title: Denervation atrophy in three horses with fibrotic myopathy.
abstract: Three horses with fibrotic myopathy were examined for neuromuscular disease. In 2 horses, concentric needle electromyography was performed. Dense spontaneous activity suggestive of denervation, was found in multiple thigh muscles of 1 of the 2 horses. All 3 horses were euthanatized. Histochemical and histologic examination of tissue specimens was performed. All horses had degenerative lesions in peripheral and intramuscular nerves. Angular atrophy of type-1 and type-2 muscle fibers, indicative of denervation atrophy, was seen in multiple muscle specimens from all 3 horses. One horse was found to have a fracture of the greater trochanter, with fibrous entrapment of the sciatic nerve at that site. The cause of the peripheral neuropathy was not determined in the other 2 horses. It was concluded that peripheral neuropathy should be considered in horses with fibrotic myopathy.
authors.affiliation: Department of Pathology, College of Veterinary Medcine, Cornell University, Ithaca, NY 14853-6401.
authors.forename: B A
authors.initials: BA
authors.lastname: Valentine
authors.forename: S D
authors.initials: SD
authors.lastname: Rousselle
authors.forename: A E
authors.initials: AE
authors.lastname: Sams
authors.lastname: Edwards RB 3drd
mesh_terms: D000818:Animals; D004576:Electromyography / Q000662:veterinary; D005260:Female; D005355:Fibrosis; D006734:Horse Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006736:Horses; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology* / Q000503:physiopathology; D009133:Muscular Atrophy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D009410:Nerve Degeneration; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000662:veterinary*