Positive nitrogen balance after intraperitoneal administration of amino acids in 3 patients.
OBJECTIVE
To determine whether intraperitoneal (IP) administration of amino acids improves nitrogen balance during continuous ambulatory peritoneal dialysis (CAPD).


METHODS
Nitrogen balance studies of CAPD patients comparing periods of peritoneal dialysis using dialysate with nitrogen added from a commercial amino acid solution, versus standard dialysate.


METHODS
Clinical research center in a tertiary facility.


METHODS
Patients on CAPD who volunteered.


METHODS
One 4-day balance period was carried out with conventional dialysate and one 4-day period with conventional dialysate to which amino acids were added. The study periods were separated by a 3-day washout period.


METHODS
Nitrogen accumulation or loss during each period.


RESULTS
The mean (SD) daily control period balances (grams per day) were 0.2, 1.9, and -3.4; during the amino acid period the balances were 5.4, 2.7, -0.7. The mean daily control effluent dialysate volumes (milliliters) were 11,350 +/- 443, 10,052 +/- 449, and 10,165 +/- 154; during the amino acid period the volumes were 10,345 +/- 50, 12,325 +/- 1021, and 10,220 +/- 655.


CONCLUSIONS
The IP addition of amino acids diminishes the amount of nitrogen lost from dialysate while maintaining effluent dialysate volume. Nitrogen balances improved in all 3 patients during the period with IP amino acids, compared to control.
Rubin
J
J
University of Mississippi, Medical Center, Jackson.
Garner
T
T
D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage*; D015314:Dialysis Solutions; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism*; D010531:Peritoneal Dialysis, Continuous Ambulatory
D000596:Amino Acids; D015314:Dialysis Solutions; D009584:Nitrogen