title: Simplification of superovulation induction by using polyvinylpyrrolidone as a solvent for FSH in rabbits.
abstract: With a view to simplify the method of inducing superovulation in rabbits, polyvinylpyrrolidone (PVP) was used as a solvent for follicle-stimulating hormone (FSH). As a result, it became clear that more than the equivalent number of ovulation points and fertilized ova that are obtainable by the conventional six injections of FSH were able to be obtained by only a single injection of FSH-PVP preparation. Inflammation or swelling of the tissue was not observed in the injection site or its vicinity. The results seem to enable simplification of superovulation induction by using PVP as a vehicle for FSH in rabbits. This finding could reduce injection distress to the animals and labor of the operator.
authors.affiliation: Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kanayama
authors.forename: T
authors.initials: T
authors.lastname: Sankai
authors.forename: K
authors.initials: K
authors.lastname: Nariai
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: Y
authors.initials: Y
authors.lastname: Sakuma
mesh_terms: D000818:Animals; D005260:Female; D005306:Fertilization; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000494:pharmacology; D010062:Ovulation Induction / Q000662:veterinary*; D011205:Povidone; D011817:Rabbits; D012965:Sodium Chloride; D012997:Solvents; D013480:Superovulation / Q000187:drug effects*
chemical_list: D012997:Solvents; D012965:Sodium Chloride; D005640:Follicle Stimulating Hormone; D011205:Povidone