title: Prospective, randomized comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure.
abstract: OBJECTIVE
  To compare the effectiveness of high-frequency oscillatory ventilation with conventional mechanical ventilation in pediatric patients with respiratory failure.
  
  
  METHODS
  Five tertiary care pediatric intensive care units.
  
  
  METHODS
  A prospective, randomized, clinical study with crossover.
  
  
  METHODS
  Seventy patients with either diffuse alveolar disease and/or airleak syndrome were randomized to receive high-frequency oscillatory ventilation or conventional mechanical ventilation.
  
  
  METHODS
  Patients randomized to receive high-frequency oscillatory ventilation were managed, using a strategy that consisted of aggressive increases in mean airway pressure to attain the "ideal" lung volume and to achieve an arterial oxygen saturation of > or = 90%, with an FIO2 of < or = 0.6. Patients who were randomized to receive conventional mechanical ventilation were treated with a strategy that utilized increases in end-expiratory pressure and inspiratory time to increase mean airway pressure and to limit increases in peak inspiratory pressure. Target blood gas values were the same for both groups. Crossover to the alternate ventilator was required if the patient met defined criteria for treatment failure.
  
  
  RESULTS
  Physiologic data and ventilatory parameters were collected prospectively at predetermined intervals after randomization. Airleak Scores were derived daily, based on the chest radiograph and the patient's clinical condition. In the high-frequency oscillatory ventilation group, the PaO2/PAO2 ratio increased significantly and the oxygenation index (mean airway pressure x FIO2 x 100/PaO2) decreased significantly over time. There were no differences between the groups in duration of mechanical ventilation, frequency of airleak, Airleak Scores, or 30-day survival rates. Significantly fewer patients treated with high-frequency oscillatory ventilation required supplemental oxygenation at 30 days compared with patients managed with conventional ventilation. When ventilatory subgroups were compared, the patients managed with high-frequency oscillation only had significantly better ranked outcomes than patients managed with conventional ventilation only.
  
  
  CONCLUSIONS
  Our results indicate that high-frequency oscillatory ventilation, utilizing an aggressive volume recruitment strategy, results in significant improvement in oxygenation compared with a conventional ventilatory strategy designed to limit increases in peak airway pressures. Furthermore, despite the use of higher mean airway pressures, the optimal lung volume strategy used in this study was associated with a lower frequency of barotrauma, as indicated by requirement for supplemental oxygen at 30 days, and improved outcome compared with conventional mechanical ventilation.
authors.affiliation: Department of Anesthesia, Children's Hospital, Boston, MA 02115.
authors.forename: J H
authors.initials: JH
authors.lastname: Arnold
authors.forename: J H
authors.initials: JH
authors.lastname: Hanson
authors.forename: L O
authors.initials: LO
authors.lastname: Toro-Figuero
authors.forename: J
authors.initials: J
authors.lastname: Gutiérrez
authors.forename: R J
authors.initials: RJ
authors.lastname: Berens
authors.forename: D L
authors.initials: DL
authors.lastname: Anglin
mesh_terms: D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D005260:Female; D006439:Hemodynamics; D006612:High-Frequency Ventilation; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008297:Male; D011175:Positive-Pressure Respiration; D011379:Prognosis; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000401:mortality / Q000628:therapy*