Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors.
Thaisrivongs
S
S
Medicinal Chemistry Research, Upjohn Laboratories, Kalamazoo, Michigan 49001.
Tomich
P K
PK
Watenpaugh
K D
KD
Chong
K T
KT
Howe
W J
WJ
Yang
C P
CP
Strohbach
J W
JW
Turner
S R
SR
McGrath
J P
JP
Bohanon
M J
MJ
D015110:4-Hydroxycoumarins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D001682:Biological Availability; D003460:Crystallization; D004285:Dogs; D015195:Drug Design; D016333:HIV Protease / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats
D015110:4-Hydroxycoumarins; D017320:HIV Protease Inhibitors; D011753:Pyrones; C089699:U 96988; D016333:HIV Protease