Photostability studies of ouabain, alpha-acetyldigoxin and digoxin in solid state.
Ouabain, alpha-acetyldigoxin and digoxin were subjected to irradiation using different light sources in crystalline state and their respective yields of photoproducts were determined densitometrically. alpha-Acetyldigoxin was found to be less stable than digoxin yielding a higher percentage of photoproducts under each light source examined. Ouabain showed photostability under the conditions of investigation.
Reisch
J
J
Institut für Pharmazeutische Chemie der Westfälischen Wilhelms-Universität, Münster, Germany.
Zappel
J
J
Rao
A R
AR
D000113:Acetyldigoxins / Q000737:chemistry / Q000528:radiation effects*; D004077:Digoxin / Q000737:chemistry / Q000528:radiation effects*; D004355:Drug Stability; D010042:Ouabain / Q000737:chemistry / Q000528:radiation effects*; D010777:Photochemistry; D014466:Ultraviolet Rays
D000113:Acetyldigoxins; D010042:Ouabain; D004077:Digoxin