Monoclonal immunoglobulin deposition disease: a review of immunoglobulin chain alterations.
Monoclonal immunoglobulin deposition disease, a complication of overtly malignant or apparently benign immunoproliferative disorders, is a severe disease featuring tissue deposition of monoclonal light, light and heavy, or heavy chains. A number of converging arguments strongly suggest a direct pathogenetic role of structural abnormalities or peculiarities of variables regions of light and/or heavy chains (associated with deletions in the constant region for the heavy chains). Recent structural data on these abnormal immunoglobulin chains are reviewed.
Preud'homme
J L
JL
Laboratory of Immunology and Immunopathology (CNRS URA 1172, Immunology and Molecular Interactions), Poitiers, France.
Aucouturier
P
P
Touchard
G
G
Khamlichi
A A
AA
Rocca
A
A
Denoroy
L
L
Cogné
M
M
D000686:Amyloidosis / Q000276:immunology; D006362:Heavy Chain Disease / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry*; D007147:Immunoglobulin Light Chains / Q000737:chemistry*
D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains