title: Imaging and differential diagnosis of the large eye.
abstract: The initial step in the differential diagnosis of an enlarged eye is to determine whether an intraocular mass is present. The globe may be expanded by a mass, seen mainly in children with retinoblastoma. Buphthalmos with or without neurofibromatosis also enlarges the eye. Diffuse enlargement may be associated with a connective tissue disorder or be related to axial myopia. Focal enlargement represents staphyloma, which can be unilateral or bilateral. In the presence of one small eye, the normal-sized eye may be incorrectly diagnosed as large.
authors.affiliation: Department of Radiology, University of North Carolina School of Medicine, Chapel Hill 27599.
authors.forename: M
authors.initials: M
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Castillo
mesh_terms: D003937:Diagnosis, Differential; D005094:Exophthalmos / Q000000981:diagnostic imaging / Q000209:etiology; D005123:Eye / Q000000981:diagnostic imaging; D005128:Eye Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D009915:Orbit / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed