title: Osteosarcoma of the diaphysis of long bones: clinicopathologic features and treatment of 51 cases.
abstract: Of 1000 osteosarcoma cases recorded in the Mayo Clinic records, approximately 7% of the lesions occurred in the diaphysis of long bones, mostly in the femur, tibia, and humerus. The average age of the patients with these lesions was 28 years (range: 8 to 67). The duration of their symptoms before diagnosis was greater than that for patients with conventional osteosarcoma in the metaphysis. In approximately 20% of the cases, the radiographic appearance mimicked that of Ewing's sarcoma. Amputation surgery was the major form of treatment. The 2-, 5- and 15-year survival was 42%, 29%, and 20%, respectively.
authors.affiliation: Department of Orthopedics, Mayo Clinic, Rochester, MN 55905.
authors.forename: F H
authors.initials: FH
authors.lastname: Sim
authors.forename: F J
authors.initials: FJ
authors.lastname: Frassica
authors.forename: K K
authors.initials: KK
authors.lastname: Unni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging; D006801:Humans; D006811:Humerus; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D011859:Radiography; D011867:Radioisotope Teletherapy; D013977:Tibia