Combined factor and QSAR analysis for antibacterial and pharmacokinetic data from parallel biological measurements.
Antibacterial potency data for a variety of bacterial strains and pharmacokinetic parameters of naphthyridines taken from the literature were submitted to factor and QSAR analyses. Factor analysis of antibacterial potencies unraveled a distinct data structure. The information obtained about the internal relatedness of tests can be used in QSAR analyses and reflects itself in the QSAR results. Factor analysis of pharmacokinetic data also led to a clear grouping of measurements with a strong relationship of half life time and urinary recovery, respectively, with log D.
Franke
R
R
Institute of Medical Microbiology, Humboldt-University, Berlin.
Gruska
A
A
Presber
W
W
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D009287:Naphthyridines / Q000493:pharmacokinetics* / Q000494:pharmacology*; D012984:Software; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D009287:Naphthyridines