[Serum and tissue levels of cefodizime in the pediatric patients].
We administrated cefodizime (40 mg/kg) to 13 patients with simple herniorrhaphy in the pediatric field and determined its concentrations in tissues and serums. The mean serum and tissue levels of cefodizime after administration were 43.1 +/- 13.3 micrograms/ml, and 23.1 +/- 6.4 micrograms/g, respectively, at 3 hours. Cefodizime concentrations of the tissue and serum were maintained at relatively high levels for many hours. The ratio of cefodizime concentrations in tissue to serum became high at 3 hours after administration, and this suggests that tissue concentrations decreased more slowly than serum levels, and cefodizime concentrations in tissue were maintained at fairly high levels over a long period. No side effects caused by cefodizime were observed. From pharmacokinetic and clinical observations, cefodizime appears to be a safe and effective injectable antibiotic for the treatment of infections in children.
Matsuura
K
K
First Department of Surgery, Kochi Medical School.
Ogata
T
T
Araki
K
K
Kaneko
A
A
Kawasaki
H
H
Kobayashi
M
M
Naoki
I
I
Namikawa
T
T
Andoh
T
T
Yamamoto
H
H
D001424:Bacterial Infections / Q000378:metabolism / Q000517:prevention & control; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D059685:Herniorrhaphy; D006801:Humans; D007223:Infant; D008297:Male; D010537:Peritoneum / Q000378:metabolism; D011292:Premedication; D014018:Tissue Distribution
D002439:Cefotaxime; C033356:cefodizime