Imprinting and anticipation. Are they relevant to genetic studies of schizophrenia?
Among 29 multiply affected pedigrees, age of onset among parents and offspring was examined for evidence of both anticipation and genomic imprinting. The results do not suggest that either mechanism is operating in schizophrenia, but only very large effects can be confidently excluded.
Asherson
P
P
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff.
Walsh
C
C
Williams
J
J
Sargeant
M
M
Taylor
C
C
Clements
A
A
Gill
M
M
Owen
M
M
McGuffin
P
P
D000328:Adult; D000367:Age Factors; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D018392:Genomic Imprinting; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010641:Phenotype; D011618:Psychotic Disorders / Q000235:genetics* / Q000523:psychology; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology