Effect of the butyric short-chain fatty acid on the intracranial pressure and EEG of rabbits.
In the present study we followed the changes in the intracranial pressure and EEG activity of rabbits caused by the butyric short-chain fatty acid infused as an 0.2 M solution at the rate of 12 ml/h. Changes in the rabbit's normal EEG of paroxysmal nature were initially observed, followed by a rise of intracranial pressure as a result of the edema that developed in the brain. Pretreatment of the animals with an inhibitor of the prostaglandin (PG) synthesis (indomethacin, i.v. 10 mg/kg b.w.) prevented the appearance of paroxysms. The intracranial pressure increased in the presence of indomethacin, but there was a tendency towards reduction of the maximal value reached in the control animals. We conclude that the PG system participates to a varying degree in the genesis of the butyrate-induced changes in the bioelectric cerebral activity and intracranial pressure.
Katsarov
V
V
Department of Biophysics, University of Medicine, Plovdiv, Bulgaria.
Kostadinova
I
I
Kristev
A
A
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002087:Butyrates / Q000008:administration & dosage / Q000494:pharmacology*; D020148:Butyric Acid; D004569:Electroencephalography; D007213:Indomethacin / Q000494:pharmacology; D007262:Infusions, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits
D002087:Butyrates; D020148:Butyric Acid; D007213:Indomethacin