title: Correlation of electroretinographic and fluorescein angiographic findings in unilateral central retinal vein obstruction.
abstract: BACKGROUND
  In central retinal vein obstruction (CRVO), electroretinogram (ERG) abnormalities and extensive retinal capillary dropout (CD) in the fluorescein angiogram (FA) are good indicators of retinal ischemia. We retrospectively studied patients with unilateral CRVO and compared the ERG and FA results.
  
  
  METHODS
  Single white flash ERG, photopic ERG, scotopic ERG and flicker ERG were recorded in 30 cases of unilateral CRVO. We analyzed the correlation between the ERG results and the presence/absence of extensive CD.
  
  
  RESULTS
  The ERG b/a-wave amplitude ratios, photopic and scotopic b-wave amplitudes, and flicker amplitudes were significantly smaller (P < 0.05) in eyes with extensive CD (n = 12, 40%), than in eyes without (n = 18, 60%). When the photopic or scotopic b-wave amplitudes were normal or supernormal, extensive CD on FA was absent in all eyes. When the b/a-wave ratios were > or = 1.0 or when the b-wave amplitudes with white flash or flicker amplitudes were normal or supernormal, extensive CD was present in less than 32% of eyes.
  
  
  CONCLUSIONS
  These results suggest that the ERG results, especially the b/a-wave amplitude ratio, are significantly correlated with the presence/absence of CD on FA in CRVO.
authors.affiliation: Clinical Research Unit, Schepens Eye Research Institute, Boston, Massachusetts.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsui
authors.forename: O
authors.initials: O
authors.lastname: Katsumi
authors.forename: M C
authors.initials: MC
authors.lastname: Mehta
authors.forename: T
authors.initials: T
authors.lastname: Hirose
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011379:Prognosis; D012170:Retinal Vein Occlusion / Q000503:physiopathology*; D012171:Retinal Vessels / Q000502:physiology; D012189:Retrospective Studies; D014792:Visual Acuity