title: Nonfunctioning islet cell carcinoma of the pancreas.
abstract: BACKGROUND
  Nonfunctioning islet cell carcinoma of the pancreas has a variable and often indolent natural history, which has resulted in a wide range of treatment recommendations. To more clearly define the natural history and appropriate treatment of this disease, we reviewed our institutional experience over the last 39 years.
  
  
  METHODS
  The records of all patients confirmed to have a nonfunctioning islet cell carcinoma of the pancreas were retrospectively reviewed. Kaplan-Meier life tables were constructed and log-rank comparisons were performed.
  
  
  RESULTS
  The 73 patients studied had an overall 5-year actuarial survival rate of 50%. Patients with localized disease at presentation (n = 39) had a significantly higher survival rate (p = 0.03) compared with patients with metastatic disease (n = 34). The 19 patients who underwent a potentially curative resection of the primary tumor had a significantly higher survival rate (p = 0.03) compared with the 20 patients with locally advanced, unresectable, nonmetastatic disease. Nine of these 20 patients died of complications of the primary tumor. In contrast, only 2 of 22 cancer-related deaths in the 34 patients with metastatic disease at diagnosis were due to the primary tumor.
  
  
  CONCLUSIONS
  (1) Surgical resection should be performed in patients with resectable nonmetastatic disease. (2) Resection of the primary tumor in the presence of metastatic disease is rarely indicated. (3) Innovative treatment strategies are needed for patients with locally advanced, unresectable, nonmetastatic tumors of the pancreatic head.
authors.affiliation: Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: D B
authors.initials: DB
authors.lastname: Evans
authors.forename: J M
authors.initials: JM
authors.lastname: Skibber
authors.forename: J E
authors.initials: JE
authors.lastname: Lee
authors.forename: K R
authors.initials: KR
authors.lastname: Cleary
authors.forename: J A
authors.initials: JA
authors.lastname: Ajani
authors.forename: R F
authors.initials: RF
authors.lastname: Gagel
authors.forename: R V
authors.initials: RV
authors.lastname: Sellin
authors.forename: C J
authors.initials: CJ
authors.lastname: Fenoglio
authors.forename: R C
authors.initials: RC
authors.lastname: Merrell
authors.forename: R C
authors.initials: RC
authors.lastname: Hickey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018273:Carcinoma, Islet Cell / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D011183:Postoperative Complications; D012189:Retrospective Studies; D016019:Survival Analysis