Study of structure/activity relationships by multivariate statistical analysis in a series of triazaspirodecanediones with CNS activities.
The CNS activities of thirteen triazaspirodecanediones have been compared by multivariate statistical analysis. The response parameters used in this study were spontaneous motor activity, potentiation of pentobarbital effect, anticonvulsant and anxiolytic activities. Pharmacological data were analyzed using two methods: (1) a factorial correspondence analysis; (2) an automatic analysis based first on a hierarchical clustering represented by a dendrogram and second on the minimum spanning tree method. The obtained results allow to imagine the synthesis of more specific compounds.
Doré
J C
JC
Equipe d'Informatique Chimique et Biologique, URA 401 CNRS, Muséum National d'Histoire Naturelle, Paris, France.
Coudert
P
P
Rubat
C
C
Couquelet
J
J
Viel
C
C
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000737:chemistry / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D015999:Multivariate Analysis; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D002491:Central Nervous System Agents; D011743:Pyrimidines; D013141:Spiro Compounds