title: Telomere reduction of specific chromosome translocation in acute myelocytic leukemia.
abstract: The length of telomere restriction fragments (TRF) was studied by Southern blotting in 42 patients with acute myelocytic leukemia (AML) including 15 patients with 8;21 translocation, 8 with 15;17 translocation and 19 with a normal karyotype. The TRF length of leukemic cells with a normal karyotype and with 8;21 or 15;17 translocation showed significant reduction compared to that of lymphocytes from normal individuals (P < 0.05). In addition, there was a statistically significant difference in TRF length between leukemic cells with a normal karyotype and 8;21 translocation (P < 0.05). Therefore, the significant difference of telomere reduction in 8;21 translocation may be an important factor in the leukemogenic process.
authors.affiliation: Department of Hematology, Hiroshima University.
authors.forename: K
authors.initials: K
authors.lastname: Takauchi
authors.forename: S
authors.initials: S
authors.lastname: Tashiro
authors.forename: M
authors.initials: M
authors.lastname: Ohtaki
authors.forename: N
authors.initials: N
authors.lastname: Kamada
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D002471:Cell Transformation, Neoplastic; D002648:Child; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012044:Regression Analysis; D012091:Repetitive Sequences, Nucleic Acid; D016615:Telomere / Q000473:pathology*; D014178:Translocation, Genetic