title: Evaluation of the effects of rocuronium bromide on haemodynamics and left ventricular function in patients undergoing abdominal aortic surgery.
abstract: In an open study of 26 patients undergoing abdominal aortic surgery, the effects of rocuronium 0.6 mg kg-1 (eight patients) and 0.9 mg kg-1 (nine patients) were compared with those of pancuronium 0.085 mg kg-1 (eight patients) on haemodynamic parameters and transoesophageal echocardiography. The anaesthetic technique was based on a benzodiazepine and low dose fentanyl (6 micrograms kg-1). Pancuronium was associated with a significant increase in mean arterial pressure, end-diastolic area and heart rate, none of which were seen after rocuronium at either dose level.
authors.affiliation: Department of Anaesthesia and Reanimation, Hospital Group Pitié-Salpétrière, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Cornet
authors.forename: M
authors.initials: M
authors.lastname: Abiad
authors.forename: P
authors.initials: P
authors.lastname: Coriat
authors.forename: M
authors.initials: M
authors.lastname: Saada
authors.forename: M L
authors.initials: ML
authors.lastname: Gosgnach
authors.forename: P
authors.initials: P
authors.lastname: Viars
mesh_terms: D000732:Androstanols / Q000494:pharmacology*; D000758:Anesthesia; D001012:Aorta, Abdominal / Q000601:surgery*; D001794:Blood Pressure / Q000187:drug effects; D017548:Echocardiography, Transesophageal; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000494:pharmacology; D000077123:Rocuronium; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D010197:Pancuronium; D000077123:Rocuronium