title: [Bone marrow transplantation for a patient with ALL from her 75-year-old mother using cryopreserved bone marrow cells].
abstract: We report a 42-year-old woman with acute lymphoblastic leukemia who received allogeneic bone marrow transplantation (BMT) in the first remission from her 75-year-old, HLA-identical, MLC-non-reactive mother. Considering the difficulty to obtain a sufficient number of bone marrow cells from such an old donor, we harvested the cells (2.31 x 10(8)/kg) on day -37 and cryopreserved them until use. BMT was performed on June 3rd, 1993 after conditioning regimen with total body irradiation, high-dose AraC and cyclophosphamide. Graft-versus-host disease (GVHD) prophylaxisis was attempted by cyclosporin A and short-term methtrexate. Her hematopoietic recovery was favorable with no signs and symptoms of GVHD as far as day 218.
authors.affiliation: Department of Hematology, National Kyushu Cancer Center Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Uike
authors.forename: Y
authors.initials: Y
authors.lastname: Suehiro
authors.forename: H
authors.initials: H
authors.lastname: Takahira
authors.forename: Y
authors.initials: Y
authors.lastname: Shimada
authors.forename: Y
authors.initials: Y
authors.lastname: Nagatoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Ikuno
authors.forename: J
authors.initials: J
authors.lastname: Okamura
authors.forename: H
authors.initials: H
authors.lastname: Tasaka
authors.forename: T
authors.initials: T
authors.lastname: Miyamura
authors.forename: H
authors.initials: H
authors.lastname: Ishikura
mesh_terms: D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D015925:Cryopreservation; D005260:Female; D006801:Humans; D009035:Mothers; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014019:Tissue Donors