Fungicin M4: a narrow spectrum peptide antibiotic from Bacillus licheniformis M-4.
The strain Bacillus licheniformis M-4 produces a 3.4 kDa hydrophilic peptide with antifungal activity, named fungicin M4. Analysis of the purified peptide shows that it contains the amino acids Glu (8), Arg (5), Pro (4), Tyr (8), Val (3), Met (2) and Orn (4). Its inhibitory spectrum is restricted to Microsporum canis CECT 2797, Mucor mucedo CECT 2653, Mucor plumbeus CCM 443, Sporothrix schenckii CECT 2799, Bacillus megaterium and Corynebacterium glutamicum CECT 78. Fungicin M4 exerts biocidal activity on liquid cultures of Sporothrix schenckii CECT 2799.
Lebbadi
M
M
Department of Microbiology, Faculty of Sciences, University of Granada, Spain.
Gálvez
A
A
Maqueda
M
M
Martínez-Bueno
M
M
Valdivia
E
E
D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010455:Peptides
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010455:Peptides