title: Correlation of transcranial Doppler ultrasonography with MRI and MRA in the evaluation of sickle cell disease patients with prior stroke.
abstract: We prospectively evaluated a group of patients with sickle cell disease and a clinical history of prior stroke, comparing transcranial Doppler sonography (TCD) to both magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) to determine its efficacy for the detection of flow abnormalities associated with prior cerebral infarction. Using MRI as the standard examination, there was 94% sensitivity and 30% specificity, and using MRA as the standard examination, there was 91% sensitivity and 22% specificity. We concur with other reports that the transcranial Doppler examination is a highly sensitive study. In our group of sickle cell disease patients with prior stroke, TCD reliably detected flow abnormalities that correlated to areas of prior cerebral infarction.
authors.affiliation: Department of Radiology, Tulane University Medical Center, New Orleans, LA 70112-2699.
authors.forename: M S
authors.initials: MS
authors.lastname: Kogutt
authors.forename: S S
authors.initials: SS
authors.lastname: Goldwag
authors.forename: K L
authors.initials: KL
authors.lastname: Gupta
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: J R
authors.initials: JR
authors.lastname: Humbert
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D017585:Ultrasonography, Doppler, Transcranial