title: Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility-sensitized MRI.
abstract: We studied activation of the human visual cortex (VC) using susceptibility-sensitized MRI at 1.5 Tesla. Three albinos and six healthy controls underwent a series of monocular and binocular photic flash stimulation. Monocular stimulation in albinos caused predominant contralateral activation with a small, well-delineated area in the anterior part of the VC in the ipsilateral hemisphere. This finding was consistent with a chiasmal crossing anomaly in albinism. All controls had symmetric patterns of activation during monocular stimulation. Functional MRI represents a promising method for evaluation of the visual pathways in humans.
authors.affiliation: Department of Neurology, University Hospitals of Cleveland, OH.
authors.forename: P
authors.initials: P
authors.lastname: Hedera
authors.forename: S
authors.initials: S
authors.lastname: Lai
authors.forename: E M
authors.initials: EM
authors.lastname: Haacke
authors.forename: A J
authors.initials: AJ
authors.lastname: Lerner
authors.forename: A L
authors.initials: AL
authors.lastname: Hopkins
authors.forename: J S
authors.initials: JS
authors.lastname: Lewin
authors.forename: R P
authors.initials: RP
authors.lastname: Friedland
mesh_terms: D000293:Adolescent; D000328:Adult; D000417:Albinism / Q000175:diagnosis / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D010775:Photic Stimulation; D014793:Visual Cortex / Q000033:anatomy & histology / Q000473:pathology / Q000503:physiopathology*