Differences in the reserpine-sensitive storage in vivo of 1-methyl-4-phenylpyridinium in rats and mice may explain differences in catecholamine toxicity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Administration of reserpine, an inhibitor of vesicular catecholamine storage, differentially reduced the accumulation of MPP+ formed from MPTP in rats and mice. The effects were most pronounced in the adrenal gland for either species. In rats, reserpine decreased striatal and hippocampal MPP+ levels while in mice reserpine did not affect the disposition of MPP+ in the striatum but decreased hippocampal MPP+. The data suggest that mice may be more sensitive to the toxicant because less striatal MPP+ appears to be stored in the reserpine-sensitive storage vesicle.
Russo
S M
SM
Cellular & Molecular Pharmacology Section, Division of Pharmacology, Wellcome Research Laboratories, Research Triangle Park, NC 27709.
Daniels
A J
AJ
Viveros
O H
OH
Reinhard
J F
JF
D015655:1-Methyl-4-phenylpyridinium / Q000378:metabolism*; D000818:Animals; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017983:Receptors, Catecholamine / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology*; D013045:Species Specificity
D017983:Receptors, Catecholamine; D012110:Reserpine; D015655:1-Methyl-4-phenylpyridinium