Antiethanol effects of indol-3-ylpyruvic acid in mice.
Indol-3-ylpyruvic acid (IPA, 10-100 mg/kg), an endogenous metabolite of tryptophan, shortened ethanol anaesthesia in C57Bl/6 male mice and diminished the post-ethanol (23 hr) inhibition of locomotion. In an elevated plus-maze, IPA had an anxiolytic effect in short-sleep, but not in long-sleep, mice. IPA did not modify ethanol-induced or caffeine-induced stimulation of spontaneous locomotion or the anxiogenic effect of pentylenetetrazole in an elevated plus-maze. The probable involvement of IPA in the defence mechanisms in alcoholism is suggested.
Lapin
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Laboratory of Psychopharmacology, Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia.
Politi
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D000428:Alcohol Drinking / Q000009:adverse effects; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D004644:Emotions / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D010433:Pentylenetetrazole / Q000494:pharmacology; D012894:Sleep Stages / Q000187:drug effects*
D000927:Anticonvulsants; D007211:Indoles; D000431:Ethanol; C008122:indol-3-yl pyruvic acid; D010433:Pentylenetetrazole