[EcoRV-polymorphism of human mitochondrial DNA].
Restriction fragment length polymorphism (RFLP) of EcoRV fragments of mitochondrial DNA (mtDNA) from placenta tissue of eighty one inhabitants of Magadan Sity, seventy one of which are of East-Slavish origin, was studied. EcoRV-2 morph frequency was 11.1%. We found new variant of human mtDNA EcoRV polymorphism, morph 3, which was formed in consequence of nucleotide substitution in site between 6737 to 6739 base pairs (bp). Results obtained are compared with known data for several races. Mitotype EcoRV-2/HinfI-34/AvaII-3 frequency in various ethnic groups, which was 2.8% in Magadan sample, is presented. The results of morph combination analysis in mitotypes evidenced of conformity of EcoRV-2 morphs to mtDNA types of non-European origin.
Maliarchuk
B A
BA
Balmusheva
N P
NP
Derenko
M V
MV
D004272:DNA, Mitochondrial; D005260:Female; D006801:Humans; D010920:Placenta / Q000502:physiology*; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy
D004272:DNA, Mitochondrial
EcoRV-polimorfizm mitokhondrial'noĭ DNK cheloveka.