title: Effect of intravenous atrial natriuretic peptide on gas exchange in humans.
abstract: The aim of this work was to establish whether a physiological increase in atrial natriuretic peptide (ANP) plasma levels affects pulmonary gas exchange in humans. Ten volunteers received an infusion of either ANP (4 pmol.kg-1.min-1) or physiological saline, for 60 min. Baseline measures of the alveolar-arterial PO2 difference and of the physiological dead space were within normal limits and remained stable during and after the infusion of ANP or saline, although plasma ANP and cGMP rose significantly (p < 0.01) (mean +/- SEM: ANP: 13.4 +/- 3.9 to 56.0 +/- 10.4 pmol/l; cyclic GMP: 3.8 +/- 0.3 to 17.0 +/- 3.8 nmol/l). We conclude that a physiological increase in plasma ANP does not affect pulmonary gas exchange significantly in humans.
authors.affiliation: Department of Medicine, Hôtel Dieu de Montréal, Québec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Wong
authors.forename: R
authors.initials: R
authors.lastname: Demnati
authors.forename: M C
authors.initials: MC
authors.lastname: Michoud
authors.forename: A
authors.initials: A
authors.lastname: Robichaud
authors.forename: J R
authors.initials: JR
authors.lastname: Cusson
authors.forename: G
authors.initials: G
authors.lastname: Thibault
authors.forename: R
authors.initials: R
authors.lastname: Amyot
authors.forename: P
authors.initials: P
authors.lastname: Hamet
authors.forename: P
authors.initials: P
authors.lastname: Larochelle
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011659:Pulmonary Gas Exchange; D012016:Reference Values; D016037:Single-Blind Method
chemical_list: D009320:Atrial Natriuretic Factor