Cytogenetic analysis of 11 squamous cell carcinomas of the head and neck.
We report clonal chromosomal abnormalities in short-term cultures of 11 squamous cell carcinomas of the head and neck. Recurrent deletions were seen at 1p13 (four cases), 6q15q26 (three cases), 6q21q25 (two cases), 12p11.2 (three cases), and 3p13-p23 (three cases). Structural aberrations affecting chromosome 11 with different breakpoints were seen in 7 of 11 tumors. Cytogenetic evidence for gene amplification in the form of homogeneously staining region (hsr) was seen in three tumors (two at 11q13). The results of this study shows that the 1p13, 3p13-p23, 6q15-q26, 6q21-q25, and 12p11.2 were frequently deleted in squamous cell carcinomas of the head and neck.
Rao
P H
PH
Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
Sreekantaiah
C
C
Schantz
S P
SP
Chaganti
R S
RS
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged