title: Synthesis and properties of N-(aminoalkyl)-4-acetyl-3,5-dimethylpyrrole-2-carboxamides hydrochlorides.
abstract: A series of N-(aminoalkyl)-4-acetyl-3,5-dimethylpyrrole-2-carboxamides hydrochlorides have been prepared and evaluated as cytostatic agents. General procedures were developed for constructing aminoalkyl chains on the 4-acetylpyrrole-2-carboxylic acid nuclei, utilizing 2-pyridone. The results of the preliminary biological activity have been mentioned.
authors.affiliation: Department of Organic Chemistry, Medical University Białystok.
authors.forename: K
authors.initials: K
authors.lastname: Bielawski
authors.forename: J
authors.initials: J
authors.lastname: Bołtryk
authors.forename: D
authors.initials: D
authors.lastname: Bartulewicz
authors.forename: D
authors.initials: D
authors.lastname: Krajewska
authors.forename: A
authors.initials: A
authors.lastname: Rózański
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D011758:Pyrroles