Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas.
Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (X2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.
Suzui
H
H
Department of Neurosurgery, Faculty of Medicine, Kyoto University, Japan.
Takahashi
J A
JA
Fukumoto
M
M
Hashimoto
N
N
Itoh
N
N
Hatanaka
M
M
Kikuchi
H
H
D000236:Adenoma / Q000276:immunology / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism; D001483:Base Sequence; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000276:immunology / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000276:immunology / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D018809:Proliferating Cell Nuclear Antigen; D012333:RNA, Messenger / Q000096:biosynthesis; D017468:Receptors, Fibroblast Growth Factor / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism*; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism
D000951:Antigens, Neoplasm; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; D009418:S100 Proteins; D016222:Fibroblast Growth Factor 2