title: Cyclopropamitosenes: novel bioreductive anticancer agents--mechanism of action and enzymic reduction.
abstract: The mechanism of action of cyclopropamitosenes, novel bioreductive anticancer agents, has been investigated using a unique combination of chemical and biochemical techniques. The compounds 4 function as reductively activated alkylating agents under chemical reducing conditions, and the biochemical experiments establish that the methoxy- and aziridinyl-derivatives 4a and 4b behave differently upon bioreduction.
authors.affiliation: Department of Chemistry, Loughborough University of Technology, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Moody
authors.forename: N
authors.initials: N
authors.lastname: O'Sullivan
authors.forename: I J
authors.initials: IJ
authors.lastname: Stratford
authors.forename: M A
authors.initials: MA
authors.lastname: Stephens
authors.forename: P
authors.initials: P
authors.lastname: Workman
authors.forename: S M
authors.initials: SM
authors.lastname: Bailey
authors.forename: A
authors.initials: A
authors.lastname: Lewis
mesh_terms: D000477:Alkylating Agents / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology*; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D008937:Mitomycins / Q000378:metabolism* / Q000494:pharmacology*; D010084:Oxidation-Reduction
chemical_list: D000477:Alkylating Agents; D000970:Antineoplastic Agents; D008937:Mitomycins