Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder.
The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs.
Nishimura
M
M
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Toki
J
J
Sugiura
K
K
Hashimoto
F
F
Tomita
T
T
Fujishima
H
H
Hiramatsu
Y
Y
Nishioka
N
N
Nagata
N
N
Takahashi
Y
Y
D000818:Animals; D016026:Bone Marrow Transplantation / Q000473:pathology / Q000502:physiology; D002678:Chimera; D004195:Disease Models, Animal; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology* / Q000628:therapy; D006183:H-2 Antigens / Q000032:analysis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006650:Histocompatibility Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011507:Proteinuria; D013154:Spleen / Q000276:immunology
D006183:H-2 Antigens