Reactivation of phototoxicity test for psoralens plus ultraviolet A by low-dose methotrexate.
Reactivation of a solar burn has been reported after administration of methotrexate for cancer and psoriasis patients. We report a case of psoriasis with a similar but delayed elicitation of phototoxic reaction by administration of low-dose methotrexate one month after psoralen and long-wave ultraviolet light (PUVA) treatment. The reactivation was seen in an already receding phototoxicity test area but not in a less phototoxic, noninterval PUVA treated area, suggesting that the reactivation by methotrexate is related with the severity of light-induced skin inflammation.
Okamoto
H
H
Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
Fukuda
A
A
Mizuno
K
K
Matsuyoshi
N
N
Fujii
K
K
Imamura
S
S
D000368:Aged; D017484:Dermatitis, Phototoxic / Q000209:etiology*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D011701:PUVA Therapy / Q000009:adverse effects; D011565:Psoriasis / Q000188:drug therapy*; D012008:Recurrence; D013471:Sunburn / Q000209:etiology*
D008727:Methotrexate