Relationship between diabetic autonomic neuropathy and peripheral neuropathy as assessed by power spectral analysis of heart rate variations and vibratory perception thresholds.
To investigate the relationship between diabetic autonomic and peripheral neuropathies, we carried out power spectral analysis (PSA) of heart rate variations and determined the vibratory perception threshold (VPT) in diabetic subjects (DM). The VPT, measured with a Suzuki-Matsuoka Vibrometer (SMV-5), was greater in diabetic subjects than in controls. The low frequency (LF) component of the PSA which represents sympathetic nervous activity and the high frequency (HF) component of the PSA which indicates parasympathetic nervous activity were significantly decreased in diabetic subjects when compared to values in the controls. In addition, there were significant inverse correlations between the LF and HF components of the PSA of heart rate variations and the VPT. These results suggest that the PSA of heart rate variations and the measurement of VPT are useful tools for evaluating diabetic autonomic and peripheral neuropathies.
Yoshioka
K
K
First Department of Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.
Terasaki
J
J
D001341:Autonomic Nervous System / Q000502:physiology / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D011187:Posture; D012016:Reference Values; D012044:Regression Analysis; D012684:Sensory Thresholds; D012890:Sleep; D016683:Supine Position