Soluble interleukin-2 receptor: a new marker in pancreatic adenocarcinoma?
An increase in soluble Interleukin-2 receptor has been observed in several lymphoproliferative diseases and in certain solid neoplasms. Little is known, however, of the serum levels of this marker in pancreatic cancer. We studied the behaviour of the soluble Interleukin-2 receptor in 32 patients with pancreatic cancer versus 17 patients with alcoholic chronic pancreatitis and 24 healthy controls. The results obtained showed a significant statistical difference (Student's "t"-test and Mann Whitney U test) between pancreatic cancer on one hand and chronic pancreatitis plus healthy controls on the other (p < 0.0001).
Rabitti
P G
PG
Centro Malattie del Pancreas, Ospedale A. Cardarelli, Napoli.
Pacelli
L
L
Uomo
G
G
Laccetti
M
M
Spada
O A
OA
Esposito
G
G
Visconti
M
M
D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D014408:Biomarkers, Tumor / Q000032:analysis*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis*; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2