Analysis of calcium channel blocking dihydropyridines and their degradation products by gas chromatography.
Seven dihydropyridine calcium blockers have been analyzed by GC. Simultaneous analysis has been performed both by an isothermal and a gradient method. Moreover, the proposed methods have been performed on the analysis of daylight exposed methanolic solutions of considered compounds; the ability of the systems in separate original compounds from daylight degradation products has been studied. The GC-MC spectra of photodegradation products are discussed.
Barbato
F
F
Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università di Napoli Federico II, Italy.
Grumetto
L
L
Morrica
P
P
D002121:Calcium Channel Blockers / Q000032:analysis*; D002849:Chromatography, Gas; D013058:Mass Spectrometry
D002121:Calcium Channel Blockers