Clearance receptors for tissue-type plasminogen activator.
Hepatic clearance is one of the principal mechanisms regulating plasma concentrations of tissue-type plasminogen activator (t-PA). Two distinct pathways appear to be involved. Liver endothelial cells and Kupffer cells clear t-PA via the mannose receptor, whereas parenchymal cells clear t-PA via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP/alpha 2-MR). This review presents the structural determinants on the t-PA molecule that mediate clearance via these two pathways, gives an overview of the structure of the LRP/alpha 2-MR and discusses the role of plasminogen activator inhibitor type 1 (PAI-1) in the hepatic clearance of t-PA.
Camani
C
C
Department of Medicine, University Hospital CHUV, Lausanne, Switzerland.
Kruithof
E K
EK
D000595:Amino Acid Sequence; D006801:Humans; D008099:Liver / Q000378:metabolism; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000737:chemistry / Q000378:metabolism
D026503:Low Density Lipoprotein Receptor-Related Protein-1; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C067262:PLAT protein, human; D010959:Tissue Plasminogen Activator