Changes of endothelin concentration in cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage.
To investigate the clinical significance of endothelin (ET), a potent vasoconstrictor peptide, in subarachnoid hemorrhage (SAH) and SAH-related cerebral vasospasm, we measured the ET-like immunoreactivity (ET-LI) in plasma and cerebrospinal fluid (CSF) obtained serially from patients with SAH due to ruptured cerebral aneurysm who underwent aneurysmal surgery. The normal ET-LI levels in plasma and CSF (n = 24) were 12.4 +/- 2.0 (mean +/- s.d.) and 9.1 +/- 1.2 pg.ml-1, respectively. Plasma ET-LI levels in patients with SAH before surgery (16.8 +/- 7.8 pg.ml-1, n = 8) were higher than the normal values (P < 0.05), and became further elevated after surgery (22.5 +/- 9.4 pg.ml-1). ET-LI levels in plasma and CSF one day after surgery were 18.7 +/- 5.5 and 18.4 +/- 6.8 pg.ml-1 (P < 0.01 vs. normal values), respectively, and declined thereafter. The plasma and CSF ET-LI levels in patients who showed symptomatic vasospasm became concomitantly elevated again. These results suggest that ET is involved in SAH-related vasospasm and raise the possibility that surgical stress influences the vasospasm.
Shirakami
G
G
Department of Anesthesia, Kyoto University Hospital, Japan.
Magaribuchi
T
T
Shingu
K
K
Kim
S
S
Saito
Y
Y
Nakao
K
K
Mori
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016232:Endothelins / Q000032:analysis / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000601:surgery; D002546:Ischemic Attack, Transient / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000601:surgery; D013997:Time Factors
D016232:Endothelins