title: Expression of the FGFR1 gene in human breast-carcinoma cells.
abstract: Fibroblast growth factors (FGF) constitute a family of at least 9 members which act through high-affinity tyrosine-kinase receptors encoded by 4 distinct genes. In humans, the FGFR1 gene is located in chromosomal region 8p12. Its amplification and expression were examined in a panel of 110 breast carcinoma samples by Southern- and Northern-blot analyses. FGFR1 was amplified in 9% and overexpressed in about 15% of the tumors studied. In situ hybridization experiments were performed on tissue sections of normal breast and tumors with a high level of FGFR1 expression. In both normal and tumoral tissues, FGFR1 RNA was detected in the epithelial cells. Overexpression of FGFR1 seems to be associated with small, well-differentiated diploid tumors.
authors.affiliation: Département d'Anatomo-Pathologie, Institut Paoli-Calmettes, Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Jacquemier
authors.forename: J
authors.initials: J
authors.lastname: Adelaide
authors.forename: P
authors.initials: P
authors.lastname: Parc
authors.forename: F
authors.initials: F
authors.lastname: Penault-Llorca
authors.forename: J
authors.initials: J
authors.lastname: Planche
authors.forename: O
authors.initials: O
authors.lastname: deLapeyriere
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
mesh_terms: D015152:Blotting, Northern; D015139:Blotting, Southern; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005346:Fibroblast Growth Factors / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D012334:RNA, Neoplasm / Q000096:biosynthesis; D020794:Receptor Protein-Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1; D017468:Receptors, Fibroblast Growth Factor / Q000096:biosynthesis* / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D012334:RNA, Neoplasm; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; C496348:FGFR1 protein, human; D020794:Receptor Protein-Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1