Changes in debrisoquine hydroxylation capacity following liver surgery.
Liver transplantation or the surgical construction of portacaval shunts may radically alter an individual's debrisoquine hydroxylation capacity. Good clinical management should encompass a full awareness of such changing needs and problems in patients who undergo hepatic surgery.
Mitchell
S C
SC
Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
Shah
R R
RR
Clements
D G
DG
Smith
R L
RL
D000328:Adult; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006801:Humans; D006900:Hydroxylation; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects*
C012359:4-hydroxydebrisoquin; D003647:Debrisoquin