Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo.
Newly synthesized amphiphilic polyacrylamide and poly(vinyl pyrrolidone), single terminus-modified with long-chain fatty acyl groups, are able to incorporate into the liposomal membrane, and similar to poly(ethylene glycol) prolong liposome circulation in vivo and decrease liposome accumulation in the liver. Protective efficacy of modified polymers increases with the increase in the length of acyl moiety and decreases for higher molecular weight polymers. The data on amphiphilic polymer-modified liposome biodistribution are presented.
Torchilin
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VP
Center for Imaging and Pharmaceutical Research, Massachusetts General Hospital-East, Charlestown 02129.
Shtilman
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MI
Trubetskoy
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VS
Whiteman
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K
Milstein
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AM
D000818:Animals; D004337:Drug Carriers; D008081:Liposomes / Q000737:chemistry / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011092:Polyethylene Glycols / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry*; D014018:Tissue Distribution
D004337:Drug Carriers; D008081:Liposomes; D011145:Polyvinyls; D011092:Polyethylene Glycols