title: [The dependence of the biological activity of metal complexes on the structural stability of the initial DNA].
abstract: The authors have formulated the basic principles of the creation of metallo-constructions with DNA which possess biological activity. Thus, the interaction of metal and DNA during formation of metallo-construction must not destabilize the structure of initial DNA. The studies conducted by the authors prove the hypothesis of the working mechanism of these complexes: pronounced activity against viruses which contain DNA and RNA.
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Vaĭnberg
authors.forename: D N
authors.initials: DN
authors.lastname: Nosik
authors.forename: E N
authors.initials: EN
authors.lastname: Kaplina
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002478:Cells, Cultured; D004247:DNA / Q000737:chemistry* / Q000494:pharmacology; D003864:Depression, Chemical; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D009942:Organometallic Compounds; D004247:DNA
vernacular_title: Zavisimost' biologicheskoĭ aktivnosti metallokompleksov ot stabil'nosti struktury iskhodnoĭ DNK.