Influence of sympathetic nervous system on dexamethasone-stimulated renal tubular transport of p-aminohippurate in young rats.
After simultaneous administration of dexamethasone together with 6-hydroxydopamine or adrenergic neuronal blocking agents (alpha-methyldopa, reserpine, guanethidine) the dexamethasone-stimulated increase in renal excretion of p-aminohippurate (PAH) is distinctly diminished. The same is true for dopamine. This depressive effect could be proved by measurement of transport rates of PAH in renal cortical slices in vitro. The increase in kidney weight and in the protein content of kidney tissue in dexamethasone-treated rats is lower in rats simultaneously treated with adrenergic neuronal blocking agents of 6-hydroxydopamine. Adrenoceptor agonists and antagonists (pholedrine, orciprenaline, phentolamine, propranolol) are without influence on the dexamethasone-stimulated increase in PAH transport.
Bräunlich
H
H
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, FRG.
Rössler
S
S
Gerhardt
C
C
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003907:Dexamethasone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics*
D003907:Dexamethasone; D016627:Oxidopamine; D010130:p-Aminohippuric Acid