title: A cytogenetic study of 19 recurrent gliomas.
abstract: A cytogenetic analysis was performed on 19 recurrent gliomas all of which had been treated by radiotherapy. All cases exhibited clonal chromosomal anomalies, the tumors were classified into four categories in relation to their mono- or polyclonality and to the presence or absence of a clonal evolution. Polyclonal tumors without clonal evolution had a delay of recurrence significantly longer than monoclonal or polyclonal tumors with clonal evolution. This difference could be related to the presence of clones with different malignant potential, which could be differentiated by their pattern of chromosomal aberrations. The malignant potential of "highly malignant" clones resulted from the juxtaposition of imbalances, such as monosomy 10, as in high-grade primary gliomas, and presumably radiation-induced structural rearrangements. That of clones of low malignancy was almost limited to the presence of multiple balanced structural rearrangements, probably induced by radiation.
authors.affiliation: Laboratoire de Cytogénétique et Génétique, Fontenay-aux-Roses, France.
authors.forename: E
authors.initials: E
authors.lastname: Pruchon
authors.forename: L
authors.initials: L
authors.lastname: Chauveinc
authors.forename: L
authors.initials: L
authors.lastname: Sabatier
authors.forename: A M
authors.initials: AM
authors.lastname: Dutrillaux
authors.forename: M
authors.initials: M
authors.lastname: Ricoul
authors.forename: J Y
authors.initials: JY
authors.lastname: Delattre
authors.forename: F
authors.initials: F
authors.lastname: Vega
authors.forename: M
authors.initials: M
authors.lastname: Poisson
authors.forename: F
authors.initials: F
authors.lastname: Hor
authors.forename: B
authors.initials: B
authors.lastname: Dutrillaux
mesh_terms: D000293:Adolescent; D000328:Adult; D002999:Clone Cells; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology*