title: PUVA and methotrexate therapy of psoriasis: how closely do dermatology departments follow treatment guidelines? Psoriasis Audit Workgroup of the British Association of Dermatologists.
abstract: Following publication of treatment guidelines for patients with psoriasis, a six-centre audit was undertaken to assess current therapeutic practice for two second-line treatments, PUVA and methotrexate. The audit consisted of random sampling of casenotes by external auditors from a paired dermatology department, and assessment by questionnaire. One hundred and eight PUVA and 118 methotrexate casenotes were audited. The commonest indications for treatment were: (a) failure of tropical therapy--PUVA (mean 81% of casenotes), methotrexate (84%); (b) repeated hospital admissions--PUVA (16%), methotrexate (25%). For both PUVA and methotrexate, some aspects of treatment were well documented: PUVA--psoralen dosage (91%), response to PUVA (89%), cumulative lifetime UVA dosage (81%); methotrexate--pretreatment assessment of full blood count (91%), urea and electrolytes (85%), liver function tests (84%). For other aspects documentation was less complete: PUVA--no documentation of presence/absence of skin cancer history (66%), note of photoactive drugs (32%); methotrexate--concurrent medication (69%), history of presence/absence of liver disease (36%). Another aspect which was poorly documented in both PUVA and methotrexate notes was whether advice on contraception/fertility had been given. There was no indication in 29 of 32 casenotes of females of child-bearing age receiving PUVA, and 52 of 63 case notes of relevant patients on methotrexate. This project has demonstrated that formal, multicentre audit based on published guidelines is a practical proposition.
authors.affiliation: University Department of Dermatology, Western Infirmary, Glasgow, U.K.
authors.forename: D J
authors.initials: DJ
authors.lastname: Bilsland
authors.forename: L E
authors.initials: LE
authors.lastname: Rhodes
authors.forename: I
authors.initials: I
authors.lastname: Zaki
authors.forename: S M
authors.initials: SM
authors.lastname: Wilkinson
authors.forename: K E
authors.initials: KE
authors.lastname: McKenna
authors.forename: S E
authors.initials: SE
authors.lastname: Handfield-Jones
authors.forename: R E
authors.initials: RE
authors.lastname: Williams
mesh_terms: D002985:Clinical Protocols; D003880:Dermatology; D005260:Female; D006748:Hospital Departments; D006801:Humans; D008485:Medical Audit; D008727:Methotrexate / Q000627:therapeutic use*; D011701:PUVA Therapy / Q000379:methods*; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D008727:Methotrexate