Structure and antimicrobial activity of diterpenes from the roots of Plectranthus hereroensis.
Two abietane-type diterpenoids have been isolated from the roots of Plectranthus hereroensis (Labiatae), one being the already known horminone [1] and the other a new substance, 7 alpha,12-dihydroxy-17(15-->16)-abeo-abieta-8,12,16-triene-11 ,14-dione [2], whose structure was established by spectroscopic means. Compounds 1 and 2 showed antimicrobial activity against Staphylococcus aureus, Vibrio cholerae, Candida albicans, and Pseudomonas aeruginosa.
Batista
O
O
Faculdade de Farmácia de Lisboa, Universidade de Lisboa, Portugal.
Duarte
A
A
Nascimento
J
J
Simões
M F
MF
de la Torre
M C
MC
Rodríguez
B
B
D045784:Abietanes; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001681:Biological Assay; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
C089566:7,12-dihydroxy-17(15-16)-abieta-8,12,16-triene-11,14-dione; D045784:Abietanes; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010616:Phenanthrenes; C045490:horminone