title: Parotid function and composition of parotid saliva among elderly edentulous African-American diabetics.
abstract: This study examined parotid salivary flow rate and composition in three groups of differently treated diabetics and a control group of non-diabetics. The study population was composed of edentulous African-Americans at least 65 years of age. Group A was the control, Group B insulin-dependent (Regular Iletin, U-100 qd.), Group C controlled by oral medication (Tolbutamide, 500 mg qd.), and Group D was diet controlled. All diabetic patients had serum glucose values under 250 mg/dl. Salivary flow rates, secretory IgA, electrolytes (Na+, Cl-, K+, Ca++) and total protein concentrations were evaluated. The results showed no significant differences between groups with respect to salivary flow rates, electrolytes and IgA concentrations. Additionally, all diabetic groups demonstrated a significantly lower salivary total protein concentration when compared to the controls. There appears to be no evident decrease in salivary flow rate in these three differently controlled diabetic groups compared with healthy non-diabetics.
authors.affiliation: Epidemiology and Oral Disease Prevention Program, National Institute of Dental Research, NIH, Bethesda, Md 20892.
authors.forename: C F
authors.initials: CF
authors.lastname: Streckfus
authors.forename: S
authors.initials: S
authors.lastname: Marcus
authors.forename: S
authors.initials: S
authors.lastname: Welsh
authors.forename: R S
authors.initials: RS
authors.lastname: Brown
authors.forename: G
authors.initials: G
authors.lastname: Cherry-Peppers
authors.forename: R H
authors.initials: RH
authors.lastname: Brown
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015142:Baltimore; D044383:Black People; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology / Q000628:therapy; D004035:Diet Therapy; D004573:Electrolytes / Q000032:analysis; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D009066:Mouth, Edentulous; D010306:Parotid Gland / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012472:Salivation; D012636:Secretory Rate; D014044:Tolbutamide / Q000627:therapeutic use; D001741:Black or African American
chemical_list: D004573:Electrolytes; D007071:Immunoglobulin A, Secretory; D007328:Insulin; D012471:Salivary Proteins and Peptides; D014044:Tolbutamide