The effects of 4-aminopyridine on cognitive function in patients with multiple sclerosis: a pilot study.
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function.
Smits
R C
RC
Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.
Emmen
H H
HH
Bertelsmann
F W
FW
Kulig
B M
BM
van Loenen
A C
AC
Polman
C H
CH
D015761:4-Aminopyridine / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D009483:Neuropsychological Tests; D010865:Pilot Projects; D010919:Placebos
D010919:Placebos; D015761:4-Aminopyridine