title: The nephritogenic immune response.
abstract: The past year has witnessed continued advances along several fronts in understanding the initiation and effects of a nephritogenic immune response. New information on the major histocompatibility complex in autoimmunity suggests that major histocompatibility complex class I and class II expression is important in the initiation of the immune response. The complex pathways involved in the regulation of leukocyte recruitment in inflammation continue to unravel and the role of cytokines in these processes is being defined. The ability of antibodies directed against leukocyte adhesion molecules to attenuate inflammation in experimental glomerulonephritis opens up the possibility of new therapeutic agents for human disease. The need to reexamine the role of complement as an effector in immune renal disease is suggested by evidence of intrinsic renal complement component production. Recent information on the pathogenesis of renal scarring in crescentic glomerulonephritis suggests the importance of leukocyte-endothelial cell interaction and of delayed-type hypersensitivity in this process. The ability of the growth factors transforming growth factor-beta and platelet-derived growth factor to induce glomerulosclerosis has been documented in an innovative study using selective renal gene transfer. Finally, the potential importance of apoptosis of inflammatory cells as a mechanism limiting injury is a new focus of attention.
authors.affiliation: Renal Section, Boston University Medical Center Hospital, MA 02118.
authors.forename: Y M
authors.initials: YM
authors.lastname: O'Meara
authors.forename: J
authors.initials: J
authors.lastname: Feehally
authors.forename: D J
authors.initials: DJ
authors.lastname: Salant
mesh_terms: D000818:Animals; D000917:Antibody Formation; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D018836:Inflammation Mediators; D007668:Kidney / Q000276:immunology*; D008181:Lupus Nephritis / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators