Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. III. Structural elucidation.
The chemical structure of a novel thiopeptide antibiotic, glycothiohexide alpha (1), isolated from the fermentation broth of a "Sebekia" species was determined based on extensive 2D NMR studies, as well as, IR, UV, and mass spectral data. The chemical structure of glycothiohexide alpha is closely related to nosiheptide (3) and antibiotic S-54832A.
Northcote
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Natural Products Research Section, American Cyanamid Company, Pearl River, New York 10965.
Siegel
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Borders
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Lee
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D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004577:Electron Probe Microanalysis; D005971:Glutamates / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry; D015394:Molecular Structure; D010455:Peptides; D013055:Spectrophotometry, Infrared / Q000379:methods; D013057:Spectrum Analysis / Q000379:methods; D013912:Threonine / Q000031:analogs & derivatives / Q000737:chemistry
D000900:Anti-Bacterial Agents; D005971:Glutamates; D006027:Glycosides; D007211:Indoles; D010455:Peptides; C089609:glycothiohexide alpha; D013912:Threonine