title: [Plasmapheresis in the combined therapy of progressive forms of glomerulonephritis].
abstract: 29 patients aged 6-16 with glomerulonephritis lasting 4-5 years received multimodality treatment with plasmapheresis as a component. The majority of the patients suffered from primary glomerulonephritis in mesangio- or membrano-proliferative morphological variants. Previous long-term conventional therapy (prednisolone, cytostatics, anticoagulants and antiaggregation drugs) failed. The test course comprised 1-3 plasmapheresis sessions (centrifuge method on [symbol: see text] apparatus), cyclophosphamide or maintenance methyl-prednisolone pulse therapy, heparin and curantil. One-third of the patients achieved remission lasting from 5 months to 3 years, in the other one-third the improvement was as short as 2-4 weeks, and the last one-third appeared non-responders. Improvement of clinical indices occurred in parallel with trends to reduction in the levels of CIC, IgG, B-lymphocytes, T-helpers, inhibition of lymphocyte succinate dehydrogenase activity, better phagocytosis. No complications which may prohibit plasmapheresis use in glomerulonephritis were observed. Adjuvant plasmapheresis use in glomerulonephritis treatment needs further studies.
authors.forename: E S
authors.initials: ES
authors.lastname: Moskaleva
authors.forename: M S
authors.initials: MS
authors.lastname: Ignatova
authors.forename: V A
authors.initials: VA
authors.lastname: Korneeva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Muromtsev
authors.forename: E I
authors.initials: EI
authors.lastname: Tsvetkova
authors.forename: N M
authors.initials: NM
authors.lastname: Parubinovskaia
authors.forename: E A
authors.initials: EA
authors.lastname: Kharina
authors.forename: O V
authors.initials: OV
authors.lastname: Katysheva
authors.forename: A V
authors.initials: AV
authors.lastname: Krivonos
mesh_terms: D000293:Adolescent; D000917:Antibody Formation; D002648:Child; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005921:Glomerulonephritis / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007111:Immunity, Cellular; D010956:Plasmapheresis / Q000295:instrumentation; D012074:Remission Induction; D013997:Time Factors
vernacular_title: Plazmaferez v kompleksnoĭ terapii progressiruiushchikh form glomerulonefrita.