Muscle differentiation. Which myogenic factors make muscle?
Mice lacking myogenin have little skeletal muscle as fibres fail to differentiate. Lack of both MyoD and myf-5 results in no skeletal muscle and apparently no myoblasts, suggesting that these factors act earlier in muscle development.
Buckingham
M
M
Department of Molecular Biology, Pasteur Institute, CNRS ERS 67, Paris, France.
D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins; D005314:Embryonic and Fetal Development; D015870:Gene Expression; D051379:Mice; D008817:Mice, Mutant Strains; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D009124:Muscle Proteins / Q000096:biosynthesis / Q000502:physiology*; D009132:Muscles / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D017570:MyoD Protein / Q000096:biosynthesis / Q000502:physiology*; D051787:Myogenic Regulatory Factor 5; D018008:Myogenin / Q000502:physiology*; D015534:Trans-Activators; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; D009124:Muscle Proteins; C497418:Myf5 protein, mouse; D017570:MyoD Protein; C503801:Myog protein, mouse; D051787:Myogenic Regulatory Factor 5; D018008:Myogenin; D015534:Trans-Activators; D014157:Transcription Factors