title: Evidence for partial sympathetic cardiac reinnervation following cardiac transplantation.
abstract: Heart transplantation causes total cardiac denervation. Measurements of plasma concentrations of the main presynaptic noradrenal metabolite, dihydroxyphenylglycol (DOPEG, exclusively neuronal in origin), were used to examine the possibility of sympathetic reinnervation of the transplanted human heart. We determined arterial and coronary-venous plasma concentrations of DOPEG in 15 heart transplant recipients (28-68 years of age at the time of transplantation with the transplant ageing from 0.5 to 4 years at the time of investigation) and in nine control patients (45-75 years of age). In each of the control patients the DOPEG concentration was higher in coronary venous plasma than in arterial plasma (mean arteriovenous increment: 60 +/- 10%; P < 0.001). In the heart transplant recipients nine patients showed an arteriovenous increment in plasma DOPEG. For the mean group results it was found that the ratio of the coronary-venous to arterial DOPEG concentration was positively correlated with the time after transplantation (r = 0.92; n = 5; P < 0.05). Thus, our data provide neurochemical evidence for partial sympathetic reinnervation in some of the heart transplants. Moreover, it is suggested that the time after transplantation is unlikely to be the only determinant for the occurrence and extent of sympathetic reinnervation.
authors.affiliation: Medizinische Poliklinik, Universität Würzburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Ludwig
authors.forename: B
authors.initials: B
authors.lastname: Friedgen
authors.forename: G
authors.initials: G
authors.lastname: Herrmann
authors.forename: R
authors.initials: R
authors.lastname: Zahorsky
authors.forename: G
authors.initials: G
authors.lastname: Inselmann
authors.forename: R
authors.initials: R
authors.lastname: Simon
authors.forename: K H
authors.initials: KH
authors.lastname: Graefe
authors.forename: U
authors.initials: U
authors.lastname: Nellessen
mesh_terms: D000328:Adult; D000368:Aged; D006321:Heart / Q000294:innervation*; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000097:blood; D008875:Middle Aged; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D008734:Methoxyhydroxyphenylglycol; C010117:3,4-dihydroxyphenylglycol