Detection and identification of famprofazone and its metabolite in human urine.
Detection and identification of famprofazone and its metabolite, p-hydroxydesmethylfamprofazone, were described. The identity of the new metabolite was confirmed by comparing its mass spectrum and gas chromatographic retention time with that of the synthetic standard and its derivatives. Unchanged famprofazone was detected up to 6 h and the metabolite was detected up to 32 h in human urine after administration of famprofazone. The sum of the two compounds excreted in urine was ca. 1.5% of the dose.
Shin
H S
HS
Korea Institute of Science and Technology, Doping Control Center, Seoul.
Park
J S
JS
Park
P B
PB
Yun
S J
SJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008694:Methamphetamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000652:urine; D015394:Molecular Structure; D011720:Pyrazoles / Q000008:administration & dosage / Q000652:urine*; D047069:Pyrazolones
C092648:4-hydroxydesmethylfamprofazone; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D047069:Pyrazolones; D008694:Methamphetamine; C076013:famprofazone