title: Fate of wheat bound malathion residues in rats during gestation.
abstract: Malathion [S-1,2-di(ethoxycarbonyl) ethyl 0,0-dimethyl phosphorodithioate], treated wheat when stored for 28 months at 20 degrees C with or without food grade white mineral oil on grains contained about 62 and 79% of the applied insecticide as bound residues, respectively. These bound residues were present mainly in the form of the parent compound. The stored wheat containing bound malathion residues, as well as wheat material freshly spiked with malathion were fed to rats during gestation. No residues of malathion and/or metabolites were detected in urine, feces and body tissues. Further no significant effect on body weight, serum chemistry and cytochrome P450 levels were observed in the mothers. There was no evidence for the histopathological alteration or teratogenic anomalies in the fetuses. However, placental transfer of malathion was indicated by the presence of the insecticide residues in fetuses from rats fed wheat material containing bound residues.
authors.affiliation: Centre for Land and Biological Resources Research, Argiculture Canada, Ottawa, Ontario.
authors.forename: G A
authors.initials: GA
authors.lastname: Bitsi
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: S U
authors.initials: SU
authors.lastname: Khan
authors.forename: M H
authors.initials: MH
authors.lastname: Akhtar
authors.forename: S
authors.initials: S
authors.lastname: Kacew
authors.forename: N D
authors.initials: ND
authors.lastname: White
mesh_terms: D000818:Animals; D001682:Biological Availability; D005260:Female; D005333:Fetus / Q000737:chemistry*; D005506:Food Contamination / Q000032:analysis; D008294:Malathion / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange; D010573:Pesticide Residues / Q000032:analysis / Q000493:pharmacokinetics*; D011247:Pregnancy; D051381:Rats; D014908:Triticum / Q000737:chemistry
chemical_list: D010573:Pesticide Residues; D008294:Malathion