title: Two cases of acute myocardial infarction associated with aplastic anemia during treatment with anabolic steroids.
abstract: Thrombosis is a rare complication in patients with aplastic anemia because of the presence of coincidental thrombocytopenia. We have recently treated two cases, a 61-year-old male and a 59-year-old female, with acute myocardial infarction associated with aplastic anemia. Although their platelet counts were lower than normal in spite of treatment with anabolic steroids for aplastic anemia, the coronary angiographic findings strongly suggested coronary thrombosis in both cases. Anabolic steroids, which have been commonly used for the treatment of aplastic anemia, are a possible risk factor for coronary thrombosis because they have an accelerating effect on thrombus formation. We report two very rare but clinically important cases.
authors.affiliation: Department of Internal Medicine, University of Tsukuba, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Toyama
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Iida
authors.forename: S
authors.initials: S
authors.lastname: Koseki
authors.forename: I
authors.initials: I
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Sugishita
mesh_terms: D045930:Anabolic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000188:drug therapy*; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000139:chemically induced / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced*; D012008:Recurrence
chemical_list: D045930:Anabolic Agents