title: The number of noradrenergic and adrenergic neurons in the brain stem does not change with age in male Sprague-Dawley rats.
abstract: We examined whether or not the number of noradrenergic and adrenergic neurons changes with age, using peroxidase antiperoxidase (PAP) immunohistochemistry with specific antisera against tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT). TH- and PNMT-immunoreactive neurons were counted in every noradrenergic and adrenergic neuron group of young (3-month-old) and old (24-month-old) rats. The differences in the counted number of TH- and PNMT-immunoreactive neurons did not reach statistical significance between the young and old rats.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Monji
authors.forename: N
authors.initials: N
authors.lastname: Morimoto
authors.forename: I
authors.initials: I
authors.lastname: Okuyama
authors.forename: K
authors.initials: K
authors.lastname: Umeno
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Ibata
authors.forename: N
authors.initials: N
authors.lastname: Tashiro
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001933:Brain Stem / Q000166:cytology*; D002452:Cell Count; D004837:Epinephrine / Q000502:physiology*; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000166:cytology*; D009638:Norepinephrine / Q000502:physiology*; D010625:Phenylethanolamine N-Methyltransferase / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
chemical_list: D014446:Tyrosine 3-Monooxygenase; D010625:Phenylethanolamine N-Methyltransferase; D009638:Norepinephrine; D004837:Epinephrine