Suppression of development of glomerulonephritis in NZB x NZWF1 mice by persistent infection with lactic dehydrogenase virus: relations between intercellular adhesion molecule-1 expression on endothelial cells and leucocyte accumulation in glomeruli.
The development of glomerulonephritis (GN) in autoimmune NZB x NZWF1 mice was suppressed by persistent lactic dehydrogenase virus (LDV) infection. In this study the expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells in glomeruli was examined during the development of GN. ICAM-1 expression on endothelial cells preceded the accumulation of leucocytes within glomeruli. The uninfected mice exhibited an age-related and profound increase in ICAM-1 expression associated with the development of a GN as evidenced by deposits of IgG and C3. Uninfected mice also showed increased accumulation of leucocytes, such as polymorphonuclear leucocytes (PMNs), macrophages, T and CD4+ cells, which express the lymphocyte function-associated antigen-1 (LFA-1) within glomeruli during the development of GN. These changes were strongly suppressed by LDV infection. Our findings suggest that the expression of ICAM-1 in glomerular endothelial cells may, at least in part, contribute to the development of GN. Suppressed expression of ICAM-1 in LDV-infected mice may be responsible for the suppression of GN seen in these animals. Thus there may be a pathogenetic role for ICAM-1 expression and for intraglomerular accumulation of leucocytes, especially PMNs, which express LFA-1 in the development of GN.
Kameyama
Y
Y
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan.
Hayashi
T
T
D000818:Animals; D018174:Arterivirus Infections / Q000150:complications* / Q000401:mortality; D001806:Blood Urea Nitrogen; D004727:Endothelium / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology / Q000401:mortality; D006168:Guinea Pigs; D007105:Immune Complex Diseases / Q000150:complications* / Q000276:immunology / Q000401:mortality; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism; D007772:Lactate dehydrogenase-elevating virus; D007962:Leukocytes / Q000502:physiology; D051379:Mice; D008814:Mice, Inbred NZB
D018799:Intercellular Adhesion Molecule-1