Cell damage in vitro following direct contact with fine particles of titanium, titanium alloy and cobalt-chrome-molybdenum alloy.
Fibroblastic cells in vitro were exposed to powders of titanium, titanium-aluminium-vanadium alloy and cobalt-chrome-molybdenum (Co-Cr-Mo) alloy, either in direct contact with the cells or separated from the cells by a microporous membrane. Fine particles of all the materials reduced cell growth when in direct contact with cells, but only the finest particles of Co-Cr-Mo alloy caused cell damage through the microporous membrane. This provides further evidence that there is a mechanism of cell damage in vitro which depends on a direct interaction between cells and particles and is largely independent of the chemical nature of the particle.
Evans
E J
EJ
Department of Anatomy, University of Wales College of Cardiff, UK.
D000497:Alloys; D000818:Animals; D002452:Cell Count / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D010316:Particle Size; D051381:Rats; D014025:Titanium / Q000633:toxicity*; D014800:Vitallium / Q000633:toxicity*
D000497:Alloys; D014800:Vitallium; C031462:titanium alloy (TiAl6V4); D014025:Titanium