Aminoglycoside pharmacokinetics: volume of distribution in specific adult patient subgroups.
OBJECTIVE
To review the published clinical studies reporting volume of distribution for aminoglycosides in patient population subgroups. Controversies in methods used are discussed.


METHODS
National Library of Medicine Medlars, searched using MEDLINE.


METHODS
Published articles primarily relating to pharmacokinetic properties of aminoglycosides in specific adult patient subgroups published within the past 20 years were included. Pediatric studies were excluded.


METHODS
The methodology, assay technique, and results from clinical studies reporting aminoglycoside volume of distribution were evaluated.


RESULTS
Clinical studies reporting aminoglycoside volume of distribution subgroups, including the methods by which their results were derived, are tabulated.


CONCLUSIONS
The expected aminoglycoside volume of distribution can vary, depending on a patient's clinical presentation. Data presented will allow a more refined initial estimation of volumes of distribution, which may facilitate the achievement of desired aminoglycoside serum concentrations.
Dager
W E
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Pharmacokinetics Consult Service, University of California, Davis Medical Center.
D000328:Adult; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D014018:Tissue Distribution
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents