title: Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.
abstract: Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I receptor. A girl with typical type A insulin resistant syndrome was treated with IGF-I for two years and the treatment was effective in ameliorating hyperglycaemia. Overproduction of testosterone in polycystic ovaries was aggravated with this treatment, however. Therefore, IGF-I treatment may be used for glycaemic control but with caution because of its possible side effect of aggravating hyperandrogenism in these patients.
authors.affiliation: Department of Paediatrics, Toyohashi Municipal Hospital, Aichi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishihama
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Muramatsu
authors.forename: M
authors.initials: M
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Kokubo
authors.forename: H
authors.initials: H
authors.lastname: Shiraya
authors.forename: A
authors.initials: A
authors.lastname: Kawakita
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Imamura
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000052:Acanthosis Nigricans / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003920:Diabetes Mellitus / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism; D013577:Syndrome; D013739:Testosterone / Q000096:biosynthesis* / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin