title: [The effect of radiation on malignant cells].
abstract: Mechanisms of death following irradiation of malignant cells are incompletely understood. Radiation-induced lesions and their consequences on the cancer cell are described. Factors conditioning malignant cell response to radiation are discussed, as well as the mechanisms of radiation-induced carcinogenesis. Finally, the recent molecular biology contributions to gene regulation during cell growth are presented.
authors.affiliation: Département de radiothérapie, Centre Léon-Bérard, Lyon.
authors.forename: F
authors.initials: F
authors.lastname: Mornex
authors.forename: V
authors.initials: V
authors.lastname: Favaudon
authors.forename: J J
authors.initials: JJ
authors.lastname: Mazeron
mesh_terms: D002453:Cell Cycle / Q000528:radiation effects; D016923:Cell Death; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D002477:Cells / Q000528:radiation effects*; D004247:DNA / Q000528:radiation effects; D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011836:Radiation Tolerance
chemical_list: D004247:DNA
vernacular_title: Action des radiations sur les cellules malignes.