DNA repair. DNA surveillance defect in cancer cells.
A defect in a protein involved in DNA-mismatch correction accounts for a common type of hereditary colon cancer, adding to the evidence that DNA repair is central to counteracting the transformation of human cells.
Lindahl
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Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, UK.
D000251:Adenosine Triphosphatases; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins; D006801:Humans; D008954:Models, Biological; D051719:MutS DNA Mismatch-Binding Protein; D009154:Mutation
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D000251:Adenosine Triphosphatases; D051719:MutS DNA Mismatch-Binding Protein; C497175:MutS protein, E coli