title: Spectrum of activity of soluble intercellular adhesion molecule-1 against rhinovirus reference strains and field isolates.
abstract: The antiviral potency of soluble intercellular adhesion molecule-1 (ICAM-1; the major receptor for human rhinoviruses) was determined for a subset of American Type Culture Collection reference serotypes and field isolates of rhinovirus. The results indicate that soluble ICAM-1 exhibits a broad spectrum of activity against rhinoviruses and that field isolates have a sensitivity indistinguishable from that of laboratory strains.
authors.affiliation: Institute for Inflammation and Experimental Medicine, Miles Biotechnology, West Haven, Connecticut 06516.
authors.forename: A
authors.initials: A
authors.lastname: Ohlin
authors.forename: H
authors.initials: H
authors.lastname: Hoover-Litty
authors.forename: G
authors.initials: G
authors.lastname: Sanderson
authors.forename: A
authors.initials: A
authors.lastname: Paessens
authors.forename: S L
authors.initials: SL
authors.lastname: Johnston
authors.forename: S T
authors.initials: ST
authors.lastname: Holgate
authors.forename: E
authors.initials: E
authors.lastname: Huguenel
authors.forename: J M
authors.initials: JM
authors.lastname: Greve
mesh_terms: D015815:Cell Adhesion Molecules / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D008826:Microbial Sensitivity Tests; D011994:Recombinant Proteins / Q000494:pharmacology; D012229:Rhinovirus / Q000187:drug effects*
chemical_list: D015815:Cell Adhesion Molecules; D011994:Recombinant Proteins; D018799:Intercellular Adhesion Molecule-1