title: Growth curve for Propionibacterium acnes.
abstract: We established growth curves for Propionibacterium acnes isolates recovered from eyes with chronic postoperative endophthalmitis. The growth curve plotted the average of the duplicate bacterial concentration against time. The generation time for P. acnes calculated from the growth curves was approximately 5.1 hours. The growth of P. acnes is slower than other anaerobic bacteria. This may account for its delayed appearance in culture of ocular specimens. It may also explain treatment failure if the concentration of an antibiotic injected into the vitreous does not remain at an effective level during the critical replicative phase of the organism.
authors.affiliation: Section of Microbiology, Cleveland Clinic, OH.
authors.forename: G S
authors.initials: GS
authors.lastname: Hall
authors.forename: K
authors.initials: K
authors.lastname: Pratt-Rippin
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: J A
authors.initials: JA
authors.lastname: Washington
authors.forename: T J
authors.initials: TJ
authors.lastname: Roussel
authors.forename: D
authors.initials: D
authors.lastname: Miller
mesh_terms: D002387:Cataract Extraction / Q000009:adverse effects; D002455:Cell Division; D002908:Chronic Disease; D009877:Endophthalmitis / Q000382:microbiology / Q000601:surgery; D015818:Eye Infections, Bacterial / Q000382:microbiology; D006801:Humans; D008828:Microbiological Techniques; D011183:Postoperative Complications; D011425:Propionibacterium acnes / Q000254:growth & development* / Q000302:isolation & purification; D014822:Vitreous Body / Q000382:microbiology