CD4/CD8-negative T cells with alpha beta antigen receptors.
A minor population of alpha beta T cells expresses neither CD4 nor CD8. These cells are probably heterogeneous. They are widespread in anatomical distribution, express an abnormal T-cell repertoire largely unaffected by selective processes that act on CD4+ and CD8+ T cells, and exhibit both cytotoxic and Th-2-like functions. Their role in normal immune function is completely obscure, but they are active in murine and human autoimmune disease.
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Immunobiology Section TE414, Yale University Medical School, New Haven, Connecticut 06510.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D015704:CD4 Antigens; D016827:CD8 Antigens; D006801:Humans; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015704:CD4 Antigens; D016827:CD8 Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta