A Ro/SS-A auto-antibody positive mother's infant revealed congenital complete atrioventricular block, followed by insulin dependent diabetes mellitus and multiple organ failure.
We experienced a congenital complete atrioventricular block infant who was born from a Ro/SS-A antibody positive mother. Ro/SS-A antibody was also found in this baby which was presumed to be mediated by the maternal placenta. Temporary cardiac pacing was required at birth and pacemaker implantation was performed at 9 months. At 11 months of age, the baby fell into shock and experienced multiple organ failure because of diabetes mellitus-induced coma. The association between congenital complete heart block and the Ro/SS-A antibody is well known. However, the accompaniment of insulin-dependent diabetes mellitus has not been reported previously. As the Ro/SS-A antigen appears in the cytoplasm of many tissues, the possibility of an association between Ro/SS-A antibody and diabetes mellitus is difficult to deny. We report this rare case to draw attention to the possibility that babies who are born from an Ro/SS-A antibody positive mother may develop diabetes mellitus as well as congenital complete heart block.
Fukazawa
R
R
Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
Seki
T
T
Kamisago
M
M
Watanabe
M
M
Ogawa
S
S
Yuge
K
K
Hirayama
T
T
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D002135:Calcium-Binding Proteins / Q000276:immunology*; D037282:Calreticulin; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D005260:Female; D006327:Heart Block / Q000151:congenital*; D006801:Humans; D007223:Infant; D009102:Multiple Organ Failure / Q000209:etiology*; D012261:Ribonucleoproteins / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D002135:Calcium-Binding Proteins; D037282:Calreticulin; D012261:Ribonucleoproteins