title: Frequency of deletion formation decreases exponentially with distance between short direct repeats.
abstract: The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000-fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA-duplex flexibility. A similar relationship between deletion formation and distance was observed in a theta-replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.
authors.affiliation: Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, Jouy en Josas, France.
authors.forename: F
authors.initials: F
authors.lastname: Chédin
authors.forename: E
authors.initials: E
authors.lastname: Dervyn
authors.forename: R
authors.initials: R
authors.lastname: Dervyn
authors.forename: S D
authors.initials: SD
authors.lastname: Ehrlich
authors.forename: P
authors.initials: P
authors.lastname: Noirot
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics; D001483:Base Sequence; D002876:Chromosomes, Bacterial; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D017384:Sequence Deletion
chemical_list: D004269:DNA, Bacterial