S-100-positive T-cell lymphoproliferative disorder. A case report and review of the literature.
The authors describe a patient with a S-100-positive T-cell lymphoproliferative disorder, characterized by clinically aggressive behavior, with leukemic dissemination and death within 1 year of the onset of symptoms. The neoplastic cells had abundant amphophilic cytoplasm, suggestive of plasmacytoid differentiation, but demonstrated a mature T-cell immunophenotype characteristic of the suppressor-cytotoxic subset. In addition, the cells expressed the S-100 protein within the cytoplasm. Genotypic studies were performed by Southern blot analysis, which demonstrated beta-chain T-cell receptor gene rearrangement, further confirming the T-cell nature of this disorder. This case had features very similar to those of the seven cases previously reported. It has been proposed that the S-100-positive T-cell lymphoproliferative disorder is a distinctive clinicopathologic entity.
Zarate-Osorno
A
A
Hematopathology Section, National Cancer Institute, Bethesda, Maryland.
Raffeld
M
M
Berman
E L
EL
Ferguson
M M
MM
Andrade
R
R
Jaffe
E S
ES
D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008854:Microscopy, Electron; D009418:S100 Proteins / Q000032:analysis*
D009418:S100 Proteins