title: Does HIV disrupt a naturally occurring immune modulation system?
abstract: An immune modulation complex is proposed which recognizes and is driven by an MHC presented epitope of the CD4 molecule present on the surface of up regulated CD4+ lymphocytes. Immune modulation is affected by both CD4 lymphocyte destruction and impairment of their potential for immune recognition. These two processes are carefully controlled by an idiotypic, anti-idiotypic feedback mechanism. The CD4 tropic area of HIV impersonates some components of that feedback loop resulting in increased CD4 lymphocyte destruction.
authors.forename: J R
authors.initials: JR
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D015704:CD4 Antigens; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003384:Coxsackievirus Infections / Q000276:immunology; D005246:Feedback; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000502:physiology*; D008954:Models, Biological; D009205:Myocarditis / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D015704:CD4 Antigens