Cyclosporine increases hepatocyte synthesis of the immunosuppressive free radical nitric oxide.
Kuo
P C
PC
Standford University Medical Center, Dept. of Surgery, CA 94305.
D000704:Analysis of Variance; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D005609:Free Radicals; D009569:Nitric Oxide; D016572:Cyclosporine; D001219:Aspartate Aminotransferases