Relationship between calcium permeability and rectification properties of AMPA receptors in cultured rat hippocampal neurons.
Cultured rat hippocampal neurons were classified into three groups on the basis of the functional properties of their AMPA-subtype glutamate receptors. The type I neuron had AMPA receptors with an outwardly rectifying I-V relation and little permeability to Ca2+ whereas the AMPA receptors in the type II neuron were characterized by marked inward rectification and high Ca2+ permeability. In the third type of neuron, the responses of AMPA receptors exhibited intermediate properties in both I-V relation and Ca2+ permeability. We suggest that these intermediate properties in the third type of neuron reflect the coexistence of Ca(2+)-permeant and Ca(2+)-impermeant AMPA receptors.
Iino
M
M
Department of Physiology, School of Medicine, Gunma University, Japan.
Mochizuki
S
S
Ozawa
S
S
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D018091:Receptors, AMPA / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
D018091:Receptors, AMPA; D007608:Kainic Acid; D002118:Calcium