Cervical ripening and uterine contraction induced by prostaglandin E2-gel in pregnant Japanese monkeys (Macaca fuscata fuscata).
Effects of intracervical administration of PGE2-gel were studied in pregnant Japanese monkeys (Macaca fuscata fuscata) near term. Administration of PGE2-gel induced cervical ripening and an increase in maternal plasma PGE2 but no change in PGF2 alpha. Ultrastructural observations of the connective tissue of the cervix after PGE2-gel treatment revealed a decrease in the number of collagenous fibers. These results show that intracervical administration of PGE2-gel induces cervical ripening without induction of labor in the Japanese monkey.
Shimizu
K
K
Department of Cellular & Molecular Biology, Kyoto University, Aichi, Japan.
Nozaki
M
M
Oshima
K
K
D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects* / Q000648:ultrastructure; D003094:Collagen / Q000648:ultrastructure; D015237:Dinoprost / Q000097:blood; D015232:Dinoprostone / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects; D008251:Macaca / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects / Q000502:physiology
D003094:Collagen; D015237:Dinoprost; D015232:Dinoprostone