title: Ki-1 large cell anaplastic lymphoma--a clinicopathological study.
abstract: Ki-1 large cell anaplastic lymphoma is a recently described variant of malignant lymphoma. A retrospective study of 10 cases of Ki-1 lymphoma was carried out at the Armed Forces Institute of Pathology (AFIP) Rawalpindi to document its clinical and morphological features. The morphological features were evaluated by a study of paraffin embedded sections stained with haematoxylin and eosin stains. Immunohistochemical stains for BER-H2 and leucocyte common antigen (LCA) were performed in all cases. The age of the patients ranged from 2 to 60 years and male to female ratio was 2.3:1. Cervical lymphadenopathy was the most common presentation. Histologically, there was a complete effacement of the lymph node architecture in 8 cases. The Reed-Sternberg like cells were seen in 2 and histiocyte like cells in 7 cases. Immunohistochemically all cases were positive for BER-H2. It is suggested that the possibility of Ki-1 lymphoma should be considered in all cases of lymphoma with pleomorphic morphology.
authors.affiliation: Armed Forces Institute of Pathology, Rawalpindi.
authors.forename: S
authors.initials: S
authors.lastname: Mushtaq
authors.forename: I A
authors.initials: IA
authors.lastname: Malik
authors.forename: M
authors.initials: M
authors.lastname: Ahmed
authors.forename: M S
authors.initials: MS
authors.lastname: Khan
authors.forename: A H
authors.initials: AH
authors.lastname: Khan
authors.forename: S
authors.initials: S
authors.lastname: Jamal
authors.forename: F A
authors.initials: FA
authors.lastname: Malik
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies