title: [Genetics of colorectal cancer. Practical value].
abstract: The age and family history of colorectal cancer are the main risk factors for colorectal cancer. Taking into account the family history of colorectal cancer, the first degree relatives of a patient have a risk that increases to 2 or 3 as compared to general population. The genetic basis for colorectal cancer was recently investigated by complex segregation analysis. They favoured a dominant gene with a gene frequency of 6 :1000. These analyses represent the first step in order to localize the susceptibility genes that are responsible for the familial aggregation of colorectal cancer.
authors.affiliation: Laboratoire de génétique des tumeurs, institut Curie, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Laurent-Puig
mesh_terms: D000367:Age Factors; D015984:Causality; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005799:Genes, Dominant; D006801:Humans; D012307:Risk Factors
vernacular_title: La génétique du cancer colorectal. Intérêt pratique.