A gene coding for a high-molecular mass rhoptry protein of Plasmodium yoelii.
We describe the deduced amino acid sequence for a gene encoding a high molecular mass rhoptry protein of Plasmodium yoelii. The sequence was obtained from an EcoRI genomic clone that overlaps a short DraI fragment isolated previously. The open reading frame consists of 2294 codons and putative hydrophobic signal and membrane anchor sequences were identified. Similarity with sequence from a clone coding for part of a Plasmodium vivax reticulocyte-binding protein was noted. Based on the sequence and location of the protein and the biological properties of antibodies that react with it, we propose that this may be an erythrocyte-binding protein.
Keen
J K
JK
Division of Parasitology, National Institute for Medical Research, Mill Hill, London, UK.
Sinha
K A
KA
Brown
K N
KN
Holder
A A
AA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D015342:DNA Probes / Q000235:genetics; D016054:DNA, Protozoan / Q000235:genetics; D017125:Genes, Protozoan; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D008970:Molecular Weight; D005810:Multigene Family; D016366:Open Reading Frames; D010966:Plasmodium vivax / Q000235:genetics; D010967:Plasmodium yoelii / Q000235:genetics*; D017433:Protein Structure, Secondary; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D015342:DNA Probes; D016054:DNA, Protozoan; D008565:Membrane Proteins; D015800:Protozoan Proteins; C075483:reticulocyte-binding protein, Plasmodium vivax