Central serotonergic hyperresponsivity in late-onset Alzheimer's disease.
The prolactin response to oral d-fenfluramine (30 mg) was measured in nine patients with late-onset Alzheimer's disease and in an elderly comparison group. The serotonin-mediated prolactin response was significantly greater in the patients with Alzheimer's disease than in the comparison group. This finding suggests that central serotonin responsivity is greater in Alzheimer's disease.
McLoughlin
D M
DM
Department of Psychiatry, Trinity College Medical School, St. James's Hospital, London, England.
Lucey
J V
JV
Dinan
T G
TG
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D013237:Stereoisomerism
D011985:Receptors, Serotonin; D005277:Fenfluramine; D012701:Serotonin; D011388:Prolactin