title: [The diagnosis of Cushing's disease by the nocturnal dexamethasone administration test].
abstract: Prospective study performed at the General Hospital, National Medical Center, XXI Century, Endocrinology Ward, Mexico-City, to compare the diagnostic sensitivity in Cushing's disease of the oral high doses (8 mg) dexametazone suppression test in single doses with nocturnal administration (DXM-N) and the classic doses of two days (DXM-C). Fourteen patients with hypercortisolism were studied; on thirteen the hypophyseal origin was surgical confirmed. Sensitivity of high doses of oral dexametazone test was proved by using serial samples of serum cortisol; the Fisher test was used for analysis of the suppression of serum cortisol after the test was done.
authors.affiliation: Hospital de Cardiología, Centro Médico Nacional Siglo XXI, México, D.F.
authors.forename: C
authors.initials: C
authors.lastname: Vázquez Chávez
authors.forename: R
authors.initials: R
authors.lastname: Miranda Ruíz
authors.forename: K
authors.initials: K
authors.lastname: Acevedo Rivera
authors.forename: G R
authors.initials: GR
authors.lastname: Velasco y Aranzolo
authors.forename: O R
authors.initials: OR
authors.lastname: Brito Zurita
authors.forename: B
authors.initials: B
authors.lastname: López Félix
mesh_terms: D000293:Adolescent; D000308:Adrenocortical Hyperfunction / Q000175:diagnosis / Q000378:metabolism; D000328:Adult; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000378:metabolism; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D008297:Male; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D003907:Dexamethasone; D006854:Hydrocortisone
vernacular_title: Diagnóstico de la enfermedad de Cushing mediante la prueba de administración nocturna de dexametasona.