[Bacteriological and clinical studies of biapenem (L-627) in pediatric field].
We have carried out bacteriological and clinical studies on L-627. The results are summarized as follows. Treatment with L-627 was made in 14 cases of pediatric bacterial infections including 5 cases of pneumonia and 2 cases each of tonsillitis, urinary tract infection and one case each of colitis, and phlegmon. Results obtained were excellent in 11 cases, good in 2 cases and poor in one case. The bacteriological effect of L-627 was excellent, all causative organisms (Staphylococcus aureus one strain, Streptococcus pyogenes 2 strains, Streptococcus pneumoniae 3 strains, Escherichia coli 3 strains, Haemophilus influenzae one strain, Haemophilus parainfluenzae one strain) were eradicated. No significant side effects due to the drug were observed in any cases, except 2 cases each of elevated eosinophil counts and elevated platelet counts.
Nishimura
T
T
Department of Pediatrics, Osaka Medical College.
Sugita
K
K
Aoki
S
S
Takagi
M
M
D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011014:Pneumonia / Q000188:drug therapy / Q000382:microbiology; D013845:Thienamycins / Q000494:pharmacology / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology
D013845:Thienamycins; C065257:biapenem