Pharmacokinetics and pharmacodynamics of rocuronium bromide in adult patients.
In seven patients (M/F: 4:3) rocuronium 0.6 mg kg-1 was given after the induction of anaesthesia with propofol, and during maintenance with N2O/O2, halothane 0.5% and alfentanil 60-90 micrograms kg-1 h-1. Intubation conditions were scored at 60 s and lag time, onset time, maximal block achieved, recovery to 25% of T1, and Recovery Index, were measured using a Relaxograph. Blood samples were taken over a 300 min period and analysed for rocuronium. Intubating conditions at 60 s were excellent in all patients. Mean clearance was 5.2 ml kg-1 min-1, the terminal half-life was 69 min and distribution volume at steady state was 0.22 litre kg-1. Cumulative urinary excretion was around 18% within 24 h.
Alvarez-Gomez
J A
JA
Santa Maria del Rosell Hospital, Cartagena, Spain.
Estelles
M E
ME
Fabregat
J
J
Perez
F
F
Brugger
A J
AJ
D000328:Adult; D000732:Androstanols / Q000493:pharmacokinetics* / Q000494:pharmacology; D000758:Anesthesia; D004576:Electromyography; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics*; D000077123:Rocuronium; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium