title: Tc-99m MIBI scintigraphic detection of metastatic insular thyroid carcinoma.
abstract: Thallium-201 and, recently, Tc-99m MIBI have been used in conjunction with I-131 scintigraphy for follow-up of patients with well-differentiated thyroid cancer. Insular carcinoma of the thyroid is a fairly aggressive thyroid neoplasm that is believed to arise from follicular cells and usually concentrates I-131. The authors report a patient with recurrent insular thyroid carcinoma in whom bilateral adrenal and lung metastatic lesions developed 3 years after ablative I-131 therapy for cervical lymph node and skeletal metastases. Tc-99m MIBI planar and SPECT images demonstrated these new lesions better than pretherapy I-131 scintigraphy and affords an imaging technique for post-I-131 therapy follow-up that does not require withholding thyroid hormone suppression.
authors.affiliation: Department of Radiology, University of Iowa College of Medicine, Iowa City 52242.
authors.forename: I T
authors.initials: IT
authors.lastname: Zak
authors.forename: J E
authors.initials: JE
authors.lastname: Seabold
authors.forename: N J
authors.initials: NJ
authors.lastname: Gurll
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging / Q000556:secondary; D000310:Adrenal Gland Neoplasms / Q000556:secondary; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000532:radiotherapy / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy
chemical_list: D007457:Iodine Radioisotopes; D017256:Technetium Tc 99m Sestamibi