title: Cross-reactivity of monovalent and polyvalent Trimeresurus antivenoms with venoms from various species of Trimeresurus (lance-headed pit viper) snake.
abstract: Trimeresurus bite is a serious medical problem in Asia. However, at present only a few monospecific Trimeresurus antivenoms are available. Investigation of the cross-neutralization capacity of three Trimeresurus antivenoms indicates that the antivenoms exhibit broad cross-reactivity. A polyvalent Trimeresurus antivenom was also found to be effective in neutralization of the haemorrhagic, necrotizing and thrombin-like activities of heterologous Trimeresurus venoms.
authors.affiliation: Department of Biochemistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: N H
authors.initials: NH
authors.lastname: Tan
authors.forename: S K
authors.initials: SK
authors.lastname: Choy
authors.forename: K M
authors.initials: KM
authors.lastname: Chin
authors.forename: G
authors.initials: G
authors.lastname: Ponnudurai
mesh_terms: D000818:Animals; D000997:Antivenins / Q000276:immunology*; D003429:Cross Reactions; D003435:Crotalid Venoms / Q000276:immunology*; D013045:Species Specificity; D017841:Trimeresurus / Q000276:immunology*
chemical_list: D000997:Antivenins; D003435:Crotalid Venoms; C029748:Trimeresurus venoms