Differential cytokine production associated with distinct phases of murine graft-versus-host reaction.
Previous studies which demonstrated that cytokines such as interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are essential for the development of graft-versus-host reaction (GvHR) did not establish whether the individual cytokines were responsible for distinct features of the disease. In this report, we show that IFN-gamma production is associated with the early proliferative phase of the disease, whereas the late, destructive phase correlates with production of TNF-alpha. These studies may assist in the development of specific immunotherapies aimed at individual aspects of immunologically mediated disease.
Garside
P
P
Department of Immunology, University of Glasgow, Western Infirmary.
Reid
S
S
Steel
M
M
Mowat
A M
AM
D000818:Animals; D006086:Graft vs Host Disease / Q000276:immunology / Q000401:mortality; D006087:Graft vs Host Reaction / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D013163:Splenomegaly / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D015431:Weight Loss
D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma