The power of interval mapping of quantitative trait loci, using selected sib pairs.
The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.
Cardon
L R
LR
Department of Mathematics, Stanford University, CA 94305.
Fulker
D W
DW
D000465:Algorithms; D000483:Alleles; D005787:Gene Frequency; D005808:Genes, Recessive; D006580:Genetic Carrier Screening; D005826:Genetics, Medical / Q000379:methods*; D005838:Genotype; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic