Identification of a new DNA polymorphism tightly linked to DQ-alpha locus.
Utilizing Alu-polymerase chain reaction and single-strand conformation polymorphism technologies a new DNA restriction fragment length polymorphism was detected on a cosmid clone located on chromosome 6p21. An accurate analysis of allele frequency was carried out on a large series of unrelated individuals. Furthermore a detailed linkage analysis in several large pedigrees showed this new polymorphism to be tightly linked to the HLA-DQ alpha locus.
Gasparini
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P
Servizio di Genetica Medica, IRCCS, Ospedale CSS, San Giovanni Rotondo, Italia.
Bonizzato
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A
Totaro
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A
Zelante
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L
D001483:Base Sequence; D002896:Chromosomes, Human, Pair 6; D008040:Genetic Linkage; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010375:Pedigree; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D006683:HLA-DQ Antigens