title: Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A.
abstract: Chronic treatment of rats with clorgyline (1 mg/kg i.p. daily for 21 days) caused a highly significant increase in the concentration of noradrenaline in microdialysate from the frontal cortex of the awake animal. Acute (one injection, 2 mg/kg) or subacute (1 mg/kg daily for 3 days) treatment did not lead to a significant increase in microdialysate noradrenaline. Concentrations of deaminated metabolites (DPHG, MHPG, DOPAC) in the microdialysate decreased with time of treatment, reaching a minimum after 21 days.
authors.affiliation: Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: J P
authors.initials: JP
authors.lastname: Finberg
authors.forename: K
authors.initials: K
authors.lastname: Pacak
authors.forename: D S
authors.initials: DS
authors.lastname: Goldstein
authors.forename: I J
authors.initials: IJ
authors.lastname: Kopin
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D003010:Clorgyline / Q000008:administration & dosage / Q000494:pharmacology; D017551:Microdialysis; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D009994:Osmolar Concentration; D051381:Rats; D013997:Time Factors
chemical_list: D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D003010:Clorgyline; D009638:Norepinephrine