title: Cloning of chicken hsp90 beta: the only vertebrate hsp90 insensitive to heat shock.
abstract: The cloning of chicken hsp90 beta, reported here, supports the hypothesis that the hsp90 alpha and beta genes are the result of a gene duplication event that occurred at the time of the emergence of vertebrates. Avian hsp90 beta mRNA is not inducible by thermal stress contrary to the mouse and human hsp90 alpha and beta mRNAs. Moreover, hsp90 beta mRNA level is not increased by mitogenic stimuli, like serum or insulin, which induce hsp90 alpha mRNA. Different functions and regulations of hsp90 alpha and beta will be probably more easily understood in the avian species than in higher vertebrates.
authors.affiliation: INSERM U33, Lab. Hormones, Le Kremlin-Bicêtre, France.
authors.forename: X
authors.initials: X
authors.lastname: Meng
authors.forename: V
authors.initials: V
authors.lastname: Jérôme
authors.forename: J
authors.initials: J
authors.lastname: Devin
authors.forename: E E
authors.initials: EE
authors.lastname: Baulieu
authors.forename: M G
authors.initials: MG
authors.lastname: Catelli
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001769:Blood; D015152:Blotting, Northern; D015139:Blotting, Southern; D002645:Chickens / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry / Q000235:genetics; D015342:DNA Probes; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics*; D006358:Hot Temperature; D007328:Insulin / Q000494:pharmacology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: D015342:DNA Probes; D006360:Heat-Shock Proteins; D007328:Insulin; D012333:RNA, Messenger; D004247:DNA