title: Infantile fibrosarcoma: radiological and clinical features.
abstract: Two cases of infantile fibrosarcoma are described. This rare childhood malignancy of mesodermal origin usually affects the lower limbs, as it did in both of our cases. Previously, the only treatment option available involved some form of radical and often mutilating surgery. More recently, combination chemotherapy has given good results, with the effect that various imaging modalities have become important in assessing both the initial extent of disease and the response to treatment. Computed tomography has the advantage of demonstrating the amount of osseous involvement, but at the expense of a considerable dose of ionizing radiation. On the other hand, magnetic resonance imaging, with its multiplanar capacity, gives superior demonstration of breaching of tissue planes, which has important implications for planning of surgery. However, as in other soft tissue tumours, changes in signal characteristics with treatment have proved less specific than was originally anticipated.
authors.affiliation: Department of Radiology, St. George's Hospital, London, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Vinnicombe
authors.forename: C M
authors.initials: CM
authors.lastname: Hall
mesh_terms: D001862:Bone Resorption / Q000000981:diagnostic imaging; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D005354:Fibrosarcoma / Q000151:congenital* / Q000000981:diagnostic imaging / Q000473:pathology; D005360:Fibula / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011859:Radiography; D012983:Soft Tissue Neoplasms / Q000151:congenital* / Q000000981:diagnostic imaging / Q000473:pathology; D013977:Tibia / Q000000981:diagnostic imaging