title: Hepatic clearance of chylomicron remnants in mice lacking apoprotein E.
abstract: Control and apoprotein E-deficient mice generated by gene targeting in embryonic stem cells were fed a fat load containing 3H-labeled retinol and the absorbed radioactivity present in the plasma, liver, and carcass measured 6 h later. The radioactivity in the plasma of the apoprotein E-deficient mice was several fold higher than in control animals, but it accounted for less than 1/5 of the absorbed radioactivity. In both groups of animals most of the absorbed radioactivity was recovered in the livers. These findings indicate that in apoprotein E-deficient mice chylomicron remnants can be taken up by the liver by a process that does not require the mediation of apoprotein E.
authors.affiliation: Department of Pathology, Northwestern University Medical School, Chicago, IL 60611.
authors.forename: S
authors.initials: S
authors.lastname: Chang
authors.forename: S H
authors.initials: SH
authors.lastname: Zhang
authors.forename: N
authors.initials: N
authors.lastname: Maeda
authors.forename: J
authors.initials: J
authors.lastname: Borensztajn
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency*; D002914:Chylomicrons / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D014316:Tritium; D014801:Vitamin A / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D001057:Apolipoproteins E; D002914:Chylomicrons; D014316:Tritium; D014801:Vitamin A