Pathobiology of focal sclerosis.
This paper briefly reviews recent experimental data derived from work in animals and cell cultures that have increased our understanding of the pathobiologic pathways leading to focal sclerosis. These pathways include glomerular visceral epithelial cell damage, leukocyte infiltration, hyperplasia and matrix accumulation in the mesangium, and endothelial injury.
Wolthuis
A
A
Department of Pathology, University of Groningen, The Netherlands.
van Goor
H
H
Weening
J J
JJ
Grond
J
J
D000818:Animals; D005923:Glomerulosclerosis, Focal Segmental / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000503:physiopathology