High-level multilineage engraftment of human cord blood cells in SCID mice.
Cord blood is increasingly used as an alternative to bone marrow transplantation in pediatric patients. Therefore, to study cord blood-derived hematopoiesis in vivo we are developing a xenogeneic transplantation model using immunodeficient SCID mice.
Vormoor
J
J
Hospital for Sick Children, Toronto, Ontario, Canada.
Lapidot
T
T
Pflumio
F
F
Risdon
G
G
Patterson
B
B
Broxmeyer
H E
HE
Dick
J E
JE
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D003114:Colony-Forming Units Assay; D005312:Fetal Blood / Q000166:cytology*; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D016513:Mice, SCID; D011828:Radiation Chimera; D016511:Severe Combined Immunodeficiency / Q000628:therapy*; D014183:Transplantation, Heterologous