title: Hypolipidemic activity of tincture of Crataegus in rats.
abstract: Tincture of Crataegus (TCR), an alcoholic extract of the berries of Crataegus oxyacantha, when administered to rats fed a hyperlipidemic diet (HLD), could prevent the elevation in plasma lipid levels. A significant decrease in lipid deposits in liver and aorta was also observed. Analysis of the plasma lipoprotein profile showed that TCR produced remarkable reduction in the increased levels of cholesterol, triglycerides and phospholipids in the low density lipoprotein (LDL) and very low density lipoprotein (VLDL) fractions in hyperlipidemic rats. Histological examination showed severe fatty vacuolation and degeneration of liver of HLD fed rats. TCR administration had an ameliorating effect on these changes. Agarose gel electrophoretic pattern of plasma lipoproteins also indicated that the drug brought down the raised levels of the atherogenic beta-lipoproteins in hyperlipidemic rats.
authors.affiliation: Department of Biochemistry, University of Madras.
authors.forename: S
authors.initials: S
authors.lastname: Shanthi
authors.forename: K
authors.initials: K
authors.lastname: Parasakthy
authors.forename: P D
authors.initials: PD
authors.lastname: Deepalakshmi
authors.forename: S N
authors.initials: SN
authors.lastname: Devaraj
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D006949:Hyperlipidemias / Q000097:blood / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D010743:Phospholipids / Q000097:blood; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010743:Phospholipids; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol