Management of injuries caused by Cryptococcus neoformans--contaminated needles.
This report describes four skin-puncture accidents with needles that were heavily contaminated with Cryptococcus neoformans. In one accident, delayed administration of antifungal drugs resulted in a granuloma of the finger. In the other three accidents, no skin infection followed immediate prophylaxis with oral fluconazole. Our experience suggests that early therapy with fluconazole is a reasonable means of managing skin injuries caused by instruments contaminated with viable C. neoformans.
Casadevall
A
A
Department of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, Bronx, New York.
Mukherjee
J
J
Yuan
R
R
Perfect
J
J
D000059:Accidents; D003453:Cryptococcosis / Q000188:drug therapy*; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D016602:Needlestick Injuries / Q000188:drug therapy*
D015725:Fluconazole