A beneficial effect of metipranolol pretreatment on rat kidney ischemia in vivo.
D,L-propranolol protects kidney against warm ischemia. On the contrary beta-blockers without membrane stabilizing activity (timolol, L-propranolol) do not possess this protective ability. The aim of the present work was to test the potential anti-ischemic properties of metipranolol, another beta-blocker with membrane stabilizing component. Metipranolol (1 mg/kg) was given 30 min prior to inducing the ischemia of left rat kidney followed with a contralateral nephrectomy. This pretreatment lowered the creatinemia as measured 24 hr after 60 min ischemia and improved the survival of rats after 90 min renal ischemia. The results are compatible with the concept that the membrane stabilizing activity may play a crucial role in the protective action of beta-blockers.
Tilser
I
I
Department of Pharmacology, Medical Faculty of Charles University, Hradec Králové.
Martínková
J
J
Chládek
J
J
Zaydlar
K
K
D000818:Animals; D005260:Female; D007511:Ischemia / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply*; D016030:Kidney Transplantation; D014290:Metipranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D014290:Metipranolol