Age, environmental factors and drug metabolism.
Both ageing and the environment have a significant impact on xenobiotic metabolism. Furthermore, there is some evidence from in vivo studies that the elderly respond to environmental changes to a lesser degree than younger individuals. This article reviews the available evidence and concentrates on possible underlying mechanisms.
O'Mahony
M S
MS
University Department of Geriatric Medicine, Cardiff Royal Infirmary, U.K.
Woodhouse
K W
KW
D000375:Aging / Q000378:metabolism*; D000818:Animals; D004777:Environment; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations