Levodopa failure in chronic manganism.
We report a placebo-controlled study of levodopa in four patients with extrapyramidal deficits caused by chronic manganese intoxication. Their parkinsonism and dystonia had progressed slowly over a period of 5 years after they left the site of exposure. Initially the patients appeared to respond to levodopa in open observations, but this apparent benefit was not sustained. This short-term, double-blind study indicates that their parkinsonism and dystonia failed to respond to levodopa.
Lu
C S
CS
Department of Neurology, Chang Gung Medical College and Memorial Hospital, Taipei, Taiwan.
Huang
C C
CC
Chu
N S
NS
Calne
D B
DB
D000328:Adult; D002908:Chronic Disease; D004311:Double-Blind Method; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D020149:Manganese Poisoning; D008875:Middle Aged; D009069:Movement Disorders / Q000188:drug therapy* / Q000209:etiology*; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D010919:Placebos
D010919:Placebos; D007980:Levodopa