title: Evaluation of urinary enzymes in dogs with early renal disorder.
abstract: We investigated urinary N-acetyl-beta-D-glucosaminidase NAG (EC 3.2.1.30), gamma-glutamyl transpeptidase gamma-GTP (EC 2.3.2.2) and glycyl-prolyl dipeptidyl aminopeptidase GP-DAP (EC 3.4.14.5) in dogs with heartworm disease and renal failure. In the renal failure dogs, the NAG, gamma-GTP and GP-DAP index were significantly higher than those in the healthy dogs. In the heartworm disease dogs with normal chest X-rays (HW I), none of the enzyme values was significantly different from those of the healthy controls. In the dogs with heartworm disease showing abnormal heart shadows on their chest X-rays (HW II), enzyme values were significantly higher than those in the healthy dogs (P < 0.01) and the HW I dogs (P < 0.01). Thus, these urinary enzymes tests are available for the early detection of renal disorders.
authors.affiliation: Department of Veterinary Surgery, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uechi
authors.forename: Y
authors.initials: Y
authors.lastname: Nogami
authors.forename: H
authors.initials: H
authors.lastname: Terui
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: R
authors.initials: R
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Wakao
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000626:Aminopeptidases / Q000652:urine; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001806:Blood Urea Nitrogen; D004796:Clinical Enzyme Tests / Q000662:veterinary*; D004184:Dirofilariasis / Q000201:enzymology / Q000652:urine*; D004283:Dog Diseases; D004285:Dogs; D004798:Enzymes / Q000652:urine*; D005260:Female; D008297:Male; D013902:Radiography, Thoracic / Q000662:veterinary; D012016:Reference Values; D051437:Renal Insufficiency / Q000201:enzymology / Q000652:urine / Q000662:veterinary*; D005723:gamma-Glutamyltransferase / Q000652:urine
chemical_list: D015415:Biomarkers; D004798:Enzymes; D005723:gamma-Glutamyltransferase; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; C018085:glycylproline dipeptidyl aminopeptidase