title: Noradrenergic modulation of avian kidney function.
abstract: Norepinephrine (NE) infused at doses of 0.7, 2.2 and 6.7 micrograms/min/kg body weight into conscious, salt and water loaded ducks dose-dependently induced arterial hypertension, reflex bradycardia and diuresis/natriuresis at unchanged glomerular filtration and reduced renal blood flow. NE-induced changes in plasma concentrations of osmoregulatory hormones consisted of a slight increase for the antidiuretic hormone, no change for angiotensin II and a nearly 4-fold increase for atrial natriuretic factor. Sub-pressor doses of NE infused close to the origin of the renal arteries induced diuresis without a rise in urinary sodium concentration. The results suggest pressure diuresis in ducks as a response to hypertensive NE doses with a possible contribution of atrial natriuretic factor to natriuresis.
authors.affiliation: Max-Planck-Institut für Physiologische und Klinische Forschung, W.G. Kerckhoff-Institut, Bad Nauheim, F.R.G.
authors.forename: D
authors.initials: D
authors.lastname: Jungbluth
authors.forename: C
authors.initials: C
authors.lastname: Simon-Oppermann
authors.forename: H
authors.initials: H
authors.lastname: Schütz
authors.forename: R
authors.initials: R
authors.lastname: Gerstberger
authors.forename: E
authors.initials: E
authors.lastname: Simon
mesh_terms: D000804:Angiotensin II / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004372:Ducks / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology* / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects; D014668:Vasotocin / Q000097:blood
chemical_list: D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D014668:Vasotocin; D009638:Norepinephrine