Rabbit gastric lipase in biocatalytic resolution of 2-hydroxyalkyldiphenylphosphines.
Kinetic resolution of 2-hydroxyalkyldiphenylphosphines 4 by acylation with isopropenyl acetate was carried out under rabbit gastric lipase (RGL) catalysis to give optically active 4 and the corresponding acetate, the enantioselectivity factors E ranging from 10 to 20. 1-(2-Naphthyl)ethanol and 2-[N-(ethoxycarbonyl)amino]1-butanol 7 were also resolved.
Kagan
H B
HB
Laboratoire de Synthèse Asymétrique, URA CNRS 1497, Université Paris-Sud, Orsay, France.
Tahar
M
M
Fiaud
J C
JC
D000215:Acylation; D000818:Animals; D066298:In Vitro Techniques; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D011817:Rabbits; D013237:Stereoisomerism; D013270:Stomach / Q000201:enzymology
D010720:Phosphines; D008049:Lipase