Neostriatal mosaic and type II Ca2+/calmodulin-dependent protein kinase: an immunohistochemical study on the adult rat striatum.
The present immunohistochemical study is concerned with the expression of type II Ca2+/calmodulin-dependent protein kinase (CaM-kinase II), which is supposed to play an essential role in the intracellular Ca2+ signal transduction, in the striatum of adult rats. CaM-kinase II immunoreactivity was differentially concentrated in irregularly shaped compartments within the nucleus in a mosaic-like fashion. The compartment of heightened CaM-kinase II-immunolabeling corresponded to the extrastriosomal matrix visualized by calbindin-D28k-immunostaining. Light microscopic observation showed neurons immunoreactive for CaM-kinase II to be less densely distributed in the striosomes than in the matrix compartment. The present data suggest that these two striatal compartments may differ in an intracellular Ca(2+)-signaling process associated with protein phosphorylation.
Goto
S
S
Department of Neurosurgery, Kumamoto University Medical School, Japan.
Yamada
K
K
Ushio
Y
Y
Fukunaga
K
K
Miyamoto
E
E
D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D017072:Neostriatum / Q000033:anatomy & histology / Q000166:cytology / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D064030:S100 Calcium Binding Protein G / Q000276:immunology / Q000378:metabolism
C576500:Calb1 protein, rat; D064092:Calbindin 1; D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D017871:Calcium-Calmodulin-Dependent Protein Kinases