[Hepatic arterial infusion after hepatectomy for liver metastases of colorectal carcinoma to prevent residual hepatic recurrence].
The hepatic recurrent rate after hepatic resection of colorectal liver metastases was 60-70%. Prevention of residual hepatic recurrence will result in a markedly better prognostic outcome. Thus, 51 patients with liver metastases of colorectal carcinoma were administered 5-FU from gastroduodenal artery after hepatectomy. The results were as follows: the cumulative 5-year survival rate; hepatic arterial infusion (+): 43.4%; (-): 18.5% (p < 0.05); the residual hepatic recurrent rate, hepatic arterial infusion (+): 33.3%; (-): 58.6% (p < 0.05); The total dose of 5-FU > or = 15 g administration group got less residual hepatic recurrent rate; and proved rather effective for prevention of residual hepatic recurrence. But the 5-year survival rate in extra-hepatic recurrence (+) was 14.1% and that of (-) was 70.9% (p < 0.001). In future, it will be necessary to prevent extra-hepatic recurrence after hepatectomy.
Takahashi
K
K
Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
Mori
T
T
Takahashi
T
T
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D018365:Neoplasm, Residual; D011379:Prognosis
D005467:Floxuridine; D005472:Fluorouracil; C025034:doxifluridine