[The characteristics of the effect of centimeter-range microwaves on drug pharmacokinetics in the body of experimental animals].
The experiments on 130 rat males have shown that the exposure of the animals' liver to centimeter microwaves enhances catalytic activity of P-450p cytochrome, an enzyme of drug microsomal metabolism. However, changes in pharmacokinetic parameters of elimination from the blood of the drugs based on microsomal substrates of hepatic enzymatic system are more dependent on the microwaves' impact on physiological factors modifying drug pharmacokinetics. This implies the necessity of pharmacokinetic investigations in each individual case of combining drugs with microwaves.
Zolotareva
T A
TA
Grishanova
A Iu
AIu
Guliaeva
L F
LF
Liakhovich
V V
VV
Gorchakova
G A
GA
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics / Q000528:radiation effects*; D001692:Biological Transport / Q000528:radiation effects; D002384:Catalysis / Q000528:radiation effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism / Q000528:radiation effects; D006591:Hexobarbital / Q000493:pharmacokinetics / Q000528:radiation effects*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000528:radiation effects*; D008872:Microwaves; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors
D012709:Serum Albumin; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D000983:Antipyrine
Osobennosti vliianiia mikrovoln santimetrovogo diapazona na farmakokinetiku medikamentov v organizme éksperimental'nykh zhivotnykh.