title: Physiopathology of primary periodontitis associated with plaque. Microbial and host factors. A review. Part 1.
abstract: Microbial factors involved in the genesis of periodontitis include colonization, bacterial penetration of the epithelium, multiplication and invasive-destructive capacity. Colonization of the gingival sulcus is related, to a certain extent, to supragingival plaque. Bacterial multiplication is induced by nutrients in the gingival fluid, and nutrients produced by degradative and excretory microbial activity. Invasion and destruction are mediated by exotoxins, structural elements of the bacteria, enzymes, metabolites, polyclonal lymphocyte activity, fibroblastic cytotoxicity, and leukocyte chemotactic inhibition.
authors.affiliation: Department of Microbiology, School of Odontology, University of Granada.
authors.forename: J
authors.initials: J
authors.lastname: Liébana
authors.forename: A
authors.initials: A
authors.lastname: Castillo
mesh_terms: D001419:Bacteria / Q000276:immunology / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D003773:Dental Plaque / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D010518:Periodontitis / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*