Thiazoles; C024763:talipexole; D000077487:Pramipexole; D008090:Lisuride; D019329:Idazoxan