Sequence of a putative transporter from rabbit kidney related to the Na+/glucose cotransporter gene family.
A 2 kb cDNA, RK-D, was isolated from a rabbit renal library by hybridization with the Na+/glucose cotransporter (SGLT1) cDNA. The mRNA for RK-D is also approximately 2 kb and is found predominantly in kidney. The RK-D cDNA encodes a protein of 597 amino acids related in sequence to the SGLT family of sodium-coupled transporters, all of which are related to the Na+/glucose cotransporter, SGLT1. Because of the high sequence similarity and conservation of 'signature' family features, it is very likely that RK-D encodes a Na(+)-dependent cotransporter.
Pajor
A M
AM
Department of Physiology, University of Arizona, College of Medicine, Tucson 85724.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000302:isolation & purification; D007668:Kidney / Q000378:metabolism*; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000737:chemistry / Q000235:genetics*; D017433:Protein Structure, Secondary; D012333:RNA, Messenger / Q000032:analysis; D011817:Rabbits
D018076:DNA, Complementary; D009004:Monosaccharide Transport Proteins; D012333:RNA, Messenger