Changes in the male rat hepatic cytochrome P-450 level, heme oxygenase and delta-aminolevulinic acid synthase activities at various stages of life.
delta-Aminolevulinic acid synthase and heme oxygenase are closely functionally connected with the hepatic microsomal mixed function oxydase system. There is a wide range of changes in microsomal heme oxygenase activity, cytochrome P-450 level and mitochondrial delta-aminolevulinic acid synthase activity in rat livers at various stages of life. We tried to investigate the spontaneous phases of these enzymatic protein activities and the levels of cytochrome P-450 as a function of age. We noted that each of these proteins change their activity and level very characteristically during the rats' lifetime. However, correlations between heme oxygenase activity, delta-aminolevulinic acid synthase activity and cytochrome P-450 levels still need to be investigated to elucidate the mechanism of these connections.
Plewka
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Department of Histology & Embryology, Silesian School of Medicine, Katowice-Ligota, Poland.
Bienioszek
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Plewka
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D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D003577:Cytochrome P-450 Enzyme System; D006419:Heme Oxygenase (Decyclizing); D000624:5-Aminolevulinate Synthetase