Phototherapy, photochemotherapy, and bone marrow transplantation.
Recent preclinical and clinical investigations indicate that phototherapy and photochemotherapy may have applications that go far beyond their "traditional" roles in the treatment of skin disorders, selected solid tumors, and neonatal hyperbilirubinemia. Bone marrow transplantation is one area that may benefit substantially from these new developments. This review focuses on new applications of phototherapy and photochemotherapy that pertain to the inactivation of tumor cells in autologous bone marrow grafts, the prevention and treatment of acute and chronic graft-versus-host disease, the prevention of transfusion-induced allosensitization and graft rejection, and the inactivation of pathogenic viruses and parasites in bone marrow grafts and blood products.
Sieber
F
F
Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001769:Blood / Q000382:microbiology / Q000469:parasitology / Q000528:radiation effects; D016465:Bone Marrow Purging / Q000379:methods*; D016026:Bone Marrow Transplantation; D006084:Graft Rejection / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007114:Immunization; D017053:Infection Control / Q000379:methods; D051379:Mice; D009369:Neoplasms / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology; D010789:Phototherapy; D011744:Pyrimidinones / Q000009:adverse effects / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D065227:Transfusion Reaction
D000998:Antiviral Agents; D017319:Photosensitizing Agents; D011744:Pyrimidinones; D011838:Radiation-Sensitizing Agents; C003954:merocyanine dye