title: Catheter ablation of ventricular tachycardia in 136 patients with coronary artery disease: results and long-term follow-up.
abstract: OBJECTIVE
  This study attempted to determine the feasibility and long-term efficacy of catheter ablation by means of either radiofrequency or direct current energy in a selected group of patients with coronary artery disease.
  
  
  BACKGROUND
  Catheter ablation of ventricular tachycardia has proved to be highly effective in patients with idiopathic and bundle branch reentrant ventricular tachycardia. In patients with coronary artery disease and recurrent sustained ventricular tachycardia resistant to medical antiarrhythmic management, the value of catheter ablation has not yet been established.
  
  
  METHODS
  One hundred thirty-six patients with coronary artery disease and one configuration of monomorphic sustained ventricular tachycardia underwent radiofrequency (72 patients) or direct current catheter ablation (64 patients). The mapping procedure to localize an adequate site for ablation included pace mapping during sinus rhythm, endocardial activation mapping, identification of isolated mid-diastolic potentials and pacing interventions during ventricular tachycardia.
  
  
  RESULTS
  Primary success was achieved in 102 (75%) of 136 patients (74% of 72 undergoing radiofrequency and 77% of 64 with direct current ablation). Complications were noted in 12% of patients. During a mean (+/- SD) follow-up period of 24 +/- 13 months (range 3 to 68), ventricular tachycardia recurred in 16% of patients.
  
  
  CONCLUSIONS
  Catheter ablation of ventricular tachycardia in coronary artery disease is feasible in patients with one configuration of monomorphic sustained ventricular tachycardia. There is no significant difference with respect to the type of energy applied. The follow-up data show that in a selected group of patients with coronary artery disease, catheter ablation offers a therapy alternative.
authors.affiliation: Department of Cardiology, University Hospital, Göttingen, Germany.
authors.forename: B D
authors.initials: BD
authors.lastname: Gonska
authors.forename: K
authors.initials: K
authors.lastname: Cao
authors.forename: A
authors.initials: A
authors.lastname: Schaumann
authors.forename: A
authors.initials: A
authors.lastname: Dorszewski
authors.forename: F
authors.initials: F
authors.lastname: von zur Mühlen
authors.forename: H
authors.initials: H
authors.lastname: Kreuzer
mesh_terms: D000328:Adult; D000368:Aged; D017115:Catheter Ablation / Q000009:adverse effects; D003327:Coronary Disease / Q000150:complications*; D004594:Electrophysiology; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome