The activity of PS-15 in combination with sulfamethoxazole.
PS-15 is a novel biguanide folate antagonist that is metabolized in vivo to WR99210, a metabolite that is extremely active in vitro against multi-drug resistant strains of Plasmodium falciparum. When PS-15 was administered in combination with sulfamethoxazole to healthy Saimiri sciureus monkeys, the serum antimalarial activity was considerably greater than that observed in monkeys that received PS-15 alone. Further studies should be carried out to determine the value of PS-15/sulfonamide combinations in the treatment of human malaria infections and in preventing the emergence of drug-resistant parasites.
Yeo
A E
AE
Australian Army Malaria Research Unit, University of Sydney.
Rieckmann
K H
KH
D000818:Animals; D000962:Antimalarials / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D001681:Biological Assay; D004338:Drug Combinations; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D005493:Folic Acid Antagonists / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects; D002727:Proguanil / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D012453:Saimiri; D013420:Sulfamethoxazole / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*
D000962:Antimalarials; D004338:Drug Combinations; D005493:Folic Acid Antagonists; C082651:PS 15; D013420:Sulfamethoxazole; D002727:Proguanil