title: Rabbit gastric lipase in biocatalytic resolution of 2-hydroxyalkyldiphenylphosphines.
abstract: Kinetic resolution of 2-hydroxyalkyldiphenylphosphines 4 by acylation with isopropenyl acetate was carried out under rabbit gastric lipase (RGL) catalysis to give optically active 4 and the corresponding acetate, the enantioselectivity factors E ranging from 10 to 20. 1-(2-Naphthyl)ethanol and 2-[N-(ethoxycarbonyl)amino]1-butanol 7 were also resolved.
authors.affiliation: Laboratoire de Synthèse Asymétrique, URA CNRS 1497, Université Paris-Sud, Orsay, France.
authors.forename: H B
authors.initials: HB
authors.lastname: Kagan
authors.forename: M
authors.initials: M
authors.lastname: Tahar
authors.forename: J C
authors.initials: JC
authors.lastname: Fiaud
mesh_terms: D000215:Acylation; D000818:Animals; D066298:In Vitro Techniques; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D011817:Rabbits; D013237:Stereoisomerism; D013270:Stomach / Q000201:enzymology
chemical_list: D010720:Phosphines; D008049:Lipase