Pharmacokinetics of a single oral dose of clobazam in patients with liver disease.
The pharmacokinetic effect of a single oral in dose of 20 mg clobazam was studied in 15 patients with liver disease and in 6 healthy volunteers. Plasma concentrations of clobazam and its main metabolite, norclobazam, were measured by gas liquid chromatography. Clobazam was rapidly absorbed. Peak plasma concentrations were 350 +/- 63 ng/ml at 1.7 +/- 0.8 hr in healthy volunteers, 239 +/- 70 ng/ml at 3 +/- 1.9 hr in patients with viral hepatitis and 240 +/- 113 ng/ml at 2.5 +/- 1.5 hr in patients with cirrhosis. Total distribution volume was 173 +/- 88 l and 168 +/- 71 l in patients with viral hepatitis and cirrhosis respectively, and 81 +/- 20 l in volunteers. Corresponding half-life values were 47 +/- 18 hr and 51 +/- 21 hr in patients and 22 +/- 6.3 hr in volunteers. The difference between patients was not significant, whereas the difference between patients and volunteers was significant.
Monjanel-Mouterde
S
S
School of Pharmacy, Timone Hospital, Marseilles, France.
Antoni
M
M
Bun
H
H
Botta-Frindlund
D
D
Gauthier
A
A
Durand
A
A
Cano
J P
JP
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D000078306:Clobazam; D005260:Female; D006207:Half-Life; D006525:Hepatitis, Viral, Human / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000078306:Clobazam