Synthesis and biological evaluation of derivatives of N-[4-substituted-1-piperazinylalkyl]-1-(butyl,aryl)-2,5- dimethylpyrrole-3,4-dicarboxymide (Part II).
A series of new N-[4-substituted-1-piperazinyl-alkyl]-3,4-pyrroledicarboxyimides 7 have been prepared by reaction of N-haloalkylimide derivatives 6 with corresponding N-monosubstituted piperazines. Compounds 7 tested in preliminary pharmacological investigation produced a general depressive action on the central nervous system.
Malinka
W
W
Department of Drugs Chemistry, Medical Academy, Wroclaw, Poland.
Sieklucka-Dziuba
M
M
Robak
J
J
Kleinrok
Z
Z
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D002492:Central Nervous System Depressants; D010879:Piperazines; D011758:Pyrroles