Metastatic adamantinoma diagnosed by fine-needle aspiration biopsy of the lung.
We report two cases of metastatic adamantinoma to the lung diagnosed by FNAB. The cytologic appearance of the smears of each case was homogenous, containing small round and spindle cells with indistinct cytoplasm. The nuclei had delicate nuclear membranes, with finely dispersed chromatin and occasional micronucleoli. No pleomorphism was noted. Immunocytochemistry exhibited positive staining for keratin and vimentin. EM examination revealed numerous tonofilaments and well formed desmosomes. The cytologic diagnosis of metastatic adamantinoma can be made with the knowledge of a previous history of adamantinoma of bone, the comparison of the metastatic tumor with the original bone tumor, and the awareness of the long latency of the metastases. Immunocytochemistry and EM are needed to substantiate the diagnosis.
Perez-Ordonez
B
B
Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Bedard
Y C
YC
D000328:Adult; D000564:Ameloblastoma / Q000473:pathology* / Q000556:secondary; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary; D008297:Male; D008854:Microscopy, Electron