[Radioprotective effect of alpha 2- adrenoreceptor agonists].
It is confirmed in experiments with selective antagonists, that radioprotective effects (RPE) of phenylephrine is realised by means of alpha 1--and RPE of clonidine--by means of alpha 2-adrenoceptors (AR). Guanobenz, more selective alpha 2-agonist with another structure, has high RPE too. Chemical analogues of clonidine (alpha-antagonist phentolamine, L-DOPA, DOP-serine), which don't cause selective stimulation of alpha 2-AR, don't protect mice. alpha 2-Agonists are new effective group of radioprotectors.
Kulinskiĭ
V I
VI
Kovtun
V Iu
VIu
Klimova
A D
AD
Iashunskiĭ
V G
VG
D000316:Adrenergic alpha-Agonists / Q000378:metabolism*; D000818:Animals; D003000:Clonidine / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010656:Phenylephrine / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000378:metabolism*; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*
D000316:Adrenergic alpha-Agonists; D011837:Radiation-Protective Agents; D018341:Receptors, Adrenergic, alpha-2; D010656:Phenylephrine; D003000:Clonidine
Radiozashchitnyĭ éffect agonistov alfa 2- adrenotseptorov.