title: High dietary aluminum affects the response of rats to silicon deprivation.
abstract: Antagonistic interactions between silicon and aluminum occur in living organisms. Thus, an experiment was performed to ascertain whether high dietary aluminum would accentuate the signs of silicon deprivation in rats and conversely whether silicon deprivation would accentuate the response to high dietary aluminum. The experiment was factorially arranged with two variables: silicon as sodium metasilicate, 0 or 40 micrograms/g diet, and aluminum as aluminum citrate, 0 or 500 micrograms/g diet. After 9 wk, body weights and plasma urea nitrogen were higher and plasma concentrations of threonine, serine, glycine, cystine, and methionine were lower in silicon-adequate than silicon-deprived rats. High dietary aluminum significantly decreased plasma phenylalanine. An interaction between aluminum and silicon affected plasma triglyceride, cholesterol, and phosphorus concentrations. High dietary aluminum decreased these variables when silicon was absent from the diet, but increased them when silicon was present. Skull iron and silicon concentrations were decreased and iron and zinc concentrations in the femur were increased by the addition of 500 micrograms Al/g diet. High dietary aluminum decreased tibia density in silicon-adequate rats, but increased tibial density in silicon-deprived rats. The findings indicate that in rats, high dietary aluminum can affect the response to silicon deprivation and dietary silicon can affect the response to high dietary aluminum.
authors.affiliation: United States Department of Agriculture, Grand Forks Human Nutrition Research Center, ND 58202.
authors.forename: C D
authors.initials: CD
authors.lastname: Seaborn
authors.forename: F H
authors.initials: FH
authors.lastname: Nielsen
mesh_terms: D000535:Aluminum / Q000008:administration & dosage*; D000596:Amino Acids / Q000097:blood; D000818:Animals; D001842:Bone and Bones / Q000737:chemistry; D004032:Diet; D008297:Male; D010758:Phosphorus / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012825:Silicon / Q000172:deficiency*
chemical_list: D000596:Amino Acids; D010758:Phosphorus; D000535:Aluminum; D012825:Silicon