title: Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis.
abstract: A dehydrogenation polymer of ferulic acid (DHP-FA), a synthetic lignin, was evaluated for its ability to inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the 7,12-dimethylbenz[a]anthracene-treated skin of female ICR mice. Topical application of DHP-FA inhibits TPA-induced tumor promotion, whereas a monomeric ferulic acid does not show the inhibitory effect.
authors.affiliation: Nagoya City Public Health Research Institute, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Asanoma
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Miyabe
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: N
authors.initials: N
authors.lastname: Yoshimi
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Kawazoe
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000287:Administration, Topical; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D003043:Cocarcinogenesis; D003373:Coumaric Acids / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal; D011108:Polymers / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate
chemical_list: D016588:Anticarcinogenic Agents; D003373:Coumaric Acids; D011108:Polymers; D015127:9,10-Dimethyl-1,2-benzanthracene; C004999:ferulic acid; D013755:Tetradecanoylphorbol Acetate