title: Natural history of HIV infection in Filipino female commercial sex workers.
abstract: A prospective follow-up study of the progression of HIV infection, from seroconversion to onset of opportunistic infections (OI) indicative of immune deficiency and to death, was performed in a cohort of 54 HIV-1 antibody positive Filipino female commercial sex workers (FCSW). The cumulative probability of having a CD4+ T cell count of < 200/mm3 and/or an OI indicative of severe immune deficiency was 52.9% within 5 years and 73.8% within 6 years after seroconversion. The cumulative probability of death was 52.1% within 6.5 years following seroconversion and 52.7% within 1.5 years after a depressed (< 200/mm3) CD4+ T cell or onset of an OI. Although several OI associated with immune impairment were observed, a CD4+ cell count of < 200/mm3 was the initial indicator of a failing immune system in more than 50% of the patients. Mycobacterium tuberculosis or unidentified acid fast bacilli (presumed to be M. tuberculosis) and Pneumocystis carinii pneumonia were the initial indicators of immune deficiency in the remaining patients.
authors.affiliation: U.S. Naval Medical Research Unit No. 2 Detachment, Manila, Philippines.
authors.forename: C R
authors.initials: CR
authors.lastname: Manaloto
authors.forename: J G
authors.initials: JG
authors.lastname: Perrault
authors.forename: L T
authors.initials: LT
authors.lastname: Caringal
authors.forename: E G
authors.initials: EG
authors.lastname: Santiago
authors.forename: F S
authors.initials: FS
authors.lastname: Wignall
authors.forename: V L
authors.initials: VL
authors.lastname: Gonzales
authors.forename: R L
authors.initials: RL
authors.lastname: Anthony
authors.forename: C G
authors.initials: CG
authors.lastname: Hayes
mesh_terms: D000386:AIDS-Related Complex / Q000209:etiology; D017088:AIDS-Related Opportunistic Infections / Q000209:etiology; D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000209:etiology* / Q000276:immunology; D006801:Humans; D017733:Leukoplakia, Hairy / Q000209:etiology; D010679:Philippines; D011336:Probability; D011446:Prospective Studies; D011477:Sex Work; D013997:Time Factors