title: Distribution of immunocompetent cells in oral Kaposi's sarcoma (AIDS).
abstract: Fifteen biopsy specimens of oral AIDS-associated Kaposi's sarcoma (KS), 19 biopsy specimens of uninvolved oral mucosa of HIV-seropositive patients (HIV+) and 22 biopsy specimens of oral mucosa of HIV-seronegative persons (HIV-) were analysed for the distribution of CD4+ and CD8+ lymphocytes and HLA-DR+ cells. The results were statistically evaluated. According to their clinical appearance KS were classified as flat lesions (n = 10) or exophytic tumours (n = 5). KS lesions of both clinical groups as well as uninvolved mucosa of HIV+ patients revealed infiltration with CD4+ cells. In flat, patch-like KS there was a marked increase of CD8+ cells compared to HIV- mucosa, while their numbers decreased in later tumour stages. In both, flat and exophytic KS the number of HLA-DR+ cells was significantly higher than in uninvolved mucosa of HIV+ and HIV- persons. These findings may reflect the local influence of KS growth factors on the inflammatory reaction in the setting of systemic immunosuppression.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kagoshima University Dental School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tabata
authors.forename: A
authors.initials: A
authors.lastname: Langford
authors.forename: J
authors.initials: J
authors.lastname: Becker
authors.forename: P A
authors.initials: PA
authors.lastname: Reichart
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000704:Analysis of Variance; D000951:Antigens, Neoplasm / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes; D016827:CD8 Antigens / Q000032:analysis; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D009061:Mouth Mucosa / Q000276:immunology; D009062:Mouth Neoplasms / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D016176:T-Lymphocyte Subsets
chemical_list: D000951:Antigens, Neoplasm; D015704:CD4 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens