The potentiating effect of propionyl carnitine on prostacycline prevention of thrombosis induced by endothelin (ET-1) and K-carrageenin.
The aim of the present experiments was to ascertain whether prostacycline could exercise a protective effect against the formation of thrombosis in the rat tail induced by endothelin and K-carrageenin and to compare the effect of prostacycline with that of carnitine and propionyl carnitine. Both prostacycline and propionyl carnitine exhibited a similar protective effect on this experimental model. A combined protective effect of prostacycline administered with carnitine was also observed and a possible interaction between these two substances is proposed.
Bertelli
A
A
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
Bertelli
A A
AA
Giovannini
L
L
D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002331:Carnitine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002351:Carrageenan; D004357:Drug Synergism; D016232:Endothelins; D011464:Epoprostenol / Q000627:therapeutic use*; D008297:Male; D009336:Necrosis / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013623:Tail / Q000473:pathology; D013927:Thrombosis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D002316:Cardiotonic Agents; D016232:Endothelins; C003223:propionylcarnitine; D002351:Carrageenan; D011464:Epoprostenol; D002331:Carnitine