title: Effects of hypoxia on platelet activation in pilots.
abstract: In order to evaluate the effect of hypoxia on platelet activation, 53 pilots were chosen for this study. Thirty were selected as the hypoxic group, and the other 23 as a control group. The plasma concentration of thromboxane B2(TXB2), 6-keto-prostaglandin f1 alpha (6-keto-PGF1 alpha), beta-thrombo-globulin (BTG) and platelet factor 4 (PF4) were measured during altitude chamber tests. After staying at 5000 m for 15 min, the plasma level of TXB2, BTG and PF4 increased significantly over pre-test levels (p < 0.01), but 6-keto-PGF1 alpha had no distinct change (p > 0.05). These changes indicate that moderate acute hypoxia causes increases in platelet activation, but has less effects on the endothelial cells.
authors.affiliation: Department of Nuclear Medicine, Space Central Hospital, Beijing, P. R. China.
authors.forename: D
authors.initials: D
authors.lastname: Shen
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D000337:Aerospace Medicine; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D008297:Male; D008889:Military Personnel; D015539:Platelet Activation; D010978:Platelet Factor 4 / Q000032:analysis; D013929:Thromboxane B2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha