Effects of naftidrofuryl oxalate, a 5-HT2 antagonist, on neuronal damage and local cerebral blood flow following transient cerebral ischemia in gerbils.
Effects of naftidrofuryl oxalate (naftidrofuryl), a 5-HT2 antagonist, on neuronal damage and local cerebral blood flow was examined in a gerbil model of transient forebrain ischemia. Effect of ketanserin tartrate (ketanserin), another 5-HT2 antagonist, on neuronal damage was also examined. Pretreatment with naftidrofuryl or ketanserin prevented hippocampal CA1 neuronal loss after 5 min of transient ischemia. Naftidrofuryl did not improve hippocampal blood flow during and 1 h after transient ischemia determined by [14C]iodoantipyrine autoradiography but increased blood flow in the caudate-putamen 1 h after transient ischemia. The results show that: (1) the 5-HT2 antagonists protect against hippocampal CA1 neuronal damage; and (2) the protective effect of naftidrofuryl may not be caused by a hemodynamic mechanism but by a direct inhibitory neuromodulation via 5-HT2 antagonistic action.
Fujikura
H
H
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Kato
H
H
Araki
T
T
Ban
H
H
Hasegawa
Y
Y
Kogure
K
K
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005849:Gerbillinae; D006624:Hippocampus / Q000098:blood supply / Q000473:pathology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D002546:Ischemic Attack, Transient / Q000473:pathology*; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D009257:Nafronyl / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects
D006635:Histamine H2 Antagonists; D009257:Nafronyl; D007650:Ketanserin