title: [Amelioration of aminoglycoside nephrotoxicity by Cordyceps sinensis in old patients].
abstract: The protective effect on aminoglycoside nephrotoxicity by Cordyceps sinensis in the old patient was observed. 21 old patients were randomly divided into two groups. Each group received amikacin sulfate for 6 days. In addition, group A was administered Cordyceps sinensis for 7 days and group B was given placebo. The results revealed that group A developed less prominent nephrotoxicity compared with group B as evidenced by less urinary nephro-aminoglycosidase (NAGase) and beta-microglobulin in group A than those in Group B. These results suggested that Cordyceps sinensis exerted a protective effect on aminoglycoside nephrotoxicity in the old patients.
authors.affiliation: Dept. of Geriatrics, Jinling Hospital, Nanjing.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Bao
authors.forename: Z G
authors.initials: ZG
authors.lastname: Wu
authors.forename: F
authors.initials: F
authors.lastname: Zheng
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000368:Aged; D000583:Amikacin / Q000009:adverse effects*; D000818:Animals; D001991:Bronchitis / Q000188:drug therapy / Q000652:urine; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006999:Hypocreales; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009036:Moths; D011014:Pneumonia / Q000188:drug therapy / Q000652:urine; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D004365:Drugs, Chinese Herbal; D001613:beta 2-Microglobulin; D000583:Amikacin; D000118:Acetylglucosaminidase