Solubility of organic solutes in ethanol/water mixtures.
The log-linear solubilization model was applied to the experimental solubility data of 109 organic compounds in ethanol/water mixtures. It is found that the extent of solubilization strongly depends on the solute hydrophobicity and the ethanol concentration in the solvent mixture. Patterns of deviation from the log-linear model are related to the structure and hydrophobicity of the solutes. Predictive equations were obtained by regression of the experimental data with solute octanol/water partition coefficient (log Kow). The logarithms of the solubilization and the solute log Kow range over 11 orders of magnitude. The solubilities of chrysene, perylene, benzo[a]pyrene, pentachlorobenzene, and hexachlorobenzene in ethanol/water mixtures were experimentally determined, and the results fit well into the model.
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Department of Pharmaceutical Practice, University of Arizona, Tucson 85721.
Yalkowsky
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D055598:Chemical Phenomena; D002627:Chemistry, Physical; D000431:Ethanol / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry*; D007700:Kinetics; D012995:Solubility; D014867:Water / Q000737:chemistry*
D006838:Hydrocarbons; D014867:Water; D000431:Ethanol