Recurrent sinus arrest in association with neuroleptic malignant syndrome.
We report a case of neuroleptic malignant syndrome where the catatonia clearly followed the administration of neuroleptics and where the neurovegetative disturbance was remarkably severe, including episodes of tracheal spasm, apnoea and episodes of bradycardia, and sinus arrest requiring insertion of a temporary external pacing wire. To our knowledge, such severe disturbance has not previously been reported.
Parry
A K
AK
Queen's Park Hospital, Blackburn.
Ormerod
L P
LP
Hamlin
G W
GW
Saleem
P T
PT
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002304:Cardiac Pacing, Artificial; D002389:Catatonia / Q000139:chemically induced; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects; D003006:Clopenthixol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis*; D009460:Neurologic Examination / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; C060342:clopenthixol acetate ester; D003006:Clopenthixol; D006220:Haloperidol; D002746:Chlorpromazine