title: [Hepatic toxicity of drugs].
abstract: This review deals in its first part with the hepatic mechanisms of drug detoxification and toxification as well as with the physiopathological mechanisms of drug-induced liver diseases. In the second part, the clinical and biological pictures of drug-induced pathological lesions are reviewed. Any liver abnormality should alert the clinician towards a possible toxic aetiology so that the risk of fulminant, eventually lethal, or of severe chronic liver disease can be avoided.
authors.affiliation: Service médico-chirurgical d'Hépato-Gastro-entérologie, Hôpital Erasme, Bruxelles.
authors.forename: M
authors.initials: M
authors.lastname: Adler
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects*; D008113:Liver Neoplasms / Q000139:chemically induced; D004364:Pharmaceutical Preparations / Q000378:metabolism
chemical_list: D004364:Pharmaceutical Preparations
vernacular_title: Toxicité hépatique des médicaments.