Drugs and the kidney.
Renal insufficiency affects every organ system and every aspect of drug disposition by the body. Because the kidney is the organ responsible for the elimination of most drugs or their metabolites from the body, renal dysfunction results in substantial changes in drug therapy. Furthermore, the kidney is often a target organ for the expected physiological effects of the drugs that are given or for their toxicity. Finally, our therapeutic options for treating uremia complicate drug therapy by further changing drug disposition. This article reviews recent work aimed at understanding these processes.
Aronoff
G R
GR
Kidney Disease Program, University of Louisville, KY 40292.
D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism*; D010599:Pharmacokinetics