Transient neonatal diabetes mellitus: a relapse after 10 years of complete remission.
The follow-up study of a patient with permanent diabetes (DM) unrelated to islet cell antibody and anti-insulin antibodies and occurring 10 years after a transient neonatal DM episode is reported. A latent defect in insulin release was proved. It produced transient glucosuria during intercurrent illnesses and permanent hyperglycaemia and a decrease in growth velocity [with high stimulated growth hormone and low insulin-like growth factor I (IGF-I)] at the onset of puberty. After insulin therapy was re-introduced, catch-up growth and normalization of the blood glucose and IGF-I levels were noted.
Vanelli
M
M
Department of Pediatrics, University of Parma, Italy.
De Fanti
A
A
Cantoni
S
S
Chiari
G
G
D001323:Autoantibodies / Q000097:blood; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006029:Glycosuria; D006128:Growth; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D012008:Recurrence; D012075:Remission, Spontaneous
D001323:Autoantibodies; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; C024211:islet cell antibody