title: Pharmacologic intervention can reestablish baseline hemodynamic parameters during laparoscopy.
abstract: BACKGROUND
  Several studies in both animal models and human beings have shown that CO2 abdominal insufflation for laparoscopy can cause a variety of alterations in hemodynamic and pulmonary physiology. These physiologic changes could potentially have deleterious effects in patients with underlying cardiopulmonary disease.
  
  
  METHODS
  We prospectively evaluated 15 patients with preexisting heart and/or lung disease to determine whether the use of invasive monitoring would allow early identification and treatment of these physiologic alterations and thus enable laparoscopy to be performed safely in this group of patients.
  
  
  RESULTS
  CO2 abdominal insufflation caused statistically significant increases in systemic vascular resistance, mean arterial pressure, left ventricular stroke work index, and pulmonary capillary wedge pressure along with a concomitant decrease in cardiac index and oxygen delivery in these patients. The use of intravenous nitroglycerin resulted in a rapid return of the systemic vascular resistance, mean arterial pressure, pulmonary capillary wedge pressure, and cardiac index to baseline levels. No significant intraoperative or postoperative cardiac or pulmonary complications were noted.
  
  
  CONCLUSIONS
  These results suggest that laparoscopy with CO2 pneumoperitoneum can be safely performed in high-risk patients if appropriate monitoring and pharmacologic interventions are used.
authors.affiliation: Department of Surgical Oncology, UTM.D. Anderson Cancer Center, Houston 77030.
authors.forename: B W
authors.initials: BW
authors.lastname: Feig
authors.forename: D H
authors.initials: DH
authors.lastname: Berger
authors.forename: T B
authors.initials: TB
authors.lastname: Dougherty
authors.forename: J F
authors.initials: JF
authors.lastname: Dupuis
authors.forename: B
authors.initials: B
authors.lastname: Hsi
authors.forename: R C
authors.initials: RC
authors.lastname: Hickey
authors.forename: D M
authors.initials: DM
authors.lastname: Ota
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D005996:Nitroglycerin / Q000494:pharmacology; D011028:Pneumoperitoneum, Artificial; D011446:Prospective Studies
chemical_list: D005996:Nitroglycerin