title: Statistical analysis of topographic maps of short-latency somatosensory evoked potentials in normal and parkinsonian subjects.
abstract: This work had the following objectives: i) to integrate temporal analysis (N30 peak) with power-spectrum topographic mapping of short-latency somatosensory evoked potentials (SEP's) recorded in parkinsonian and normal control subjects; and ii) to analyze with a new statistical approach the between-group topographical differences in both the time and frequency domains. The principal aim was to better determine the topography of the scalp frontal areas where the amplitude of the N30 wave was previously found to be significantly reduced in parkinsonians. The statistical procedure was based on the combined use of descriptive data analysis (DDA) and multivariate analysis. In the context of DDA, an improved version of significance probability mapping (SPM) was used by which it is possible to evaluate homo- and nonhomoscedastic data with parametric tests. The statistical evaluation of between-group differences was performed with the multivariate Hotelling's T2 test and the associated post hoc test. With this statistical procedure, it was possible to determine that the between-group statistical differences in both the temporal and power spectrum distributions were localized only in midline and contiguous contralateral frontal areas of the scalp.
authors.affiliation: Institute of Human Physiology, University of Rome, La Sapienza, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Babiloni
authors.forename: C
authors.initials: C
authors.lastname: Babiloni
authors.forename: L
authors.initials: L
authors.lastname: Cecchi
authors.forename: P
authors.initials: P
authors.lastname: Onorati
authors.forename: S
authors.initials: S
authors.lastname: Salinari
authors.forename: A
authors.initials: A
authors.lastname: Urbano
mesh_terms: D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology* / Q000503:physiopathology; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D005583:Fourier Analysis; D006801:Humans; D008432:Mathematical Computing; D015999:Multivariate Analysis; D010300:Parkinson Disease / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted; D013269:Stochastic Processes