Use of glutaraldehyde solution in the treatment of acute aortic dissections.
We report on a promising method for toughening and strengthening the fragile aortic wall that involves the direct application of a 25% glutaraldehyde solution and that has proved to be both technically simple and safe. The operation was successfully employed in 5 patients with acute aortic dissections, 3 with a Stanford type A and 2 with a type B dissection. Histologic examination of the glutaraldehyde-treated portions of the aortic wall showed no detectable difference between them and the sections of untreated aortic wall. All patients survived the operation. The duration of follow-up ranged from 9 to 31 months (mean, 14.0 months). All 5 patients were in good condition at the time of the last follow-up. The preliminary results indicate that the use of a 25% glutaraldehyde solution to strengthen the aortic wall during operations for the repair of acute aortic dissections, regardless of whether they are type A or type B, may reduce the incidence of catastrophic perioperative bleeding and promote favorable results.
Chen
Y F
YF
Department of Surgery, Kaohsiung Medical College, Taiwan.
Chou
S H
SH
Chiu
C C
CC
Lin
Y T
YT
Wang
H J
HJ
D000208:Acute Disease; D000328:Adult; D000784:Aortic Dissection / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D001011:Aorta / Q000187:drug effects* / Q000473:pathology; D001014:Aortic Aneurysm / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D002648:Child; D005500:Follow-Up Studies; D005976:Glutaral / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D012996:Solutions; D015996:Survival Rate; D016896:Treatment Outcome
D012996:Solutions; D005976:Glutaral