title: Mapping of the human gene for inducible heme oxygenase to chromosome 22q12.
abstract: Heme oxygenase is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, releasing carbon monoxide and iron. There are two isozymes of heme oxygenase: heme oxygenase 1 (HO-1) and heme oxygenase 2, each of which is encoded by a separate gene. It is noteworthy that HO-1 is inducible by various environmental factors, while heme oxygenase 2 is not. Here we have localized the human HO-1 gene to chromosome 22 by polymerase chain reaction (PCR) analysis of human-hamster somatic cell hybrids. The precise region of the HO-1 locus was then determined by fluorescence in situ hybridization, revealing that the human HO-1 gene is localized to 22q12.
authors.affiliation: Department of Hygiene, Ehime University School of Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Kuwano
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Nakai
authors.forename: I
authors.initials: I
authors.lastname: Kondo
authors.forename: S
authors.initials: S
authors.lastname: Shibahara
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006224:Cricetinae; D004790:Enzyme Induction; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D016133:Polymerase Chain Reaction
chemical_list: D006419:Heme Oxygenase (Decyclizing)