[Experimental evaluation of anti-seborrheic substances].
The effects of different drugs on the sebaceous gland is described by the use of an animal model. A castrated rat Wistar was made hyperseborrheic with implant of testosterone. On this model, graduated by a different anti androgen (acetate of cyproterone), anti-seborrheic effect is measured, bound or not the antiandrogenic effect of retinoids, cimetidine, spironolactone and, minoxidil. Retinoids reduced the surface of sebaceous glands but did not express an anti-androgenic effect. Cimetidine and spironolactone presented the same action. Minoxidil had no effect on this model.
Bazex
J
J
Service Dermatologie, Hôpital Purpan, Toulouse.
Garigue
J
J
D000818:Animals; D012628:Dermatitis, Seborrheic / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D051381:Rats; D017208:Rats, Wistar
Evaluation expérimentale de substances anti-séborrhéiques.