title: Efficacy of adjunctive thrombolytic therapy in percutaneous transluminal coronary angioplasty.
abstract: Adjunctive thrombolysis has not been shown to improve angioplasty success or complication rates in elective angioplasty or myocardial infarction and may be detrimental in unstable angina. Thrombolysis of chronically occluded vessels achieves recanalization at a rate comparable to conventional angioplasty and is associated with a high rate of complications and limited long-term patency. Thrombolysis administered for thrombus or acute occlusion complicating angioplasty usually achieves coronary artery patency but is unable to forestall complications in many cases. A benefit of thrombolysis in reducing restenosis has not been conclusively demonstrated.
authors.affiliation: Cardiology Unit, Medical Center Hospital of Vermont, University of Vermont, Burlington 05401.
authors.forename: P T
authors.initials: PT
authors.lastname: Vaitkus
authors.forename: W K
authors.initials: WK
authors.lastname: Laskey
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000628:therapy*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D015912:Thrombolytic Therapy; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents