Incorporation of lactate measurement in multi-spin-echo proton spectroscopic imaging.
An improved multi-slice, multi-spin-echo proton spectroscopic imaging method for human brain is presented. The technique allows the reconstruction of lactate images, along with choline plus creatine, N-acetylaspartate, and lipid images from one single data set processed in three separate ways. The discrimination between resonances of lipid protons and lactate methyl protons is based on homonuclear spin-spin coupling. The reliability of the separation of the lipid and lactate contribution depends on the T2 of the lipid resonances. Measurements were performed on a standard 1.5 Tesla clinical scanner on healthy volunteers and a patient with high grade CNS lymphoma, demonstrating the ability to obtain high quality metabolite maps within 11 min.
Duyn
J H
JH
Laboratory of Diagnostic Radiology Research, Office of Intramural Research, National Institutes of Health, Bethesda, MD 20892.
Frank
J A
JA
Moonen
C T
CT
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000378:metabolism*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007773:Lactates / Q000032:analysis*; D019344:Lactic Acid; D008055:Lipids / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008961:Models, Structural; D013997:Time Factors
D007773:Lactates; D008055:Lipids; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline