Neutrophil leukotriene generation and pulmonary dysfunction after abdominal aortic aneurysm repair.
BACKGROUND
The purpose of this study was to assess the role of polymorphonuclear neutrophil (PMN)-generated leukotriene B4 (LTB4) as an etiologic agent in the pulmonary dysfunction seen after operation in patients undergoing abdominal aortic aneurysm repair.


METHODS
Blood was analyzed in 10 consecutive patients undergoing elective infrarenal abdominal aortic aneurysm repair for plasma thromboxane B2, lactoferrin, C3a, and PMN-generated LTB4.


RESULTS
There was a close linear correlation (r = 0.88; p < 0.001) between aortic clamp time and PMN LTB4 production. Conversely, aortic clamp time and the ratio of arterial oxygen pressure to fraction of inspired oxygen, a measure of pulmonary function, were inversely related (r = -0.80; p < 0.008). PMNs from patients with long aortic cross-clamp times generated three times more LTB4 than those patients with short cross-clamp times (194 +/- 29.6 vs 64.9 +/- 9.7 ng per 5 x 10(6) PMN; p < 0.05). Similarly, the pressure/inspired oxygen ratio was significantly lower on admission to the intensive care unit in patients with long cross-clamp times as compared with patients with short cross-clamp times (237 +/- 14 vs 342 +/- 5; p < 0.005). In addition, patients with long cross-clamp times remained intubated longer than patients with short times (1.6 +/- 0.2 vs 0.6 +/- 0.4 days; p < 0.05).


CONCLUSIONS
These data suggest a causal role for LTB4 in the generation of pulmonary dysfunction in patients undergoing abdominal aortic aneurysm repair, similar to what has been shown in animal models.
Gadaleta
D
D
Department of Surgery, Cornell University Medical Center, New York, NY 10021.
Fantini
G A
GA
Silane
M F
MF
Davis
J M
JM
D000368:Aged; D001011:Aorta; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D003250:Constriction; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology; D015427:Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors
D007975:Leukotriene B4