title: Histologic changes after stenting of the pancreatic duct.
abstract: The placement of stents has been proposed as a possible modality to treat pancreatic diseases. Ductal changes observed on endoscopic retrograde cholangiopancreatography during stenting are believed to be reversible when the stents are removed. We describe a patient with normal anatomy on baseline pancreatograms who underwent endoscopic sphincterotomy, followed by stent placement for 9 months. Symptoms progressed, leading to a pancreaticoduodenectomy. Histologic evaluation of the head of the pancreas revealed more extensive inflammatory changes in the duct and parenchyma drained by the stent. This suggests that stent-induced changes noted on pancreatography correspond to parenchymal changes that may be severe and irreversible.
authors.affiliation: Department of Surgery, University of California-Los Angeles School of Medicine.
authors.forename: C
authors.initials: C
authors.lastname: Alvarez
authors.forename: M
authors.initials: M
authors.lastname: Robert
authors.forename: S
authors.initials: S
authors.lastname: Sherman
authors.forename: H A
authors.initials: HA
authors.lastname: Reber
mesh_terms: D002760:Cholangiopancreatography, Endoscopic Retrograde; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000473:pathology*; D016577:Pancreaticoduodenectomy; D010195:Pancreatitis / Q000175:diagnosis* / Q000601:surgery*; D012008:Recurrence; D016717:Sphincterotomy, Endoscopic; D015607:Stents