title: Modification of testicular cytochrome P-450 after fenitrothion administration.
abstract: 1. The effect of fenitrothion on testicular microsomal system was analyzed and compared to the modifications induced by the drug at the hepatic level. 2. Acute (165 mg/kg, 1 day) and subacute (55 mg/kg, 3 days) administration of fenitrothion caused a significant decrease on testicular cytochrome P-450 content (51 and 50% respectively) but no modification on cytochrome b5 and NADPH cytochrome c reductase. No changes were induced by fenitrothion in testicular microsomal system after chronic treatment (5.5 mg/ml, 30 days). 3. Results obtained in the liver were very similar to those observed in testis even though the percentage of cytochrome P-450 inhibition obtained after acute and subacute drug administration (45 and 43%) was smaller. 4. In addition, changes in testosterone blood concentrations were also analyzed. A significant reduction of hormone plasma levels were detected at 165 and 55 mg/kg doses of fenitrothion (98% in both cases). Fenitrothion was not able to modify the levels of testosterone in the blood after chronic administration.
authors.affiliation: Departament de Farmacologia i Psiquiatria, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: M V
authors.initials: MV
authors.lastname: Clos
authors.forename: M
authors.initials: M
authors.lastname: Ramoneda
authors.forename: G
authors.initials: G
authors.lastname: Garcia
mesh_terms: D000728:Androgens / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects*; D005278:Fenitrothion / Q000494:pharmacology*; D006900:Hydroxylation; D008297:Male; D008861:Microsomes / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000187:drug effects* / Q000201:enzymology; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D000728:Androgens; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D005278:Fenitrothion