The synthesis of a water soluble complement activating polyacrylic acid-IgG polymer.
Polyacrylic acid-IgG polymer (PAA-IgG) activates the classical and alternative pathway of complement as shown by specific Clq-(IgG-PAA) interaction and the generation of C4d, Bb, C3b, C3a and C5a. This water soluble and stable PAA-IgG polymer represents a model substance for the study of humoral and cellular inflammatory mechanisms, mediated by the complement system.
Schmer
G
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Department of Laboratory Medicine, University of Washington, Seattle 98195.
Henderson
R A
RA
Müller
W
W
D000180:Acrylic Resins / Q000378:metabolism / Q000494:pharmacology*; D003167:Complement Activation / Q000187:drug effects*; D015922:Complement C1q / Q000378:metabolism; D015926:Complement C3a / Q000096:biosynthesis; D003179:Complement C3b / Q000096:biosynthesis; D003181:Complement C4 / Q000096:biosynthesis; D015935:Complement C4b; D015936:Complement C5a / Q000096:biosynthesis; D003170:Complement Pathway, Alternative / Q000187:drug effects; D003171:Complement Pathway, Classical / Q000187:drug effects; D007074:Immunoglobulin G / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000096:biosynthesis; D011108:Polymers / Q000378:metabolism / Q000494:pharmacology*; D012995:Solubility; D014867:Water
D000180:Acrylic Resins; D003181:Complement C4; D007074:Immunoglobulin G; D010446:Peptide Fragments; D011108:Polymers; C090634:polyacrylic-IgG polymer; D014867:Water; D015922:Complement C1q; D015926:Complement C3a; D003179:Complement C3b; D015935:Complement C4b; C032261:complement C4d; D015936:Complement C5a