[Effects of dingduwan on electric activities of gastrointestinal smooth muscle and effect of gastrointestinal motility].
Dingduwan (DDW) is a Chinese herbal medicine. Method of modified synchronous recording was used to study the electric activities of gastrointestinal (GI) smooth muscle and the effect of GI motility treated by DDW. A dosage of 3.5 g/kg for ingestion in rats markedly increased the average amplitude of GI slow wave, the total amplitude of GI motion, the rate of GI slow wave and intestinal motion (P < 0.05), but it had no significant effects on the frequency of gastroelectric slow wave and gastric motility (P < 0.05). DDW in the dosage of 5.2 g/kg for ingestion markedly promoted the recovery of intestinal intussusception in mice (P > 0.05). The results showed that DDW markedly increased the intestinal electricity and motility more than that of stomach.
Sun
S S
SS
Capital Medical University, Beijing.
Yuan
S Q
SQ
Tang
Y
Y
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004594:Electrophysiology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007422:Intestines / Q000502:physiology; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000502:physiology*; D051381:Rats; D013270:Stomach / Q000502:physiology
D004365:Drugs, Chinese Herbal