Induction of G protein-coupled peptide receptor EBI 1 by human herpesvirus 6 and 7 infection in CD4+ T cells.
EBI 1, a putative lymphocyte-specific G protein-coupled peptide receptor, was induced by human herpesvirus 6 or 7 infection in CD4+ T cells, and its expression increased early after infection and reached a plateau at 48 h. The induction of the EBI 1 gene by human herpesvirus 6 or 7 infection was not mediated by soluble factors but by the virus itself. Deduced from comparisons of the amino acid sequences among members of the G protein-coupled receptor superfamily, these findings suggest that EBI 1 may be a member of the leukocyte chemotactic peptide receptor family.
Hasegawa
H
H
First Department of Internal Medicine, Ehime University School of Medicine, Japan.
Utsunomiya
Y
Y
Yasukawa
M
M
Yanagisawa
K
K
Fujita
S
S
D000595:Amino Acid Sequence; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000382:microbiology*; D002478:Cells, Cultured; D015967:Gene Expression Regulation, Viral; D015654:Herpesvirus 6, Human / Q000502:physiology*; D016199:Herpesvirus 7, Human / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D054400:Receptors, CCR7; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D019707:Receptors, Chemokine; D017386:Sequence Homology, Amino Acid; D014779:Virus Replication
C515370:CCR7 protein, human; D054400:Receptors, CCR7; D011956:Receptors, Cell Surface; D019707:Receptors, Chemokine