[Clinical and experimental studies of jianyi oral liquid in improving learning and memory of the aged].
The effect of Jianyi oral liquid (JYOL) in improving learning and memory of the aged was investigated in this study. The results showed that the learning and memory of the aged subjects and mice was improved after taking JYOL, the level of noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT), cyclic adenosine monophosphate (cAMP) in plasma of aged subjects and brain of aged mice and the content of superoxide dismutase (SOD) in red blood cells of both aged person and mice were significantly higher than those of premedication or control respectively. It was considered that the mechanism of the effect of JYOL in improving learning and memory might related to enhance the brain activity and the capability of clearing free radicals by increasing monoamines, cAMP and SOD of the aged body.
Cai
J G
JG
Suzhou Institute of TCM.
Ren
G R
GR
Jiang
G R
GR
D000368:Aged; D000818:Animals; D001921:Brain / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood
D004365:Drugs, Chinese Herbal; D012701:Serotonin; D000242:Cyclic AMP; D013482:Superoxide Dismutase; D004298:Dopamine; D009638:Norepinephrine