Fluvoxamine-associated sexual dysfunction.
OBJECTIVE
To report two cases of sexual dysfunction induced by fluvoxamine, a selective serotonin reuptake inhibitor (SSRI).


METHODS
University teaching hospital.


METHODS
Two depressed patients who developed ejaculation and orgasmic difficulties after initiation of fluvoxamine therapy.


CONCLUSIONS
The literature concerning sexual dysfunction with serotonergic antidepressants is reviewed, and speculated mechanisms for this untoward effect are discussed.


CONCLUSIONS
Sexual dysfunction associated with antidepressant drugs, including SSRIs, may be underreported. This troublesome adverse effect may significantly affect patient comfort and compliance. Careful evaluation of sexual function is warranted, prior to and during drug treatment, especially as more serotonergic antidepressant agents become available.
Dorevitch
A
A
Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.
Davis
H
H
D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy; D007172:Erectile Dysfunction / Q000139:chemically induced; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects*; D006785:Hospitals, University; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced
D016666:Fluvoxamine