title: Biochemical and toxicological studies on the effect of high and low erucic acid rapeseed oil on rats.
abstract: Rats were fed on diets containing rapeseed oil, either containing low or high erucic acid content as well as the hydrogenated ones for 6 weeks. Body weight gain, biochemical and pathological parameters were investigated. The data showed high body weight gain for rats fed diets containing low erucic rape oil (LERo) compared with those fed either the high erucic rape oil (HERo), the hydrogenated or the partially hydrogenated oil diets. All rats showed non significant changes for total lipids, total cholesterol, GPT and GOT, except the partially hydrogenated rape oil diet which showed significant decrease for total cholesterol. Alkaline phosphatase however showed a significant decrease, while plasma phospholipids showed significant increase in rats fed on the hydrogenated oil diet. Triglycerides indicated non significant increase except in the group that received low erucic rape oil diet. Histopathological study showed changes in all tissues examined (liver and kidney).
authors.affiliation: Food Science and Nutrition Department, National Research Center, Dokki, Cairo, Egypt.
authors.forename: I H
authors.initials: IH
authors.lastname: Badawy
authors.forename: B
authors.initials: B
authors.lastname: Atta
authors.forename: W M
authors.initials: WM
authors.lastname: Ahmed
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004883:Erucic Acids / Q000494:pharmacology* / Q000633:toxicity; D005229:Fatty Acids, Monounsaturated; D007668:Kidney / Q000473:pathology; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000473:pathology; D009753:Nutritive Value; D010743:Phospholipids / Q000097:blood; D010938:Plant Oils / Q000494:pharmacology* / Q000633:toxicity; D000074262:Rapeseed Oil; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
chemical_list: D004883:Erucic Acids; D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D010743:Phospholipids; D010938:Plant Oils; D000074262:Rapeseed Oil; D014280:Triglycerides; C049811:erucic acid; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase