Clinical features of adult-relapse asthma in comparison with those of child-onset asthma and adult-onset asthma.
Clinical features of adult-relapse asthma (group B, n = 15) were compared with those of child-onset asthma (group A, n = 18) and adult-onset asthma (group C, n = 34) in terms of allergic component and bronchial hypersensitivity. The percentage of patients with high levels of serum IgE (> 300 U/ml) in groups A, B, and C was 83%, 73%, and 50%, respectively, and the percentage of patients with positive IgE RAST for house dust was 87.5%, 78.6%, and 46.7%, and that for mite was 93.3%, 92.9%, and 58.6% in groups A, B, and C, respectively. The histamine concentration of PC20 for the bronchial hypersensitivity test in groups A, B, and C was 196 micrograms/ml, 500 micrograms/ml, and 724 micrograms/ml, respectively. Thus, the adult-relapse asthma was closer to the child-onset asthma type in allergic state and closer to the adult-onset asthma type in bronchial hypersensitivity state. The classification employed here seemed to provide some merits in delineating the features of adulthood asthma.
Oosaki
R
R
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Mizushima
Y
Y
Kawasaki
A
A
Hoshino
K
K
Kobayashi
M
M
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001249:Asthma / Q000209:etiology / Q000503:physiopathology*; D001982:Bronchial Diseases / Q000150:complications / Q000175:diagnosis; D005260:Female; D006632:Histamine; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000175:diagnosis; D008297:Male; D011852:Radioallergosorbent Test; D012008:Recurrence; D012130:Respiratory Hypersensitivity / Q000150:complications / Q000175:diagnosis
D006632:Histamine