title: Cytogenetics as a tool in the histologic subclassification of chondrosarcomas.
abstract: Chondrosarcomas are a heterogeneous group of bone neoplasms of which the basic neoplastic tissue is cartilaginous. Frequently the histologic diagnosis and grading of chondrosarcomas is difficult and the histologic appearance does not always reflect the biologic behavior of these tumors. Therefore, it is important to find other parameters that can be of help in the proper diagnosing and grading of these neoplasms. To this end, we attempted to correlate the chromosomal pattern of chondrosarcomas to their histologic subtypes and grades. The cytogenetic analysis of two intermediate-grade chondrosarcomas of bone, and a review of the literature, are presented.
authors.affiliation: Department of Medical Genetics, University of Groningen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Dijkhuizen
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
authors.forename: W M
authors.initials: WM
authors.lastname: Molenaar
authors.forename: J W
authors.initials: JW
authors.lastname: Oosterhuis
authors.forename: A
authors.initials: A
authors.lastname: Dam
authors.forename: J
authors.initials: J
authors.lastname: Wiersema
authors.forename: H
authors.initials: H
authors.lastname: Schraffordt Koops
authors.forename: B
authors.initials: B
authors.lastname: de Jong
mesh_terms: D001859:Bone Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D002813:Chondrosarcoma / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged