title: Medulloblastoma in adulthood: prognostic factors influencing survival and recurrence.
abstract: Thirty adult patients presenting with medulloblastoma between 1974 and 1991 were studied and treated at Puerta de Hierro Clinic. After diagnosis, all patients were treated by surgery followed by radiotherapy and eight of them received adjuvant chemotherapy. We have studied the influence of some factors such as age, sex, location of tumour in the cerebellum, amount of surgical resection and histological variants on survival and recurrence of the disease. Only the histological type has a statistically significant influence on survival and recurrence: we have found that patients presenting classic medulloblastoma have a long survival and a long relapse-free interval.
authors.affiliation: Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
authors.forename: M P
authors.initials: MP
authors.lastname: Aragonés
authors.forename: R
authors.initials: R
authors.lastname: Magallón
authors.forename: C
authors.initials: C
authors.lastname: Piqueras
authors.forename: L
authors.initials: L
authors.lastname: Ley
authors.forename: J
authors.initials: J
authors.lastname: Vaquero
authors.forename: G
authors.initials: G
authors.lastname: Bravo
mesh_terms: D000293:Adolescent; D000328:Adult; D002528:Cerebellar Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002557:Cerebrospinal Fluid Shunts; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008527:Medulloblastoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate