title: Effects of 252Cf neutrons, transmitted through an iron block on human lymphocyte chromosome.
abstract: Chromosome aberration of human peripheral blood lymphocytes exposed to californium-252 (252Cf) neutrons transmitted through a 15 cm thick iron block was analysed. The spectrum of the filtered neutrons ranged from 0.1 to 2 MeV with a peak at 0.7 MeV, simulating the Hiroshima atomic bomb neutron spectrum as shown in the Dosimetry System 1986 (DS86). Chromosome aberration frequencies after exposure to filtered and unfiltered 252Cf radiation were compared. Acentric ring chromosomes were significantly increased (p < 0.05) in the filtered condition. However, yields of dicentrics and centric rings induced by the filtered neutrons were not statistically different from those induced by the unfiltered neutrons (p > 0.1). The relative biological effectiveness (RBE) of the neutrons with respect to the formation of dicentrics and centric rings was 10.9 and 12.3 in the filtered and unfiltered conditions respectively, but the difference was not statistically significant. These results provide useful information for the re-evaluation of the biological effect of the Hiroshima atomic bomb radiations.
authors.affiliation: Department of Hematology, Hiroshima University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Hoshi
authors.forename: S
authors.initials: S
authors.lastname: Sawada
authors.forename: N
authors.initials: N
authors.lastname: Kamada
mesh_terms: D002142:Californium; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron; D008214:Lymphocytes / Q000528:radiation effects*; D009502:Neutrons; D011868:Radioisotopes; D012062:Relative Biological Effectiveness
chemical_list: D011868:Radioisotopes; D002142:Californium; D007501:Iron