[Pharmacokinetic characteristics of tetramethylpyrazine and study on hemorheology in rat model of spleen deficiency syndrome].
In this experiment, the essence of Spleen Deficiency Syndrome (SDS) was explored with the rat model of SDS using tetramethylpyrazine (TMP). 120 Wistar rats were divided into two groups, 60 each for control and test group, they were treated with normal saline and reserpine respectively. The hemorheological parameters were also studied in 6 each of both groups. The pharmacokinetic properties were investigated in the remaining control group and test group.


RESULTS
(1) Two-compartment open model of the control group was turned into that of one-compartment in test group; (2) The SDS model significantly affected the absorption and distribution of TMP in rats. AUC was much higher and serum concentration of TMP increased significantly than that of control. Hemorheological parameters (viscosity of whole blood, fibrinogen, etc.) increased significantly (P < 0.05-0.01), it demonstrated that the SDS model was in a state of Blood Stasis. It might be one of the pharmacokinetic mechanisms of TMP in the SDS model of rats.
Huang
X
X
Xijing Hospital, Fourth Military Medical University, Xi'an.
Ren
P
P
Wen
A D
AD
D000818:Animals; D018056:Hemorheology; D008297:Male; D011719:Pyrazines / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine; D013158:Splenic Diseases / Q000097:blood* / Q000139:chemically induced / Q000378:metabolism; D016711:Yang Deficiency / Q000097:blood* / Q000139:chemically induced / Q000378:metabolism
D011719:Pyrazines; D012110:Reserpine; C017953:tetramethylpyrazine