Co-expression of CD2 or CD8 antigens in B-cell chronic lymphocytic leukaemia. A flow cytometry analysis of 3 cases.
Three cases of biphenotypic CD2 or CD8 positive chronic lymphocytic B-cell leukaemias are reported. This represents an incidence of 15% in the authors' series, a frequency never mentioned previously. CD2 expression could be an example of asynchronous expression of an early pre-B antigen. CD8 expression might probe a true mixed lineage phenotype. These aberrant phenotypes were not associated with any peculiar clinical presentation.
Brohée
D
D
Service de Médecine Interne, C.H.U. André Vésale, Université Libre de Bruxelles.
Cauchie
P
P
Nève
P
P
D000368:Aged; D018801:CD2 Antigens / Q000235:genetics*; D016827:CD8 Antigens / Q000235:genetics*; D005434:Flow Cytometry; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D018801:CD2 Antigens; D016827:CD8 Antigens