title: Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
abstract: The cytostatic potency of PMEA was evaluated on five rat and mouse experimental tumors. The compound significantly inhibits three spontaneously arisen (LW13K2, A870N and LLC) tumors. Two chemically induced tumors (FBN, HEP-LEW) were not influenced by PMEA.
authors.affiliation: Department of Biology, First Faculty of Medicine, Charles University, Praha.
authors.forename: B
authors.initials: B
authors.lastname: Otová
authors.forename: D
authors.initials: D
authors.lastname: Krenová
authors.forename: Z
authors.initials: Z
authors.lastname: Zídek
authors.forename: A
authors.initials: A
authors.lastname: Holý
authors.forename: I
authors.initials: I
authors.lastname: Votruba
authors.forename: V
authors.initials: V
authors.lastname: Kren
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D063065:Organophosphonates; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine