title: Circulating intercellular adhesion molecule-1 (cICAM-1) concentration in liver disease. Relationship with cholestasis and functioning hepatic mass.
abstract: The authors measured immunoenzymatically circulating intercellular adhesion molecule-1 (cICAM-1) concentration in 135 patients with liver disease of either viral or toxic etiology: 13 had acute hepatitis; 58 had mild chronic liver disease; and 64 had cirrhosis (superimposed in 30 by hepatocellular carcinoma). Forty patients with extrahepatic diseases (19 with malignancies) and 28 healthy blood donors were tested as controls. One-way analysis of variance demonstrated a significant variability of cICAM-1 concentration among groups (F = 76.67, P < .0001), the highest value being recorded in acute hepatitis (Bonferroni's test for pairwise comparisons, P < .01). Total bilirubin showed a strong correlation with cICAM-1 (R = 0.766, P < .001). By stepwise multiple regression analysis the independent predictors of cICAM-1 concentration were chosen in the following order: total bilirubin; aspartate aminotransferase; cholinesterase; alpha-1-antitrypsin; and immunoglobulins. Thus, in addition to inflammation, cholestasis and decline of functioning hepatic mass may influence cICAM-1 concentration.
authors.affiliation: Cattedra di Medicina Interna, Università degli Studi, Udine, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pirisi
authors.forename: E
authors.initials: E
authors.lastname: Falleti
authors.forename: C
authors.initials: C
authors.lastname: Fabris
authors.forename: G
authors.initials: G
authors.lastname: Soardo
authors.forename: P
authors.initials: P
authors.lastname: Toniutto
authors.forename: D
authors.initials: D
authors.lastname: Vitulli
authors.forename: F
authors.initials: F
authors.lastname: Pezzetta
authors.forename: N
authors.initials: N
authors.lastname: Bortolotti
authors.forename: F
authors.initials: F
authors.lastname: Gonano
authors.forename: E
authors.initials: E
authors.lastname: Bartoli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002780:Cholestasis, Intrahepatic / Q000097:blood; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008107:Liver Diseases / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D018799:Intercellular Adhesion Molecule-1