title: Vulvar intraepithelial neoplasia III: a clinical study of the outcome in 113 cases with relation to the later development of invasive vulvar carcinoma.
abstract: OBJECTIVE
  To determine the outcome of 113 women with vulvar intraepithelial neoplasia (VIN), particularly in reference to the later development of invasive vulvar carcinoma.
  
  
  METHODS
  All cases of VIN III seen between 1961 and 1993 were reviewed.
  
  
  RESULTS
  Seven of eight untreated cases of VIN III progressed to invasive vulvar cancer within 8 years, and the eighth regressed spontaneously. Four women developed invasive vulvar carcinoma 7-18 years after treatment. Thus, 3.8% of treated patients later developed invasive vulvar carcinoma, and 87.5% of untreated patients progressed to invasive carcinoma.
  
  
  CONCLUSIONS
  There is a substantial risk that untreated VIN III will progress to invasive cancer.
authors.affiliation: Department of Gynecologic Oncology, Green Lane/National Women's Hospital, Auckland, New Zealand.
authors.forename: R W
authors.initials: RW
authors.lastname: Jones
authors.forename: D M
authors.initials: DM
authors.lastname: Rowan
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012307:Risk Factors; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy