RNA localization. Getting to the top.
Localizing gurken mRNA dorsally in Drosophila oocytes seems to be the first step in dorsoventral polarity establishment. Gurken, which resembles TGF alpha, may signal directly to dorsal follicle cells through the receptor Top.
St Johnston
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Wellcome/CRC Institute, Cambridge, UK.
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins; D005260:Female; D015870:Gene Expression; D017344:Genes, Insect; D007301:Insect Hormones / Q000096:biosynthesis*; D009865:Oocytes / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism*; D014158:Transcription, Genetic; D016211:Transforming Growth Factor alpha; D015291:Transforming Growth Factors / Q000096:biosynthesis*
D029721:Drosophila Proteins; D007301:Insect Hormones; D012333:RNA, Messenger; D016211:Transforming Growth Factor alpha; C083730:grk protein, Drosophila; D015291:Transforming Growth Factors