Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine.
Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAd-CAM-1, which is a vascular recognition molecule (adressin) selectively expressed on mucosal endothelium. The expression of the alpha 4 beta 7 mucosal homing receptor was studied in eight cases of malignant lymphomatous polyposis (MLP). This unusual presentation of non-Hodgkin's lymphoma of mantle cell type is characterized by multifocal lymphomatous involvement of the gastrointestinal tract. Unlike nodal mantle cell lymphomas, cases of MLP showed expression of alpha 4 beta 7, suggesting that this homing receptor plays an important role in determining the characteristic mucosal dissemination pattern of MLP.
Pals
S T
ST
Department of Pathology, University of Amsterdam, The Netherlands.
Drillenburg
P
P
Dragosics
B
B
Lazarovits
A I
AI
Radaszkiewicz
T
T
D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D016023:Integrins / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D007417:Intestinal Polyps / Q000276:immunology* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000378:metabolism; D009361:Neoplasm Invasiveness; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; C504265:MADCAM1 protein, human; D009088:Mucoproteins; D016201:Receptors, Lymphocyte Homing; C070709:integrin alphaEbeta7