Effect of partial hepatectomy on lactic dehydrogenase-5 clearance in mice.
The capacity of lactic dehydrogenase-5 (LDH-5) clearance of the liver following partial hepatectomy was investigated in ICR mice. Compared with sham-operated mice, the LDH-5 clearance rate was decreased slightly after the removal of 30 or 50%. Removal of approximately 65% of the liver induced a statistically significant decrease in the clearance rate. LDH activity in the blood was increased by the removal of about 50 and 65%, but not 30% of the liver. These results suggest that increase in LDH activity after hepatectomy may be due to decreased catabolic activity of the liver and the liver may play a significant role in the catabolism of LDH-5. The LDH-5 clearance capacity of the liver will be discussed.
Abe
F
F
Laboratories of Veterinary Hygiene, Yamaguchi University, Japan.
Hayashi
T
T
Iwata
H
H
Inoue
T
T
D000818:Animals; D006498:Hepatectomy; D007527:Isoenzymes; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000097:blood* / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008813:Mice, Inbred ICR; D012016:Reference Values; D013156:Splenectomy; D013997:Time Factors
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase