Gender differences in lipid alterations following combined pancreas-kidney transplantation.
We have previously demonstrated that the lipid profile improves following successful combined pancreas-kidney transplantation (PKT). In this study, we examined whether changes in the lipid profile were different in men than in women following PKT. Fasting total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), and the TC to HDL ratio (TC/HDL) were evaluated in 47 patients (27 men and 20 women) with normal graft function following PKT. Lipids were evaluated at regular intervals 3.5 months to 2.2 years post-PKT (a total of 317 observations). After PKT, TC/HDL decreased (P < .05), TC was unchanged, and HDL increased (P < .05) in both men and women. Although TG decreased in both men and women, it reached statistical significance in men only (P < .05). There were no significant differences in any lipid parameters between men and women before PKT, but after PKT, TC, TG, and HDL were higher in women (240 +/- 11, 183 +/- 17, and 64 +/- 19 mg/dL, respectively) than in men (207 +/- 6, 143 +/- 11, and 53 +/- 2 mg/dL, P < .05 for each). When post-PKT values were analyzed for trends over time, both TC and TG decreased (P < .05 for both) without any significant difference in trends between men and women. When six individuals who had received lovastatin at any time during their postoperative course were removed from analysis, the gender differences in TG post-PKT and the decrease in TG over time were no longer statistically significant (P > .05).(ABSTRACT TRUNCATED AT 250 WORDS)
Larsen
J L
JL
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-3020.
Forsman
J A
JA
Hirst
K
K
Miller
S
S
Taylor
R J
RJ
Stratta
R J
RJ
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D003928:Diabetic Nephropathies / Q000601:surgery; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D016381:Islets of Langerhans Transplantation; D016030:Kidney Transplantation; D008055:Lipids / Q000097:blood*; D008148:Lovastatin / Q000627:therapeutic use; D008297:Male; D008597:Menstrual Cycle; D011184:Postoperative Period; D011388:Prolactin / Q000097:blood; D051437:Renal Insufficiency / Q000601:surgery; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood
D000319:Adrenergic beta-Antagonists; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D011388:Prolactin; D002784:Cholesterol; D008148:Lovastatin; D003404:Creatinine