title: The origin of muscle fasciculations and cramps.
abstract: The anatomic site of origin of muscle fasciculations and cramps has been debated for many years. Many authors have argued for a central origin of the abnormal discharges in the anterior horn cells. However, most of the evidence favors a very distal origin in the intramuscular motor nerve terminals. The factors giving rise to these discharges are not well understood. Fasciculations may be related to chemical excitation of motor nerve terminals, whereas cramps may result from mechanical excitation of motor nerve terminals during muscle shortening.
authors.affiliation: Department of Neurology, University of California, San Francisco 94143.
authors.forename: R B
authors.initials: RB
authors.lastname: Layzer
mesh_terms: D005207:Fasciculation / Q000503:physiopathology; D006801:Humans; D009120:Muscle Cramp / Q000503:physiopathology*; D009132:Muscles / Q000294:innervation; D009407:Nerve Block