title: Hepatic changes of mice in the subacute phase of streptozotocin (SZ)-induced diabetes.
abstract: Hepatic changes of mice in the subacute phase of streptozotocin (SZ)-induced diabetes were investigated biochemically and pathologically. Biochemically, the contents of serum glucose and of serum and liver lipids increased while the content of liver glycogen decreased in SZ-induced diabetic mice. Histopathologically, hypertrophy of hepatocytes due to an increase in number of intracytoplasmic acidophilic granules was common to SZ-induced diabetic mice. Electron microscopically, these hepatocytes were characterized by a prominent increase in number of mitochondria showing normal structure, a marked decrease of glycogen granules and poorly developed rough endoplasmic reticulum, which were common to so-called oncocytic cells. In some SZ-induced diabetic mice, bile duct hyperplasia with an appearance of cytomegalic hepatocytes was also observed.
authors.affiliation: Research Laboratory of Drug Metabolism, Tanabe Seiyaku Co. Ltd., Saitama, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Kume
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmachi
authors.forename: S
authors.initials: S
authors.lastname: Itagaki
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Doi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000473:pathology*; D004721:Endoplasmic Reticulum / Q000187:drug effects; D006003:Glycogen / Q000032:analysis; D006984:Hypertrophy / Q000473:pathology; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008854:Microscopy, Electron; D009929:Organ Size / Q000187:drug effects; D013311:Streptozocin / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D008055:Lipids; D013311:Streptozocin; D006003:Glycogen