What is the dose-response curve for the effects of cyclosporine on calcineurin and cytokine induction in vivo?
Batiuk
T D
TD
Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada.
Yatscoff
R W
RW
Halloran
P F
PF
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis; D015398:Signal Transduction / Q000187:drug effects; D013154:Spleen / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D002148:Calmodulin-Binding Proteins; D016207:Cytokines; D007376:Interleukin-2; D012333:RNA, Messenger; D000001:Calcimycin; D007371:Interferon-gamma; D016572:Cyclosporine; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D013755:Tetradecanoylphorbol Acetate