title: [An evaluation of the epidemiological and immunological efficacy of the vaccinal prophylaxis of diphtheria and tetanus].
abstract: The extensive use of adsorbed diphtheria-tetanus toxoid with reduced antigen content was found to be ineffective in the prophylaxis of diphtheria: 86.3% of diphtheria patients among those who had been immunized with this preparation fell only a year after the first booster immunization, and the proportion of those who proved to be unprotected against diphtheria on years 3, 4 and 5 after immunization reached, respectively, 21.0%, 35.5% and 49.4%. The number of children immunized with this preparation at common preschool institutions may reach 50% and more, and with an increase in the coverage of children with immunization from 10% to 50% the proportion of unprotected children may rise from 7.4% to 17.8%. The proportion of preschool institutions, insufficiently protected from diphtheria and, as a consequence, running a considerable risk of becoming (in case of the penetration of this infection) the foci of diphtheria, was found to reach 32.9%.
authors.forename: V I
authors.initials: VI
authors.lastname: Kriukov
authors.forename: V M
authors.initials: VM
authors.lastname: Bolotovskiĭ
authors.forename: I V
authors.initials: IV
authors.lastname: Mikheeva
authors.forename: T R
authors.initials: TR
authors.lastname: Zakharova
authors.forename: N N
authors.initials: NN
authors.lastname: Basova
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Ruut
authors.forename: L V
authors.initials: LV
authors.lastname: Iurevits
authors.forename: R G
authors.initials: RG
authors.lastname: Adamenko
authors.forename: B E
authors.initials: BE
authors.lastname: Raupov
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D004166:Diphtheria Antitoxin / Q000097:blood; D004168:Diphtheria Toxoid / Q000276:immunology*; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D004338:Drug Combinations; D004341:Drug Evaluation; D006801:Humans; D007117:Immunization, Secondary; D007844:Latvia / Q000453:epidemiology; D009031:Moscow / Q000453:epidemiology; D013742:Tetanus / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D013743:Tetanus Antitoxin / Q000097:blood; D013745:Tetanus Toxoid / Q000276:immunology*; D013997:Time Factors; D014505:Urban Population / Q000706:statistics & numerical data
chemical_list: D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid
vernacular_title: Otsenka épidemiologicheskoĭ i immunologicheskoĭ éffektivnosti vaktsinoprofilaktiki difterii i stolbniaka.