title: Use of cultured human epidermal allografts for the treatment of extensive partial thickness scald burn in children.
abstract: In spite of recent progress in burn treatment, the early surgical therapy of partial thickness scald burns in children is still controversial. Early tangential excisions is not easily applicable for these patients because of difficulties in determination of the burn depth and probable physiological derangement after surgery. Hypertrophic scar formation and wound contraction after meshed autografts are other limitations. For these reasons, conservative treatment, not early excision therapy, has been chosen initially for these injuries. We used cultured epidermal allografts for extensive, partial thickness scald burns, during the early post-burn period without escharectomy. Fifty to 100% of the engrafted superficial dermal burns were epithelialized within 7 days. In contrast, untreated identical wounds remained open. Repeated grafting of cultured allografts on unexcised wound granulations of dermal burns also enhanced epithelialization. Long term results showed that hypertrophic scar formation in the mixed superficial and deep dermal burns was reduced when cultured allografts were used. Allografting of the cultured epidermis without surgical excision apparently promoted the rapid regeneration of the partial thickness burns. Procedural complications did not occur. Cultured allografts should be used as an effective and safe biological dressing for partial thickness scald burns in children.
authors.affiliation: Department of Surgery II, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Soeda
authors.forename: S
authors.initials: S
authors.lastname: Inokuchi
authors.forename: S
authors.initials: S
authors.lastname: Ueno
authors.forename: S
authors.initials: S
authors.lastname: Yokoyama
authors.forename: M
authors.initials: M
authors.lastname: Kidokoro
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Katoh
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: M
authors.initials: M
authors.lastname: Osada
authors.forename: T
authors.initials: T
authors.lastname: Mitomi
mesh_terms: D002056:Burns / Q000473:pathology / Q000601:surgery*; D002478:Cells, Cultured; D002648:Child; D017439:Cicatrix, Hypertrophic / Q000517:prevention & control; D004817:Epidermis / Q000473:pathology / Q000637:transplantation*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016038:Skin Transplantation / Q000379:methods* / Q000473:pathology; D014184:Transplantation, Homologous; D014945:Wound Healing