title: Nodular sarcoidosis of the liver and spleen: appearance on MR images.
abstract: Small nodular lesions in the liver and spleen have been reported as an infrequent manifestation of sarcoidosis. Five patients with this appearance on either dynamic contrast material-enhanced computed tomographic (CT) or ultrasound scans underwent magnetic resonance (MR) imaging with and without dynamic gadolinium enhancement. The lesions were relatively uniform in size, ranging from 0.5 to 1.5 cm. On CT scans, they were hypoattenuating relative to surrounding parenchyma. On MR images, the lesions were hypointense relative to background parenchyma with all sequences. No substantial enhancement was observed in the lesions, although lesion conspicuity decreased over time on serial postcontrast images. Lesion conspicuity was greatest on either T2-weighted fat-suppressed (T2FS) images or early-phase dynamic contrast-enhanced images. Abdominal adenopathy was seen in three of the five patients and was hyperintense relative to liver on T2FS images in two and intermediate in intensity in one patient.
authors.affiliation: Department of Radiology, University of North Carolina School of Medicine, Chapel Hill 27599-7510.
authors.forename: D M
authors.initials: DM
authors.lastname: Warshauer
authors.forename: R C
authors.initials: RC
authors.lastname: Semelka
authors.forename: S M
authors.initials: SM
authors.lastname: Ascher
mesh_terms: D000328:Adult; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006529:Hepatomegaly / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D007089:Image Enhancement; D007472:Iohexol; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011856:Radiographic Image Enhancement; D012507:Sarcoidosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013154:Spleen / Q000473:pathology; D013158:Splenic Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013163:Splenomegaly / Q000175:diagnosis / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D007472:Iohexol; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA