[Intensity of glycolysis and activity of energy metabolism enzymes in rat brain after multiple exposures to hypoglycemic doses of insulin].
Changes in the rates of glycolysis, glycogenolysis, activities of pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, serum glutamic pyruvic and oxaloacetic transaminases in the brain hemispheres and stem of rats exposed to 5-7 hypoglycemic comas were studied. No noticeable changes were detected in glycolysis intensity or activities of Krebs' cycle enzymes in the large hemispheres. The intensity of glycogenolysis and activities of transaminases in the brain stem reduce on day 2 of repair period after the last hypoglycemic coma. The detected changes result from multiple exposures of the brain to hypoglycemia and may be important in the development of posthypoglycemic encephalopathy.
Telushkin
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Potapov
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D000410:Alanine Transaminase / Q000187:drug effects; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002952:Citric Acid Cycle / Q000187:drug effects; D004334:Drug Administration Schedule; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats
D007328:Insulin; D006003:Glycogen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Intensivnost' glikoliza i aktivnost' fermentov énergeticheskogo obmena v mozge krys pri monogokratnom vozdeĭstvii gipoglikemicheskikh doz insulina.