Acute cholangitis induced by carbamazepine.
We report a case of a patient with fever and intrahepatic cholestasis induced by carbamazepine (CBZ). This adverse reaction has been described in only a single case. We observed complete resolution of the hepatic damage once the agent was discontinued. CBZ rechallenge was followed by recurrence of all symptoms and abnormalities. Hepatic function improved again when CBZ was discontinued.
La Spina
I
I
Department of Neurology, City Hospital, Busto Arsizio, Varese, Italy.
Secchi
P
P
Grampa
G
G
Uccellini
D
D
Porazzi
D
D
D000208:Acute Disease; D000368:Aged; D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects*; D002761:Cholangitis / Q000139:chemically induced*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced; D004828:Epilepsies, Partial / Q000188:drug therapy; D005334:Fever / Q000139:chemically induced; D006801:Humans; D008297:Male
D002220:Carbamazepine