title: Percentage of proliferating cell nuclear antigen (PCNA)-positive Reed-Sternberg cells in nodular sclerosis Hodgkin's disease.
abstract: Proliferating cell nuclear antigen (PCNA/cyclin) is a useful marker of proliferation and its expression correlates with prognosis in some human neoplasms. The clinical course of nodular sclerosis Hodgkin's disease (NSHD) varies in both grades (NSI, NSII) as defined by the British National Lymphoma Investigation. Expression of PCNA in Reed-Sternberg cells and their variants was evaluated in NSI and NSII. There were no significant differences in the ratio of PCNA-positive cells in both groups. The results suggest that differences in the clinical course do not depend on the proliferative rate of Reed-Sternberg cells and their variants in NSHD.
authors.affiliation: Department of Oncology, Medical Academy, Lódź.
authors.forename: R
authors.initials: R
authors.lastname: Kordek
authors.forename: W
authors.initials: W
authors.lastname: Biernat
authors.forename: H
authors.initials: H
authors.lastname: Niewiadomska
authors.forename: D
authors.initials: D
authors.lastname: Kupnicka
authors.forename: L
authors.initials: L
authors.lastname: Woźniak
authors.forename: W
authors.initials: W
authors.lastname: Domagała
authors.forename: M
authors.initials: M
authors.lastname: Osborn
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D006689:Hodgkin Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen; D016539:Reed-Sternberg Cells / Q000276:immunology* / Q000473:pathology; D012598:Sclerosis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen