title: [The antiandrogen treatment of patients with prostatic cancer and bone metastases].
abstract: In 1980-1990 the treatment for prostatic cancer in the urological department of the National Cancer Research Center was administered to 383 patients. In 208 of these the tumour disseminated to the bones. Metastases to the bones were identified by radioisotope scintigraphy of the skeletal bones, x-ray evidence being false-negative. Clinical response was achieved in 87 patients treated with nonsteroid antiandrogens, anandron administration, in particular, brought about a subjective effect in 97.1%, an objective one in 50% of the patients. Flutamid treatment proved effective subjectively in 90.5% and objectively in 42.4% of the patients. For niphtalid administration subjective and objective effects were 85% and 30%, respectively. Compared to estrogens, antiandrogens caused no serious complications. The authors recommend the drugs studied for a wide clinical application.
authors.forename: B P
authors.initials: BP
authors.lastname: Matveev
authors.forename: B V
authors.initials: BV
authors.lastname: Bukharkin
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Zhumagazin
mesh_terms: D000328:Adult; D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D004341:Drug Evaluation; D005485:Flutamide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects; D048289:Imidazolidines; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D011788:Quality of Life
chemical_list: D000726:Androgen Antagonists; D007093:Imidazoles; D048289:Imidazolidines; C021277:nilutamide; D005485:Flutamide
vernacular_title: Lechenie antiandrogenami bol'nykh rakom predstatel'noĭ zhelezy s metastazami v kosti.