Cutaneous photosensitivity in dermatomyositis.
The incidence and nature of cutaneous photosensitivity were studied in 10 patients suffering from dermatomyositis. Five reported an abnormality, which consisted of photoaggravation of preexisting cutaneous lesions in three, and abnormal transient erythemal responses in two. Monochromatic irradiation testing of all 10 patients demonstrated reduced minimal erythemal doses in two, at 307.5 nm, and at 340 and 360 nm, respectively; only the latter individual had clinical light sensitivity. Exposure to low-dose, solar-simulated radiation of the unaffected skin of the former patient, and five others who agreed to the procedure, three of whom complained of light sensitivity, induced a lesion with the clinical and immunofluorescence characteristics of dermatomyositis in only the first one. Four other patients replied to a mailed questionnaire, and three of these reported aggravation of their rash and provocation of new lesions by sunlight. Photosensitivity may thus be an important cutaneous feature of dermatomyositis.
Cheong
W K
WK
Photobiology Department, St John's Institute of Dermatology, London, U.K.
Hughes
G R
GR
Norris
P G
PG
Hawk
J L
JL
D000328:Adult; D000368:Aged; D003882:Dermatomyositis / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology