Breastmilk can mediate chemical imprinting. Benzpyrene exposure during lactation reduces the thymic glucocorticoid receptor density of the offspring.
1. Prolonged benzpyrene treatment during lactation reduced the number of glucocorticoid receptors of offspring in adulthood significantly without altering the receptor affinity. 2. Dexamethasone treatment identical to benzpyrene exposure had no effect either on receptor number or affinity. 3. The results of the present investigations draw attention to the possible way of receptor alteration via breastmilk.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Inczefi-Gonda
A
A
D000818:Animals; D000833:Animals, Suckling; D001564:Benzo(a)pyrene / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004785:Environmental Pollutants / Q000494:pharmacology*; D005260:Female; D007774:Lactation / Q000187:drug effects*; D008892:Milk / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000187:drug effects*; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism
D004785:Environmental Pollutants; D011965:Receptors, Glucocorticoid; D001564:Benzo(a)pyrene; D003907:Dexamethasone