Scedosporium inflatum infection in immunocompromised haematological patients.
We report four cases of Scedosporium inflatum (S. inflatum) infection in severely immunocompromised haematological patients. Six well-documented cases of S. inflatum disseminated infection in haematological patients have been reported: four in Australia and two in Spain. Their clinical and pathological characteristics are heterogenous, particularly in the Australian cases. However, the clinical and pathological profile emerging from our and other Spanish cases is homogenous and very similar to the clinico-pathological spectrum of other disseminated mycoses, including Aspergillus and S. apiospermum. The optimal treatment of S. inflatum infection is unknown and the outcome in haematological patients is very poor. Eight patients died despite systemic antifungal treatment.
Tapia
M
M
Department of Haematology, Marqués de Valdecilla University Hospital, University of Cantabria, Spain.
Richard
C
C
Baro
J
J
Salesa
R
R
Figols
J
J
Zurbano
F
F
Zubizarreta
A
A
D000666:Amphotericin B / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007938:Leukemia / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology*; D009181:Mycoses / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D009894:Opportunistic Infections / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D016896:Treatment Outcome
D000666:Amphotericin B