[The immunological efficacy of Francisella tularensis outer membranes for hamadryas baboons].
The protective properties of the preparation of F. tularensis outer membranes (OM), obtained from F. tularensis vaccine strain 15, were studied in experiments on hamadryas baboons challenged subcutaneously with F. tularensis virulent strain Schu (nonarctic subspecies). The subcutaneous immunization with the OM preparation prevented the development of clinically pronounced infection in more than 70% of the monkeys challenged with F. tularensis strain Schu in a dose of 787 live microbial cells 30 days after immunization. Antibody titers determined in the immunized monkeys with the use of the agglutination test (AT) and the passive hemagglutination test (PHAT) were usual in minimal diagnostic limits (1:80 for AT and 1:320 for PHAT) and did not significantly rise by day 20 after immunization. In all intact animals infected with F. tularensis strain Schu the development of the infectious process was registered, which was accompanied by a rise in temperature exceeding 39.5 degrees C and a rise in the titer of specific antibodies.
Khlebnikov
V S
VS
Golovlev
I R
IR
Zhemchugov
V E
VE
Chugunov
A M
AM
Averin
S F
SF
Afanas'ev
S S
SS
Kalachev
I Ia
IIa
Pchelintsev
S Iu
SIu
Kislichkin
N N
NN
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005604:Francisella tularensis / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D007114:Immunization; D008297:Male; D008992:Monkey Diseases / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D010215:Papio / Q000276:immunology*; D013997:Time Factors; D014406:Tularemia / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D014774:Virulence
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins
Immunologicheskaia éffektivnost' vneshnikh membran Francisella tularensis dlia obez'ian-gamadril.