The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia.
The ability of the selective metabotropic glutamate receptor (mGluR) antagonist alpha-methyl-4-carboxyphenylglycine (MCPG) to protect hippocampal CA1 neurons from a hypoxic/hypoglycemic injury was examined. Rat hippocampal slices were exposed to a 4 min hypoxia/hypoglycemia, and the recovery of evoked population spikes was monitored. 500 microM (+)-MCPG exhibited a statistically significant protective effect, whereas the (-)-isomer was ineffective. These data suggest that MCPG-sensitive mGluRs may contribute to hypoxia/hypoglycemia-induced injury in rat hippocampal slices.
Opitz
T
T
Institute for Neurobiology, Department of Neurophysiology, Magdeburg, Germany.
Richter
P
P
Reymann
K G
KG
D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D007003:Hypoglycemia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects; D013237:Stereoisomerism
D001565:Benzoates; D018094:Receptors, Metabotropic Glutamate; C079694:alpha-methyl-4-carboxyphenylglycine; D005947:Glucose; D005998:Glycine