title: The dynamic regulation of integrin adhesiveness.
abstract: The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular signal transduction pathways.
authors.affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: M S
authors.initials: MS
authors.lastname: Diamond
authors.forename: T A
authors.initials: TA
authors.lastname: Springer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D015398:Signal Transduction
chemical_list: D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D016023:Integrins