[Dynamics of fluoroquinolone agents in tear fluid--a comparison of the dynamic in tears of human and rabbit eyes].
We compared the dynamics of fluoroquinolones administered either systemically or locally, in the tears of human and rabbit eyes. The concentrations of locally administered ofloxacin (OFLX) in the human and rabbit tear fluid were similar. However, there was a difference between the norfloxacin (NFLX) concentrations in human and rabbit tear fluid measured after instillation. The NFLX concentrations in the tear fluid were significantly higher than the OFLX concentrations and they were retained longer with oral administration. On the other hand, the drug dynamics depended on the concentrations of the drug in the serum, and were better in the rabbit eyes than in the human eyes. Knowing the correlation of drug dynamics in rabbit and human eyes may supply useful information about drug dynamics in human eyes, and may be a useful index for clinical treatment.
Fukuda
M
M
Department of Ophthalmology, Kanazawa Medical University, Japan.
Murano
H
H
Sasaki
K
K
D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000818:Animals; D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D013666:Tears / Q000378:metabolism*
D015242:Ofloxacin; D009643:Norfloxacin