Structural characterization of the decomposition products of salbutamol by liquid chromatography-ion-spray mass spectrometry.
Liquid chromatography-ion-spray mass spectrometry was used to elucidate the structures of the decomposition products of salbutamol. The best sensitivity in mass spectrometry was achieved by using a mixture of acetonitrile and ammonium formate (10 mM, pH 3.3) as the mobile phase in liquid chromatography. Fragmentation of the compounds was obtained by increasing the nozzle voltage in the first vacuum stage of the mass spectrometer. Tentative structure elucidation showed that both acidic and basic decomposition products are formed from salbutamol.
Mälkki-Laine
L
L
Department of Pharmacy, University of Helsinki, Finland.
Bruins
A P
AP
D000420:Albuterol / Q000737:chemistry*; D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D013056:Spectrophotometry, Ultraviolet
D000420:Albuterol