title: Metabolites of ebrotidine, a new H2-receptor antagonist, in human urine.
abstract: Ebrotidine is a new H2-receptor antagonist which exhibits a remarkable ability for gastric mucosal protection. A preliminary metabolic pathway for this compound was proposed and the hypothetic metabolites were synthesized. The presence of ebrotidine and its metabolites ebrotidine S-oxide and 4-bromobenzenesulfonamide in human urine has been confirmed by HPLC separation and spectroscopic characterization of the collected fractions by FT-IR and 1H NMR. Ebrotidine S,S-dioxide has been identified by HPLC using diode-array detection.
authors.affiliation: Centro de Investigación Grupo Ferrer, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Rozman
authors.forename: M T
authors.initials: MT
authors.lastname: Galcerán
authors.forename: L
authors.initials: L
authors.lastname: Anglada
authors.forename: C
authors.initials: C
authors.lastname: Albet
mesh_terms: D001557:Benzenesulfonates / Q000493:pharmacokinetics / Q000652:urine*; D001711:Biotransformation; D001969:Bromobenzenes / Q000493:pharmacokinetics / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D006635:Histamine H2 Antagonists / Q000493:pharmacokinetics / Q000652:urine*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000493:pharmacokinetics / Q000652:urine; D013844:Thiazoles / Q000493:pharmacokinetics / Q000652:urine*; D000096926:Benzenesulfonamides
chemical_list: D001557:Benzenesulfonates; D001969:Bromobenzenes; D006635:Histamine H2 Antagonists; D013449:Sulfonamides; D013844:Thiazoles; C086998:ebrotidine S,S-dioxide; C086997:ebrotidine S-oxide; C086996:4-bromobenzenesulfonamide; D000096926:Benzenesulfonamides; C075156:ebrotidine