Modeling eukaryotic transcriptional activation.
In recent years, many components involved in promoter-specific transcriptional activation in eukaryotes have been identified and characterized. We argue that a proper understanding of transcriptional activation will require quantitative modeling and we outline some of the considerations that such modeling will need to take into account.
Kingston
R E
RE
Department of Molecular Biology, Massachusetts General Hospital, Boston.
Green
M R
MR
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D005057:Eukaryotic Cells; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances; D008957:Models, Genetic; D008968:Molecular Conformation; D011387:Prokaryotic Cells; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation
D002843:Chromatin; D046911:Macromolecular Substances; D014157:Transcription Factors