title: Cimetidine in the treatment of interstitial cystitis.
abstract: OBJECTIVE
  To assess the effect of the H2-antagonist cimetidine in the treatment of patients with interstitial cystitis (IC) refractory to other conservative therapies.
  
  
  METHODS
  A group of 9 patients previously treated conservatively for IC without success were entered in the study. They were thoroughly investigated and treated with cimetidine at the dose of 300 mg orally twice a day for 1 month.
  
  
  RESULTS
  Six of the 9 patients (66%) experienced various degrees of symptomatic relief while on the drug. Of these, 4 (44%) have noted a complete and sustained response to the medication.
  
  
  CONCLUSIONS
  The encouraging results observed in this pilot study together with the simplicity and tolerance of the treatment makes it an alternative when other options have been exhausted. Its use as a first-line monotherapy remains speculative.
authors.affiliation: Department of Urology, Queen's University, Kingston, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Seshadri
authors.forename: L
authors.initials: L
authors.lastname: Emerson
authors.forename: A
authors.initials: A
authors.lastname: Morales
mesh_terms: D000284:Administration, Oral; D001706:Biopsy; D002908:Chronic Disease; D002927:Cimetidine / Q000627:therapeutic use*; D003556:Cystitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010865:Pilot Projects; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000473:pathology; D014563:Urodynamics
chemical_list: D002927:Cimetidine