title: [Antiphospholipid antibodies in megakaryocytic thrombopenias].
abstract: We investigated the prevalence of antiphospholipid antibodies (APA) in megakaryocytic thrombopenias in order to establish their clinical significance and prognostic value. We studied 82 thrombopenic patients: 38 women and 44 men (age: 17-91 years). We assessed circulating lupus antibody (LA) through thromboplastin inhibition test (TIT), anticardiolipin antibodies (ACL) through ELISA and antiplatelet antibodies through flow cytometer. We conducted a statistical study RSIGMA, comparing patients with ACL + against ACL-. We found ACL positive in 21%, LA in 33% and antiplatelet antibodies in 42%. We observed a direct correlation (p < 0.05) between ACL and LA and between ACL and anticore antibodies, but not between ACL and antiplatelet antibodies. There was also a significant correlation between ACL and abortion, thrombosis and bleeding in thrombopenic patients. We conclude that APAs are present in 39% of the megakaryocytic thrombopenias and that they are not correlated with antiplatelet antibodies. Positivity of APA in thrombopenic patients is associated to poor prognosis and long term follow-up.
authors.affiliation: Departamento de Medicina, Hospital Militar Universitario Gómez Ulla, Universidad Complutense, Madrid.
authors.forename: C
authors.initials: C
authors.lastname: Pérez de Oteyza
authors.forename: I
authors.initials: I
authors.lastname: López Valero
authors.forename: J L
authors.initials: JL
authors.lastname: Romero Barbero
authors.forename: E
authors.initials: E
authors.lastname: Marcos Herrero
authors.forename: R
authors.initials: R
authors.lastname: Muro García
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D001327:Autoimmune Diseases / Q000145:classification / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000276:immunology*; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D013030:Spain / Q000453:epidemiology; D013921:Thrombocytopenia / Q000145:classification / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*
chemical_list: D017152:Antibodies, Antiphospholipid
vernacular_title: Anticuerpos antifosfolípidos en las trombopenias megacariocíticas.