title: Early analysis of viremia and clinical tests in patients with epidemic hemorrhagic fever.
abstract: We analysed the early viremia and clinical tests in 82 patients with epidemic hemorrhagic fever (EHF). The results showed that the changes in viremia and clinical tests are related to the severity of the disease and prognosis. Higher concentrations of the virus in infected patients might cause a more unfavourable prognosis and more abnormalities in clinical tests. CK-MB, SGOT, SGPT, serum creatinine and urea nitrogen contents increased markedly, while serum total protein, albumin and calcium contents decreased markedly, indicating that the heart, liver and kidney in EHF patients were severely damaged. Markedly increased WBC and monocytes showed that the patients were seriously infected. Platelet count, antithrombin-III and plasminogen decreased markedly, demonstrating that there were marked changes in the coagulation-anticoagulation and fibrinolytic system of the EHF patients. Changes in RBC, Hb and HCT contents indicated that the blood in the EHF patients had a higher concentration. This study gives further evidence that EHFV plays an important role in the pathogenesis of EHF.
authors.affiliation: Virus Research Institute, Hubei Medical College, Wuhan.
authors.forename: T M
authors.initials: TM
authors.lastname: Zhang
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Yang
authors.forename: M Y
authors.initials: MY
authors.lastname: Zhang
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Hu
authors.forename: J M
authors.initials: JM
authors.lastname: Xiang
authors.forename: J W
authors.initials: JW
authors.lastname: Huggins
authors.forename: T M
authors.initials: TM
authors.lastname: Cosgriff
authors.forename: J I
authors.initials: JI
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006400:Hematocrit; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000382:microbiology*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014766:Viremia / Q000097:blood*
chemical_list: D007527:Isoenzymes; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase