[Effect of Saussurea lappa on gastric functions].
The patients with chronic superficial gastritis were selected in the study. The variation in gastric acidity output, serum gastrin and plasma somatostatin concentration were observed during the Saussurea lappa decoction (SLD) perfusion into the stomach. There was no significant changes in acidity output, serum gastrin and plasma somatostatin concentration after the perfusion of SLD (P > 0.05). Changes in gastric emptying and plasma motilin concentration were observed after oral administration of the SLD in 5 healthy volunteers. The time of gastric emptying was markedly shortened after oral administration of SLD (P < 0.01). A significant increase occurred in plasma motilin concentration at 30 min. after oral administration of SLD (P < 0.01). It revealed that SLD could accelerate the gastric emptying and increase the endogenous motilin release.
Chen
S F
SF
Second Hospital of China Medical University.
Li
Y Q
YQ
He
F Y
FY
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005746:Gastric Emptying / Q000187:drug effects*; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000097:blood*; D013004:Somatostatin / Q000097:blood
D004365:Drugs, Chinese Herbal; D005755:Gastrins; D013004:Somatostatin; D009037:Motilin