title: Hepatic encephalopathy with increased cerebral blood flow in SPECT and MRI abnormalities in the basal ganglia.
abstract: A case of hepatic encephalopathy with increased cerebral blood flow in single-photon emission computed tomography (SPECT) and abnormalities upon magnetic resonance imaging (MRI) is reported. SPECT showed increased blood flow exceeding 70 ml/100 g/min in the cerebellum, basal ganglia and cerebral cortex, with hyperammonemia and abnormal electroencephalographic signs showing severe generalized slowing. SPECT data and MRI might reflect abnormal metabolism and neuropathological changes in hepatic encephalopathy.
authors.affiliation: Department of Neurology, Okayama University Medical School, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kohira
authors.forename: E
authors.initials: E
authors.lastname: Matsuo
authors.forename: Y
authors.initials: Y
authors.lastname: Shiro
authors.forename: N
authors.initials: N
authors.lastname: Uemura
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Ishizu
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: S
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001479:Basal Ganglia / Q000098:blood supply / Q000473:pathology; D001480:Basal Ganglia Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D002531:Cerebellum / Q000098:blood supply / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D005260:Female; D006501:Hepatic Encephalopathy / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D012021:Reflex, Abnormal / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000978:Antiparkinson Agents