title: Multiple nevoid spiradenomas.
abstract: This report delineates a new clinical presentation of multiple benign spiradenoma (BS), a diffuse linear nevoid pattern. A 16-year-old girl, in otherwise good health, had many papulonodular lesions, varying in color from blue-gray to bright red, disposed linearly on the right half of her body, involving the periorbital region, cheek, lateral side of the neck, trunk, linea alba, right thigh, and leg. Only a few nodules were slightly painful. Lesions were reported to be present at birth; no family members had similar lesions, either in solitary or multiple form. Excisional biopsies of three lesions from the neck, abdomen, and leg, respectively, were performed; histologically, all three samples showed a picture of BS. In some areas, the tumor was directly connected to a pilosebaceous unit. Furthermore, a focal area with pilar differentiation at the periphery of the lobules was observed, which might suggest that BS can differentiate toward various cutaneous adnexal structures. Our patient probably is the first one reported with diffuse linear nevoid lesions of BS, present at birth and involving the right half of the body.
authors.affiliation: Institute of Experimental Dermatology, University of Palermo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Noto
authors.forename: M R
authors.initials: MR
authors.lastname: Bongiorno
authors.forename: G
authors.initials: G
authors.lastname: Pravatà
authors.forename: M
authors.initials: M
authors.lastname: Aricò
mesh_terms: D006607:Adenoma, Sweat Gland / Q000473:pathology*; D000293:Adolescent; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology*