title: Seasonal variation in frequency of diagnosis of cutaneous malignant melanoma.
abstract: Incident cases of in situ and invasive cutaneous malignant melanoma diagnosed during 1975-90 were identified through the National Cancer Institute's Surveillance, Epidemiology, and End Results program. We studied the 32,868 white subjects diagnosed with melanoma, who were living in nine cancer registry areas covering approximately 10% of the population of the USA. The summer-to-winter ratio, defined as the ratio of the number of melanomas diagnosed during June to August (summer), to the number of melanomas diagnosed during December to February (winter), was determined according to gender, stage, histologic type and anatomic site. Summer-to-winter ratios were 1.47 (95% confidence interval (CI) 1.37-1.58) for in situ; 1.43 (95% CI 1.38-1.48) for local stage; 1.24 (95% CI 1.12-1.38) for regional stage; and 0.95 (95% CI 0.82-1.11) for distant stage melanoma. For the melanomas staged as local at diagnosis (86% of the invasive melanomas staged), a July peak was observed. For each of the major histological types of local stage melanoma, summer-to-winter ratios were significantly elevated in men (range 1.24-1.41) and women (range 1.44-1.90). For the major anatomic sites (including the head and neck, which are exposed throughout the year) of local stage melanoma, summer-to-winter ratios were elevated for men (range 1.28-1.45) and for women (range 1.31-1.75).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, Rockville, MD 20852.
authors.forename: M M
authors.initials: MM
authors.lastname: Braun
authors.forename: M A
authors.initials: MA
authors.lastname: Tucker
authors.forename: S S
authors.initials: SS
authors.lastname: Devesa
authors.forename: R N
authors.initials: RN
authors.lastname: Hoover
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology* / Q000473:pathology; D009367:Neoplasm Staging; D012307:Risk Factors; D018426:SEER Program; D012621:Seasons; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology; D014481:United States / Q000453:epidemiology