Cardiopathy and ocular abnormalities in Noonan syndrome.
We describe three children with Noonan syndrome with cardiopathy. One female child had cardiopathy and ocular abnormalities. The other two male children had congenital heart disease of which one had uncommon association of tricuspid valve dysplasia with regurgitation associated with endocardial cushion defect. Karyotypes of the female and one of the male children were normal. The growth hormone and thyroid hormone studies in the first and second male children were normal. All the three children were managed conservatively and followed-up.
Ram
S P
SP
Department of Paediatrics, Hospital Universiti Sains Malaysia, Kelantan.
Krishna
T N
TN
D006332:Cardiomegaly / Q000473:pathology; D002648:Child; D005124:Eye Abnormalities / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000473:pathology*; D006801:Humans; D008297:Male; D009634:Noonan Syndrome / Q000473:pathology*; D010375:Pedigree; D011666:Pulmonary Valve Stenosis / Q000473:pathology; D014262:Tricuspid Valve Insufficiency / Q000473:pathology