Association among an autocrine parameter (EGF-R) and endocrine parameters (ER and PR) in locoregional breast cancer.
Sixty-three locoregional breast cancer biopsies were examined for association among epidermal growth factor receptors (as parameter of autocrine growth control), and estrogen and progesterone receptors (as endocrine parameters of estrogen responsiveness). In the tumor group with similar steroid receptor levels, low (0-50 fmol/mg), medium (50-100 fmol/mg) and high (above 100 fmol/mg), an inverse quantitative correlation between epidermal growth factor receptors and progesterone receptors was obtained (p < 0.05). In the tumor groups where estrogen receptor levels were higher or lower than progesterone receptor levels, epidermal growth factor receptors were correlated neither with estrogen nor with progesterone receptors (p > 0.05). It seemed that inverse correlation between endocrine and autocrine parameters obtained in previous studies might not be a common behaviour of all breast tumors.
Nikolić-Vukosavljević
D
D
Institute of Oncology and Radiology, Belgrade, Yugoslavia.
Kanjer
K
K
Branković-Magić
M
M
Spuzić
I
I
D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology* / Q000648:ultrastructure*; D002455:Cell Division / Q000502:physiology; D066246:ErbB Receptors / Q000032:analysis / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis / Q000502:physiology*; D011980:Receptors, Progesterone / Q000032:analysis / Q000502:physiology*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D066246:ErbB Receptors