Constructing confidence intervals for QTL location.
We describe a method for constructing the confidence interval of the QTL location parameter. This method is developed in the local asymptotic framework, leading to a linear model at each position of the putative QTL. The idea is to construct a likelihood ratio test, using statistics whose asymptotic distribution does not depend on the nuisance parameters and in particular on the effect of the QTL. We show theoretical properties of the confidence interval built with this test, and compare it with the classical confidence interval using simulations. We show in particular, that our confidence interval has the correct probability of containing the true map location of the QTL, for almost all QTLs, whereas the classical confidence interval can be very biased for QTLs having small effect.
Mangin
B
B
Institut National de la Recherche Agronomique, Station de Biométrie et d'Intelligence Artificielle, Castanet-Tolosan, France.
Goffinet
B
B
Rebaï
A
A
D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D003198:Computer Simulation; D016001:Confidence Intervals; D005819:Genetic Markers; D016013:Likelihood Functions; D008126:Lod Score
D005819:Genetic Markers