title: [Effects and problems of intraarterial noradrenaline-induced hypertensive chemotherapy for liver metastasis of gastric cancer].
abstract: Intraarterial noradrenaline-induced hypertensive chemotherapy (NA-IHC) was performed on eight patients with liver metastasis of gastric cancer (3 synchronous and 5 metachronous). Mitomycin C was injected via the indwelling catheter placed in the proper hepatic artery, when the mean systolic blood pressure rose to 50 percent above the level in the untreated state by intravenous administration of noradrenaline. As the result, the response rate was 62.5% (CR: 1, PR: 4, NC: 2, PD: 1) and the 50% survival period was 792 days. On the other hand, another hematological metastasis developed in two cases in which liver metastases were effectively controlled. These results indicated both the effectiveness and the limits of NA-IHC as loco-regional chemotherapy. Therefore, we concluded that not only NA-IHC but also another systemic chemotherapy was necessary to treat the patient with liver metastasis of gastric cancer.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D004334:Drug Administration Schedule; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000503:physiopathology / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D009638:Norepinephrine / Q000008:administration & dosage*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D016685:Mitomycin; D009638:Norepinephrine