Circadian plasma level profile of lisuride in rats and mice after continuous administration via the diet.
Lisuride (Dopergin, CAS 18016-80-3), a dopamine D2 agonist, was administered to male and female rats and mice continuously via the diet for 14 days. The doses were 0.2 mg/kg/d in mice and 1 mg/kg/d in mice and rats. Plasma level profiles (0-22 or 24 h) were determined by measuring lisuride concentrations by radioimmunoassay. At all doses a plateau-like plasma level of lisuride was observed. A clear circadian rhythm of lisuride concentrations (highs during night, low levels during day) was found for male rats (1 mg/kg/d) and for male mice (0.2 mg/kg/d). Female animals did not show this phenomenon as pronounced. At the same dose of 1 mg/kg/d rats showed higher plasma levels than mice. For males the ratio of total AUCs was 1.9 and for female animals 8.6.
Krause
W
W
Research Laboratories of Schering Aktiengesellschaft, Berlin, Fed. Rep. of Germany.
Reissmann
F
F
Kühne
G
G
Schöbel
C
C
D000818:Animals; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm / Q000502:physiology*; D004032:Diet; D004435:Eating; D005260:Female; D006207:Half-Life; D008090:Lisuride / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D008090:Lisuride