title: Changes in debrisoquine hydroxylation capacity following liver surgery.
abstract: Liver transplantation or the surgical construction of portacaval shunts may radically alter an individual's debrisoquine hydroxylation capacity. Good clinical management should encompass a full awareness of such changing needs and problems in patients who undergo hepatic surgery.
authors.affiliation: Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Mitchell
authors.forename: R R
authors.initials: RR
authors.lastname: Shah
authors.forename: D G
authors.initials: DG
authors.lastname: Clements
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D000328:Adult; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006801:Humans; D006900:Hydroxylation; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects*
chemical_list: C012359:4-hydroxydebrisoquin; D003647:Debrisoquin