title: Weekly low-dose methotrexate therapy for sarcoidosis.
abstract: Low-dose methotrexate therapy has been used to treat a variety of chronic inflammatory diseases; a few studies have discussed the efficacy of this therapy for sarcoidosis. We present a patient with symptomatic sarcoidosis who was successfully treated with low-dose methotrexate after being refractory to steroids. This patient showed significant clinical improvement without development of any severe side effects. These findings suggest that low-dose methotrexate therapy may be a useful alternative treatment for sarcoidosis.
authors.affiliation: Department of Internal Medicine, Hamamatsu University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Suda
authors.forename: A
authors.initials: A
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Toyoshima
authors.forename: S
authors.initials: S
authors.lastname: Imokawa
authors.forename: A
authors.initials: A
authors.lastname: Yoshitomi
authors.forename: R
authors.initials: R
authors.lastname: Tamura
authors.forename: H
authors.initials: H
authors.lastname: Suganuma
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: H
authors.initials: H
authors.lastname: Hayakawa
authors.forename: M
authors.initials: M
authors.lastname: Shirai
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000188:drug therapy*
chemical_list: D008727:Methotrexate