Co-stimulation with LFA-1 triggers apoptosis in gamma delta T cells on T cell receptor engagement.
Stimulation of T cells through the T cell receptor (TcR) initiate activation pathways, and paradoxically can also result in activation-induced cell death. Many factors influence a stimulated cell's decision to manifest one or the other. Here we show that co-stimulation with LFA-1 plays a key role in the choice between the two fates, differentiating between alpha beta and gamma delta T cells. Peripheral gamma delta. T cells but not alpha beta T cells undergo apoptosis upon co-cross-linking of TcR and LFA-1 in MRL lpr/lpr mice as well as +/+ mice. Our results suggest that apoptosis of gamma delta T cells is inducible by combined stimuli independent of the Fas-mediated pathway.
Matsumoto
Y
Y
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Hiromatsu
K
K
Sakai
T
T
Kobayashi
Y
Y
Kimura
Y
Y
Usami
J
J
Shinzato
T
T
Maeda
K
K
Yoshikai
Y
Y
D000818:Animals; D017209:Apoptosis; D004249:DNA Damage; D005260:Female; D008099:Liver / Q000166:cytology; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation; D016169:Lymphocyte Function-Associated Antigen-1 / Q000008:administration & dosage*; D051379:Mice; D008817:Mice, Mutant Strains; D011940:Receptor Aggregation; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
D016169:Lymphocyte Function-Associated Antigen-1; D016692:Receptors, Antigen, T-Cell, gamma-delta