title: An epidermal proliferative reaction associated with a silicone gel breast implant.
abstract: A variety of local and systemic adverse reactions has been attributed to silicone prostheses used for augmentation or reconstructive mammoplasty. We present a patient who developed an unusual local cutaneous reaction to a silicone breast implant, which was characterized clinically by macular erythema and focal ulceration and histologically by a basaloid proliferative epidermal reaction. The epidermal changes seen histologically simulated those overlying dermatofibromas and were felt to be reactive secondary to silicone leakage and fibrosis. The process resolved postexplantation of the prosthesis.
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia.
authors.forename: E M
authors.initials: EM
authors.lastname: Spiers
authors.forename: J C
authors.initials: JC
authors.lastname: Grotting
authors.forename: E F
authors.initials: EF
authors.lastname: Omura
mesh_terms: D001941:Breast Diseases / Q000209:etiology / Q000473:pathology; D018427:Breast Implants / Q000009:adverse effects*; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology*; D015745:Granuloma, Foreign-Body / Q000209:etiology / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D012828:Silicones / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology*
chemical_list: D012828:Silicones