title: Risk factors for genital papillomavirus infection in populations at high and low risk for cervical cancer.
abstract: This study sought to determine risk factors for genital infection with papillomavirus (HPV) in Panamanian women 20-49 years old. Subjects were randomly selected from Herrera and Panama provinces (cervical cancer incidence 79 and 25/100,000, respectively). Participants were interviewed to determine sexual behavior. Cervicovaginal lavage specimens were obtained to test for HPV DNA by commercial dot blot hybridization. HPV-16/18 DNA was detected significantly more frequently (5%) in Panama than Herrera (2%) samples (P = .002). Clearly, infection with high-risk HPV types alone cannot account for the differences in cervical cancer incidence between the two populations. HPV-16/18 detection decreased with increasing years of sexual experience among all women in Panama and among women with multiple partners in Herrera. However, HPV-16/18 detection did not change with sexual experience among monogamous women in Herrera. Thus, the epidemiology of HPV is complex and reflects both virus- and population-specific factors.
authors.affiliation: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
authors.forename: W C
authors.initials: WC
authors.lastname: Reeves
authors.forename: H E
authors.initials: HE
authors.lastname: Gary
authors.forename: P R
authors.initials: PR
authors.lastname: Johnson
authors.forename: J P
authors.initials: JP
authors.lastname: Icenogle
authors.forename: M M
authors.initials: MM
authors.lastname: Brenes
authors.forename: R M
authors.initials: RM
authors.lastname: de Britton
authors.forename: J G
authors.initials: JG
authors.lastname: Dobbins
authors.forename: D S
authors.initials: DS
authors.lastname: Schmid
mesh_terms: D000328:Adult; D000367:Age Factors; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005831:Genital Diseases, Female / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D006801:Humans; D008875:Middle Aged; D010176:Panama / Q000453:epidemiology; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology; D011897:Random Allocation; D012307:Risk Factors; D012423:Rural Health / Q000706:statistics & numerical data; D012725:Sexual Behavior; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000473:pathology; D014504:Urban Health / Q000706:statistics & numerical data; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology
chemical_list: D004279:DNA, Viral