Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. I. Taxonomy of the producing organism, fermentation and biological activity.
The dorrigocins are new secondary metabolites produced by submerged fermentation of a streptomycete which was isolated from a soil sample collected in Australia. The dorrigocins show moderate antifungal activity and reverse the morphology of ras-transformed NIH/3T3 cells from a transformed phenotype to a normal one. The producing culture was identified as Streptomyces platensis subsp. rosaceus strain AB1981F-75.
Karwowski
J P
JP
Abbott Laboratories, Abbott Park, Illinois 60064.
Jackson
M
M
Sunga
G
G
Sheldon
P
P
Poddig
J B
JB
Kohl
W L
WL
Kadam
S
S
D016475:3T3 Cells / Q000166:cytology* / Q000187:drug effects*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000235:genetics*; D005285:Fermentation; D011905:Genes, ras; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010881:Piperidones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D010881:Piperidones; C089606:dorrigocin A; C089607:dorrigocin B