title: Proenkephalin and prodynorphin mRNA level in brain of rats with absence epilepsy.
abstract: An in situ hybridization method was used to estimate the proenkephalin (PENK) and prodynorphin (PDYN) mRNA levels in the brain of epileptic 6-month-old WAG/Rij rats in comparison with non-epileptic: 3-month-old WAG/Rij rats, 3-month-old ACI rats and 6-month-old ACI rats. The epileptic rats had a significantly higher level of PENK mRNA in the striatum as compared to non-epileptic controls. The PDYN mRNA level was significantly elevated only in the hippocampus of epileptic rats, whereas age- or strain-related changes in the striatal and cortical PDYN mRNA levels were found in both epileptic and non-epileptic rats. The changes in the biosynthetic activity of endogenous opioid peptide systems may be important for the occurrence of epileptic discharges in these animals.
authors.affiliation: Neuropeptide Research Department, Polish Academy of Sciences, Kraków.
authors.forename: W
authors.initials: W
authors.lastname: Lasoń
authors.forename: B
authors.initials: B
authors.lastname: Przewłocka
authors.forename: G
authors.initials: G
authors.lastname: Van Luijtelaar
authors.forename: A
authors.initials: A
authors.lastname: Coenen
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D004745:Enkephalins / Q000235:genetics*; D004832:Epilepsy, Absence / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D017403:In Situ Hybridization; D008297:Male; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats
chemical_list: D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; C029992:proenkephalin; C033660:preproenkephalin