title: L-741,494, a fungal metabolite that is an inhibitor of interleukin-1 beta converting enzyme.
abstract: gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin. It has a mol wt of 154 and an empirical formula of C7H6O4. We propose the name xylaric acid for this compound.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey 07065.
authors.forename: M J
authors.initials: MJ
authors.lastname: Salvatore
authors.forename: O D
authors.initials: OD
authors.lastname: Hensens
authors.forename: D L
authors.initials: DL
authors.lastname: Zink
authors.forename: J
authors.initials: J
authors.lastname: Liesch
authors.forename: C
authors.initials: C
authors.lastname: Dufresne
authors.forename: J G
authors.initials: JG
authors.lastname: Ondeyka
authors.forename: T M
authors.initials: TM
authors.lastname: Jürgens
authors.forename: R P
authors.initials: RP
authors.lastname: Borris
authors.forename: S
authors.initials: S
authors.lastname: Raghoobar
authors.forename: E
authors.initials: E
authors.lastname: McCauley
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000595:Amino Acid Sequence; D020170:Caspase 1; D002852:Chromatography, Ion Exchange; D003546:Cysteine Endopeptidases / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008666:Metalloendopeptidases / Q000737:chemistry*; D008969:Molecular Sequence Data; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013098:Xylariales / Q000378:metabolism*
chemical_list: D000085:Acetates; C089560:L 741494; D011753:Pyrones; D003546:Cysteine Endopeptidases; D020170:Caspase 1; D008666:Metalloendopeptidases