Comparative findings on serum IMg2+ of normal and diseased human subjects with the NOVA and KONE ISE's for Mg2+.
It is clear now that although different ionophores for ionized Mg (IMg2+) have been designed by several groups, each of these has a distinctly different KMgCa. In view of this, it is important to determine whether each of these ion selective electrodes (ISE's) yield identical results for IMg2+ in sera from healthy and diseased humans. Using such an approach, we determined, in a blinded-and random manner, IMg2+ with both the NOVA and KONE ISE's for IMg2+ in two independent laboratories. No significant differences were found either for sera from healthy human volunteers or diseased patients. We did, however, note several interesting findings: 1. randomly, selected hospitalized patients exhibit a much higher incidence of abnormalities for IMg2+ (57-71%) than that noted previously for total Mg (TMg) measurements; and 2. coronary heart disease, rectal cancer and multiple sclerosis patients exhibit extracellular deficits in ionized free Mg.
Altura
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BT
Department of Physiology, State University of New York, Health Science Center at Brooklyn 11203.
Bertschat
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F
Jeremias
A
A
Ising
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H
Altura
B M
BM
D000368:Aged; D000369:Aged, 80 and over; D002413:Cations, Divalent; D003327:Coronary Disease / Q000097:blood; D005260:Female; D006801:Humans; D017736:Ion-Selective Electrodes; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood; D012004:Rectal Neoplasms / Q000097:blood
D002413:Cations, Divalent; D008274:Magnesium