7-Chloro-4,6-dimethoxy-1(3H)-isobenzofuranone and basidalin: antibiotic secondary metabolites from Leucoagaricus carneifolia Gillet (basidiomycetes) [corrected].
Two antibiotic metabolites were isolated from cultures of Leucoagaricus carneifolia. Their structures were elucidated by spectroscopic methods. The first compound, 7-chloro-4,6-dimethoxy-1(3H)-isobenzofuranone [corrected] (1) had to our knowledge not been described from natural sources whereas the second, basidalin (2), is a known metabolite of L. naucina (H. Iinuma et al., 1983). 1 exhibits antibiotic activities with minimal inhibitory concentrations of 20 micrograms/ml against Botrytis cinerea, the most sensitive microorganism.
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Fachbereich Chemie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
Kuball
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Anke
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D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D001572:Benzofurans / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D015003:Yeasts / Q000187:drug effects
C090286:7-chloro-4,6-dimethoxy-1(3H)-isobenzofuranone; D000900:Anti-Bacterial Agents; D001572:Benzofurans; D005663:Furans; C038319:basidalin