[Comparative study of BCG vaccines: Polish, Danish and Japanese -- laboratory tests].
Three freeze-dried BCG vaccines: Polish, Danish and Japan were compared. It was found, that they fullfill all WHO requirements for freeze-dried BCG vaccine. They were shown to have a high survival of bacilli upon freeze-drying, good viability, thermostability and allergizing properties in guinea pigs. Japan BCG vaccine had especially high viability and thermostability. Mentioned BCG vaccines were safe for guinea pigs even in dose of 5 mg BCG (100 human doses) administrated subcutaneously. It was shown, that Polish BCG vaccine, that is regarded as vaccine of middle strength does not differ essentialy from strong Danish vaccine in respect to viability, thermostability and allergizing properties in guinea pigs evaluated 6 weeks after vaccination.
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Zakład Badania Surowic i Szczepionek Państwowego Zakładu Higieny w Warszawie.
D000818:Animals; D001500:BCG Vaccine / Q000276:immunology* / Q000592:standards*; D003718:Denmark; D006168:Guinea Pigs; D007564:Japan; D011044:Poland; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D001500:BCG Vaccine
Badania porównawcze szczepionek BCG produkcji polskiej, duńskiej i japońskiej--cześć laboratoryja.