title: Successful physostigmine treatment of acute dothiepin intoxication.
abstract: We report on a severe intoxication with the tricyclic antidepressant dothiepin. A treatment with a continuous infusion of physostigmine was successful and improved the ventricular arrhythmia. Dothiepin and its active metabolites were determined in plasma and urine by HPLC.
authors.affiliation: Drug Information Center, ABDA, Eschborn.
authors.forename: M
authors.initials: M
authors.lastname: Schulz
authors.forename: A
authors.initials: A
authors.lastname: Schmoldt
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004308:Dothiepin / Q000493:pharmacokinetics / Q000506:poisoning*; D005260:Female; D006801:Humans; D010830:Physostigmine / Q000627:therapeutic use*; D013406:Suicide, Attempted
chemical_list: D010830:Physostigmine; D004308:Dothiepin