title: Prevalence of ciprofloxacin resistance in multiresistant gram-negative intensive care unit isolates.
abstract: Of 107 gram-negative isolates obtained from intensive care units examined for patterns of multiresistance to 16 antimicrobial agents, 54.2% were multiresistant, defined as resistant to three or more test antimicrobials. Ciprofloxacin had excellent activity against all isolates with 93.4% susceptibility. Ciprofloxacin also performed well on multiresistant isolates with 89.7% susceptibility, which included 42.2% inducible Enterobacteriaceae. All six multiresistant ciprofloxacin-resistant isolates were resistant to five or more of the tested antimicrobials (mean 9.0), including a highly resistant Proteus mirabilis urine isolate resistant to 14 of 16 agents. The only antimicrobial to which all of the ciprofloxacin-multi-resistant isolates were resistant, was ampicillin, indicating an absence of cross resistance. In addition, ciprofloxacin had excellent activity (100% susceptibility) against Enterobacter spp. and Klebsiella pneumoniae, two organisms frequently associated with nosocomial infections.
authors.affiliation: Illinois Masonic Medical Center, Dept. of Pathology, Chicago, IL 60657.
authors.forename: C M
authors.initials: CM
authors.lastname: Khurana
authors.forename: B R
authors.initials: BR
authors.lastname: Wojack
mesh_terms: D002939:Ciprofloxacin / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D018432:Drug Resistance, Multiple; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D015994:Incidence; D017053:Infection Control; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D015995:Prevalence
chemical_list: D002939:Ciprofloxacin