First trimester diagnosis of fetal nuchal edema. Report of 29 cases.
During a 4-year period, 29 fetal nuchal edemas were observed, associated with other ultrasound abnormalities in 7 cases (24%). Fetal karyotypes were abnormal in 10 cases: 6 trisomy 21; 3 trisomy 18, and 1 Turner's syndrome. Isolated fetal nuchal edema was associated with aneuploidy in 4 cases: 3 trisomy 21, and 1 trisomy 18. The average age of the women carrying a fetus with nuchal edema associated or not with a trisomy 21 was 38.3 and 30.8 years, respectively. These results are similar to those found in the literature. It would appear that maternal age is a better marker in trisomy 21 screening than isolated fetal nuchal edema.
Brun
J L
JL
Center for Prenatal Diagnosis, Maternité Pellegrin, Bordeaux, France.
Saura
R
R
Horovitz
J
J
Maugey
B
B
Taine
L
L
Roux
D
D
Vergnaud
A
A
D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D004487:Edema / Q000000981:diagnostic imaging* / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D009333:Neck; D011247:Pregnancy; D014314:Trisomy; D014424:Turner Syndrome; D016216:Ultrasonography, Prenatal