Heat-shock protein 65 and activated gamma/delta T cells in injured arteries.
Because immune mechanisms are implicated in atherogenesis, we investigated the T-lymphocyte subset and factors related to its activation after acute arterial ligation (22 ligated and 13 non-ligated specimens). Ligated arteries produced heat-shock protein 65 (hsp65) and were infiltrated with activated T cells (mostly dendritic, CD3+, CD4-, CD8-, and gamma/delta T-cell-receptor bearing). The protein was found with dendritic T cells, with immunogold-labelled hsp65 beside the dendritic processes. Thus, the immune reaction after acute arterial injury may be associated with binding and recognition of in-situ hsp65 by dendritic gamma/delta T-cells.
Heng
M K
MK
Department of Medicine, UCLA San Fernando Valley Internal Medicine Program, Sepulveda VA Medical Center 91343.
Heng
M C
MC
D000368:Aged; D001158:Arteries / Q000737:chemistry / Q000276:immunology* / Q000293:injuries; D001161:Arteriosclerosis / Q000276:immunology; D006360:Heat-Shock Proteins / Q000032:analysis*; D006499:Hepatic Artery / Q000276:immunology / Q000293:injuries; D006801:Humans; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008297:Male; D008638:Mesenteric Arteries / Q000276:immunology / Q000293:injuries; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013601:T-Lymphocytes / Q000276:immunology*; D014947:Wounds and Injuries / Q000276:immunology*
D006360:Heat-Shock Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta