title: Structure and antimicrobial activity of diterpenes from the roots of Plectranthus hereroensis.
abstract: Two abietane-type diterpenoids have been isolated from the roots of Plectranthus hereroensis (Labiatae), one being the already known horminone [1] and the other a new substance, 7 alpha,12-dihydroxy-17(15-->16)-abeo-abieta-8,12,16-triene-11 ,14-dione [2], whose structure was established by spectroscopic means. Compounds 1 and 2 showed antimicrobial activity against Staphylococcus aureus, Vibrio cholerae, Candida albicans, and Pseudomonas aeruginosa.
authors.affiliation: Faculdade de Farmácia de Lisboa, Universidade de Lisboa, Portugal.
authors.forename: O
authors.initials: O
authors.lastname: Batista
authors.forename: A
authors.initials: A
authors.lastname: Duarte
authors.forename: J
authors.initials: J
authors.lastname: Nascimento
authors.forename: M F
authors.initials: MF
authors.lastname: Simões
authors.forename: M C
authors.initials: MC
authors.lastname: de la Torre
authors.forename: B
authors.initials: B
authors.lastname: Rodríguez
mesh_terms: D045784:Abietanes; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001681:Biological Assay; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C089566:7,12-dihydroxy-17(15-16)-abieta-8,12,16-triene-11,14-dione; D045784:Abietanes; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010616:Phenanthrenes; C045490:horminone