title: Tl-201 liver uptake for assessment of jeopardized myocardium during dipyridamole stress testing.
abstract: The current study was conducted to determine the significance of Tl-201 liver activity during 4 minute dipyridamole (DP) stress testing. Two groups of subjects were examined: group I subjects (n = 52) had electrocardiographic evidence of left ventricular hypertrophy (ECG-LVH), and group II subjects (n = 114) had no ECG-LVH. Both groups were further divided into four subgroups on the basis of Tl-201 myocardial perfusion scans: 1) no myocardial perfusion defect; 2) transient myocardial perfusion defect; 3) fixed myocardial perfusion defect; and 4) transient plus fixed myocardial perfusion defects. Tl-201 liver, heart, and lung activities were quantified in the immediate anterior planar images. Left ventricular mass was quantified using tomographic short-axis slices. In the no ECG-LVH group, Tl-201 lung-to-heart ratio was significantly increased in subjects having transient, fixed, and transient plus fixed myocardial perfusion defects when compared to no myocardial perfusion defect. Tl-201 lung-to-heart ratio did not increase in the ECG-LVH group of subjects having transient, fixed, and transient plus fixed myocardial perfusion defects. In contrast, Tl-201 liver-to-heart ratio increased in both the ECG-LVH and no ECG-LVH groups of subjects having myocardial perfusion defects when compared to subjects having negative myocardial perfusion scan. Left ventricular mass was increased in ECG-LVH subjects when compared to no ECG-LVH subjects, which might have resulted in increased Tl-201 myocardial uptake and, hence, reduced Tl-201 lung-to-heart ratio in ECG-LVH subjects having myocardial perfusion defects.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, East Carolina University School of Medicine, Greenville, NC 27858-4354.
authors.forename: G D
authors.initials: GD
authors.lastname: Arora
authors.forename: W C
authors.initials: WC
authors.lastname: Reeves
authors.forename: A
authors.initials: A
authors.lastname: Movahed
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004176:Dipyridamole; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000453:epidemiology; D008099:Liver / Q000000981:diagnostic imaging*; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013794:Thallium Radioisotopes; D013997:Time Factors
chemical_list: D013794:Thallium Radioisotopes; D004176:Dipyridamole