Blood pressure, coronary artery disease, and glycaemic control in type 2 diabetes mellitus: relation to apolipoprotein-CIII gene polymorphism.
The apolipoprotein CIII allele S2 is associated with hypertriglyceridaemia and myocardial infarction. 15 subjects with type 2 diabetes mellitus and the S2 allele had significantly greater systolic blood pressure than 48 without this allele (mean 142 [SD10]) vs 129 [14] mmHg), despite being on antihypertensives more frequently. S2 patients showed better glycaemic control (glycated haemoglobin [HbA1C] 8.4 [2.0] vs 9.9 [2.0]%). Stepwise multiple regression indicated S2 as an independent predictor of both blood pressure and HbA1C. These findings suggest mechanisms for relations between glucose and triglyceride metabolism and blood pressure.
Taş
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Department of Pathology, Kuwait University Faculty of Medicine.
Abdella
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NA
D000328:Adult; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D003327:Coronary Disease / Q000150:complications / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; D008055:Lipids