Marine natural products. XXXIII. Theonellapeptolide IId, a new tridecapeptide lactone from the Okinawan marine sponge Theonella swinhoei.
Following the characterization of theonellapeptolides Ia-Ie (2-6), another new tridecapeptide lactone named theonellapeptolide IId (1) was isolated from the Okinawan marine sponge Theonella swinhoei. The structure of 1 has been determined on the bases of chemical and physicochemical examinations which included an HPLC-CD combined analysis of the amino acid composition. Theonellapeptolide IId (1) prevented fertilization of the sea urchin Hemicentrotus pulcherrimus at the concentration of 25 micrograms/ml or greater but did not affect early embryonic development of fertilized eggs up to the gastrula stage.
Kobayashi
M
M
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Kanzaki
K
K
Katayama
S
S
Ohashi
K
K
Okada
H
H
Ikegami
S
S
Kitagawa
I
I
D000595:Amino Acid Sequence; D000818:Animals; D005306:Fertilization / Q000187:drug effects; D008969:Molecular Sequence Data; D010063:Ovum / Q000187:drug effects; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D012617:Sea Urchins
D010456:Peptides, Cyclic; C089881:theonellapeptolide IId