title: [Effects of physical activity on lipids and coagulation].
abstract: In order to evaluate the effects of physical activity on seric lipoproteins and coagulation parameters, an 8-week clinical trial was performed. Fifteen healthy young subjects (average age 23 years) with no history of previous agonistic physical activity, entered the study. Each subject underwent a physical programme consisting of three times a week bicycle ergometer exercise with progressive increases in work rate by using stages of 3 min duration until the 85% of the predictive heart rate was reached. Each individual was subjected to four blood drawings according to the following schedule: at the beginning of the study, after 4 weeks, after 8 weeks (at the end of the programme) and 4 weeks after the interruption of training. As far as the seric lipoproteins are concerned, the following parameters were monitored: total cholesterol, HDL-C, LDL-C, VLDL-C, triglycerides, Apo-A1, Apo-B100, NEFA and phospholipids. On the other hand the following coagulation parameters were monitored: fibrinogen PT, aPtt, coagulation factors (II-XII), red cells, leucocytes, platelets, hemoglobin and hematocrit. From the analysis of the data, the following statistically significant results were observed: HDL-C increased by 14%, LDL-C decreased by 13%, Apo-A1 increased by 6%, fibrinogen increased by 31.7%, Ptt decreased by 3.7% and leucocytes increased by 15%. Four weeks after exercise was terminated, all monitored parameters turned into the basal range. Our data seem to demonstrate a positive effect of physical exercise on seric lipoproteins in the short period. Nevertheless they provide evidence of an hypercoagulability condition demonstrated by the important fibrinogen increase and the Ptt decrease.
authors.affiliation: Dipartimento di Medicina Interna, Università degli Studi Tor Vergata.
authors.forename: V
authors.initials: V
authors.lastname: Sanguigni
authors.forename: M
authors.initials: M
authors.lastname: Gallù
authors.forename: R
authors.initials: R
authors.lastname: De Cristofaro
authors.forename: M P
authors.initials: MP
authors.lastname: Ruffini
authors.forename: C
authors.initials: C
authors.lastname: Levi
authors.forename: L
authors.initials: L
authors.lastname: Sciarra
authors.forename: S
authors.initials: S
authors.lastname: Novo
authors.forename: A
authors.initials: A
authors.lastname: Strano
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D005082:Physical Exertion; D013997:Time Factors
chemical_list: D008055:Lipids; D008074:Lipoproteins; D002784:Cholesterol
vernacular_title: Effetto dell'attività fisica sull'assetto lipidico e sulla coagulazione.