Evaluation of toxicity of cypenhymustine, a new anticancer compound, in mice.
The toxicity of cypenhymustine, a potential anticancer compound 1 (Cancer Letters, 70 (1993) 1-6), was assessed in normal as well as in Ehrlich ascites carcinoma (EAC), Sarcoma-180 (S-180) and Dalton's lymphoma (DL)-bearing Swiss male mice by measuring drug-induced changes in (1) hematological parameters and (2) femoral bone marrow cellularity on day 9 following drug treatment at the optimum dose of 3.0 mg/kg body weight from days 1 to 7. Detailed studies were also made by noting sequential changes in the above parameters in normal and EAC-bearing mice on days 12, 15, 18 and 21, respectively. The results indicate that the compound did not adversely affect hematopoiesis. From the sequential studies, it was observed that after a mild initial decrease in hematological counts, particularly in EAC-bearing treated mice, normalcy was reached within 11-14 days after termination of drug therapy. Drug induced hepatotoxicity and nephrotoxicity were also sequentially evaluated in normal and EAC-bearing mice on days 9, 12 and 15 but no such toxicities were detected. Also, body weight, skin and hair texture, and behavioural pattern (food and water intake and activity) did not reflect any toxic reaction in the host mice at this optimum dose.
Sadhu
U
U
Department of Chemotherapy, Chittaranjan National Cancer Institute, Calcutta, India.
Ghosh
M
M
Bhattacharya
S
S
Dutta
S
S
Das
H
H
Sanyal
U
U
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D056486:Chemical and Drug Induced Liver Injury; D004353:Drug Evaluation, Preclinical; D004906:Erythrocyte Count / Q000187:drug effects; D005269:Femur; D006454:Hemoglobins / Q000378:metabolism; D006827:Hydantoins / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced / Q000201:enzymology; D007958:Leukocyte Count / Q000187:drug effects; D008107:Liver Diseases / Q000201:enzymology; D008297:Male; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000633:toxicity*; D010976:Platelet Count / Q000187:drug effects; D013922:Thrombocytosis / Q000139:chemically induced
D000970:Antineoplastic Agents; D006454:Hemoglobins; D006827:Hydantoins; D009588:Nitrogen Mustard Compounds; C082180:cypenhymustine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase