[Hepatic toxicity of drugs].
This review deals in its first part with the hepatic mechanisms of drug detoxification and toxification as well as with the physiopathological mechanisms of drug-induced liver diseases. In the second part, the clinical and biological pictures of drug-induced pathological lesions are reviewed. Any liver abnormality should alert the clinician towards a possible toxic aetiology so that the risk of fulminant, eventually lethal, or of severe chronic liver disease can be avoided.
Adler
M
M
Service médico-chirurgical d'Hépato-Gastro-entérologie, Hôpital Erasme, Bruxelles.
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects*; D008113:Liver Neoplasms / Q000139:chemically induced; D004364:Pharmaceutical Preparations / Q000378:metabolism
D004364:Pharmaceutical Preparations
Toxicité hépatique des médicaments.