title: Immunocytochemical detection of P-glycoprotein: initial expression correlates with survival in renal cell carcinoma patients.
abstract: We evaluated 28 patients with advanced renal cell carcinoma for the initial expression of P-glycoprotein (MDR1 gene product) employing immunocytochemistry. Tumor specimens were obtained upon primary tumor nephrectomy. In all patients, progression-free survival time following nephrectomy was evaluated and correlated statistically with the staining results. Progression-free survival of patients with no or very few (< 1%) P-glycoprotein-positive tumor cells (n = 8, median survival 27.0 months) was significantly extended (p < 0.04) as compared to patients with 1% or more P-glycoprotein-positive tumor cells (n = 20, median survival 4.0 months). Correlations with histopathological tumor characteristics were insignificant. These results suggest a potential role for P-glycoprotein as a biologic parameter predictive of tumor progression in renal cell carcinoma patients.
authors.affiliation: Department of Hematology and Oncology, Medizinische Hochschule Hannover, FRG.
authors.forename: S
authors.initials: S
authors.lastname: Duensing
authors.forename: I
authors.initials: I
authors.lastname: Dallmann
authors.forename: J
authors.initials: J
authors.lastname: Grosse
authors.forename: J
authors.initials: J
authors.lastname: Buer
authors.forename: E
authors.initials: E
authors.lastname: Lopez Hänninen
authors.forename: M
authors.initials: M
authors.lastname: Deckert
authors.forename: S
authors.initials: S
authors.lastname: Störkel
authors.forename: H
authors.initials: H
authors.lastname: Kirchner
authors.forename: H
authors.initials: H
authors.lastname: Poliwoda
authors.forename: J
authors.initials: J
authors.lastname: Atzpodien
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D002352:Carrier Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D015996:Survival Rate; D013997:Time Factors
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002352:Carrier Proteins; D008562:Membrane Glycoproteins