title: [The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study].
abstract: In 87 patients with chronic venous hypertensive microangiopathy the efficacy of oral FTTCA (Centella asiatica) administered for 60 days was tested. The microcirculatory effects of two dosages (30 mg bid and 60 mg bid) versus placebo was assessed in a double blind study. The compound was well tolerated and no unwanted effects were observed. Microcirculatory parameters--peri-malleolar skin flux at rest (RF) and transcutaneous PO2 and PCO2--improved as did the abnormally increased RF, PCO2 decreased and PO2 increased in comparison with values measured at inclusion. These results confirm the efficacy of FTTCA in venous hypertensive microangiopathy. Furthermore the effects of FTTCA appear to be dose-related.
authors.affiliation: Istituto di Clinica Cardiovascolare, Università degli Studi G. D'Annunzio, Chieti.
authors.forename: M R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: G
authors.initials: G
authors.lastname: Laurora
authors.forename: M T
authors.initials: MT
authors.lastname: De Sanctis
authors.forename: L
authors.initials: L
authors.lastname: Incandela
authors.forename: R
authors.initials: R
authors.lastname: Grimaldi
authors.forename: C
authors.initials: C
authors.lastname: Marelli
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010946:Plants, Medicinal; D011186:Postphlebitic Syndrome / Q000188:drug therapy / Q000503:physiopathology; D012867:Skin / Q000098:blood supply*; D014315:Triterpenes / Q000627:therapeutic use*; D014689:Venous Insufficiency / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D014315:Triterpenes
vernacular_title: Attività microcircolatoria della Centella asiatica nell'insufficienza venosa. Studio in doppio cieco.