Induction of heat shock protein 70 and glial fibrillary acidic protein in the postischemic gerbil hippocampus.
Immunohistochemical changes of heat shock protein 70 (HSP 70) and glial fibrillary acidic protein (GFAP) were investigated in the gerbil hippocampus 1 h-7 days after 10 min of cerebral ischemia. Transient cerebral ischemia caused HSP 70 expression in GFAP-positive astrocytes in a delayed fashion, as compared with a rapid induction in vulnerable neurons such as hilar neurons. The present results may offer clues to elucidate the mechanisms of ischemic neuronal damage.
Araki
T
T
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Kato
H
H
Liu
X H
XH
Kogure
K
K
Itoyama
Y
Y
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D005849:Gerbillinae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006624:Hippocampus; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons
D005904:Glial Fibrillary Acidic Protein; D006360:Heat-Shock Proteins