title: Thyroid autoantibodies in serum samples with abnormal TSH levels.
abstract: Serum samples with normal and abnormal levels of thyrotropin (TSH) were tested for thyroid autoantibodies. Thyroid peroxidase (TPO) antibodies were detected by a radioimmunoassay (RIA) and by an agglutination method, and thyroglobulin (Tg) antibodies by an agglutination method. Elevated levels of TPO antibodies were detected in 47% of samples with abnormal and in 12% of samples with normal levels of TSH (p < 0.001). Sixty-one percent of the biochemically hypothyroid and 26% of the biochemically hyperthyroid samples contained these antibodies (p < 0.001). Tg antibodies were only detected together with TPO antibodies. Testing of TPO antibodies from samples with abnormal TSH levels is discussed.
authors.affiliation: Department of Bacteriology and Immunology, University of Helsinki, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Kontiainen
authors.forename: L
authors.initials: L
authors.lastname: Melamies
authors.forename: A
authors.initials: A
authors.lastname: Miettinen
authors.forename: T
authors.initials: T
authors.lastname: Weber
mesh_terms: D000328:Adult; D000367:Age Factors; D000372:Agglutination Tests; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology; D007037:Hypothyroidism / Q000276:immunology; D007453:Iodide Peroxidase / Q000037:antagonists & inhibitors; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013954:Thyroglobulin / Q000037:antagonists & inhibitors; D013961:Thyroid Gland / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood*
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D013972:Thyrotropin; D013954:Thyroglobulin; D007453:Iodide Peroxidase