Intracellular translocation of rap 1-B G-protein induced by prostaglandin E1 is blocked by phorbol ester in human platelets.
Prostaglandin E1 induced increase in cytosolic immunoreactive rap 1-B G-protein in a time and concentration dependent manner in human platelets. However, this increase was completely blocked by simultaneous treatment of platelets with phorbol 12-myristate 13-acetate (PMA).
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Division of Medicinal Chemistry & Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536-0082.
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D000527:Alprostadil / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007106:Immune Sera; D011817:Rabbits; D015398:Signal Transduction / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D020668:rap GTP-Binding Proteins
D007106:Immune Sera; D019204:GTP-Binding Proteins; D020668:rap GTP-Binding Proteins; D000527:Alprostadil; D013755:Tetradecanoylphorbol Acetate