The humoral immune response to Chlamydia trachomatis in patients with acute reactive arthritis.
Sera from 25 patients with clinical signs of reactive arthritis were analysed for antibodies against Chlamydia trachomatis by immunoblotting. Purified elementary bodies, purified Chlamydia outer membrane complexes, and purified recombinant subcomponents were used as antigens. Antibodies against C. trachomatis cysteine rich outer membrane protein 2 (Omp2) and lipopolysaccharide (LPS) were detected in 10 patients. Thus 40% of the patients presented antibodies specific for C. trachomatis. There was no correlation between acute reactive arthritis and antibodies to heat-shock proteins GroEL, GroES and DnaK.
Larsen
B
B
Institute of Medical Microbiology, University of Aarhus, Denmark.
Birkelund
S
S
Mordhorst
C H
CH
Ejstrup
L
L
Andersen
L S
LS
Christiansen
G
G
D000208:Acute Disease; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D016918:Arthritis, Reactive / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D001426:Bacterial Proteins / Q000276:immunology; D001483:Base Sequence; D018834:Chaperonin 60; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D018834:Chaperonin 60; D006360:Heat-Shock Proteins