title: Forward-looking intravascular ultrasonography: in vitro imaging of normal and atherosclerotic human arteries.
abstract: Inadequate guidance of angioplasty devices limits the endoluminal treatment of high grade atherosclerotic stenoses and total occlusions. Conventional intraluminal ultrasound systems (IVUS) enable lateral cross-sectional imaging of tomographic sections of the vessel wall, but do not offer imaging in front of the catheter. This study describes our initial experience with a forward-looking intravascular ultrasound (FL-IVUS) system (Echoeye, EchoCath, Inc., Princeton, NJ). The acoustic beam from a 25.5 MHz piezoelectric transducer on a 7.5 Fr catheter is mechanically rotated in a forward-looking spiral fashion at 300 cycles/second. Sixty-four axially aligned, cross-sectional, real time images are obtained from a truncated, 60 degree conical volume located 5 to 10 mm from the catheter tip. Luminal dimensions (n = 51) of human cadaveric femoral arteries (cast in agar and submerged in saline) measured by the FL-IVUS were compared to histologic cross-sections of the vessel with a correlation of r = 0.92. FL-IVUS accurately imaged the narrowing lumen in front of total occlusions and the geometry at vessel branches, and identified the location of lesions and the shape and morphology of vessel wall thickness. The 7.5 Fr FL-IVUS over-estimated luminal dimensions in vessels larger than 5 mm. We conclude that FL-IVUS imaging shows promise as a new, accurate method for identifying and characterizing high grade atherosclerotic stenoses and total occlusions, and expands the current capabilities of conventional IVUS systems.
authors.affiliation: Department of Surgery, Harbor-UCLA Medical Center, Torrance 905096-9823.
authors.forename: M R
authors.initials: MR
authors.lastname: Back
authors.forename: G E
authors.initials: GE
authors.lastname: Kopchok
authors.forename: R A
authors.initials: RA
authors.lastname: White
authors.forename: M
authors.initials: M
authors.lastname: Scoccianti
authors.forename: C E
authors.initials: CE
authors.lastname: Donayre
authors.forename: H
authors.initials: H
authors.lastname: Maeuser
authors.forename: B
authors.initials: B
authors.lastname: Brener
mesh_terms: D000800:Angioplasty, Balloon / Q000379:methods; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014159:Transducers; D018084:Ultrasonography, Interventional / Q000295:instrumentation / Q000379:methods*