title: Dose response of succinylcholine at the adductor pollicis of children with cerebral palsy during propofol and nitrous oxide anesthesia.
abstract: Children with cerebral palsy may be resistant to paralysis induced by nondepolarizing neuromuscular blocking drugs. Potency of a bolus of succinylcholine in children with cerebral palsy has not been studied previously. Therefore, we measured the response of the adductor pollicis to succinylcholine in children with cerebral palsy anesthetized with propofol and nitrous oxide. Forty children between the ages of 2 and 10.2 yr with spastic quadriplegic cerebral palsy were randomly assigned to receive 100, 175, 250, or 375 micrograms/kg of succinylcholine during anesthesia with propofol and nitrous oxide. The ulnar nerve was stimulated with a train-of-four supramaximal stimulus every 10 s and the compound electromyogram of the adductor pollicis recorded by a Datex NMT monitor. Plasma cholinesterase activity was measured in all patients with three different substrates (propionylthiocholine, benzoylcholine, and succinylcholine). Dibucaine number was also determined using inhibition of benzoylcholine degradation. ED50 of succinylcholine was 146.8 micrograms/kg with 95% confidence intervals of 111.4-193.7 micrograms/kg. ED95 of succinylcholine was 360.5 micrograms with 95% confidence intervals of 273.3-475.5 micrograms/kg. We conclude that children with cerebral palsy are slightly sensitive to succinylcholine, but probably not sufficiently to be clinically important.
authors.affiliation: Department of Anesthesiology, Alfred I. duPont Institute, Wilmington, DE 19899.
authors.forename: M C
authors.initials: MC
authors.lastname: Theroux
authors.forename: B W
authors.initials: BW
authors.lastname: Brandom
authors.forename: M
authors.initials: M
authors.lastname: Zagnoev
authors.forename: R G
authors.initials: RG
authors.lastname: Kettrick
authors.forename: F
authors.initials: F
authors.lastname: Miller
authors.forename: C
authors.initials: C
authors.lastname: Ponce
mesh_terms: D000768:Anesthesia, General; D002547:Cerebral Palsy / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D002802:Cholinesterases / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D006801:Humans; D009132:Muscles / Q000187:drug effects* / Q000294:innervation / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000187:drug effects*; D009609:Nitrous Oxide; D010027:Osteotomy; D015742:Propofol; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D013933:Thumb
chemical_list: D002802:Cholinesterases; D013390:Succinylcholine; D009609:Nitrous Oxide; D015742:Propofol