title: [Dyslipidemia in herpetic infection].
abstract: Herpes ophthalmicus (HO) patients were examined for lipid spectrum of the serum. The tests revealed dyslipidemia (DLE) with a distinctive rise in the levels of total cholesterol (CS), alpha-CS and beta-CS. The severity of the lipidemic shifts correlated with that of the infection. DLE was more marked in recurrent HO. Clinical evidence was consistent with experimental findings. In rabbit models, herpetic keratoconjunctivitis was characterized by pronounced lipidemic alterations correctable with antiherpetic drug furavir. The results are discussed in terms of herpetic infection pathogenesis and its role in the development of atherosclerosis.
authors.forename: T V
authors.initials: TV
authors.lastname: Amvros'eva
authors.forename: V I
authors.initials: VI
authors.lastname: Votiakov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Chekina
authors.forename: O T
authors.initials: OT
authors.lastname: Andreeva
authors.forename: M P
authors.initials: MP
authors.lastname: Samarina
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D016849:Keratitis, Herpetic / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D007637:Keratoconjunctivitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008297:Male; D011817:Rabbits
chemical_list: D000998:Antiviral Agents; D008055:Lipids
vernacular_title: Dislipidemiia pri gerpeticheskoĭ infektsii.