title: Optic neuritis. Differential losses of luminance and chromatic function near a scotoma.
abstract: Visual sensitivity to achromatic and chromatic stimulus flashes was determined at sites just inside, on the boundary and just outside scotomata in 11 patients with recovered optic neuritis. The colour of the flashes and the size of the steady background on which they appeared were such that detection was more likely to be mediated by either the large-diameter, magnocellular fibres or the small-diameter, parvocellular fibres of the anterior visual pathway. The spacing of the test sites ranged from 0.5 degrees to 4 degrees visual angle, depending on the shape and location of the scotomata. The greatest differences in sensitivity were between sites just inside and just outside the scotoma and in response to achromatic stimuli more likely to involve the magnocellular fibres. This effect may be due to the size of magnocellular fibres or to their relatively smaller numbers.
authors.affiliation: Department of Postgraduate Medicine, Keele University, Staffordshire, UK.
authors.forename: M L
authors.initials: ML
authors.lastname: Phillips
authors.forename: D H
authors.initials: DH
authors.lastname: Foster
authors.forename: W P
authors.initials: WP
authors.lastname: Honan
authors.forename: G K
authors.initials: GK
authors.lastname: Edgar
authors.forename: J R
authors.initials: JR
authors.lastname: Heron
mesh_terms: D000328:Adult; D003118:Color Perception; D003711:Demyelinating Diseases / Q000503:physiopathology; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D009900:Optic Nerve / Q000503:physiopathology; D009902:Optic Neuritis / Q000503:physiopathology*; D012607:Scotoma / Q000503:physiopathology*; D012684:Sensory Thresholds; D014793:Visual Cortex / Q000503:physiopathology; D014795:Visual Pathways