title: Antidepressant augmentation with lithium.
abstract: Depression is one of the most prevalent disorders seen in primary care. About 50% of depression is treated in general medical settings. Although depression is highly treatable, incomplete response to a single antidepressant is common. We describe two clinical cases in which antidepressant augmentation was a therapeutic option and lithium carbonate was an appropriate choice. A brief review of the practical aspects of the clinical pharmacology of lithium is included. Lithium is a well-tolerated, safe, and effective medication for antidepressant augmentation.
authors.affiliation: University of Tennessee/Baptist Healthplex Family Practice Residency Program, Memphis.
authors.forename: J S
authors.initials: JS
authors.lastname: Manning
authors.forename: P D
authors.initials: PD
authors.lastname: Connor
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy; D000075202:Contraindications; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male
chemical_list: D000928:Antidepressive Agents; D008094:Lithium