[Induction of autoantibodies to serotonin and catecholamines in chronically morphine addicted rats with manifestations of abstinence syndrome].
The possibility of formation of autoantibodies to neurotransmitters has been studied in experimental model of opiate addiction. Chronic treatment of rats with morphine that leads to formation of dependence, causes induction of antibodies to norepinephrine, dopamine and serotonin. The latter could be considered as indicators of impaired neurotransmitter metabolism. Induction of autoantibodies to neurotransmitters could be a sort of defence mechanism in opiate addiction.
Basharova
L A
LA
Evseev
V A
VA
Vetrilé
L A
LA
Trekova
N A
NA
Gamaleia
N B
NB
Veretinskaia
A G
AG
Tronnikov
S I
SI
D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000096:biosynthesis*; D002395:Catecholamines / Q000276:immunology* / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D009021:Morphine Dependence / Q000276:immunology*; D018377:Neurotransmitter Agents / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000276:immunology* / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000276:immunology*; D013997:Time Factors
D001323:Autoantibodies; D002395:Catecholamines; D018377:Neurotransmitter Agents; D012701:Serotonin
Induktsiia autoantitel k serotoninu i katekholaminam u khronicheski morfinizirovannykh krys s proiavleniem abstinentnogo sindroma.