title: Henoch-Schönlein purpura in rheumatoid arthritis.
abstract: This is the first report of Henoch-Schönlein purpura associated with permanent joint damage due to rheumatoid arthritis, which was observed in 3 of the 10 adults we treated for Henoch-Schönlein purpura since 1974. Each of 3 women had been admitted with palpable purpura of the lower extremities. The diagnosis was based on various findings including arthralgia, stiffness, and/or swelling of the joints, and on the results of radiographic, immunofluorescence and other studies. Renal biopsy revealed slight mesangial proliferation in 2 of the patients. The nephropathy did not deteriorate following discharge. However, bilateral swelling of the wrists with destructive joint changes was subsequently observed on radiographs in all patients. Since 2 patients showed positivity for human leukocyte antigen DR4, this antigen may have been a genetic factor in the joint disease in these patients.
authors.affiliation: Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mitsuhashi
authors.forename: M
authors.initials: M
authors.lastname: Mitsuhashi
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukada
authors.forename: S
authors.initials: S
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Naruse
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D014955:Wrist Joint / Q000000981:diagnostic imaging
chemical_list: D011239:Prednisolone