Inherited cancers associated with the RET proto-oncogene.
Mutations in the RET proto-oncogene have been identified in the constitutional DNA of patients with the inherited disorders multiple endocrine neoplasia type 2A and 2B and familial medullary thyroid carcinoma. This review focuses on the discoveries over the past year that pointed to RET as a candidate gene, and on the nature and spectrum of what appear to be dominant mutations associated with an inherited predisposition to tumor development.
Goodfellow
P J
PJ
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110.
D000595:Amino Acid Sequence; D001483:Base Sequence; D018276:Carcinoma, Medullary / Q000235:genetics; D002874:Chromosome Mapping; D004273:DNA, Neoplasm / Q000235:genetics; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D018813:Multiple Endocrine Neoplasia Type 2a / Q000235:genetics; D018814:Multiple Endocrine Neoplasia Type 2b / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D010641:Phenotype; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D013964:Thyroid Neoplasms / Q000235:genetics
D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas