title: 20 alpha-hydroxysteroid dehydrogenase activity in canine spontaneous neoplasms.
abstract: 20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) activities in 57 neoplastic tissues surgically removed from dogs were measured. Forty-eight of 57 tumor samples were shown to possess 20 alpha-HSD activity. These tissues were histopathologically classified into 22 benign and 26 malignant tumors. Among these tumors, mixed tumor types demonstrated the higher 20 alpha-HSD activity than epithelial and non-epithelial types, and malignant tumors of each tissue type showed slightly but not significantly higher 20 alpha-HSD activities comparing with the corresponding benign ones. Comparing with the activity of normal tissues examined, the corresponding tumor tissues showed significantly higher 20 alpha-HSD activities. Thus, 20 alpha-HSD activity was found in neoplastic tissues at a considerable high rate and the activity seemed to be higher in pathologically malignant tumors.
authors.affiliation: Department of Veterinary Surgery, University of Tokyo, Japan.
authors.forename: N M
authors.initials: NM
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Shiota
authors.forename: K
authors.initials: K
authors.lastname: Noda
authors.forename: S
authors.initials: S
authors.lastname: Kokubo
authors.forename: T
authors.initials: T
authors.lastname: Kadosawa
authors.forename: R
authors.initials: R
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
mesh_terms: D015089:20-Hydroxysteroid Dehydrogenases / Q000032:analysis*; D043607:20-alpha-Hydroxysteroid Dehydrogenase; D000818:Animals; D001005:Anus Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D008113:Liver Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000201:enzymology / Q000473:pathology; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary; D012878:Skin Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary; D013736:Testicular Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary
chemical_list: D015089:20-Hydroxysteroid Dehydrogenases; D043607:20-alpha-Hydroxysteroid Dehydrogenase