Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84.
Geninthiocin was isolated from the mycelium of Streptomyces sp. DD84 as a tipA promoter inducing substance. Based on various NMR studies, its structure was established as a thiopeptide with oxazole and thiazole moieties, and several unusual amino acids.
Yun
B S
BS
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Hidaka
T
T
Furihata
K
K
Seto
H
H
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry; D010455:Peptides; D010456:Peptides, Cyclic; D011401:Promoter Regions, Genetic; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*; D013844:Thiazoles / Q000737:chemistry; D015534:Trans-Activators
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010080:Oxazoles; D010455:Peptides; D010456:Peptides, Cyclic; D013844:Thiazoles; D015534:Trans-Activators; C089891:tipA protein, Streptomyces; C089890:geninthiocin