Effect of nicotine on swimming exercise in rats.
In this study, endurance time in swimming exercise was evaluated in rats. Subcutaneous (S.C.) injection of nicotine decreased the endurance time in swimming exercise significantly, in a dose-dependent manner compared to the control group. At the dose of 0.125 mg/kg nicotine, the endurance time in swimming exercise remained unchanged, while at the doses of 0.25 and 0.375 mg/kg, it decreased significantly (p < 0.05 and p < 0.01, respectively). This effect of nicotine was antagonized by pretreatment with hexamethonium 5 mg/kg S.C. These results suggest that nicotine may limit the physical performance.
Temocin
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S
Department of Physiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Erenmemisoglu
A
A
Suer
C
C
Beydagi
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010807:Physical Endurance / Q000187:drug effects / Q000502:physiology; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013550:Swimming / Q000502:physiology
D006584:Hexamethonium Compounds; D018738:Hexamethonium; D009538:Nicotine