title: [Adenosine triphosphate for supraventricular tachycardia in newborns and suckling infants].
abstract: A previously healthy and normally developing 12-day-old female suddenly became restless and developed cold sweats, tachypnoea and tachycardia (300 beats/min). Neither electrocardiogram nor echocardiogram showed evidence of any cardiac defect. Carotid sinus massage and other vagus-stimulating manoeuvres, undertaken because paroxysmal supraventricular tachycardia (PSVT) was suspected, were unsuccessful. Before rapid digitalization, adenosine triphosphate was administered (0.1 mg/kg intravenously). Sinus rhythm was restored within about 60 s. Despite further treatment with digoxin and verapamil (4 mg/kg.d), further episodes of PSVT occurred, each again responding to ATP (0.1 to 0.3 mg/kg). There were no side effects. After 24-hour Holter ECG monitoring had revealed Wolff-Parkinson-White syndrome as cause of the PSVT, propafenone was administered (15 mg/kg daily) and has prevented further recurrence of the tachycardia.
authors.affiliation: Universitäts-Kinderklinik, Fakultät für klinische Medizin Mannheim, Universität Heidelberg.
authors.forename: N A
authors.initials: NA
authors.lastname: Haas
authors.forename: C
authors.initials: C
authors.lastname: Pufahl
authors.forename: S A
authors.initials: SA
authors.lastname: König
authors.forename: P
authors.initials: P
authors.lastname: Gessler
authors.forename: M
authors.initials: M
authors.lastname: Teufel
mesh_terms: D000255:Adenosine Triphosphate / Q000627:therapeutic use*; D004077:Digoxin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004452:Echocardiography; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011405:Propafenone / Q000627:therapeutic use; D013617:Tachycardia, Supraventricular / Q000188:drug therapy* / Q000209:etiology; D014700:Verapamil / Q000627:therapeutic use; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D011405:Propafenone; D004077:Digoxin; D000255:Adenosine Triphosphate; D014700:Verapamil
vernacular_title: Adenosintriphosphate bei supraventrikulären Tachykardien im Neugeborenen- und Säuglingsalter.