Modification of in vivo Ca(2+)-uptake by parenterally administered aluminum complexes.
The parental administration of complexed aluminum induces a very significant increase of Ca(2+0-uptake by various tissues. The effects are more important with aluminum-ATP complex than with the simultaneous administration of aluminum lactate and sodium ATP. In the last case the increase in calcium uptake does not reach the many fold (up to 7 times) values observed with aluminum-ATP complex. In this aluminum-induced modification of cellular calcium homeostasis ATP appears to act as a mediator of the metal complex effects. These experimental results emphasize the importance of the role of ATP in the biological properties of low molecular weight metal complexes.
Anghileri
L J
LJ
Biophysics Laboratory, Medicine Faculty, University of Nancy, France.
Maincent
P
P
Thouvenot
P
P
D000255:Adenosine Triphosphate / Q000737:chemistry; D000535:Aluminum / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D007273:Injections, Intramuscular; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D051379:Mice
D007773:Lactates; D019344:Lactic Acid; D000255:Adenosine Triphosphate; D000535:Aluminum; D002118:Calcium