Determination of Kt/V and protein catabolic rate using pre- and postdialysis blood urea nitrogen concentrations.
We developed a new urea kinetic method for simultaneous determination of the Kt/V and protein catabolic rate (PCR) only from blood urea nitrogen (BUN) concentrations before and after a single dialysis session. Using this method, the parameters were calculated within 1.5 s even when a hand-held computer with a low central processing capacity is used. The total amount of urea eliminated during three dialysis sessions in 1 week is assumed to be equal to urea volume (Gw) generated over a 1-week period (Tw): [formula: see text]. Here, G is the generation rate, K is the dialyzer urea clearance, T is the dialysis time and C1, C2 and C3 are BUN during the respective dialysis session. If this equation and the equation expressing the urea kinetics during a single dialysis session are solved together, we have a solution for Kt/V and G. The thus-obtained Kt/V and G are corrected using the change in body weight. The corrected Kt/V showed a good correspondence with the parameter calculated with the classical method, and the midweek PCR derived from G determined by the present method being equivalent to the PCR averaged for a 1-week period determined by the classical methods.
Shinzato
T
T
Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Japan.
Nakai
S
S
Fujita
Y
Y
Takai
I
I
Morita
H
H
Nakane
K
K
Maeda
K
K
D001806:Blood Urea Nitrogen; D001835:Body Weight; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008433:Mathematics; D011506:Proteins / Q000378:metabolism*; D006435:Renal Dialysis; D014508:Urea / Q000378:metabolism*
D011506:Proteins; D014508:Urea