title: An analysis of the effect of venous resistance on the performance of gravity-fed intravenous infusion systems.
abstract: OBJECTIVE
  Our objective was to assess the effect of venous resistance in a clinically relevant range on flow rates through intravenous (i.v.) cannulae.
  
  
  METHODS
  Since resistances in series are additive, the sum of the resistance of the i.v. cannula and the vein equates to the total resistance to flow. Using resistance data from earlier work, the total resistance for various combinations of cannula and vein size was calculated, allowing a prediction to be made of the comparative flow rates between these combinations for a given driving pressure. Next, the clinical situation was simulated by measuring flow rates through i.v. cannulae connected in series to a variety of infusion devices with resistances known to be within the range of clinically relevant venous resistance.
  
  
  RESULTS
  The effect of venous resistance was greatest on large-bore cannulae, with significant reductions in flow occurring when even low levels of venous resistance were added. Throughout much of the range of venous resistances encountered clinically, total flows through two small-gauge cannulae exceeded that through a single large-gauge cannula.
  
  
  CONCLUSIONS
  To achieve maximum benefit from a large-bore cannula, a suitably large vein must be chosen. Further, where venous access is difficult and high flow potential from an infusion system is required, two separate infusions through small cannulae may be a preferable option to a single large bore.
authors.affiliation: Department of Anesthesia, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: D B
authors.initials: DB
authors.lastname: Goodie
authors.forename: J H
authors.initials: JH
authors.lastname: Philip
mesh_terms: D005542:Forearm / Q000098:blood supply; D006225:Hand / Q000098:blood supply; D006801:Humans; D007262:Infusions, Intravenous / Q000295:instrumentation; D008954:Models, Biological; D008961:Models, Structural; D008962:Models, Theoretical; D012212:Rheology; D014655:Vascular Resistance; D014680:Veins / Q000502:physiology*