title: Imaging of uterine carcinoma by carbon-11-methionine and PET.
abstract: L-[methyl-11C]methionine ([11C]methionine) is probably one of the most useful positron-emitting tracers for metabolic imaging of human cancer. In this study, we investigated whether human uterine cancer can be imaged with [11C]methionine and PET.
  
  
  METHODS
  Fourteen patients with primary uterine malignancy participated in the study. Eight patients had endometrial carcinoma and six had cervical carcinoma. The normal endometrium was analyzed in four additional patients with no uterine malignancy and in one patient with cervical cancer. Tracer uptake was quantitated by calculating both the standardized uptake values (SUVs) and the kinetic influx constants (Ki values) for the tracer.
  
  
  RESULTS
  All patients with either cervical or endometrial carcinoma had increased uptake of [11C]methionine in the PET image. The mean SUV of the carcinomas was 8.4 (n = 13; s.d., 1.5) and the mean Ki was 0.15 min-1 (n = 12; s.d., 0.08 min-1), whereas the mean SUV of the normal endometrium was only 4.6 (n = 5; s.d., 0.8). Histologically poorly (Grade III) or moderately (Grade II) differentiated endometrial carcinomas accumulated more [11C]methionine than the well-differentiated (Grade I) ones (p = 0.04 for the SUVs, and p = 0.05 for the Ki values). There were also variable physiological accumulations of [11C]methionine in the pelvis.
  
  
  CONCLUSIONS
  Uterine carcinoma accumulated [11C]methionine more than the normal endometrium. However, the physiological accumulations of [11C]methionine in the pelvis may confuse the interpreter of the PET image; thus, morphological imaging also needs to be performed as a reference to localize the tumor accurately. We conclude that human uterine carcinoma can be effectively imaged with [11C]methionine and PET.
authors.affiliation: Department of Oncology and Radiotherapy, Turku University, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Lapela
authors.forename: S
authors.initials: S
authors.lastname: Leskinen-Kallio
authors.forename: M
authors.initials: M
authors.lastname: Varpula
authors.forename: S
authors.initials: S
authors.lastname: Grenman
authors.forename: K
authors.initials: K
authors.lastname: Alanen
authors.forename: K
authors.initials: K
authors.lastname: Någren
authors.forename: P
authors.initials: P
authors.lastname: Lehikoinen
authors.forename: U
authors.initials: U
authors.lastname: Ruotsalainen
authors.forename: M
authors.initials: M
authors.lastname: Teräs
authors.forename: H
authors.initials: H
authors.lastname: Joensuu
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D018196:Carcinoma, Adenosquamous / Q000000981:diagnostic imaging*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008715:Methionine; D008875:Middle Aged; D014055:Tomography, Emission-Computed; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging*
chemical_list: C086242:carbon-11 methionine; D008715:Methionine