[Evaluation of a new nitric oxide delivery system during mechanical ventilation].
A new nitric oxide delivery and continuous monitoring system is described. During mechanical ventilation, this new system connected with Siemens Servo 900C ventilator was shown to be able to provide a constant inspired NO concentration (10-100 ppm) using chemiluminescence technique for NO analysis. Gas was analysed at the mixing chamber in front of the ventilator inlet and inspiratory tube connected with the soda-lime carbon-dioxide absorber. Both NO concentrations showed a good correlation (r = 0.99). The actual NO concentration from the NO supply cylinder was 1154 ppm and NO2 concentration was 14 ppm. In mongrel dogs, after 20 minutes of NO inhalation (10-100 ppm), the blood methemoglobin level reached a peak value of 2.2% starting from the pre-inhalation level of 0%. To optimize the safety of the clinical application of NO, its concentration should be measured continuously with chemiluminescence technique.
Noguchi
T
T
Intensive Care Unit, Oita Medical University Hospital.
Miyakawa
H
H
Mori
M
M
Kitano
T
T
Iwasaka
H
H
Oda
S
S
Taniguchi
K
K
Honda
N
N
D000818:Animals; D004285:Dogs; D005069:Evaluation Studies as Topic; D008163:Luminescent Measurements; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods; D009569:Nitric Oxide / Q000008:administration & dosage*; D012121:Respiration, Artificial / Q000592:standards*; D012449:Safety
D009569:Nitric Oxide