title: [Hepatitis B and C virus mutants--clinical relevance].
abstract: Hepatitis B virus (HBV) mutants and hepatitis C virus (HCV) genotypes have recently been identified in patients with acute and chronic infections. Mutations may be associated with a specific clinical course of infection, e.g. chronic active or fulminant-hepatitis as well as the development of hepatocellular carcinoma (HCC). Further, mutations may affect clearance of HBV or HCV infection and the response to antiviral therapy with alpha-interferon; however, the exact contribution of specific mutations organotypes to the course of HBV or HCV infection remains to be established.
authors.affiliation: Departement für Innere Medizin, Universitätsspital Zürich.
authors.forename: H E
authors.initials: HE
authors.lastname: Blum
mesh_terms: D016679:Genome, Viral; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics*; D006526:Hepatitis C / Q000235:genetics / Q000276:immunology; D006801:Humans; D009154:Mutation
vernacular_title: Hepatitis-B- und -C-Virus-Mutanten--klinische Relevanz.