title: Synthesis and biological evaluation of derivatives of N-[4-substituted-1-piperazinylalkyl]-1-(butyl,aryl)-2,5- dimethylpyrrole-3,4-dicarboxymide (Part II).
abstract: A series of new N-[4-substituted-1-piperazinyl-alkyl]-3,4-pyrroledicarboxyimides 7 have been prepared by reaction of N-haloalkylimide derivatives 6 with corresponding N-monosubstituted piperazines. Compounds 7 tested in preliminary pharmacological investigation produced a general depressive action on the central nervous system.
authors.affiliation: Department of Drugs Chemistry, Medical Academy, Wroclaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Malinka
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: J
authors.initials: J
authors.lastname: Robak
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D002492:Central Nervous System Depressants; D010879:Piperazines; D011758:Pyrroles