[The procollagen-III peptide in the clinical surveillance of alcoholic hepatopathy and other chronic hepatopathies].
Liver fibrosis determines the course and prognosis of alcoholic liver disease. Evaluation of serum concentration of procollagen-III peptides (sPIIIP) is considered a biochemical test useful for evaluating a fibrotic process. We have investigated 30 healthy subjects and 53 patients with alcoholic liver disease, histologically diagnosed by percutaneous liver biopsy in four clusters: steatosis (11), fibrosteatosis (11), chronic active hepatitis (11) and cirrhosis (20). SPIIIP levels were increased in patients with cirrhosis and chronic active hepatitis; while they were regular in patients with steatosis and fibrosteatosis. Evaluation of serum concentration of sPIIIP by radioimmunoassay seems to be an useful test for identifying patients with alcoholic liver disease with a good prognosis and patients in progress to cirrhosis and it is an useful test for control the course and evolution of chronic liver disease.
Pagani
A
A
Divisione di Medicina Generale 2, USSL 34, Chiari-Rovato, Brescia.
Pranzo
A
A
Sala
N
N
Galante
T
T
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001707:Biopsy, Needle; D002908:Chronic Disease; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000097:blood* / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D012680:Sensitivity and Specificity
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide
Il peptide del procollagene-III nella sorveglianza clinica dell'epatopatia alcolica e di altre epatopatie croniche.