Increased activity of 5' nucleotidase in serum of patients with sickle cell anaemia.
Fifty-nine patients with homozygous sickle cell anaemia, 17 heterozygous individuals and 22 controls were investigated in respect to serum (S) 5'nucleotidase (5'NT, EC 3.1.3.5). The patients showed a significantly higher mean value of S-5'NT compared to the controls. However, this rise was heterogeneous as it occurred only among a subgroup of patients. The heterozygous individuals were not different from either the patients or the controls generating a situation which puts the heterozygous individuals in an intermediate position between the patients and the controls. S-5'NT showed significant correlation with S-bilirubin, S-aspartate aminotransferase, S-alanine aminotransferase and especially S-gammaglutamyl transferase. However, it was not correlated with S-alkaline phosphatase, which is another marker for hepatobiliary disease. These results suggest that the liver involvement in a subgroup of patients with sickle cell anaemia is a mixture of hepatocyte damage and the biliary tree involvement.
Mohamed
A O
AO
Department of Clinical Chemistry, Uppsala University, University Hospital, Sweden.
Jansson
A
A
Ronquist
G
G
D015720:5'-Nucleotidase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000755:Anemia, Sickle Cell / Q000150:complications / Q000201:enzymology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001660:Biliary Tract Diseases / Q000175:diagnosis* / Q000209:etiology; D001663:Bilirubin / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004796:Clinical Enzyme Tests; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology; D005723:gamma-Glutamyltransferase / Q000097:blood
D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D015720:5'-Nucleotidase; D001663:Bilirubin