[Expression and significance of immunosuppressive acidic protein (IAP) in human esophageal squamous cell carcinoma].
The expression of IAP in the esophageal tissues of 74 patients with esophageal squamous cell carcinoma and 12 normal controls were determined by using MI2, and anti-IAP monoclonal antibody, and ABC immunohistochemical staining. The results showed that there was no expression of IAP in normal esophageal epithelium of all control subjects, and the positive rate in specimens of the esophageal carcinomas was 90.3% (P < 0.001). The staining intensity of IAP was increasing with the decrease in degrees of cell differentiation of the tumors (P < 0.05). The expression of IAP in long survivors without lymph node metastasis were lower than that in cases with metastasis (P < 0.005) and short survivors (P < 0.001). The results suggest that IAP may play an important role in tumor cell differentiation, clinical course and prognosis of esophageal carcinoma, and may be used as a tumor marker for the diagnosis of this malignancy.
Guo
S Z
SZ
Department of Precancerous Pathology, Henan Medical University, Zhengzhou.
Shen
Q
Q
Zhang
H B
HB
D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D002454:Cell Differentiation; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009363:Neoplasm Proteins / Q000032:analysis* / Q000276:immunology; D011379:Prognosis
D000911:Antibodies, Monoclonal; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein