Oxygen consumption-oxygen delivery dependency in adult respiratory distress syndrome.
Considerable attention has been directed toward the study of oxygen transport principles in the adult respiratory distress syndrome (ARDS). In particular, concerns have been voiced regarding disturbed tissue oxygen extraction creating a pathologic dependency of oxygen consumption on oxygen delivery. This article discusses oxygen transport principles, data relevant to the oxygen extraction controversy, and implications regarding the pathogenesis and potential therapies for ARDS.
Knox
J B
JB
Surgical Intensive Care Unit, Harvard Medical School, Boston, MA.
D015982:Bias; D002302:Cardiac Output; D016887:Cardiopulmonary Resuscitation; D003422:Critical Care; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology; D010101:Oxygen Consumption; D015203:Reproducibility of Results; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy