Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.
Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I receptor. A girl with typical type A insulin resistant syndrome was treated with IGF-I for two years and the treatment was effective in ameliorating hyperglycaemia. Overproduction of testosterone in polycystic ovaries was aggravated with this treatment, however. Therefore, IGF-I treatment may be used for glycaemic control but with caution because of its possible side effect of aggravating hyperandrogenism in these patients.
Ishihama
H
H
Department of Paediatrics, Toyohashi Municipal Hospital, Aichi, Japan.
Suzuki
Y
Y
Muramatsu
K
K
Nagai
M
M
Kokubo
M
M
Shiraya
H
H
Kawakita
A
A
Nishimura
Y
Y
Imamura
T
T
Kobayashi
M
M
D000052:Acanthosis Nigricans / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003920:Diabetes Mellitus / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism; D013577:Syndrome; D013739:Testosterone / Q000096:biosynthesis* / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin