Monitoring of girls undergoing medical therapy for isosexual precocious puberty.
We evaluated the use of sonography in monitoring the efficacy of suppressive therapy with a gonadotropin releasing hormone analogue in girls being treated for isosexual precocious puberty. Ten girls 5 to 9 years of age underwent serial sonography and hormonal stimulation tests on the same day. Sonographic trends of decreasing ovarian volume and uterine length indicated early suppression even when absolute values were above threshold. Changes in ovarian volume were the most sensitive predictor of pituitary-gonadal suppression. Sonography is a sensitive and accurate method of monitoring medical therapy; ovarian volume and analysis of interval change are the most sensitive barometers of change.
Ambrosino
M M
MM
Department of Radiology, New York University Medical Center, Bellevue Hospital Center, New York.
Hernanz-Schulman
M
M
Genieser
N B
NB
Sklar
C A
CA
Fefferman
N R
NR
David
R
R
D002648:Child; D002675:Child, Preschool; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008137:Longitudinal Studies; D007986:Luteinizing Hormone / Q000032:analysis; D010053:Ovary / Q000000981:diagnostic imaging* / Q000187:drug effects*; D010902:Pituitary Gland / Q000187:drug effects; D011446:Prospective Studies; D011629:Puberty, Precocious / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging* / Q000187:drug effects*
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide