title: Trisomy 12 in B-cell chronic lymphocytic leukaemia: an evaluation of 33 patients by direct fluorescence in situ hybridization (FISH).
abstract: An adaptation of the standard fluorescence in situ hybridization (FISH) technique allowing rapid analysis (4 h) has been used to study the prevalence of trisomy 12 in 33 patients with B-CLL, of whom 54% have been shown to have this abnormality. The presence of trisomy 12 has been compared with clinical parameters, and there may be a relationship between the prevalence of trisomy 12 in B-CLL and duration of disease.
authors.affiliation: Department of Haematology, East Birmingham Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Bienz
authors.forename: D L
authors.initials: DL
authors.lastname: Cardy
authors.forename: M J
authors.initials: MJ
authors.lastname: Leyland
authors.forename: M A
authors.initials: MA
authors.lastname: Hultén
mesh_terms: D000328:Adult; D000368:Aged; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008875:Middle Aged; D013997:Time Factors; D014314:Trisomy