Amino acid-induced responses in CNS neurons of normal mouse and Wriggle Mouse Sagami.
Amino acid-induced responses and their regional heterogeneities in the motor cortical and hippocampal (CA1) neurons of normal mouse and Wriggle Mouse Sagami (WMS) were studied by conventional patch-clamp techniques. There were no differences in the current densities and EC50s of glutamate-, gamma-amino butyric acid (GABA)-, and glycine-induced responses between the two groups of mice. In both types of mice, the GABA-induced current density of cortical neurones was higher and EC50 was lower than in hippocampal neurones, whereas the responses induced by glycine and glutamate did not show any differences.
Furukawa
K
K
Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan.
Abe
Y
Y
Osawa
N
N
Ohmura
M
M
Akaike
N
N
D000818:Animals; D018698:Glutamic Acid / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008818:Mice, Neurologic Mutants; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D013045:Species Specificity; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D005998:Glycine