The regulatory switch of the muscle thin filament: Ca2+ or myosin heads?
Ca2+ and myosin heads are both involved in regulation, with Ca2+ as the allosteric trigger and the myosin head-induced Tm off-on transition as the switch. The allosteric/cooperative model is a good phenomenological description of part of the process and aspects of the original steric blocking model are involved in the molecular mechanisms.
Lehrer
S S
SS
Boston Biomedical Research Institute, MA.
D000818:Animals; D002118:Calcium / Q000032:analysis / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000737:chemistry / Q000502:physiology*; D009218:Myosins / Q000032:analysis / Q000737:chemistry / Q000502:physiology*
D009218:Myosins; D002118:Calcium