Is antibiotic treatment of chronic sinusitis effective in children?
A double-blind randomized controlled trial on 79 patients aged between 2 and 12 years with chronic sinusitis showed no significant advantage of adding antibiotics to the treatment by sinus lavage. The prognosis after both 6 and 12 weeks was worse for patients with bilateral opaque sinus radiographs. Half of the Branhanmella catarrhalis cultured in this study were beta-lactamase producing organisms, therefore antibiotics prescribed for this group of children should be chosen bearing this in mind.
Otten
H W
HW
Department of Ear, Nose and Throat Medicine, Academic Hospital, Utrecht, The Netherlands.
Antvelink
J B
JB
Ruyter de Wildt
H
H
Rietema
S J
SJ
Siemelink
R J
RJ
Hordijk
G J
GJ
D002433:Cefaclor / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003352:Corynebacterium / Q000302:isolation & purification; D004311:Double-Blind Method; D004322:Drainage; D005260:Female; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy; D001936:Moraxella catarrhalis / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D013997:Time Factors
D002433:Cefaclor