Burkitt lymphoma with a duplication of der(8)t(2;8). Interpretation of a complex karyotype by chromosome painting.
A 51-year-old male patient was diagnosed with Burkitt lymphoma 3 months after cardiac transplantation. The bone marrow karyotype was very complex, and to better define the complex karyotype we used the in situ suppression hybridization technique. Previously we interpreted this karyotype to be: 48,XY,t(2;8)(p11;q24), +der(2)t(2;8)(p11;q24),del(2)(q23), +7, +der(8)t(2;8)(p11;q24), +12, -13, -18, by G banding techniques, with a duplication of the t(2;8) derivatives. After in situ hybridization we changed to a: 48,XY,t(2;8)(p11;q24),t(2;18)(q23;q22), +7, +der(8)t(2;8)(p11;q24), +12, -13, which implies duplication of only one t(2;8) derivative.
Vázquez-Mazariego
Y
Y
Medical Genetics Department, Hospital Ramón y Cajal, Madrid, Spain.
Cabello
P
P
García-Sagredo
J M
JM
López-Yarto
A
A
Vallcorba
I
I
Resino
M
M
Muñoz
R
R
Pérez
I
I
Mayayo
M
M
Ferro
M T
MT
D002051:Burkitt Lymphoma / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2; D002898:Chromosomes, Human, Pair 8; D005821:Genetic Techniques; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D014178:Translocation, Genetic