title: (+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model.
authors.affiliation: Department of Immunology, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: K
authors.initials: K
authors.lastname: Koch
authors.forename: L S
authors.initials: LS
authors.lastname: Melvin
authors.forename: L A
authors.initials: LA
authors.lastname: Reiter
authors.forename: M S
authors.initials: MS
authors.lastname: Biggers
authors.forename: H J
authors.initials: HJ
authors.lastname: Showell
authors.forename: R J
authors.initials: RJ
authors.lastname: Griffiths
authors.forename: E R
authors.initials: ER
authors.lastname: Pettipher
authors.forename: J B
authors.initials: JB
authors.lastname: Cheng
authors.forename: A J
authors.initials: AJ
authors.lastname: Milici
authors.forename: R
authors.initials: R
authors.lastname: Breslow
mesh_terms: D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003094:Collagen; D006168:Guinea Pigs; D006801:Humans; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009504:Neutrophils / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D001578:Benzopyrans; D002264:Carboxylic Acids; D007975:Leukotriene B4; D003094:Collagen; C089698:CP 105696