title: Primary cutaneous plasmacytosis: report of three cases and review of the literature.
abstract: BACKGROUND
  Cutaneous plasmacytosis is a rare disease characterized by peculiar multiple eruptions and hypergammaglobulinemia. More than 40 cases have been reported, mainly in Japan, although information concerning the disorder was limited to individual case reports.
  
  
  OBJECTIVE
  To clarify the clinicopathological and laboratory features, we reviewed 41 cases.
  
  
  RESULTS
  All patients were Japanese and the male-to-female ratio was 1:0.6. The onset ages ranged from 20 to 62 years, with a mean and median of 37 and 37 years. A superficial lymphadenopathy was detected in 58% (22/38), and polyclonal hypergammaglobulinemia was found in 93% (38/41). No cases were associated with any apparent underlying diseases. The course was chronic without spontaneous remission. Four patients died, 3 of whom succumbed to leukemia, respiratory failure or renal failure, respectively.
  
  
  CONCLUSIONS
  The results suggest that the condition appears to be a variant of reactive plasmacytic disorders of unknown origin.
authors.affiliation: Department of Dermatology, School of Medicine, Shinshu University, Matsumoto, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Uhara
authors.forename: T
authors.initials: T
authors.lastname: Saida
authors.forename: S
authors.initials: S
authors.lastname: Ikegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Mikoshiba
authors.forename: S
authors.initials: S
authors.lastname: Nijoh
authors.forename: K
authors.initials: K
authors.lastname: Kitano
authors.forename: C S
authors.initials: CS
authors.lastname: Koh
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology*