In vitro susceptibility of clinical isolates of Mycobacterium avium and M. intracellulare to folate antagonists.
An agar dilution method against trimethoprim, sulfamethoxazole, sulfisoxazole, and trimethoprim-sulfamethoxazole was used to test clinical isolates of Mycobacterium intracellulare (MI) and M. avium (MA) from both HIV-infected and non-infected patients. MI and MA isolates demonstrated similar susceptibility data and were inhibited by concentrations of sulfamethoxazole achievable in serum.
Raszka
W V
WV
Department of Pediatrics, Walter Reed Army Medical Center, Washington, DC.
Skillman
L P
LP
McEvoy
P L
PL
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015269:Mycobacterium avium Complex / Q000187:drug effects* / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000382:microbiology; D013420:Sulfamethoxazole / Q000494:pharmacology; D013424:Sulfanilamides / Q000494:pharmacology*; D013444:Sulfisoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
D005493:Folic Acid Antagonists; D013424:Sulfanilamides; D013444:Sulfisoxazole; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole