title: A non-linear fitting program in pharmacokinetics with Microsoft Excel spreadsheet.
abstract: We propose a new approach of pharmacokinetics patterns of drugs by use of spreadsheets. We have developed a software program using Microsoft Excel (version 3.0) to determine initial poly exponential parameter values for 1-3 compartment open models and to make non-linear regression with many optimisation procedures. Results are compared with 2 other programs: Nonlin and Rugfit.
authors.affiliation: AH-AU, Hôpital Sainte-Marguerite, Service de Médecine Interne, Marseille, France.
authors.forename: H
authors.initials: H
authors.lastname: Delboy
mesh_terms: D000284:Administration, Oral; D000465:Algorithms; D003196:Computer Graphics; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D016014:Linear Models; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010599:Pharmacokinetics; D012984:Software; D014018:Tissue Distribution
chemical_list: D004364:Pharmaceutical Preparations