title: Brain and spinal cord revascularization by omental transposition.
abstract: It has been learned over the years that placement of the pedicled omentum onto the brain and the spinal cord results in the rapid development of blood vessels that penetrate directly, vertically and deeply into the underlying CNS structure. Rapid clinical changes in some patients following omental transposition to the CNS raised the question as to whether the changes might be due not only to increased vascular perfusion, but to neurochemicals within omental tissue. Subsequent studies have shown that the omentum incorporates in its tissue neurotransmitters, nerve growth substances, gangliosides and angiogenic factors of high activity. These neurochemical and angiogenic substances are undoubtedly involved in some manner in the ability of axons in a transected spinal cord to grow at 1 mm/day and apparently make appropriate connections with distal spinal cord target tissue.
authors.affiliation: Department of Neurosurgery, Boston University School of Medicine, MA 02118.
authors.forename: H S
authors.initials: HS
authors.lastname: Goldsmith
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D002415:Cats; D002536:Cerebral Arteries / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D002941:Circle of Willis / Q000473:pathology; D004285:Dogs; D004594:Electrophysiology; D000882:Haplorhini; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D009852:Omentum / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*
chemical_list: D018377:Neurotransmitter Agents