An evaluation of three neuroleptanalgesic combinations in rabbits.
In this study, novel combinations of analgesics and neuroleptics were used in the rabbit in an attempt to produce a surgical level of anesthesia. A commercially available mixture of fentanyl (0.06 mg/kg) and droperidol (3.0 mg/kg; F/D) was evaluated alone and in combination with either the benzodiazepine derivative, diazepam (2 mg/kg) or the alpha-2 adrenoceptor agonist, detomidine (20 micrograms/kg). Rabbits were anesthetized on consecutive weeks with one of the three regimens. Heart rate, respiratory rate, blood pressure, and arterial blood gases (pH, PCO2, PO2) were measured throughout each trial. The times of loss and return of palpebral, righting, and pedal reflexes were recorded. The addition of diazepam to the F/D combination caused marked prolongation of the duration of reflex loss for all reflexes. If the duration of reflex loss for F/D is considered to be 100%, then F/D plus diazepam (F/D/diazepam) prolonged the duration of reflex loss to 547% and 204% for righting and pedal reflex, respectively. The combination of F/D/diazepam produced significantly different results from those for either of the other combinations for righting reflex and palpebral reflex. The results for F/D/diazepam were also markedly different from F/D for pedal reflex, but were not significantly different from those for F/D/detomidine. Prolongation of the duration of reflex loss was more moderate with the addition of detomidine (148% and 174% for righting and pedal reflexes, respectively). Reflexes persisted in some rabbits for each anesthetic regimen. Palpebral reflex was preserved in one of the rabbits given F/D/diazepam, four of five rabbits given F/D, and in two rabbits given F/D/detomidine.(ABSTRACT TRUNCATED AT 250 WORDS)
Marini
R P
RP
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139-4307.
Hurley
R J
RJ
Avison
D L
DL
Lipman
N S
NS
D000700:Analgesics / Q000008:administration & dosage* / Q000633:toxicity; D000758:Anesthesia / Q000379:methods / Q000662:veterinary*; D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000008:administration & dosage / Q000633:toxicity; D004329:Droperidol / Q000008:administration & dosage / Q000633:toxicity; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000633:toxicity; D006339:Heart Rate / Q000187:drug effects; D007093:Imidazoles / Q000008:administration & dosage / Q000633:toxicity; D011817:Rabbits / Q000502:physiology / Q000601:surgery; D012018:Reflex / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D000700:Analgesics; D014150:Antipsychotic Agents; D004338:Drug Combinations; D007093:Imidazoles; C041255:detomidine; D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl