title: Alpha 1-antichymotrypsin and IL-1 beta are not increased in CSF or serum in Alzheimer's disease.
abstract: Chronic inflammation associated with the amyloid plaques may represent an acute phase response in the brain. We quantitated the levels of two inflammatory markers; alpha 1-antichymotrypsin (alpha 1-ACT) and interleukin 1 beta (IL-1 beta) in paired serum and cerebrospinal fluid (CSF) samples from 40 patients with Alzheimer's disease (AD), 20 patients with Parkinson's disease (PD), and 42 age-matched controls. No differences in serum or CSF levels of either alpha 1-ACT or IL-1 beta were found between the groups. However, some AD patients had increased alpha 1-ACT index, suggesting an intrathecal production of alpha 1-ACT. Although alpha 1-ACT or IL-1 beta might be involved in the pathogenesis of AD, our results show that their measurement in serum or CSF is not valuable to support the clinical diagnosis of AD.
authors.affiliation: Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314.
authors.forename: T
authors.initials: T
authors.lastname: Pirttila
authors.forename: P D
authors.initials: PD
authors.lastname: Mehta
authors.forename: H
authors.initials: H
authors.lastname: Frey
authors.forename: H M
authors.initials: HM
authors.lastname: Wisniewski
mesh_terms: D000368:Aged; D000418:Albumins / Q000134:cerebrospinal fluid / Q000378:metabolism; D000544:Alzheimer Disease / Q000097:blood* / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D000514:alpha 1-Antichymotrypsin / Q000097:blood* / Q000134:cerebrospinal fluid*
chemical_list: D000418:Albumins; D015415:Biomarkers; D007375:Interleukin-1; D000514:alpha 1-Antichymotrypsin