Cell surface protein receptors in oral streptococci.
Streptococci have a vast repertoire of adherence properties which include binding to human tissue components, epithelial cells and to other bacterial cells. These interactions are determined by the expression of cell-surface receptors some of which are species-specific. In the oral streptococci, two families of surface protein receptors with highly conserved amino acid sequences have been identified. The antigen I/II family of polypeptides are wall-associated high molecular mass proteins (158-166 kDa) with several binding functions that may be attributed to different domains of the receptor molecules. The LraI family of polypeptides are surface-associated lipoproteins (32-33 kDa) involved in adherence of streptococci to salivary glycoprotein pellicle and to oral Actinomyces. A region of amino acid sequence similarity is evident amongst members of the two protein families in Streptococcus gordonii. Ligand-binding specificities of these receptor polypeptides may account for species-specific adherence and site-directed colonization of streptococci within the human oral cavity.
Jenkinson
H F
HF
Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand.
D018829:Adhesins, Bacterial / Q000032:analysis*; D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000032:analysis*; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis; D001426:Bacterial Proteins / Q000032:analysis*; D002352:Carrier Proteins; D036781:Fimbriae Proteins; D006801:Humans; D008074:Lipoproteins / Q000032:analysis / Q000737:chemistry; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D009055:Mouth / Q000382:microbiology*; D011956:Receptors, Cell Surface / Q000032:analysis*; D016415:Sequence Alignment; D013291:Streptococcus / Q000737:chemistry* / Q000302:isolation & purification
D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D008074:Lipoproteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C085000:PsaA protein, Streptococcus; D011956:Receptors, Cell Surface; C055764:S-layer proteins; C079722:ScaA protein, Streptococcus gordonii; C063055:fimbrillin; C067560:saliva-binding protein, Streptococcus sanguis 12; D036781:Fimbriae Proteins