title: The clinical pathology of heartwater. III. Changes in blood clotting, blood calcium, blood protein, haematocrit and white-cell counts in sheep with experimentally induced heartwater.
abstract: Studies to evaluate changes in blood clotting, blood calcium and protein, the haematocrit and white-cell counts were undertaken in seven sheep with experimentally induced heartwater. A marked decline in thrombocyte count was recorded during the acute stage of the disease. This was associated with increases in both prothrombin time (PT) and activated partial thromboplastin time (APTT); fibrinogen increased while there was no detectable increase in fibrinogen degradation products (FDP). At the same time total serum protein (TSP), albumin and globulin dropped very sharply; total calcium showed a progressive drop but ionized calcium rose initially and was followed by a terminal decline. The total leucocyte count showed a terminal increase while the haematocrit dropped progressively.
authors.affiliation: Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
authors.forename: S R
authors.initials: SR
authors.lastname: Van Amstel
authors.forename: F
authors.initials: F
authors.lastname: Reyers
authors.forename: E
authors.initials: E
authors.lastname: Myburgh
authors.forename: G
authors.initials: G
authors.lastname: Pretorius
authors.forename: P
authors.initials: P
authors.lastname: Sacks
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006357:Heartwater Disease / Q000097:blood*; D006400:Hematocrit / Q000662:veterinary; D007958:Leukocyte Count / Q000662:veterinary; D010314:Partial Thromboplastin Time / Q000662:veterinary; D011517:Prothrombin Time / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood*
chemical_list: D001798:Blood Proteins; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D002118:Calcium