[Expression of p53 in prostatic carcinoma].
The expression of the p53 protein was studied in 10 men with prostate cancer by means of an immunohistochemical method. Strong staining for p53 was found in six of ten prostate cancer (60%, mean: 26% of malignant cells stained in the positive tumours). On the other hand, the cell nuclei in benign glands did not stain positively. Immunohistochemical pattern of p53 was not related significantly to clinicopathologic parameters in the cases examined. However, significant relationship was observed between prostate cancer stage D and stage B and mean of expression of p53 in both groups. Also, relationship between mean of expression of p53 of tumoral cells of grade IV and mean of expression of p53 of tumoral cells of grades I, II and III was observed.
Valerdiz Casasola
S
S
Servicio de Anatomía Patológica, Hospital Camino de Santiago, Ponferrada, León, España.
Menéndez Colunga
M J
MJ
Martín Castillo
J
J
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53
Expresión de p53 en carcinomas de próstata.