title: Postpartum anovulation in non-nursing monkeys: hypothalamic-pituitary-ovarian refractoriness is not induced by the milieu of early pregnancy.
abstract: To evaluate the role of the early pregnancy milieu in inducing postpartum refractoriness of the hypothalamic-pituitary-ovarian axis, pregnancies in rhesus monkeys were terminated on either day 35 of gestation or near term at 162 days. Non-nursing mothers with gestations interrupted near term resumed ovulation at a mean of 56 +/- 12 (mean +/- SE) days postpartum, in contrast to the 17 +/- 2 days required for the females having had abortions at day 35. These results demonstrate that the early pregnancy milieu is not determinant of the hypothalamic-pituitary-ovarian refractoriness observed in non-nursing mothers delivering at term.
authors.affiliation: Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23507.
authors.forename: K
authors.initials: K
authors.lastname: Gordon
authors.forename: R F
authors.initials: RF
authors.lastname: Williams
mesh_terms: D000028:Abortion, Induced; D000704:Analysis of Variance; D000818:Animals; D000858:Anovulation; D002585:Cesarean Section; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007774:Lactation / Q000502:physiology; D007986:Luteinizing Hormone / Q000097:blood; D008253:Macaca mulatta; D010060:Ovulation / Q000502:physiology*; D049590:Postpartum Period / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D013997:Time Factors
chemical_list: D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone