title: Studies on the frequency and associations of equine leucocyte antigens in sarcoid and summer dermatitis.
abstract: The equine leucocyte antigen (ELA) types and the clinical diagnosis for equine sarcoid and summer dermatitis were evaluated in 2026 horses representing five breeds. Data were analysed in unrelated animals and in family material. In the case of equine sarcoid, a strong association was observed between the ELA class II DW13 antigen and its effect on Swiss (cP < 0.001), French (cP < 0.0001) and Irish (cP < 0.01) Warmblood horses. The class I antigen A3 occurred more frequently in sarcoid-affected French horses (cP < 0.001). These results confirm our earlier findings (Gerber et al. 1988). Among Freiberger horses, which lack the ELA DW13 and A3 specificities, a breed-specific class I antigen, ABe108, displayed an increased frequency (cP < 0.05) in the affected group. Among Arabian horses, a tendency for increased frequency of the A1 antigen was observed in the affected animals, but the number of affected horses is too small for statistical significance. The Mendelian segregation in diseased half-siblings by ELA DW13 heterozygous stallions showed a strong association (P < 0.0001) between the inherited DW13 antigen and susceptibility to the sarcoid effect. In the case of summer dermatitis, previously published data (Marti et al. 1992) have been extended. The ELA types in four multiple-case families, founded by the same stallion, were analysed for an association with the effect of sarcoid. Eight out of nine ELA-typed affected offspring inherited the paternal haplotype A15, DW23 in contrast to nonaffected offspring where three out of 12 displayed these antigens (P < 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Immunogenetics, University of Berne, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Lazary
authors.forename: E
authors.initials: E
authors.lastname: Marti
authors.forename: G
authors.initials: G
authors.lastname: Szalai
authors.forename: C
authors.initials: C
authors.lastname: Gaillard
authors.forename: H
authors.initials: H
authors.lastname: Gerber
mesh_terms: D000483:Alleles; D000818:Animals; D052688:Bovine papillomavirus 1; D003872:Dermatitis / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D005260:Female; D005787:Gene Frequency; D006649:Histocompatibility Antigens / Q000235:genetics*; D006734:Horse Diseases / Q000235:genetics* / Q000276:immunology*; D006736:Horses; D007962:Leukocytes / Q000276:immunology; D008297:Male; D030361:Papillomavirus Infections / Q000235:genetics / Q000276:immunology / Q000662:veterinary; D010375:Pedigree; D012507:Sarcoidosis / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D013045:Species Specificity; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology / Q000662:veterinary
chemical_list: D006649:Histocompatibility Antigens