Experimental study by fluorescence microscopy and microangiography of remodeling and regeneration of bone inside alloplastic contour augmentations.
Five female Göttingen minipigs received unilateral subperiosteal implantation of a block of porous hydroxyapatite covered by a polylactic membrane. Five months later, biopsies were taken from the blocks, which were left in place for another 3 months. The biopsies showed bone formation in all pores, indicating complete penetration of the blocks after 5 months. Highly vascular tissue with radiographic signs of bone resorption was found in the upper third of the augmentation 3 months later. Fluorescence microscopy showed that all sequential labels were present throughout the whole block. However, a significant decrease in the frequency of the 1-week label was recorded, showing that elevation of the overlying soft tissue may lead to temporary impairment of vascular supply.
Schliephake
H
H
Department of Oral and Maxillofacial Surgery, University Medical School, Hanover, Germany.
Kröly
C
C
Wüstenfeld
H
H
D000792:Angiography; D000818:Animals; D001672:Biocompatible Materials; D016723:Bone Remodeling / Q000502:physiology*; D005260:Female; D048091:Guided Tissue Regeneration; D006882:Hydroxyapatites; D008334:Mandible / Q000098:blood supply / Q000601:surgery*; D008833:Microcirculation; D008856:Microscopy, Fluorescence; D019736:Prostheses and Implants; D013552:Swine; D013556:Swine, Miniature
D001672:Biocompatible Materials; D006882:Hydroxyapatites