[Changes of cellular hydroxyl proline and some other parameters of rats in early bronchoalveolar lavage treated with quartz dust].
The changes of cellular hydroxyl proline (Hyp) and some other parameters in bronchoalveolar lavage (BAL) induced by different doses of quartz dust (5, 10, 20, or 40mg/per rat) were studied. Quartz dust was administered intratracheally and the rats were killed two weeks after quartz administration. The results showed that the differential count of polymorphonuclear leukocytes (PMN) in BAL, the concentrations of Hyp and total lipids in BAL cells, and the levels of total lipids, total protein, lactic dehydrogenase (LDH) and ceruloplasmin in BAL supernatant all changed significantly in quartz treated groups compared with the control group. Further investigation revealed that the cellular Hyp correlated best with total lung collagen (r = 0.834). This indicated that Hyp might be a specific and important parameter reflecting early increase of total lung collagen after quartz dust administration.
Qin
X F
XF
Department of Occupational Health, Beijing Medical University.
Liu
S J
SJ
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000166:cytology; D004391:Dust; D006909:Hydroxyproline / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D011791:Quartz; D051381:Rats; D017208:Rats, Wistar; D012829:Silicosis / Q000378:metabolism
D004391:Dust; D011791:Quartz; D007770:L-Lactate Dehydrogenase; D006909:Hydroxyproline