Effects of total fasting or chronic food restriction on plasma endothelin levels in rats.
We tested the effects of 24- and 48-h fasting and 40% calorie restriction stresses on plasma endothelin (ET)-1,2 levels in male Sprague-Dawley rats. Plasma ET-1,2 levels in pg/ml were lower in 24-h fasted rats (15.48 +/- 3.49), 48-h fasted rats (5.28 +/- 4.32), and in chronically food-deprived rats (R) (10.49 +/- 6.28) compared to ad lib-fed (AL) rats (21.23 +/- 9.38). The R rats were pair-fed 40% fewer calories than AL rats. We conclude that calorie restriction or total food deprivation stress decreases plasma ET-1,2 levels, unlike many other forms of physiological stress that have been shown to increase plasma ET-1,2 levels.
Mehta
R S
RS
Department of Pharmacology and Toxicology, College of Pharmacy, University of Georgia, Athens 30602-2356.
Hartle
D K
DK
D000818:Animals; D001143:Arousal / Q000502:physiology; D016232:Endothelins / Q000097:blood*; D005215:Fasting / Q000097:blood*; D005508:Food Deprivation / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D016232:Endothelins