title: Management of fulminant ulcerative colitis by primary restorative proctocolectomy.
abstract: Severe acute ulcerative colitis unresponsive to medical management is characterized by multiple associated risk factors including anemia, hypoproteinemia, and high steroid requirements when urgent surgery is required. Current surgical options include use of primary ileal pouch-anal anastomosis (IPAA) vs. historic trends favoring colectomy with ileostomy.
  
  
  OBJECTIVE
  To evaluate the efficacy of primary IPAA in patients with severe colitis, we reviewed our own experience in 20 patients with this condition.
  
  
  METHODS
  Patients undergoing primary restorative proctocolectomy included 13 males and 7 females (mean age, 30.5 +/- 2.4 years). Exclusion criteria for primary reconstruction included septic patients and patients with associated medical conditions such as pulmonary or cardiovascular disease. History of ulcerative colitis averaged 3.1 +/- 1.1 years (range, 1 month to 19 years). Preoperative mean total serum protein concentration was 5.0 +/- 0.2 g/dl, and mean albumin concentration was 2.1 +/- 0.2 g/dl, reflecting disease severity. The average daily steroid requirement at the time of urgent colectomy was 58.0 +/- 4.4 mg of prednisone (or intravenous equivalent). Primary IPAA included 18 "W" reservoirs, 1 "S" reservoir, and 1 "J" reservoir.
  
  
  RESULTS
  Major surgical complications included mild pancreatitis (10 percent), anastomotic leak (5 percent), adrenal insufficiency (15 percent), an upper gastrointestinal bleed (5 percent), and small bowel obstruction (15 percent). There were no deaths, and no patients developed pelvic sepsis or required IPAA removal. At three and twelve months, 24-hr stool frequency averaged 7.3 +/- 0.4 and 4.9 +/- 0.3, respectively. Overall day and night continence was excellent and not different from patients who underwent elective IPAA procedures for ulcerative colitis.
  
  
  CONCLUSIONS
  Improved options such as primary IPAA may be safely used in selected patients requiring urgent surgery for severe or fulminant ulcerative colitis. Medical management should be abbreviated when disease control cannot be promptly achieved.
authors.affiliation: Department of Surgery, University of Wisconsin, Madison 53792.
authors.forename: B A
authors.initials: BA
authors.lastname: Harms
authors.forename: G A
authors.initials: GA
authors.lastname: Myers
authors.forename: D J
authors.initials: DJ
authors.lastname: Rosenfeld
authors.forename: J R
authors.initials: JR
authors.lastname: Starling
mesh_terms: D000208:Acute Disease; D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D001803:Blood Transfusion; D002940:Circadian Rhythm; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy; D003113:Colonoscopy; D003131:Combined Modality Therapy; D004630:Emergencies; D005260:Female; D005500:Follow-Up Studies; D005769:Gastrointestinal Motility; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000453:epidemiology; D011241:Prednisone / Q000627:therapeutic use; D011300:Preoperative Care; D011312:Pressure; D016737:Proctocolectomy, Restorative; D012709:Serum Albumin / Q000032:analysis; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D012709:Serum Albumin; D011241:Prednisone