[The first homotopic fetal homograft of the striatum in the treatment of Huntington's disease].
Fetal brain grafting has been used successfully in the restoration of striatal function in rat and non human primate models of Huntington's disease (HD). This is a report of the first clinical trial of this procedure applied to a 37 year old Mexican female with moderate to severe HD of 9 years evolution. The two striata from a 13 week-old human fetus were homotopically transplanted to 4 cavities in the ventricular wall of the right caudate nucleus. The months after surgery, her neurologic and neuropsychologic evaluations revealed the stabilization of many of her signs and most neuropsychologic parameters, a moderate improvement of her choreic movements, predominantly in the face, of her ability to define and express ideas in oral and written form, and of her articulatory agility, as well as of some activities of her daily life and social behavior. There was a slight deterioration of her gait and posture. Her saccadic system and optokinetic nystagmus, and her visuospatial and visuoperceptual functions were deteriorated.
Madrazo
I
I
Unidad de Investigación Clínica en Neurología y Neurocirugía, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México, D.F.
Cuevas
C
C
Castrejon
H
H
Guizar-Sahagun
G
G
Franco-Bourland
R E
RE
Ostrosky-Solis
F
F
Aguilera
M
M
Magallon
E
E
D000328:Adult; D016380:Brain Tissue Transplantation; D003342:Corpus Striatum / Q000637:transplantation*; D005260:Female; D016332:Fetal Tissue Transplantation; D005500:Follow-Up Studies; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology / Q000601:surgery*; D009460:Neurologic Examination; D011247:Pregnancy; D011581:Psychological Tests
Primer homotrasplante fetal homotópico de estriado para el tratamiento de la enfermedad de Huntington.