Effects in vitro of sulfated polysaccharide from Schizymenia dubyi (Rhodophyta, Gigartinales) on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).
An unusual sulfated heteropolysaccharide containing uronic acids, previously isolated from the red alga Schizymenia dubyi, was studied in vitro for its effect on asynchronous cells of a human non-small-cell-bronchopulmonary carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the G1 phase of the cell cycle, and kinetic studies in pretreated cells showed that this growth arrest was irreversible. These events are related to a terminal maturation induction.
Bourgougnon
N
N
ISOMer, Groupe SMAB, Faculté de Pharmacie, Nantes, France.
Roussakis
C
C
Kornprobst
J M
JM
Lahaye
M
M
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001984:Bronchial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000032:analysis; D005453:Fluorescence; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011134:Polysaccharides / Q000494:pharmacology*; D000461:Rhodophyta / Q000737:chemistry; D013431:Sulfates / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D011134:Polysaccharides; D013431:Sulfates