Signal transduction in hypertension: Part II.
Essential hypertension is characterized by various cell membrane abnormalities associated with receptor characteristics, enzymatic activity, and transmembrane ion exchange. These processes are interrelated with cellular signal transduction. Defects in the tightly controlled intracellular signaling pathways and their implications in the pathogenesis of hypertension are reviewed.
Touyz
R M
RM
Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada.
Schiffrin
E L
EL
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology