title: Actin assembly in response to extracellular signals: role of capping proteins, thymosin beta 4 and profilin.
abstract: In motile non-muscle cells, G-actin sequestering proteins, capping proteins and profilin regulate actin assembly in response to extracellular signals. The regulation of actin sequestration/assembly is performed via the control of the concentration of free G-actin at steady-state. The increase in free G-actin mediated by capping proteins results in an increased sequestration of actin. When barbed ends are uncapped upon cell stimulation, the participation of profilin-actin in filament assembly causes a decrease in free G-actin, which results in the depletion of the pool of sequestered actin and concomitant increase in the F-actin pool.
authors.affiliation: Laboratoire d'Enzymologie du CNRS, Gif-sur-Yvette, France.
authors.forename: M F
authors.initials: MF
authors.lastname: Carlier
authors.forename: D
authors.initials: D
authors.lastname: Pantaloni
mesh_terms: D051339:Actin Depolymerizing Factors; D000199:Actins / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003285:Contractile Proteins / Q000502:physiology; D051345:Destrin; D008840:Microfilament Proteins / Q000502:physiology*; D051304:Profilins; D015398:Signal Transduction / Q000502:physiology*; D013947:Thymosin / Q000502:physiology*; D000099201:Thymosin beta(4)
chemical_list: D051339:Actin Depolymerizing Factors; D000199:Actins; D000255:Adenosine Triphosphate; D003285:Contractile Proteins; D051345:Destrin; D008840:Microfilament Proteins; D051304:Profilins; D013947:Thymosin; D000099201:Thymosin beta(4)