Protective effect of DS-4574 on gastric mucosal injury induced by acidified ethanol in rats.
We compared the protective effect of DS-4574, a peptidoleukotriene receptor antagonist with mast cell stabilizing action, on rat gastric mucosal injury induced by acidified ethanol to that of LY171883, a selective peptidoleukotriene receptor antagonist. Oral treatment with DS-4574 (1-10 mg/kg) or LY171883 (100 and 300 mg/kg) markedly suppressed this mucosal necrosis. Moreover, DS-4574 (10 mg/kg) significantly inhibited both mucosal edema and degranulation of mucosal mast cells. LY171883 (300 mg/kg) protected only from mucosal edema, but not degranulation of mucosal mast cells. These results suggest that DS-4574 possesses protective actions against gastric injury including the reduction of degranulation of mucosal mast cells, which are different from those of LY171883.
Tabuchi
Y
Y
Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Kawarabayashi
K
K
Komada
T
T
Furuhama
K
K
D000098:Acetophenones / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D012898:Autacoids / Q000037:antagonists & inhibitors; D015550:Cell Degranulation / Q000187:drug effects; D004487:Edema / Q000188:drug therapy; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006863:Hydrogen-Ion Concentration; D020024:Leukotriene Antagonists; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D009336:Necrosis / Q000188:drug therapy; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013777:Tetrazoles / Q000494:pharmacology / Q000627:therapeutic use; D014230:Triazoles / Q000494:pharmacology* / Q000627:therapeutic use
D000098:Acetophenones; D012898:Autacoids; D020024:Leukotriene Antagonists; D011743:Pyrimidines; D013777:Tetrazoles; D014230:Triazoles; C076052:DS 4574; D000431:Ethanol; C044660:LY 171883