Study of the stability and the kinetics of hydrolysis on the new potential antiarrhythmic "substance H + B".
"Substance H + B", N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-N- benzylpiperidine chloride (1) is a new potential antiarrhythmic, prepared by quarternization of the local anesthetic, antiarrhythmic and antimicrobial heptacaine, N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-piperidine chloride. The content of the work was a study of the stability of 1 based on the short-time stability tests of aqueous solutions, the observation of long-time storing of the substance and study of the kinetics of hydrolysis in aqueous, ethanolic buffer solutions. The conclusions of the presented results are: 1 is stable in acidic and neutral media, the alkaline hydrolysis is faster from the start compared to the hydrolysis of heptacaine, but later obtains an equilibrium character.
Stankovićová
M
M
Department of Pharmaceutical Chemistry, Pharmaceutical Faculty, Comenius University, Bratislava, Slovakia.
Bachratá
M
M
Bezáková
Z
Z
Blesová
M
M
Cizmárik
J
J
Sveda
P
P
D000889:Anti-Arrhythmia Agents / Q000737:chemistry*; D004355:Drug Stability; D006868:Hydrolysis; D007700:Kinetics; D010880:Piperidines / Q000737:chemistry*; D012996:Solutions; D013696:Temperature
D000889:Anti-Arrhythmia Agents; D010880:Piperidines; D012996:Solutions; C054661:N-2-(2-heptyloxyphenylcarbamoyloxy)ethyl-N-benzylpiperdinium