title: [Assessment of myocardial viability by thallium-201 reinjection imaging with sublingual nitroglycerin].
abstract: Although thallium-201 (201Tl) reinjection imaging improves the detection of myocardial viability compared to standard 3-4-hr redistribution (RD) imaging, it still underestimates the extent of viable myocardium. We examined whether 201Tl reinjection SPECT with sublingual nitroglycerin (NTG) had a higher sensitivity for viability detection than reinjection alone. Eighty patients with coronary artery disease were studied, 38 of them with an old myocardial infarction. At the peak of exercise, 111 MBq 201Tl was injected and the initial and the delayed SPECT images were obtained. Then, all patients were divided randomly into two groups, and in each group, SPECT data were obtained again after the injection of 37 MBq 201Tl with (NTG(+) group) or without 0.6 mg of sublingual NTG (NTG(-) group). Among 50 segments showing fixed defects on the delayed image in the NTG(+) group, 21 (42%) were found to be reversible on the reinjection image, as compared to 16 of 51 (31%) in the NTG(-) group. Twenty-two of 44 (50%) segments showing incomplete RD were found to be reversible in the NTG(+) group, while 17 of 42 (41%) segments in the NTG(-) group. Moreover, the ratio of reversible segments seen in the reinjection images was significantly higher in the collateralized regions of the NTG(+) group than in those of the NTG(-) group (20/26 vs. 14/28, p < 0.05). Thus, 201Tl reinjection SPECT with sublingual NTG improves the detection of ischemic but viable myocardium as compared to SPECT with reinjection alone.
authors.affiliation: Department of Radiology, Ehime National Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Miyagawa
authors.forename: S
authors.initials: S
authors.lastname: Kumano
authors.forename: M
authors.initials: M
authors.lastname: Sekiya
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Hashida
authors.forename: M
authors.initials: M
authors.lastname: Shiode
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Akutsu
authors.forename: T
authors.initials: T
authors.lastname: Imachi
authors.forename: S
authors.initials: S
authors.lastname: Tanada
mesh_terms: D000286:Administration, Sublingual; D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D005996:Nitroglycerin / Q000008:administration & dosage; D013794:Thallium Radioisotopes / Q000008:administration & dosage; D014022:Tissue Survival; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes; D005996:Nitroglycerin