Biocompatibility of xenogeneic bone, commercially available coral, a bioceramic and tissue sealant for human osteoblasts.
The drawbacks of freshly harvested autologous bone have resulted in the search for an alternative, capable of supporting osteogenic cell growth. This capability was examined in potential bone graft materials by culturing human osteoblasts on each material. Test materials included rat bone, Surgibone, Ostilit, Biocoral and Tisseel. After 3 days osteoblasts had adhered to all materials, except Ostilit. With increasing time the cells multiplied on the materials, to varying extents. Cell affinity was greatest for rat bone and Tisseel. Fewer cells attached to Biocoral and Surgibone. Thus all the materials, with the exception of Ostilit, were biocompatible for human osteoblasts.
Doherty
M J
MJ
School of Clinical Medicine/Orthopaedic Surgery, Queen's University of Belfast, UK.
Schlag
G
G
Schwarz
N
N
Mollan
R A
RA
Nolan
P C
PC
Wilson
D J
DJ
D000818:Animals; D018786:Bone Substitutes; D016025:Bone Transplantation; D002119:Calcium Carbonate; D002448:Cell Adhesion; D002478:Cells, Cultured; D002516:Ceramics; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts; D051381:Rats
D018786:Bone Substitutes; D002119:Calcium Carbonate