[The effect of recombinant human erythropoietin during hemodialysis on the thrombocyte and erythrocyte functions of patients with chronic kidney failure].
To elucidate causes of thrombotic complications early in the course of RHE treatment, the authors studied platelet function (by aggregation of washed platelets), cAMP and cGMP as well as TxB2 levels in blood plasma, red cell function (by MDA content) in 16 patients suffering from chronic renal failure (CRF) on hemodialysis. 8 of them had been on RHE for 1.5 months. It appeared that plasma levels of TxB2 and cGMP increased, thrombin-induced platelet aggregation slightly decreased, MDA in red cells on treatment month 1.5 rose. The authors made the conclusion that early in the course of RHE treatment the conditions promoting active thrombogenesis may arise as a result of red cell induced platelet activation due to increased number of red cells with poor resistance to oxidant damage and hemolysis. Application of RHE in CRF patients should be combined with antioxidant therapy, especially in patients at high thrombogenesis risk.
Rud'ko
I A
IA
Balashova
T S
TS
Kubatiev
A A
AA
Ermolenko
V M
VM
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D003131:Combined Modality Therapy; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D004921:Erythropoietin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D006435:Renal Dialysis / Q000706:statistics & numerical data; D018709:Statistics, Nonparametric; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D013997:Time Factors
D011994:Recombinant Proteins; D004921:Erythropoietin
Vliianie rekombinantnogo chelovecheskogo éritropoétina v usloviiakh gemodializa na funktsiiu trombotsitov i éritrotsitov bol'nykh s khronicheskoĭ pochechnoĭ nedostatochnost'iu.