The pharmacokinetics of fluconazole after a single intravenous dose in AIDS patients.
The pharmacokinetics of fluconazole after a single 100 mg i.v. dose were studied in 10 healthy subjects (5 M; 5 F) and 10 HIV-positive patients (8 M; 2 F). The mean value of plasma clearance was 25% lower in the patient groups (17 +/- 6 (s.d.) vs 23 +/- 4 ml min-1; 95% CI of difference -11 to -0.7; P < 0.05). This difference may have been related to slightly reduced kidney function in the patient group (mean creatinine clearance -18%) but is unlikely to be clinically significant. Therefore, no adjustment of the dose of intravenously administered fluconazole appears to be necessary in AIDS patients without clinical signs of enteropathy.
Yeates
R A
RA
Pfizer-Mack Ltd, Illertissen, Germany.
Ruhnke
M
M
Pfaff
G
G
Hartmann
A
A
Trautmann
M
M
Sarnow
E
E
D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism*; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000378:metabolism; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate
D015725:Fluconazole; D003404:Creatinine