[Age-associated changes in interleukin-1 receptors on bone marrow macrophages in ICR mouse and Wistar rat].
Receptor levels of interleukin-1 (IL-1) on bone marrow macrophages in ICR mouse and Wistar rat were measured chronologically using europium-labeled ligand assay. The IL-1 alpha bound to high and low affinity sites but IL-1 beta bound only to low affinity site on the macrophages in both mouse and rat. The Kd values of IL-1 alpha and IL-1 beta were gradually increased with age in both species, although the binding capacities (receptor number) of IL-1 alpha were low in young and aged mice. Binding capability of IL-1 beta decreased age-dependently. These results suggested that receptors of IL-1 on bone marrow macrophages of these species might decrease with age in both quality and quantity.
Futamura
Y
Y
Department of Pharmacology, Toho University School of Medicine, Tokyo, Japan.
Matsumoto
K
K
D000375:Aging / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D005260:Female; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017208:Rats, Wistar; D017472:Receptors, Interleukin-1 / Q000378:metabolism*
D017472:Receptors, Interleukin-1