[Bone marrow transplantation for a patient with ALL from her 75-year-old mother using cryopreserved bone marrow cells].
We report a 42-year-old woman with acute lymphoblastic leukemia who received allogeneic bone marrow transplantation (BMT) in the first remission from her 75-year-old, HLA-identical, MLC-non-reactive mother. Considering the difficulty to obtain a sufficient number of bone marrow cells from such an old donor, we harvested the cells (2.31 x 10(8)/kg) on day -37 and cryopreserved them until use. BMT was performed on June 3rd, 1993 after conditioning regimen with total body irradiation, high-dose AraC and cyclophosphamide. Graft-versus-host disease (GVHD) prophylaxisis was attempted by cyclosporin A and short-term methtrexate. Her hematopoietic recovery was favorable with no signs and symptoms of GVHD as far as day 218.
Uike
N
N
Department of Hematology, National Kyushu Cancer Center Hospital.
Suehiro
Y
Y
Takahira
H
H
Shimada
Y
Y
Nagatoshi
Y
Y
Ikuno
Y
Y
Okamura
J
J
Tasaka
H
H
Miyamura
T
T
Ishikura
H
H
D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D015925:Cryopreservation; D005260:Female; D006801:Humans; D009035:Mothers; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014019:Tissue Donors