Tumour-associated antigens in maternal and fetal blood.
Normal levels of cancer-associated antigen (CA) 19-9, neurone-specific enolase (NSE), cancer-associated antigen (CA) 125, and mucin-like carcinoma-associated antigen (MCA) during pregnancy were determined in 87 mothers and fetuses, using a solid-phase sandwich enzyme immunoassay. CA 19-9 concentrations were higher in the fetuses, whereas the other three tumour-associated antigen levels were higher in the mothers. Only fetal NSE and MCA levels were positively correlated with those in maternal serum. Contrary to adult samples, no difference was demonstrated between male and female fetal levels of CA 125. MCA was the only maternal marker that increased significantly with gestational age between 20 and 34 weeks' pregnancy.
Hohlfeld
P
P
Laboratoire d'Hématologie, Université de Paris-Sud, Faculté de Chatenay Malabry, France.
Dang
T T
TT
Nahoul
K
K
Daffos
F
F
Forestier
F
F
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011247:Pregnancy; D012016:Reference Values
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; C057387:mucinous carcinoma-associated antigen; D010751:Phosphopyruvate Hydratase