title: Permissive underfeeding.
abstract: Dietary manipulation may influence outcome after infection and injury by altering production of inflammatory mediators and disease activity. Restricted nutrient intake may have beneficial effects on life-span, development of degenerative disease, autoimmune processes, renal injury, susceptibility to infection, and survival rate after infection. Nutritional therapies that serve to maximize nitrogen balance may adversely affect the host response to injury, especially when given in excess of energy and protein needs. The optimal calorie/protein intake during different phases of critical illness remains to be established. However, a short period of restricted intake may be beneficial.
authors.affiliation: Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1009.
authors.forename: G P
authors.initials: GP
authors.lastname: Zaloga
authors.forename: P
authors.initials: P
authors.lastname: Roberts
mesh_terms: D000818:Animals; D016638:Critical Illness / Q000401:mortality / Q000628:therapy*; D004038:Diet, Reducing / Q000379:methods*; D004195:Disease Models, Animal; D002149:Energy Intake; D004750:Enteral Nutrition / Q000009:adverse effects / Q000379:methods*; D005069:Evaluation Studies as Topic; D006801:Humans; D008136:Longevity; D009751:Nutritional Requirements; D010289:Parenteral Nutrition, Total / Q000009:adverse effects / Q000379:methods*; D015996:Survival Rate