title: Evaluation of Epstein-Barr virus antibody patterns and detection of viral markers in the biopsies of patients with Hodgkin's disease.
abstract: We assessed the relationship of Epstein-Barr virus (EBV) serology to the presence or absence of EBV genome in 39 cases of Hodgkin's disease (HD). Biopsies from patients included in 2 previous published studies, 1 involving patients from the United States (eastern Massachusetts) and 1 from Denmark, were evaluated for EBV (EBER-1) and latent membrane protein (LMP-1). The presence of EBV in Reed-Sternberg cells in the biopsies correlated with the histologic subtype of HD (mixed cellularity and lymphocyte depletion) but not with IgG antibody titers against the viral capsid antigen (VCA). These data suggest that, unlike Burkitt's lymphoma, the IgG antibody against VCA is not predictive of the presence or absence of EBV in Reed-Sternberg cells in HD. The predictive value of other antibodies should be evaluated.
authors.affiliation: Viral Epidemiology Branch, National Cancer Institute, Bethesda, MD.
authors.forename: P H
authors.initials: PH
authors.lastname: Levine
authors.forename: G
authors.initials: G
authors.lastname: Pallesen
authors.forename: P
authors.initials: P
authors.lastname: Ebbesen
authors.forename: N
authors.initials: N
authors.lastname: Harris
authors.forename: A S
authors.initials: AS
authors.lastname: Evans
authors.forename: N
authors.initials: N
authors.lastname: Müeller
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D001706:Biopsy; D002213:Capsid / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis*; D003718:Denmark; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology*; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016539:Reed-Sternberg Cells / Q000473:pathology; D014481:United States
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G