[Familial essential hypertension and HLA].
Ten families living in Shenyang city with multiple cases of essential hypertension were studied by HLA haplotype analysis. They were selected strictly in accordance with the methods of sibling pair analysis and lods analysis. The obtained ratio of HLA haplotype sharing among affected siblings were 28.6%(2): 52.4%(1): 19.0%(0), P > 0.9. It is indicated that the haplotype shared randomly among affected siblings. The results of Lods analysis were Q = 0.40, Lods = 0.046, Pr = 1.112. These results showed that there is no evidence of patients with essential hypertension susceptible to gene linked with HLA.
Yu
G L
GL
Testing Department, Shenyang Seventh People's Hospital.
Jin
Y H
YH
Sun
Y P
YP
D000818:Animals; D004198:Disease Susceptibility; D006680:HLA Antigens / Q000235:genetics*; D006238:Haploidy; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000276:immunology*; D008126:Lod Score; D016555:Matched-Pair Analysis; D011817:Rabbits
D006680:HLA Antigens