Breast cancer prevention: a summary of the chemoprevention trial with tamoxifen.
OBJECTIVE
To review the Breast Cancer Prevention Trial, which is testing tamoxifen as a chemoprevention agent.


METHODS
Published articles and books; National Surgical Adjuvant Breast Project protocols.


RESULTS
Because tamoxifen has proven to be an effective hormonal agent in the treatment of all stages of breast cancer and because it has a low side effect rate, a national study is under way to determine its effects as a breast cancer preventive agent.


CONCLUSIONS
Results of this double-blind, placebo-controlled study will be available at the study's completion in 1997.


CONCLUSIONS
Providing patients with education, informed consent assistance, and help in adjusting to the drug's side effects and influences on quality of life.
Gould
K
K
Stanford University Medical Center Bone Marrow Transplant Program, CA.
Gates
M L
ML
Miaskowski
C
C
D001943:Breast Neoplasms / Q000453:epidemiology / Q000451:nursing / Q000517:prevention & control* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D010919:Placebos; D011322:Primary Prevention / Q000379:methods*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013629:Tamoxifen / Q000494:pharmacology / Q000627:therapeutic use*
D010919:Placebos; D013629:Tamoxifen