title: The role of metabolic transformations in generation of biological order.
abstract: Transformations of metabolic organization are considered as a ground of structure generation during ontogenesis and evolution. The emergence of non-linearity in metabolic pathways which leads to the formation of biochemical cycles is caused by the separation between the direct and reverse enzymatic reactions, one of them being coupled with the pool of macroergs, whereas the other--non-coupled. The absence of couplings in one of the halves of such primary cycle can lead to the increase of metabolic flow and to the generation of bifurcations resulting in the formation of new metabolic pathway. For their internalization the genetic reconstructions are necessary. Deposition of compounds from the cycles leads to the generation of internal rhythms and to morphogenetic processes. Morphology is formed by stable trajectories of the formation and deposition of certain compounds according to the principles of curvilinear symmetry.
authors.affiliation: Department of Plant Physiology and Biochemistry, Voronezh State University, Russia.
authors.forename: A U
authors.initials: AU
authors.lastname: Igamberdiev
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001695:Biology; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008660:Metabolism; D009024:Morphogenesis; D010507:Periodicity; D015219:Substrate Cycling; D013598:Systems Theory; D013997:Time Factors
chemical_list: D004798:Enzymes; D007527:Isoenzymes