Fibroadenoma of the breast showing a translocation (6;14), a ring chromosome and two markers involving parts of chromosome 11.
The cytogenetic findings of a recurrent fibroadenoma of a 25-year-old woman are reported. Of 58 metaphases karyotyped after G-banding, 27 showed an apparently normal karyotype and 31 the karyotype 48,XX,del(6)(q21),r(11)(?) + der(11)x2,der(14)t(6;14)(q21;q32). By fluorescence in situ hybridization studies using a chromosome 11 specific painting probe, we were able to show that the two marker chromosomes and the ring contained chromosome 11 DNA.
Leuschner
E
E
Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.
Meyer-Bolte
K
K
Caselitz
J
J
Bartnitzke
S
S
Bullerdiek
J
J
D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002896:Chromosomes, Human, Pair 6; D005260:Female; D018226:Fibroadenoma / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D012303:Ring Chromosomes; D014178:Translocation, Genetic
D005819:Genetic Markers