title: Wallifoliol, a taxol congener with a novel carbon skeleton, from Himalayan Taxus wallichiana.
abstract: A new taxoid, wallifoliol [3], has been isolated, along with five known taxoids (taxol, cephalomannine, 10-deacetylbaccatin III, brevifoliol, 2-acetoxy brevifoliol = taxchinin A) from extracts of the needles of Himalayan Taxus wallichiana. The structure of wallifoliol has been assigned primarily from nmr studies. Wallifoliol [3] is assigned a structure in which rings A and B of the taxane system have undergone putative rearrangements producing a novel skeleton. Wallifoliol is the first diterpene to be found in nature with this particular 5/6/6/6/4 ring system.
authors.affiliation: Department of Medicinal Chemistry, University of Kansas, Lawrence 66045-2506.
authors.forename: D G
authors.initials: DG
authors.lastname: Vander Velde
authors.forename: G I
authors.initials: GI
authors.lastname: Georg
authors.forename: S R
authors.initials: SR
authors.lastname: Gollapudi
authors.forename: H B
authors.initials: HB
authors.lastname: Jampani
authors.forename: X Z
authors.initials: XZ
authors.lastname: Liang
authors.forename: L A
authors.initials: LA
authors.lastname: Mitscher
authors.forename: Q M
authors.initials: QM
authors.lastname: Ye
mesh_terms: D007194:India; D009682:Magnetic Resonance Spectroscopy; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D043823:Taxoids
chemical_list: D043823:Taxoids; C089567:wallifoliol; D017239:Paclitaxel