A randomized, double-blind, placebo-controlled study of luteal phase dydrogesterone (Duphaston) in women with minimal to mild endometriosis.
OBJECTIVE
To compare dydrogesterone with placebos in the treatment of minimal to mild endometriosis.


METHODS
Prospective, double-blind, randomized study.


METHODS
Three Obstetrics and Gynaecology Departments in the United Kingdom.


METHODS
Sixty-two premenopausal women with complaints of pain (n = 12) and infertility with or without pain (n = 50) with minimal to mild endometriosis diagnosed at laparoscopy. Thirty-nine women had a laparoscopy after treatment and 56 women were followed up 12 months after treatment.


METHODS
Two high doses of dydrogesterone (either 40 or 60 mg) or a placebo, which was given for 12 days, beginning 2 days after the LH surge for a treatment period of 6 months.


METHODS
Change between before and after treatment endometriosis scores, pregnancy rates (PRs), and pain.


RESULTS
Treatment with dydrogesterone did not alter the natural history of endometriosis or PRs when compared with placebo. Pain was reduced significantly during treatment with 60 mg dydrogesterone and this improvement still was evident at 12-month follow-up.


CONCLUSIONS
Luteal phase dydrogesterone reduces pain associated with endometriosis.
Overton
C E
CE
John Radcliffe Hospital, Oxford, United Kingdom.
Lindsay
P C
PC
Johal
B
B
Collins
S A
SA
Siddle
N C
NC
Shaw
R W
RW
Barlow
D H
DH
D000328:Adult; D004311:Double-Blind Method; D004394:Dydrogesterone / Q000008:administration & dosage* / Q000627:therapeutic use; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D008183:Luteal Phase; D017699:Pelvic Pain / Q000209:etiology; D010919:Placebos; D011247:Pregnancy
D010919:Placebos; D004394:Dydrogesterone