[Differential diagnostic aspects of lethal midline granulomas (granuloma gangraenescens].
The lethal midline granuloma and limited Wegener's granulomatosis show clinical similarity, although they are of different etiology. The following case of a 53-year-old woman shows how difficult it is to establish the precise diagnosis of lethal midline granuloma. The diagnosis depends on the pathological finding of a lymphoma. The lymphoma can be differentiated in a T- or a B-cell lymphoma by immunostaining. However, the diagnostic yield of biopsies from the nose is not perfect. It would be, therefore, important to find other diagnostic criteria. The presence of the c-ANCA is a helpful tool, but in the case of limited Wegener's granulomatosis, it has a sensitivity of 50%. The prognosis of the lethal midline granuloma is poor even if an adequate radiation therapy is instituted.
Rothacher
U M
UM
Abteilung Rheumatologie, Medizinische Universitätsklinik Freiburg.
Rump
J A
JA
Herbst
E W
EW
Blum
U
U
Maier
W
W
Peter
H H
HH
D003937:Diagnosis, Differential; D005260:Female; D006103:Granuloma, Lethal Midline / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
Differentialdiagnostische Aspekte des letalen Midline-Granuloms (Granuloma gangraenescens).