Roles of growth hormone and growth factors in the pathogenesis and treatment of kidney disease.
Growth hormone and a number of polypeptide growth factors exert actions on renal development, growth, and metabolism and on repair processes following renal injury. There is increasing evidence that under selected circumstances, these agents play roles in the pathogenesis of kidney disease and that under others, they may be useful in its treatment. Growth hormone, platelet-derived growth factor, or transforming growth factor-beta may be causative of glomerulosclerosis. The reduction in epidermal growth factor expression within the kidney in the setting of acute ischemic injury could delay regeneration, and replacement may be therapeutic. Insulin-like growth factor I may play a role in the regenerative response to acute renal injury. Pharmacologic properties of growth hormone or insulin-like growth factor I to enhance glomerular filtration rate and renal plasma flow and to increase skeletal growth may be harnessable for treating chronic renal failure and its complications. It is likely that strategies designed to employ growth hormone or growth factors as pharmacologic agents or to block their activities will assume increasingly important roles in therapy for renal disease.
O'Shea
M
M
Washington University School of Medicine, St. Louis, Missouri.
Miller
S B
SB
Finkel
K
K
Hammerman
M R
MR
D000818:Animals; D013006:Growth Hormone / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology* / Q000628:therapy
D006133:Growth Substances; D013006:Growth Hormone