title: Some pharmacological effects of an ethanolic extract of Trema guineensis on the central nervous system in rodents.
abstract: The present study investigates some neuropharmacological effects of an ethanolic extract of the leaves of Trema guineensis (Ulmaceae), a medicinal plant of central Africa. Intraperitoneal administration of the extract induced hypothermia. In addition, the extract significantly shortened the latency to sleep and prolonged the duration of sleeping time induced by sodium pentobarbital in mice. Moreover, T. guineensis significantly delayed the onset of clonic seizures induced by pentylenetetrazole in mice. In contrast, T. guineensis did not affect convulsions induced by maximal electroshock and picrotoxin in mice nor status epilepticus produced by pilocarpine and kainic acid in rats.
authors.affiliation: Laboratoire de Médecine Expérimentale, INSERM U249-CNRS UPR9008, Institut de Biologie, Montpellier, France.
authors.forename: P
authors.initials: P
authors.lastname: N'Gouemo
authors.forename: H
authors.initials: H
authors.lastname: Pambou-Tchivounda
authors.forename: M
authors.initials: M
authors.lastname: Baldy-Moulinier
authors.forename: B
authors.initials: B
authors.lastname: Koudogbo
authors.forename: C
authors.initials: C
authors.lastname: N'Guemby-Bina
mesh_terms: D000350:Africa, Central; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D000431:Ethanol; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D000431:Ethanol