title: [Idiopathic thrombocytopenic purpura in 5 members of a family].
abstract: Five cases of idiopathic thrombocytopenic purpura (ITP) appearing on five members of two generations of a family, with autosomal dominant pattern, are presented. The clinico-biologic behaviour of 2 patients (studied and treated by the authors) plus the available data from the 3 others (diagnosed and treated at other hospitals) allowed us to discard any possibility of hereditary non-immunologic thrombocytopenia. The predisposition of ITP patients and their relatives to present clinico-biological features of autoimmune diseases is commented as a possible explanation for the rare forms of familial ITP.
authors.affiliation: Servicio de Hematología y Hemoterapia, Fundación Jiménez Díaz Facultad de Medicina de la Universidad Autónoma de Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Sánchez Fayos
authors.forename: E
authors.initials: E
authors.lastname: Olavarría
authors.forename: A
authors.initials: A
authors.lastname: Román
authors.forename: A
authors.initials: A
authors.lastname: Cabello
authors.forename: C
authors.initials: C
authors.lastname: Soto
authors.forename: C
authors.initials: C
authors.lastname: Paniagua
mesh_terms: D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000235:genetics*; D002675:Child, Preschool; D005260:Female; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*
vernacular_title: Púrpura trombocitopénica idiopática en cinco miembros de una familia.