[Treatment of external ano-genital condylomata with 0.5% podophyllotoxin].
There are several possible protocols for the treatment of ano-genital condylomata. In this study, the efficacy of podophyllotoxin (0.5%) was assessed. The authors observed a recovery rate at 1 month of 81% in cases of condylomata of the balano-preputial and vulvar mucous membranes, a rate of 67% in condylomata of the keratinized tissues and 63% in those of the anal margin. Response to treatment is also dependent on the morphology of the lesion; regression was observed in 78% of cases of condylomata acuminata and in 57% of cases of endophytic condylomata. The side effects were local and consisted of erosion in 20% of cases. The efficacy of treatment was, amongst other things, analysed according to the recurrence of the infection at one month, which occurred in 16% of cases affecting mucous membranes. In the therapeutic arsenal for the treatment of condylomata, podophyllotoxin 0.5% is a first line treatment for condylomata acuminata of the genital mucous membranes.
Aynaud
O
O
Unité d'urologie-andrologie, Hôpital Saint-Jacques, Paris.
Tranbaloc
P
P
D000328:Adult; D001004:Anus Diseases / Q000188:drug therapy* / Q000473:pathology; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010409:Penile Diseases / Q000188:drug therapy* / Q000473:pathology; D011034:Podophyllotoxin / Q000627:therapeutic use*; D011446:Prospective Studies; D012008:Recurrence; D016896:Treatment Outcome; D014845:Vulvar Diseases / Q000188:drug therapy* / Q000473:pathology
D011034:Podophyllotoxin
Traitement des condylomes ano-génitaux externes par podophyllotoxine à 0.5%.