title: Is antibiotic treatment of chronic sinusitis effective in children?
abstract: A double-blind randomized controlled trial on 79 patients aged between 2 and 12 years with chronic sinusitis showed no significant advantage of adding antibiotics to the treatment by sinus lavage. The prognosis after both 6 and 12 weeks was worse for patients with bilateral opaque sinus radiographs. Half of the Branhanmella catarrhalis cultured in this study were beta-lactamase producing organisms, therefore antibiotics prescribed for this group of children should be chosen bearing this in mind.
authors.affiliation: Department of Ear, Nose and Throat Medicine, Academic Hospital, Utrecht, The Netherlands.
authors.forename: H W
authors.initials: HW
authors.lastname: Otten
authors.forename: J B
authors.initials: JB
authors.lastname: Antvelink
authors.forename: H
authors.initials: H
authors.lastname: Ruyter de Wildt
authors.forename: S J
authors.initials: SJ
authors.lastname: Rietema
authors.forename: R J
authors.initials: RJ
authors.lastname: Siemelink
authors.forename: G J
authors.initials: GJ
authors.lastname: Hordijk
mesh_terms: D002433:Cefaclor / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003352:Corynebacterium / Q000302:isolation & purification; D004311:Double-Blind Method; D004322:Drainage; D005260:Female; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy; D001936:Moraxella catarrhalis / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D002433:Cefaclor