title: Randomised controlled trial of the use of human chorionic gonadotrophin in recurrent miscarriage associated with polycystic ovaries.
abstract: OBJECTIVE
  To determine whether the use of human chorionic gonadotrophin (hCG) would reduce the recurrent miscarriage rate in women with polycystic ovarian disease.
  
  
  METHODS
  Double-blind, prospective, randomised controlled trial.
  
  
  METHODS
  A pregnancy loss clinic in a London teaching hospital.
  
  
  METHODS
  One hundred and ninety-one women with a history of three consecutive spontaneous first trimester miscarriages and polycystic ovary syndrome.
  
  
  METHODS
  10,000 i.u. of hCG or a placebo were given when the leading follicle was > or = 21 mm, then 5000 i.u. of hCG or a placebo were given twice weekly until miscarriage or the tenth week of pregnancy.
  
  
  METHODS
  Miscarriage rate.
  
  
  RESULTS
  Women with polycystic ovaries who received hCG treatment had a lower miscarriage rate (14%) compared with women who received placebo (43%). In women with follicular phase luteinising hormone > 10 iu/l, those who received hCG therapy had a miscarriage rate of 10% compared with a rate of 44% in women who received the placebo. When clomiphene was used for ovulation induction, women treated with hCG had a miscarriage rate of 14% compared with a rate 47% in women who received the placebo. There was no significant benefit from hCG therapy in natural cycles.
  
  
  CONCLUSIONS
  The use of hCG in women with recurrent miscarriage and polycystic ovary syndrome improves the pregnancy outcome.
authors.affiliation: Department of Obstetrics and Gynaecology, St George's Hospital, London.
authors.forename: J M
authors.initials: JM
authors.lastname: Pearce
authors.forename: R I
authors.initials: RI
authors.lastname: Hamid
mesh_terms: D000026:Abortion, Habitual / Q000188:drug therapy* / Q000209:etiology; D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D002996:Clomiphene