New perspectives on the clinical neurobiology of treatment response in schizophrenia.
A structured approach is used to review the rapid progress in neurobiology related to treatment response in schizophrenia. Findings are presented and discussed according to the molecular, cellular and regional levels of brain organization. The genotype-phenotype structure is used to consider potential interactions between genes, clinical manifestations of the illness and treatment response. The integration of neurobiological research into the future development of new treatment strategies for schizophrenia holds significant promise.
Honer
W G
WG
Department of Psychiatry, University of British Columbia, Vancouver.
D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D005838:Genotype; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D009435:Synaptic Transmission / Q000187:drug effects / Q000235:genetics / Q000502:physiology
D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter