Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease.
Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer's disease (AD). In order to investigate whether these changes are associated with compromised blood-brain transport mechanisms, hippocampal formation sections from AD and age-matched normal brains were immunolabelled with an antibody to the GLUT-1 glucose transporter protein. GLUT-1 immunolabelling of microvessel endothelium was significantly reduced in the AD compared to normal hippocampal formation. Thus, AD is associated with a reduction in cerebral microvessel endothelium glucose transporter content, which may result in decreased glucose availability to the brain.
Horwood
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Department of Anatomy, St. George's Hospital Medical School, Tooting, London, UK.
Davies
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DC
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D051272:Glucose Transporter Type 1; D006624:Hippocampus / Q000098:blood supply*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008833:Microcirculation; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*
D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; C495677:SLC2A1 protein, human