title: Market penetration of new drugs in one United Kingdom region: implications for general practitioners and administrators.
abstract: OBJECTIVE
  To determine the use of new drugs in one United Kingdom region.
  
  
  METHODS
  Examination of data on prescribing of angiotensin converting enzyme inhibitors, new broad spectrum antibiotics, and H2 receptor antagonists. Calculation of number of defined daily doses prescribed each month.
  
  
  METHODS
  All general practices in Northern Ireland.
  
  
  METHODS
  Drug use index and market share of each drug.
  
  
  RESULTS
  During 1988-91 prescribing of angiotensin converting enzyme inhibitors increased by 126%, of H2 receptor antagonists by 46%, and of new antibiotics by 207%. The first drug on the market usually retained the largest market share. Use of oral antibiotics increased threefold irrespective of the reporting policy of the general practitioners' local laboratory.
  
  
  CONCLUSIONS
  The increase in prescribing of these drugs seems to be greater than can be accounted for by an increase in patients with specific indications for these drugs. This suggests that the profession has not instituted effective checks to ensure that the legitimate promotion of new products does not lead to inappropriate and wasteful use.
authors.affiliation: Department of Therapeutics and Pharmacology, Queen's University of Belfast.
authors.forename: H
authors.initials: H
authors.lastname: McGavock
authors.forename: C H
authors.initials: CH
authors.lastname: Webb
authors.forename: G D
authors.initials: GD
authors.lastname: Johnston
authors.forename: E
authors.initials: E
authors.lastname: Milligan
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004345:Drug Industry; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D017723:Drug Utilization Review / Q000706:statistics & numerical data*; D005194:Family Practice / Q000592:standards / Q000706:statistics & numerical data*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D009660:Northern Ireland; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000900:Anti-Bacterial Agents; D006635:Histamine H2 Antagonists