Nutritional therapy for progressive renal failure.
Results of the Diabetes Control and Complications Trial indicate that intensive insulin treatment of patients with type I diabetes would greatly reduce the incidence of diabetic nephropathy. Another multicenter trial indicates that modest protein restriction is of no value in children with chronic renal failure. The relationship between urea nitrogen excretion and total nitrogen excretion in children differs from that in adults. A repeated crossover study found that ketoacids slow progression of renal failure, in comparison with amino acid supplements to the same diet. Long-term protein restriction does not lead to protein deficiency at the onset of dialysis. When combined with essential amino acid supplements, a low-protein diet may gradually correct hypoalbuminemia in nephrotic subjects.
Walser
M
M
Johns Hopkins University School of Medicine, Baltimore, Maryland.
D000596:Amino Acids / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007651:Keto Acids / Q000008:administration & dosage; D007676:Kidney Failure, Chronic / Q000178:diet therapy* / Q000517:prevention & control; D015337:Multicenter Studies as Topic; D009404:Nephrotic Syndrome / Q000178:diet therapy; D009747:Nutritional Physiological Phenomena; D010349:Patient Compliance
D000596:Amino Acids; D004044:Dietary Proteins; D007651:Keto Acids