title: An immunohistological study of post-transfusion graft-versus-host disease (GVHD).
abstract: We reported clinicopathological, histopathological and immunohistological features of two suggestive cases with post transfusion graft-versus-host disease (GVHD) and examined. In addition, we have declared histopathologic characteristics of acute and chronic GVHD with literatural consideration. On the basis of a review of two cases, we came to the following conclusion; It is implied that early lymphoid proliferation may be useful to make a diagnosis of acute GVHD. Case 2 had pathological confirmation of acute GVHD in the liver and small intestine. In the liver, a damage of interlobular bile ducts and T lymphocytes infiltration close to ducts were the most specific feature of acute GVHD. From an immunohistological study in case 2, it was confirmed that abnormal expression of HLA-DR antigen and the appearance of activated T lymphocytes played an important role in the development of GVHD reaction in the liver.
authors.affiliation: Department of Pathology I, Fukushima Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hojo
authors.forename: Y
authors.initials: Y
authors.lastname: Kainuma
authors.forename: T
authors.initials: T
authors.lastname: Kunori
authors.forename: E
authors.initials: E
authors.lastname: Wachi
authors.forename: H
authors.initials: H
authors.lastname: Wakasa
mesh_terms: D006086:Graft vs Host Disease / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D065227:Transfusion Reaction
chemical_list: D006684:HLA-DR Antigens; D017493:Leukocyte Common Antigens