title: [Serotonin antibodies and their possible role in parkinsonism].
abstract: Serotonin antibodies (SAb) were found in the blood sera of middle-aged and elderly parkinsonian patients. The incidence of Sab in young and middle-aged healthy subjects was less, but increasing with age. Injected into the rabbit caudate nuclei, Sab suppressed the main pathogenetic mechanism of parkinsonian syndrome, the generator of pathologically enhanced excitation (GPEE) and parkinsonian symptoms induced by the MPP injection into substantia nigra. The intracaudate injection of serotonin enhanced GPEE activity and parkinsonian syndrome. The role of serotoninergic system and Sab in parkinsonism is discussed.
authors.forename: G N
authors.initials: GN
authors.lastname: Kryzhanovskiĭ
authors.forename: N B
authors.initials: NB
authors.lastname: Man'kovskiĭ
authors.forename: I N
authors.initials: IN
authors.lastname: Karaban'
authors.forename: S V
authors.initials: SV
authors.lastname: Magaeva
authors.forename: N A
authors.initials: NA
authors.lastname: Trekova
authors.forename: L A
authors.initials: LA
authors.lastname: Vetrilé
authors.forename: L A
authors.initials: LA
authors.lastname: Basharova
authors.forename: M A
authors.initials: MA
authors.lastname: Atadzhanov
authors.forename: K M
authors.initials: KM
authors.lastname: Golubev
mesh_terms: D015655:1-Methyl-4-phenylpyridinium / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000097:blood*; D000918:Antibody Specificity; D002421:Caudate Nucleus / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology; D016000:Cluster Analysis; D004195:Disease Models, Animal; D004594:Electrophysiology; D006801:Humans; D007114:Immunization; D008875:Middle Aged; D010300:Parkinson Disease / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D011817:Rabbits; D012701:Serotonin / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000906:Antibodies; D012701:Serotonin; D015655:1-Methyl-4-phenylpyridinium
vernacular_title: Antitela k serotoninu i ikh vozmozhnaia rol' pri parkinsonizme.