[Defense mechanisms against bacteria of intracellular development].
Intracellular bacteria are not inhibited by antibodies. Therefore the main mechanisms of resistance against these pathogens are the influx and activation of mononuclear phagocytes by the synergistic interaction of gamma-interferon and tumour necrosis factor. During the early phase of infection, gamma-interferon is produced by IL-12-activated natural killer cells (IL-12 being mainly produced by macrophages). In the later phase of infection acquired immunity is T-cell-mediated and involves the Th1 CD4+ subpopulation. These cells produce gamma-interferon when triggered by antigen. There is a complex network of interactions among cytokines. Some cytokines act synergistically to enhance resistance to infection, yet antagonistic interactions can sometimes occur.
Nauciel
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Laboratoire de Microbiologie, CHU de Paris-Ouest, Garches.
D000818:Animals; D001419:Bacteria / Q000254:growth & development*; D001424:Bacterial Infections / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology / Q000502:physiology*
Mécanismes de défense contre les bactéries à développement intracellulaire.