Refined mapping of the human Ets-related gene Elk-1 to Xp11.2-p11.4, distal to the OATL1 region.
The gene for human Elk-1, an Ets-related transcription factor, has previously been localized to a region that lies on the short arm of chromosome X and that is involved in specific chromosomal translocations associated with synovial sarcoma and renal adenocarcinomas. We have used fluorescence in situ hybridization and a panel of tumor-derived somatic cell hybrids to refine the localization of Elk-1, in particular with regard to the rearrangements in these tumors. Elk-1 has been assigned to Xp11.2-p11.4, distal to the OATL1 region.
Janz
M
M
Institut für Molekularbiologie, Hannover, Germany.
Lehmann
U
U
Olde Weghuis
D
D
de Leeuw
B
B
Geurts van Kessel
A
A
Gilgenkrantz
S
S
Hipskind
R A
RA
Nordheim
A
A
D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D004268:DNA-Binding Proteins; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics; D011518:Proto-Oncogene Proteins; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics*; D013584:Sarcoma, Synovial / Q000235:genetics; D014157:Transcription Factors; D014158:Transcription, Genetic; D014178:Translocation, Genetic; D014960:X Chromosome; D050807:ets-Domain Protein Elk-1
D004268:DNA-Binding Proteins; C494112:ELK1 protein, human; D011518:Proto-Oncogene Proteins; D015682:Retroviridae Proteins, Oncogenic; D014157:Transcription Factors; D050807:ets-Domain Protein Elk-1