[The clinical importance of histocompatibility antigens and their combinations in the diagnosis of chronic pyelonephritis].
Distribution of histocompatibility antigens and combinations thereof were investigated in citizens of St. Petersburg. All the examinees suffered from chronic pyelonephritis (CPN). The occurrence of antigens A1 and B17 in the patients was significantly high and associated with increased risk and etiological fraction. Combinations of antigens were frequently encountered in one locus: A1, A2, interlocus combinations A1, B5, A1, B7, A1, B17. Combinations of these antigens (especially A1 + B17) were indicative of high CPN risk. Frequent incidence of antigens A1, B7; A1, B5 may be due to the fact that in the above combinations they are responsible for higher CPN-risk. Increased incidence rate of antigens HLA-A1 and HLA-B17 evidences their involvement into CPN pathogenesis. Strong association of the disease with antigens A1, B17 seems to be typical for St. Petersburg citizens.
Kulaeva
N N
NN
Shulutko
B I
BI
D016009:Chi-Square Distribution; D002908:Chronic Disease; D005260:Female; D015234:HLA-A Antigens / Q000097:blood*; D015235:HLA-B Antigens / Q000097:blood*; D006801:Humans; D015994:Incidence; D008297:Male; D011704:Pyelonephritis / Q000175:diagnosis* / Q000453:epidemiology; D012306:Risk; D012426:Russia / Q000453:epidemiology; D014505:Urban Population / Q000706:statistics & numerical data
D015234:HLA-A Antigens; D015235:HLA-B Antigens
Klinicheskoe znachenie antigenov gistosovmestimosti i ikh kombinatsiĭ v diagnostike khronicheskogo pielonefrita.