Properties and regulation of the renal vacuolar H(+)-ATPase and H(+)-K(+)-ATPase.
Two proton-transporting ATPases participate in active proton transport in the nephron: the electrogenic vacuolar H(+)-ATPase and the electroneutral H(+)-K(+)-ATPase. The vacuolar H(+)-ATPase participates in proximal and distal hydrogen ion secretion related to acid-base homeostasis. The H(+)-K(+)-ATPase is located exclusively in the distal nephron, and its primary role may be in active potassium reabsorption. The properties, distribution, and regulation of these two enzymes are discussed.
Gluck
S L
SL
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Nelson
R D
RD
Lee
B S
BS
D000818:Animals; D005033:Ethylmaleimide / Q000494:pharmacology; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D014018:Tissue Distribution; D014617:Vacuoles / Q000201:enzymology
D017506:H(+)-K(+)-Exchanging ATPase; D006180:Proton-Translocating ATPases; D005033:Ethylmaleimide