title: Estrogen replacement therapy at menopause. How benefits outweigh risks.
abstract: Bone loss and cardiovascular disease are the most important complications of menopause. Because estrogen has been shown to prevent bone loss and also reduce fracture rates in menopausal women, the authors recommend early replacement therapy. They also examine evidence that estrogen replacement may offer these women protection from cardiovascular disease and discuss the risks of estrogen-related endometrial and breast cancer.
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, University of Missouri, Columbia School of Medicine.
authors.forename: G T
authors.initials: GT
authors.lastname: Griffing
authors.forename: S H
authors.initials: SH
authors.lastname: Allen
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008593:Menopause / Q000378:metabolism; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D012306:Risk
chemical_list: D004967:Estrogens