title: The cytochrome oxidase superfamily of redox-driven proton pumps.
abstract: Most respiratory oxidases of eukaryotic and prokaryotic organisms are members of a superfamily of enzymes that couple the redox energy available from the reduction of molecular oxygen to the mechanism of pumping protons across the membrane. The recent applications of site-directed mutagenesis and of a variety of spectroscopic techniques have allowed major advances in our understanding of the structure and function of these proteins.
authors.affiliation: School of Chemical Sciences, University of Illinois, Urbana 61801.
authors.forename: M W
authors.initials: MW
authors.lastname: Calhoun
authors.forename: J W
authors.initials: JW
authors.lastname: Thomas
authors.forename: R B
authors.initials: RB
authors.lastname: Gennis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003576:Electron Transport Complex IV / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008670:Metals / Q000737:chemistry; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D010084:Oxidation-Reduction; D017494:Proton Pumps / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: D008670:Metals; D017494:Proton Pumps; D003576:Electron Transport Complex IV