[Inefficacy of diltiazem in restenosis prevention after coronary angioplasty].
OBJECTIVE
To evaluate the efficacy of diltiazem in preventing restenosis after balloon angioplasty (PTCA).


METHODS
Eighty-nine patients who were undergone to successful PTCA, were divided them in 2 groups (G): A) 44 patients (50%) who received diltiazem (180 mg tid) immediately after PTCA and were kept on it for 6 months); B) 45 patients (50%) who received placebo. Fifty two lesions were dilated in GA and 54 in GB. Patients were excluded from analysis for several reasons, including: necessity of diltiazem or others calcium channel blockers use; heart failure, bradicardia, AV block of any degree, PTCA to chronic total occlusion, ostial lesions and AMI less than 30 days prior to PTCA. Patients were randomized to either the active drug or placebo in a double blind fashion. Restenosis was defined as a 50% lesion. Patients underwent late angiography either at 6 months or sooner if clinically indicated.


RESULTS
Both G were similar to age > 70 years (A = 7% vs B = 4%-p = NS), sex (A = 13% vs B = 11%-p = NS), stable angina (A = 43% vs B = 51%), unstable angina (A = 57% vs B = 49%-p = NS) and single vessel (A = 91% vs B = 87%-p = NS) or multivessel (A = 9% vs B = 13%-p = NS) PTCA. We studied 39/44 (89%) patients in GA and 43/45 (96%) in GB (p = NS). We observed restenosis in 17/39 (43%) in GA and 16/43 (37%) in GB (p = NS). The restenosis rate per lesion was 39% in GA and 31% in GB (p = NS).


CONCLUSIONS
Diltiazem was ineffective in the prevention of restenosis following PTCA.
Tanajura
L F
LF
Instituto Dante Pazzanese de Cardiologia, São Paulo.
Sousa
A G
AG
Feres
F
F
Atallah
T
T
Pinto
I M
IM
Centemero
M P
MP
Chaves
A J
AJ
Mattos
L A
LA
Martins
H C
HC
Abud
R L
RL
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000517:prevention & control* / Q000628:therapy; D004110:Diltiazem / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012008:Recurrence
D004110:Diltiazem
Ineficácia do diltiazem na prevenção da reestenose após angioplastia coronária.