Postnatal decrease of acetate concentration in rat cerebellum.
We examined the evolution of 1H-NMR detectable metabolites in rat cerebellum from the postnatal day 1-25, a period associated with intense metabolic changes as well as physiological and morphological modifications. The unexpected result reported here is the existence of a high concentration of acetate in neonatal rat cerebellum, progressively decreasing with age and maturation. In contrast, the cerebellum content of various metabolites such as N-acetyl-L-aspartate (NAA), glutamate, and aspartate increases from the first day onward.
Martin
M
M
Institut de Biochimie Cellulaire du CNRS, Université de Bordeaux II, France.
Merle
M
M
Labouesse
J
J
Canioni
P
P
D000085:Acetates / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002531:Cerebellum / Q000254:growth & development / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D017208:Rats, Wistar
D000085:Acetates; D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; C000179:N-acetylaspartate