title: Analysis of auditory brain stem response with lidocaine injection into the cerebrospinal fluid in rats.
abstract: Auditory brain stem response (ABR) was recorded in 10 rats with total spinal anesthesia induced by injection of 2% lidocaine hydrochloride into the subarachnoid space through the skull. The ABR disappeared immediately (within 4 minutes) after the injection of 13.3 to 40.0 mg/kg lidocaine. The disappearance started with the later waves of the ABR. After cessation of the injection, the ABR reappeared and recovered progressively from wave I to wave IV. The effect of lidocaine on the ABR was reversible and extended in the acoustic nerve to the midbrain.
authors.affiliation: Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Kaga
authors.forename: T
authors.initials: T
authors.lastname: Tsuzuku
authors.forename: A
authors.initials: A
authors.lastname: Uno
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000187:drug effects*; D002555:Cerebrospinal Fluid / Q000187:drug effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013346:Subarachnoid Space / Q000187:drug effects; D000159:Vestibulocochlear Nerve / Q000187:drug effects
chemical_list: D008012:Lidocaine