title: Maternal cocaine use without evidence of fetal exposure.
abstract: We report a case of lack of fetal exposure to cocaine and benzoylecgonine as evidenced by meconium and hair analysis, but exposure to nicotine and its metabolite cotinine, after extensive maternal use of cocaine and nicotine. These data suggest that the mode of maternal use of cocaine and individual differences in placental handling of the drug may protect some fetuses, and highlight the need to address interpatient variability.
authors.affiliation: Department of Psychology and Research Institute, McGill University, Montreal, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Potter
authors.forename: J
authors.initials: J
authors.lastname: Klein
authors.forename: G
authors.initials: G
authors.lastname: Valiante
authors.forename: D M
authors.initials: DM
authors.lastname: Stack
authors.forename: A
authors.initials: A
authors.lastname: Papageorgiou
authors.forename: W
authors.initials: W
authors.lastname: Stott
authors.forename: D
authors.initials: D
authors.lastname: Lewis
authors.forename: G
authors.initials: G
authors.lastname: Koren
authors.forename: P R
authors.initials: PR
authors.lastname: Zelazo
mesh_terms: D000328:Adult; D003042:Cocaine / Q000031:analogs & derivatives / Q000032:analysis* / Q000378:metabolism; D003367:Cotinine / Q000032:analysis; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium / Q000737:chemistry; D009035:Mothers; D009294:Narcotics / Q000032:analysis; D009538:Nicotine / Q000032:analysis; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012907:Smoking; D015819:Substance Abuse, Intravenous
chemical_list: D009294:Narcotics; C005618:benzoylecgonine; D009538:Nicotine; D003042:Cocaine; D003367:Cotinine