Pathophysiology of glial growth factor receptors.
Activation and proliferation of glial cells are common events in the pathology of the nervous system. Although we are only beginning to understand the molecular signals leading to glial activation in vivo, there is increasing evidence that growth factors and their receptors may play an important part. In this paper we summarize the data on the pathophysiology of glial growth factor receptors and their ligands in the central and peripheral nervous systems.
Raivich
G
G
Department of Neuromorphology, Max-Planck Institute for Psychiatry, Martinsried, Germany.
Kreutzberg
G W
GW
D000818:Animals; D002455:Cell Division; D005314:Embryonic and Fetal Development / Q000235:genetics; D005786:Gene Expression Regulation; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000502:physiology; D008024:Ligands; D051379:Mice; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000502:physiology; D009380:Neoplasms, Nerve Tissue / Q000503:physiopathology; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009422:Nervous System Diseases / Q000503:physiopathology*; D009457:Neuroglia / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D011990:Receptors, Transferrin / Q000502:physiology; D020196:Trauma, Nervous System
D006133:Growth Substances; D008024:Ligands; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D017978:Receptors, Growth Factor; D011990:Receptors, Transferrin; D007501:Iron