title: Evaluation of the photoprotective effect of oral vitamin E supplementation.
abstract: METHODS
  Solar-induced cutaneous damage is mediated partly via oxidative pathways. Some evidence exists for a photoprotective role of antioxidants. In a double-blind, placebo-controlled study, we examined the effect of a long-term, orally administered antioxidant against UV-induced epidermal damage. Healthy human subjects supplemented their usual diet daily with either 400 IU of oral vitamin E (alpha-tocopherol acetate) or placebo over a 6-month period. Minimal erythema dose and histologic response to threefold minimal erythema dose exposure were determined at baseline, 1 month, and 6 months.
  
  
  RESULTS
  The minimal erythema dose did not vary substantially at the three time points within each treatment group or in the vitamin E-supplemented group vs the placebo group. The number of sunburn cells produced by a threefold minimal erythema dose exposure was also not significantly different between the two groups. Of note, however, vitamin E levels in plasma increased only modestly and in skin biopsy specimens were unchanged following 1 month and 6 months of supplementation.
  
  
  CONCLUSIONS
  No clinical or histologic difference in the response to UVB could be detected between the placebo and vitamin E-supplemented groups. In this small study, daily ingestion of 400 IU of oral alpha-tocopherol daily does not provide meaningful photoprotection.
authors.affiliation: US Drug Administration Human Nutrition Research Center on Aging, Tufts University, Boston, Mass.
authors.forename: K
authors.initials: K
authors.lastname: Werninghaus
authors.forename: M
authors.initials: M
authors.lastname: Meydani
authors.forename: J
authors.initials: J
authors.lastname: Bhawan
authors.forename: R
authors.initials: R
authors.lastname: Margolis
authors.forename: J B
authors.initials: JB
authors.lastname: Blumberg
authors.forename: B A
authors.initials: BA
authors.lastname: Gilchrest
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D004890:Erythema / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005527:Food, Fortified; D006801:Humans; D008297:Male; D008875:Middle Aged; D013472:Sunlight / Q000009:adverse effects*; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014810:Vitamin E