title: Biological evaluation of compounds with -NCS- group or derived from thiazole and imidazole. Activity on prostaglandin synthetase complex.
abstract: The effects of compounds with activity against thyroid peroxidase were tested on the activity of hydroperoxidase and cyclo-oxygenase of the prostaglandin synthetase complex in-vitro. Active compounds were found to inhibit the peroxidase, and the cyclo-oxygenase function. These compounds were also found to have anti-inflammatory activity as demonstrated by the reduction of carrageenan-induced oedema of the hind paw of the rat. Indomethacin and non-steroidal anti-inflammatory drugs tested under the same conditions were shown to have activity towards the cyclo-oxygenase rather than the peroxidase function of the prostaglandin synthetase complex. A common feature of the active compounds was the presence of an -NCS- linkage or free -SH group.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Limoges, France.
authors.forename: T
authors.initials: T
authors.lastname: Moulard
authors.forename: J F
authors.initials: JF
authors.lastname: Lagorce
authors.forename: J C
authors.initials: JC
authors.lastname: Thomas
authors.forename: C
authors.initials: C
authors.lastname: Raby
mesh_terms: D000818:Animals; D002351:Carrageenan; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D010544:Peroxidases / Q000037:antagonists & inhibitors; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D016861:Cyclooxygenase Inhibitors; D007093:Imidazoles; D013844:Thiazoles; D002351:Carrageenan; D010544:Peroxidases; D011451:Prostaglandin-Endoperoxide Synthases