Alkaloids from Lycopodium casuarinoides.
In addition to huperzinine [1], a new alkaloid, N-demethylhuperzinine [2], was isolated from the aerial parts of Lycopodium casuarinoides by bioassay-directed fractionation. The structure of 2 was established by spectral analysis and extensive nOe difference nmr studies as well as spectral comparison with huperzinine. N-Demethylhuperzinine [2] exhibited anticholinesterase activity in pharmacological studies.
Shen
Y C
YC
Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Chen
C H
CH
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D051379:Mice; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry*
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; C089564:N-demethylhuperzinine; C058370:huperzinine