Neuromuscular blocking effect of thiamphenicol on frog rectus abdominis muscle.
1. In the present study, thiamphenicol caused a significant fall in ACh-induced frog rectus abdominis muscle contraction peaks and significant rightward shifts of the contractile response curves in a dose-dependent manner. 2. In addition, the maximal ACh response of muscle could not be obtained in presence of thiamphenicol. On the other hand, thiamphenicol did not alter KCl-induced contractions of the muscle at the same concentrations. 3. In contrast chloramphenicol did not cause any significant change in ACh-induced contraction peaks. 4. These results have suggested that thiamphenicol may have a neuromuscular blocking effect on frog rectus abdominis muscle.
Erenmemisoglu
A
A
Department of Pharmacology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Tekol
Y
Y
Gogusten
B
B
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001001:Anura; D066298:In Vitro Techniques; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D013839:Thiamphenicol / Q000494:pharmacology*
D009466:Neuromuscular Blocking Agents; D011189:Potassium Chloride; D013839:Thiamphenicol; D000109:Acetylcholine