title: Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors.
authors.affiliation: Medicinal Chemistry Research, Upjohn Laboratories, Kalamazoo, Michigan 49001.
authors.forename: S
authors.initials: S
authors.lastname: Thaisrivongs
authors.forename: P K
authors.initials: PK
authors.lastname: Tomich
authors.forename: K D
authors.initials: KD
authors.lastname: Watenpaugh
authors.forename: K T
authors.initials: KT
authors.lastname: Chong
authors.forename: W J
authors.initials: WJ
authors.lastname: Howe
authors.forename: C P
authors.initials: CP
authors.lastname: Yang
authors.forename: J W
authors.initials: JW
authors.lastname: Strohbach
authors.forename: S R
authors.initials: SR
authors.lastname: Turner
authors.forename: J P
authors.initials: JP
authors.lastname: McGrath
authors.forename: M J
authors.initials: MJ
authors.lastname: Bohanon
mesh_terms: D015110:4-Hydroxycoumarins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D001682:Biological Availability; D003460:Crystallization; D004285:Dogs; D015195:Drug Design; D016333:HIV Protease / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats
chemical_list: D015110:4-Hydroxycoumarins; D017320:HIV Protease Inhibitors; D011753:Pyrones; C089699:U 96988; D016333:HIV Protease