Henoch-Schönlein purpura in rheumatoid arthritis.
This is the first report of Henoch-Schönlein purpura associated with permanent joint damage due to rheumatoid arthritis, which was observed in 3 of the 10 adults we treated for Henoch-Schönlein purpura since 1974. Each of 3 women had been admitted with palpable purpura of the lower extremities. The diagnosis was based on various findings including arthralgia, stiffness, and/or swelling of the joints, and on the results of radiographic, immunofluorescence and other studies. Renal biopsy revealed slight mesangial proliferation in 2 of the patients. The nephropathy did not deteriorate following discharge. However, bilateral swelling of the wrists with destructive joint changes was subsequently observed on radiographs in all patients. Since 2 patients showed positivity for human leukocyte antigen DR4, this antigen may have been a genetic factor in the joint disease in these patients.
Mitsuhashi
H
H
Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
Mitsuhashi
M
M
Tsukada
Y
Y
Yano
S
S
Naruse
T
T
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D014955:Wrist Joint / Q000000981:diagnostic imaging
D011239:Prednisolone