Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection.
Patients with obsessive-compulsive disorder (OCD) demonstrated significant levels of antibody for somatostatin-28, its C-terminal fragment somatostatin-14, and prodynorphin. In contrast there were lower levels of reactivity for somatostatin-28(1-14) (the N-terminal fragment of somatostatin-28) and negligible reactivity for several other peptides including beta-endorphin and corticotropin. Healthy volunteers and disease controls [schizophrenia, Alzheimer's disease, multiple sclerosis, and subjects with advanced human immunodeficiency virus (HIV) infection] exhibited negligible reactivity. These data raise the consideration of an autoimmune mechanism for some OCD.
Roy
B F
BF
Psychiatry Service, Veterans Affairs Medical Center, Albany, NY 12208.
Benkelfat
C
C
Hill
J L
JL
Pierce
P F
PF
Dauphin
M M
MM
Kelly
T M
TM
Sunderland
T
T
Weinberger
D R
DR
Breslin
N
N
D000328:Adult; D000544:Alzheimer Disease / Q000276:immunology*; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology; D015551:Autoimmunity; D001667:Binding, Competitive; D004745:Enkephalins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology*; D009771:Obsessive-Compulsive Disorder / Q000276:immunology*; D011498:Protein Precursors / Q000276:immunology*; D012559:Schizophrenia / Q000276:immunology*; D013004:Somatostatin / Q000276:immunology*
D000906:Antibodies; D004745:Enkephalins; D011498:Protein Precursors; D013004:Somatostatin; C033660:preproenkephalin