Cyclosporin hypertension in the Wistar rat: role of uninephrectomy.
1. The effects of cyclosporin A (CyA) solution (1-50 mg/kg per day), CyA powder (5-20 mg/kg per day) and vehicle, and the effects of renal mass reduction on CyA induced hypertension, were examined in conscious Wistar rats. 2. CyA solution consistently increased blood pressure at 5-20 mg/kg per day and the powder at 10-20 mg/kg per day. The vehicle had no consistent effect. 3. Both CyA solution and powder inhibited gain in bodyweight. There was no consistent effect on food intake, water intake or urine volume. Plasma sodium (Na+), and Na+ and potassium (K+) excretion were reduced by CyA 20 mg/kg per day. 4. Renal function was impaired by CyA powder at 20 mg/kg per day and plasma renin activity (PRA) was increased by all doses of CyA powder. 5. Thus, uninephrectomy did not potentiate CyA solution (5 mg/kg per day) induced increases in blood pressure and the effects of CyA do not appear to be a consequence of nephrotoxicity in Wistar rats.
Martin
A
A
Department of Medicine, St George Hospital, University of New South Wales, Sydney, Australia.
Wong
K S
KS
Li
M
M
Turner
S W
SW
Whitworth
J A
JA
D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003404:Creatinine / Q000652:urine; D016572:Cyclosporine / Q000097:blood / Q000633:toxicity*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D006973:Hypertension / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects*; D014677:Pharmaceutical Vehicles; D010919:Placebos; D011188:Potassium / Q000097:blood / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood / Q000502:physiology; D012964:Sodium / Q000097:blood / Q000652:urine
D014677:Pharmaceutical Vehicles; D010919:Placebos; D016572:Cyclosporine; D012964:Sodium; D003404:Creatinine; D012083:Renin; D011188:Potassium