title: Vitamin C in CC14 hepatotoxicity--a preliminary report.
abstract: 1. The hepatotoxic effect of CC14 was studied in the rat by using 3 well established liver function tests (plasma glucose, bilirubin and proteins) as indices of hepatic integrity. 2. The protective effect of vitamin C against this hepatotoxicity was also investigated. 3. CC14 (8 ml kg-1 body weight) caused a decrease in the levels of plasma conjugated bilirubin, glucose and protein. 4. Vitamin C (2 g kg-1 body weight) prevented liver damage induced by CC14. The possible mechanisms of protection are highlighted.
authors.affiliation: Department of Biochemistry, College of Health Sciences, Ogun State University, Ago-Iwoye, Nigeria.
authors.forename: O
authors.initials: O
authors.lastname: Ademuyiwa
authors.forename: O
authors.initials: O
authors.lastname: Adesanya
authors.forename: O R
authors.initials: OR
authors.lastname: Ajuwon
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D002251:Carbon Tetrachloride; D001205:Ascorbic Acid; D001663:Bilirubin