Myelodysplasia following paroxysmal nocturnal haemoglobinuria: evidence for the emergence of a separate clone.
A patient with paroxysmal nocturnal haemoglobinuria (PNH) who developed a myelodysplastic syndrome (MDS) is described. After the onset of myelodysplasia the neutrophils of the patient fully expressed GPI-linked proteins. It is concluded that the myelodysplasia does not originate from transformed PNH stem cells, but represents the emergence of a separate clone arising from an injured marrow.
van Kamp
H
H
Department of Haematology, University of Groningen, The Netherlands.
Smit
J W
JW
van den Berg
E
E
Ruud Halie
M
M
Vellenga
E
E
D000754:Anemia, Refractory, with Excess of Blasts / Q000097:blood / Q000150:complications* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002999:Clone Cells / Q000473:pathology; D017261:Glycosylphosphatidylinositols / Q000097:blood; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism
D017261:Glycosylphosphatidylinositols