title: Cognitive functioning in a mildly to moderately depressed geriatric sample: relationship to chronological age.
abstract: The neuropsychological performance of three age cohorts of depressed patients (46-59, 60-69, and 70-85) was compared with the performance of age-matched control subjects to determine whether advancing age potentiates the effect of depression on cognition. Depression and increasing age did not interact to produce more pronounced cognitive deterioration in our unmedicated, medically healthy, well-educated outpatients diagnosed with mild to moderate major depression. Test findings suggest that presence of mild to moderate depression may result in premature "aging" of specific cognitive abilities (such as nonverbal memory, word generation, and categorization), but once the seventh decade is reached, cognition in depressed and nondepressed individuals appears to be comparable.
authors.affiliation: Department of Psychiatry, Harbor-UCLA Medical Center, Torrance 90509-2910.
authors.forename: K B
authors.initials: KB
authors.lastname: Boone
authors.forename: I
authors.initials: I
authors.lastname: Lesser
authors.forename: B
authors.initials: B
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Wohl
authors.forename: N
authors.initials: N
authors.lastname: Berman
authors.forename: A
authors.initials: A
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: Palmer
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D015331:Cohort Studies; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009483:Neuropsychological Tests