title: Prostaglandins, thromboxanes, leukotrienes, and cytochrome P-450 metabolites of arachidonic acid.
abstract: Arachidonic acid is metabolized via three major enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P-450. The cyclooxygenase pathway gives rise to the prostaglandins and thromboxane A2. The lipoxygenase pathway produces the leukotrienes and 5-, 12-, and 15-hydroxyeicosatetraenoic acids. The cytochrome P-450 pathway metabolites are oxygenated metabolites of arachidonic acid. Synthesis of several of the cyclooxygenase and lipoxygenase metabolites are increased in circulatory shock. A potential role for several of these compounds in the pathophysiologic sequelae of endotoxic and septic shock has been implied from a combination of animal and human studies. There are no studies that have explored a potential role for cytochrome P-450 metabolites in the pathogenesis of circulatory shock.
authors.affiliation: Department of Physiology, Medical University of South Carolina, Charleston.
authors.forename: J A
authors.initials: JA
authors.lastname: Cook
authors.forename: J
authors.initials: J
authors.lastname: Geisel
authors.forename: P V
authors.initials: PV
authors.lastname: Halushka
authors.forename: H D
authors.initials: HD
authors.lastname: Reines
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism*
chemical_list: D015289:Leukotrienes; D011453:Prostaglandins; D013931:Thromboxanes; D016718:Arachidonic Acid; D003577:Cytochrome P-450 Enzyme System