title: Life-threatening infectious mononucleosis: is it correlated with virus-induced T cell proliferation?
abstract: Infectious mononucleosis is a well-established clinical entity characterized by the proliferation of B lymphocytes that are infected with Epstein-Barr virus (EBV). These lymphocytes give rise to an increase in specifically reacting cytotoxic T cells, which leads to self-limitation of the lympho-proliferative process. We describe the case of a 1-year-old boy who developed life-threatening EBV infection in association with liver failure, depletion of bone marrow, and severe encephalitis. The fact that clinical cure was achieved when acyclovir (50 mg/[kg.d]) and prednisolone (1 mg/[kg.d]) were administered indicates a correlation between antiviral therapy and clinical improvement. Hypogammaglobulinemia--which had not been present at the onset of disease--persisted after clinical recovery. During the acute phase of the illness, the patient's blood lymphocytes were predominantly T cells, most of which contained the EBV genome, as shown by in situ hybridization; some of these cells stained positive for EBV-specific latent membrane protein. Examination of peripheral blood mononuclear cells in vitro revealed an exceedingly high histocompatibility antigen-unrestricted cytotoxicity against the K562 cell line, which is normally not an immunogenic target of cytotoxic cells in patients infected with EBV. This anomalous natural killer cell-like T cell function suggests that EBV infection of T cells might cause auto-aggressive activity, which was probably responsible for the severity of the infection in our patient.
authors.affiliation: Universitätsklinikum Rudolf Virchow, Abteilung Pädiatrie II Hämatologie/Onkologie, Berlin, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Baumgarten
authors.forename: H
authors.initials: H
authors.lastname: Herbst
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: K H
authors.initials: KH
authors.lastname: Seeger
authors.forename: U
authors.initials: U
authors.lastname: Schulte-Overberg
authors.forename: G
authors.initials: G
authors.lastname: Henze
mesh_terms: D002455:Cell Division / Q000276:immunology; D002648:Child; D003602:Cytotoxicity, Immunologic; D004660:Encephalitis / Q000209:etiology; D005814:Genes, Viral / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D007244:Infectious Mononucleosis / Q000097:blood / Q000150:complications*; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000821:virology; D017093:Liver Failure / Q000209:etiology; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology*