Synthesis and properties of 1-aryl(pyrimidinyl)-piperazinylalkyl derivatives of ethyl 3-phenyl-7-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d] pyrimidine-5-carboxylate.
Synthesis of N-aryl (pyrimidinyl)piperazinylalkyl derivatives of ethyl 2,4-dioxo-1,2,3-4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate is reported. Some of the obtained compounds are pharmacologically active.
Sladowska
H
H
Department of Chemistry of Drugs, School of Medicine, Wroclaw, Poland.
Sieklucka-Dziuba
M
M
Staniak
L
L
Kleinrok
Z
Z
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants