title: Functional disability in early rheumatoid arthritis: description and risk factors.
abstract: OBJECTIVE
  To provide a description and identify risk factors for functional disability in early rheumatoid arthritis (RA).
  
  
  METHODS
  A cohort of 337 patients with early RA with disease duration under 5 years was constituted in 2 areas in France and The Netherlands. Examination included the Ritchie index, the presence of nodes and other extraarticular manifestations, and the erythrocyte sedimentation rate (ESR). The Health Assessment Questionnaire, adapted and validated in the French and Dutch languages, was used to assess functional disability.
  
  
  RESULTS
  The results allowed for the cross sectional description of a marked early functional disability, with a score of 1 (adjusted for disease activity variables) from the first year of the disease. Functional disability was increasing nonlinearly with the disease duration in a quadratic model. Disease activity variables, namely ESR and Ritchie index, were identified as other important components of functional disability.
  
  
  CONCLUSIONS
  Consequences for the early management of RA are underlined.
authors.affiliation: School of Public Health, University of Nancy, France.
authors.forename: F
authors.initials: F
authors.lastname: Guillemin
authors.forename: T
authors.initials: T
authors.lastname: Suurmeijer
authors.forename: B
authors.initials: B
authors.lastname: Krol
authors.forename: C
authors.initials: C
authors.lastname: Bombardier
authors.forename: S
authors.initials: S
authors.lastname: Briançon
authors.forename: D
authors.initials: D
authors.lastname: Doeglas
authors.forename: R
authors.initials: R
authors.lastname: Sanderman
authors.forename: W
authors.initials: W
authors.lastname: van den Heuvel
mesh_terms: D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires