Protective role of sialophorin (CD43)-expressing cells in experimental Staphylococcus aureus infection.
Sialophorin (CD43) is a major surface mucin on most hematopoietic cell lineages, including phagocytes. Defects of CD43 expression occur in Wiskott-Aldrich syndrome, a disease characterized by susceptibility to pyogenic infections. In a newly established rat model of septic Staphylococcus aureus arthritis, we have investigated the role of CD43-expressing cells in the progression of the disease. A single injection of a monoclonal antibody specific for CD43 induced a highly erosive course of arthritis and increased mortality in animals exposed to a suboptimal dose of bacteria. Our results demonstrate that sialophorin-expressing cells play a protective role in the early stage of staphylococcal infection.
Bremell
T
T
Department of Clinical Immunology, University of Göteborg, Sweden.
Holmdahl
R
R
Tarkowski
A
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD; D051917:Leukosialin; D051381:Rats; D017207:Rats, Sprague-Dawley; D012795:Sialoglycoproteins / Q000502:physiology*; D013203:Staphylococcal Infections / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D051917:Leukosialin; D012795:Sialoglycoproteins; C497864:Spn protein, rat