title: Pneumocystis carinii pneumonia prophylaxis during pregnancy.
abstract: The frequency of human immunodeficiency virus (HIV) infection among pregnant women is increasing. Pneumocystis carinii pneumonia (PCP) is the most common opportunistic infection in HIV-infected patients, and prophylaxis is an important part of decreasing morbidity. Trimethoprim-sulfamethoxazole (TMP-SMX), pentamidine, and dapsone, alone or in combination with pyrimethamine, are the most commonly used drugs for PCP prophylaxis in the nonpregnant HIV-infected population. Trimethoprim-sulfamethoxazole, however, has the potential for adverse effects in the fetus. Limited data are available for the other agents administered as prophylaxis of PCP.
authors.affiliation: Department of Infectious Diseases, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois.
authors.forename: R T
authors.initials: RT
authors.lastname: Connelly
authors.forename: D L
authors.initials: DL
authors.lastname: Lourwood
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003622:Dapsone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010419:Pentamidine / Q000627:therapeutic use; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D010419:Pentamidine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003622:Dapsone