title: [Genetic characteristics of scirrhous gastric carcinomas].
abstract: Genetic characteristics of scirrhous gastric carcinomas are overviewed. Scirrhous carcinomas of the stomach frequently show amplification of c-met and K-sam oncogenes as well as overexpression of 6.0 kb c-met abnormal transcript. For the formation of productive fibrosis and the diffuse infiltrative growth pattern of this malignancy, the essential factors would be not only the loss of cell adhesion molecule function through depressed expression or loss of cadherin or catenin, but also the synchronous overexpression of growth factors from the cancer cells including TGF-beta, PDGF, IGF-II and basic FGF with intimate cancer-stromal interaction through paracrine loop of IL-1 alpha/HGF system.
authors.affiliation: Dept. of Pathology, Hiroshima University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yokozaki
authors.forename: H
authors.initials: H
authors.lastname: Kuniyasu
authors.forename: W
authors.initials: W
authors.lastname: Yasui
authors.forename: E
authors.initials: E
authors.lastname: Tahara
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D002293:Adenocarcinoma, Scirrhous / Q000235:genetics* / Q000473:pathology; D005346:Fibroblast Growth Factors / Q000235:genetics*; D005784:Gene Amplification; D015870:Gene Expression; D016158:Genes, p53; D017228:Hepatocyte Growth Factor / Q000235:genetics*; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D009154:Mutation; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D017228:Hepatocyte Growth Factor; D007335:Insulin-Like Growth Factor II