title: Hepatobiliary abnormalities on sonography in children with HIV infection.
abstract: Our purpose was to characterize the spectrum of hepatobiliary abnormalities on sonography in children with vertically transmitted HIV infection. Abdominal sonograms were performed on 41 children with HIV infection and correlated with clinical and histopathologic data. Hepatobiliary abnormalities were noted in 26 (63%) children. Hepatomegaly (n = 13) and abnormal hepatic echotexture (n = 13) were the most common abnormalities noted. Preexisting AIDS-related infections or neoplasms were noted significantly more frequently in children with hepatic or biliary abnormalities on sonography (18/26, 69%) than in children without abnormalities (5/15, 33%) (P = 0.0001). Most children with hepatobiliary abnormalities on sonography who underwent hepatic tissue sampling, however, did not have evidence of acute infection or neoplasia. Hepatobiliary abnormalities are frequently noted on sonography in children with HIV infection. Hepatomegaly and abnormal hepatic echotexture are the most frequent sonographic findings and are usually nonspecific.
authors.affiliation: Department of Diagnostic Imaging and Radiology, Children's National Medical Center, Washington, DC 20010.
authors.forename: C J
authors.initials: CJ
authors.lastname: Chung
authors.forename: C J
authors.initials: CJ
authors.lastname: Sivit
authors.forename: T A
authors.initials: TA
authors.lastname: Rakusan
authors.forename: R S
authors.initials: RS
authors.lastname: Chandra
authors.forename: M
authors.initials: M
authors.lastname: Ellaurie
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging; D001652:Bile Ducts / Q000000981:diagnostic imaging / Q000473:pathology; D001660:Biliary Tract Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000635:transmission; D006529:Hepatomegaly / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008107:Liver Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D014463:Ultrasonography