title: Vasoconstriction induced by inhalation of irritant vapour is associated with appearance of Fos protein in C1 catecholamine neurons in rabbit medulla oblongata.
abstract: The medulla oblongata was examined with Fos and tyrosine hydroxylase (TH) immunohistochemistry after 2 h of intermittent nasopharyngeal stimulation with formaldehyde vapour in the conscious rabbit. The stimulation caused apnoea, bradycardia and a rise in blood pressure known to be associated with vigorous vasoconstriction. Fos-positive neurons occurred in the spinal trigeminal nucleus, the nucleus tractus solitarius, the raphe nuclei and the ventrolateral medulla. In the rostral ventrolateral medulla, 68% of the Fos-positive neurons were TH-positive C1 cells. Our data indicate that nasopharyngeally-evoked peripheral vasoconstriction is associated with activation of C1 neurons.
authors.affiliation: Department of Medicine, Flinders University, Bedford Park, Australia.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Gieroba
authors.forename: Y H
authors.initials: YH
authors.lastname: Yu
authors.forename: W W
authors.initials: WW
authors.lastname: Blessing
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D005557:Formaldehyde / Q000008:administration & dosage / Q000494:pharmacology; D007509:Irritants / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D011817:Rabbits; D011903:Raphe Nuclei / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D017552:Solitary Nucleus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D012668:Trigeminal Ganglion / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D002395:Catecholamines; D007509:Irritants; D016760:Proto-Oncogene Proteins c-fos; D005557:Formaldehyde; D014446:Tyrosine 3-Monooxygenase