title: [The heterogeneity of populations of the Escherichia coli recombinant strain KS 1561--a producer of thermolabile enterotoxin during stab cultivation].
abstract: In the process of the submerged cultivation of E. coli gene engineering strain KS 1561 carrying hybridization plasmid controlling the synthesis of thermolabile enterotoxin LT. The dissociation of the initial strain with the formation of two populations with different properties was observed. One population was characterized by the capacity of fermenting lactose and had decreased activity on the production of LT; the other population, which was lactose-negative, was capable of its increased synthesis.
authors.forename: L D
authors.initials: LD
authors.lastname: Martynenko
authors.forename: A V
authors.initials: AV
authors.lastname: Aleshukina
authors.forename: L P
authors.initials: LP
authors.lastname: Zemliankina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Ezepchuk
mesh_terms: D003470:Culture Media; D004768:Enterotoxins / Q000032:analysis / Q000096:biosynthesis*; D004926:Escherichia coli / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D006358:Hot Temperature; D007785:Lactose / Q000378:metabolism; D011995:Recombination, Genetic; D013997:Time Factors
chemical_list: D003470:Culture Media; D004768:Enterotoxins; D007785:Lactose
vernacular_title: Geterogennost' populiatsiĭ rekombinantnogo shtamma Escherichia coli KS 1561--produtsenta termolabil'nogo énterotoksina v protsesse glubinnogo kul'tivirovaniia.