title: A case-control study of cancer mortality at a transformer-assembly facility.
abstract: To address earlier reports of excess cancer mortality associated with employment at a large transformer manufacturing plant, each plant operation was rated for seven exposures: Pyranol (a mixture of polychlorinated biphenyls and trichlorobenzene), trichloroethylene, benzene, mixed solvents, asbestos, synthetic resins, and machining fluids. Site-specific cancer deaths among active or retired employees were cases; controls were selected from deaths (primarily cardiovascular deaths) presumed to be unassociated with any of the study exposures. Using job records, we then computed person-years of exposure for each subject. All subjects were white males. The only unequivocal association was that of resin systems with lung cancer (odds ratio = 2.2 at 16.6 years of exposure, P = 0.001, in a multiple logistic regression including asbestos, age, year of death, and year of hire). Certain other odds ratios appeared larger, but no other association was so robust and remained as distinct after considering the multiplicity of comparisons. Study power was very limited for most associations, and several biases may have affected our results. Nevertheless, further investigation of synthetic resin systems of the type used in the study plant appears warranted.
authors.affiliation: Department of Epidemiology, UCLA School of Public Health 90024-1772.
authors.forename: S
authors.initials: S
authors.lastname: Greenland
authors.forename: A
authors.initials: A
authors.lastname: Salvan
authors.forename: D H
authors.initials: DH
authors.lastname: Wegman
authors.forename: M F
authors.initials: MF
authors.lastname: Hallock
authors.forename: T J
authors.initials: TJ
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D001194:Asbestos / Q000009:adverse effects / Q000032:analysis; D001554:Benzene / Q000009:adverse effects / Q000032:analysis; D002273:Carcinogens / Q000032:analysis; D002423:Cause of Death; D011211:Electric Power Supplies; D006801:Humans; D007219:Industrial Oils / Q000009:adverse effects / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced / Q000401:mortality*; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D012116:Resins, Plant / Q000009:adverse effects / Q000032:analysis; D012997:Solvents / Q000009:adverse effects / Q000032:analysis; D014241:Trichloroethylene / Q000009:adverse effects / Q000032:analysis
chemical_list: D000395:Air Pollutants, Occupational; D002273:Carcinogens; D012116:Resins, Plant; D012997:Solvents; D001194:Asbestos; D014241:Trichloroethylene; D001554:Benzene