Increased serum IgE in schizophrenic patients who responded poorly to neuroleptic treatment.
Total serum IgE and plasma Interleukin (IL)-4 have been determined in patients with schizophrenia, 26 neuroleptic-free, and 81 neuroleptic-treated, and in 46 healthy control subjects. The total serum IgE was significantly higher in the patients who responded poorly to neuroleptic treatment compared with the other four groups (F = 4.27, df = 4, 148, P < 0.003). No significant changes were found in plasma IL-4 levels between any of the five groups. It is possible that raised serum IgE levels may characterise a subgroup of schizophrenia.
Ramchand
R
R
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, University of Wales, United Kingdom.
Wei
J
J
Ramchand
C N
CN
Hemmings
G P
GP
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*
D014150:Antipsychotic Agents; D015415:Biomarkers; D015847:Interleukin-4; D007073:Immunoglobulin E