title: [Pain in humans: experimental facts and hypotheses].
abstract: The description of painful phenomena in humans has to take into account its different components: sensory component (relevant to nociception), affective and emotional components. Nociceptor's (physiology is best understood with electrophysiological and neurochemical methods allowing a clear description of hyperalgesia, with its peripheral and spinal mechanisms. A functional model is partly available to explain allodynia, spontaneous burning pain and lightning pain, the three main consequences following deafferentation. At the thalamo-cortical level, one can describe nociceptive pathways and other pathways or neuronal networks involved in the affective and emotional components of pain.
authors.affiliation: Département de neurosciences médicales, Centre hospitalier universitaire Henri-Mondor, Créteil.
authors.forename: P
authors.initials: P
authors.lastname: Cesaro
mesh_terms: D006801:Humans; D008959:Models, Neurological; D009422:Nervous System Diseases / Q000503:physiopathology; D009424:Nervous System Physiological Phenomena; D009484:Neuropsychology; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology* / Q000523:psychology
vernacular_title: La douleur chez l'homme: faits expérimentaux et hypothèses.