[Treatment of dyslipidemia of the elderly with simvastatin and pravastatin. Effectiveness and tolerance].
After reviewing the literature concerning the advisability and efficacy of dyslipidemia treatment in old age, the authors present their experience with the use of HMG CoA reductase inhibitors. Twenty-five patients were treated with simvastatin and 20 with pravastatin. Already after one month of therapy, both drugs had induced a reduction of total cholesterol, LDL-cholesterol, and triglycerides, as well as an increase of HDL-cholesterol. These changes were found to be even more marked after three months of treatment. Altogether, tolerability of both drugs was good. However, recurrent episodes of nose bleeding were observed in two patients with normal blood clotting activity.
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Ospedale Simiani Loiano, Divisione di Medicina Generale, USL 22 di S. Lazzaro di Savona.
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Romani
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D000368:Aged; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D017035:Pravastatin / Q000627:therapeutic use*; D019821:Simvastatin; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D014280:Triglycerides; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin; D017035:Pravastatin
Trattamento delle dislipidemie dell'anziano con sinvastatina e pravastatina. Efficacia e tollerabilità.