[DNA typing of allelic variants of HLA-B27: HLA-B*2705 is the predominant allele of the aboriginal population of the Chukot peninsula (Eskimos and Chukchi)].
The purpose of the study was to estimate the relative frequency of the known HLA-B27 subtypes among HLA-B27 positive Chukot natives. Using oligotyping of the polymerase chain reaction amplified second and third exons of the HLA-B27 gene in 86 DNA samples from HLA-27 positive individuals were success-fully typed. All had HLA-B*2705, including nine patients with ankylosing spondylitis and Reiter's syndrome, except for one Eskimo who had HLA-B*2702. None had HLA-B*2704, a frequent subtype in Orientals. Considering the HLA-B27 subtypes, the Chukot population groups are genetically more closely related to Caucasians than to Orientals.
Krylov
M Iu
MIu
Alekseeva
L I
LI
Erdes
Sh
Sh
Benevolenskaia
L I
LI
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D005091:Exons; D005828:Genetics, Population; D005838:Genotype; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D004930:Inuit / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012800:Siberia
D017931:DNA Primers; D015796:HLA-B27 Antigen
DNK-tipirovanie allel'nykh variantov HLA-B27: HLA-B*2705 iavliaetsia preobladaiushchim allelem sredi korennogo naseleniia chukotki (éskimosov i chukcheĭ).