Spiperone binding capacity in lymphocytes of patients with alcohol- and drug-induced psychosis: preliminary results.
An increased spiperone binding capacity in lymphocytes has been proposed as a possible biological marker for schizophrenia while in previous studies patients with alcohol dependence were shown to have a normal binding capacity. In a pilot study the spiperone binding capacity was studied in 8 patients with alcohol hallucinosis, 11 patients with acute drug-induced psychosis and 12 patients with other organic psychosis. An increased binding capacity, defined as > 4 fmol/l E6 cells, was found in only 1 patient with alcohol hallucinosis, 3 patients with drug-induced psychosis and 2 patients with other organic psychosis. Possible implications of these findings for future research are discussed.
Soyka
M
M
Psychiatische Klinik und Poliklinik, Universität München, Federal Republic of Germany.
Bondy
B
B
Peuker
B
B
Ackenheil
M
M
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006212:Hallucinations / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000097:blood / Q000175:diagnosis; D010865:Pilot Projects; D011604:Psychoses, Alcoholic / Q000097:blood / Q000175:diagnosis*; D011605:Psychoses, Substance-Induced / Q000097:blood / Q000175:diagnosis*; D011954:Receptors, Dopamine / Q000378:metabolism*; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood / Q000175:diagnosis; D013134:Spiperone / Q000493:pharmacokinetics*
D011954:Receptors, Dopamine; C031611:spiroperidol receptor; D013134:Spiperone