Long-term survivors of HIV infection.
The persistent immune competence seen in a small percentage of HIV-infected individuals reflects the heterogeneity of both the virus and the host. Some HIV strains, for example, are more cytopathic than others. Host factors that promote longer survival lack "enhancing" antibodies, an appropriate balance of two crucial CD4+ cell subsets and their cytokines, and a strong CD8+ cell antiviral response.
Levy
J A
JA
Department of Medicine, University of California, San Francisco, School of Medicine.
D000818:Animals; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D006801:Humans; D007121:Immunocompetence / Q000276:immunology*; D008297:Male; D051379:Mice; D016513:Mice, SCID; D009517:New South Wales / Q000453:epidemiology; D012495:San Francisco / Q000453:epidemiology; D015996:Survival Rate; D017741:Survivors; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013997:Time Factors
D016207:Cytokines