[Skin reaction to OK-432 and its dosage for locoregional administration].
Establishment of optimal dosage of OK-432, a streptococcal preparation, was studied based on its skin test was studied. Locoregional immunotherapy using OK-432 was conducted for patients with malignant fluids. More OK-432 was administered to patients having a weaker skin reaction to OK-432 and less to those having a stronger one, corresponding to their redness diameter of skin reaction. There was a marked difference in OK-432-skin test among patients. Some patients with malignant fluids having small redness responded to the treatment after a large amount of OK-432, and others were well controlled by a smaller dosage of OK-432. It is suggested that OK-432-skin test may provide the optimal dosage for local treatment of malignant fluids.
Yamaguchi
Y
Y
Dept. of Surgery, Hiroshima University.
Noma
K
K
Miyahara
E
E
Funakoshi
M
M
Takashima
I
I
Kawami
H
H
Sawamura
A
A
Toge
T
T
D001202:Ascitic Fluid / Q000209:etiology / Q000628:therapy*; D001943:Breast Neoplasms / Q000150:complications; D010478:Chemotherapy, Cancer, Regional Perfusion; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications*; D006801:Humans; D007167:Immunotherapy; D015552:Injections, Intralesional; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D010844:Picibanil / Q000008:administration & dosage*; D012867:Skin / Q000276:immunology*; D012882:Skin Tests
D010844:Picibanil