title: Carriage of antibiotic-resistant Escherichia coli by healthy volunteers during a 15-week period.
abstract: Escherichia coli strains (n = 678 and n = 670) isolated from faecal samples from 90 and 93 healthy volunteers of two cities, Weert and Roermond respectively, were analysed for their susceptibility to 12 antimicrobial agents during a 15-week period. Significant differences between both cities in the distribution of the MIC values were observed for apramycin, chloramphenicol, kanamycin, neomycin, nitrofurantoin, sulfamethoxazole and trimethoprim. For Weert (n = 678) the antibiotic resistance percentages varied from 0.4% for nalidixic acid to 26.7% for sulfamethoxazole. For Roermond (n = 670) the figures varied from 0.6% for nitrofurantoin to 37.5% for sulfamethoxazole. Resistance to amoxicillin/clavulanate was not found in either city. The most frequent pattern was resistance to sulfamethoxazole only, followed by resistance to oxytetracycline, streptomycin and sulfamethoxazole. In each individual there was only a small variation in resistance patterns of the isolates, i.e. the majority had one (n = 51) or two (n = 63) patterns with a maximum of five during the 15-week period. A fully susceptible pattern was found in the strains from 38 individuals.
authors.affiliation: Dept. of Medical Microbiology, University of Limburg, Maastricht, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: London
authors.forename: R
authors.initials: R
authors.lastname: Nijsten
authors.forename: A
authors.initials: A
authors.lastname: van der Bogaard
authors.forename: E
authors.initials: E
authors.lastname: Stobberingh
mesh_terms: D002353:Carrier State / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D004352:Drug Resistance, Microbial; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009426:Netherlands / Q000453:epidemiology; D011159:Population Surveillance; D012424:Rural Population; D014505:Urban Population; D014838:Volunteers