Serum fatty acid profiles in type I and type II diabetes: metabolic alterations of fatty acids of the main serum lipids.
Fatty acid profiles of various lipid fractions were determined in carefully selected insulin-dependent and non-insulin-dependent diabetics to assess relationships between serum fatty acid composition and type of diabetes. Clear-cut hypertriglyceridemia with slight hypercholesterolemia was found in both diabetic types. The decrease of lignoceric acid in sphingomyelin is the only alteration found in both types of diabetes. In the insulin-dependent diabetics, there were increases in levels of oleic acid and of alpha-linolenic acid in esterified cholesterol, and in levels of alpha-linolenic acid in the triglyceride fraction. In the non-insulin-dependent diabetics, there were increases in levels of oleic acid and total monounsaturated fatty acids in the triglyceride fraction and there was an increase in levels of saturated fatty acids and a decrease in levels of polyunsaturated acids in phosphatidylcholine; in sphingomyelin, dihomogamma-linoleic acid levels were enhanced. Arachidonic acid levels were normal in our patient population.
Seigneur
M
M
Laboratoire d'Hémobiologie, Hôpital Cardiologique, Pessac-Bordeaux, France.
Freyburger
G
G
Gin
H
H
Claverie
M
M
Lardeau
D
D
Lacape
G
G
Le Moigne
F
F
Crockett
R
R
Boisseau
M R
MR
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood; D013109:Sphingomyelins / Q000097:blood; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D010713:Phosphatidylcholines; D013109:Sphingomyelins; D014280:Triglycerides; D002784:Cholesterol