Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice.
Persistent infection was established in SCID mice given 10(7) Cryptosporidium parvum oocysts. Nine groups of infected SCID mice were inoculated with 10(6), 10(5), or 10(4) total spleen cells, CD8-depleted spleen cells, or CD4-depleted spleen cells from naive BALB/c donors. Infection was significantly reduced in all treatment groups. The most profound effect occurred with spleen cell preparations containing CD4 T lymphocytes but depleted of CD8 T lymphocytes.
Perryman
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LE
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
Mason
P H
PH
Chrisp
C E
CE
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D016827:CD8 Antigens / Q000032:analysis; D003457:Cryptosporidiosis / Q000276:immunology*; D016785:Cryptosporidium parvum; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology* / Q000637:transplantation
D016827:CD8 Antigens