The WD gene for Wilson's disease links to the hepatitis of LEC rats.
LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEC rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper-transporting ATPase expressed in the liver.
Ono
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Chromosome Research Unit, Faculty of Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo.
Takada
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Yoshida
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MC
D000251:Adenosine Triphosphatases / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D003300:Copper / Q000378:metabolism; D003433:Crosses, Genetic; D017931:DNA Primers; D005260:Female; D008040:Genetic Linkage; D006520:Hepatitis, Animal / Q000235:genetics*; D006527:Hepatolenticular Degeneration / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D010641:Phenotype; D016133:Polymerase Chain Reaction; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains
D017931:DNA Primers; D003300:Copper; D000251:Adenosine Triphosphatases