Calcitonin-producing insulinoma: clinical, immunocytochemical and cytogenetical study.
The case of a patient with a large goitre associated with hypercalcitoninaemia and fasting hypoglycaemia is reported. Pentagastrin (PG) test was negative. Repeated measurements of fasting glycaemia, insulin and C peptide established the diagnosis of insulinoma. After localization by endoscopic ultrasonography, a distal pancreatectomy was performed and a small insulinoma was recovered. Glycaemia and calcitonin (CT) became normal. The tumour cells displayed a strong immunoreactivity for insulin and CT. Cytogenetical evaluation of the tumour revealed a translocation t(1;9) (p13;p22).
Bugalho
M J
MJ
Department of Endocrinology, Portuguese Cancer Institute, Lisbon, Portugal.
Roque
L
L
Sobrinho
L G
LG
Hoog
A
A
Nunes
J F
JF
Almeida
J M
JM
Leitão
C N
CN
Santos
J R
JR
Pereira
M C
MC
Santos
M A
MA
D000368:Aged; D002116:Calcitonin / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006042:Goiter / Q000209:etiology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007328:Insulin / Q000032:analysis; D007340:Insulinoma / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007621:Karyotyping; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014178:Translocation, Genetic
D007328:Insulin; D002116:Calcitonin