Species differences in changes of heart monoamine oxidase activities with age.
It has previously been established that MAO-A activity markedly increases (about 600%) with age in the rat heart. The aim of the present study was to examine the effect of age on the activity of MAO-A and -B in the mouse heart. In contrast to the rat heart, beta-phenylethylamine is deaminated by MAO-B in the mouse heart. Heart MAO-B activity was found to significantly increase (about 70%) with age in both male and female mice, whereas MAO-A activity remained unchanged. Compared to age-matched rats, serotonin-deaminating activity was about 35 times and 204 times lower in young and old mice, respectively.
Strolin Benedetti
M
M
Farmitalia Carlo Erba, Research and Development-Erbamont Group, Milan, Italy.
Thomassin
J
J
Tocchetti
P
P
Dostert
P
P
Kettler
R
R
Da Prada
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003641:Deamination; D005260:Female; D008297:Male; D051379:Mice / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D010084:Oxidation-Reduction; D010627:Phenethylamines / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D012727:Sex Characteristics; D013045:Species Specificity
D010627:Phenethylamines; C029261:phenethylamine; D012701:Serotonin; D008995:Monoamine Oxidase