Reflex effects of lung inflation on tracheomotor tone observed during apnea produced by the Hering-Breuer reflex.
Reflex effects of static pressure lung inflation (SLI) on tracheomotor tone (TT) were studied during apnea produced by the Hering-Breuer expiratory-facilitatory reflex. Anesthetized dogs were placed on cardiopulmonary bypass, and diaphragm electromyogram was used as an indicator of central nervous system inspiratory output. Tracheomotor tone (TT) was reflexly produced by chemoreceptor stimulation. The volume and frequency of the ventilator [phasic lung inflation (PLI)] were adjusted to produce nearly a maximum reflex decrease in TT. The increase in TT observed while PLI was withheld (0 mmHg tracheal pressure) for 1-2 min was used as the control response. SLIs were interspersed among sets of PLIs. Although SLI produced apnea, TT returned toward the control TT recorded during 0 mmHg tracheal pressure. TT observed during apnea was reflexly sensitive to further increases in SLI and to changes in chemoreceptor stimulation, which also affected the time course of the tracheomotor responses. These results suggest that the reflex decrease in TT produced by SLI and the Hering-Breuer expiratory-facilitatory reflex are mediated by different central mechanisms but may be from the same or different pulmonary receptors.
Coon
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Department of Anesthesiology, Clement J. Zablocki Veterans Affairs Medical Center, Medical College of Wisconsin, Milwaukee 53295.
D000399:Air Pressure; D000818:Animals; D001049:Apnea / Q000503:physiopathology*; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D004576:Electromyography / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D012121:Respiration, Artificial; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology*; D014132:Trachea / Q000187:drug effects / Q000502:physiology*
D002245:Carbon Dioxide; D001285:Atropine