Hemodynamic effects of barnidipine hydrochloride in conscious squirrel monkeys.
1. The effects of barnidipine, a new dihydropyridine Ca2+ antagonist, on cardiovascular and renin-angiotensin-aldosterone systems were investigated in conscious squirrel monkeys. 2. Barnidipine (0.3-3 mg/kg p.o.) produced a dose-related decrease in systolic blood pressure. The hypotensive action after 3 mg/kg p.o. lasted more than 8 hr. 3. Barnidipine increased heart rate, but did not affect the PQ-interval of the electrocardiograph. 4. Barnidipine (1 and 3 mg/kg p.o.) increased plasma renin activity dose-dependently. However, it had no significant effect on plasma aldosterone concentration. 5. These results indicate that barnidipine produces a sustained hypotension without affecting atrioventricular conduction time and plasma aldosterone concentration in conscious squirrel monkeys.
Shibasaki
M
M
Cardiovascular & Atherosclerosis Research Laboratories, Tsukuba Research Center, Yamanouchi Pharmaceutical Co. Ltd, Ibaraki Prefecture, Japan.
Inagaki
O
O
Takenaka
T
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D015394:Molecular Structure; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012084:Renin-Angiotensin System / Q000187:drug effects; D012453:Saimiri
D002121:Calcium Channel Blockers; C050699:mepirodipine; D009543:Nifedipine