title: The action of the herbicide paraquat on somatic and germ cells of mice.
abstract: The genotoxic potential of paraquat was evaluated in mouse somatic (bone marrow) and germ (spermatozoa) cells. Two exposure schedules were conducted: single and multiple treatment. Only for multiple treatment was an increased frequency of chromosomal aberrations observed. In germ cells, paraquat induced an increase of sperm-shape abnormalities when the animals were treated at three stages of cell development: spermatozoa, spermatid and preleptotene spermatogonial cells. These toxicogenetic effects might be attributed to the ability of paraquat to generate oxygen free radicals.
authors.affiliation: Laboratory of Toxicology and Genetic Toxicology, School of Veterinary Science, Federal University of Bahia, Salvador-BA, Brazil.
authors.forename: A C
authors.initials: AC
authors.lastname: Rios
authors.forename: D M
authors.initials: DM
authors.lastname: Salvadori
authors.forename: S V
authors.initials: SV
authors.lastname: Oliveira
authors.forename: L R
authors.initials: LR
authors.lastname: Ribeiro
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010269:Paraquat / Q000633:toxicity*; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D009153:Mutagens; D010269:Paraquat