Use of supercritical CO2 for bone delipidation.
Supercritical carbon dioxide was used for bone delipidation. It appeared that this technology is very efficient since supercritical CO2 is able to diffuse into microporous solids much better than liquids and that it has a good solvent capacity for lipids. This extraction is the ideal first step of any bone processing because microporosity of bone tissue becomes much more accessible, which may enhance osteoconduction once implanted. Moreover, it is safe since it involves no toxic chemical and is potentially usable with allografts as well as xenografts.
Fages
J
J
Institut National des Sciences Appliquées, Département de génie biochimique et alimentaire, UA CNRS-540, Toulouse, France.
Marty
A
A
Delga
C
C
Condoret
J S
JS
Combes
D
D
Frayssinet
P
P
D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes; D016025:Bone Transplantation; D001842:Bone and Bones / Q000378:metabolism; D002245:Carbon Dioxide / Q000737:chemistry*; D002417:Cattle; D006861:Hydrogen Peroxide; D050356:Lipid Metabolism; D008854:Microscopy, Electron; D009926:Organ Preservation; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D009927:Tissue and Organ Procurement / Q000379:methods
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002245:Carbon Dioxide; D006861:Hydrogen Peroxide