title: Peripartum infection associated with vaginal group B streptococcal colonization.
abstract: OBJECTIVE
  To determine the frequency of peripartum infection in parturients colonized with group B streptococci.
  
  
  METHODS
  We screened 915 obstetric patients for group B streptococcal colonization using selective broth media; 823 had vaginal cultures performed within 2 weeks preceding delivery and received complete follow-up. Vaginal group B streptococcal colonization and other risk factors for peripartum maternal infection were assessed using univariate and multivariate logistic modeling.
  
  
  RESULTS
  Two hundred sixteen women (26%, 95% confidence interval [CI] 23-29) were colonized with group B streptococci. Chorioamnionitis or endometritis occurred in 45 of 216 colonized women (21%, 95% CI 15.6-26.4) and 72 of 607 women who were not colonized (12%, 95% CI 9-15; P < .01). When confounding variables were controlled in a multivariate analysis, the association between group B streptococcal colonization and chorioamnionitis, but not endometritis, was confirmed (odds ratio 3.6, 95% CI 2.1-6.2). The risk of chorioamnionitis increased in a stepwise fashion with light (odds ratio 1.9, 95% CI 1.0-3.7), moderate (odds ratio 2.6, 95% CI 1.3-5.2), and heavy (odds ratio 3.2, 95% CI 1.5-6.6) colonization.
  
  
  CONCLUSIONS
  Intrapartum vaginal colonization with group B streptococci is an important independent risk factor for chorioamnionitis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville.
authors.forename: M K
authors.initials: MK
authors.lastname: Yancey
authors.forename: P
authors.initials: P
authors.lastname: Duff
authors.forename: P
authors.initials: P
authors.lastname: Clark
authors.forename: T
authors.initials: T
authors.lastname: Kurtzer
authors.forename: B H
authors.initials: BH
authors.lastname: Frentzen
authors.forename: P
authors.initials: P
authors.lastname: Kubilis
mesh_terms: D002821:Chorioamnionitis / Q000382:microbiology; D004716:Endometritis / Q000382:microbiology; D005260:Female; D006801:Humans; D016017:Odds Ratio; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000382:microbiology*; D011446:Prospective Studies; D012307:Risk Factors; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000302:isolation & purification*; D014621:Vagina / Q000382:microbiology*