The requirement for a retinoic acid lactone of 11-cis, 13-cis-stereochemistry for topical dermatologic activity.
Lewin
A H
AH
Research Triangle Institute, North Carolina 27709.
Goehring
R R
RR
Zusi
F C
FC
Gendimenico
G J
GJ
Nair
X
X
Whitting
G
G
Bouquin
P
P
Tetrault
G
G
Carroll
F I
FI
D000287:Administration, Topical; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D005260:Female; D007642:Keratosis / Q000517:prevention & control; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D065108:Ornithine Decarboxylase Inhibitors; D012867:Skin / Q000187:drug effects* / Q000201:enzymology; D013329:Structure-Activity Relationship; D014212:Tretinoin / Q000737:chemistry / Q000494:pharmacology*
D007783:Lactones; D065108:Ornithine Decarboxylase Inhibitors; D014212:Tretinoin; D004247:DNA