title: Anti-idiotype antibodies and circulating immune complexes after immunisation with tetanus-toxoid.
abstract: OBJECTIVE
  To determine if anti-idiotype antibodies and circulating immune complexes in individuals before and after immunisation with tetanus toxoid play a role in the immune response.
  
  
  METHODS
  A study of individuals who were administered a single dose of tetanus toxoid (TT) and who were unimmunized.
  
  
  METHODS
  Out patient departments of a large public hospital in Bombay, India.
  
  
  METHODS
  Thirty eight individuals pre-immunisation and forty five individuals post-immunisation with tetanus toxoid, tested at 1, 3, 6, and 12 months.
  
  
  METHODS
  Development of anti-tetanus anti-idiotype antibodies and circulating immune complexes.
  
  
  RESULTS
  Pre-immunisation cases did show presence of anti-tetanus antibodies but in lower titres than post-immunisation up to six months, after which there was a reduction. Specific anti-idiotype antibodies were detected in 19 cases. One and three months after immunisation more cases had high titre antibodies and circulating immune complexes, though after six months, there was a fall in anti-tetanus antibody titres. Circulating immune complexes were seen in those samples having anti-idiotype antibodies.
  
  
  CONCLUSIONS
  Though a significant rise in anti-tetanus antibody anti-idiotype antibodies, protective levels in mice and circulating immune complexes are seen after immunisation with TT it lasts for six months. When followed up for a period of one year it is observed that in cases having auto anti-idiotype antibodies, the anti-tetanus antibodies are maintained for a longer period.
authors.affiliation: Blood Bank KEM Hospital, Poona.
authors.forename: P S
authors.initials: PS
authors.lastname: Kamath
authors.forename: S S
authors.initials: SS
authors.lastname: Badakere
authors.forename: B C
authors.initials: BC
authors.lastname: Mehta
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000187:drug effects* / Q000276:immunology; D000907:Antibodies, Bacterial / Q000097:blood / Q000187:drug effects / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000097:blood / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood / Q000187:drug effects / Q000276:immunology; D013745:Tetanus Toxoid / Q000494:pharmacology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D013745:Tetanus Toxoid