Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).
Arris
C E
CE
Department of Chemistry, University of Newcastle, UK.
Bleasdale
C
C
Calvert
A H
AH
Curtin
N J
NJ
Dalby
C
C
Golding
B T
BT
Griffin
R J
RJ
Lunn
J M
JM
Major
G N
GN
Newell
D R
DR
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D015179:Colorectal Neoplasms / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008780:Methyltransferases / Q000187:drug effects* / Q000378:metabolism*; D008969:Molecular Sequence Data; D019853:O(6)-Methylguanine-DNA Methyltransferase; D013329:Structure-Activity Relationship
D006147:Guanine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase