[Concentrations of kininogen and prekallikrein in plasma and activity of plasma renin depending on the type of blood pressure response to captopril in patients with arterial hypertension].
The dynamics was analysed of changes of arterial blood pressure, plasma kininogen and prekallikrein concentrations and plasma renin activity (PRA) in 50 patients with arterial hypertension, in relation to the type of blood pressure response to captopril. It was shown that after three weeks of treatment with captopril 150 mg daily, in 23 patients (46%) normalization of systolic and diastolic blood pressure occurred, and in 27 patients (54%), despite a significant reduction, blood pressure normalization was not achieved. In both groups of patients a significant decrease of plasma kininogen concentration and an increase of plasma prekallikrein level were found, indicating kininogenase activation and PRA increase. However, only in patients with arterial blood pressure normalization, a return of kininogen concentration to normal value was observed and a twofold increase of PRA in relation to the initial value was noted. Our studies indicate that in patients with arterial hypertension treated with captopril a correlation appears between the changes of plasma kinin system and PRA which determines the mode of blood pressure reaction to captopril.
Zebrowska-Lupina
I
I
Kliniki Kardiologii Ak. Med. w Lublinie.
Kolber-Postepska
B
B
Markiewicz
M
M
Horubała-Bielak
G
G
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007704:Kininogens / Q000097:blood*; D008875:Middle Aged; D011288:Prekallikrein / Q000032:analysis*; D012083:Renin / Q000097:blood*
D007704:Kininogens; D011288:Prekallikrein; D002216:Captopril; D012083:Renin
Stezenie kininogenu i prekalikreiny w osoczu oraz aktywność reninowa osocza w zalezności od rodzaju odpowiedzi ciśnienia na kaptopryl u chorych na nadciśnienie tetnicze.