title: Crocacin, a new electron transport inhibitor from Chondromyces crocatus (myxobacteria). Production, isolation, physico-chemical and biological properties.
abstract: Crocacin was isolated from the biomass of the myxobacterium Chondromyces crocatus, strain Cm c3. It inhibited the growth of a few Gram-positive bacteria and a wide spectrum of yeasts and molds. In beef heart submitochondrial particles, crocacin blocked the electron transport within the bc1-segment (complex III) and caused a red shift in the reduced spectrum of cytochrome b with a maximum at 569 nm.
authors.affiliation: GBF, Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.
authors.forename: B
authors.initials: B
authors.lastname: Kunze
authors.forename: R
authors.initials: R
authors.lastname: Jansen
authors.forename: G
authors.initials: G
authors.lastname: Höfle
authors.forename: H
authors.initials: H
authors.lastname: Reichenbach
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004579:Electron Transport / Q000187:drug effects; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009231:Myxococcales / Q000737:chemistry* / Q000378:metabolism*; D011090:Polyenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011090:Polyenes; C089608:crocacin