title: Myelodysplasia following paroxysmal nocturnal haemoglobinuria: evidence for the emergence of a separate clone.
abstract: A patient with paroxysmal nocturnal haemoglobinuria (PNH) who developed a myelodysplastic syndrome (MDS) is described. After the onset of myelodysplasia the neutrophils of the patient fully expressed GPI-linked proteins. It is concluded that the myelodysplasia does not originate from transformed PNH stem cells, but represents the emergence of a separate clone arising from an injured marrow.
authors.affiliation: Department of Haematology, University of Groningen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: van Kamp
authors.forename: J W
authors.initials: JW
authors.lastname: Smit
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
authors.forename: M
authors.initials: M
authors.lastname: Ruud Halie
authors.forename: E
authors.initials: E
authors.lastname: Vellenga
mesh_terms: D000754:Anemia, Refractory, with Excess of Blasts / Q000097:blood / Q000150:complications* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002999:Clone Cells / Q000473:pathology; D017261:Glycosylphosphatidylinositols / Q000097:blood; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism
chemical_list: D017261:Glycosylphosphatidylinositols