Effects of chronic ethanol consumption on gestation and lactation in rats.
Chronic consumption of ethanol during pregnancy and lactation may lead to abnormalities in the fetus or infant. A group of female Wistar rats was submitted to ethanol treatment over a period of a month. A pair-fed control group received sucrose solution isocaloric to ethanol and the control group received water "ad libitum." Afterward, the females were mated with males over a period of 20 days. At birth, each litter was maximized to eight pups and the remaining ones were decapitated to remove the fetal blood and brains. No significant difference was observed in fetal body and brain weight at birth. During lactation the ethanol and pair-fed groups gained less weight than the control group. After weaning, their weight became similar. Fetal blood glucose levels were decreased in the ethanol-treated group. One hundred percent of the pair-fed and control females delivered live fetuses at term and all survived; only 40% of the females in the ethanol group delivered, and one pup did not survive. Chronic ethanol treatment pointed to a possible reduction in the fertility. It seems likely that the change in body weight of ethanol-fed dams was caused by undernutrition.
Maldaner
F H
FH
Universidade Federal do Rio Grande do Sul, Brasil.
Durgante
L P
LP
Murussi
M
M
Xavier
M K
MK
Dalmaz
C
C
Ferreira
M B
MB
D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects* / Q000493:pharmacokinetics; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000097:blood / Q000209:etiology*; D007774:Lactation / Q000187:drug effects* / Q000502:physiology; D008098:Litter Size / Q000187:drug effects / Q000502:physiology; D008297:Male; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D000431:Ethanol