title: Synthesis of doxorubicin-cyclodextrin conjugates.
abstract: Doxorubicin-gamma-cyclodextrin conjugates have been synthesized by the coupling of 14-bromodaunomycin with mono half-ester compounds linked to a 6-hydroxyl group of gamma-cyclodextrin. Release of drug from the conjugates in saline phosphate buffer solution and in vitro antitumor activity against L1210 leukemia cells were also investigated.
authors.affiliation: Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Kominato
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Yoshioka
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: H
authors.initials: H
authors.lastname: Tone
authors.forename: R
authors.initials: R
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D003505:Cyclodextrins / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers; D007939:Leukemia L1210 / Q000188:drug therapy
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D004317:Doxorubicin