Antibacterial activity of metal complexes of benzil and benzoin thiosemicarbazones.
The metal (II) complexes of benzyl and benzoin thiosemicarbazones have been synthesized and characterized. They were studied for their antibacterial, antifungal and amoebicidal activity in vitro and for their toxicity in vivo. The ligands and their metal complexes exhibited low antibacterial and amoebicidal activity. The metal chelates of benzoin thiosemicarbazone seem to be the most active compounds.
Offiong
O E
OE
Department of Chemistry-University of Calabar, Nigeria.
Martelli
S
S
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004748:Entamoeba histolytica / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007928:Lethal Dose 50; D008670:Metals / Q000494:pharmacology*; D051379:Mice; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008670:Metals; D013882:Thiosemicarbazones