Cytotoxic activity of two new lipophilic steroid nitrogen carbamates incorporated into low-density lipoprotein.
Low-density lipoprotein (LDL) is a potential drug carrier in cancer chemotherapy. Two novel cytotoxic lipophilic steroid derivatives with two nitrogen carbamate groups on a C-17 side chain were successfully incorporated into LDL using a reassembly technique. The antineoplastic activity of the new agents against T-47D breast cancer cells in culture was approximately twice that of a previously characterized compound with only one such group.
Lundberg
B
B
Department of Biochemistry and Pharmacy, Abo Akademi University, Finland.
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D002219:Carbamates / Q000008:administration & dosage* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004337:Drug Carriers; D015507:Drugs, Investigational / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008077:Lipoproteins, LDL / Q000008:administration & dosage*; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage* / Q000494:pharmacology*; D013256:Steroids / Q000008:administration & dosage* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; C090412:BMS 181095; D002219:Carbamates; D004337:Drug Carriers; D015507:Drugs, Investigational; D008077:Lipoproteins, LDL; D009588:Nitrogen Mustard Compounds; D013256:Steroids; C053328:N-(3-(oleoyloxy)androst-5-en-17-yl(pentyloxycarbonyl))-N-N-bis(2-chloroethyl)amine