title: Karyometry of primary and metastatic malignant melanoma. A correlation with cell proliferation.
abstract: We used computerized image analysis, immunohistochemistry, and the incorporation of tritiated thymidine to study the relationship between nuclear size and shape and the proliferation of malignant melanoma cells. A total of 30 nonulcerated primary malignant melanomas and 75 of their cutaneous metastases were considered. We found a positive relationship between (a) the 3H-TdR labeling indices and the thickness of the primary malignant melanoma: (b) the nuclear profile areas of primary lesions and their respective metastases; and (c) the size and regularity of the contours of the nuclei. We failed to find a relationship between 3H-TdR indices and the nuclear size of malignant melanoma cells.
authors.affiliation: Department of Dermatopathology, University of Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Piérard-Franchimont
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D006801:Humans; D007620:Karyometry; D008545:Melanoma / Q000378:metabolism / Q000473:pathology / Q000556:secondary / Q000648:ultrastructure*; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D013936:Thymidine / Q000378:metabolism
chemical_list: D013936:Thymidine