title: Establishment of initial asymmetry in early Caenorhabditis elegans embryos.
abstract: The Caenorhabditis elegans embryo has anterior/posterior, dorsal/ventral, and left/right axes that correspond to spatially asymmetric patterns of cell differentiation. Recent studies have provided insight into how the different embryonic axes are determined and have shown that the products of the glp-1, skn-1, cap-1, and cap-2 genes appear to be distributed asymmetrically in the early embryo. These gene products should provide important tools for understanding how asymmetries are established initially in nematode embryogenesis.
authors.affiliation: Department of Basic Science, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
authors.forename: J R
authors.initials: JR
authors.lastname: Priess
mesh_terms: D000818:Animals; D001757:Blastomeres / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000196:embryology*; D029742:Caenorhabditis elegans Proteins; D016764:Cell Polarity / Q000235:genetics; D004268:DNA-Binding Proteins; D004627:Embryonic Induction / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth; D015801:Helminth Proteins / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D009024:Morphogenesis / Q000235:genetics; D011506:Proteins / Q000378:metabolism; D051880:Receptors, Notch; D014157:Transcription Factors
chemical_list: D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; C060620:Glp-1 protein, C elegans; D015801:Helminth Proteins; D008562:Membrane Glycoproteins; D011506:Proteins; D051880:Receptors, Notch; D014157:Transcription Factors; C489099:cap-1 protein, C elegans; C489098:cap-2 protein, C elegans; C073702:skn-1 protein, C elegans