Synthesis and anticonvulsant activity of some new 3-(p-sulfamoylphenyl)-4(3H)-quinazolinones.
In view of their expected anticonvulsant property, a series of 3-(p-sulfamoylphenyl)-4(3H)-quinazolinone derivatives (V) were synthesized by condensation of sulfanilamide with various 4H-3,1-benzoxazin-4-ones (III). Some 2-amido-N-(p-sulfamoylphenyl)benzamides (IV) were isolated as reaction intermediates. The structures of V were confirmed by IR, 1H-NMR, MS and elemental analyses. Some of the compounds V showed significant anticonvulsant effects against pentetrazol-induced convulsions.
el-Naser Ossman
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AR
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt.
el-Sayed Barakat
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S
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001001:Anura; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010634:Phenobarbital / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000927:Anticonvulsants; D011799:Quinazolines; D010433:Pentylenetetrazole; D010634:Phenobarbital