title: Disseminated intravascular coagulation in Still's disease.
abstract: Still's disease is characterized by arthritis, fever, rash, lymphoid hypertrophy, leukocytosis, and anemia, often in association with thrombocytosis. We describe a patient with Still's disease and thrombocytopenia secondary to disseminated intravascular coagulation (DIC). Fifteen definite cases of DIC complicating Still's disease have been reported in the English literature. Most developed this complication while receiving high doses of salicylates in association with hepatic dysfunction. In a few, the coagulopathy has been associated with gold therapy. Our patient is only the second reported to develop DIC in the absence of drug therapy and the fourth reported to die from this complication. The clinical features of these 16 patients are summarized and proposed mechanisms of pathogenesis are reviewed.
authors.affiliation: Department of Medicine, Fitzsimons Army Medical Center, Aurora, CO 80045-5001.
authors.forename: V J
authors.initials: VJ
authors.lastname: Bray
authors.forename: J D
authors.initials: JD
authors.lastname: Singleton
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications* / Q000503:physiopathology; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D013921:Thrombocytopenia / Q000209:etiology