Molecular approaches to the diagnosis and treatment of cancer.
We have used autologous bone marrow transplantation (ABMT) as a setting to develop the genetic therapy of cancer in hematopoietic neoplasms based on the use of the bone marrow as a conduit through which to introduce regulatory molecules into the patient. This has involved three developmental phases: 1) learning how to develop genetic modification techniques; 2) learning how to develop in vivo selection techniques for the genetically modified cells; and 3) developing molecular vectors for modification of hematopoietic cells for therapy of cancer. These programs will be summarized in terms of their progress at the conference.
Deisseroth
A B
AB
Department of Hematology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Kantarjian
H
H
Talpaz
M
M
Champlin
R
R
Reading
C
C
Hanania
E G
EG
Fu
S
S
Randhawa
G S
GS
Cha
Y
Y
Fang
X
X
D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*