title: [The prevention of peritoneal dissemination of gastric cancer with intraperitoneal activated carbon particles absorbing mitomycin C].
abstract: A new drug dosage form comprising activated carbon particles absorbing mitomycin C (MMC-CH) has the advantage of being retained in the peritoneal cavity and distributes a larger amount of mitomycin C for a long time. Some 113 patients with gastric cancer and serosal infiltration were randomly assigned intraperitoneal treatment with MMC-CH and no anti-cancer drugs. There were significant differences in survival rate between the patients who have no visible peritoneal dissemination with MMC-CH and without. Thus, intraoperative intraperitoneal treatment with MMC-CH improves survival after gastrectomy for gastric cancer and seems effective against peritoneal recurrence.
authors.affiliation: First Dept. of Surgery, Kyoto Prefectural University of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Ohgaki
authors.forename: T
authors.initials: T
authors.lastname: Imanishi
authors.forename: T
authors.initials: T
authors.lastname: Ohyama
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: K
authors.initials: K
authors.lastname: Ozaki
authors.forename: S
authors.initials: S
authors.lastname: Chohei
authors.forename: M
authors.initials: M
authors.lastname: Shimotsuma
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000042:Absorption; D002244:Carbon; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000517:prevention & control* / Q000556:secondary; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
chemical_list: D016685:Mitomycin; D002244:Carbon