title: Minimal increase in serum interleukin-6 levels during laparoscopic cholecystectomy.
abstract: The chronologic changes in the serum levels of interleukin-6 (IL-6), a mediator for acute-phase inflammation, were compared between laparoscopic cholecystectomy (LC) and open cholecystectomy (OC), since these two types of operations were considered to be a unique model for examining the role of local tissue injury in postoperative inflammatory reactions. The increase in the serum IL-6 level during LC was found to be significantly smaller than that during OC and resulted in a smaller extent of postoperative elevations for C-reactive protein. These results suggest that laparoscopic surgery associated with minimal tissue injury can help limit an increase in the serum IL-6 level during surgery, thus contributing to a reduction in surgical stress.
authors.affiliation: Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ueo
authors.forename: M
authors.initials: M
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: S
authors.initials: S
authors.lastname: Arinaga
authors.forename: T
authors.initials: T
authors.lastname: Akiyoshi
mesh_terms: D015415:Biomarkers / Q000097:blood; D001831:Body Temperature; D002097:C-Reactive Protein / Q000032:analysis*; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000517:prevention & control; D015850:Interleukin-6 / Q000097:blood*; D016343:Monitoring, Intraoperative; D011183:Postoperative Complications / Q000097:blood* / Q000503:physiopathology / Q000517:prevention & control; D013997:Time Factors
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein