Species differences in cAMP production and contractile response induced by beta-adrenoceptor subtypes in urinary bladder smooth muscle.
The contractile activity of urinary bladder smooth muscle has been shown to be inhibited by beta-adrenoceptor agonists. beta-Adrenoceptor subtypes in the rabbit, canine, and human urinary bladder smooth muscles were studied by measuring changes in contractile forces and in intracellular cAMP concentrations on administration of beta-adrenoceptor agonists. In the rabbit bladder, only beta 2-receptors may have functional roles in the detrusor muscle, while both beta 1- and beta 2-receptors may have functional roles in the detrusor muscles of the canine bladder. Only beta 2-receptors may have functional roles in the human detrusor muscles, similar to the rabbit detrusor muscles. Thus, species differences may exist in beta-adrenoceptor subtypes in smooth muscles of urinary bladder.
Morita
T
T
Department of Urology, Tokyo Medical and Dental University School of Medicine, Japan.
Ando
M
M
Kihara
K
K
Oshima
H
H
D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis*; D004280:Dobutamine / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity; D013726:Terbutaline / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D004280:Dobutamine; D000242:Cyclic AMP; D007545:Isoproterenol; D013726:Terbutaline