title: Loin pain-hematuria syndrome with a distinctive vascular lesion and alternative pathway complement activation.
abstract: We describe a 48-year-old woman with loin pain-hematuria syndrome. Her renal abnormalities included conspicuous microaneurysmal and glomeruloid (plexiform) angiomatous changes. The deposition of both properdin and the C5b-9 complex, as well as the usual C3, in arterioles argues for complement activation. To our knowledge, neither of these features has been previously described. We speculate about the cause of loin pain-hematuria syndrome and note the uncommonness of this entity in the United States as opposed to Great Britain.
authors.affiliation: Department of Pathology, School of Medicine, State University of New York-Stony Brook 11794-8691.
authors.forename: F
authors.initials: F
authors.lastname: Miller
authors.forename: B P
authors.initials: BP
authors.lastname: Lane
authors.forename: M
authors.initials: M
authors.lastname: Kirsch
authors.forename: E
authors.initials: E
authors.lastname: Ilamathi
authors.forename: B
authors.initials: B
authors.lastname: Moore
authors.forename: M
authors.initials: M
authors.lastname: Finger
mesh_terms: D003170:Complement Pathway, Alternative; D005260:Female; D006417:Hematuria / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000098:blood supply / Q000473:pathology; D017116:Low Back Pain / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D013577:Syndrome