Effectiveness of cabergoline in reducing follicle-stimulating hormone and prolactin hypersecretion from pituitary macroadenoma in an infertile woman.
Dopaminergic drugs have been reported to be effective in the treatment of FSH-secreting adenomas. We describe the case of a young woman suffering from amenorrhea with radiologic signs of pituitary macroadenoma. The enlargement of both ovaries with hemorrhagic and serous cysts suggest that FSH was active biologically. The short-term (13 weeks) chronic treatment with 0.5 mg cabergoline one time per week, a dopaminergic drug with long-lasting effect, was effective in reducing FSH and PRL hypersecretion and restoring the function of the pituitary ovarian axis, as confirmed by the occurrence of pregnancy.
Paoletti
A M
AM
Istituto di Ginecologia Ostetricia e Fisiopatologia della Riproduzione Umana dell'Università degli Studi di Cagliari, Italy.
Depau
G F
GF
Mais
V
V
Guerriero
S
S
Ajossa
S
S
Melis
G B
GB
D000236:Adenoma / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D000077465:Cabergoline; D018491:Dopamine Agonists / Q000627:therapeutic use; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D011247:Pregnancy; D011388:Prolactin / Q000037:antagonists & inhibitors* / Q000378:metabolism
D018491:Dopamine Agonists; D004873:Ergolines; D011388:Prolactin; D005640:Follicle Stimulating Hormone; D000077465:Cabergoline