Variations of the cellular antigens CD4 and CD8 in pollinic patients during the spring.
In order to study the possible variations of CD4 and CD8 antigens in pollinic patients, we have studied 25 individuals (11 rhinoconjunctivitis and 14 rhinoconjunctivitis-asthma) before (T0), in the middle (T1) and after the spring (T2). The number of receptors per cell of CD4 start from values in T0, decrease in T1 and increase at the end of the spring (p < 0.00001), which could represent a mechanism to limit the clonal response to an antigen. An increase in the CD4/CD8 bright ratio could be indicate a higher helper mechanism in T1 with respect to T0 and T2 (p < 0.01). The opposite meaning is to given to the increase of CD8bright receptors in the asthmatic patients, and not only in those who suffer only from a rhinopathy (the only difference between the two groups of patients) during T2 over the T1 (p < 0.00001). The greater number of lymphocytes CD8 dim + during T1 with respect to T2 (p < 0.009) and the increase in the number of receptors of such cells during T1 with respect to T2 (p < 0.00001) suggests a possible intervention of these cells in the regulation of the response of the B and T lymphocytes. Of the two soluble factors CD4 (sCD4) and CD8 (sCD8), only the sCD4 increases during T1 (p < 0.0001) in an inverse manner as occurs with CD4 cell receptors, while the sCD8 remains unchanged during the three periods.(ABSTRACT TRUNCATED AT 250 WORDS)
Monteseirín
J
J
Servicio de Inmunología y Alergia, Hospital Universitario Virgen Macarena, Cátedra de Patología General, Sevilla.
Guardia
P
P
Delgado
J
J
Llamas
E
E
Palma
J
J
Conde
J
J
D001249:Asthma / Q000097:blood / Q000150:complications / Q000276:immunology*; D015704:CD4 Antigens / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis*; D003233:Conjunctivitis, Allergic / Q000097:blood / Q000150:complications / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D007958:Leukocyte Count; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000150:complications / Q000276:immunology*; D012621:Seasons; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D015704:CD4 Antigens; D016827:CD8 Antigens