[Erythrocyte membrane during shock stage in burned rats].
The anion transport property is the one of the most important functions of the erythrocyte. In this paper a new method is used to measure the NO2- and Cl- ions transport across the erythrocyte membrane in burned rats. It was found that the NO2- and Cl- transport rate across erythrocyte membrane became slower during shock stage in burned rats, being contrary to the results found in heat-treated erythrocytes in vitro. By using a specific inhibitor of anion transport, DIDS, it was shown that the abnormality of NO2- transport across the erythrocyte membrane in burned rats is due probably to a damage of extracellular domain of band 3 protein. The authors consider that the influence of membranotoxic factors and the disturbance of energy metabolism during burn shock stage are accounted for all the noticed alterations.
Meng
F
F
Burn Center, Changhai Hospital, Second Military Medical University of PLA, Shanghai.
Chen
Y
Y
Ge
S
S
D000818:Animals; D000838:Anions / Q000378:metabolism; D002056:Burns / Q000097:blood*; D002463:Cell Membrane Permeability; D002712:Chlorides / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism*; D008297:Male; D017672:Nitrogen Compounds / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012774:Shock, Traumatic / Q000097:blood*
D000838:Anions; D002712:Chlorides; D017672:Nitrogen Compounds