The mechanism of V(D)J recombination: site-specificity, reaction fidelity and immunologic diversity.
Site-specific recombination reactions in higher eukaryotes are uncommon, perhaps because of the potential genomic instability that they may create. We focus this review on the issues of site-specificity, reaction fidelity and immunologic diversity in the V(D)J recombination reaction.
Lieber
M R
MR
Department of Pathology, Stanford University School of Medicine, CA 94305-5324.
Chang
C P
CP
Gallo
M
M
Gauss
G
G
Gerstein
R
R
Islas
A
A
D000818:Animals; D000916:Antibody Diversity / Q000235:genetics; D001483:Base Sequence; D015321:Gene Rearrangement / Q000235:genetics* / Q000276:immunology; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D007136:Immunoglobulins / Q000235:genetics*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011946:Receptors, Antigen / Q000235:genetics* / Q000276:immunology; D011995:Recombination, Genetic
D007136:Immunoglobulins; D011946:Receptors, Antigen