title: Bronchoalveolar lavage and its role in diagnosing cobalt lung disease.
abstract: The bronchoalveolar lavage (BAL) of two groups of hard metal workers (11 subjects) were examined and compared with BALs of 14 unexposed individuals as controls. The first group of workers included five asymptomatic subjects (2 females and 3 males) with normal lung function tests and chest X-rays. All the workers had been exposed daily to hard metal dust for 5 years before fiberoptic bronchoscopy. The second group of workers included six individuals (1 female and 5 males) with cobalt lung disease at biopsy. The BAL's cytology at the deep lung level is in agreement with a possible immunologic pathogenesis of the lung disease, similar to hypersensitivity pneumonitis (lymphocytosis with helper-suppressor ratio reduction). In order to identify diagnostic key-parameters, the data presented here are compared with data reported in literature for workers with a history of hard metal or cobalt (alone) exposure. Although the BAL can be useful, for a better definition of the reaction at the deep lung level, it seems insufficient per se for the diagnosis of hard metal lung disease.
authors.affiliation: Department of Pneumology, Ospedali Riuniti of Bergamo, Largo Barozzi, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Michetti
authors.forename: G
authors.initials: G
authors.lastname: Mosconi
authors.forename: R
authors.initials: R
authors.lastname: Zanelli
authors.forename: M
authors.initials: M
authors.lastname: Migliori
authors.forename: G
authors.initials: G
authors.lastname: Gaffuri
authors.forename: R
authors.initials: R
authors.lastname: Villa
authors.forename: L
authors.initials: L
authors.lastname: Michetti
mesh_terms: D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003035:Cobalt / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000473:pathology*; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D003035:Cobalt