title: Inhibition of adhesion of enterotoxigenic Escherichia coli cells expressing F17 fimbriae to small intestinal mucus and brush-border membranes of young calves.
abstract: Enterotoxigenic Escherichia coli strains expressing F17 fimbriae bind to the intestinal mucosa of young calves. F17 fimbriae recognize receptors present in the mucus layer and the brush-border membranes from duodenum, jejunum and ileum. The adhesion of E. coli F17 can be inhibited by several glycoproteins. Adhesion is also inhibited by pretreatment of mucus and brush-border membranes with sodium metaperiodate. The use of glycoconjugates as potential adhesion-blockers is further discussed.
authors.affiliation: Vrije Universiteit Brussel, Laboratorium Chemie der Proteïnen, Sint-Genesius-Rode, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Sanchez
authors.forename: L
authors.initials: L
authors.lastname: Kanarek
authors.forename: J
authors.initials: J
authors.lastname: Koninkx
authors.forename: H
authors.initials: H
authors.lastname: Hendriks
authors.forename: P
authors.initials: P
authors.lastname: Lintermans
authors.forename: A
authors.initials: A
authors.lastname: Bertels
authors.forename: G
authors.initials: G
authors.lastname: Charlier
authors.forename: E
authors.initials: E
authors.lastname: Van Driessche
mesh_terms: D018830:Adhesins, Escherichia coli; D000818:Animals; D000942:Antigens, Bacterial / Q000096:biosynthesis* / Q000378:metabolism; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis* / Q000378:metabolism; D002417:Cattle; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D004927:Escherichia coli Infections / Q000382:microbiology; D007413:Intestinal Mucosa / Q000382:microbiology*; D007421:Intestine, Small / Q000382:microbiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008871:Microvilli / Q000382:microbiology
chemical_list: D018830:Adhesins, Escherichia coli; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins