title: Congenital toxoplasmosis in twins: a case report.
abstract: We report a case of congenital toxoplasmosis in a twin pregnancy at 21 weeks of gestation. The complete antenatal investigation included ultrasound examination, cordocentesis and amniocentesis. The ultrasonographic evaluation showed a distinct morphological aspect confirmed by the fetal biological profile. The time lag between placental and fetal infection, or the immunological fetal responses could explain the varying stages of the fetal disease. This is another case which early demonstrates that there may exist a distinct clinical pattern in bichorial pregnancy with varying biological fetal responses. It underlines the importance of cordocentesis in the case of maternal toxoplasma seroconversion, enabling us to gather a maximum number of biological data for complete appreciation of the fetal status. The information obtained permits a precise adaptation of the medical decision.
authors.affiliation: Service de Médecine foetale, CMCO, Schiltigheim, France.
authors.forename: R
authors.initials: R
authors.lastname: Favre
authors.forename: G
authors.initials: G
authors.lastname: Grangé
authors.forename: B
authors.initials: B
authors.lastname: Gasser
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000649:Amniocentesis; D017218:Cordocentesis; D004200:Diseases in Twins; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography