The effect of deferoxamine on brain lipid peroxide levels and Na-K ATPase activity following experimental subarachnoid hemorrhage.
1. In the present study we have studied the effects of deferoxamine treatment on lipid peroxidation and Na-K ATPase activity after experimental induction of subarachnoid haemorrhage (SAH) in guinea pigs. 2. We assessed the extent of lipid peroxidation by measuring the level of malondialdehyde and Na-K ATPase activity in 3 different groups (sham-operated, SAH, SAH + deferoxamine). 3. There was no significant difference in lipid peroxide content between sham-operated and haemorrhagic animals, but Na-K ATPase activity decreased after SAH. 4. Deferoxamine treatment reduced the malondialdehyde content and induced the recovery of Na-K ATPase activity, exerting a brain protective role against the detrimental effects of the haemorrhage.
Bilgihan
A
A
Department of Biochemistry, Gazi University, Medical Faculty, Ankara, Turkey.
Türközkan
N
N
Aricioğlu
A
A
Aykol
S
S
Cevik
C
C
Göksel
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003676:Deferoxamine / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects*; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000378:metabolism
D008054:Lipid Peroxides; D000254:Sodium-Potassium-Exchanging ATPase; D003676:Deferoxamine