title: Propofol--contrasting effects in movement disorders.
abstract: We report two patients presenting for thalamotomy in whom tremor was abolished for 8 h after propofol anaesthesia. Propofol has two contrasting actions. It may have an anti-Parkinsonion effect, abolishing abnormal limb movements. On other occasions, propofol is known to induce spontaneous abnormal limb movements, as well as epileptiform activity. Propofol is probably best avoided for stereotactic procedures. It is difficult to reconcile these two opposing actions.
authors.affiliation: Department of Anaesthesia, Auckland Hospital, Grafton, New Zealand.
authors.forename: B J
authors.initials: BJ
authors.lastname: Anderson
authors.forename: P V
authors.initials: PV
authors.lastname: Marks
authors.forename: M E
authors.initials: ME
authors.lastname: Futter
mesh_terms: D000771:Anesthesia, Intravenous; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000601:surgery*; D011183:Postoperative Complications / Q000601:surgery; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D012086:Reoperation; D013238:Stereotaxic Techniques; D013787:Thalamic Nuclei / Q000187:drug effects / Q000601:surgery*; D014202:Tremor / Q000601:surgery*
chemical_list: D015742:Propofol