[The epidemiology of spondyloarthropathies among the native inhabitants of Chukotka. 2. The prevalence of HLA-B27 in the population and among spondyloarthropathy patients].
To establish the incidence of HLA-B27 among the indigenous population of Chukot Peninsula, a one-stage cross-sectional study was made of all the natives of the two settlements of eastern Chukot Peninsula (Sireniki and Novo-Chaplino). At the moment of examination altogether 640 natives lived in both settlements. Of these, 464 persons (72.5%) could be examined clinically; HLA typing could be performed in 439 persons (68.6%). Among the 439 natives examined, antigen B27 was identified in 141 cases (32.1%). Among Eskimos, the number of HLA-B27-positive individuals amounted to 39.7%, among Chukchi to 18.9% (p = 0.0005). Half-breeds occupied an intermediate position between the two groups. The frequency of NLA-B27-positive cases was 29.7% among them. 7 patients were diagnosed to have diseases belonging to the group of spondyloarthropathies. 2 persons presented with ankylosing spondyloarthritis, 2 with Reiter's syndrome, 2 with undifferentiated spondyloarthropathies and 1 with juvenile chronic arthritis. All the patients with ankylosing spondyloarthritis and Reiter's syndrome appeared HLA-B27-positive.
Benevolenskaia
L I
LI
Erdes
Sh
Sh
Krylov
M Iu
MIu
Chekalina
N A
NA
D001110:Arctic Regions / Q000453:epidemiology; D001171:Arthritis, Juvenile / Q000208:ethnology / Q000276:immunology; D016918:Arthritis, Reactive / Q000208:ethnology / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood*; D006801:Humans; D015994:Incidence; D004930:Inuit / Q000706:statistics & numerical data; D008297:Male; D044468:Native Hawaiian or Pacific Islander / Q000706:statistics & numerical data*; D015995:Prevalence; D044469:Racial Groups; D012800:Siberia / Q000453:epidemiology; D013122:Spinal Diseases / Q000208:ethnology* / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000208:ethnology / Q000276:immunology
D015796:HLA-B27 Antigen
Epidemiologiia spondiloartropatiĭ sredi korennykh zhiteleĭ Chukotki. Soobshchenie 2. Raspredelenie HLA-B27 v populiatsii i sredi bol'nykh spondiloartropatiiami.