title: Ultrastructure of fibrillar granules in human neutrophils.
abstract: Fibrillar granules (FGs) represent neutrophilic primary granules containing clustered filaments. We investigated neutrophils in the bone marrow obtained from 17 patients with chronic myeloproliferative disorders (CMPD) by electron microscopy. FG-positive neutrophils were seen in 15 of the 17 CMPDs with varying frequencies. The diameter of FG-filaments was 7-8 nm, showing that they corresponded to neither intermediate filaments nor actin filaments.
authors.affiliation: Third Department of Internal Medicine, Asahikawa Medical College, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takemori
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: R
authors.initials: R
authors.lastname: Onodera
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Miyokawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology / Q000648:ultrastructure*