[Necrotic lesions, ischemia and reperfusion: effects of beta blockers].
The anti-ischemic properties of beta-blocking drugs have promoted their use during acute myocardial infarction. Beneficial effects are only observed with very early intravenous administration (less than 6 hours). Mortality is reduced by 14% and reinfarction by 18% during the 8 day post-infarction period. The incidence of ventricular fibrillation has been inconstantly decreased. Infarct size reduction is the most probable mechanism of beta-blockade induced protection. The thrombolytic-beta-blocker association seems to provide additional benefits compared with thrombolysis alone, but this remains to be demonstrated in large scale trials.
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Service de pharmacologie, hôpital Pitié-Salpêtrière, Paris.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D017202:Myocardial Ischemia / Q000188:drug therapy; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy; D012008:Recurrence
D000319:Adrenergic beta-Antagonists
Lésions de nécrose, ischémie et reperfusion: effets des bêtabloquants.