Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives.
The synthesis of 4-adamantyl-5-aryl-3-phenyl-delta 2-1,2,4-oxadiazolines, involving an 1,3-dipolar cycloaddition reaction between 1-[(arylidene)amino]adamantanes and benzonitriloxide, is described. The evaluation of in vitro antiviral activity against human immunodeficiency virus (HIV) of the compounds obtained is also reported.
Chimirri
A
A
Dipartimento Farmaco-Chimico, Università di Messina, Italy.
Grasso
S
S
Monforte
A M
AM
Monforte
P
P
Zappalà
M
M
Carotti
A
A
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans; D010069:Oxadiazoles / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D010069:Oxadiazoles