title: 19-Bromo-1-hydroxymethylbilane, a novel inhibitor of uro'gen III synthase.
abstract: A novel hydroxymethylbilane analog, 19-Br-HMB (11), has been synthesized. Its activity with the enzyme Uro'gen III synthase shows competitive inhibition.
authors.affiliation: Department of Chemistry, Texas A & M University, College Station 77843-3255.
authors.forename: C
authors.initials: C
authors.lastname: Pichon
authors.forename: B P
authors.initials: BP
authors.lastname: Atshaves
authors.forename: R
authors.initials: R
authors.lastname: Danso-Danquah
authors.forename: N J
authors.initials: NJ
authors.lastname: Stolowich
authors.forename: A I
authors.initials: AI
authors.lastname: Scott
mesh_terms: D001667:Binding, Competitive; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D014576:Uroporphyrinogen III Synthetase / Q000037:antagonists & inhibitors*; D014577:Uroporphyrinogens / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C089686:19-bromo-1-hydroxymethylbilane; C089687:19-methyl-1-hydroxymethylbilane; D014577:Uroporphyrinogens; D014576:Uroporphyrinogen III Synthetase