[Effectiveness of oral versus parenteral iron substitution in autologous blood donors].
OBJECTIVE
Is intravenous iron therapy as efficient as oral iron supplementation in patients undergoing autologous blood donation?


METHODS
Prospective, randomized study.


METHODS
30 male and 30 female patients, separated into two groups were examined prior to total hip replacement.


METHODS
Patients of group O were given 6 x 50 mg Fe2+ aspartate/day orally, and patients of group P were given 0.75 mg/kg BW complex-bound Fe3+ once a week by infusion. In both groups therapy was started two weeks prior to the first donation. The substitution was continued the following six weeks until surgery. Hemoglobin, ferritin plasma concentrations and reticulocytes were monitored. The appearance of unwanted side effects was studied by questionnaire.


RESULTS
Hb decreased significantly in both groups. A difference was seen in the reticulocyte count and in the ferritin levels. Here we found a significant increase in group P compared with group O. 40% of the patients who took the iron orally complained about unwanted side effects such as obstipation and diarrhoea, whereas none of the patients of the parenteral group had any complaints.


CONCLUSIONS
Stimulation of the erythropoiesis appeared to be more efficient with intravenous iron therapy than with oral iron supplementation. The oral dose has in about 40% unwanted side effects. For this reason a parenteral iron therapy can be considered, but one must be aware that in some cases dangerous anaphylactic reactions could appear.
Schindler
E
E
Abteilung Anaesthesiologie und Operative Intensivmedizin, Justus-Liebig-Universität Giessen.
Scholz
S
S
Boldt
J
J
Zickmann
B
B
Knothe
C
C
Dietrich
G
G
Hempelmann
G
G
D000284:Administration, Oral; D000368:Aged; D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D004906:Erythrocyte Count / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D006400:Hematocrit; D006452:Hemoglobinometry; D006622:Hip Prosthesis; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D005290:Ferric Compounds
Wirkung oraler versus parenteraler Eisensubstitution bei Eigenblutspendern.