title: Decreased platelet adherence of polymer-coated tantalum stents.
abstract: OBJECTIVE
  To compare the acute thrombogenicity of polyurethane-coated stents with that of bare tantalum stents.
  
  
  METHODS
  Thirty stents (15 coated with polyurethane) were balloon expanded in 8-mm x 80-cm sections of polytetrafluoroethylene grafts (six stents per graft). Under sterile conditions, 8- and 10-F vascular sheaths were placed percutaneously in the femoral artery and vein of a 100-lb (45-kg) swine. Platelets were labeled with indium-111 and reinjected for quantitative assay. The stented grafts were connected to the arterial and venous sheaths to create an ex vivo fistula. Each fistula was opened for 5, 10, 30, 60, or 120 minutes, exposing heparinized blood to fully expanded stents. The fistulas were closed, flushed with saline until clear, and fixed with formalin. Stents were explanted, placed in a radionuclide well counter, and scanned with electron microscopy.
  
  
  RESULTS
  Quantitatively, there were considerably fewer platelets on coated versus uncoated stents. At 60 minutes, coated stents averaged 12.93 platelets per 1,000 microns 2 compared with 75.88 platelets per 1,000 microns 2 for bare metallic stents. At 120 minutes, there were 23.22 platelets/1,000 microns 2 versus 102.31 platelets/1,000 microns 2, respectively. Electron microscopy of coated stents demonstrated few scattered platelets at 5, 10, and 30 minutes. There was a uniform layer of platelets at 60 and 120 minutes. Uncoated stents demonstrated random areas of platelet clumping at 5, 10, and 30 minutes. At 60 and 120 minutes, uncoated stents showed extensive layering of platelets and fibrin.
  
  
  CONCLUSIONS
  Polyurethane coating decreases platelet adhesion, relative to bare tantalum, at all time intervals tested.
authors.affiliation: Department of Radiology, Ohio State University Hospitals, Columbus 43210.
authors.forename: A B
authors.initials: AB
authors.lastname: Fontaine
authors.forename: K
authors.initials: K
authors.lastname: Koelling
authors.forename: J
authors.initials: J
authors.lastname: Clay
authors.forename: D G
authors.initials: DG
authors.lastname: Spigos
authors.forename: S
authors.initials: S
authors.lastname: Dos Passos
authors.forename: G
authors.initials: G
authors.lastname: Christoforidis
authors.forename: G
authors.initials: G
authors.lastname: Hinkle
authors.forename: T
authors.initials: T
authors.lastname: Hill
authors.forename: J
authors.initials: J
authors.lastname: Cearlock
authors.forename: R
authors.initials: R
authors.lastname: Pozderac
mesh_terms: D000818:Animals; D005263:Femoral Artery; D005268:Femoral Vein; D007205:Indium Radioisotopes; D008854:Microscopy, Electron; D010973:Platelet Adhesiveness; D011138:Polytetrafluoroethylene; D015607:Stents; D013499:Surface Properties; D013552:Swine; D013635:Tantalum
chemical_list: D007205:Indium Radioisotopes; D013635:Tantalum; D011138:Polytetrafluoroethylene