The revised monoamine hypothesis: mechanism of antidepressant treatment in the context of behavior.
The temporal restoration of brain monoamines in the synaptic cleft due to MAO inhibition or by blocking catecholamine reuptake is only the first step on the way to recovery from depression. The second and crucial step represents the feedback system, which can provide the continuous restoration of brain monoamines in the context of free search behavior. This feedback system on the one hand helps to overcome depression and on the other hand causes the hyposensitivity of the postsynaptic catecholamine (CA) receptors, due to the increased activity of the brain CA system. According to the search activity concept, REM sleep in the healthy subject, being a part of the same feedback system, restores brain monoamines. The mechanism of REM sleep deprivation in the treatment of depression is discussed in the context of this feedback system.
Rotenberg
V S
VS
Abarbanel Mental Health Center, Bat-Yam, Israel.
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D015306:Biogenic Monoamines / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000502:physiology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D009638:Norepinephrine / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D012892:Sleep Deprivation / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D009638:Norepinephrine