[Function of the hypothalamus-thyroid system long after radiation and neurotropin correction of the disorders detected].
In experiments on Wistar male rats exposed to single X-ray radiation 0.5 Gy and combination of X-ray 0.5 Gy and 131I 6.5 microCi/kg inhibition of activity of excitatory and inhibitory neurotransmitter processes in the mediobasal hypothalamus was observed 6 months after radiation. This was accompanied by a prolonged hypofunction of the thyroid gland related to disorders with glandular stromal follicles and secretion of hormones into the bloodstream. Application of neurotropin that normalizes to a certain extent the transmitter relationship in the hypothalamus does not act positively on the thyroid functional activity. All this indicates a necessity of combined correction of the disorders found not only with neurotropic drugs but also with directional therapy of the affected organs and systems.
Gurin
V N
VN
Institute of Bioactive Science, Nipon Zoki, Osaka, Japan.
Dudina
T V
TV
Elkina
A I
AI
Kandybo
T S
TS
Konishi
Zh E
ZhE
D000818:Animals; D003131:Combined Modality Therapy; D007027:Hypothalamic Diseases / Q000503:physiopathology / Q000628:therapy*; D007031:Hypothalamus / Q000187:drug effects / Q000503:physiopathology* / Q000528:radiation effects; D008297:Male; D018377:Neurotransmitter Agents / Q000502:physiology*; D011134:Polysaccharides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013959:Thyroid Diseases / Q000503:physiopathology / Q000628:therapy*; D013961:Thyroid Gland / Q000187:drug effects / Q000503:physiopathology* / Q000528:radiation effects; D013963:Thyroid Hormones / Q000378:metabolism; D013997:Time Factors
D018377:Neurotransmitter Agents; D011134:Polysaccharides; D013963:Thyroid Hormones; C010491:neurotropin
Funktsiia sistemy gipotalamus-shchitovidnaia zheleza v otdalennye sroki posle oblucheniia i korrektsiia vyiavlennykh narusheniĭ neĭrotropinom.