title: Regulation of lymphocyte activation by the cell-surface molecule CD22.
abstract: Accessory molecules play an important role in the regulation of lymphocyte activation mediated by the B-cell antigen receptor (BCR). CD22 is one such accessory molecule expressed on B-lineage cells. Here, Che-Leung Law and colleagues review current knowledge on the structure-function relationship between CD22 and the BCR, discuss the role of CD22 as a cell-adhesion molecule and suggest models for potential in vivo functions of CD22.
authors.affiliation: Dept of Microbiology, University of Washington, Seattle 98195.
authors.forename: C L
authors.initials: CL
authors.lastname: Law
authors.forename: S P
authors.initials: SP
authors.lastname: Sidorenko
authors.forename: E A
authors.initials: EA
authors.lastname: Clark
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000096:biosynthesis / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002118:Calcium / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000276:immunology; D006801:Humans; D037102:Lectins; D008213:Lymphocyte Activation / Q000276:immunology*; D051918:Sialic Acid Binding Ig-like Lectin 2; D015398:Signal Transduction / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; C497867:CD22 protein, human; D015815:Cell Adhesion Molecules; D037102:Lectins; D051918:Sialic Acid Binding Ig-like Lectin 2; D002118:Calcium