The nucleotide sequence of the murine Hox-D3 (Hox-4.1) gene reveals extensive identity with the human protein.
We report the sequence of the murine Hox-D3 gene, formerly referred to as Hox-4, Hox-4.1 and Hox-4A. This gene is located on murine chromosome 2 in the Hox-D complex. The predicted Hox-D3 protein comprises 417 amino acids and displays 95% identity to the human protein. We have demonstrated that Hox-D3 is expressed in the skin, kidney and thymus, but not in lung, liver, spleen or stomach.
Brown
W M
WM
Skin Biology Research Center of Johnson & Johnson, R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869.
Zhou
L
L
Taylor
G R
GR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics*; D005801:Genes, Homeobox / Q000235:genetics*; D015698:Genomic Library; D018398:Homeodomain Proteins; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C489520:Hoxd4 protein, mouse; D012333:RNA, Messenger; D014157:Transcription Factors; C072064:HOXD10 protein, human