title: Renal vascular effects of epinephrine infusion in the halothane-anesthetized piglet.
abstract: The objective of this study was to determine the dose-response effects of epinephrine, given by systemic intravenous infusion to the halothane-anesthetized newborn piglet, on renal blood flow, mean arterial blood pressure, and renal vascular resistance. Seven newborn piglets were acutely instrumented. A transit-time ultrasound flow probe was placed around the renal artery and a femoral arterial catheter was placed for blood pressure monitoring. Epinephrine was infused in doubling doses from 0.2 to 3.2 micrograms.kg-1.min-1. Mean arterial blood pressure increased from 54 mmHg (1 mmHg = 133.3 Pa) to an average of 96 mmHg at 3.2 micrograms.kg-1.min-1 of epinephrine. Renal blood flow increased from 165 mL.min-1 x 100 g-1 at baseline to 185 mL.min-1 x 100 g-1 at a dose of 0.2 microgram.kg-1.min-1 and increased further at 0.4 and 0.8 micrograms.kg-1.min-1 to reach 261 mL.min-1 x 100 g-1. Renal blood flow began to fall at a dose of 3.2 micrograms.kg-1.min-1, remaining however, significantly above baseline (211 mL.min-1 x 100 g-1). Consequently, calculated renal vascular resistance fell as the dose was increased from 0.2 to 0.8 micrograms.kg-1.min-1 and then rose again at 1.6 and 3.2 micrograms.kg-1.min-1, being significantly above baseline at 3.2 micrograms.kg-1.min-1. These results demonstrate that epinephrine when given by systemic infusion to the halothane-anesthetized newborn pig is a renal vasodilator at low doses and causes renal vasoconstriction at moderate to high doses. Renal blood flow remained above baseline at all doses tested, and thus, within the dosage range tested, epinephrine infusion should not cause renal ischemia.
authors.affiliation: University of Alberta, Department of Pediatrics, Edmonton, Canada.
authors.forename: K J
authors.initials: KJ
authors.lastname: Barrington
authors.forename: R G
authors.initials: RG
authors.lastname: Allen
authors.forename: J W
authors.initials: JW
authors.lastname: Dewald
mesh_terms: D000758:Anesthesia; D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006221:Halothane; D008297:Male; D012079:Renal Circulation / Q000187:drug effects*; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D006221:Halothane; D004837:Epinephrine