L-741,494, a fungal metabolite that is an inhibitor of interleukin-1 beta converting enzyme.
gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin. It has a mol wt of 154 and an empirical formula of C7H6O4. We propose the name xylaric acid for this compound.
Salvatore
M J
MJ
Merck Research Laboratories, Rahway, New Jersey 07065.
Hensens
O D
OD
Zink
D L
DL
Liesch
J
J
Dufresne
C
C
Ondeyka
J G
JG
Jürgens
T M
TM
Borris
R P
RP
Raghoobar
S
S
McCauley
E
E
D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000595:Amino Acid Sequence; D020170:Caspase 1; D002852:Chromatography, Ion Exchange; D003546:Cysteine Endopeptidases / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008666:Metalloendopeptidases / Q000737:chemistry*; D008969:Molecular Sequence Data; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013098:Xylariales / Q000378:metabolism*
D000085:Acetates; C089560:L 741494; D011753:Pyrones; D003546:Cysteine Endopeptidases; D020170:Caspase 1; D008666:Metalloendopeptidases