A quantitative electroencephalographic method for xenobiotic screening in the canine model.
A method, using quantitative electroencephalography (qEEG), was developed for screening xenobiotics in conjunction with neurological examinations, for defining toxicodynamic profiles of certain drugs and chemicals in the dog. The standard 10-channel montage was used to evaluate normotonic, auditory, visual, and somatosensory cortical activity. Compressed spectral analysis and Fourier Transformation determined spectral edge frequencies, distribution of the total, fractional and absolute powers of delta, theta, alpha, and beta frequencies as parameters. The alpha 2-agonist, xylazine, was used to detect treatment-related differences, threshold effect levels, and qEEG-target parameters. An increase in theta and alpha activity, and a shift to lower spectral edge frequency were noted. Visual stimulation was the least sensitive test condition in detecting significant changes in measured parameters. Data derived by qEEG may make a reliable contribution to the physiologic interpretation, along with biochemical, clinical, and pathological data collected during a regulatory study.
Jones
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RD
Agriculture Division, Toxicology Miles, Inc., Stilwell, Kansas 66085-9104.
Greufe
N P
NP
D000818:Animals; D004285:Dogs; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D008297:Male; D014116:Toxicology / Q000379:methods*; D015262:Xenobiotics / Q000633:toxicity*; D014991:Xylazine / Q000494:pharmacology
D015262:Xenobiotics; D014991:Xylazine