The effect of dapiprazole on accommodative amplitude in eyes dilated with 0.5 percent tropicamide.
BACKGROUND
Dapiprazole 0.5 percent (REV-EYES) eyedrops have recently become commercially available in the U.S. to reverse the diagnostic mydriasis produced by various concentrations and combinations of tropicamide and phenylephrine. Although a previous study has shown that dapiprazole increased accommodative amplitude after the administration of tropicamide, no attempt was made to control for differences in pupil size.


METHODS
In the present single masked study, the accommodative amplitudes of forty-eight age-matched subjects previously dilated with 0.5% tropicamide were measured through a 3 millimeter artificial pupil following random instillation of dapiprazole in one eye and a placebo drop in the other eye.


RESULTS
Area under the curve analysis determined that the magnitude of accommodative response to dapiprazole was significant at p < 0.001 (paired t-test). The McNemar test also showed that the accommodative amplitude was greater in eyes treated with dapiprazole at all observation points (p < 0.005), beginning at 15 mins after the instillation of the test drug.


CONCLUSIONS
The results demonstrate that dapiprazole accelerates the return of accommodation independent of pupil size.
Nyman
N
N
Pennsylvania College of Optometry, Philadelphia 19141.
Reich
L
L
D000065:Accommodation, Ocular / Q000187:drug effects*; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D004311:Double-Blind Method; D005127:Eye Color / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D010879:Piperazines; D011680:Pupil / Q000187:drug effects*; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology*; D014331:Tropicamide / Q000008:administration & dosage*
D000317:Adrenergic alpha-Antagonists; D009883:Ophthalmic Solutions; D010879:Piperazines; D014230:Triazoles; C035289:dapiprazole; D014331:Tropicamide