title: Biochemical and genetic analysis of variant C of caprine alpha s2-casein (Capra hircus).
abstract: Two alleles, A and B, were previously described at the goat alpha s2-casein locus. Isoelectric focusing allowed us to subdivide the former one in two new alleles, called A and C. Although alpha s2-casein C cannot actually be distinguished from its A counterpart by starch or polyacrylamide gel electrophoresis, it differs from the previous allele by a single substitution Lys (A)/Ile (C) at position 167, which was confirmed at the nucleotide level. The frequencies of the three alpha s2-casein alleles A, B and C were estimated to be 0.85, 0.04 and 0.11 in the French dairy breeds 'Alpine' and 'Saanen'.
authors.affiliation: Unité de développement concertée INSERM U-310-INRA Station 806, Institut de Biologie Physico-chimique, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bouniol
authors.forename: G
authors.initials: G
authors.lastname: Brignon
authors.forename: M F
authors.initials: MF
authors.lastname: Mahé
authors.forename: C
authors.initials: C
authors.lastname: Printz
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002364:Caseins / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D018076:DNA, Complementary / Q000235:genetics; D005260:Female; D005602:France; D005787:Gene Frequency; D014644:Genetic Variation; D006041:Goats / Q000235:genetics*; D007526:Isoelectric Point; D008297:Male; D008969:Molecular Sequence Data; D010449:Peptide Mapping; D013045:Species Specificity
chemical_list: D002364:Caseins; D018076:DNA, Complementary