title: Increased serum levels of C-terminal parathyroid hormone-related protein in different diseases associated with HTLV-1 infection.
abstract: We analyzed the serum levels of C-terminal parathyroid hormone-related protein (C-PTHrP) in asymptomatic carriers of human T lymphotropic virus type 1 (HTLV-1) and patients with three HTLV-1 related diseases; adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 uveitis (HU). Serum C-PTHrP levels were significantly elevated in HTLV-1-infected individuals, irrespective of whether they were symptomatic or asymptomatic, when compared with that of the seronegative controls. In ATL patients, a good correlation was demonstrated between the serum C-PTHrP level and serum calcium or lactic dehydrogenase (LDH) level. Thus the elevated serum C-PTHrP level could be a characteristic marker of HTLV-1 carrier state, and the determination of its level in ATL patients could be useful for the assessment of the prognosis and as one of the tumor markers. The determination of the serum level of C-PTHrP in various stages of the HTLV-1 carrier state would help to understand the mechanism of the development of hypercalcemia in ATL.
authors.affiliation: Blood Transfusion Service, Kumamoto University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Kiyokawa
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Ideta
authors.forename: K
authors.initials: K
authors.lastname: Asayama
authors.forename: M
authors.initials: M
authors.lastname: Mochizuki
authors.forename: A
authors.initials: A
authors.lastname: Blank
authors.forename: K
authors.initials: K
authors.lastname: Takatsuki
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D002118:Calcium / Q000097:blood; D002353:Carrier State / Q000097:blood; D016009:Chi-Square Distribution; D005260:Female; D015490:HTLV-I Infections / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015458:Leukemia, T-Cell / Q000097:blood; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000097:blood; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000378:metabolism*; D011379:Prognosis; D011506:Proteins / Q000378:metabolism*; D011863:Radioimmunoassay; D014605:Uveitis / Q000097:blood / Q000821:virology
chemical_list: D014408:Biomarkers, Tumor; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D011506:Proteins; C077277:parathyroid hormone-related protein (109-138); D007770:L-Lactate Dehydrogenase; D002118:Calcium