title: The activity of epitestosterone in hormone dependent prostate tumour models.
abstract: Epitestosterone has been shown previously to counteract the testosterone activity in some experimental models. In the present study the activity of epitestosterone in an in vitro model of human LNCaP/FCS prostate cells and in vitro in Dunning R 3327-GH rat prostate carcinoma was tested. In LNCaP/FGC cells cultivated with fetal calf serum (FCS) treated with dextran-coated charcoal epitestosterone displayed rather androgenic than antiandrogenic properties, whereas the cultivation with native FCS resulted in a very weak inhibition of tumour cell growth with epitestosterone in higher concentration. The growth of Dunning R 3327-GH carcinoma of prostate was very weakly enhanced by epitestosterone alone as late as at the end of the 5-week experiment. Epitestosterone did not significantly inhibit the testosterone stimulated tumour growth.
authors.affiliation: Institut für Pharmazie, Universität Regensburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Maucher
authors.forename: E
authors.initials: E
authors.lastname: von Angerer
authors.forename: R
authors.initials: R
authors.lastname: Hampl
authors.forename: L
authors.initials: L
authors.lastname: Stárka
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000601:surgery; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004195:Disease Models, Animal; D004845:Epitestosterone / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000601:surgery; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D051381:Rats; D011916:Rats, Inbred F344; D013739:Testosterone / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D013739:Testosterone; D004845:Epitestosterone