[Effects of 1,5 benzodiazepine beta lactam on sleep].
Various substances have been used as sleep inductors, but their use has declined, due to their undesirable side effects, and they have been replaced mainly by benzodiazepines. There currently exists a great variety of benzodiazepines with an increasing, clinical use, although they also present certain disadvantages. The effect on sleep of the intraperitoneal administration (0.9 mg/kg) of 7-(p-cl-phenyl)-8-phenoxy-4,5-benzo-3-aza-2-none, was analysed in chronically implanted wistar rats. Results indicate that this substance decreases wakefulness and increases significantly slow-wave and paradoxical sleep. Latency of the first phase of paradoxical sleep show a tendency to increase. It is concluded that this substance has hypnogenic effects.
Ayala-Guerrero
F
F
Instituto de Investigaciones Biomédicas e Instituto de Química, UNAM, Ciudad Universitaria, México, D. F.
Vargas-Reyna
L
L
Taboada
J
J
Martinez
R
R
Cortes
E
E
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines
Efecto de una beta lactama de 1.5 benzodiazepina sobre el sueño.