title: Calcitonin-producing insulinoma: clinical, immunocytochemical and cytogenetical study.
abstract: The case of a patient with a large goitre associated with hypercalcitoninaemia and fasting hypoglycaemia is reported. Pentagastrin (PG) test was negative. Repeated measurements of fasting glycaemia, insulin and C peptide established the diagnosis of insulinoma. After localization by endoscopic ultrasonography, a distal pancreatectomy was performed and a small insulinoma was recovered. Glycaemia and calcitonin (CT) became normal. The tumour cells displayed a strong immunoreactivity for insulin and CT. Cytogenetical evaluation of the tumour revealed a translocation t(1;9) (p13;p22).
authors.affiliation: Department of Endocrinology, Portuguese Cancer Institute, Lisbon, Portugal.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bugalho
authors.forename: L
authors.initials: L
authors.lastname: Roque
authors.forename: L G
authors.initials: LG
authors.lastname: Sobrinho
authors.forename: A
authors.initials: A
authors.lastname: Hoog
authors.forename: J F
authors.initials: JF
authors.lastname: Nunes
authors.forename: J M
authors.initials: JM
authors.lastname: Almeida
authors.forename: C N
authors.initials: CN
authors.lastname: Leitão
authors.forename: J R
authors.initials: JR
authors.lastname: Santos
authors.forename: M C
authors.initials: MC
authors.lastname: Pereira
authors.forename: M A
authors.initials: MA
authors.lastname: Santos
mesh_terms: D000368:Aged; D002116:Calcitonin / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006042:Goiter / Q000209:etiology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007328:Insulin / Q000032:analysis; D007340:Insulinoma / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007621:Karyotyping; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014178:Translocation, Genetic
chemical_list: D007328:Insulin; D002116:Calcitonin