[Study on intratumor administration of lentinan--primary changes in cancerous tissues].
Lentinan was administered for gastric cancer in order to determine what type of changes would occur as a consequence. In an experimental study, the intraperitoneal administration of lentinan on cancerous tissues caused a marked development of reticular fibers, along with an enhanced interstitial response. Findings which support the relationship between a marked development of reticular fibers and an anti-tumor effect, were also obtained. Furthermore, lentinan was administered for human gastric cancer to evaluate whether or not an increase in interstitial response would be observed. As a result, reticular fibers developed in tumor sites with a resultant fragmentation of cancer cell nests. Many T lymphocytes infiltrated cancer sites where the lentinan was administered. These findings suggest that the intratumor administration of lentinan enhanced an interstitial response and also activated an anti-tumor immune response in the human gastric cancer tissues.
Ogawa
K
K
Dept. of Surgery, Tokyo Women's Medical College Daini Hospital.
Watanabe
T
T
Katsube
T
T
Miura
K
K
Hirai
M
M
Wakasugi
S
S
Yagawa
H
H
Kajiwara
T
T
Suga
T
T
Hamuro
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D007274:Injections, Intraperitoneal; D007912:Lentinan / Q000008:administration & dosage*; D051379:Mice; D009368:Neoplasm Transplantation; D016622:Silver Staining; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D000970:Antineoplastic Agents; D007912:Lentinan