title: Congenital varicella syndrome: studies of the virus-specific humoral and cell-mediated immune responses.
abstract: We describe a three-year-old boy with congenital varicella syndrome. Persistent IgG antibodies to varicella-zoster virus (VZV) were detected in the child's sera for a period of more than three years. Immunological studies performed at three months and at three years of age showed a VZV-specific cellular immune response. The results suggest that intrauterine VZV infections in early pregnancy can induce adequate humoral and cellular immune reactions in the infected foetus.
authors.affiliation: Department of Paediatrics, University Hospital, Würzburg, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Schuster
authors.forename: G
authors.initials: G
authors.lastname: Hofmann
authors.forename: J
authors.initials: J
authors.lastname: Pannenbecker
authors.forename: H W
authors.initials: HW
authors.lastname: Kreth
mesh_terms: D000009:Abdominal Muscles / Q000002:abnormalities*; D000015:Abnormalities, Multiple; D000293:Adolescent; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation / Q000276:immunology; D002644:Chickenpox / Q000097:blood / Q000150:complications / Q000151:congenital* / Q000276:immunology* / Q000635:transmission; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005532:Foot Deformities, Congenital / Q000150:complications*; D006228:Hand Deformities, Congenital / Q000150:complications*; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006732:Horner Syndrome / Q000150:complications*; D006801:Humans; D006849:Hydrocephalus / Q000150:complications*; D007111:Immunity, Cellular / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood*; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D013577:Syndrome
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G