title: Reactivation of phototoxicity test for psoralens plus ultraviolet A by low-dose methotrexate.
abstract: Reactivation of a solar burn has been reported after administration of methotrexate for cancer and psoriasis patients. We report a case of psoriasis with a similar but delayed elicitation of phototoxic reaction by administration of low-dose methotrexate one month after psoralen and long-wave ultraviolet light (PUVA) treatment. The reactivation was seen in an already receding phototoxicity test area but not in a less phototoxic, noninterval PUVA treated area, suggesting that the reactivation by methotrexate is related with the severity of light-induced skin inflammation.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
authors.forename: A
authors.initials: A
authors.lastname: Fukuda
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
authors.forename: N
authors.initials: N
authors.lastname: Matsuyoshi
authors.forename: K
authors.initials: K
authors.lastname: Fujii
authors.forename: S
authors.initials: S
authors.lastname: Imamura
mesh_terms: D000368:Aged; D017484:Dermatitis, Phototoxic / Q000209:etiology*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D011701:PUVA Therapy / Q000009:adverse effects; D011565:Psoriasis / Q000188:drug therapy*; D012008:Recurrence; D013471:Sunburn / Q000209:etiology*
chemical_list: D008727:Methotrexate