title: [A patient with adult T cell leukemia in smoldering stage expressing an aberrant phenotype of CD3- and CD4+].
abstract: This report is of a patient with adult T cell leukemia (ATL) in the smoldering stage showing expression an aberrant phenotype of CD3-, CD4+ and CD8-. A 71-year-old woman was admitted to our hospital in December 1992, because of skin eruption and persistent low grade fever. Laboratory examination showed a leukocyte count of 7,000/microliter with 29% abnormal lymphocytes. The diagnosis of ATL was made by the detection of serum anti-HTLV-I antibody and the monoclonal integration of HTLV-I proviral DNA in abnormal lymphocytes. ATL cells at diagnosis were CD3+, CD4+ and CD8+. However, one month later ATL cells lacked CD3 and CD8. Three color analysis showed that most of the CD25+ cells were CD3- and CD4+.
authors.affiliation: Department of Clinical Pathology, Kobe City General Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Nasu
authors.forename: H
authors.initials: H
authors.lastname: Matsubayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: R
authors.initials: R
authors.lastname: Matsuura
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Kasakura
mesh_terms: D000368:Aged; D017252:CD3 Complex / Q000032:analysis*; D015704:CD4 Antigens / Q000032:analysis*; D016827:CD8 Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D015458:Leukemia, T-Cell / Q000175:diagnosis*; D008214:Lymphocytes / Q000276:immunology; D010641:Phenotype
chemical_list: D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens