title: Prostaglandin synthase. At the heart of the matter.
abstract: The structure of prostaglandin synthase, the target of aspirin therapy in cardiovascular disease, reveals a remarkable integration of the enzyme's catalytic and membrane-binding properties.
authors.forename: C
authors.initials: C
authors.lastname: Blake
mesh_terms: D001241:Aspirin / Q000494:pharmacology; D001665:Binding Sites; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000201:enzymology; D002462:Cell Membrane / Q000201:enzymology; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism
chemical_list: D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin