Platelet serotonin and plasma tryptophan in depressed patients: effect of drug treatment and clinical outcome.
Platelet serotonin and plasma tryptophan were studied in healthy subjects and in depressed patients before and during their antidepressant drug treatment. Before treatment, mean platelet serotonin level was normal in depressed patients compared with healthy subjects while a significant decrease in patients' plasma TRP was noted (t = 6.0, p < .001). The concentrations of platelet 5-HT level did not correlate with either plasma TRP or with clinical variables, that is, AMDP depression and AMDP anxiety scores. Antidepressant drugs treatment decreased platelet 5-HT level (ANOVA F = 8.27, p < .001) whatever the clinical outcome of the patient, whereas the changes observed in plasma TRP were positively related to the mood state change. These results suggest that platelet serotonin could be a good pharmacological model but has no relevance concerning the mood state.
Karege
F
F
Institutions Universitaires de Psychiatrie de Genève, Switzerland.
Widmer
J
J
Bovier
P
P
Gaillard
J M
JM
D000339:Affect / Q000187:drug effects; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000097:blood*; D016896:Treatment Outcome; D014364:Tryptophan / Q000097:blood*
D000928:Antidepressive Agents; D012701:Serotonin; D014364:Tryptophan