title: Prophylactic amnioinfusion in pregnancies complicated by thick meconium.
abstract: OBJECTIVE
  We hypothesized that prophylactic intrapartum amnioinfusion in pregnancies complicated by thick meconium will not decrease the incidence of fetal distress, cesarean section for fetal distress, or meconium below the cords.
  
  
  METHODS
  Patients with thick meconium were randomized to amnioinfusion (n = 65) or control (n = 59). The amnioinfusion group received an 800 ml bolus of normal saline solution followed by a continuous infusion at 180 ml/hr. Continuous variables were compared by Student t test, and discrete variables were compared by chi 2 analysis and Fisher's exact test as appropriate.
  
  
  RESULTS
  The incidence of fetal distress (16 of 65 vs 8 of 59) and cesarean section for fetal distress (seven of 65 vs seven of 59) was not significantly different between the amnioinfusion and control groups, respectively. The rate of meconium below the cords (one of 65 vs eight of 59) was significantly lower in patients receiving amnioinfusion (relative risk 0.09, confidence interval 0.01 and 0.82, p = 0.02). Two cases of meconium aspiration syndrome occurred in control patients but in none receiving amnioinfusion (p = 0.22).
  
  
  CONCLUSIONS
  Prophylactic amnioinfusion in patients with thick meconium decreases the incidence of meconium below the cords and may subsequently have an impact on the incidence of meconium aspiration syndrome in larger series.
authors.affiliation: University of Texas, Houston 77026.
authors.forename: N L
authors.initials: NL
authors.lastname: Eriksen
authors.forename: M
authors.initials: M
authors.lastname: Hostetter
authors.forename: V M
authors.initials: VM
authors.lastname: Parisi
mesh_terms: D000293:Adolescent; D000328:Adult; D000650:Amnion; D002585:Cesarean Section; D016009:Chi-Square Distribution; D005260:Female; D005316:Fetal Distress / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D008470:Meconium; D008471:Meconium Aspiration Syndrome / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D011256:Pregnancy Outcome; D012965:Sodium Chloride / Q000008:administration & dosage*
chemical_list: D012965:Sodium Chloride