title: A multifaceted intervention for infants with failure to thrive. A prospective study.
abstract: OBJECTIVE
  To determine whether a multifaceted intervention decreased the incidence of failure to thrive (FTT) in a group of preterm infants with low birth weights and improved the 3-year intelligence, health, growth, and behavior status of the children with FTT.
  
  
  METHODS
  Three-year, prospective, randomized, clinical trial.
  
  
  METHODS
  Eight large university hospital sites throughout the United States.
  
  
  METHODS
  Nine hundred fourteen preterm infants with low birth weights who were born at the sites and met study criteria.
  
  
  METHODS
  Home visits weekly during the first year of life and biweekly thereafter until the age of 3 years to provide family support and implement two curricula; and attendance at a child development center from 12 months until 3 years of age, 5 days a week, to deliver an early childhood educational intervention.
  
  
  RESULTS
  The incidence of FTT did not differ between the treatment and control groups (20% vs 22%). Overall, children with FTT in the treatment group were not different from children with FTT in the follow-up group on any of the outcome variables. However, after controlling for other factors, treatment group membership significantly contributed to the prediction model of 36-month IQ (P = .005) for the children with FTT. In addition, children with FTT in the intervention group with higher compliance demonstrated higher 3-year IQ and better behavior scores than the children with FTT in the low-compliance group.
  
  
  CONCLUSIONS
  The intervention did not change the incidence of FTT or the 3-year outcomes in this low-birth-weight, preterm cohort. After controlling for multiple independent variables, marked effects on 3-year IQ were noted. In addition, these beneficial effects were most pronounced in families that were most complaint with the intervention.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock.
authors.forename: P H
authors.initials: PH
authors.lastname: Casey
authors.forename: K J
authors.initials: KJ
authors.lastname: Kelleher
authors.forename: R H
authors.initials: RH
authors.lastname: Bradley
authors.forename: K W
authors.initials: KW
authors.lastname: Kellogg
authors.forename: R S
authors.initials: RS
authors.lastname: Kirby
authors.forename: L
authors.initials: L
authors.lastname: Whiteside
mesh_terms: D002652:Child Behavior; D002675:Child, Preschool; D018479:Early Intervention, Educational; D005183:Failure to Thrive / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D007230:Infant, Low Birth Weight / Q000254:growth & development / Q000523:psychology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development / Q000523:psychology; D007360:Intelligence; D010349:Patient Compliance; D011446:Prospective Studies; D016896:Treatment Outcome