title: [Differences in hemodynamic effects of the cardioselective beta-adrenoblocker acebutolol and non-selective beta-adrenoblocker propranolol in long-term antihypertensive therapy].
abstract: The cardioselective beta-adrenoblocker acebutolol used as a course therapy for 12 weeks was found to be a highly beneficial antihypertensive agent. The antihypertensive effect of the agent given in doses of 400-800 mg/day was as pronounced and prolonged as that of propranolol, 80-160 mg/day, though there is a tendency for acebutolol to show its complete or partial antihypertensive effect rather at the end of monotherapy than propranolol. At the same time the bradycardiac effect was more pronounced in propranolol therapy. The antihypertensive effect of acebutolol, 400-800 mg/day, was revealed after 2 weeks of its use and persisted within the entire 12 weeks of therapy. The drug was well tolerated. In contrast to propranolol, a non-selective beta-adrenoblocker having no intrinsic sympathomimetic activity, acebutolol failed to produce adverse effects, such as by decreasing cardiac output and increasing total peripheral vascular resistance. The agent had a less negative chronotropic effect.
authors.forename: V I
authors.initials: VI
authors.lastname: Metelitsa
authors.forename: S G
authors.initials: SG
authors.lastname: Duda
authors.forename: T P
authors.initials: TP
authors.lastname: Ostrovskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Malysheva
authors.forename: O V
authors.initials: OV
authors.lastname: Lerman
authors.forename: R S
authors.initials: RS
authors.lastname: Shastun
authors.forename: E M
authors.initials: EM
authors.lastname: Manoshkina
authors.forename: V K
authors.initials: VK
authors.lastname: Piotrovskiĭ
authors.forename: D O
authors.initials: DO
authors.lastname: Rumiantsev
authors.forename: V G
authors.initials: VG
authors.lastname: Belolipetskaia
mesh_terms: D000070:Acebutolol / Q000494:pharmacology* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000070:Acebutolol; D011433:Propranolol
vernacular_title: Osnovnye razlichiia gemodinamicheskikh éffectov kardioselektivnogo beta-adrenoblokatora atsebutolola i neselektivnogo beta-adrenoblokatora propranolola pri dlitelńoĭ antigipertenzivnoĭ terapii.