Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T.
Brain glutamate and glutamine were detected in healthy human volunteers in spectroscopic images with a nominal voxel size of 2.25 cm3 at an echo time of 15 ms. Due to the increased frequency separation and simplification of J-coupling patterns, the separate detection of brain glutamate and glutamine at short echo times was possible. Creatine, choline, and N-acetylaspartate with other N-acetylated compounds were also detected. The ratios of the metabolite resonance intensities were in agreement with previously published values.
Mason
G F
GF
Department of Medicine, University of Alabama at Birmingham 35294.
Pan
J W
JW
Ponder
S L
SL
Twieg
D B
DB
Pohost
G M
GM
Hetherington
H P
HP
D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D005971:Glutamates / Q000032:analysis*; D018698:Glutamic Acid; D005973:Glutamine / Q000032:analysis*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D018377:Neurotransmitter Agents / Q000032:analysis*; D012815:Signal Processing, Computer-Assisted
D005971:Glutamates; D018377:Neurotransmitter Agents; D005973:Glutamine; D018698:Glutamic Acid