title: Persistent polyclonal B-cell lymphocytosis.
abstract: We document a case of persistent lymphocytosis in which the characteristic binucleated circulating lymphocytes were shown immunologically to be polyclonal B-cells. Cytogenetic and molecular studies failed to show a clonal population. A review of the literature on this rare condition, persistent polyclonal B-cell lymphocytosis, highlights an association with the female sex, HLA-DR7 antigen, smoking and raised levels of IgM, all of which were present in our patient.
authors.affiliation: Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Agrawal
authors.forename: E
authors.initials: E
authors.lastname: Matutes
authors.forename: J
authors.initials: J
authors.lastname: Voke
authors.forename: M J
authors.initials: MJ
authors.lastname: Dyer
authors.forename: T
authors.initials: T
authors.lastname: Khokhar
authors.forename: D
authors.initials: D
authors.lastname: Catovsky
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008218:Lymphocytosis / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged