title: [The effect of priming dose of vecuronium on the diaphragm and the hypothenar muscle].
abstract: We studied the relaxation property of priming or precurarization vecuronium dose (0.015 mg.kg-1) on the diaphragm and the abductor digiti minimi muscle in 8 healthy patients undergoing elective surgery. Patients had control ventilation (PETCO2: 35 - 40 mmHg) by the laryngeal mask under "thiopental-fentanyl-oxygen" anesthesia. Supra-maximal single twitch stimulation with 1 Hz frequency was applied to right phrenic and ulnar nerves. Electromyographic response was recorded using NEC Synax ER1100 (NEC, Sanei, Tokyo, Japan) by surface electrodes in the 8 th intercostal space and the hypothenar. Time to maximum blockade at the diaphragm was 189 +/- 37 sec, compared with 314 +/- 39 at the abductor digiti minimi muscle (P < 0.01). This result suggests that we should be careful about the respiratory state of primed or precurarized patients with small dose of vecuronium such as 0.015 mg.kg-1 administration.
authors.affiliation: Department of Anesthesiology, Nara Medical University, Kashihara.
authors.forename: K
authors.initials: K
authors.lastname: Tatsumi
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Fukushima
authors.forename: T
authors.initials: T
authors.lastname: Einaga
authors.forename: H
authors.initials: H
authors.lastname: Furuya
authors.forename: T
authors.initials: T
authors.lastname: Okuda
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D003964:Diaphragm / Q000187:drug effects; D004576:Electromyography; D005260:Female; D005385:Fingers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D014673:Vecuronium Bromide / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014673:Vecuronium Bromide