Hepatic changes of mice in the subacute phase of streptozotocin (SZ)-induced diabetes.
Hepatic changes of mice in the subacute phase of streptozotocin (SZ)-induced diabetes were investigated biochemically and pathologically. Biochemically, the contents of serum glucose and of serum and liver lipids increased while the content of liver glycogen decreased in SZ-induced diabetic mice. Histopathologically, hypertrophy of hepatocytes due to an increase in number of intracytoplasmic acidophilic granules was common to SZ-induced diabetic mice. Electron microscopically, these hepatocytes were characterized by a prominent increase in number of mitochondria showing normal structure, a marked decrease of glycogen granules and poorly developed rough endoplasmic reticulum, which were common to so-called oncocytic cells. In some SZ-induced diabetic mice, bile duct hyperplasia with an appearance of cytomegalic hepatocytes was also observed.
Kume
E
E
Research Laboratory of Drug Metabolism, Tanabe Seiyaku Co. Ltd., Saitama, Japan.
Ohmachi
Y
Y
Itagaki
S
S
Tamura
K
K
Doi
K
K
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000473:pathology*; D004721:Endoplasmic Reticulum / Q000187:drug effects; D006003:Glycogen / Q000032:analysis; D006984:Hypertrophy / Q000473:pathology; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008854:Microscopy, Electron; D009929:Organ Size / Q000187:drug effects; D013311:Streptozocin / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
D001786:Blood Glucose; D008055:Lipids; D013311:Streptozocin; D006003:Glycogen