[Genetics of colorectal cancer. Practical value].
The age and family history of colorectal cancer are the main risk factors for colorectal cancer. Taking into account the family history of colorectal cancer, the first degree relatives of a patient have a risk that increases to 2 or 3 as compared to general population. The genetic basis for colorectal cancer was recently investigated by complex segregation analysis. They favoured a dominant gene with a gene frequency of 6 :1000. These analyses represent the first step in order to localize the susceptibility genes that are responsible for the familial aggregation of colorectal cancer.
Laurent-Puig
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Laboratoire de génétique des tumeurs, institut Curie, Paris, France.
D000367:Age Factors; D015984:Causality; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005799:Genes, Dominant; D006801:Humans; D012307:Risk Factors
La génétique du cancer colorectal. Intérêt pratique.