A study of the comparative bioavailability of pyrimethamine-sulfadoxine obtained from two oral preparations.
The bioavailability of two oral preparations of pyrimethamine-sulfadoxine are compared in a randomised cross-over study. Pyrimethamine(PM)-sulfadoxine(SD) was given orally in a single dose to healthy male adults (SD 12 mgkg-1; PM 0.64 mgkg-1). For Fansidar(Hoffman-LaRoche) the mean AUC for PM and SD were; 0.47 mghl-1 and 45.4 mghl-1, and for Falcidin(Cosmos), the mean AUC for PM and SD were; 0.49 mg hl-1 and 42.9 mghl-1 respectively. There was no significant difference in bioavailability of PM or SD between the two preparations.
Murphy
S A
SA
Kenya Medical Research Institute/Wellcome Unit, Kilifi, Kenya.
Mberu
E
E
D000284:Administration, Oral; D000328:Adult; D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics* / Q000600:supply & distribution; D001682:Biological Availability; D004338:Drug Combinations; D006801:Humans; D008297:Male; D011739:Pyrimethamine / Q000097:blood / Q000493:pharmacokinetics* / Q000600:supply & distribution; D013413:Sulfadoxine / Q000097:blood / Q000493:pharmacokinetics* / Q000600:supply & distribution
D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine