Acetylenic and allenic derivatives of 2-(5-methoxy-1-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B.
A new series of thirty derivatives of 2-(5-methoxy-1-methylindolyl)alkylamines has been synthesized and the compounds assayed as inhibitors of MAO-A and MAO-B from bovine brain mitochondria. IC50 values for both isoenzymes were determined using tyramine as a common substrate. Structure-activity and selectivity relationships are discussed.
Fernández García
C
C
Instituto de Química Orgánica, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Marco
J L
JL
Fernández-Alvarez
E
E
D000114:Acetylene / Q000737:chemistry; D000588:Amines / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000588:Amines; D007211:Indoles; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D000114:Acetylene