title: Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease.
abstract: Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer's disease (AD). In order to investigate whether these changes are associated with compromised blood-brain transport mechanisms, hippocampal formation sections from AD and age-matched normal brains were immunolabelled with an antibody to the GLUT-1 glucose transporter protein. GLUT-1 immunolabelling of microvessel endothelium was significantly reduced in the AD compared to normal hippocampal formation. Thus, AD is associated with a reduction in cerebral microvessel endothelium glucose transporter content, which may result in decreased glucose availability to the brain.
authors.affiliation: Department of Anatomy, St. George's Hospital Medical School, Tooting, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Horwood
authors.forename: D C
authors.initials: DC
authors.lastname: Davies
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D051272:Glucose Transporter Type 1; D006624:Hippocampus / Q000098:blood supply*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008833:Microcirculation; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*
chemical_list: D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; C495677:SLC2A1 protein, human