title: Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
abstract: Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.
authors.affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.
authors.forename: H
authors.initials: H
authors.lastname: Fu
authors.forename: K
authors.initials: K
authors.lastname: Xia
authors.forename: D C
authors.initials: DC
authors.lastname: Pallas
authors.forename: C
authors.initials: C
authors.lastname: Cui
authors.forename: K
authors.initials: K
authors.lastname: Conroy
authors.forename: R P
authors.initials: RP
authors.lastname: Narsimhan
authors.forename: H
authors.initials: H
authors.lastname: Mamon
authors.forename: R J
authors.initials: RJ
authors.lastname: Collier
authors.forename: T M
authors.initials: TM
authors.lastname: Roberts
mesh_terms: D048948:14-3-3 Proteins; D016475:3T3 Cells; D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D004789:Enzyme Activation; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010766:Phosphorylation; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D019908:Proto-Oncogene Proteins c-raf; D015398:Signal Transduction; D018411:Spodoptera; D014446:Tyrosine 3-Monooxygenase; D016335:Zinc Fingers
chemical_list: D048948:14-3-3 Proteins; D009419:Nerve Tissue Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D014446:Tyrosine 3-Monooxygenase; D011065:Poly(ADP-ribose) Polymerases; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf