Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy.
Children with spinal muscular atrophy were treated by the administration of thyrotropin-releasing hormone. In three infants with spinal muscular atrophy type I, thyrotropin-releasing hormone showed little efficacy, but in children with types II and III, there was improvement in motor function and electromyographic findings after the thyrotropin-releasing hormone therapy. Thyrotropin-releasing hormone has a neurotrophic effect on the spinal anterior motor neurons of spinal muscular atrophy patients and thus may be warranted for the management of spinal muscular atrophy.
Takeuchi
Y
Y
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Miyanomae
Y
Y
Komatsu
H
H
Oomizono
Y
Y
Nishimura
A
A
Okano
S
S
Nishiki
T
T
Sawada
T
T
D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008475:Median Nerve; D009046:Motor Neurons / Q000187:drug effects; D012720:Severity of Illness Index; D014897:Spinal Muscular Atrophies of Childhood / Q000188:drug therapy*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D013979:Tibial Nerve; D016896:Treatment Outcome
D013973:Thyrotropin-Releasing Hormone