Australian Dental Research Fund Trebitsch Scholarship. Immunohistological analysis of an in vivo Porphyromonas gingivalis-induced lesion in mice.
Animal models have been used to study the pathogenic ability of putative periodontopathic bacteria. Injection of mice with live Porphyromonas gingivalis extracts has been shown to induce primary lesions which develop at the site of injection within one day and secondary lesions which develop at a distant site some 3-5 days later. These lesions are primarily polymorphonuclear cell (PMN) infiltrates. Recently, extensive data have shown that PMN activity may in part be controlled by T cells. Hence the aim of this report was to use the mouse model to determine the presence of T cells and macrophages in primary lesions in order to describe a baseline to be used for comparison in future studies.
Bowman
J J
JJ
Dental School, University of Queensland.
Gemmell
E
E
Bird
P S
PS
Seymour
G J
GJ
D000818:Animals; D016866:Bacteroidaceae Infections / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D005257:Fellowships and Scholarships; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D016966:Porphyromonas gingivalis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology