title: Properties and regulation of the renal vacuolar H(+)-ATPase and H(+)-K(+)-ATPase.
abstract: Two proton-transporting ATPases participate in active proton transport in the nephron: the electrogenic vacuolar H(+)-ATPase and the electroneutral H(+)-K(+)-ATPase. The vacuolar H(+)-ATPase participates in proximal and distal hydrogen ion secretion related to acid-base homeostasis. The H(+)-K(+)-ATPase is located exclusively in the distal nephron, and its primary role may be in active potassium reabsorption. The properties, distribution, and regulation of these two enzymes are discussed.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: S L
authors.initials: SL
authors.lastname: Gluck
authors.forename: R D
authors.initials: RD
authors.lastname: Nelson
authors.forename: B S
authors.initials: BS
authors.lastname: Lee
mesh_terms: D000818:Animals; D005033:Ethylmaleimide / Q000494:pharmacology; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D014018:Tissue Distribution; D014617:Vacuoles / Q000201:enzymology
chemical_list: D017506:H(+)-K(+)-Exchanging ATPase; D006180:Proton-Translocating ATPases; D005033:Ethylmaleimide