title: [The periodic and regional characteristics of the pneumococcal serotype spectrum in children with respiratory diseases and in healthy carriers].
abstract: The aim of the work was the comparative study Streptococcus pneumoniae serotypes, isolated from healthy carriers and acute pneumonia patients in different regions of the CIS; in Moscow observations were carried out for 10 years. Specific antibodies to different S.pneumoniae capsular polysaccharide antigens were determined in blood serum samples by the method of heterogeneous enzyme immunoassay. The study revealed that S.pneumoniae serotype spectra in healthy children and in children with acute respiratory viral diseases were similar, while from pneumonia patients with complications of pleuritis caused by S.pneumoniae serotypes 1, 3, 5 and 14, were more frequently isolated. During 10 years of observations changes in the occurrence of individual serotypes were noted both in carriers and in patients. Differences in the serotype spectra of S.pneumoniae isolated in different regions were established. S.pneumoniae serotype 5 caused 70% of pleuritis cases in Tashkent, while rarely occurring in regions with the moderate climate. S.pneumoniae serotype 14, formerly causing complicated forms of pneumonia, lately became more widespread, but at the same time caused fewer cases of pneumonia with complications. High occurrence of pneumonia among children aged 1-3 years correlated with a low level of specific antibodies in the child population.
authors.forename: V K
authors.initials: VK
authors.lastname: Tatochenko
authors.forename: L K
authors.initials: LK
authors.lastname: Katosova
authors.forename: M A
authors.initials: MA
authors.lastname: Ulanova
authors.forename: A P
authors.initials: AP
authors.lastname: Baturo
authors.forename: A M
authors.initials: AM
authors.lastname: Fedorov
authors.forename: L N
authors.initials: LN
authors.lastname: Padiukov
authors.forename: V I
authors.initials: VI
authors.lastname: Shilko
authors.forename: V G
authors.initials: VG
authors.lastname: Ishutinova
authors.forename: S N
authors.initials: SN
authors.lastname: Boiarskiĭ
authors.forename: V K
authors.initials: VK
authors.lastname: Kozlov
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D000918:Antibody Specificity; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015994:Incidence; D007223:Infant; D010507:Periodicity; D010998:Pleurisy / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D011018:Pneumonia, Pneumococcal / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D012426:Russia / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial
vernacular_title: Peridodicheskie i regional'nye osobennosti serotipovogo spektra pnevmokokkov u deteĭ s respiratornymi zabolevaniiami i zdorovykh nositeleĭ.