title: The effect of deferoxamine on brain lipid peroxide levels and Na-K ATPase activity following experimental subarachnoid hemorrhage.
abstract: 1. In the present study we have studied the effects of deferoxamine treatment on lipid peroxidation and Na-K ATPase activity after experimental induction of subarachnoid haemorrhage (SAH) in guinea pigs. 2. We assessed the extent of lipid peroxidation by measuring the level of malondialdehyde and Na-K ATPase activity in 3 different groups (sham-operated, SAH, SAH + deferoxamine). 3. There was no significant difference in lipid peroxide content between sham-operated and haemorrhagic animals, but Na-K ATPase activity decreased after SAH. 4. Deferoxamine treatment reduced the malondialdehyde content and induced the recovery of Na-K ATPase activity, exerting a brain protective role against the detrimental effects of the haemorrhage.
authors.affiliation: Department of Biochemistry, Gazi University, Medical Faculty, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Bilgihan
authors.forename: N
authors.initials: N
authors.lastname: Türközkan
authors.forename: A
authors.initials: A
authors.lastname: Aricioğlu
authors.forename: S
authors.initials: S
authors.lastname: Aykol
authors.forename: C
authors.initials: C
authors.lastname: Cevik
authors.forename: M
authors.initials: M
authors.lastname: Göksel
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003676:Deferoxamine / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects*; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D008054:Lipid Peroxides; D000254:Sodium-Potassium-Exchanging ATPase; D003676:Deferoxamine