Can renal handling of phosphate predict response to growth hormone therapy in normal variant short children by short-term treatment?
We investigated if renal handling of phosphate could predict height velocity in 28 normal variant short children (16 boys and 12 girls). Before and after human growth hormone was given for four consecutive days, the ratio of maximum tubular reabsorption rate for phosphorus to glomerular filtration rate (TmP/GFR) was calculated. Based on increments in TmP/GFR (delta TmP/GFR) with growth hormone administration, the patients were divided into two groups; children in whom the levels of delta TmP/GFR were 0.8 mg/dl GF or more (group A, n = 7) and those with levels less than 0.8 mg/dl GF (group B, n = 21). All children in group A and some in group B (n = 9) were injected with 0.5 IU/kg/week of recombinant human growth hormone for over one year. Height velocity during therapy was significantly greater in treated children in group A than in group B and was similar among treated (n = 9) and untreated (n = 12) children in group B. The present study suggests that change in renal handling of phosphate during short-term growth hormone administration can serve to select normal variant short children who will respond well to growth hormone therapy.
Tomoeda
S
S
Department of Pediatrics, Kumamoto University School of Medicine, Japan.
Nishiyama
S
S
Nakamura
T
T
Matsuda
I
I
D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects*; D002648:Child; D005260:Female; D005919:Glomerular Filtration Rate; D006130:Growth Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D011237:Predictive Value of Tests
D010758:Phosphorus; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone