title: The insular claustrum in the methylazoxymethanol acetate (MAM) treated rats shows two different populations of neurons.
abstract: Methylazoxymethanol acetate (MAM) is a substance that inhibits migration of neurons in the embryonic brain. After intraperitoneal injection of two different doses of MAM to pregnant rats, microcephaly with or without complete development of the cerebral cortex was observed in every litter. High MAM doses (30 mg/kg) resulted in the lack of superficial layers (II-IV) of the cerebral cortex when the deep layers (V, VI) were seen. The claustrum was present but composed of loosely packed, medium-size, triangular or fusiform neurons with anarchic oriented long axes. After administration of low MAM doses (14 mg/kg) two different parts (medial and lateral) of the insular claustrum were observed. Our results suggest that neurons of the insular claustrum create two different subpopulations of cells, which were similar to that observed in primitive insectivore (e.g., hedgehog), but fuse in development.
authors.affiliation: Department of Anatomy, School of Medicine, Gdańsk, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Moryś
authors.forename: M
authors.initials: M
authors.lastname: Bobiński
authors.forename: B
authors.initials: B
authors.lastname: Maciejewska
authors.forename: B
authors.initials: B
authors.lastname: Berdel
authors.forename: P B
authors.initials: PB
authors.lastname: Kozłowski
authors.forename: M
authors.initials: M
authors.lastname: Dambska
authors.forename: H M
authors.initials: HM
authors.lastname: Wisniewski
authors.forename: O
authors.initials: O
authors.lastname: Narkiewicz
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000473:pathology; D005260:Female; D008746:Methylazoxymethanol Acetate / Q000494:pharmacology*; D008831:Microcephaly / Q000139:chemically induced; D009474:Neurons / Q000187:drug effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008746:Methylazoxymethanol Acetate