Epidermal growth factor--induced implantation and decidualization in the rat.
Effects of epidermal growth factor (EGF) on blastocyst implantation and experimentally-induced decidualization were examined in the rat. Intraluminal injection of EGF into each uterine horn induced implantation in the ovariectomized progesterone-treated delayed implanting rat in a dose-dependent manner. This induction was inhibited by indomethacin, an inhibitor of prostaglandin synthesis. Intraluminal injection of EGF on day 5 of pseudopregnancy elicited a greater decidual response when compared to the vehicle-injected contralateral uterine horn. These results suggest that EGF may play important roles in the process of implantation and decidualization in the rat.
Tamada
H
H
Department of Animal Reproduction, College of Agriculture, University of Osaka Prefecture, Japan.
Kai
Y
Y
Mori
J
J
D000818:Animals; D003656:Decidua / Q000033:anatomy & histology / Q000254:growth & development*; D004305:Dose-Response Relationship, Drug; D010065:Embryo Implantation, Delayed / Q000187:drug effects*; D004622:Embryo, Mammalian / Q000033:anatomy & histology / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
D004815:Epidermal Growth Factor; D007213:Indomethacin