Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum.
Rifampicin was inactivated by Nocardia otitidiscaviarum to yield two products designated RIP-3 and RIP-4. The full structures of RIP-3 and RIP-4 were determined to be 21-(O-phosphoryl) rifampicin and 3-formyl-21-(O-phosphoryl) rifamycin SV, respectively, but neither product had any antimicrobial activity.
Yazawa
K
K
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Mikami
Y
Y
Maeda
A
A
Morisaki
N
N
Iwasaki
S
S
D001711:Biotransformation; D003352:Corynebacterium / Q000187:drug effects; D004352:Drug Resistance, Microbial; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects / Q000378:metabolism*; D010766:Phosphorylation; D012240:Rhodococcus / Q000187:drug effects; D012293:Rifampin / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
C084371:21-(O-phosphoryl)rifampicin; C084372:3-formyl-21-(O-phosphoryl)rifamycin SV; D012293:Rifampin