title: [Signet-ring-cell adenoma of the thyroid: description of a case and review of the literature].
abstract: An occasional finding of a signet-ring cell type adenoma, occurring in a 81-year-old man, suffering from inoperable pharyngo-laryngeal carcinoma, is described. Multinodular thyroid parenchyma was excided in performing tracheostomy and histologically examined. On the basis of extensive morphological, histochemical and immunohistochemical observations and of reviewed literature, an unifying morphogenetic interpretation of the signet-ring cell transformation is proposed, with special reference to the pathogenesis of this cytotype and the significance of the cytostructural and cytometabolic characteristics. Problems related to the differential diagnosis and clinicopathological correlation are also discussed.
authors.affiliation: Servizio di Anatomia e Istologia Patologica, Ospedale E. Agnelli, USL 44, Pinerolo.
authors.forename: R
authors.initials: R
authors.lastname: Vigliani
authors.forename: D
authors.initials: D
authors.lastname: Galliano
authors.forename: M
authors.initials: M
authors.lastname: Iandolo
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D007822:Laryngeal Neoplasms; D008297:Male; D009378:Neoplasms, Multiple Primary; D010610:Pharyngeal Neoplasms; D013964:Thyroid Neoplasms / Q000473:pathology*; D014617:Vacuoles / Q000648:ultrastructure
vernacular_title: Adenoma di cellule ad anello con castone della tiroide: descrizione di un caso e revisione della letteratura.