Elevated serum calprotectin levels in HIV-infected patients: the calprotectin response during ZDV treatment is associated with clinical events.
The calcium-binding myelomonocytic protein calprotectin (L1 protein) was quantified in serum from 51 patients with HIV infection and in 20 HIV-seronegative blood donors. Significantly elevated levels were found both in asymptomatic patients and in people with AIDS compared with controls. The calprotectin level was not related to ongoing or recent opportunistic infections. For patients with CD4+ counts above 50 x 10(6)/L, a significant negative correlation was found between serum calprotectin levels and the CD4+ counts. Serial samples from 24 patients during their first year of zidovudine (ZDV) treatment showed a further elevation of serum calprotectin during the first months of ZDV treatment, with a subsequent decline to pretreatment levels. A low calprotectin response during the first 6 months, determined as area under the curve, was associated with the occurrence of at least one AIDS-defining infection during the first year of antiviral treatment. Also, a low calprotectin maximal response during ZDV therapy was associated with short survival. Similar associations were not found for neopterin, beta 2-microglobulin, HIV p24 antigen, or CD4+ or CD8+ lymphocytes in blood. Our findings in a limited number of patients suggest that calprotectin levels may reflect immune activation and other immune mechanisms correlated with enhanced antimicrobial defense induced at least transiently by antiviral treatment.
Müller
F
F
Kaptein W. Wilhelmsen og Frues Institute of Bacteriology, University of Oslo, National Hospital, Rikshospitalet, Norway.
Frøland
S S
SS
Aukrust
P
P
Fagerhol
M K
MK
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000954:Antigens, Surface / Q000097:blood; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D015496:CD4-Positive T-Lymphocytes; D002135:Calcium-Binding Proteins / Q000097:blood*; D015816:Cell Adhesion Molecules, Neuronal / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy / Q000401:mortality; D006801:Humans; D007958:Leukocyte Count; D039841:Leukocyte L1 Antigen Complex; D008297:Male; D019798:Neopterin; D011379:Prognosis; D016019:Survival Analysis; D050378:T-Lymphocytes, Regulatory; D013997:Time Factors; D015215:Zidovudine / Q000627:therapeutic use*; D001613:beta 2-Microglobulin / Q000032:analysis
D000954:Antigens, Surface; D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal; D016655:HIV Core Protein p24; D039841:Leukocyte L1 Antigen Complex; D001613:beta 2-Microglobulin; D001708:Biopterins; D015215:Zidovudine; D019798:Neopterin