title: [Effect of carboplatin on the pharmacokinetics of melphalan administered intravenously].
abstract: In order to perform melphalan dosage adjustment, the linearity of melphalan kinetics was studied, in the case of previous carboplatin administration. Eleven patients with various solid tumors entered the present study. Carboplatin was administered during 5 days over 1-hour infusions; the day after, the melphalan test-dose was administered and followed 24 hours after by the complement dose. Melphalan kinetics were determined from only three plasma samples by using bayesian estimation. The present study showed that previous carboplatin administrations induced wide variations of melphalan pharmacokinetic parameters between the two administrations. As part of this protocol, the order of drug administration should be taken into account, in order to perform melphalan dosage adjustment.
authors.affiliation: Centre Léon-Bérard, Lyon, France.
authors.forename: B
authors.initials: B
authors.lastname: Tranchand
authors.forename: C
authors.initials: C
authors.lastname: Ardiet
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.forename: P
authors.initials: P
authors.lastname: Biron
authors.forename: I
authors.initials: I
authors.lastname: Philip
authors.forename: F
authors.initials: F
authors.lastname: Nasri
authors.forename: M
authors.initials: M
authors.lastname: Brunat-Mentigny
mesh_terms: D000293:Adolescent; D000328:Adult; D016190:Carboplatin / Q000008:administration & dosage / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009369:Neoplasms / Q000188:drug therapy; D013997:Time Factors
chemical_list: D016190:Carboplatin; D008558:Melphalan
vernacular_title: Effet du carboplatine sur la pharmacocinétique du melphalan administré par voie intraveineuse.