Gastric epithelial dysplasia in the natural history of gastric cancer: a multicenter prospective follow-up study. Interdisciplinary Group on Gastric Epithelial Dysplasia.
OBJECTIVE
Because the precancerous significance of gastric epithelial dysplasia (GED) is still under debate, this study attempts to ascertain whether a prospective follow-up of GED can contribute to clarifying its clinical and pathological relationships with gastric cancer (GC).


METHODS
One hundred twelve patients with mild (G1), moderate (G2), and severe (G3) GED or diagnosed as indefinite for dysplasia were prospectively followed up with a standardized endoscopic and bioptic protocol.


RESULTS
Evaluation of GED outcome refers only to 93 patients with a follow-up period longer than 12 months. Regression of dysplasia was documented in 36%, 27%, and 0% of G1, G2, and G3 GED cases, respectively. Progression to more severe dysplasia or evolution into GC was detected in 21%, 33%, and 57% of G1, G2, and G3 GED cases, respectively. Evolution into GC was documented for all grades of dysplasia and correlated significantly with high-grade atrophic gastritis. A high prevalence of early GC (86.9%) was also observed.


CONCLUSIONS
GED is a pre-invasive lesion, and carcinomatous evolution increases proportionally with its histological grade. Bioptical follow-up is mandatory for all histological grades of GED and significantly increases the likelihood of GC being detected in its early stages.
Rugge
M
M
Department of Pathology, University of Padova, Italy.
Farinati
F
F
Baffa
R
R
Sonego
F
F
Di Mario
F
F
Leandro
G
G
Valiante
F
F
D001706:Biopsy; D016009:Chi-Square Distribution; D004848:Epithelium / Q000473:pathology; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000473:pathology; D006801:Humans; D007558:Italy; D016014:Linear Models; D011230:Precancerous Conditions / Q000473:pathology*; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*