Hyperphosphatemia in tumor lysis syndrome: the role of hemodialysis and continuous veno-venous hemofiltration.
We report a 4-year-old boy who developed tumor lysis syndrome complicated by severe hyperphosphatemia and acute renal failure, following chemotherapy for T-cell acute lymphoblastic leukemia. Despite successful treatment of hyperphosphatemia with hemodialysis, there was an immediate rebound in the high serum phosphorus level. The patient underwent a second treatment with hemodialysis which was then followed by continuous veno-venous hemofiltration (CVVH). CVVH maintained his serum phosphorus at a stable level until his renal function improved. CVVH can be used in conjunction with hemodialysis to successfully treat the hyperphosphatemia associated with tumor lysis syndrome.
Sakarcan
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A
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75235-9063.
Quigley
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R
D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D000970:Antineoplastic Agents / Q000009:adverse effects; D002675:Child, Preschool; D006440:Hemofiltration; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy; D008297:Male; D010758:Phosphorus / Q000097:blood*; D006435:Renal Dialysis; D015275:Tumor Lysis Syndrome / Q000097:blood / Q000209:etiology*
D000970:Antineoplastic Agents; D010758:Phosphorus