title: [Basal cell cancer--current research sheds new light].
abstract: Although the aetiology of common skin cancer, basal cell carcinoma (BCC), is unknown, epidemiological findings suggest that, in addition to genetic predisposition, excessive exposure to UV-light, especially in the form of episodes of intensive sunburn, is a crucial aetiological factor. Biologically, BCC may vary from superficial, relatively benign tumours to aggressive infiltrating tumours. Hereditary BCC (Gorlin's syndrome) is most probably caused by inactivation of a tumour suppressor gene on chromosome 9q, and recent findings suggest that this gene may also be involved in common sporadic cases of BCC.
authors.affiliation: Hudkliniken, Karolinska sjukhuset, Stockholm.
authors.forename: M
authors.initials: M
authors.lastname: Ståhle-Bäckdahl
mesh_terms: D002280:Basal Cell Carcinoma / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy
chemical_list: D008666:Metalloendopeptidases
vernacular_title: Basalcellscancer--aktuell forskning ger ny insikt.