[Effect of traditional Chinese medicine (dai-saiko-to) on experimental calcinosis].
To clarify the anti-calcinosis actions of traditional Chinese medicine (Dai: Dai-saiko-to) and estradiol benzoate (E2), 7-week or retired (about 6-months-old) female rats were treated with Vit. D2 (1.75 x 10(5) I.U./kg b.w./day) for 4 days, and then were fed a basal diet containing Dai (at ten times the medical dose in humans) or were injected i.p. with E2 (at the medical dose in humans) for 6 weeks. The following results were obtained: 1) Dai did not improve Ca and P metabolism in experimental calcinosis of 7-week female rats; 2) in retired female rats, Dai decreased both P in the heart and the ratio of Ca to P in bone, similar to the treatment with E2. Dai, as well as E2, seemed to nomalize Ca and P metabolism disturbed by Vit. D2 treatment.
Goto
M
M
Department of Clinical Chemistry, Hoshi College of Pharmacy, Tokyo, Japan.
Hayashi
M
M
Seyama
Y
Y
Yamashita
S
S
D000818:Animals; D002114:Calcinosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004872:Ergocalciferols; D004958:Estradiol / Q000627:therapeutic use; D005260:Female; D009206:Myocardium / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D004872:Ergocalciferols; C051121:daisaikoto; D010758:Phosphorus; D004958:Estradiol; D002118:Calcium