[The effect of the synthetic antioxidant fenozan-K on the reproduction of dissociated conditioned reactions and on the phospholipid composition of Wistar and KM strain rats].
Male Wistar rats were trained to perform dissociated conditioned reactions with food reinforcement in norm and under the action of pentobarbital (15 mg/kg). Retrieval of the learned tasks was investigated after isolated injections of synthetic antioxidant phenozan-K (40 mg/kg) and in combination with pentobarbital (7.5 mg/kg). In contrast to the results obtained with KM rats, in Wistar rats the influence of the antioxidant on pentobarbital effects was not detected. Comparative study of brain phospholipid content in rats revealed significant distinctions between the strains after pharmacological influences. It was supposed that the effects of phenozan-K depended on the initial brain phospholipid content. This may be one of the reasons of phenozan-K-induced modifications of retrieval in KM but not Wistar rats.
Arkhipov
V I
VI
Arkhipova
G V
GV
Fedotova
I B
IB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000737:chemistry / Q000187:drug effects; D002855:Chromatography, Thin Layer; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004347:Drug Interactions; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D010666:Phenylpropionates / Q000494:pharmacology*; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012054:Reinforcement, Psychology
D000975:Antioxidants; D010666:Phenylpropionates; D010743:Phospholipids; D010424:Pentobarbital; C047854:fenozan
Vliianie sinteticheskogo antioksidanta fenozana-K na vosproizvedenie dissotsiirovannykh uslovnykh reakstiĭ i sostav fosfolipidov u krys linii Vistar i KM.