title: [Suicide with prothipendyl].
abstract: The distribution of prothipendyl (Dominal) in two cases of fatal poisoning are reported. The highest concentration of prothipendyl were found in liver (1.2 g/kg to 1.8 g/kg) and kidney (0.6 g/kg). Prothipendyl concentrations in these organs far exceeded those in blood. In the first case we found a blood concentration 200 times over the therapeutic range. Prothipendyl was detected in all specimens tested including: lung, muscle and stomach. These results are in agreement with limited, previously reported data and indicate that more then 4 g of prothipendyl is fatal overdose. In this report the survival time and dose are discussed.
authors.affiliation: Institut für Rechtsmedizin, Universität Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Wu
authors.forename: G
authors.initials: G
authors.lastname: Schmitt
authors.forename: R
authors.initials: R
authors.lastname: Mattern
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D062787:Drug Overdose / Q000097:blood* / Q000175:diagnosis; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy; D013405:Suicide / Q000331:legislation & jurisprudence*; D013843:Thiazines / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D014018:Tissue Distribution
chemical_list: D014150:Antipsychotic Agents; D013843:Thiazines; C069248:prothipendyl
vernacular_title: Suizid mit Prothipendyl.