Pre-excitation syndrome in Leber's hereditary optic neuropathy.
Pre-excitation syndrome is common in families with Leber's hereditary optic neuropathy (LHON). 24 Finnish families with LHON were screened for the 11778 and the 3460 mitochondrial DNA mutations. 5 of 30 individuals with LHON and the 11778 mutation had the Wolff-Parkinson-White pre-excitation syndrome. None of 10 with the 3460 mutation or of 11 with "other" mutations had this syndrome. Overall, 5 of 51 LHON patients and 9 of 112 symptom-free maternal relatives had Wolff-Parkinson-White syndrome (9%). In paternal relatives, the frequency was 1.6%. Mitochondrial DNA causal for LHON may contribute to pre-excitation syndrome.
Nikoskelainen
E K
EK
Department of Ophthalmology, University of Turku, Finland.
Savontaus
M L
ML
Huoponen
K
K
Antila
K
K
Hartiala
J
J
D004272:DNA, Mitochondrial / Q000235:genetics* / Q000302:isolation & purification; D004562:Electrocardiography; D005260:Female; D005387:Finland; D006801:Humans; D008297:Male; D015418:Optic Atrophies, Hereditary / Q000150:complications / Q000235:genetics*; D017354:Point Mutation; D012737:Sex Factors; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications / Q000235:genetics*
D004272:DNA, Mitochondrial