[The hemodynamic effect on the spatial organization of atherosclerotic lesions in the human aorta. Topical differences in the fatty streaks and in the lipofibrous and fibrous plaques].
By means of light microscopy of whole-mounted membranous preparations and scanning electron microscopy differences of the three-dimensional organization in the fatty streaks, lipo-fibrous and fibrous plaques in proximal, distal and central parts were investigated. It was revealed that the central parts of the atherosclerotic lesions have a more mature character than the proximal and, especially, distal parts of the plaques. This phenomenon is accounted for by a progressive growth of the plaques along blood flow in distal direction due to the changes in hemodynamics.
Kolpakov
V A
VA
Solov'ev
P B
PB
Polishchuk
R S
RS
Bannykh
S I
SI
Mironov
A A
AA
D000328:Adult; D001011:Aorta / Q000503:physiopathology / Q000648:ultrastructure; D001018:Aortic Diseases / Q000473:pathology* / Q000503:physiopathology; D001161:Arteriosclerosis / Q000473:pathology* / Q000503:physiopathology; D016757:Death, Sudden, Cardiac / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D005355:Fibrosis; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged
Vliianie gemodinamiki na prostranstvennuiu organizatsiiu ateroskleroticheskikh porazheniĭ aorty cheloveka. Topicheskie otlichiia v lipidnykh polosakh, lipofibroznykh i fibroznykh bliashkakh.