Is there a long-lasting effect of a short-term nerve growth factor application on axotomized rat septohippocampal neurons?
Loss of choline acetyltransferase (ChAT)-immunoreactive neurons in the medial septum (MS) following fimbria transection can be prevented by nerve growth factor (NGF) application. Here we have studied the long-term effects of a short-term NGF treatment starting immediately after lesion and lasting for the first 3 weeks. We demonstrate that this NGF treatment rescues many ChAT neurons after short survival time (3 weeks) but does not have a long-lasting (6 months) effect on both ChAT- and parvalbumin-immunopositive (GABAergic) MS neurons.
Naumann
T
T
Institute of Anatomy, University of Freiburg, FRG.
Kermer
P
P
Seydewitz
V
V
Ortmann
R
R
D'Amato
F
F
Frotscher
M
M
D000818:Animals; D001369:Axons / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D002795:Choline O-Acetyltransferase / Q000276:immunology / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D007276:Injections, Intraventricular; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D010320:Parvalbumins / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D009414:Nerve Growth Factors; D010320:Parvalbumins; D005680:gamma-Aminobutyric Acid; D002795:Choline O-Acetyltransferase