A-kinase anchoring proteins: a key to selective activation of cAMP-responsive events?
The cAMP-dependent protein kinase (PKA) regulates a variety of diverse biochemical events through the phosphorylation of target proteins. Because PKA is a multifunctional enzyme with a broad substrate specificity, its compartmentalization may be a key regulatory event in controlling which particular target substrates are phosphorylated. In recent years it has been demonstrated that differential localization of the type II holoenzyme is directed through interaction of the regulatory subunit (RII) with a family of A-Kinase Anchoring Proteins (AKAPs). In this report, we review evidence for PKA compartmentalization and discuss the structural and functional properties of AKAPs.
Coghlan
V M
VM
Vollum Institute of Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201.
Bergeson
S E
SE
Langeberg
L
L
Nilaver
G
G
Scott
J D
JD
D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D000242:Cyclic AMP / Q000502:physiology*; D054746:Cyclic AMP-Dependent Protein Kinase Type II; D017868:Cyclic AMP-Dependent Protein Kinases / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D004789:Enzyme Activation; D006706:Homeostasis; D006728:Hormones / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011506:Proteins / Q000378:metabolism*; D013379:Substrate Specificity
D006728:Hormones; D007527:Isoenzymes; D046911:Macromolecular Substances; D011506:Proteins; D000242:Cyclic AMP; D054746:Cyclic AMP-Dependent Protein Kinase Type II; D017868:Cyclic AMP-Dependent Protein Kinases