Automated flow-injection technique for use in dissolution studies of sustained-release formulations: application to iron(II) formulations.
The application of flow-injection analysis (FIA) to automated dissolution studies of sustained-release formulations is described. The long-term stability of the dissolution-FIA analyser was checked during unattended operation for 42 h. The construction of multiple calibration curves with the so-called electronic dilution FIA procedure was used to extend the linear range of the determination. The computer-controlled FIA system and the principles of associated software are described and applied to dissolution studies of sustained-release formulations of iron(II) using its sensitive reaction with the colour reagent, ferrozine. The extended linear range of the determination is 1-130 ppm iron(II) and the precision (RSD) better than 3% (n = 3).
Georgiou
C A
CA
Department of Chemistry, University of Athens, Panepistimiopolis, Kouponia, Greece.
Valsami
G N
GN
Macheras
P E
PE
Koupparis
M A
MA
D002138:Calibration; D003692:Delayed-Action Preparations; D005296:Ferrous Compounds / Q000032:analysis / Q000378:metabolism*; D005297:Ferrozine / Q000737:chemistry; D017022:Flow Injection Analysis / Q000379:methods*; D008838:Microcomputers; D015203:Reproducibility of Results; D012995:Solubility
D003692:Delayed-Action Preparations; D005296:Ferrous Compounds; D005297:Ferrozine; C020748:ferrous sulfate