[New aspects of collagen formation].
New data are presented concerning the process of synthesis and secretion of collagen. The stages are described of its elaboration and biochemical transformations of collagen molecules occurring in the cell and the alterations leading to collagen fibres building-up in the extracellular spaces. Electronic microscopy of fibrogenesis study, carried out during an experimental research on lung fibrosis, has shown new aspects not yet described in the literature. It is demonstrated that collagen fibres could be formed by assembling the tropocollagen molecules in the fibroblast cytoplasm, before the expulsion from the cell. This phenomenon could represent a new way not yet mentioned among the mechanisms of collagen synthesis. It is likely that this process take place in the framework of pathological process of fibrosis development.
Galbenu
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Institutul de pneumoftiziologie Marius Nasta, Bucureşti.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis* / Q000378:metabolism / Q000648:ultrastructure; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D008854:Microscopy, Electron; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology
D003094:Collagen
Noi aspecte privind formarea colagenului.