title: Beta adrenergic stimulation and blockade in cirrhosis: effects on azygos vein blood flow and portal hemodynamics.
abstract: It is unknown whether beta adrenergic stress has adverse hepatic hemodynamic effects. Therefore, the authors studied the hemodynamic effects of beta adrenergic stimulation and subsequent blockade in 10 patients with cirrhosis (6 Childs A, 3 Childs B, and 1 Childs C) with known or suspected portal hypertension. Free and wedged hepatic vein pressures, hepatic venous pressure gradient, heart rate, mean arterial pressure, cardiac output, and azygos vein blood flow were measured at rest and after isoproterenol infusion (mean dose = 7.3 micrograms/min: target heart rate = 150% to 200% of resting heart rate). Esmolol, an ultra-short-acting beta blocker, was then infused (dose titrated to return heart rate to baseline), and all measurements were repeated. Based on the results, the authors conclude that beta adrenergic stress provoked by isoproterenol infusion significantly increases azygos vein blood flow and hepatic venous pressure gradient. Beta blockade with esmolol reduces azygos vein blood flow and hepatic venous pressure gradient significantly below baseline.
authors.affiliation: Department of Medicine, New York VA Medical Center, New York.
authors.forename: E H
authors.initials: EH
authors.lastname: Weinshel
authors.forename: H M
authors.initials: HM
authors.lastname: Altszuler
authors.forename: R F
authors.initials: RF
authors.lastname: Raicht
authors.forename: S P
authors.initials: SP
authors.lastname: Sedlis
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D001401:Azygos Vein; D006439:Hemodynamics; D006801:Humans; D006975:Hypertension, Portal / Q000503:physiopathology*; D007545:Isoproterenol / Q000494:pharmacology; D008103:Liver Cirrhosis / Q000503:physiopathology*; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D007545:Isoproterenol; C036604:esmolol