HLA and prognosis in multiple sclerosis.
The patients of a multiple sclerosis (MS) incidence cohort with 25 years of longitudinal follow-up were typed for HLA-DR and DQ. This type of cohort provides reliable data for gene frequencies and prognostic studies. The influence of sampling bias, mainly due to mortality during the long follow-up, was accounted for. A positive association between MS and DR15,DQ6 was confirmed, but this haplotype did not influence prognosis. There was no difference in haplotype frequency between relapsing-remitting and primary chronic progressive MS. DR17,DQ2 was significantly over-represented in the quartile with the most malignant course. The haplotype DR1,DQ5, which was found rather less frequently in MS patients, also tended to be associated with a poorer prognosis.
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Department of Neurology, Sahlgren's Hospital, Göteborg, Sweden.
Martinsson
T
T
Wahlström
J
J
Andersen
O
O
D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015993:Life Tables; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology* / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens