title: Cirrhosis in patients with rheumatoid arthritis receiving low dose methotrexate.
abstract: We describe three patients with RA who developed cirrhosis while taking low dose methotrexate (MTX). This report includes a review of the risk factors for cirrhosis occurring in association with MTX. Two of these patients were part of a prospective study to quantify changes in pericellular and total collagen in 76 patients with RA receiving low dose pulse MTX, giving a point prevalence of cirrhosis of 2.63%.
authors.affiliation: Department of Medicine, Repatriation General Hospital, Daw Park, South Australia.
authors.forename: G
authors.initials: G
authors.lastname: Chandran
authors.forename: M J
authors.initials: MJ
authors.lastname: Ahern
authors.forename: P D
authors.initials: PD
authors.lastname: Hall
authors.forename: R
authors.initials: R
authors.lastname: Geddes
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
authors.forename: W
authors.initials: W
authors.lastname: Hill
authors.forename: J H
authors.initials: JH
authors.lastname: Harley
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D008727:Methotrexate