Compatibility of morphine, baclofen, floxuridine and fluorouracil in an implantable medication pump.
Studies were performed with a pump designed as a flow regulated implantable pump with a reservoir of 30 ml (VIP 30) for the continuous long term drug application in out-patients. The device consists of a gas driven two-chamber system containing the drug solution in one chamber and the propellant in the other. At body temperature the propellant underlies an isobaric expansion, thus creating pressure towards the impermeable, flexible membrane that separates the two chambers. Subsequently the pharmaceutical preparation is transported via a catheter to the target organ. With regard to its use as an implantable medication pump, four such devices were filled with solutions of morphine, baclofen, floxuridine, and fluorouracil, while one blank was filled with sterile water. The stability of the solutions and their compatibility with the pump materials was then examined. With a delivery rate of 1 ml/24 h, the pump is completely emptied after 30 days. Storage was at 37 degrees C and a number of values were obtained during the twice-normal period of 8 weeks; the content of active substances as well as any other products that had developed was determined with an optimized HPLC method. The chromatographic separations were done with two different eluents per substance. For each substance, individual samples from different periods of time were also chromatographed for up to 1 h and scanned at different wavelengths. All four pharmaceutical solutions were found stable after 30 days, only floxuridine showed a decomposition product after 7 weeks' storage.(ABSTRACT TRUNCATED AT 250 WORDS)
Sadjak
A
A
Institute for General and Experimental Pathology, Karl-Franzens University, Graz, Austria.
Wintersteiger
R
R
D001418:Baclofen / Q000008:administration & dosage* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004344:Drug Incompatibility; D004355:Drug Stability; D005467:Floxuridine / Q000008:administration & dosage* / Q000737:chemistry*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000737:chemistry*; D015918:Infusion Pumps, Implantable; D009020:Morphine / Q000008:administration & dosage* / Q000737:chemistry*; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
D012996:Solutions; D005467:Floxuridine; D009020:Morphine; D001418:Baclofen; D005472:Fluorouracil