[Markers of coagulation/fibrinolysis in angitis].
Endothelial cells exhibit antithrombogenic properties, including PGI2 and NO production which inhibit platelet functions and induce blood vessel dilatation. Endothelium also produces thrombomodulin which converts thrombin from a procoagulant protease to an anticoagulant. These antithrombogenic properties are altered by several factors, which include inflammatory cytokines (IL-1, TNF) resulting hypercoagulable state in inflammation. Thus increased markers of coagulation/fibrinolysis were observed in angitis syndrome. The hypercoagulable state showing the activity of angitis may cause thrombosis and may act as a progressive factor for angitis.
Maruyama
I
I
Department of Laboratory Medicine, Kagoshima University School of Medicine.
D001777:Blood Coagulation; D016207:Cytokines / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism; D011464:Epoprostenol / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D009609:Nitrous Oxide / Q000378:metabolism; D018180:Thrombomodulin / Q000378:metabolism / Q000502:physiology; D013927:Thrombosis / Q000209:etiology; D014657:Vasculitis / Q000209:etiology*
D016207:Cytokines; D018180:Thrombomodulin; D011464:Epoprostenol; D009609:Nitrous Oxide