title: Bovine spongiform encephalopathy surveillance in Argentina.
abstract: Bovine spongiform encephalopathy (BSE) is a new disease of cattle first described in the United Kingdom in November 1986. BSE belongs to the scrapie-related group of diseases. The epidemiological studies performed in the United Kingdom demonstrate that the BSE epidemic was caused by feeding cattle with ruminant-derived protein contaminated by a scrapie-like agent. Until June 1994, the disease had been detected in indigenous cattle in Ireland, Switzerland and France. Three cases reported in Germany, two in the Sultanate of Oman, and single cases in the Falkland Islands (Islas Malvinas), Denmark, Portugal and Canada occurred in animals imported from the United Kingdom. Several countries have implemented surveillance programmes analysing the risk factors involved in the epidemic. An analysis of risk factors conducted in Argentina shows that it is highly unlikely that BSE or scrapie exist in the country, or will arise via feed in the future. As a continuation of the analysis of risk factors, a surveillance programme was implemented in the field and in abattoirs. Specialised personnel were trained in the clinical, histopathological and biochemical detection of the disease through a network of laboratories which covered 85% of the total cattle population and 100% of the high-risk group (dairy cows over five years of age). By using a statistical procedure with reference to the bovine population in nine provinces, 1,019 brains from animals belonging to the high-risk group were selected and studied by histopathological and biochemical analyses for BSE detection. The results were negative in all cases. It can be concluded from this analysis (with a sensitivity of detection of 2.95 per 1,000, and 95% statistical confidence) that Argentina may be regarded as BSE-free, and that the importation of infected animals or by-products may represent the sole potential source of introduction of BSE infection into the country in the future.
authors.affiliation: Instituto de Virología, Centro de Investigación en Ciencias Veterinarias, Buenos Aires, Argentina.
authors.forename: A A
authors.initials: AA
authors.lastname: Schudel
authors.forename: B J
authors.initials: BJ
authors.lastname: Carrillo
authors.forename: E J
authors.initials: EJ
authors.lastname: Gimeno
authors.forename: E L
authors.initials: EL
authors.lastname: Weber
authors.forename: J
authors.initials: J
authors.lastname: Blanco Viera
authors.forename: C
authors.initials: C
authors.lastname: van Gelderen
authors.forename: E
authors.initials: E
authors.lastname: Ulloa
authors.forename: A
authors.initials: A
authors.lastname: Nader
authors.forename: B G
authors.initials: BG
authors.lastname: Cané
mesh_terms: D000003:Abattoirs; D000818:Animals; D001118:Argentina / Q000453:epidemiology; D001921:Brain / Q000473:pathology; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000453:epidemiology*; D005260:Female; D008297:Male; D012307:Risk Factors