title: Saccadic lateropulsion in Wallenberg's syndrome may be caused by a functional lesion of the fastigial nucleus.
abstract: One of the clinical oculomotor hallmarks of lateral medullary infarction (Wallenberg's syndrome) is the so-called saccadic lateropulsion. In man and in animals, cerebellar lesions lead to dysmetric saccades and underline the importance of cerebellar control on saccadic accuracy. In order to study the lesion site responsible for saccadic lateropulsion we prospectively examined 12 patients with Wallenberg's syndrome who did not show a cerebellar lesion on CT or MRI. All patients consistently showed hypermetric saccades to the ipsilateral side and hypometric contralateral saccades comparable with the effects of cerebellar lesions in monkeys on saccadic accuracy. Based on the most recent experiments involving recordings from saccade-related neurons in the deep cerebellar nuclei of monkeys (oculo-motor region of fastigial nucleus), we hypothesize that saccadic lateropulsion in lateral medullary infarction is essentially identical with cerebellar saccadic dysmetria and results from a disruption of afferent olivocerebellar climbing fibres that gives rise to functional disinhibition of the cerebellar cortex and to increased inhibition of the deep cerebellar nuclei.
authors.affiliation: Neurologische Klinik, Ludwig-Maximilians-Universität München, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Helmchen
authors.forename: A
authors.initials: A
authors.lastname: Straube
authors.forename: U
authors.initials: U
authors.lastname: Büttner
mesh_terms: D000328:Adult; D000368:Aged; D002526:Cerebellar Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D002529:Cerebellar Nuclei / Q000503:physiopathology*; D004585:Electrooculography; D005133:Eye Movements; D005260:Female; D006801:Humans; D014854:Lateral Medullary Syndrome / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012438:Saccades