Alteration in regional brain neuropeptides following intracerebroventricular infusion of excitotoxins in rats.
We determined regional brain concentrations of somatostatin (SS), neuropeptide Y (NPY) and arginine-vasopressin (AVP) in 3- and 13-month-old rats. We also examined the effects of the excitotoxins, ibotenic acid (IA), kainic acid (KA), and quinolinic acid (QA) on regional levels of brain neuropeptides in rats. Excitotoxins were infused continuously into the lateral ventricle for 14 days using an osmotic minipump. Our results indicate that; (1) NPY in the brain is especially vulnerable to aging, compared to AVP. (2) IA induces a decrease in brain regional concentrations of neuropeptides and the effects are different from those of other excitotoxins, for example, KA and QA. (3) These effects of IA on neuropeptides may be dependent on the age of the animals when exposed and on the dose of IA.
Kaneda
H
H
Department of Psychiatry, Kobe University School of Medicine, Japan.
Maeda
K
K
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000187:drug effects*; D001931:Brain Mapping; D018846:Excitatory Amino Acids / Q000494:pharmacology*; D007051:Ibotenic Acid / Q000494:pharmacology; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism*; D017378:Quinolinic Acid / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism
D018846:Excitatory Amino Acids; D009478:Neuropeptide Y; D009479:Neuropeptides; D007051:Ibotenic Acid; D013004:Somatostatin; D017378:Quinolinic Acid; D007608:Kainic Acid