title: Light microscopic, ultrastructural, and immunohistochemical examinations of two calcifying epithelial odontogenic tumors (CEOT) in a dog and a cat.
abstract: Two calcifying epithelial odontogenic tumors from a 10-year-old cross-breed dog and a 9-year-old cat were characterized histologically and electron microscopically. Important characteristics were plexiform to squamous epithelial structure, amyloid in the tumor tissue with partial calcification (Liesegang's rings), and a low rate of mitosis. The amyloid found in the tumors was subjected to immunohistochemical examination, using a series of antibodies (anti-AA, -AL, -AF, -ASc1, -AB, -cytokeratin, -vimentin, -desmin, -laminin). The exclusive reaction to anti-cytokeratin and anti-laminin suggests that the amyloid is of epithelial origin.
authors.affiliation: Institute of Veterinary Pathology, University of Munich, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Breuer
authors.forename: O
authors.initials: O
authors.lastname: Geisel
authors.forename: R P
authors.initials: RP
authors.lastname: Linke
authors.forename: W
authors.initials: W
authors.lastname: Hermanns
mesh_terms: D000682:Amyloid / Q000032:analysis; D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005887:Gingival Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D007150:Immunohistochemistry; D008297:Male; D008853:Microscopy; D008854:Microscopy, Electron / Q000662:veterinary; D009808:Odontogenic Tumors / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*
chemical_list: D000682:Amyloid