A possible role of glutamate in the aging process.
Glutamate (Glu) is considered here for its possible role as a naturally occurring mammalian 'age inducing' substance. The existence of 'Glu elicited headaches', may serve as an indication that Glu could negatively affect the human adult CNS. The prevalence of Glu induced headaches was found to be 28.8% in a study population of 201 subjects. Circumstantial similarities between brain aging and Glu toxicity are presented in the paper. Finally, it is mentioned that Vitamin E is partially effective in blocking Glu induced headaches.
Pokras
R S
RS
Pasadena City College, Life Sciences Department, California 91106-2003.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000009:adverse effects / Q000502:physiology*; D018698:Glutamic Acid; D006261:Headache / Q000139:chemically induced; D006801:Humans; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology
D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D014810:Vitamin E; D018698:Glutamic Acid