Short communication: parathyroid hormone-related peptide does not stimulate phosphate placental transport.
It has been demonstrated that parathyroid hormone-related peptide (PTHrP) stimulates calcium (Ca) placental transport. Ca and inorganic phosphorous (P) metabolisms are intimately linked. Thus we have studied the influence of PTHrP on P placental transport in ewes. In our experimental paradigm, synthetic human PTHrP (1-86) fragment intravenously injected in six single chronically catheterized fetuses (3 x 1 micrograms/fetus/day, from day 129 to day 140 of gestation) had no significant effect upon P placental transport which was 131 +/- 6 and 129 +/- 9 mg/kg fetal weight/day in treated and control fetuses, respectively.
Barlet
J P
JP
INRA Clermont-Theix, France.
Davicco
M J
MJ
Rouffet
J
J
Coxam
V
V
Lefaivre
J
J
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000378:metabolism; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism*; D010758:Phosphorus / Q000097:blood / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012756:Sheep
D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D010455:Peptides; D010710:Phosphates; C068871:parathyroid hormone-related protein (1-86); D010758:Phosphorus; D002118:Calcium