Lifespan of immunosuppressed NMRI-mice is increased by deprenyl.
Immunosuppressed NMRI-mice (nu/nu) were raised and kept under germ-reduced conditions and fed with a germ-reduced diet (14 animals = controls). For another 14 mice 4 mg of selegiline were admixed to 10 kg of the diet. The 50% survival rate of the latter group was 160% from birth or 220% from the beginning of the study. The survival rate in weeks finally reached 350%, and the area under the curve 250%. The last mouse in the control group died at the age of 5 months, 2.5 months after the study was started; the last mouse in the selegiline group died at the age of 14.5 months, 1 year after the beginning of the study.
Freisleben
H J
HJ
Gustav-Embden-Zentrum der Biologischen Chemie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Federal Republic of Germany.
Lehr
F
F
Fuchs
J
J
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007108:Immune Tolerance; D008136:Longevity / Q000187:drug effects; D051379:Mice; D008819:Mice, Nude / Q000502:physiology; D012642:Selegiline / Q000494:pharmacology*; D016019:Survival Analysis
D012642:Selegiline