Evolution of a regulatory gene family: HOM/HOX genes.
With the increasing accumulation of data on the presence of the HOM/HOX class of homeobox genes in the animal kingdom, and with new comparative analyses of these data, strong evolutionary conservation is apparent. It is clear that HOM/HOX genes and their roles in pattern formation were established early during the evolution of major phyla. The functional indications that this system is utilized in quite diverged organisms attest to the fundamental roles of homeobox genes in organismal development.
Kappen
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Department of Biochemistry and Molecular Biology, Mayo Clinic/Foundation, Scottsdale, Arizona 85259.
Ruddle
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FH
D000818:Animals; D001181:Arthropods / Q000235:genetics; D005075:Biological Evolution; D005801:Genes, Homeobox; D005809:Genes, Regulator; D014644:Genetic Variation; D005810:Multigene Family; D014714:Vertebrates / Q000235:genetics