title: Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.
abstract: The melanocortin peptides regulate a wide variety of physiological processes, including pigmentation and glucocorticoid production, and also have several activities in the central and peripheral nervous systems. The melanocortin receptor family includes the melanocyte-stimulating hormone receptor (MSH-R), adrenocorticotropic hormone receptor (ACTH-R), and two neural receptors, MC3-R and MC4-R. In the human these receptors map to 16q24 (MSH-R), 18p11.2 (ACTH-R), 20q13.2 (MC3-R), and 18q22 (MC4-R). The corresponding locations in the mouse are 8, 18, and 2; a variant for mapping MC4-R has not yet been identified. The data reported here also show that the neural MC3 receptor maps close to a disease locus for benign neonatal epilepsy in human and near the E1-2 epilepsy susceptibility locus in the mouse.
authors.affiliation: Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201.
authors.forename: R E
authors.initials: RE
authors.lastname: Magenis
authors.forename: L
authors.initials: L
authors.lastname: Smith
authors.forename: J H
authors.initials: JH
authors.lastname: Nadeau
authors.forename: K R
authors.initials: KR
authors.lastname: Johnson
authors.forename: K G
authors.initials: KG
authors.lastname: Mountjoy
authors.forename: R D
authors.initials: RD
authors.lastname: Cone
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D015342:DNA Probes / Q000235:genetics; D004827:Epilepsy / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D044104:Receptor, Melanocortin, Type 3; D044105:Receptor, Melanocortin, Type 4; D018043:Receptors, Corticotropin / Q000235:genetics*; D018000:Receptors, Peptide / Q000235:genetics*; D011979:Receptors, Pituitary Hormone / Q000235:genetics*; D013045:Species Specificity
chemical_list: D015342:DNA Probes; D044104:Receptor, Melanocortin, Type 3; D044105:Receptor, Melanocortin, Type 4; D018043:Receptors, Corticotropin; D018000:Receptors, Peptide; D011979:Receptors, Pituitary Hormone; C029446:MSH receptor