title: Use of a single intrauterine insemination of defrosted cryopreserved sperm for therapeutic donor insemination.
abstract: OBJECTIVE
  To evaluate the efficacy of a protocol employing defrosted cryopreserved sperm as a single well-timed intrauterine insemination.
  
  
  METHODS
  A retrospective observational study.
  
  
  METHODS
  A university fertility service and a private fertility practice located in small metropolitan areas.
  
  
  METHODS
  All 138 donor sperm recipients (348 cycles) treated on this protocol by the author during a 27 month period were evaluated. All 86 patients (200 cycles) treated using intracervical inseminations bracketing the time of ovulation during the same time period were also evaluated.
  
  
  RESULTS
  A single well-timed intrauterine insemination had an associated pregnancy rate of 13.8% per cycle. In contrast, intracervical inseminations bracketing the time of ovulation had an associated pregnancy rate of 5% per cycle (P < .005).
  
  
  CONCLUSIONS
  A single well-timed intrauterine insemination of defrosted cryopreserved sperm is more efficacious and less expensive than intracervical inseminations bracketing the time of ovulation.
authors.affiliation: Fertility and Reproductive Health Services, Lehigh Valley Hospital, Allentown, Pennsylvania.
authors.forename: B I
authors.initials: BI
authors.lastname: Rose
mesh_terms: D015925:Cryopreservation; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D010060:Ovulation; D011247:Pregnancy; D012189:Retrospective Studies; D012661:Semen; D012662:Semen Preservation / Q000379:methods; D013997:Time Factors