Pyridazine analogs of piperidinylbenzophenone immunomodulators. 70th communication: syntheses and reactions of pyridazines.
Starting from conveniently accessible halogen-substituted phenyl pyridazinyl ketones, a series of piperidinyl-substituted diazabenzophenones was prepared. The new compounds were screened for immunomodulatory activity.
Haider
N
N
Institute of Pharmaceutical Chemistry, University of Innsbruck, Austria.
Heinisch
G
G
Moshuber
J
J
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001577:Benzophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004396:Coloring Agents; D051379:Mice; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013778:Tetrazolium Salts; D013844:Thiazoles; D013936:Thymidine / Q000378:metabolism
D000276:Adjuvants, Immunologic; D001577:Benzophenones; D004396:Coloring Agents; D011724:Pyridazines; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue; D013936:Thymidine