HIV-1 antibody serum negativity with urine positivity.
7 individuals who were negative for HIV-1 antibody in a licensed serum enzyme immunoassay (EIA) were positive in a urine EIA and western blot (WB). Follow-up in individuals by use of a cell-mediated immune response showed 1 positive and 1 negative for HIV-1 peptide reactivity. In a second study, 4 out of 5 subjects positive by urine EIA and indeterminate or negative by serum WB were HIV-1 peptide positive in the cell-mediated immune test. Comparison of cell-mediated responses with urine antibody responses may help to resolve discrepant HIV-1 results.
Urnovitz
H B
HB
Calypte Biomedical Corporation, Berkeley, CA 94710.
Clerici
M
M
Shearer
G M
GM
Gottfried
T D
TD
Robison
D J
DJ
Lutwick
L I
LI
Montagnier
L
L
Landers
D V
DV
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D005260:Female; D015483:HIV Antibodies / Q000652:urine*; D018023:HIV Seronegativity; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged
D015483:HIV Antibodies