Modulation of cell-mediated immunity by lithium chloride.
Immunomodulation of cell-mediated immunity was studied in mice treated with either lithium chloride (LiCl), anti-CD8 monoclonal antibody or their combination. While 6-day LiCl treatment decreased the ability of their splenocytes to induce a local graft-versus-host reaction--anti-CD8 abolished this effect. The proliferative response of spleen cells from those three groups of mice to concanavalin A stimulation in vitro was significantly increased. The natural killer (NK) cell toxicity of the mice was decreased by over 43% after the 6-day LiCl treatment, but was x 2.5 higher then the control value after a longer 21-d treatment. These results indicate that the immunomodulatory capacity of lithium is dependent on the type of cell population studied, and on the schedule of administration.
Kubera
M
M
Department of Immunology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
Bubak-Satora
M
M
Holan
V
V
Krol
W
W
Basta-Kaim
A
A
Roman
A
A
Skowron-Cendrzak
A
A
Shani
J
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D016827:CD8 Antigens / Q000276:immunology / Q000502:physiology; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006087:Graft vs Host Reaction / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D018021:Lithium Chloride / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008223:Lymphoma; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity; D013154:Spleen / Q000201:enzymology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D016827:CD8 Antigens; D018021:Lithium Chloride