DNA-protein interactions. Flip out and modify.
The crystal structure of a complex between a methyltransferase and DNA shows that, remarkably, the target cytosine base is swung out of the double helix and located next to the enzyme's S-adenosyl-L-homocysteine cofactor.
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European Molecular Biology Laboratory, Heidelberg, Germany.
D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D004269:DNA, Bacterial / Q000737:chemistry / Q000378:metabolism; D015257:DNA-Cytosine Methylases / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*; D012436:S-Adenosylmethionine / Q000378:metabolism
D004269:DNA, Bacterial; D011506:Proteins; D012436:S-Adenosylmethionine; D004247:DNA; C037664:DNA modification methylase HhaI; D015257:DNA-Cytosine Methylases