A role for a pre-T-cell receptor in T-cell development.
Expression of a productive T-cell receptor (TCR) beta gene has profound consequences for T-cell development, preceding an increase in thymocyte number, appearance of CD4 and CD8 coreceptors and suppression of further TCR beta-gene rearrangement. Here Marcus Groettrup and Harald von Boehmer discuss the data obtained in various experimental models and describe a novel signal transducing receptor complex on pre-T cells, which may regulate the TCR beta-induced developmental changes.
Groettrup
M
M
Basel Institute for Immunology, Switzerland.
von Boehmer
H
H
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013234:Stem Cells / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta