title: Concentration-dependent effects of 9-cis retinoic acid on neuroblastoma differentiation and proliferation in vitro.
abstract: The observation that neuroblastoma cells differentiate in response to retinoic acid (RA) in vitro has led to clinical trials using either 13-cis or all-trans RA. Since 9-cis RA may also have important biological functions, we have compared the potential of RA isomers to induce differentiation and inhibit cell proliferation of SH SY 5Y neuroblastoma cells. 9-cis RA at high concentrations is better at inducing morphological differentiation than either all-trans or 13-cis RA and as effective at inhibiting proliferation. Hence, 9-cis RA or stable analogues may have important therapeutic potential in the treatment of neuroblastoma.
authors.affiliation: Medical Molecular Biology Group, Medical School, University of Newcastle, Newcastle-upon-Tyne, UK.
authors.forename: P E
authors.initials: PE
authors.lastname: Lovat
authors.forename: S P
authors.initials: SP
authors.lastname: Lowis
authors.forename: A D
authors.initials: AD
authors.lastname: Pearson
authors.forename: A J
authors.initials: AJ
authors.lastname: Malcolm
authors.forename: C P
authors.initials: CP
authors.lastname: Redfern
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D009447:Neuroblastoma / Q000473:pathology*; D009994:Osmolar Concentration; D013237:Stereoisomerism; D014212:Tretinoin / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D014212:Tretinoin