[Effects of NIK-247 on the spontaneous EEG of normal and nucleus basalis magnocellularis lesioned rats].
Effects of oral administration of NIK-247 (9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta-[b] quinoline monohydrochloride monohydrate) and THA (9-amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate) on the EEG of normal and nucleus basalis magnocellularis (NBM) lesioned rats were examined. NIK-247 at 1 mg/kg and 3 mg/kg did not show any effects on the EEG of normal rats, but NIK-247 at 10 mg/kg significantly lowered the total power of the cortical EEG in normal rats. THA at 3 mg/kg and 10 mg/kg also decreased the total power of cortical EEG in normal rats. In the NBM-lesioned rats, decreases of delta wave activity as well as the total power of cortical EEG were observed with both NIK-247 and THA at 3 mg/kg, respectively. The arousal effects of these two drugs were comparable to the effect of physostigmine, suggesting the central cholinergic effects of both NIK-247 and THA.
Kojima
J
J
Omiya Research Laboratory, Nikken Chemical Co., Ltd., Saitama, Japan.
Yamana
K
K
D000284:Administration, Oral; D000634:Aminoquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002800:Cholinesterase Inhibitors; D004569:Electroencephalography / Q000187:drug effects*; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013377:Substantia Innominata / Q000503:physiopathology*; D013619:Tacrine / Q000494:pharmacology
D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D011619:Psychotropic Drugs; D013619:Tacrine; D010830:Physostigmine; C049860:amiridine