NAD glycohydrolases: a possible function in calcium homeostasis.
NAD glycohydrolases are the longest known enzymes that catalyze ADP-ribose transfer. The function of these ubiquitous, membrane-bound enzymes has been a long standing puzzle. The NAD glycohydrolases are briefly reviewed in light of the discovery by our laboratory that NAD glycohydrolases are bifunctional enzymes that can catalyze both the synthesis and hydrolysis of cyclic ADP-ribose, a putative second messenger of calcium homeostasis.
Kim
H
H
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 76017.
Jacobson
E L
EL
Jacobson
M K
MK
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D015394:Molecular Structure; D009244:NAD+ Nucleosidase / Q000502:physiology*
D009244:NAD+ Nucleosidase; D002118:Calcium