Gene manipulation and genetic toxicology.
Transgenic mice with recoverable target genes, with genes modified in expression or with ablated gene function provide important tools for defining the biological effects of chemicals. In many cases studies can be conducted with fewer animals and in a shorter timeframe. They also provide important tools for studies of carcinogenesis mechanisms and processes, for early detection of carcinogens and for identification of potential cancer therapies.
Tennant
R W
RW
Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Hansen
L
L
Spalding
J
J
D000818:Animals; D002273:Carcinogens; D005818:Genetic Engineering; D051379:Mice; D008822:Mice, Transgenic; D016296:Mutagenesis; D009153:Mutagens; D009857:Oncogenes / Q000187:drug effects; D012878:Skin Neoplasms / Q000139:chemically induced / Q000235:genetics
D002273:Carcinogens; D009153:Mutagens