[A sustained response in chronic hepatitis C treated with interferon].
We analyzed 27 subjects with long-term response, from a group of 110 interferon treated patients with biopsy-proven chronic hepatitis and serum anti-HCV antibodies. The following variables were assessed as potential predictors: sex, age, ALT level before the therapy was started, liver structure, type of interferon, total amount of interferon. Total amount of administered interferon statistically correlated with long-term response by univariate analysis. Nevertheless upon stepwise logistic multivariate analysis none of them was independently predictive of long-term response. Additional studies would be needed in order to develop a model capable of predicting from pre-treatment features which patients are likely to have long-term response.
Ruzza
M
M
Clinica Medica Generale, Dipartimento di Scienze Biomediche ed Oncologia Umana, Università, Novara.
Andorno
S
S
Ballarè
M
M
Brondolo
R
R
Cusumano
S
S
D'Andrea
F
F
La Terra
G
G
Occhipinti
P
P
Picchini
G
G
Sartori
M
M
D000328:Adult; D016009:Chi-Square Distribution; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction; D012189:Retrospective Studies
D007370:Interferon Type I; D011994:Recombinant Proteins
La risposta sostenuta nella epatite cronica C trattata con interferone.