Human hematolymphoid cells in SCID mice.
The severe combined immunodeficient C.B.-17 scid/scid (SCID) mouse has been widely used to study the normal processes of murine lymphoid differentiation. To create an in vivo model of the human hematolymphoid system, this mouse strain has been engrafted with human organ systems (the SCID-hu mouse) or with human peripheral blood mononuclear cells (the hu-PBL-SCID mouse). These mouse models have now been characterized and used to analyze human infectious diseases, hematopoiesis, malignancies and vaccines.
Kaneshima
H
H
New Enterprise Research Division, SyStemix Inc, Palo Alto, California 94304.
Namikawa
R
R
McCune
J M
JM
D000818:Animals; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008221:Lymphoid Tissue / Q000637:transplantation*; D051379:Mice; D016513:Mice, SCID / Q000502:physiology*; D018183:Transplantation Chimera / Q000502:physiology*