[Experimental study on the cardiotonic action of extract from Codonopsis pilosula (Franch.)Nannf].
Extracts of different concentrations from Codonopsis pilosula were administered to the myocardial cells of rats, and the results indicated that the activity of PDE was inhibited in different ways, and that cAMP was less hydrolyzed and increased in contents. When the extract was administered to the PRP of rabbits, the inhibiting rate of CaM activity rose with the increase of concentration in the extract.
Qin
L M
LM
Affiliated Dongzhimen Hospital, Beijing College of TCM.
Yan
Y F
YF
Wang
Z C
ZC
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002147:Calmodulin / Q000097:blood; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D002147:Calmodulin; D004365:Drugs, Chinese Herbal; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases