Weekly low-dose methotrexate therapy for sarcoidosis.
Low-dose methotrexate therapy has been used to treat a variety of chronic inflammatory diseases; a few studies have discussed the efficacy of this therapy for sarcoidosis. We present a patient with symptomatic sarcoidosis who was successfully treated with low-dose methotrexate after being refractory to steroids. This patient showed significant clinical improvement without development of any severe side effects. These findings suggest that low-dose methotrexate therapy may be a useful alternative treatment for sarcoidosis.
Suda
T
T
Department of Internal Medicine, Hamamatsu University School of Medicine.
Sato
A
A
Toyoshima
M
M
Imokawa
S
S
Yoshitomi
A
A
Tamura
R
R
Suganuma
H
H
Yagi
T
T
Hayakawa
H
H
Shirai
M
M
D000328:Adult; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000188:drug therapy*
D008727:Methotrexate