Inhibition of the growth of cariogenic bacteria in vitro by plant flavanones.
Phytoalexins, defensive compounds produced by plants against microbial infections, were purified from Sophora exigua (Leguminosae) and their growth inhibitory effects on oral cariogenic bacteria were determined in vitro. Among three isolated compounds, 5,7,2',4'-tetrahydroxy-8-lavandulylflavanone completely inhibited the growth of oral bacteria including primary cariogenic mutans streptococci, other oral streptococci, actinomycetes, and lactobacilli, at concentrations of 1.56 to 6.25 micrograms/ml.
Tsuchiya
H
H
Department of Dental Pharmacology, Asahi University School of Dentistry, Gifu, Japan.
Sato
M
M
Iinuma
M
M
Yokoyama
J
J
Ohyama
M
M
Tanaka
T
T
Takase
I
I
Namikawa
I
I
D000190:Actinomyces / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D003731:Dental Caries / Q000382:microbiology*; D007887:Fabaceae; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D007778:Lactobacillus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010944:Plants / Q000737:chemistry*; D010946:Plants, Medicinal; D013291:Streptococcus / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects
D044950:Flavanones; D005419:Flavonoids; C064849:vexibinol