Prolactin-brain interactions in the induction of material behavior in rats.
Most adult female mammals display an immediate onset of maternal care toward their offspring at parturition, whereas the responses of inexperienced, nulliparous females are often less intense or absent. The shift from being a slow or nonresponder in nulliparous females to a rapid responder at parturition in primiparous animals is induced in part by the endocrine changes of pregnancy. This report reviews recent evidence demonstrating a role for prolactin in the stimulation of maternal behavior in the rat. Moreover, new findings are presented that indicate that endogenous rat prolactin acts centrally to stimulate maternal behavior in steroid-primed, nulliparous rats and that the ventromedial hypothalamus in addition to the medial preoptic area are important neural substrates regulating the rapid induction of maternal behavior at parturition.
Bridges
R S
RS
Department of Comparative Medicine, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536.
Mann
P E
PE
D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D008425:Maternal Behavior; D010928:Placental Lactogen / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011301:Preoptic Area / Q000502:physiology; D011388:Prolactin / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology
D011388:Prolactin; D010928:Placental Lactogen