title: Effect of site-specific modification on restriction endonucleases and DNA modification methyltransferases.
abstract: Restriction endonucleases have site-specific interactions with DNA that can often be inhibited by site-specific DNA methylation and other site-specific DNA modifications. However, such inhibition cannot generally be predicted. The empirically acquired data on these effects are tabulated for over 320 restriction endonucleases. In addition, a table of known site-specific DNA modification methyltransferases and their specificities is presented along with EMBL database accession numbers for cloned genes.
authors.affiliation: California Institute of Biological Research, La Jolla 92037.
authors.forename: M
authors.initials: M
authors.lastname: McClelland
authors.forename: M
authors.initials: M
authors.lastname: Nelson
authors.forename: E
authors.initials: E
authors.lastname: Raschke
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology; D001483:Base Sequence; D004247:DNA / Q000378:metabolism; D015254:DNA Modification Methylases / Q000235:genetics* / Q000378:metabolism; D004262:DNA Restriction Enzymes / Q000235:genetics* / Q000378:metabolism; D006868:Hydrolysis; D007700:Kinetics; D008745:Methylation; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides
chemical_list: D009838:Oligodeoxyribonucleotides; D004247:DNA; D015254:DNA Modification Methylases; D004262:DNA Restriction Enzymes