The modification and assembly of proteins in the endoplasmic reticulum.
Proteins fold and assemble in the endoplasmic reticulum in an environment that is very different from the cytosol. The presence of relatively high concentrations of calcium, an oxidizing state, ATP and lumenal proteins are all important in mediating these events.
Gaut
J R
JR
Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Hendershot
L M
LM
D000818:Animals; D018833:Chaperonins; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004721:Endoplasmic Reticulum / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry
D008565:Membrane Proteins; D010455:Peptides; D011506:Proteins; D018833:Chaperonins