Acquired factor VIII inhibitor associated with chronic interferon-alpha therapy in a patient with haemophilia A.
Both the development of factor VIII inhibitors and infection by hepatitis C virus are serious complications of haemophilia A. We describe the first reported case of the subsequent development of a factor VIII inhibitor in a patient with haemophilia A after treatment with interferon-alpha for chronic active hepatitis C.
Castenskiold
E C
EC
Department of Haematology, Royal London Hospital, Whitechapel.
Colvin
B T
BT
Kelsey
S M
SM
D000328:Adult; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006467:Hemophilia A / Q000097:blood* / Q000150:complications; D006526:Hepatitis C / Q000150:complications / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000150:complications / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
D016898:Interferon-alpha; D005169:Factor VIII