Perirhinal cortex lesions in rats disrupt performance in a spatial DNMS task.
Rats with bilateral electrolytic lesions of the perirhinal cortex and sham operated control rats were tested in a spatially guided, delayed non match to sample task. Although perirhinal lesioned animals showed no deficit in acquisition of the task, a performance deficit was observed across longer delay intervals. These results indicate that the perirhinal cortex is a critical component of the network subserving working or declarative memory in the rat.
Wiig
K A
KA
Department of Psychology, University of Otago, Dunedin, New Zealand.
Bilkey
D K
DK
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D018728:Entorhinal Cortex / Q000502:physiology; D005260:Female; D018782:Maze Learning / Q000502:physiology*; D008568:Memory; D051381:Rats; D017207:Rats, Sprague-Dawley; D013037:Spatial Behavior / Q000502:physiology; D013997:Time Factors