title: Clonazepam withdrawal in 13 patients with active epilepsy and drug side effects.
abstract: We report the end result of clonazepam (CZP) withdrawal in 13 patients with significant side effects felt to be due to CZP. The present observations supplement the recent report in Seizure by Chataway et al., in proposing a safe CZP withdrawal rate of 0.2 mg/day. Eight of the patients had withdrawal seizures, five had withdrawal symptoms and four patients had no withdrawal problems at all. Ultimately all the patients came off CZP, mainly quite rapidly (3-30 days) with the initial side effects regressing totally in 11 patients.
authors.affiliation: Epilepsy Unit, Westmead Hospital, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Buchanan
authors.forename: C
authors.initials: C
authors.lastname: Sharpe
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002998:Clonazepam / Q000009:adverse effects*; D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome; D016896:Treatment Outcome
chemical_list: D002998:Clonazepam