[What can be expected of the microscopic study of a biopsy of the accessory salivary glands? An argument for a new approach: "D.D." (diagnosis, destruction)].
Histological study is made on labial salivary gland biopsies in three usual circumstances: presence of a sicca syndrome; suspicion of a Gougerot-Sjogren's disease or of another systemic disease (sarcoïdosis; amyloïdosis). Its aim is: to appreciate the accuracy of the biopsy; to analyse elementary lesions and to suggest an etiologic diagnosis. The authors put emphasis on the interest: 1) to use new techniques of immunocytochemistry or molecular biology to appreciate the degree of evolutivity of lesions; 2) to quantify lymphoïd infiltrates, fibrosis and epithelial alterations; 3) to formulate results with regard not only to the etiological Diagnosis but also to the glandular Destruction by means of a double descriptive score: the "D.D." score.
Le Charpentier
Y
Y
Service central d'anatomie et cytologie pathologiques, Groupe hospitalier Pitié-Salpêtrière, Paris.
Auriol
M
M
D000686:Amyloidosis / Q000175:diagnosis / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000473:pathology; D008853:Microscopy; D012466:Salivary Gland Diseases / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D012470:Salivary Glands, Minor / Q000473:pathology*; D012507:Sarcoidosis / Q000175:diagnosis / Q000473:pathology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000473:pathology; D013048:Specimen Handling
Qu'attendre de l'étude au microscope d'une biopsie de glandes salivaires accessoires (G.S.A.)? Plaidoyer pour une nouvelle approche: "D.D." (diagnostic, destruction).