title: Perioperative thrombosis prophylaxis with low molecular weight heparins in elective hip surgery. Clinical and economic considerations.
abstract: A review and meta analysis of randomized prophylaxis studies in total hip arthroplasty (THA) surgery with the low molecular weight heparin (LMWH) compounds presently marketed in Europe. Thromboprophylaxis with recommended dosages of LMWH was significantly more effective than both placebo (no prophylaxis), dextran 70 and low-dose unfractionated heparin (UH) (5,000 IU thrice daily) in terms of protection against objectively diagnosed deep vein thrombosis (DVT), which is the main source of postoperative pulmonary embolism. The efficacy of LMWH was similar to that of adjusted-dose UH but only 2 studies have been conducted with this regimen so far. When combined with 0.5 mg dihydroergotamine (DHE), UH was as effective as LMWH, but DHE bears a definite risk of circulatory disturbances in the lower limbs. In all studies LMWH prophylaxis was safe under the clinical conditions. A cost-effectiveness analysis based on the reported efficacy and safety of LMWH in the European studies showed that, compared with no prophylaxis, dextran 70, and low-dose UH, LMWH prophylaxis used routinely in patients undergoing THA is more profitable for the health care system due to fewer expenses used on treatment of postoperative thromboembolic complications. LMWH therefore leads to better utilization of the economic resources.
authors.affiliation: Department of Orthopedics, Aalborg Hospital, Denmark.
authors.forename: L C
authors.initials: LC
authors.lastname: Borris
authors.forename: M R
authors.initials: MR
authors.lastname: Lassen
authors.forename: H P
authors.initials: HP
authors.lastname: Jensen
authors.forename: B S
authors.initials: BS
authors.lastname: Andersen
authors.forename: K A
authors.initials: KA
authors.lastname: Poulsen
mesh_terms: D003362:Cost-Benefit Analysis; D004087:Dihydroergotamine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005060:Europe; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D006622:Hip Prosthesis / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D006495:Heparin, Low-Molecular-Weight; D004087:Dihydroergotamine