Interleukin 4 receptor: signaling mechanisms.
Achsah Keegan and colleagues consider the signaling mechanisms utilized by the interleukin 4 (IL-4) receptor and review evidence suggesting that these mechanisms can account for the known responses of hematopoietic and non-hematopoietic cells to IL-4. Most of these data have been obtained from analyses of the ability of IL-4 to regulate the growth of IL-3-dependent myeloid cell lines. These results have implicated a pathway of activation homologous to that utilized by insulin and insulin-like growth factor 1 (IGF-1). However, it is possible that the regulation of growth responses through the IL-4 receptor (and other receptors), and the differentiative events elicited in lymphocytes, may not be mediated by the same post-receptor events.
Keegan
A D
AD
Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892.
Nelms
K
K
Wang
L M
LM
Pierce
J H
JH
Paul
W E
WE
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D015847:Interleukin-4 / Q000276:immunology*; D008969:Molecular Sequence Data; D018123:Receptors, Interleukin / Q000737:chemistry* / Q000276:immunology*; D019948:Receptors, Interleukin-4; D015398:Signal Transduction / Q000276:immunology*
D018123:Receptors, Interleukin; D019948:Receptors, Interleukin-4; D015847:Interleukin-4