title: Vaginal prostaglandins for the ripe cervix.
abstract: OBJECTIVE
  To assess the efficacy of vaginal prostaglandin (PGE2) tablets for induction of labor in the presence of a ripe cervix.
  
  
  METHODS
  A randomized controlled trial was performed. Two hundred and nine consecutive women undergoing induction of labor with a Bishop Score > or = 5 were randomly assigned to (a). Study group receiving PGE2 tablets (n = 106) and (b). Control group having artificial rupture of membranes only (n = 103). The duration of labor, oxytocin and analgesia requirements, the mode of delivery, complications and duration of confinement were recorded.
  
  
  RESULTS
  Mean duration of first stage of labor was shorter in parous patients in the study group (194 min v. 319 min), as was the mean induction delivery interval in primigravidas. Oxytocin was used in 75% of primiparas and 40% multiparas in the study group compared with 100% and 80%, respectively, in the controls. Epidural analgesics and instrumental delivery rates were also reduced.
  
  
  CONCLUSIONS
  The use of vaginal PGE2 tablets for induction of labor with a ripe cervix is associated with a shorter first stage of labor and with reduced requirements for oxytocin, analgesia and instrumental delivery.
authors.affiliation: Department of Obstetrics and Gynaecology, University College Hospital, Galway, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Casey
authors.forename: J
authors.initials: J
authors.lastname: Kehoe
authors.forename: M J
authors.initials: MJ
authors.lastname: Mylotte
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D016362:Analgesia, Obstetrical; D002584:Cervix Uteri / Q000502:physiology*; D002585:Cesarean Section / Q000706:statistics & numerical data; D015232:Dinoprostone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007747:Labor Stage, First; D007751:Labor, Induced / Q000379:methods*; D010121:Oxytocin; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D013997:Time Factors
chemical_list: D010121:Oxytocin; D015232:Dinoprostone