title: Structure-antifilarial activity relationship of 5/6/7/8-mono- or disubstituted 1H/1-phenyl-9H-pyrido[3,4-b]indoles--a new class of potential filaricides.
abstract: Antifilarial activity of 5/6/7/8-mono- or disubstituted 1 H/1-phenyl-9H-pyrido[3,4-b]indoles (I) has been described. The 1,6- and 8-substituted 9H-pyrido[3,4-b]indoles (I) elicited interesting filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae in rodent hosts.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
authors.forename: S K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: S N
authors.initials: SN
authors.lastname: Singh
authors.forename: N
authors.initials: N
authors.lastname: Fatma
authors.forename: R K
authors.initials: RK
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D004153:Dipetalonema / Q000187:drug effects*; D005369:Filaricides / Q000737:chemistry / Q000494:pharmacology*; D005370:Filarioidea / Q000187:drug effects*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009115:Muridae; D016205:Sigmodontinae; D013329:Structure-Activity Relationship
chemical_list: D005369:Filaricides; D007211:Indoles