[Application of immunosuppressants for therapy of patients with vasculitis].
Immunosuppressants are applied clinically on vasculitis. Cyclophosphamide, azathioprine, and methotrexate are used most often. Other immunosuppressants, such as bredinin, FK506, monoclonal antibody, and adhesion molecule are studied in laboratory level or in small group clinical trial. In combination therapy, immunosuppressants are used with corticosteroids, which are the first choice drug on angitis. Methotrexate is administered as intermittent manner. Since immunosuppressants have side effects including oncogenicity and immunotoxicity, clinicians have to pay much attention on clinical course of the patients with vasculitis.
Abe
C
C
St. Marrianna University School of Medicine, Institute of Medical Science.
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D013256:Steroids; D014657:Vasculitis / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D013256:Steroids