RU486 combined with PGE1 analog in voluntary termination of early pregnancy--a comparison of recent findings with gemeprost or misoprostol.
This paper addresses itself to comparing the findings from more recent studies on the termination of early pregnancy in women by a medical method involving a combination of RU486 and gemeprost (a PGE1 analog which is administered as a vaginal pessary) or RU486 and misoprostol (an orally active PGE1 analog). In particular, the data in these studies relating to (i) time to expulsion of the conceptus and (ii) duration of vaginal bleeding have been compared by statistical tests. It was shown that the shortest time to expulsion after PGE1 was when gemeprost was administered at 48hr following RU486. There was also an increased duration of bleeding with this treatment. These findings are discussed in relation to women's attitudes toward abortion methods especially in regard to preferring a decreased induction-abortion interval and a duration of bleeding of less than 14 days.
Peplow
P V
PV
Department of Anatomy, University of Otago, Dunedin, New Zealand.
D000028:Abortion, Induced; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D012189:Retrospective Studies; D013997:Time Factors; D014592:Uterine Hemorrhage
D016595:Misoprostol; D015735:Mifepristone; C021182:gemeprost; D000527:Alprostadil