title: An algorithm for identifying regions of a DNA sequence that satisfy a content requirement.
abstract: We present a dynamic programming algorithm for identifying regions of a DNA sequence that meet a user-specified compositional requirement. Applications of the algorithm include finding C + G-rich regions, locating TA + CG-deficient regions, identifying CpG islands, and finding regions rich in periodical three-base patterns. The algorithm has an advantage over the simple window method in that the algorithm shows the exact location of each identified region. The algorithm has been implemented as a portable C program called LCP (Local Content Program). LCP is extremely efficient in computer time and memory; it instantly locates all regions of a long DNA sequence meeting a given requirement. The LCP program was used to analyze the rabbit alpha-like globin gene cluster sequence.
authors.affiliation: Department of Computer Science, Michigan Technological University, Houghton 49931-1295.
authors.forename: X
authors.initials: X
authors.lastname: Huang
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping; D008432:Mathematical Computing; D017422:Sequence Analysis, DNA; D012984:Software; D014584:User-Computer Interface