title: Antimicrobial activity of FK-037, a new broad-spectrum cephalosporin. International in vitro comparison with cefepime and ceftazidime.
abstract: The in vitro activity of FK-037, a new parenteral 7-aminothiazolyl-methoxyimino cephalosporin, was compared with cefepime and ceftazidime against 6094 aerobic isolates collected in six medical centers worldwide. FK-037 demonstrated potent activity against the Enterobacteriaceae family except for some Enterobacter spp., Providencia spp., and Serratia liquefaciens (MIC90s, > or = 16 micrograms/ml). Against nonenteric Gram-negative bacilli, all compounds tested showed similar, but more limited activity. The FK-037 MIC50s for Pseudomonas spp. and P. aeruginosa were 2 and 4 micrograms/ml, respectively. The least susceptible organisms were Xanthomonas maltophilia, enterococci, and Bacillus spp. (MIC50s, > 16 micrograms/ml), followed by Flavobacterium spp., other nonenterics, and oxacillin-resistant Staphylococcus aureus (MIC50s, 16 micrograms/ml). Good FK-037 activity was observed against oxacillin-susceptible staphylococci as well as against beta-hemolytic and viridans-group streptococci (MIC90 range, < or = 0.12 to 2 micrograms/ml). While FK-037 was slightly more active than cefepime against Gram-positive organisms, enteric bacilli were most susceptible to cefepime. Overall, the antibacterial spectrum of both FK-037 and cefepime was superior to ceftazidime.
authors.affiliation: Kantonsspital Basel, University Clinics, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Frei
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: A C
authors.initials: AC
authors.lastname: Pignatari
authors.forename: N
authors.initials: N
authors.lastname: Yamane
authors.forename: F
authors.initials: F
authors.lastname: Marco
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoban
mesh_terms: D000077723:Cefepime; D002442:Ceftazidime / Q000494:pharmacology*; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D002511:Cephalosporins; C079769:cefoselis; D000077723:Cefepime; D002442:Ceftazidime; D015296:Ceftizoxime