Structure-antifilarial activity relationship of 5/6/7/8-mono- or disubstituted 1H/1-phenyl-9H-pyrido[3,4-b]indoles--a new class of potential filaricides.
Antifilarial activity of 5/6/7/8-mono- or disubstituted 1 H/1-phenyl-9H-pyrido[3,4-b]indoles (I) has been described. The 1,6- and 8-substituted 9H-pyrido[3,4-b]indoles (I) elicited interesting filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae in rodent hosts.
Agarwal
A
A
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Agarwal
S K
SK
Singh
S N
SN
Fatma
N
N
Chatterjee
R K
RK
D000818:Animals; D004153:Dipetalonema / Q000187:drug effects*; D005369:Filaricides / Q000737:chemistry / Q000494:pharmacology*; D005370:Filarioidea / Q000187:drug effects*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009115:Muridae; D016205:Sigmodontinae; D013329:Structure-Activity Relationship
D005369:Filaricides; D007211:Indoles