title: Advances in understanding cytomegalovirus infection after transplantation.
abstract: Susceptibility to infection and disease caused by CMV varies with the degree of immunosuppression, the antecedent immunity to CMV, the source of the virus, and a complex set of host responses. These responses include the development of humoral and cellular immunity and also immunopathologic responses. HLA-restricted responses may facilitate CMV disease by facilitating the survival and activation of latently infected cells, or by facilitating MHC-class I or class II cellular immune responses underlying both protective effects and pathologic inflammation.
authors.affiliation: Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
authors.forename: M
authors.initials: M
authors.lastname: Ho
mesh_terms: D003587:Cytomegalovirus / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000276:immunology / Q000821:virology; D004198:Disease Susceptibility; D006801:Humans; D016377:Organ Transplantation / Q000009:adverse effects*; D012307:Risk Factors