title: 6-Allyl-5,6-dihydro-5-hydroxypyran-2-one, a lactone produced by a new Drechslera species: specified 1H and 13C NMR assignments, mutagenic and immunomodulating testings.
abstract: A lactone (6-allyl-5,6-dihydro-5-hydroxypyran-2-one) was isolated from a new Drechslera sp. 1H and 13C NMR assignments, not previously specified, are published. No mutagenic activity on Ames/Salmonella test (strains TA98 and TA100 has been observed. Results on the respiratory metabolism of J774.1 murine macrophage indicate that the lactone might exhibit immunomodulating activity as a function of time of cellular contact and of concentration.
authors.affiliation: Groupe pour l'Etude du Devenir des Xénobiotiques dans l'Environnement (GEDEXE), UFR de Pharmacie, Meylan, France.
authors.forename: S
authors.initials: S
authors.lastname: Krivobok
authors.forename: F
authors.initials: F
authors.lastname: Thomasson
authors.forename: F
authors.initials: F
authors.lastname: Seigle-Murandi
authors.forename: R
authors.initials: R
authors.lastname: Steiman
authors.forename: C
authors.initials: C
authors.lastname: Bottex-Gauthier
mesh_terms: D000276:Adjuvants, Immunologic / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D003904:Mitosporic Fungi / Q000737:chemistry*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification* / Q000494:pharmacology; D011753:Pyrones / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: C087367:6-allyl-5,6-dihydro-5-hydroxypyran-2-one; D000276:Adjuvants, Immunologic; D009153:Mutagens; D011753:Pyrones; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue