Genetic dissection of consolidated memory in Drosophila.
Behavioral and pharmacological experiments in many animal species have suggested that memory is consolidated from an initial, disruptable form into a long-lasting, stable form within a few hours after training. We combined these traditional approaches with genetic analyses in Drosophila to show that consolidated memory of conditioned (learned) odor avoidance 1 day after extended training consisted of two genetically distinct, functionally independent memory components: anesthesia-resistant memory (ARM) and long-term memory (LTM). ARM decayed away within 4 days, was resistant to hypothermic disruption, was insensitive to the protein synthesis inhibitor cycloheximide (CXM), and was disrupted by the radish single-gene mutation. LTM showed no appreciable decay over 7 days, was sensitive to CXM, and was not disrupted by the radish mutation.
Tully
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Cold Spring Harbor Laboratory, New York 11724.
Preat
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T
Boynton
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SC
Del Vecchio
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M
D000818:Animals; D001362:Avoidance Learning; D001923:Brain Chemistry / Q000187:drug effects; D003214:Conditioning, Classical; D003513:Cycloheximide / Q000494:pharmacology; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D017344:Genes, Insect / Q000235:genetics; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009154:Mutation / Q000502:physiology
D003513:Cycloheximide