Effects of sotalol and d-sotalol on ventricular tachycardia and fibrillation induced by programmed electrical stimulation.
It is only in the last few years that the broad-spectrum antiarrhythmic properties of sotalol have become increasingly recognized. Racemic sotalol has potent beta-blocking and class III antiarrhythmic properties, and it has been reported that this drug is able to control supraventricular and ventricular arrhythmias. Recently, several studies performed with the d-sotalol isomer, which is almost devoid of the beta-blocking effects compared to the racemate, suggest significant antiarrhythmic efficacy and good tolerance of the dextro-isomer. In this paper we review and discuss the effects of sotalol and d-sotalol in patients with ventricular tachycardia (VT), ventricular fibrillation (VF) or cardiac arrest in whom VT or VF was induced by programmed electrical stimulation (PES).
Aliot
E
E
Service de Cardiologie, Hôpital Central, Nancy, France.
Sadoul
N
N
De Chillou
C
C
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002304:Cardiac Pacing, Artificial; D002986:Clinical Trials as Topic; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013015:Sotalol / Q000737:chemistry / Q000627:therapeutic use*; D013237:Stereoisomerism; D017180:Tachycardia, Ventricular / Q000188:drug therapy* / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists; D013015:Sotalol