title: Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma.
abstract: Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.
authors.affiliation: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: B
authors.initials: B
authors.lastname: Ensoli
authors.forename: R
authors.initials: R
authors.lastname: Gendelman
authors.forename: P
authors.initials: P
authors.lastname: Markham
authors.forename: V
authors.initials: V
authors.lastname: Fiorelli
authors.forename: S
authors.initials: S
authors.lastname: Colombini
authors.forename: M
authors.initials: M
authors.lastname: Raffeld
authors.forename: A
authors.initials: A
authors.lastname: Cafaro
authors.forename: H K
authors.initials: HK
authors.lastname: Chang
authors.forename: J N
authors.initials: JN
authors.lastname: Brady
authors.forename: R C
authors.initials: RC
authors.lastname: Gallo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000821:virology; D000818:Animals; D001483:Base Sequence; D002448:Cell Adhesion; D002460:Cell Line; D017364:Collagenases / Q000378:metabolism; D004789:Enzyme Activation; D016326:Extracellular Matrix Proteins / Q000502:physiology; D016222:Fibroblast Growth Factor 2 / Q000502:physiology*; D005353:Fibronectins / Q000502:physiology; D015696:Gene Products, tat / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D020780:Matrix Metalloproteinase 9; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D014066:Palatine Tonsil / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000473:pathology / Q000821:virology; D012867:Skin / Q000473:pathology; D054322:tat Gene Products, Human Immunodeficiency Virus
chemical_list: D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus; D016222:Fibroblast Growth Factor 2; D017364:Collagenases; D020780:Matrix Metalloproteinase 9