Morin hydrate protects cultured rat glomerular mesangial cells against oxyradical damage.
Cultured rat glomerular mesangial cells were damaged when exposed to oxyradicals generated either from xanthine oxidase plus hypoxanthine, or by superoxide radicals formed from menadione. Morin hydrate is an antioxidant extracted from yellow Brazil wood. When morin hydrate was added to cultured rat glomerular mesangial cells which were attacked by oxyradicals generated by xanthine oxidase plus hypoxanthine, the survival time of the cells was doubled. However, this protective effect of morin hydrate was less marked when the cells were attacked by menadione. Note that the protective effects of Trolox which is a polar analogue of vitamin E were miniscule relative to those of morin hydrate with both oxidants.
Zeng
L H
LH
Department of Clinical Biochemistry, University of Toronto, Ontario, Canada.
Fung
K P
KP
Wu
T W
TW
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D002839:Chromans / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D005609:Free Radicals; D005920:Glomerular Mesangium / Q000166:cytology / Q000187:drug effects*; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D008854:Microscopy, Electron; D051381:Rats; D017382:Reactive Oxygen Species / Q000494:pharmacology*; D013481:Superoxides / Q000494:pharmacology; D014812:Vitamin K / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000378:metabolism; D047309:Flavones
D000975:Antioxidants; D002839:Chromans; D005419:Flavonoids; D005609:Free Radicals; D019271:Hypoxanthine; D007042:Hypoxanthines; D017382:Reactive Oxygen Species; D013481:Superoxides; D014812:Vitamin K; D014969:Xanthine Oxidase; C008548:morin; D047309:Flavones; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid