Immunity to a parasite that transforms T lymphocytes.
The past year has seen the first direct evidence that parasite-specific CD8+ T cells can protect cattle against patent infection with Theileria parva. These studies were based on the adoptive transfer between monozygous twins of lymphocytes responding to a challenge with the parasite. Immunization trials are also continuing with a candidate neutralizing vaccine based on the dominant antigen of the T. parva sporozoite surface. This progress has considerably enhanced the prospects for an improved vaccine against the parasite.
McKeever
D J
DJ
International Laboratory for Research in Animal Diseases, Nairobi, Kenya.
Morrison
W I
WI
D000818:Animals; D002417:Cattle; D007109:Immunity; D008213:Lymphocyte Activation; D016052:Protozoan Vaccines / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D016797:Theileria parva / Q000276:immunology*; D013801:Theileriasis / Q000276:immunology*
D016052:Protozoan Vaccines