title: [A trial of the long-term use of a low-protein diet and ketosteril in chronic kidney failure].
abstract: Ten CRF patients (mean glomerular filtration rate 10.1 ml/min) were put on low-protein diet (0.3 g/kg protein daily) supplemented with ketosteryl (10-12 pills daily). During 3 out of 6-34 months of the diet azotemia declined: creatinine, blood urea nitrogen, uric acid, phosphorus concentrations diminished by 5%, 12%, 10% and 17%, respectively. Further accumulation of nitrogen residues slowed down. Monthly increment of serum creatinine and hemoglobin loss rate reduced 2-fold (from 0.23 to 0.117 mg% month and from 0.16 to 0.08 g% month, respectively). Protein deficiency did not occur as serum albumin and body mass remained the same, whereas urea nitrogen/creatinine ratio showed a 35% decrease. It is concluded that rigorous low-protein diet combined with keto-analogues of essential amino acids is able to abate uremia and inhibit CRF augmentation.
authors.forename: N L
authors.initials: NL
authors.lastname: Lifshin
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Nikolaev
authors.forename: V M
authors.initials: VM
authors.lastname: Ermolenko
mesh_terms: D000328:Adult; D000601:Amino Acids, Essential / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D018753:Diet, Protein-Restricted / Q000379:methods; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000178:diet therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013607:Tablets; D013997:Time Factors; D014511:Uremia / Q000178:diet therapy / Q000378:metabolism
chemical_list: D000601:Amino Acids, Essential; D013607:Tablets; C048995:ketosteril
vernacular_title: Opyt dlitel'nogo primeneniia malobelkovoĭ diety i ketosterila pri khronicheskoĭ pochechnoĭ nedostatochnosti.