title: Long-term stability studies on the WHO IRP for thromboplastin (human plain BCT/253).
abstract: Long-term stability studies on the WHO second primary International Reference Preparation (IRP) for thromboplastin (human plain BCT/253) stored at -20 degrees C have been conducted for ten years. Three centres took part in the exercise using frozen normal and coumarinised plasma samples which were tested throughout. There has been no measurable change in the prothrombin time performance of the human plain IRP over the ten-year period. It can therefore be concluded that new IRP may continue to be calibrated against this preparation in accord with WHO recommendations.
authors.affiliation: UK Reference Laboratory for Anticoagulant Reagents and Control, Withington Hospital, Manchester.
authors.forename: L
authors.initials: L
authors.lastname: Poller
authors.forename: J
authors.initials: J
authors.lastname: Pulford
authors.forename: K J
authors.initials: KJ
authors.lastname: Stevenson
authors.forename: P
authors.initials: P
authors.lastname: Cooper
authors.forename: G
authors.initials: G
authors.lastname: Gamble
authors.forename: J M
authors.initials: JM
authors.lastname: Thomson
mesh_terms: D000704:Analysis of Variance; D002138:Calibration; D004355:Drug Stability; D006801:Humans; D011517:Prothrombin Time; D012015:Reference Standards; D013925:Thromboplastin / Q000737:chemistry*; D014944:World Health Organization
chemical_list: D013925:Thromboplastin