[Protection against experimental hepatic injury by fengxiang yigankang capsule].
Protective effect of Fengxiang Yigankang (FXYGK) capsule against hepatotoxicity induced by CCl4 and acetaminophen (AAP) was studied. It was found that the FXYGK capsule inhibited markedly malonic aldehyde (MDA) formation of liver induced by CCl4 and AAP. It blocked also depletion of reduced form of glutathione (GSH) of damaged liver induced by AAP. In addition, FXYGK could decrease serum alanine aminotransferase levels induced by CCl4 (P < 0.05). The results of histopathological examination showed that the FXYGK capsule (0.45, 0.9 and 1.8 g/kg) could also reduce significantly fatty degeneration of liver (P < 0.05).
Cheng
T J
TJ
Lanzhou Medical College.
Qin
H
H
Zhang
P Y
PY
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002214:Capsules; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice
D002214:Capsules; D004365:Drugs, Chinese Herbal; D000082:Acetaminophen; D008315:Malondialdehyde; D000410:Alanine Transaminase; D005978:Glutathione