title: Analgesic and anti-inflammatory effects of 3-[3-(phenyl)-1,2,4-oxadiazol-5-yl] propionic acid.
abstract: Significant local analgesic and anti-inflammatory activity has been observed after oral administration of 3-[3-(phenyl)-1,2,4-oxadiazol-5-yl] propionic acid (POPA). Doses of 150 and 300 mg/kg body weight administered orally by gavage to adult (25-35 g) albino mice of both sexes can inhibit acetic acid-induced writhing by 31.0% and 49.5%, respectively (mean +/- SEM writhing numbers during 20 min were 52.0 +/- 6.0 and 38.3 +/- 7.2 vs 75.8 +/- 6.6 for control group which received saline; N = 6). Carrageenin-induced inflammation in the female Wistar rat (200-250 g) can be reduced by 43.3% and 42.2% 3 h after oral administration (gavage) of 75 and 150 mg/kg of POPA (mean +/- SEM, 30.0 +/- 1.3% and 30.6 +/- 2.4% vs 52.9 +/- 3.7% for control group which received saline; N = 5). In the hot plate test on adult albino mice (25-35 g) of both sexes, POPA (150 and 300 mg/kg, po) was totally ineffective (N = 10). Our results indicate that POPA appears to offer potential safety and efficacy as a local analgesic and anti-inflammatory agent with no central nervous system involvement
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco Recife, Brasil.
authors.forename: P
authors.initials: P
authors.lastname: Afiatpour
authors.forename: R M
authors.initials: RM
authors.lastname: Srivastava
authors.forename: M L
authors.initials: ML
authors.lastname: de-Oliveira
authors.forename: E J
authors.initials: EJ
authors.lastname: Barreiro
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010069:Oxadiazoles / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: C092645:3-(3-phenyl-1,2,4-oxadiazol-5-yl)propionic acid; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010069:Oxadiazoles