title: Intralesional corticosteroid therapy for childhood cutaneous hemangiomas.
abstract: Response to intralesional steroid therapy (triamcinolone acetonide and betamethasone acetate) was studied in 70 children of all ages with 74 cutaneous hemangiomas located in a variety of locations. One to seven injections were given without anesthesia with a mean interval of 6 weeks between the injections. Results analyzed 2 months after the last injection showed more than 75% reduction in volume in 43 (58.11%), 50% to 75% reduction in 16 (21.62%), 25% to 50% reduction in 9 (12.16%), and less than 25% reduction in 6 (8.11%) lesions. Response was not related to age, sex, or site of the lesion, but only 2 lesions (22.22%) with an initial volume of more than 20 cm3 showed more than 50% reduction. None showed regrowth within a mean follow-up period of 14 months. Transient cushingoid faces and hypopigmentation were noted in 2 patients each. We feel that intralesional steroid therapy is safe and effective for all cutaneous hemangiomas irrespective of site, sex, or age of the patient.
authors.affiliation: Department of Plastic and Reconstructive Surgery, S.K. Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
authors.forename: N A
authors.initials: NA
authors.lastname: Chowdri
authors.forename: M A
authors.initials: MA
authors.lastname: Darzi
authors.forename: Z
authors.initials: Z
authors.lastname: Fazili
authors.forename: S
authors.initials: S
authors.lastname: Iqbal
mesh_terms: D001623:Betamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D018324:Hemangioma, Capillary / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D008297:Male; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000453:epidemiology; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D001623:Betamethasone; D014222:Triamcinolone Acetonide