A comparison of digoxin concentration--time curves before and after open-heart surgery.
The effects of open heart surgery on serum digoxin concentration--time curves were investigated in 10 cardiac patients receiving 0.25 mg/day digoxin. Blood samples were obtained from the patients immediately before and 1, 2, 3, 5, 8, 16 and 24 h after digoxin administration, both before open-heart surgery and 7 days after surgery. Serum digoxin concentrations, determined by fluorescence polarization immuno-assay, significantly (P < 0.05) increased after surgery, as did the maximum serum concentrations and the areas under the concentration-time curves. After surgery there was a significant increase in the serum gamma-glutamyl transferase concentration and a significant reduction in the total protein concentration. A reduction of digoxin dose may be appropriate for patients who have undergone open-heart surgery.
Acikel
U
U
Department of Cardiothoracic Surgery, Faculty of Medicine, University of Dokuz Eylul, Izmir, Turkey.
Guven
H
H
Apaydin
S
S
Silistreli
E
E
Gidener
S
S
Catalyurek
H
H
Oto
O
O
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D005454:Fluorescence Polarization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood
D001798:Blood Proteins; D004077:Digoxin; D005723:gamma-Glutamyltransferase