Influence of synthetic adjuvants on nonspecific resistance to infections.
Among the numerous synthetic compounds of the MDP series capable of acting as adjuvants of vaccines, some can also stimulate the resistance of mice to experimental bacterial infections when given alone as a single dose before the challenge. This increase in nonspecific resistance appears to be mainly related to a priming effect on phagocytic cells leading to an enhancement in responses to the bacterial challenge, such as bactericidal activity and release of cytokines. The mediators produced by monocytes and macrophages (TNF, IL-1) are known to exert a protective effect when given early at the beginning of infection. Moreover, TNF and muramyl peptides could exert a synergistic activity against a bacterial or fungal challenge.
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Laboratoire d'Immunopharmacologie, CNRS & Université Paris, France.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007239:Infections / Q000276:immunology*; D009504:Neutrophils / Q000187:drug effects; D010586:Phagocytes / Q000187:drug effects
D016207:Cytokines; D000119:Acetylmuramyl-Alanyl-Isoglutamine