title: Exposure to epichlorohydrin and central nervous system neoplasms at a resin and dye manufacturing plant.
abstract: This study evaluated the relationship between central nervous system neoplasms (CNSN) and exposure to epichlorohydrin (ECH) among 11 CNSN cases and 44 controls who were members of a cohort of chemical workers. Information on area of employment and potential exposure to ECH was obtained from plant personnel and medical records and from interviews with long-term employees. An elevated odds ratio (OR) for CNSN was observed for subjects who worked in the epoxy resin process line (OR = infinity, 95% confidence interval [CI] = 1.2-infinity), and in the production of anthraquinone intermediate dyes (OR = infinity, 95% CI = 1.7-infinity) and azo dyes (OR = 3.6, 95% CI = 0.6-41). Routine potential exposure to ECH was associated with CNSN (OR = 4.2, 95% CI = 0.7-26). Dose-response relationships were found with duration and with cumulative routine potential exposure to ECH (p = .11 and .08, respectively). Acute exposure to ECH requiring treatment at the plant infirmary also was associated with subsequent CNSN (OR = infinity, 95% CI = 1.5-infinity).
authors.affiliation: Department of Hygiene and Epidemiology, University of Udine, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Barbone
authors.forename: E
authors.initials: E
authors.lastname: Delzell
authors.forename: H
authors.initials: H
authors.lastname: Austin
authors.forename: P
authors.initials: P
authors.lastname: Cole
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D002617:Chemical Industry; D015331:Cohort Studies; D004811:Epichlorohydrin / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D016017:Odds Ratio; D011795:Surveys and Questionnaires
chemical_list: D004811:Epichlorohydrin