The many guises of amyloidosis. Clinical presentations and disease associations.
Amyloidosis occurs in association with many diseases and can also be idiopathic. It is usually a systemic disease with variable presentations. The diagnosis should be suspected in patients with unexplained proteinuria, cardiomyopathy, congestive heart failure, peripheral neuropathy, carpal tunnel syndrome, macroglossia, or hepatosplenomegaly. Amyloidosis generally has a poor prognosis and responds poorly to therapy. Much needs to be learned about its pathogenesis and treatment possibilities.
Vogelgesang
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Walter Reed Army Medical Center, Washington, DC.
Klipple
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D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans