[Effect of somatostatin-14 in simple mechanical obstruction of the small intestine].
In order to investigate the properties of somatostatin-14 we studied an experimental model of simple mechanical and closed loop occlusion. Forty-eight New Zealand rabbits were assigned randomly to three groups of 16: group C (controls) was operated and treated with saline solution (4 cc/Kg/h); group A was operated and initially treated with saline solution and an equal dose of somatostatin-14 (3.5 micrograms/Kg/h; and group B was operated and treated in the same manner as group A, but later, 8 hours after the laparotomy. The animals were sacrificed 24 hours later; intestinal secretion was quantified, blood and intestinal fluid chemistries were performed and specimens of the intestine were prepared for histological examination. Descriptive statistical analysis of the results was performed with the ANOVA, a semi-quantitative test and the covariance test. Somatostatin-14 produced an improvement in the volume of intestinal secretion in the treated groups compared with the control group. The results were statistically significant in group B treated after an 8-hour delay: closed loop (ml): 6.40 +/- 1.12, 2.50 +/- 0.94, 1.85 +/- 0.83 and simple mechanical occlusion (ml): 175 +/- 33.05, 89.50 +/- 9.27, 57.18 +/- 21.23, p < 0.01 for groups C, A and B C, A and B respectively. Net secretion of Cl and Na ions was also improved, p < 0.01.(ABSTRACT TRUNCATED AT 250 WORDS)
Jimenez-Garcia
A
A
Département d'Enseignement de Chirurgie, Hôpital Universitaire Virgen Macarena Seville, Espagne.
Ahmad Araji
O
O
Balongo Garcia
R
R
Nogales Munoz
A
A
Salguero Villadiego
M
M
Cantillana Martinez
J
J
D000818:Animals; D002712:Chlorides / Q000032:analysis; D007262:Infusions, Intravenous; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000473:pathology; D007419:Intestinal Secretions / Q000737:chemistry / Q000187:drug effects*; D011188:Potassium / Q000032:analysis; D011817:Rabbits; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012964:Sodium / Q000032:analysis; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D002712:Chlorides; D012462:Saline Solution, Hypertonic; D013004:Somatostatin; D012964:Sodium; D011188:Potassium
Action de la somastostatine-14 dans l'occlusion mécanique simple de l'intestin grêle.