Odor discrimination deficits in schizophrenia: association with eye movement dysfunction.
Odor discrimination deficits were found in 80% of 20 schizophrenia patients and in none of the 20 age- and sex-matched comparison subjects. Olfactory discrimination was reliably measured in the patients. Twelve patients in this study also had smooth pursuit eye movement (SPEM) qualitatively recorded. The olfactory discrimination scores were highly correlated to SPEM but not to other clinical measures. This correlation suggests a shared neurobiology, possibly involving working memory.
Malaspina
D
D
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY.
Wray
A D
AD
Friedman
J H
JH
Amador
X
X
Yale
S
S
Hasan
A
A
Gorman
J M
JM
Kaufmann
C A
CA
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001767:Blinking; D004585:Electrooculography; D005133:Eye Movements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy; D012903:Smell
D000928:Antidepressive Agents; D014150:Antipsychotic Agents