Immunohistochemical localization of insulin-like growth factor 1 receptors in benign and malignant tissues of the female genital tract.
The distribution of insulin-like growth factor I (IGF-1) receptors in the female genital tract was examined by immunohistochemistry. The monoclonal antibody alpha-IR-3, which binds to the alpha-subunits of the IGF-1 receptor, was used for specific binding and the peroxidase-antiperoxidase method was used for staining. IGF-1 receptors were consistently detected in the epithelium of cervix, endometrium and the fallopian tube. Furthermore, high expression of the IGF-1 receptors was found in ovarian cancer tissue, where predominantly the stromal cells around the vessels gave an intense staining. Since the expression of the IGF-1 receptors in tumor epithelium was only weak and inconsistent, it is tempting to speculate that the stromal compartment in ovarian cancer is the target tissue for the effects of IGF-1.
Weigang
B
B
Department of Obstetrics and Gynecology, University of Erlangen-Nuremberg, Germany.
Nap
M
M
Bittl
A
A
Jaeger
W
W
D002462:Cell Membrane / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D005833:Genital Neoplasms, Female / Q000737:chemistry / Q000648:ultrastructure*; D005836:Genitalia, Female / Q000737:chemistry / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D017526:Receptor, IGF Type 1 / Q000032:analysis* / Q000276:immunology
D017526:Receptor, IGF Type 1