Regulation of heme-regulated eIF-2 alpha kinase and its expression in erythroid cells.
In this article we focus first on the molecular mechanisms controlling the activity of the heme-regulated translational inhibitor, HRI, in erythroid cells. Then we discuss the tissue-specific expression of HRI. The experimental evidence obtained to date indicates that the major physiological role of HRI is in adjusting the synthesis of globin to the availability of heme.
Chen
J J
JJ
Harvard-Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge 02139, USA.
Crosby
J S
JS
London
I M
IM
D000818:Animals; D015672:Erythroid Precursor Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D005914:Globins / Q000096:biosynthesis; D006418:Heme / Q000172:deficiency; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D019892:eIF-2 Kinase
D006418:Heme; D005914:Globins; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase