title: [The current pathogenetic aspects of diarrhea in ulcerative colitis].
abstract: The authors consider different mechanisms participating in progression of diarrhea in ulcerative colitis. The involvement of osmotic component was suggested in view of incomplete hydrolysis of carbohydrates by small intestinal glucoamylase under mono- and bisubstrate digestion, whereas diarrhea secretory component develops in participation of cyclic nucleotides. Motor mechanism is also present in diarrhea as evidenced by high concentrations of blood motilin and changes in intestinal evacuation and motility. Polycomponent dysbioses detected in ulcerative colitis patients may also be essential for pathogenesis of diarrhea. Determination of the leading component in each diarrhea case is thought helpful in valid choice of individual therapeutic policy.
authors.forename: A R
authors.initials: AR
authors.lastname: Zlatkina
authors.forename: E A
authors.initials: EA
authors.lastname: Belousova
authors.forename: A A
authors.initials: AA
authors.lastname: Misautova
authors.forename: T
authors.initials: T
authors.lastname: Peters
authors.forename: K V
authors.initials: KV
authors.lastname: Bezzubik
authors.forename: L I
authors.initials: LI
authors.lastname: Vinnitskiĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications* / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D003967:Diarrhea / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D004063:Digestion; D004064:Digestive System / Q000382:microbiology; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000097:blood; D009712:Nucleotides, Cyclic / Q000378:metabolism; D012007:Rectum / Q000378:metabolism
chemical_list: D009712:Nucleotides, Cyclic; D009037:Motilin
vernacular_title: Sovremennye aspekty patogeneza diarei pri iazvennom kolite.