Serum levels of intercellular adhesion molecule-1 in patients with alcoholic liver disease.
Serum levels of intercellular adhesion molecule-1 (ICAM-1) were measured in 37 patients with alcoholic liver disease, six alcoholics without liver disease and ten healthy subjects. The serum level of ICAM-1 was significantly higher in the patients with alcoholic cirrhosis than in the noncirrhotic alcoholic liver disease patients (P < 0.005) and the healthy subjects (P < 0.001). Furthermore, the serum level of ICAM-1 was significantly higher in the patients with alcoholic hepatitis than in those with alcoholic cirrhosis (P < 0.001). No significant difference in serum ICAM-1 levels was found between normal subjects and alcoholics without liver diseases. In the patients with alcoholic hepatitis, serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) derived from macrophages were increased in the presence of endotoxemia. The increase in serum ICAM-1 may therefore be related to the strong expression of ICAM-1 of hepatocytes and endothelial cells accompanied by the increase in serum TNF-alpha.
Shimada
S
S
First Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Yamauchi
M
M
Toda
G
G
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006519:Hepatitis, Alcoholic / Q000097:blood / Q000175:diagnosis; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000175:diagnosis; D008108:Liver Diseases, Alcoholic / Q000097:blood / Q000175:diagnosis*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1