Development of vaccines against malaria.
Substantial progress towards development of a vaccine against Plasmodium falciparum malaria has been accomplished. A number of vaccine candidate antigens have been identified and in some of these antigens immunodominant B-cell and T-cell epitopes have been defined. New adjuvants and delivery systems suitable for human vaccines are available. The selection of suitable epitopes and their assembly in multi-antigenic constructs are research tasks for the future.
Berzins
K
K
Department of Immunology, Stockholm University, Sweden.
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000276:immunology*; D016052:Protozoan Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000953:Antigens, Protozoan; D016052:Protozoan Vaccines