title: Indonesian medicinal plants. VIII. Chemical structures of three new triterpenoids, bruceajavanin A, dihydrobruceajavanin A, and bruceajavanin B, and a new alkaloidal glycoside, bruceacanthinoside, from the stems of Brucea javanica (Simaroubaceae).
abstract: Three new apotirucallane-type triterpenoids named bruceajavanin A (1) dihydrobruceajavanin A (2) and bruceajavanin B (3), and a novel beta-carboline alkaloidal glycoside named bruceacanthinoside (4) were isolated from the stems of Brucea javanica (Simaroubaceae), a traditional medicine used to treat malaria in the Bengkulu area, Sumatra, Indonesia. Their chemical structures have been elucidated on the bases of their chemical and physicochemical properties. Bruceajavanin A (1), dihydrobruceajavanin A (2) and bruceacanthinoside (4) were shown to inhibit growth of the cultured malarial parasite Plasmodium falciparum K1 of a chloroquine-resistant strain.
authors.affiliation: Faculty of Pharmaceutical Sciences, Osaka University, Suita, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kitagawa
authors.forename: T
authors.initials: T
authors.lastname: Mahmud
authors.forename: P
authors.initials: P
authors.lastname: Simanjuntak
authors.forename: K
authors.initials: K
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Uji
authors.forename: H
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C089884:1,2-dihydrobruceajavanin A; D000962:Antimalarials; D014315:Triterpenes; C089882:bruceajavanin A; C089883:bruceajavanin B