Age-related decrease in the naive (OX22+) T cells in F344 rats.
The frequency of the cells bearing the naive marker (OX22+) in T cells, helper, and cytotoxic/suppressor T cell subsets isolated from the spleens of young and old F344 rats were measured by flow cytometry. The percentage of naive cells in T cells decreased significantly with age and this decline occurred primarily in the helper subset.
Pahlavani
M A
MA
GRECC (182), Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas 78284.
Richardson
A
A
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D017252:CD3 Complex / Q000378:metabolism; D005434:Flow Cytometry; D018655:Lymphocyte Count; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000378:metabolism
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D017252:CD3 Complex