[Determination of plasma endothelin-1 in aged patients with chronic obstructive pulmonary disease in its clinical significance].
The levels of plasma endothelin-1 (ET-1) were determined by radioimmunoassay in 25 aged healty men and 88 aged patients with chronic obstructive pulmonary disease (COPD) at different stages. The results showed that plasma ET-1 levels of stable patients with COPD did not significantly change, but it were significantly higher during attacks than that in healthy subjects; The levels of plasma ET-1 in the patients with cor pulmonale were significantly higher than those in the healthy and COPD patients. Plasma ET-1 levels of patients with cor pulmonale at acute exacerbation stage were the highest in all groups. It was demonstrated that ET-1 correlated negatively to PaO2 and PH and correlated positively to PaCO2 and blood creatinine. This study suggested that the elevation of ET-1 level may contribute to the pathophysiological changes in patients with COPD and cor pulmonale.
Feng
C S
CS
General Hospital of PLA, Beijing.
Huang
N Q
NQ
Zeng
Q
Q
D000368:Aged; D003404:Creatinine / Q000097:blood; D016232:Endothelins / Q000097:blood*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000097:blood; D011863:Radioimmunoassay
D016232:Endothelins; D003404:Creatinine