title: [Clinical studies of reduced accommodation in patients with HIV-1 infection].
abstract: PROBLEM Reduced accommodation in HIV-patients has been described. Yet, in literature, statistics on this item cannot be found. PATIENTS AND METHOD In 58 HIV-infected subjects of different infection stages, accommodation was measured using Clement-Clark's accommodometer. Average age was 34.9 years (sigma = 8.3 years) Stages of HIV-infection were defined according to CDC (Centers for Disease Control)-classification. RESULTS The decrease in accommodation did not show any correlation to the stage of HIV-infection neither to its frequency nor to its amount. An antiretroviral therapy may reduce accommodation loss. However, the effect is not statistically significant. Incommodating accommodation loss occurred only in a few cases. CONCLUSION Reduced accommodation is an early ophthalmological symptom of HIV-1-infection. Possible causes of this phenomenon may be either direct neuronal infection by HIV 1, pathologic changes of the lens or the ciliary body.
authors.affiliation: Universitäts-Augenklinik Würzburg.
authors.forename: S
authors.initials: S
authors.lastname: Thierfelder
authors.forename: G
authors.initials: G
authors.lastname: Mellinghoff-Kreplin
authors.forename: G
authors.initials: G
authors.lastname: Hasenfratz
mesh_terms: D000065:Accommodation, Ocular / Q000187:drug effects / Q000502:physiology*; D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000998:Antiviral Agents
vernacular_title: Klinische Untersuchungen zur Reduktion der Akkommodationsbreite bei Patienten mit HIV-1-Infektion.