title: Evaluation of the onset and intubation conditions of rocuronium bromide.
abstract: Rocuronium 0.6, 0.75, or 0.9 mg kg-1, was given after supramaximal train-of-four stimulation of the ulnar nerve, measuring the compound action potential of the hypothenar muscles, Intubation conditions, onset time, recovery to 25% and recovery index of the three doses of rocuronium bromide were determined in 60 ASA I or II consenting patients, who were receiving propofol, alfentanil and N2O/O2 for ophthalmic surgery. Intubation conditions were randomly assessed either 45 s or 60 s after injection. In general, intubation conditions were excellent or good; in only three patients were poor conditions obtained, always at 45 s. For total intubation score a borderline difference was found in favour of the 60 s subgroups. No difference could be shown between the three dose groups. The onset time was longer (P < 0.01) in the 0.6 mg kg-1 group, compared to that in the 0.9 mg kg-1 group. The recovery to 25% and spontaneous recovery index were shorter in the 0.6 mg kg-1 group (P < 0.01).
authors.affiliation: Department of Anaesthesiology, University Hospital, Ghent, Belgium.
authors.forename: J C
authors.initials: JC
authors.lastname: De Mey
authors.forename: M
authors.initials: M
authors.lastname: Debrock
authors.forename: G
authors.initials: G
authors.lastname: Rolly
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D000368:Aged; D000732:Androstanols / Q000008:administration & dosage / Q000494:pharmacology*; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D004576:Electromyography; D005260:Female; D006225:Hand; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000077123:Rocuronium; D013997:Time Factors; D014459:Ulnar Nerve / Q000502:physiology
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium