Warfarin resistance due to malabsorption.
A female patient developed warfarin resistance after 2 years of satisfactory therapy. Only a third of orally administered warfarin was absorbed, the clearance of warfarin was normal. The patient was also resistant for dicoumarol, while phenandione had satisfactory effect on the prothrombin time (PT).
Talstad
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Haukeland University Hospital, Bergen, Norway.
Gamst
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ON
D000368:Aged; D004351:Drug Resistance / Q000502:physiology; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D014859:Warfarin / Q000493:pharmacokinetics*
D014859:Warfarin