[Comparative pharmacokinetics of antibiotics in blood, csf and brain].
The Knowledge of the antibiotic's cerebral diffusion is essential to define a of neurosurgical antibioprophylaxis' strategy. Without references in the medical world-literature, we've decided to compare the pharmacological kinetics in the blood, the cerebrospinal fluid and the sound cerebral tissue of common used molecules in neurosurgery that is to say: amoxicillin, cefamandole, metronidazole and pefloxacin. The results show that the cerebral levels of metronidazole and pefloxacine are rapidly high with an extended duration (> 10 times the M.I.C. of the sensitive bacteriae), but the tissue penetration of amoxicillin is hazardous and shot-duration for cefamandole (undosable after 3 hours).
Redondo
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A
Service de Neurochirurgie, Hôpital Beaujon, Clichy.
Tessier
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C
Branger
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C
Rey
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A
D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000493:pharmacokinetics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001769:Blood / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000601:surgery; D002435:Cefamandole / Q000493:pharmacokinetics / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000493:pharmacokinetics / Q000627:therapeutic use; D008875:Middle Aged; D015366:Pefloxacin / Q000493:pharmacokinetics / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D015366:Pefloxacin; D002435:Cefamandole; D000658:Amoxicillin
Pharmacocinétique comparée d'antibiotiques dans le sang, le L.C.R. et le cerveau.