Allogeneic marrow transplantation for myelodysplastic syndrome complicating autologous bone marrow transplantation.
A patient with refractory relapsed Hodgkin's disease underwent an autologous bone marrow transplant in July 1987 and achieved remission of Hodgkin's disease. He had complete hematological recovery but developed pancytopenia 3 years post bone marrow transplantation with morphological evidence of myelodysplasia. High-dose cyclophosphamide, 200 mg/kg, chemotherapy followed by an allogeneic bone marrow transplant from a HLA-matched sibling was performed in April 1991 with complete hematological recovery. Allogeneic bone marrow transplantation was thus used successfully to treat a potential complication of autologous bone marrow transplantation.
Bashir
S
S
Department of Medicine, New York Medical College, Valhalla 10595.
Cook
P
P
Katz
M
M
Mittelman
A
A
Ahmed
T
T
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000628:therapy*; D010198:Pancytopenia / Q000209:etiology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D003520:Cyclophosphamide