Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets.
The present study aimed at comparing the effects of low concentrations of BPDZ 44, a new pyridothiadiazine derivative, and diazoxide on 86Rb outflow, 45Ca outflow, 45Ca uptake and insulin release from rat pancreatic islets. Both drugs caused similar modifications, but the effects of BPDZ 44 on the cationic and secretory events were much more marked than those of diazoxide. It is suggested that BPDZ 44 could be valuable tool for further studies of the KATP channels.
Antoine
M H
MH
Laboratory of Pharmacology, School of Medicine, Brussels Free University, Belgium.
Pirotte
B
B
Hermann
M
M
de Tullio
P
P
Delarge
J
J
Herchuelz
A
A
Lebrun
P
P
D000818:Animals; D002132:Calcium Radioisotopes / Q000378:metabolism; D002412:Cations; D003981:Diazoxide / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D012414:Rubidium Radioisotopes / Q000378:metabolism; D013829:Thiadiazines / Q000494:pharmacology*
D002132:Calcium Radioisotopes; D002412:Cations; D007328:Insulin; D011725:Pyridines; D012414:Rubidium Radioisotopes; D013829:Thiadiazines; C087201:BPDZ 44; D005947:Glucose; D003981:Diazoxide