The effects of subcutaneous administration of arginine-8-vasopressin on the electroencephalogram of conscious rats are mediated by peripheral vasopressin V1 receptors.
The effects of subcutaneous (s.c.) administration of arginine-8-vasopressin (AVP) were investigated on the electroencephalogram (EEG) of conscious rats. AVP (1 mcg/kg) had no effect on the EEG. However, AVP (5 and 10 mcg/kg) produced significant changes in the spectral power of the EEG in a manner that was consistent with increase in level of arousal. Analogs of AVP which are virtually devoid of vasopressin V1 receptor agonist activity, desglycinamide-9 arginine-8 vasopressin (10 mcg/kg, s.c.) and 1-deamino-8-D arginine-8 vasopressin (10 mcg/kg, s.c.), had no effect on the EEG. Pretreatment with 1-(beta-mercapto-beta,beta-cyclopentamethylene propionic acid)2(O-methyl)tyrosine arginine-8 vasopressin (10 mcg/kg), a vasopressin V1 receptor antagonist, abolished the effects of AVP (10 mcg/kg) on the EEG. As systemically administered AVP cannot cross the blood-brain barrier, the present results indicate that the effects of s.c. AVP on the EEG of conscious rats are mediated by peripheral vasopressin V1 receptors.
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A.F.R.C. Babraham Institute, Cambridge, UK.
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D003243:Consciousness; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004594:Electrophysiology; D005260:Female; D005583:Fourier Analysis; D007279:Injections, Subcutaneous; D051381:Rats; D017208:Rats, Wistar; D017483:Receptors, Vasopressin / Q000819:agonists / Q000187:drug effects* / Q000502:physiology*
D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; C015119:argipressin, des-GlyNH2(9)-; D003894:Deamino Arginine Vasopressin