title: [Hyperstimulation for in vitro fertilization with the "step-down" technique. Preliminary results from a prospective randomized study with and without LHRH agonists].
abstract: Twenty six normo-ovulatory patients < 38 years with tubal or idiopathic infertility and normal sperm were treated for IVF by FSH +/- hMG and randomized into four groups: with and without LHRH agonist, "step-up" or "step-down" stimulation. In the step down protocol, after 4 days with 4 amps plasmatic FSH reached its top level, then decreased. Despite reduction to only two amps, estradiol continued to increase in all the 5 women without agonist, whereas 3/7 with the long protocol were considered as low responders and stopped. The fertilization/cleavage rate was 69.2% in step-down and 45.7% in step-up (p < 0.04) with the short protocol, and respectively 65.6% and 41.9% (p < 0.03) with the long one. The pregnancy rate was equivalent in all groups.
authors.affiliation: Service de gynécologie-obstétrique, Hôpital Tenon, Paris.
authors.forename: J M
authors.initials: JM
authors.lastname: Antoine
authors.forename: J
authors.initials: J
authors.lastname: Salat-Baroux
authors.forename: S
authors.initials: S
authors.lastname: Alvarez
authors.forename: D
authors.initials: D
authors.lastname: Cornet
authors.forename: C
authors.initials: C
authors.lastname: Firmin
authors.forename: J
authors.initials: J
authors.lastname: Mandelbaum
authors.forename: M
authors.initials: M
authors.lastname: Plachot
mesh_terms: D000328:Adult; D002985:Clinical Protocols; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies
chemical_list: D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D005640:Follicle Stimulating Hormone
vernacular_title: Hyperstimulation en vue de FIV selon la technique du "step-down". Résultats préliminaires d'une étude prospective randomisée avec ou sans agonistes de la LHRH.