Epstein-Barr virus types 1 and 2 have nearly identical LMP-1 transforming genes.
Although variation in the gene encoding the Epstein-Barr virus (EBV) nuclear protein 2 accounts for much of the difference in the transforming activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evaluated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 protein is 93% identical to the prototype type 1 EBV strain B95-8, and this is well within the range of variability previously noted among type 1 EBV LMP-1 genes.
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Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115.
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D000595:Amino Acid Sequence; D001483:Base Sequence; D002051:Burkitt Lymphoma / Q000821:virology; D002472:Cell Transformation, Viral / Q000235:genetics; D005814:Genes, Viral; D014644:Genetic Variation; D004854:Herpesvirus 4, Human / Q000145:classification / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014763:Viral Matrix Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D009856:Oncogene Proteins, Viral; D014763:Viral Matrix Proteins