title: Neurochemical basis of interleukin 2-modified discrimination behaviour.
abstract: We trained one group of rats to discriminate 0.8 mg/kg intraperitoneal (i.p.) d-amphetamine from 1 ml/kg saline and the other to discriminate 0.3 mg/kg i.p. (+/-)-ethylketocyclazocine (EKC) from saline. Recombinant human interleukin 2 (rIL-2), 2 x 10(6) U/kg (or 8.2 nmol/kg) given i.p. 1 h prior to tests, potentiated responses elicited by 0.4 mg/kg d-amphetamine. This potentiation of d-amphetamine responses was suppressed by the opioid receptor antagonist naloxone (1 mg/kg) when administered i.p. together with IL-2. IL-2 (4 x 10(6) U/kg) alone produced EKC-like responses in the EKC-trained animals. The cytokine also potentiated 0.1 mg/kg EKC responses at 2 x 10(6) U/kg, an action that was suppressed by 1 mg/kg naloxone. Data from the present study show that IL-2 exerts the same neurochemical action as that previously observed with IFN-alpha for both d-amphetamine and EKC discrimination in rats.
authors.affiliation: Department of Neuro-Oncology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
authors.forename: B T
authors.initials: BT
authors.lastname: Ho
authors.forename: J G
authors.initials: JG
authors.lastname: Lu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Huo
authors.forename: S H
authors.initials: SH
authors.lastname: Fan
authors.forename: C A
authors.initials: CA
authors.lastname: Meyers
authors.forename: L W
authors.initials: LW
authors.lastname: Tansey
authors.forename: R
authors.initials: R
authors.lastname: Payne
authors.forename: V A
authors.initials: VA
authors.lastname: Levin
mesh_terms: D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects*; D015259:Dopamine Agents / Q000494:pharmacology; D016314:Ethylketocyclazocine / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000187:drug effects
chemical_list: D015259:Dopamine Agents; D007376:Interleukin-2; D011957:Receptors, Opioid; D016314:Ethylketocyclazocine; D003913:Dextroamphetamine