title: Role of the vestibular commissure in gaze-holding in the cat: a pharmacological evaluation.
abstract: Recent theoretical studies have proposed that the vestibular commissure is a major component of the horizontal gaze-holding system. In order to test this hypothesis, we injected either bicuculline, a GABA receptor antagonist, or strychnine, a glycine receptor antagonist, into the medial vestibular nucleus of alert cats. The intervestibular connection is indeed inhibitory and mediated by GABA and glycine. As neither bicuculline nor strychnine caused serious deficit of the gaze-holding system, we conclude that the vestibular commissure is not essential for gaze-holding.
authors.affiliation: Laboratory of Neurosciences, University of Mons-Hainaut, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Mettens
authors.forename: G
authors.initials: G
authors.lastname: Cheron
authors.forename: E
authors.initials: E
authors.lastname: Godaux
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage / Q000494:pharmacology; D002415:Cats; D005133:Eye Movements / Q000187:drug effects / Q000502:physiology*; D005998:Glycine / Q000494:pharmacology; D008845:Microinjections; D013331:Strychnine / Q000008:administration & dosage / Q000494:pharmacology; D014726:Vestibular Nuclei / Q000187:drug effects / Q000502:physiology*; D014796:Visual Perception / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D005680:gamma-Aminobutyric Acid; D013331:Strychnine; D005998:Glycine; D001640:Bicuculline