Facilitation of social learning by treatment with an NMDA receptor antagonist.
A single oral treatment with 0.3 mg/kg of the competitive NMDA receptor blocker CGP 37 849 improved the retention performance of rats in a social memory paradigm. The effect disappeared with increasing doses: at 1 mg/kg a positive trend could still be observed; at 3 mg/kg no effect whatever was detectable.
Lederer
R
R
Pharma Research Department, Ciba Ltd., Basel, Switzerland.
Radeke
E
E
Mondadori
C
C
D015763:2-Amino-5-phosphonovalerate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000819:Animal Communication; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012153:Retention, Psychology / Q000187:drug effects*; D012932:Social Facilitation
C064539:2-amino-4-methyl-5-phosphono-3-pentenoic acid; D015763:2-Amino-5-phosphonovalerate