title: The rate of increase in blood pressure in children 5 years of age is related to changes in aerobic fitness and body mass index.
abstract: OBJECTIVE
  To determine whether changes in aerobic fitness and body mass index are related to the age-related rise in blood pressure in healthy preschool children.
  
  
  METHODS
  Longitudinal analyses of 196 free-living children aged 5 years at baseline who were followed over a mean of 19.7 months. Aerobic fitness was assessed using a treadmill. All measures were obtained on multiple occasions at scheduled visits as part of a longitudinal cohort study.
  
  
  METHODS
  An inner-city medical center.
  
  
  METHODS
  Blood pressure was measured using an automated Dinamap device.
  
  
  RESULTS
  Mean systolic blood pressure was 95.3 mmHg (SD 8.38) at baseline and increased by 4.46 mmHg per year. Mean diastolic blood pressure was 53.9 mmHg (SD 5.81) at baseline and did not change significantly. Children in the highest quintile of increase in fitness had a significantly smaller increase in systolic blood pressure compared to children in the lowest quintile (2.92 vs 5.10 mmHg/year; P = .03). Children in the lowest quintile of increase in body mass index did not differ significantly in rate of increase in systolic blood pressure compared to children in the highest quintile (3.92 vs 4.96 mmHg/year). In a multiple regression model including baseline systolic blood pressure, fitness, height, body mass index, and other covariates, greater increase in fitness (P = .03) and lesser increase in body mass index (P < .01) were associated with lower rates of increase in systolic blood pressure. In a similar multivariate analysis, an increase in fitness was also associated with a lower rate of increase in diastolic blood pressure (P = .02).
  
  
  CONCLUSIONS
  Young children who increase their aerobic fitness or decrease their body mass index reduce the rate of the age-related increase in blood pressure. These observations may have implications for development of interventions directed at the primary prevention of hypertension.
authors.affiliation: Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY.
authors.forename: S
authors.initials: S
authors.lastname: Shea
authors.forename: C E
authors.initials: CE
authors.lastname: Basch
authors.forename: B
authors.initials: B
authors.lastname: Gutin
authors.forename: A D
authors.initials: AD
authors.lastname: Stein
authors.forename: I R
authors.initials: IR
authors.lastname: Contento
authors.forename: M
authors.initials: M
authors.lastname: Irigoyen
authors.forename: P
authors.initials: P
authors.lastname: Zybert
mesh_terms: D000367:Age Factors; D001794:Blood Pressure; D015992:Body Mass Index; D002675:Child, Preschool; D003971:Diastole; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D010809:Physical Fitness; D012044:Regression Analysis; D013599:Systole