[The role of investigating the fractional composition of high-density cholesterol lipoproteins and dys-alpha-lipoproteinemia for detection of atherogenic disorders].
Disorders of cholesterol-acceptor and cholesterol-transporting properties of antiatherogenic lipoproteins are associated with changes in etherification and fractional composition of high-density lipoprotein (HDLP) cholesterol. The said metabolic shifts prompted us to develop a new method for assessment of the cholesterol coefficient of plasma lipoprotein spectrum atherogenicity calculated by the formula: (CS--alpha-CS)/alpha-CS.(ECS/FCS), where alpha-CS, ECS, and FCS are total, ether-bound, and free HDLP cholesterols, respectively. For detection of atherogenic disorders assessment of HDLP loading with ether-bound cholesterol is recommended, as well as of dyslipoproteinemia, from the ratio of atherogenic lipoproteins and HDLP2, of lipoprotein cholesterols of these two classes, and of the type and severity of dys-alpha-lipoproteinemia from HDLP2/HDLP3 ratio. A reduced value of this ratio is a sensitive indicator of disorders in antiatherogenesis metabolic system leading to impaired cholesterol outflow from the tissues. Efficacy of diagnosis of atherosclerosis by each of the suggested methods is higher than that of the prototype method. Authors' certificates for invention of these methods were granted.
Kamyshnikov
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D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood / Q000175:diagnosis*; D008076:Cholesterol, HDL / Q000097:blood*; D005069:Evaluation Studies as Topic; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged
D008076:Cholesterol, HDL; D008074:Lipoproteins
Znachenie issledovaniia fraktsionnogo sostava kholesterina lipoproteinov vysokoĭ plotnosti i dis-al'fa-lipoproteinemii dlia vyiavleniia aterogennykh narusheniĭ.