Insertional mutagenesis in transgenic mice.
Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.
Rijkers
T
T
Institute for Molecular Biology, Medical School Hannover, Germany.
Peetz
A
A
Rüther
U
U
D000818:Animals; D004247:DNA / Q000008:administration & dosage / Q000235:genetics; D005260:Female; D005804:Genes, Lethal; D005822:Genetic Vectors; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D008845:Microinjections; D016254:Mutagenesis, Insertional / Q000379:methods*; D009154:Mutation; D011247:Pregnancy; D012190:Retroviridae / Q000235:genetics
D004247:DNA