[Antioxidant properties of pharmacopoeia drugs--derivatives of the phenothiazine series].
Some pharmaceutical drugs--phenothiazine derivates--which have antioxidant properties were studied. One cannot eliminate the possibility, that such an effect of these drugs plays certain part in their action mechanism. Possible mechanisms of antioxidant effect of the drug are discussed proceeding from the study of kinetics of reactions of NADPH- and ascorbate-dependent peroxidation of lipids. There is a theoretical substantiation of the first-hand application of phenothiazine derivatives (among other neuroleptics) under the correction of psychoemotional stress and other states accompanied by the increase of lipid peroxidation.
Oliĭnyk
S A
SA
Zatsenko
D M
DM
Khmelevs'kyĭ
Iu V
IuV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D009249:NADP / Q000494:pharmacology; D010602:Pharmacopoeias as Topic; D010640:Phenothiazines; D012044:Regression Analysis; D013315:Stress, Psychological / Q000188:drug therapy; D014455:Ukraine
D000975:Antioxidants; D014150:Antipsychotic Agents; D010640:Phenothiazines; D009249:NADP; D001205:Ascorbic Acid
Antioksidantovi vlastyvosti farmakopeĭovykh preparativ-- pokhidnykh fenotyazynovoho riadu.