title: Evaluation of chemopreventive effects of betel leaf on the genotoxicity of pan masala.
abstract: The antigenotoxic effect of the aqueous extract of betel leaf (BL-ext.) against the pan masala was tested with the help of cytogenetic endpoints like chromosome aberration (CA) and sister chromatid exchange (SCE) utilizing Chinese hamster ovary (CHO) cells. Compared to the cultures treated with aqueous extract of pan masala alone, a reduction in CA and SCE frequencies in CHO cells was observed following a combined treatment with pan masala (with or without tobacco) extract and BL-ext. The protective effect of BL-ext. against the genomic damage caused by pan masala was statistically significant only after treating the cells for a longer period.
authors.affiliation: Cell Biology Division, Gujarat Cancer Society, Ahmedabad, India.
authors.forename: A H
authors.initials: AH
authors.lastname: Trivedi
authors.forename: R K
authors.initials: RK
authors.lastname: Patel
authors.forename: U M
authors.initials: UM
authors.lastname: Rawal
authors.forename: S G
authors.initials: SG
authors.lastname: Adhvaryu
authors.forename: D B
authors.initials: DB
authors.lastname: Balar
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001114:Areca / Q000737:chemistry*; D016466:CHO Cells / Q000187:drug effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D004249:DNA Damage; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D010947:Plants, Toxic; D012854:Sister Chromatid Exchange; D014030:Tobacco, Smokeless
chemical_list: D016588:Anticarcinogenic Agents; D010936:Plant Extracts