title: Kinins as vasoactive peptides.
abstract: During the past year, a number of significant publications have provided data that clearly establish the basis for the important role of the tissue kallikrein-kinin system in cardiovascular control and renal function. These publications include a report of advances in techniques for system component measurement, reports of the localization of central bradykinin receptors and an alteration in the sensitivity of the central bradykinin system in hypertension, and a description of the effects of new kinin receptor antagonists on our understanding of endogenous and exogenous kinin-induced vasorelaxation and its possible alteration in hypertension. Several significant reports describe the potentiation of endogenous kinin action by kininase inhibitors and establish the important interaction between kininase activity and kinin control of blood pressure.
authors.affiliation: Department of Medicine, Medical University of South Carolina, Charleston.
authors.forename: W R
authors.initials: WR
authors.lastname: Fitzgibbon
authors.forename: D W
authors.initials: DW
authors.lastname: Ploth
authors.forename: H S
authors.initials: HS
authors.lastname: Margolius
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D007668:Kidney / Q000502:physiology; D007705:Kinins / Q000378:metabolism / Q000502:physiology*; D008969:Molecular Sequence Data; D010455:Peptides / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology
chemical_list: D007705:Kinins; D010455:Peptides