Evidence for a multigenic system controlling methyl-beta-carboline-3-carboxylate (beta-CCM)-induced seizures.
beta-CCM is a beta-carboline known to have properties opposite to those of benzodiazepines. Our approach was to analyze, in mice, the genetic mechanisms involved in beta-CCM-induced myoclonic seizures using recombinant congenic strains and F1 hybrids issued from these strains. Our aim was to define the extent of the multigenic character of beta-CCM-induced myoclonic seizures, while also evaluating the distribution of the strength of the genes implicated in this trait. The results show that the control of reactivity to beta-CCM is multigenic with notable epistatic involvement.
Martin
B
B
URA 1294-CNRS, UFR Biomédicale Paris V, France.
Marchaland
C
C
Chapouthier
G
G
Motta
R
R
D000818:Animals; D002243:Carbolines; D003292:Convulsants; D004831:Epilepsies, Myoclonic / Q000139:chemically induced / Q000235:genetics*; D004843:Epistasis, Genetic; D005260:Female; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008957:Models, Genetic; D005810:Multigene Family; D011995:Recombination, Genetic
D002243:Carbolines; D003292:Convulsants; C036150:beta-carboline-3-carboxylic acid methyl ester