Vitamin C in CC14 hepatotoxicity--a preliminary report.
1. The hepatotoxic effect of CC14 was studied in the rat by using 3 well established liver function tests (plasma glucose, bilirubin and proteins) as indices of hepatic integrity. 2. The protective effect of vitamin C against this hepatotoxicity was also investigated. 3. CC14 (8 ml kg-1 body weight) caused a decrease in the levels of plasma conjugated bilirubin, glucose and protein. 4. Vitamin C (2 g kg-1 body weight) prevented liver damage induced by CC14. The possible mechanisms of protection are highlighted.
Ademuyiwa
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Department of Biochemistry, College of Health Sciences, Ogun State University, Ago-Iwoye, Nigeria.
Adesanya
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O
Ajuwon
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OR
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D051381:Rats
D001786:Blood Glucose; D001798:Blood Proteins; D002251:Carbon Tetrachloride; D001205:Ascorbic Acid; D001663:Bilirubin