title: Accuracy of radiology in detection of hepatocellular carcinoma before liver transplantation.
abstract: OBJECTIVE
  Recurrence of hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLT) depends on tumor size and number; the accuracy of radiology in detecting HCC is uncertain. This study compared tumor size at radiological and pathological examination in 30 patients with HCC who underwent OLT.
  
  
  METHODS
  Pre-OLT radiology included ultrasonography (US), computerized tomography (CT), and hepatic angiography (HA). Sensitivity of radiology was calculated by comparison with pathology.
  
  
  RESULTS
  Radiology missed HCC in two patients but showed five with small (< 4 cm) and eight with large (> 4 cm) lesions. Multicentricity was shown in 15 cases at radiological examination and 24 at pathological examination, including one incidental and 4 of 5 radiologically small HCC. Mean tumor bulk was 3.4, 74, 338, and 1375 cm3, respectively, in patients with incidental, small, large, and multicentric HCC at radiology. Sensitivities of US, CT, and HA in detection of HCC (and multicentricity) were 80% (16.6%), 86.6% (58.3%), and 90% (58.3%). No recurrence was found in patients with incidental or small HCC; even when multicentric.
  
  
  CONCLUSIONS
  US, CT, and HA identified patients with small or large tumor bulk, but sensitivity in detecting satellites was poor; their finding in patients with radiologically small or incidental tumors does not affect outcome. The failure of US, CT, and HA to detect satellites must be considered in patients undergoing partial hepatectomy for HCC.
authors.affiliation: Institute of Liver Studies, King's College Hospital, Denmark Hill, London, England.
authors.forename: P M
authors.initials: PM
authors.lastname: Rizzi
authors.forename: P A
authors.initials: PA
authors.lastname: Kane
authors.forename: S D
authors.initials: SD
authors.lastname: Ryder
authors.forename: J K
authors.initials: JK
authors.lastname: Ramage
authors.forename: E
authors.initials: E
authors.lastname: Gane
authors.forename: K C
authors.initials: KC
authors.lastname: Tan
authors.forename: B
authors.initials: B
authors.lastname: Portmann
authors.forename: J
authors.initials: J
authors.lastname: Karani
authors.forename: R
authors.initials: R
authors.lastname: Williams
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography