[Antibodies to neuromediators in allergic diseases (pollinosis)].
Sera from 33 pollinosis patients aged 16-33 have been examined for autoantibodies to neuromediators serotonin and catecholamine, serum samples from 21 healthy subjects served controls. Antibodies to dopamine and norepinephrine (43.0 +/- 4.0, 35.0 +/- 0.0 rel. units) have been detected in 81.8% and 69.7% of the pollinosis patients, respectively. Serotonin antibodies (54.6 +/- 6.0 rel. units) occurred in the patients 3.8 times more frequently than in healthy subjects. Antibodies to neuromediators in quantities within 12.0 rel. units were recorded in 9.5-38.0% of the controls. It is suggested that induction of neuromediator antibodies synthesis may represent a compensatory mechanism of neuromediator metabolism control in pollinosis.
Evseev
V A
VA
Vetrilé
L A
LA
Mukhina
G L
GL
Basharova
L A
LA
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002908:Chronic Disease; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D018377:Neurotransmitter Agents / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*
D001323:Autoantibodies; D018377:Neurotransmitter Agents; D007073:Immunoglobulin E
Antitela k neĭromediatoram pri allergicheskikh zabolevaniiakh (pollinoze).