Role of glutathione in cyclosporine A in vitro hepatotoxicity.
Wolf
A
A
Sandoz Pharma Ltd., Drug Safety Department, Basle, Switzerland.
Trendelenburg
C F
CF
Diez-Fernandez
C
C
Prieto
P
P
Cordier
A
A
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D019328:Buthionine Sulfoximine; D002478:Cells, Cultured; D016572:Cyclosporine / Q000633:toxicity*; D004229:Dithiothreitol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism*; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D000963:Antimetabolites; D017392:Thiobarbituric Acid Reactive Substances; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D016572:Cyclosporine; D007770:L-Lactate Dehydrogenase; D005978:Glutathione; D004229:Dithiothreitol