Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A.
Chronic treatment of rats with clorgyline (1 mg/kg i.p. daily for 21 days) caused a highly significant increase in the concentration of noradrenaline in microdialysate from the frontal cortex of the awake animal. Acute (one injection, 2 mg/kg) or subacute (1 mg/kg daily for 3 days) treatment did not lead to a significant increase in microdialysate noradrenaline. Concentrations of deaminated metabolites (DPHG, MHPG, DOPAC) in the microdialysate decreased with time of treatment, reaching a minimum after 21 days.
Finberg
J P
JP
Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Pacak
K
K
Goldstein
D S
DS
Kopin
I J
IJ
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D003010:Clorgyline / Q000008:administration & dosage / Q000494:pharmacology; D017551:Microdialysis; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D009994:Osmolar Concentration; D051381:Rats; D013997:Time Factors
D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D003010:Clorgyline; D009638:Norepinephrine