[The blood pro- and antioxidant status in patients with chronic glomerulonephritis and disordered kidney function undergoing treatment with peroral sorbents].
It was found that there is unbalance between accumulation of lipid peroxidation (LPO) products and antioxidant potential in blood plasma and red cells from chronic glomerulonephritis patients with renal dysfunction. The unbalance cannot be corrected by standard conservative therapy. Oral sorbents result in normalization of the plasma abnormalities, but a long-term intake of coal depletes antioxidant defense which is likely to occur because of low plasma tocopherol levels. Vitamin E deficiency aggravates LPO adverse effects. It is recommended to combine long-term course of enterosorbents with parenteral antioxidant drugs.
Tugusheva
F A
FA
Kulikova
A I
AI
Lukichev
B G
BG
Zubina
I M
IM
D000284:Administration, Oral; D000975:Antioxidants / Q000032:analysis*; D002908:Chronic Disease; D016061:Enterosorption / Q000379:methods*; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism; D005921:Glomerulonephritis / Q000097:blood* / Q000150:complications / Q000628:therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology / Q000628:therapy; D015227:Lipid Peroxidation; D017382:Reactive Oxygen Species / Q000032:analysis*
D000975:Antioxidants; D017382:Reactive Oxygen Species
Sostoianie pro- i antioksidantnogo statusa krovi bol'nykh khronicheskim glomerulonefritom s narusheniem funktsii pochek pri lechenii peroral'nymi sorbentami.