title: Transferable beta lactam resistance against cephalosporins in Salmonella typhimurium strains in India.
abstract: From 14 strains of S. typhimurium which were resistant to three cephalosporins (cephalexin, cefadroxil and sodium cefotaxime) the resistance plasmids were transferred to two different strains (Escherichia coli K12F-Lac-Rifr and S. typhimurium LT2). The plasmids were autotransferable and the donors as well as transconjugants showed high levels of MIC (80-320 micrograms/ml or more) against these antimicrobial agents. The resistance was demonstrated to be mediated by a 15 kilobase plasmid.
authors.affiliation: National Salmonella & Escherichia Centre, Research & Development Division, Central Research Institute, Kasauli.
authors.forename: R
authors.initials: R
authors.lastname: Bhatia
authors.forename: P
authors.initials: P
authors.lastname: Kaur
authors.forename: P C
authors.initials: PC
authors.lastname: John
authors.forename: H
authors.initials: H
authors.lastname: Singh
mesh_terms: D002434:Cefadroxil / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002506:Cephalexin / Q000494:pharmacology; D018550:Cephalosporin Resistance / Q000235:genetics*; D007194:India; D012486:Salmonella typhimurium / Q000187:drug effects*
chemical_list: D002434:Cefadroxil; D002439:Cefotaxime; D002506:Cephalexin