title: Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine.
abstract: The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, s.c.) and centrally administered anisomycin (300 micrograms/10 microliters, i.c.v.) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, s.c.) completely blocked lithium-pilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
authors.affiliation: Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham 35294.
authors.forename: M B
authors.initials: MB
authors.lastname: Williams
authors.forename: R S
authors.initials: RS
authors.lastname: Jope
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000008:administration & dosage / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D003513:Cycloheximide / Q000008:administration & dosage / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D018021:Lithium Chloride / Q000633:toxicity*; D008297:Male; D010862:Pilocarpine / Q000633:toxicity*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D013226:Status Epilepticus / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D013997:Time Factors
chemical_list: D011500:Protein Synthesis Inhibitors; D010862:Pilocarpine; D000841:Anisomycin; D003513:Cycloheximide; D018021:Lithium Chloride