title: The effects of improved hemodynamics on aortic dimensions in patients undergoing heart transplantation.
abstract: OBJECTIVE
  Retrospective studies have demonstrated an accelerated growth rate of abdominal aortic aneurysms in heart transplant patients. This prospective study was undertaken to define the relationship between cardiac hemodynamics and posttransplant aortic dilation.
  
  
  METHODS
  Sixty-eight patients undergoing heart (n = 60) or heart-lung (n = 8) transplantation were prospectively evaluated with abdominal ultrasonography before transplantation and annually after transplantation. Risk factors implicated in aneurysm growth, including age, indication for transplantation, immunosuppression, posttransplantation hypertension, and abdominal aortic dimension before transplantation were recorded. All patients underwent annual coronary artery catheterization and multiple gated acquisition scanning.
  
  
  RESULTS
  Thirty-seven patients (54%) had no change in aortic diameter after transplantation (pretransplantation and posttransplantation diameter = 1.8 +/- 0.3 cm), over a mean follow-up period of 28 +/- 14 months. In the remaining 31 (46%) patients, aortic diameter increased by 0.5 +/- 0.6 cm over 31 +/- 15 months (p < 0.05). Four (6%) of these 31 patients had abdominal aortic aneurysms (mean aortic diameter = 5.0 +/- 0.8 cm). The mean increase in aortic diameter among these 4 patients was 1.8 +/- 0.2 cm (annual rate of growth = 0.96 +/- 0.3 cm/year). Patients experiencing an increase in aortic dimension after transplantation had significantly lower (p < 0.005) pretransplantation ejection fractions (17.1% +/- 10.5% vs 28.6% +/- 18.1%) and, as a consequence, significantly greater (p < 0.05) increases in their ejection fractions after transplantation compared with patients with stable aortic dimensions (42.7% +/- 12.6% vs 31.8% +/- 18.0%).
  
  
  CONCLUSIONS
  Of 68 heart transplant patients prospectively evaluated, aortic diameter increased in 31 (46%); new aneurysms developed in four of these patients. Greater incremental increases in cardiac ejection fraction were significant correlates with aortic enlargement.
authors.affiliation: Department of Surgery, University of Utah, Salt Lake City.
authors.forename: D A
authors.initials: DA
authors.lastname: Bull
authors.forename: L A
authors.initials: LA
authors.lastname: Neumayer
authors.forename: B J
authors.initials: BJ
authors.lastname: Venerus
authors.forename: C W
authors.initials: CW
authors.lastname: Putnam
authors.forename: L
authors.initials: L
authors.lastname: Rosado
authors.forename: P
authors.initials: P
authors.lastname: Lund
authors.forename: K E
authors.initials: KE
authors.lastname: McIntyre
authors.forename: V M
authors.initials: VM
authors.lastname: Bernhard
authors.forename: J G
authors.initials: JG
authors.lastname: Copeland
authors.forename: G K
authors.initials: GK
authors.lastname: Sethi
mesh_terms: D000328:Adult; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D004108:Dilatation, Pathologic; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D011300:Preoperative Care; D011446:Prospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D014463:Ultrasonography