title: Continuous vs discontinuous enteral nutrition: compared effects on serum lipids and lipoproteins in humans.
abstract: The present study was designed to assess the cholesterol-lowering effect of enteral nutrition when administered either as discontinuous or as continuous infusion. Twelve neurologic patients were randomly assigned to receive exclusive continuous (n = 6) or discontinuous (n = 6) enteral feeding for 7 days. Serum lipids, apoproteins, and 24-hour urinary C-peptide concentrations were determined on days 0 and 7. The fall during continuous nutrition was significantly greater than that during discontinuous nutrition for serum cholesterol (14% vs 2.4%; p < .05), low-density lipoprotein cholesterol (17.4% vs 3.9%; p = .02), and apoprotein B (19% vs 0.2%; p < .05) concentrations. Mean 24-hour urinary C-peptide excretion increase was significantly greater (p < .05) during discontinuous (78%) than during continuous enteral nutrition (15.6%). These results suggest that the cholesterol-lowering effect of enteral nutrition was induced mainly by the continuous delivery of the nutrients and was related to changes in insulin secretion.
authors.affiliation: Gastroenterology and Nutritional Support Unit, University Hospital, Poitiers, France.
authors.forename: P
authors.initials: P
authors.lastname: Beau
authors.forename: J
authors.initials: J
authors.lastname: Labat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000097:blood; D002096:C-Peptide / Q000652:urine; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009422:Nervous System Diseases / Q000628:therapy; D013997:Time Factors
chemical_list: D001055:Apolipoproteins B; D002096:C-Peptide; D008078:Cholesterol, LDL; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins; D005934:Glucagon; D002784:Cholesterol