Allogeneic skin grafting for extensive skin chronic graft-versus-host disease.
A 35-year-old female with chronic myelogenous leukemia in chronic phase underwent allogeneic bone marrow transplantation from her genotypically-matched brother in 1990. The extensive chronic graft-versus-host skin disease supervened with skin ulcers on both lower legs in 1992. Conservative therapy was unsuccessful for these lesions. Therefore, not only autologous skin grafting but also allogeneic skin grafting from the marrow donor was successfully performed. She has been maintaining her daily activities (Karnofsky performance status 90%) with little limitation for 17 months after the final skin grafting.
Kondo
S
S
Blood Transfusion Division, Miyazaki Medical College, Japan.
Tamura
K
K
Makino
S
S
Takamatsu
Y
Y
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000601:surgery*; D006801:Humans; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000209:etiology / Q000601:surgery*; D014184:Transplantation, Homologous