title: The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein.
abstract: We report the entire sequence of a 26.4 kb segment of chromosome XI of Saccharomyces cerevisiae. Identification of the known loci URA1, TRP3 and SAC1 revealed a translocation compared to the genetic map. Additionally, six unknown open reading frames have been identified. One of them is similar to catabolic threonine dehydratases. Another one contains characteristic features of membrane transporters. A third one is homologous in half of its length to the prokaryotic hydantoinase HyuA and in the other half to hydatoinase HyuB. A fourth one is homologous to the mammalian phospholipase A2-activating protein. A fifth one, finally, is homologous to the hypothetical open reading frame YCR007C of chromosome III. The sequence has been deposited in the EMBL data library under Accession Number X75951.
authors.affiliation: Foundation for Research and Technology-HELLAS, Institute of Molecular Biology and Biotechnology, Crete, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Tzermia
authors.forename: O
authors.initials: O
authors.lastname: Horaitis
authors.forename: D
authors.initials: D
authors.lastname: Alexandraki
mesh_terms: D000581:Amidohydrolases / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D015825:Chromosomes, Fungal / Q000737:chemistry; D016681:Genome, Fungal; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013913:Threonine Dehydratase / Q000235:genetics*
chemical_list: D011506:Proteins; C055324:phospholipase A2-activating protein; D000581:Amidohydrolases; C020047:dihydropyrimidinase; D013913:Threonine Dehydratase