title: Effect of intramuscular administration of thiazinamium and inhaled histamine on forced inspiratory volume in 1 s.
abstract: Twenty-one patients with symptoms suggestive of asthma were evaluated clinically by allergy skin tests, pulmonary function, and histamine inhalation challenge. In addition to the forced expiratory manoeuvres (FEV1), forced inspiratory manoeuvres (FIV1), were performed before and after intramuscular administration of thiazinamium (Multergan), a bronchodilator with markedly anticholinergic properties. The same lung function parameters (FEV1 and FIV1) were obtained before and after histamine inhalation challenge. The response after bronchodilatation in litres of FEV1 2.42 +/- 1.12 to 3.27 +/- 0.98 (mean +/- SD) was much larger than in FIV1 3.44 +/- 1.35 to 4.05 +/- 1.14 (p < 0.05). After histamine inhalation the observed decrease in FEV1 (2.65 +/- 0.99 to 2.06 +/- 0.89) was not so great as in FIV1 (3.76 +/- 1.09 to 2.90 +/- 1.15) (p < 0.02). These results suggest that patients often have more difficulty with inspiration rather than expiration.
authors.affiliation: Asthma Clinic, Beatrixoord Hospital, Haren, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Gimeno
authors.forename: R
authors.initials: R
authors.lastname: van Altena
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007273:Injections, Intramuscular; D007320:Inspiratory Capacity / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011398:Promethazine / Q000008:administration & dosage / Q000494:pharmacology*; D015656:Respiratory Mechanics / Q000187:drug effects*
chemical_list: D011398:Promethazine