title: Congenital rubella syndrome despite repeated vaccination of the mother: a coincidence of vaccine failure with failure to vaccinate.
abstract: Congenital rubella syndrome occurred in a boy born to a mother who had been properly vaccinated three times before conception, but developed only low titers of rubella antibody. The non-vaccinated father most likely infected the mother on a home visit during the third to fifth weeks of gestation. He served in the army and fell ill during an outbreak of a rubella-like disease in his military unit. The mother subsequently developed a slight rash, but rubella IgM antibodies were lacking and rubella infection was not suspected. This incidence demonstrates the necessity of vaccinating all children, including boys and young men, in order to reduce the number of infections and prevent further cases of congenital rubella syndrome.
authors.affiliation: Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene der Universität Freiburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Braun
authors.forename: D
authors.initials: D
authors.lastname: Kampa
authors.forename: R
authors.initials: R
authors.lastname: Fressle
authors.forename: E
authors.initials: E
authors.lastname: Willke
authors.forename: M
authors.initials: M
authors.lastname: Stahl
authors.forename: O
authors.initials: O
authors.lastname: Haller
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D018562:Disease Transmission, Infectious; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000517:prevention & control*; D012409:Rubella / Q000635:transmission; D012410:Rubella Syndrome, Congenital / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000276:immunology; D012412:Rubella virus / Q000276:immunology; D018454:Spouses; D017211:Treatment Failure; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D012411:Rubella Vaccine