title: Immunological characteristics of umbilical cord blood cells: phenotypic and functional analysis.
abstract: The purpose of this study was to phenotype and assay immunological function on cord blood from 70 samples. Immunophenotyping indicated similar numbers of CD2, 3, and 8-positive cells as in adult bone marrow. CD4-positive cells were increased and CD19, 20, and CD56-positive cells were decreased in numbers. Proliferative responses to nonspecific mitogens were lower in cord blood cells than in adult cells, as was NK activity and spontaneous secretion of IL-6 and TNF-alpha. This study confirms the relative immaturity of cord blood cells even when some functional assays appear normal.
authors.affiliation: Laboratoire d'Immunologie, Centre de Transfusion Sanguine, Besancon, France.
authors.forename: E
authors.initials: E
authors.lastname: Racadot
authors.forename: J P
authors.initials: JP
authors.lastname: Schaal
authors.forename: P
authors.initials: P
authors.lastname: Van Lemmens
authors.forename: M
authors.initials: M
authors.lastname: Billot
authors.forename: P
authors.initials: P
authors.lastname: Herve
mesh_terms: D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D015703:Antigens, CD / Q000032:analysis; D001854:Bone Marrow Cells; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000378:metabolism; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000276:immunology*; D008934:Mitogens / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D015850:Interleukin-6; D008934:Mitogens; D014409:Tumor Necrosis Factor-alpha