Modification of the dissolution behaviour of a water-insoluble drug, naftazone, for zero-order release matrix preparation.
The preparation of hydrophilic matrix tablets able to release naftazone, a water-insoluble drug, into an aqueous medium at a constant rate (zero-order dissolution) is described. Enhancement of dissolution rate of the drug was achieved using cross-linked carmellose sodium, beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin. Hypromellose was used as a water-gelling polymer. Tablets could be prepared that released naftazone at a constant rate over 16 h.
Giunchedi
P
P
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
Maggi
L
L
La Manna
A
A
Conte
U
U
D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers; D009285:Naphthoquinones / Q000737:chemistry*; D010784:Photomicrography; D012995:Solubility; D013607:Tablets; D014867:Water
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009285:Naphthoquinones; D013607:Tablets; D014867:Water; C005272:naftazone