Dose-dependent effects of zinc supplementation during chelation of lead in rats.
Dose-dependent effects of zinc supplementation in order to enhance the efficacy of calcium disodium EDTA in lead intoxicated rats was investigated in rats. The results suggest simultaneous supplementation of zinc at a lower concentration i.e. 10 mg/kg (orally, once during chelation treatment), 25 mg/kg zinc (Flora & Tandon 1990) potentiates the mobilization of lead from blood and soft tissues. However, at a higher dose level (50 mg/kg once orally) it has deleterious and much reduced ability to deplete tissue lead contents and restore altered lead sensitive biochemical variables.
Flora
S J
SJ
Defence Research and Development Establishment, Division of Pharmacology and Toxicology, Gwalior, India.
Bhattacharya
R
R
Sachan
S R
SR
D000818:Animals; D001774:Blood Chemical Analysis; D001921:Brain / Q000378:metabolism; D015913:Chelation Therapy; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000627:therapeutic use*; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000378:metabolism*; D007855:Lead Poisoning / Q000188:drug therapy*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology*
D007854:Lead; D004492:Edetic Acid; D015032:Zinc