In vitro studies on the metabolism of antipyrine in the pig and rat: with special reference to veterinary medicine licensing.
Preparation of product licence applications for veterinary medicines requires metabolic studies in the target species. This experimental procedure uses animals and is costly. In the present report of preliminary studies it is demonstrated that pig liver homogenates prepared from abattoir material and homogenates of rat liver show the interspecies metabolic differences that would be expected in vivo. The results therefore support the use of abattoir-derived liver homogenates in preliminary studies to investigate target species metabolism in veterinary drug development.
Sainz-Pardo Clares
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LA
Department of Pharmacology, Veterinary Faculty, University of Extremadura, Caceres, Spain.
Shaw
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IC
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D066298:In Vitro Techniques; D008004:Licensure; D008099:Liver / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D013552:Swine; D014730:Veterinary Medicine
D000983:Antipyrine