[Studies on adjuvant chemotherapy using subserosal or submucosal administration of neocarzinostatin for gastric cancer and colorectal cancer].
The significance and effectiveness of adjuvant intraoperative chemotherapy using subserosal or submucosal administration of Neocarzinostatin (NCS) and CH 40 for gastric cancer and colorectal cancer were studied. Tissue NCS concentration of proximal lymph nodes were higher than for distant lymph nodes, while the immunocompetency of distant lymph nodes (lower NCS concentration) showed slightly higher activity than that of proximal lymph nodes. From these results, it is suggested that loco-regional administration of NCS might be effective for chemical lymph node cleaning of the cancer.
Hashimoto
T
T
Second Dept. of Surgery, Gifu University School of Medicine.
Saji
S
S
Fukada
D
D
Umemoto
T
T
Kunieda
K
K
Sugiyama
Y
Y
Asano
M
M
Chikaishi
T
T
D002244:Carbon; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D005753:Gastric Mucosa; D006801:Humans; D015552:Injections, Intralesional; D008198:Lymph Nodes / Q000378:metabolism; D008213:Lymphocyte Activation; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009353:Zinostatin / Q000008:administration & dosage* / Q000493:pharmacokinetics
D002244:Carbon; D009353:Zinostatin