[The dependence of the biological activity of metal complexes on the structural stability of the initial DNA].
The authors have formulated the basic principles of the creation of metallo-constructions with DNA which possess biological activity. Thus, the interaction of metal and DNA during formation of metallo-construction must not destabilize the structure of initial DNA. The studies conducted by the authors prove the hypothesis of the working mechanism of these complexes: pronounced activity against viruses which contain DNA and RNA.
Vaĭnberg
Iu P
IuP
Nosik
D N
DN
Kaplina
E N
EN
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002478:Cells, Cultured; D004247:DNA / Q000737:chemistry* / Q000494:pharmacology; D003864:Depression, Chemical; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D009942:Organometallic Compounds; D004247:DNA
Zavisimost' biologicheskoĭ aktivnosti metallokompleksov ot stabil'nosti struktury iskhodnoĭ DNK.