Cerebrodiene: a brain lipid isolated from sleep-deprived cats.
We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.
Lerner
R A
RA
Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037.
Siuzdak
G
G
Prospero-Garcia
O
O
Henriksen
S J
SJ
Boger
D L
DL
Cravatt
B F
BF
D000818:Animals; D001921:Brain / Q000502:physiology*; D002415:Cats; D002851:Chromatography, High Pressure Liquid; D005260:Female; D013058:Mass Spectrometry; D015394:Molecular Structure; D012892:Sleep Deprivation / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid / Q000737:chemistry / Q000302:isolation & purification
C089587:cerebrodiene; D013110:Sphingosine; C005682:safingol