8-Hydroxypenillic acid: NMR characteristics and facile formation from 6-aminopenicillanic acid.
High field NMR (1H and 13C) spectral characteristics in D2O of 8-hydroxypenillic acid and 6-aminopenicillanic acid (6-APA)-sodium bicarbonate mixtures are reported. The ready conversion of 6-APA to 8-hydroxypenillic acid is demonstrated.
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School of Pharmacy and Pharmacology, University of Bath, UK.
Lipczynski
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D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry*
D007093:Imidazoles; D013844:Thiazoles; C089999:8-hydroxypenillic acid; D010397:Penicillanic Acid; C004408:aminopenicillanic acid