[The solubility and bioequivalence of silymarin preparations].
Seven silymarin products (pharmacies only), two of them with two batches each, were analysed for their ingredients, in particular silibinin (CAS 22888-70-6) and tested in vitro for their liberation of active agents. Founded on the results of these tests three products were checked for bioequivalence. Therefore, a typical phase I 3 fold crossover study was performed showing one product (Legalon) to be qualified by an approx. 2 fold higher silibinin availability compared to the two other preparations.
Schulz
H U
HU
LAFAA, Laboratory for Contract Research in Clinical Pharmacology and Biopharmaceutical Analytics GmbHa, Köln.
Schürer
M
M
Krumbiegel
G
G
Wächter
W
W
Weyhenmeyer
R
R
Seidel
G
G
D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D012838:Silymarin / Q000737:chemistry* / Q000493:pharmacokinetics*; D012995:Solubility; D013810:Therapeutic Equivalency
D012838:Silymarin
Untersuchungen zum Freisetzungsverhalten und zur Bioäquivalenz von Silymarin-Präparaten.