[Dual arterial infusion chemotherapy, continuous hyperthermic peritoneal perfusion, and total parietal peritonectomy for peritoneal dissemination in gastric cancer--a case report].
A 36-year-old man developed massive ascites, of which cytology proved Class V, and upper gastrointestinal endoscopy disclosed Borrmann type 4 gastric cancer. We performed dual arterial infusion chemotherapy (DAIC) through the celiac axis and superior mesenteric artery, followed by the operation including continuous hyperthermic peritoneal perfusion, total gastrectomy, subtotal colectomy, massive intestinal resection, splenectomy, cholecystectomy, appendectomy, and total parietal peritonectomy (TPP). Ascites disappeared and the CA125 level was normalized by DAIC. This operation was well tolerated. Though the histopathological study revealed multiple peritoneal disseminations on the visceral peritoneum of stomach, small intestine, colon, and parietal peritoneum such as Douglas' pouch, there were denatured cancer cells in the visceral peritoneum to which blood supply under DAIC was distributed. These results suggested the effect of neoadjuvant DAIC and the significance of TPP.
Fujimura
T
T
Second Dept. of Surgery, School of Medicine, Kanazawa University.
Yonemura
Y
Y
Fujita
H
H
Kawamura
Y
Y
Hasebe
K
K
Kaji
M
M
Nakai
M
M
Ninomiya
I
I
Sahara
H
H
Sugiyama
K
K
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D007263:Infusions, Parenteral; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000556:secondary* / Q000628:therapy*; D010537:Peritoneum / Q000601:surgery*; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy*
D005472:Fluorouracil; D008727:Methotrexate