title: Synthesis and beta-lactamase inhibitory activity of new 6 beta-sulfonamidopenicillanic acids.
abstract: New 6 beta-aryl(alkyl)sulfonamidopenicillanic acids and their sulfoxides were synthesized by sulfonylation of 6 beta-aminopenicilanic acid or its beta-sulfoxide with an appropriate sulfonyl chloride. The corresponding 6 beta-sulfonamidopenicillanic acids sulfones were prepared by oxidation of the sulfoxides with potassium permanganate in aqueous medium. The obtained compounds reduced the minimum inhibitory concentrations of ampicillin against 8 reference and 7 clinically isolated strains.
authors.affiliation: Chemical Pharmaceutical Research Institute, Bulgarian Academy of Sciences, Sofia.
authors.forename: L S
authors.initials: LS
authors.lastname: Changov
authors.forename: B K
authors.initials: BK
authors.lastname: Vassileva-Lukanova
authors.forename: A
authors.initials: A
authors.lastname: Angelova-Galabova
authors.forename: A V
authors.initials: AV
authors.lastname: Pavlova
authors.forename: S L
authors.initials: SL
authors.lastname: Spassov
mesh_terms: D001419:Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D065093:beta-Lactamase Inhibitors
chemical_list: D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid