title: TAP1 and TAP2 polymorphism in multiple sclerosis patients.
abstract: The frequency of TAP1 and TAP2 gene polymorphisms in MS patients was compared with that of a normal population. A significant increase in TAP2-379-VAL homozygosity and TAP2-565-ALA homozygosity was found in HLA-DRB1*1501-DQB1*0602-negative patients.
authors.affiliation: Northern Ireland Tissue Typing Service, City Hospital.
authors.forename: D
authors.initials: D
authors.lastname: Middleton
authors.forename: G
authors.initials: G
authors.lastname: Megaw
authors.forename: C
authors.initials: C
authors.lastname: Cullen
authors.forename: S
authors.initials: S
authors.lastname: Hawkins
authors.forename: C
authors.initials: C
authors.lastname: Darke
authors.forename: D A
authors.initials: DA
authors.lastname: Savage
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D006684:HLA-DR Antigens; C073119:TAP1 protein, human; C071692:TAP2 protein, human