Heteromorphic variant 18ph+ analyzed by sequential CBG and fluorescence in situ hybridization.
An 18ph+ variant formerly detected by QFQ/CBG was subsequently analyzed by CBG and fluorescence in situ hybridization. It was found to be the consequence of amplification of alphoid DNA specific for centromeric heterochromatin of chromosome 18.
Sensi
A
A
Institute of Medical Genetics, USL 31, Ferrara, Italy.
Giunta
C
C
Bonfatti
A
A
Gruppioni
R
R
Rubini
M
M
Fontana
F
F
D002871:Chromosome Banding; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011110:Polymorphism, Genetic / Q000235:genetics