[Study on the T cell functions induced by anti-CD3mAb in chronic pulmonary heart disease].
We studied the T lymphocyte transformation and IL-2's functions induced by anti-CD3 mAb in 42 cases of CPHD. The T lymphocyte transformation, activity of IL-2 and expression of IL-2R were determined by 3H-TDR incorporation, bioassay and immunoabsorption methods. The results showed that PBL transformation and activity of IL-2 were decreased in the patients of acute exacerbation stage more than those in controls and remission stage (P < 0.05 or P < 0.01); activity of IL-2 in the patients of remission stage was close to that in controls (P > 0.05), but PBL transformation was still less than that in controls (P < 0.01); Expression of IL-1R were increased in the patients more than in controls (P < 0.01). G.I of anti-CD3mAb and PHA stimulating PBL proliferation showed positive correlation (P < 0.01), activity of IL-2 and expression of IL-2R were not correlated (P > 0.05). The results showed that extrinsic IL-2 could enhance PBL proliferations induced by anti-CD3mAb, especially in CPHD patients.
Xu
M Y
MY
Second Teaching Hospital, Norman Bethune University of Medical Sciences, Chang Chun.
Xue
X M
XM
He
G Z
GZ
D000368:Aged; D000911:Antibodies, Monoclonal; D017252:CD3 Complex / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D007376:Interleukin-2; D015375:Receptors, Interleukin-2