title: Regulation of growth hormone secretion by the growth hormone releasing hexapeptide (GHRP-6).
abstract: Growth hormone (GH) secretion is regulated by a complex system of central and peripheral signals. Recently, a new GH-releasing hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) called GHRP-6 which specifically releases GH has been studied. In the present work the mechanism of action of GHRP-6 has been addressed in experimental animal models as well as in obese subjects. GHRP-6 releases GH independently of the hypothalamic factors GHRH and somatostatin and is a powerful GH releaser in obesity.
authors.affiliation: Institute of Endocrinology, Belgrade University, Yugoslavia.
authors.forename: D
authors.initials: D
authors.lastname: Micic
authors.forename: F
authors.initials: F
authors.lastname: Mallo
authors.forename: R
authors.initials: R
authors.lastname: Peino
authors.forename: F
authors.initials: F
authors.lastname: Cordido
authors.forename: A
authors.initials: A
authors.lastname: Leal-Cerro
authors.forename: R V
authors.initials: RV
authors.lastname: Garcia-Mayor
authors.forename: F F
authors.initials: FF
authors.lastname: Casanueva
mesh_terms: D000818:Animals; D004967:Estrogens / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D009765:Obesity / Q000503:physiopathology; D009842:Oligopeptides / Q000502:physiology*
chemical_list: D004967:Estrogens; D005938:Glucocorticoids; D009842:Oligopeptides; C041048:growth hormone releasing hexapeptide; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone