title: The large granular lymphocyte syndrome with rheumatoid arthritis. Immunogenetic evidence for a broader definition of Felty's syndrome.
abstract: OBJECTIVE
  To assess whether the HLA-DR4 association found in rheumatoid arthritis (RA) is also seen in the large granular lymphocyte (LGL) syndrome.
  
  
  METHODS
  HLA-DR genotyping was performed using restriction fragment length polymorphism and polymerase chain reaction analysis.
  
  
  RESULTS
  LGL syndrome patients with RA showed the same HLA-DR4 association seen in RA/Felty's syndrome (FS), while LGL syndrome patients without arthritis did not.
  
  
  CONCLUSIONS
  It is proposed that FS and the LGL syndrome represent different variants of a broader syndrome comprising RA, neutropenia, LGL expansions, HLA-DR4 positivity, and splenomegaly.
authors.affiliation: UMDS, London, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Bowman
authors.forename: M
authors.initials: M
authors.lastname: Sivakumaran
authors.forename: N
authors.initials: N
authors.lastname: Snowden
authors.forename: M
authors.initials: M
authors.lastname: Bhavnani
authors.forename: M A
authors.initials: MA
authors.lastname: Hall
authors.forename: G S
authors.initials: GS
authors.lastname: Panayi
authors.forename: J S
authors.initials: JS
authors.lastname: Lanchbury
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D005258:Felty Syndrome / Q000235:genetics / Q000276:immunology; D005260:Female; D015804:HLA-DR4 Antigen / Q000032:analysis; D006720:Homozygote; D006801:Humans; D016130:Immunophenotyping; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications; D013577:Syndrome
chemical_list: D015804:HLA-DR4 Antigen