Expression of nuclear hormone receptors within the rat hippocampus: identification of novel orphan receptors.
Within the hippocampus, stimulus-transcriptional coupling plays an important role in post-seizure neuronal adaptation, post-ischemic cell death and the induction of long-term potentiation. To identify additional mediators of hippocampal transcriptional responses a targeted approach was developed and used to characterize the spectrum of nuclear hormone receptors expressed within this brain region. cDNAs encoding the DNA-binding domains of six different members of the nuclear hormone receptor superfamily were isolated. A majority were identical or closely related to receptors known to be expressed within the hippocampus. Two additional isolates, HZF-2 and HZF-3, encode the DNA-binding domain of novel members of the nuclear hormone receptor superfamily.
Peña de Ortiz
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Department of Environmental Health, University of Cincinnati College of Medicine, OH 45267-0056.
Cannon
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MM
Jamieson
G A
GA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000378:metabolism*; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000378:metabolism*; D008024:Ligands; D008297:Male; D008969:Molecular Sequence Data; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics; D011965:Receptors, Glucocorticoid / Q000737:chemistry / Q000145:classification; D017475:Receptors, Nerve Growth Factor / Q000737:chemistry / Q000145:classification; D011988:Receptors, Thyroid Hormone / Q000737:chemistry / Q000145:classification; D016415:Sequence Alignment; D017385:Sequence Homology; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D014158:Transcription, Genetic; D016335:Zinc Fingers / Q000235:genetics
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D008024:Ligands; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D011965:Receptors, Glucocorticoid; D017475:Receptors, Nerve Growth Factor; D011988:Receptors, Thyroid Hormone; D014157:Transcription Factors; D011061:Poly A