title: [Clinical study on the effect of intra-arterial injection of mitoxantrone-lipiodol emulsion for hepatocellular carcinoma].
abstract: To investigate the effect of intra-arterial injection of mitoxantrone emulsified with ethiodized oil, forty-eight patients with hepatocellular carcinoma were evaluated. After the treatment, ten of the patients underwent hepatectomy. In the thirty-eight unresected cases, there were 15 (39%) partial responses, which continued 1.2 to 11.8 months (mean, 5.8 months). The 1- and 2- year survival rates were 67% and 38%, respectively. The response rate was higher in cases with tumor under 5 cm in diameter. In the remaining 10 resected cases, the necrotic areas in main nodules ranged from 65% to 100% (mean, 85%). This treatment might be applied effectively to patients with small hepatocellular carcinoma.
authors.affiliation: Dept. of Surgery, Tojun Hospital.
authors.forename: W
authors.initials: W
authors.lastname: Ichikawa
authors.forename: S
authors.initials: S
authors.lastname: Togo
authors.forename: T
authors.initials: T
authors.lastname: Osanai
authors.forename: T
authors.initials: T
authors.lastname: Miyanaga
authors.forename: S
authors.initials: S
authors.lastname: Sawai
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Kawachi
authors.forename: Z
authors.initials: Z
authors.lastname: Nihei
authors.forename: R
authors.initials: R
authors.lastname: Hirayama
authors.forename: Y
authors.initials: Y
authors.lastname: Mishima
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage*
chemical_list: D007459:Iodized Oil; D008942:Mitoxantrone