Effect of immobilization stress on tumor growth in mice.
The effect of immobilization stress applied daily for 2 h on the development of MF-RSV tumor graft in mice and on survival of the hosts was studied. While a single acute stress applied to mice simultaneously with a transfer of MF-RSV cells stimulated antitumor defense, chronic stress applied both before and/or after tumor cell implantation accelerated the death of recipients. The shortest survival time was found in mice which were stressed for 3 weeks before implantation and on, until their death. Heat shock applied to MF-RSV tumor cells before implantation significantly reduced their growth ability in the hosts.
Mazur-Kolecka
B
B
Department of Immunology, Polish Academy of Sciences, Kraków.
Machala
O
O
Skowron-Cendrzak
A
A
Kubera
M
M
Bubak-Satora
M
M
Basta-Kaim
A
A
Roman
A
A
D000818:Animals; D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D006358:Hot Temperature; D007103:Immobilization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*; D012769:Shock / Q000503:physiopathology; D013312:Stress, Physiological / Q000209:etiology / Q000503:physiopathology*; D014407:Tumor Cells, Cultured