Postinfantile giant cell hepatitis associated with anti-M2 mitochondrial antibodies.
Whereas giant cell hepatitis (GCH) is a common diagnosis made in neonates, it is rare in the adult population. The diagnosis of GCH is based on the presence of giant cell transformation of hepatocytes. It is commonly associated with either viral hepatitis or autoimmune disorders. A patient with GCH who had anti-M2 mitochondrial antibodies is described. This combination, which has not been previously reported, underscores the association of GCH with autoimmune disorders and stresses the importance of corticosteroids as an empirical initial therapy.
Rabinovitz
M
M
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania.
Demetris
A J
AJ
D000208:Acute Disease; D000906:Antibodies / Q000032:analysis*; D001706:Biopsy; D006505:Hepatitis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology*
D000906:Antibodies