Regulation of B-cell activation by CD45: a question of mechanism.
Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function?
Justement
L B
LB
Dept of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555-1019.
Brown
V K
VK
Lin
J
J
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D017493:Leukocyte Common Antigens / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D011505:Protein-Tyrosine Kinases / Q000276:immunology*
D011505:Protein-Tyrosine Kinases; D017493:Leukocyte Common Antigens