title: The thermoregulation of halothane versus isoflurane in humans receiving ophthalmological surgery.
abstract: Although suppression of thermoregulatory mechanisms during anaesthesia is generally assumed, the extent to which thermoregulation may be inactive is unknown. Twenty unpremedicated, ASA physical status class I patients (17 men and 3 women) scheduled for retinal detachment surgery were studied to evaluate the different changes of core and two skin-surface temperatures during halothane or isoflurane anaesthesia. Anaesthesia was induced by mask inhalation of halothane or isoflurane in nitrous oxide 70% and oxygen and was maintained by mechanical ventilation during surgery with halothane or isoflurane in nitrous oxide 50% and oxygen only. Core temperature (rectus) and skin-surface temperatures (forearm and fingertip) were measured during surgery using three separate thermometers (Y.S.I.: Yellow springs instrument Co., Inc. G541-211-Y01-33A0). Operating room temperatures were recorded in every case. Significant vasoconstriction was prospectively defined by a skin-surface temperature gradient between two sampling sites > or = 4 degrees C. The result indicated that there was no significant difference between core temperatures and skin-surface temperature gradients during halothane anaesthesia and isoflurane anaesthesia. However, three of the ten patients had their skin-surface temperature gradients > or = 4 degrees C in the halothane group. None of the ten patients had their skin-surface temperature gradients > or = 4 degrees C in the isoflurane group.
authors.affiliation: Department of Anesthesiology, Chang Gung Memorial Hospital, Taipei.
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.forename: R S
authors.initials: RS
authors.lastname: Wu
authors.forename: W J
authors.initials: WJ
authors.lastname: Cheng
authors.forename: H C
authors.initials: HC
authors.lastname: Chen
authors.forename: P P
authors.initials: PP
authors.lastname: Tan
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012163:Retinal Detachment / Q000503:physiopathology / Q000601:surgery*
chemical_list: D007530:Isoflurane; D006221:Halothane