TAP1 and TAP2 polymorphism in multiple sclerosis patients.
The frequency of TAP1 and TAP2 gene polymorphisms in MS patients was compared with that of a normal population. A significant increase in TAP2-379-VAL homozygosity and TAP2-565-ALA homozygosity was found in HLA-DRB1*1501-DQB1*0602-negative patients.
Middleton
D
D
Northern Ireland Tissue Typing Service, City Hospital.
Megaw
G
G
Cullen
C
C
Hawkins
S
S
Darke
C
C
Savage
D A
DA
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D006684:HLA-DR Antigens; C073119:TAP1 protein, human; C071692:TAP2 protein, human