Hypoglycemia and hyperinsulinemia in rodent models of severe malaria infection.
Severe hypoglycemia developed during nonlethal Plasmodium chabaudi and lethal P. yoelii blood stage malaria infection in mice, always in association with hyperinsulinemia. Supernatants of lethal P. yoelii incubated overnight induced hypoglycemia and hyperinsulinemia in normal mice. In murine malaria, hypoglycemia may be largely secondary to increased insulin secretion.
Elased
K
K
Department of Immunology, University College London Medical School, United Kingdom.
Playfair
J H
JH
D000818:Animals; D006579:Heterozygote; D007003:Hypoglycemia / Q000150:complications*; D007328:Insulin / Q000097:blood*; D008288:Malaria / Q000150:complications / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010967:Plasmodium yoelii; D013997:Time Factors
D007328:Insulin