Reduced streptozotocin-induced insulitis in CD-1 mice by treatment with anti-intercellular adhesion molecule-1 and anti-lymphocyte function associated antigen-1 monoclonal antibodies together with lactic dehydrogenase virus infection.
Multiple low-dose streptozotocin (SZ)-induced insulitis is an animal model for insulin-dependent diabetes mellitus characterized by a mononuclear cell infiltration. SZ-induced insulitis and blood glucose concentrations were reduced by treatment with anti-intercellular adhesion molecule-1(ICAM-1) and anti-lymphocyte function associated antigen-1 (LFA-1) monoclonal antibodies. This suppressing effect was also seen in mice infected with lactic dehydrogenase virus (LDV). These results suggest that the expression of ICAM-1 in islets and LFA-1 on mononuclear cells may be important in the development of SZ-induced insulitis. The suppressive effect of LDV infection on the development of insulitis is discussed.
Hayashi
T
T
Laboratory of Veterinary Pathology, Yamaguchi University, Japan.
Hashimoto
S
S
Kameyama
Y
Y
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D018174:Arterivirus Infections / Q000276:immunology* / Q000473:pathology; D001786:Blood Glucose / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000276:immunology*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D018799:Intercellular Adhesion Molecule-1; D007515:Islets of Langerhans / Q000473:pathology; D007772:Lactate dehydrogenase-elevating virus; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
D000911:Antibodies, Monoclonal; D001786:Blood Glucose; D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1