[Fetal outcome after local prostaglandin E2 administration in a risk patient group--comparison of morbidity with a normal patient sample].
Intracervical application of prostaglandin E2 gel is considered to be effective in the induction of cervical ripening (priming). Within an 2-years period 244 perinatal risk patients primed with PGE2 were compared with matched paired controls retrospectively. These 244 controls were matched for age, gestational age, parity, birth weight and maternal body mass index and delivered spontaneously. PGE2 gel (Prepidil) was administered intracervically. Basis criteria of perinatal quality, such as neonatal umbilical cord pH and APGAR-score were significantly (p < 0.01) worse in the patients treated with PGE2 gel. In the priming group cord pH was 7.28 (+/- 0.085) and 7.30 (+/- 0.070) in the control group. APGAR 1 min. was found to be 7.56 +/- 1.86 (priming) and 8.18 +/- 1.23 (control); APGAR 5 min. 8.56 +/- 0.90 (priming) and 8.78 +/- 0.54 (control). Contraction disorders, such as hyperactivity and dyscoordination, combined with cardiotocographic pathology was found in 42% (priming) and 19% (control) resp. Severe bradycardia occurred significantly more often in the priming group, whereas no differences were found concerning fever under labor and in puerperium.
Briese
V
V
Frauneklinik, Universität Rostock.
Falkert
U
U
Müller
H
H
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000282:Administration, Intravaginal; D000328:Adult; D001034:Apgar Score; D002585:Cesarean Section; D015232:Dinoprostone / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005782:Gels; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced / Q000379:methods*; D016555:Matched-Pair Analysis; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors
D005782:Gels; D015232:Dinoprostone
Fetal outcome nach lokaler Prostaglandin E2-Applikation in einem Risikokollektiv--Annäherung an die Morbidität des Normalkollektivs.