title: [Hypercalcitoninemia and disorders of dentition development. A family study].
abstract: BACKGROUND
  A lot of factors interfere in the physiopathology of the exfoliation of the primary teeth. One of the most important factors is bone shuffle which is due to osteoclastic activity; this activity is controlled by a hormonal equilibrium.
  
  
  METHODS
  The aim of the present study was to correlate primary teeth's exfoliation delay in two brothers with their hypercalcitoninemia. They had a positive familiar anamnesis for thyroid medullar cancer; this disease is notoriously associated with hypercalcitoninemia.
  
  
  CONCLUSIONS
  The connection between a high basal and after-stimulation seric level of calcitonin and a lower activity of osteoclasis is evident. Thus, i also appeared evident to us the connection between the hormonal disease of the two children and the delay of exfoliation of their primary teeth. In these cases, it is important to control periodically the patients in order to prevent or to diagnose early isolated medullar thyroid cancer or a multiple endocrine adenomatosis.
authors.affiliation: Servizio di Odontostomatologia, USL 9, Ospedale Misericordia e Dolce, Prato, Firenze.
authors.forename: A
authors.initials: A
authors.lastname: Marchesi
authors.forename: R
authors.initials: R
authors.lastname: Leoni
authors.forename: E
authors.initials: E
authors.lastname: Ricca
mesh_terms: D000293:Adolescent; D002116:Calcitonin / Q000097:blood*; D018276:Carcinoma, Medullary / Q000097:blood / Q000150:complications / Q000235:genetics; D002648:Child; D003818:Dentition, Mixed; D005260:Female; D006801:Humans; D008297:Male; D010418:Pentagastrin; D011862:Radiography, Panoramic; D013964:Thyroid Neoplasms / Q000097:blood / Q000150:complications / Q000235:genetics; D013997:Time Factors; D014078:Tooth Eruption
chemical_list: D002116:Calcitonin; D010418:Pentagastrin
vernacular_title: Ipercalcitoninemia e disturbi della permuta dentale. Studio su un nucleo familiare.