[Erythema necroticans migrans without glucagonoma].
Necrolytic migratory erythema is considered to be one of five well-defined paraneoplastic syndromes of the skin. An association with a pancreatic A-cell glucagonoma is commonly postulated. However, during the last years 10 cases of necrolytic migratory erythema with no evidence for glucagonoma have been published. We report on a 59-year-old woman who presented with typical clinical and histological findings of necrolytic migratory erythema. Staging and laboratory investigations gave no evidence of any neoplasia. A liver biopsy revealed chronic persisting hepatitis. Hepatocellular dysfunction was recently reported to be present concomitantly in a number of cases of necrolytic migratory erythema, suggesting a relation to the skin changes described here.
Tanner
M
M
Hautklinik, Christian-Albrechts-Universität zu Kiel.
Brasch
J
J
Christophers
E
E
D001706:Biopsy; D004890:Erythema / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005935:Glucagonoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000175:diagnosis / Q000473:pathology; D008111:Liver Function Tests; D008875:Middle Aged; D009336:Necrosis; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology
Erythema necroticans migrans ohne Glukagonom.