title: The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease.
abstract: We determined apolipoprotein E (ApoE) genotypes in 122 autopsied demented patients. The frequency of the ApoE epsilon 4 allele was 39.6% in Alzheimer's disease (AD), 29.0% in the Lewy body variant of AD (LBV), and 6.25% in diffuse Lewy body disease. For AD and LBV patients, the epsilon 4 frequency was significantly higher than that reported in nondemented controls (10 to 15%). Therefore, LBV and AD share ApoE epsilon 4 as a genetic risk factor, providing further evidence that these conditions overlap.
authors.affiliation: Veterans Affairs Medical Center, San Diego, CA 92161.
authors.forename: D
authors.initials: D
authors.lastname: Galasko
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Xia
authors.forename: L J
authors.initials: LJ
authors.lastname: Thal
authors.forename: R
authors.initials: R
authors.lastname: Katzman
authors.forename: L R
authors.initials: LR
authors.lastname: Hill
authors.forename: L
authors.initials: L
authors.lastname: Hansen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016631:Lewy Bodies; D008297:Male; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E