title: [Pathogenicity and pneumococcal capsular genes].
abstract: Pneumococci remain to be one of the most prominent human pathogens. Increasing efforts are being dedicated to the development of improved vaccines with wider specificity. Since a clear understanding of the genetics of capsular types in Streptococcus pneumoniae is missing, our efforts are oriented to characterize, at the molecular level, the genes involved in capsular polysaccharide biosynthesis. We have cloned and sequenced a chromosomal DNA fragment of a clinical isolate of type 3 pneumococcus and showed that it contains a type 3 specific gene as well as genes common to other serotypes.
authors.affiliation: Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas, CSIC, Madrid.
authors.forename: E
authors.initials: E
authors.lastname: García
authors.forename: P
authors.initials: P
authors.lastname: García
authors.forename: R
authors.initials: R
authors.lastname: López
mesh_terms: D016667:Bacterial Capsules / Q000096:biosynthesis / Q000235:genetics*; D011135:Polysaccharides, Bacterial; D013296:Streptococcus pneumoniae / Q000235:genetics* / Q000472:pathogenicity*
chemical_list: D011135:Polysaccharides, Bacterial
vernacular_title: Patogeneicidad y genes capsulares de neumococo.