T cell subsets involved in immunity against polyoma virus-induced tumors.
Lymphocyte subsets involved in the rejection of polyoma virus-induced tumors were studied. Depletion of CD4+ and CD8+ T cells as well as natural killer cells was performed in mice using monoclonal antibodies or anti-asialo GM1 anti-serum. Both CD4+ and CD8+ T cell subsets were found to be necessary for the rejection of polyoma virus-induced tumors, while natural killer cells played a minor, if any, role.
Liunggren
G
G
Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden.
Liunggren
H G
HG
Dalianis
T
T
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D002455:Cell Division; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D030361:Papillomavirus Infections / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*
D016827:CD8 Antigens