title: Normal lateralization for handedness and ear advantage in a verbal dichotic listening task in women with congenital adrenal hyperplasia (CAH).
abstract: Functional cerebral asymmetry was studied in 22 women, 17-34 years old, with prenatal virilization due to congenital adrenal hyperplasia (CAH) (21-hydroxylase deficiency) and 22 matched, healthy controls. The theory of an androgen influence on cerebral lateralization has been supported by the observation of sex differences in cognitive performance, anatomical cerebral differences between the sexes and atypical patterns of functional asymmetry in certain anomalous hormonal states. The result of the present study did however not show a significantly different pattern of functional asymmetry for women with CAH and prenatal exposure to high levels of androgens. No significant differences with the controls were found for the Finger Tapping Test (FTT), Edinburgh Handedness Inventory (EHI) or Dichotic Listening (Consonant-Vowel) Test (DL). The CAH group included four non-right-handers (18%) vs two (9%) in the control group. As sex differences generally are small, the present result, may have been influenced by the limited size of the sample.
authors.affiliation: Department of Psychiatry, Karolinska Institute, Huddinge University Hospital, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Helleday
authors.forename: B
authors.initials: B
authors.lastname: Siwers
authors.forename: E M
authors.initials: EM
authors.lastname: Ritzén
authors.forename: K
authors.initials: K
authors.lastname: Hugdahl
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000503:physiopathology* / Q000523:psychology; D000328:Adult; D001288:Attention / Q000502:physiology*; D004007:Dichotic Listening Tests; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D011939:Mental Recall / Q000502:physiology; D009483:Neuropsychological Tests; D012727:Sex Characteristics; D014770:Virilism / Q000503:physiopathology / Q000523:psychology