Chronic feeding of carbonyl-iron and TMH-ferrocene in rats. Comparison of two iron-overload models with different iron absorption.
1. The use of carbonyl-iron and (3,5,5-trimethylhexanoyl)-ferrocene (TMH-ferrocene) as a dietary iron-overload model was studied in rats using 59Fe-labelled compounds. 2. The intestinal absorption of carbonyl-iron but not from the TMH-ferrocene-iron was dependent upon the dosage and downregulated in iron-loaded rats. 3. In both models, and similar to hereditary haemochromatosis in humans, the storage of excess iron in the liver started in hepatocytes, whereas the range of iron-loading was strikingly different. 4. Because of the fast and progressive iron-loading, the TMH-ferrocene-model is the most encouraging animal model for experimental haemochromatosis.
Nielsen
P
P
Abteilung Medizinische Biochemie, Physiologisch-Chemisches Institut, Hamburg, Germany.
Heinelt
S
S
Düllmann
J
J
D000284:Administration, Oral; D000818:Animals; D004032:Diet; D004334:Drug Administration Schedule; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000378:metabolism*; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D054354:Iron Carbonyl Compounds; D007504:Iron Radioisotopes; D008099:Liver / Q000378:metabolism / Q000473:pathology; D000075163:Metallocenes; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D005296:Ferrous Compounds; D007504:Iron Radioisotopes; D000075163:Metallocenes; D009942:Organometallic Compounds; D054354:Iron Carbonyl Compounds; C050224:3,5,5-trimethylhexanoylferrocene; D007501:Iron