title: Exogenous testosterone differentially affects myelination and neurone soma sizes in the brain of canaries.
abstract: We assessed the temporal and functional relationship of myelin maturation and of neuronal development in the telencephalic song motor centres of the canary at different developmental stages. Brain differentiation was modulated by exogenous testosterone, its effects on song quality were also monitored. Myelin maturation was studied by using computer aided analysis of silver impregnated brain sections, whereas the differentiation of neurones was determined by measuring neuronal soma sizes. At an early developmental stage, testosterone triggers growth of neurones but does not affect myelination. At a later developmental stage, both neurone soma sizes and myelination are enhanced by testosterone.
authors.affiliation: Abteilung für Allgemeine Zoologie, Universität Kaiserslautern, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Stocker
authors.forename: H R
authors.initials: HR
authors.lastname: Güttinger
authors.forename: G
authors.initials: G
authors.lastname: Herth
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D002171:Canaries; D004343:Drug Implants; D008297:Male; D009186:Myelin Sheath / Q000187:drug effects* / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D009928:Organ Specificity; D012016:Reference Values; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*; D014828:Vocalization, Animal
chemical_list: D004343:Drug Implants; D013739:Testosterone