Synthesis of doxorubicin-cyclodextrin conjugates.
Doxorubicin-gamma-cyclodextrin conjugates have been synthesized by the coupling of 14-bromodaunomycin with mono half-ester compounds linked to a 6-hydroxyl group of gamma-cyclodextrin. Release of drug from the conjugates in saline phosphate buffer solution and in vitro antitumor activity against L1210 leukemia cells were also investigated.
Tanaka
H
H
Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
Kominato
K
K
Yamamoto
R
R
Yoshioka
T
T
Nishida
H
H
Tone
H
H
Okamoto
R
R
D000818:Animals; D003505:Cyclodextrins / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers; D007939:Leukemia L1210 / Q000188:drug therapy
D003505:Cyclodextrins; D004337:Drug Carriers; D004317:Doxorubicin