title: Basal cell carcinoma of the vulva with lymph node and skin metastasis--report of a case and review of 20 Japanese cases.
abstract: A 79-year-old Japanese woman who had basal cell carcinoma presenting as a large ulcer on her vulva with lymph node and skin metastasis is described. Histological examination revealed that tumor nests with peripheral palisading invaded deeply into the subcutaneous tissue and were accompanied by marked mucinous changes and fibrous reaction. Vascular invasion was also observed. There were inguinal lymph node metastases and two papular skin metastases on her right thigh. The primary tumor and the metastases were excised. The defect was repaired by bilateral gracilis musculo cutaneous flaps and a skin graft. We surveyed the literature and found 20 cases of metastasizing basal cell carcinoma in Japan.
authors.affiliation: Department of Dermatology, Toranomon Hospital, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Mizushima
authors.forename: K
authors.initials: K
authors.lastname: Ohara
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000556:secondary*; D005260:Female; D005500:Follow-Up Studies; D006119:Groin; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary*; D013848:Thigh; D014846:Vulvar Neoplasms / Q000473:pathology*