Cytogenetic findings in squamous cell carcinoma of the oral cavity.
A case of squamous cell carcinoma (SCC) of the oral cavity is presented which, in addition to normal metaphases, cytogenetically displayed two cell clones with chromosomal aberrations: 46,XY,1+del(5)(q13),der(18)t(5;18)(q13;p11),-5 and 49,XY,+5,+7,+10 After a review of the literature of the few cytogenetically analyzed cases, the findings confirm the multiclonal origin of oral SCC and also the commonly seen aberrations of chromosome 5.
Füzesi
L
L
Institute of Pathology, Medical School of the Technical University of Aachen, Germany.
Braun
S
S
Gunawan
B
B
Schmitz
H J
HJ
Mittermayer
C
C
D000368:Aged; D002278:Carcinoma in Situ / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D003582:Cytogenetics; D006801:Humans; D008297:Male; D010157:Palatal Neoplasms / Q000235:genetics*