title: Relationship between calcium permeability and rectification properties of AMPA receptors in cultured rat hippocampal neurons.
abstract: Cultured rat hippocampal neurons were classified into three groups on the basis of the functional properties of their AMPA-subtype glutamate receptors. The type I neuron had AMPA receptors with an outwardly rectifying I-V relation and little permeability to Ca2+ whereas the AMPA receptors in the type II neuron were characterized by marked inward rectification and high Ca2+ permeability. In the third type of neuron, the responses of AMPA receptors exhibited intermediate properties in both I-V relation and Ca2+ permeability. We suggest that these intermediate properties in the third type of neuron reflect the coexistence of Ca(2+)-permeant and Ca(2+)-impermeant AMPA receptors.
authors.affiliation: Department of Physiology, School of Medicine, Gunma University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iino
authors.forename: S
authors.initials: S
authors.lastname: Mochizuki
authors.forename: S
authors.initials: S
authors.lastname: Ozawa
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D018091:Receptors, AMPA / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
chemical_list: D018091:Receptors, AMPA; D007608:Kainic Acid; D002118:Calcium