Quantal properties of S-type glutamatergic synaptic input to the striatal medium spiny neuron from neonate rat.
We investigated the quantal properties of the small glutamatergic EPSPs (S-type EPSPs) in the striatal medium spiny neurons using the whole-cell recording method. Amplitudes of unitary glutamatergic EPSCs displayed a single peak at about 4.7 pA that was unaffected by decreasing external Ca2+. This indicates that afferent fibers contact the medium spiny neuron with only a few, possibly one, release sites which generate no more than one quantum of EPSCs at a time.
Mori
A
A
Department of Physiology, Faculty of Medicine, University of Tokyo, Japan.
Takahashi
T
T
Miyashita
Y
Y
Kasai
H
H
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002118:Calcium / Q000502:physiology; D004558:Electric Stimulation; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000502:physiology; D017072:Neostriatum / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000502:physiology*
D005971:Glutamates; D018698:Glutamic Acid; D002118:Calcium