The influence of captopril and naloxone on the Valsalva manoeuvre and systolic time intervals in healthy volunteers.
1. The aim of the study was to ascertain whether the inhibition of the sympathetic nervous system by angiotensin-converting enzyme (ACE) inhibitors is mediated by endogenous opioids. Naloxone was used to evaluate the effects of the latter on systolic time intervals (STI) and Valsalva manoeuvre-induced blood pressure and heart rate changes. 2. Baseline recordings were done in 12 healthy male volunteers and repeated 2 h after oral administration of 75 mg of captopril and again after naloxone 0.4 mg/kg was administered intravenously over 10 min. 3. After captopril there was a significant reduction in systolic (P < 0.02) and mean blood pressure (P < 0.04) without any changes in heart rate. Furthermore, captopril increased the Valsalva ratio (P < 0.06) but did not influence inotropism as indicated by STI. Naloxone did not influence any of these findings. 4. The changes in the Valsalva ratio after captopril were mediated by an increase in the maximum bradycardia in nine of the 12 subjects. 5. The results indicate that endogenous opioids do not play a role in the putative sympatholytic effect of ACE inhibition.
Richter
J P
JP
Department of Pharmacology, University of Pretoria, Republic of South Africa.
Sommers
D K
DK
Snyman
J R
JR
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004745:Enkephalins / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology*; D012016:Reference Values; D013599:Systole / Q000187:drug effects / Q000502:physiology*; D014636:Valsalva Maneuver / Q000502:physiology*
D004745:Enkephalins; D009270:Naloxone; D002216:Captopril