Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.
Staurosporine aglycone (K252-c) (compound 1) and arcyriaflavin A (2) were isolated from a specimen of the marine ascidian, Eudistoma sp., collected off the coast of West Africa. In addition to expressing micromolar and submicromolar inhibition of enzyme activity against seven protein kinase C isoenzymes and inhibition of proliferation of the human lung cancer A549 and P388 murine leukemia cell lines, 1 also inhibited cell adhesion of the EL-4.IL-2 cell line and expressed activity in the K562 bleb and neutrophil assays.
Horton
P A
PA
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, Florida 34946.
Longley
R E
RE
McConnell
O J
OJ
Ballas
L M
LM
D000354:Africa, Western; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000302:isolation & purification* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D026121:Indole Alkaloids; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007941:Leukemia P388 / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D051379:Mice; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured; D014561:Urochordata
D000970:Antineoplastic Agents; D002227:Carbazoles; D026121:Indole Alkaloids; D007527:Isoenzymes; C089657:arcyriaflavin A; C049985:staurosporine aglycone; D011493:Protein Kinase C