title: [Evaluation of a new nitric oxide delivery system during mechanical ventilation].
abstract: A new nitric oxide delivery and continuous monitoring system is described. During mechanical ventilation, this new system connected with Siemens Servo 900C ventilator was shown to be able to provide a constant inspired NO concentration (10-100 ppm) using chemiluminescence technique for NO analysis. Gas was analysed at the mixing chamber in front of the ventilator inlet and inspiratory tube connected with the soda-lime carbon-dioxide absorber. Both NO concentrations showed a good correlation (r = 0.99). The actual NO concentration from the NO supply cylinder was 1154 ppm and NO2 concentration was 14 ppm. In mongrel dogs, after 20 minutes of NO inhalation (10-100 ppm), the blood methemoglobin level reached a peak value of 2.2% starting from the pre-inhalation level of 0%. To optimize the safety of the clinical application of NO, its concentration should be measured continuously with chemiluminescence technique.
authors.affiliation: Intensive Care Unit, Oita Medical University Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: H
authors.initials: H
authors.lastname: Miyakawa
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Kitano
authors.forename: H
authors.initials: H
authors.lastname: Iwasaka
authors.forename: S
authors.initials: S
authors.lastname: Oda
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Honda
mesh_terms: D000818:Animals; D004285:Dogs; D005069:Evaluation Studies as Topic; D008163:Luminescent Measurements; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods; D009569:Nitric Oxide / Q000008:administration & dosage*; D012121:Respiration, Artificial / Q000592:standards*; D012449:Safety
chemical_list: D009569:Nitric Oxide