title: Assessment of bone marrow involvement by magnetic resonance imaging in small cell lung cancer. No significant change of staging.
abstract: OBJECTIVE
  This prospective study was performed in an attempt to evaluate (1) the rate of magnetic resonance imaging (MRI) demonstrating bone marrow (BM) abnormalities, (2) the correlation of these abnormalities with a pathologic malignant BM involvement, and (3) the possible modification of patients' usual disease staging in the light of these abnormalities.
  
  
  METHODS
  After extensive staging investigations, patients' diseases were classified as limited or extensive. Dorsal and lumbar spine MRI was performed for second staging.
  
  
  RESULTS
  Thirty-two patients were eligible for this study. In ten patients (31.2 percent), MRI showed abnormalities; in four of them, the BM sample from the posterior iliac crest was free from malignancy. Three of these four patients had extensive disease. The last patient, because he had limited disease, had biopsy at the site of MRI abnormalities; the biopsy specimen revealed a malignant involvement and therefore this patient, initially classified as having limited disease, was classified in the extensive disease group. In only 1 of 32 patients, BM-MRI data modified initial staging.
  
  
  CONCLUSIONS
  The metastases disclosure yield of the MRI in the detection of medullar involvement is higher than BM biopsy but especially in patients with extensive disease. Therefore, MRI should not be considered in routine practice, in particular in patients with extensive disease.
authors.affiliation: Department of Respiratory Medicine, Hopital Tenon, Paris, France.
authors.forename: B J
authors.initials: BJ
authors.lastname: Milleron
authors.forename: C
authors.initials: C
authors.lastname: Le Breton
authors.forename: M F
authors.initials: MF
authors.lastname: Carette
authors.forename: J L
authors.initials: JL
authors.lastname: Cadranel
authors.forename: G M
authors.initials: GM
authors.lastname: Akoun
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000556:secondary*; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology; D008159:Lumbar Vertebrae / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000556:secondary*; D013904:Thoracic Vertebrae / Q000473:pathology*