The treatment of spasticity by intrathecal administration of baclofen: a preliminary personal experience.
The administration of baclofen, a GABAb agonist, by direct infusion into the CSF by means of a programmable device, may avoid the undesired side effects of the oral administration of both the same and other antispastic drugs while giving a marked reduction of spasticity. The preliminary results on 12 patients show the total efficacy of this procedure in reducing spasticity markedly.
Broggi
G
G
Department of Neurosurgery, Istituto Nazionale Neurologico C. Besta, Milan, Italy.
Servello
D
D
Brock
S
S
Dones
I
I
D000328:Adult; D001418:Baclofen / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015918:Infusion Pumps, Implantable; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy*; D015419:Spastic Paraplegia, Hereditary / Q000188:drug therapy*; D013131:Spine
D001418:Baclofen