[Successful treatment of panarteritis nodosa with low-dose methotrexate therapy].
We report on a 45-year-old male patient who presented a classic polyarteritis nodosa (PAN). The clinical course extended over 7 years. In spite of 2 years immunosuppressive therapy with azathioprine and methylprednisolone the course was progressive. Low-dose methotrexate therapy was the only treatment that controlled the disease, leading to rapid clinical and histopathological remission. In low concentrations methotrexate acts as an IL-1 inhibitor, and it obviously suppresses the pathogenetic mechanism of PAN.
Brody
M
M
Dermatologische Klinik und Poliklinik, Rheinische Friedrich-Wilhelms-Universität Bonn.
Böhm
I
I
Biwer
E
E
Bauer
R
R
D001158:Arteries / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D007871:Leg Ulcer / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D018655:Lymphocyte Count / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000098:blood supply; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007375:Interleukin-1; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D008727:Methotrexate
Erfolgreiche Behandlung einer Panarteriitis nodosa mit Methotrexat Low-dose-Therapie.