title: Methicillin-resistant Staphylococcus aureus endocarditis following patch closure of a ventricular septal defect: report of a case.
abstract: We report herein the case of a 5-month-old infant who, after developing methicillin-resistant Staphylococcus aureus (MRSA) endocarditis following patch closure of a ventricular septal defect (VSD), was successfully treated by replacement of the Dacron patch with an autogenous pericardial patch. Initially, a large perimembranous VSD was repaired with a Dacron patch and after an uneventful recovery of 1 week, he began to spike intermittent fevers from 38 degrees C to 39 degrees C. Two blood cultures grew MRSA and a two-dimensional echocardiogram performed 16 days after surgery showed an irregular mass attached to the right ventricular aspect of the Dacron patch. At reoperation, a large vegetation attached to the Dacron patch was confirmed, but there was no patch dehiscence. Following removal of the patch, the VSD was repaired with an autogenous pericardial patch, soon after which the fever rapidly subsided. Imipenem, 125 mg every 6 h, and fosfomycin, 300 mg every 6 h, were administered for a total of 24 days after reoperation. The child remains well 12 months after his second operation.
authors.affiliation: Second Department of Surgery, Kurume University School Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Aoyagi
authors.forename: T
authors.initials: T
authors.lastname: Kawara
authors.forename: T
authors.initials: T
authors.lastname: Mizoguchi
authors.forename: F
authors.initials: F
authors.lastname: Ando
authors.forename: T
authors.initials: T
authors.lastname: Yanai
authors.forename: E
authors.initials: E
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D004697:Endocarditis, Bacterial / Q000382:microbiology*; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D016106:Methicillin Resistance; D011093:Polyethylene Terephthalates; D011183:Postoperative Complications; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D011093:Polyethylene Terephthalates