title: Fluvoxamine-associated sexual dysfunction.
abstract: OBJECTIVE
  To report two cases of sexual dysfunction induced by fluvoxamine, a selective serotonin reuptake inhibitor (SSRI).
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Two depressed patients who developed ejaculation and orgasmic difficulties after initiation of fluvoxamine therapy.
  
  
  CONCLUSIONS
  The literature concerning sexual dysfunction with serotonergic antidepressants is reviewed, and speculated mechanisms for this untoward effect are discussed.
  
  
  CONCLUSIONS
  Sexual dysfunction associated with antidepressant drugs, including SSRIs, may be underreported. This troublesome adverse effect may significantly affect patient comfort and compliance. Careful evaluation of sexual function is warranted, prior to and during drug treatment, especially as more serotonergic antidepressant agents become available.
authors.affiliation: Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Dorevitch
authors.forename: H
authors.initials: H
authors.lastname: Davis
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy; D007172:Erectile Dysfunction / Q000139:chemically induced; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects*; D006785:Hospitals, University; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced
chemical_list: D016666:Fluvoxamine