Crocacin, a new electron transport inhibitor from Chondromyces crocatus (myxobacteria). Production, isolation, physico-chemical and biological properties.
Crocacin was isolated from the biomass of the myxobacterium Chondromyces crocatus, strain Cm c3. It inhibited the growth of a few Gram-positive bacteria and a wide spectrum of yeasts and molds. In beef heart submitochondrial particles, crocacin blocked the electron transport within the bc1-segment (complex III) and caused a red shift in the reduced spectrum of cytochrome b with a maximum at 569 nm.
Kunze
B
B
GBF, Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.
Jansen
R
R
Höfle
G
G
Reichenbach
H
H
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004579:Electron Transport / Q000187:drug effects; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009231:Myxococcales / Q000737:chemistry* / Q000378:metabolism*; D011090:Polyenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011090:Polyenes; C089608:crocacin