Loin pain-hematuria syndrome with a distinctive vascular lesion and alternative pathway complement activation.
We describe a 48-year-old woman with loin pain-hematuria syndrome. Her renal abnormalities included conspicuous microaneurysmal and glomeruloid (plexiform) angiomatous changes. The deposition of both properdin and the C5b-9 complex, as well as the usual C3, in arterioles argues for complement activation. To our knowledge, neither of these features has been previously described. We speculate about the cause of loin pain-hematuria syndrome and note the uncommonness of this entity in the United States as opposed to Great Britain.
Miller
F
F
Department of Pathology, School of Medicine, State University of New York-Stony Brook 11794-8691.
Lane
B P
BP
Kirsch
M
M
Ilamathi
E
E
Moore
B
B
Finger
M
M
D003170:Complement Pathway, Alternative; D005260:Female; D006417:Hematuria / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000098:blood supply / Q000473:pathology; D017116:Low Back Pain / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D013577:Syndrome