[Early bacterial infections in 103 patients treated with bone marrow transplantation].
OBJECTIVE
To analyse bacterial infections in the period immediately following bone-marrow transplantation.


METHODS
A retrospective study of 174 febrile episodes appearing on 103 patients treated with bone-marrow transplantation in 1990 and 1991 was carried out, special attention being paid to the bacterial infections.


RESULTS
Virtually all patients (100/103) had at least one febrile episode, and its infectious character was documented in 54% of the instances. Gram-positive germs were most commonly present, 85% of the bacteria isolated, and coagulase-negative staphylococci, especially St epidermidis, predominated (60%). Different species of streptococci, mostly of the viridans group, were isolated in 22% of the blood cultures attained in the first febrile episodes. The mortality due to infection in the series as a whole was 4.8%.


CONCLUSIONS
Infections by gram-positive germs, especially coagulase-negative staphylococci, are commonly found among the patients subjected to bone-marrow transplantation. Increased streptococci infections, mostly of the viridans group, are also appreciated. These facts, along with decreased number of gram-negative infections, must be born in mind when designing initial antimicrobial coverage for these patients.
Tomás
J F
JF
Servicio de Hematología, Hospital de la Princesa, Madrid.
Hernández
L M
LM
Peñarrubia
M J
MJ
Figuera
A
A
Jiménez
M L
ML
Cámara
R
R
Arranz
R
R
López
J L
JL
Cruz
J
J
Fernández-Rañada
J M
JM
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D016026:Bone Marrow Transplantation; D002405:Catheterization, Central Venous / Q000009:adverse effects; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications; D015995:Prevalence; D012189:Retrospective Studies
Infecciones bacterianas precoces en 103 pacientes tratados con trasplante de medula ósea.