title: Comparison of the IgG subclass distribution of anti-thyroid peroxidase antibodies in healthy subjects with that in patients with chronic thyroiditis.
abstract: The IgG subclass distribution of anti-thyroid peroxidase (TPO) antibodies in patients with chronic thyroiditis and in healthy subjects has been investigated. Anti-TPO antibodies in sera of patients with chronic thyroiditis were predominantly associated with IgG1, with a lesser contribution by IgG4 and IgG3. In contrast, anti-TPO antibodies of healthy subjects were exclusively associated with IgG4. Since structural differences in IgG subclasses reflect differences in their biological roles, these findings suggest that the role of anti-TPO antibodies in patients may differ from that in healthy subjects.
authors.affiliation: Department of Pediatrics, School of Medicine, Chiba University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kohno
authors.forename: M
authors.initials: M
authors.lastname: Kijima
authors.forename: F
authors.initials: F
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Tsunoo
authors.forename: T
authors.initials: T
authors.lastname: Hosoya
authors.forename: H
authors.initials: H
authors.lastname: Niimi
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification* / Q000276:immunology; D007453:Iodide Peroxidase / Q000276:immunology*; D008297:Male; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000276:immunology*
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D007453:Iodide Peroxidase