title: Ki-1-positive large-cell cutaneous lymphoma mimicking a Stewart-Treves angiosarcoma.
abstract: Anaplastic large-cell cutaneous lymphomas (ALCL) represent a heterogeneous group. Primitive cutaneous lymphomas are exceptional, sometimes with a deceptive clinical aspect, but must be considered as a distinct clinicopathologic entity. We report a case of a cutaneous ALCL, appearing 7 years after a homolateral Hodgkin ganglionic lymphoma and occurring on a chronic lymphoedema of the arm. A Stewart-Treves angiosarcoma was suggested owing to its location, vascular aspect and low histologic differentiation. Immunohistochemistry was helpful in making the diagnosis of ALCL. Southern blotting analysis revealed a rearrangement of the beta-chain of the T-receptor gene, thus suggesting the T-cell origin of this lymphoma.
authors.affiliation: Service de Dermatologie, Hôpital du Haut-Lévêque, CHU de Bordeaux, Pessac, France.
authors.forename: M
authors.initials: M
authors.lastname: Beylot-Barry
authors.forename: B
authors.initials: B
authors.lastname: Vergier
authors.forename: C
authors.initials: C
authors.lastname: Beylot
authors.forename: A
authors.initials: A
authors.lastname: Demascarel
authors.forename: M S
authors.initials: MS
authors.lastname: Doutre
mesh_terms: D000368:Aged; D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D014953:Wrist
chemical_list: D004273:DNA, Neoplasm