title: [Absence of correlation between HLA antigens and fibromyalgia syndrome in Italian patients].
abstract: Fibromyalgia syndrome (FS) is a frequently seen extra-articular rheumatism of unknown etiology. Some authors have suggested a direct role of the immune system in the pathogenesis of the disease while others have found an increased prevalence of some HLA DR and B antigens. The aim of our study was to verify the possible association between HLA and FS in Italian patients with no clinical or immunological evidence of chronic rheumatic inflammatory diseases. Ninety-two consecutive Italian patients were evaluated: 86 were typed for HLA A-B-C antigens and 74 for HLA DR antigens. The study was performed by standard NIH microlymphocytotoxicity technique and by NIH prolonged technique on B lymphocyte purified preparations. There was no statistically significant difference between any HLA A-B-C and DR antigens in the patients compared with the controls. We conclude that in the pathogenesis of FS there is no clear cut evidence of immunologic or genetic involvement.
authors.affiliation: Istituto di Reumatologia, Università degli Studi di Siena.
authors.forename: G
authors.initials: G
authors.lastname: Biasi
authors.forename: A
authors.initials: A
authors.lastname: Fioravanti
authors.forename: M
authors.initials: M
authors.lastname: Galeazzi
authors.forename: R
authors.initials: R
authors.lastname: Marcolongo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005356:Fibromyalgia / Q000097:blood / Q000276:immunology*; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D007558:Italy; D008297:Male; D013577:Syndrome
chemical_list: D006680:HLA Antigens
vernacular_title: Assenza di correlazione fra antigeni HLA e sindrome fibromialgica in pazienti italiani.