title: Obstetrical and gynecological complications in fragile X carriers: a multicenter study.
abstract: We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.
authors.affiliation: Greenwood Genetic Center, South Carolina 29646.
authors.forename: C E
authors.initials: CE
authors.lastname: Schwartz
authors.forename: J
authors.initials: J
authors.lastname: Dean
authors.forename: P N
authors.initials: PN
authors.lastname: Howard-Peebles
authors.forename: M
authors.initials: M
authors.lastname: Bugge
authors.forename: M
authors.initials: M
authors.lastname: Mikkelsen
authors.forename: N
authors.initials: N
authors.lastname: Tommerup
authors.forename: C
authors.initials: C
authors.lastname: Hull
authors.forename: R
authors.initials: R
authors.lastname: Hagerman
authors.forename: J J
authors.initials: JJ
authors.lastname: Holden
authors.forename: R E
authors.initials: RE
authors.lastname: Stevenson
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D003120:Colorado; D004252:DNA Mutational Analysis; D003718:Denmark; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008594:Menopause, Premature / Q000235:genetics*; D008599:Menstruation Disturbances / Q000209:etiology* / Q000235:genetics; D009154:Mutation; D009864:Ontario; D009867:Oogonia / Q000502:physiology; D011247:Pregnancy; D012091:Repetitive Sequences, Nucleic Acid; D018570:Risk Assessment; D013022:South Carolina; D014768:Virginia