CD4+ T-cell receptor V beta usage during the immune response to Schistosoma mansoni.
T-cell receptor V beta usage by CD4+ cells during the immune response of C57BL/6J mice to Schistosoma mansoni was examined. During acute infection, the distribution of splenic CD4+ cells utilizing V beta s 3, 5, 6, 7, 8.1/8.2, 9, and 11 was not significantly different from that in uninfected mice. Preferential V beta usage or deletion was not detected when either the primary or the memory immune response to parasite eggs was examined.
Vella
A T
AT
Department of Microbiology, Immunology and Parasitology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6401.
Pearce
E J
EJ
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D018089:Superantigens
D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens