19-Bromo-1-hydroxymethylbilane, a novel inhibitor of uro'gen III synthase.
A novel hydroxymethylbilane analog, 19-Br-HMB (11), has been synthesized. Its activity with the enzyme Uro'gen III synthase shows competitive inhibition.
Pichon
C
C
Department of Chemistry, Texas A & M University, College Station 77843-3255.
Atshaves
B P
BP
Danso-Danquah
R
R
Stolowich
N J
NJ
Scott
A I
AI
D001667:Binding, Competitive; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D014576:Uroporphyrinogen III Synthetase / Q000037:antagonists & inhibitors*; D014577:Uroporphyrinogens / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
C089686:19-bromo-1-hydroxymethylbilane; C089687:19-methyl-1-hydroxymethylbilane; D014577:Uroporphyrinogens; D014576:Uroporphyrinogen III Synthetase