Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease.
Hyman
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Neurology Service, Massachusetts General Hospital, Boston 02114.
Gomez-Isla
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D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002452:Cell Count; D002540:Cerebral Cortex / Q000473:pathology; D006801:Humans; D009474:Neurons / Q000502:physiology