[Experimental comparison of the toxicity of radix Aconity Kusnezoffii and processed radix Aconity Kusnezoffii by different methods].
This paper deals with the effects of Radix Aconity Kusnezoffii and Radix Aconity Kusnezoffii processed by a new method of moistening and steaming, and by pharmacopoeial routine on acute toxicity, cardiac rhythm and respiration. The result shows that the Radix Aconity Kusnezoffii processed by new method No 1., which applies moistening in water for 48h and then heating with high pressure steam (68.65kPa, 115 degrees C) for 2h, has the advantages of lower toxicity, and lesser inhibitory effect on cardiac rhythm and respiration.
Ma
C
C
Nanjing College of Traditional Chinese Medicine.
Cai
B c
Bc
Cheng
L
L
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D005260:Female; D006358:Hot Temperature; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D017202:Myocardial Ischemia / Q000139:chemically induced; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration / Q000187:drug effects; D013678:Technology, Pharmaceutical
D004365:Drugs, Chinese Herbal