title: Endothelial regulation of vascular tone.
abstract: Through the release of a variety of relaxing and contracting factors, including nitric oxide and endothelin-1, the endothelium exerts a complex paracrine influence on vascular smooth muscle cells. Dysfunction of these mechanisms for regulating tone may have relevance to various clinical entities, including hypertension, atherosclerosis, renal failure, and diabetes.
authors.affiliation: University of Colorado School of Medicine, Denver.
authors.forename: J D
authors.initials: JD
authors.lastname: Conger
mesh_terms: D001161:Arteriosclerosis / Q000503:physiopathology; D003251:Constriction, Pathologic / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology; D004108:Dilatation, Pathologic / Q000503:physiopathology; D016232:Endothelins / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology; D051437:Renal Insufficiency / Q000503:physiopathology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: D016232:Endothelins; D009569:Nitric Oxide