Naturally occurring dual infection with human and bovine rotaviruses as suggested by the recovery of G1P8 and G1P5 rotaviruses from a single patient.
Culture adaptation of rotaviruses from an infant with severe diarrhea in Cincinnati, Ohio, yielded not only a virus with the original RNA electropherotype (CJN) but also rotaviruses with other electropherotypes, the most dominant of which was called CJN-M [Ward RL, Knowlton DR, Schiff GM, Hoshino Y, Greenberg HB (1988) in J Virol 62: 1543-1549]. RNA-RNA hybridization and sequencing studies indicated that CJN was a typical G1P8 human rotavirus while CJN-M was a G1P5 strain and contained four gene segments (including segment 4) of a bovine rotavirus. Thus, the infant was apparently dually infected with human and bovine rotaviruses.
Nakagomi
O
O
Department of Microbiology, Akita University School of Medicine, Japan.
Isegawa
Y
Y
Ward
R L
RL
Knowlton
D R
DR
Kaga
E
E
Nakagomi
T
T
Ueda
S
S
D000818:Animals; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D002417:Cattle / Q000821:virology; D002460:Cell Line; D002522:Chlorocebus aethiops; D003968:Diarrhea, Infantile / Q000821:virology; D004586:Electrophoresis; D006801:Humans; D007223:Infant; D008828:Microbiological Techniques; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D012401:Rotavirus / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000821:virology*; D014776:Virus Cultivation
D036022:Capsid Proteins; D012367:RNA, Viral; C060339:VP4 protein, Rotavirus