Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia.
In 31 cases of chronic myelogenous leukaemia (CML) we examined the prognostic significance of chromosomal loss of a 17p and p53 mutations at the onset of blast crisis (BC). p53 mutations were closely related to a shortened survival in CML-BC (P < 0.005 by the logrank test), whereas loss of a 17p by itself was not a poor prognostic indicator. The prognostic significance of loss of a 17p, however, emerged when combined with its predominance in the metaphases analysed. This predominance might easily and rapidly be screened by polymerase chain reaction-based analysis in about half of the cases.
Nakai
H
H
Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Misawa
S
S
Taniwaki
M
M
Horiike
S
S
Takashima
T
T
Seriu
T
T
Nakagawa
H
H
Fujii
H
H
Shimazaki
C
C
Maruo
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D001752:Blast Crisis; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D016158:Genes, p53; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011379:Prognosis