title: Static posturography and intravenous alcohol.
abstract: Twelve health subjects were assessed using static posturography before and after intravenous alcohol infusion in a double-blind experiment. The dose was 0.5 g ethanol per kg body weight in 15 minutes, which raised the blood alcohol concentration to a level of approximately 1 mg/mL. Among other parameters, the average body sway velocity (BSV) and area of body sway (BSA) were measured. BSV was the most sensitive parameter for detecting increased body sway after alcohol infusion, and a significant effect of alcohol on its values was seen at 0.46 to 1.0 mg/mL alcohol concentrations. The second best indicator was the BSA. There was a positive correlation between the BSV and the BSA. The other parameters were not affected. The Romberg quotient remained constant during the alcohol test. The test battery used was relevant to distinguish the effect of alcohol on balance. In this study, acute blood alcohol concentrations of around 0.5 to 1.0 mg/mL affected BSV more significantly than BSA. The authors do not, however, recommend the test for forensic purposes in examining drivers with alcohol in their blood, as there is too much interindividual dispersion in the results.
authors.affiliation: Department of Otolaryngology, University of Oulu, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Uimonen
authors.forename: K
authors.initials: K
authors.lastname: Laitakari
authors.forename: R
authors.initials: R
authors.lastname: Bloigu
authors.forename: M
authors.initials: M
authors.lastname: Reinilä
authors.forename: M
authors.initials: M
authors.lastname: Sorri
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D004311:Double-Blind Method; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009068:Movement / Q000187:drug effects; D009799:Ocular Physiological Phenomena; D004856:Postural Balance / Q000187:drug effects*; D011187:Posture / Q000502:physiology*
chemical_list: D000431:Ethanol