Indolocarbazole protein kinase C inhibitors from rebeccamycin.
Structural modifications were carried out on rebeccamycin, an antitumour antibiotic, to obtain analogues. The inhibitory potencies of these analogues against protein kinase C are compared. The method described represents an alternative route to the staurosporine aglycone, a potent protein kinase C inhibitor.
Fabre
S
S
Université Blaise Pascal, Laboratoire de Chimie Organique Biologique, URA 485, Aubière, France.
Prudhomme
M
M
Sancelme
M
M
Rapp
M
M
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007211:Indoles; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D002227:Carbazoles; D007211:Indoles; C053339:rebeccamycin; D011493:Protein Kinase C