title: Primary disseminated form of Ewing sarcoma in association with hypercalcemia and acute renal failure.
abstract: We present a case of an extremely rare form of Ewing sarcoma--primary disseminated, with fulminating course, severe hypercalcemia, extensive calcium deposition in parenchymatous organs, including kidneys, and acute renal failure as a clinical consequence. Correction of hypercalcemia was followed by prompt restoration of the glomerular filtration rate (GFR), suggesting that hypercalcemia had a direct effect on its regulation independent of the renal tubular damage. The effectiveness of the treatment with indomethacin indirectly supports the possibility of prostaglandin-mediated humoral hypercalcemia of malignancy.
authors.affiliation: Department of Nephrology, Faculty of Medicine, St. Cyril and Methodius, University of Skopje, R. Macedonia.
authors.forename: L A
authors.initials: LA
authors.lastname: Lozance
authors.forename: K G
authors.initials: KG
authors.lastname: Zafirovska
authors.forename: S V
authors.initials: SV
authors.lastname: Bogdanovska
authors.forename: G J
authors.initials: GJ
authors.lastname: Zafirovski
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology*; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D007213:Indomethacin / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D012512:Sarcoma, Ewing / Q000150:complications*
chemical_list: D010281:Parathyroid Hormone; D011458:Prostaglandins E; D007213:Indomethacin