The first fatal 2,6-di-isopropylphenol (propofol) poisoning in Singapore: a case report.
The propofol levels in the blood and tissues of a 37-year-old Chinese male suspected of having fatally self-administered an intravenous dose of 1600 mg of propofol (12.3-15.4 times the dose required for the induction of anaesthesia) were determined by headspace gas chromatography. The blood (femoral), liver, kidney and brain propofol levels were 2.5 micrograms/ml, 22 micrograms/g, 3.6 micrograms/g and 11.3 micrograms/g, respectively. The blood propofol level in the present case is 11.4 times and the liver propofol level is 15.7 times that of the first propofol overdose reported in the literature.
Chao
T C
TC
Institute of Science and Forensic Medicine, National Blood Centre, Singapore.
Lo
D S
DS
Chui
P P
PP
Koh
T H
TH
D000328:Adult; D001923:Brain Chemistry; D002849:Chromatography, Gas; D017809:Fatal Outcome; D006801:Humans; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D015742:Propofol / Q000032:analysis* / Q000506:poisoning*; D013405:Suicide
D015742:Propofol