SCNN1, an epithelial cell sodium channel gene in the conserved linkage group on mouse chromosome 6 and human chromosome 12.
SCNN1, a gene encoding a nonvoltage-gated sodium channel, was detected using a rat colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse SCNN1 was mapped to a conserved linkage group on distal chromosome 6. The observed order of mouse genes was centromere-Raf1-(2.1 +/- 2.1)-Scnn1, Vwf-(1.9 +/- 1.9)-Ntf3, with 0/101 recombinants between Scnn1 and Vwf. No rearrangements of genomic DNA were detected in the linked mouse mutations deaf waddler (dfw) and opisthotonus (opt).
Meisler
M H
MH
Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618.
Barrow
L L
LL
Canessa
C M
CM
Rossier
B C
BC
D000818:Animals; D002875:Chromosomes; D002881:Chromosomes, Human, Pair 12; D004848:Epithelium / Q000378:metabolism; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D015222:Sodium Channels / Q000235:genetics*
D015222:Sodium Channels