title: Monoclonal immunoglobulin deposition disease: a review of immunoglobulin chain alterations.
abstract: Monoclonal immunoglobulin deposition disease, a complication of overtly malignant or apparently benign immunoproliferative disorders, is a severe disease featuring tissue deposition of monoclonal light, light and heavy, or heavy chains. A number of converging arguments strongly suggest a direct pathogenetic role of structural abnormalities or peculiarities of variables regions of light and/or heavy chains (associated with deletions in the constant region for the heavy chains). Recent structural data on these abnormal immunoglobulin chains are reviewed.
authors.affiliation: Laboratory of Immunology and Immunopathology (CNRS URA 1172, Immunology and Molecular Interactions), Poitiers, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Preud'homme
authors.forename: P
authors.initials: P
authors.lastname: Aucouturier
authors.forename: G
authors.initials: G
authors.lastname: Touchard
authors.forename: A A
authors.initials: AA
authors.lastname: Khamlichi
authors.forename: A
authors.initials: A
authors.lastname: Rocca
authors.forename: L
authors.initials: L
authors.lastname: Denoroy
authors.forename: M
authors.initials: M
authors.lastname: Cogné
mesh_terms: D000686:Amyloidosis / Q000276:immunology; D006362:Heavy Chain Disease / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry*; D007147:Immunoglobulin Light Chains / Q000737:chemistry*
chemical_list: D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains