The effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in HIV-seropositive persons.
Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4+, CD4+45RA+, and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4+ cells is preferable to the number of CD4+ cells in monitoring patients seropositive for HIV.
Ullum
H
H
Copenhagen Muscle Research Center, Department of Infectious Diseases, Rigshospitalet, Denmark.
Palmø
J
J
Halkjaer-Kristensen
J
J
Diamant
M
M
Klokker
M
M
Kruuse
A
A
LaPerriere
A
A
Pedersen
B K
BK
D000328:Adult; D018791:CD4 Lymphocyte Count; D016207:Cytokines / Q000096:biosynthesis; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000276:immunology; D005082:Physical Exertion / Q000502:physiology*; D010976:Platelet Count; D013312:Stress, Physiological / Q000150:complications / Q000276:immunology*
D016207:Cytokines; D006454:Hemoglobins; D007376:Interleukin-2