Translation factors as effectors of cell growth and tumorigenesis.
Regulation of translation plays an important role in controlling gene expression. Recent data show that deregulation of translation factor activity leads to drastic changes in cell growth, including transformation and tumorigenesis.
Sonenberg
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McGill University, Montreal, Canada.
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism; D039561:Eukaryotic Initiation Factor-4E; D005786:Gene Expression Regulation / Q000502:physiology*; D008954:Models, Biological; D020648:Peptide Elongation Factor 1; D010445:Peptide Elongation Factors / Q000235:genetics / Q000502:physiology*; D010448:Peptide Initiation Factors / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011519:Proto-Oncogenes; D019892:eIF-2 Kinase
D039561:Eukaryotic Initiation Factor-4E; D020648:Peptide Elongation Factor 1; D010445:Peptide Elongation Factors; D010448:Peptide Initiation Factors; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase