title: Relationship of panic, anticipatory anxiety, agoraphobia and global improvement in panic disorder with agoraphobia treated with alprazolam and exposure.
abstract: In a controlled trial of alprazolam and exposure in 154 patients with panic disorder with agoraphobia, relations between panic, anticipatory anxiety, and phobic avoidance were examined. The three symptoms were independent of one another at baseline and improved largely independently during treatment; only early improvement in avoidance predicted global improvement after treatment. Global improvement was more related to reduction of avoidance than a decrease in panics. Panic was not a valuable outcome measure in panic disorder with agoraphobia.
authors.affiliation: Institute of Psychiatry, Denmark Hill, London.
authors.forename: M
authors.initials: M
authors.lastname: Başoğlu
authors.forename: I M
authors.initials: IM
authors.lastname: Marks
authors.forename: C
authors.initials: C
authors.lastname: Kiliç
authors.forename: R P
authors.initials: RP
authors.lastname: Swinson
authors.forename: H
authors.initials: H
authors.lastname: Noshirvani
authors.forename: K
authors.initials: K
authors.lastname: Kuch
authors.forename: G
authors.initials: G
authors.lastname: O'Sullivan
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000523:psychology / Q000628:therapy*; D000525:Alprazolam / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000523:psychology / Q000628:therapy*; D001143:Arousal / Q000187:drug effects; D003131:Combined Modality Therapy; D003887:Desensitization, Psychologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects; D016584:Panic Disorder / Q000523:psychology / Q000628:therapy*; D010555:Personality Inventory; D016896:Treatment Outcome
chemical_list: D000525:Alprazolam