NSAID--induced gastroduodenal ulcers: exploring the silent dilemma.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective medications and are very commonly prescribed. They are used by a large proportion of elderly persons who are most prone to adverse events. NSAID gastropathy is the commonest side effect. The relative risk of adverse events is high, but the absolute risk for any individual patient is low. Individualizing the risk/benefit ratio would lead to cost effective care.
Mohamed
A H
AH
McMaster University Medical Centre, Hamilton, Ontario, Canada.
Salena
B J
BJ
Hunt
R H
RH
D000367:Age Factors; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005767:Gastrointestinal Diseases / Q000150:complications; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use; D011453:Prostaglandins / Q000096:biosynthesis; D012307:Risk Factors; D012737:Sex Factors; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006635:Histamine H2 Antagonists; D011453:Prostaglandins; D016595:Misoprostol