title: Characterization of epidemic Neisseria meningitidis serogroup C strains in several Brazilian states.
abstract: Epidemic strains of the Neisseria meningitidis C:2b:P1.3 electrophoretic type 11 complex were responsible for an outbreak in Curitiba, Parana State, Brazil, from 1990 to 1991. Strains of this complex were also isolated in other Brazilian states and were responsible for a meningococcal disease epidemic in São Paulo State in 1990. Serotyping both with monoclonal antibodies and by multilocus enzyme electrophoresis was useful for typing these epidemic strains related to the increased incidence of meningococcal disease. The genetic similarity of members of the electrophoretic type 11 complex was confirmed by the ribotyping method by using EcoRI or ClaI endonuclease restriction enzymes.
authors.affiliation: Bacteriology Division, Adolfo Lutz Institute, São Paulo, Brazil.
authors.forename: C T
authors.initials: CT
authors.lastname: Sacchi
authors.forename: M L
authors.initials: ML
authors.lastname: Tondella
authors.forename: A P
authors.initials: AP
authors.lastname: de Lemos
authors.forename: M C
authors.initials: MC
authors.lastname: Gorla
authors.forename: D B
authors.initials: DB
authors.lastname: Berto
authors.forename: N H
authors.initials: NH
authors.lastname: Kumiochi
authors.forename: C E
authors.initials: CE
authors.lastname: Melles
mesh_terms: D015373:Bacterial Typing Techniques; D001938:Brazil / Q000453:epidemiology; D004275:DNA, Ribosomal / Q000032:analysis; D004196:Disease Outbreaks; D006801:Humans; D008589:Meningococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics
chemical_list: D004275:DNA, Ribosomal