title: Sustained-release isradipine compared with spirapril in the treatment of elderly patients with isolated systolic hypertension.
abstract: The benefits of treating isolated systolic hypertension (ISH) have been established, but the most appropriate choice of drug is still uncertain. For this reason, a sustained-release formulation of isradipine was compared with spirapril in a double-blind randomized study in elderly Chinese patients with ISH. The dosage was titrated if necessary after 4 weeks of treatment. The reduction in systolic/diastolic blood pressure after 8 weeks was similar for both treatments--20/10 mm Hg with isradipine versus 24/6 mm Hg with spirapril--measured in the supine position. There were no orthostatic symptoms and both treatments were well tolerated.
authors.affiliation: Department of Clinical Pharmacology, Chinese University of Hong Kong, Shatin, New Territories.
authors.forename: B
authors.initials: B
authors.lastname: Tomlinson
authors.forename: J
authors.initials: J
authors.lastname: Woo
authors.forename: J A
authors.initials: JA
authors.lastname: Critchley
authors.forename: K K
authors.initials: KK
authors.lastname: Or
authors.forename: T Y
authors.initials: TY
authors.lastname: Chan
authors.forename: J E
authors.initials: JE
authors.lastname: Sanderson
mesh_terms: D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004656:Enalapril / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017275:Isradipine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D013599:Systole
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D003692:Delayed-Action Preparations; D004656:Enalapril; C052555:spirapril; D017275:Isradipine