title: Effects of the antiallergic drug azelastine hydrochloride on proliferative responses of lymphocytes to food antigens in patients with food-sensitive atopic dermatitis.
abstract: We previously reported that the proliferative responses of peripheral blood mononuclear cells (PBMCs) to ovalbumin (OA) or bovine serum albumin (BSA) in children with atopic dermatitis (AD) who are sensitive to hen's egg or cow's milk were significantly higher than those of healthy children and hen's egg- or cow's milk-sensitive children with immediate symptoms. Azelastine hydrochloride is an antiallergic drug used in the treatment of rhinitis and asthma. In this study, we have shown that the proliferative responses of PBMCs to OA are concentration-dependently inhibited by azelastine in patients with AD. Moreover, the inhibition resulted from the effects of azelastine on T-cells.
authors.affiliation: Department of Pediatrics, Gifu University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Agata
authors.forename: O
authors.initials: O
authors.lastname: Fukutomi
authors.forename: T
authors.initials: T
authors.lastname: Kameyama
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Shimozawa
authors.forename: S
authors.initials: S
authors.lastname: Tomatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Nakashima
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: A
authors.initials: A
authors.lastname: Yamagishi
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002645:Chickens / Q000276:immunology; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology; D005512:Food Hypersensitivity / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation / Q000187:drug effects*; D016269:Milk Hypersensitivity / Q000188:drug therapy / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D010793:Phthalazines / Q000494:pharmacology*
chemical_list: D010793:Phthalazines; D010047:Ovalbumin; C020976:azelastine