Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets.
The C4-photocycloadduct psoralen-linolenic acid activates protein kinase C (PKC), in human platelets, which in turn phosphorylates 47 kDa protein, representing its major substrate in these cells. This behaviour is similar to that shown by diacylglycerol, a main second messenger responsible of various biological effects, e.g. of melanogenesis.
Caffieri
S
S
Department of Pharmaceutical Sciences of the University, Padua, Italy.
Ruzzene
M
M
Guerra
B
B
Frank
S
S
Vedaldi
D
D
Dall'Acqua
F
F
D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D001798:Blood Proteins / Q000302:isolation & purification / Q000378:metabolism; D004789:Enzyme Activation; D011564:Furocoumarins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010750:Phosphoproteins / Q000097:blood / Q000302:isolation & purification; D010766:Phosphorylation; D011494:Protein Kinases / Q000097:blood* / Q000187:drug effects; D014466:Ultraviolet Rays; D017962:alpha-Linolenic Acid / Q000494:pharmacology*
D001798:Blood Proteins; D011564:Furocoumarins; D010750:Phosphoproteins; D017962:alpha-Linolenic Acid; D011494:Protein Kinases; D001241:Aspirin