The role of parathyroid hormone-related protein in calcium homeostasis in the fetal pig.
The concentrations of plasma parathyroid hormone-like bioactivity and parathyroid hormone-related protein (1-86) (PTHrP) immunoreactivity were both higher in fetal pigs than in their mothers during the last 3 weeks of gestation. Both activities changed inversely with alterations in the plasma ionized calcium concentration. The data suggest that PTHrP may have a role in calcium homeostasis in the fetal pig, similar to its postulated role in sheep in the stimulation of calcium transport across the placenta.
Abbas
S K
SK
Institute of Biological Sciences, University of Wales Aberystwyth, Penglais.
Ratcliffe
W A
WA
Moniz
C
C
Dixit
M
M
Caple
I W
IW
Silver
M
M
Fowden
A
A
Care
A D
AD
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism*; D006706:Homeostasis; D006934:Hypercalcemia / Q000139:chemically induced*; D017136:Ion Transport; D010281:Parathyroid Hormone / Q000097:blood*; D044162:Parathyroid Hormone-Related Protein; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism*; D013552:Swine
D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D004492:Edetic Acid; D002118:Calcium