title: Studies on congenital hereditary cataract and microphthalmia of the miniature schnauzer dog.
abstract: Hereditary cataract in dogs occurs as an autosomal recessive trait. The opacity is primarily in the lens nucleus and posterior cortex. The affected animals also have other ocular abnormalities such as microphthalmia. To understand the genetic basis of this disorder, we have analyzed leukocyte DNA from affected and normal dogs for possible mutations in the homeobox containing gene and myotonic dystrophy locus. The results show that there are no signs of microdeletion, insertion, point mutation and rearrangements in these loci. Although these observations cannot completely rule out the possibility of point mutations, they suggest that the above loci are unlikely to be associated with the disease.
authors.affiliation: Eye Research Institute of Oakland University, Rochester, MI 48309.
authors.forename: B S
authors.initials: BS
authors.lastname: Shastry
authors.forename: V N
authors.initials: VN
authors.lastname: Reddy
mesh_terms: D000818:Animals; D015783:Aniridia / Q000235:genetics; D001483:Base Sequence; D002386:Cataract / Q000235:genetics / Q000662:veterinary*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D017931:DNA Primers; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008850:Microphthalmos / Q000235:genetics / Q000662:veterinary*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D017931:DNA Primers; D004247:DNA