Spectral analysis of corticomotor evoked potentials in spinal cord injury. Part 1. Acute studies.
A model of graded spinal cord injury using ischaemia has been developed by using balloon occlusion of the abdominal aorta in rabbits. This model has been used to test pharmacological agents thought to provide protection against spinal cord injury based on changes in corticomotor evoked potentials (CMEPs). These highly reproducible signals are percutaneously recorded from the spinal cord in response to cortical stimulation and accurately reflect the degree of residual spinal cord function. The present study focused on the power spectra of CMEPs to clarify alterations in post-injury signals. This added dimension of previously unreported CMEP analysis will augment future applications of the current model.
Simpson
R K
RK
Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030.
Contant
C F
CF
Robertson
C S
CS
Goodman
J C
JC
D000208:Acute Disease; D000818:Animals; D002404:Catheterization; D004195:Disease Models, Animal; D005071:Evoked Potentials / Q000502:physiology; D007511:Ischemia / Q000503:physiopathology; D009044:Motor Cortex / Q000502:physiology*; D011817:Rabbits; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013057:Spectrum Analysis / Q000379:methods; D013118:Spinal Cord Diseases / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000503:physiopathology*