[An experimental study of the effect of Acanthopanax giraldii Harms on the central nervous system].
Experimental data indicated that Acanthopanax giraldii given intraperitoneally in mice had pronounced inhibitory effects on the CNS. It reduced the spontaneous activity, prolonged the hypnotic time of pentobarbital sodium and antagonised the amphetamine-induced hyperactivity. The results suggest that the sedative effect of A. giraldii is probably different from that of diazepam, but perhaps similar to that of reserpine.
Deng
H Z
HZ
Nanfang Hospital of No 1 Military Medical University, Guangzhou.
Hou
L B
LB
Sun
S Y
SY
Li
S Y
SY
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000187:drug effects
D014151:Anti-Anxiety Agents; D004365:Drugs, Chinese Herbal; D012701:Serotonin; D000661:Amphetamine