title: [Normalization of left ventricular function and subsequent recurrence of dilatation and pump failure in a patient with hypertensive heart disease in dilated phase after treatment with anthracycline].
abstract: A 71 years old man, ex-smoker, moderate drinker, with a history of diabetes mellitus (type II), moderate arterial hypertension, mild aortic stenosis and moderate uniform left ventricular hypertrophy echographically documented, developed a non Hodgkin low malignancy cavum lymphoma. He has underwent chemotherapy for two years (adriamycin and other chemotherapy drugs) at moderate dosages. A complete remission of the lymphoma followed the treatment, but an initial deterioration of left ventricular function, with heart dilatation and congestive heart failure, was found. The patient improved by medical treatment, returning to the previously stable clinical condition. However a ventricular dilatation reoccurred and a paroxysmal complete atrio-ventricular block developed, necessitating the implantation of a pace maker. The patient died suddenly, during sleep, at home. This is a unique case, because of the numerous cardiac factors associated (chemotherapy and clinical findings). More probably the combination of these multiple factors and their interrelationship could explain the unique non-linear evolution of the left ventricular hypertrophy. In conclusion in these patients a very strict clinical and pharmacological follow up with serial echocardiographical examinations is fundamental and highly recommended.
authors.affiliation: Cardiologia-ARC, Ospedale Civile, Pordenone e Unità di Cardiologia Sperimental, Cro, Aviano.
authors.forename: G
authors.initials: G
authors.lastname: Zottarel
authors.forename: G L
authors.initials: GL
authors.lastname: Nicolosi
authors.forename: C
authors.initials: C
authors.lastname: Lestuzzi
authors.forename: D
authors.initials: D
authors.lastname: Zanuttini
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000150:complications* / Q000175:diagnosis; D004562:Electrocardiography; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000175:diagnosis; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D012008:Recurrence; D016277:Ventricular Function, Left
chemical_list: D000903:Antibiotics, Antineoplastic
vernacular_title: Normalizzazione della funzione ventricolare sinistra e successiva recidiva di dilatazione e deficit di pompa in paziente con cardiopatia ipertensiva in fase dilatativa dopo trattamento con antracicline.