The epidemiology of non-Hodgkin's lymphoma: why the increased incidence?
The incidence of non-Hodgkin's lymphoma continues to increase in the United States. Improvements in diagnostic techniques, changes in disease classifications, and the increase in AIDS-related lymphomas account for only a small percentage of the increase, leaving most of the increased incidence unexplained. Viruses clearly play a major role in the pathogenesis of some subtypes of non-Hodgkin's lymphoma, especially Epstein-Barr virus and HTLV-1, and improvements in molecular diagnostic techniques may identify additional viruses that have a role in the pathogenesis of lymphomas. Immunodeficiencies, whether acquired, congenital, or iatrogenic, clearly predispose to the development of non-Hodgkin's lymphoma. Numerous environmental exposures have also been linked to an increased risk of non-Hodgkin's lymphoma and may account for a portion of the continuing increased incidence of the disease.
Palackdharry
C S
CS
Medical College of Ohio, Toledo.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D004781:Environmental Exposure / Q000009:adverse effects; D006202:Hair Dyes / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects; D010575:Pesticides / Q000009:adverse effects; D012307:Risk Factors; D014777:Virus Diseases / Q000150:complications
D006202:Hair Dyes; D010575:Pesticides