Immunohistochemical study of placental endothelium in physiologic and gestosis-complicated pregnancies.
In this study we examined the placentae of gestosic patients and controls, with immunoistochemical method and HLA-DR monoclonal antibody, in order to show the role of placental endothelium in gestosic pathology onset. Our results show a marked expression of class II histocompatibility antigens in gestosic placentae with respect to controls. We suppose, in gestosic patients, a role for a particular, genetically determined HLA haplotype which increases disease receptivity.
de Luca Brunori
I
I
Department of Obstetrics and Gynecology, University of Pisa, Italy.
Amato
A
A
Arcidiacono
G
G
Battini
L
L
Giusti
G
G
Scida
P
P
Simonelli
M
M
Urbano
M
M
Filippeschi
M
M
D004727:Endothelium / Q000276:immunology* / Q000473:pathology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000276:immunology* / Q000473:pathology; D011225:Pre-Eclampsia / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy
D006684:HLA-DR Antigens