Alanine at position 73 of HLA-C is associated with psoriasis vulgaris in Finland.
A close association was found between a specific sequence of HLA-C and psoriasis vulgaris in Finnish patients (chi 2 = 18.4, P = 1.78 x 10(-5)). This sequence codes for alanine at position 73 of the HLA-C molecule in the antigen binding cleft, and alanine may play a role in susceptibility to the disease.
Ikäheimo
I
I
Department of Medical Microbiology, University of Oulu, Finland.
Silvennoinen-Kassinen
S
S
Karvonen
J
J
Tiilikainen
A
A
D000409:Alanine; D001483:Base Sequence; D017931:DNA Primers; D004198:Disease Susceptibility; D005387:Finland; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D011565:Psoriasis / Q000235:genetics*
D017931:DNA Primers; D015236:HLA-C Antigens; D015345:Oligonucleotide Probes; D000409:Alanine