[A study on chemoprevention of retinamide II from cervical precancerous lesions].
The patients with cervical precancerous lesions were double-blindly randomized into two groups. The one was treated with retinamide II (RII) suppository intravaginally and the other with placebo, once daily for 50 days as a course. The results showed precancerous lesions in 68.57% of the patients disappeared, with an overall effective rate of 74.29% after two-course treatment with RII. Its long-term curative effect approximated to that with laser beam radiation and electrocautery (P > 0.05), and differed significantly (P < 0.01) from that with common antiphlogistic. So, RII can be used as a major measure in prevention and treatment for cervical cancer in high-incidence areas in our country.
Chen
R D
RD
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Ding
A H
AH
Han
R
R
D000282:Administration, Intravaginal; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D013488:Suppositories; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000517:prevention & control*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000517:prevention & control*
D013488:Suppositories; D014212:Tretinoin; C054441:retinamide