title: Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues.
abstract: Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro 16-6491 was replaced by an ester bond an increase in potency of the order of 150-200 times was obtained.
authors.affiliation: Division of Biochemistry, Queen's University, Belfast, United Kingdom.
authors.forename: E L
authors.initials: EL
authors.lastname: Mullan
authors.forename: C H
authors.initials: CH
authors.lastname: Williams
mesh_terms: D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D002417:Cattle; D007700:Kinetics; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*
chemical_list: D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; C051040:Ro 16-6491; D008995:Monoamine Oxidase