[Promotion of wound healing with fibroblast growth factor in combined burn radiation injury].
Rats were subjected to 15% burn and severe radiation injury. Recombinant bFGF and simple support treatment were used to treat local wound and total body injury. The results indicated that wound healing was improved by 28.5%, and the time required for 50% area of healing was 9 days earlier in the treated group than control group 60 days after injury. Pathological observation showed that bFGF stimulated proliferation of fibroblast and collagen synthesis. It improved regeneration of capillary and formation of granulation tissue. In the early phase, bFGF enhanced reactive inflammation in the wound and phagocytosis of leucocytes in the body, and enhanced recovery of natural killing activity of spleen cells. These reactions would be beneficial to local wound healing.
Zheng
J
J
Department of Hematology, Zhujiang Hospital, First Military Medical College, Guangzhou.
Wang
S
S
Guo
L
L
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000628:therapy*; D003035:Cobalt; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D005720:Gamma Rays; D008297:Male; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000008:administration & dosage; D014945:Wound Healing / Q000187:drug effects*
D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2; D003035:Cobalt