End-tidal partial pressure of carbon dioxide does not accurately reflect PaCO2 in rabbits treated with acetazolamide during anaesthesia.
Acetazolamide, a carbonic anhydrase inhibitor, may cause significant disturbances in carbon dioxide transport and elimination. In this study, end-tidal carbon dioxide monitoring has been used to study the correlation between arterial carbon dioxide (PaCO2) and end-tidal carbon dioxide partial pressure (PE'CO2) in rabbits treated with acetazolamide. A significant difference in (PaCO2-PE'CO2) developed immediately after administration of acetazolamide and persisted for more than 2 h. It is concluded that PE'CO2 did not reflect accurately PaCO2 and the ventilatory status of the rabbit which received acetazolamide within 2 h.
Lee
T S
TS
Department of Anesthesiology, Harbor-UCLA Medical Center, Torrance 90509-2910.
D000086:Acetazolamide / Q000494:pharmacology*; D000768:Anesthesia, General; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood / Q000502:physiology*; D008991:Monitoring, Physiologic; D010313:Partial Pressure; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D011817:Rabbits
D002245:Carbon Dioxide; D000086:Acetazolamide