title: Molecular and functional aspects of PECAM-1/CD31.
abstract: Among vascular cell adhesion molecules, platelet-endothelial cell adhesion molecule (PECAM-1/CD31) has the distinctive feature of being expressed on several of the major cell types associated with the vascular compartment. This makes it uniquely positioned to mediate multiple and important cell-cell interactions involving platelets, leukocytes and endothelial cells. Thus, PECAM-1 may represent a potential target for new therapeutic agents directed at a variety of pathological states.
authors.affiliation: Dept of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104.
authors.forename: H M
authors.initials: HM
authors.lastname: DeLisser
authors.forename: P J
authors.initials: PJ
authors.lastname: Newman
authors.forename: S M
authors.initials: SM
authors.lastname: Albelda
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D019408:Platelet Endothelial Cell Adhesion Molecule-1
chemical_list: D000911:Antibodies, Monoclonal; D015214:Antigens, Differentiation, Myelomonocytic; D015815:Cell Adhesion Molecules; D019408:Platelet Endothelial Cell Adhesion Molecule-1