[Effects of T4 monomer of Tripterygium wilfordii and artificial musk on experimental allergic neuritis].
Both T4 monomer of Tripterygium wilfordii and artificial musk had effects in regulating immune system and anti-inflammation. The effect of using artificial musk was the earlier the stronger. According to pharmacological features of the two drugs and pathogenesis of experimental allergic neuritis (EAN), 5 experimental groups were established, i.e., artificial musk prevented and treated groups, dexamethasone and T4 monomer treated groups, and control group.


RESULTS
T4 monomer could reduce the clinical score of model rabbits of EAN and significantly ameliorated inflammatory cell infiltration and demyelination. It was similar to dexamethasone. Although artificial musk had mild preventing and treating effects on the clinical and pathological changes of EAN, but was not statistically significant in comparing with control group. Our clinical or pathological data suggested that T4 monomer and dexamethasone were effective in the treatment of EAN, and that of artificial musk in preventing and treating EAN as indefinite.
Wang
C D
CD
Dept. of Neurology, Beijing Hospital.
Guo
Y P
YP
D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D011817:Rabbits; D012584:Sciatic Nerve / Q000473:pathology; D029757:Tripterygium
D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D008419:Materia Medica; D003907:Dexamethasone