title: Immunosuppressive agents.
abstract: The present success of organ transplantation is largely due to advances in immunosuppressive therapy. Progress has been made from a cytotoxic strategy associated with a high morbidity rate to a strategy that seeks to alter the activity of cells that regulate the immune response, in order to selectively dampen antidonor responses. This article presents a comprehensive review of the clinical matrix of immunosuppressive agents, which includes various combinations of pharmacologic agents tailored to minimize toxicity and to enhance efficacy.
authors.affiliation: Department of Surgery, University of Texas Medical School at Houston.
authors.forename: B D
authors.initials: BD
authors.lastname: Kahan
authors.forename: R
authors.initials: R
authors.lastname: Ghobrial
mesh_terms: D017951:Antigen Presentation / Q000187:drug effects / Q000276:immunology; D002985:Clinical Protocols; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000145:classification / Q000276:immunology* / Q000627:therapeutic use*; D007239:Infections / Q000139:chemically induced / Q000453:epidemiology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D012307:Risk Factors; D014181:Transplantation Immunology
chemical_list: D007166:Immunosuppressive Agents