Cellulose acetate butyrate and polycaprolactone for ketoprofen spray-dried microsphere preparation.
Ketoprofen-loaded microspheres made with a polymeric blend were prepared by a spray-drying technique. Organic solutions of two polymers, cellulose acetate butyrate (CAB) and poly(epsilon-caprolactone) (PCL), in different weight ratios, and of ketoprofen (Ket) were prepared and sprayed, in different experimental conditions, achieving drug-loaded microspheres. The obtained spray-dried microspheres were characterized in terms of yield of production, shape, size, surface properties and drug content, and their in vitro drug release behaviours were determined at different pH values.
Giunchedi
P
P
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
Conti
B
B
Maggi
L
L
Conte
U
U
D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007660:Ketoprofen / Q000008:administration & dosage* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013499:Surface Properties; D013696:Temperature
D011091:Polyesters; C016240:polycaprolactone; D002482:Cellulose; C014396:cellulose acetate-butyrate; D007660:Ketoprofen