title: Trimetrexate in advanced hormone-refractory prostate cancer. An ECOG phase II trial.
abstract: The antitumor activity and toxicity of trimetrexate (TMTX) was evaluated in measurable, hormone-refractory, advanced prostate cancer patients. Patients were required to have an ECOG performance status < 3, bidimensionally measurable disease, serum creatinine < or = 1.5 mg/dL, normal bone marrow function, and adequate hepatic function. Prior non-hormonal systemic therapy, active infection, third space effusions were exclusion criteria. TMTX 12 mg/m2 daily for five days (8 mg/m2 for patients with any prior radiation therapy or age > or = 75 years) was administered every 3 weeks. There were no responses in the 18 eligible patients. Median time to treatment failure and median survival were 6 and 20 weeks, respectively. Myelosuppression was the most frequent toxicity observed and was mild to severe in all but 4 patients. Two patients whom experienced life-threatening reversible leukopenia and grade 4 thrombocytopenia developed in 2 further patients. Non-hematologic toxicity was also reversible and was mild to severe. TMTX at this dose and schedule is inactive in advanced, hormone-refractory prostate cancer.
authors.affiliation: University of Wisconsin Comprehensive Cancer Center, Madison.
authors.forename: R S
authors.initials: RS
authors.lastname: Witte
authors.forename: B Y
authors.initials: BY
authors.lastname: Yeap
authors.forename: D L
authors.initials: DL
authors.lastname: Trump
mesh_terms: D000368:Aged; D000740:Anemia / Q000139:chemically induced; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013921:Thrombocytopenia / Q000139:chemically induced; D017211:Treatment Failure; D016597:Trimetrexate / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D016597:Trimetrexate