Autonomic and behavioral responses of selectively bred hypercholinergic rats to oxotremorine and diisopropyl fluorophosphate.
The hypercholinergic Flinders Sensitive Line (FSL) rat was significantly more sensitive than the Flinders Resistant Line (FRL) rat to the biotelemetrically recorded hypothermic effects of oxotremorine, a direct-acting muscarinic agonist, and diisopropyl fluorophosphate (DFP), an anticholinesterase agent. The effects of these agents on heart rate and motor activity, also recorded biotelemetrically, indicate either small differences (DFP) or no significant effect (oxotremorine) between the lines. These findings confirm the dramatic differences in temperature responses to cholinergic compounds between FSL and FRL rats, for which they were selectively bred, but suggest that a general increase in the sensitivity of the FSL rats to all muscarinic-mediated responses may not occur.
Rezvani
A H
AH
Skipper Bowles Center for Alcohol Studies, Chapel Hill, NC 27599-7175.
Overstreet
D H
DH
Ejantkar
A
A
Gordon
C J
CJ
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D002940:Circadian Rhythm / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D007531:Isoflurophate / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010095:Oxotremorine / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D013045:Species Specificity
D007531:Isoflurophate; D010095:Oxotremorine