Subnormal serum concentration of 1,25-vitamin D in human immunodeficiency virus infection: correlation with degree of immune deficiency and survival.
Vitamin D metabolites, immunologic, virologic, and clinical parameters, and survival time were determined in 22 asymptomatic human immunodeficiency virus (HIV)-infected patients (CDC stage II/III), 31 symptomatic HIV-infected patients (CDC stage IV), and 28 HIV-seronegative controls. Significantly lower serum levels of 1,25-vitamin D (1,25D) were found in symptomatic patients (median, 34 pg/mL; 25th-75th percentile, 21-45) compared with controls (49 pg/mL; 39-59) and asymptomatic patients (45 pg/mL; 42-50). In HIV-infected subjects, the serum level of 1,25D was positively correlated with CD4+ cell counts in peripheral blood (r = .35, P < .05) and negatively correlated with the level of serum neopterin (r = -.36, P < .01). HIV-infected patients with abnormally low 1,25D (< 25 pg/mL) also had shorter survival times than other HIV-infected subjects (P < .01). Low 1,25D levels did not appear to be related to vitamin D deficiency.
Haug
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C
Kaptein Wilhelmsen og Frues Institute of Bacteriology, Medical Department A, University of Oslo, National Hospital, Norway.
Müller
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Aukrust
P
P
Frøland
S S
SS
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000401:mortality; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D015496:CD4-Positive T-Lymphocytes; D002117:Calcitriol / Q000097:blood*; D005500:Follow-Up Studies; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000401:mortality; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D007958:Leukocyte Count; D019798:Neopterin; D009748:Nutrition Disorders / Q000150:complications; D016016:Proportional Hazards Models; D016019:Survival Analysis; D050378:T-Lymphocytes, Regulatory
D001708:Biopterins; D019798:Neopterin; D002117:Calcitriol; D007654:Ketoconazole