title: Artificial ultraviolet whole-body radiation does not modify serum lipoprotein, plasma fibrinogen, plasminogen or antithrombin III concentrations in post-myocardial infarction patients.
abstract: The relationship of ischaemic heart disease (IHD) to seasonal and latitude variation has prompted speculation that exposure to the ultraviolet component of solar radiation may reduce IHD risk. This hypothesis was partially tested by exposing 14 post-myocardial infarction patients to a 6 week course of artificial whole-body ultraviolet radiation (UVR). Serum lipoprotein and plasma coagulation factor concentrations were measured before and after the course of UVR. Results were compared with similar measurements from a placebo-controlled group of 13 post-myocardial patients. Despite a more than two-fold rise in mean serum 25-OHD, serum lipoprotein and plasma fibrinogen, antithrombin III and plasminogen concentrations did not change significantly in the UVR group. Significant but minor change in prothrombin time and thrombin time in the placebo group appear unlikely to be of biological significance. Seasonal and latitude variation in these IHD risk factors appear unrelated to corresponding variation in solar UVR exposure.
authors.affiliation: Department of Biochemistry, Stobhill General Hospital, Glasgow, UK.
authors.forename: P
authors.initials: P
authors.lastname: Clark
authors.forename: F
authors.initials: F
authors.lastname: Cockburn
authors.forename: R A
authors.initials: RA
authors.lastname: Cowan
authors.forename: K
authors.initials: K
authors.lastname: Czapla
authors.forename: M G
authors.initials: MG
authors.lastname: Dunnigan
authors.forename: E
authors.initials: E
authors.lastname: Farish
authors.forename: E
authors.initials: E
authors.lastname: Hughes
mesh_terms: D000990:Antithrombin III / Q000378:metabolism* / Q000528:radiation effects; D005260:Female; D005340:Fibrinogen / Q000378:metabolism* / Q000528:radiation effects; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000532:radiotherapy*; D010958:Plasminogen / Q000378:metabolism* / Q000528:radiation effects; D011517:Prothrombin Time; D013918:Thrombin Time; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy; D014916:Whole-Body Irradiation
chemical_list: D008074:Lipoproteins; D000990:Antithrombin III; D005340:Fibrinogen; D010958:Plasminogen