Characterization of a yeast artificial chromosome from human chromosome band 13q12 containing the FLT1 and FLT3 receptor-type tyrosine kinase genes.
A yeast artificial chromosome containing the two receptor-type tyrosine kinase genes FLT1 and FLT3 was isolated, analyzed, and compared to a genomic map in order to establish their organization and linkage. FLT1 and FLT3 are physically linked in a head-to-tail configuration and separated by about 150 kb. The region contains three CpG islands. Two of them are likely to correspond to FLT1 and FLT3, whereas the third one is suggestive of another putative, unidentified RTK gene.
Imbert
A
A
Laboratoire d'Oncologie Moléculaire, U.119 INSERM, Marseille, France.
Rosnet
O
O
Marchetto
S
S
Ollendorff
V
V
Birnbaum
D
D
Pébusque
M J
MJ
D001483:Base Sequence; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002882:Chromosomes, Human, Pair 13; D015342:DNA Probes; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics
D015342:DNA Probes; D020794:Receptor Protein-Tyrosine Kinases