n-3 fatty acid deficiency increases brain protein synthesis in the free-moving adult rat.
The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control animals. Biochemical analysis confirmed the increase in overall rate of protein synthesis in brain as a whole.
Giaume
M
M
CERMEP, Hôpital Neurologique, Lyon, France.
Gay
N
N
Baubet
V
V
Gharib
A
A
Durand
G
G
Bobillier
P
P
Sarda
N
N
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D003677:Deficiency Diseases / Q000378:metabolism / Q000503:physiopathology; D015525:Fatty Acids, Omega-3 / Q000378:metabolism* / Q000502:physiology; D005260:Female; D008715:Methionine / Q000378:metabolism; D009068:Movement / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013462:Sulfur Radioisotopes
D015525:Fatty Acids, Omega-3; D011506:Proteins; D013462:Sulfur Radioisotopes; D008715:Methionine