Nocardiosis in HIV-positive patients: an autopsy study in West Africa.
BACKGROUND
There are many reports of nocardiosis associated with HIV infection in industrialized and developing countries, but its true prevalence is unknown.


METHODS
An autopsy study was performed of HIV-positive and HIV-negative patients dying on the general medical wards of a large hospital in Abidjan, Ivory Coast, in 1991.


RESULTS
247 HIV-positive adult cadavers were examined. 10 (4%) had nocardiosis of the lung, of whom 6 showed disseminated disease. 8 patients had one or more AIDS-defining pathologies, and 5 had nocardiosis as the main cause of death. Pulmonary tuberculosis was found in 87 cadavers (35%), giving a ratio of pulmonary nocardial to tuberculous disease of 1:9. No nocardiosis was seen in 42 HIV-negative cadavers.


CONCLUSIONS
This is the highest recorded prevalence of HIV-associated nocardiosis in a representative sample. The prevalence of nocardiosis varies geographically, and in zones where HIV-associated tuberculosis is common, it is possible that some patients diagnosed as smear-negative pulmonary tuberculosis actually have nocardiosis. A revised strategy of sputum examination with gram stain is suggested to detect nocardia.
Lucas
S B
SB
Department of Histopathology, University College London Medical School, UK.
Hounnou
A
A
Peacock
C
C
Beaumel
A
A
Kadio
A
A
De Cock
K M
KM
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000473:pathology; D000328:Adult; D001344:Autopsy; D003937:Diagnosis, Differential; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009617:Nocardia Infections / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D009616:Nocardia asteroides; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis