title: Sulfasalazine induced seizures and dysphasia.
abstract: We describe the case of a 46-year-old woman with rheumatoid arthritis who developed a severe reaction to sulfasalazine, characterized by dysphasia, seizures, rash and the development of strongly positive pANCA (perinuclear antineutrophil cytoplasmic antibodies). Her condition improved spontaneously upon withdrawal of sulfasalazine. Dysphasia has not been reported as a side effect of sulfasalazine.
authors.affiliation: Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: M E
authors.initials: ME
authors.lastname: Hill
authors.forename: C
authors.initials: C
authors.lastname: Gordon
authors.forename: R D
authors.initials: RD
authors.lastname: Situnayake
authors.forename: D A
authors.initials: DA
authors.lastname: Heath
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001037:Aphasia / Q000139:chemically induced*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced*; D012460:Sulfasalazine / Q000009:adverse effects*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D012460:Sulfasalazine