Tumor induction in mice administered neonatally with N-bis(2-hydroxypropyl)nitrosamine (BHPN).
Two subcutaneous injections of N-bis(2-hydroxypropyl)nitrosamine (BHPN) to mice on day 1 and 8 induced tumors of the lung, liver, nasopharynx and pancreas, when animals were killed at the end of one year. The tumor incidences of lung were 90-100%; those of liver 60-92%; those of nasopharynx 3-13%; those of pancreas 2-3%, respectively. The average tumor nodules of lung and those of liver increased in a dose-dependent manner. Two doses of 50 mg/g body weight of BHPN induced one duct cell carcinoma and one acinar cell adenoma of pancreas in a mouse, respectively.
Fujii
K
K
Department of Pathology, University of Tsukuba, Ibaraki, Japan.
Hayakawa
T
T
Kikuchi
M
M
D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity*
D002273:Carcinogens; D009602:Nitrosamines; C037173:3-butenyl-(3-hydroxypropyl)nitrosamine