[The effect of vasoactive preparations on the systemic and cerebral hemodynamics and on the blood rheological properties in patients with cerebrovascular insufficiency with a background of an atherosclerotic lesion of the precerebral arteries].
Vasoactive preparations (cavinton, corinfar, phinoptin, pentoxyphylline and sermion) were studied for their effect on systemic and cerebral hemodynamics in 232 patients with cerebrovascular insufficiency in the presence of atherosclerotic lesion of the precerebral arteries, and for that on rheologic properties of blood in 91 of them. It has been established that the highest effect from the use of calcium antagonists and sermion with respect of the blood flow linear velocity (BFLV) increase occurs predominantly in stenotic precerebral arteries; the normalization of the platelet-erythrocyte homeostasis is also considerably influenced by these. Calcium antagonists and sermion are capable of lowering arterial pressure, diminishing the volume of circulating blood and cardiac index thereby making for more economic heart performance. Cavinton has only minor effects on systemic hemodynamics, slightly increases BFLV reduces the extent of the erythrocyte aggregation only. Pentoxyphylline has a positive effect on normalization of platelet and erythrocyte homeostasis, reduces blood viscosity and does not influence the parameters of systemic hemodynamics, only slightly increases the linear velocity of the bloodflow in the precerebral arteries. Recommendations on the use of the preparations studied are presented.
Ishchenko
M M
MM
Shkrobot
S I
SI
Ostrovs'ka
O S
OS
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D001809:Blood Viscosity / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents
Vplyv vazoaktyvnykh preparativ na systemnu ta tserebral'nu hemodynamiku i reolohichni vlastyvosti krovi khvorykh z tserebrovaskuliarnoiu nedostatnistiu na foni aterosklerotychnoho urazhennia pretserebral'nykh arteriĭ.