Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. II. Isolation and physical-chemical characterization.
Glycothiohexide alpha was recovered from the fermentation broth of a "Sebekia" sp. by mixed solvent extraction, selective precipitation and adsorption chromatography on Diaion HP-20. The amount of glycothiohexide alpha present in the crude preparation was enriched by photolysis. Purification of glycothiohexide alpha was accomplished by repetitive countercurrent chromatography.
Northcote
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PT
Natural Products Research Section, American Cyanamid Company, Pearl River, New York 10965.
Williams
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Manning
J K
JK
Borders
D B
DB
Maiese
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WM
Lee
M D
MD
D000192:Actinomycetales / Q000737:chemistry* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D010455:Peptides; C089609:glycothiohexide alpha