Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
Serino
F
F
University of Texas, Houston.
Grevel
J
J
Napoli
K L
KL
Kahan
B D
BD
Strobel
H W
HW
D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology; D016572:Cyclosporine / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D004790:Enzyme Induction; D016166:Free Radical Scavengers / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D016166:Free Radical Scavengers; D000632:Aminopyrine; D009249:NADP; D002701:Chloramphenicol; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System; D011335:Proadifen; D007654:Ketoconazole; D010634:Phenobarbital