Topical CTC-96 accelerates wart growth in rabbits infected with cottontail rabbit papillomavirus.
CTC-96, a cobalt containing complex, was tested as a putative topical therapeutic agent for the treatment of papillomavirus-induced tumors in our cottontail rabbit papillomavirus (CRPV)-rabbit model system. Following experimental infection of domestic rabbits with CRPV, CTC-96 was applied to infection sites twice daily, 5 days a week for a total of 8 weeks. Two levels of concentrations of aqueous CTC-96 were compared to placebo control-treated animals. With increasing dose of CTC-96 we observed tumors earlier, larger, and more often across eight infected sites on each animal.
Ostrow
R S
RS
Institute of Human Genetics, Medical School, University of Minnesota, Minneapolis 55455.
Coughlin
S
S
McGlennen
R C
RC
Liu
Z
Z
Zelterman
D
D
Faras
A J
AJ
D000287:Administration, Topical; D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D012777:Cottontail rabbit papillomavirus; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D009942:Organometallic Compounds / Q000633:toxicity*; D030361:Papillomavirus Infections / Q000188:drug therapy* / Q000821:virology; D011817:Rabbits; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000821:virology; D014860:Warts / Q000188:drug therapy* / Q000473:pathology / Q000821:virology*
D000998:Antiviral Agents; D009942:Organometallic Compounds; C089809:CTC 96