title: New bioactive taxoids from cell cultures of Taxus baccata.
abstract: Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-O-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named taxcultine [4], contained an n-propyl group on the side-chain. All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen.
authors.affiliation: PHYTOpharmaceuticals, Inc., San Carlos, California 94070.
authors.forename: W
authors.initials: W
authors.lastname: Ma
authors.forename: G L
authors.initials: GL
authors.lastname: Park
authors.forename: G A
authors.initials: GA
authors.lastname: Gomez
authors.forename: M H
authors.initials: MH
authors.lastname: Nieder
authors.forename: T L
authors.initials: TL
authors.lastname: Adams
authors.forename: J S
authors.initials: JS
authors.lastname: Aynsley
authors.forename: O P
authors.initials: OP
authors.lastname: Sahai
authors.forename: R J
authors.initials: RJ
authors.lastname: Smith
authors.forename: R W
authors.initials: RW
authors.lastname: Stahlhut
authors.forename: P J
authors.initials: PJ
authors.lastname: Hylands
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002140:California; D002478:Cells, Cultured; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008970:Molecular Weight; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014404:Tubulin / Q000096:biosynthesis
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014404:Tubulin; D017239:Paclitaxel