Synthesis and properties of N-(aminoalkyl)-4-acetyl-3,5-dimethylpyrrole-2-carboxamides hydrochlorides.
A series of N-(aminoalkyl)-4-acetyl-3,5-dimethylpyrrole-2-carboxamides hydrochlorides have been prepared and evaluated as cytostatic agents. General procedures were developed for constructing aminoalkyl chains on the 4-acetylpyrrole-2-carboxylic acid nuclei, utilizing 2-pyridone. The results of the preliminary biological activity have been mentioned.
Bielawski
K
K
Department of Organic Chemistry, Medical University Białystok.
Bołtryk
J
J
Bartulewicz
D
D
Krajewska
D
D
Rózański
A
A
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D011758:Pyrroles