title: Is there a relationship between indomethacin-induced reduction in neonatal cerebral blood flow velocity and prostaglandin production?
abstract: Indomethacin lowers neonatal cerebral perfusion immediately after intravenous administration. It is important to elucidate whether this reduction is mediated by inhibition of production of prostaglandins, especially prostacyclin, which plays an important role in the autoregulation of the neonatal cerebral vascular bed. We studied changes in cerebral blood flow by serial measurements of temporal mean flow velocity in the anterior cerebral artery (TMFV-ACA), relative cerebral vascular resistance (R-cer), and prostaglandins (measured as changes in thiobarbituric acid reactive substances concentration; TBARS) after a therapeutic dose of 0.1 mg/kg indomethacin administered intravenously for noninvasive closure of patent ductus arteriosus. TMFV-ACA decreased and R-cer increased immediately after the indomethacin administration with a sustained recovery to pre-indomethacin values. The TBARS concentrations, however, did not change during the study period. We conclude that the present study suggests that a therapeutic dose of 0.1 mg/kg of indomethacin has no impact on prostaglandin metabolism.
authors.affiliation: Department of Pediatrics, Neonatal Unit, University Hospital of Leiden, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: van Bel
authors.forename: D
authors.initials: D
authors.lastname: van Zoeren
authors.forename: E
authors.initials: E
authors.lastname: Houdkamp
authors.forename: H M
authors.initials: HM
authors.lastname: Berger
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D016014:Linear Models; D011453:Prostaglandins / Q000096:biosynthesis*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D011453:Prostaglandins; D017392:Thiobarbituric Acid Reactive Substances; D007213:Indomethacin