Sarcoid reactions in cystic duct carcinoma.
A diagnosis of sarcoidosis was evoked in a 61-year-old man on clinical and histologic bases. Nevertheless, a bile duct carcinoma was disclosed in association with the discovery of generalized sarcoid-like granulomas. This is only the third time that such an association has been described. HLA-B8, DR3, and DRw52 antigens were found, suggesting that altered immunologic mechanisms could play a role in the pathogenesis of this sarcoid-like reaction.
Klein
M
M
Service de Médecine J, Centre Hospitalier Universitaire de Nancy, Hôpitaux de Brabois, Vandoeuvre-lès Nancy, France.
Kaminsky
P
P
Deibener
J
J
Cocciale
M P
MP
Duc
M
M
D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000276:immunology*; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000276:immunology*; D003549:Cystic Duct; D003937:Diagnosis, Differential; D006099:Granuloma / Q000175:diagnosis* / Q000276:immunology; D015795:HLA-B8 Antigen / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D059810:HLA-DR Serological Subtypes; D015803:HLA-DR3 Antigen / Q000032:analysis; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis*
D015795:HLA-B8 Antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015803:HLA-DR3 Antigen; C051104:HLA-DR52 antigen