[Prevention of Rhesus incompatibility and viral safety].
Sporadic reports on hepatitis-B and NANB transmissions via intravenous immunoglobulin preparations (ivIg) and a series of NANB cases after administration of intramuscular immunoglobulin (imIg) for prophylaxis of immunisation against the Rhesus (Rh) antigen D (imIg-D) in the former Eastern Germany led us to investigate retrospectively the virus safety of imIg-D regarding transfusion-relevant viral infections. In 520 Rh-negative women, who had received a total number of 987 imIg-D injections over a period of 24 years from 1968 to the beginning of 1992, the parameters HBs-Ag, HIV-1,2-Ab, HCV-Ab, HBc-Ab and CMV-Ab were measured. A comparison of the results between the test group and a control group of Rh-positive women revealed no statistically significant differences. This underlines the virus safety of the imIg-D-preparations that have been in use in our area for the last 24 years.
Kirchebner
C
C
Zentralinstitut für Bluttransfusion und Immunologische Abteilung, Universitätskliniken Innsbruck.
Sölder
E
E
Schönitzer
D
D
D000328:Adult; D017848:Blood-Borne Pathogens; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000635:transmission* / Q000821:virology; D006526:Hepatitis C / Q000635:transmission* / Q000821:virology; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D007518:Isoantibodies / Q000008:administration & dosage*; D011247:Pregnancy; D012189:Retrospective Studies; D012203:Rh Isoimmunization / Q000097:blood / Q000517:prevention & control*; D018029:Rho(D) Immune Globulin
D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin
Rhesusprophylaxe und Virussicherheit.