Plasminogen with type-I mutation in the Chinese Han population.
A functionally inactive plasminogen (PLG) variant, PLG M5, is polymorphic in the Japanese population and has a codon 601 mis-sense mutation (GCT for Ala to ACT for Thr), designated type-I mutation. The present study aimed to reveal whether the plasminogen with type-I mutation is present in the Chinese Han population. Among 104 healthy Chinese students, phenotype PLG AM5 was found in three subjects (2.9%), while 100 subjects were phenotype A and one was phenotype AA3. In the three subjects with PLG AM5, plasma concentrations of immunoreactive PLG were normal but PLG activities were decreased. Analysis using PCR and dot-blot hybridization with allele-specific oligonucleotide probes revealed the presence of the type-I mutation in the PLG gene of all three subjects with PLG AM5. The data indicate that PLG with type-I mutation is present in the Chinese Han population, possibly at a polymorphic frequency.
Li
L
L
Department of Medical Genetics, University of Tsukuba, Japan.
Kikuchi
S
S
Arinami
T
T
Kobayashi
K
K
Tsuchiya
S
S
Hamaguchi
H
H
D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002681:China; D017931:DNA Primers; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D015151:Immunoblotting; D008969:Molecular Sequence Data; D010958:Plasminogen / Q000235:genetics*; D017354:Point Mutation; D011110:Polymorphism, Genetic
D017931:DNA Primers; D010958:Plasminogen