title: Cellular expression of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in normal kidney structures and in renal cancer. Possible significance in immune response and in the clinicopathological correlation.
abstract: In this study we investigated the presence of lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) on renal cell cancer in 16 patients who underwent nephrectomy. In all cases, normal renal tissues presented ICAM-1 on the parietal epithelial cells lining Bowman's capsule while neither the visceral epithelium nor the glomerular endothelium were stained. The epithelial proximal and distal tubular cells were stained poorly (5 +/- 3 positive tubular cross sections/mm2). No renal cells were stained by the monoclonal antibody for LFA-1. In contrast, in renal cancer tissue we found 6 cases, negative for ICAM-1 and the others positive with a mean number of positive tubular cross sections of 52 +/- 37/mm2. In 10 cases staining with LFA-1 antibody was negative, while for the other cases the mean number of positive tubular cross sections was 11 +/- 8/mm2. Our results suggest that the expression of ICAM-1 and LFA-1 on the surface of malignant cells may explain the unusual clinical aspects of renal cell carcinoma, its association with the immune system, and clarify certain aspects of immunotherapy.
authors.affiliation: Department of Urology, University of Pisa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Minervini
authors.forename: V
authors.initials: V
authors.lastname: Panichi
authors.forename: L
authors.initials: L
authors.lastname: Viganò
authors.forename: R
authors.initials: R
authors.lastname: Felipetto
authors.forename: V
authors.initials: V
authors.lastname: Gattai
authors.forename: M
authors.initials: M
authors.lastname: Cecchi
authors.forename: L
authors.initials: L
authors.lastname: Fiorentini
authors.forename: R
authors.initials: R
authors.lastname: Palla
mesh_terms: D002292:Carcinoma, Renal Cell / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D007668:Kidney / Q000737:chemistry* / Q000473:pathology; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D016169:Lymphocyte Function-Associated Antigen-1 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009392:Nephrectomy
chemical_list: D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1