title: Synthesis of substituted [1]benzothieno[2,3-b]pyrazines and their ability to antagonize KCl induced contractions.
abstract: A series of substituted [1]benzothieno [2,3-b]pyrazines, structurally related to caroverine, was synthesized. Some of these compounds showed an appreciable inhibition towards KCl induced contractions on isolated rat aortic rings, and a lower potency towards negative inotropic activity tested on isolated guinea pig atrium.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Guerrera
authors.forename: L
authors.initials: L
authors.lastname: Salerno
authors.forename: M C
authors.initials: MC
authors.lastname: Sarvà
authors.forename: M A
authors.initials: MA
authors.lastname: Siracusa
authors.forename: A
authors.initials: A
authors.lastname: Rescifina
authors.forename: R
authors.initials: R
authors.lastname: Scalia
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D011189:Potassium Chloride / Q000494:pharmacology; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D002121:Calcium Channel Blockers; D011719:Pyrazines; D011810:Quinoxalines; D011189:Potassium Chloride; C000957:caroverine