Protective action of diosmectite treatment on digestive disturbances induced by intestinal anaphylaxis in the guinea-pig.
METHODS
Colonic transit time, faecal moisture and intestinal permeability were assessed in guinea-pigs sensitized intraperitoneally with cow's milk and challenged with an oral administration of beta-lactoglobulin. One group of animals was treated for 1 week with diosmectite (500 mg.kg/day) and another with placebo. A control group was not sensitized but treated with diosmectite.


RESULTS
In sensitized animals receiving placebo, challenge with beta-lactoglobulin induced a significant (P < 0.05) decrease in colonic transit time, and increases in faecal moisture and intestinal permeability. These changes were not observed in animals treated with diosmectite.


CONCLUSIONS
Diosmectite pre-treatment protects against allergic digestive disturbances induced by antigen administration in guinea-pigs sensitized to cow's milk.
Theodorou
V
V
Department of Pharmacology, Institut National de la Recherche Agronomique, Toulouse, France.
Fioramonti
J
J
Droy-Lefaix
M T
MT
Plique
O
O
Buéno
L
L
D000707:Anaphylaxis / Q000378:metabolism; D000818:Animals; D003106:Colon / Q000378:metabolism; D004066:Digestive System Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D005243:Feces / Q000737:chemistry; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D005772:Gastrointestinal Transit / Q000187:drug effects; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000187:drug effects; D007441:Intubation, Gastrointestinal; D007782:Lactoglobulins / Q000009:adverse effects*; D008297:Male; D016269:Milk Hypersensitivity / Q000150:complications*; D017640:Silicates; D014867:Water / Q000032:analysis
D005765:Gastrointestinal Agents; D007782:Lactoglobulins; D017640:Silicates; D014867:Water; C033214:Smectite