[Interaction of 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine and platelet activating factor with blood and tumor cells].
The effects of the platelet-activating factor (PAF) and the methoxy-PAF analog, 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine, on platelet activation, oxidative burst in neutrophils and proliferation of K-562 and P815 cells have been studied. It has been found that the biological activity of methoxy-PAF for human platelets and neutrophils is commensurate with that of PAF. However, the cytotoxic properties of methoxy-PAF are much stronger than the cytotoxicity of PAF for tumour cells. It is concluded that the biological activity of methoxy-PAF is, to a great extent, due to its close structural resemblance to PAF as well as to the inability of cells to perform rapid metabolism of methoxy-PAF.
Muzia
G I
GI
Orlov
S M
SM
Berdyshev
E V
EV
Kulikov
V I
VI
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D049832:Decapodiformes; D006801:Humans; D051379:Mice; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D010713:Phosphatidylcholines; D010972:Platelet Activating Factor
Vzaimodeĭstvie 1-O-alkil-2-metoksi-sn-glitsero-3-fosfokholina i faktora aktivatsii trombotsitov s kletkami krovi i opukholevymi kletkami.