Results of the administration of bisphosphonates for the prevention of periosteal bone formation following Moloney sarcoma virus-induced tumors.
The effect of continuous and discontinuous administration of bisphosphonates on the periosteal osteogenesis induced by Moloney sarcoma development was studied in mice by histological examination and bone dry mass evaluation. Both EHDP and Cl2MDP did not inhibit periosteal osteogenesis but EHDP, in contrast to Cl2MDP, inhibited the mineralization of osteoid. This inhibition was completely reversible after the withdrawal of the drug. Within two weeks the remineralization of newly formed bone matrix was completed.
Włodarski
P
P
Department of Histology and Embryology, Medical Academy of Warsaw.
Włodarski
K
K
Galus
K
K
Luczak
M
M
D000818:Animals; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008980:Moloney murine sarcoma virus; D010012:Osteogenesis / Q000187:drug effects*; D010521:Periosteum / Q000187:drug effects*; D012192:Retroviridae Infections / Q000503:physiopathology; D012513:Sarcoma, Experimental / Q000503:physiopathology*; D014412:Tumor Virus Infections / Q000503:physiopathology
D004164:Diphosphonates