[An investigation of factors in the pathogenesis of experimental autoimmune uveoretinitis (EAU) in congenic mice].
S-antigen or interphotoreceptor retinoid-binding protein (IRBP), when injected with Freund's complete adjuvant into mice, does not easily cause experimental autoimmune uveoretinitis (EAU). In this report, we describe the results of injecting IRBP with Freund's complete adjuvant, together with the intraperitoneal administration of Bordetella pertussis, into several types of congenic mice (B10, B10A, B10BR, B10D2). These congenic mice, of C57BL/10 (B10) origin, differ at the H-2 locus on chromosome 17. We were able to produce EAU in 38.5% of B10A mice, and 12.5% of B10BR mice, confirming that EAU can develop in these mice that carry the k genotype at the K, I-A, and I-E regions of the major histocompatibility complex (MHC) H-2 locus. We believe that the k genotype of the K, I-A, and I-E regions is important as a factor in the pathogenesis of EAU in congenic B10 mice.
Yamakawa
N
N
Department of Ophthalmology, Tokyo Medical College, Japan.
Tanaka
T
T
Hijikata
S
S
Konoeda
Y
Y
Usui
M
M
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology*; D005136:Eye Proteins; D005620:Freund's Adjuvant; D005838:Genotype; D006239:Haplotypes; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D012173:Retinitis / Q000209:etiology*; D012177:Retinol-Binding Proteins; D014605:Uveitis / Q000209:etiology*; D000099214:Retinol-Binding Proteins, Interstitial
D005136:Eye Proteins; D005620:Freund's Adjuvant; D012177:Retinol-Binding Proteins; D000099214:Retinol-Binding Proteins, Interstitial