Insulin-like growth factors and their receptors in normal physiology and pathological states.
The insulin-like growth factor system, which includes the IGFs, IGF-binding proteins and IGF receptors, plays an essential role in normal growth and development, as well as the cellular differentiation of a number of other important systems, including the reproductive and immune systems. IGF action has also been implicated in several pathological conditions, including tissue repair, malnutrition, diabetes and malignancy.
LeRoith
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Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Roberts
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D000818:Animals; D006130:Growth Disorders / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D017451:Receptors, Somatomedin / Q000378:metabolism*; D012016:Reference Values; D012038:Regeneration / Q000502:physiology; D013002:Somatomedins / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
D017451:Receptors, Somatomedin; D013002:Somatomedins