title: [Evaluation of changes in IL-6 in gynecological infections].
abstract: We administered imipenem/cilastatin sodium (IPM/CS) to patients with gynecological infections as initial treatment and evaluated changes in blood interleukin 6 (IL-6) as an infection marker. 1. The subjects consisted of 7 patients with chorioamnionitis, 4 with intrauterine infections, and 1 with subcutaneous abscess. IPM/CS (1-2 g/day) was intravenously drip infused. This therapy was markedly effective in 1 patient and effective in 11; the response rate was 100%. 2. IL-6 generally began to decrease earlier than CRP. Before drug administration, correlations were observed between IL-6 and CRP (r = 0.946) between IL-6 and elastase (r = 0.355), and between elastase and CRP (r = 0.579). During the entire course, correlations were observed between IL-6 and CRP (r = 0.581), between IL-6 and elastase (r = 0.303), and between elastase and CRP (r = 0.776). These results suggest that blood IL-6 reflects early the pathologic state and treatment effects, and is a useful infection marker in gynecological infections.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Yamagata University.
authors.forename: T
authors.initials: T
authors.lastname: Chimura
authors.forename: N
authors.initials: N
authors.lastname: Saitou
authors.forename: Y
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: M
authors.initials: M
authors.lastname: Matsuo
authors.forename: M
authors.initials: M
authors.lastname: Numazaki
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000097:blood* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002821:Chorioamnionitis / Q000097:blood / Q000188:drug therapy; D015377:Cilastatin / Q000627:therapeutic use; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D005831:Genital Diseases, Female / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D004338:Drug Combinations; D015850:Interleukin-6; D015377:Cilastatin; D015378:Imipenem; D002097:C-Reactive Protein; D000077728:Cilastatin, Imipenem Drug Combination; D010196:Pancreatic Elastase