Proliferating normal bone marrow cells do stain for Ki-67 antigen.
The normal human bone marrow has been investigated in the past for the presence of the proliferation associated antigen detected by the Ki-67 antibody and aberrantly low scores for this antigen have been reported. We used a new Ki-67 equivalent antibody (MIB 1) and a formalin fixation of smears and trephine biopsies, and we report 52.8% +/- 9.2 SD of the normal BM cells to stain for MIB 1. Late forms of the maturing blood cells compartment such as metamyelocytes and megakaryocytes were stained in cytokine-treated marrows.
Cattoretti
G
G
Department of Pathology, Istituto Nazionale Tumori, Milano, Italy.
Orazi
A
A
Gerdes
J
J
D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D002455:Cell Division; D015672:Erythroid Precursor Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D019394:Ki-67 Antigen; D008533:Megakaryocytes / Q000166:cytology; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*
D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins