Atrial natriuretic peptide inhibited the natriferic and hydrosmotic effects of arginine vasotocin on toad skin.
The effect of rat atrial natriuretic peptide (rANP) on hormonal stimulated osmotic water permeability (Jw, hydrosmotic effect) and net ion transport (short-circuit current, SCC, natriferic effect) was studied on toad skin, a tissue with functional similarities to the mammalian distal nephron, in order to assess actions on transport mechanisms. Rat atrial natriuretic peptide, rANP-99-126 (rANP) inhibited stimulated SCC and Jw to submaximal concentrations of arginine vasotocin (AVT) at a site before cyclic AMP generation. The angiotensin-converting enzyme inhibitor (ACEI) MK-422 did not modify the inhibitory effect of ANP in the stimulated Jw.
Berman
D M
DM
Departamento de Fisiología, INSIBIO, San Miguel de Tucumán, Argentina.
Soria
M O
MO
Proto de Grifasi
M
M
Coviello
A
A
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003994:Bucladesine / Q000494:pharmacology; D002022:Bufo arenarum; D000242:Cyclic AMP / Q000096:biosynthesis; D015773:Enalaprilat / Q000494:pharmacology; D005260:Female; D017136:Ion Transport / Q000187:drug effects; D008297:Male; D009995:Osmosis / Q000187:drug effects; D010539:Permeability / Q000187:drug effects; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology; D014668:Vasotocin / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D003994:Bucladesine; D009320:Atrial Natriuretic Factor; D012964:Sodium; D013806:Theophylline; D000242:Cyclic AMP; D015773:Enalaprilat; D014668:Vasotocin