Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate.
Interferon-gamma is a T cell secreted cytokine. It has a great number of biological activities, among which is the down regulation of collagen molecules. IFN-gamma acts through cell surface receptors, but also binds to heparan sulfate proteoglycans. In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine.
Lortat-Jacob
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H
Unité de Physiopathologie Cellulaire et Moléculaire des Fibroses Tissulaires-CNRS URA 1459, Institut Pasteur de Lyon, France.
Esterre
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P
Grimaud
J A
JA
D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D005355:Fibrosis / Q000378:metabolism; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D011485:Protein Binding
D006497:Heparan Sulfate; D007371:Interferon-gamma