Synthesis of new acyclic pyrimidine nucleoside analogs as potential antiviral drugs.
The synthesis of 6-[N-(4-hydroxybutyl)amino]pyrimidinone derivatives 18-23 and the acyclic phosphonate nucleoside analogs 29-30 is reported. Their cytotoxic and antiviral effects were investigated. 2,5-Diamino-6-[N-[2-(phosphonomethoxy)ethyl]amino]pyrimidin-4(3H)- one (30) showed strong antiviral effects, and 21 showed significant cytotoxic activity.
Eger
K
K
Universität Leipzig, Institut für Pharmazie, Germany.
Klünder
E M
EM
Schmidt
M
M
D000605:Amino Alcohols / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003198:Computer Simulation; D051379:Mice; D008956:Models, Chemical; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000605:Amino Alcohols; D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides; C089584:4-aminobutanol