title: Discordant birthweight and late fetal death in like-sexed and unlike-sexed twin pairs: a population-based study.
abstract: OBJECTIVE
  To study the relation between pregnancy loss (one or two fetal deaths in a pair) in twin pregnancy and gender (like-sexed and unlike-sexed pairs), discordant birthweight, and placentation.
  
  
  METHODS
  The type of placentation for gestations with pregnancy loss was studied, based on material retrieved from the original medical records, for a defined region comprising 20.0% of the total twin population.
  
  
  METHODS
  Four thousand one hundred and ninety-one unlike-sexed and 10,875 like-sexed twin pairs born in Sweden between 1973 and 1989, in most cases with a gestational duration 28 or more completed weeks.
  
  
  RESULTS
  The relative risk (RR) for pregnancy loss in like-sexed pairs, compared with unlike-sexed ones, was 2.3 and the 95% confidence limits (CL) 1.7-3.1. Not until discordance exceeded 999 g did the pregnancy loss rate for unlike-sexed pairs increase significantly, compared with the (first) stratum with discordance less than 250 g (RR = 6.3; CL 3.5-11.3). For like-sexed twin pairs a higher pregnancy loss rate, compared with the first stratum, was seen already in the stratum with discordance 250-499 g (RR = 1.3; CL 1.0-1.8); a significant increase in pregnancy loss rate was found in all the three strata 500-749 g (RR = 2.1; CL 1.5-3.0), 750-999 g (RR = 3.5; CL 2.3-3.0), and 1000 g or more (RR = 10.9; CL 8.4-14.2), respectively. When calculating the discordance as a percentage of the weight of the larger twin, unlike-sexed pairs experienced a significant increase in pregnancy loss when discordance exceeded 40 to 50%. For like-sexed ones, the corresponding figures were 20 to 30%. In the 47 unlike-sexed pregnancies complicated by pregnancy loss, both twins died in two pregnancies (4.3%), whereas for like-sexed pairs the corresponding figures were 65/279 (23.3%). Of 47 gestations with pregnancy loss in a defined region, 32 were monochorionic (monozygous), nine were like-sexed dichorionic (monozygous or dizygous), and six were unlike-sexed (dizygous).
  
  
  CONCLUSIONS
  Pregnancy loss was twice as high in like-sexed compared with unlike-sexed pairs, and only in like-sexed pairs was pregnancy loss strongly correlated to birthweight discordance. In twin pregnancies with one fetal death the risk for the surviving twin to succumb is five to six times higher in like-sexed compared with unlike-sexed pairs and is most probably related to monochorionicity.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital, Lund, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Rydhström
mesh_terms: D001724:Birth Weight; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D006801:Humans; D010929:Placentation; D011159:Population Surveillance; D011247:Pregnancy; D012307:Risk Factors; D012737:Sex Factors; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic