title: Effect of topical calcipotriol on congenital ichthyoses.
abstract: We investigated the clinical efficacy of topically applied calcipotriol in six patients with congenital ichthyosis, using a double-blind, bilaterally paired, comparative approach. Unilateral improvement, in favour of the calcipotriol-treated side, was observed in three patients with lamellar ichthyosis. A beneficial response was also observed in a patient with bullous ichthyotic erythroderma of Brocq. No clinical side-effects or laboratory anomalies were observed. This study indicates that calcipotriol constitutes a new and promising approach in alleviating disorders of keratinization characterized by hyperproliferation, other than psoriasis.
authors.affiliation: Department of Dermatology, University Hospital, Nijmegen, The Netherlands.
authors.forename: G P
authors.initials: GP
authors.lastname: Lucker
authors.forename: P C
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: M R
authors.initials: MR
authors.lastname: van Dïjk
authors.forename: P M
authors.initials: PM
authors.lastname: Steijlen
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D005079:Excipients / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012867:Skin / Q000187:drug effects
chemical_list: D003879:Dermatologic Agents; D005079:Excipients; C055085:calcipotriene; D002117:Calcitriol