Cell types in the central nervous system infected by murine retroviruses: implications for the mechanisms of neurodegeneration.
Retroviruses are an important cause of neurologic disease in humans but the pathogenic mechanisms are poorly understood. To delineate pathogenic mechanisms in any neurologic disease in humans is extremely difficult and will continue to rely on the use of animal models. This review presents several murine models to study the pathogenic mechanisms of neurodegenerative disease which manifest noninflammatory spongiform lesions in the CNS. The cell types in the CNS infected by these murine retroviruses and their role in disease induction are discussed.
Wong
P K
PK
University of Texas, M.D. Anderson Cancer Center, Science Park-Research Division, Smithville.
Yuen
P H
PH
D000818:Animals; D002490:Central Nervous System / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D009052:Leukemia Virus, Murine / Q000302:isolation & purification / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D009410:Nerve Degeneration / Q000502:physiology*; D012192:Retroviridae Infections / Q000473:pathology; D014412:Tumor Virus Infections / Q000473:pathology