The B-cell antigen receptor complex: structure and signal transduction.
The specificity of the immune response is determined by the interaction between the B-cell receptor (BCR) and its cognate structure, antigen. Recent studies have provided considerable insight into the compartmentalization of function within this extremely versatile hetero-oligomeric receptor complex. In this article, Christopher Pleiman, Daniele D'Ambrosio and John Cambier consolidate new findings regarding BCR structure and signal transduction.
Pleiman
C M
CM
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80220.
D'Ambrosio
D
D
Cambier
J C
JC
D000595:Amino Acid Sequence; D000818:Animals; D004792:Enzyme Precursors / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000737:chemistry / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D000072377:Syk Kinase
D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase