Enhancement of anti-Shigella lipopolysaccharide (LPS) response by addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a LPS vaccines.
Addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a lipopolysaccharide vaccines improved their immunogenicities. Enhancement of anti-O-Shigella immunoglobulin A levels was most evident in lung lavages following oral immunization and in lung and intestinal fluids when suboptimal doses were used with either immunization route.
Orr
N
N
Medical Corps, Israel Defence Force, Military Post 02149, Rehovot, Israel.
Arnon
R
R
Rubin
G
G
Cohen
D
D
Bercovier
H
H
Lowell
G H
GH
D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D002772:Cholera Toxin / Q000276:immunology*; D005260:Female; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011510:Proteolipids; D012763:Shigella flexneri / Q000276:immunology*
D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D011510:Proteolipids; C020485:proteoliposomes; D002772:Cholera Toxin