Fibrinolysis and elastic compression: no fibrinolytic effect of elastic compression in healthy volunteers.
The local and systemic fibrinolytic response to the placing of elastic compression in healthy volunteers was studied to determine whether this method of preventing venous thromboembolism has any profibrinolytic effect, as previously demonstrated with intermittent pneumatic compression. Variations in the major parameters of fibrinolysis (euglobulin lysis time, t-PA antigen, PAI-1 antigen, PAI-1 activity) were studied in an open randomized cross-over study in 21 healthy volunteers, in which three types of treatment were tested for periods of 24 h each (without elastic compression, elastic compression of an upper limb, elastic compression of the lower limbs). Four blood samples were taken from the upper limb during each period (at 08:00 h, 10:00 h, 18:00 h, 08:00 h on the following day). The placing of elastic compression did not cause any statistically significant change in the four parameters tested between the three types of treatment. In contrast, circadian rhythm was confirmed for all the fibrinolytic factors studied with a minimal fibrinolytic activity in the morning and a maximal activity in the evening. Elastic compression does not seem to have any profibrinolytic effect in healthy volunteers but other studies are needed in patients before a definitive conclusion can be reached.
Conchonnet
P
P
Unité de Pharmacologie Clinique, CHU Saint-Etienne, France.
Mismetti
P
P
Reynaud
J
J
Laporte-Simitsidis
S
S
Tardy-Poncet
B
B
Boissier
C
C
Rambaud
C
C
Decousus
H
H
D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D003250:Constriction; D018592:Cross-Over Studies; D004548:Elasticity; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D010507:Periodicity; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D012712:Serum Globulins / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000097:blood
D017395:Plasminogen Activator Inhibitor 1; D012712:Serum Globulins; D010959:Tissue Plasminogen Activator