title: Levodopa failure in chronic manganism.
abstract: We report a placebo-controlled study of levodopa in four patients with extrapyramidal deficits caused by chronic manganese intoxication. Their parkinsonism and dystonia had progressed slowly over a period of 5 years after they left the site of exposure. Initially the patients appeared to respond to levodopa in open observations, but this apparent benefit was not sustained. This short-term, double-blind study indicates that their parkinsonism and dystonia failed to respond to levodopa.
authors.affiliation: Department of Neurology, Chang Gung Medical College and Memorial Hospital, Taipei, Taiwan.
authors.forename: C S
authors.initials: CS
authors.lastname: Lu
authors.forename: C C
authors.initials: CC
authors.lastname: Huang
authors.forename: N S
authors.initials: NS
authors.lastname: Chu
authors.forename: D B
authors.initials: DB
authors.lastname: Calne
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004311:Double-Blind Method; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D020149:Manganese Poisoning; D008875:Middle Aged; D009069:Movement Disorders / Q000188:drug therapy* / Q000209:etiology*; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D010919:Placebos
chemical_list: D010919:Placebos; D007980:Levodopa