title: Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila.
abstract: Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.
authors.affiliation: Cold Spring Harbor Laboratory, New York 11724.
authors.forename: J C
authors.initials: JC
authors.lastname: Yin
authors.forename: J S
authors.initials: JS
authors.lastname: Wallach
authors.forename: M
authors.initials: M
authors.lastname: Del Vecchio
authors.forename: E L
authors.initials: EL
authors.lastname: Wilder
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: W G
authors.initials: WG
authors.lastname: Quinn
authors.forename: T
authors.initials: T
authors.lastname: Tully
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D003214:Conditioning, Classical; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics* / Q000502:physiology; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D015870:Gene Expression; D005799:Genes, Dominant / Q000502:physiology; D017344:Genes, Insect / Q000502:physiology*; D006358:Hot Temperature; D008568:Memory / Q000502:physiology*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D012333:RNA, Messenger