[Results of clinical investigation of anti-nicotine drug patches].
The paper gives the results of clinical trials of antinicotinic therapeutical films containing anabasinum, cytisinum or their combination in equal ratios. They were used in 74 patients with chronic nicotinism. The level of the drug in a film was 1.5 gm. The mode of its application was to apply it to the gingiva beneath the upper lip. The biosoluble polymer carrier-based antinicotinic films are easy-to-use and rather effective in the control of smoking. The films produced effects in 75.8% of patients, including a full effect, i.e. a full refusal of smoking in 46.8%. The films in combination with cytisinum and anabasinum, or those with cytisinum alone was the most effective. There were no adverse reaction when the films were applied. The drug is well tolerated by patients with coronary heart disease, arterial hypertension, and diabetes mellitus.
Ostrovskaia
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D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000470:Alkaloids / Q000627:therapeutic use*; D000691:Anabasine / Q000627:therapeutic use*; D001392:Azocines; D004337:Drug Carriers; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011807:Quinolizines; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*; D016896:Treatment Outcome; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D000691:Anabasine; D001392:Azocines; D004337:Drug Carriers; D011807:Quinolizines; C004712:cytisine; D000093843:Quinolizidine Alkaloids
Rezultaty klinicheskogo izucheniia antinikotinovykh lekarstvennykh plenok.