Effect of acute ventricular pressure changes on QRS duration.
The effect of acute changes in ventricular pressure is examined on the QRS duration to clarify the mechanism of ventricular pressure-related arrhythmogenesis. Ventricular pressure was changed acutely by arterial transfusion-bleeding into an open-air ventricular pressure reservoir that was either off or on a metaraminol intravenous drip. While maintaining ventricular pressure at several levels, the QRS duration was measured at 200 mm/s paper speed. The QRS duration correlated significantly with the left ventricular pressure in all 14 dogs examined. An average change in ventricular by 100 mmHg was associated with a change of about 18% in the QRS duration. An acute ventricular pressure elevation impairs the ventricular conduction, which may contribute to ventricular pressure-related arrhythmogenicity.
Sideris
D A
DA
Department of Clinical Therapeutics, Medical School of Athens University, Ioannina, Greece.
Toumanidis
S T
ST
Kostopoulos
K
K
Pittaras
A
A
Spyropoulos
G S
GS
Kostis
E B
EB
Moulopoulos
S D
SD
D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001810:Blood Volume; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D007262:Infusions, Intravenous; D008680:Metaraminol / Q000008:administration & dosage / Q000494:pharmacology; D012044:Regression Analysis; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D017725:Ventricular Pressure / Q000187:drug effects / Q000502:physiology*
D008680:Metaraminol