title: Effect of age at onset on frequency of depression in Parkinson's disease.
abstract: In a consecutive series of 169 outpatients with Parkinson's disease the frequency of depression was compared in two groups: those who developed Parkinson's disease before the age of 50, and those who developed the disease after 50. Major depression was found in 36% of patients with early onset and in 16% of patients with late onset Parkinson's disease. This significant difference disappeared when both groups were matched for duration of Parkinson's disease. A stepwise regression analysis in both the early onset and the late onset Parkinson's disease showed a significant correlation only between depression scores and the impairment scores of activities of daily living.
authors.affiliation: Institute for Neurology CCS, Belgrade, Yugoslavia.
authors.forename: V S
authors.initials: VS
authors.lastname: Kostíc
authors.forename: S R
authors.initials: SR
authors.lastname: Filipović
authors.forename: D
authors.initials: D
authors.lastname: Lecić
authors.forename: D
authors.initials: D
authors.lastname: Momcilović
authors.forename: D
authors.initials: D
authors.lastname: Sokić
authors.forename: N
authors.initials: N
authors.lastname: Sternić
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000704:Analysis of Variance; D003866:Depressive Disorder / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000523:psychology*