Association of eosinophilic fasciitis, multiple morphea and antiphospholipid antibody.
The occurrence of morphea-like changes during the course of eosinophilic fasciitis is considered to be rare. We observed such a case with simultaneous occurrence of both types of lesions. Histologically, fibrosis and inflammatory infiltrate were seen in the entire dermis, the subcutis and the fascia, suggesting that the same process might account for all skin changes. In addition, our patient had an antiphospholipid antibody, neurologic symptoms and livedo-like cutaneous lesions. However, whether the antiphospholipid antibody played a pathogenic role or not remains unclear. Corticosteroid treatment was successful.
Castanet
J
J
Department of Dermatology, University of Nice, France.
Lacour
J P
JP
Perrin
C
C
Taillan
B
B
Dubois
D
D
Ortonne
J P
JP
D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D004802:Eosinophilia / Q000150:complications* / Q000276:immunology; D005208:Fasciitis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D012594:Scleroderma, Localized / Q000150:complications* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology
D017152:Antibodies, Antiphospholipid