Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery.
A total of 300 patients undergoing elective colorectal surgery over a 3-year period were randomly assigned to receive intraoperative peritoneal lavage with either taurolidine or saline. Culture swabs were taken from the region of surgery before and after lavage and the development of postoperative infection monitored. Of the positive culture swabs before lavage, a significantly higher proportion were negative after lavage with taurolidine than after that with saline. However, there was no difference in the incidence of postoperative infection between groups, suggesting that taurolidine intraoperative peritoneal lavage confers no clinical benefit over that with saline.
Baker
D M
DM
Department of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK.
Jones
J A
JA
Nguyen-Van-Tam
J S
JS
Lloyd
J H
JH
Morris
D L
DL
Bourke
J B
JB
Steele
R J
RJ
Hardcastle
J D
JD
D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D003106:Colon / Q000601:surgery*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D010533:Peritoneal Lavage; D012007:Rectum / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013829:Thiadiazines / Q000627:therapeutic use*
D000891:Anti-Infective Agents, Local; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine