title: Poly(alkylcyanoacrylate) nanocapsules: physicochemical characterization and mechanism of formation.
abstract: Nanocapsules of poly(isobutylcyanoacrylate) and poly(isohexylcyanoacrylate) were prepared by addition of the monomer to an organic phase and subsequent mixing of the organic phase to an aqueous phase containing poloxamer 188, 238 or 407. Gel permeation chromatography indicated that in contrast to literature reports, polymerization occurred in the organic phase and nanocapsules were obtained by interfacial precipitation of the polymer without any significant change of the molecular weight. Addition of SO2 to the organic phase before the introduction of the monomer allowed preparation of nanocapsules with a lower molecular weight. Nanospheres were prepared in a similar way albeit using an organic phase that was completely miscible within the aqueous phase so that solid spheres were obtained. Density gradient centrifugation revealed that nanocapsules had a density intermediate between nanospheres and an emulsion prepared in the same way without addition of monomer to the organic phase. Further, the process used to prepare nanocapsules had a high yield since no oil droplets or nanospheres were obtained by this process. Zeta potential of the nanocapsules and spheres was found to be related to the molecular weight of the polymer: values as high as approximately -42 mV were obtained for low molecular weight nanocapsules (MW approximately 1000) compared to approximately -10mV for the emulsion and the high molecular weight nanocapsules (MW approximately 100,000). Surface charge of the nanocapsules and molecular weight of their polymeric wall conditioned the adsorption capacity of poloxamers. Moreover, the highest adsorption was measured with the most hydrophobic poloxamer. These observations agree with previous work conducted on hydrophobic surfaces.
authors.affiliation: Glaxo Canada Inc., Mississauga, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Chouinard
authors.forename: S
authors.initials: S
authors.lastname: Buczkowski
authors.forename: V
authors.initials: V
authors.lastname: Lenaerts
mesh_terms: D000327:Adsorption; D002214:Capsules; D002499:Centrifugation, Density Gradient; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002850:Chromatography, Gel; D003487:Cyanoacrylates / Q000737:chemistry*; D004563:Electrochemistry; D004655:Emulsions; D008970:Molecular Weight; D010772:Phosphotungstic Acid / Q000737:chemistry; D011060:Poloxalene
chemical_list: D002214:Capsules; D003487:Cyanoacrylates; D004655:Emulsions; D010772:Phosphotungstic Acid; D011060:Poloxalene