Differential regulation of RNA polymerases I, II, and III by the TBP-binding repressor Dr1.
RNA polymerases I, II, and III each use the TATA-binding protein (TBP). Regulators that target this shared factor may therefore provide a means to coordinate the activities of the three nuclear RNA polymerases. The repressor Dr1 binds to TBP and blocks the interaction of TBP with polymerase II- and polymerase III-specific factors. This enables Dr1 to coordinately regulate transcription by RNA polymerases II and III. Under the same conditions, Dr1 does not inhibit polymerase I transcription. By selectively repressing polymerases II and III, Dr1 may shift the physiological balance of transcriptional output in favor of polymerase I.
White
R J
RJ
Wellcome/CRC Institute, University of Cambridge, UK.
Khoo
B C
BC
Inostroza
J A
JA
Reinberg
D
D
Jackson
S P
SP
D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000378:metabolism / Q000494:pharmacology*; D012318:RNA Polymerase I / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D012320:RNA Polymerase III / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D016385:TATA Box; D035381:TATA-Binding Protein Associated Factors; D035181:TATA-Box Binding Protein; D035581:Transcription Factor TFIIB; D035361:Transcription Factor TFIIIB; D014157:Transcription Factors / Q000378:metabolism / Q000494:pharmacology*; D019474:Transcription Factors, TFIII; D014158:Transcription, Genetic / Q000187:drug effects*; D000098832:Transcription Factor TFIIIC
C090956:BRF1 protein, S cerevisiae; C441028:BRF1 protein, human; D004268:DNA-Binding Proteins; D010750:Phosphoproteins; D029701:Saccharomyces cerevisiae Proteins; D035381:TATA-Binding Protein Associated Factors; D035181:TATA-Box Binding Protein; D035581:Transcription Factor TFIIB; D035361:Transcription Factor TFIIIB; D014157:Transcription Factors; D019474:Transcription Factors, TFIII; C075995:down-regulator of transcription 1; D000098832:Transcription Factor TFIIIC; D012319:RNA Polymerase II; D012318:RNA Polymerase I; D012320:RNA Polymerase III