title: [An experimental study on liver hyperthermia using intraperitoneal hyperthermic perfusion (IPHP)].
abstract: We evaluated the efficacy of intraperitoneal hyperthermic perfusion (IPHP) in regional hyperthermia of the liver. In white rabbits, an infusion catheter and a drainage catheter were placed in the Douglas pouch and upper abdominal cavity, respectively. Warm saline (46-48 degrees C) was infused into the abdominal cavity at a flow rate of 30-60 ml/min. The temperature was continuously monitored at seven measuring points including water bath, peritoneal inflow line, abdominal cavity, liver parenchyma, portal vein, rectum and esophagus. Temperature of the inflow line was maintained at 46-48 degrees C throughout the course. Temperature of the abdominal cavity reached 42.0-42.6 degrees C 30 minutes after the start of IPHP. The temperature of the portal vein reached 40.9 degrees C and 41.8 degrees C at 30 and 60 minutes, respectively. Liver parenchymal temperature increased to 41.5 degrees C and 42.1 degrees C at 30 and 60 minutes, respectively, indicating effective heating of the liver. On the other hand, the temperatures of the rectum and esophagus remained less than 39.2 degrees C and 40.4 degrees C throughout the course. Therefore, we consider that IPHP will be a simple and effective method for the performance of liver hyperthermia.
authors.affiliation: First Dept. of Surgery, Kobe University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Kitagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ku
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
mesh_terms: D000818:Animals; D001831:Body Temperature; D002408:Catheters, Indwelling; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D006979:Hyperthermia, Induced / Q000379:methods*; D008099:Liver / Q000502:physiology*; D010537:Peritoneum; D011817:Rabbits