In vitro effects of nifedipine on human red cell metabolism and blood coagulation.
In the present investigation, the effects of nifedipine on red cell deformability, intra-erythrocytic calcium and ATP as well as clotting time, prothrombin time (PT) and activated partial thromboplastin time (APTT) were determined in blood obtained from normal healthy individuals. Results obtained from this study showed that the addition of nifedipine (a membrane-active agent which inhibits Ca(2+)-Mg2+ ATPase) increased the deformability of these RBCs; this increase was statistically significant at p < 0.0001. The increase in deformability is assumed to be related to increases in intra-erythrocytic Ca2+ and ATP levels which are brought about by the action of this drug. However, nifedipine produced no changes in the clotting time, PT or APTT.
Meky
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Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D004907:Erythrocyte Deformability / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D014914:Whole Blood Coagulation Time
D009543:Nifedipine; D002118:Calcium