Translocations in 7q22 define a critical region in uterine leiomyomata.
Rearrangements involving the long arm of chromosome 7 in uterine leiomyoma are widely recognized and comprise one of the major cytogenetic subgroups of these tumors. To approach a molecular genetic investigation of this subgroup for identification of a gene(s) involved in the biology of uterine leiomyomata we have analyzed breakpoints in the del(7q) subgroup in a series of myomas karyotyped in our laboratory. Herein we report the cytogenetic analysis of 11 uterine leiomyomata: eight with interstitial deletions in the long arm of chromosome 7 and three with translocations in 7q. These translocations provide further support for 7q22 as the critical band in the del(7q) subgroup.
Sargent
M S
MS
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Weremowicz
S
S
Rein
M S
MS
Morton
C C
CC
D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*