title: Structure-based drug design: progress, results and challenges.
abstract: Protein structure-based drug design is rapidly gaining momentum. The new opportunities, developments and results in this field are almost unbelievable compared with the situation less than a decade ago.
authors.affiliation: Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195.
authors.forename: C L
authors.initials: CL
authors.lastname: Verlinde
authors.forename: W G
authors.initials: WG
authors.lastname: Hol
mesh_terms: D000465:Algorithms; D001665:Binding Sites; D003198:Computer Simulation; D015195:Drug Design; D004791:Enzyme Inhibitors; D008024:Ligands; D010600:Pharmacology / Q000379:methods* / Q000639:trends; D011487:Protein Conformation
chemical_list: D004791:Enzyme Inhibitors; D008024:Ligands