title: Optic pathway glioma infiltrating into somatostatinergic pathways in a young boy with gigantism. Case report.
abstract: The authors report gigantism in a 16-month-old boy with an extensive optic pathway glioma infiltrating into somatostatinergic pathways, as revealed by magnetic resonance imaging and immunocytochemical studies. Stereotactic biopsies of areas showing hyperintense signal abnormalities on T2-weighted images in and adjacent to the involved visual pathways provided rarely obtained histological correlation of such areas. The patient received chemotherapy, which resulted in reduction of size and signal intensity of the tumor and stabilization of vision and growth velocity.
authors.affiliation: Department of Neurosurgery, National Naval Medical Center, Bethesda, Maryland.
authors.forename: T J
authors.initials: TJ
authors.lastname: Manski
authors.forename: C S
authors.initials: CS
authors.lastname: Haworth
authors.forename: B J
authors.initials: BJ
authors.lastname: Duval-Arnould
authors.forename: E J
authors.initials: EJ
authors.lastname: Rushing
mesh_terms: D001254:Astrocytoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D003131:Combined Modality Therapy; D003390:Cranial Nerve Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005877:Gigantism / Q000209:etiology*; D005910:Glioma / Q000150:complications*; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D007223:Infant; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D009897:Optic Chiasm; D009901:Optic Nerve Diseases / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D017287:Ventriculoperitoneal Shunt
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone