HIV infection in recipients of blood products from donors with known duration of infection.
From a registry of people with transfusion-acquired HIV infection, 25 recipients were identified for whom the dates of HIV infection in the 8 corresponding donors could be established. Longer times to AIDS and to death in recipients were independently associated (p < 0.01) with the receipt of blood from donors who developed AIDS more than 10 years after HIV infection, as well as with older age and fewer transfusions. Sex, zidovudine treatment, and severity of illness at transfusion were not significantly associated with survival.
Ashton
L J
LJ
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia.
Learmont
J
J
Luo
K
K
Wylie
B
B
Stewart
G
G
Kaldor
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D016913:Blood Component Transfusion / Q000009:adverse effects*; D001782:Blood Donors; D017848:Blood-Borne Pathogens; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology / Q000635:transmission*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016019:Survival Analysis; D013997:Time Factors; D015215:Zidovudine / Q000627:therapeutic use
D015215:Zidovudine