Differences in serum follicle-stimulating hormone uptake after intramuscular and subcutaneous human menopausal gonadotropin injection.
OBJECTIVE
To determine the difference in FSH bioavailability from IM and SC injection sites.


METHODS
Menotropin was injected into either an IM or SC site in women undergoing ovarian suppression with leuprolide acetate. Serial serum samples were obtained over 96 hours.


METHODS
Academic tertiary care institution.


METHODS
Seven volunteer cycling women.


METHODS
Follicle-stimulating hormone, LH, and E2 were determined in serial serum samples.


RESULTS
Peak serum FSH levels were higher and occurred earlier after IM injection than after SC injection. Computed absorption rate constants for FSH after IM and SC injection differed significantly.


CONCLUSIONS
The pharmacokinetics of FSH differ after a single IM or SC injection.
Dobbs
K E
KE
Department of Obstetrics and Gynecology, University of Wisconsin, Madison.
Dumesic
D A
DA
Dumesic
J A
JA
Shapiro
S S
SS
D000042:Absorption; D000328:Adult; D001682:Biological Availability; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D016729:Leuprolide / Q000008:administration & dosage; D007986:Luteinizing Hormone / Q000097:blood; D008596:Menotropins / Q000008:administration & dosage* / Q000494:pharmacology
D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide