CD8+ T-cell memory to viruses.
Recent experiments show that laboratory mice infected once with an influenza A virus or with the murine parainfluenza type 1 virus, called the Sendai virus, have enhanced numbers of cytotoxic T-lymphocyte precursors ( > 20x background) for life. Neither virus persists at the genome level, and the mice are maintained under conditions where there is no possibility of re-infection. These observations are highly relevant to any understanding of CD8+ cell memory and suggest that the clonal burst size associated with the primary challenge is a key determining factor.
Doherty
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PC
St Jude Children's Research Hospital, Memphis, Tennessee 38101-0318.
Hou
S
S
Tripp
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RA
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D007156:Immunologic Memory; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology*