title: Automated flow-injection technique for use in dissolution studies of sustained-release formulations: application to iron(II) formulations.
abstract: The application of flow-injection analysis (FIA) to automated dissolution studies of sustained-release formulations is described. The long-term stability of the dissolution-FIA analyser was checked during unattended operation for 42 h. The construction of multiple calibration curves with the so-called electronic dilution FIA procedure was used to extend the linear range of the determination. The computer-controlled FIA system and the principles of associated software are described and applied to dissolution studies of sustained-release formulations of iron(II) using its sensitive reaction with the colour reagent, ferrozine. The extended linear range of the determination is 1-130 ppm iron(II) and the precision (RSD) better than 3% (n = 3).
authors.affiliation: Department of Chemistry, University of Athens, Panepistimiopolis, Kouponia, Greece.
authors.forename: C A
authors.initials: CA
authors.lastname: Georgiou
authors.forename: G N
authors.initials: GN
authors.lastname: Valsami
authors.forename: P E
authors.initials: PE
authors.lastname: Macheras
authors.forename: M A
authors.initials: MA
authors.lastname: Koupparis
mesh_terms: D002138:Calibration; D003692:Delayed-Action Preparations; D005296:Ferrous Compounds / Q000032:analysis / Q000378:metabolism*; D005297:Ferrozine / Q000737:chemistry; D017022:Flow Injection Analysis / Q000379:methods*; D008838:Microcomputers; D015203:Reproducibility of Results; D012995:Solubility
chemical_list: D003692:Delayed-Action Preparations; D005296:Ferrous Compounds; D005297:Ferrozine; C020748:ferrous sulfate