title: Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
authors.affiliation: University of Texas, Houston.
authors.forename: F
authors.initials: F
authors.lastname: Serino
authors.forename: J
authors.initials: J
authors.lastname: Grevel
authors.forename: K L
authors.initials: KL
authors.lastname: Napoli
authors.forename: B D
authors.initials: BD
authors.lastname: Kahan
authors.forename: H W
authors.initials: HW
authors.lastname: Strobel
mesh_terms: D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology; D016572:Cyclosporine / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D004790:Enzyme Induction; D016166:Free Radical Scavengers / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016166:Free Radical Scavengers; D000632:Aminopyrine; D009249:NADP; D002701:Chloramphenicol; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System; D011335:Proadifen; D007654:Ketoconazole; D010634:Phenobarbital