[The Ca(2+)-pump in erythrocytes is inhibited by glucose: a possible role in the pathogenesis of chronic complications in diabetes].
An animal model in vitro condition was used in experiments, the aim of which was to test the effect of typical diabetes glucose concentration on the purified and reactivated Ca(2+)-ATPase with a defined phospholipid composition. Inhibition of Ca(2+)-ATPase activity depends on glucose concentration in a time-dependent manner. It does not depend on phospholipid content, which suggests direct glycation of the enzyme. The altered activity of erythrocyte Ca(2+)-ATPase by glycation may lead in vivo to imbalance in the ionic transport and may contribute to the development of chronic complications of diabetes. (Tab. 2, Fig. 2, Ref. 16.)
Lehotský
J
J
Ustav lekárskej biochémie JLF UK v Martine, Slovakia.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000097:blood*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology*; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D010743:Phospholipids / Q000494:pharmacology; D013552:Swine
D010743:Phospholipids; D000252:Calcium-Transporting ATPases; D005947:Glucose
Ca(2+)-pumpa z erytrocytov je inhibovaná glukózou: mozná úloha v patogenéze chronických komplikácií cukrovky.