Growth factors and hematopoietic recovery.
Availability of hematopoietic growth factors (GC-SF, GM-CSF, erythropoietin, etc.) has started a new arena of dose-intensification. The use of such growth factors has resulted in faster hematopoietic recovery of cancer patients and now offers several new treatment modifications. These include: (1)dose-intensification without hematopoietic stem cell support, (2) speedier hematopoietic recovery after hematoablative therapy and stem cell transplantation (allogeneic or autologous); (3) use of combination of growth factors, and (4) improvement in the delivery of anti-microbial drugs which are toxic towards hematopoietic cells (Gancyclovir, Bactrim, etc.). The above treatment strategies are under active clinical trials and can provide improved, cost-effective methods of treating patients with cancer.
Gulati
S C
SC
Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021.
Gopal
R
R
Prowda
J B
JB
Spanik
S
S
Jain
M
M
Gopal
A
A
D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
D016298:Hematopoietic Cell Growth Factors