Flavanones with potent antibacterial activity against methicillin-resistant Staphylococcus aureus.
With the therapeutic concept of using the defensive ability of plants against microbial infections, phytoalexin, an antimicrobial phytochemical was studied for its ability to inhibit the growth of methicillin-resistant Staphylococcus aureus (MRSA). Extracts from Sophora exigua (Leguminosae) were fractionated by serial chromatography and the anti-MRSA activity of each fraction was determined by the agar-plate method. Among the active isolates, 5,7,2',6'-tetrahydroxy-6-isoprenyl-8-lavandulyl-4'-methox yflavanone (exiguaflavanone D) completely inhibited the growth of all the MRSA strains examined at the concentration of 1.56-6.25 micrograms mL-1, and 5, 2',6'-trihydroxy-8-lavandulyl-7-methoxy-flavanone (exiguaflavanone B) inhibited at a concentration of 50 micrograms mL-1. This former compound is expected to be a phytotherapeutic agent for MRSA infections as an alternative to conventional antibiotics with unwanted side-effects or the appearance of antibiotic-resistant bacteria.
Iinuma
M
M
Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
Tsuchiya
H
H
Sato
M
M
Yokoyama
J
J
Ohyama
M
M
Ohkawa
Y
Y
Tanaka
T
T
Fujiwara
S
S
Fujii
T
T
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D044950:Flavanones; D005419:Flavonoids; C092613:exiguaflavanone D