title: Reduced fertility in females of the hereditary polydactyly rat.
abstract: The present studies assessed reproductive capacity of hereditary polydactyly(pd/pd) female rats that had genetically caused polydactyly in both fore- and hindlimbs. During an 8- or 10-day period of vaginal estrous cycle observation, persistent estrus was found in 30 to 39% of the pd/pd females. Although mating indices were comparable between polydactylous (pd/pd) and phenotypically normal (pd/+ or +/+) females, fertility indices were significantly decreased in pd/pd females. All impregnated pd/pd females delivered normally but had a significant decrease in the numbers of corpora lutea and pups delivered as compared with pd/+ or +/+ females. Examination of oviductal ova at 2 days after copulation revealed ovulation in only 75% of the pd/pd females and also a slight decrease in the numbers of ovulatory corpora lutea and oviductal ova in these females. In the nonovulating persistent estrus pd/pd females, the ovaries were polycystic. These results demonstrate a reduction in reproductive ability of pd/pd females.
authors.affiliation: Toxicology Division, Institute of Environmental Toxicology, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Teramoto
authors.forename: Y
authors.initials: Y
authors.lastname: Yamagata
authors.forename: N
authors.initials: N
authors.lastname: Hatakenaka
authors.forename: M
authors.initials: M
authors.lastname: Kaneda
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000473:pathology; D005260:Female; D007247:Infertility, Female / Q000209:etiology*; D008098:Litter Size; D010060:Ovulation; D010063:Ovum / Q000473:pathology; D017689:Polydactyly / Q000150:complications* / Q000235:genetics / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D011922:Rats, Mutant Strains