Glutamine synthesis is a regulatory signal controlling glucose catabolism in Saccharomyces cerevisiae.
The effect of glutamine biosynthesis and degradation on glucose catabolism in Saccharomyces cerevisiae was studied. A wild-type strain and mutants altered in glutamine biosynthesis and degradation were analyzed. Cells having low levels of glutamine synthetase activity showed high ATP/ADP ratios and a diminished rate of glucose metabolism. It is proposed that glutamine biosynthesis plays a role in the regulation of glucose catabolism.
Flores-Samaniego
B
B
Departamento de Microbiología, Universidad Nacional Autónoma de México, D.F., Mexico.
Olivera
H
H
González
A
A
D000244:Adenosine Diphosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D002245:Carbon Dioxide / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005974:Glutamate-Ammonia Ligase / Q000032:analysis; D005973:Glutamine / Q000096:biosynthesis*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D015398:Signal Transduction
D005973:Glutamine; D002245:Carbon Dioxide; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D005974:Glutamate-Ammonia Ligase; D005947:Glucose