title: Phase II trial of piroxantrone in metastatic gastric adenocarcinoma.
abstract: Piroxantrone, a synthetic intercalating agent, was studied in patients with advanced, measurable gastric adenocarcinoma who had not received prior chemotherapy. The starting piroxantrone dose was 150 mg/m2 given intravenously over 1 hour on day 1 and repeated every 21 days. Response and toxicity could be evaluated in 15 patients. No complete, partial, or minor responses were observed. Toxic effects included granulocytopenia, anemia, vomiting, nausea, anorexia, fatigue, stomatitis, alopecia, hyperbilirubinemia, and increased alkaline phosphatase levels. At the stated dose and schedule, piroxantrone does not possess significant activity against advanced gastric cancer.
authors.affiliation: Division of Medicine, University of Texas M. D. Anderson Cancer Center, Houston.
authors.forename: R
authors.initials: R
authors.lastname: Pazdur
authors.forename: B
authors.initials: B
authors.lastname: Bready
authors.forename: A J
authors.initials: AJ
authors.lastname: Scalzo
authors.forename: J E
authors.initials: JE
authors.lastname: Brandof
authors.forename: D R
authors.initials: DR
authors.lastname: Close
authors.forename: S
authors.initials: S
authors.lastname: Kolbye
authors.forename: R J
authors.initials: RJ
authors.lastname: Winn
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000139:chemically induced; D000880:Anthraquinones / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D011720:Pyrazoles; C046659:piroxantrone