title: Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease.
authors.affiliation: Neurology Service, Massachusetts General Hospital, Boston 02114.
authors.forename: B T
authors.initials: BT
authors.lastname: Hyman
authors.forename: T
authors.initials: T
authors.lastname: Gomez-Isla
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002452:Cell Count; D002540:Cerebral Cortex / Q000473:pathology; D006801:Humans; D009474:Neurons / Q000502:physiology