title: [The effect of pharmaceutic aids on gidazepam biotransformation and bioavailability].
abstract: When gidazepam was administered to rats in combination with 4% solutions of Tween 80 or polyvinylpyrrolidone, its bioavailability was higher than its combination with 4% polyethylene glycol 400 solution, as shown by high performance liquid chromatography. Increasing the quantities of these high-molecular compounds in gidazepam solutions was demonstrated to enhance gidazepam dealkylation in the animals after oral administration.
authors.forename: S G
authors.initials: SG
authors.lastname: Otabekova
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: S M
authors.initials: SM
authors.lastname: Vyrovshchikova
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000032:analysis / Q000493:pharmacokinetics*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000032:analysis / Q000493:pharmacokinetics*; D001682:Biological Availability; D001711:Biotransformation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003640:Dealkylation; D008297:Male; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D051381:Rats; D012996:Solutions
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D010592:Pharmaceutic Aids; D012996:Solutions; D001569:Benzodiazepines; C077010:gidazepam
vernacular_title: Vliianie vspomogatel'nykh veshchestv na biotransformatsiiu i biodostupnost' gidazepama.