Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
The cytostatic potency of PMEA was evaluated on five rat and mouse experimental tumors. The compound significantly inhibits three spontaneously arisen (LW13K2, A870N and LLC) tumors. Two chemically induced tumors (FBN, HEP-LEW) were not influenced by PMEA.
Otová
B
B
Department of Biology, First Faculty of Medicine, Charles University, Praha.
Krenová
D
D
Zídek
Z
Z
Holý
A
A
Votruba
I
I
Kren
V
V
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D063065:Organophosphonates; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D014407:Tumor Cells, Cultured
D000998:Antiviral Agents; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine