Effect of age at onset on frequency of depression in Parkinson's disease.
In a consecutive series of 169 outpatients with Parkinson's disease the frequency of depression was compared in two groups: those who developed Parkinson's disease before the age of 50, and those who developed the disease after 50. Major depression was found in 36% of patients with early onset and in 16% of patients with late onset Parkinson's disease. This significant difference disappeared when both groups were matched for duration of Parkinson's disease. A stepwise regression analysis in both the early onset and the late onset Parkinson's disease showed a significant correlation only between depression scores and the impairment scores of activities of daily living.
Kostíc
V S
VS
Institute for Neurology CCS, Belgrade, Yugoslavia.
Filipović
S R
SR
Lecić
D
D
Momcilović
D
D
Sokić
D
D
Sternić
N
N
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000704:Analysis of Variance; D003866:Depressive Disorder / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000523:psychology*