title: Topical CTC-96 accelerates wart growth in rabbits infected with cottontail rabbit papillomavirus.
abstract: CTC-96, a cobalt containing complex, was tested as a putative topical therapeutic agent for the treatment of papillomavirus-induced tumors in our cottontail rabbit papillomavirus (CRPV)-rabbit model system. Following experimental infection of domestic rabbits with CRPV, CTC-96 was applied to infection sites twice daily, 5 days a week for a total of 8 weeks. Two levels of concentrations of aqueous CTC-96 were compared to placebo control-treated animals. With increasing dose of CTC-96 we observed tumors earlier, larger, and more often across eight infected sites on each animal.
authors.affiliation: Institute of Human Genetics, Medical School, University of Minnesota, Minneapolis 55455.
authors.forename: R S
authors.initials: RS
authors.lastname: Ostrow
authors.forename: S
authors.initials: S
authors.lastname: Coughlin
authors.forename: R C
authors.initials: RC
authors.lastname: McGlennen
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: D
authors.initials: D
authors.lastname: Zelterman
authors.forename: A J
authors.initials: AJ
authors.lastname: Faras
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D012777:Cottontail rabbit papillomavirus; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D009942:Organometallic Compounds / Q000633:toxicity*; D030361:Papillomavirus Infections / Q000188:drug therapy* / Q000821:virology; D011817:Rabbits; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000821:virology; D014860:Warts / Q000188:drug therapy* / Q000473:pathology / Q000821:virology*
chemical_list: D000998:Antiviral Agents; D009942:Organometallic Compounds; C089809:CTC 96