Comparison of the IgG subclass distribution of anti-thyroid peroxidase antibodies in healthy subjects with that in patients with chronic thyroiditis.
The IgG subclass distribution of anti-thyroid peroxidase (TPO) antibodies in patients with chronic thyroiditis and in healthy subjects has been investigated. Anti-TPO antibodies in sera of patients with chronic thyroiditis were predominantly associated with IgG1, with a lesser contribution by IgG4 and IgG3. In contrast, anti-TPO antibodies of healthy subjects were exclusively associated with IgG4. Since structural differences in IgG subclasses reflect differences in their biological roles, these findings suggest that the role of anti-TPO antibodies in patients may differ from that in healthy subjects.
Kohno
Y
Y
Department of Pediatrics, School of Medicine, Chiba University, Japan.
Kijima
M
M
Yamaguchi
F
F
Saito
K
K
Tsunoo
H
H
Hosoya
T
T
Niimi
H
H
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification* / Q000276:immunology; D007453:Iodide Peroxidase / Q000276:immunology*; D008297:Male; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000276:immunology*
D000906:Antibodies; D007074:Immunoglobulin G; D007453:Iodide Peroxidase