title: Expression of desmoglein I in squamous cell carcinoma of the esophagus.
abstract: Desmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined using an anti-DGI monoclonal antibody in 139 patients with squamous cell carcinoma of the esophagus. Normal squamous epithelial cells strongly expressed DGI at their cell-cell boundaries. According to the intensity and pattern of DGI expression, the cancerous tissues were divided into three groups: DGI (++), DGI (+), and DGI (-). Of the 139 tumors, 35 (25%) were DGI (++), 65 (47%) were DGI (+), and 39 (28%) were DGI (-). A good inverse correlation between DGI expression and tumor invasion, lymph node metastasis, lymphatic invasion, and vessel invasion was observed. These results indicate that DGI expression may be a significant factor for invasion, metastasis, and prognosis of human esophageal cancer.
authors.affiliation: First Department of Surgery, Kagoshima University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Natsugoe
authors.forename: T
authors.initials: T
authors.lastname: Aikou
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Kumanohoso
authors.forename: Y
authors.initials: Y
authors.lastname: Tezuka
authors.forename: M
authors.initials: M
authors.lastname: Sagara
authors.forename: H
authors.initials: H
authors.lastname: Yoshinaka
authors.forename: M
authors.initials: M
authors.lastname: Baba
authors.forename: T
authors.initials: T
authors.lastname: Fukumoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000401:mortality / Q000473:pathology* / Q000556:secondary; D003598:Cytoskeletal Proteins / Q000032:analysis*; D051183:Desmoglein 1; D051182:Desmogleins; D051180:Desmoplakins; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016019:Survival Analysis
chemical_list: D003598:Cytoskeletal Proteins; D051183:Desmoglein 1; D051182:Desmogleins; D051180:Desmoplakins