Correlation of heat shock protein 70 expression with estrogen receptor levels in invasive human breast cancer.
The authors studied the role of 70-Kd heat shock protein (HSP70) in the progression of breast cancer by examining the correlation between the expression of HSP70 and epidermal growth factor receptor, c-erbB-2, p53, and estrogen receptor in 124 cases of invasive primary human breast cancers. Positivity of an anti-HSP70 monoclonal antibody, C92, was closely associated with the elevation of estrogen receptor (P < .008), whereas it inversely correlated with the expression of p53 (P < .01). In addition, the expression of HSP70 correlated inversely with the expression of epidermal growth factor receptor, although the correlation was not statistically significant (P = .06). These results suggest that the expression of HSP70 plays a role in the progression of human breast cancer.
Takahashi
S
S
Division of Pathology, Sapporo Medical University Hospital, Japan.
Mikami
T
T
Watanabe
Y
Y
Okazaki
M
M
Okazaki
Y
Y
Okazaki
A
A
Sato
T
T
Asaishi
K
K
Hirata
K
K
Narimatsu
E
E
D001943:Breast Neoplasms / Q000737:chemistry*; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D006360:Heat-Shock Proteins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D066246:ErbB Receptors; D006360:Heat-Shock Proteins; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D016159:Tumor Suppressor Protein p53