title: Bronchial asthma after early childhood wheezing: a follow-up until 4.5-6 years of age.
abstract: Over a period of 12 months from 1981 to 1982, 83 patients aged less than 2 years were treated in hospital for acute bronchiolitis. The children were followed-up prospectively; 68 (83%) completed the study until 4.5-6.0 years of age. At this age, 17 (25%) of the 68 children with bronchiolitis still suffered from wheezing attacks. These 17 asthmatics suffered from both atopic dermatitis (29 versus 6%) and allergic rhinitis (29 versus 8%) more frequently than non-asthmatic children. In contrast, positive results in the skin prick tests were almost equally common (29 and 20%) in asthmatic and non-asthmatic children. In these tests, allergies to birch pollen, timothy grass pollen and house dust mite were most common; asthma was particularly associated with house dust mite allergy. The presence of atopic dermatitis, elevated immunoglobulin E values and repeated wheezing episodes between 1 and 2 years of age were significant risk factors for later asthma. In conclusion, the risk for later asthma is increased after early childhood bronchiolitis; the frequency of asthma was 25% in the present study. Our results confirm that atopics are at a greater risk of developing asthma later in childhood than non-atopics; the risk was significant from 1 year of age onwards.
authors.affiliation: Department of Paediatrics, Kuopio University Hospital, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Kuikka
authors.forename: T
authors.initials: T
authors.lastname: Reijonen
authors.forename: K
authors.initials: K
authors.lastname: Remes
authors.forename: M
authors.initials: M
authors.lastname: Korppi
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D001988:Bronchiolitis / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000209:etiology; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012135:Respiratory Sounds; D012220:Rhinitis / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E