Atopic dermatitis--immunological abnormality and its background.
The production of IgE is mainly regulated by cognate and/or non-cognate interaction between B cells and T cells. Two types of helper T cells are recognized in the murine system, Th1 and Th2, by the type of cytokine they produce. Several lines of evidence disclosed that unbalanced generation of Th2/Th1-like cells occurs in atopic disorders, such as atopic dermatitis, in which a high level of serum IgE is found in the majority of patients. Analysis of skin-derived immunocompetent cells, such as Langerhans cells and T cells, has provided us with a new understanding of the pathophysiology of atopic dermatitis. The recent progress in immunological aspects of atopic dermatitis is reviewed.
Furue
M
M
Department of Dermatology, Yamanashi Medical University, Japan.
D000818:Animals; D016207:Cytokines / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D015847:Interleukin-4 / Q000502:physiology; D007801:Langerhans Cells / Q000502:physiology; D051379:Mice; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D012867:Skin / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology / Q000502:physiology
D016207:Cytokines; D015847:Interleukin-4; D007073:Immunoglobulin E; D010727:Phosphoric Diester Hydrolases