The study of health effects of vinyl chloride air pollution on population.
A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR), gamma-GT, GPT and AKP, were employed in the present survey among occupationally vinyl chloride (VC) exposed workers and inhabitants living in VC polluted area in a polyvinyl chloride (PVC) factory. The results showed that the serum lysozyme (S-LZM) activities in Group 3 (adult inhabitants exposed to 0.20 mg/m3 VC for at least 8 years), Group 2 (workers exposed to 4.1 mg/m3 for at least 7 years occupationally), Group 1 (workers exposed to 25.7 mg/m3 for at least 2 years) were significantly higher than control. G-banding CA analysis showed that the total chromosome breakage rates in both Groups 1 and 2 were higher, but no difference existed between Group 3 and control. Only Group 1 was observed having higher SCEs, CA level and lower TcTR than control. AKP levels in Groups 1 and 2 were higher than control, but no gamm-GT and GPT differences were found among groups. The study also suggests that G-banding CA analysis is more sensitive than CA and SCEs.
Zhao
M Y
MY
Department of Environmental Health, School of Public Health, Tongji Medical University, Wuhan, China.
Ying
C J
CJ
Shao
N
N
Yang
Y
Y
Yang
C F
CF
Shi
L
L
Liu
W Q
WQ
D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000494:pharmacology*; D000395:Air Pollutants, Occupational / Q000494:pharmacology*; D002648:Child; D002869:Chromosome Aberrations; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D009113:Muramidase / Q000097:blood / Q000187:drug effects; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014752:Vinyl Chloride / Q000494:pharmacology*
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D009113:Muramidase; D014752:Vinyl Chloride