Beta blocker inhibits tricyclic metabolism.
Significant inhibition of tricyclic antidepressant metabolism by beta blockers has not often been cited in the literature and never in a clinical setting. We will describe two cases involving 9-year-old patients who experienced apparent inhibition of imipramine metabolism and near-toxic levels while receiving both propranolol and imipramine.
Gillette
D W
DW
University of New Mexico School of Medicine, Albuquerque.
Tannery
L P
LP
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000374:Aggression / Q000187:drug effects; D000786:Anger / Q000187:drug effects; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D007099:Imipramine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011433:Propranolol / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000188:drug therapy / Q000523:psychology
D000319:Adrenergic beta-Antagonists; D000929:Antidepressive Agents, Tricyclic; D011433:Propranolol; D007099:Imipramine