title: Non-shivering thermogenesis during prostaglandin E1 fever in rats: role of the cerebral cortex.
abstract: We have tested the hypothesis that there is a role for the cerebral cortex in the control of non-shivering thermogenesis during fever induced by prostaglandin E1 (PGE1). While under urethan anesthesia, the firing rate of nerves innervating interscapular brown adipose tissue (IBAT), IBAT and colonic temperatures (TIBAT and Tc) and oxygen (O2) consumption were monitored during the fever from PGE1 injection (400 and 800 ng) in a lateral cerebral ventricle in controls and in functionally decorticated Sprague-Dawley rats. Rats were functionally decorticated by applying 3.3 M KCl solution on the frontal cortex which causes cortical spreading depression (CSD). Pyrogen injections caused dose-related increases in firing rate, TIBAT, Tc and O2 consumption and CSD reduced these enhancements. Our findings indicate that the cerebral cortex could be involved in the control of non-shivering thermogenesis during PGE1-induced febrile response.
authors.affiliation: Department of Human Physiology, Faculty of Medicine and Surgery, Second University of Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Monda
authors.forename: S
authors.initials: S
authors.lastname: Amaro
authors.forename: B
authors.initials: B
authors.lastname: De Luca
mesh_terms: D002001:Adipose Tissue, Brown / Q000294:innervation / Q000503:physiopathology*; D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D002540:Cerebral Cortex / Q000503:physiopathology*; D013181:Cortical Spreading Depression; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D010101:Oxygen Consumption; D051381:Rats; D017207:Rats, Sprague-Dawley; D012768:Shivering; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D000527:Alprostadil