[Accumulation of gene alterations and progression of breast cancer].
A number of gene alterations have been detected in human breast cancer, and their clinicopathological implications have been investigated. Amplification of the c-erb B-2 gene and point mutations of the p53 gene are shown to be associated with biological aggressiveness of cancer cells, whereas loss of heterozygosity on chromosome 16q is suggested to be associated with acquirement of malignant phenotype. Because these gene alterations are accumulated frequently even at the preinvasive stage, the genotype as well as phenotype of breast cancer appears to have been determined mostly relatively soon after tumorigenesis.
Tsuda
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Pathology Division, National Cancer Center Research Institute.
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002885:Chromosomes, Human, Pair 16; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D017353:Gene Deletion; D016158:Genes, p53; D006801:Humans; D010641:Phenotype; D017354:Point Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases
D066246:ErbB Receptors; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases