Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19.
Human alpha-(1.3/1,4) fucosyltransferase (FucT-III) gene and alpha 1,3 fucosyltransferase (FucT-VI) gene were found in the 38-kb fragment isolated from a human cosmid library. These genes were present 13 kb apart in tandem orientation. The FucT-III gene has already been mapped on the Lewis locus of chromosome 19. This demonstrated that FucT-VI gene was localized close to the Lewis locus on chromosome 19.
Nishihara
S
S
Division of Cell Biology, Soka University, Tokyo, Japan.
Nakazato
M
M
Kudo
T
T
Kimura
H
H
Ando
T
T
Narimatsu
H
H
D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003360:Cosmids; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005647:Fucosyltransferases / Q000235:genetics*; D015698:Genomic Library; D006801:Humans; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D015345:Oligonucleotide Probes; D004247:DNA; D005647:Fucosyltransferases; C031692:galactoside 3-fucosyltransferase; C019818:3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase