Expansion and activation of human natural killer cells for autologous therapy.
Ex vivo depletion of lymphocytes has been used to decrease the incidence of acute graft-versus-host disease following the allogeneic bone marrow transplantation. Many depletion techniques also remove natural killer (NK) cells that may mediate a beneficial graft-versus-leukemia effect. In this paper we review our studies on ex vivo expansion and activation of NK cells for use in the therapy of chronic myelogenous leukemia.
Miller
J S
JS
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455.
Verfaillie
C
C
McGlave
P
P
D016026:Bone Marrow Transplantation / Q000379:methods*; D002986:Clinical Trials as Topic; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008213:Lymphocyte Activation; D014182:Transplantation, Autologous