title: Cocaine-induced increases in EEG alpha and beta activity: evidence for reduced cortical processing.
abstract: To understand the effects of cocaine on the cerebral cortex, 14 male polydrug abusers were enrolled in a study on the effects of cocaine on the electroencephalogram (EEG). The experimental treatments were placebo, 20 mg cocaine or 40 mg cocaine i.v. administered in a double-blind, pseudorandom design. The EEG was recorded from 13 electrode positions over the left hemisphere during a 3-minute baseline recording and for 30 minutes after initiation of the i.v. injection. The spectral power for delta, theta, alpha and beta EEG bands was calculated from data collected in each 3-minute interval. Cocaine significantly increased beta in frontal and central areas and enhanced alpha in frontal and temporal regions. Cocaine-induced increases in EEG beta power had a cortical distribution similar to those produced by barbiturates and benzodiazepines. As all of these drugs reduce cortical glucose metabolism, the increases in beta power may reflect a reduction in cortical neural activity.
authors.affiliation: Medical Affairs Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland.
authors.forename: R I
authors.initials: RI
authors.lastname: Herning
authors.forename: B J
authors.initials: BJ
authors.lastname: Glover
authors.forename: B
authors.initials: B
authors.lastname: Koeppl
authors.forename: R L
authors.initials: RL
authors.lastname: Phillips
authors.forename: E D
authors.initials: ED
authors.lastname: London
mesh_terms: D000328:Adult; D000513:Alpha Rhythm / Q000187:drug effects*; D000704:Analysis of Variance; D001611:Beta Rhythm / Q000187:drug effects*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D003042:Cocaine / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D008297:Male
chemical_list: D003042:Cocaine