Lack of activity of ketorolac in hot-plate test and serotonin binding capacity of brain membranes in rats.
An increasing number of observations indicate that prostaglandin synthesis inhibition is not a satisfactory explanation for the antinociceptive activity of the non-steroidal anti-inflammatory drugs. In the hot-plate test performed 1 or 2 h after ketorolac at 40, 70 and 100 mg/kg i.p., the drug does not display any significant antinociceptive activity. Nor, at the two higher doses used, does it affect the cortical and pontine serotonin binding capacity of rat brain membranes 2 h after treatment. The data suggest that this lack of anti-nociceptive activity in the hot-plate test is associated with the drug's inability to affect the central serotoninergic system.
Vitale
G
G
Clinical Pharmacology Department, University of Modena, Italy.
Sandrini
M
M
Pini
L A
LA
D000700:Analgesics / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D006358:Hot Temperature; D007274:Injections, Intraperitoneal; D020910:Ketorolac; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D000700:Analgesics; D011985:Receptors, Serotonin; D012701:Serotonin; D014046:Tolmetin; D020910:Ketorolac