[The mechanism of action of permethrin on house dust mites].
The mechanism of permetrin action on two home dust mite species: Dermatophagoides farinae and D. pteronyssinus. Both species turned out to be resistant to permetrin under different conditions of toxicity evaluation. A factor of cuticle permeability was investigated. The impact of monoxygenases and esterases in the permetrin detoxication mechanism was shown. The spectra of esterase complexes of enzymes was examined by means of electrophoresis in PAAG; in addition, the zones of esterase activity were identified with the help of two substrates: 2-NA and ATI. The qualitative differences of the esterase complexes of enzymes of both species were found.
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D004391:Dust; D004655:Emulsions; D004950:Esterases / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity; D008925:Mites / Q000201:enzymology; D009758:Nymph; D010105:Oxygenases / Q000187:drug effects; D026023:Permethrin; D011722:Pyrethrins / Q000633:toxicity
D004391:Dust; D004655:Emulsions; D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin; D010105:Oxygenases; D004950:Esterases
Izuchenie mekhanizma deĭstviia permetrina na kleshcheĭ domashneĭ pyli.