Anti-idiotype antibodies and circulating immune complexes after immunisation with tetanus-toxoid.
OBJECTIVE
To determine if anti-idiotype antibodies and circulating immune complexes in individuals before and after immunisation with tetanus toxoid play a role in the immune response.


METHODS
A study of individuals who were administered a single dose of tetanus toxoid (TT) and who were unimmunized.


METHODS
Out patient departments of a large public hospital in Bombay, India.


METHODS
Thirty eight individuals pre-immunisation and forty five individuals post-immunisation with tetanus toxoid, tested at 1, 3, 6, and 12 months.


METHODS
Development of anti-tetanus anti-idiotype antibodies and circulating immune complexes.


RESULTS
Pre-immunisation cases did show presence of anti-tetanus antibodies but in lower titres than post-immunisation up to six months, after which there was a reduction. Specific anti-idiotype antibodies were detected in 19 cases. One and three months after immunisation more cases had high titre antibodies and circulating immune complexes, though after six months, there was a fall in anti-tetanus antibody titres. Circulating immune complexes were seen in those samples having anti-idiotype antibodies.


CONCLUSIONS
Though a significant rise in anti-tetanus antibody anti-idiotype antibodies, protective levels in mice and circulating immune complexes are seen after immunisation with TT it lasts for six months. When followed up for a period of one year it is observed that in cases having auto anti-idiotype antibodies, the anti-tetanus antibodies are maintained for a longer period.
Kamath
P S
PS
Blood Bank KEM Hospital, Poona.
Badakere
S S
SS
Mehta
B C
BC
D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000187:drug effects* / Q000276:immunology; D000907:Antibodies, Bacterial / Q000097:blood / Q000187:drug effects / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000097:blood / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood / Q000187:drug effects / Q000276:immunology; D013745:Tetanus Toxoid / Q000494:pharmacology*
D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D013745:Tetanus Toxoid