title: Cytogenetic findings in squamous cell carcinoma of the oral cavity.
abstract: A case of squamous cell carcinoma (SCC) of the oral cavity is presented which, in addition to normal metaphases, cytogenetically displayed two cell clones with chromosomal aberrations: 46,XY,1+del(5)(q13),der(18)t(5;18)(q13;p11),-5 and 49,XY,+5,+7,+10 After a review of the literature of the few cytogenetically analyzed cases, the findings confirm the multiclonal origin of oral SCC and also the commonly seen aberrations of chromosome 5.
authors.affiliation: Institute of Pathology, Medical School of the Technical University of Aachen, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Füzesi
authors.forename: S
authors.initials: S
authors.lastname: Braun
authors.forename: B
authors.initials: B
authors.lastname: Gunawan
authors.forename: H J
authors.initials: HJ
authors.lastname: Schmitz
authors.forename: C
authors.initials: C
authors.lastname: Mittermayer
mesh_terms: D000368:Aged; D002278:Carcinoma in Situ / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D003582:Cytogenetics; D006801:Humans; D008297:Male; D010157:Palatal Neoplasms / Q000235:genetics*