Role of Bruton's tyrosine kinase in immunodeficiency.
The genetic defect associated with human X-linked agammaglobulinemia and murine X-linked immunodeficiency was recently shown to result from lack of function of a new cytoplasmic tyrosine kinase, called Bruton's tyrosine kinase (Btk). The phenotypes associated with these immunodeficiencies indicate that Btk plays a critical role in B-lymphocyte development. The distinctive protein structure of Btk and preliminary functional studies suggest that Btk may act in a novel manner in a variety of signaling pathways.
Tsukada
S
S
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024-1662.
Rawlings
D J
DJ
Witte
O N
ON
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000361:Agammaglobulinemia / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D008040:Genetic Linkage; D006801:Humans; D051379:Mice; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction; D014960:X Chromosome
D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human; C000625951:Btk protein, mouse