Loss of circadian rhythm in luminal acidity of canine stomach by implantation of a gastric fistula.
One to four months after implantation of a gastric fistula, a circadian rhythm in gastric acidity could be demonstrated by use of the intragastric 24-hour pH-metry in dogs with the gastric fistula protruding on the left side of the upper abdomen. This circadian rhythm was found to be fully developed within 3 years, and it remained unchanged up to 5 years after implantation. It is characterized by a daytime intragastric median pH of about 2 and a nocturnal intragastric median pH of about 7. In contrast, a circadian rhythm did not develop within 5 months after instrumentation of the dogs with a gastric fistula protruding on the right side of the upper abdomen. Only 2 years after implantation of the fistula, an intragastric daytime median pH of about 2 and a nocturnal median pH of about 4 appeared. Four years after implantation, the circadian rhythm had evolved. The results show a delayed postoperative restoration of circadian rhythm in canine gastric acidity if a gastropexy occurs at an untolerated position. This may lead to unphysiological distensions in the gastric wall with subsequent continuous stimulation of acid secretion.
Postius
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S
Department of Pharmacology, Byk Gulden Pharmaceuticals, Konstanz, FRG.
Bräuer
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U
D000009:Abdominal Muscles / Q000601:surgery; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005747:Gastric Fistula / Q000503:physiopathology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D019736:Prostheses and Implants; D013270:Stomach / Q000601:surgery; D013997:Time Factors