title: Correlation of octanol-water partition coefficients with capacity factors measured by micellar electrokinetic chromatography.
abstract: Micellar electrokinetic chromatography (MEKC) was used to measure hydrophobicity of 18 aromatic compounds. The capacity factors, which are proportional to the micelle-water distribution coefficients, were closely correlated with the octanol-water partition coefficients. The addition of Brij 35 to the charged micelle was effective in improving the correlation because the surface charges of the micelle were shielded.
authors.affiliation: Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ishihama
authors.forename: Y
authors.initials: Y
authors.lastname: Oda
authors.forename: K
authors.initials: K
authors.lastname: Uchikawa
authors.forename: N
authors.initials: N
authors.lastname: Asakawa
mesh_terms: D002845:Chromatography; D004563:Electrochemistry; D008823:Micelles; D000442:Octanols / Q000737:chemistry*; D000077423:Polidocanol; D011092:Polyethylene Glycols; D012995:Solubility; D014014:Tissue Adhesives; D014867:Water / Q000737:chemistry*
chemical_list: D008823:Micelles; D000442:Octanols; D014014:Tissue Adhesives; D014867:Water; D000077423:Polidocanol; D011092:Polyethylene Glycols