[Effect of oral contraceptives on the proliferative activity of breast cancer].
In 471 breast cancer patients the possible influence of an antecedent oral contraceptive (OC) use on proliferative activity (PCNA-expression) of mammary carcinomas was investigated. PCNA-expression (Proliferating Cell Nuclear Antigen) was immunohistochemically assessed using formalin-fixed, paraffin-embedded tissue. PCNA-expression discriminated tumors of low (< 20%) and increased (> or = 20%) proliferative fractions. 297 (63%) patients had ever used OCs and 202 (43%) of them were long-term users (> or = 49 months). Age adjusted proliferative fractions showed no statistically significant differences dependent on duration of OC use (never, 1-48 months, > or = 49 months), despite a slightly higher frequency of tumors with an increased PCNA-expression in ever users of OCs (p = 0.125).
Schönborn
I
I
Frauenklinik Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Freie Universität, Berlin.
Minguillon
C
C
Möhner
M
M
D000328:Adult; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects* / Q000502:physiology; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008134:Long-Term Care; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D012307:Risk Factors
D003277:Contraceptives, Oral, Combined; D018809:Proliferating Cell Nuclear Antigen
Der Einfluss oraler Kontrazeptiva auf die Proliferationsaktivität des Mammakarzinoms.