title: The effect of topical ceftazidime on pseudomonas keratitis in rabbits.
abstract: Ceftazidime is a beta-lactam antibiotic highly effective against Pseudomonas aeruginosa infection. Using a rabbit model of Pseudomonas keratitis, 10(3) bacteria (in 20 microliters) were injected unilaterally into the corneal stroma of albino rabbits. Twenty-six hours after inoculation, topical Ceftazidime (50 mg/ml) drops were administered for 48 h, following which the corneal tissue was cultured. Eighteen of 20 corneal cultures (90%) from rabbits treated with Ceftazidime drops were negative. In comparison, all untreated control group cultures showed florid bacterial growth. These results suggest that topical Ceftazidime may be a useful agent in the treatment of P. aeruginosa keratitis.
authors.affiliation: Department of Ophthalmology, Beilinson Medical Center, Petah Tiqva, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Kremer
authors.forename: A
authors.initials: A
authors.lastname: Robinson
authors.forename: M
authors.initials: M
authors.lastname: Braffman
authors.forename: M
authors.initials: M
authors.lastname: Drucker
authors.forename: M
authors.initials: M
authors.lastname: Goldenfeld
authors.forename: Z
authors.initials: Z
authors.lastname: Samra
authors.forename: N
authors.initials: N
authors.lastname: Myszne-Daye
authors.forename: D
authors.initials: D
authors.lastname: Gaton
authors.forename: H
authors.initials: H
authors.lastname: Savir
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002442:Ceftazidime / Q000008:administration & dosage / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology; D009883:Ophthalmic Solutions; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D011817:Rabbits
chemical_list: D009883:Ophthalmic Solutions; D002442:Ceftazidime