title: The cerebral cortex origin of enflurane-induced generalized seizure in cats.
abstract: The role of sensorimotor cortex (anterior and posterior sigmoid gyri) as the origin of enflurane-induced generalized seizures was examined and compared to that of lidocaine-induced seizures in cats. The inhaled enflurane concentration was adjusted at 3.5% in oxygen, the maximum potency to induce generalized seizures. Repetitive electrical stimulation with supramaximum intensity at a forepaw (2 Hz, 0.5 ms, 10 V) induced generalized seizures, which ended with a sudden appearance of isoelectricity in the electroencephalogram (EEG), the so-called "postictal depression." Repetitive auditory stimuli also induced similar grand mal-type EEGs. Unilateral ablation of the sensorimotor cortex completely blocked the induction of generalized seizures by contralateral somatosensory stimuli. However, it had little effect on the induction of seizures by ipsilateral somatosensory stimuli or bilateral auditory stimuli. In contrast, bilateral ablation of the sensorimotor cortex did not have a significant effect on the lidocaine-induced seizures. These findings indicate that the involvement of the sensorimotor cortex is essential for the development of enflurane-induced but not lidocaine-induced seizures.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kurata
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: M
authors.initials: M
authors.lastname: Murakawa
authors.forename: T
authors.initials: T
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Shichino
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000503:physiopathology*; D002541:Cerebral Decortication; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D004737:Enflurane / Q000633:toxicity*; D005071:Evoked Potentials / Q000187:drug effects*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D011897:Random Allocation; D012640:Seizures / Q000139:chemically induced*
chemical_list: D004737:Enflurane