[Rapidly evolving pulmonary bullous degeneration in HIV-infected patients. Description of 4 cases and review of the literature].
Cavitary lung lesions are common in intravenous drug-addicts (IVDA) and in AIDS patients. Four cases are reported of IVDA patients with HIV positive serology who developed an initially thick-walled lesion, which grew rapidly and evolved into bullous lesions. The negative results in microbiological investigations for Pneumocystis carinii, Nocardia spp., staphylococci; the topographic superposition on a previous tuberculous lesion; a prolonged asymptomatic period; and a particularly rapid evolution in all cases led us to consider the rapidly evolving bullous degeneration to be more than a casual finding. Previous infection with M. tuberculosis in AIDS patients might somehow influence on the later development of a rapidly growing, fatal, bullous degenerative lesion. The elucidation of the pathogenic mechanisms of these lesions was hampered by the lack of pathological studies.
Prada Pardal
J L
JL
Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sofía, Córdoba.
Villanueva Marcos
J L
JL
Kindelán Jaquotot
J M
JM
Jurado Jiménez
R
R
Escribano Fernández
J
J
Sánchez Guijo
P
P
Torre-Cisneros
J
J
D000328:Adult; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D011859:Radiography; D015819:Substance Abuse, Intravenous / Q000150:complications; D014397:Tuberculosis, Pulmonary / Q000150:complications
Degeneración bullosa pulmonar de rápida evolución en pacientes infectados por el VIH. Descripción de cuatro casos y revisión de la literatura.