title: Appearance of atopic disease in relation to serum IgE antibodies in children followed up from birth for 4 to 15 years.
abstract: BACKGROUND
  Few studies have addressed the relationship between sensitization and the development of atopic disease over many years.
  
  
  OBJECTIVE
  To study the temporal relationship between the appearance of IgE antibodies in serum and atopic disease, we studied 324 children from three different groups, who were followed up prospectively from birth for 4, 12, and 15 years, respectively.
  
  
  METHODS
  Serum samples were obtained at various ages and analyzed for IgE antibodies against egg white, cow's milk, wheat, animal dander, house dust mite, birch and timothy with Phadebas RAST (Kabi Pharmacia Diagnostics AB, Uppsala, Sweden) or Pharmacia CAP system. In addition, a screening test for atopy, the Phadiatop Paediatric test (Kabi Pharmacia Diagnostics AB) was performed. Presence of atopic disease was assessed by means of clinical examination, interviews, and questionnaires.
  
  
  RESULTS
  In 135 children IgE antibodies were detected at least once to at least one allergen. Antibodies to egg white appeared in 46 children before or at 2 years of age: in 57% of them IgE antibodies to inhalants developed within the next 2 years, and in 19 of 25 (76%) IgE antibodies to inhalants developed before or at 12 to 15 years. Antibodies to inhalant allergens appeared in 55 children during the first 4 years of life and in 64 before 12 to 15 years. Among the former 48% and among the latter 32% had previously detectable egg white antibodies. Atopic disease appeared before or at age 4 years in 80% of the 40 children with IgE antibodies against egg white up to 9 months of age and in 69% of the 58 children who had a positive Phadiatop Paediatric test result in infancy.
  
  
  CONCLUSIONS
  IgE antibodies in children are usually associated with current or later topic disease. Sensitization to foods in infants is usually associated with appearance of IgE antibodies to inhalants later in life.
authors.affiliation: Department of Pediatrics, Borås Hospital, Sweden.
authors.forename: N
authors.initials: N
authors.lastname: Sigurs
authors.forename: G
authors.initials: G
authors.lastname: Hattevig
authors.forename: B
authors.initials: B
authors.lastname: Kjellman
authors.forename: N I
authors.initials: NI
authors.lastname: Kjellman
authors.forename: L
authors.initials: L
authors.lastname: Nilsson
authors.forename: B
authors.initials: B
authors.lastname: Björkstén
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology; D000485:Allergens / Q000276:immunology; D000906:Antibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis*; D007159:Immunologic Tests; D007223:Infant; D007231:Infant, Newborn; D006109:Poaceae; D011058:Pollen / Q000276:immunology; D014197:Trees
chemical_list: D000485:Allergens; D000906:Antibodies; D007073:Immunoglobulin E