title: Sentinel hospital surveillance of HIV infection in Quebec. Quebec Sentinel Hospital HIV-Seroprevalence Study Group.
abstract: OBJECTIVE
  To measure the HIV seroprevalence rate in a surrogate sample of the general population in the province of Quebec, using a network of sentinel hospitals.
  
  
  METHODS
  Anonymous unlinked sentinel surveillance study.
  
  
  METHODS
  Outpatient surgery units in 19 acute care hospitals throughout Quebec.
  
  
  METHODS
  All patients attending the outpatient surgery units from November 1990 to October 1992. A total of 61,547 plasma samples were obtained from leftover blood samples collected for cell counts. Fifty samples were excluded because of an insufficient amount of plasma and one because of an indeterminate result.
  
  
  METHODS
  HIV antibody testing with enzyme-linked immunosorbent assay; positive results confirmed with radioimmunoprecipitation assay.
  
  
  METHODS
  HIV antibody status, sex, year of birth and area of residence.
  
  
  RESULTS
  The crude seroprevalence rate among the subjects aged 15 years or more was 0.4 per 1000 population (95% confidence interval [CI] 0.2 to 0.7) among the women and 3.6 per 1000 population (95% CI 2.8 to 4.4) among the men (p < 0.001). The rate after adjustment for age, sex and geographic distribution of the study population was 2.3 per 1000 population (95% CI 1.9 to 2.7). The seroprevalence rate among the male patients in the City of Montreal was much higher than the rates elsewhere in the province. It increased progressively during each of the four 6-month intervals of the study: 8.1, 8.7, 13.9 and 18.3 per 1000 respectively (chi 2 linear trend = 4.76; p = 0.029). No similar trends were observed outside Montreal for the male patients. There were too few seropositive female patients to draw any solid conclusion.
  
  
  CONCLUSIONS
  Despite the possible drawbacks of a nonrandomized sampling scheme, this study suggests that in the male population the HIV seroprevalence rate is increasing in Montreal and is stable in all other areas of the province. The continued surveillance of HIV infection through anonymous unlinked studies is useful to monitor trends.
authors.affiliation: Université Laval, Centre de recherche, Hôpital du Saint-Sacrement, Quebec.
authors.forename: M
authors.initials: M
authors.lastname: Alary
authors.forename: J R
authors.initials: JR
authors.lastname: Joly
authors.forename: R
authors.initials: R
authors.lastname: Parent
authors.forename: M
authors.initials: M
authors.lastname: Fauvel
authors.forename: M
authors.initials: M
authors.lastname: Dionne
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D016001:Confidence Intervals; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D006679:HIV Seropositivity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D015528:HIV Seroprevalence; D006801:Humans; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital / Q000706:statistics & numerical data*; D011792:Quebec / Q000453:epidemiology; D018571:Sentinel Surveillance; D016036:Seroepidemiologic Studies; D012737:Sex Factors; D014505:Urban Population
chemical_list: D015483:HIV Antibodies