title: Prospective study of factors predicting outcome of transdermal nicotine treatment in smoking cessation.
abstract: OBJECTIVE
  To assess the factors associated with cessation of smoking with transdermal nicotine and brief behavioural counselling.
  
  
  METHODS
  Interviews, treatment, and follow up for 26 weeks.
  
  
  METHODS
  1481 subjects recruited by mass media publicity who smoked > or = 15 cigarettes a day and were motivated to stop smoking.
  
  
  METHODS
  Twelve weeks' treatment with transdermal nicotine and brief behavioural counselling at monthly visits.
  
  
  METHODS
  Sustained smoking cessation for the 28 days before the visit at week 26 verified by expired carbon monoxide concentrations. The logistic regression analysis included all subjects.
  
  
  RESULTS
  Most subjects were dependent on nicotine, and the mean (SD) number of cigarettes smoked a day was 32 (12). Overall, 316/1481 subjects (21.3%) stopped smoking. Factors associated with stopping were being male (adjusted odds ratio 2.0; 95% confidence interval 1.5 to 2.7), age > or = 40 years (1.5; 1.1 to 2.0), living with a spouse or partner (1.5; 1.1 to 2.1), motivation ("want to quit" 1.7; 1.2 to 2.3), and concern about weight gain (1.7; 1.3 to 2.2). Negative associations were smoking marijuana (0.4; 0.2 to 0.8) and the presence of other smokers in the household (0.8; 0.6 to 0.9). Almost all subjects who smoked three or more cigarettes in the first four weeks of treatment resumed smoking in the long term (525/547, 96%).
  
  
  CONCLUSIONS
  Age, sex, marital status (living with a spouse or partner), motivation, concern about weight gain, recent marijuana smoking, and other smokers in the household were baseline factors associated with differences in outcome of smoking cessation attempts. Smoking three or more cigarettes in the first few weeks after stopping strongly predicted long term relapse.
authors.affiliation: Department of Social and Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: S G
authors.initials: SG
authors.lastname: Gourlay
authors.forename: A
authors.initials: A
authors.lastname: Forbes
authors.forename: T
authors.initials: T
authors.lastname: Marriner
authors.forename: D
authors.initials: D
authors.lastname: Pethica
authors.forename: J J
authors.initials: JJ
authors.lastname: McNeil
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003376:Counseling; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008385:Marijuana Smoking; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage*; D010349:Patient Compliance; D011446:Prospective Studies; D012008:Recurrence; D012737:Sex Factors; D012907:Smoking / Q000503:physiopathology; D016540:Smoking Cessation / Q000379:methods / Q000523:psychology; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D009538:Nicotine