title: The effect of dietary caffeine manipulation on blood caffeine, sleep and disturbed behaviour.
abstract: The effect of withdrawal of caffeine from the diet of a group of highly disturbed severely retarded adult patients was studied. Two weeks withdrawal produced no improvement in sleep pattern or behaviour, but re-introduction of normal diet was accompanied by a highly significant increase (P < 0.001) in ward disturbance ratings.
authors.affiliation: St Lawrence's Hospital, Caterham, Surrey, England.
authors.forename: G F
authors.initials: GF
authors.lastname: Searle
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects*; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000178:diet therapy* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012894:Sleep Stages / Q000187:drug effects*; D012919:Social Behavior
chemical_list: D002110:Caffeine