Improvement in CD4 lymphocyte count in HIV-Reiter's syndrome after treatment with sulfasalazine.
OBJECTIVE
To describe an observed improvement in CD4 lymphocytes in patients with Reiter's syndrome (RS) and human immunodeficiency virus (HIV) infection, after treatment with sulfasalazine (SFSZ). METHODS . Care series. We analyzed CD4 lymphocyte counts in 4 consecutive patients with RS and HIV disease before and after treatment with SFSZ.


RESULTS
CD4+ lymphocyte counts increased from a mean of 315 +/- 179 before treatment to 542 +/- 231 x 10(6)/l on followup (p < 0.03), in the absence of antiretroviral therapy. The significance of these observations is discussed.


CONCLUSIONS
Treatment of RS with SFSZ in HIV disease appears to be associated with an improvement in CD4 count.
Disla
E
E
Department of Medicine, Cabrini Medical Center, New York, NY 10003.
Rhim
H R
HR
Reddy
A
A
Taranta
A
A
D000328:Adult; D016918:Arthritis, Reactive / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D016516:CD4-CD8 Ratio / Q000187:drug effects; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects*; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012460:Sulfasalazine / Q000627:therapeutic use*; D013997:Time Factors
D012460:Sulfasalazine