The role of plasma arachidonic acid metabolites in the pathogenesis and the prognosis of Henoch-Schönlein purpura.
Henoch-Schönlein Purpura (HSP) involve small vessel inflammation. Arachidonate biochemical pathways play an important role in the pathogenesis of vascular inflammation. The aim of this study was to investigate the change in the ratio of plasma arachidonic acid metabolites in the patients with HSP and evaluate the association between clinical activity and prostanoid activity in the acute phase of HSP. Plasma prostaglandin E2 (PGE2)-like activities were found to be 7.2 +/- 0.8 ng/ml in control group (n = 12) while it was 5.3 +/- 0.6 ng/ml in the patients with HSP (n = 12). Plasma leukotriene C4 (LTC4)-like activities were found to be 16.0 +/- 1.1 ng/ml in control while it was 30.9 +/- 4.3 ng/ml in the patients. The differences of LTC4-like activities and the LTC4/PGE2 ratios between the HSP patients and the controls were significant (p < 0.01, p < 0.001 respectively), but no significant difference was found in PGE2-like activities. Plasma LTC4-like activity and LTC4/PGE2 ratio were also significantly increased in the patients with high clinical score (p < 0.05, p < 0.02 respectively). These results suggested that not only cyclooxygenase products but also LTs may play an important role in vascular inflammation. Therefore LTC4/PGE2 ratio must be taken into consideration in the pathogenesis and the prognosis of HSP.
Buyan
N
N
Gazi University, Faculty of Medicine, Department of Pediatric Nephrology, Ankara, Turkey.
Hasanoğlu
E
E
Oğuz
A
A
Ercan
S
S
D000293:Adolescent; D016718:Arachidonic Acid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D015232:Dinoprostone / Q000097:blood*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood* / Q000209:etiology; D017997:Leukotriene C4 / Q000097:blood*; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index
D015415:Biomarkers; D016718:Arachidonic Acid; D017997:Leukotriene C4; D015232:Dinoprostone