Long-term evolution and growth patterns in a family with Bartter's syndrome.
The five-year evolution of three siblings of a sibship affected by a combined potassium and magnesium wasting abnormality associated with hypocalciuria is presented. Fractional distal chloride reabsorption was low. A number of therapeutic measures were attempted with partial or no success. Consequently, patients were kept on oral potassium and magnesium supplementation only. Special attention was paid to nutritional status. Although the three girls maintained a plasma potassium range of 2.6 to 3 meq/l, sexual and mental maturation were not delayed. Growth remained within the lower limits of normality. Considering the poor results obtained from treatment and the side-effects, we conclude that this long-term approach is sound, at least, in less severe cases of Bartter's syndrome.
Marco-Franco
J E
JE
Nephrology Department, Son Dureta General Hospital, Palma de Mallorca, Spain.
Morey
A
A
Ventura
C
C
Gascó
J M
JM
Alarcón
A
A
D001477:Bartter Syndrome / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D002648:Child; D004200:Diseases in Twins / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000502:physiology*; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D011189:Potassium Chloride / Q000627:therapeutic use; D013997:Time Factors
D011189:Potassium Chloride; D008274:Magnesium