T cell receptor polymorphisms in Caucasians and Polynesians.
The purpose of this study was to find genetic polymorphisms that might be useful in studies of Polynesian-Caucasian racial admixture and Polynesian disease susceptibility. The allele frequencies of six T cell receptor locus RFLP were measured in 73 Caucasians and two Polynesian ethnic groups comprising 86 Maoris and 95 Samoans. The RFLP studied were (locus/enzyme/probe): C alpha/Taq1/Y14, V alpha/Taq1/Y14, C beta/BglII/Y35, C gamma/Pvu II/HGP02, V beta 7/BamHI/V beta 7.4 and V beta 8/Bam HI/V beta 8.1. Racial differences in allele frequency were present with all six RFLP (P < 0.001). The allele frequencies of the V alpha/Taq1/Y14 and the V beta 7/BamHI/7.4 RFLP were similar in the two Polynesian groups, both of which differed from the Caucasians. The 1.4 kb allele of the V alpha/Taq1/Y14 RFLP and the 8.0 kb allele of the V beta 7/BamHI/7.4 RFLP were present in low frequency in both Polynesian groups compared to the Caucasian group, consistent with a gene flow effect. These alleles may be useful in studies of Caucasian-Polynesian racial admixture.
Abbott
W G
WG
Department of Molecular Medicine, Auckland Medical School, New Zealand.
Tan
P L
PL
Skinner
M A
MA
Marbrook
J
J
Peake
J S
JS
Woodfield
D G
DG
Geursen
A
A
D000293:Adolescent; D000328:Adult; D000483:Alleles; D015139:Blotting, Southern; D018076:DNA, Complementary; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D014905:Independent State of Samoa / Q000208:ethnology; D008297:Male; D009520:New Zealand; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics*; D044465:White People / Q000235:genetics*
D018076:DNA, Complementary; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta