title: The effects of 4-aminopyridine on cognitive function in patients with multiple sclerosis: a pilot study.
abstract: 4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function.
authors.affiliation: Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: R C
authors.initials: RC
authors.lastname: Smits
authors.forename: H H
authors.initials: HH
authors.lastname: Emmen
authors.forename: F W
authors.initials: FW
authors.lastname: Bertelsmann
authors.forename: B M
authors.initials: BM
authors.lastname: Kulig
authors.forename: A C
authors.initials: AC
authors.lastname: van Loenen
authors.forename: C H
authors.initials: CH
authors.lastname: Polman
mesh_terms: D015761:4-Aminopyridine / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D009483:Neuropsychological Tests; D010865:Pilot Projects; D010919:Placebos
chemical_list: D010919:Placebos; D015761:4-Aminopyridine