title: n-3 fatty acid deficiency increases brain protein synthesis in the free-moving adult rat.
abstract: The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control animals. Biochemical analysis confirmed the increase in overall rate of protein synthesis in brain as a whole.
authors.affiliation: CERMEP, Hôpital Neurologique, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Giaume
authors.forename: N
authors.initials: N
authors.lastname: Gay
authors.forename: V
authors.initials: V
authors.lastname: Baubet
authors.forename: A
authors.initials: A
authors.lastname: Gharib
authors.forename: G
authors.initials: G
authors.lastname: Durand
authors.forename: P
authors.initials: P
authors.lastname: Bobillier
authors.forename: N
authors.initials: N
authors.lastname: Sarda
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D003677:Deficiency Diseases / Q000378:metabolism / Q000503:physiopathology; D015525:Fatty Acids, Omega-3 / Q000378:metabolism* / Q000502:physiology; D005260:Female; D008715:Methionine / Q000378:metabolism; D009068:Movement / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013462:Sulfur Radioisotopes
chemical_list: D015525:Fatty Acids, Omega-3; D011506:Proteins; D013462:Sulfur Radioisotopes; D008715:Methionine