Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast.
Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.
Bellamy
C O
CO
Department of Pathology, University Medical School, Edinburgh, UK.
Harrison
D J
DJ
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D002278:Carcinoma in Situ / Q000201:enzymology* / Q000473:pathology / Q000556:secondary; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology* / Q000473:pathology / Q000556:secondary; D066246:ErbB Receptors / Q000032:analysis / Q000235:genetics; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression / Q000235:genetics; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis*; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases
D066246:ErbB Receptors; D005982:Glutathione Transferase; D007527:Isoenzymes; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases