An immunohistological study of post-transfusion graft-versus-host disease (GVHD).
We reported clinicopathological, histopathological and immunohistological features of two suggestive cases with post transfusion graft-versus-host disease (GVHD) and examined. In addition, we have declared histopathologic characteristics of acute and chronic GVHD with literatural consideration. On the basis of a review of two cases, we came to the following conclusion; It is implied that early lymphoid proliferation may be useful to make a diagnosis of acute GVHD. Case 2 had pathological confirmation of acute GVHD in the liver and small intestine. In the liver, a damage of interlobular bile ducts and T lymphocytes infiltration close to ducts were the most specific feature of acute GVHD. From an immunohistological study in case 2, it was confirmed that abnormal expression of HLA-DR antigen and the appearance of activated T lymphocytes played an important role in the development of GVHD reaction in the liver.
Hojo
H
H
Department of Pathology I, Fukushima Medical College, Japan.
Kainuma
Y
Y
Kunori
T
T
Wachi
E
E
Wakasa
H
H
D006086:Graft vs Host Disease / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D065227:Transfusion Reaction
D006684:HLA-DR Antigens; D017493:Leukocyte Common Antigens