title: Evidence for an abnormal postprandial response to a high-fat meal in women predisposed to obesity.
abstract: The present study was undertaken to investigate fat metabolism after a high-fat meal [50 energy percent (E%) fat] in formerly obese subjects with a familial history of obesity. Twelve normal-weight postobese women (PO) and 12 closely matched controls were given the test meal after a 2-day carbohydrate-rich weight-maintenance diet (58 E% carbohydrate). Whereas the thermic effect of the meals was similar in the two groups, postprandial fat oxidation was 2.5 times more suppressed in PO compared with controls (P < 0.05). A similarly enhanced suppression of arterialized plasma concentrations of nonesterified fatty acids was seen postprandially in PO (P < 0.05), possibly due to a more marked suppression of epinephrine and a reduced glucagon response in PO than in controls. Moreover, the postprandial plasma triglyceride response was attenuated and only amounted to 43% of that in controls (P < 0.05). This may be explained by a more pronounced increase in gastric inhibitory polypeptide in PO, giving rise to a higher adipose tissue lipoprotein lipase activity. No other differences were found in plasma substrates and hormones or in subjective appetite scores. In conclusion, a metabolic and hormonal pattern favoring lipid storage was observed in postobese subjects after a high-fat meal.
authors.affiliation: Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Raben
authors.forename: H B
authors.initials: HB
authors.lastname: Andersen
authors.forename: N J
authors.initials: NJ
authors.lastname: Christensen
authors.forename: J
authors.initials: J
authors.lastname: Madsen
authors.forename: J J
authors.initials: JJ
authors.lastname: Holst
authors.forename: A
authors.initials: A
authors.lastname: Astrup
mesh_terms: D000328:Adult; D004041:Dietary Fats / Q000494:pharmacology*; D004198:Disease Susceptibility; D004435:Eating; D004734:Energy Metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006728:Hormones / Q000097:blood; D006801:Humans; D009765:Obesity / Q000503:physiopathology*; D010084:Oxidation-Reduction; D012528:Satiety Response; D013649:Taste; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D006728:Hormones; D014280:Triglycerides; D005990:Glycerol