[A comparison between propafenone and amiodarone in the conversion to sinus rhythm of atrial fibrillation of recent onset].
The effectiveness of propafenone versus amiodarone for conversion to sinus rhythm of paroxysmal atrial fibrillation was compared. Fifty-four consecutive adult patients affected by recent onset atrial fibrillation (< 7 days) were randomized to treatment with intravenous propafenone (27 patients) and amiodarone (27 patient). Sinus rhythm was restored respectively in 74.1% and 70.4% (p = ns); within 5 hours was obtained reconversion in 65% of propafenone and in 15.8% of amiodarone group (p < 0.05); the mean conversion time was 3.5 and 16.6 hours (p < 0.01). In conclusion propafenone seems to be as effective and safe as amiodarone, but is significantly fast in converting recent onset atrial fibrillation to sinus rhythm.
Treglia
A
A
Sezione Autonoma di Cardiologia, Presidio Ospedaliero di Formia, Regione Lazio, USL LT/6, Latina.
Alfano
C
C
Rossini
E
E
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011405:Propafenone / Q000008:administration & dosage*; D013997:Time Factors
D011405:Propafenone; D000638:Amiodarone
Confronto tra propafenone ed amiodarone nella conversione al ritmo sinusale della fibrillazione atriale di recente insorgenza.