Effect of fibrosarcoma induction on copper and ceruloplasmin concentration in different organs of the host.
The copper content and ceruloplasmin activity were determined in mice bearing benzo(a)pyrene induced fibrosarcoma. The copper level and ceruloplasmin activity in different organs of fibrosarcomatous mice varied when compared to their controls. Significant changes in copper and ceruloplasmin concentration were observed in the liver and tumor tissue of host mice bearing fibrosarcoma compared to controls. Disturbed copper metabolism at the hepatic level may account for the hypercupremia observed during malignancy.
Chakravarty
P K
PK
Chittaranjan National Cancer Institute, Calcutta, India.
Ghosh
A
A
Chowdhury
J R
JR
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D005354:Fibrosarcoma / Q000139:chemically induced / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D008805:Mice, Inbred A; D009206:Myocardium / Q000378:metabolism; D013154:Spleen / Q000378:metabolism
D003300:Copper; D002570:Ceruloplasmin