The Ikaros gene is required for the development of all lymphoid lineages.
The Ikaros gene encodes a family of early hematopoietic- and lymphocyte-restricted transcription factors. Mice homozygous for a germline mutation in the Ikaros DNA-binding domain lack not only T and B lymphocytes and natural killer cells but also their earliest defined progenitors. In contrast, the erythroid and myeloid lineages were intact in these mutant mice. We propose that Ikaros promotes differentiation of pluripotential hematopoietic stem cell(s) into the lymphocyte pathways. In the absence of a functional Ikaros gene, these stem cells are exclusively diverted into the erythroid and myeloid lineages.
Georgopoulos
K
K
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown 02129.
Bigby
M
M
Wang
J H
JH
Molnar
A
A
Wu
P
P
Winandy
S
S
Sharpe
A
A
D000818:Animals; D001483:Base Sequence; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins; D000078404:Epidermal Cells; D018507:Gene Expression Regulation, Developmental; D018390:Gene Targeting; D018095:Germ-Line Mutation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051740:Ikaros Transcription Factor; D007694:Killer Cells, Natural / Q000166:cytology; D008198:Lymph Nodes; D008214:Lymphocytes / Q000166:cytology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D011485:Protein Binding; D012333:RNA, Messenger / Q000032:analysis; D013154:Spleen / Q000166:cytology / Q000473:pathology; D013950:Thymus Gland / Q000166:cytology; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C497238:Zfpn1a1 protein, mouse; D051740:Ikaros Transcription Factor; D004247:DNA