Intralesional corticosteroid therapy for childhood cutaneous hemangiomas.
Response to intralesional steroid therapy (triamcinolone acetonide and betamethasone acetate) was studied in 70 children of all ages with 74 cutaneous hemangiomas located in a variety of locations. One to seven injections were given without anesthesia with a mean interval of 6 weeks between the injections. Results analyzed 2 months after the last injection showed more than 75% reduction in volume in 43 (58.11%), 50% to 75% reduction in 16 (21.62%), 25% to 50% reduction in 9 (12.16%), and less than 25% reduction in 6 (8.11%) lesions. Response was not related to age, sex, or site of the lesion, but only 2 lesions (22.22%) with an initial volume of more than 20 cm3 showed more than 50% reduction. None showed regrowth within a mean follow-up period of 14 months. Transient cushingoid faces and hypopigmentation were noted in 2 patients each. We feel that intralesional steroid therapy is safe and effective for all cutaneous hemangiomas irrespective of site, sex, or age of the patient.
Chowdri
N A
NA
Department of Plastic and Reconstructive Surgery, S.K. Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Darzi
M A
MA
Fazili
Z
Z
Iqbal
S
S
D001623:Betamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D018324:Hemangioma, Capillary / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D008297:Male; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000627:therapeutic use
D004338:Drug Combinations; D001623:Betamethasone; D014222:Triamcinolone Acetonide