Involvement of folic acid and methionine in the synthesis of certain membrane-associated nucleotide sugars by Enterococcus hirae.
A membrane preparation from Enterococcus hirae contained UDP and methyl-UDP (mUDP) monosaccharides. This preparation, when incubated with combinations of folic acid, L-serine, and S-adenosyl-L-methionine in a reaction system containing UDP-glucose, promoted synthesis of certain mUDP sugars. Folic acid and serine produced mUDP-glucose and mUDP-rhamnose; S-adenosylmethionine produced mUDP-glucose, mUDP-mannose, and mUDP-fucose.
Wood
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RC
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555-1019.
D002458:Cell Fractionation; D002462:Cell Membrane / Q000378:metabolism*; D002474:Cell-Free System; D016983:Enterococcus / Q000378:metabolism*; D005492:Folic Acid / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism*; D009005:Monosaccharides / Q000032:analysis; D012436:S-Adenosylmethionine / Q000378:metabolism; D012694:Serine / Q000378:metabolism; D014532:Uridine Diphosphate Glucose / Q000378:metabolism; D014539:Uridine Diphosphate Sugars / Q000096:biosynthesis* / Q000737:chemistry
D009005:Monosaccharides; D014539:Uridine Diphosphate Sugars; D012694:Serine; D012436:S-Adenosylmethionine; D005492:Folic Acid; D008715:Methionine; D014532:Uridine Diphosphate Glucose