Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model.
Loci linked to sensitivity to dietary obesity were identified by Quantitative Trait Locus (QTL) analysis of two mapping populations derived from a cross between AKR/J and SWR/J mice. AKR/J mice are sensitive to dietary obesity when fed a high fat diet while SWR/J mice are resistant. Intercrosses between these strains segregate the phenotype of sensitivity to dietary obesity. Using an F2 mapping population of 931 male mice we found significant linkage with a QTL on chromosome 9 (Likelihood of the Odds [LOD] ratio of 4.85) and another QTL on chromosome 15 (LOD = 3.93). The presence of a QTL on chromosome 15 was confirmed in a separate mapping population of 375 male F1 x SWR/J mice (LOD = 3.82). These two loci are designated dietary obese 2 (Do2) and dietary obese 3 (Do3) for the chromosome 9 and 15 loci, respectively. Both of these chromosomal regions contain candidate genes which may contribute to variation in the phenotype. These loci also exert a significant control over individual adipose depot weights.
West
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DB
Obesity, Diabetes and Metabolism Section, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808.
Goudey-Lefevre
J
J
York
B
B
Truett
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GE
D000273:Adipose Tissue; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D003433:Crosses, Genetic; D004032:Diet; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008815:Mice, Inbred Strains; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic
D005819:Genetic Markers