Dopamine blocks T-type calcium channels in cultured rat adrenal glomerulosa cells.
Dopamine is known to inhibit aldosterone secretion. In the present study using whole-cell voltage-clamp technique we found that dopamine, bromocriptine and quinpirole inhibit low-threshold (T-type) voltage dependent Ca2+ channels. The inhibiton was sustained and reversible, and it was prevented by sulpiride. These findings indicate that the effect of dopamine was mediated via DA2 receptors.
Osipenko
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ON
Department of Pharmacology, Hungarian Academy of Sciences, Budapest.
Várnai
P
P
Mike
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A
Spät
A
A
Vizi
E S
ES
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D004298:Dopamine / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology; D004563:Electrochemistry; D004594:Electrophysiology; D051381:Rats; D017208:Rats, Wistar; D015384:Zona Glomerulosa / Q000166:cytology / Q000378:metabolism*
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D015259:Dopamine Agents; D004298:Dopamine