[Antisense oligonucleotides containing 1-(beta-D-2'-deoxy-threo-pentofuranosyl)thymine at the 3'- and 5'-end].
Oligonucleotides with 3'- and 5'-terminal 1-(beta-D-2'-deoxy-threo-pentafuranosyl)thymin residues (inversion at C3'-atom) were obtained by the automatic phosphoramidite synthesis. The modifications protect oligonucleotides from the nuclease degradation and do not affect the stability of nucleic acid duplexes.
Krynetskaia
N F
NF
Chebotar'
O A
OA
Ibragim
K Kh
KKh
Romanova
E A
EA
Tashlitskiĭ
V N
VN
Oretskaia
T S
TS
Sokolova
N I
NI
Shabarova
Z A
ZA
D001483:Base Sequence; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000737:chemistry* / Q000378:metabolism; D013936:Thymidine / Q000031:analogs & derivatives* / Q000032:analysis
D016376:Oligonucleotides, Antisense; C077504:1-(2'-deoxy-beta-threopentofuranosyl)thymine; D013936:Thymidine
Antisensovye oligonukleotidy, soderzhashchie po 3'- i 5'-kontsam 1-(beta-D'-dezoksi-treo-pentofuranozil)timin.