title: Cobalt-related asthma: clinical and immunological aspects.
abstract: Several clinical and experimental findings point to cobalt as the only sensitizer and causal agent of hard metal asthma. The clinical features have been clearly defined by bronchial provocation tests, with a prevalence of late phase responses. Epidemiology is still insufficient to configure prevalence and incidence rates for cobalt asthma. IgE and IgG antibodies with cobalt specificity have been demonstrated, but T-lymphocytes and eosinophils involvement seem to be important in the mechanism of an allergic inflammation in the airways. Such an immunological pathogenesis links cobalt asthma with other manifestation of hard metal disease.
authors.affiliation: Occupational Health Unit, Cremonensis Hospital, Cremona, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Cirla
mesh_terms: D000906:Antibodies / Q000097:blood; D001249:Asthma / Q000139:chemically induced* / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D003035:Cobalt / Q000009:adverse effects*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008213:Lymphocyte Activation; D009784:Occupational Diseases / Q000139:chemically induced* / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D015995:Prevalence
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D003035:Cobalt