Absorption of ipsapirone along the human gastrointestinal tract.
Isapirone-HCl (5 mg) was administered orally, rectally and locally, by a remote control drug delivery device (HF-capsule) into different segments of the gastrointestinal tract, to four young healthy male adults. The relative systemic bioavailability of the drug from the colon and rectum was 2-3-fold greater than that from the upper gastrointestinal tract. This supports a rationale for a prolonged-release formulation.
Fuhr
U
U
Department of Clinical Pharmacology, University Hospital Frankfurt am Main, Germany.
Staib
A H
AH
Harder
S
S
Becker
K
K
Liermann
D
D
Schöllnhammer
G
G
Roed
I S
IS
D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D002214:Capsules; D003692:Delayed-Action Preparations; D004064:Digestive System / Q000378:metabolism; D016503:Drug Delivery Systems; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D014151:Anti-Anxiety Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D011743:Pyrimidines; C043077:ipsapirone