[Hypothalamic mechanisms of neurohormone regulation of the endocrine part of the pancreas].
Hyperglycemia, hypoinsulinemia, and an increase of glucagon and somatostatin concentration under diabetes mellitus are accompanied by intensification of secretion of hypothalamic neurohormones (CRF, vasopressin, oxytocin, somatostatin) with the corresponding signs of the increase in activity of hypothalamus nuclei and subnuclei secreting them as well as ACTH, corticosterone and cortisol rise in blood. Adaptation to hypoxia has caused hypoglycemia, activated insulin biosynthesis, changed glucagon and somatostatin synthesis and secretion. CRF corticosterone, cortisol and ACTH concentration in blood was not changed, vasopressin concentration lowered, somatostatin and oxytocin amount (in hypothalamus) increased to a higher degree than under diabetes. Adaptation to hypoxia corrected impaired hormone balance and state of Langerhans islets (beta-cells destruction process inhibition, insulin biosynthesis stimulation, glucagon and somatostatin secretion decrease) under diabetes mellitus, hypothalamus neurohormones participating in this process.
Kolesnyk
Iu M
IuM
Abramov
A V
AV
D000222:Adaptation, Physiological; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005934:Glucagon / Q000378:metabolism; D006728:Hormones / Q000502:physiology*; D007003:Hypoglycemia / Q000209:etiology / Q000503:physiopathology; D007031:Hypothalamus / Q000503:physiopathology*; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology*; D007515:Islets of Langerhans / Q000503:physiopathology*; D010121:Oxytocin / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism / Q000502:physiology; D014667:Vasopressins / Q000502:physiology
D006728:Hormones; D014667:Vasopressins; D010121:Oxytocin; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D005934:Glucagon; D003346:Corticotropin-Releasing Hormone
Hipotaliamichni mekhanizmy neĭrohormonal'noï rehuliatsiï stanu endokrynnoĭ chastyny pidshlunkovoï zolozy.