Zygomycosis due to Mucor circinelloides in a neutropenic patient receiving chemotherapy for acute myelogenous leukemia.
Mucor circinelloides form circinelloides has rarely been associated with human disease, even in immunocompromised patients. We report a case of cutaneous zygomycosis caused by M. circinelloides in a 23-year-old neutropenic woman receiving consolidation chemotherapy for acute myelogenous leukemia. The organism was exquisitely susceptible to amphotericin B. Despite the fact that the patient was profoundly neutropenic for an additional 3 weeks, the lesions began to resolve during therapy, and no surgical debridement was required.
Fingeroth
J D
JD
Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
Roth
R S
RS
Talcott
J A
JA
Rinaldi
M G
MG
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D003881:Dermatomycoses / Q000188:drug therapy / Q000209:etiology; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D009089:Mucor / Q000187:drug effects / Q000302:isolation & purification*; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology*; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D009894:Opportunistic Infections / Q000188:drug therapy / Q000209:etiology
D000970:Antineoplastic Agents; D000666:Amphotericin B