Cardiac transplantation at UCLA.
In the last decade, the number of patients undergoing heart transplantation has steadily increased as a result of expanding indications for cardiac transplantation. The limitation on the number of transplants performed has been the scarcity of donor organs. At UCLA, 320 heart transplant procedures were performed in adults through the end of 1992; 173 patients (54%) underwent transplantation for ischemic cardiomyopathy; 104 (33%) for dilated cardiomyopathy, and 13 (4%) for severe rejection or cardiac allograft vasculopathy. The mean number of rejection episodes and infections per patient per year in the first posttransplant year was 1.28 and 0.58, respectively. Early mortality (30 days) was 5.7%, while 1-, 3-, and 5-year survival rates were 84.3%, 74.3%, and 67.5%, respectively. Survival of patients transplanted for ischemic cardiomyopathy and idiopathic cardiomyopathy was nearly equal. Survival was also comparable in patients aged 60 years and over (n = 71) and those under age 60. We observed improved patient outcome including shorter posttransplant hospital stay, time to extubation, and lower incidences of infections, rejection episodes, and renal failure in patients transplanted in 1991 and 1992. This observation was interesting in view of the increased proportion of critically ill patients in this group (46% UNOS Status 1) compared with patients transplanted in the previous years (30% UNOS Status 1).(ABSTRACT TRUNCATED AT 250 WORDS)
Ardehali
A
A
Department of Surgery, UCLA School of Medicine.
Laks
H
H
Drinkwater
D C
DC
Ziv
E T
ET
Sorensen
T J
TJ
Hamilton
M A
MA
Warner-Stevenson
L
L
Moriguchi
J B
JB
Kobashigawa
J A
JA
D000046:Academic Medical Centers; D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D002423:Cause of Death; D005260:Female; D006084:Graft Rejection / Q000401:mortality / Q000517:prevention & control; D006085:Graft Survival; D016027:Heart Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D006801:Humans; D007165:Immunosuppression Therapy; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D009927:Tissue and Organ Procurement