title: Tubulointerstitial nephritis and vasculitis.
abstract: This review discusses recent developments in infectious tubulointerstitial nephritis, including bacterial virulence factors, the interaction between leukocytes and bacteria, and early events in inflammation. In the area of vasculitis, little-studied specificities of antineutrophil cytoplasmic antibodies (ANCAs), including lactoferrin and elastase, plus newly described ANCAs with alpha-enolase specificity are discussed, along with newer studies on the pathogenesis of ANCA-mediated damage and animal models for ANCA-related vasculitis.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: G S
authors.initials: GS
authors.lastname: Hill
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators; D007962:Leukocytes / Q000276:immunology; D009395:Nephritis, Interstitial / Q000276:immunology* / Q000382:microbiology; D014657:Vasculitis / Q000276:immunology*
chemical_list: D001426:Bacterial Proteins; D016207:Cytokines; D018836:Inflammation Mediators