T-cell-T-cell collaboration in allograft responses.
T-cell-T-cell collaboration in allogeneic responses traditionally has been viewed as the requirement for CD4+ T helper cells in the activation of CD8+ cytotoxic T cells. In this regard, the role of the CD4+ T cell is primarily to provide growth factors, such as interleukin-2, on which the CD8+ T cell is dependent. However, expanding information concerning the function of T-cell subsets, and the roles of antigen-presenting cells and cytokines in regulating immune responses, requires that the basic tenets of T-cell interactions be re-evaluated.
Gill
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Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002450:Cell Communication; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007109:Immunity; D008213:Lymphocyte Activation / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology*
D016207:Cytokines