Genetic variation at the ApoB 3'HVR, D2S44, and D7S21 loci in the Ewondo Ethnic Group of Cameroon.
A sample of the Ewondo population (a Bantu-speaking group of Southern Cameroon) was analyzed for the polymorphism at three tandem repeated DNA loci (ApoB 3' HVR, D2S44, and D7S21). We observed a greater number of ApoB 3' HVR alleles (17) and a significantly higher estimated heterozygosity (.879 +/- .011) than in previously surveyed populations, with the exception of U.S. Blacks. The higher genetic variability of Ewondo and U.S. Blacks was also shown by the ApoB 3' HVR allele-frequency spectra. A method for measuring population distances, based on cumulative fragment-size distribution, is described. Interpopulation comparisons for ApoB 3' HVR were carried out by this method and were compared with those obtained by a genetic distance measurement. The two sets of results showed a consistent pattern of population differentiation: the Ewondos and the U.S. Blacks clustered together and were well apart from both a Caucasian cluster (Swedes, U.S. Whites, Italians, and Germans) and other well-defined populations (Sikhs of India and Pehuence Indians of Chile). Profile distances were then computed from D2S44 and D7S21 bined data. This analysis indicated a genetic affinity between Ewondos, U.S. Blacks, and Afro-Caribbean Blacks and outlined the genetic diversity between Ewondos, Caucasians, and Asian Indians.
Destro-Bisol
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Laboratorio di Immunoematologia, Università Cattolica del S. Cuore, Rome, Italy.
Presciuttini
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S
d'Aloja
E
E
Dobosz
M
M
Spedini
G
G
Pascali
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VL
D017954:Africa South of the Sahara / Q000208:ethnology; D000483:Alleles; D001055:Apolipoproteins B / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D002163:Cameroon; D017691:Caribbean Region; D002889:Chromosomes, Human, Pair 2; D002897:Chromosomes, Human, Pair 7; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D007194:India; D007199:Indians, South American / Q000235:genetics; D008957:Models, Genetic; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D014481:United States; D044465:White People / Q000235:genetics; D001741:Black or African American
D001055:Apolipoproteins B