title: Determinants of low systemic vascular resistance during cardiopulmonary bypass.
abstract: Although low systemic vascular resistance occurs during normothermic and hypothermic cardiopulmonary bypass, the determinants of depressed systemic vascular resistance and its effect on outcomes are unknown. To assess the predictors and clinical effects of low systemic vascular resistance, 555 patients undergoing isolated coronary artery bypass grafting were evaluated prospectively. The extent of low systemic vascular resistance during bypass was estimated by the amount of the vasoconstrictor phenylephrine administered: group 1, 0 to 160 micrograms; group 2, 161 to 800 micrograms; group 3, more than 800 micrograms. Multivariate analysis identified bypass temperature, bypass time, and ventricular function as determinants of low systemic vascular resistance. Patients on normothermic bypass accounted for 65% of the patients in group 3 and only 34% of the patients in group 1 (p < 0.0001). The bypass time was longer in the patients in group 3 (97 +/- 28 minutes) than in the patients in group 1 (89 +/- 24 minutes; p < 0.006). Patients with a preoperative left ventricular ejection fraction of 0.40 or less required less phenylephrine during cardiopulmonary bypass (498 +/- 68 micrograms) than did patients with a fraction exceeding 0.40 (1,087 +/- 88 micrograms; p < 0.001). By multivariate analysis, advanced age and the presence of peripheral vascular disease were found to decrease the likelihood of low systemic vascular resistance during normothermic bypass. Diabetes, the left ventricular ejection fraction, the bypass time, and the total cardioplegia infused were found to influence the likelihood of low systemic vascular resistance during hypothermic bypass. Patients in group 3 had a higher cardiac index and lower-mean arterial pressure and systemic vascular resistance postoperatively. In those patients who received a left internal mammary artery graft, the incidences of the low-output syndrome (group 1, 4.9%; group 3, 2.7%; p = not significant) and myocardial infarction (group 1, 1.4%; group 3, 1.8%; p = not significant) were not influenced by the amount of phenylephrine infused during cardiopulmonary bypass. In those patients who were at high risk of suffering a stroke preoperatively, the hypotension induced by the low systemic vascular resistance and its treatment with phenylephrine was not associated with an increased incidence of stroke (group 1, 5.8%; group 3, 2.8%; p = not significant).
authors.affiliation: Division of Cardiovascular Surgery and Clinical Epidemiology Unit, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
authors.forename: G T
authors.initials: GT
authors.lastname: Christakis
authors.forename: S E
authors.initials: SE
authors.lastname: Fremes
authors.forename: J P
authors.initials: JP
authors.lastname: Koch
authors.forename: S
authors.initials: S
authors.lastname: Harwood
authors.forename: S
authors.initials: S
authors.lastname: Juhasz
authors.forename: E
authors.initials: E
authors.lastname: Sharpe
authors.forename: K A
authors.initials: KA
authors.lastname: Deemar
authors.forename: C
authors.initials: C
authors.lastname: Hamilton
authors.forename: E
authors.initials: E
authors.lastname: Chen
authors.forename: V
authors.initials: V
authors.lastname: Rao
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature; D002314:Cardioplegic Solutions; D001026:Coronary Artery Bypass; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D015999:Multivariate Analysis; D016491:Peripheral Vascular Diseases / Q000503:physiopathology; D010656:Phenylephrine / Q000494:pharmacology; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors; D014655:Vascular Resistance; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology
chemical_list: D002314:Cardioplegic Solutions; D010656:Phenylephrine