title: Coexisting sharp ductal angulation with intrahepatic biliary strictures in right hepatolithiasis.
abstract: OBJECTIVE
  To investigate the clinical characteristics of a coexisting sharp ductal angulation (< 90 degrees) with biliary stricture and to evaluate the difficulties it imposes in the management of retained or recurrent hepatolithiasis.
  
  
  METHODS
  Case-controlled study.
  
  
  METHODS
  A referral center.
  
  
  METHODS
  Eighteen consecutive patients having right-sided hepatolithiasis and a coexisting sharp ductal angulation associated with biliary stricture (group 1) were compared with 84 patients matched with sex, age, and conditions of hepatolithiasis and intrahepatic biliary stricture(s) but no sharp angulated duct (group 2).
  
  
  METHODS
  Postoperative cholangioscopic management (electrohydraulic lithotripsy or other lithotripsy, lithotomy, balloon dilation, biopsy, etc, via T-tube tract or percutaneous transhepatic route).
  
  
  METHODS
  Sessions of manipulations, incidence of complications associated with interventions or disease, and mortality were compared.
  
  
  RESULTS
  Patients of group 1 needed more sessions of postoperative manipulation of stones and strictures (13.7 +/- 4.2 vs 8.0 +/- 2.3; P < .001). During management, there was a significantly increased vulnerability of severe and/or recurrent cholangitis (66.7% vs 9.5%; P < .001), septic shock (77.8% vs 11.9%; P < .001), liver abscess (55.6% vs 7.1%; P < .001), or massive hemobilia (33.3% vs 7.4%) in group 1 than in group 2. Their risks of coexisting secondary biliary cirrhosis (55.6% vs 9.5%; P < .001) and/or cholangiocarcinoma (16.6% vs 2.4%; P < .04) and mortality (27.8% vs 4.8%; P < .01) were also significantly higher in group 1.
  
  
  CONCLUSIONS
  Our results suggest that the coexisting sharp ductal angulation with biliary strictures in right-sided hepatolithiasis is a distinct difficult clinical entity in the field of biliary tract calculi.
authors.affiliation: Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China.
authors.forename: K S
authors.initials: KS
authors.lastname: Jeng
authors.forename: I
authors.initials: I
authors.lastname: Ohta
authors.forename: F S
authors.initials: FS
authors.lastname: Yang
authors.forename: T P
authors.initials: TP
authors.lastname: Liu
authors.forename: S C
authors.initials: SC
authors.lastname: Shih
authors.forename: W S
authors.initials: WS
authors.lastname: Chang
authors.forename: H Y
authors.initials: HY
authors.lastname: Wan
authors.forename: S H
authors.initials: SH
authors.lastname: Huang
mesh_terms: D000328:Adult; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D002137:Calculi / Q000150:complications*; D016022:Case-Control Studies; D003251:Constriction, Pathologic / Q000150:complications; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged