title: Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives.
abstract: The synthesis of 4-adamantyl-5-aryl-3-phenyl-delta 2-1,2,4-oxadiazolines, involving an 1,3-dipolar cycloaddition reaction between 1-[(arylidene)amino]adamantanes and benzonitriloxide, is described. The evaluation of in vitro antiviral activity against human immunodeficiency virus (HIV) of the compounds obtained is also reported.
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Chimirri
authors.forename: S
authors.initials: S
authors.lastname: Grasso
authors.forename: A M
authors.initials: AM
authors.lastname: Monforte
authors.forename: P
authors.initials: P
authors.lastname: Monforte
authors.forename: M
authors.initials: M
authors.lastname: Zappalà
authors.forename: A
authors.initials: A
authors.lastname: Carotti
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans; D010069:Oxadiazoles / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D010069:Oxadiazoles