title: Human biodistribution, dosimetry and clinical use of technetium(III)-99m-Q12.
abstract: Technetium(III)-99m-Q12, trans-(1,2-bis(dihydro-2,2,5,5-tetramethyl- 3(2H)furanone-4-methyleneimino)ethane)bis(tris(3-methoxy-1-propyl) - phosphine)technetium(III)-99m, is a nonreducible complex of Tc(III) which is herein evaluated as a myocardial perfusion imaging agent.
  
  
  METHODS
  The biodistribution and dosimetry of 99mTc-Q12 were assessed in 10 normal volunteers, while its potential clinical use was evaluated in 70 patients.
  
  
  RESULTS
  Safety parameters measured up to 24 hr postinjection demonstrate no clinically significant drug-related adverse reactions. Technetium(III)-99m-Q12 exhibits good heart uptake (2.2% injected dose at 1 hr postinjection under resting conditions) and no detectable myocardial washout or redistribution up to 5 hr postinjection. The biodistribution is characterized by very rapid hepatobiliary clearance which allows effective myocardial imaging at times as short as 15 min postinjection. Blood and plasma clearances and myocardial uptake are rapid, while lung uptake is minimal. The heart-to-lung and heart-to-liver ratios are higher at stress than at rest, independent of the time elapsed between injection and image acquisition, and independent of whether the patient is fasted or fed after tracer administration. A preliminary correlation shows that 46/47 patients with angiographically demonstrated CAD also have perfusion defects demonstrated by 99mTc-Q12.
  
  
  CONCLUSIONS
  On the basis of the studies reported herein, 99mTc-Q12 appears to be a promising myocardial perfusion imaging agent.
authors.affiliation: Institute H.S. Raffaele, Milano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Rossetti
authors.forename: G
authors.initials: G
authors.lastname: Vanoli
authors.forename: G
authors.initials: G
authors.lastname: Paganelli
authors.forename: M
authors.initials: M
authors.lastname: Kwiatkowski
authors.forename: F
authors.initials: F
authors.lastname: Zito
authors.forename: F
authors.initials: F
authors.lastname: Colombo
authors.forename: C
authors.initials: C
authors.lastname: Bonino
authors.forename: A
authors.initials: A
authors.lastname: Carpinelli
authors.forename: R
authors.initials: R
authors.lastname: Casati
authors.forename: K
authors.initials: K
authors.lastname: Deutsch
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005215:Fasting; D005260:Female; D005663:Furans / Q000493:pharmacokinetics; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D005663:Furans; D015609:Organotechnetium Compounds; C078496:technetium Tc 99m Q12