title: A comparative study of the safety and efficacy of dysprosium-165 hydroxide macro-aggregate and yttrium-90 silicate colloid in radiation synovectomy--a multicentre double blind clinical trial. Australian Dysprosium Trial Group.
abstract: The aim of our study was to compare the safety and efficacy of a new preparation, Dysprosium-165 Hydroxide Macroaggregate (165Dy) with Yttrium-90 Silicate (90Y) for radiation synovectomy of the knee in patients with RA and OA. A multicentre double blind clinical trial with subjects randomized to receive 165Dy or 90Y was undertaken in Sydney, Melbourne and Perth. Seventy knees of 59 patients were studied, using as clinical end point measurements, pain in the knee on walking, pain in the knee at rest and stiffness in the knee after rest. Cytogenetic damage, knee retention and extra-articular spread of the radionuclide to regional lymph nodes, liver, urine and blood were evaluated. There was no significant difference in clinical response in the two treatment groups for either RA or OA. Chromosomal changes occurred with equal frequency and the knee retention and extra-articular leakage of radiocolloids to regional lymph nodes and liver were comparable in the two groups. For radiation synovectomy of the knee, 165Dy is at least as safe and as effective as 90Y and has the advantage of a short half-life (2.334 h) and hence requires a shorter period of post-injection immobilization and hospitalization.
authors.affiliation: Department of Rheumatology, St. George Hospital, Kogarah, NSW, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Edmonds
authors.forename: R
authors.initials: R
authors.lastname: Smart
authors.forename: R
authors.initials: R
authors.lastname: Laurent
authors.forename: P
authors.initials: P
authors.lastname: Butler
authors.forename: P
authors.initials: P
authors.lastname: Brooks
authors.forename: R
authors.initials: R
authors.lastname: Hoschl
authors.forename: J
authors.initials: J
authors.lastname: Wiseman
authors.forename: S
authors.initials: S
authors.lastname: George
authors.forename: F
authors.initials: F
authors.lastname: Lovegrove
authors.forename: A
authors.initials: A
authors.lastname: Warwick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications / Q000532:radiotherapy*; D004311:Double-Blind Method; D004419:Dysprosium / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000378:metabolism; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000150:complications / Q000532:radiotherapy*; D011829:Radiation Dosage; D011868:Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D012720:Severity of Illness Index; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: D011868:Radioisotopes; D015021:Yttrium Radioisotopes; D004419:Dysprosium