title: Stimulation of calcium sequestration by mezerein, a protein kinase C activator, in saponized rabbit platelets.
abstract: 1. The saponin-permeabilized platelet was used to examine the effect of mezerein, a moderate activator of protein kinase C (C-kinase), on the sequestration of Ca2+ to its intracellular storage sites. 2. We found that the activation of C-kinase by mezerein causes the potentiation of the Ca2+ sequestration. 3. It was suggested that C-kinase in platelets might function as a negative feedback regulator for the agonist-induced Ca2+ mobilization and might be involved in its oscillation.
authors.affiliation: Department of Pharmacology, Hiroshima University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nishio
authors.forename: Y
authors.initials: Y
authors.lastname: Ikegami
authors.forename: T
authors.initials: T
authors.lastname: Segawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nakata
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood*; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D011493:Protein Kinase C / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D012503:Saponins / Q000008:administration & dosage; D013268:Stimulation, Chemical; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D004224:Diterpenes; D012503:Saponins; D013729:Terpenes; C011309:mezerein; D011493:Protein Kinase C; D002118:Calcium