title: Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy.
abstract: Children with spinal muscular atrophy were treated by the administration of thyrotropin-releasing hormone. In three infants with spinal muscular atrophy type I, thyrotropin-releasing hormone showed little efficacy, but in children with types II and III, there was improvement in motor function and electromyographic findings after the thyrotropin-releasing hormone therapy. Thyrotropin-releasing hormone has a neurotrophic effect on the spinal anterior motor neurons of spinal muscular atrophy patients and thus may be warranted for the management of spinal muscular atrophy.
authors.affiliation: Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Miyanomae
authors.forename: H
authors.initials: H
authors.lastname: Komatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Oomizono
authors.forename: A
authors.initials: A
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Okano
authors.forename: T
authors.initials: T
authors.lastname: Nishiki
authors.forename: T
authors.initials: T
authors.lastname: Sawada
mesh_terms: D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008475:Median Nerve; D009046:Motor Neurons / Q000187:drug effects; D012720:Severity of Illness Index; D014897:Spinal Muscular Atrophies of Childhood / Q000188:drug therapy*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D013979:Tibial Nerve; D016896:Treatment Outcome
chemical_list: D013973:Thyrotropin-Releasing Hormone