[The pharmacodynamics of proxodolol when administered once and in a course of doses to patients with stenocardia of effort].
The effects of placebo and proxodolol, a new hybrid (beta-, alpha-) adrenoblocking agent, on exercise tolerance, hemodynamics and the conduction system were compared in 28 patients with coronary heart disease, Functional Class II-III exercise-induced angina pectoris at rest and during bicycle ergometric exercise test. Proxodolol was shown to exert a significant dose-dependent antianginal effect without producing any negative effect on atrioventricular and intraventricular conduction.
Petrov
I N
IN
Rumiantsev
A S
AS
Smirnov
M V
MV
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010069:Oxadiazoles / Q000008:administration & dosage / Q000494:pharmacology*; D005082:Physical Exertion / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D010069:Oxadiazoles; C088649:proxodolol
Farmakodinamika proksodolola pri odnokratnom i kursovom naznachenii bol'nym stenokardieĭ napriazheniia.