Production of a hemolytic factor by Candida albicans.
Candida albicans exhibits hemolytic activity when grown on glucose-enriched blood agar. This activity is present on intact organisms, and it is secreted into the culture medium. Hemoglobin released from lysed erythrocytes can restore the transferrin-inhibited growth of C. albicans. We conclude that C. albicans expresses a hemolytic factor which allows it to acquire iron from host erythrocytes.
Manns
J M
JM
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
Mosser
D M
DM
Buckley
H R
HR
D000818:Animals; D002176:Candida albicans / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006460:Hemolysin Proteins / Q000378:metabolism*; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism; D012756:Sheep
D006454:Hemoglobins; D006460:Hemolysin Proteins; D007501:Iron