Does ranitidine affect blood alcohol concentrations?
No interaction occurs between ranitidine and alcohol when alcohol 0.3 g/kg or more is taken by either fed or fasted subjects. Ranitidine is associated with small increases (2-4 mg/dl) in blood alcohol concentrations in subjects given alcohol 0.15 g/kg under specific experimental conditions. Mean peak blood alcohol concentrations nevertheless remain low (< 20 mg/dl) after the amount, which is equivalent to about 3 oz of wine or 1 oz of 80-proof liquor. Such changes also occur when alcohol is ingested after different types of foods, and are smaller than the increases when it is drunk on an empty compared with a full stomach. The pharmacokinetic effect seen with ranitidine is without apparent clinical or social significance.
Pipkin
G A
GA
Department of Gastroenterology, Glaxo Research and Development, Ltd., Uxbridge, United Kingdom.
Mills
J G
JG
Wood
J R
JR
D000428:Alcohol Drinking / Q000097:blood / Q000378:metabolism; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood* / Q000378:metabolism; D005215:Fasting / Q000097:blood; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000097:blood / Q000494:pharmacology*
D000431:Ethanol; D011899:Ranitidine