Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.
Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma. This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue. Laboratory evaluations disclosed normal electrolytes, hemograms and non-toxic serum MTX levels at the onset of the symptoms. Computed tomography of the brain was normal but electroencephalography showed focal theta and delta slow waves over the right temporal-parietal-occipital area. The neurological symptoms resolved completely within 72 h.
Kiu
M C
MC
Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, Peoples' Republic of China.
Liaw
C C
CC
Yang
T S
TS
Lai
G M
GM
Hsi
S N
SN
Lu
C S
CS
D000293:Adolescent; D001859:Bone Neoplasms / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000139:chemically induced*; D012516:Osteosarcoma / Q000188:drug therapy*
D002955:Leucovorin; D008727:Methotrexate