[An intravenously injectable emulsified iodinated oil contrast agent for liver CT: experimental study of lipiodol emulsion emulsified by lecithin (LEL38) in rabbits].
LEL38 (lipiodol emulsion emulsified by lecithin 38 mgI/ml, mean diameter 200 nm) is a new intravenously injectable oil contrast agent for liver CT. The aim of this report was to evaluate its ability to enhance contrast in the liver of 46 rabbits with regard to the correlation of density with time at an injected dose of 76 mgI/kg (before to 120 minutes after), the correlation of density with dose (0-760 mgI/kg) and the detectability of liver mass. The time-density correlation of LEL38 in the liver, that is, peak density, was achieved after 30 minutes, and it was elevated to 20.9 H. U. Thereafter, it decreased slowly. In the blood vessels, it reached a sharp peak after immediately being elevated to 14. 7 H. U. There after detectability decreased quickly. The maximum difference in density between liver and blood vessels was 34 H. U. after 60 minutes. The dose-density correlation in the liver and blood vessels was linear. Tumors were detected as clear areas of low density. The minimal detectability was about 3 mm. LEL38 may be an effective contrast agent for screening CT studies of liver disease.
Kamei
T
T
Department of Radiology, Kawasaki Medical School.
D000818:Animals; D004655:Emulsions; D005079:Excipients; D005260:Female; D007275:Injections, Intravenous; D007459:Iodized Oil / Q000008:administration & dosage; D008099:Liver / Q000000981:diagnostic imaging*; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging; D010713:Phosphatidylcholines; D011817:Rabbits; D014057:Tomography, X-Ray Computed
D004655:Emulsions; D005079:Excipients; D010713:Phosphatidylcholines; D007459:Iodized Oil