Pharmacokinetics of single-dose administration of tinidazole in unweaned calves.
In a crossover trial, 7 healthy, 7- to 29-day-old, unweaned Finnish Ayrshire calves were given a single dose of 20 mg of tinidazole/kg of body weight, IV, and a single dose of 25 mg of tinidazole/kg orally. Blood samples were collected serially, and serum concentration of tinidazole was measured by use of high-performance liquid chromatography. Serum concentration vs time data were analyzed by use of the statistical moment theory. Terminal half-life was 394 minutes after IV administration and 524 minutes (harmonic mean) after oral administration. The corresponding system moment mean residence times were 542 +/- 61.8 minutes and 812 +/- 117 minutes (arithmetic mean +/- SD), respectively. Estimated volume of distribution at steady state and total body clearance were 0.74 +/- 0.05 L/kg and 1.37 +/- 0.13 ml/min/kg, respectively. Tinidazole was rapidly and totally absorbed from the gastrointestinal tract. Mean absorption time was 270 +/- 160 minutes, and the observed peak serum concentration was detected at 240 minutes. Bioavailability was 99.5 +/- 3.9%.
Pyörälä
S
S
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Hautjarvi, Finland.
Soback
S
S
Rainio
V
V
Silvennoinen
P
P
Nokelainen
M
M
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000097:blood / Q000378:metabolism*; D018592:Cross-Over Studies; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D014011:Tinidazole / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D014011:Tinidazole