Additive effect of tolC and rfa mutations on the hydrophobic barrier of the outer membrane of Escherichia coli K-12.
Studies using tolC mutant derivatives of deep rough (rfa) mutants indicate that tolC and rfa mutations have an additive effect with respect to their sensitivity to hydrophobic agents, suggesting that they are not acting through a mutual mechanism to alter the permeability of the outer membrane.
Fralick
J A
JA
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock 79430.
Burns-Keliher
L L
LL
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001692:Biological Transport; D002240:Carbohydrate Sequence; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000235:genetics / Q000502:physiology*; D003840:Deoxycholic Acid / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D029968:Escherichia coli Proteins; D007612:Kanamycin / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000096:biosynthesis*; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D009154:Mutation; D009675:Novobiocin / Q000494:pharmacology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology
D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D008070:Lipopolysaccharides; D026901:Membrane Transport Proteins; C073126:tolC protein, E coli; D003840:Deoxycholic Acid; D009675:Novobiocin; D012967:Sodium Dodecyl Sulfate; D007612:Kanamycin