Increase in the chemically-induced differentiation of human leukemia cell lines by tubulin disruptors.
The effect of various structural/functional tubulin disruptors (including colchicine-type disruptors, vinblastine, rhizoxin, maytansine, peptide-type disruptors, and taxol) on the chemically induced differentiation of human leukemia cell lines (HL-60 and K562) was examined. As differentiation-inducing agents, 12-O-tetradecanoylphorbol-13-acetate (TPA) was used for the differentiation of both HL-60 and K562 to monocyte/macrophages, retinoids were used for the differentiation of HL-60 to mature granulocytes, and hemin was used for the erythroid differentiation of K562. All the tubulin disruptors investigated increased the chemically-induced differentiation of HL-60 and K562 cell lines to the cognate mature cell types, regardless of the nature of the differentiation.
Nakajima
O
O
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Sugishita
Y
Y
Hashimoto
Y
Y
Iwasaki
S
S
D002454:Cell Differentiation; D003078:Colchicine / Q000494:pharmacology; D006427:Hemin / Q000494:pharmacology; D006801:Humans; D007942:Leukemia, Experimental / Q000503:physiopathology*; D012176:Retinoids / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014404:Tubulin / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D012176:Retinoids; D014404:Tubulin; D006427:Hemin; D013755:Tetradecanoylphorbol Acetate; D003078:Colchicine