title: [gamma-heavy chain production as an epiphenomenon in non-Hodgkin's lymphoma].
abstract: A 46-year-old woman was found to have localized lymphoplasmocytic lymphoma (low-malignancy non-Hodgkin lymphoma). Repeated recurrences required various chemotherapy courses with different drugs. Gamma heavy chains in serum and urine, as well as in blast cells in bone marrow, were first found 3 years later as part of a follow-up examination. When the lymphoplasmocytic lymphoma subsequently changed into a highly malignant disseminated large-cell lymphoma, the monoclonal gamma heavy chain-producing components no longer occurred. During continuing treatment and presumably selection of different cell clones the now terminal chemotherapy-resistant lymphoma again produced biclonal IgG heavy chains. The gamma heavy chain production added little to the histomorphological characterization of the underlying lymphoma, as well as its treatment and prognosis.
authors.affiliation: Departement Innere Medizin, Kantonsspital, Basel.
authors.forename: H B
authors.initials: HB
authors.lastname: Orth
authors.forename: N
authors.initials: N
authors.lastname: Hurwitz
authors.forename: A
authors.initials: A
authors.lastname: Lohri
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
mesh_terms: D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006362:Heavy Chain Disease / Q000175:diagnosis; D006801:Humans; D007142:Immunoglobulin gamma-Chains / Q000032:analysis / Q000096:biosynthesis*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D008207:Lymphatic Metastasis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction
chemical_list: D007142:Immunoglobulin gamma-Chains
vernacular_title: gamma-Schwerketten-Produktion als Epiphänomen bei Non-Hodgkin-Lymphom.