title: Rearrangement of immunoglobulin genes in chicken B cell development.
abstract: Immunoglobulin gene rearrangement in the chicken has evolved not to generate antibody diversity per se but to generate an immunoglobulin variable region which can be diversified by subsequent somatic gene conversion events. While the molecular mechanism of V(D)J recombination in chickens cannot be distinguished from that seen in other species, the way in which this recombination is regulated during chicken B lymphocyte development does differ from the more widely known models of gene rearrangement in humans and rodents. In this review we focus on these differences, relating V(D)J recombination to the progression of chicken B cell development in the bursa of Fabricius.
authors.affiliation: Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ratcliffe
authors.forename: K A
authors.initials: KA
authors.lastname: Jacobsen
mesh_terms: D000483:Alleles; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D001483:Base Sequence; D002645:Chickens; D004268:DNA-Binding Proteins; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics*; D018398:Homeodomain Proteins; D007107:Immune System / Q000166:cytology / Q000254:growth & development; D007136:Immunoglobulins / Q000235:genetics*; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D007136:Immunoglobulins; D011506:Proteins; C064655:V(D)J recombination activating protein 2; C064658:RAG-1 protein