[Possible involvement of atrial natriuretic factor and vasopressin in antihypertensive mechanism of clonidine in humans].
To appreciate the role of some neuropeptides in the antihypertensive mechanism of clonidine, 17 patients with essential hypertension were given po clonidine 150 micrograms tid for 3 d. Plasma atrial natriuretic factor (ANF), vasopressin (Vas), and dynorphin A (Dyn A) were measured by radioimmunoassay. After the treatment, mean blood pressure (MBP), heart rate and 24 h urine norepinephrine, epinephrine were decreased, but no change was found in plasma Dyn A. The magnitudes of increased ANF and decreased Vas were correlated with the decreased MBP (r = -0.57 and 0.53, respectively, P < 0.05). These results suggest that both ANF and Vas are involved in the antihypertensive mechanism of clonidine.
He
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First Affliated Hospital of Fujian Medical College, Hypertension Division, Fuzhou, China.
Chen
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DG
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology / Q000627:therapeutic use*; D004399:Dynorphins / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins; D004399:Dynorphins; D009320:Atrial Natriuretic Factor; D003000:Clonidine