Capillary zone electrophoresis in pharmaceutical and biomedical analysis.
Capillary zone electrophoresis is a technique that is rapidly gaining popularity in the pharmaceutical industry because of the wide range of compounds applicable to the technique. These range from small biologically active molecules through to large nucleotides and proteins. This review outlines the historical development of the technique and some of the basic theory of capillary zone electrophoresis. This is followed by an explanation of some of the adaptations now being used to enable the separation of neutral molecules as well as charged species, and ways of achieving chiral selectivity.
Smith
N W
NW
Chemical Analysis Department, Glaxo Group Research Limited, Middlesex, UK.
Evans
M B
MB
D001483:Base Sequence; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D004345:Drug Industry; D004586:Electrophoresis / Q000295:instrumentation*; D007700:Kinetics; D008433:Mathematics; D008969:Molecular Sequence Data; D009995:Osmosis; D013237:Stereoisomerism