title: Poly(ADP-ribose): historical perspective.
abstract: The early historical background of the discovery of poly(ADP-ribose) and the following development of science on poly(ADP-ribose) are reviewed. Fundamental knowledge on the natures of poly(ADP-ribose), poly(ADP-ribose) polymerase and enzymes degrading poly(ADP-ribose) are summarized with brief description on the methodology for their purification and characterization. Future prospect of research on biological significance of poly(ADP-ribose) has also been discussed briefly.
authors.affiliation: National Cancer Center, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
authors.forename: M
authors.initials: M
authors.lastname: Miwa
mesh_terms: D049673:History, 20th Century; D015394:Molecular Structure; D011064:Poly Adenosine Diphosphate Ribose / Q000737:chemistry / Q000266:history*
chemical_list: D011064:Poly Adenosine Diphosphate Ribose