title: Pulmonary failure following lower torso ischemia: clinical evidence for a remote effect of reperfusion injury.
abstract: Acute lung injury as a remote sequela of severe lower torso ischemia-reperfusion has been demonstrated experimentally, in a process involving leukosequestration and generation of the arachidonate derivatives thromboxane and leukotriene B4. However, contemporary clinical reports have been limited to development of transient, subclinical "reperfusion pulmonary edema" several hours after declamping in patients undergoing elective abdominal aortic aneurysm repair. This report refocuses attention on the clinical syndrome of severe, acute deterioration in pulmonary function occurring several hours after restoration of perfusion to an ischemic lower torso in two patients. The lung injury is characterized by progressive hypoxemia, pulmonary hypertension, decreased lung compliance, and non-hydrostatic pulmonary edema, consistent with adult respiratory distress syndrome (ARDS). This report reinforces the concept that humoral mediators generated at reflow may induce end-organ injury at a site remote from the focus of ischemia-reperfusion, and that the lung is a target organ.
authors.affiliation: Department of Surgery, New York Hospital, NY 10021.
authors.forename: G A
authors.initials: GA
authors.lastname: Fantini
authors.forename: M S
authors.initials: MS
authors.lastname: Conte
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications*; D007866:Leg / Q000098:blood supply*; D008171:Lung Diseases / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications; D015427:Reperfusion Injury / Q000150:complications* / Q000503:physiopathology