Gastrointestinal inflammation. Inflammatory bowel disease in knockout mice.
The development of gastrointestinal inflammation in recently generated gene-knockout mice suggests that inflammatory bowel disease in man may be caused by an inappropriate immune response to normal bacteria.
MacDonald
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Department of Paediatric Gastroenterology, Medical College of St Bartholomews Hospital, London, UK.
D000818:Animals; D000942:Antigens, Bacterial; D001419:Bacteria / Q000276:immunology; D004064:Digestive System / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D016753:Interleukin-10 / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics
D000942:Antigens, Bacterial; D007376:Interleukin-2; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016753:Interleukin-10