title: An attempt to screen asymptomatic women for ovarian and endometrial cancer with transvaginal color and pulsed Doppler sonography.
abstract: Several screening procedures have been proposed to detect ovarian and endometrial cancer. However, none of them is sensitive and specific enough to be used in population-based screening programs. During our 5 year long study, 5013 asymptomatic women (44% premenopausal and 56% postmenopausal women) were scanned by transvaginal color and pulsed Doppler ultrasonography in an attempt to detect malignancy. These women had 404 adnexal cysts; 70 had resolved spontaneously on follow-up scans and 18 persisted. Another 316 sonographically benign cysts are still in the procedure of follow-up second scans. Of 5013 women, four women had stage I ovarian carcinoma and six had stage I endometrial carcinoma. There was one false-positive case encountered with an endometrioma. Only 14 women were subjected to major operative intervention; others underwent minor procedures based on the benign scan findings. No medical or surgical complications were reported. Transvaginal color Doppler ultrasonography, a noninvasive procedure, can detect ovarian and endometrial carcinoma in asymptomatic women and may be used as a screening procedure for these diseases.
authors.affiliation: Ultrasonic Institute, Medical School, University of Zagreb Sveti Duh Hospital, Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Kurjak
authors.forename: H
authors.initials: H
authors.lastname: Shalan
authors.forename: S
authors.initials: S
authors.lastname: Kupesic
authors.forename: D
authors.initials: D
authors.lastname: Kosuta
authors.forename: A
authors.initials: A
authors.lastname: Sosic
authors.forename: S
authors.initials: S
authors.lastname: Benic
authors.forename: M
authors.initials: M
authors.lastname: Ilijas
authors.forename: S
authors.initials: S
authors.lastname: Jukic
authors.forename: M
authors.initials: M
authors.lastname: Predanic
mesh_terms: D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D010048:Ovarian Cysts / Q000000981:diagnostic imaging / Q000517:prevention & control; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000517:prevention & control*; D017698:Postmenopause; D017697:Premenopause; D015995:Prevalence; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color / Q000379:methods*