title: A comparative study between Gd-DTPA and oral magnetic particles (OMP) as gastrointestinal (GI) contrast agents for MRI of the abdomen.
abstract: In the present study we compared two gastrointestinal contrast agents--Gd-DTPA, a positive signal, and oral magnetic particles (OMP), a negative signal contrast agent--in patients who were referred for MR imaging of the abdomen. Altogether 60 patients were examined with the former and 28 patients with the latter contrast before and after the administration of contrast media. Gd-DTPA was given either per os or per rectum. In comparing the results, it was shown that the diagnostic accuracy of postcontrast MRI in both groups was more or less similar to CT but much higher as compared with plain MRI. In the OMP series, first the contrast between the GI-filled lumen and the surrounding fat was much superior to that of the Gd-DTPA and, second, there was no evidence of any artifacts from bowel motion. However, the overall accuracy of the Gd-DTPA group was better compared with that of the OMP group. This was due to underfilling of the distal bowel because the OMP in those patients was administered only per os. Finally, Gd-DTPA had a more pleasant taste and fewer side effects. It is concluded that both contrast media are suitable for the upper abdomen because the results are comparable, whereas for the lower abdomen Gd-DTPA is superior because it can be used from both routes.
authors.affiliation: Department of Radiology, Areteion University Hospital, Athens, Greece.
authors.forename: L
authors.initials: L
authors.lastname: Vlahos
authors.forename: A
authors.initials: A
authors.lastname: Gouliamos
authors.forename: A
authors.initials: A
authors.lastname: Athanasopoulou
authors.forename: G
authors.initials: G
authors.lastname: Kotoulas
authors.forename: W
authors.initials: W
authors.lastname: Claus
authors.forename: A
authors.initials: A
authors.lastname: Hatziioannou
authors.forename: A
authors.initials: A
authors.lastname: Kalovidouris
authors.forename: C
authors.initials: C
authors.lastname: Papavasiliou
mesh_terms: D000005:Abdomen / Q000473:pathology*; D000008:Abdominal Neoplasms / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects; D005260:Female; D052203:Ferrosoferric Oxide; D019786:Gadolinium DTPA; D005767:Gastrointestinal Diseases / Q000473:pathology; D006801:Humans; D007501:Iron / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000009:adverse effects; D010087:Oxides / Q000009:adverse effects; D004369:Pentetic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid; D007501:Iron; D019786:Gadolinium DTPA; D052203:Ferrosoferric Oxide