The MAG1* 3-methyladenine DNA glycosylase gene is closely linked to the SPT15 TATA-binding TFIID gene on chromosome V-R in Saccharomyces cerevisiae.
The MAG1 gene encodes a 3-methyladenine DNA glycoslyase, which is involved in DNA alkylation repair in Saccharomyces cerevisiae. The mag1 mutant is deficient in 3-methyladenine DNA glycosylase activity and shows enhanced sensitivity to several monofunctional alkylating agents. MAG1 is allelic to MMS5. This gene has been previously located on chromosome V by chromosomal hybridization. We present physical and genetic mapping data here showing that the MAG1 gene is located on chromosome V-R, proximal to and about 10 kilobase pairs away from the SPT15 gene coding for the yeast TATA-binding protein TFIID.
Xiao
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Department of Microbiology, University of Saskatchewan, Saskatoon, Canada.
Penugonde
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D002874:Chromosome Mapping; D015825:Chromosomes, Fungal; D045647:DNA Glycosylases; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000235:genetics*; D004926:Escherichia coli; D008040:Genetic Linkage; D009699:N-Glycosyl Hydrolases / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D035181:TATA-Box Binding Protein; D014157:Transcription Factors / Q000235:genetics*
D015342:DNA Probes; D004268:DNA-Binding Proteins; D035181:TATA-Box Binding Protein; D014157:Transcription Factors; C021565:3-methyladenine-DNA glycosylase; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases