Pharmacological stimulation of t-PA release.
The acute release of tissue-type plasminogen activator t-PA from the vascular endothelium is of decisive importance for the prevention of intravascular fibrin deposits. A dose-dependent t-PA release from the isolated perfused vascular preparations may be induced by mediators (platelet-activating factor, bradykinin, histamine) adrenergic and cholinergic transmitters (isoprenaline, acetylcholine), thrombin, heparin and analogues, and 1-desamino-8-D-arginine-vasopression (DDAVP). Most of the compounds were shown to enhance the t-PA activity also in animal experiments (rats, rabbits, mini pigs). The pharmacologic stimulation of the t-PA release may be convenient for short-term thrombosis, prophylaxis and partial thrombolysis. Presently, this could only be achieved by unfractionated and low molecular weight heparins which have been shown to release t-PA.
Klöcking
H P
HP
Institute of Pharmacology and Toxicology, Medical School, Erfurt, Germany.
Markwardt
F
F
D000818:Animals; D001779:Blood Coagulation Factors / Q000494:pharmacology; D004431:Ear, External / Q000187:drug effects / Q000378:metabolism*; D006493:Heparin / Q000031:analogs & derivatives / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013268:Stimulation, Chemical; D013552:Swine; D013556:Swine, Miniature; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
D001779:Blood Coagulation Factors; D018377:Neurotransmitter Agents; D006493:Heparin; D010959:Tissue Plasminogen Activator