title: Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).
authors.affiliation: Department of Chemistry, University of Newcastle, UK.
authors.forename: C E
authors.initials: CE
authors.lastname: Arris
authors.forename: C
authors.initials: C
authors.lastname: Bleasdale
authors.forename: A H
authors.initials: AH
authors.lastname: Calvert
authors.forename: N J
authors.initials: NJ
authors.lastname: Curtin
authors.forename: C
authors.initials: C
authors.lastname: Dalby
authors.forename: B T
authors.initials: BT
authors.lastname: Golding
authors.forename: R J
authors.initials: RJ
authors.lastname: Griffin
authors.forename: J M
authors.initials: JM
authors.lastname: Lunn
authors.forename: G N
authors.initials: GN
authors.lastname: Major
authors.forename: D R
authors.initials: DR
authors.lastname: Newell
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D015179:Colorectal Neoplasms / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008780:Methyltransferases / Q000187:drug effects* / Q000378:metabolism*; D008969:Molecular Sequence Data; D019853:O(6)-Methylguanine-DNA Methyltransferase; D013329:Structure-Activity Relationship
chemical_list: D006147:Guanine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase