Helicobacter pylori an chronic atrophic gastritis.
Phenol red dye spraying endoscopy, in addition to a biopsy study, was employed for the determination of Helicobacter pylori distribution on the gastric mucosa of 108 patients with no gross gastric findings. The sensitivity of this method was 100%, and its specificity was 84.6%. In patients with a C0 pattern of the fundic-pyloric (F-P) border, the H. pylori-positive rate was only 21%, but this increased with the spread of atrophic mucosa, to approximately 90%. However, in patients with an O3 pattern, H. pylori could not be found. In addition, in 24 (80.0%) of 30 patients with no glandular atrophy, this organism was not found, while, in contrast, the organism was demonstrated in 54 (85.8%) of 63 patients with a slight degree of glandular atrophy. In patients with severe mucosal atrophy accompanying intestinal metaplasia, however, the organism was not found. One-half of the patients examined were followed up, using this technique. In those who were H. pylori-negative, glandular atrophy remained unchanged, while advanced glandular atrophy was seen in 10 (28.6%) of 35 H. pylori-positive patients. A cephalad shift of the F-P border was observed in 20 (57.1%) of these 35 H. pylori-positive patients, while in those who were negative, the F-P border remained unchanged, with one exception.
Kohli
Y
Y
Second Department of Internal Medicine, Fukui Medical School, Japan.
Kato
T
T
Ito
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D005748:Gastric Fundus; D005753:Gastric Mucosa / Q000382:microbiology; D005757:Gastritis, Atrophic / Q000382:microbiology*; D005773:Gastroscopy / Q000379:methods; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010637:Phenolsulfonphthalein; D011708:Pylorus; D012680:Sensitivity and Specificity
D010637:Phenolsulfonphthalein