The lack of melatonin rhythm in active acromegaly after radiotherapy.
The aim of the study was to evaluate the interrelation between the levels of growth hormone (GH), prolactin (PRL), somatomedin-C (Sm-C) and melatonin determined at 3 h intervals over a 24 h period (8.00, 11.00, 14.00, 17.00, 20.00, 23.00, 2.00 and 5.00) in 8 acromegalic patients after radiotherapy. The circadian rhythms and the interrelation between hormone and Sm-C levels were evaluated using Halberg's cosinor method and the correlation analysis, respectively. We observed a total abolition of melatonin rhythm with significantly lower nocturnal values in all patients which could be due to earlier radiotherapy.
Zwirska-Korczala
K
K
I Department of Pathophysiology and Clinical Biochemistry, Silesian Academy of Medicine, Zabrze, Poland.
Ostrowska
Z
Z
Kos-Kudła
B
B
Buntner
B
B
Zych
F
F
D000172:Acromegaly / Q000503:physiopathology / Q000532:radiotherapy*; D000328:Adult; D002940:Circadian Rhythm / Q000528:radiation effects*; D005069:Evaluation Studies as Topic; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008875:Middle Aged; D011388:Prolactin / Q000378:metabolism*; D011878:Radiotherapy / Q000009:adverse effects
D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013006:Growth Hormone; D008550:Melatonin