title: [Pathogenetic rationale and diagnostic methods in allergic tuberculous synovitis of the knee joint].
abstract: The pathogenesis of tuberculous allergic synovitis was specified in the experiments on 44 rabbits by applying original simulation methods, including bivalent sensibilization, parallel study of the synovial fluid and serum of laboratory animals. A role of the synovial layer as an organ of immunogenesis and its impact on antibody titers were defined. A new diagnostic test, involving a diagnostic parameter and an equation for its calculation was developed. An algorithm was proposed for examining patients with synovitis (arthritis) of unknown etiology, which includes a set of significant clinical and laboratory parameters. Its testing in 64 patients enabled the tuberculous nature of the disease to be identified in 30% of cases.
authors.forename: E N
authors.initials: EN
authors.lastname: Bellendir
authors.forename: R I
authors.initials: RI
authors.lastname: Shenderova
authors.forename: V I
authors.initials: VI
authors.lastname: Goriashina
authors.forename: O A
authors.initials: OA
authors.lastname: Iakunova
authors.forename: G D
authors.initials: GD
authors.lastname: Nakonechnyĭ
mesh_terms: D000465:Algorithms; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology*; D007159:Immunologic Tests / Q000379:methods; D007719:Knee Joint; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011817:Rabbits; D013582:Synovial Fluid / Q000382:microbiology; D013585:Synovitis / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology; D014394:Tuberculosis, Osteoarticular / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial
vernacular_title: Patogeneticheskoe obosnovanie i metodika diagnostiki tuberkulezno-allergicheskogo sinovita kolennogo sustava.