[The effect of interleukin-2, interleukin-4 and tumor necrosis factor on LAK cells activity].
We studied the effect of single or combination of interleukin-2 (IL-2), interleukin-4 (IL-4) and tumor necrosis factor (TNF) on lymphokine-activated killer cells (LAK) activity which killed both of target cells HepG2 and 2 2,1,5 cells induced for seven days. It was shown that LAK activity induced by the combination of triplet of IL-2, IL-4 and TNF was higher than that induced by single or two of IL-2, IL-4 and TNF, and that enhanced LAK activity was associated with the quantity of IL-2 receptor expression and lysosomes of LAK precursors.
Zeng
Z
Z
Department of Infectious Diseases, First Teaching Hospital, Beijing Medical University.
Si
C W
CW
Yu
M
M
D004357:Drug Synergism; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D015847:Interleukin-4 / Q000494:pharmacology*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4