[Use of anti-radical protection enzymes in the treatment of acute experimental pancreatitis].
Effect of the complex of antiradical enzymes (superoxide dismutase and catalase in proportion 1:3) was studied on the experimental mode of acute pancreatitis. After thrice repeated administration of a complex of enzymes, antioxidant capacity of the blood serum normalized, activity of the enzymes of antioxidant protection of an organism and that of glucose-6-phosphate dehydrogenase increased, concentration of extra-erythrocytic hemoglobin decreased, contributing to normalization of morphologic structure of the pancreas in 52% of the animals with hemorrhagic and in 70%--with oedematous form pancreatitis. The results obtained are indicative of possible correction of the changes in inflammatory process in the pancreas.
Rusakov
V I
VI
Shepelev
A P
AP
Svechnikova
L V
LV
Bubnova
V I
VI
Furs
L N
LN
Chernogubova
E A
EA
Kalmykova
Iu A
IuA
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000494:pharmacology / Q000627:therapeutic use*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood / Q000187:drug effects; D006454:Hemoglobins / Q000187:drug effects; D017665:Hydroxyl Radical; D015227:Lipid Peroxidation / Q000187:drug effects; D008954:Models, Biological; D010195:Pancreatitis / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D013482:Superoxide Dismutase / Q000494:pharmacology / Q000627:therapeutic use*
D000975:Antioxidants; D006454:Hemoglobins; D017665:Hydroxyl Radical; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D013482:Superoxide Dismutase
Primenenie fermentov antiradikalńoĭ zashchity v lechenii ostrogo éksperimentalńogo pankreatita.