Rapid onset of chronic granulocytic leukaemia after treatment for Hodgkin's disease.
A 17-year-old white female presented with stage IVB Hodgkin's disease. After chemotherapy and radiotherapy she achieved a complete clinical remission and underwent an autologous bone marrow transplant (ABMT). 22 months later she developed chronic granulocytic leukaemia (CGL). Polymerase chain reaction (PCR) analysis of bone marrow harvested at the time of ABMT did not show any evidence of the bcr-abl sequence that was detectable at the diagnosis of CGL. This case provides further information on the kinetics of the development of CGL and adds to the small pool of data on CGL developing after treatment for Hodgkin's disease.
Jackson
G H
GH
Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne.
Latham
J A
JA
Lennard
A L
AL
Taylor
P R
PR
Proctor
S J
SJ
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000737:chemistry; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D016044:Fusion Proteins, bcr-abl / Q000096:biosynthesis; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D013997:Time Factors
D016044:Fusion Proteins, bcr-abl