title: Effect of the butyric short-chain fatty acid on the intracranial pressure and EEG of rabbits.
abstract: In the present study we followed the changes in the intracranial pressure and EEG activity of rabbits caused by the butyric short-chain fatty acid infused as an 0.2 M solution at the rate of 12 ml/h. Changes in the rabbit's normal EEG of paroxysmal nature were initially observed, followed by a rise of intracranial pressure as a result of the edema that developed in the brain. Pretreatment of the animals with an inhibitor of the prostaglandin (PG) synthesis (indomethacin, i.v. 10 mg/kg b.w.) prevented the appearance of paroxysms. The intracranial pressure increased in the presence of indomethacin, but there was a tendency towards reduction of the maximal value reached in the control animals. We conclude that the PG system participates to a varying degree in the genesis of the butyrate-induced changes in the bioelectric cerebral activity and intracranial pressure.
authors.affiliation: Department of Biophysics, University of Medicine, Plovdiv, Bulgaria.
authors.forename: V
authors.initials: V
authors.lastname: Katsarov
authors.forename: I
authors.initials: I
authors.lastname: Kostadinova
authors.forename: A
authors.initials: A
authors.lastname: Kristev
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002087:Butyrates / Q000008:administration & dosage / Q000494:pharmacology*; D020148:Butyric Acid; D004569:Electroencephalography; D007213:Indomethacin / Q000494:pharmacology; D007262:Infusions, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits
chemical_list: D002087:Butyrates; D020148:Butyric Acid; D007213:Indomethacin