Amniotic fluid volume reflects recent glycemic status in gestational diabetes mellitus.
OBJECTIVE
Our purpose was to determine the association between amniotic fluid volume and recent glucose status in gestational diabetes.


METHODS
Serial amniotic fluid index values, mean blood glucose levels, and percent hyperglycemia (> or = 120 mg/dl) 1 day and 1 week before the ultrasonographic examinations were prospectively collected in 399 gestational diabetics. Patients demonstrating at least one amniotic fluid index measurement within the normal range (i.e., 5 cm < amniotic fluid index < or = 20 cm) and at least one elevated measurement (i.e., amniotic fluid index > 20 cm) formed the study group. With each patient serving as her own control, glucose index values preceding normal and elevated amniotic fluid index values were compared.


RESULTS
Significantly higher mean blood glucose values 1 day (114.7 mg/dl vs 102.8 mg/dl, p < 0.01) and 1 week before (111.0 mg/dl vs. 102.0 mg/dl, p < 0.05) were calculated for examinations resulting in elevated amniotic fluid index values compared with normal amniotic fluid index values, respectively. Similarly, significantly higher percents of hyperglycemia 1 day (32% vs 16.5%, p < 0.05) but not 1 week (30.8% vs 21.7%, p > 0.05) before the elevated amniotic fluid index were documented.


CONCLUSIONS
Amniotic fluid volume reflects recent glycemic status in gestational diabetes mellitus.
Bar-Hava
I
I
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461.
Scarpelli
S A
SA
Barnhard
Y
Y
Divon
M Y
MY
D000328:Adult; D000653:Amniotic Fluid / Q000000981:diagnostic imaging*; D001786:Blood Glucose / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D011247:Pregnancy; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal
D001786:Blood Glucose