Effect of POMC-derived peptides on corticosterone secretion during the stress hypo-responsive period in rat.
During the stress hyporesponsive period (postnatal days 2-10), the stimulation of corticosterone secretion by ACTH is very low. In our study, we have observed that administration of ACTH during 3 consecutive days is followed by a striking increase in corticosterone response to an acute ACTH test. A comparable potentiation of corticosterone secretion was observed after a similar treatment with Lys gamma 3-MSH. The 3 day-treatment with each peptide induced an increase in adrenal weight. Similar data were obtained with alpha-MSH. However, corticosterone response to ACTH was not significantly altered following the same pattern of alpha-MSH administration.
Oliver
C
C
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Institut Fédératif Jean Roche, Faculté de Médecine Nord, Marseille, France.
Boudouresque
F
F
Lacroix
O
O
Anglade
G
G
Grino
M
M
D000302:Adrenal Cortex / Q000187:drug effects* / Q000254:growth & development; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D003345:Corticosterone / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology*; D011333:Pro-Opiomelanocortin / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013268:Stimulation, Chemical; D013312:Stress, Physiological / Q000503:physiopathology*; D000521:alpha-MSH / Q000494:pharmacology*
D010446:Peptide Fragments; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin; C037670:MSH, Lys-gamma(3); D000324:Adrenocorticotropic Hormone; D003345:Corticosterone