title: Acquired factor VIII inhibitor associated with chronic interferon-alpha therapy in a patient with haemophilia A.
abstract: Both the development of factor VIII inhibitors and infection by hepatitis C virus are serious complications of haemophilia A. We describe the first reported case of the subsequent development of a factor VIII inhibitor in a patient with haemophilia A after treatment with interferon-alpha for chronic active hepatitis C.
authors.affiliation: Department of Haematology, Royal London Hospital, Whitechapel.
authors.forename: E C
authors.initials: EC
authors.lastname: Castenskiold
authors.forename: B T
authors.initials: BT
authors.lastname: Colvin
authors.forename: S M
authors.initials: SM
authors.lastname: Kelsey
mesh_terms: D000328:Adult; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006467:Hemophilia A / Q000097:blood* / Q000150:complications; D006526:Hepatitis C / Q000150:complications / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000150:complications / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
chemical_list: D016898:Interferon-alpha; D005169:Factor VIII