Correlation of octanol-water partition coefficients with capacity factors measured by micellar electrokinetic chromatography.
Micellar electrokinetic chromatography (MEKC) was used to measure hydrophobicity of 18 aromatic compounds. The capacity factors, which are proportional to the micelle-water distribution coefficients, were closely correlated with the octanol-water partition coefficients. The addition of Brij 35 to the charged micelle was effective in improving the correlation because the surface charges of the micelle were shielded.
Ishihama
Y
Y
Department of Physical and Analytical Chemistry, Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
Oda
Y
Y
Uchikawa
K
K
Asakawa
N
N
D002845:Chromatography; D004563:Electrochemistry; D008823:Micelles; D000442:Octanols / Q000737:chemistry*; D000077423:Polidocanol; D011092:Polyethylene Glycols; D012995:Solubility; D014014:Tissue Adhesives; D014867:Water / Q000737:chemistry*
D008823:Micelles; D000442:Octanols; D014014:Tissue Adhesives; D014867:Water; D000077423:Polidocanol; D011092:Polyethylene Glycols