Three cases of alopecia areata induced by zotepine.
One schizophrenic and two manic-depressive patients who after the administration of zotepine, a new antipsychotic and antimanic drug, developed alopecia areata, a kind of autoimmune disease, are reported. They recovered following the discontinuation or decrease in the dose of zotepine. These three cases of alopecia areata suggest that the antipsychotic drugs may induce autoimmune disease through their neuropsychological effect.
Kubota
T
T
Department of Neuropsychiatry, Kohritsu Mattoh Ishikawa Central Hospital, Mattoh, Japan.
Ishikura
T
T
Jibiki
I
I
D000328:Adult; D000505:Alopecia / Q000139:chemically induced / Q000175:diagnosis; D000506:Alopecia Areata / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D002220:Carbamazepine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002997:Clomipramine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D003937:Diagnosis, Differential; D003988:Dibenzothiepins / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D002220:Carbamazepine; D006220:Haloperidol; D002997:Clomipramine; C022172:zotepine