[Suppressive effect of methylparaben on the evoked compound action potentials in excised rabbit cervical vagus nerve].
We evaluated the effects of methylparaben on rabbit vagus nerve by measuring the amplitudes and latencies of the evoked compound action potentials during incubation in 0.1% methylparaben containing Ringer's bicarbonate solution. We also evaluated the histological changes of the nerves after incubation in methylparaben-RB solution by means of the electron microscopy. We found that 0.1% methylparaben caused complete suppression of the compound action potentials, which recovered completely after washing in methylparaben-free RB solution. The electron microscopic studies revealed no histological changes of nerves incubated in 0.1% methylparaben containing RB solution. We conclude that methylparaben suppresses nerve excitability dose-dependently, but does not destroy nervous tissues in concentrations up to 0.1%.
Mizuno
K
K
Department of Anesthesiology, Surugadai Nihon University Hospital, Tokyo.
Ogawa
S
S
Itoh
S
S
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D066298:In Vitro Techniques; D010226:Parabens / Q000494:pharmacology*; D011817:Rabbits; D014630:Vagus Nerve / Q000187:drug effects* / Q000648:ultrastructure
D010226:Parabens; C015358:methylparaben