Induction of PC12 cell death, apoptosis, by a sialoglycopeptide from bovine brain.
The sialoglycopeptide from bovine brain inhibited the growth of PC12 cells in the presence of nerve growth factor. This inhibition was accompanied by DNA fragmentation showing a ladder pattern and changes in cell morphology leading to cytoplasmic condensation. These results suggest that the sialoglycopeptide induces PC12 cell apoptosis in the presence of nerve growth factor.
Kobayashi
Y
Y
Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University, Japan.
Saheki
T
T
Shinozawa
T
T
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D001923:Brain Chemistry; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000032:analysis / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D009414:Nerve Growth Factors / Q000494:pharmacology; D016716:PC12 Cells; D051381:Rats; D012795:Sialoglycoproteins / Q000302:isolation & purification / Q000494:pharmacology*
D004273:DNA, Neoplasm; D009414:Nerve Growth Factors; D012795:Sialoglycoproteins