Elevated plasma soluble interleukin 2 receptor level correlates with defective natural killer and CD8+ T-cells in myelodysplastic syndromes.
The plasma soluble interleukin 2 receptor (sIL-2R) level and its relationships with haematologic and immunologic data were examined in 40 patients with myelodysplastic syndromes (MDS). The plasma sIL-2R level was significantly higher in the high-risk MDS group (refractory anaemia with excess blasts (RAEB), RAEB in transformation and chronic myelomonocytic leukaemia) than in the low-risk MDS group (refractory anaemia (RA) and RA with ringed sideroblasts) or in normal subjects, although there was considerable variation in the plasma sIL-2R level within each MDS group. The plasma sIL-2R level correlated positively with the bone marrow cellularity and bone marrow blast mass, but not with the absolute number of CD25+ lymphocytes. This may support the idea that plasma sIL-2R is derived from malignant MDS cells in the bone marrow. The plasma sIL-2R level correlated negatively with the absolute numbers of the CD8+, CD3-CD16+, and CD3-CD56+ cell populations in freshly isolated lymphocytes, the percentage of CD3-CD56+ cells in lymphokine (interleukin 2)-activated killer (LAK) cells, and the cytotoxicity of LAK cells. We conclude that MDS patients having a high plasma sIL-2R level often have a defect in natural killer and CD8+ T-cells.
Yokose
N
N
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Ogata
K
K
Ito
T
T
An
E
E
Tamura
H
H
Dan
K
K
Hamaguchi
H
H
Sakamaki
H
H
Onozawa
Y
Y
Nomura
T
T
D000328:Adult; D000368:Aged; D000753:Anemia, Refractory / Q000097:blood / Q000276:immunology*; D000754:Anemia, Refractory, with Excess of Blasts / Q000097:blood / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D015477:Leukemia, Myelomonocytic, Chronic / Q000097:blood / Q000276:immunology*; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000378:metabolism*
D015375:Receptors, Interleukin-2