Effect of Helicobacter pylori eradication on antral gastrin- and somatostatin-immunoreactive cell density and gastrin and somatostatin concentrations.
The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of Helicobacter pylori. After H. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral D-cell density (p = 0.01) increased significantly. Conversely, although the number of G-cells was unchanged, antral (p = 0.0002) and serum (p = 0.001) gastrin contents decreased significantly. The number of oxyntic D-cells did not change significantly. These results strongly suggest that the hypergastrinaemia observed in H. pylori-positive patients may be due to a deficiency in antral somatostatin, which normally inhibits the synthesis and release of gastrin.
Queiroz
D M
DM
Laboratory of Research in Bacteriology, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Mendes
E N
EN
Rocha
G A
GA
Moura
S B
SB
Resende
L M
LM
Barbosa
A J
AJ
Coelho
L G
LG
Passos
M C
MC
Castro
L P
LP
Oliveira
C A
CA
D000328:Adult; D001706:Biopsy; D002452:Cell Count; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D005755:Gastrins / Q000378:metabolism*; D005756:Gastritis / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology; D005773:Gastroscopy; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011706:Pyloric Antrum / Q000378:metabolism* / Q000473:pathology; D013004:Somatostatin / Q000378:metabolism*; D013997:Time Factors
D005755:Gastrins; D013004:Somatostatin