Therapeutic efficacy of recombinant human leukemia inhibitory factor in a primate model of radiation-induced marrow aplasia.
The therapeutic efficacy of recombinant human leukemia inhibitory factor (LIF) was examined in a nonhuman primate model of radiation-induced marrow aplasia. Rhesus monkeys received 450 cGy of total-body, 1:1 mixed neutron:gamma radiation. For 23 days thereafter, each monkey received a daily subcutaneous injection of LIF or human serum albumin (HSA) at a dose of 15 micrograms/kg body weight. Complete blood counts and white blood cell differentials were monitored for 60 days postirradiation. Administration of LIF significantly decreased (P < or = .05) the duration of thrombocytopenia (platelet count < 30,000 or 20,000/microL), ie, 9.3 days or 6.3 days, respectively, versus the HSA-treated control monkeys, 12.2 days or 10.2 days, respectively. Treatment with LIF did not alter the duration of neutropenia (absolute neutrophil count < 1,000/microL) as compared with the HSA-treated control monkeys. Cytokine administration did not exacerbate the radiation-induced anemia observed in the HSA-treated control monkeys.
Farese
A M
AM
Armed Forces Radiobiology, Research Institute, Bethesda, MD 20889-5603.
Myers
L A
LA
MacVittie
T J
TJ
D000741:Anemia, Aplastic / Q000209:etiology / Q000628:therapy*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006131:Growth Inhibitors / Q000627:therapeutic use*; D006410:Hematopoiesis / Q000187:drug effects; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000627:therapeutic use*; D008253:Macaca mulatta; D008297:Male; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use*; D012709:Serum Albumin / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy*
D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D011993:Recombinant Fusion Proteins; D012709:Serum Albumin