Protective action of omeprazole against gastric mucosal injury induced by hemorrhagic shock in rats.
The efficacy of omeprazole in preventing gastric mucosal injury induced by hemorrhagic shock in rats and the putative mechanisms involved in this effect were investigated in the present study. Omeprazole did not affect mean arterial blood pressure under both basal conditions and induction of hemorrhagic shock, but it evoked a marked increase in Alcian blue recovery from gastric preepithelial mucus. The morphometric analysis of histological sections revealed that omeprazole caused a significant reduction of hemorrhagic shock-induced damage of gastric mucosa. Ranitidine, used as the reference drug, failed to affect mean arterial blood pressure, Alcian blue recovery from gastric mucus, or hemorrhagic shock-induced damage of gastric mucosa. Both omeprazole and ranitidine exerted a significant inhibition of gastric acid output from anesthetized pylorus-ligated rats. Overall, the present results indicate that omeprazole is effective in protecting gastric mucosa from necrotic damage induced by hemorrhagic shock and suggest that an enhancement of gastric mucus secretion contributes to this protective action.
Blandizzi
C
C
Institute of Medical Pharmacology, University of Pisa, Italy.
Gherardi
G
G
Natale
G
G
Marveggio
C
C
Del Tacca
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009853:Omeprazole / Q000494:pharmacology / Q000627:therapeutic use*; D011899:Ranitidine / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*
D011899:Ranitidine; D009853:Omeprazole