title: Etiology of neutrophilic granulocytic hypoplasia in a case of large granular lymphocytic leukemia with paraproteinemia.
abstract: The association between large granular lymphocytic leukemia (LGLL) and neutropenia is poorly understood. We attempted to assess whether neutropenia in LGLL with paraproteinemia has a different etiology than LGLL without paraproteinemia. We found neither direct serum inhibition of granulocyte/monocyte-colony forming units in vitro nor increased immunoglobulin binding to granulocytic neutrophils, neutrophil precursors, or granulocyte/monocyte-colony stimulating factor. Clonogenic assay experiments suggested that suppression of the patient's granulocyte/monocyte-colony forming units by the neoplastic T-cells and decreased granulocyte/monocyte-colony stimulating factor production contributed to the pathogenesis of neutropenia in this particular case.
authors.affiliation: Department of Pathology and Laboratory Medicine, Department of Veterans Affairs Medical Center, Syracuse, NY 13210.
authors.forename: H D
authors.initials: HD
authors.lastname: Friedman
authors.forename: J
authors.initials: J
authors.lastname: Goldberg
authors.forename: A S
authors.initials: AS
authors.lastname: Kurec
authors.forename: F R
authors.initials: FR
authors.lastname: Davey
mesh_terms: D000368:Aged; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000150:complications*; D015458:Leukemia, T-Cell / Q000150:complications*; D008297:Male; D009503:Neutropenia / Q000209:etiology*; D009504:Neutrophils / Q000187:drug effects; D010265:Paraproteinemias / Q000150:complications*
chemical_list: D007145:Immunoglobulin kappa-Chains; D016178:Granulocyte-Macrophage Colony-Stimulating Factor