Age-dependent expression, phosphorylation and function of neurotransmitter receptors: pharmacological implications.
In recent years, a number of experimental controversies have arisen in the pharmacological sciences literature. Two possibly related examples concern the role of phosphorylation in receptor regulation and the occurrence of paradoxical effects of neurally active drugs in patients. In this article, Ruth Lanius and colleagues review these two issues and suggest that some of the recently reported age-dependent aspects of neurotransmitter receptor regulation and function may explain drug action. An appreciation of the dynamic interactions involved in receptor regulation, especially during development, may offer novel perspectives on neural function.
Lanius
R A
RA
Neuroscience Program, University of British Columbia, Vancouver, Canada.
Pasqualotto
B A
BA
Shaw
C A
CA
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism / Q000494:pharmacology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000494:pharmacology*; D010766:Phosphorylation; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D000928:Antidepressive Agents; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter