title: [Study on intratumor administration of lentinan--primary changes in cancerous tissues].
abstract: Lentinan was administered for gastric cancer in order to determine what type of changes would occur as a consequence. In an experimental study, the intraperitoneal administration of lentinan on cancerous tissues caused a marked development of reticular fibers, along with an enhanced interstitial response. Findings which support the relationship between a marked development of reticular fibers and an anti-tumor effect, were also obtained. Furthermore, lentinan was administered for human gastric cancer to evaluate whether or not an increase in interstitial response would be observed. As a result, reticular fibers developed in tumor sites with a resultant fragmentation of cancer cell nests. Many T lymphocytes infiltrated cancer sites where the lentinan was administered. These findings suggest that the intratumor administration of lentinan enhanced an interstitial response and also activated an anti-tumor immune response in the human gastric cancer tissues.
authors.affiliation: Dept. of Surgery, Tokyo Women's Medical College Daini Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Katsube
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Hirai
authors.forename: S
authors.initials: S
authors.lastname: Wakasugi
authors.forename: H
authors.initials: H
authors.lastname: Yagawa
authors.forename: T
authors.initials: T
authors.lastname: Kajiwara
authors.forename: T
authors.initials: T
authors.lastname: Suga
authors.forename: J
authors.initials: J
authors.lastname: Hamuro
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D007274:Injections, Intraperitoneal; D007912:Lentinan / Q000008:administration & dosage*; D051379:Mice; D009368:Neoplasm Transplantation; D016622:Silver Staining; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D007912:Lentinan