[Study by EPR of structural modifications on liposomes induced by two metabolites of modafinil].
Awaking properties of modafinil are well known at this time, but its action mode is still hypothetic. Our contribution is limited to the study of the membrane structural modifications carried by this drug and two metabolites. By EPR spectroscopy, we have studied the two metabolites which are distinguished by acid function for the first one and sulfone function for the second one. These two metabolites have no waking properties when they are administrated to animals but one of these two metabolites has the same behaviour than modafinil on membrane action.
Abel-Coindoz
C
C
Département de Biophysique, Centre de Recherches du Service de Santé des Armées, La Tronche.
Vezin
H
H
Daveloose
D
D
Roussel
B
B
Viret
J
J
D001559:Benzhydryl Compounds / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D066298:In Vitro Techniques; D008081:Liposomes; D000077408:Modafinil
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D008081:Liposomes; D000077408:Modafinil
Etude par RPE des modifications structurales induites sur les liposomes par deux métabolites du modafinil.