Comparative analysis of the three major histocompatibility complex-linked heat shock protein 70 (Hsp70) genes of the rat.
The organization of the three major histocompatibility complex (Mhc)-linked heat shock protein 70 (Hsp70) genes Hsp70-1, Hsp70-2, and Hsp70-3, and the nucleotide sequences of these genes, are presented for the rat. Hsp70-1 and Hsp70-2 gene products are identical at the amino acid level. From the pattern of sequence similarity of the orthologous Mhc-linked Hsp70 genes of rat, human, and mouse, it is concluded that the gene duplications leading to the three-gene cluster occurred before the separation of the primate and rodent lines and that the Hsp70-1 and Hsp70-2 genes of rat and human might have undergone homogenization of their sequences.
Walter
L
L
Abteilung Immungenetik, Universität Göttingen, Germany.
Rauh
F
F
Günther
E
E
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D003360:Cosmids; D008040:Genetic Linkage; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D015183:Restriction Mapping
D018840:HSP70 Heat-Shock Proteins