Monitoring the partitioning of hepatic fatty acids in vivo: keeping track of control.
Noninvasive labelling of hepatic fatty acids in conscious, unrestrained rats shows how liver lipid metabolism responds acutely to physiological perturbations, such as the starved-to-refed transition. The speed with which the liver switches from fatty acid oxidation to esterification varies widely according to the requirement of the animal for continued synthesis of glucose 6-phosphate from three-carbon precursors. Ingestion of a meal also provides a strong signal for the diversion of fatty acids away from triacylglycerol synthesis and secretion, but insulin may only play an indirect role in this effect.
Zammit
V A
VA
Department of Biochemistry and Molecular Biology, Hannah Research Institute, Ayr, UK.
Moir
A M
AM
D000818:Animals; D002250:Carbon Radioisotopes; D002788:Cholesterol Esters; D002914:Chylomicrons; D005227:Fatty Acids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats
D002250:Carbon Radioisotopes; D002788:Cholesterol Esters; D002914:Chylomicrons; D005227:Fatty Acids