title: PRINTS--a database of protein motif fingerprints.
abstract: PRINTS is a compendium of protein motif 'fingerprints'. A fingerprint is defined as a group of motifs excised from conserved regions of a sequence alignment, whose diagnostic power or potency is refined by iterative databasescanning (in this case the OWL composite sequence database). Generally, the motifs do not overlap, but are separated along a sequence, though they may be contiguous in 3D-space. The use of groups of independent, linearly- or spatially-distinct motifs allows protein folds and functionalities to be characterised more flexibly and powerfully than conventional single-component patterns or regular expressions. The current version of the database contains 200 entries (encoding 950 motifs), covering a wide range of globular and membrane proteins, modular polypeptides, and so on. The growth of the databaseis influenced by a number of factors; e.g. the use of multiple motifs; the maximisation of sequence information through iterative database scanning; and the fact that the database searched is a large composite. The information contained within PRINTS is distinct from, but complementary to the consensus expressions stored in the widely-used PROSITE dictionary of patterns.
authors.affiliation: Department of Biochemistry, University of Leeds, UK.
authors.forename: T K
authors.initials: TK
authors.lastname: Attwood
authors.forename: M E
authors.initials: ME
authors.lastname: Beck
authors.forename: A J
authors.initials: AJ
authors.lastname: Bleasby
authors.forename: D J
authors.initials: DJ
authors.lastname: Parry-Smith
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids; D003195:Computer Communication Networks; D017124:Conserved Sequence; D016208:Databases, Factual; D008969:Molecular Sequence Data; D010449:Peptide Mapping; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D000596:Amino Acids; D011506:Proteins