The ex vivo effects of procarbazine and methylhydrazine on some rat amine oxidase activities.
Monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) activities were examined in homogenates of various rat tissues following i.p. administration of procarbazine or methylhydrazine. Both compounds inhibited SSAO in a dose-dependent manner in all tissues examined, with methylhydrazine the more potent agent in this respect. Little inhibition of MAO could be detected in most cases. However, hepatic MAO-B activity was potentiated significantly in rats receiving methylhydrazine and both drugs caused a dose-dependent potentiation of MAO-A in homogenates of brown adipose tissue. The potential use of these compounds in vivo as selective SSAO inhibitors is discussed.
Holt
A
A
Department of Pharmacology, University of Cambridge, United Kingdom.
Callingham
B A
BA
D002001:Adipose Tissue, Brown / Q000201:enzymology; D006631:Amine Oxidase (Copper-Containing); D000818:Animals; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000201:enzymology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009002:Monomethylhydrazine / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors*; D011344:Procarbazine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008996:Monoamine Oxidase Inhibitors; D011344:Procarbazine; D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase; D000587:Oxidoreductases Acting on CH-NH Group Donors; D009002:Monomethylhydrazine