title: Pharmacokinetic results on naproxen prodrugs based on poly(ethyleneglycol)s.
abstract: Five prodrugs of S(+)-2-(6-methoxy-2-naphthyl)propionic acid (naproxen), in which the drug was bound by ester linkages to diethyleneglycol (I), triethyleneglycol (II), octanediol (III), butyl-triethyleneglycol (IV), and butyl-tetraethyleneglycol (V), respectively, were prepared and tested for their pharmacokinetic properties after oral administration. It was found that bioavailabilities decreased in the order, and in all cases were lower than that of the free drug.
authors.affiliation: Dipartimento di Ingegneria Meccanica, Università di Brescia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Ranucci
authors.forename: L
authors.initials: L
authors.lastname: Sartore
authors.forename: I
authors.initials: I
authors.lastname: Peroni
authors.forename: R
authors.initials: R
authors.lastname: Latini
authors.forename: R
authors.initials: R
authors.lastname: Bernasconi
authors.forename: P
authors.initials: P
authors.lastname: Ferruti
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers; D008297:Male; D015394:Molecular Structure; D009288:Naproxen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols; D011355:Prodrugs / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D004337:Drug Carriers; D011355:Prodrugs; D011092:Polyethylene Glycols; D009288:Naproxen