title: Effect of acute ventricular pressure changes on QRS duration.
abstract: The effect of acute changes in ventricular pressure is examined on the QRS duration to clarify the mechanism of ventricular pressure-related arrhythmogenesis. Ventricular pressure was changed acutely by arterial transfusion-bleeding into an open-air ventricular pressure reservoir that was either off or on a metaraminol intravenous drip. While maintaining ventricular pressure at several levels, the QRS duration was measured at 200 mm/s paper speed. The QRS duration correlated significantly with the left ventricular pressure in all 14 dogs examined. An average change in ventricular by 100 mmHg was associated with a change of about 18% in the QRS duration. An acute ventricular pressure elevation impairs the ventricular conduction, which may contribute to ventricular pressure-related arrhythmogenicity.
authors.affiliation: Department of Clinical Therapeutics, Medical School of Athens University, Ioannina, Greece.
authors.forename: D A
authors.initials: DA
authors.lastname: Sideris
authors.forename: S T
authors.initials: ST
authors.lastname: Toumanidis
authors.forename: K
authors.initials: K
authors.lastname: Kostopoulos
authors.forename: A
authors.initials: A
authors.lastname: Pittaras
authors.forename: G S
authors.initials: GS
authors.lastname: Spyropoulos
authors.forename: E B
authors.initials: EB
authors.lastname: Kostis
authors.forename: S D
authors.initials: SD
authors.lastname: Moulopoulos
mesh_terms: D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001810:Blood Volume; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D007262:Infusions, Intravenous; D008680:Metaraminol / Q000008:administration & dosage / Q000494:pharmacology; D012044:Regression Analysis; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D017725:Ventricular Pressure / Q000187:drug effects / Q000502:physiology*
chemical_list: D008680:Metaraminol