title: Actuarial versus actual risk of porcine structural valve deterioration.
abstract: Actuarial analysis, using nonparametric (e.g., life table or Kaplan-Meier) or parametric (statistical modeling) methods, is used to describe and compare survival probabilities by allowing for partial survival times (censoring). Although devised to describe freedom from death, this method has been extended to nonfatal complications, such as freedom from tissue valve failure. However, the risk described for nonfatal events is that which a patient would experience provided he were immortal. And patients with valve disease have a relatively high risk of dying, generating the question: "What is the chance the valve will fail before the patient dies?" To answer this more practical (for individual patient management and population resource allocation) question requires an estimate of what we call actual failure, that is, the percentage of patients whose valve will actually fail before they die. This risk is less than the risk which the usual actuarial curve describes. This difference increases with patient age, because older patients have a lower risk of tissue failure and a higher risk of death than younger patients.
authors.affiliation: St. Vincent Heart Institute, Sisters of Providence Health System, Portland, Ore 97225.
authors.forename: G L
authors.initials: GL
authors.lastname: Grunkemeier
authors.forename: W R
authors.initials: WR
authors.lastname: Jamieson
authors.forename: D C
authors.initials: DC
authors.lastname: Miller
authors.forename: A
authors.initials: A
authors.lastname: Starr
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001021:Aortic Valve; D001705:Bioprosthesis; D005260:Female; D006350:Heart Valve Prosthesis / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D011475:Prosthesis Failure; D012306:Risk; D016019:Survival Analysis; D013552:Swine