title: Gastroenteropancreatic neuroendocrine tumours contain a common set of synaptic vesicle proteins and amino acid neurotransmitters.
abstract: Human neuroendocrine tumours of the gastroenteropancreatic system contain major integral membrane proteins of small synaptic vesicles of neurons, together with characteristic membrane polypeptides of large dense-core vesicles of neurons and neuroendocrine cells. The membrane polypeptides characteristic for small synaptic and large dense-core vesicles are detected in pheochromocytomas (n = 6), functional (n = 6) and non-functional (n = 6) foregut, and midgut carcinoids (n = 17). All gastroenteropancreatic tumours contain large amounts of amino acid neurotransmitters, i.e. glycine and glutamate. gamma-Aminobutyric acid, however, is only found in some foregut carcinoids. Thus, neuroendocrine gastroenteropancreatic tumours possess a vesicle type with a content and membrane composition similar to small synaptic vesicles of neurons.
authors.affiliation: Department of Internal Medicine, Universitätsklinikum Steglitz, Free University of Berlin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Ahnert-Hilger
authors.forename: K
authors.initials: K
authors.lastname: Grube
authors.forename: L
authors.initials: L
authors.lastname: Kvols
authors.forename: I
authors.initials: I
authors.lastname: Lee
authors.forename: E
authors.initials: E
authors.lastname: Mönch
authors.forename: E O
authors.initials: EO
authors.lastname: Riecken
authors.forename: L
authors.initials: L
authors.lastname: Schmitt
authors.forename: B
authors.initials: B
authors.lastname: Wiedenmann
mesh_terms: D000818:Animals; D002276:Carcinoid Tumor / Q000737:chemistry*; D005770:Gastrointestinal Neoplasms / Q000737:chemistry; D005971:Glutamates / Q000032:analysis; D005998:Glycine / Q000032:analysis; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis*; D009363:Neoplasm Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis; D018377:Neurotransmitter Agents / Q000032:analysis; D010673:Pheochromocytoma / Q000737:chemistry*; D051381:Rats; D013572:Synaptic Vesicles / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000737:chemistry
chemical_list: D005971:Glutamates; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D005998:Glycine