Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma.
Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.
Ensoli
B
B
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Gendelman
R
R
Markham
P
P
Fiorelli
V
V
Colombini
S
S
Raffeld
M
M
Cafaro
A
A
Chang
H K
HK
Brady
J N
JN
Gallo
R C
RC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000821:virology; D000818:Animals; D001483:Base Sequence; D002448:Cell Adhesion; D002460:Cell Line; D017364:Collagenases / Q000378:metabolism; D004789:Enzyme Activation; D016326:Extracellular Matrix Proteins / Q000502:physiology; D016222:Fibroblast Growth Factor 2 / Q000502:physiology*; D005353:Fibronectins / Q000502:physiology; D015696:Gene Products, tat / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D020780:Matrix Metalloproteinase 9; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D014066:Palatine Tonsil / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000473:pathology / Q000821:virology; D012867:Skin / Q000473:pathology; D054322:tat Gene Products, Human Immunodeficiency Virus
D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus; D016222:Fibroblast Growth Factor 2; D017364:Collagenases; D020780:Matrix Metalloproteinase 9