The expression of different annexins in the fish embryo is developmentally regulated.
The expression of annexins, a family of Ca2+/phospholipid-binding proteins, was analyzed by biochemical and immunological criteria in the fish Misgurnus fossilis (loach), which is a good model system to study embryonic events. Five different annexins (loach annexins A to E) are present as a maternal pool in the unfertilized eggs. Only annexin E is newly synthesized in the early embryo. Its synthesis, already apparent at mid-blastula, decreases in later stages when two additional annexins (F and G) appear. They are present among the newly synthesized polypeptides of mid-gastrula and later embryonic stages and are also found in loach larvae. The developmentally controlled expression of several annexins indicates a specific role of these proteins at certain embryonic stages.
Ivanenkov
V V
VV
Max Planck Institute for Biophysical Chemistry, Department of Biochemistry, Goettingen, Germany.
Weber
K
K
Gerke
V
V
D000818:Animals; D017302:Annexins / Q000032:analysis* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002457:Cell Extracts / Q000737:chemistry; D003531:Cypriniformes / Q000196:embryology* / Q000235:genetics; D004625:Embryo, Nonmammalian / Q000737:chemistry*; D018507:Gene Expression Regulation, Developmental; D008081:Liposomes / Q000378:metabolism; D008970:Molecular Weight; D009928:Organ Specificity; D010063:Ovum / Q000737:chemistry*
D017302:Annexins; D002457:Cell Extracts; D008081:Liposomes