title: Inhibition of T3-receptor binding by Nitrofen.
abstract: Lung development is controlled by various hormones, including thyroid hormone. The herbicide 2,4-dichlorophenyl-p-nitrophenyl ether (Nitrofen) induces lung hypoplasia in fetal rats, when administered to the mother during gestation. Nitrofen might be teratogenic by an anti-thyroid activity. The present study shows that Nitrofen decreases the binding of T3 to the alpha 1 and beta 1 form of the thyroid hormone receptor in a non-competitive way. Consequently, rat lung hypoplasia might result from the decreased binding of T3 to its receptor, via exposure to Nitrofen during fetal development.
authors.affiliation: Department of Pediatric Surgery, University of Rotterdam, The Netherlands.
authors.forename: A E
authors.initials: AE
authors.lastname: Brandsma
authors.forename: D
authors.initials: D
authors.lastname: Tibboel
authors.forename: I M
authors.initials: IM
authors.lastname: Vulto
authors.forename: J J
authors.initials: JJ
authors.lastname: de Vijlder
authors.forename: A A
authors.initials: AA
authors.lastname: Ten Have-Opbroek
authors.forename: W M
authors.initials: WM
authors.lastname: Wiersinga
mesh_terms: D000818:Animals; D002645:Chickens; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004926:Escherichia coli / Q000235:genetics; D005822:Genetic Vectors; D006540:Herbicides / Q000633:toxicity*; D008168:Lung / Q000187:drug effects / Q000196:embryology; D010647:Phenyl Ethers / Q000633:toxicity*; D051381:Rats; D011988:Receptors, Thyroid Hormone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D013974:Thyroxine / Q000378:metabolism*
chemical_list: D006540:Herbicides; D010647:Phenyl Ethers; D011988:Receptors, Thyroid Hormone; D011993:Recombinant Fusion Proteins; C007350:nitrofen; D013974:Thyroxine