title: Caffeoylquinic acids and some biological activities of Pluchea symphytifolia.
abstract: From the aerial parts of Pluchea symphytifolia, four known and two new caffeoylquinic acids, 1,3,4,5-tetra-O-caffeoylquinic acid and 1,3-di-O-[3,4,-bis-(3,4-dihydroxyphenyl)-cyclobutane-1,2-dicarbonyl]- 4,5-di-O-caffeoylquinic acid, and two flavonols were isolated and their structures elucidated by mass and NMR spectroscopy and by chemical degradation. The aqueous extract had weak antibacterial and weak antisecretory effects; the lipophilic extract showed a modest anthelmintic activity. The higher caffeoylated quinic acids participated in the antibacterial and anthelmintic effect of the extracts.
authors.affiliation: Institut für Pharmazeutische Biologie der Universität, Freiburg/B., Federal Republic of Germany.
authors.forename: E
authors.initials: E
authors.lastname: Scholz
authors.forename: M
authors.initials: M
authors.lastname: Heinrich
authors.forename: D
authors.initials: D
authors.lastname: Hunkler
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D000871:Anthelmintics; D000890:Anti-Infective Agents; D011801:Quinic Acid