An immunohistochemical study of the c-fos protooncogene in the developing human retina.
The localization and distribution of the protooncogene c-fos were studied immunohistochemically in the retina of human fetuses ranging in age from 15 to 40 weeks of gestation. The highest levels of immunoreactivity were observed in the retinae of younger fetuses, decreasing in intensity with increasing age. At 15 weeks of gestation intense immunoreactivity was observed in the inner nuclear layer while the photoreceptor cells exhibited moderate staining. At 26 weeks of gestation, immunoreactivity in the inner nuclear layer was reduced. The ganglion cells, amacrine cells and photoreceptor cells showed moderate immunopositivity throughout the 26-40 weeks period. The role of c-fos in development is discussed in the light of its other known functions.
Yu
M C
MC
Department of Anatomy, Cell Biology and Injury Sciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103.
Li
W W
WW
Liu
K
K
Yew
D T
DT
D005314:Embryonic and Fetal Development; D005333:Fetus / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D010786:Photoreceptor Cells / Q000166:cytology / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D012160:Retina / Q000196:embryology*; D012165:Retinal Ganglion Cells / Q000378:metabolism
D016760:Proto-Oncogene Proteins c-fos