title: Changes in body temperature and circulating levels of interleukin-6 after intra-arterial injections or infusions of tumor necrosis factor alpha in guinea pigs.
abstract: Tumor necrosis factor alpha (TNF) is released systematically during the early phase of endotoxin induced fever. To study the effects of this cytokine in guinea pigs, 2 micrograms TNF were intra-arterially injected as a bolus or slowly infused within 60 min. Both modes of administration induced a biphasic elevation of the animals' abdominal temperature lasting 6 h and stimulated the release of endogenous interleukin-6 (IL-6)-like activity. The second phase of the thermal response and the release of endogenous IL-6-like activity were significantly higher, when TNF was slowly infused into the animals' circulation, in spite of a transiently higher TNF-like activity after the bolus injection of TNF. Both TNF and IL-6 may therefore be regarded as candidates to trigger the febrile response in guinea pigs.
authors.affiliation: Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Giessen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Roth
authors.forename: J L
authors.initials: JL
authors.lastname: McClellan
authors.forename: M J
authors.initials: MJ
authors.lastname: Kluger
authors.forename: E
authors.initials: E
authors.lastname: Zeisberger
mesh_terms: D000818:Animals; D001831:Body Temperature; D006168:Guinea Pigs; D007261:Infusions, Intra-Arterial; D007269:Injections, Intra-Arterial; D015850:Interleukin-6 / Q000097:blood* / Q000502:physiology; D007700:Kinetics; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha