Chemotherapy of experimental filariasis: enhancement of activity profile of ivermectin with immunomodulators.
The effect of certain immunopotentiators (Freund's complete adjuvant, picroliv, tuftsin and CDRI Compound 86/448) was evaluated on exertion of antifilarial activity of ivermectin at different dose levels in cotton rats experimentally infected with Litomosoides carinii. Ivermectin alone (up to 250 micrograms/kg p.o. x 5 days) caused sterilization of most of the surviving female parasites, but had no lethal effect on adult worms. In combination with immunomodulators, ivermectin brought about significant lethal effect on adult parasites even at a dose of 1 microgram/kg x 5 days. Nevertheless, in animals receiving FCA alone, sterility was caused in > 50% of female parasites. Other immunomodulators used alone had a suppressive effect on microfilaraemia only. Immunomodulators alone or in combination with ivermectin also caused enhanced filaria-specific antibody response.
Fatma
N
N
Division of Parasitology, Central Drug Research Institute, Lucknow, India.
Mathur
K B
KB
Chatterjee
R K
RK
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000284:Administration, Oral; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D004353:Drug Evaluation, Preclinical; D005260:Female; D005368:Filariasis / Q000188:drug therapy* / Q000276:immunology; D005370:Filarioidea / Q000187:drug effects / Q000302:isolation & purification; D007559:Ivermectin / Q000627:therapeutic use*; D051381:Rats
D000276:Adjuvants, Immunologic; D000909:Antibodies, Helminth; D007559:Ivermectin