Molecular biology and the radiation oncologist.
An overview is provided of several recent advances in our understanding of the molecular events that occur when cells are exposed to ionizing radiation. A basic knowledge of molecular radiobiology is necessary so that the radiation oncologist can (i) screen cancer patients for an abnormally reduced or exaggerated response to radiotherapy; and (ii) devise novel ways to counter the molecular pathways that sustain malignant progression.
Kearsley
J H
JH
Department of Radiation Oncology, St George Hospital, Kogarah, NSW, Australia.
Lavin
M F
MF
D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects; D004249:DNA Damage / Q000528:radiation effects; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D008967:Molecular Biology; D009369:Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D018787:Radiation Oncology; D011853:Radiobiology