title: Epidemiology and clinical manifestations of visceral and cutaneous leishmaniasis in Baringo District, Rift Valley, Kenya. A literature review.
abstract: Visceral leishmaniasis (VL), caused by Leishmania donovani, is endemic in Baringo District, Kenya. The disease has a focal distribution in the dry, hot areas below 1500 metres. Infections may be characterized as follows: 1) asymptomatic, 2) subclinical and self-limiting (not medically identifiable), and 3) clinically manifest disease (that is medically identifiable). Half of the reported VL patients are between 5 and 14 years of age and 66% of them are males. The reasons for the focal distribution and for the age and sex preference are discussed. Phlebotomus martini is the vector of the parasite, and man is the only known reservoir. Cutaneous leishmaniasis (CL), due to Leishmania major, is rare in humans, but underreporting is likely. The vector, Phlebotomus duboscqui, is mainly found in animal burrows where it feeds on rodents which are frequently infected. A human case of a mixed L. donovani and L. major infected. A human case of a mixed L. donovani and L. major infection has been reported in this dual focus of VL and CL.
authors.affiliation: Unit of Infectious Diseases and Tropical Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: K U
authors.initials: KU
authors.lastname: Schaefer
authors.forename: J A
authors.initials: JA
authors.lastname: Kurtzhals
authors.forename: J A
authors.initials: JA
authors.lastname: Sherwood
authors.forename: J I
authors.initials: JI
authors.lastname: Githure
authors.forename: P A
authors.initials: PA
authors.lastname: Kager
authors.forename: A S
authors.initials: AS
authors.lastname: Muller
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D002980:Climate; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007630:Kenya / Q000453:epidemiology; D016773:Leishmaniasis, Cutaneous / Q000150:complications / Q000453:epidemiology*; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000453:epidemiology*; D008297:Male; D017678:Sex Distribution