Cirrhosis in patients with rheumatoid arthritis receiving low dose methotrexate.
We describe three patients with RA who developed cirrhosis while taking low dose methotrexate (MTX). This report includes a review of the risk factors for cirrhosis occurring in association with MTX. Two of these patients were part of a prospective study to quantify changes in pericellular and total collagen in 76 patients with RA receiving low dose pulse MTX, giving a point prevalence of cirrhosis of 2.63%.
Chandran
G
G
Department of Medicine, Repatriation General Hospital, Daw Park, South Australia.
Ahern
M J
MJ
Hall
P D
PD
Geddes
R
R
Smith
M D
MD
Hill
W
W
Harley
J H
JH
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*
D008727:Methotrexate