Regulation of growth hormone secretion by the growth hormone releasing hexapeptide (GHRP-6).
Growth hormone (GH) secretion is regulated by a complex system of central and peripheral signals. Recently, a new GH-releasing hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically releases GH has been studied. In the present work the mechanism of action of GHRP-6 has been addressed in experimental animal models as well as in obese subjects. GHRP-6 releases GH independently of the hypothalamic factors GHRH and somatostatin and is a powerful GH releaser in obesity.
Micic
D
D
Institute of Endocrinology, Belgrade University, Yugoslavia.
Mallo
F
F
Peino
R
R
Cordido
F
F
Leal-Cerro
A
A
Garcia-Mayor
R V
RV
Casanueva
F F
FF
D000818:Animals; D004967:Estrogens / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D009765:Obesity / Q000503:physiopathology; D009842:Oligopeptides / Q000502:physiology*
D004967:Estrogens; D005938:Glucocorticoids; D009842:Oligopeptides; C041048:growth hormone releasing hexapeptide; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone