[The comparative efficacy of individually adjusted doses of proxodolol and propranolol for one-time and regular administration in stenocardia patients].
The comparative efficacy of single and regular doses of the new Russian alpha- and beta-adrenoblocker proxodolol (Pd) and the beta-adrenoblocker propranolol (Pr) was studied in 12 male patients with stable angina on effort. The effect of single doses was evaluated with paired bicycle ergometries (PBE); that of course therapy was assessed with crossover randomized placebo-controlled tests of the two agents. During PBE, an adequate antianginal effect of Pd given in single doses of 0.04-0.08 g was seen in 66.5% and that of Pr used in the same doses was observed in 58.4% (p > 0.05). The exercise tolerance in patients given either agent in a single dose was similar. During 1-month course treatment with Pd in a mean daily dose of 186 +/- 24 mg, anginal episodes caused an over 3-fold reduction, which is similar to the clinical effect displayed by Pr, 182 +/- 25 mg/day. A single dose of Pd of 0.04 g produced a more pronounced chronotropic and antihypertensive effect than did the same dose of Pr. No differences were found during their course therapy. Pd was found to cause no orthostatic antihypertensive phenomenon.
Bochkareva
E V
EV
Kokurina
E V
EV
Metelitsa
V I
VI
Pankina
V A
VA
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test / Q000187:drug effects / Q000295:instrumentation / Q000379:methods; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010069:Oxadiazoles / Q000008:administration & dosage* / Q000009:adverse effects; D011433:Propranolol / Q000008:administration & dosage*; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D010069:Oxadiazoles; C088649:proxodolol; D011433:Propranolol
Sravnitel'naia éffektivnost' individual'no podobrannykh doz proksodolola i propranolola u bol'nykh stenokardieĭ pri razovom i reguliarnom prieme.