Therapeutic prospects of natural alpha interferon from normal human leucocytes in the treatment of genital condylomata in HIV positive women.
Various Authors underline that HIV positive women have a higher CIN incidence and a higher prevalence of HPV. HIV could act as cofactor in the proliferation of HPV manifestation, because of a hypothetical deficit of local immunity. 5 HIV positive patients have been examined: 3 of them presenting vulvocondylomas and/or VIN were treated with 1.000.000 IU alpha IFNn three times a week for three weeks. 2 of them presenting CIN and/or HPV were treated with a two-phase therapy: A) Induction therapy: 3.000.000 IU 3 times a week for three cycles. B) Maintenance therapy: 1.000.000 IU 3 times a week for three months. IFN was the primary treatment for viral lesions, even though an improvement of prognostic indices (CD4, CD4/CDB, 2M), has shown its usefulness in association or in alternative to AZT.
Zarcone
R
R
Gynaecology and Obstetrics Department, Faculty of Medicine and Surgery, University of Naples.
Addonizio
D
D
Voto
R I
RI
Cardone
G
G
Di Stefano
M
M
Cardone
A
A
D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000150:complications / Q000628:therapy* / Q000821:virology; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D027383:Papillomaviridae; D014844:Vulva / Q000821:virology
D016898:Interferon-alpha