[Pharmacological action of 101-B hair regeneration extract on skin and hair in experimental animals].
Pharmacological action of 101-B hair regeneration extract (101-B) on skin and hair was studied in experimental animals. The results were as follows: (1) In normal rats, guinea pigs and rabbits the weight of regrown hairs in shaved area in 101-B group was significantly heavier than that in alcohol group. (2) Hair loss induced by oral administration of thallium carbonate 2 mg/kg every other day for 10 times was obviously prevented by topical treatment of 101-B. (3) Itching threshold to histamine or papain in guinea pig was elevated after using of 101-B topically. (4) The diameter of skin ulcer caused by intradermal injection of adriamycin in rats was diminished in 101-B group. (5) Observation in skin microcirculation in mice indicated that both normal skin microcirculation and disturbed microcirculation induced by endotoxin were improved with administration of 101-B. Above experimental results provided preliminary evidence for clinical use of 101-B.
Qian
B C
BC
Inst. of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou.
Chen
J
J
Xu
H J
HJ
D000505:Alopecia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D004317:Doxorubicin; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000494:pharmacology*; D004431:Ear, External / Q000098:blood supply; D005260:Female; D006168:Guinea Pigs; D006197:Hair / Q000254:growth & development*; D006203:Hair Preparations / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008833:Microcirculation / Q000187:drug effects; D011537:Pruritus / Q000139:chemically induced; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012883:Skin Ulcer / Q000517:prevention & control; D013793:Thallium
D004365:Drugs, Chinese Herbal; D006203:Hair Preparations; D004317:Doxorubicin; D013793:Thallium