title: Maternal-fetal transport of immunoglobulin G and its subclasses during the third trimester of human pregnancy.
abstract: OBJECTIVE
  We determined the maternal-fetal transport of immunoglobulin G (IgG) during the third trimester of human pregnancy.
  
  
  METHODS
  The concentration of IgG and its subclasses (IgG1-4) was determined in sera of blood samples from 38 pregnancies collected at the time of delivery from a peripheral maternal vein (MV) and from the placental umbilical artery (UA) and vein (UV). Gestational age varied between 28 and 42 weeks (WG).
  
  
  RESULTS
  Whereas placental weight showed a significant correlation with gestational age, the maternal level of IgG and the ratio of its subclasses did not vary with gestational age. At 28-33 WG (n = 15) the mean values in the UA (5.91 +/- 1.53 g/l) and UV (6.41 +/- 1.57 g/l) for total IgG concentration were lower than in the MV (10.74 +/- 2.55 g/l). At the end of gestation (37-42 WG, n = 12), IgG in both UA (11.21 +/- 1.95 g/l) and UV (12.26 +/- 2.06 g/l) exceeded the maternal concentration (9.69 +/- 1.84 g/l). In addition to the significant positive correlation between IgG concentration in the fetal circulation (UV + UA) and gestational age (28-42 WG), an increase in the positive difference between UV and UA at the end of pregnancy indicates that there is a substantial rise in placental IgG transport capacity.
  
  
  CONCLUSIONS
  All four subclasses IgG1-4 were detectable in the umbilical circulation (28-42 WG). Whereas IgG3 and IgG4 in UA and UV had a similar concentration as in MV and remained unchanged, IgG2 increased with gestation from 0.67/0.74 g/l (UA/UV, 28-33 WG) to 1.29/1.58 g/l (UA/UV, 37-42 WG), but nevertheless remained lower than the level found in the MV (2.65 +/- 1.12 g/l). The main increase in IgG concentration, however, was due to the substantial rise in the transport of IgG1, which increased from 4.37 +/- 1.24 (UA) and 4.94 +/- 1.52 g/l (UV) at 28-33 WG to 8.94 +/- 1.66 (UA) and 10.89 +/- 1.96 g/l (UV) at the end of gestation, which was even higher than the overall IgG concentration in MV.
authors.affiliation: Department of Obstetrics and Gynecology, University of Berne, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Malek
authors.forename: R
authors.initials: R
authors.lastname: Sager
authors.forename: H
authors.initials: H
authors.lastname: Schneider
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification / Q000378:metabolism*; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014469:Umbilical Arteries / Q000276:immunology; D014471:Umbilical Veins / Q000276:immunology
chemical_list: D007074:Immunoglobulin G