The antiepileptic effect of low-dose amino-phosphono-valeric acid (APV) is not enhanced by phosphatidylserine association.
We investigated the effects of the NMDA antagonist amino-phosphono-valeric acid (APV), alone or in combination with phosphatidylserine (PS) in the penicillin model of epilepsy. After penicillin injection, rats were treated i.p. with either APV alone (5 mg/Kg) or APV (5 mg/Kg) + PS (740 mg/Kg). EEG epileptic activity decreased significantly in the group treated with APV alone, even at the very low dose used. This effect was not further enhanced by PS, suggesting that the previously reported effects of PS on GABA activity may be related to a specific interaction between these compounds.
Loeb
C
C
Department of Neurology, University of Genoa, Italy.
Patrone
A
A
Besio
G
G
Balestrino
M
M
Mainardi
P
P
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D010400:Penicillin G; D010718:Phosphatidylserines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010718:Phosphatidylserines; D015763:2-Amino-5-phosphonovalerate; D010400:Penicillin G