Familial occurrence of LGL leukaemia.
The aetiology of LGL leukaemia is now known; however, we recently detected HTLV-II from such a patient. We describe here the occurrence of LGL leukaemia in a mother and her son. Serum from the son reacted to HTLV-I/II gag proteins, but not a recombinant HTLV-I env protein p21e; serum from the mother was negative. PCR analyses in both patients were negative for pX and pol sequences shared by HTLV-I/II and also for specific gag sequences of HTLV-I and HTLV-II. These data show that familial cases of LGL leukaemia are not associated with prototypical HTLV-I or HTLV-II infection.
Loughran
T P
TP
Veterans Administration Hospital, Syracuse, N.Y. 13210.
Kidd
P
P
Poiesz
B J
BJ
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D015139:Blotting, Southern; D005192:Family Health; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D015367:Human T-lymphotropic virus 2 / Q000302:isolation & purification; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000209:etiology* / Q000382:microbiology; D016131:Lymphocyte Subsets; D008297:Male
D015703:Antigens, CD