Effect of intraduodenal infusion of tocamphyl on pancreatic exocrine secretion and gastrointestinal hormone release in rats.
Tocamphyl is a synthetic choleretic that is derived from a root extract of Curcuma longa, L. We investigated the effect of tocamphyl on pancreatic exocrine secretion and bile flow, and on the release of some gastrointestinal hormones, by administering it intraduodenally using anesthetized rats. Tocamphyl stimulated pancreatic exocrine secretion in terms of volume and amylase output in a dose-related manner. Neither a CCK-receptor antagonist, CR1505 (loxiglumide), nor atropine sulfate infused intravenously suppressed the stimulatory effects of tocamphyl on pancreatic exocrine secretion and bile flow. The stimulatory effect on bile flow was stronger than that on pancreatic exocrine secretion. Plasma secretin levels were augmented with the increasing doses of tocamphyl, but CCK levels were not. These results indicate that intraduodenally administered tocamphyl stimulates pancreatic exocrine secretion and bile flow, and suggest that the stimulatory action is, at least in part, mediated by secretin, but not by either CCK or the cholinergic pathway.
Imamura
M
M
Department of Surgery, National Sendai Hospital, Japan.
Yamauchi
H
H
Chey
W Y
WY
D000704:Analysis of Variance; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001646:Bile / Q000187:drug effects; D002164:Camphor / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000494:pharmacology*; D002766:Cholecystokinin / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000096:biosynthesis / Q000378:metabolism*; D008297:Male; D010189:Pancreatic Juice / Q000187:drug effects*; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012633:Secretin / Q000097:blood; D012844:Sincalide
D002756:Cholagogues and Choleretics; D004983:Ethanolamines; D005768:Gastrointestinal Hormones; D012633:Secretin; D002164:Camphor; C053737:loxiglumide; D001285:Atropine; D002766:Cholecystokinin; C074848:Tocamphyl; D011377:Proglumide; D012844:Sincalide