Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis.
A dehydrogenation polymer of ferulic acid (DHP-FA), a synthetic lignin, was evaluated for its ability to inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the 7,12-dimethylbenz[a]anthracene-treated skin of female ICR mice. Topical application of DHP-FA inhibits TPA-induced tumor promotion, whereas a monomeric ferulic acid does not show the inhibitory effect.
Asanoma
M
M
Nagoya City Public Health Research Institute, Japan.
Takahashi
K
K
Miyabe
M
M
Yamamoto
K
K
Yoshimi
N
N
Mori
H
H
Kawazoe
Y
Y
D015127:9,10-Dimethyl-1,2-benzanthracene; D000287:Administration, Topical; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D003043:Cocarcinogenesis; D003373:Coumaric Acids / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal; D011108:Polymers / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate
D016588:Anticarcinogenic Agents; D003373:Coumaric Acids; D011108:Polymers; D015127:9,10-Dimethyl-1,2-benzanthracene; C004999:ferulic acid; D013755:Tetradecanoylphorbol Acetate