Implications of the SNARE hypothesis for intracellular membrane topology and dynamics.
The SNARE hypothesis provides a mechanism for the specific docking and fusion of transport vesicles with their target membranes. A simple extension of the hypothesis can explain many cellular processes, including the stacking of Golgi cisternae, retrograde transport and homotypic fusion; it can also explain the morphology of intracellular membranes and their dynamics during mitosis.
Rothman
J E
JE
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Warren
G
G
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology; D007425:Intracellular Membranes / Q000502:physiology* / Q000648:ultrastructure; D008561:Membrane Fusion / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000502:physiology; D050683:R-SNARE Proteins; D052067:Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D050683:R-SNARE Proteins; D052067:Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins; D033921:Vesicular Transport Proteins; D019204:GTP-Binding Proteins