title: Stimulated parotid salivary flow rates in normotensive, hypertensive, and hydrochlorothiazide-medicated.
abstract: Stimulated parotid salivary flow rates were compared in elderly normotensive, hypertensive, and controlled hypertensive African-Americans, the latter group taking hydrochlorothiazide (HCTZ). The normotensive group consisted of 15 healthy unmedicated subjects with systolic blood pressures of less than 150 mm Hg and diastolic pressures less than 90 mm Hg. The hypertensive group consisted of 10 unmedicated subjects with systolic pressures greater than 160 mm Hg and diastolic pressures greater than 100 mm Hg. The controlled hypertensive group consisted of 20 subjects taking HCTZ (50 mg, daily) with controlled blood pressures similar to the normotensive control group. Stimulated parotid salivary samples were collected from each subject. A 2% citrate solution applied to the dorsum of the tongue was used for stimulation. The results showed no significant differences in stimulated parotid flow rates between normotensive and uncontrolled hypertensive subjects. However, the medicated, controlled hypertensive subjects had a significant reduction of stimulated parotid salivary flow rates compared to both the normotensive and hypertensive groups.
authors.affiliation: EODFF/NIDR/NIH, Bethesda, MD 20892.
authors.forename: C F
authors.initials: CF
authors.lastname: Streckfus
authors.forename: A J
authors.initials: AJ
authors.lastname: Wu
authors.forename: J A
authors.initials: JA
authors.lastname: Ship
authors.forename: L J
authors.initials: LJ
authors.lastname: Brown
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015142:Baltimore; D044383:Black People; D016022:Case-Control Studies; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D004573:Electrolytes / Q000032:analysis; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D007071:Immunoglobulin A, Secretory; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012472:Salivation / Q000187:drug effects*; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D001741:Black or African American
chemical_list: D002951:Citrates; D004573:Electrolytes; D007071:Immunoglobulin A, Secretory; D012471:Salivary Proteins and Peptides; D006852:Hydrochlorothiazide; D019343:Citric Acid