The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex.
The dose-response inhibitory effect of 8-OH-DPAT on the firing rate of dorsal raphe serotoninergic neurons was shifted 10-fold to the right after acute fronto-cortical deafferentation. This finding suggests that the inhibitory effect of 8-OH-DPAT on the dorsal raphe firing rate might be mediated indirectly by the frontal cortex.
Ceci
A
A
Department of Pharmacology, Boehringer Ingelheim Italia, Milan.
Baschirotto
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A
Borsini
F
F
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D005625:Frontal Lobe / Q000166:cytology / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011903:Raphe Nuclei / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000502:physiology*
D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin