title: Safe administration of iron dextran to a patient who reacted to the test dose.
abstract: Parenteral iron therapy is infrequently required but generally well tolerated. We present a case in which intravenous iron dextran was successfully given to a patient who had an anaphylactoid reaction to the test dose. After pretreatment with methylprednisolone, diphenhydramine, ephedrine, and dextran 1, 2 g of iron dextran were safely given over several days; pretreatment was administered only on day 1. In the rare cases in which an anaphylactic agent must be given to a patient with a history of a life-threatening reaction to the agent, pretreatment along with slow escalation of dose may allow safe administration of the offending drug.
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205.
authors.forename: M S
authors.initials: MS
authors.lastname: Monaghan
authors.forename: G
authors.initials: G
authors.lastname: Glasco
authors.forename: G
authors.initials: G
authors.lastname: St John
authors.forename: R W
authors.initials: RW
authors.lastname: Bradsher
authors.forename: K M
authors.initials: KM
authors.lastname: Olsen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000707:Anaphylaxis / Q000139:chemically induced*; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy; D003888:Desensitization, Immunologic / Q000379:methods*; D006801:Humans; D007505:Iron-Dextran Complex / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
chemical_list: D007505:Iron-Dextran Complex