Corticosteroids and growth.
In summary, corticosteroids suppress linear growth. The growth suppression is mediated by perturbations in growth factors as evidenced by: (1) abnormal spontaneous GH secretion and a blunted response to provocative stimuli and (2) decreased local production of IGF-I. Corticosteroids suppress GH responses by altering somatostatin tone. In addition, corticosteroids are anti-anabolic with resultant protein wasting. Exogenous administration of rhGH is effective in reversing all the clinical catabolic effects of corticosteroids. The duel factors of corticosteroids and uremia which are growth suppressive can be overcome by exogenous rhGH administration.
Fine
R N
RN
Department of Pediatrics, Childrens Medical Center, State University of New York at Stony Brook.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000097:blood / Q000494:pharmacology; D013007:Growth Hormone-Releasing Hormone / Q000097:blood; D006801:Humans; D016030:Kidney Transplantation; D011994:Recombinant Proteins; D013002:Somatomedins / Q000378:metabolism; D013004:Somatostatin / Q000097:blood; D014184:Transplantation, Homologous; D014511:Uremia / Q000188:drug therapy
D000305:Adrenal Cortex Hormones; D011994:Recombinant Proteins; D013002:Somatomedins; D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone