title: A comparison of timolol maleate and levobunolol. Length of use per 5-ml bottle.
abstract: OBJECTIVE
  The authors analyzed the actual length of use of commercially available 5-ml bottles of 0.5% timolol maleate (Timoptic) and 0.5% levobunolol (Betagan) among patients who routinely use topical beta-blockers (1 drop twice daily in both eyes) for glaucoma treatment.
  
  
  METHODS
  Patients were randomized to receive two 5-ml bottles of either timolol or levobunolol in a double-blind fashion. The patients used the drops independently and the bottles in sequence. The dates were recorded when each of the two 5-ml bottles were used. Sixty patients were enrolled, 15 were excluded from the study, and the data from the remaining 45 were analyzed.
  
  
  RESULTS
  There was a 21% greater length of use per 5-ml bottle among patients who were randomized to 0.5% timolol maleate (36.6 +/- 10.4 days) compared with 0.5% levobunolol (28.9 +/- 8.1 days) (P = 0.009). The length of use of the first bottle versus the second bottle was compared and was found not to be significantly different in either group. There was no statistical difference in intraocular pressure control among patients before and after the study.
  
  
  CONCLUSIONS
  There is a markedly greater length of use of the 5-ml bottle of timolol compared with the 5-ml bottle of levobunolol. The difference is believed to be due to the configuration of the levobunolol's bottle tip and the vehicle used to deliver the drug. The data may be extrapolated to a substantial patient savings and should be considered in prescription recommendations.
authors.affiliation: Department of Ophthalmology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois.
authors.forename: M A
authors.initials: MA
authors.lastname: Meyer
authors.forename: M L
authors.initials: ML
authors.lastname: Savitt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D016903:Drug Monitoring; D004349:Drug Packaging; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D002040:Levobunolol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy*; D009883:Ophthalmic Solutions; D013999:Timolol / Q000627:therapeutic use*
chemical_list: D009883:Ophthalmic Solutions; D013999:Timolol; D002040:Levobunolol