title: Remote processing, delivery and injection of H2[15O] produced from a N2/H2 gas target using a simple and compact apparatus.
abstract: We report here a simple apparatus for remote trapping and processing of H2[15O] produced from the N2/H2 target. The system performs a three step operation for H2[15O] delivery at the PET imaging facility which includes the following: (i) collecting the radiotracer in sterile water; (ii) adjusting preparation pH through removal of radiolytically produced ammonia, while at the same time adjusting solution isotonicity; and (iii) delivery of the radiotracer preparation to the injection syringe in a sterile and pyrogen-free form suitable for human studies. The processing apparatus is simple, can be remotely operated and fits inside a Capintec Dose Monitoring Chamber for direct measurement of accumulated radioactivity. Using this system, 300 mCi of H2[15O] (15 microA of 8 MeV D+ on target) is transferred from target through 120 m x 3.18 mm o.d. Impolene tubing to yield 100 mCi of H2[15O] which is isotonic, neutral and suitable for human studies. A remote hydraulically driven system for i.v. injection of the H2[15O] is also described. The device allows for direct measurement of syringe dose while filling, and for easy, as well as safe transport of the injection syringe assembly to the patient's bedside via a shielded delivery cart. This cart houses a hydraulic piston that allows the physician to "manually" inject the radiotracer without directly handling the syringe.
authors.affiliation: Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973.
authors.forename: R A
authors.initials: RA
authors.lastname: Ferrieri
authors.forename: D L
authors.initials: DL
authors.lastname: Alexoff
authors.forename: D J
authors.initials: DJ
authors.lastname: Schlyer
authors.forename: A P
authors.initials: AP
authors.lastname: Wolf
mesh_terms: D005740:Gases; D006801:Humans; D006859:Hydrogen; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods; D009584:Nitrogen; D010104:Oxygen Radioisotopes; D014867:Water
chemical_list: D005740:Gases; D010104:Oxygen Radioisotopes; D014867:Water; D006859:Hydrogen; D009584:Nitrogen