Plasma angiotensin(1-7) immunoreactivity is increased by salt load, water deprivation, and hemorrhage.
In this study we investigated the effects of dehydration and hemorrhage on circulating levels of the heptapeptide, angiotensin(1-7). In water-deprived rats, a twofold increase in plasma angiotensin(1-7) was associated with similar increases in plasma renin activity, and angiotensin I and angiotensin II levels. In salt-loaded rats, plasma angiotensin(1-7) levels increased fourfold; however, other components of the renin-angiotensin system were suppressed or unchanged. In salt-loaded rats, increases in plasma angiotensin II levels in response to hemorrhage in normal rats were severely blunted, whereas angiotensin(1-7) plasma levels increased proportionately to the loss of blood volume. These results suggest that angiotensin(1-7) plasma concentration can be selectively regulated during dehydration and hemorrhage.
Botelho
L M
LM
Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Block
C H
CH
Khosla
M C
MC
Santos
R A
RA
D000803:Angiotensin I; D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D006470:Hemorrhage / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000009:adverse effects*; D014868:Water Deprivation / Q000502:physiology*; D014883:Water-Electrolyte Imbalance / Q000097:blood*
D010446:Peptide Fragments; D000804:Angiotensin II; D012965:Sodium Chloride; D000803:Angiotensin I; C118790:angiotensin I (1-7)