Intrauterine device use and risk of endometrial cancer.
The relationship between intrauterine device (IUD) use and risk of endometrial cancer has been analysed in a case-control study conducted in Italy between 1983 and 1992, including 453 patients with histologically confirmed endometrial cancer and 1,451 controls admitted for acute, non-gynaecological, non-hormonal, non-neoplastic conditions to the same network of hospitals where cases had been identified. Two (0.4%) cases versus 36 (2.3%) controls reported ever using an IUD. The corresponding multivariate relative risk was 0.4 (95% CI 0.1-1.0). The results of this study and the few published available epidemiological data suggest a protective role of IUD use on endometrial carcinogenesis, but potential selective mechanisms for IUD utilisation (indication bias) should be carefully considered in the interpretation.
Parazzini
F
F
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
La Vecchia
C
C
Moroni
S
S
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D007434:Intrauterine Devices / Q000009:adverse effects*; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D012307:Risk Factors