(+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model.
Koch
K
K
Department of Immunology, Pfizer Inc., Groton, Connecticut 06340.
Melvin
L S
LS
Reiter
L A
LA
Biggers
M S
MS
Showell
H J
HJ
Griffiths
R J
RJ
Pettipher
E R
ER
Cheng
J B
JB
Milici
A J
AJ
Breslow
R
R
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003094:Collagen; D006168:Guinea Pigs; D006801:Humans; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009504:Neutrophils / Q000378:metabolism; D013329:Structure-Activity Relationship
D001578:Benzopyrans; D002264:Carboxylic Acids; D007975:Leukotriene B4; D003094:Collagen; C089698:CP 105696