Obstetrical and gynecological complications in fragile X carriers: a multicenter study.
We have conducted a multicenter obstetrical and gynecological survey of women in fragile X families. Included in the study were 131 gene carriers (39 with a full mutation and 92 with a premutation) and 109 noncarriers. Analysis indicated that higher numbers of fragile X gene carriers reported having irregular menses and other gynecological complications. As a group they also experienced cessation of menses prior to age 40 years at a significantly higher rate. The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia.
Schwartz
C E
CE
Greenwood Genetic Center, South Carolina 29646.
Dean
J
J
Howard-Peebles
P N
PN
Bugge
M
M
Mikkelsen
M
M
Tommerup
N
N
Hull
C
C
Hagerman
R
R
Holden
J J
JJ
Stevenson
R E
RE
D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D003120:Colorado; D004252:DNA Mutational Analysis; D003718:Denmark; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008594:Menopause, Premature / Q000235:genetics*; D008599:Menstruation Disturbances / Q000209:etiology* / Q000235:genetics; D009154:Mutation; D009864:Ontario; D009867:Oogonia / Q000502:physiology; D011247:Pregnancy; D012091:Repetitive Sequences, Nucleic Acid; D018570:Risk Assessment; D013022:South Carolina; D014768:Virginia