The effect of phosphate supplementation on linear growth in children with X-linked hypophosphatemia.
BACKGROUND
X-linked hypophosphatemia is the most common inherited cause of rickets. Current therapy for this disorder includes vitamin D and phosphate supplementation; however, phosphate therapy has been associated with nephrocalcinosis. The purpose of this study is to evaluate the effect of oral phosphate therapy on growth in patients with X-linked hypophosphatemia treated with either calcitriol or dihydrotachysterol (vitamin D).


METHODS
We retrospectively evaluated the prepubertal growth of 36 children with X-linked hypophosphatemia. The height standard deviation score (Z-score) of patients initially treated with vitamin D alone and the Z-scores of patients treated with vitamin D and phosphate therapy were compared. In addition, the growth of therapy were compared. In addition, the growth of patients treated with vitamin D was compared with that of patients treated with vitamin D and phosphate from the outset of therapy.


RESULTS
Patients treated with vitamin D alone for 5.36 +/- 2.18 years had an improvement in Z-score from -3.1 +/- 1.10 to -2.49 +/- 0.66 SDS, P < .05. Adding phosphate therapy for patients initially treated with vitamin D alone for 4.83 +/- 2.99 years did not further improve Z-score (-2.49 +/- 0.66 vs -2.35 +/- 0.83). Initial therapy with vitamin D and phosphate for 4.33 +/- 2.19 years also improved Z-score, (-2.84 +/- 1.02 vs -1.98 +/- 0.82, P < .05). The change in Z-score was similar to the group treated with vitamin D alone compared with the group treated initially with vitamin D and phosphate (0.65 +/- 0.54 vs 0.85 +/- 0.65, respectively).


CONCLUSIONS
These data demonstrate that both vitamin D alone and in combination with phosphate improved linear growth. Adding oral phosphate for children initially treated with vitamin D alone did not improve Z-score. Initial therapy with vitamin D and vitamin D plus phosphate produced similar changes in linear growth.
Seikaly
M G
MG
Department of Pediatrics, University of Texas Southwestern Medical School, Dallas.
Browne
R H
RH
Baum
M
M
D000284:Administration, Oral; D002117:Calcitriol / Q000627:therapeutic use*; D002675:Child, Preschool; D004097:Dihydrotachysterol / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006130:Growth Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000150:complications*; D010710:Phosphates / Q000097:blood / Q000627:therapeutic use*; D012189:Retrospective Studies; D012720:Severity of Illness Index
D010710:Phosphates; D002117:Calcitriol; D004097:Dihydrotachysterol