Optic neuritis: findings on MRI, CSF examination and HLA class II typing in 60 patients and results of a short-term follow-up.
Optic neuritis (ON) is a common first manifestation of multiple sclerosis (MS), and examination of patients with ON provides opportunities to study the early clinical stages of MS. This prospective study compares results of brain magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) examinations and HLA-Dw2 phenotyping in 60 consecutive patients with ON. At a median of 17 days after the onset of ON, 69% had oligoclonal IgG bands, and at a median on 79 days after onset, 53% had multiple (> or = 3) white matter lesions on MRI. Subgroup analyses revealed that MRI abnormalities and oligoclonal IgG bands were equally common in patients examined early or late after the onset of ON. Strong correlations were found between the presence of MRI abnormalities and oligoclonal IgG bands. The HLA-Dw2 phenotype was significantly increased in ON patients compared with controls, but also significantly different from a group of MS patients from the same geographical area. A significant relation was found between Dw2 phenotype and oligoclonal IgG bands. During a mean follow-up time of about 2 years, the diagnosis in 17 of the patients changed to clinically definite MS. Initially, 16 of them had oligoclonal IgG bands and 12 had three or more MRI lesions. Both MRI and CSF studies are important diagnostic tools in the workup of ON patients.
Söderström
M
M
Department of Ophthalmology, Karolinska Institute, Huddinge Hospital, Sweden.
Lindqvist
M
M
Hillert
J
J
Käll
T B
TB
Link
H
H
D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000134:cerebrospinal fluid*; D001921:Brain / Q000473:pathology*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis; D009902:Optic Neuritis / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000473:pathology*; D010641:Phenotype; D011446:Prospective Studies
D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D006681:HLA-D Antigens; D007074:Immunoglobulin G