title: Telehygiene system for preventive chronopharmacology in space and remote areas on earth.
abstract: A chronobiologic computerized modular health care (telehygiene) system for humans in extraterrestrial space 1) monitors and analyzes physiologic blood pressure, heart rate and other variation, including that in tumor markers; 2) recognizes earliest risk elevation by dynamic changes in the 'usual value' range (trend and rhythm alteration); 3) prompts timely and timed treatment for cardiovascular and emotional disease and malignancy prevention, and 4) serves for health improvement; the information from the system can also help optimize shift-work schedules for peak performance and provides endpoints of interest in basic science. The system exploits the chronome, a genetically anchored, habitat-synchronized structure of multifrequency rhythms and trends which is now documented (by longitudinal data series) to respond to magnetic disturbance in the solar system, with consequences expressed in catastrophic illness that is best prevented. Such a system, rated by peers as being of highest priority, could complement classical tools such as the stethoscope, proposed by the U.S. Johnson Space Center representative for use on the moon.
authors.affiliation: University of Minnesota, Minneapolis.
authors.forename: F
authors.initials: F
authors.lastname: Halberg
authors.forename: G
authors.initials: G
authors.lastname: Cornélissen
authors.forename: Y
authors.initials: Y
authors.lastname: Kumagai
authors.forename: C
authors.initials: C
authors.lastname: Bingham
authors.forename: J
authors.initials: J
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Otsuka
authors.forename: T
authors.initials: T
authors.lastname: Breus
authors.forename: S
authors.initials: S
authors.lastname: Rapoport
authors.forename: F
authors.initials: F
authors.lastname: Komarov
mesh_terms: D000337:Aerospace Medicine / Q000379:methods*; D018480:Astronauts; D002909:Chronobiology Phenomena; D006801:Humans; D010600:Pharmacology; D011314:Preventive Health Services / Q000379:methods*; D017216:Telemedicine; D014481:United States; D018557:United States National Aeronautics and Space Administration