title: Modeling eukaryotic transcriptional activation.
abstract: In recent years, many components involved in promoter-specific transcriptional activation in eukaryotes have been identified and characterized. We argue that a proper understanding of transcriptional activation will require quantitative modeling and we outline some of the considerations that such modeling will need to take into account.
authors.affiliation: Department of Molecular Biology, Massachusetts General Hospital, Boston.
authors.forename: R E
authors.initials: RE
authors.lastname: Kingston
authors.forename: M R
authors.initials: MR
authors.lastname: Green
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D005057:Eukaryotic Cells; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances; D008957:Models, Genetic; D008968:Molecular Conformation; D011387:Prokaryotic Cells; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D002843:Chromatin; D046911:Macromolecular Substances; D014157:Transcription Factors