Sustained-release dosage form of phenylpropanolamine hydrochloride (3). Application of factorial design.
In this study a 2(2) factorial design has been applied to the evaluation of dissolution characteristics of phenylpropranolamine hydrochloride (PPA.HCl) from tableted microcapsules. The kinetic model according to the Rosin-Rimmler-Sperling-Bennet-Weillbull (RRSBW) distribution was applied for the parametric representation of the dissolution curves. The effect of two factors; drug particle size and kind of disintegrating agent, on the dissolution rate of PPA.HCl were studied at two levels. The factorial design method proved to be useful for the examination of tableted microcapsules.
Sevgi
F
F
University of Ege, Faculty of Pharmacy, Pharmaceutical Technology Department, Izmir, Turkey.
Ozyazici
M
M
Güneri
T
T
D002214:Capsules; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005079:Excipients; D007700:Kinetics; D008956:Models, Chemical; D010316:Particle Size; D010665:Phenylpropanolamine / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013607:Tablets
D002214:Capsules; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D010665:Phenylpropanolamine