title: Neurological illness following treatment with fludarabine.
abstract: Fludarabine is a comparatively new drug for the treatment of low-grade lymphoid malignancy. This report describes five cases of unusual neurological illnesses occurring after treatment with fludarabine. These suggest that caution should be exercised in patients receiving fludarabine who develop neurological abnormalities, with prompt investigation and if necessary cessation of the drug.
authors.affiliation: Department of Medical Oncology, St Bartholomew's Hospital, London, UK.
authors.forename: P W
authors.initials: PW
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Fearnley
authors.forename: P
authors.initials: P
authors.lastname: Domizio
authors.forename: J
authors.initials: J
authors.lastname: Goldin
authors.forename: K
authors.initials: K
authors.lastname: Nagendran
authors.forename: J
authors.initials: J
authors.lastname: Gawler
authors.forename: A Z
authors.initials: AZ
authors.lastname: Rohatiner
authors.forename: T A
authors.initials: TA
authors.lastname: Lister
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D014740:Vidarabine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014740:Vidarabine; C024352:fludarabine