title: Lignans from the wood of Abies pinsapo.
abstract: Several lignans have been isolated from the CHCl3 extract of the wood of Abies pinsapo. These include the new compounds 4,4',9-trihydroxy-3,3'-dimethoxy-9,9'-epoxylignan [2], (9'R)-9'-hydroxylariciresinol [5], and (7'R)-7'-hydroxylariciresinol [7], as well as a novel sesquilignan with the structure (8R,8'R,8"R,9R)-4',4",9,9"-tetrahydroxy-3,3',3"-trimethoxy-4,8":.9, 9'-bis-epoxy-8,8'-sesquineolignan [8], to which we have assigned the trivial name sesquipinsapol C. Compound 2 has been identified as a mixture of epimers, while compounds 5, 7, and 8 were obtained their acetoxyl derivatives. The new structures were established by spectroscopic methods and chemical transformations. Certain antimicrobial and cytotoxic activity assays have been carried out and applied to the isolates from A. pinsapo.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Spain.
authors.forename: A F
authors.initials: AF
authors.lastname: Barrero
authors.forename: A
authors.initials: A
authors.lastname: Haïdour
authors.forename: M
authors.initials: M
authors.lastname: Muñoz Dorado
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts