title: Metastatic epithelioid sarcoma with an N-ras oncogene mutation.
abstract: At age 25 a Japanese woman noticed an elastic-hard nodule 2 cm in diameter on the anterior side of her right leg. The nodule had developed an ulcer in its center. Simple resection was performed several times. However, the lesion recurred repeatedly. The patient underwent amputation of the right leg at the age of 34, because the diagnosis of epithelioid sarcoma was established histologically. No recurrence was observed for 9 years. Recently, the patient noticed multiple painful, ulcerative nodules about 1 cm in diameter on her scalp, trunk, and extremities. She refused extensive resection for a religious reason and died of massive hematemesis. Autopsy revealed metastatic epithelioid sarcoma in the skin, lungs, kidneys, pancreas, transverse colon, thyroid, and sternum. Chromosomal analysis of the tumor revealed various aberrations and an N-ras oncogene mutation.
authors.affiliation: Department of Dermatology, Osaka Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kusakabe
authors.forename: K
authors.initials: K
authors.lastname: Yonebayashi
authors.forename: S
authors.initials: S
authors.lastname: Sakatani
authors.forename: M
authors.initials: M
authors.lastname: Iki
authors.forename: K
authors.initials: K
authors.lastname: Nakasuji
authors.forename: K
authors.initials: K
authors.lastname: Kiyokane
authors.forename: M
authors.initials: M
authors.lastname: Yasuhara
authors.forename: J
authors.initials: J
authors.lastname: Nakagawa
authors.forename: H
authors.initials: H
authors.lastname: Mori
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D017354:Point Mutation; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D012509:Sarcoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000556:secondary; D012878:Skin Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*
chemical_list: C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)