title: Acute pneumonitis after subcutaneous injections of silicone for augmentation mammaplasty.
abstract: In a period of 3 years, seven cases of acute pneumonitis have been found after patients have been subcutaneously injected with silicone for the sole purpose of augmentation mammaplasty. Adverse symptoms following these silicone injections were fever, hypoxemia, hemoptysis, and abnormal diffuse bilateral alveolar infiltrates in both lungs. Pulmonary hemorrhaging occurred, and this was substantiated by using the bronchoscope with the bronchoalveolar lavage (BAL). The alveolar macrophage obtained from the BAL contained large quantities of pleomorphic cytoplasmic particles, which in actual fact were silicone particles. They were identified as silicone by scanning electron microscopy and energy-dispersive analysis of x-rays. This evidently showed that silicone diffusion into the circulatory system and subsequent embolization of the lung. Pulmonary function studies had shown restrictive changes with increase or normal single-breath carbon monoxide diffusing capacity (Dsb). Perfusion lung scans were interpreted as showing diffuse abnormalities consisting of decreased peripheral uptake. Acute hypoxemic respiratory failure was noted in four of these patients. Silicone injections of this nature were therefore a respiratory risk and caused the inducement of pneumonitis.
authors.affiliation: Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan, Republic of China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Lai
authors.forename: T Y
authors.initials: TY
authors.lastname: Chao
authors.forename: S L
authors.initials: SL
authors.lastname: Wong
mesh_terms: D000208:Acute Disease; D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000737:chemistry / Q000648:ultrastructure; D007279:Injections, Subcutaneous; D016676:Macrophages, Alveolar / Q000648:ultrastructure; D016462:Mammaplasty / Q000009:adverse effects / Q000379:methods*; D008854:Microscopy, Electron; D011014:Pneumonia / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D012828:Silicones