Persistent polyclonal B-cell lymphocytosis.
We document a case of persistent lymphocytosis in which the characteristic binucleated circulating lymphocytes were shown immunologically to be polyclonal B-cells. Cytogenetic and molecular studies failed to show a clonal population. A review of the literature on this rare condition, persistent polyclonal B-cell lymphocytosis, highlights an association with the female sex, HLA-DR7 antigen, smoking and raised levels of IgM, all of which were present in our patient.
Agrawal
S
S
Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, U.K.
Matutes
E
E
Voke
J
J
Dyer
M J
MJ
Khokhar
T
T
Catovsky
D
D
D001402:B-Lymphocytes / Q000473:pathology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008218:Lymphocytosis / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged