title: Synthesis and anthelmintic activity of 3-substituted 5-methylthio-isoxazoles.
abstract: Isoxazole derivatives have been shown to possess antiparasitic activity. In the present study, 3-substituted 5-methylthio-isoxazoles were synthesized and tested for anthelmintic activity, along with some other isoxazoles which have been reported but not tested earlier. Nine compounds (2a, 2b, 2e, 2g, 2u, 3a, 3b, 3e and 3f) showed activity against both A. ceylanicum and N. dubius in vitro. Twelve compounds (2a, 2b, 2d, 2e, 2f, 2h, 2l, 2n, 2o, 2u, 3d and 3e) showed activity against N. dubius in vivo, a parasite of veterinary importance.
authors.affiliation: Organon Research Centre, Calcutta, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Banerjee
authors.forename: S
authors.initials: S
authors.lastname: Bandyopadhyay
authors.forename: A K
authors.initials: AK
authors.lastname: Gayen
authors.forename: T
authors.initials: T
authors.lastname: Sengupta
authors.forename: A K
authors.initials: AK
authors.lastname: Das
authors.forename: G K
authors.initials: GK
authors.lastname: Chatterjee
authors.forename: S K
authors.initials: SK
authors.lastname: Chaudhuri
mesh_terms: D000722:Ancylostoma; D000724:Ancylostomiasis / Q000188:drug therapy / Q000523:psychology; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D006224:Cricetinae; D005260:Female; D006925:Hymenolepiasis / Q000188:drug therapy / Q000469:parasitology; D006926:Hymenolepis; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009351:Nematospiroides dubius; D009559:Nippostrongylus; D051381:Rats; D013237:Stereoisomerism; D017206:Strongylida Infections / Q000188:drug therapy / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D007555:Isoxazoles