Mouse T lymphocytes that express a gamma delta T-cell antigen receptor contribute to resistance to Salmonella infection in vivo.
Mice depleted of lymphocytes expressing the alpha beta or the gamma delta T-cell receptor for antigen (TCR) by antibody treatment were infected orally with Salmonella enteritidis. In both groups of treated mice, the 50% lethal dose decreased, suggesting that both the alpha beta TCR+ and the gamma delta TCR+ subsets contribute to resistance to oral infection. These data provide further evidence for the contribution of gamma delta T cells in the response to bacterial infections.
Mixter
P F
PF
Department of Microbiology and Immunology, UCLA School of Medicine.
Camerini
V
V
Stone
B J
BJ
Miller
V L
VL
Kronenberg
M
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D007928:Lethal Dose 50; D008212:Lymphocyte Depletion; D051379:Mice; D008807:Mice, Inbred BALB C; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012477:Salmonella enteritidis / Q000472:pathogenicity; D016176:T-Lymphocyte Subsets / Q000502:physiology*
D000911:Antibodies, Monoclonal; D016692:Receptors, Antigen, T-Cell, gamma-delta