The cytotoxic T-lymphocyte response in HIV-1 infection.
HIV infection is associated with an extremely vigorous virus-specific cytotoxic T-lymphocyte (CTL) response. This CTL activity is of sufficient magnitude to be detected using freshly isolated peripheral blood mononuclear cells, but despite this vigorous immune response, HIV-1 disease ultimately progresses. This article describes methods used to detect CTL responses and epitopes recognized by HIV-1 specific CTL. The potential role of CTL in the control of viral replication, disease pathogenesis, and possible mechanisms that allow HIV-1 to ultimately evade the host's immune response is discussed. Finally, efforts to induce CTL responses through vaccines are summarized.
Kalams
S A
SA
Massachusetts General Hospital Infectious Disease Unit, Boston.
Walker
B D
BD
D016915:AIDS Vaccines / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology
D016915:AIDS Vaccines; D000956:Antigens, Viral; D014764:Viral Proteins