title: [Cervicofacial involvement of primary cutaneous neuroendocrine carcinomas or Merkel cell tumors: therapeutic considerations].
abstract: Seven cases of primary skin neuroendocrine carcinoma or Merkel cell tumours with cervico-facial localization are reported. The poor prognosis of these tumours is essentially due to the potential for local recurrence and the frequency of locoregional and visceral metastasis. Surgical treatment is required but rarely sufficient to control the disease. Complementary radiotherapy, when performed early, can reduce the rate of locoregional recurrence. Lymph node resection is important to determine prognosis but has not been proven to improve outcome. In addition, parotid metastasis appears to result from blood stream dissemination and has a very poor prognosis. Exclusive radiotherapy may be discussed in such cases.
authors.affiliation: Service de Chirurgie Plastique, Reconstructrice et Esthétique, Hôpital Trousseau, Tours.
authors.forename: S
authors.initials: S
authors.lastname: de Mortillet
authors.forename: B
authors.initials: B
authors.lastname: Laurent
authors.forename: E
authors.initials: E
authors.lastname: Fassio
authors.forename: F
authors.initials: F
authors.lastname: Zimmann
authors.forename: B
authors.initials: B
authors.lastname: Bonin
authors.forename: J
authors.initials: J
authors.lastname: Brie
authors.forename: D
authors.initials: D
authors.lastname: Goga
authors.forename: G
authors.initials: G
authors.lastname: Ballon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D005153:Facial Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010307:Parotid Neoplasms / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome
vernacular_title: Localisations cervico-faciales des carcinomes neuroendocrines cutanés primaires ou tumeurs à cellules de Merkel: considérations thérapeutiques.