[Properties of interleukin 8 and its correlation with inflammatory diseases and malignant neoplasia].
Inflammation is a vital consequence of tissue injury caused by various reasons including invasion of foreign particles, infection with microorganisms, autoimmune responses, ischemia-reperfusion injury, and malignant neoplasia. In 1987, a major neutrophil chemotactic and activating factor, now called interleukin 8 (IL-8), was purified and molecularly cloned. In this article, general overview of IL-8 was made describing biochemical structure, regulation of production of IL-8, properties of the receptors for IL-8 and pathophysiological roles of IL-8 in inflammation.
Matsushima
K
K
Dept. of Pharmacology, Kanazawa University, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007239:Infections / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D016209:Interleukin-8 / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology; D008175:Lung Neoplasms / Q000276:immunology; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000276:immunology*; D013274:Stomach Neoplasms / Q000276:immunology; D014407:Tumor Cells, Cultured
D016209:Interleukin-8