Clinical significance of upper airway dysfunction in motor neurone disease.
BACKGROUND
To assess the occurrence, functional characteristics and prognostic value of upper airway dysfunction in motor neurone disease, 27 patients unselected for respiratory symptoms were studied.


METHODS
Upper airway function was evaluated by analysis of the maximal flow-volume loop. Neurological diagnosis was established from the clinical history and physical examination. The degree of impairment was quantified by the Appel score.


RESULTS
Twelve patients (group A) showed abnormalities of the maximal flow-volume loop consistent with flow limitation (seven patients) or instability of upper airway function (gross oscillations of airflow, five patients). The remaining 15 patients (group B) exhibited a normal or generally reduced maximal flow-volume loop, suggestive of muscle weakness. No differences were observed between groups in general physical condition, rate of disease progression, or duration of disease.


CONCLUSIONS
Upper airway dysfunction in patients with motor neurone disease was a frequent finding. It was present more often, but not exclusively, in patients with bulbar features and was unrelated to prognosis.
García-Pachón
E
E
Departament de Pneumologia, Hospital de la Santa Creu i de Sant Pau, Facultat de Medicina, Universitat Autonoma de Barcelona, Spain.
Martí
J
J
Mayos
M
M
Casan
P
P
Sanchis
J
J
D010244:Bulbar Palsy, Progressive / Q000503:physiopathology; D005260:Female; D006801:Humans; D007821:Laryngeal Muscles / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology; D008297:Male; D008449:Maximal Expiratory Flow-Volume Curves; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000503:physiopathology*; D010609:Pharyngeal Muscles / Q000503:physiopathology*; D011379:Prognosis