Structural elucidation of two novel ergot alkaloid impurities in alpha-ergokryptine and bromokryptine.
Two novel natural derivatives (2 and 3) of the ergot alkaloid alpha-ergokryptine (1), as well as their synthetically brominated analogues (5 and 6) were isolated and identified by NMR and MS methods. Compounds 2 and 5 contain what appears to be a so far unknown natural amino acid building block. Complete 1H and 13C NMR assignments are given for compounds 1-6.
Szántay
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C
Chemical Works of Gedeon Richter Ltd., Budapest, Hungary.
Bihari
M
M
Brlik
J
J
Csehi
A
A
Kassai
A
A
Aranyi
A
A
D001971:Bromocriptine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004340:Drug Contamination; D004873:Ergolines / Q000032:analysis*; D004876:Ergot Alkaloids / Q000032:analysis* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D004873:Ergolines; D004876:Ergot Alkaloids; D001971:Bromocriptine; C100269:ergocryptine