Determination of lignans and isoflavonoids in human female plasma following dietary supplementation.
Plasma levels of the lignans enterodiol and enterolactone, and also the isoflavonic phyto-oestrogens daidzein, equol and genistein, are reported for postmenopausal Australian women consuming a traditional diet supplemented with linseed, soya flour or clover sprouts. Analysis was performed by gas chromatography-mass spectrometry, after enzymatic hydrolysis and ion-exchange chromatography. Following linseed supplementation, combined levels of enterolactone and enterodiol reached 500 ng/ml, whereas after soya flour or clover sprouts the respective concentrations of equol, daidzein and genistein reached 43, 312 and 148 ng/ml. Not all subjects were able to produce equol from daidzein. The possible relationship and role of these weak dietary oestrogens as restraining factors in the development of hormone-dependent cancers in Asian populations is discussed.
Morton
M S
MS
Tenovus Cancer Research Centre, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Wilcox
G
G
Wahlqvist
M L
ML
Griffiths
K
K
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000097:blood; D001315:Australia; D002839:Chromans / Q000097:blood; D004032:Diet; D060754:Equol; D004967:Estrogens / Q000097:blood; D005260:Female; D005527:Food, Fortified; D008401:Gas Chromatography-Mass Spectrometry; D019833:Genistein; D006801:Humans; D007529:Isoflavones / Q000097:blood*; D017705:Lignans / Q000097:blood*; D008043:Linseed Oil / Q000008:administration & dosage; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000097:blood; D009369:Neoplasms / Q000517:prevention & control; D010945:Plants, Edible; D017698:Postmenopause / Q000097:blood; D013025:Glycine max
C007610:4',7-dihydroxy-3,4-dihydroisoflavone; D002839:Chromans; D004967:Estrogens; D007529:Isoflavones; D017705:Lignans; D008996:Monoamine Oxidase Inhibitors; D060754:Equol; C004742:daidzein; C029498:2,3-bis(3'-hydroxybenzyl)butane-1,4-diol; D008043:Linseed Oil; D019833:Genistein; D015107:4-Butyrolactone; C029497:2,3-bis(3'-hydroxybenzyl)butyrolactone