title: Modulation of cell-mediated immunity by lithium chloride.
abstract: Immunomodulation of cell-mediated immunity was studied in mice treated with either lithium chloride (LiCl), anti-CD8 monoclonal antibody or their combination. While 6-day LiCl treatment decreased the ability of their splenocytes to induce a local graft-versus-host reaction--anti-CD8 abolished this effect. The proliferative response of spleen cells from those three groups of mice to concanavalin A stimulation in vitro was significantly increased. The natural killer (NK) cell toxicity of the mice was decreased by over 43% after the 6-day LiCl treatment, but was x 2.5 higher then the control value after a longer 21-d treatment. These results indicate that the immunomodulatory capacity of lithium is dependent on the type of cell population studied, and on the schedule of administration.
authors.affiliation: Department of Immunology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Kubera
authors.forename: M
authors.initials: M
authors.lastname: Bubak-Satora
authors.forename: V
authors.initials: V
authors.lastname: Holan
authors.forename: W
authors.initials: W
authors.lastname: Krol
authors.forename: A
authors.initials: A
authors.lastname: Basta-Kaim
authors.forename: A
authors.initials: A
authors.lastname: Roman
authors.forename: A
authors.initials: A
authors.lastname: Skowron-Cendrzak
authors.forename: J
authors.initials: J
authors.lastname: Shani
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D016827:CD8 Antigens / Q000276:immunology / Q000502:physiology; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006087:Graft vs Host Reaction / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D018021:Lithium Chloride / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008223:Lymphoma; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity; D013154:Spleen / Q000201:enzymology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D016827:CD8 Antigens; D018021:Lithium Chloride