Synthesis of substituted [1]benzothieno[2,3-b]pyrazines and their ability to antagonize KCl induced contractions.
A series of substituted [1]benzothieno [2,3-b]pyrazines, structurally related to caroverine, was synthesized. Some of these compounds showed an appreciable inhibition towards KCl induced contractions on isolated rat aortic rings, and a lower potency towards negative inotropic activity tested on isolated guinea pig atrium.
Guerrera
F
F
Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italy.
Salerno
L
L
Sarvà
M C
MC
Siracusa
M A
MA
Rescifina
A
A
Scalia
R
R
Bianchi
A
A
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D011189:Potassium Chloride / Q000494:pharmacology; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects*
D002121:Calcium Channel Blockers; D011719:Pyrazines; D011810:Quinoxalines; D011189:Potassium Chloride; C000957:caroverine