title: The spectrum of disease associated with a positive ANCA.
abstract: This is a retrospective analysis of all patients with a raised titre of ANCA in a single centre over a two-year period. Sixty-five patients were identified and clinical data is presented for 58 of these-34 male and 24 female. The median age is 56 years (13-83). Fourteen patients had Wegener's granulomatosis, 14 microscopic polyarteritis nodosa and 30 had other diagnoses. The patients with unexpectedly positive results are discussed in detail. This study confirms the sensitivity of ANCA in Wegener's granulomatosis and microscopic polyarteritis nodosa but suggests that the test is not as specific as initially claimed.
authors.affiliation: Centre for Rheumatic Diseases, Glasgow Royal Infirmary.
authors.forename: E A
authors.initials: EA
authors.lastname: Murphy
authors.forename: J G
authors.initials: JG
authors.lastname: Fox
authors.forename: I
authors.initials: I
authors.lastname: Galbraith
authors.forename: R
authors.initials: R
authors.lastname: Madhok
authors.forename: J M
authors.initials: JM
authors.lastname: Jones
authors.forename: H A
authors.initials: HA
authors.lastname: Capell
mesh_terms: D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000276:immunology*; D012189:Retrospective Studies; D014657:Vasculitis / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies