title: [Multiple myeloma with numb chin syndrome as the initial manifestation].
abstract: The numb chin syndrome (NCS) is characterized by chin or lower lip numbness restricted to the distribution of the mental nerve (the distal trigeminal nerve). A case of multiple myeloma with polycythemia vera was diagnosed with NCS as the initial manifestation. A 73-year-old Japanese male was admitted to our hospital in April, 1993, because of paresthesia around the chin and lower lip. X-ray film showed multiple osteolytic lesions. According to serum and urine immunoelectrophoresis, lambda type Bence Jones protein was demonstrated. The bone marrow aspiration showed the normocellular marrow with 14.1% myeloma cells. He was diagnosed a suffering from multiple myeloma and was treated with melphalan and prednisolone. He is alive at present with resolution of NCS. We discussed pathogenesis, diagnosis, and treatment of NCS.
authors.affiliation: Third Department of Internal Medicine, Hokkaido University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Shiroshita
authors.forename: M
authors.initials: M
authors.lastname: Kurosawa
authors.forename: M
authors.initials: M
authors.lastname: Okabe
authors.forename: M
authors.initials: M
authors.lastname: Chuuma
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Sakurada
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
mesh_terms: D000368:Aged; D002680:Chin / Q000294:innervation*; D003389:Cranial Nerve Diseases / Q000209:etiology; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D010292:Paresthesia / Q000209:etiology; D012677:Sensation; D013577:Syndrome; D014276:Trigeminal Nerve