Ketorolac-induced acute renal failure and hyperkalemia: report of three cases.
Ketorolac tromethamine (Toradol, Syntex Laboratories Inc, Palo Alto, CA) is a new nonsteroidal anti-inflammatory drug widely used in emergency departments and during the postoperative period because of its potent analgesic effects and lack of central nervous system activities. We present three new cases of acute renal failure and hyperkalemia secondary to ketorolac. All patients had at least one risk factor making them prone to the development of acute renal failure secondary to the nonsteroidal anti-inflammatory drugs. In all patients, acute renal failure developed after a moderate dose of ketorolac was administered for the management of postsurgical pain. Acute renal failure and hyperkalemia were transient, and improved after discontinuation of ketorolac treatment.
Haragsim
L
L
Division of Nephrology, St Louis University Health Sciences Center, MO. 63110.
Dalal
R
R
Bagga
H
H
Bastani
B
B
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000700:Analgesics / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced*; D020911:Ketorolac Tromethamine; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014046:Tolmetin / Q000009:adverse effects / Q000031:analogs & derivatives*; D014325:Tromethamine / Q000009:adverse effects*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004338:Drug Combinations; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D014046:Tolmetin