Inhibition of T3-receptor binding by Nitrofen.
Lung development is controlled by various hormones, including thyroid hormone. The herbicide 2,4-dichlorophenyl-p-nitrophenyl ether (Nitrofen) induces lung hypoplasia in fetal rats, when administered to the mother during gestation. Nitrofen might be teratogenic by an anti-thyroid activity. The present study shows that Nitrofen decreases the binding of T3 to the alpha 1 and beta 1 form of the thyroid hormone receptor in a non-competitive way. Consequently, rat lung hypoplasia might result from the decreased binding of T3 to its receptor, via exposure to Nitrofen during fetal development.
Brandsma
A E
AE
Department of Pediatric Surgery, University of Rotterdam, The Netherlands.
Tibboel
D
D
Vulto
I M
IM
de Vijlder
J J
JJ
Ten Have-Opbroek
A A
AA
Wiersinga
W M
WM
D000818:Animals; D002645:Chickens; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004926:Escherichia coli / Q000235:genetics; D005822:Genetic Vectors; D006540:Herbicides / Q000633:toxicity*; D008168:Lung / Q000187:drug effects / Q000196:embryology; D010647:Phenyl Ethers / Q000633:toxicity*; D051381:Rats; D011988:Receptors, Thyroid Hormone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D013974:Thyroxine / Q000378:metabolism*
D006540:Herbicides; D010647:Phenyl Ethers; D011988:Receptors, Thyroid Hormone; D011993:Recombinant Fusion Proteins; C007350:nitrofen; D013974:Thyroxine