[Rheumatoid arthritis and the intestinal microbiocenosis].
Intestinal microflora was investigated by fecal bacteriological examination in 175 patients with verified rheumatoid arthritis (RA). Intestinal dysbacteriosis of different stages was detected in 75% of the RA patients on nonsteroid antiinflammatory treatment. The frequency and severity of abnormal biocenosis in RA patients were significantly greater than in subjects with osteoarthritis deformans (p < 0.01) and bronchial asthma patients (p < 0.01). Dysbacteriosis severity increased with growing RA activity (between the groups with the activity stage I and III the difference was significant, p <( 0.05). After the fecal microorganisms inoculation it became evident that RA patients carry, as a rule, Clostridium perfringens. Seven RA patients diagnosed to have dysbacteriosis received adjuvant bactisubtil (dry culture of the strain Bacillus IP 5832). The addition of bactisubtil aggravated the patients' condition, in 4 patients, moreover, the microflora got worse. Explanations of the observations on the direct participation of the intestine in RA pathogenesis are suggested.
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D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D001412:Bacillus subtilis; D001685:Biological Factors / Q000009:adverse effects / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005243:Feces / Q000382:microbiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008875:Middle Aged
D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001685:Biological Factors; D005938:Glucocorticoids; C089800:bactisubtil
Revmatoidnyĭ artrit i mikrobiotsenoz kishechnika.